[ { "uniprot_canonical_ac": "Q0VCR0-1", "uniprot_ac": "Q0VCR0", "uniprot_id": "ETFR1_BOVIN", "mass": { "chemical_mass": 10705.0, "monoisotopic_mass": 10705.0 }, "refseq": { "ac": "NP_001108332", "name": "electron transfer flavoprotein regulatory factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" }, "gene_names": [ { "name": "ETFRF1", "type": "recommended", "evidence": [ { "id": "Q0VCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ] }, { "name": "ETFRF1", "type": "synonym", "evidence": [ { "id": "NP_001108332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" } ] }, { "name": "LYRM5", "type": "synonym", "evidence": [ { "id": "NP_001108332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" }, { "id": "Q0VCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ] } ], "protein_names": [ { "name": "Electron transfer flavoprotein regulatory factor 1", "type": "recommended", "evidence": [ { "id": "Q0VCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0/entry#names_and_taxonomy" } ] }, { "name": "LYR motif containing 5", "type": "synonym", "evidence": [ { "id": "NP_001108332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" } ] }, { "name": "LYR motif-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001108332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" }, { "id": "Q0VCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0/entry#names_and_taxonomy" } ] }, { "name": "electron transfer flavoprotein regulatory factor 1", "type": "synonym", "evidence": [ { "id": "NP_001108332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332" } ] } ], "function": [ { "annotation": "Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0#function" }, { "database": "UniProtKB", "id": "Q6IPR1", "url": "https://www.uniprot.org/uniprotkb/Q6IPR1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETFRF1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0", "locus": { "chromosome": "5", "start_pos": 84792354, "end_pos": 84799244, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026624", "url": "https://www.ensembl.org/id/ENSBTAG00000026624" } ] } } ], "crossref": [ { "id": "Q0VCR0", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026624", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026624", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783110", "url": "https://www.ncbi.nlm.nih.gov/gene/783110", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783110", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783110", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RAMNQRY", "url": "https://omabrowser.org/oma/group/RAMNQRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCR0", "url": "https://www.orthodb.org/?gene=Q0VCR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21024:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21024:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001108332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108332", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCR0-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANSLRGEVLNLYKNLLYLGRDYPKGADYFKRRLKNVFLKNKDVKDPEKIKELIERGKFVMKELEALYFLRKYRAMKQRYYSDTNKTK", "length": 88, "header": "sp|Q0VCR0-1|ETFR1_BOVIN Isoform 1 of Electron transfer flavoprotein regulatory factor 1 OS=Bos taurus OX=9913 GN=ETFRF1 PE=3 SV=1 CANONICAL=Q0VCR0-1" }, "isoforms": [ { "isoform_ac": "Q0VCR0-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0/entry#Q0VCR0-1", "sequence": { "sequence": "MANSLRGEVLNLYKNLLYLGRDYPKGADYFKRRLKNVFLKNKDVKDPEKIKELIERGKFVMKELEALYFLRKYRAMKQRYYSDTNKTK", "length": 88, "header": "sp|Q0VCR0-1|ETFR1_BOVIN Isoform 1 of Electron transfer flavoprotein regulatory factor 1 OS=Bos taurus OX=9913 GN=ETFRF1 PE=3 SV=1 CANONICAL=Q0VCR0-1" }, "locus": { "chromosome": "5", "start_pos": 84793383, "end_pos": 84793042, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037914.3", "url": "https://www.ensembl.org/id/ENSBTAT00000037914.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037736.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037736.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783110", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783110", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q503U1-1", "protein_name": "LYR motif-containing protein 5A", "gene_name": "lyrm5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTNPLRGEVIRLYKNLLYLGREYPKGTAYFRERLKTAFMKNKDVTDPEKIQKLIDRGDFVIKELEALYYLRKYRAMKKRYYEPEH", "length": 85 }, "evidence": [ { "id": "Q0VCR0", "url": "https://omabrowser.org/oma/group/Q0VCR0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of oxidative phosphorylation", "id": "GO:0090324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090324", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ], "pmid": "" }, { "name": "negative regulation of cellular respiration", "id": "GO:1901856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901856", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR0", "url": "https://www.uniprot.org/uniprotkb/Q0VCR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCR0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 88, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCR0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCR0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCR8-1", "uniprot_ac": "Q0VCR8", "uniprot_id": "EX3L1_BOVIN", "mass": { "chemical_mass": 81295.0, "monoisotopic_mass": 81295.0 }, "refseq": { "ac": "NP_001069350", "name": "exocyst complex component 3-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069350" }, "gene_names": [ { "name": "EXOC3L1", "type": "recommended", "evidence": [ { "id": "Q0VCR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ] }, { "name": "EXOC3L1", "type": "synonym", "evidence": [ { "id": "NP_001069350", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069350" } ] }, { "name": "EXOC3L", "type": "synonym", "evidence": [ { "id": "NP_001069350", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069350" } ] } ], "protein_names": [ { "name": "Exocyst complex component 3-like protein", "type": "recommended", "evidence": [ { "id": "Q0VCR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8/entry#names_and_taxonomy" } ] }, { "name": "exocyst complex component 3-like protein", "type": "synonym", "evidence": [ { "id": "NP_001069350", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069350" } ] } ], "function": [ { "annotation": "As part of the exocyst, may play a role in regulated exocytosis of insulin granules.", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXOC3L1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8", "locus": { "chromosome": "18", "start_pos": 34820570, "end_pos": 34826120, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012035", "url": "https://www.ensembl.org/id/ENSBTAG00000012035" } ] } } ], "crossref": [ { "id": "Q0VCR8", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCR8", "database": "AlphaFoldDB", "categories": [] }, { "id": "526306", "url": "https://www.ncbi.nlm.nih.gov/gene/526306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526306", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q0VCR8", "url": "https://www.orthodb.org/?gene=Q0VCR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069350", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCR8-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSAARDKTQPALPTGLEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRNREVQRTCSLEARIKSVVQSYLEGVKTGVWQLAQALEAVQGAREALGQARGLLRDMAEAAQTLEPLREQVVEHKQLQALSQLLPRLRAVPAAVAHTQTLIDAQRLLEAYVSLRELEQLQEETCVPLGGLELPVFEGLGPLAEALGQAVEAAAGAAGQLARENPALLVAAVRVAEVDAGCTTSLEQAPRDWRQRCLRALQQGLERVHFGTSLQPGPGELAKWLEALRVALPAELAMAEALVAPCCPPHYKVVQLWAHTLHGGLRRCLQQLLEGPELEEADTFTLLHWVLHVYQGPEMMGSLELGPEADVSDLEPLLTLENIEQLEATFVAKVQAKVAQWLQKALDGEVVEWGREQEPDTDLSGFYHSPLPAIVLQILEENIRVTRIVSVSLEQRVHGMALSELSAFLRSFTDALIRFSRDHLRGEAVVPHYVPYLLATLNHQLALSSSVSVLQPKWVVPGVLAPVEAELDKLQKRICRLVLEALLAELQPLFAALPSRRWLSSPELLDDVCKRTARFCQNFQHVRNPAVQLLLVEAERTVVLQYLSALMQGRLVCRGADERTQAAERMQHDAAQLQELFLGLGLEESVQCVPVLLALKELLNLRDPTLLGLVVAGLRQQFPDVSEDHVSALLDLRGDVSREQRLAALSSLRAGPQPSPQAGRRALFSLVPTPAPSLASCFPSGSCA", "length": 739, "header": "sp|Q0VCR8-1|EX3L1_BOVIN Isoform 1 of Exocyst complex component 3-like protein OS=Bos taurus OX=9913 GN=EXOC3L1 PE=2 SV=1 CANONICAL=Q0VCR8-1" }, "isoforms": [ { "isoform_ac": "Q0VCR8-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8/entry#Q0VCR8-1", "sequence": { "sequence": "MDSAARDKTQPALPTGLEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRNREVQRTCSLEARIKSVVQSYLEGVKTGVWQLAQALEAVQGAREALGQARGLLRDMAEAAQTLEPLREQVVEHKQLQALSQLLPRLRAVPAAVAHTQTLIDAQRLLEAYVSLRELEQLQEETCVPLGGLELPVFEGLGPLAEALGQAVEAAAGAAGQLARENPALLVAAVRVAEVDAGCTTSLEQAPRDWRQRCLRALQQGLERVHFGTSLQPGPGELAKWLEALRVALPAELAMAEALVAPCCPPHYKVVQLWAHTLHGGLRRCLQQLLEGPELEEADTFTLLHWVLHVYQGPEMMGSLELGPEADVSDLEPLLTLENIEQLEATFVAKVQAKVAQWLQKALDGEVVEWGREQEPDTDLSGFYHSPLPAIVLQILEENIRVTRIVSVSLEQRVHGMALSELSAFLRSFTDALIRFSRDHLRGEAVVPHYVPYLLATLNHQLALSSSVSVLQPKWVVPGVLAPVEAELDKLQKRICRLVLEALLAELQPLFAALPSRRWLSSPELLDDVCKRTARFCQNFQHVRNPAVQLLLVEAERTVVLQYLSALMQGRLVCRGADERTQAAERMQHDAAQLQELFLGLGLEESVQCVPVLLALKELLNLRDPTLLGLVVAGLRQQFPDVSEDHVSALLDLRGDVSREQRLAALSSLRAGPQPSPQAGRRALFSLVPTPAPSLASCFPSGSCA", "length": 739, "header": "sp|Q0VCR8-1|EX3L1_BOVIN Isoform 1 of Exocyst complex component 3-like protein OS=Bos taurus OX=9913 GN=EXOC3L1 PE=2 SV=1 CANONICAL=Q0VCR8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 724, "start_aa": "Thr", "end_pos": 724, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr724", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526306", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526306", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "exocyst localization", "id": "GO:0051601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051601", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" }, { "name": "peptide hormone secretion", "id": "GO:0030072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030072", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" }, { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "Q0VCR8", "url": "https://www.uniprot.org/uniprotkb/Q0VCR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCR8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 739, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCR8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCR8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 724 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCS4-1", "uniprot_ac": "Q0VCS4", "uniprot_id": "HXA2_BOVIN", "mass": { "chemical_mass": 40840.0, "monoisotopic_mass": 40840.0 }, "refseq": { "ac": "NP_001069322", "name": "homeobox protein Hox-A2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069322" }, "gene_names": [ { "name": "HOXA2", "type": "recommended", "evidence": [ { "id": "Q0VCS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ] }, { "name": "HOXA2", "type": "synonym", "evidence": [ { "id": "NP_001069322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069322" } ] } ], "protein_names": [ { "name": "Homeobox protein Hox-A2", "type": "recommended", "evidence": [ { "id": "Q0VCS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein Hox-A2", "type": "synonym", "evidence": [ { "id": "NP_001069322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069322" } ] } ], "function": [ { "annotation": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOXA2", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4", "locus": { "chromosome": "4", "start_pos": 68941279, "end_pos": 68939317, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008138", "url": "https://www.ensembl.org/id/ENSBTAG00000008138" } ] } } ], "crossref": [ { "id": "Q0VCS4", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524150", "url": "https://www.ncbi.nlm.nih.gov/gene/524150", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524150", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524150", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q0VCS4", "url": "https://www.orthodb.org/?gene=Q0VCS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45664", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45664", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45664:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45664:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069322", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCS4-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTVLPPASAASATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKSLEDSEKVDEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQASNGYNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGSGLNNDSPEALEVPSLQDFNVFSTDSCLQLSDAVSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY", "length": 372, "header": "sp|Q0VCS4-1|HXA2_BOVIN Isoform 1 of Homeobox protein Hox-A2 OS=Bos taurus OX=9913 GN=HOXA2 PE=2 SV=1 CANONICAL=Q0VCS4-1" }, "isoforms": [ { "isoform_ac": "Q0VCS4-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4/entry#Q0VCS4-1", "sequence": { "sequence": "MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTVLPPASAASATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKSLEDSEKVDEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQASNGYNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGSGLNNDSPEALEVPSLQDFNVFSTDSCLQLSDAVSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY", "length": 372, "header": "sp|Q0VCS4-1|HXA2_BOVIN Isoform 1 of Homeobox protein Hox-A2 OS=Bos taurus OX=9913 GN=HOXA2 PE=2 SV=1 CANONICAL=Q0VCS4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524150", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524150", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q0VCS4", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 372, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCS4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VCS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCS4" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000255", "start_pos": 139, "end_pos": 198, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCT2-1", "uniprot_ac": "Q0VCT2", "uniprot_id": "TM59L_BOVIN", "mass": { "chemical_mass": 38990.0, "monoisotopic_mass": 38990.0 }, "refseq": { "ac": "NP_001068769", "name": "transmembrane protein 59-like precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068769" }, "gene_names": [ { "name": "TMEM59L", "type": "recommended", "evidence": [ { "id": "Q0VCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2" } ] }, { "name": "TMEM59L", "type": "synonym", "evidence": [ { "id": "NP_001068769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068769" } ] } ], "protein_names": [ { "name": "Transmembrane protein 59-like", "type": "recommended", "evidence": [ { "id": "Q0VCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 59-like precursor", "type": "synonym", "evidence": [ { "id": "NP_001068769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068769" } ] } ], "function": [ { "annotation": "Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q0VCT2", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCT2", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM59L", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2", "locus": { "chromosome": "7", "start_pos": 4576426, "end_pos": 4582311, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007698", "url": "https://www.ensembl.org/id/ENSBTAG00000007698" } ] } } ], "crossref": [ { "id": "Q0VCT2", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007698", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507157", "url": "https://www.ncbi.nlm.nih.gov/gene/507157", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507157", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507157", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DNAHKVN", "url": "https://omabrowser.org/oma/group/DNAHKVN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCT2", "url": "https://www.orthodb.org/?gene=Q0VCT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28652:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28652:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068769", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCT2", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCT2-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSVALMPLLLLLLLQPPPATPAPPVRDPFALQLGDTQNCQLRCRDRYPKPQLAQEELGEDPIQSRRAKAYDRAVLTSACERGCRLFSICRFVARSSKPNATQAECEAACVEAYVKETEQQACSEGCWSQNPEPEPEPELEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDNGKVVVFQTQPVVESLGHEGARLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTSSKAKVESDELQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGYMVEPEWSLYPPPSHAYADSPPPYKLKLDLTKL", "length": 349, "header": "sp|Q0VCT2-1|TM59L_BOVIN Isoform 1 of Transmembrane protein 59-like OS=Bos taurus OX=9913 GN=TMEM59L PE=2 SV=1 CANONICAL=Q0VCT2-1" }, "isoforms": [ { "isoform_ac": "Q0VCT2-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2/entry#Q0VCT2-1", "sequence": { "sequence": "MDSVALMPLLLLLLLQPPPATPAPPVRDPFALQLGDTQNCQLRCRDRYPKPQLAQEELGEDPIQSRRAKAYDRAVLTSACERGCRLFSICRFVARSSKPNATQAECEAACVEAYVKETEQQACSEGCWSQNPEPEPEPELEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDNGKVVVFQTQPVVESLGHEGARLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTSSKAKVESDELQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGYMVEPEWSLYPPPSHAYADSPPPYKLKLDLTKL", "length": 349, "header": "sp|Q0VCT2-1|TM59L_BOVIN Isoform 1 of Transmembrane protein 59-like OS=Bos taurus OX=9913 GN=TMEM59L PE=2 SV=1 CANONICAL=Q0VCT2-1" }, "locus": { "chromosome": "7", "start_pos": 4582252, "end_pos": 4576922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010124.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010124.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010124.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010124.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 100, "start_aa": "Asn", "end_pos": 100, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn100", "evidence": [ { "id": "Q0VCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507157", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507157", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AGE2-1", "protein_name": "Transmembrane protein 59 like", "gene_name": "TMEM59L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "GLREKRETLRSVSESSDAFIGARGDRKRRLLRRTKGDLGGAEKKLKRNGCEATGPRPAALPPSRPLLRRWRFWCPSLGSRHSSAELRSLKGDLAASVPALPHVGAAGRNSDRGTKEDAVLSACYRGCRLFSICHFVDASAGLNTTRAECEAACAEAYIGEEEQWGCRTGCREQLPHVQRREQSAEVKAPSLSVLDLVSSFCTDIVSSAHSFISSTWTFYLQADDGKVVVFQSQPHMEFPLPEAQMTQPEWPGPGDDAHSPQPHAGPQQKEEKSPPGKEPWGKAKPADTPQPEHDFLGCMAKRSGLPRWILAACLFLSIVVMLWLSCASLVTAPEQHIRTQPLSINGDRECLEDPRGLSAFPLPPVIAVTLCPTHGEDVGPLPLKVDLDKTIL", "length": 392 }, "evidence": [ { "id": "Q0VCT2", "url": "https://omabrowser.org/oma/group/Q0VCT2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S907-1", "protein_name": "Transmembrane protein 59 like", "gene_name": "TMEM59L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASVVLMPLLLLLLQPPPATPAPPVRDPFALQLGDTQSCQLRCRDRYPSPQPAQELEEDPTESPHVNAYDRAVLISACERGCRLFSICRFVARSSKPNATQAECEAACVEAYVKETEQQACSEGCWSQNPQLEPEPELEPEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDNGKVVVFQTQPVVESLGHEGTRLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTSSKAKIESDELQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGFMVEPDWPLYPPPSHAFADSPPPYKLKLDLTKL", "length": 349 }, "evidence": [ { "id": "Q0VCT2", "url": "https://omabrowser.org/oma/group/Q0VCT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5HZE8-1", "protein_name": "Transmembrane protein 59-like", "gene_name": "Tmem59l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVALPLLLLLASPATPTPARDPFSPQLGDTQRCQQRCRQRHPGLPPAQPEPEGPSESPNNKAVLINACERGCRLFSICRFVARSSRPNATETECEAACTEAYVKAKEQQACSEGCWGQIPEPETQLEQKELALDPPSGSLSLRHLFTMLCSDLMSSAQDLISSTWTYSLQTDNRKTQPVVENFAFQGSRLQRVEVTWRGSHPKALEVHMDPMSPLEKVRRAKPHLKTSKAKVESEDQQESDFLSCMSRRSGLPRWVLFCCLFLSVLIILWLSCCTLVTTPGQHLKFQPLTAEQHKGLLVESNWPLYPPLPPAYEDSPPPYKLKLDLTTL", "length": 331 }, "evidence": [ { "id": "Q0VCT2", "url": "https://omabrowser.org/oma/group/Q0VCT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TNI2-1", "protein_name": "Transmembrane protein 59-like", "gene_name": "Tmem59l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVALPLLLLLASLVTPTPARDPFAPQLGDTQRCQQRCRQHHPGSPPAQPEPEGPSESPNNKAILISACERGCRLFSICRFVAKSSRPNATETECEAACTEAYVKAAEQRACSEGCWGQIPEPETQLEQKDLALDPPRGRLSLRYLFSMLCSDLMSSAQGFLSSSWTYSLQTDNRKVVVFQTQPVAENFAFQGSHLQRVEVTWRRSHPKALELHMDPVGPLDKVRKAKPRVKTSKAKVESEDQQESDFLSCMSRRSGLPRWVLFCCLFLSILIMLWLSCCTLVTTPGQHLKFQPLTAEQHKGLLVESDWPLYPPLPPPAYEDSTPPYKLKLDLTTL", "length": 337 }, "evidence": [ { "id": "Q0VCT2", "url": "https://omabrowser.org/oma/group/Q0VCT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UK28-1", "protein_name": "Transmembrane protein 59-like", "gene_name": "TMEM59L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQLRCRDRDLGPQPSQAGLEGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTECEAACVEAYVKEAEQQACSHGCWSQPAEPEPEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDNGKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTSSKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYKLKLDLTKL", "length": 342 }, "evidence": [ { "id": "Q0VCT2", "url": "https://omabrowser.org/oma/group/Q0VCT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q0VCT2", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "branching involved in ureteric bud morphogenesis", "id": "GO:0001658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001658", "evidence": [ { "database": "UniProtKB", "id": "Q0VCT2", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCT2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCT2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCT2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCT2" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Microbody targeting signal", "eco_id": "ECO_0000255", "start_pos": 347, "end_pos": 349, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 100 ], "o_linked_sites": [ 21 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCU0-1", "uniprot_ac": "Q0VCU0", "uniprot_id": "PCBP4_BOVIN", "mass": { "chemical_mass": 41542.0, "monoisotopic_mass": 41542.0 }, "refseq": { "ac": "NP_001068751", "name": "poly(rC)-binding protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068751" }, "gene_names": [ { "name": "PCBP4", "type": "recommended", "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ] }, { "name": "PCBP4", "type": "synonym", "evidence": [ { "id": "NP_001068751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068751" } ] } ], "protein_names": [ { "name": "Poly(rC)-binding protein 4", "type": "recommended", "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0/entry#names_and_taxonomy" } ] }, { "name": "Alpha-CP4", "type": "synonym", "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0/entry#names_and_taxonomy" } ] }, { "name": "alpha-CP4", "type": "synonym", "evidence": [ { "id": "NP_001068751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068751" } ] }, { "name": "poly(rC)-binding protein 4", "type": "synonym", "evidence": [ { "id": "NP_001068751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068751" } ] } ], "function": [ { "annotation": "Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCBP4", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0", "locus": { "chromosome": "22", "start_pos": 48977496, "end_pos": 48966895, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018622", "url": "https://www.ensembl.org/id/ENSBTAG00000018622" } ] } } ], "crossref": [ { "id": "Q0VCU0", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018622", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018622", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22517", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22520", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22520", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22523", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22523", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506889", "url": "https://www.ncbi.nlm.nih.gov/gene/506889", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506889", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TISTRKM", "url": "https://omabrowser.org/oma/group/TISTRKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCU0", "url": "https://www.orthodb.org/?gene=Q0VCU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068751", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCU0-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSDAGLEEEPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITISEGSCPERITTITGSTAAVFHAVSMIAFKLDEDLCAAPANGGNVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPNSTERAVTVSGVPDAIILCVRQICAVILESPPKGATIPYHPSLSLGTVLLSTNQGFSVQGQYGTVTPAEVTKLQQLSGHAVPFASPSMVPGLDPSTQTSSQEFLVPNDLIGCVIGRQGSKISEIRQMSGAHIKIGNQAEGAGERHVTITGSPVSIALAQYLITACLETAKSTSGGTPGSAPTDLPAPFSPPLTALPTAPPGLLGTPYAISLSNFIGLKPVPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFSPY", "length": 403, "header": "sp|Q0VCU0-1|PCBP4_BOVIN Isoform 1 of Poly(rC)-binding protein 4 OS=Bos taurus OX=9913 GN=PCBP4 PE=2 SV=1 CANONICAL=Q0VCU0-1" }, "isoforms": [ { "isoform_ac": "Q0VCU0-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0/entry#Q0VCU0-1", "sequence": { "sequence": "MSGSDAGLEEEPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITISEGSCPERITTITGSTAAVFHAVSMIAFKLDEDLCAAPANGGNVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPNSTERAVTVSGVPDAIILCVRQICAVILESPPKGATIPYHPSLSLGTVLLSTNQGFSVQGQYGTVTPAEVTKLQQLSGHAVPFASPSMVPGLDPSTQTSSQEFLVPNDLIGCVIGRQGSKISEIRQMSGAHIKIGNQAEGAGERHVTITGSPVSIALAQYLITACLETAKSTSGGTPGSAPTDLPAPFSPPLTALPTAPPGLLGTPYAISLSNFIGLKPVPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFSPY", "length": 403, "header": "sp|Q0VCU0-1|PCBP4_BOVIN Isoform 1 of Poly(rC)-binding protein 4 OS=Bos taurus OX=9913 GN=PCBP4 PE=2 SV=1 CANONICAL=Q0VCU0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 209, "start_aa": "Thr", "end_pos": 209, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr209", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 319, "start_aa": "Thr", "end_pos": 319, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506889", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506889", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" }, { "name": "negative regulation of mRNA splicing, via spliceosome", "id": "GO:0048025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048025", "evidence": [ { "database": "UniProtKB", "id": "Q0VCU0", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCU0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 403, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCU0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCU0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" }, { "id": "PRU00117", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KH 1", "eco_id": "ECO_0000255", "start_pos": 17, "end_pos": 67, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" }, { "id": "PRU00117", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KH 2", "eco_id": "ECO_0000255", "start_pos": 101, "end_pos": 154, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q0VCU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCU0" }, { "id": "PRU00117", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KH 3", "eco_id": "ECO_0000255", "start_pos": 241, "end_pos": 293, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 209, 319 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 390, "end_pos": 392 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCV7-1", "uniprot_ac": "Q0VCV7", "uniprot_id": "VEXIN_BOVIN", "mass": { "chemical_mass": 22246.0, "monoisotopic_mass": 22246.0 }, "refseq": { "ac": "NP_001069943", "name": "vexin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" }, "gene_names": [ { "name": "VXN", "type": "recommended", "evidence": [ { "id": "Q0VCV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ] }, { "name": "C14H8orf46", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] }, { "name": "C8orf46", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] }, { "name": "VXN", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] } ], "protein_names": [ { "name": "Vexin", "type": "recommended", "evidence": [ { "id": "Q0VCV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7/entry#names_and_taxonomy" } ] }, { "name": "chromosome 14 C8orf46 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] }, { "name": "uncharacterized protein C8orf46 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] }, { "name": "vexin", "type": "synonym", "evidence": [ { "id": "NP_001069943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943" } ] } ], "function": [ { "annotation": "Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7#function" }, { "database": "UniProtKB", "id": "Q8BG31", "url": "https://www.uniprot.org/uniprotkb/Q8BG31#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VXN", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7", "locus": { "chromosome": "14", "start_pos": 30774944, "end_pos": 30748671, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002192", "url": "https://www.ensembl.org/id/ENSBTAG00000002192" } ] } } ], "crossref": [ { "id": "Q0VCV7", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002192", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002192", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617724", "url": "https://www.ncbi.nlm.nih.gov/gene/617724", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617724", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617724", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DRWDTGD", "url": "https://omabrowser.org/oma/group/DRWDTGD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCV7", "url": "https://www.orthodb.org/?gene=Q0VCV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31520", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31520", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31520:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31520:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069943", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCV7-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHQIYSCSDENIEVFTTVIPSKVTSPARRRVKSSQHLLTKNVVIESDLYAPRPVELLPHRTDRRDGEGRWSGRFQNPRLQGPHPAKTPARPVGTSEPKSANLCGNRTYGKALMPPVARISVKAPTVLEAAAPGSENVAVLTRGSRHLKKMTEEFPTLPQGAEASLPLTGSAPCGMPSILRKMWTRHKKKSEYVGATNSAFEAD", "length": 203, "header": "sp|Q0VCV7-1|VEXIN_BOVIN Isoform 1 of Vexin OS=Bos taurus OX=9913 GN=VXN PE=2 SV=1 CANONICAL=Q0VCV7-1" }, "isoforms": [ { "isoform_ac": "Q0VCV7-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7/entry#Q0VCV7-1", "sequence": { "sequence": "MHQIYSCSDENIEVFTTVIPSKVTSPARRRVKSSQHLLTKNVVIESDLYAPRPVELLPHRTDRRDGEGRWSGRFQNPRLQGPHPAKTPARPVGTSEPKSANLCGNRTYGKALMPPVARISVKAPTVLEAAAPGSENVAVLTRGSRHLKKMTEEFPTLPQGAEASLPLTGSAPCGMPSILRKMWTRHKKKSEYVGATNSAFEAD", "length": 203, "header": "sp|Q0VCV7-1|VEXIN_BOVIN Isoform 1 of Vexin OS=Bos taurus OX=9913 GN=VXN PE=2 SV=1 CANONICAL=Q0VCV7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617724", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617724", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XHD5-1", "protein_name": "Vexin", "gene_name": "C2H8ORF46", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHQIYSCSDENLEVFTTVISSKSCSPARRRAKSAHHILTKSVVAVSDCQPHRPDKLQPHHGDLLQVLYREEEVHSLGHVRGGQQGPCSPKHVGITERETTKPCNHRSNGKPLPPSSLALPITAKPALTGSTMDDHPLAEDRRQRLRKMAEYDLTMTPGAEASLPLTGGSLYGTPSLLRKMWMKHKKKSEYLGATNSAFEAD", "length": 201 }, "evidence": [ { "id": "Q0VCV7", "url": "https://omabrowser.org/oma/group/Q0VCV7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZVT4-1", "protein_name": "Vexin", "gene_name": "Vxn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHQIYSCSDENIEVFTTVIPSKVPSPSRRRVKSSQHLLAKNVVIESDLYPPPRPLELLPQRCERRDTGDRRWLQTGRLQTARPPGTHPTKTPARPVGISEPKASNLCGNRAYGKSLIPPVARISVKTPAVVEVTAKGSENGAALGRGSRHLKKITEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD", "length": 207 }, "evidence": [ { "id": "Q0VCV7", "url": "https://omabrowser.org/oma/group/Q0VCV7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BG31-1", "protein_name": "Vexin", "gene_name": "Vxn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHQIYSCSDENIEVFTTVIPSKVSSSSRRRVKSSHHLLAKNVVIESDLYPPPRPLELLPQRCERRDTGDRRWLQTGRLQTARPPGAHPTKTPSRPVGISEPKTSNLCGNRAYGKSLIPPVARISVKAPAGAEVAAKGSEHGAVLGRGSRHLKKIAEEYPALPQGAEASLPLTGSTSCGVPGILRKMWTRHKKKSEYVGATNSAFEAD", "length": 207 }, "evidence": [ { "id": "Q0VCV7", "url": "https://omabrowser.org/oma/group/Q0VCV7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TAG6-1", "protein_name": "Vexin", "gene_name": "VXN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMHQIYSCSDENIEVFTTVIPSKVSSPARRRAKSSQHLLTKNVVIESDLYTHQPLELLPHRGDRRDPGDRRRFGRLQTARPPTAHPAKASARPVGISEPKTSNLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLMRGSRHLKKMTEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD", "length": 207 }, "evidence": [ { "id": "Q0VCV7", "url": "https://omabrowser.org/oma/group/Q0VCV7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "Q0VCV7", "url": "https://www.uniprot.org/uniprotkb/Q0VCV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCV7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 203, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCV7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCV7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCW6-1", "uniprot_ac": "Q0VCW6", "uniprot_id": "PNRC2_BOVIN", "mass": { "chemical_mass": 15656.0, "monoisotopic_mass": 15656.0 }, "refseq": { "ac": "NP_001070425", "name": "proline-rich nuclear receptor coactivator 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070425" }, "gene_names": [ { "name": "PNRC2", "type": "recommended", "evidence": [ { "id": "Q0VCW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ] }, { "name": "PNRC2", "type": "synonym", "evidence": [ { "id": "NP_001070425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070425" } ] } ], "protein_names": [ { "name": "Proline-rich nuclear receptor coactivator 2", "type": "recommended", "evidence": [ { "id": "Q0VCW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6/entry#names_and_taxonomy" } ] }, { "name": "proline-rich nuclear receptor coactivator 2", "type": "synonym", "evidence": [ { "id": "NP_001070425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070425" } ] } ], "function": [ { "annotation": "Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6#function" }, { "database": "UniProtKB", "id": "Q9NPJ4", "url": "https://www.uniprot.org/uniprotkb/Q9NPJ4#function" }, { "database": "UniProtKB", "id": "Q9CR73", "url": "https://www.uniprot.org/uniprotkb/Q9CR73#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNRC2", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6", "locus": { "chromosome": "2", "start_pos": 128926114, "end_pos": 128943207, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030435", "url": "https://www.ensembl.org/id/ENSBTAG00000030435" } ] } } ], "crossref": [ { "id": "Q0VCW6", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030435", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030435", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767836", "url": "https://www.ncbi.nlm.nih.gov/gene/767836", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767836", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767836", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNTTKNH", "url": "https://omabrowser.org/oma/group/RNTTKNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCW6", "url": "https://www.orthodb.org/?gene=Q0VCW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15365", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15365", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCW6-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGGERYNIPAPQTRNVSKNQQQLSRQKTKDQNSQMKIVHKKKERGHTYNSSSAAWQAMQNGGKNKNFPNNQNWNSSLSSPTLLFKSQTNQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV", "length": 139, "header": "sp|Q0VCW6-1|PNRC2_BOVIN Isoform 1 of Proline-rich nuclear receptor coactivator 2 OS=Bos taurus OX=9913 GN=PNRC2 PE=2 SV=1 CANONICAL=Q0VCW6-1" }, "isoforms": [ { "isoform_ac": "Q0VCW6-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6/entry#Q0VCW6-1", "sequence": { "sequence": "MGGGERYNIPAPQTRNVSKNQQQLSRQKTKDQNSQMKIVHKKKERGHTYNSSSAAWQAMQNGGKNKNFPNNQNWNSSLSSPTLLFKSQTNQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV", "length": 139, "header": "sp|Q0VCW6-1|PNRC2_BOVIN Isoform 1 of Proline-rich nuclear receptor coactivator 2 OS=Bos taurus OX=9913 GN=PNRC2 PE=2 SV=1 CANONICAL=Q0VCW6-1" }, "locus": { "chromosome": "2", "start_pos": 128940610, "end_pos": 128940194, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127676.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127676.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095376.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767836", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767836", "resource": "KEGG Pathway" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LXX9-1", "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "Pnrc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGGGERYNIPAPQSRNVSKNQQQHNRQKTKDQNSQMKMVPKKKERGHGYNPAAAARQAMQNGGKNKSLANNPSWNASLSSPSLLFKPQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSLNPSDKETMTFQLKTLLKVQV", "length": 139 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1P0D8-1", "protein_name": "Proline rich nuclear receptor coactivator 2", "gene_name": "PNRC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGGERFNVPVPQSRNITKNHQQLKNRQKNKDQNSQMKKTYMKKERGHGCNSLSGAWQAMQKAGKNNVHFPCNQNWSPNLSNRNLFFSPQTNQNYAGAKFSEPPSPSVLPKPPSHWVPVSFKPSDKEIMTFQLKTLLKVQA", "length": 141 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LST4-1", "protein_name": "Proline rich nuclear receptor coactivator 2", "gene_name": "PNRC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGGERYNIPAPQSRNVSKNQQQLNRQKTKDQNSQMKIVHKKKERGHTYNSSAAAWQAMQNGGKNKNFPNNQNWNSSLSSPTLLFKSQTNQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV", "length": 139 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q66HE1-1", "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "Pnrc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGGERYNIPDPQSRNASKNQQQHNRQKTKDQNSQMKIVHKKKERGHGYNPSAVQNGGKTKSLSNNSNWNASLSSPSLLFKSQASQNYAGAKFSEPPSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV", "length": 134 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CR73-1", "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "Pnrc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGGERYNIPDPQSRNASKNQEQQNRQKSKDQNSSQTKIAHKKKERGHGYNPAAAAWQAMQNGGKTKSLSNNSNWNAGLSSPSLLFKSQASQNYAGAKFSEPPSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV", "length": 140 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPJ4-1", "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "PNRC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV", "length": 139 }, "evidence": [ { "id": "Q0VCW6", "url": "https://omabrowser.org/oma/group/Q0VCW6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "Q0VCW6", "url": "https://www.uniprot.org/uniprotkb/Q0VCW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCW6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 139, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCW6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCW6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VCY3-1", "uniprot_ac": "Q0VCY3", "uniprot_id": "SURF6_BOVIN", "mass": { "chemical_mass": 40642.0, "monoisotopic_mass": 40642.0 }, "refseq": { "ac": "NP_001068997", "name": "surfeit locus protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068997" }, "gene_names": [ { "name": "SURF6", "type": "recommended", "evidence": [ { "id": "Q0VCY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ] }, { "name": "SURF6", "type": "synonym", "evidence": [ { "id": "NP_001068997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068997" } ] } ], "protein_names": [ { "name": "Surfeit locus protein 6", "type": "recommended", "evidence": [ { "id": "Q0VCY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3/entry#names_and_taxonomy" } ] }, { "name": "surfeit locus protein 6", "type": "synonym", "evidence": [ { "id": "NP_001068997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068997" } ] } ], "function": [ { "annotation": "Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SURF6", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3", "locus": { "chromosome": "11", "start_pos": 104240172, "end_pos": 104246931, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011554", "url": "https://www.ensembl.org/id/ENSBTAG00000011554" } ] } } ], "crossref": [ { "id": "Q0VCY3", "url": "https://alphafold.ebi.ac.uk/entry/Q0VCY3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011554", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011554", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511610", "url": "https://www.ncbi.nlm.nih.gov/gene/511610", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511610", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511610", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QKKRTDN", "url": "https://omabrowser.org/oma/group/QKKRTDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VCY3", "url": "https://www.orthodb.org/?gene=Q0VCY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14369:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14369:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04935", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04935", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VCY3-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSLLAKDAYLQGLAKKICSQPSAEPQKRKSAGKTQVSEAAAPPRKKRKKAQKKSRERERKTAKPKAQASAEKSEARKPEVAKEEEGATSSTRVPADGLAAEPDSLFALDVLRQRLHEKIQEARGQGSAKELSAAVLEKRRRRKQERDRKKRKRRELRAKEKAAKALEGAEATEPDLQVPREEAQAQPGLLFNKVEVTEEEPANKAQRRKEKRQKLKGNLTPLTGRNYRQLLERLQARQARLEDLRDRDAGQAQELEAKMRWTNLLYKAEGVRIRDDERLLQEALKRKEKRRAQRQRAWEKRTAHVVGKMQQRQDQRRQNLRKKKAAKAERRLEKARKKGRILPQDLERAGLA", "length": 353, "header": "sp|Q0VCY3-1|SURF6_BOVIN Isoform 1 of Surfeit locus protein 6 OS=Bos taurus OX=9913 GN=SURF6 PE=2 SV=1 CANONICAL=Q0VCY3-1" }, "isoforms": [ { "isoform_ac": "Q0VCY3-1", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3/entry#Q0VCY3-1", "sequence": { "sequence": "MTSLLAKDAYLQGLAKKICSQPSAEPQKRKSAGKTQVSEAAAPPRKKRKKAQKKSRERERKTAKPKAQASAEKSEARKPEVAKEEEGATSSTRVPADGLAAEPDSLFALDVLRQRLHEKIQEARGQGSAKELSAAVLEKRRRRKQERDRKKRKRRELRAKEKAAKALEGAEATEPDLQVPREEAQAQPGLLFNKVEVTEEEPANKAQRRKEKRQKLKGNLTPLTGRNYRQLLERLQARQARLEDLRDRDAGQAQELEAKMRWTNLLYKAEGVRIRDDERLLQEALKRKEKRRAQRQRAWEKRTAHVVGKMQQRQDQRRQNLRKKKAAKAERRLEKARKKGRILPQDLERAGLA", "length": 353, "header": "sp|Q0VCY3-1|SURF6_BOVIN Isoform 1 of Surfeit locus protein 6 OS=Bos taurus OX=9913 GN=SURF6 PE=2 SV=1 CANONICAL=Q0VCY3-1" }, "locus": { "chromosome": "11", "start_pos": 104246812, "end_pos": 104240667, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015353.3", "url": "https://www.ensembl.org/id/ENSBTAT00000015353.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015353.2", "url": "https://www.ensembl.org/id/ENSBTAP00000015353.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "site_lbl": "Ser133" }, { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "site_lbl": "Thr221" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511610", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511610", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F7F149-1", "protein_name": "Surfeit 6", "gene_name": "Surf6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTVRTKGSEAAGPPKKKRKKTQNKSRKQEEKTMEHKTKPLGKKSPTSSSAKKPGLSKQGSSGSLGSPEDSRGTAPDSVFALDFLRQRLHEKIQMARGQGGTKELSAATLEKRQRRKQERERKKRKRRELRAKQQVAEAEKKEEPVKAPPKMACKDLQESGLIFNKVEVAGEEPASKAQRKKEKRQQVKGNLTPLTGRNYRQLLDRLHARQGRVEELRDQDAGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRKWEKRSEHVVEKMQQRQDKRRQNLRKKKAARAERRLQKARKKGRVLPQDLERAGLS", "length": 326 }, "evidence": [ { "id": "Q0VCY3", "url": "https://omabrowser.org/oma/group/Q0VCY3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75683-1", "protein_name": "Surfeit locus protein 6", "gene_name": "SURF6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGLV", "length": 361 }, "evidence": [ { "id": "Q0VCY3", "url": "https://omabrowser.org/oma/group/Q0VCY3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P36080-1", "protein_name": "Ribosomal RNA-processing protein 14", "gene_name": "RRP14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSNSLEERLRANSSAFDGLLALIPAKYYYDEKSQEQWKAKKKTKEQSKNDKLKKLDPEQRDDETSSTLEVMKKKEKDAKPVVLPGEKFKHMKMQKQKEATSKVEGDSDLNVEVNDPMIIAPDEDEEEEEDIKVIFDDEGNEIPLESKKDTTEPDRSVEKKSITEEEKLQRKKNLEALRSKLQAKISDMKSKRKAPGSREAILAQRKRKEELKKRKRLESEQEQDQDEIASDSDMEDIDSDLENNSKKRFKKGKKDSEINADGVMFQNIIFDDGARATSDLQRLRKAGRTKGPAKNDVKSHLKLLEAKKNKMEAKDELEQIKQKEKEKWQKAMLQAEGIKIRDDEKLLRKAIKRKEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRKDNKGKKRNKQEKMKRKYVGSAVPKKRAGFEGRLKTGKKKGGPK", "length": 434 }, "evidence": [ { "id": "Q0VCY3", "url": "https://omabrowser.org/oma/group/Q0VCY3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P70279-1", "protein_name": "Surfeit locus protein 6", "gene_name": "Surf6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLLAKDTYLQDLAKKICAQPGPERQRSTWGVRTKGSEAAGAPKKKRKKTQKKSPEQEQKAMDHKTKALGKKPPTSSRPKNPMVSKQEKGLSSLGSPKDSQGTARESVFALDFLRQRLHEKIQLARGQGSTKELSAATLEKRQRRKQERERKKRKRKERQAKQQVAEAEKKEEPVEVTPKMACKELQESGLIFNKVEVTEEEPASKAQRKKEKRQKVKGNLTPLTGRNYRQLLDRLQARQGRLDELRDQDAAKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRKWEKRSEHVVEKMQQRQDKRRQNLRKKKAARAERRLQKAHKKGRVLPQDLERAGLS", "length": 355 }, "evidence": [ { "id": "Q0VCY3", "url": "https://omabrowser.org/oma/group/Q0VCY3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FLD3-1", "protein_name": "Surfeit locus protein 6", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTKTRGTDMTKKKGKHVSEMDFKTHQHTEFFDKLIELTPARFYLPDETERKWYPGLSKAQKARAKKKTNDNLKKAKRDKLDPEKSALTTLDLLKEKIEKERLASQKQKLKKKHADLREQKLEQEKSGTELPDDDSKKETDNNRLNDDDSKEETDNNRQKDDRSVTYEELRERLHRKIDELKGGRGGSDRPRSNERRKKNLPNKRKRDTVSEEKTVEEIKSADKGKGKLDVEEAAKDLTFGYVKIDDDEEHGKEKKKRRLSKARELERAMKLEAAKKDPEKGDVIAKKHSWKAATSRAAGIKVHDDPKLLKQSIHKDKKRQEKNAEKWKERIEGQQKFKVEKQQKRSGNIADRIEQNKMRKIAKREKKLLRPGFEGRKEGFINEGGN", "length": 386 }, "evidence": [ { "id": "Q0VCY3", "url": "https://omabrowser.org/oma/group/Q0VCY3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" }, { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q0VCY3", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VCY3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 353, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VCY3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VCY3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VCY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCY3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 45, "end_pos": 49, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 133, 221 ], "sequon_annotation_sites": [ { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VD01-1", "uniprot_ac": "Q0VD01", "uniprot_id": "IMP4_BOVIN", "mass": { "chemical_mass": 33681.0, "monoisotopic_mass": 33681.0 }, "refseq": { "ac": "NP_001069085", "name": "U3 small nucleolar ribonucleoprotein IMP4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" }, "gene_names": [ { "name": "IMP4", "type": "recommended", "evidence": [ { "id": "Q0VD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ] }, { "name": "IMP4", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" } ] } ], "protein_names": [ { "name": "U3 small nucleolar ribonucleoprotein protein IMP4", "type": "recommended", "evidence": [ { "id": "Q0VD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD01/entry#names_and_taxonomy" } ] }, { "name": "IMP4 homolog, U3 small nucleolar ribonucleoprotein", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" } ] }, { "name": "IMP4, U3 small nucleolar ribonucleoprotein, homolog", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" } ] }, { "name": "U3 small nucleolar ribonucleoprotein IMP4", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" } ] }, { "name": "U3 small nucleolar ribonucleoprotein protein IMP4", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" } ] }, { "name": "U3 snoRNP protein IMP4", "type": "synonym", "evidence": [ { "id": "NP_001069085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085" }, { "id": "Q0VD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD01/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01#function" }, { "database": "UniProtKB", "id": "Q96G21", "url": "https://www.uniprot.org/uniprotkb/Q96G21#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMP4", "url": "https://www.uniprot.org/uniprotkb/Q0VD01", "locus": { "chromosome": "2", "start_pos": 1323393, "end_pos": 1080651, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003225", "url": "https://www.ensembl.org/id/ENSBTAG00000003225" } ] } } ], "crossref": [ { "id": "Q0VD01", "url": "https://alphafold.ebi.ac.uk/entry/Q0VD01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003225", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003225", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513405", "url": "https://www.ncbi.nlm.nih.gov/gene/513405", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513405", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513405", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGTMSEQ", "url": "https://omabrowser.org/oma/group/IGTMSEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VD01", "url": "https://www.orthodb.org/?gene=Q0VD01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22734", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22734", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22734:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22734:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04427", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04427", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069085", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VD01-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRREARLRREYLYRKAREEAERTAQERKDKVRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTNHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTASEAKPHLIMHGFSSRLGKRVSDILRYLFPVPKDDSRRVITFANQDDYISFRHHVYKKTNHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTAHKRVFLSAE", "length": 291, "header": "sp|Q0VD01-1|IMP4_BOVIN Isoform 1 of U3 small nucleolar ribonucleoprotein protein IMP4 OS=Bos taurus OX=9913 GN=IMP4 PE=2 SV=1 CANONICAL=Q0VD01-1" }, "isoforms": [ { "isoform_ac": "Q0VD01-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD01/entry#Q0VD01-1", "sequence": { "sequence": "MLRREARLRREYLYRKAREEAERTAQERKDKVRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTNHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTASEAKPHLIMHGFSSRLGKRVSDILRYLFPVPKDDSRRVITFANQDDYISFRHHVYKKTNHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTAHKRVFLSAE", "length": 291, "header": "sp|Q0VD01-1|IMP4_BOVIN Isoform 1 of U3 small nucleolar ribonucleoprotein protein IMP4 OS=Bos taurus OX=9913 GN=IMP4 PE=2 SV=1 CANONICAL=Q0VD01-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513405", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513405", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "C7G018-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein", "gene_name": "imp4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLRRNARLRQEYLYRKNLEGADKEDYEKKRRIKKALDEGKPIPTELVDFEFKHRDEMKLDKLDGNRPKSIDDEYARAGIQDPKVLVTTSREPSSRLIQFTKELRMLFPNSQKMNRGAHVVKELVDACRANDVTDLVIAHEHRGEPVGLVISHLPYGPTAYFEIKNCVMIHDIDEATPPSLAFPHLIFHNFTTPLGERTENILKYLFPVPKDDSRRVVTFSNDNDFISFRHHIYEKDGYKNVILKEIGPRFELKLYKIQLGTLDQDEADLEWVYKPYMNSTKNRLFL", "length": 286 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "F1RXX3-1", "protein_name": "IMP U3 small nucleolar ribonucleoprotein 4", "gene_name": "IMP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRREARLRREYLYRKAREEAQRTAQERKDKVRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTNHMDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTASEAKPHLIMHGFSSRLGKRVSDILRYLFPVPKDDSRRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFEMKLYMIRLGTLEQEATADVEWRWHPYTNTAHKRVFLSAE", "length": 291 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HXD9-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "Imp4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRREARLRREYLYRKAREDAQRSIQEKKERVKRALEENQLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKIMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFTSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSAE", "length": 291 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53941-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "IMP4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLRRQARERREYLYRKAQELQDSQLQQKRQIIKQALAQGKPLPKELAEDESLQKDFRYDQSLKESEEADDLQVDDEYAATSGIMDPRIIVTTSRDPSTRLSQFAKEIKLLFPNAVRLNRGNYVMPNLVDACKKSGTTDLVVLHEHRGVPTSLTISHFPHGPTAQFSLHNVVMRHDIINAGNQSEVNPHLIFDNFTTALGKRVVCILKHLFNAGPKKDSERVITFANRGDFISVRQHVYVRTREGVEIAEVGPRFEMRLFELRLGTLENKDADVEWQLRRFIRTANKKDYL", "length": 290 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5PQR5-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "Imp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRREARLRREYLYRKAREEAQRSVQEKKERVKRALEENQLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSAE", "length": 291 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHZ7-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "Imp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRREARLRREYLYRKAREEAQRSVQEKKERVKRALEENQLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSAE", "length": 291 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96G21-1", "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "IMP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRREARLRREYLYRKAREEAQRSAQERKERLRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSTE", "length": 291 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9S826-1", "protein_name": "Ribosomal RNA processing Brix domain protein", "gene_name": "IMP4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MQRRLVRLKKEYIYRKSLEGDERKVYEQKRLIREALQEGKPIPTELRNVEAKLRQEIDLEDQNTAVPRSHIDDEYANATEADPKILLTTSRNPSAPLIRFTKELKFVFPNSQRINRGSQVISEIIETARSHDFTDVILVHEHRGVPDGLIISHLPFGPTAYFGLLNVVTRHDISDKKSIGKMPEQYPHLIFNNFTTQMGQRVGNILKHIFPAPKLDAKRIVTFSNQSDYISFRNHVYDKGEGGPKSIELKEIGPRFELRLYQVKLGTVEQNEAEIEWVIRPYMNTSKKRKFIGE", "length": 294 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VBY2-1", "protein_name": "Brix domain-containing protein", "gene_name": "Dmel\\CG11920", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRKQARQRREYLYNKALTERLKSKQKIQETVVKSINENKAIGSKNVKKSLTAYKSLKYADEGVDDRTVNDEYHYAGCEDPKIMLTTSHNPSSRLKMFMKELRLIIPNAQQMNRGNYQLTTLMHACRANNVTDFLIVHEHRGIPDSLVVCHLPYGPTAFFNISDVVMRHDIPDIGHMSEQKPHLIFNNFKTPIGLRTVKILKHLFPVPKENSQRVMSFLNHNDSIIFRHHQYKYVNKELELTEVGPRFSLKLYQIKLGTLENIKAADTEWINRPYMNTSQKRLIFSNDPGIINKDTEA", "length": 298 }, "evidence": [ { "id": "Q0VD01", "url": "https://omabrowser.org/oma/group/Q0VD01/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" }, { "name": "Mpp10 complex", "id": "GO:0034457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034457", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" }, { "name": "rRNA primary transcript binding", "id": "GO:0042134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042134", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q0VD01", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VD01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VD01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VD01" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD01" }, { "id": "PRU00034", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00034" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Brix", "eco_id": "ECO_0000255", "start_pos": 83, "end_pos": 264, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VD30-1", "uniprot_ac": "Q0VD30", "uniprot_id": "CCZ1_BOVIN", "mass": { "chemical_mass": 55502.0, "monoisotopic_mass": 55502.0 }, "refseq": { "ac": "NP_001068960", "name": "vacuolar fusion protein CCZ1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" }, "gene_names": [ { "name": "CCZ1", "type": "recommended", "evidence": [ { "id": "Q0VD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ] }, { "name": "C25H7orf28A", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] }, { "name": "C7orf28A", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] }, { "name": "CCZ1", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] } ], "protein_names": [ { "name": "Vacuolar fusion protein CCZ1 homolog", "type": "recommended", "evidence": [ { "id": "Q0VD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD30/entry#names_and_taxonomy" } ] }, { "name": "CCZ1 homolog, vacuolar protein trafficking and biogenesis associated", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] }, { "name": "CCZ1 vacuolar protein trafficking and biogenesis associated homolog", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] }, { "name": "vacuolar fusion protein CCZ1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960" } ] } ], "function": [ { "annotation": "Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30#function" }, { "database": "UniProtKB", "id": "P86791", "url": "https://www.uniprot.org/uniprotkb/P86791#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCZ1", "url": "https://www.uniprot.org/uniprotkb/Q0VD30", "locus": { "chromosome": "25", "start_pos": 37980263, "end_pos": 37964318, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003288", "url": "https://www.ensembl.org/id/ENSBTAG00000003288" } ] } } ], "crossref": [ { "id": "Q0VD30", "url": "https://alphafold.ebi.ac.uk/entry/Q0VD30", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003288", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003288", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511088", "url": "https://www.ncbi.nlm.nih.gov/gene/511088", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511088", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511088", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DCQALHT", "url": "https://omabrowser.org/oma/group/DCQALHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VD30", "url": "https://www.orthodb.org/?gene=Q0VD30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13056:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13056:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19032", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19032", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19033", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19033", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068960", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VD30-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAASGAGAGAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYYPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLRAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEALHLIVYKAMSAAVCFMIDASIQPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 480, "header": "sp|Q0VD30-1|CCZ1_BOVIN Isoform 1 of Vacuolar fusion protein CCZ1 homolog OS=Bos taurus OX=9913 GN=CCZ1 PE=2 SV=1 CANONICAL=Q0VD30-1" }, "isoforms": [ { "isoform_ac": "Q0VD30-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD30/entry#Q0VD30-1", "sequence": { "sequence": "MAAAASGAGAGAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYYPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLRAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEALHLIVYKAMSAAVCFMIDASIQPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 480, "header": "sp|Q0VD30-1|CCZ1_BOVIN Isoform 1 of Vacuolar fusion protein CCZ1 homolog OS=Bos taurus OX=9913 GN=CCZ1 PE=2 SV=1 CANONICAL=Q0VD30-1" }, "locus": { "chromosome": "25", "start_pos": 37979983, "end_pos": 37964408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004259.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004259.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004259.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004259.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 264, "end_pos": 264, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "site_lbl": "Ser264" }, { "start_pos": 74, "end_pos": 74, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "site_lbl": "Ser74" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511088", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511088", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140UHX9-1", "protein_name": "CCZ1 homolog, vacuolar protein trafficking and biogenesis associated", "gene_name": "Ccz1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAAAGTGTWAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPVRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTQLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRADEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 480 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7FVR3-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog isoform X1", "gene_name": "LOC100769148", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAAAGTGTWAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMIMVVRNPIIEKQSKDGKPIVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKLLKERLQKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHMEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTQLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRRAVYMKLSHLKLSYRADEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 495 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "C0Z274-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog B", "gene_name": "CCZ1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGMASMSSGTESLRLCVFDLRRGQHEGQELDKILFFYPPDLTFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMIVEKNKEIEAVWRIDALRRVLKEVHSLFVMFQGSIRALLEKEPTGGLVRSHLYPFITDYLNDLFVGKKQQLPSFRDTLKERGTVQMLTLARDAALEVQSLVGVLDSCAGTVRCHSVILFHDLLVSTTLSPDDTVDLFAFSVMRLTTNALSSGTSSWSYLRKGSGSPQISSRSTTVPPLGSGGTLPSGNGSSTGRVIRPLQHDKWSKGKDGFLVTDIWGLDATPTILIQKTQESFYLLTYQYKSLTLVLLVPIAAIVNGELDISFVKQQVIENASTKILKVEEKLSKGWGGENAYHVSGYRYLLVDNDMEVSRASPPGKVATLAKESLLALNKLREEVDTEKNRSKQEKDMEICIRAKNNTWVIARLNRGKELYMALEKASETLLDATDSVQRFSNRYCSGAFPMD", "length": 497 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "I3L7N6-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "CCZ1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAATAGAGAGAGAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYYPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEDNFWMVMVVRNPIIEKQSKDGKPIVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLRAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEALHLIVYKAMSAAVCFMIDASIQPTLDFCRRLDGIVGPQLTVLASDICEQFNVNKRISGSEKEPQFKYIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTREDEDEEVIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 482 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P86791-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "CCZ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAAGAGSGPWAAQEKQFPPALLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVIEYQEEELLDKVYSSVLRQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLNIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPDAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASVHPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDRRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 482 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54IQ5-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVPIVETSLHYFVIYCSKLGQKEGTEHEKILFFYPPTINIGEQTNSVGISEAYVLFTKQFSPGQPCEFIHTKKSTLALLHPEEDIWMVLSVYNPTGITGKDNKREYIEDEVDDIILMKTIQQIYQTWQTFNGSIMSLASKTSYDNVRKRLESFVKPYIQQIQFDQLDLFTSLDGIKFLPLNKNVYLTIFGYINSVDLHFQSTLSSFRFGLVLYKDNLILSSLEQNETRILYNYLINMVKVGPDINSSNSMIVKNNSNNIPIWQTKGVRTGFMIQKDSLPMVWLGGKPQAMIVYEQKDTFLLFLIDPSDLPQLPFEDLSASLVQNFEFVNLTLEQHYAKKANFDEQYKYIYFNQMNLAIRSPIKPKGPELNKETMKLLNEIHADFEGGLSSEIIVKTQQDRWIVAKKIDFREFYIMFDNKNSSILEINEEVKNATTKFFKFLFTD", "length": 445 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8C1Y8-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "Ccz1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAAGPGAWAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPVRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTPLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRADEDEEIIVKAMSDYWVVGKKSDQRELYVILSQKNANLIEVNEEVKKLCATQFNNIFFLD", "length": 480 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZL5-1", "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "Ccz1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAKLLQRVEITLRSFYIFNSTFGQVEGEEHKKVLFYHPNDIELNTKIKDVGLSEAIIRFTGTFTSEDDCQALHTQKTTQLFYQPEPGYWLVLVLNVPKEVRLKEGVEVADYRGAEISDRIYRAILRQCYQMFRFQNGCFSSCGSEEPNPDKRRELLCQKLLQFYDQHLTNLRDPAQCDIIDMLHSIQYLPLDKTLFLRAQNFGTLCETFPDIKESIMLYQEQVLCGGKLSPEDLHCVHSYVVQHVLKVEASSSTIAVSPSLKRSISECQVGGFVRSRQKVAGDEHDAVNEEDHPMKVYVTLDKEAKPYYLLIYRALHITLCLFLNADQVAPKQDLYDDLHAYMAPQLTSLARDISSELTKEAVGAAGQDNSSGNSETAPKYLFINEQSLQHHTNFQRHLPQGLPRNVLSIIADLANGSGKAEMESAPAEEVQVKTTNDYWIVKRRCNYRQYYVILCNSKATLLDVTQEARRIFEQELTDDVFFDK", "length": 485 }, "evidence": [ { "id": "Q0VD30", "url": "https://omabrowser.org/oma/group/Q0VD30/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vacuolar transport", "id": "GO:0007034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007034", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "pmid": "" }, { "name": "Mon1-Ccz1 complex", "id": "GO:0035658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035658", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q0VD30", "url": "https://www.uniprot.org/uniprotkb/Q0VD30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VD30-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 480, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VD30-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VD30" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 74, 264 ], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VD31-1", "uniprot_ac": "Q0VD31", "uniprot_id": "FBXL4_BOVIN", "mass": { "chemical_mass": 70295.0, "monoisotopic_mass": 70295.0 }, "refseq": { "ac": "NP_001069527", "name": "F-box/LRR-repeat protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069527" }, "gene_names": [ { "name": "FBXL4", "type": "recommended", "evidence": [ { "id": "Q0VD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ] }, { "name": "FBXL4", "type": "synonym", "evidence": [ { "id": "NP_001069527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069527" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 4", "type": "recommended", "evidence": [ { "id": "Q0VD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD31/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 4", "type": "synonym", "evidence": [ { "id": "Q0VD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD31/entry#names_and_taxonomy" } ] }, { "name": "F-box/LRR-repeat protein 4", "type": "synonym", "evidence": [ { "id": "NP_001069527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069527" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors. Also rescues mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31#function" }, { "database": "UniProtKB", "id": "Q8BH70", "url": "https://www.uniprot.org/uniprotkb/Q8BH70#function" }, { "database": "UniProtKB", "id": "Q9UKA2", "url": "https://www.uniprot.org/uniprotkb/Q9UKA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL4", "url": "https://www.uniprot.org/uniprotkb/Q0VD31", "locus": { "chromosome": "9", "start_pos": 50887401, "end_pos": 50809460, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005729", "url": "https://www.ensembl.org/id/ENSBTAG00000005729" } ] } } ], "crossref": [ { "id": "Q0VD31", "url": "https://alphafold.ebi.ac.uk/entry/Q0VD31", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22117", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22117", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535452", "url": "https://www.ncbi.nlm.nih.gov/gene/535452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q0VD31", "url": "https://www.orthodb.org/?gene=Q0VD31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069527", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VD31-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPVFPMLTVLTMFYYMCLRRRARTATRGEIMNSHRTVESNSRTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSAPVPFKRTPANFQSQDYVELAFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPGPPAEVRWETLWSEKPTKVNASQARQFKPCIKQINFPTNLIRLEINSSLLDYYTELDAVVLHGMKDKPMLSLKTSLIDMNDLDEDDYEEKDDCEIDNLNKKFSSTALREGPSNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLNQHCCDPLQYIHLNLQPYWAKLNDTSLEFLQARCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEIISEMCPNLQDLNLSSCDKLPPQAFSHIAKLCGLKRLVLYRTKVEQTALLSILNFCSDLQHLSLGSCVMIEDYDVTASMIGAKCKKLRTLDLWRCKNITESGIAELASGCPLLEELDLGWCPTLQSSTGCFARLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLRQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELSASFPKVFIKKSFTQ", "length": 621, "header": "sp|Q0VD31-1|FBXL4_BOVIN Isoform 1 of F-box/LRR-repeat protein 4 OS=Bos taurus OX=9913 GN=FBXL4 PE=2 SV=1 CANONICAL=Q0VD31-1" }, "isoforms": [ { "isoform_ac": "Q0VD31-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD31/entry#Q0VD31-1", "sequence": { "sequence": "MSPVFPMLTVLTMFYYMCLRRRARTATRGEIMNSHRTVESNSRTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSAPVPFKRTPANFQSQDYVELAFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPGPPAEVRWETLWSEKPTKVNASQARQFKPCIKQINFPTNLIRLEINSSLLDYYTELDAVVLHGMKDKPMLSLKTSLIDMNDLDEDDYEEKDDCEIDNLNKKFSSTALREGPSNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLNQHCCDPLQYIHLNLQPYWAKLNDTSLEFLQARCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEIISEMCPNLQDLNLSSCDKLPPQAFSHIAKLCGLKRLVLYRTKVEQTALLSILNFCSDLQHLSLGSCVMIEDYDVTASMIGAKCKKLRTLDLWRCKNITESGIAELASGCPLLEELDLGWCPTLQSSTGCFARLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLRQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELSASFPKVFIKKSFTQ", "length": 621, "header": "sp|Q0VD31-1|FBXL4_BOVIN Isoform 1 of F-box/LRR-repeat protein 4 OS=Bos taurus OX=9913 GN=FBXL4 PE=2 SV=1 CANONICAL=Q0VD31-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535452", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "Q0VD31", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VD31-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 621, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VD31-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VD31" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD31" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 277, "end_pos": 332, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 333, "end_pos": 335 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 491, "end_pos": 493 }, { "start_pos": 543, "end_pos": 545 }, { "start_pos": 557, "end_pos": 559 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VD34-1", "uniprot_ac": "Q0VD34", "uniprot_id": "PHYIP_BOVIN", "mass": { "chemical_mass": 37561.0, "monoisotopic_mass": 37561.0 }, "refseq": { "ac": "NP_001069883", "name": "phytanoyl-CoA hydroxylase-interacting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" }, "gene_names": [ { "name": "PHYHIP", "type": "recommended", "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ] }, { "name": "PHYHIP", "type": "synonym", "evidence": [ { "id": "NP_001069883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" } ] } ], "protein_names": [ { "name": "Phytanoyl-CoA hydroxylase-interacting protein", "type": "recommended", "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34/entry#names_and_taxonomy" } ] }, { "name": "PAHX-AP1", "type": "synonym", "evidence": [ { "id": "NP_001069883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" }, { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34/entry#names_and_taxonomy" } ] }, { "name": "PAHXAP1", "type": "synonym", "evidence": [ { "id": "NP_001069883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" }, { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34/entry#names_and_taxonomy" } ] }, { "name": "Phytanoyl-CoA hydroxylase-associated protein 1", "type": "synonym", "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34/entry#names_and_taxonomy" } ] }, { "name": "phytanoyl-CoA hydroxylase-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" } ] }, { "name": "phytanoyl-CoA hydroxylase-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001069883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883" } ] } ], "function": [ { "annotation": "Its interaction with PHYH suggests a role in the development of the central system.", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHYHIP", "url": "https://www.uniprot.org/uniprotkb/Q0VD34", "locus": { "chromosome": "8", "start_pos": 69531552, "end_pos": 69543759, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015757", "url": "https://www.ensembl.org/id/ENSBTAG00000015757" } ] } } ], "crossref": [ { "id": "Q0VD34", "url": "https://alphafold.ebi.ac.uk/entry/Q0VD34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015757", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015757", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616243", "url": "https://www.ncbi.nlm.nih.gov/gene/616243", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616243", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616243", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SPGDHFC", "url": "https://omabrowser.org/oma/group/SPGDHFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VD34", "url": "https://www.orthodb.org/?gene=Q0VD34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15698", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15698", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15698:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15698:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VD34-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELLSTPHSIEVSNITCDSFRISWTMENSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330, "header": "sp|Q0VD34-1|PHYIP_BOVIN Isoform 1 of Phytanoyl-CoA hydroxylase-interacting protein OS=Bos taurus OX=9913 GN=PHYHIP PE=2 SV=1 CANONICAL=Q0VD34-1" }, "isoforms": [ { "isoform_ac": "Q0VD34-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD34/entry#Q0VD34-1", "sequence": { "sequence": "MELLSTPHSIEVSNITCDSFRISWTMENSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330, "header": "sp|Q0VD34-1|PHYIP_BOVIN Isoform 1 of Phytanoyl-CoA hydroxylase-interacting protein OS=Bos taurus OX=9913 GN=PHYHIP PE=2 SV=1 CANONICAL=Q0VD34-1" }, "locus": { "chromosome": "8", "start_pos": 69540016, "end_pos": 69533166, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020921.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020921.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020921.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020921.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 14, "start_aa": "Asn", "end_pos": 14, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn14", "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 325, "start_aa": "Asn", "end_pos": 325, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn325", "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616243", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616243", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GUY0-1", "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "Phyhip", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNVLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELIFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330 }, "evidence": [ { "id": "Q0VD34", "url": "https://omabrowser.org/oma/group/Q0VD34/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q568Z9-1", "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "Phyhip", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNVLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELIFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330 }, "evidence": [ { "id": "Q0VD34", "url": "https://omabrowser.org/oma/group/Q0VD34/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0S0-1", "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "Phyhip", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNVLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELIFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330 }, "evidence": [ { "id": "Q0VD34", "url": "https://omabrowser.org/oma/group/Q0VD34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92561-1", "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "PHYHIP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "length": 330 }, "evidence": [ { "id": "Q0VD34", "url": "https://omabrowser.org/oma/group/Q0VD34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine kinase binding", "id": "GO:1990782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990782", "evidence": [ { "database": "UniProtKB", "id": "Q0VD34", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VD34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 330, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VD34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VD34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VD34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD34" }, { "id": "PRU00316", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00316" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000255", "start_pos": 6, "end_pos": 115, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": "Asn14" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 14, 325 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 325, "end_pos": 327 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VD38-1", "uniprot_ac": "Q0VD38", "uniprot_id": "TM278_BOVIN", "mass": { "chemical_mass": 17853.0, "monoisotopic_mass": 17853.0 }, "refseq": { "ac": "NP_001070426", "name": "transmembrane protein 278", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070426" }, "gene_names": [ { "name": "TMEM278", "type": "recommended", "evidence": [ { "id": "Q0VD38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD38" } ] }, { "name": "TMEM278", "type": "synonym", "evidence": [ { "id": "NP_001070426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070426" } ] }, { "name": "TMEM88B", "type": "synonym", "evidence": [ { "id": "NP_001070426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070426" }, { "id": "Q0VD38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD38" } ] } ], "protein_names": [ { "name": "Transmembrane protein 278", "type": "recommended", "evidence": [ { "id": "Q0VD38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD38/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 88B", "type": "synonym", "evidence": [ { "id": "Q0VD38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD38/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 278", "type": "synonym", "evidence": [ { "id": "NP_001070426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070426" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VD38", "url": "https://www.uniprot.org/uniprotkb/Q0VD38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM278", "url": "https://www.uniprot.org/uniprotkb/Q0VD38", "locus": {} } ], "crossref": [ { "id": "Q0VD38", "url": "https://alphafold.ebi.ac.uk/entry/Q0VD38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023784", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023784", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767837", "url": "https://www.ncbi.nlm.nih.gov/gene/767837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767837", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767837", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EEQLCAW", "url": "https://omabrowser.org/oma/group/EEQLCAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q0VD38", "url": "https://www.orthodb.org/?gene=Q0VD38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28628:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28628:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27917", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27917", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VD38", "url": "https://www.uniprot.org/uniprotkb/Q0VD38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VD38-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDQERETEEDEGGDPSDTAPMLPQRLPDHQASDLMSPGWASLAARGLGTLLFQGWALARLLLHLLLPAAVFLLVLLPAAAVVYLGFLCHSRVHPAPRPACRALLSDRGSAAVIVLGFLSLPPLLVLASAARARLARRLHSLLPPPTWSPGPHRQSDGEKQLCAWV", "length": 166, "header": "sp|Q0VD38-1|TM278_BOVIN Isoform 1 of Transmembrane protein 278 OS=Bos taurus OX=9913 GN=TMEM278 PE=2 SV=1 CANONICAL=Q0VD38-1" }, "isoforms": [ { "isoform_ac": "Q0VD38-1", "url": "https://www.uniprot.org/uniprotkb/Q0VD38/entry#Q0VD38-1", "sequence": { "sequence": "MSDQERETEEDEGGDPSDTAPMLPQRLPDHQASDLMSPGWASLAARGLGTLLFQGWALARLLLHLLLPAAVFLLVLLPAAAVVYLGFLCHSRVHPAPRPACRALLSDRGSAAVIVLGFLSLPPLLVLASAARARLARRLHSLLPPPTWSPGPHRQSDGEKQLCAWV", "length": 166, "header": "sp|Q0VD38-1|TM278_BOVIN Isoform 1 of Transmembrane protein 278 OS=Bos taurus OX=9913 GN=TMEM278 PE=2 SV=1 CANONICAL=Q0VD38-1" }, "locus": { "chromosome": "16", "start_pos": 51122158, "end_pos": 51120851, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000042400.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767837", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767837", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NKF7-1", "protein_name": "Transmembrane protein 278", "gene_name": "TMEM278", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEQGRETEEEEGGGGASDTAPMLPRGPPDHQASALTCPGWSGPPLLPGRLLAGLLLHLLLPAAAFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALFSDRGSAALIVFGLLSLPPLLVLASAVRARLARRLRPLLPPPAGTPGPRRPPGRPDEDEQLCAWV", "length": 163 }, "evidence": [ { "id": "Q0VD38", "url": "https://omabrowser.org/oma/group/Q0VD38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D4AAB3-1", "protein_name": "Transmembrane protein 88B", "gene_name": "Tmem278", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDQERETEEDEGVTSDTAPMLPRRRPTDYHISVLATQGLRTLMLSARALAGFLLHLLLPGTVFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALLSDRGSAALIVFGFLSLPPLLVLASAARSLLVRRLHLVLPTPARTPDPRRLPRGSEDLADEEKHLCAWV", "length": 165 }, "evidence": [ { "id": "Q0VD38", "url": "https://omabrowser.org/oma/group/Q0VD38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TYP4-1", "protein_name": "Transmembrane protein 278", "gene_name": "Tmem278", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEQERETEEDEGVASDTAPMLPRRRPTDYHISVLAPILATRGLGTLVLSGRALVGFLLHLLLPGTVFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALLSDRGSAALIVFGLLSLPPLVVLAAAARSLLVRRLRPALPDPARTPAPRRPPRSSGDLADGHPDEDKQLCAWV", "length": 173 }, "evidence": [ { "id": "Q0VD38", "url": "https://omabrowser.org/oma/group/Q0VD38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q0VD38", "url": "https://www.uniprot.org/uniprotkb/Q0VD38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "Q0VD38", "url": "https://www.uniprot.org/uniprotkb/Q0VD38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VD38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VD38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VD38" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q0VFX8-1", "uniprot_ac": "Q0VFX8", "uniprot_id": "CRIP2_BOVIN", "mass": { "chemical_mass": 22634.0, "monoisotopic_mass": 22634.0 }, "refseq": { "ac": "NP_001073117", "name": "cysteine-rich protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073117" }, "gene_names": [ { "name": "CRIP2", "type": "recommended", "evidence": [ { "id": "Q0VFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" } ] }, { "name": "CRIP2", "type": "synonym", "evidence": [ { "id": "NP_001073117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073117" } ] } ], "protein_names": [ { "name": "Cysteine-rich protein 2", "type": "recommended", "evidence": [ { "id": "Q0VFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8/entry#names_and_taxonomy" } ] }, { "name": "CRP-2", "type": "synonym", "evidence": [ { "id": "NP_001073117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073117" }, { "id": "Q0VFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8/entry#names_and_taxonomy" } ] }, { "name": "cysteine-rich protein 2", "type": "synonym", "evidence": [ { "id": "NP_001073117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073117" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q0VFX8", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRIP2", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8", "locus": { "chromosome": "21", "start_pos": 69749061, "end_pos": 69743987, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051673", "url": "https://www.ensembl.org/id/ENSBTAG00000051673" } ] } } ], "crossref": [ { "id": "Q0VFX8", "url": "https://alphafold.ebi.ac.uk/entry/Q0VFX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09476", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09476", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09478", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09478", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "780821", "url": "https://www.ncbi.nlm.nih.gov/gene/780821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:780821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q0VFX8", "url": "https://www.orthodb.org/?gene=Q0VFX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073117", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q0VFX8", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0VFX8-1", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASKCPKCDKTVYFAEKVSSLGKDWHRFCLRCEHCSKTLTPGGHAEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPSAEKPQVTGPIEVPVARTEERKASGPPKGPSKASSVTTFTGEPNMCPRCNKRVYFAEKVTSLGKDWHRPCLRCERCGKTLTPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDKDPEGKAQP", "length": 208, "header": "sp|Q0VFX8-1|CRIP2_BOVIN Isoform 1 of Cysteine-rich protein 2 OS=Bos taurus OX=9913 GN=CRIP2 PE=2 SV=1 CANONICAL=Q0VFX8-1" }, "isoforms": [ { "isoform_ac": "Q0VFX8-1", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8/entry#Q0VFX8-1", "sequence": { "sequence": "MASKCPKCDKTVYFAEKVSSLGKDWHRFCLRCEHCSKTLTPGGHAEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPSAEKPQVTGPIEVPVARTEERKASGPPKGPSKASSVTTFTGEPNMCPRCNKRVYFAEKVTSLGKDWHRPCLRCERCGKTLTPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDKDPEGKAQP", "length": 208, "header": "sp|Q0VFX8-1|CRIP2_BOVIN Isoform 1 of Cysteine-rich protein 2 OS=Bos taurus OX=9913 GN=CRIP2 PE=2 SV=1 CANONICAL=Q0VFX8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 104, "end_pos": 104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q0VFX8", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" } ], "site_lbl": "Ser104" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:780821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780821", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q0VFX8", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q0VFX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q0VFX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q0VFX8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q0VFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 1", "eco_id": "ECO_0000255", "start_pos": 5, "end_pos": 57, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q0VFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VFX8" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 2", "eco_id": "ECO_0000255", "start_pos": 126, "end_pos": 178, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 104 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q10568-1", "uniprot_ac": "Q10568", "uniprot_id": "CPSF2_BOVIN", "mass": { "chemical_mass": 88417.0, "monoisotopic_mass": 88417.0 }, "refseq": { "ac": "NP_787002", "name": "cleavage and polyadenylation specificity factor subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" }, "gene_names": [ { "name": "CPSF2", "type": "recommended", "evidence": [ { "id": "Q10568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ] }, { "name": "CPSF100", "type": "synonym", "evidence": [ { "id": "Q10568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ] }, { "name": "CPSF2", "type": "synonym", "evidence": [ { "id": "NP_787002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" } ] } ], "protein_names": [ { "name": "Cleavage and polyadenylation specificity factor subunit 2", "type": "recommended", "evidence": [ { "id": "Q10568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10568/entry#names_and_taxonomy" } ] }, { "name": "CPSF 100 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_787002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" }, { "id": "Q10568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10568/entry#names_and_taxonomy" } ] }, { "name": "Cleavage and polyadenylation specificity factor 100 kDa subunit", "type": "synonym", "evidence": [ { "id": "Q10568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10568/entry#names_and_taxonomy" } ] }, { "name": "cleavage and polyadenylation specific factor 2, 100kDa", "type": "synonym", "evidence": [ { "id": "NP_787002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" } ] }, { "name": "cleavage and polyadenylation specificity factor 100 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_787002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" } ] }, { "name": "cleavage and polyadenylation specificity factor subunit 2", "type": "synonym", "evidence": [ { "id": "NP_787002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002" } ] } ], "function": [ { "annotation": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPSF2", "url": "https://www.uniprot.org/uniprotkb/Q10568", "locus": { "chromosome": "21", "start_pos": 56842217, "end_pos": 56809062, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010227", "url": "https://www.ensembl.org/id/ENSBTAG00000010227" } ] } } ], "crossref": [ { "id": "Q10568", "url": "https://alphafold.ebi.ac.uk/entry/Q10568", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "327689", "url": "https://www.ncbi.nlm.nih.gov/gene/327689", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q10568", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q10568*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:327689", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:327689", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSRHNME", "url": "https://omabrowser.org/oma/group/QSRHNME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q10568", "url": "https://www.orthodb.org/?gene=Q10568", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45922", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45922", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45922:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45922:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13299", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13299", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73856", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77595", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77595", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_787002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q10568-1", "url": "https://www.uniprot.org/uniprotkb/Q10568-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDAEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 782, "header": "sp|Q10568-1|CPSF2_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus OX=9913 GN=CPSF2 PE=1 SV=1 CANONICAL=Q10568-1" }, "isoforms": [ { "isoform_ac": "Q10568-1", "url": "https://www.uniprot.org/uniprotkb/Q10568/entry#Q10568-1", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDAEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 782, "header": "sp|Q10568-1|CPSF2_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus OX=9913 GN=CPSF2 PE=1 SV=1 CANONICAL=Q10568-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 419, "end_pos": 419, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "site_lbl": "Ser419" }, { "start_pos": 420, "end_pos": 420, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "site_lbl": "Ser420" }, { "start_pos": 423, "end_pos": 423, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "site_lbl": "Ser423" }, { "start_pos": 660, "end_pos": 660, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "site_lbl": "Ser660" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit.", "journal": "Mol. Cell. Biol.", "date": "1994", "authors": "Jenny A, Hauri HP, Keller W", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "reference": [ { "type": "PubMed", "id": "7969155", "url": "https://glygen.org/publication/PubMed/7969155" } ] } ], "pathway": [ { "id": "bta:327689", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:327689", "resource": "KEGG Pathway" }, { "id": "R-BTA-159231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "resource": "Reactome", "description": "Transport of Mature mRNA Derived from an Intronless Transcript" }, { "id": "R-BTA-73856", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "resource": "Reactome", "description": "RNA Polymerase II Transcription Termination" }, { "id": "R-BTA-77595", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77595", "resource": "Reactome", "description": "Processing of Intronless Pre-mRNAs" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JTB4-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "Cpsf2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVPGEPDQADNHYWTRKMTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKNKLESGLTNGDEPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDGPSDSSAIAQQKAMKSLFGDDDKELGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 799 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0M5H2-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "Cpsf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSVDIIDSLRKHVHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDVDQPTAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKDSLFRPEDFLVPELQATEEEKSKLESGLTNGEEPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSLFGDDEKELGEESEVIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 787 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NMN0-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "CPSF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDENFSMDIIDSLKKHVHQVDAVLLSHPDPLHLGALPYAVGKMGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHSLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDSKNSIILTYRTTPGTLARFLIDNPSEKVIDIELRRRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDAEEDIDQPTVHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGEEPMDQDLSDVPTKCISATESMEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLVIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELREDEELEMQVDMPSSDSSVIAQQKAMKSLFGDDDKEMCEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNMVAVRRTETGRIGLEGCLCQDFYRIRELLYKQYAIV", "length": 782 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QVV4-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "cpsf2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSIIKLTALSGVQEESALCYLLQVDEFRFLLDCGWDETFSMDIIDSLKRYVHQVDAVLLSHPDHVHLGALPYAVGKLGLNCTIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDSAFDKIQQLKYSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIIYGVDFNHKREIHLNGCSLESLSRPSLLITDSFNASYVQPRRKQRDEQLLTNVMETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHSLSDLARVPSPKVVLCSQPDLESGFSRELFIQWCQDAKNSVILTYRTTPGTLARYLIDNPGEKRIELEIRKRCRLEGRELEEYMEKERMKKEAAKKLEQAKEVDLDSSDESDMEDDLEQPAVVKTKHHDLMMKGEGGRKGGFFKQAKKSYPMFPTHEERIKWDEYGEIIRPEDFLVPELQATEEEKSKLESGLTNGEEPMEQDLSDVPTKCTSTTQTLDIRARVMYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPDASQDLAESCKAYSGKDIKVYIPKLQETVDATSETHIYQVRLKDSLVSSLQFCKARDTELAWIDGVLDMRVEKVDTGVIVELGEAKDEAEEGGEQGMEVTEELNTEPSTAAAANQRAMKTLFGEDEKEISEESDVIPTLEPLPAHEVPGHQSVFINEPRLSDFKQVLLREGIQAEFVGGVLVCNNLVAVRRTEAGRICLEGCHCDDYYRIRELLYEQYAVV", "length": 790 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O35218-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "Cpsf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSVDIIDSLRKHVHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPTEKVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDVDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGEEPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSAMAQQKAMKSLFGEDEKELGEETEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 782 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q12102-1", "protein_name": "Cleavage factor two protein 2", "gene_name": "CFT2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTYKYNCCDDGSGTTVGSVVRFDNVTLLIDPGWNPSKVSYEQCIKYWEKVIPEIDVIILSQPTIECLGAHSLLYYNFTSHFISRIQVYATLPVINLGRVSTIDSYASAGVIGPYDTNKLDLEDIEISFDHIVPLKYSQLVDLRSRYDGLTLLAYNAGVCPGGSIWCISTYSEKLVYAKRWNHTRDNILNAASILDATGKPLSTLMRPSAIITTLDRFGSSQPFKKRSKIFKDTLKKGLSSDGSVIIPVDMSGKFLDLFTQVHELLFESTKINAHTQVPVLILSYARGRTLTYAKSMLEWLSPSLLKTWENRNNTSPFEIGSRIKIIAPNELSKYPGSKICFVSEVGALINEVIIKVGNSEKTTLILTKPSFECASSLDKILEIVEQDERNWKTFPEDGKSFLCDNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKILLVKRESKKLANGNAIIDDTNGERAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNLLKDNSEKSAAKKNTEVPVDIIIQPSAASKHKMFPFNPAKIKKDDYGTVVDFTMFLPDDSDNVNQNSRKRPLKDGAKTTSPVNEEDNKNEEEDGYNMSDPISKRSKHRASRYSGFSGTGEAENFDNLDYLKIDKTLSKRTISTVNVQLKCSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAKLIKKNIEVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISDSYTVATVVGRLVKESLPQVNNHQKTASRSKLVLKPLHGSSRSHKTGALSIGDVRLAQLKKLLTEKNYIAEFKGEGTLVINEKVAVRKINDAETIIDGTPSELFDTVKKLVTDMLAKI", "length": 859 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55BS1-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "cpsf2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MASIIKFTALSGAKDESPPCYLLEIDDFCILLDCGLSYNLDFSLLEPLEKVAKKIDAVLLSHSDTTHIGGLPYVVGKYGLTGTIYGTTPVLKMGTMFLYDLYENKMSQEEFQQYSLDNIDSCFGEDRFKELSFSQHYSLSGKGKGISITPYLAGHTIGASVWKITKGTYSIVYAIDYNHRNEGHLDSLQLTSDILKPSLLITDSKGVDKTLAFKKTITRDQSLFEQINRNLRDGGNVLIPVDTAGRVLELLLCIENYWSKNKSLALYSVVFLGRFSFSVCQFARSQLEFMSSTASVKFEQNIENPFSFKHIKILSSLEELQELPDTNKVILTSSQDLETGFSRELFIQWCSDPKTLILFTQKIPKDSLADKLIKQYSTPNGRGKCIEIVQGSRVPLTGDELLQYEMEQAKQREEKRLEQLRKEQEEREERERLEEEEREQLLNATNQDQLQQLLQLQQQKERGIIDDSMVHMKNPFENDRFDLLDSEFKKQSMITMFPYFEKHLKWGEYGEEDDDLILRNQDKKVEEVTMEEDEIQEQEIPKKIITQTLRLPINCKIQTIDYEGCSDGRSIKAIIQQIAPTKLVLIRGSEQQSQSIENYVKENIRTKGIYIPSIGEQLDLTSDTNVYELLLKDSLVNTLKTSKILDYEVSYIQGKVDILDGSNVPVLDLIQSIPINNNNNNNNNNNNNNNNNNNNTTMMTTTTTTTNGHDESFIGDIKLSDLKQVLVNAGIQVQFDQGILNCGGLVYIWRDEDHGGNSIINVDGIISDEYYLIKELLYKQFQIV", "length": 784 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9LKF9-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "CPSF100", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGTSVQVTPLCGVYNENPLSYLVSIDGFNFLIDCGWNDLFDTSLLEPLSRVASTIDAVLLSHPDTLHIGALPYAMKQLGLSAPVYATEPVHRLGLLTMYDQFLSRKQVSDFDLFTLDDIDSAFQNVIRLTYSQNYHLSGKGEGIVIAPHVAGHMLGGSIWRITKDGEDVIYAVDYNHRKERHLNGTVLQSFVRPAVLITDAYHALYTNQTARQQRDKEFLDTISKHLEVGGNVLLPVDTAGRVLELLLILEQHWSQRGFSFPIYFLTYVSSSTIDYVKSFLEWMSDSISKSFETSRDNAFLLRHVTLLINKTDLDNAPPGPKVVLASMASLEAGFAREIFVEWANDPRNLVLFTETGQFGTLARMLQSAPPPKFVKVTMSKRVPLAGEELIAYEEEQNRLKREEALRASLVKEEETKASHGSDDNSSEPMIIDTKTTHDVIGSHGPAYKDILIDGFVPPSSSVAPMFPYYDNTSEWDDFGEIINPDDYVIKDEDMDRGAMHNGGDVDGRLDEATASLMLDTRPSKVMSNELIVTVSCSLVKMDYEGRSDGRSIKSMIAHVSPLKLVLVHAIAEATEHLKQHCLNNICPHVYAPQIEETVDVTSDLCAYKVQLSEKLMSNVIFKKLGDSEVAWVDSEVGKTERDMRSLLPMPGAASPHKPVLVGDLKIADFKQFLSSKGVQVEFAGGGALRCGEYVTLRKVGPTGQKGGASGPQQILIEGPLCEDYYKIRDYLYSQFYLL", "length": 739 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9P2I0-1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "CPSF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVEAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 782 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3D6-1", "protein_name": "Probable cleavage and polyadenylation specificity factor subunit 2", "gene_name": "Cpsf100", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCEQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAPMDVTVEQDASVQEGKTLTLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAGKVAMEGCLSEEYYKIRELLYEQYAIV", "length": 756 }, "evidence": [ { "id": "Q10568", "url": "https://omabrowser.org/oma/group/Q10568/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA 3'-end processing by stem-loop binding and cleavage", "id": "GO:0006398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006398", "evidence": [ { "database": "UniProtKB", "id": "Q10568", "url": "https://www.uniprot.org/uniprotkb/Q10568" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q10568-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 782, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q10568-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q10568" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 419, 420, 423, 660 ], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 271, "end_pos": 273 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q148C9-1", "uniprot_ac": "Q148C9", "uniprot_id": "HEBP1_BOVIN", "mass": { "chemical_mass": 21230.0, "monoisotopic_mass": 21230.0 }, "refseq": { "ac": "NP_001069453", "name": "heme-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069453" }, "gene_names": [ { "name": "HEBP1", "type": "recommended", "evidence": [ { "id": "Q148C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148C9" } ] }, { "name": "HEBP1", "type": "synonym", "evidence": [ { "id": "NP_001069453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069453" } ] } ], "protein_names": [ { "name": "Heme-binding protein 1", "type": "recommended", "evidence": [ { "id": "Q148C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148C9/entry#names_and_taxonomy" } ] }, { "name": "heme-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069453" } ] } ], "function": [ { "annotation": "May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q148C9", "url": "https://www.uniprot.org/uniprotkb/Q148C9#function" }, { "database": "UniProtKB", "id": "A0AAF6YP18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP18#function" }, { "database": "UniProtKB", "id": "ARBA00037673", "url": "https://www.uniprot.org/uniprotkb/ARBA00037673#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148C9", "url": "https://www.uniprot.org/uniprotkb/Q148C9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEBP1", "url": "https://www.uniprot.org/uniprotkb/Q148C9", "locus": { "chromosome": "5", "start_pos": 96912819, "end_pos": 96875425, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005868", "url": "https://www.ensembl.org/id/ENSBTAG00000005868" } ] } } ], "crossref": [ { "id": "Q148C9", "url": "https://alphafold.ebi.ac.uk/entry/Q148C9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005868", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005868", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533227", "url": "https://www.ncbi.nlm.nih.gov/gene/533227", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533227", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533227", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AYEERTY", "url": "https://omabrowser.org/oma/group/AYEERTY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148C9", "url": "https://www.orthodb.org/?gene=Q148C9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11220:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11220:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069453", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YP18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148C9", "url": "https://www.uniprot.org/uniprotkb/Q148C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148C9-1", "url": "https://www.uniprot.org/uniprotkb/Q148C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGMIKNSLFGSVETWPWQVLSKGSKGDVFYEERACEGGKFATVEVTDKPVDEALREAMPKVMKYVGGSNDKGLGMGMTVPISFAVFPSDDGDLQKKLKVWFRIPNKFQSDPPAPSDDSIKIEDREGITVYSTQFGGYAKAADYAAQAAQLRSALESTAKYQTDFYFCTGYDPPMKPYGRRNEVWLVKSSE", "length": 191, "header": "sp|Q148C9-1|HEBP1_BOVIN Isoform 1 of Heme-binding protein 1 OS=Bos taurus OX=9913 GN=HEBP1 PE=2 SV=1 CANONICAL=Q148C9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YP18-1", "url": "https://www.uniprot.org/uniprotkb/Q148C9/entry#A0AAF6YP18-1", "sequence": { "sequence": "SPYPVFPRASAARRHHVGHDQELAVRERRDLALAGPEQREQDVFYEERACEGGKFATVEVTDKPVDEALREAMPKVMKYVGGSNDKGLGMGMTVPISFAVFPSDDGDLQKKLKVWFRIPNKFQSDPPAPSDDSIKIEDREGITVYSTQFGGYAKAADYAAQAAQLRSALESTAKYQTDFYFCTGYDPPMKPYGRRNEVWLVKSSE", "length": 205, "header": "tr|A0AAF6YP18-1|A0AAF6YP18_BOVIN Computationally mapped isoform of Heme-binding protein 1 OS=Bos taurus OX=9913 GN=HEBP1 PE=1 SV=1 CANONICAL=Q148C9-1" }, "locus": {} }, { "isoform_ac": "Q148C9-1", "url": "https://www.uniprot.org/uniprotkb/Q148C9/entry#Q148C9-1", "sequence": { "sequence": "MLGMIKNSLFGSVETWPWQVLSKGSKGDVFYEERACEGGKFATVEVTDKPVDEALREAMPKVMKYVGGSNDKGLGMGMTVPISFAVFPSDDGDLQKKLKVWFRIPNKFQSDPPAPSDDSIKIEDREGITVYSTQFGGYAKAADYAAQAAQLRSALESTAKYQTDFYFCTGYDPPMKPYGRRNEVWLVKSSE", "length": 191, "header": "sp|Q148C9-1|HEBP1_BOVIN Isoform 1 of Heme-binding protein 1 OS=Bos taurus OX=9913 GN=HEBP1 PE=2 SV=1 CANONICAL=Q148C9-1" }, "locus": { "chromosome": "5", "start_pos": 96912399, "end_pos": 96875474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007711.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007711.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007711.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007711.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533227", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533227", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B4F7C7-1", "protein_name": "Heme-binding protein 1", "gene_name": "Hebp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGMIRNSLFGSVETWPWQVLSTGGKEDVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQGSPPTPSDQSVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKV", "length": 190 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HB42-1", "protein_name": "Heme-binding protein 1", "gene_name": "Hebp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLGMIRNSLFGSVETWPWQVLSTGGKEEVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSSPPVPGDESVKIEEREGITVYSTQFSGYAKEADYIAHATQLRTALEGTTATYQGDLYYCTGYDPPMKPYGRRNEVWLVKT", "length": 190 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ISC6-1", "protein_name": "Heme-binding protein 1", "gene_name": "HEBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGMIKNSLFGSVETWPWQVLSKGDKQDISYEERACEGGKFATVEMTDKPVDEALREAMPKVMKYVGGSNDKGIGMGMTVPISFAVFPSDGGSLQKKLKVWFRIPNEFQSNPPVPSDDSIKIEERESITVYSLQFGGYAKEADYVARAAQLRTALEGIATCRSDVYFCTGYDPPMKPYGRRNEVWLVKA", "length": 189 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5ZMB2-1", "protein_name": "Heme-binding protein 1", "gene_name": "HEBP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLGMIKNSLLSTVETWPYRVLSKGEKEQLSYEERECEGGQFAVVEVTGKPFDEASKEAALKLLKYVGGSNDKGAGMGMTAPVSITAFPAEDGSLQQKVKVYLRIPNQFQASPPCPSDESIKIEERQGMTIYSTQFGGYAKEVDYVNYAAKLKTALGSEAAYRKDFYFCNGYDPPMKPYGRRNEVWFVKE", "length": 189 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9NRV9-1", "protein_name": "Heme-binding protein 1", "gene_name": "HEBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGTATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT", "length": 189 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R257-1", "protein_name": "Heme-binding protein 1", "gene_name": "Hebp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGMIRNSLFGSVETWPWQVLSTGGKEDVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPVSFALFPNEDGSLQKKLKVWFRIPNQFQGSPPAPSDESVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKA", "length": 190 }, "evidence": [ { "id": "Q148C9", "url": "https://omabrowser.org/oma/group/Q148C9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q148C9", "url": "https://www.uniprot.org/uniprotkb/Q148C9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "Q148C9", "url": "https://www.uniprot.org/uniprotkb/Q148C9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148C9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 191, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148C9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148C9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148E0-1", "uniprot_ac": "Q148E0", "uniprot_id": "PXL2C_BOVIN", "mass": { "chemical_mass": 25137.0, "monoisotopic_mass": 25137.0 }, "refseq": { "ac": "NP_001069904", "name": "peroxiredoxin-like 2C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" }, "gene_names": [ { "name": "PRXL2C", "type": "recommended", "evidence": [ { "id": "Q148E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E0" } ] }, { "name": "AAED1", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" }, { "id": "Q148E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E0" } ] }, { "name": "C8H9orf21", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "C9orf21", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "PRXL2C", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] } ], "protein_names": [ { "name": "Peroxiredoxin-like 2C", "type": "recommended", "evidence": [ { "id": "Q148E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E0/entry#names_and_taxonomy" } ] }, { "name": "AhpC/TSA antioxidant enzyme domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "AhpC/TSA antioxidant enzyme domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q148E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E0/entry#names_and_taxonomy" } ] }, { "name": "Thioredoxin-like protein AAED1", "type": "synonym", "evidence": [ { "id": "Q148E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E0/entry#names_and_taxonomy" } ] }, { "name": "UPF0308 protein C9orf21 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "ahpC/TSA antioxidant enzyme domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "peroxiredoxin-like 2C", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] }, { "name": "thioredoxin-like protein AAED1", "type": "synonym", "evidence": [ { "id": "NP_001069904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904" } ] } ], "function": [ { "annotation": "May positively regulate ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.", "evidence": [ { "database": "UniProtKB", "id": "Q148E0", "url": "https://www.uniprot.org/uniprotkb/Q148E0#function" }, { "database": "UniProtKB", "id": "Q7RTV5", "url": "https://www.uniprot.org/uniprotkb/Q7RTV5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148E0", "url": "https://www.uniprot.org/uniprotkb/Q148E0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRXL2C", "url": "https://www.uniprot.org/uniprotkb/Q148E0", "locus": { "chromosome": "8", "start_pos": 83379691, "end_pos": 83396824, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020749", "url": "https://www.ensembl.org/id/ENSBTAG00000020749" } ] } } ], "crossref": [ { "id": "Q148E0", "url": "https://alphafold.ebi.ac.uk/entry/Q148E0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020749", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02970", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02970", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616897", "url": "https://www.ncbi.nlm.nih.gov/gene/616897", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616897", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616897", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MQNTVDH", "url": "https://omabrowser.org/oma/group/MQNTVDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148E0", "url": "https://www.orthodb.org/?gene=Q148E0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28630:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28630:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13911", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13911", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069904", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q148E0", "url": "https://www.uniprot.org/uniprotkb/Q148E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148E0-1", "url": "https://www.uniprot.org/uniprotkb/Q148E0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPSEAPVTRQVSGHAAPAPVPSGPASWQPLAAAVAELPVLDASGRPVLFGELFRERRAIVVFVRHFLCYICKEYVEDLAKIPKSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHVKSNILSGSIRSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHHDRNRLDHKPINSVLQLVGVQHVDFTSRPSVIHV", "length": 228, "header": "sp|Q148E0-1|PXL2C_BOVIN Isoform 1 of Peroxiredoxin-like 2C OS=Bos taurus OX=9913 GN=PRXL2C PE=2 SV=1 CANONICAL=Q148E0-1" }, "isoforms": [ { "isoform_ac": "Q148E0-1", "url": "https://www.uniprot.org/uniprotkb/Q148E0/entry#Q148E0-1", "sequence": { "sequence": "MAAPSEAPVTRQVSGHAAPAPVPSGPASWQPLAAAVAELPVLDASGRPVLFGELFRERRAIVVFVRHFLCYICKEYVEDLAKIPKSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHVKSNILSGSIRSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHHDRNRLDHKPINSVLQLVGVQHVDFTSRPSVIHV", "length": 228, "header": "sp|Q148E0-1|PXL2C_BOVIN Isoform 1 of Peroxiredoxin-like 2C OS=Bos taurus OX=9913 GN=PRXL2C PE=2 SV=1 CANONICAL=Q148E0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616897", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616897", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A506-1", "protein_name": "Peroxiredoxin like 2C", "gene_name": "Prxl2c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPVTRQVSGCAGRVPSPTGSDTERGQPLAAAVAELPVLDASGRRVTFGALFRERRAVVVFVRHFLCYVCKEYVEDLAKIPKSVLQEADVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEISSSGNNIHFVHRDRNRLDHKPINSVLQLVGVQPVNFLSRPAVIHV", "length": 182 }, "evidence": [ { "id": "Q148E0", "url": "https://omabrowser.org/oma/group/Q148E0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NPK3-1", "protein_name": "Peroxiredoxin like 2C", "gene_name": "AAED1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRPPQCPVVQQLRPVSVAPRPELAELREAAYCLVVDADGSRIPFGALYRRQKAIVVFVRNFLCYTCKEYVEDLAKVPRSYLQEANVRLIVIGQSSYHHIKPFCSLTGYTHEMYVDPQREIYKMLGMKRGEGNDVSVQSPHVKSSMLLGSIRSMWRAMTSPAFDFQGDPAQQGGTLILGPGNEVHFLHHDRNRLDHVPINSVLQLAGVKTVNFTNKPQIIDV", "length": 222 }, "evidence": [ { "id": "Q148E0", "url": "https://omabrowser.org/oma/group/Q148E0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7RTV5-1", "protein_name": "Peroxiredoxin-like 2C", "gene_name": "PRXL2C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARGQRVPFGALFRERRAVVVFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV", "length": 226 }, "evidence": [ { "id": "Q148E0", "url": "https://omabrowser.org/oma/group/Q148E0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D1A0-1", "protein_name": "Peroxiredoxin-like 2C", "gene_name": "Prxl2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPVTRQVSGCAGRVPSPAGSVTERGQPLAAAVAELPVLDASGRRVTFGALFRERRAVVVFVRHFLCYVCKEYVEDLAKIPKSVLREADVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEISSSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFVHRDRNRLDHKPINSVLQLVGVQPVNFMSRPTVIHV", "length": 226 }, "evidence": [ { "id": "Q148E0", "url": "https://omabrowser.org/oma/group/Q148E0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "Q148E0", "url": "https://www.uniprot.org/uniprotkb/Q148E0" } ], "pmid": "" }, { "name": "positive regulation of glycolytic process", "id": "GO:0045821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045821", "evidence": [ { "database": "UniProtKB", "id": "Q148E0", "url": "https://www.uniprot.org/uniprotkb/Q148E0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148E0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 228, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148E0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148E0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148E7-1", "uniprot_ac": "Q148E7", "uniprot_id": "SNX15_BOVIN", "mass": { "chemical_mass": 38403.0, "monoisotopic_mass": 38403.0 }, "refseq": { "ac": "NP_001068798", "name": "sorting nexin-15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068798" }, "gene_names": [ { "name": "SNX15", "type": "recommended", "evidence": [ { "id": "Q148E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ] }, { "name": "SNX15", "type": "synonym", "evidence": [ { "id": "NP_001068798", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068798" } ] } ], "protein_names": [ { "name": "Sorting nexin-15", "type": "recommended", "evidence": [ { "id": "Q148E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#names_and_taxonomy" } ] }, { "name": "sorting nexin-15", "type": "synonym", "evidence": [ { "id": "NP_001068798", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068798" } ] } ], "function": [ { "annotation": "May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7#function" }, { "database": "UniProtKB", "id": "A0AAA9RW73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW73#function" }, { "database": "UniProtKB", "id": "ARBA00053809", "url": "https://www.uniprot.org/uniprotkb/ARBA00053809#function" }, { "database": "UniProtKB", "id": "A0AAA9SY62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY62#function" }, { "database": "UniProtKB", "id": "A0AAA9SYI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYI5#function" }, { "database": "UniProtKB", "id": "A0AAF6YJC4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX15", "url": "https://www.uniprot.org/uniprotkb/Q148E7", "locus": { "chromosome": "29", "start_pos": 43254072, "end_pos": 43235199, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002243", "url": "https://www.ensembl.org/id/ENSBTAG00000002243" } ] } } ], "crossref": [ { "id": "Q148E7", "url": "https://alphafold.ebi.ac.uk/entry/Q148E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002243", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002243", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02677", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02677", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07288", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07288", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507751", "url": "https://www.ncbi.nlm.nih.gov/gene/507751", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507751", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507751", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EMLVDQH", "url": "https://omabrowser.org/oma/group/EMLVDQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M945", "url": "https://www.orthodb.org/?gene=A0A3Q1M945", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMH8", "url": "https://www.orthodb.org/?gene=A0A3Q1MMH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q148E7", "url": "https://www.orthodb.org/?gene=Q148E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15508:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15508:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068798", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M945", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M945", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M945-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M945-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJC4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148E7-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 345, "header": "sp|Q148E7-1|SNX15_BOVIN Isoform 1 of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=2 SV=1 CANONICAL=Q148E7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M945-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0A3Q1M945-1", "sequence": { "sequence": "LGLQSLGFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 319, "header": "tr|A0A3Q1M945-1|A0A3Q1M945_BOVIN Computationally mapped isoform of Sorting nexin 15 OS=Bos taurus OX=9913 GN=SNX15 PE=4 SV=2 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253608, "end_pos": 43243039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084085.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084085.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066647.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066647.2" } ] } }, { "isoform_ac": "A0A3Q1MMH8-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0A3Q1MMH8-1", "sequence": { "sequence": "VEVFRPEEGKDSLLEQLLPSEAKDDFLRHYTVSDPRTHPKGYTEYKVTAQVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 350, "header": "tr|A0A3Q1MMH8-1|A0A3Q1MMH8_BOVIN Computationally mapped isoform of Sorting nexin 15 OS=Bos taurus OX=9913 GN=SNX15 PE=4 SV=2 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253608, "end_pos": 43235271, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082773.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082773.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072355.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072355.2" } ] } }, { "isoform_ac": "A0AAA9RW73-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0AAA9RW73-1", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLSLPPR", "length": 342, "header": "tr|A0AAA9RW73-1|A0AAA9RW73_BOVIN Computationally mapped isoform of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=3 SV=1 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253623, "end_pos": 43242613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088810.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088810.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076627.1" } ] } }, { "isoform_ac": "A0AAA9SY62-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0AAA9SY62-1", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEGDPSPARREGVKKKAAEYLKRAEEILHLHLSLPPR", "length": 256, "header": "tr|A0AAA9SY62-1|A0AAA9SY62_BOVIN Computationally mapped isoform of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=3 SV=1 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253623, "end_pos": 43242613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097106.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097106.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088259.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088259.1" } ] } }, { "isoform_ac": "A0AAA9SYI5-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0AAA9SYI5-1", "sequence": { "sequence": "GKEFKQIQCEFRHPLIWAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 358, "header": "tr|A0AAA9SYI5-1|A0AAA9SYI5_BOVIN Computationally mapped isoform of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=3 SV=1 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253608, "end_pos": 43236025, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107534.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107534.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089312.1" } ] } }, { "isoform_ac": "A0AAF6YJC4-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#A0AAF6YJC4-1", "sequence": { "sequence": "MDCSLPGSSAHGIFQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 356, "header": "tr|A0AAF6YJC4-1|A0AAF6YJC4_BOVIN Computationally mapped isoform of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=3 SV=1 CANONICAL=Q148E7-1" }, "locus": { "chromosome": "29", "start_pos": 43253608, "end_pos": 43242278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002897.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002897.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002897.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002897.4" } ] } }, { "isoform_ac": "Q148E7-1", "url": "https://www.uniprot.org/uniprotkb/Q148E7/entry#Q148E7-1", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS", "length": 345, "header": "sp|Q148E7-1|SNX15_BOVIN Isoform 1 of Sorting nexin-15 OS=Bos taurus OX=9913 GN=SNX15 PE=2 SV=1 CANONICAL=Q148E7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 208, "end_pos": 208, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "site_lbl": "Ser208" }, { "start_pos": 234, "end_pos": 234, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "site_lbl": "Ser234" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507751", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507751", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BP98-1", "protein_name": "Sorting nexin-15", "gene_name": "SNX15", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSETSRDLHILPPPLIPTPPPDEPRLPQPLPAERRGLEELEGPVDPPPSSPAQEALDLLFNCGSTEDTSGSPARGPLTEAELALFDPFSKEEGAGPSPTHLGELAALEAESERLDQEPWEPGGQEEEEDEEGGPTPAYLNQATKLITQALRDERAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLSQLPP", "length": 342 }, "evidence": [ { "id": "Q148E7", "url": "https://omabrowser.org/oma/group/Q148E7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q91WE1-1", "protein_name": "Sorting nexin-15", "gene_name": "Snx15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDIKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVPIPALNNSPQLKEFFRGGEVTRPSEVSRDLRILPPPLIPTPPPDEARLLQPLPAERRGQEELEVPVDPLPSSPAQEALDLLFSCDSTEEASSSLARGPLSEAELALFDPYSKEESTGPSPTHTGELAAIEVESKRLDQEPWEPGGQEEEEAEDGEPAPAYLGQATELITQALRNEKAGAYAAALQGYQDGVHILLQGVSGDPSPARREGVKKKAAEYLKRAEMLHTHLP", "length": 337 }, "evidence": [ { "id": "Q148E7", "url": "https://omabrowser.org/oma/group/Q148E7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRS6-1", "protein_name": "Sorting nexin-15", "gene_name": "SNX15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP", "length": 342 }, "evidence": [ { "id": "Q148E7", "url": "https://omabrowser.org/oma/group/Q148E7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q148E7", "url": "https://www.uniprot.org/uniprotkb/Q148E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148E7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148E7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148E7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q148E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148E7" }, { "id": "PRU00147", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00147" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 130, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 208, 234 ], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148G4-1", "uniprot_ac": "Q148G4", "uniprot_id": "TATD1_BOVIN", "mass": { "chemical_mass": 33886.0, "monoisotopic_mass": 33886.0 }, "refseq": { "ac": "NP_001068870", "name": "deoxyribonuclease TATDN1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870" }, "gene_names": [ { "name": "TATDN1", "type": "recommended", "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ] }, { "name": "TATDN1", "type": "synonym", "evidence": [ { "id": "NP_001068870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870" } ] } ], "protein_names": [ { "name": "Deoxyribonuclease TATDN1", "type": "recommended", "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4/entry#names_and_taxonomy" } ] }, { "name": "3.1.11.-", "type": "synonym", "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4/entry#names_and_taxonomy" } ] }, { "name": "3.1.21.-", "type": "synonym", "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4/entry#names_and_taxonomy" } ] }, { "name": "DNA-(apurinic or apyrimidinic site) endonuclease TATDN1", "type": "synonym", "evidence": [ { "id": "NP_001068870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870" }, { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4/entry#names_and_taxonomy" } ] }, { "name": "deoxyribonuclease TATDN1", "type": "synonym", "evidence": [ { "id": "NP_001068870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870" } ] }, { "name": "putative deoxyribonuclease TATDN1", "type": "synonym", "evidence": [ { "id": "NP_001068870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870" } ] } ], "function": [ { "annotation": "Exhibits 3'-5' exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro). Shows preferential AP endonuclease activity on dsDNA substrates and 3'-5'exonuclease activity on ssDNA (By similarity). Catalyzes decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4#function" }, { "database": "UniProtKB", "id": "Q6GML7", "url": "https://www.uniprot.org/uniprotkb/Q6GML7#function" }, { "database": "UniProtKB", "id": "Q6P1N9", "url": "https://www.uniprot.org/uniprotkb/Q6P1N9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TATDN1", "url": "https://www.uniprot.org/uniprotkb/Q148G4", "locus": { "chromosome": "14", "start_pos": 15592470, "end_pos": 15560824, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033446", "url": "https://www.ensembl.org/id/ENSBTAG00000033446" } ] } } ], "crossref": [ { "id": "Q148G4", "url": "https://alphafold.ebi.ac.uk/entry/Q148G4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033446", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01310", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01310", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509365", "url": "https://www.ncbi.nlm.nih.gov/gene/509365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGGSQKH", "url": "https://omabrowser.org/oma/group/YGGSQKH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148G4", "url": "https://www.orthodb.org/?gene=Q148G4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10060:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10060:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068870", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148G4-1", "url": "https://www.uniprot.org/uniprotkb/Q148G4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAVQIGVKKFMITGGNLQDSKDALHLAQTNDMFFSTVGCHPTRCDEFEKNDPDHYLMELLNLAESNKGKVVAIGECGLDFDRLQFCSKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALMDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKNTHAGSKYIKTSFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKIFFPDM", "length": 297, "header": "sp|Q148G4-1|TATD1_BOVIN Isoform 1 of Deoxyribonuclease TATDN1 OS=Bos taurus OX=9913 GN=TATDN1 PE=2 SV=1 CANONICAL=Q148G4-1" }, "isoforms": [ { "isoform_ac": "Q148G4-1", "url": "https://www.uniprot.org/uniprotkb/Q148G4/entry#Q148G4-1", "sequence": { "sequence": "MSRFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAVQIGVKKFMITGGNLQDSKDALHLAQTNDMFFSTVGCHPTRCDEFEKNDPDHYLMELLNLAESNKGKVVAIGECGLDFDRLQFCSKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALMDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKNTHAGSKYIKTSFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKIFFPDM", "length": 297, "header": "sp|Q148G4-1|TATD1_BOVIN Isoform 1 of Deoxyribonuclease TATDN1 OS=Bos taurus OX=9913 GN=TATDN1 PE=2 SV=1 CANONICAL=Q148G4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509365", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AHP3-1", "protein_name": "Deoxyribonuclease TATDN1", "gene_name": "Tatdn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQYLAGLLHLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIKTAFPTKKKWEAGCCLKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIFFS", "length": 295 }, "evidence": [ { "id": "Q148G4", "url": "https://omabrowser.org/oma/group/Q148G4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y0W3-1", "protein_name": "Deoxyribonuclease TATDN1", "gene_name": "TATDN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFRGIYRGTRKHQDDLLDVVERAVAVGVKKFLITGGSLQDSKDALQLAQTNDMFYSTAGCHPTRCGEFEQSNPDQYLSELKSLIEKNKTKVIAVGECGLDFDRLEFCPKDIQLKYFEKQFDLAEQTRLPMFLHCRNSHAEFLDIMRRNRERFVGGVVHSFDGTKEEAAAIIDLELYIGINGCSLKTEANLEALKSIPSERLMIETDAPWCGVKSTHAGSKYVKTTFPTKKKWEMGHCLKDRNEPCHIIVSSFFCNLYRILIRWHKPIVVRDVGVLLVLNIYFLMAHGAGVLNVQPLPKTKCMKVMVAWGNASRCGELMIADCTYVIYFTEPASFHLWKGVYFLNSSPAIYKSLPAILCLQIDVEVRMQTHHARADLTSRFKNHCVGSISKHDDSKYKLNNIASGANIIDVIVQFFPQHVVVAIDHKQYINSDRNDYFQAELYTERSNCEKPRVQCIVVPEDVTEQNRQDEKAS", "length": 473 }, "evidence": [ { "id": "Q148G4", "url": "https://omabrowser.org/oma/group/Q148G4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54SD3-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKFIDIGVNLTDPMFIGQYNNNGKQYHEADLKQVLERAWSIGMEKIIITSGRLSEVKESLELIKTYSEENNNNNKNRLFTTIGVHPTRCSQELINTTNGNDEIKKEYIEELLTIYNENKEKIIAIGEFGLDYDRLEFCSKEIQLKCFEYQFQLSERTELPLFLHLRGAAESGACSDFIDIIKRNRSRFTVGVVHSFTGTLDELNKLLELDDGIYIGVNGCSLKTQENLDVVSKIPINRLMIETDAPWCDIRKTHSSFKYIKTNFPTLKRDKFKLGSCVQNRNEPCNIINVLEVISGLNGGNMEEISDQIYKNTIKVFFPDLENK", "length": 324 }, "evidence": [ { "id": "Q148G4", "url": "https://omabrowser.org/oma/group/Q148G4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P1N9-1", "protein_name": "Deoxyribonuclease TATDN1", "gene_name": "TATDN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI", "length": 297 }, "evidence": [ { "id": "Q148G4", "url": "https://omabrowser.org/oma/group/Q148G4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P8M1-1", "protein_name": "Deoxyribonuclease TATDN1", "gene_name": "Tatdn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAIQIGVKKFMITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQYLAGLLSLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYINTSFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVREEDPLELANTLYNNTIKVFFS", "length": 295 }, "evidence": [ { "id": "Q148G4", "url": "https://omabrowser.org/oma/group/Q148G4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "3'-5'-DNA exonuclease activity", "id": "GO:0008296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008296", "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "pmid": "" }, { "name": "DNA endonuclease activity", "id": "GO:0004520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004520", "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q148G4", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148G4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148G4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148G4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4#function" }, { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "binding_site_uniprot": 112, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 112, "end_pos": 112, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4#function" }, { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "binding_site_uniprot": 149, "amino_acid": "His", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 149, "end_pos": 149, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4#function" }, { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "binding_site_uniprot": 174, "amino_acid": "His", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 174, "end_pos": 174, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4#function" }, { "id": "Q148G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148G4" } ], "binding_site_uniprot": 222, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 222, "end_pos": 222, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 287, "end_pos": 289 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148H4-1", "uniprot_ac": "Q148H4", "uniprot_id": "KRT81_BOVIN", "mass": { "chemical_mass": 54613.0, "monoisotopic_mass": 54613.0 }, "refseq": { "ac": "NP_001069674", "name": "keratin, type II cuticular Hb1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" }, "gene_names": [ { "name": "KRT81", "type": "recommended", "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ] }, { "name": "KRT81", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" } ] } ], "protein_names": [ { "name": "Keratin, type II cuticular Hb1", "type": "recommended", "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#names_and_taxonomy" } ] }, { "name": "K81", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" }, { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#names_and_taxonomy" } ] }, { "name": "Keratin-81", "type": "synonym", "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#names_and_taxonomy" } ] }, { "name": "Type II hair keratin Hb1", "type": "synonym", "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#names_and_taxonomy" } ] }, { "name": "Type-II keratin Kb21", "type": "synonym", "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#names_and_taxonomy" } ] }, { "name": "hair type II keratin intermediate filament protein", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" } ] }, { "name": "keratin, type II cuticular Hb1", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" } ] }, { "name": "type II hair keratin Hb1", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" } ] }, { "name": "type-II keratin Kb21", "type": "synonym", "evidence": [ { "id": "NP_001069674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674" } ] } ], "function": [ { "annotation": "Structural component of intermediate filaments in the hair cortex. Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft.", "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4#function" }, { "database": "UniProtKB", "id": "Q14533", "url": "https://www.uniprot.org/uniprotkb/Q14533#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT81", "url": "https://www.uniprot.org/uniprotkb/Q148H4", "locus": { "chromosome": "5", "start_pos": 27606658, "end_pos": 27601187, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006739", "url": "https://www.ensembl.org/id/ENSBTAG00000006739" } ] } } ], "crossref": [ { "id": "Q148H4", "url": "https://alphafold.ebi.ac.uk/entry/Q148H4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006739", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006739", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540204", "url": "https://www.ncbi.nlm.nih.gov/gene/540204", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540204", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540204", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCESHLE", "url": "https://omabrowser.org/oma/group/CCESHLE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148H4", "url": "https://www.orthodb.org/?gene=Q148H4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069674", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148H4-1", "url": "https://www.uniprot.org/uniprotkb/Q148H4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCGSGFRGRAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSICGGFRAGSFGRSFGYRSGGVGGLNPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFNGYIETLRREAECVEADSGRLSSELNSLQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAQYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRVIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCSGNLAVSTGLCAPCGPCNSVTSCGLGGISSCGVGSCASVCRKC", "length": 500, "header": "sp|Q148H4-1|KRT81_BOVIN Isoform 1 of Keratin, type II cuticular Hb1 OS=Bos taurus OX=9913 GN=KRT81 PE=2 SV=1 CANONICAL=Q148H4-1" }, "isoforms": [ { "isoform_ac": "Q148H4-1", "url": "https://www.uniprot.org/uniprotkb/Q148H4/entry#Q148H4-1", "sequence": { "sequence": "MTCGSGFRGRAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSICGGFRAGSFGRSFGYRSGGVGGLNPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFNGYIETLRREAECVEADSGRLSSELNSLQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAQYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRVIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCSGNLAVSTGLCAPCGPCNSVTSCGLGGISSCGVGSCASVCRKC", "length": 500, "header": "sp|Q148H4-1|KRT81_BOVIN Isoform 1 of Keratin, type II cuticular Hb1 OS=Bos taurus OX=9913 GN=KRT81 PE=2 SV=1 CANONICAL=Q148H4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540204", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540204", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "O43790-1", "protein_name": "Keratin, type II cuticular Hb6", "gene_name": "KRT86", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGVCGGSCKRC", "length": 486 }, "evidence": [ { "id": "Q148H4", "url": "https://omabrowser.org/oma/group/Q148H4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ERE2-1", "protein_name": "Keratin, type II cuticular Hb1", "gene_name": "Krt81", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTCGSGFCGRAFSCASACGPRPGRCCISAAPYRGISCYRGLSGGFGSQSVCGAFRSGSCGRSFGYRSGGICGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKHEEKEQIKCLNSKFAAFIDKVRFLEQQNKLLETKWQFYQNRKCCESNMEPLFEGYIEALRREAECVEADSGRLAAELNHAQESMEGYKKRYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANAEALTQETDFLRRMYDEETRILHSHISDTSIVVKMDNSRDLNMDCVVAEIKAQYDDIASRSRAEAESWYRTKCEEIKATVIRHGETLRRTREEINELNRMIQRLTAEIENAKCQNTKLEAAVTQSEQQGEAALADARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDVEITTYRRLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCVSGSRPVIGSACSAPCSGNLAVNTGLCAPCGSAVSCGRKC", "length": 481 }, "evidence": [ { "id": "Q148H4", "url": "https://omabrowser.org/oma/group/Q148H4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "Q148H4", "url": "https://www.uniprot.org/uniprotkb/Q148H4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148H4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 500, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148H4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148H4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q148H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148H4" }, { "id": "PRU01188", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000255", "start_pos": 106, "end_pos": 417, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148I3-1", "uniprot_ac": "Q148I3", "uniprot_id": "KISHA_BOVIN", "mass": { "chemical_mass": 8060.0, "monoisotopic_mass": 8060.0 }, "refseq": { "ac": "NP_001107983", "name": "protein kish-A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" }, "gene_names": [ { "name": "TMEM167A", "type": "recommended", "evidence": [ { "id": "Q148I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I3" } ] }, { "name": "TMEM167A", "type": "synonym", "evidence": [ { "id": "NP_001107983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" } ] }, { "name": "TMEM167", "type": "synonym", "evidence": [ { "id": "NP_001107983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" } ] } ], "protein_names": [ { "name": "Protein kish-A", "type": "recommended", "evidence": [ { "id": "Q148I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I3/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 167A", "type": "synonym", "evidence": [ { "id": "Q148I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I3/entry#names_and_taxonomy" } ] }, { "name": "protein kish-A precursor", "type": "synonym", "evidence": [ { "id": "NP_001107983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" } ] }, { "name": "protein kish-A", "type": "synonym", "evidence": [ { "id": "NP_001107983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" } ] }, { "name": "transmembrane protein 167", "type": "synonym", "evidence": [ { "id": "NP_001107983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983" } ] } ], "function": [ { "annotation": "Involved in the early part of the secretory pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q148I3", "url": "https://www.uniprot.org/uniprotkb/Q148I3#function" }, { "database": "UniProtKB", "id": "A0AAF6ZLE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE7#function" }, { "database": "UniProtKB", "id": "ARBA00002154", "url": "https://www.uniprot.org/uniprotkb/ARBA00002154#function" }, { "database": "UniProtKB", "id": "RU910717", "url": "https://www.uniprot.org/uniprotkb/RU910717#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148I3", "url": "https://www.uniprot.org/uniprotkb/Q148I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM167A", "url": "https://www.uniprot.org/uniprotkb/Q148I3", "locus": { "chromosome": "7", "start_pos": 82914069, "end_pos": 82958909, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039591", "url": "https://www.ensembl.org/id/ENSBTAG00000039591" } ] } } ], "crossref": [ { "id": "Q148I3", "url": "https://alphafold.ebi.ac.uk/entry/Q148I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039591", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039591", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613669", "url": "https://www.ncbi.nlm.nih.gov/gene/613669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613669", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613669", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KVGFQGT", "url": "https://omabrowser.org/oma/group/KVGFQGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148I3", "url": "https://www.orthodb.org/?gene=Q148I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06842", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06842", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001107983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107983", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZLE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZLE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148I3", "url": "https://www.uniprot.org/uniprotkb/Q148I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148I3-1", "url": "https://www.uniprot.org/uniprotkb/Q148I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ", "length": 72, "header": "sp|Q148I3-1|KISHA_BOVIN Isoform 1 of Protein kish-A OS=Bos taurus OX=9913 GN=TMEM167A PE=3 SV=1 CANONICAL=Q148I3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZLE7-1", "url": "https://www.uniprot.org/uniprotkb/Q148I3/entry#A0AAF6ZLE7-1", "sequence": { "sequence": "MWLGLRRPHYGKNRGFGVATESAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ", "length": 92, "header": "tr|A0AAF6ZLE7-1|A0AAF6ZLE7_BOVIN Computationally mapped isoform of Protein kish OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q148I3-1" }, "locus": {} }, { "isoform_ac": "Q148I3-1", "url": "https://www.uniprot.org/uniprotkb/Q148I3/entry#Q148I3-1", "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ", "length": 72, "header": "sp|Q148I3-1|KISHA_BOVIN Isoform 1 of Protein kish-A OS=Bos taurus OX=9913 GN=TMEM167A PE=3 SV=1 CANONICAL=Q148I3-1" }, "locus": { "chromosome": "7", "start_pos": 82958682, "end_pos": 82915347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055060.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055060.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053007.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053007.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 35, "start_aa": "Asn", "end_pos": 35, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn35", "evidence": [ { "id": "Q148I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:613669", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613669", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FGN0-1", "protein_name": "Protein kish", "gene_name": "TMEM167A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCVVMAFSILFIQ", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HIY0-1", "protein_name": "Protein kish", "gene_name": "Tmem167a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54HH9-1", "protein_name": "Protein kish", "gene_name": "tmem167", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVAIFNFQSLLVVILLFICTCTYIRGSYPSLLEVRDKHSFSGLPRKAAIIGERLSPWVSACCLIMGLWTLYN", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8TBQ9-1", "protein_name": "Protein kish-A", "gene_name": "TMEM167A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8TGJ3-1", "protein_name": "Protein Kish", "gene_name": "KSH1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSALFNFRSLLQVILLLICSCSYVHGQWPSLLDRYKNHEVLGAFWKMARVGERASPYVSLACILMAISQFNS", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CR64-1", "protein_name": "Protein kish-A", "gene_name": "Tmem167a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAIFNFQSLLTVILLLICTCAYIRSLAPSILDRNKTGLLGIFWKCARIGERKSPYVAICCIVMAFSILFIQ", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VWH8-1", "protein_name": "Protein kish", "gene_name": "ksh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSALFNFHSLLSVILLLICTCAYLRSLFPSLIDRNKTGFMGTFWKLARIGERKSPWVGAACLIMAFTVLFWS", "length": 72 }, "evidence": [ { "id": "Q148I3", "url": "https://omabrowser.org/oma/group/Q148I3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q148I3", "url": "https://www.uniprot.org/uniprotkb/Q148I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q148I3", "url": "https://www.uniprot.org/uniprotkb/Q148I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148I3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 72, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148I3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148I3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 35 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148I5-1", "uniprot_ac": "Q148I5", "uniprot_id": "KTI12_BOVIN", "mass": { "chemical_mass": 38782.0, "monoisotopic_mass": 38782.0 }, "refseq": { "ac": "NP_001074206", "name": "protein KTI12 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074206" }, "gene_names": [ { "name": "KTI12", "type": "recommended", "evidence": [ { "id": "Q148I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I5" } ] }, { "name": "KTI12", "type": "synonym", "evidence": [ { "id": "NP_001074206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074206" } ] } ], "protein_names": [ { "name": "Protein KTI12 homolog", "type": "recommended", "evidence": [ { "id": "Q148I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148I5/entry#names_and_taxonomy" } ] }, { "name": "KTI12 homolog, chromatin associated", "type": "synonym", "evidence": [ { "id": "NP_001074206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074206" } ] }, { "name": "protein KTI12 homolog", "type": "synonym", "evidence": [ { "id": "NP_001074206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074206" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148I5", "url": "https://www.uniprot.org/uniprotkb/Q148I5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KTI12", "url": "https://www.uniprot.org/uniprotkb/Q148I5", "locus": {} } ], "crossref": [ { "id": "Q148I5", "url": "https://alphafold.ebi.ac.uk/entry/Q148I5", "database": "AlphaFoldDB", "categories": [] }, { "id": "538901", "url": "https://www.ncbi.nlm.nih.gov/gene/538901", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538901", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538901", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q148I5", "url": "https://www.orthodb.org/?gene=Q148I5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12435", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12435", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47027:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47027:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08433", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08433", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001074206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074206", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148I5", "url": "https://www.uniprot.org/uniprotkb/Q148I5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148I5-1", "url": "https://www.uniprot.org/uniprotkb/Q148I5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLVVFCGLPYSGKSRRVEELRAALEAEGRAVQVVDDAAVLGAEDATVYGDSAREKALRGALRAAVERLLSRQDVVILDSLNYIKGFRYELYCLARAARTPICLVYCVRPGSLSGGLRVAGAVDNPNRNVSVSWRPRAEEGGRPLAVGTDVLGEPQAVASLVNRRAQAEVPTESEPKEIRAADLPALVASESEKSAEHASGAFYPPELLEALALRFEAPDSRNRWDRPLFTLVGLEEPLPLAEIRAALFENRAPPPHQSTQSQPLASGSFLHQLDQVTSQVLAGLMEAQKSAVPGDLLKLPGTTEHLRFTRPLTMAELSRLRRQFISYTKMHTNNENLPQLANMFLQYLSQSLH", "length": 354, "header": "sp|Q148I5-1|KTI12_BOVIN Isoform 1 of Protein KTI12 homolog OS=Bos taurus OX=9913 GN=KTI12 PE=2 SV=1 CANONICAL=Q148I5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFN2-1", "url": "https://www.uniprot.org/uniprotkb/Q148I5/entry#A0AAA9TFN2-1", "sequence": { "sequence": "MQNAGLDEAQTGIKTAGRNINNLTYADDTTLMAESEEELKSLLMEVKESEKVGFKLNIQKTKIMASGPITSWQTDRETMETVNDFILGGSKITGYGDCSHEIKRLLLLGRKAITKLDSTLKSRDITLPTKVHLVKAMVFPVVMYGCESWTIKKAER", "length": 156, "header": "tr|A0AAA9TFN2-1|A0AAA9TFN2_BOVIN Computationally mapped isoform of Reverse transcriptase domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=Q148I5-1" }, "locus": { "chromosome": "3", "start_pos": 94302246, "end_pos": 94301185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119808.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119808.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096965.1" } ] } }, { "isoform_ac": "Q148I5-1", "url": "https://www.uniprot.org/uniprotkb/Q148I5/entry#Q148I5-1", "sequence": { "sequence": "MPLVVFCGLPYSGKSRRVEELRAALEAEGRAVQVVDDAAVLGAEDATVYGDSAREKALRGALRAAVERLLSRQDVVILDSLNYIKGFRYELYCLARAARTPICLVYCVRPGSLSGGLRVAGAVDNPNRNVSVSWRPRAEEGGRPLAVGTDVLGEPQAVASLVNRRAQAEVPTESEPKEIRAADLPALVASESEKSAEHASGAFYPPELLEALALRFEAPDSRNRWDRPLFTLVGLEEPLPLAEIRAALFENRAPPPHQSTQSQPLASGSFLHQLDQVTSQVLAGLMEAQKSAVPGDLLKLPGTTEHLRFTRPLTMAELSRLRRQFISYTKMHTNNENLPQLANMFLQYLSQSLH", "length": 354, "header": "sp|Q148I5-1|KTI12_BOVIN Isoform 1 of Protein KTI12 homolog OS=Bos taurus OX=9913 GN=KTI12 PE=2 SV=1 CANONICAL=Q148I5-1" }, "locus": { "chromosome": "3", "start_pos": 94302246, "end_pos": 94301185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152035.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152035.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105378.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q148I5", "url": "https://www.uniprot.org/uniprotkb/Q148I5" } ], "site_lbl": "Ser200" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538901", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538901", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q148I5", "url": "https://www.uniprot.org/uniprotkb/Q148I5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "Q148I5", "url": "https://www.uniprot.org/uniprotkb/Q148I5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148I5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148I5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148I5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 200 ], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148L7-1", "uniprot_ac": "Q148L7", "uniprot_id": "PDRG1_BOVIN", "mass": { "chemical_mass": 15610.0, "monoisotopic_mass": 15610.0 }, "refseq": { "ac": "NP_001071583", "name": "p53 and DNA damage-regulated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071583" }, "gene_names": [ { "name": "PDRG1", "type": "recommended", "evidence": [ { "id": "Q148L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ] }, { "name": "PDRG1", "type": "synonym", "evidence": [ { "id": "NP_001071583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071583" } ] } ], "protein_names": [ { "name": "p53 and DNA damage-regulated protein 1", "type": "recommended", "evidence": [ { "id": "Q148L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148L7/entry#names_and_taxonomy" } ] }, { "name": "p53 and DNA damage-regulated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001071583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071583" } ] } ], "function": [ { "annotation": "May play a role in chaperone-mediated protein folding.", "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDRG1", "url": "https://www.uniprot.org/uniprotkb/Q148L7", "locus": { "chromosome": "13", "start_pos": 61464644, "end_pos": 61471874, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009743", "url": "https://www.ensembl.org/id/ENSBTAG00000009743" } ] } } ], "crossref": [ { "id": "Q148L7", "url": "https://alphafold.ebi.ac.uk/entry/Q148L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009743", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22860", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22860", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768241", "url": "https://www.ncbi.nlm.nih.gov/gene/768241", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768241", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768241", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEKAMVC", "url": "https://omabrowser.org/oma/group/DEKAMVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q148L7", "url": "https://www.orthodb.org/?gene=Q148L7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21162:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21162:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071583", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148L7-1", "url": "https://www.uniprot.org/uniprotkb/Q148L7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNRNREGLRALQKDLSLTEDVMVCFGNMFIRMPHPETKEMIEKDQEHLDKEIERLRKQLKVKVNRLFEAQGKPELKGFNLTPLNQDELKALKVILKG", "length": 133, "header": "sp|Q148L7-1|PDRG1_BOVIN Isoform 1 of p53 and DNA damage-regulated protein 1 OS=Bos taurus OX=9913 GN=PDRG1 PE=2 SV=1 CANONICAL=Q148L7-1" }, "isoforms": [ { "isoform_ac": "Q148L7-1", "url": "https://www.uniprot.org/uniprotkb/Q148L7/entry#Q148L7-1", "sequence": { "sequence": "MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNRNREGLRALQKDLSLTEDVMVCFGNMFIRMPHPETKEMIEKDQEHLDKEIERLRKQLKVKVNRLFEAQGKPELKGFNLTPLNQDELKALKVILKG", "length": 133, "header": "sp|Q148L7-1|PDRG1_BOVIN Isoform 1 of p53 and DNA damage-regulated protein 1 OS=Bos taurus OX=9913 GN=PDRG1 PE=2 SV=1 CANONICAL=Q148L7-1" }, "locus": { "chromosome": "13", "start_pos": 61471832, "end_pos": 61466197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012845.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012845.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012845.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012845.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768241", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768241", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0XDX9-1", "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "PDRG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNRNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLNKEIERLRKQLKVKVNRLFEAQGKPELKGFNLSPLNQDELKALKIILKG", "length": 133 }, "evidence": [ { "id": "Q148L7", "url": "https://omabrowser.org/oma/group/Q148L7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YZF4-1", "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "PDRG1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARDPAFVLRYLAEVEELAEDVLAARQQIVDLDVKRNRNREALRALHKDPEPGGKAMVCFGSTFVELPKAKTEEMLQKDQEHLDEEINNLRKELRVKVNRLFEAQGKPELKGFNLNPMTAEEMKLINRILEG", "length": 132 }, "evidence": [ { "id": "Q148L7", "url": "https://omabrowser.org/oma/group/Q148L7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HEA1-1", "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "Pdrg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSPEAERVMRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDLSVSEDVMVCFGNMFIKMPHPKTKEMIQKDQEHLDKEIERLRNQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG", "length": 133 }, "evidence": [ { "id": "Q148L7", "url": "https://omabrowser.org/oma/group/Q148L7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P59048-1", "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "Pdrg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSPEAERVLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDLSVSEDVMVCFGNMFIKMPHPKTKEMIQKDQEHLDKEIERLRSQLKVKVNRLFEAQGKPELKGFNLNPLSPDEVKALKVILKG", "length": 133 }, "evidence": [ { "id": "Q148L7", "url": "https://omabrowser.org/oma/group/Q148L7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NUG6-1", "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "PDRG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG", "length": 133 }, "evidence": [ { "id": "Q148L7", "url": "https://omabrowser.org/oma/group/Q148L7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q148L7", "url": "https://www.uniprot.org/uniprotkb/Q148L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148L7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 133, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148L7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148L7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q148M7-1", "uniprot_ac": "Q148M7", "uniprot_id": "TAF13_BOVIN", "mass": { "chemical_mass": 14287.0, "monoisotopic_mass": 14287.0 }, "refseq": { "ac": "NP_001069065", "name": "transcription initiation factor TFIID subunit 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" }, "gene_names": [ { "name": "TAF13", "type": "recommended", "evidence": [ { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ] }, { "name": "TAF13", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" } ] } ], "protein_names": [ { "name": "Transcription initiation factor TFIID subunit 13", "type": "recommended", "evidence": [ { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#names_and_taxonomy" } ] }, { "name": "TAF(II)18", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" }, { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#names_and_taxonomy" } ] }, { "name": "TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" } ] }, { "name": "TAFII-18", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" }, { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#names_and_taxonomy" } ] }, { "name": "TAFII18", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" }, { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#names_and_taxonomy" } ] }, { "name": "TATA box-binding protein-associated factor, RNA polymerase II, K, 18kD", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" } ] }, { "name": "Transcription initiation factor TFIID 18 kDa subunit", "type": "synonym", "evidence": [ { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#names_and_taxonomy" } ] }, { "name": "transcription initiation factor TFIID 18 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" } ] }, { "name": "transcription initiation factor TFIID subunit 13", "type": "synonym", "evidence": [ { "id": "NP_001069065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065" } ] } ], "function": [ { "annotation": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.", "evidence": [ { "database": "UniProtKB", "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7#function" }, { "database": "UniProtKB", "id": "Q15543", "url": "https://www.uniprot.org/uniprotkb/Q15543#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAF13", "url": "https://www.uniprot.org/uniprotkb/Q148M7", "locus": { "chromosome": "3", "start_pos": 34312600, "end_pos": 34304625, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062514", "url": "https://www.ensembl.org/id/ENSBTAG00000062514" } ] } } ], "crossref": [ { "id": "Q148M7", "url": "https://alphafold.ebi.ac.uk/entry/Q148M7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07978", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07978", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513065", "url": "https://www.ncbi.nlm.nih.gov/gene/513065", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513065", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513065", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q148M7", "url": "https://www.orthodb.org/?gene=Q148M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11380:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11380:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02269", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02269", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069065", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q148M7-1", "url": "https://www.uniprot.org/uniprotkb/Q148M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS", "length": 124, "header": "sp|Q148M7-1|TAF13_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 13 OS=Bos taurus OX=9913 GN=TAF13 PE=2 SV=1 CANONICAL=Q148M7-1" }, "isoforms": [ { "isoform_ac": "Q148M7-1", "url": "https://www.uniprot.org/uniprotkb/Q148M7/entry#Q148M7-1", "sequence": { "sequence": "MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS", "length": 124, "header": "sp|Q148M7-1|TAF13_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 13 OS=Bos taurus OX=9913 GN=TAF13 PE=2 SV=1 CANONICAL=Q148M7-1" }, "locus": { "chromosome": "3", "start_pos": 34311525, "end_pos": 34304642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104072.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513065", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513065", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "Q148M7", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q148M7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 124, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q148M7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q148M7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q148M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148M7" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone-fold", "eco_id": "ECO_0000305", "start_pos": 32, "end_pos": 74, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17Q87-1", "uniprot_ac": "Q17Q87", "uniprot_id": "SNN_BOVIN", "mass": { "chemical_mass": 9396.0, "monoisotopic_mass": 9396.0 }, "refseq": { "ac": "NP_001107194", "name": "stannin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107194" }, "gene_names": [ { "name": "SNN", "type": "recommended", "evidence": [ { "id": "Q17Q87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ] }, { "name": "SNN", "type": "synonym", "evidence": [ { "id": "NP_001107194", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107194" } ] } ], "protein_names": [ { "name": "Stannin", "type": "recommended", "evidence": [ { "id": "Q17Q87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q87/entry#names_and_taxonomy" } ] }, { "name": "stannin", "type": "synonym", "evidence": [ { "id": "NP_001107194", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107194" } ] } ], "function": [ { "annotation": "Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation.", "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87#function" }, { "database": "UniProtKB", "id": "O75324", "url": "https://www.uniprot.org/uniprotkb/O75324#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNN", "url": "https://www.uniprot.org/uniprotkb/Q17Q87", "locus": { "chromosome": "25", "start_pos": 10363775, "end_pos": 10352360, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068206", "url": "https://www.ensembl.org/id/ENSBTAG00000068206" } ] } } ], "crossref": [ { "id": "Q17Q87", "url": "https://alphafold.ebi.ac.uk/entry/Q17Q87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054404", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054404", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615361", "url": "https://www.ncbi.nlm.nih.gov/gene/615361", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615361", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615361", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCMERKA", "url": "https://omabrowser.org/oma/group/PCMERKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17Q87", "url": "https://www.orthodb.org/?gene=Q17Q87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28564", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28564", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28564:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28564:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001107194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107194", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17Q87-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLTPNGPEVHS", "length": 87, "header": "sp|Q17Q87-1|SNN_BOVIN Isoform 1 of Stannin OS=Bos taurus OX=9913 GN=SNN PE=3 SV=1 CANONICAL=Q17Q87-1" }, "isoforms": [ { "isoform_ac": "Q17Q87-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q87/entry#Q17Q87-1", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLTPNGPEVHS", "length": 87, "header": "sp|Q17Q87-1|SNN_BOVIN Isoform 1 of Stannin OS=Bos taurus OX=9913 GN=SNN PE=3 SV=1 CANONICAL=Q17Q87-1" }, "locus": { "chromosome": "25", "start_pos": 10362771, "end_pos": 10362511, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146843.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146843.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104014.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ], "site_lbl": "Ser49" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615361", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615361", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4F7C0-1", "protein_name": "Stannin", "gene_name": "SNN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLTPTGPEVHG", "length": 87 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GWL4-1", "protein_name": "Stannin", "gene_name": "Snn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTTNGPEVHG", "length": 88 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75324-1", "protein_name": "Stannin", "gene_name": "SNN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG", "length": 88 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61807-1", "protein_name": "Stannin", "gene_name": "Snn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTANSPEVHG", "length": 88 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61808-1", "protein_name": "Stannin", "gene_name": "Snn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTANSPEVHG", "length": 88 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "R4GFS5-1", "protein_name": "Stannin", "gene_name": "SNN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSITDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGEGETKEPFLLVQYSAKGPCVERKAKLTPNGTDVHS", "length": 87 }, "evidence": [ { "id": "Q17Q87", "url": "https://omabrowser.org/oma/group/Q17Q87/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q17Q87", "url": "https://www.uniprot.org/uniprotkb/Q17Q87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17Q87-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 87, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17Q87-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17Q87" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 49 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17Q91-1", "uniprot_ac": "Q17Q91", "uniprot_id": "CHCH7_BOVIN", "mass": { "chemical_mass": 9799.0, "monoisotopic_mass": 9799.0 }, "refseq": { "ac": "NP_001124231", "name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124231" }, "gene_names": [ { "name": "CHCHD7", "type": "recommended", "evidence": [ { "id": "Q17Q91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" } ] }, { "name": "CHCHD7", "type": "synonym", "evidence": [ { "id": "NP_001124231", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124231" } ] } ], "protein_names": [ { "name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "type": "recommended", "evidence": [ { "id": "Q17Q91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q91/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001124231", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124231" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17Q91", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHCHD7", "url": "https://www.uniprot.org/uniprotkb/Q17Q91", "locus": { "chromosome": "14", "start_pos": 23383016, "end_pos": 23376149, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049910", "url": "https://www.ensembl.org/id/ENSBTAG00000049910" } ] } } ], "crossref": [ { "id": "Q17Q91", "url": "https://alphafold.ebi.ac.uk/entry/Q17Q91", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049910", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049910", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616237", "url": "https://www.ncbi.nlm.nih.gov/gene/616237", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616237", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616237", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QELSYKC", "url": "https://omabrowser.org/oma/group/QELSYKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M453", "url": "https://www.orthodb.org/?gene=A0A3Q1M453", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q17Q91", "url": "https://www.orthodb.org/?gene=Q17Q91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46811", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46811", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46811:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46811:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001124231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124231", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M453", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M453", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M453-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M453-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17Q91", "url": "https://www.uniprot.org/uniprotkb/Q17Q91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17Q91-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPMVTRRLRDPDVNPCLSESDASTRCMAENNYDKESCSSHFLKYKNCRKFWNSVMIQRRQNGVKPPMPTAAERDEILGGLGKMPY", "length": 85, "header": "sp|Q17Q91-1|CHCH7_BOVIN Isoform 1 of Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Bos taurus OX=9913 GN=CHCHD7 PE=3 SV=1 CANONICAL=Q17Q91-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M453-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q91/entry#A0A3Q1M453-1", "sequence": { "sequence": "MPMVTRRLRDPDVNPCLSESDASTRCMAENNYDKESCSSHFLKYKNCRKFWDPWALSLGASTLPTCEDSAPTENSVMIQRRQNGVKPPMPTAAERDEILGGLGKMPY", "length": 107, "header": "tr|A0A3Q1M453-1|A0A3Q1M453_BOVIN Computationally mapped isoform of Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Bos taurus OX=9913 GN=CHCHD7 PE=3 SV=1 CANONICAL=Q17Q91-1" }, "locus": { "chromosome": "14", "start_pos": 23382012, "end_pos": 23379291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086516.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086516.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064969.1" } ] } }, { "isoform_ac": "A0AAA9TIK7-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q91/entry#A0AAA9TIK7-1", "sequence": { "sequence": "MPMVTRRLRDPDVNPCLSESDASTRCMAENNYDKESCSSHFLKYKNCRKFWVSLAWSPLQ", "length": 60, "header": "tr|A0AAA9TIK7-1|A0AAA9TIK7_BOVIN Computationally mapped isoform of Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Bos taurus OX=9913 GN=CHCHD7 PE=3 SV=1 CANONICAL=Q17Q91-1" }, "locus": { "chromosome": "14", "start_pos": 23381027, "end_pos": 23379291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096966.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096966.1" } ] } }, { "isoform_ac": "Q17Q91-1", "url": "https://www.uniprot.org/uniprotkb/Q17Q91/entry#Q17Q91-1", "sequence": { "sequence": "MPMVTRRLRDPDVNPCLSESDASTRCMAENNYDKESCSSHFLKYKNCRKFWNSVMIQRRQNGVKPPMPTAAERDEILGGLGKMPY", "length": 85, "header": "sp|Q17Q91-1|CHCH7_BOVIN Isoform 1 of Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Bos taurus OX=9913 GN=CHCHD7 PE=3 SV=1 CANONICAL=Q17Q91-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 69, "start_aa": "Thr", "end_pos": 69, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr69", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616237", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616237", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LYP1-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "Chchd7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPIVTRRLRDPDINPCLSESDASTRCMDENNYDRERCSNYFLKYKNCRRFWNSVMIQRRQNGVQPSMPTAAERDEILRAMQKMPY", "length": 85 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XBC9-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "CHCHD7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKYAQQLRDHDRNPCIAETDASRKCMDDNNYKKDMCTDYFLKYKNCRKFWHDIMMQRKRNGVKPEMPSAEERKKILESVEKPY", "length": 84 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QKA5-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "chchd7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMANKSSAQKVRNADSNPCIEESDNSQRCLDAYNYDKNMCSAYFMKYKSCRKYWHDVMLQRKRSGVKPEMPNAEERQQILTALGGKPY", "length": 88 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8K2Q5-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "Chchd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPMVTRRLRDPDINPCLSESDASTRCMDENNYDRERCSSYFLKYKNCRRFWNSVMIQRRQNGVQPSMPTAAERDEILGAMQKMPY", "length": 85 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BUK0-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "CHCHD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSVTQRLRDPDINPCLSESDASTRCLDENNYDRERCSTYFLRYKNCRRFWNSIVMQRRKNGVKPFMPTAAERDEILRAVGNMPY", "length": 85 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPC2-1", "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "Dmel\\CG4186", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPRNQNAEQDNPCLKEQELSFKCLNKNNFDRDKCEIYFANYNNCKEFWNKVKTERRAKGIAPYLPPLEERDGIKAEYMKGKPQQS", "length": 85 }, "evidence": [ { "id": "Q17Q91", "url": "https://omabrowser.org/oma/group/Q17Q91/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex assembly", "id": "GO:0033108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033108", "evidence": [ { "database": "UniProtKB", "id": "Q17Q91", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q17Q91", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q17Q91", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17Q91-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 85, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17Q91-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17Q91" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17Q91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000255", "start_pos": 13, "end_pos": 55, "start_aa": "Val", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17Q91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 1", "eco_id": "ECO_0000255", "start_pos": 16, "end_pos": 26, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17Q91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17Q91" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 2", "eco_id": "ECO_0000255", "start_pos": 37, "end_pos": 47, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 69 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QF6-1", "uniprot_ac": "Q17QF6", "uniprot_id": "LDOC1_BOVIN", "mass": { "chemical_mass": 17044.0, "monoisotopic_mass": 17044.0 }, "refseq": { "ac": "NP_001075013", "name": "protein LDOC1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075013" }, "gene_names": [ { "name": "LDOC1", "type": "recommended", "evidence": [ { "id": "Q17QF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QF6" } ] }, { "name": "LDOC1", "type": "synonym", "evidence": [ { "id": "NP_001075013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075013" } ] } ], "protein_names": [ { "name": "Protein LDOC1", "type": "recommended", "evidence": [ { "id": "Q17QF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QF6/entry#names_and_taxonomy" } ] }, { "name": "leucine zipper down-regulated in cancer 1", "type": "synonym", "evidence": [ { "id": "NP_001075013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075013" } ] }, { "name": "protein LDOC1", "type": "synonym", "evidence": [ { "id": "NP_001075013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075013" } ] } ], "function": [ { "annotation": "May have an important role in the development and/or progression of some cancers.", "evidence": [ { "database": "UniProtKB", "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LDOC1", "url": "https://www.uniprot.org/uniprotkb/Q17QF6", "locus": {} } ], "crossref": [ { "id": "Q17QF6", "url": "https://alphafold.ebi.ac.uk/entry/Q17QF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "616591", "url": "https://www.ncbi.nlm.nih.gov/gene/616591", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616591", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616591", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QF6", "url": "https://www.orthodb.org/?gene=Q17QF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF16297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001075013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QF6-1", "url": "https://www.uniprot.org/uniprotkb/Q17QF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERATLLRQVRPPSCPVPFPETFDGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDKMKQCFGWDDDEEDEDEYEEDDY", "length": 146, "header": "sp|Q17QF6-1|LDOC1_BOVIN Isoform 1 of Protein LDOC1 OS=Bos taurus OX=9913 GN=LDOC1 PE=2 SV=2 CANONICAL=Q17QF6-1" }, "isoforms": [ { "isoform_ac": "Q17QF6-1", "url": "https://www.uniprot.org/uniprotkb/Q17QF6/entry#Q17QF6-1", "sequence": { "sequence": "MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERATLLRQVRPPSCPVPFPETFDGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDKMKQCFGWDDDEEDEDEYEEDDY", "length": 146, "header": "sp|Q17QF6-1|LDOC1_BOVIN Isoform 1 of Protein LDOC1 OS=Bos taurus OX=9913 GN=LDOC1 PE=2 SV=2 CANONICAL=Q17QF6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616591", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616591", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6" } ], "pmid": "" }, { "name": "cellular response to muramyl dipeptide", "id": "GO:0071225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071225", "evidence": [ { "database": "UniProtKB", "id": "Q17QF6", "url": "https://www.uniprot.org/uniprotkb/Q17QF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QF6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 146, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QF6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QF6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QH8-1", "uniprot_ac": "Q17QH8", "uniprot_id": "D39U1_BOVIN", "mass": { "chemical_mass": 31334.0, "monoisotopic_mass": 31334.0 }, "refseq": { "ac": "NP_001069280", "name": "epimerase family protein SDR39U1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280" }, "gene_names": [ { "name": "SDR39U1", "type": "recommended", "evidence": [ { "id": "Q17QH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH8" } ] }, { "name": "C10H14orf124", "type": "synonym", "evidence": [ { "id": "NP_001069280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280" } ] }, { "name": "C14orf124", "type": "synonym", "evidence": [ { "id": "NP_001069280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280" } ] }, { "name": "SDR39U1", "type": "synonym", "evidence": [ { "id": "NP_001069280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280" } ] } ], "protein_names": [ { "name": "Epimerase family protein SDR39U1", "type": "recommended", "evidence": [ { "id": "Q17QH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH8/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.-", "type": "synonym", "evidence": [ { "id": "Q17QH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH8/entry#names_and_taxonomy" } ] }, { "name": "Short-chain dehydrogenase/reductase family 39U member 1", "type": "synonym", "evidence": [ { "id": "Q17QH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH8/entry#names_and_taxonomy" } ] }, { "name": "epimerase family protein SDR39U1", "type": "synonym", "evidence": [ { "id": "NP_001069280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280" } ] } ], "function": [ { "annotation": "Putative NADP-dependent oxidoreductase.", "evidence": [ { "database": "UniProtKB", "id": "Q17QH8", "url": "https://www.uniprot.org/uniprotkb/Q17QH8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QH8", "url": "https://www.uniprot.org/uniprotkb/Q17QH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDR39U1", "url": "https://www.uniprot.org/uniprotkb/Q17QH8", "locus": { "chromosome": "10", "start_pos": 20734731, "end_pos": 20731294, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004788", "url": "https://www.ensembl.org/id/ENSBTAG00000004788" } ] } } ], "crossref": [ { "id": "Q17QH8", "url": "https://alphafold.ebi.ac.uk/entry/Q17QH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05242", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05242", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520897", "url": "https://www.ncbi.nlm.nih.gov/gene/520897", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520897", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520897", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QH8", "url": "https://www.orthodb.org/?gene=Q17QH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11092:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11092:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08338", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08338", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QH8", "url": "https://www.uniprot.org/uniprotkb/Q17QH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QH8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVLVGGGTGFIGTALTQLLKARGHEVTLISRKPGPDRITWDDLTTSGLPRCDAAVNLAGENILNPLRRWNAAFQKEVLSSRLETTQTLARAIAKAPQPPQAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVVVRSGVVLGRGGGAIGHMLLPFRLGLGGPIGSGHQFFPWIHIRDLAGILAHALETSHVQGILNGVAPASSTTNAEFARALGTALGRPAFIPLPSAVVQAVFGRERAVMLLEGQKVVPRRTLAAGYRYSFPELGAALKEVIA", "length": 294, "header": "sp|Q17QH8-1|D39U1_BOVIN Isoform 1 of Epimerase family protein SDR39U1 OS=Bos taurus OX=9913 GN=SDR39U1 PE=2 SV=1 CANONICAL=Q17QH8-1" }, "isoforms": [ { "isoform_ac": "Q17QH8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QH8/entry#Q17QH8-1", "sequence": { "sequence": "MRVLVGGGTGFIGTALTQLLKARGHEVTLISRKPGPDRITWDDLTTSGLPRCDAAVNLAGENILNPLRRWNAAFQKEVLSSRLETTQTLARAIAKAPQPPQAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVVVRSGVVLGRGGGAIGHMLLPFRLGLGGPIGSGHQFFPWIHIRDLAGILAHALETSHVQGILNGVAPASSTTNAEFARALGTALGRPAFIPLPSAVVQAVFGRERAVMLLEGQKVVPRRTLAAGYRYSFPELGAALKEVIA", "length": 294, "header": "sp|Q17QH8-1|D39U1_BOVIN Isoform 1 of Epimerase family protein SDR39U1 OS=Bos taurus OX=9913 GN=SDR39U1 PE=2 SV=1 CANONICAL=Q17QH8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:520897", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520897", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q17QH8", "url": "https://www.uniprot.org/uniprotkb/Q17QH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 294, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QH8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QH9-1", "uniprot_ac": "Q17QH9", "uniprot_id": "DRC10_BOVIN", "mass": { "chemical_mass": 51623.0, "monoisotopic_mass": 51623.0 }, "refseq": { "ac": "NP_001069074", "name": "dynein regulatory complex subunit 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" }, "gene_names": [ { "name": "DRC10", "type": "recommended", "evidence": [ { "id": "Q17QH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH9" } ] }, { "name": "DRC10", "type": "synonym", "evidence": [ { "id": "NP_001069074", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" } ] }, { "name": "IQCD", "type": "synonym", "evidence": [ { "id": "NP_001069074", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" }, { "id": "Q17QH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH9" } ] } ], "protein_names": [ { "name": "Dynein regulatory complex subunit 10", "type": "recommended", "evidence": [ { "id": "Q17QH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH9/entry#names_and_taxonomy" } ] }, { "name": "IQ domain-containing protein D", "type": "synonym", "evidence": [ { "id": "NP_001069074", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" }, { "id": "Q17QH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH9/entry#names_and_taxonomy" } ] }, { "name": "dynein regulatory complex protein 10", "type": "synonym", "evidence": [ { "id": "NP_001069074", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" } ] }, { "name": "dynein regulatory complex subunit 10", "type": "synonym", "evidence": [ { "id": "NP_001069074", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074" } ] } ], "function": [ { "annotation": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.", "evidence": [ { "database": "UniProtKB", "id": "Q17QH9", "url": "https://www.uniprot.org/uniprotkb/Q17QH9#function" }, { "database": "UniProtKB", "id": "A8J0N6", "url": "https://www.uniprot.org/uniprotkb/A8J0N6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QH9", "url": "https://www.uniprot.org/uniprotkb/Q17QH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRC10", "url": "https://www.uniprot.org/uniprotkb/Q17QH9", "locus": {} } ], "crossref": [ { "id": "Q17QH9", "url": "https://alphafold.ebi.ac.uk/entry/Q17QH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001806", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001806", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513272", "url": "https://www.ncbi.nlm.nih.gov/gene/513272", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513272", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513272", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKIQKYW", "url": "https://omabrowser.org/oma/group/AKIQKYW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QH9", "url": "https://www.orthodb.org/?gene=Q17QH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31598", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31598", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31598:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31598:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069074", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QH9", "url": "https://www.uniprot.org/uniprotkb/Q17QH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QH9-1", "url": "https://www.uniprot.org/uniprotkb/Q17QH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALDVLTVAPLYQGPDINKIRLIAQTTKKSTIPPKALTPARSKLTTIETKRIMSVLDETIHKVELVSLLSHAASESKTSEGMLGPDIAKAVREHEDLCQALLDRVSYLQEEERKLQEAEDFEDEAWFRERLFAMDLQKSQLPPLMQEIKESTKNVVRLLLSNPQAASLLQAQTLGRSKEAQCFIDSLVELRGFLFEKLLTSPMEARDKIQFIQDITRRNRRHQEIIDTLENELAACVRNRNAEVEKENFVIQELKNHLHQVLRFSENSLLRTKQEAEKQQKADFRASQARVATVQQEILVLQSQFYNLVMENRDTEQALRKKKYKVETEIENWIQKYDSEMSEKQDEYEELDIIHKEEQLQLEELKKRHDVLVEEFSQIQAEREILTKKRLEDEQEMVRMVRAATLIQALWKGYLVRSMLKSKKKKRGKGKGEKKGKGKGKGKK", "length": 444, "header": "sp|Q17QH9-1|DRC10_BOVIN Isoform 1 of Dynein regulatory complex subunit 10 OS=Bos taurus OX=9913 GN=DRC10 PE=1 SV=1 CANONICAL=Q17QH9-1" }, "isoforms": [ { "isoform_ac": "Q17QH9-1", "url": "https://www.uniprot.org/uniprotkb/Q17QH9/entry#Q17QH9-1", "sequence": { "sequence": "MALDVLTVAPLYQGPDINKIRLIAQTTKKSTIPPKALTPARSKLTTIETKRIMSVLDETIHKVELVSLLSHAASESKTSEGMLGPDIAKAVREHEDLCQALLDRVSYLQEEERKLQEAEDFEDEAWFRERLFAMDLQKSQLPPLMQEIKESTKNVVRLLLSNPQAASLLQAQTLGRSKEAQCFIDSLVELRGFLFEKLLTSPMEARDKIQFIQDITRRNRRHQEIIDTLENELAACVRNRNAEVEKENFVIQELKNHLHQVLRFSENSLLRTKQEAEKQQKADFRASQARVATVQQEILVLQSQFYNLVMENRDTEQALRKKKYKVETEIENWIQKYDSEMSEKQDEYEELDIIHKEEQLQLEELKKRHDVLVEEFSQIQAEREILTKKRLEDEQEMVRMVRAATLIQALWKGYLVRSMLKSKKKKRGKGKGEKKGKGKGKGKK", "length": 444, "header": "sp|Q17QH9-1|DRC10_BOVIN Isoform 1 of Dynein regulatory complex subunit 10 OS=Bos taurus OX=9913 GN=DRC10 PE=1 SV=1 CANONICAL=Q17QH9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513272", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513272", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X4Y4-1", "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "IQCD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTEAAEKAVISVDAMKVLDPRWLKPNSIETERILSVLDETIAKLELSSLIPRIIGSLDRFADLLGPEITASLMEYQQLSNQMEHLLVAAEEEGTAEAEEQRGSLHLLEQHLKCSVRNILRLLLAIPSLCKALKYEVWAREPATEAFIKAFGEFRNFMLERLLTSPTKEEETVQLMEDISLRINKNTETITALQAELAAAIRAQDEEIQNKDNMIKDLKNSMEILDECCKDNILQVKWEGEKQQKEELRASQARCARLQQNIQQLEAQFNKLVLEHRASELALRKRKCRLETEILNWIQAYDTDMAEKQAEFEEVHAAYTKEKAELSLLMEKHAVLLQEYSQIEEERRINEEKKKQALEELAVLTLAATRIQAFWRGYLIRSTFKPKKKKKGKGKGKGKGKGKDKKEKK", "length": 409 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1Z8V5-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG13168", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDTTAERQVRLEGVERVLKMSQERIKIAMIIPKLLENPEKLKSVLKDTCYEEVLEPIDDMIRHLGKQSGRSKLPHDHTTMRIVDFFLVNHSIHRFFPHLKKNLNERDRQLLAAFHFLLESAHVHLHRSSRSEITKERKLHAIFHQNVDIKKKIKELKASLAFQKVIGKWKTAAKGIYLMKVEEDLANKKWQNNVAIQNEIEKCHRTMRSYHKSSMDRQKELEEELQNARESYEKMTKKHLAEEHELRSEKNKLLLQLQSMLKKYDTSLGEKMRENLVAEDQYLAAKKVLDDFMVQYRQEERIYKNIVVKREEEERRVQQEKLVIFMMNRAAGKIQKYWRKWKKDQRKRKRQGKGKGKKGK", "length": 360 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1RKB1-1", "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "DRC10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALDILAVAPLYQGPDINKIRLMAETTKKSTTPPKPLTPSRTKLTTIETKRIMSVLDETIHKVELVTLLSNVASSSQSLEGMLGEDIMKAVREHVDLCQTLLDHVNYLQEEEQRLQEEEGFEDEPWFRDLVFSIELQKSRLPPLRQQIRESTKNVLRLLLRNPQAASLLQVQSLGRSEEAQSFIDSLVELRGFLFEKLLTSPMEARDKTQFIQDITRRNRRNQEIIDTLENELAACMRNRDAEVEKENFVVQELKNHLHQVLKFSENSLLRTKQEAEKQQKADFRASQARVAKIQQEILLLRSQFHNLVMENREAEQALRKKKYKVETEIENWIQKYDLEMSEKQDEYEELDIIHKEEKLQLEELKQRHSVLVEEFSQIQAEREIKAKERLEAEQEMVRMVRAATLIQALWKGYLVRSMLRSKKKKRNKGKVKDKEKGKGKEKGKGKGKEKGKGKEKGKGKKGKGKK", "length": 467 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F6P8U0-1", "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "drc10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMDVDAATIPNKTKADSPKTINPSRKVLSCREAKLILGVLDECIHQMETASLLPTLLKSSEALSLSLEEEVVKALKEHQKLEEKYQSIALDGNHDQNELQVEKAKSAKLVQDSFRKIIRLLRATPTTKVVLKRIEPNTTGEMGSQKIRNGLCELREVVLERLLTTPAEEKESRKMMLEVSQRHSANQKLIEALEKEVAEANKNKDAEISTLNNKVLQLRRTLHQMGKGLEEFVMRTQQDAEKQSHSDRKTSDGKRARLQQEASQLRTQLNNAIKASRGREQDLRKEKYKEETEIENLIQKYDAEIGEKQTELEEMTRMHEEDQMELTELEKRFDTLDLEYSQIMEERQEAQELREQQERERQIQSQAATVIQAYWRGFCVRKAKKVSAKPKKGKKGKGKKGK", "length": 402 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96DY2-1", "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "DRC10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEVEKENFVIQELKNHLHQVLKFSENSLVRTKQEAEKQQKADFRASQARVAKIQQEILQLQSQFYNLVMENREAEQALRKKKYKVETEIENWIQKYDTEMGEKQEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKGKK", "length": 449 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D3V1-1", "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "Drc10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALDQVSIPPSYHGLAIQRIPLRTGLVPAEPMKTLVPSKSKLNTIEAKRIMSVLDEAIHKIELITLMSYMESHPEALEDTLPEDFVRALREHLDIGQTLVERASILQRRHKKLEEEEEAEETRNQERLLSLELHKVNLLTLAHQFRDSTKTVLRLVLGEPQFTRLLQVQAPGRSPGAQCLLDGLVELRGFLFEKLLTSPMEVREKNQFIQDISRRSERNQEVIDDLQAELANVLKNKESEVEKENFVIQELKNHLHQVFKFSENSLLRTKQEAEKQQKVDFRASQVRLAKTQQDILALRAQYHNLVMENREAEQALRKKKYKVETEIENWIQKYDMEMGEKQDEYEDLESIHKEEKLQLEELRERHAVLVEEFSQIRAESEINSKKRVEAEREMVRMVRAATLIQAVWKGYLVRSILRSKKKKRGKGKGKDKGKGKEKPKEEKAKEKKPKAKGKGKKK", "length": 458 }, "evidence": [ { "id": "Q17QH9", "url": "https://omabrowser.org/oma/group/Q17QH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 444, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QH9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17QH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QH9" }, { "id": "PRU00116", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQ", "eco_id": "ECO_0000255", "start_pos": 400, "end_pos": 429, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QK1-1", "uniprot_ac": "Q17QK1", "uniprot_id": "RUN3A_BOVIN", "mass": { "chemical_mass": 49462.0, "monoisotopic_mass": 49462.0 }, "refseq": { "ac": "NP_001069790", "name": "RUN domain-containing protein 3A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069790" }, "gene_names": [ { "name": "RUNDC3A", "type": "recommended", "evidence": [ { "id": "Q17QK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ] }, { "name": "RUNDC3A", "type": "synonym", "evidence": [ { "id": "NP_001069790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069790" } ] } ], "protein_names": [ { "name": "RUN domain-containing protein 3A", "type": "recommended", "evidence": [ { "id": "Q17QK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QK1/entry#names_and_taxonomy" } ] }, { "name": "RUN domain-containing protein 3A", "type": "synonym", "evidence": [ { "id": "NP_001069790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069790" } ] } ], "function": [ { "annotation": "May act as an effector of RAP2A in neuronal cells.", "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RUNDC3A", "url": "https://www.uniprot.org/uniprotkb/Q17QK1", "locus": { "chromosome": "19", "start_pos": 44125625, "end_pos": 44116205, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001615", "url": "https://www.ensembl.org/id/ENSBTAG00000001615" } ] } } ], "crossref": [ { "id": "Q17QK1", "url": "https://alphafold.ebi.ac.uk/entry/Q17QK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001615", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001615", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17699", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17699", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614322", "url": "https://www.ncbi.nlm.nih.gov/gene/614322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614322", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614322", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWEYVRL", "url": "https://omabrowser.org/oma/group/FWEYVRL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QK1", "url": "https://www.orthodb.org/?gene=Q17QK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46251", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46251", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46251:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46251:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069790", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QK1-1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEASFVQTTMALGLSSKKASSRNVAVERRNLITVCRFSVKTLLEKYTTEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMMREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGDHAPLAQGSKDLTTRLVNQWPSLGTLSGAEGANNPKLYRRHSFMSTEPLSAEASLSSDSQRLGEGKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "length": 441, "header": "sp|Q17QK1-1|RUN3A_BOVIN Isoform 1 of RUN domain-containing protein 3A OS=Bos taurus OX=9913 GN=RUNDC3A PE=2 SV=1 CANONICAL=Q17QK1-1" }, "isoforms": [ { "isoform_ac": "Q17QK1-1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1/entry#Q17QK1-1", "sequence": { "sequence": "MEASFVQTTMALGLSSKKASSRNVAVERRNLITVCRFSVKTLLEKYTTEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMMREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGDHAPLAQGSKDLTTRLVNQWPSLGTLSGAEGANNPKLYRRHSFMSTEPLSAEASLSSDSQRLGEGKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "length": 441, "header": "sp|Q17QK1-1|RUN3A_BOVIN Isoform 1 of RUN domain-containing protein 3A OS=Bos taurus OX=9913 GN=RUNDC3A PE=2 SV=1 CANONICAL=Q17QK1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 399, "start_aa": "Thr", "end_pos": 399, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr399", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ], "site_lbl": "Thr210" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ], "site_lbl": "Ser227" }, { "start_pos": 411, "end_pos": 411, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ], "site_lbl": "Ser411" }, { "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q17QK1", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" } ], "site_lbl": "Ser414" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614322", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614322", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LRZ9-1", "protein_name": "RUN domain-containing protein 3A", "gene_name": "Rundc3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLPDPPPPPRTGLIPGDHAPLAQGSKELTTALVNQWPSLSTLSRPEGASNSKLFRRHSFMSTEPLSAEASLSSDSQRLGEGKRDEEPWGPIGSSEPN", "length": 413 }, "evidence": [ { "id": "Q17QK1", "url": "https://omabrowser.org/oma/group/Q17QK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QCE8-1", "protein_name": "RUN domain-containing protein 3A", "gene_name": "rundc3aa", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAMGLTSKKTSSRNIGVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFINFAAILEHILSHRFKGPGGWFSSDGQRSFWDYIRLACSKVYNNCISSIESIENISTSRAKGRAWIRVALMEKRLSEYVAIALRDTRTTRRFYDDGAVMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPAVIDYTPYLKFTQSYDYLSDEEDRRSVDSSASDESVAEHPYIPLVTDEETWSNKCRKMEQRFKIVNAQKGYLEELVRLRESQLKNVETENKRLDAKLEELQVQSQQEKKELEAIILELQAQITGIIPCEPSHLVKGLSIPLINQWATAQATNNQGNVKLFRRRSFHSLDLSADLSLNSDSQKEDGNQNGDTVWSAAKDNTPSMLGLCGSLASLPSCKSLASLKSSEYLVNISTEPSPALSPS", "length": 424 }, "evidence": [ { "id": "Q17QK1", "url": "https://omabrowser.org/oma/group/Q17QK1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O08576-1", "protein_name": "RUN domain-containing protein 3A", "gene_name": "Rundc3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPASWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGDHAPLAQGSKELTTSLVNQWPSLSTLHRPEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEAKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "length": 446 }, "evidence": [ { "id": "Q17QK1", "url": "https://omabrowser.org/oma/group/Q17QK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q59EK9-1", "protein_name": "RUN domain-containing protein 3A", "gene_name": "RUNDC3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "length": 446 }, "evidence": [ { "id": "Q17QK1", "url": "https://omabrowser.org/oma/group/Q17QK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QK1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17QK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QK1" }, { "id": "PRU00178", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RUN", "eco_id": "ECO_0000255", "start_pos": 52, "end_pos": 184, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 399 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 210, 227, 411, 414 ], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QL9-1", "uniprot_ac": "Q17QL9", "uniprot_id": "T184C_BOVIN", "mass": { "chemical_mass": 50000.0, "monoisotopic_mass": 50000.0 }, "refseq": { "ac": "NP_001068648", "name": "transmembrane protein 184C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648" }, "gene_names": [ { "name": "TMEM184C", "type": "recommended", "evidence": [ { "id": "Q17QL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QL9" } ] }, { "name": "TMEM184C", "type": "synonym", "evidence": [ { "id": "NP_001068648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648" } ] }, { "name": "TMEM34", "type": "synonym", "evidence": [ { "id": "NP_001068648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648" }, { "id": "Q17QL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QL9" } ] } ], "protein_names": [ { "name": "Transmembrane protein 184C", "type": "recommended", "evidence": [ { "id": "Q17QL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QL9/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 34", "type": "synonym", "evidence": [ { "id": "Q17QL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QL9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 184C", "type": "synonym", "evidence": [ { "id": "NP_001068648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648" } ] }, { "name": "transmembrane protein 34", "type": "synonym", "evidence": [ { "id": "NP_001068648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648" } ] } ], "function": [ { "annotation": "Possible tumor suppressor which may play a role in cell growth.", "evidence": [ { "database": "UniProtKB", "id": "Q17QL9", "url": "https://www.uniprot.org/uniprotkb/Q17QL9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QL9", "url": "https://www.uniprot.org/uniprotkb/Q17QL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM184C", "url": "https://www.uniprot.org/uniprotkb/Q17QL9", "locus": { "chromosome": "17", "start_pos": 10487575, "end_pos": 10517260, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010376", "url": "https://www.ensembl.org/id/ENSBTAG00000010376" } ] } } ], "crossref": [ { "id": "Q17QL9", "url": "https://alphafold.ebi.ac.uk/entry/Q17QL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "504966", "url": "https://www.ncbi.nlm.nih.gov/gene/504966", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504966", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504966", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QL9", "url": "https://www.orthodb.org/?gene=Q17QL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QL9", "url": "https://www.uniprot.org/uniprotkb/Q17QL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QL9-1", "url": "https://www.uniprot.org/uniprotkb/Q17QL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCTCTWRNWRQWIRPLAVVLYLLSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPSIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLIIEAKDQQKHFPPLCCCPPWTMGEVLLFRCKLGVLQYTVVRPFTTIIALVCELLDIYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVVIALLVKVGVISEKHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKPYVQEAEEGSCFDSFLAMWDVSDIRDDISEQVRHVGRTVMGHPRKKFFPEDQDQNEHTSLLSSSSQDALSVASSVPPSPVGHYQGFGHTVTPQTTPTTANASDDTGNDAAGVREEPSEKPVAS", "length": 438, "header": "sp|Q17QL9-1|T184C_BOVIN Isoform 1 of Transmembrane protein 184C OS=Bos taurus OX=9913 GN=TMEM184C PE=2 SV=1 CANONICAL=Q17QL9-1" }, "isoforms": [ { "isoform_ac": "Q17QL9-1", "url": "https://www.uniprot.org/uniprotkb/Q17QL9/entry#Q17QL9-1", "sequence": { "sequence": "MPCTCTWRNWRQWIRPLAVVLYLLSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPSIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLIIEAKDQQKHFPPLCCCPPWTMGEVLLFRCKLGVLQYTVVRPFTTIIALVCELLDIYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVVIALLVKVGVISEKHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKPYVQEAEEGSCFDSFLAMWDVSDIRDDISEQVRHVGRTVMGHPRKKFFPEDQDQNEHTSLLSSSSQDALSVASSVPPSPVGHYQGFGHTVTPQTTPTTANASDDTGNDAAGVREEPSEKPVAS", "length": 438, "header": "sp|Q17QL9-1|T184C_BOVIN Isoform 1 of Transmembrane protein 184C OS=Bos taurus OX=9913 GN=TMEM184C PE=2 SV=1 CANONICAL=Q17QL9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504966", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504966", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q17QL9", "url": "https://www.uniprot.org/uniprotkb/Q17QL9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q17QL9", "url": "https://www.uniprot.org/uniprotkb/Q17QL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 438, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 415, "end_pos": 417 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QM6-1", "uniprot_ac": "Q17QM6", "uniprot_id": "EFHD1_BOVIN", "mass": { "chemical_mass": 26540.0, "monoisotopic_mass": 26540.0 }, "refseq": { "ac": "NP_001069300", "name": "EF-hand domain-containing protein D1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300" }, "gene_names": [ { "name": "EFHD1", "type": "recommended", "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ] }, { "name": "EFHD1", "type": "synonym", "evidence": [ { "id": "NP_001069300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300" } ] } ], "protein_names": [ { "name": "EF-hand domain-containing protein D1", "type": "recommended", "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6/entry#names_and_taxonomy" } ] }, { "name": "EF-hand domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6/entry#names_and_taxonomy" } ] }, { "name": "EF-hand domain-containing protein D1", "type": "synonym", "evidence": [ { "id": "NP_001069300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300" } ] }, { "name": "Swiprosin-2", "type": "synonym", "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6/entry#names_and_taxonomy" } ] }, { "name": "swiprosin-2", "type": "synonym", "evidence": [ { "id": "NP_001069300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300" } ] } ], "function": [ { "annotation": "Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "database": "UniProtKB", "id": "Q9D4J1", "url": "https://www.uniprot.org/uniprotkb/Q9D4J1#function" }, { "database": "UniProtKB", "id": "Q9BUP0", "url": "https://www.uniprot.org/uniprotkb/Q9BUP0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFHD1", "url": "https://www.uniprot.org/uniprotkb/Q17QM6", "locus": { "chromosome": "3", "start_pos": 112440867, "end_pos": 112396798, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014596", "url": "https://www.ensembl.org/id/ENSBTAG00000014596" } ] } } ], "crossref": [ { "id": "Q17QM6", "url": "https://alphafold.ebi.ac.uk/entry/Q17QM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014596", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014596", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522462", "url": "https://www.ncbi.nlm.nih.gov/gene/522462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVKHTYR", "url": "https://omabrowser.org/oma/group/EVKHTYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QM6", "url": "https://www.orthodb.org/?gene=Q17QM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13025:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13025:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069300", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QM6-1", "url": "https://www.uniprot.org/uniprotkb/Q17QM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEELASKLQRRLQWEEGDSGLQPAPGAAPDPEPQPQPPAWAPTARADAELSAQLNRRLDINEGAARPRRCKVFHPYSEFPEFSRRLIKDLESMFKLYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLMALAKLSEIDVALEGVKGAKDFFEAKVQALSCASKFEAELKAEQDERKREEEKRKVRQAAFRELKAAFSA", "length": 236, "header": "sp|Q17QM6-1|EFHD1_BOVIN Isoform 1 of EF-hand domain-containing protein D1 OS=Bos taurus OX=9913 GN=EFHD1 PE=2 SV=1 CANONICAL=Q17QM6-1" }, "isoforms": [ { "isoform_ac": "Q17QM6-1", "url": "https://www.uniprot.org/uniprotkb/Q17QM6/entry#Q17QM6-1", "sequence": { "sequence": "MASEELASKLQRRLQWEEGDSGLQPAPGAAPDPEPQPQPPAWAPTARADAELSAQLNRRLDINEGAARPRRCKVFHPYSEFPEFSRRLIKDLESMFKLYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLMALAKLSEIDVALEGVKGAKDFFEAKVQALSCASKFEAELKAEQDERKREEEKRKVRQAAFRELKAAFSA", "length": 236, "header": "sp|Q17QM6-1|EFHD1_BOVIN Isoform 1 of EF-hand domain-containing protein D1 OS=Bos taurus OX=9913 GN=EFHD1 PE=2 SV=1 CANONICAL=Q17QM6-1" }, "locus": { "chromosome": "3", "start_pos": 112439772, "end_pos": 112396875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139440.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139440.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106760.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522462", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A9T5-1", "protein_name": "EF-hand domain family, member D1", "gene_name": "Efhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSEELACKLQRRLRLETRAETHQDSPQAAPCTAPAGHREPEPPAPAPTVSADSELNLKLSSRLNIHQGAVRSRRSKVFNPYTEFPEFSRRLLKDLERMFKTYDAGKDGFIDLMELKLMMEKLGAPQTHLGLKNMIQEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLLALAKFSEINVALEGVRGAKNFFEAKAQALACSSKFEAELKAEQDERKREEEARRLRQAAFRELKAAFSA", "length": 240 }, "evidence": [ { "id": "Q17QM6", "url": "https://omabrowser.org/oma/group/Q17QM6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SMT0-1", "protein_name": "EF-hand domain family member D1", "gene_name": "EFHD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASEELASKLQRRLQWEEMEEGGPQPEPRAAPVPEPQPQPPARAPIARADAELSVQLNRRLDINEGAARPRRCKVFHPYSEFPEFSRRLIKDLESMFKLYDAGRDGYIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLMVLAKLSEIDVALEGVKGAKDFFEAKVQALSSASKFEAELKAEQEERKQAEEKRKLRQAAFRELKAAFST", "length": 237 }, "evidence": [ { "id": "Q17QM6", "url": "https://omabrowser.org/oma/group/Q17QM6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BUP0-1", "protein_name": "EF-hand domain-containing protein D1", "gene_name": "EFHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEELACKLERRLRREEAEESGPQLAPLGAPAPEPKPEPEPPARAPTASADAELSAQLSRRLDINEGAARPRRCRVFNPYTEFPEFSRRLIKDLESMFKLYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLMALAKLSEIDVALEGVKGAKNFFEAKVQALSSASKFEAELKAEQDERKREEEERRLRQAAFQKLKANFNT", "length": 239 }, "evidence": [ { "id": "Q17QM6", "url": "https://omabrowser.org/oma/group/Q17QM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D4J1-1", "protein_name": "EF-hand domain-containing protein D1", "gene_name": "Efhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSEELACKLQRRLRLEVRAETDQGDPQPAPCDAPAGHPEPEPPARAPTASADSELNLKLSRRLDIHQGTARPGRSKVFNPYTEFPEFSRRLLKDLEKMFKTYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLLALAKFSEIDVALEGVRGAKNFFEAKAQALSCSSKFEAELKAEQEERKREEEARRLRQAAFRELKAAFSA", "length": 240 }, "evidence": [ { "id": "Q17QM6", "url": "https://omabrowser.org/oma/group/Q17QM6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "pmid": "" }, { "name": "calcium ion sensor activity", "id": "GO:0061891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061891", "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of cellular hyperosmotic salinity response", "id": "GO:1900069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900069", "evidence": [ { "database": "UniProtKB", "id": "Q17QM6", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QM6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 236, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QM6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QM6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 1", "eco_id": "ECO_0000255", "start_pos": 87, "end_pos": 122, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 2", "eco_id": "ECO_0000255", "start_pos": 123, "end_pos": 158, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 100, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 100, "end_pos": 100, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 104, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 104, "end_pos": 104, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 111, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 111, "end_pos": 111, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 136, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 136, "end_pos": 136, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 138, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 138, "end_pos": 138, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 140, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 140, "end_pos": 140, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 142, "amino_acid": "Lys", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 142, "end_pos": 142, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6#function" }, { "id": "Q17QM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM6" } ], "binding_site_uniprot": 147, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000305", "start_pos": 147, "end_pos": 147, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QN8-1", "uniprot_ac": "Q17QN8", "uniprot_id": "SPRNG_BOVIN", "mass": { "chemical_mass": 23488.0, "monoisotopic_mass": 23488.0 }, "refseq": { "ac": "NP_001069491", "name": "SREBP regulating gene protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" }, "gene_names": [ { "name": "SPRING1", "type": "recommended", "evidence": [ { "id": "Q17QN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QN8" } ] }, { "name": "SPRING", "type": "recommended", "evidence": [ { "id": "Q17QN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QN8" } ] }, { "name": "C12orf49", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "C17H12orf49", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "C9H12orf49", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "SPRING1", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "SPRING", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] } ], "protein_names": [ { "name": "SREBP regulating gene protein", "type": "recommended", "evidence": [ { "id": "Q17QN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QN8/entry#names_and_taxonomy" } ] }, { "name": "SREBP regulating gene protein", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "UPF0454 protein C12orf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] }, { "name": "chromosome 17 C12orf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491" } ] } ], "function": [ { "annotation": "Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.", "evidence": [ { "database": "UniProtKB", "id": "Q17QN8", "url": "https://www.uniprot.org/uniprotkb/Q17QN8#function" }, { "database": "UniProtKB", "id": "Q9H741", "url": "https://www.uniprot.org/uniprotkb/Q9H741#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QN8", "url": "https://www.uniprot.org/uniprotkb/Q17QN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPRING", "url": "https://www.uniprot.org/uniprotkb/Q17QN8", "locus": {} } ], "crossref": [ { "id": "Q17QN8", "url": "https://alphafold.ebi.ac.uk/entry/Q17QN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047139", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047139", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534423", "url": "https://www.ncbi.nlm.nih.gov/gene/534423", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534423", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534423", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CNTTSHC", "url": "https://omabrowser.org/oma/group/CNTTSHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QN8", "url": "https://www.orthodb.org/?gene=Q17QN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13481", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13481", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13481:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13481:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069491", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QN8", "url": "https://www.uniprot.org/uniprotkb/Q17QN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QN8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLTSTFKQEERAVRDRNLLQVQDHDQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERRDLLVNGCCNVNVPGTKQYCCDGCLSSGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205, "header": "sp|Q17QN8-1|SPRNG_BOVIN Isoform 1 of SREBP regulating gene protein OS=Bos taurus OX=9913 GN=SPRING PE=2 SV=1 CANONICAL=Q17QN8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZQS2-1", "url": "https://www.uniprot.org/uniprotkb/Q17QN8/entry#A0AAF6ZQS2-1", "sequence": { "sequence": "MCKSCLRTPTEERAVRDRNLLQVQDHDQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERRDLLVNGCCNVNVPGTKQYCCDGCLSSGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 178, "header": "tr|A0AAF6ZQS2-1|A0AAF6ZQS2_BOVIN Computationally mapped isoform of SREBP regulating gene protein OS=Bos taurus OX=9913 GN=SPRING1 PE=3 SV=2 CANONICAL=Q17QN8-1" }, "locus": { "chromosome": "17", "start_pos": 58266022, "end_pos": 58258300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063283.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063283.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055975.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055975.3" } ] } }, { "isoform_ac": "Q17QN8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QN8/entry#Q17QN8-1", "sequence": { "sequence": "MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLTSTFKQEERAVRDRNLLQVQDHDQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERRDLLVNGCCNVNVPGTKQYCCDGCLSSGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205, "header": "sp|Q17QN8-1|SPRNG_BOVIN Isoform 1 of SREBP regulating gene protein OS=Bos taurus OX=9913 GN=SPRING PE=2 SV=1 CANONICAL=Q17QN8-1" }, "locus": { "chromosome": "17", "start_pos": 58266022, "end_pos": 58250617, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146023.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146023.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104542.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 67, "start_aa": "Asn", "end_pos": 67, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn67", "evidence": [ { "id": "Q17QN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QN8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534423", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534423", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480VC18-1", "protein_name": "SREBP regulating gene protein", "gene_name": "SPRING1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLTSTFKQEERAVRDRNLLQVQDHDQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPGTKQYCCDGCLSNGCCSAYEYCVSCCLQPSKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FW99-1", "protein_name": "SREBP regulating gene protein", "gene_name": "Spring1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLNLAALLWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQIQDREQPIPWKVQFNLGNSSRPSNQCRNSVQGKHLITDELGEASPGSQDVHLWLSGYVCERKDLLANGCCDVTVPSTKQYCCDGCLANGCCEAYEHCVSCCLQPSKQLLLERFLNRAAMAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 220 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZTN6-1", "protein_name": "SREBP regulating gene protein", "gene_name": "Spring1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLNLAALLWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAIRDRNLLQVQDREQPIPWKVQFNLGNSSRPSNQCRNSVQGKHLITDELGYVCERKDLLANGCCDVSVPSTKQYCCNGCLANGCCEAYEYCVSCCLQPSKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZJE4-1", "protein_name": "SREBP regulating gene protein", "gene_name": "SPRING", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVPCGAVLWRRLLRKRWVLGVVFGLSLVYFLSSTFKQEERTVRDRNLLQVQEHEQPILWKEQFSSGNGSHLSNQCRNSVQGKLLITDELGYICERKDLLVNGCCNVNVPSTKLYSCDSCLPNGCCSVYEYCVSCCLQPSKQHLLERFLNRAAMAFQNLFMAVEDRFELCLAKCRTSSQSVQHENTYRDPIAKYCYGEYPPELLPV", "length": 205 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BTG6-1", "protein_name": "SREBP regulating gene protein", "gene_name": "Spring1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLNLAALLWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVQDREQPIPWKVQFNLGNSSRPSNQCRNSVQGKHLLTDELGYVCERKDLLANGCCDVSVPSTKQYCCDGCLANGCCEAYEYCVSCCLQPSKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H741-1", "protein_name": "SREBP regulating gene protein", "gene_name": "SPRING1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVHDHNQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPSTKQYCCDGCWPNGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA", "length": 205 }, "evidence": [ { "id": "Q17QN8", "url": "https://omabrowser.org/oma/group/Q17QN8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q17QN8", "url": "https://www.uniprot.org/uniprotkb/Q17QN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of SREBP signaling pathway", "id": "GO:2000640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000640", "evidence": [ { "database": "UniProtKB", "id": "Q17QN8", "url": "https://www.uniprot.org/uniprotkb/Q17QN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QN8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QN8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QN8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 67 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QP1-1", "uniprot_ac": "Q17QP1", "uniprot_id": "ABHD8_BOVIN", "mass": { "chemical_mass": 46833.0, "monoisotopic_mass": 46833.0 }, "refseq": { "ac": "NP_001071591", "name": "protein ABHD8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591" }, "gene_names": [ { "name": "ABHD8", "type": "recommended", "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ] }, { "name": "ABHD8", "type": "synonym", "evidence": [ { "id": "NP_001071591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591" } ] } ], "protein_names": [ { "name": "Protein ABHD8", "type": "recommended", "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1/entry#names_and_taxonomy" } ] }, { "name": "3.-.-.-", "type": "synonym", "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1/entry#names_and_taxonomy" } ] }, { "name": "Abhydrolase domain-containing protein 8", "type": "synonym", "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1/entry#names_and_taxonomy" } ] }, { "name": "Alpha/beta hydrolase domain-containing protein 8", "type": "synonym", "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1/entry#names_and_taxonomy" } ] }, { "name": "abhydrolase domain-containing protein 8", "type": "synonym", "evidence": [ { "id": "NP_001071591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591" } ] }, { "name": "alpha/beta hydrolase domain-containing protein 8", "type": "synonym", "evidence": [ { "id": "NP_001071591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591" } ] }, { "name": "protein ABHD8", "type": "synonym", "evidence": [ { "id": "NP_001071591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591" } ] } ], "function": [ { "annotation": "Negatively regulates NLRP3-driven inflammation. Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1#function" }, { "database": "UniProtKB", "id": "Q96I13", "url": "https://www.uniprot.org/uniprotkb/Q96I13#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABHD8", "url": "https://www.uniprot.org/uniprotkb/Q17QP1", "locus": { "chromosome": "7", "start_pos": 5829858, "end_pos": 5822902, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025809", "url": "https://www.ensembl.org/id/ENSBTAG00000025809" } ] } } ], "crossref": [ { "id": "Q17QP1", "url": "https://alphafold.ebi.ac.uk/entry/Q17QP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025809", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025809", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768306", "url": "https://www.ncbi.nlm.nih.gov/gene/768306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768306", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VHCQRRI", "url": "https://omabrowser.org/oma/group/VHCQRRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QP1", "url": "https://www.orthodb.org/?gene=Q17QP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42886", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42886", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42886:SF83", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42886:SF83", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071591", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QP1-1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTGVTDGIFCCLLGAPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAPTPPPPLSDAAQGDQSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRSVPGSAGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSVFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEEKK", "length": 432, "header": "sp|Q17QP1-1|ABHD8_BOVIN Isoform 1 of Protein ABHD8 OS=Bos taurus OX=9913 GN=ABHD8 PE=2 SV=1 CANONICAL=Q17QP1-1" }, "isoforms": [ { "isoform_ac": "Q17QP1-1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1/entry#Q17QP1-1", "sequence": { "sequence": "MLTGVTDGIFCCLLGAPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAPTPPPPLSDAAQGDQSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRSVPGSAGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSVFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEEKK", "length": 432, "header": "sp|Q17QP1-1|ABHD8_BOVIN Isoform 1 of Protein ABHD8 OS=Bos taurus OX=9913 GN=ABHD8 PE=2 SV=1 CANONICAL=Q17QP1-1" }, "locus": { "chromosome": "7", "start_pos": 5829329, "end_pos": 5824222, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036501.7", "url": "https://www.ensembl.org/id/ENSBTAT00000036501.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036358.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036358.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 274, "start_aa": "Thr", "end_pos": 274, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr274", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 56, "start_aa": "Thr", "end_pos": 56, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr56", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:768306", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768306", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BM17-1", "protein_name": "Protein ABHD8", "gene_name": "ABHD8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTGVTDGIFCCLLGAPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAPTPSPPLSDTAQGDQTGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRSGTGSAGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPLEEKK", "length": 432 }, "evidence": [ { "id": "Q17QP1", "url": "https://omabrowser.org/oma/group/Q17QP1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AIY3-1", "protein_name": "Protein ABHD8", "gene_name": "Abhd8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMSLKLDSVLTREGQRTGKGKGHTMLTGVTDGFFCCLLGTPPNAVRPLESVESSDGYTFVEVKPGRVLRVKHACPAPIPSPPPPPPEDNPGVKTGLVRCQRRITVYRNGRLVVENLGRAPRADLQGRSGSGDPPGSLEVELAEPAGGDTRATPGSGRRRRPRRPKRTIHIDCEQRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFTRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIEEGSHMVMLECPETVNTLLHEFLLWEPEPEAEPKLEPKSKPQPLQLQSDPAPGEEK", "length": 459 }, "evidence": [ { "id": "Q17QP1", "url": "https://omabrowser.org/oma/group/Q17QP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AL80-1", "protein_name": "Protein ABHD8", "gene_name": "ABHD8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLNSITEGFLCCLMGKTTNAVGPLDSVESSNGYSFLEVKPGRILRVRHSAPSRPPAEPAEEPGAAERGTVHCKRKITLYRNGQLVIENLGDAVRSEILHCSNSTAEPSSTVELELSELAGQAPAQGSAGTPGCSTPGCGARDAAGGKRRKRKPKKVINIDCKKQITSCKGTHGDVVLFFIHGVGGSLDIWKEQLDFFTKLGYEVVAPDLAGHGCSSAPQIAAAYTFYALAEDMRAVFKRYAKKRNILIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELAVPVLLVHGMHDKFVPVEEDQRMAEILLIAFLKVIDEGSHMVMMECPETVNTLLHEFVLWEPETPAGDGQGEKK", "length": 431 }, "evidence": [ { "id": "Q17QP1", "url": "https://omabrowser.org/oma/group/Q17QP1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8R0P8-1", "protein_name": "Protein ABHD8", "gene_name": "Abhd8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSEHTMLTGVTDGFFCCLLGTPPNAVRPLESVESSDGYTFVEVKPGRVLRVKHAGPAPIPTPPPPPPEDDPGVKTGLVRCQRRITVYRNGRLVVENLGRAPRADLQGRSGSGDPPAALEVELAEPAGGDTRANPGSGRRRRPRRPKRTIHIDCEQRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFTRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIEEGSHMVMLECPETVNTLLHEFLLWEPEPEAEPKLEPKPKPQLLQPEPAPGEEK", "length": 439 }, "evidence": [ { "id": "Q17QP1", "url": "https://omabrowser.org/oma/group/Q17QP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96I13-1", "protein_name": "Protein ABHD8", "gene_name": "ABHD8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAAAPPPPSSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRLAPGSAGSGSGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEDKK", "length": 439 }, "evidence": [ { "id": "Q17QP1", "url": "https://omabrowser.org/oma/group/Q17QP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "phosphatidic acid biosynthetic process", "id": "GO:0006654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006654", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" }, { "name": "negative regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900226", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lysophosphatidic acid acyltransferase activity", "id": "GO:0042171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042171", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" }, { "name": "carboxylic ester hydrolase activity", "id": "GO:0052689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" }, { "name": "phospholipase activity", "id": "GO:0004620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004620", "evidence": [ { "database": "UniProtKB", "id": "Q17QP1", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 432, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QP1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17QP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP1" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AB hydrolase-1", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 272, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 56, 274 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 325, "end_pos": 327 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QP7-1", "uniprot_ac": "Q17QP7", "uniprot_id": "CLBA1_BOVIN", "mass": { "chemical_mass": 35944.0, "monoisotopic_mass": 35944.0 }, "refseq": { "ac": "NP_001069041", "name": "uncharacterized protein CLBA1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" }, "gene_names": [ { "name": "CLBA1", "type": "recommended", "evidence": [ { "id": "Q17QP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP7" } ] }, { "name": "C14orf79", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] }, { "name": "C21H14orf79", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] }, { "name": "CLBA1", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] } ], "protein_names": [ { "name": "Uncharacterized protein CLBA1", "type": "recommended", "evidence": [ { "id": "Q17QP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP7/entry#names_and_taxonomy" } ] }, { "name": "Clathrin-binding box of aftiphilin-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q17QP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QP7/entry#names_and_taxonomy" } ] }, { "name": "clathrin-binding box of aftiphilin-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] }, { "name": "uncharacterized protein C14orf79 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] }, { "name": "uncharacterized protein CLBA1", "type": "synonym", "evidence": [ { "id": "NP_001069041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QP7", "url": "https://www.uniprot.org/uniprotkb/Q17QP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLBA1", "url": "https://www.uniprot.org/uniprotkb/Q17QP7", "locus": { "chromosome": "21", "start_pos": 69409669, "end_pos": 69404441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010370", "url": "https://www.ensembl.org/id/ENSBTAG00000010370" } ] } } ], "crossref": [ { "id": "Q17QP7", "url": "https://alphafold.ebi.ac.uk/entry/Q17QP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "512628", "url": "https://www.ncbi.nlm.nih.gov/gene/512628", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029205", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029205", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512628", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512628", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QP7", "url": "https://www.orthodb.org/?gene=Q17QP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16156:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16156:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15045", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15045", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069041", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QP7", "url": "https://www.uniprot.org/uniprotkb/Q17QP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QP7-1", "url": "https://www.uniprot.org/uniprotkb/Q17QP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDQRELGGAAGQGLPLCAFLSDLPEQGGGVSLRQVSKDSGAPGRQSGDAVEWARLRCALPPPDGEARTSGGSCEGLSTSTARGPDPGEHSGAWGEFEVFQESSASSEQFCQSFELQERPAASQPWRTASAQKQHGSSQPHQGGVTGTGAIAASELVVSCEDVFRSAFQEVPVPQATEGISTLDHFLEARNEESSGLESAQKLCSESRKLWRALHNTGTMTISRCTWSESRSRENFLPVLGVDAAQKSLSGSPGRTLGEPGLHEPEELGFHLQRCRALIQTKLSGTPTGGQGSLITYSLFLKTPIHGNGQYITTPRKKKTFGPRNLKLTLFNSDIY", "length": 336, "header": "sp|Q17QP7-1|CLBA1_BOVIN Isoform 1 of Uncharacterized protein CLBA1 OS=Bos taurus OX=9913 GN=CLBA1 PE=2 SV=2 CANONICAL=Q17QP7-1" }, "isoforms": [ { "isoform_ac": "Q17QP7-1", "url": "https://www.uniprot.org/uniprotkb/Q17QP7/entry#Q17QP7-1", "sequence": { "sequence": "MQDQRELGGAAGQGLPLCAFLSDLPEQGGGVSLRQVSKDSGAPGRQSGDAVEWARLRCALPPPDGEARTSGGSCEGLSTSTARGPDPGEHSGAWGEFEVFQESSASSEQFCQSFELQERPAASQPWRTASAQKQHGSSQPHQGGVTGTGAIAASELVVSCEDVFRSAFQEVPVPQATEGISTLDHFLEARNEESSGLESAQKLCSESRKLWRALHNTGTMTISRCTWSESRSRENFLPVLGVDAAQKSLSGSPGRTLGEPGLHEPEELGFHLQRCRALIQTKLSGTPTGGQGSLITYSLFLKTPIHGNGQYITTPRKKKTFGPRNLKLTLFNSDIY", "length": 336, "header": "sp|Q17QP7-1|CLBA1_BOVIN Isoform 1 of Uncharacterized protein CLBA1 OS=Bos taurus OX=9913 GN=CLBA1 PE=2 SV=2 CANONICAL=Q17QP7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512628", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512628", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "Q17QP7", "url": "https://www.uniprot.org/uniprotkb/Q17QP7" } ], "pmid": "" }, { "name": "AP-1 adaptor complex", "id": "GO:0030121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030121", "evidence": [ { "database": "UniProtKB", "id": "Q17QP7", "url": "https://www.uniprot.org/uniprotkb/Q17QP7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "Q17QP7", "url": "https://www.uniprot.org/uniprotkb/Q17QP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 336, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QP7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QQ2-1", "uniprot_ac": "Q17QQ2", "uniprot_id": "TPMT_BOVIN", "mass": { "chemical_mass": 28335.0, "monoisotopic_mass": 28335.0 }, "refseq": { "ac": "NP_001068999", "name": "thiopurine S-methyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068999" }, "gene_names": [ { "name": "TPMT", "type": "recommended", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ] }, { "name": "TPMT", "type": "synonym", "evidence": [ { "id": "NP_001068999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068999" } ] } ], "protein_names": [ { "name": "Thiopurine S-methyltransferase", "type": "recommended", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.67", "type": "synonym", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2/entry#names_and_taxonomy" } ] }, { "name": "Thiopurine methyltransferase", "type": "synonym", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2/entry#names_and_taxonomy" } ] }, { "name": "thiopurine S-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001068999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068999" } ] }, { "name": "thiopurine methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001068999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068999" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPMT", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2", "locus": { "chromosome": "23", "start_pos": 39454935, "end_pos": 39431910, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019300", "url": "https://www.ensembl.org/id/ENSBTAG00000019300" } ] } } ], "crossref": [ { "id": "Q17QQ2", "url": "https://alphafold.ebi.ac.uk/entry/Q17QQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019300", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019300", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511644", "url": "https://www.ncbi.nlm.nih.gov/gene/511644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008854", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008854", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKWVNRN", "url": "https://omabrowser.org/oma/group/EKWVNRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QQ2", "url": "https://www.orthodb.org/?gene=Q17QQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10259", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10259", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10259:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10259:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05724", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05724", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156581", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156581", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9748787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068999", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSRALLDSEEYPNTEAQKDRVLTLEEWQEKWVNHKTGFHQEQGHQLLKKYLDTFLKGEKALRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIRDFFTEQNLSYSEEPIMEIPGAKIFKSSSGNISLYCCNLFDLPRANIGKFDRIWDRGALVAVNPSDRKRYSDVMLSLTRPGFRYLLSVFSYDPTKHAGPPFYVTDGEVKKLFGSVCNIQCLEKVDVFEERHKSWGIDQIIERLYLFTEK", "length": 245, "header": "sp|Q17QQ2-1|TPMT_BOVIN Isoform 1 of Thiopurine S-methyltransferase OS=Bos taurus OX=9913 GN=TPMT PE=2 SV=1 CANONICAL=Q17QQ2-1" }, "isoforms": [ { "isoform_ac": "Q17QQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2/entry#Q17QQ2-1", "sequence": { "sequence": "MGDSRALLDSEEYPNTEAQKDRVLTLEEWQEKWVNHKTGFHQEQGHQLLKKYLDTFLKGEKALRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIRDFFTEQNLSYSEEPIMEIPGAKIFKSSSGNISLYCCNLFDLPRANIGKFDRIWDRGALVAVNPSDRKRYSDVMLSLTRPGFRYLLSVFSYDPTKHAGPPFYVTDGEVKKLFGSVCNIQCLEKVDVFEERHKSWGIDQIIERLYLFTEK", "length": 245, "header": "sp|Q17QQ2-1|TPMT_BOVIN Isoform 1 of Thiopurine S-methyltransferase OS=Bos taurus OX=9913 GN=TPMT PE=2 SV=1 CANONICAL=Q17QQ2-1" }, "locus": { "chromosome": "23", "start_pos": 39454344, "end_pos": 39438122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025698.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025698.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025698.2", "url": "https://www.ensembl.org/id/ENSBTAP00000025698.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511644", "resource": "KEGG Pathway" }, { "id": "R-BTA-156581", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156581", "resource": "Reactome", "description": "Methylation" }, { "id": "R-BTA-9748787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "resource": "Reactome", "description": "Azathioprine ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LC84-1", "protein_name": "Thiopurine S-methyltransferase", "gene_name": "Tpmt", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDATTPLDVKEHFDAEVQKNRVLSLEEWESKWVTRNIGFHQEQGHQLLKKHLDTFLKGQSGLRVLFPLCGKAVEMKWFAERGHTVVGVEISEIGIREFFAEQNLPYTEEPFNEIPGAKVFKSSSGNISLYCCSIFDLPRANIGKFDRIWDRGSLVAINPGDRERYADIILSLLRKGFQYLVAILSYDPTKHAGPPFYVPDAELKRLFGSKCSIRCLEEVDAFEERHKAWGIGSLFEKLYLLTEK", "length": 244 }, "evidence": [ { "id": "Q17QQ2", "url": "https://omabrowser.org/oma/group/Q17QQ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RUH7-1", "protein_name": "Thiopurine S-methyltransferase", "gene_name": "TPMT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNDPRTVLDVDEYPDTEAQKNRMLTLEEWQEKWVNRNISFHQERGHQLLKKHLDTFLKDEKGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIREFFTEQDLSYSEEPIAEIPGAKVFKSSSGNISLYCCNLFDLPRVNIGKFDRIWDRGAFVAVNPGDRKRYADVMLSLTRTGFQYFLCVLAYDPTKHAGPPFYVPDAEIERLFGSICNIHCLEKVDVFEERHKSWGIDYIIEKLYLFTEK", "length": 245 }, "evidence": [ { "id": "Q17QQ2", "url": "https://omabrowser.org/oma/group/Q17QQ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O55060-1", "protein_name": "Thiopurine S-methyltransferase", "gene_name": "Tpmt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLDMKEHPDAEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLAEIAGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDHDRYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCSMQCLEEVDALEERHKAWGLDYLFEKLYLLTEK", "length": 240 }, "evidence": [ { "id": "Q17QQ2", "url": "https://omabrowser.org/oma/group/Q17QQ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thiopurine S-methyltransferase activity", "id": "GO:0008119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008119", "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "pmid": "" }, { "name": "S-adenosyl-L-methionine binding", "id": "GO:1904047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047", "evidence": [ { "database": "UniProtKB", "id": "Q17QQ2", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-158609", "name": "TPMT transfers CH3 from AdoMet to 6MP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-158619" ], "output_participant_list": [ "R-ALL-158611" ], "enzyme_list": [ "Q17QQ2-1" ], "evidence": [ { "id": "R-BTA-158609", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-158609" } ] }, { "id": "R-BTA-9748979", "name": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9748992" ], "output_participant_list": [ "R-ALL-9748944" ], "enzyme_list": [ "Q17QQ2-1" ], "evidence": [ { "id": "R-BTA-9748979", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748979" } ] }, { "id": "R-BTA-9748983", "name": "TPMT transfers methyl group to 6MP, forming 6MeMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9748998" ], "output_participant_list": [ "R-ALL-9748982" ], "enzyme_list": [ "Q17QQ2-1" ], "evidence": [ { "id": "R-BTA-9748983", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748983" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-158611", "participant_name": "6MMP [cytosol]", "crossref": [ { "id": "28279", "database": "ChEBI", "url": "" }, { "id": "ZINC000018113502", "database": "ZINC", "url": "" }, { "id": "HMDB0060412", "database": "HMDB Metabolite", "url": "" }, { "id": "8144367", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-158619", "participant_name": "6MP [cytosol]", "crossref": [ { "id": "2208", "database": "ChEBI", "url": "" }, { "id": "C02380", "database": "COMPOUND", "url": "" }, { "id": "8148223", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000004658290", "database": "ZINC", "url": "" }, { "id": "HMDB0015167", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-9748944", "participant_name": "6MeTIMP [cytosol]", "crossref": [ { "id": "3037883", "database": "PubChem Compound", "url": "" } ] }, { "participant_id": "R-ALL-9748982", "participant_name": "6MeMP [cytosol]", "crossref": [ { "id": "ZINC000018113502", "database": "ZINC", "url": "" }, { "id": "28279", "database": "ChEBI", "url": "" }, { "id": "HMDB0060412", "database": "HMDB Metabolite", "url": "" }, { "id": "8144367", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-9748992", "participant_name": "6TIMP [cytosol]", "crossref": [ { "id": "180684", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9748998", "participant_name": "6MP [cytosol]", "crossref": [ { "id": "7226", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "2208", "database": "ChEBI", "url": "" }, { "id": "94796", "database": "ChEBI", "url": "" }, { "id": "50667", "database": "ChEBI", "url": "" }, { "id": "PDBC00164", "database": "PharmacoDB", "url": "" }, { "id": "0005101", "database": "Mondo", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q17QQ2", "gene_name": "TPMT", "activity": [ { "ec_number": "2.1.1.67", "activity": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ] }, { "ec_number": "2.1.1.67", "activity": "", "evidence": [ { "id": "Q17QQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QQ2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QQ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 245, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QQ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QQ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.67", "ec_name": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.67", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.67" }, { "id": "2.1.1.67", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.67" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QR4-1", "uniprot_ac": "Q17QR4", "uniprot_id": "CC137_BOVIN", "mass": { "chemical_mass": 33517.0, "monoisotopic_mass": 33517.0 }, "refseq": { "ac": "NP_001068969", "name": "coiled-coil domain-containing protein 137", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068969" }, "gene_names": [ { "name": "CCDC137", "type": "recommended", "evidence": [ { "id": "Q17QR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ] }, { "name": "CCDC137", "type": "synonym", "evidence": [ { "id": "NP_001068969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068969" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 137", "type": "recommended", "evidence": [ { "id": "Q17QR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QR4/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 137", "type": "synonym", "evidence": [ { "id": "NP_001068969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068969" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC137", "url": "https://www.uniprot.org/uniprotkb/Q17QR4", "locus": { "chromosome": "19", "start_pos": 51148536, "end_pos": 51154185, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000356", "url": "https://www.ensembl.org/id/ENSBTAG00000000356" } ] } } ], "crossref": [ { "id": "Q17QR4", "url": "https://alphafold.ebi.ac.uk/entry/Q17QR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000356", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000356", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511225", "url": "https://www.ncbi.nlm.nih.gov/gene/511225", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511225", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511225", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHGVRDP", "url": "https://omabrowser.org/oma/group/HHGVRDP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QR4", "url": "https://www.orthodb.org/?gene=Q17QR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21838", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21838", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21838:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21838:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068969", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QR4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLRRGAAAVAPAGTAGFGRPGRPQGRRQQELGKQRAAPRPGPRSKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKNPISNKKRKKEAQAAFSKTLEKEAKGVEPDIAIPKFKQRKWESDRAYVRRMEQEAQHVLFLSKNQANRQPEVQAAPKKEKSERKKAFQKRRLDKARQRREEKAAERLEQELLQDTVKFGEVVLQPPELTAKPRMSVSRDQPGKKSLMLKKLLSPGSVSQPLTTSLARQRIVAEERERAVNAYRALKRLQQQRQETQSPQPPHLPPGKKPEMQL", "length": 292, "header": "sp|Q17QR4-1|CC137_BOVIN Isoform 1 of Coiled-coil domain-containing protein 137 OS=Bos taurus OX=9913 GN=CCDC137 PE=2 SV=1 CANONICAL=Q17QR4-1" }, "isoforms": [ { "isoform_ac": "Q17QR4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QR4/entry#Q17QR4-1", "sequence": { "sequence": "MAGLRRGAAAVAPAGTAGFGRPGRPQGRRQQELGKQRAAPRPGPRSKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKNPISNKKRKKEAQAAFSKTLEKEAKGVEPDIAIPKFKQRKWESDRAYVRRMEQEAQHVLFLSKNQANRQPEVQAAPKKEKSERKKAFQKRRLDKARQRREEKAAERLEQELLQDTVKFGEVVLQPPELTAKPRMSVSRDQPGKKSLMLKKLLSPGSVSQPLTTSLARQRIVAEERERAVNAYRALKRLQQQRQETQSPQPPHLPPGKKPEMQL", "length": 292, "header": "sp|Q17QR4-1|CC137_BOVIN Isoform 1 of Coiled-coil domain-containing protein 137 OS=Bos taurus OX=9913 GN=CCDC137 PE=2 SV=1 CANONICAL=Q17QR4-1" }, "locus": { "chromosome": "19", "start_pos": 51154127, "end_pos": 51149647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034734.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034734.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034619.2", "url": "https://www.ensembl.org/id/ENSBTAP00000034619.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "site_lbl": "Ser232" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511225", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511225", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BKK7-1", "protein_name": "Coiled-coil domain containing 137", "gene_name": "CCDC137", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGVGSRAAAPAGTAGPGRPGRPRGRRQRQPGKQRSAPQPGLHSKEKKKVNCKPKNRDEQEIPFRLREIMRSRQEMKNPISNKKRKKEAQVAFRRTLEKEAKGVESDIAVPKFKQRKWESDGAYVRRMEQEAQHVLFLSKNQASRQPEAQAAPRKEKSERKKAFQKRRLEKVRRRREEAAAERLEQELLRDTVEFGEVALQPPELTAKPRTSGSGGQPGKKPLMLKMLLSSGGVSQPPATSLARRRIVQEERERAVQAYRALKKLQQQQRLGTQSPRPPRPEPGKKPQTRV", "length": 291 }, "evidence": [ { "id": "Q17QR4", "url": "https://omabrowser.org/oma/group/Q17QR4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PK04-1", "protein_name": "Coiled-coil domain-containing protein 137", "gene_name": "CCDC137", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAGRGAAVSRVQAGPGSPRRARGRQQVQPLGKQRPAPWPGLRSKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKNPISNKKRKKAAQVTFRKTLEKEAKGEEPDIAVPKFKQRKGESDGAYIHRMQQEAQHVLFLSKNQAIRQPEVQAAPKEKSEQKKAKKAFQKRRLDKVRRKKEEKAADRLEQELLRDTVKFGEVVLQPPELTARPQRSVSKDQPGRRSQMLRMLLSPGGVSQPLTASLARQRIVEEERERAVQAYRALKQRQQQLHGERPHLTSRKKPEPQL", "length": 289 }, "evidence": [ { "id": "Q17QR4", "url": "https://omabrowser.org/oma/group/Q17QR4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R0K4-1", "protein_name": "Coiled-coil domain-containing protein 137", "gene_name": "Ccdc137", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARPGNIALVTARSAGLRGSGQPQGRRQQQAQGQQRSASLPGQRSKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKKTLSNKKRKKEAQVAFKKTLEKEAKGEEPDIAVPKFKQRKGESDVAYVQRMEQEAQHVLFLSKNQAPRQPEVQAAPKKEKSERKKAFQKRRLEKAQRKREARAVDRLEQELLKDTVKFGEVVLQPPELTVQPRRSTSRDAPGKKSLMLKKMLLGPGGGSPAPATSLARQRILGEERERAVQAYRALKKLHRQEMTPAQPPGSSFQRQGHACL", "length": 290 }, "evidence": [ { "id": "Q17QR4", "url": "https://omabrowser.org/oma/group/Q17QR4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q17QR4", "url": "https://www.uniprot.org/uniprotkb/Q17QR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QR4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QR4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QR4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 232 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QS0-1", "uniprot_ac": "Q17QS0", "uniprot_id": "SCRN3_BOVIN", "mass": { "chemical_mass": 48234.0, "monoisotopic_mass": 48234.0 }, "refseq": { "ac": "NP_001069015", "name": "secernin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069015" }, "gene_names": [ { "name": "SCRN3", "type": "recommended", "evidence": [ { "id": "Q17QS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ] }, { "name": "SCRN3", "type": "synonym", "evidence": [ { "id": "NP_001069015", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069015" } ] } ], "protein_names": [ { "name": "Secernin-3", "type": "recommended", "evidence": [ { "id": "Q17QS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QS0/entry#names_and_taxonomy" } ] }, { "name": "secernin-3", "type": "synonym", "evidence": [ { "id": "NP_001069015", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069015" } ] } ], "function": [ { "annotation": "Plays a role in thermal nociception.", "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0#function" }, { "database": "UniProtKB", "id": "Q3TMH2", "url": "https://www.uniprot.org/uniprotkb/Q3TMH2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCRN3", "url": "https://www.uniprot.org/uniprotkb/Q17QS0", "locus": { "chromosome": "2", "start_pos": 22365327, "end_pos": 22397619, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012966", "url": "https://www.ensembl.org/id/ENSBTAG00000012966" } ] } } ], "crossref": [ { "id": "Q17QS0", "url": "https://alphafold.ebi.ac.uk/entry/Q17QS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "511983", "url": "https://www.ncbi.nlm.nih.gov/gene/511983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511983", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QS0", "url": "https://www.orthodb.org/?gene=Q17QS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12994:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12994:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03577", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03577", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069015", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QS0-1", "url": "https://www.uniprot.org/uniprotkb/Q17QS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSIMTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTEKAKTMLDNMRKLEKELFKEMESVLQNKHLQVDKIVNLLHQCTEDEIRIYKSNVSS", "length": 422, "header": "sp|Q17QS0-1|SCRN3_BOVIN Isoform 1 of Secernin-3 OS=Bos taurus OX=9913 GN=SCRN3 PE=2 SV=1 CANONICAL=Q17QS0-1" }, "isoforms": [ { "isoform_ac": "Q17QS0-1", "url": "https://www.uniprot.org/uniprotkb/Q17QS0/entry#Q17QS0-1", "sequence": { "sequence": "MEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSIMTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTEKAKTMLDNMRKLEKELFKEMESVLQNKHLQVDKIVNLLHQCTEDEIRIYKSNVSS", "length": 422, "header": "sp|Q17QS0-1|SCRN3_BOVIN Isoform 1 of Secernin-3 OS=Bos taurus OX=9913 GN=SCRN3 PE=2 SV=1 CANONICAL=Q17QS0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "41018975", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/41018975" }, { "id": "Q17QS0", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q17QS0" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Epigenetic co-regulator HCF-1 promotes lung cancer via O-GlcNAcylation-dependent pathways.", "journal": "Molecular therapy. Oncology", "date": "2025-12-18", "authors": "Srivastava Priyanka P, Dasari Abhilash, Kumar Saran, Gupta Ishaan, Jain Deepali, Minocha Shilpi", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q17QS0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q17QS0" } ], "reference": [ { "type": "PubMed", "id": "41018975", "url": "https://glygen.org/publication/PubMed/41018975" } ] } ], "pathway": [ { "id": "bta:511983", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511983", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ], "pmid": "" }, { "name": "detection of temperature stimulus involved in sensory perception of pain", "id": "GO:0050965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050965", "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dipeptidase activity", "id": "GO:0016805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016805", "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ], "pmid": "" }, { "name": "cysteine-type exopeptidase activity", "id": "GO:0070004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070004", "evidence": [ { "database": "UniProtKB", "id": "Q17QS0", "url": "https://www.uniprot.org/uniprotkb/Q17QS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QS0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 422, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QS0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QS0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 419, "end_pos": 421 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q17QT4-1", "uniprot_ac": "Q17QT4", "uniprot_id": "RUSD1_BOVIN", "mass": { "chemical_mass": 34177.0, "monoisotopic_mass": 34177.0 }, "refseq": { "ac": "NP_001069342", "name": "RNA pseudouridylate synthase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069342" }, "gene_names": [ { "name": "RPUSD1", "type": "recommended", "evidence": [ { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ] }, { "name": "RPUSD1", "type": "synonym", "evidence": [ { "id": "NP_001069342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069342" } ] } ], "protein_names": [ { "name": "Pseudouridylate synthase RPUSD1", "type": "recommended", "evidence": [ { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.-", "type": "synonym", "evidence": [ { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4/entry#names_and_taxonomy" } ] }, { "name": "RNA pseudouridylate synthase domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001069342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069342" } ] }, { "name": "RNA pseudouridylate synthase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069342" }, { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal large subunit pseudouridine synthase C-like protein", "type": "synonym", "evidence": [ { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pseudouridylate synthase that catalyzes the conversion of uridine to pseudouridine in cytoplasmic tRNAs. Catalyzes pseudouridylation of pseudouridine-30 and pseudouridine-72 from uracil-30 and uracil-72 within the anticodon stem of cytoplasmic tRNAs.", "evidence": [ { "database": "UniProtKB", "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4#function" }, { "database": "UniProtKB", "id": "Q9UJJ7", "url": "https://www.uniprot.org/uniprotkb/Q9UJJ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPUSD1", "url": "https://www.uniprot.org/uniprotkb/Q17QT4", "locus": { "chromosome": "25", "start_pos": 665460, "end_pos": 669345, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000179", "url": "https://www.ensembl.org/id/ENSBTAG00000000179" } ] } } ], "crossref": [ { "id": "Q17QT4", "url": "https://alphafold.ebi.ac.uk/entry/Q17QT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000179", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000179", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02869", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02869", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525521", "url": "https://www.ncbi.nlm.nih.gov/gene/525521", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525521", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525521", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGTSGIM", "url": "https://omabrowser.org/oma/group/FGTSGIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QT4", "url": "https://www.orthodb.org/?gene=Q17QT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00849", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00849", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069342", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54572", "url": "https://www.rhea-db.org/rhea/54572", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QT4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPGSVENLCVVYRSHDFLVVNKHWDVRIDSKAWRETLTLQKQLRHRFPELADPDTYYGFRFCHQLDFSTSGALCVALNKAAAGSAYRCFKDRRVTKAYLALVRGHVQESRMTISYAIGKNSTEGRTHTMCIEGTQGCENPKPSLTELVVLEHGLYAGDPVSKVLLQPLTGRTHQLRVHCSALGHPIVGDLTYGHALGQEDQPFRMMLHAFYLRIPTSAECVEACTPDPFVPSLDACWSPHTLLQPLDELVQVLRAAPDPDPSEGGPGPCSPCTPLPGPGRPPPPPETEVQRASCLQWLSEWTLEPDN", "length": 308, "header": "sp|Q17QT4-1|RUSD1_BOVIN Isoform 1 of Pseudouridylate synthase RPUSD1 OS=Bos taurus OX=9913 GN=RPUSD1 PE=2 SV=1 CANONICAL=Q17QT4-1" }, "isoforms": [ { "isoform_ac": "Q17QT4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QT4/entry#Q17QT4-1", "sequence": { "sequence": "MEPGSVENLCVVYRSHDFLVVNKHWDVRIDSKAWRETLTLQKQLRHRFPELADPDTYYGFRFCHQLDFSTSGALCVALNKAAAGSAYRCFKDRRVTKAYLALVRGHVQESRMTISYAIGKNSTEGRTHTMCIEGTQGCENPKPSLTELVVLEHGLYAGDPVSKVLLQPLTGRTHQLRVHCSALGHPIVGDLTYGHALGQEDQPFRMMLHAFYLRIPTSAECVEACTPDPFVPSLDACWSPHTLLQPLDELVQVLRAAPDPDPSEGGPGPCSPCTPLPGPGRPPPPPETEVQRASCLQWLSEWTLEPDN", "length": 308, "header": "sp|Q17QT4-1|RUSD1_BOVIN Isoform 1 of Pseudouridylate synthase RPUSD1 OS=Bos taurus OX=9913 GN=RPUSD1 PE=2 SV=1 CANONICAL=Q17QT4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:525521", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525521", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HBV3-1", "protein_name": "RNA pseudouridylate synthase domain-containing protein 1", "gene_name": "Rpusd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPGSMENLSIVYQSSDFLVVNKHWDLRIDSKTWQETLTLQKQLCHRFPELADPDTCYGFRFCHQLDFSTSGALCVALNKAAAGSAYKCFKERRVTKAYLALVRGHVQKSQVTISYAIGRNSTEGRTHTMCIEGTHGCENPKPSLTELLVLEHGQYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPIVGDLTYGQAEDQEDQPFRMMLHAFYLRIPTQAECVEACTPDPFLPALDACWSPHTCIQPLEELIQALQTGPDPNPVDGGHSPSTPLARPGRPPPETEAQRASCLQWLSEWALEPDN", "length": 303 }, "evidence": [ { "id": "Q17QT4", "url": "https://omabrowser.org/oma/group/Q17QT4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "enzyme-directed rRNA pseudouridine synthesis", "id": "GO:0000455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000455", "evidence": [ { "database": "UniProtKB", "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "Q17QT4", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54572", "name": "", "equation": "a uridine in tRNA = a pseudouridine in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "E1BDL3-1", "A0AAA9TCW3-1", "A0AAA9T9C6-1", "Q17QT4-1" ], "evidence": [ { "id": "54572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54572" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T9C6", "gene_name": "TRUB1", "activity": [ { "ec_number": "5.4.99.25", "activity": "uridine(55) in tRNA = pseudouridine(55) in tRNA.", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ] }, { "ec_number": "5.4.99.25", "activity": "", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ] } ] }, { "uniprot_ac": "A0AAA9TCW3", "gene_name": "PUSL1", "activity": [ { "ec_number": "5.4.99.12", "activity": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA.", "evidence": [ { "id": "A0AAA9TCW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW3" } ] }, { "ec_number": "5.4.99.12", "activity": "", "evidence": [ { "id": "A0AAA9TCW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW3" } ] } ] }, { "uniprot_ac": "E1BDL3", "gene_name": "PUS1", "activity": [ { "ec_number": "5.4.99.12", "activity": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA.", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ] }, { "ec_number": "5.4.99.12", "activity": "", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ] } ] }, { "uniprot_ac": "Q08DI8", "gene_name": "PUS7", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q08DI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI8" } ] } ] }, { "uniprot_ac": "Q17QT4", "gene_name": "RPUSD1", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q17QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QT4" } ] } ] }, { "uniprot_ac": "Q5E9Z1", "gene_name": "RPUSD4", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q5E9Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QT4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QT4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QT4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QU3-1", "uniprot_ac": "Q17QU3", "uniprot_id": "ARPIN_BOVIN", "mass": { "chemical_mass": 24886.0, "monoisotopic_mass": 24886.0 }, "refseq": { "ac": "NP_001069772", "name": "arpin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772" }, "gene_names": [ { "name": "ARPIN", "type": "recommended", "evidence": [ { "id": "Q17QU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ] }, { "name": "ARPIN", "type": "synonym", "evidence": [ { "id": "NP_001069772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772" } ] }, { "name": "C21H15orf38", "type": "synonym", "evidence": [ { "id": "NP_001069772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772" } ] } ], "protein_names": [ { "name": "Arpin", "type": "recommended", "evidence": [ { "id": "Q17QU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU3/entry#names_and_taxonomy" } ] }, { "name": "UPF0552 protein C15orf38 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772" } ] }, { "name": "arpin", "type": "synonym", "evidence": [ { "id": "NP_001069772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772" } ] } ], "function": [ { "annotation": "Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARPIN", "url": "https://www.uniprot.org/uniprotkb/Q17QU3", "locus": { "chromosome": "21", "start_pos": 21299134, "end_pos": 21307822, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027059", "url": "https://www.ensembl.org/id/ENSBTAG00000027059" } ] } } ], "crossref": [ { "id": "Q17QU3", "url": "https://alphafold.ebi.ac.uk/entry/Q17QU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027059", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027059", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613997", "url": "https://www.ncbi.nlm.nih.gov/gene/613997", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613997", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613997", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QTVAFWI", "url": "https://omabrowser.org/oma/group/QTVAFWI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QU3", "url": "https://www.orthodb.org/?gene=Q17QU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31199:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31199:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N203", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N203", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N203-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N203-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QU3-1", "url": "https://www.uniprot.org/uniprotkb/Q17QU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRIYQDSALRNKAVRSARLPGAWDPAAHQRGDGVLLEGELLDVSRHSILDAHGRKERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDSDRLTPEALKGLVNKPELLALTESLTPAETVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSSEGAASETREQGDGAADEEWDD", "length": 226, "header": "sp|Q17QU3-1|ARPIN_BOVIN Isoform 1 of Arpin OS=Bos taurus OX=9913 GN=ARPIN PE=2 SV=1 CANONICAL=Q17QU3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N203-1", "url": "https://www.uniprot.org/uniprotkb/Q17QU3/entry#A0A3Q1N203-1", "sequence": { "sequence": "MSRIYQDSALRNKAVRSARLPGAWDPAAHQRGDGVLLEGELLDVSRHSILDAHGRKERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDSDRLTPEALKGLVNKPELLALTESLTPAETVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSSEGAASETREQGDGAADEDEPLFDDNRRRL", "length": 234, "header": "tr|A0A3Q1N203-1|A0A3Q1N203_BOVIN Computationally mapped isoform of Arpin OS=Bos taurus OX=9913 GN=ARPIN PE=3 SV=1 CANONICAL=Q17QU3-1" }, "locus": { "chromosome": "21", "start_pos": 21307506, "end_pos": 21299960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078538.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078538.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063213.1" } ] } }, { "isoform_ac": "A0AAA9TXS5-1", "url": "https://www.uniprot.org/uniprotkb/Q17QU3/entry#A0AAA9TXS5-1", "sequence": { "sequence": "AASIRTAPSATRRCGARGCRGPGTLPLTSGRLRPRLSTASRPGLCRLASICFESRLPDCARGLGWGWRHRDGVRVGGKAGLAEDLRGLGIVSHSAPLGSHPRDTDPREAHGRGDGVLLEGELLDVSRHSILDAHGRKERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDSDRLTPEALKGLVNKPELLALTESLTPAETVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSSEGAASETREQGDGAADEEWDD", "length": 307, "header": "tr|A0AAA9TXS5-1|A0AAA9TXS5_BOVIN Computationally mapped isoform of Arpin OS=Bos taurus OX=9913 GN=ARPIN PE=3 SV=1 CANONICAL=Q17QU3-1" }, "locus": { "chromosome": "21", "start_pos": 21307502, "end_pos": 21299919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102287.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102287.1" } ] } }, { "isoform_ac": "A0AAF6ZD73-1", "url": "https://www.uniprot.org/uniprotkb/Q17QU3/entry#A0AAF6ZD73-1", "sequence": { "sequence": "DPSPVLPEAHFPPSKVLRQEWGSAPLNPARERPGPGRAARDRPSGIAGLRASSGSFPSRCPQPRVPTRFAIPRGRRGRGEDEPHLSGQRPPQQGGAERAAAGGLGPCRSPARRWRPAGGRITGCIPAQHLGCPRQEELSSASSRGLRLPGASFSPTPLVNRFSFQLSTSFRPGDALLHPPFLSTRVSRERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDSDRLTPEALKGLVNKPELLALTESLTPAETVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSSEGAASETREQGDGAADEEWDD", "length": 358, "header": "tr|A0AAF6ZD73-1|A0AAF6ZD73_BOVIN Computationally mapped isoform of Arpin OS=Bos taurus OX=9913 GN=ARPIN PE=3 SV=1 CANONICAL=Q17QU3-1" }, "locus": { "chromosome": "21", "start_pos": 21307747, "end_pos": 21299919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038770.4", "url": "https://www.ensembl.org/id/ENSBTAT00000038770.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038580.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038580.3" } ] } }, { "isoform_ac": "Q17QU3-1", "url": "https://www.uniprot.org/uniprotkb/Q17QU3/entry#Q17QU3-1", "sequence": { "sequence": "MSRIYQDSALRNKAVRSARLPGAWDPAAHQRGDGVLLEGELLDVSRHSILDAHGRKERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDSDRLTPEALKGLVNKPELLALTESLTPAETVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSSEGAASETREQGDGAADEEWDD", "length": 226, "header": "sp|Q17QU3-1|ARPIN_BOVIN Isoform 1 of Arpin OS=Bos taurus OX=9913 GN=ARPIN PE=2 SV=1 CANONICAL=Q17QU3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613997", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613997", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B5T1-1", "protein_name": "Arpin", "gene_name": "ARPIN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRIYHDSALQNKAVQSARLPGAWDPAAHQGGDGVLLEGELVDVSRHSISDAHGRKERYYVLYIRPSRIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDSLSPEALKGLVNKPELLALTESLTPDQTVAFWMPESEMEAMELEIGAGVRLKTRGDGPFLESLAKLEAGTVTKCNFAGDGKTGASWTDNIMAQKSWEGAAAETRGQGDGAEDEEWDD", "length": 226 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A1B2-1", "protein_name": "Arpin", "gene_name": "Arpin", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRIYHDSALRNKAVQSVRLPGTWDPTTHQGGSGVLLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSFKVEAKGDTDRLTLEVLKGLVNKPELLELTESLTPDQTVAFWMPESEMEVMELELGTGVRLKTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEWDD", "length": 226 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q1LWJ6-1", "protein_name": "Arpin", "gene_name": "arpin", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSRIYDNTALLNKPVHNEKLSFTWDPIVHQSGHGVILEGTVVDFSRHAITDVKNRKERYNVLYIKPSRVHRRKYDSKGNEIEPNFSDTKKVNTGFLMSSYKVEAKGETDCLDERQLREIVNKEQLVKVTIKHCPREAFAFWISEAEMDKTELEPGQEVRLKTKGDGPFIFSFAKLDSGTVTKCNFAGDENAGASWTEKIMANKSNQENTGKSAAQGEGADDDEWDD", "length": 226 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54F87-1", "protein_name": "Arpin", "gene_name": "arpin", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSSTNYSGTFTKERFCGGDGFIVEGILQKHNIHTVFLQAKQPLQDTVLPTRYVAITIEFDNAVKRNWKDGVEIPPKMTRATAITKGYLNKFDRVQATLVDKINADQLSVAISDGNKNSSLPSNFHDDAIKNLHPNKKNYFEFWADVDKFSHKIFKSGDEVRIKTIGDSIFVDSVVKMDSNNIANFSGDSNLGDSFASNIMKRYDQIESNNQQQQEEEDDDEWK", "length": 224 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7Z6K5-1", "protein_name": "Arpin", "gene_name": "ARPIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD", "length": 226 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D0A3-1", "protein_name": "Arpin", "gene_name": "Arpin", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRLKTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEWDD", "length": 226 }, "evidence": [ { "id": "Q17QU3", "url": "https://omabrowser.org/oma/group/Q17QU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "pmid": "" }, { "name": "directional locomotion", "id": "GO:0033058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033058", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "pmid": "" }, { "name": "negative regulation of actin nucleation", "id": "GO:0051126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051126", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "pmid": "" }, { "name": "negative regulation of lamellipodium morphogenesis", "id": "GO:2000393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000393", "evidence": [ { "database": "UniProtKB", "id": "Q17QU3", "url": "https://www.uniprot.org/uniprotkb/Q17QU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QU3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QW0-1", "uniprot_ac": "Q17QW0", "uniprot_id": "DJC22_BOVIN", "mass": { "chemical_mass": 39014.0, "monoisotopic_mass": 39014.0 }, "refseq": { "ac": "NP_001069169", "name": "dnaJ homolog subfamily C member 22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069169" }, "gene_names": [ { "name": "DNAJC22", "type": "recommended", "evidence": [ { "id": "Q17QW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW0" } ] }, { "name": "DNAJC22", "type": "synonym", "evidence": [ { "id": "NP_001069169", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069169" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 22", "type": "recommended", "evidence": [ { "id": "Q17QW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW0/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 22", "type": "synonym", "evidence": [ { "id": "NP_001069169", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069169" } ] }, { "name": "dnaJ homolog subfamily C member 22", "type": "synonym", "evidence": [ { "id": "NP_001069169", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069169" } ] } ], "function": [ { "annotation": "May function as a co-chaperone.", "evidence": [ { "database": "UniProtKB", "id": "Q17QW0", "url": "https://www.uniprot.org/uniprotkb/Q17QW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QW0", "url": "https://www.uniprot.org/uniprotkb/Q17QW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC22", "url": "https://www.uniprot.org/uniprotkb/Q17QW0", "locus": { "chromosome": "5", "start_pos": 30467093, "end_pos": 30474006, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016398", "url": "https://www.ensembl.org/id/ENSBTAG00000016398" } ] } } ], "crossref": [ { "id": "Q17QW0", "url": "https://alphafold.ebi.ac.uk/entry/Q17QW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016398", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016398", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515215", "url": "https://www.ncbi.nlm.nih.gov/gene/515215", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515215", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515215", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VWWHCLL", "url": "https://omabrowser.org/oma/group/VWWHCLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QW0", "url": "https://www.orthodb.org/?gene=Q17QW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44733", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44733", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44733:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44733:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069169", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QW0", "url": "https://www.uniprot.org/uniprotkb/Q17QW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QW0-1", "url": "https://www.uniprot.org/uniprotkb/Q17QW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QW0-2", "url": "https://www.uniprot.org/uniprotkb/Q17QW0-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVFGLSEGATNEEIHGRYRELVKTWHPDHNRYQMEEAQRRFLEIQAAYEVLRQPRKPRGSWRWEETSF", "length": 347, "header": "sp|Q17QW0-1|DJC22_BOVIN Isoform 1 of DnaJ homolog subfamily C member 22 OS=Bos taurus OX=9913 GN=DNAJC22 PE=2 SV=2 CANONICAL=Q17QW0-1" }, "isoforms": [ { "isoform_ac": "Q17QW0-1", "url": "https://www.uniprot.org/uniprotkb/Q17QW0/entry#Q17QW0-1", "sequence": { "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVFGLSEGATNEEIHGRYRELVKTWHPDHNRYQMEEAQRRFLEIQAAYEVLRQPRKPRGSWRWEETSF", "length": 347, "header": "sp|Q17QW0-1|DJC22_BOVIN Isoform 1 of DnaJ homolog subfamily C member 22 OS=Bos taurus OX=9913 GN=DNAJC22 PE=2 SV=2 CANONICAL=Q17QW0-1" }, "locus": {} }, { "isoform_ac": "Q17QW0-2", "url": "https://www.uniprot.org/uniprotkb/Q17QW0/entry#Q17QW0-2", "sequence": { "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVRFLPSHCCLRWLQKLD", "length": 297, "header": "sp|Q17QW0-2|DJC22_BOVIN Isoform 2 of DnaJ homolog subfamily C member 22 OS=Bos taurus OX=9913 GN=DNAJC22 PE=2 SV=2 CANONICAL=Q17QW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515215", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515215", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E7F2F5-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "dnajc22", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKKLMITYALWAMGGPLGLHHIYLGRDSHALLWILTFGGFGIGWAREFFRIPSYVSEANRDVEKGRVRHPGATPPPPVGLIRFVGQICVGVYFGSVALISLSSLSFFYFLVLPLSVAAGVHLVSSVGQQTSNLHKTLITCVITSSIFYGSNLSPLPISIAGSVTSAQHNTLKPLRPEPLGPRLYRLSLGVLAFSAPLGYCVFHNTTATLYYISDCIAALIDFFWFFPWLKGVLEYFLLLPYRLLCLLTGGGFYEESWRKMLEIILNEFSKKEMEALKILSLPEEASLEEITRSYRELAKVWHPDHNPKRQEEAQQMFIQIQEAYEILVDRHKTKRRK", "length": 338 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SHB7-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "DNAJC22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKGLLMTYALWAIGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWKLPSFVAQANRAQGQRQSSGRGTPPLSPIRFAAQMIVGIYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDFKHTLGVAFLISPIFYGRPIAILPISLAASITAQKHRRYKTSTGSETLSVRLYRLGLAYLAFTGPLAYSALCNTATTLSYVAETLGSFLSWFSFFPLLGHLMESVLLLPYRVWSLLVGDYGFSSGYFQEWEKLYEFVQSFQDEKRQLAYQVLGLAEGATNEEIHHRYRELVKIWHPDHNRHQPEEAQRHFLEIQAAYEVLSQPRKPRGSWRLNTALFKEAL", "length": 351 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5PR00-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "Dnajc22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKGLLMTYALWAFGGPVGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWKLPSFVAQANGVQSWKQRPEEERPPLSLLRFASQMVVGVYFGLVALISLSSTANFYIVGLPLAVGLGVLLVAAVGNQTSDFKNTLGAAFLTSPVFYGRPIAILPISLAASITAQKHRRYKVSAVSETLSVRLYRVGLAYLAFTGPLAYSTLYNTAATINYAAETLGSFLSWFNFFPLLGRLVESVLLLPCRIWWLLVGAPGFNSSQFQEWEKLYEFVDSFQDEKRQLAHQVLGIPEGATNEEIHRSYRDLVKVWHPDHNRHQTEEAQRHFLEIQAAYEVLSQPKKPRASWR", "length": 341 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CHS2-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "Dnajc22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKGLLMTYVLWALGGPVGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWKLPSFVAQANRVQSWKQRPEEERPPLSLLRFASQIVVGVYFGLVALVSLSSMDNFYIVGLPLAVGLGVLLVAAVGNQTSDFKNTLGAAFLTSPVFYGRPIAILPISLAASITAQKHRRYKASAGSETLSVRLYRVGLAYLAFTGPLAYSTMYNTAATINYVAETLGSFLSWFSFFPLLGRLVESVLLLPCRIWWLLVGGPGFNSSRFQEWEKLYEFVDSFQDEKLQLAHQVLGVPEGATNEEIHRSYRDLVKVWHPDHNRHQTEEAQRHFLEIQAAYEVLSQPKKPRAS", "length": 339 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N4W6-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "DNAJC22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKGLLVTYALWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWKLPSFVAQANRAQGQRQSPRGVTPPLSPIRFAAQVIVGIYFGLVALISLSSMVNFYIVALPLAVGLGVLLVAAVGNQTSDFKNTLGSAFLTSPIFYGRPIAILPISVAASITAQRHRRYKALVASEPLSVRLYRLGLAYLAFTGPLAYSALCNTAATLSYVAETFGSFLNWFSFFPLLGRLMEFVLLLPYRIWRLLMGETGFNSSCFQEWAKLYEFVHSFQDEKRQLAYQVLGLSEGATNEEIHRSYQELVKVWHPDHNLDQTEEAQRHFLEIQAAYEVLSQPRKPWGSRR", "length": 341 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VX95-1", "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "wus", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGTTQTVSPVAGKDKTNDTSKGSPSKAKSNGHAQGKTKSKEMNALPPQKSVVIAYLCWLFGGIFGLHHLYLHRDRHAFIWWCTLGGYMGIGWMGELFLIPEYVRDANEDPKFVKMFVAKLQAYPKPPYSSKRFVGQVMIGHLFGQVCSMAIPETLVGGWDLSFLHWTIPLFVSLGVWLVGNIGREQGVWWHCLVAAYLAYPARYLIYDETYSLLLTGLVAALTFDGLSKQWRRTPPRRGSPGERTFKLTTAVIIYCAFWGSFLYFNGTISDEDGGEVPIHEAIHNFLASAWWTDLKQALLDTYNYAQHHGWYETWKEVFESMDVDGERNSYKVLGVSATASQAEITAAYRKLSKEYHPDKVKDEGLRAQAHQRFIEIQQAYSVLSKIKSNRRRKNKQYQEEEAIVL", "length": 406 }, "evidence": [ { "id": "Q17QW0", "url": "https://omabrowser.org/oma/group/Q17QW0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q17QW0", "url": "https://www.uniprot.org/uniprotkb/Q17QW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 347, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QW0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q17QW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW0" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 277, "end_pos": 347, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q17QW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW0" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TM2", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 50, "start_aa": "Gly", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QW4-1", "uniprot_ac": "Q17QW4", "uniprot_id": "EID2_BOVIN", "mass": { "chemical_mass": 23882.0, "monoisotopic_mass": 23882.0 }, "refseq": { "ac": "NP_001071517", "name": "EP300-interacting inhibitor of differentiation 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" }, "gene_names": [ { "name": "EID2", "type": "recommended", "evidence": [ { "id": "Q17QW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ] }, { "name": "EID2", "type": "synonym", "evidence": [ { "id": "NP_001071517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" } ] } ], "protein_names": [ { "name": "EP300-interacting inhibitor of differentiation 2", "type": "recommended", "evidence": [ { "id": "Q17QW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW4/entry#names_and_taxonomy" } ] }, { "name": "CREBBP/EP300 inhibitor 2", "type": "synonym", "evidence": [ { "id": "NP_001071517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" }, { "id": "Q17QW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW4/entry#names_and_taxonomy" } ] }, { "name": "EID-1-like inhibitor of differentiation 2", "type": "synonym", "evidence": [ { "id": "NP_001071517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" }, { "id": "Q17QW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW4/entry#names_and_taxonomy" } ] }, { "name": "EID-2", "type": "synonym", "evidence": [ { "id": "NP_001071517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" }, { "id": "Q17QW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW4/entry#names_and_taxonomy" } ] }, { "name": "EP300-interacting inhibitor of differentiation 2", "type": "synonym", "evidence": [ { "id": "NP_001071517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517" } ] } ], "function": [ { "annotation": "Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4#function" }, { "database": "UniProtKB", "id": "Q8N6I1", "url": "https://www.uniprot.org/uniprotkb/Q8N6I1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EID2", "url": "https://www.uniprot.org/uniprotkb/Q17QW4", "locus": {} } ], "crossref": [ { "id": "Q17QW4", "url": "https://alphafold.ebi.ac.uk/entry/Q17QW4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015644", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015644", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615269", "url": "https://www.ncbi.nlm.nih.gov/gene/615269", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615269", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615269", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FDAEYMR", "url": "https://omabrowser.org/oma/group/FDAEYMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QW4", "url": "https://www.orthodb.org/?gene=Q17QW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15556:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15556:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27924", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27924", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071517", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QW4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSELPADQGVPPAGAANDNGDVRQAEVGGRRREPAPAQPVAARDRPMAAAVEGSMASPVEGPVPEAREGPMAASREGLGAAAREARMAEVARLLAEPAEEEGPEGRPRSRPGNGPGLAALPYLRLRHPLGVLGINYQQFLRHYLEHYPIAPGRIQELEGRRRRFVEACRAREAAFDAEYQRNPQRMDFDILTFSITLTASEIINPLIEELGCDKFISRE", "length": 219, "header": "sp|Q17QW4-1|EID2_BOVIN Isoform 1 of EP300-interacting inhibitor of differentiation 2 OS=Bos taurus OX=9913 GN=EID2 PE=2 SV=1 CANONICAL=Q17QW4-1" }, "isoforms": [ { "isoform_ac": "Q17QW4-1", "url": "https://www.uniprot.org/uniprotkb/Q17QW4/entry#Q17QW4-1", "sequence": { "sequence": "MSELPADQGVPPAGAANDNGDVRQAEVGGRRREPAPAQPVAARDRPMAAAVEGSMASPVEGPVPEAREGPMAASREGLGAAAREARMAEVARLLAEPAEEEGPEGRPRSRPGNGPGLAALPYLRLRHPLGVLGINYQQFLRHYLEHYPIAPGRIQELEGRRRRFVEACRAREAAFDAEYQRNPQRMDFDILTFSITLTASEIINPLIEELGCDKFISRE", "length": 219, "header": "sp|Q17QW4-1|EID2_BOVIN Isoform 1 of EP300-interacting inhibitor of differentiation 2 OS=Bos taurus OX=9913 GN=EID2 PE=2 SV=1 CANONICAL=Q17QW4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615269", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615269", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6X7S9-1", "protein_name": "EP300-interacting inhibitor of differentiation 2", "gene_name": "Eid2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQLPAVSSAPQTGAASRDRRLPQAEVGGGRRALPGPARPGETRGRPMAAAREGPAAPAAAARGGRVAAAREGRAAAARGGPGAAPRGGAAAREGPAAAAASREARMAEVARLLGDPLEEEAPEGRPRSRAGGLAAMPYMRFRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDIEYLRNPQRVDFDILTFTIALTASEVINPLIEELGCDKFIHRE", "length": 236 }, "evidence": [ { "id": "Q17QW4", "url": "https://omabrowser.org/oma/group/Q17QW4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N6I1-1", "protein_name": "EP300-interacting inhibitor of differentiation 2", "gene_name": "EID2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAPAAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASEVINPLIEELGCDKFINRE", "length": 236 }, "evidence": [ { "id": "Q17QW4", "url": "https://omabrowser.org/oma/group/Q17QW4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q17QW4", "url": "https://www.uniprot.org/uniprotkb/Q17QW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QW4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QW4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QW4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17QZ8-1", "uniprot_ac": "Q17QZ8", "uniprot_id": "B3GN9_BOVIN", "mass": { "chemical_mass": 43876.0, "monoisotopic_mass": 43876.0 }, "refseq": { "ac": "NP_001069810", "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" }, "gene_names": [ { "name": "B3GNT9", "type": "recommended", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ] }, { "name": "B3GNT9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" } ] } ], "protein_names": [ { "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "type": "recommended", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "BGnT-9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" }, { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "Beta-1,3-Gn-T9", "type": "synonym", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "Beta-1,3-N-acetylglucosaminyltransferase 9", "type": "synonym", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "Beta3Gn-T9", "type": "synonym", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#names_and_taxonomy" } ] }, { "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" } ] }, { "name": "beta-1,3-Gn-T9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" } ] }, { "name": "beta-1,3-N-acetylglucosaminyltransferase 9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" } ] }, { "name": "beta3Gn-T9", "type": "synonym", "evidence": [ { "id": "NP_001069810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B3GNT9", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8", "locus": { "chromosome": "18", "start_pos": 34783770, "end_pos": 34791530, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049665", "url": "https://www.ensembl.org/id/ENSBTAG00000049665" } ] } } ], "crossref": [ { "id": "Q17QZ8", "url": "https://alphafold.ebi.ac.uk/entry/Q17QZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049665", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049665", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614717", "url": "https://www.ncbi.nlm.nih.gov/gene/614717", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614717", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614717", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PFQWKKK", "url": "https://omabrowser.org/oma/group/PFQWKKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q17QZ8", "url": "https://www.orthodb.org/?gene=Q17QZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214:SF91", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214:SF91", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069810", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17QZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRRLRLRREALLTLLLGATLGLLLYAQQEGAAPTTSAPRAQGRAAPGPTPGLRVFQAPDTGAAPPAYEGDTPEPPTPTGPFDFGRYLRAKDQRRFPLLINQPHKCQGNGAFPRGPDLLIAVKSVAADFERRQAVRQTWGAEGRVQGALVRRVFLLGVPRGTGTVAGEAEAGTQTHWSALLRAESRAYADILLWAFDDTFFNLTLKEIHFLAWASDYCPDVRFVFKGDADVFVHVGNLLEFLAPRDPAQDLLAGDVIVQARPIRVRASKYYIPEAVYGLPAYPAYAGGGGFVLSGATLRRLAGACAQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGIPRPSAAPHLHTFDPCFYRELVVVHGLSAADIWLMWHLLHGPNGPACARPWPVPAGPFQWGP", "length": 401, "header": "sp|Q17QZ8-1|B3GN9_BOVIN Isoform 1 of UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 OS=Bos taurus OX=9913 GN=B3GNT9 PE=2 SV=1 CANONICAL=Q17QZ8-1" }, "isoforms": [ { "isoform_ac": "Q17QZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8/entry#Q17QZ8-1", "sequence": { "sequence": "MRRRLRLRREALLTLLLGATLGLLLYAQQEGAAPTTSAPRAQGRAAPGPTPGLRVFQAPDTGAAPPAYEGDTPEPPTPTGPFDFGRYLRAKDQRRFPLLINQPHKCQGNGAFPRGPDLLIAVKSVAADFERRQAVRQTWGAEGRVQGALVRRVFLLGVPRGTGTVAGEAEAGTQTHWSALLRAESRAYADILLWAFDDTFFNLTLKEIHFLAWASDYCPDVRFVFKGDADVFVHVGNLLEFLAPRDPAQDLLAGDVIVQARPIRVRASKYYIPEAVYGLPAYPAYAGGGGFVLSGATLRRLAGACAQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGIPRPSAAPHLHTFDPCFYRELVVVHGLSAADIWLMWHLLHGPNGPACARPWPVPAGPFQWGP", "length": 401, "header": "sp|Q17QZ8-1|B3GN9_BOVIN Isoform 1 of UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 OS=Bos taurus OX=9913 GN=B3GNT9 PE=2 SV=1 CANONICAL=Q17QZ8-1" }, "locus": { "chromosome": "18", "start_pos": 34788587, "end_pos": 34787731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085214.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085214.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058412.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 77, "start_aa": "Thr", "end_pos": 77, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614717", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614717", "resource": "KEGG Pathway" }, { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K1Q3-1", "protein_name": "Hexosyltransferase", "gene_name": "B3gnt9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRRPRLCRDAWLTLLLSAALGLLLYAQRDGVSPTTRAPPARGRQLPRPTPGRRALELPNTAHAAPPAYEGETPVPPTPTDPFDFRRYLRAKDQRRFPLLINQPRKCHSDGASGGSLDLLIAVKSVAADFERREAVRQTWGAEGRVQGALVRRVFLLGVPKGAGSGGAGTRTHWRALLEAESRAYADILLWAFEDTFFNLTLKEIHFLSWASAFCPDVHFVFKGDADVFVHVRNLLQFLEPRDPAQDLLAGDVIVQARPIRARASKYFIPQAVYGLPVYPAYAGGGGFVLSGATLHRLAHACTQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGISQPSAAPHLRTFDPCFYRELVVVHGLSAADIWLMWRLLHGPQGPVCAHPQPVATGPFQWNS", "length": 398 }, "evidence": [ { "id": "Q17QZ8", "url": "https://omabrowser.org/oma/group/Q17QZ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZNW2-1", "protein_name": "Hexosyltransferase", "gene_name": "B3GNT9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRRLRLRGEASITLLLGAALGLLLYAQRDGAAQTTSAPRAEGVAAPGPTPGVRVFEAPDTGAAPPVYEGDTPEPPTPTPTGPFDFGRYLRAKDQRRFPLLINQPHKCRGNGVPADGPDLLIAVKSVAADFERRQAVRQTWGAEGRVQGALVRRVFLLGVPRAAGADGADAADAEGAGTRTHWSAMLRAESRAYADILLWAFDDTFFNLTLKEIHFLAWASAYCPDVRFVFKGDSDVFVHVGNLLEFLAPRDPAQDLLAGDVIVQARPIRRRTSKYYIPEAVYGLQAYPAYAGGGGFVLSGATLHRLAGACAQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGIPRPSAAPHLRTFDPCFYRELVVVHGLSAADIWLMWHLLHGPHGPACARPWPVAAGPFQWGP", "length": 407 }, "evidence": [ { "id": "Q17QZ8", "url": "https://omabrowser.org/oma/group/Q17QZ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6UX72-1", "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "gene_name": "B3GNT9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRRLRLRRDALLTLLLGASLGLLLYAQRDGAAPTASAPRGRGRAAPRPTPGPRAFQLPDAGAAPPAYEGDTPAPPTPTGPFDFARYLRAKDQRRFPLLINQPHKCRGDGAPGGRPDLLIAVKSVAEDFERRQAVRQTWGAEGRVQGALVRRVFLLGVPRGAGSGGADEVGEGARTHWRALLRAESLAYADILLWAFDDTFFNLTLKEIHFLAWASAFCPDVRFVFKGDADVFVNVGNLLEFLAPRDPAQDLLAGDVIVHARPIRTRASKYYIPEAVYGLPAYPAYAGGGGFVLSGATLHRLAGACAQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGIPQPSAAPHLSTFDPCFYRELVVVHGLSAADIWLMWRLLHGPHGPACAHPQPVAAGPFQWDS", "length": 402 }, "evidence": [ { "id": "Q17QZ8", "url": "https://omabrowser.org/oma/group/Q17QZ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VI16-1", "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "gene_name": "B3gnt9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRRRRRPRLCPDAWLTLLLSAALGLLLYAQRDVASPTTRPPARGPQLPRPTPSLRARELPNTARAAPLAYEGDTPVPPTPTDPFDFGGYLRAKDQRRFPLLINQRRKCRSDGASGGSPDLLIAVKSVAADFERREAVRQTWGAEGRVQGALVRRVFLLGVPKGAGSGGAGTRSHWRTLLEAESRAYADILLWAFEDTFFNLTLKEIHFLSWASAFCPDVHFVFKGDADVFVHVRNLLQFLELRDPAQDLLAGDVIVQARPIRARASKYFIPRAVYGLPVYPAYAGGGGFVLSGATLRRLADACSQVELFPIDDVFLGMCLQRLRLTPEPHPAFRTFGISQPSAAPHLRTFDPCFYRELVVVHGLSAADIWLMWRLLHGPQGPVCAHPQPVATGPFQWNS", "length": 399 }, "evidence": [ { "id": "Q17QZ8", "url": "https://omabrowser.org/oma/group/Q17QZ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "pmid": "" }, { "name": "hexosyltransferase activity", "id": "GO:0016758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016758", "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "pmid": "" }, { "name": "poly-N-acetyllactosamine biosynthetic process", "id": "GO:0030311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030311", "evidence": [ { "database": "UniProtKB", "id": "Q17QZ8", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-914010", "name": "B3GNT6 transfers GlcNAc to Tn antigen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q17QZ8-1", "A0AAA9TA32-1", "F1MG37-1", "F1MGN7-1", "F1MSS4-1" ], "evidence": [ { "id": "R-BTA-914010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-914010" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TA32", "gene_name": "B3GNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TA32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA32" } ] } ] }, { "uniprot_ac": "F1MG37", "gene_name": "B3GNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ] } ] }, { "uniprot_ac": "F1MGN7", "gene_name": "B3GNT6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ] } ] }, { "uniprot_ac": "F1MSS4", "gene_name": "B3GNT4", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSS4" } ] } ] }, { "uniprot_ac": "Q17QZ8", "gene_name": "B3GNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17QZ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 401, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17QZ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17QZ8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35, 50, 77 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q17R01-1", "uniprot_ac": "Q17R01", "uniprot_id": "FXL14_BOVIN", "mass": { "chemical_mass": 43864.0, "monoisotopic_mass": 43864.0 }, "refseq": { "ac": "NP_001069415", "name": "F-box/LRR-repeat protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069415" }, "gene_names": [ { "name": "FBXL14", "type": "recommended", "evidence": [ { "id": "Q17R01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ] }, { "name": "FBXL14", "type": "synonym", "evidence": [ { "id": "NP_001069415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069415" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 14", "type": "recommended", "evidence": [ { "id": "Q17R01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R01/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 14", "type": "synonym", "evidence": [ { "id": "Q17R01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R01/entry#names_and_taxonomy" } ] }, { "name": "F-box/LRR-repeat protein 14", "type": "synonym", "evidence": [ { "id": "NP_001069415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069415" } ] } ], "function": [ { "annotation": "Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL14", "url": "https://www.uniprot.org/uniprotkb/Q17R01", "locus": { "chromosome": "5", "start_pos": 108102543, "end_pos": 108113821, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052374", "url": "https://www.ensembl.org/id/ENSBTAG00000052374" } ] } } ], "crossref": [ { "id": "Q17R01", "url": "https://alphafold.ebi.ac.uk/entry/Q17R01", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22125", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22125", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531211", "url": "https://www.ncbi.nlm.nih.gov/gene/531211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531211", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531211", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q17R01", "url": "https://www.orthodb.org/?gene=Q17R01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF190", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF190", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069415", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q17R01-1", "url": "https://www.uniprot.org/uniprotkb/Q17R01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKVR", "length": 400, "header": "sp|Q17R01-1|FXL14_BOVIN Isoform 1 of F-box/LRR-repeat protein 14 OS=Bos taurus OX=9913 GN=FBXL14 PE=2 SV=1 CANONICAL=Q17R01-1" }, "isoforms": [ { "isoform_ac": "Q17R01-1", "url": "https://www.uniprot.org/uniprotkb/Q17R01/entry#Q17R01-1", "sequence": { "sequence": "METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKVR", "length": 400, "header": "sp|Q17R01-1|FXL14_BOVIN Isoform 1 of F-box/LRR-repeat protein 14 OS=Bos taurus OX=9913 GN=FBXL14 PE=2 SV=1 CANONICAL=Q17R01-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531211", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531211", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q17R01", "url": "https://www.uniprot.org/uniprotkb/Q17R01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q17R01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q17R01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q17R01" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 123, "end_pos": 125 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 234, "end_pos": 236 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1ECS6-1", "uniprot_ac": "Q1ECS6", "uniprot_id": "CIST1_BOVIN", "mass": { "chemical_mass": 24209.0, "monoisotopic_mass": 24209.0 }, "refseq": { "ac": "NP_001068739", "name": "protein CIST1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739" }, "gene_names": [ { "name": "CIST1", "type": "recommended", "evidence": [ { "id": "Q1ECS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6" } ] }, { "name": "CIST1", "type": "synonym", "evidence": [ { "id": "NP_001068739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739" } ] } ], "protein_names": [ { "name": "Protein CIST1", "type": "recommended", "evidence": [ { "id": "Q1ECS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6/entry#names_and_taxonomy" } ] }, { "name": "Intestine-specific transcript 1 protein", "type": "synonym", "evidence": [ { "id": "Q1ECS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6/entry#names_and_taxonomy" } ] }, { "name": "Protein CIST1", "type": "synonym", "evidence": [ { "id": "NP_001068739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739" } ] }, { "name": "intestine-specific transcript 1 protein", "type": "synonym", "evidence": [ { "id": "NP_001068739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739" } ] }, { "name": "protein CIST1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001068739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1ECS6", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIST1", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6", "locus": { "chromosome": "7", "start_pos": 4984470, "end_pos": 4979525, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033886", "url": "https://www.ensembl.org/id/ENSBTAG00000033886" } ] } } ], "crossref": [ { "id": "Q1ECS6", "url": "https://alphafold.ebi.ac.uk/entry/Q1ECS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "506589", "url": "https://www.ncbi.nlm.nih.gov/gene/506589", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:506589", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506589", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1ECS6", "url": "https://www.orthodb.org/?gene=Q1ECS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "NP_001068739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068739", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1ECS6", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1ECS6-1", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSQPPLPPPPPPLLLLALLLLLKVSDTSSSVSTATSTASETDNLTSKPLTSSFSSSSPTVWEKQTSQEKPETASTSHPDSSSSESTISHSPSNSGTTSTTQPTSSQPEPDTHPSSGSPSSEHTVTSPSLGSVSLATLPWSPTHPKPSTGPPSVSLATTDRTFETSGYAPGDSGVPRLHRNPGVVVAVCLLVSALLIGGAIMAVRRCHNGVSEFQKLDEGLVSRRSSSAHHTLP", "length": 235, "header": "sp|Q1ECS6-1|CIST1_BOVIN Isoform 1 of Protein CIST1 OS=Bos taurus OX=9913 GN=CIST1 PE=2 SV=1 CANONICAL=Q1ECS6-1" }, "isoforms": [ { "isoform_ac": "Q1ECS6-1", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6/entry#Q1ECS6-1", "sequence": { "sequence": "MASSQPPLPPPPPPLLLLALLLLLKVSDTSSSVSTATSTASETDNLTSKPLTSSFSSSSPTVWEKQTSQEKPETASTSHPDSSSSESTISHSPSNSGTTSTTQPTSSQPEPDTHPSSGSPSSEHTVTSPSLGSVSLATLPWSPTHPKPSTGPPSVSLATTDRTFETSGYAPGDSGVPRLHRNPGVVVAVCLLVSALLIGGAIMAVRRCHNGVSEFQKLDEGLVSRRSSSAHHTLP", "length": 235, "header": "sp|Q1ECS6-1|CIST1_BOVIN Isoform 1 of Protein CIST1 OS=Bos taurus OX=9913 GN=CIST1 PE=2 SV=1 CANONICAL=Q1ECS6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 45, "start_aa": "Asn", "end_pos": 45, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn45", "evidence": [ { "id": "Q1ECS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Discovery of eight novel divergent homologs expressed in cattle placenta.", "journal": "Physiol. Genomics", "date": "2006", "authors": "Larson Joshua H, Kumar Charu G, Everts Robin E, Green Cheryl A, Everts-van der Wind Annelie, Band Mark R, Lewin Harris A", "evidence": [ { "database": "UniProtKB", "id": "Q1ECS6", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6" } ], "reference": [ { "type": "PubMed", "id": "16554549", "url": "https://glygen.org/publication/PubMed/16554549" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q1ECS6", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:506589", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506589", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q1ECS6", "url": "https://www.uniprot.org/uniprotkb/Q1ECS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1ECS6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1ECS6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1ECS6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 45 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JP73-1", "uniprot_ac": "Q1JP73", "uniprot_id": "QNG1_BOVIN", "mass": { "chemical_mass": 39037.0, "monoisotopic_mass": 39037.0 }, "refseq": { "ac": "NP_001070446", "name": "queuosine 5'-phosphate N-glycosylase/hydrolase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" }, "gene_names": [ { "name": "QNG1", "type": "recommended", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ] }, { "name": "C8H9orf64", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "C9orf64", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "QNG1", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] } ], "protein_names": [ { "name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "type": "recommended", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73/entry#names_and_taxonomy" } ] }, { "name": "3.2.2.-", "type": "synonym", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73/entry#names_and_taxonomy" } ] }, { "name": "Queuosine-nucleotide N-glycosylase/hydrolase", "type": "synonym", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73/entry#names_and_taxonomy" } ] }, { "name": "UPF0553 protein C9orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "chromosome 8 C9orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "queuosine 5'-phosphate N-glycosylase/hydrolase", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "queuosine salvage protein", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "queuosine-nucleotide N-glycosylase/hydrolase", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] }, { "name": "uncharacterized protein C9ORF64", "type": "synonym", "evidence": [ { "id": "NP_001070446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.", "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73#function" }, { "database": "UniProtKB", "id": "Q5T6V5", "url": "https://www.uniprot.org/uniprotkb/Q5T6V5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "QNG1", "url": "https://www.uniprot.org/uniprotkb/Q1JP73", "locus": { "chromosome": "8", "start_pos": 77189041, "end_pos": 77200796, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006478", "url": "https://www.ensembl.org/id/ENSBTAG00000006478" } ] } } ], "crossref": [ { "id": "Q1JP73", "url": "https://alphafold.ebi.ac.uk/entry/Q1JP73", "database": "AlphaFoldDB", "categories": [] }, { "id": "767897", "url": "https://www.ncbi.nlm.nih.gov/gene/767897", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767897", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767897", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1JP73", "url": "https://www.orthodb.org/?gene=Q1JP73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21314", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21314", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21314:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21314:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10343", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10343", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070446", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "75387", "url": "https://www.rhea-db.org/rhea/75387", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JP73-1", "url": "https://www.uniprot.org/uniprotkb/Q1JP73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGLLTPRESAKFIAENSRDVFIDDGGVRRVAELLLAKATGPELRIEGWKAIHELNPRGTDEAAVNWVFVTDTLNFSFWSESDEYKCQVGFGGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDEVRHILRSDTDVPMPLIEERHRILNETGKILLEKFGGSFLNCVQKSDKSAQKLLHLVVENFPSYRDVTQFEGKRISFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLVYLGALKYSNELLEKLLKGEMLFYGNRQEVEIRGCSVWCVELIRDCLLELIEKKGEKTTGEINSILLDYYLWDYARDHREDMKGIPFHHTRCIYY", "length": 341, "header": "sp|Q1JP73-1|QNG1_BOVIN Isoform 1 of Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Bos taurus OX=9913 GN=QNG1 PE=2 SV=1 CANONICAL=Q1JP73-1" }, "isoforms": [ { "isoform_ac": "Q1JP73-1", "url": "https://www.uniprot.org/uniprotkb/Q1JP73/entry#Q1JP73-1", "sequence": { "sequence": "MDGLLTPRESAKFIAENSRDVFIDDGGVRRVAELLLAKATGPELRIEGWKAIHELNPRGTDEAAVNWVFVTDTLNFSFWSESDEYKCQVGFGGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDEVRHILRSDTDVPMPLIEERHRILNETGKILLEKFGGSFLNCVQKSDKSAQKLLHLVVENFPSYRDVTQFEGKRISFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLVYLGALKYSNELLEKLLKGEMLFYGNRQEVEIRGCSVWCVELIRDCLLELIEKKGEKTTGEINSILLDYYLWDYARDHREDMKGIPFHHTRCIYY", "length": 341, "header": "sp|Q1JP73-1|QNG1_BOVIN Isoform 1 of Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Bos taurus OX=9913 GN=QNG1 PE=2 SV=1 CANONICAL=Q1JP73-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:767897", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767897", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ], "pmid": "" }, { "name": "nucleoside salvage", "id": "GO:0043174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043174", "evidence": [ { "database": "UniProtKB", "id": "Q1JP73", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "75387", "name": "", "equation": "queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JP73-1", "F1MEP1-1" ], "evidence": [ { "id": "75387", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75387" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MEP1", "gene_name": "QNG1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ] } ] }, { "uniprot_ac": "Q1JP73", "gene_name": "QNG1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JP73-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JP73-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JP73" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JP79-1", "uniprot_ac": "Q1JP79", "uniprot_id": "ARC1A_BOVIN", "mass": { "chemical_mass": 41539.0, "monoisotopic_mass": 41539.0 }, "refseq": { "ac": "NP_001068827", "name": "actin-related protein 2/3 complex subunit 1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068827" }, "gene_names": [ { "name": "ARPC1A", "type": "recommended", "evidence": [ { "id": "Q1JP79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ] }, { "name": "ARPC1A", "type": "synonym", "evidence": [ { "id": "NP_001068827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068827" } ] } ], "protein_names": [ { "name": "Actin-related protein 2/3 complex subunit 1A", "type": "recommended", "evidence": [ { "id": "Q1JP79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP79/entry#names_and_taxonomy" } ] }, { "name": "actin related protein 2/3 complex, subunit 1A, 41kDa", "type": "synonym", "evidence": [ { "id": "NP_001068827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068827" } ] }, { "name": "actin-related protein 2/3 complex subunit 1A", "type": "synonym", "evidence": [ { "id": "NP_001068827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068827" } ] } ], "function": [ { "annotation": "Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79#function" }, { "database": "UniProtKB", "id": "Q92747", "url": "https://www.uniprot.org/uniprotkb/Q92747#function" }, { "database": "UniProtKB", "id": "Q8AVT9", "url": "https://www.uniprot.org/uniprotkb/Q8AVT9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARPC1A", "url": "https://www.uniprot.org/uniprotkb/Q1JP79", "locus": { "chromosome": "25", "start_pos": 37022860, "end_pos": 37046302, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004242", "url": "https://www.ensembl.org/id/ENSBTAG00000004242" } ] } } ], "crossref": [ { "id": "Q1JP79", "url": "https://alphafold.ebi.ac.uk/entry/Q1JP79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508402", "url": "https://www.ncbi.nlm.nih.gov/gene/508402", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7T5Q", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=7T5Q&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8TAH", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8TAH&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9DLX", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9DLX&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9DLZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9DLZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9EAM", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9EAM&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508402", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508402", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVWEPSP", "url": "https://omabrowser.org/oma/group/YVWEPSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1JP79", "url": "https://www.orthodb.org/?gene=Q1JP79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10709", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10709", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10709:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10709:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00007t5q", "url": "https://www.rcsb.org/structure/pdb_00007t5q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008tah", "url": "https://www.rcsb.org/structure/pdb_00008tah", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009dlx", "url": "https://www.rcsb.org/structure/pdb_00009dlx", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009dlz", "url": "https://www.rcsb.org/structure/pdb_00009dlz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009eam", "url": "https://www.rcsb.org/structure/pdb_00009eam", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7T5Q", "url": "https://www.rcsb.org/structure/7T5Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8TAH", "url": "https://www.rcsb.org/structure/8TAH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9DLX", "url": "https://www.rcsb.org/structure/9DLX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9DLZ", "url": "https://www.rcsb.org/structure/9DLZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9EAM", "url": "https://www.rcsb.org/structure/9EAM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068827", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JP79-1", "url": "https://www.uniprot.org/uniprotkb/Q1JP79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGGQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM", "length": 370, "header": "sp|Q1JP79-1|ARC1A_BOVIN Isoform 1 of Actin-related protein 2/3 complex subunit 1A OS=Bos taurus OX=9913 GN=ARPC1A PE=1 SV=1 CANONICAL=Q1JP79-1" }, "isoforms": [ { "isoform_ac": "Q1JP79-1", "url": "https://www.uniprot.org/uniprotkb/Q1JP79/entry#Q1JP79-1", "sequence": { "sequence": "MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGGQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM", "length": 370, "header": "sp|Q1JP79-1|ARC1A_BOVIN Isoform 1 of Actin-related protein 2/3 complex subunit 1A OS=Bos taurus OX=9913 GN=ARPC1A PE=1 SV=1 CANONICAL=Q1JP79-1" }, "locus": { "chromosome": "25", "start_pos": 37040606, "end_pos": 37023218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005555.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005555.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005555.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005555.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508402", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508402", "resource": "KEGG Pathway" }, { "id": "R-BTA-2029482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "resource": "Reactome", "description": "Regulation of actin dynamics for phagocytic cup formation" }, { "id": "R-BTA-3928662", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-BTA-5663213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663213", "resource": "Reactome", "description": "RHO GTPases Activate WASPs and WAVEs" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I391-1", "protein_name": "Actin-related protein 2/3 complex subunit", "gene_name": "Arpc1a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGNRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM", "length": 370 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O80856-1", "protein_name": "Actin-related protein 2/3 complex subunit 1A", "gene_name": "ARPC1A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVVDVHRFAESITCHAWSPDLSMVALCPNNTEVHIYKSLSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVILRLNRAALCVQWSPKENKFAVGSGAKTVCICYYEQENNWWVSKLIRKRHESSVTSVAWHPNNVLLATTSTDGKCRVFSTFIKGVDTKDSKAGSPAETKFGEQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLAQSVAFRDLPLRDVLFISEKMVIGVGYDSNPMVFASDDTGIWSFIRYIGEKKAASSNSSYSSQFSEAFGKFYGSQSKSTTANDASESRGGVHDNCINSIVSLSKAGSPKVMRFSTSGLDGKVAIWDLENMEQELGNQF", "length": 378 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O96622-1", "protein_name": "Actin-related protein 2/3 complex subunit 1", "gene_name": "arcA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSAFEIEHLASCITAHAWNADRSRVALCPNNNEVHIYAKQGTSWVVEHVLAEHDQLVTSIDWAPKTNRILTSSQDRNAYVWTFKDGQWKPVLVLLRINRAATHVKWSPQENKFAVATGAKLVCICFFEEEHDWWASNHIKKHKSTVLKVDWHPNNLLLATSSSDYKVRVFDAYIKKADGRSVTRPYGEVAFGEPVFEFDQCASWVHALKWSPSGSTLAYSSHDGVFAVANFSTNPPTIEKLRVRNLPLRDLLYITENSIAGVGYDCAPLLITNQNGWKYSGEMDKASEGGAAAGSETSARKLFQNKVDLGESKSADKKLTTVHQNCITSIVPFKSVGGVVSDFSTSGLDGNIVVWHVKALEAKNKFKVI", "length": 369 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O97182-1", "protein_name": "Actin-related protein 2/3 complex subunit", "gene_name": "Arpc1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAETYTFGTSLASITCHAWNKDRTQIALSPNNHEIHIYSREGSDWKLADVLNQHDLRVMGIDWAKNTNRIVSCAADRNAYVWTQGDDGKWKPALVLLRINRAATCVKWSPAENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVTSLDWHPNNVLLLAGSTDYKVRVFSAFIKDIEEPPTPTPWGNRKPLGQLMAEFRNSQTSGGGWINSVSFSSDGNKVCWVGHDSCVSIADATNGNTVIRCRTGYLPFLSCEWVSPTSVVVAGYSCVPLLYSLTADGKLVLSGKLDKSQKKESSGITAMRIFQSMDRNMRTENTDTVVDSIHQNAITSVRLYAGDKASATKVSTSGVDGQLVIWNVEQGGINGGMRNLQI", "length": 377 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P38328-1", "protein_name": "Actin-related protein 2/3 complex subunit 1", "gene_name": "ARC40", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSFSNSKDKSVVAVYKLVKAPIYSHCFSQDKSILAVTCETDCLVYRVSNNTPPVLFATLKDHDKTITAVDISIHGRIVTCSQDRNAYVWEPLSDGTYKPTLVLLRINRAATSVTWAPNGYKFAVGSSARIIAVCYYEHENNWWVSKHIKKPIKSTINCLSWHANGVLLAAGGTDGFMRVFSGFIKGLDSKESVAGSPWGQKFPFGCLIREWYQGSYIHDVEWRSQMERIAYVAHDGTLNVVDYQSPVQSVNAPEGLPYRSLVWINDHEIVCGGYSCHPVLFSEASEGWKFAKNLDKSDNNKSSALTASGNTDELSGNNDESSTFGISALRKFKELDLKGKVSTDVQESAHENAIVELRPFAESNGQITQVSSCGLDGKIVIYTI", "length": 384 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q92747-1", "protein_name": "Actin-related protein 2/3 complex subunit 1A", "gene_name": "ARPC1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM", "length": 370 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0Q6-1", "protein_name": "Actin-related protein 2/3 complex subunit 1A", "gene_name": "Arpc1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGNRLAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM", "length": 370 }, "evidence": [ { "id": "Q1JP79", "url": "https://omabrowser.org/oma/group/Q1JP79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" }, { "name": "Arp2/3 protein complex", "id": "GO:0005885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005885", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" }, { "name": "muscle cell projection membrane", "id": "GO:0036195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036195", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Arp2/3 complex-mediated actin nucleation", "id": "GO:0034314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034314", "evidence": [ { "database": "UniProtKB", "id": "Q1JP79", "url": "https://www.uniprot.org/uniprotkb/Q1JP79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JP79-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JP79-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JP79" }, { "pdb_id": "8tah", "pdb_chain": "c", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/8tah.pdb", "url_external": "https://www.rcsb.org/structure/8tah" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 296, "end_pos": 298 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JPA6-1", "uniprot_ac": "Q1JPA6", "uniprot_id": "ARY1_BOVIN", "mass": { "chemical_mass": 34199.0, "monoisotopic_mass": 34199.0 }, "refseq": { "ac": "NP_001069040", "name": "arylamine N-acetyltransferase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" }, "gene_names": [ { "name": "NAT1", "type": "recommended", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ] }, { "name": "NAT1", "type": "synonym", "evidence": [ { "id": "NP_001069040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" } ] } ], "protein_names": [ { "name": "Arylamine N-acetyltransferase 1", "type": "recommended", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.5", "type": "synonym", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#names_and_taxonomy" } ] }, { "name": "Arylamide acetylase 1", "type": "synonym", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#names_and_taxonomy" } ] }, { "name": "N-acetyltransferase type 1", "type": "synonym", "evidence": [ { "id": "NP_001069040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" }, { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#names_and_taxonomy" } ] }, { "name": "NAT-1", "type": "synonym", "evidence": [ { "id": "NP_001069040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" }, { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#names_and_taxonomy" } ] }, { "name": "arylamide acetylase 1", "type": "synonym", "evidence": [ { "id": "NP_001069040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" } ] }, { "name": "arylamine N-acetyltransferase 1", "type": "synonym", "evidence": [ { "id": "NP_001069040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040" } ] } ], "function": [ { "annotation": "Participates in the detoxification of a plethora of hydrazine and arylamine drugs.", "evidence": [ { "database": "UniProtKB", "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAT1", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6", "locus": { "chromosome": "27", "start_pos": 39013596, "end_pos": 39024154, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016473", "url": "https://www.ensembl.org/id/ENSBTAG00000016473" } ] } } ], "crossref": [ { "id": "Q1JPA6", "url": "https://alphafold.ebi.ac.uk/entry/Q1JPA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016473", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016473", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512603", "url": "https://www.ncbi.nlm.nih.gov/gene/512603", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512603", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYEHNTL", "url": "https://omabrowser.org/oma/group/CYEHNTL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1JPA6", "url": "https://www.orthodb.org/?gene=Q1JPA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11786", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11786", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11786:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11786:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156582", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156582", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9753281", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069040", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16613", "url": "https://www.rhea-db.org/rhea/16613", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPA6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDIDAYFERIGYKNSRDKLDLETLTDILQHQIRAIPFENLNIHCGEAMELDLEVIFDQIVRRKRGGWCLQVNHLLYWALTMIGFETTILGGYVYNTFNDKYSSAMIHLLLKVTIDGRDYIADAGFGRSYQMWQPLELISGKYQPQTPCIFRLTEDRGTWYLDQIRREQYIPNQDFLDSDLLEKNEYRKIYSFTLEPRTIKDFESVNTYLQESPASVFTSKSFCSLQTPEGVHCLVGFTLTYRRFNYKDNTDLVEFKTLNEKEIEENLKNIFNISLEKKLTPKHGDKFFTI", "length": 290, "header": "sp|Q1JPA6-1|ARY1_BOVIN Isoform 1 of Arylamine N-acetyltransferase 1 OS=Bos taurus OX=9913 GN=NAT1 PE=2 SV=1 CANONICAL=Q1JPA6-1" }, "isoforms": [ { "isoform_ac": "Q1JPA6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6/entry#Q1JPA6-1", "sequence": { "sequence": "MDIDAYFERIGYKNSRDKLDLETLTDILQHQIRAIPFENLNIHCGEAMELDLEVIFDQIVRRKRGGWCLQVNHLLYWALTMIGFETTILGGYVYNTFNDKYSSAMIHLLLKVTIDGRDYIADAGFGRSYQMWQPLELISGKYQPQTPCIFRLTEDRGTWYLDQIRREQYIPNQDFLDSDLLEKNEYRKIYSFTLEPRTIKDFESVNTYLQESPASVFTSKSFCSLQTPEGVHCLVGFTLTYRRFNYKDNTDLVEFKTLNEKEIEENLKNIFNISLEKKLTPKHGDKFFTI", "length": 290, "header": "sp|Q1JPA6-1|ARY1_BOVIN Isoform 1 of Arylamine N-acetyltransferase 1 OS=Bos taurus OX=9913 GN=NAT1 PE=2 SV=1 CANONICAL=Q1JPA6-1" }, "locus": { "chromosome": "27", "start_pos": 39016317, "end_pos": 39015448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123996.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123996.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080244.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080244.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512603", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512603", "resource": "KEGG Pathway" }, { "id": "R-BTA-156582", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156582", "resource": "Reactome", "description": "Acetylation" }, { "id": "R-BTA-9753281", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "resource": "Reactome", "description": "Paracetamol ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AB32TTY3-1", "protein_name": "arylamine N-acetyltransferase", "gene_name": "si:dkey-78a14.4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MIRHDHLALDTTWRGKKRFIMDLREYLKRIGFTGQLNKPDLDSLFTIHKLHVMSVPFENLSVHNGEKNSMDLRVIYNKIVESNRGGWCCENNLLFSWALKEMGYKSTILSGRVFNSLEQDFLPNDSHLINLVEIDGKQYIADVSFGVSCQIWYPLELISGKDQPQPPGVFRLTNNGEKWILEKTGRKQIIVDNGFADSGLVDKRLIKTIYCFTLTPRVVEYFLKMSVMLQTNPSSLFMLKTICSLQTATGFRALIGWTYSEVTFKEDSDSVEMKKIPDDEIEAVLKEKFNMVLINKFTPKNNKAFYSI", "length": 308 }, "evidence": [ { "id": "Q1JPA6", "url": "https://omabrowser.org/oma/group/Q1JPA6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P5U3-1", "protein_name": "arylamine N-acetyltransferase", "gene_name": "PNAT10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNLEEYFARTGYKGSLENQDLETLTDIFQHHIRAVPFENLSIHCGEKITLELEHVYNKIVHKKRGGWCMENNQLLGWVLKCLGYDTSFLGAYVFNPHENAYATIMTHLLVKVVIEGKAYIVDAGFGVSYQMWQPMELVSGKDQPQAPGIFRFTEKNAIWYLEKMRRKQYIPNQNFSNSDLLEKKDCRKVYMFSLEPRTVEDFCFQCTYLQTSPDSLFTKKSICTLQTTDGFRALIGWTLTETKYNYKENMDLVEFITLKDEEVEKTLKDKFNITLERKLVPINIKGFYTI", "length": 290 }, "evidence": [ { "id": "Q1JPA6", "url": "https://omabrowser.org/oma/group/Q1JPA6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P18440-1", "protein_name": "Arylamine N-acetyltransferase 1", "gene_name": "NAT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI", "length": 290 }, "evidence": [ { "id": "Q1JPA6", "url": "https://omabrowser.org/oma/group/Q1JPA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P50295-1", "protein_name": "Arylamine N-acetyltransferase 2", "gene_name": "Nat2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDIEAYFERIGYQSTRSKLDLKTLTEILQHQIRAIPFENLNIHCGESMELSLEAIFDQIVRKKRGGWCLQVNHLLYWALTKLGFETTMLGGYVFNTPANKYSSGMIHLLVQVTISGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWYLDQIRREQYVPNQEFINSDLLEKNKYRKIYSFTLEPRTIEDFESMNTYLQTSPASVFTSKSFCSLQTPEGVHCLVGSTLTYRRFSYKDNVDLVEFKSLTEEEIEDVLRTIFGVSLERKLVPKHGDRFFTI", "length": 290 }, "evidence": [ { "id": "Q1JPA6", "url": "https://omabrowser.org/oma/group/Q1JPA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q921C9-1", "protein_name": "arylamine N-acetyltransferase", "gene_name": "Nat2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDIDAYFERIGYQNSRNKLDLQTLTEILQHQIQTIPFENLNIHCGESMELGLETIFDQIVKKKRGGWCLQVNHLLYWALTKMGFETTMLGGYVFNTPANKYSSGMIHLLVQVTISDRNYIVDAGFGRSLQMWEPLELASGKDQPQVPAIFRLTEENETWYLDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINAYLQTSPASVFTSKSFCSLQTPEGVHCLVGCTLTYRKFSYKDNVDLVEFKSLKEEEIEDVLKTIFGISLEKKLVPKHGDRFFTI", "length": 290 }, "evidence": [ { "id": "Q1JPA6", "url": "https://omabrowser.org/oma/group/Q1JPA6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "arylamine N-acetyltransferase activity", "id": "GO:0004060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004060", "evidence": [ { "database": "UniProtKB", "id": "Q1JPA6", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16613", "name": "", "equation": "an arylamine + acetyl-CoA = an N-acetylarylamine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "16613", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16613" } ] }, { "id": "R-BTA-158832", "name": "The acetyl group from acetyl-CoA is transferred to NAT2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-158692" ], "output_participant_list": [ "R-BTA-158833" ], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "R-BTA-158832", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-158832" } ] }, { "id": "R-BTA-174959", "name": "The acetyl group from acetyl-CoA is transferred to NAT1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "R-BTA-174959", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174959" } ] }, { "id": "R-BTA-174963", "name": "NAT1 acetylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "R-BTA-174963", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174963" } ] }, { "id": "R-BTA-174967", "name": "NAT2 acetylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "R-BTA-174967", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174967" } ] }, { "id": "R-BTA-9753676", "name": "NAT1,2 acetylate APAP-Cys to APAP-Mer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9753653" ], "output_participant_list": [ "R-ALL-9753642" ], "enzyme_list": [ "Q1JPA6-1" ], "evidence": [ { "id": "R-BTA-9753676", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753676" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9753642", "participant_name": "APAP-Mer [cytosol]", "crossref": [ { "id": "ZINC000002528460", "database": "ZINC", "url": "" }, { "id": "133438", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9753653", "participant_name": "APAP-Cys [cytosol]", "crossref": [ { "id": "133067", "database": "ChEBI", "url": "" }, { "id": "ZINC000002570863", "database": "ZINC", "url": "" }, { "id": "ZINC000021981126", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-BTA-158692", "participant_name": "NAT2 [cytosol]", "crossref": [ { "id": "Q1JPA6", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000016473", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000091763", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000080244", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000098202", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000045530", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000078617", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000123996", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000048506", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000132251", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000111369", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000103477", "database": "ENSEMBL", "url": "" }, { "id": "2.3.1.5", "database": "IntEnz", "url": "" }, { "id": "XP_005226218.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226221.1", "database": "RefSeq", "url": "" }, { "id": "XP_010818673.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226220.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226217.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226219.1", "database": "RefSeq", "url": "" }, { "id": "NP_001069040.1", "database": "RefSeq", "url": "" }, { "id": "XP_059738187.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-158833", "participant_name": "AcC-NAT2 [cytosol]", "crossref": [ { "id": "ENSBTAT00000048506", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226220.1", "database": "RefSeq", "url": "" }, { "id": "XP_059738187.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000098202", "database": "ENSEMBL", "url": "" }, { "id": "2.3.1.5", "database": "IntEnz", "url": "" }, { "id": "ENSBTAP00000091763", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226221.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000078617", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226219.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAT00000111369", "database": "ENSEMBL", "url": "" }, { "id": "Q1JPA6", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000103477", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000080244", "database": "ENSEMBL", "url": "" }, { "id": "XP_010818673.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAT00000123996", "database": "ENSEMBL", "url": "" }, { "id": "NP_001069040.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000045530", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226218.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000016473", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000132251", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226217.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q1JPA6", "gene_name": "NAT1", "activity": [ { "ec_number": "2.3.1.5", "activity": "an arylamine + acetyl-CoA = an N-acetylarylamine + CoA.", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ] }, { "ec_number": "2.3.1.5", "activity": "", "evidence": [ { "id": "Q1JPA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPA6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JPA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JPA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JPA6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.5", "ec_name": "an arylamine + acetyl-CoA = an N-acetylarylamine + CoA.", "evidence": [ { "id": "2.3.1.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.5" }, { "id": "2.3.1.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.5" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JPG1-1", "uniprot_ac": "Q1JPG1", "uniprot_id": "RS10B_BOVIN", "mass": { "chemical_mass": 95887.0, "monoisotopic_mass": 95887.0 }, "refseq": {}, "gene_names": [ { "name": "RSPH10B", "type": "recommended", "evidence": [ { "id": "Q1JPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ] } ], "protein_names": [ { "name": "Radial spoke head 10 homolog B", "type": "recommended", "evidence": [ { "id": "Q1JPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility.", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1#function" }, { "database": "UniProtKB", "id": "E9PYQ0", "url": "https://www.uniprot.org/uniprotkb/E9PYQ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSPH10B", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1", "locus": { "chromosome": "25", "start_pos": 37980915, "end_pos": 38005641, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005908", "url": "https://www.ensembl.org/id/ENSBTAG00000005908" } ] } } ], "crossref": [ { "id": "Q1JPG1", "url": "https://alphafold.ebi.ac.uk/entry/Q1JPG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q1JPG1", "url": "https://www.orthodb.org/?gene=Q1JPG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46613", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46613", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46613:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46613:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPG1-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKEKKKADKKGDKSARSPSSPSDYPEFAKQDGNAPRQDASPSAAPALDVQPKDPGVKREVKSESLPNEDTTQYEEPVLTKLIVESYEGEKVRGLYEGEGFAIFQGGCTYQGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGIFTWPDGSTYEGEVVGGMRHGFGMFKCSTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWIHNIRKGWGIRCYKSGNIYEGQWENNVRHGEGRMRWLTTNEEYTGQWKHGVQNGLGTHTWFLKRIPYSQYPLRNEYVGEFVNGYRHGHGKFYYASGAMYEGEWVSNKKHGMGRLTFKNGRVYDGPFSKDHMVAFPNLEGEVMSYPDSTSECAFGCQWCRPSASAEIMRKLDGNESNSLLGSSLELDLSLLLKMYPERDQSEEKKQVEYAILRNITELRRIYNFYSSLGCDRSLDNTFLMTKLHFWRFLKDCKFHHHNITLADMDRVLGANNDIPVEEIHSPFTTLLLRTFLNYLLQLAYHIHHKEYQDRSPSLFLCFKKLMNENIRPNACRVKGRLFCEAQRTLYSMTYVDKCWEIYTAHCRPNAAPPHELTMSTRHFLWMLRSFKIINKELTATKFVEVIAEDNPSMYDGIDSNFELELVFLEFFEALLSFALICVPEPPTKFCSDFPNDDLSVNKAGSTYPVTAQNTQNRSPSAVASQESDIQFSSTKSSSSKLGVLVDISKIRKSEPKIKKSVSDGTTSKVNFKSAGKGLTFLLSQSAHKHEETLKEKVKENRLHNEAMALQRKMENEELEARLNSLREEEAKRQDYEVDITVIKEPVDAPSSSFTPSPPKEDTVVSSKSITSKKKKK", "length": 840, "header": "sp|Q1JPG1-1|RS10B_BOVIN Isoform 1 of Radial spoke head 10 homolog B OS=Bos taurus OX=9913 GN=RSPH10B PE=2 SV=2 CANONICAL=Q1JPG1-1" }, "isoforms": [ { "isoform_ac": "Q1JPG1-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1/entry#Q1JPG1-1", "sequence": { "sequence": "MVKEKKKADKKGDKSARSPSSPSDYPEFAKQDGNAPRQDASPSAAPALDVQPKDPGVKREVKSESLPNEDTTQYEEPVLTKLIVESYEGEKVRGLYEGEGFAIFQGGCTYQGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGIFTWPDGSTYEGEVVGGMRHGFGMFKCSTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWIHNIRKGWGIRCYKSGNIYEGQWENNVRHGEGRMRWLTTNEEYTGQWKHGVQNGLGTHTWFLKRIPYSQYPLRNEYVGEFVNGYRHGHGKFYYASGAMYEGEWVSNKKHGMGRLTFKNGRVYDGPFSKDHMVAFPNLEGEVMSYPDSTSECAFGCQWCRPSASAEIMRKLDGNESNSLLGSSLELDLSLLLKMYPERDQSEEKKQVEYAILRNITELRRIYNFYSSLGCDRSLDNTFLMTKLHFWRFLKDCKFHHHNITLADMDRVLGANNDIPVEEIHSPFTTLLLRTFLNYLLQLAYHIHHKEYQDRSPSLFLCFKKLMNENIRPNACRVKGRLFCEAQRTLYSMTYVDKCWEIYTAHCRPNAAPPHELTMSTRHFLWMLRSFKIINKELTATKFVEVIAEDNPSMYDGIDSNFELELVFLEFFEALLSFALICVPEPPTKFCSDFPNDDLSVNKAGSTYPVTAQNTQNRSPSAVASQESDIQFSSTKSSSSKLGVLVDISKIRKSEPKIKKSVSDGTTSKVNFKSAGKGLTFLLSQSAHKHEETLKEKVKENRLHNEAMALQRKMENEELEARLNSLREEEAKRQDYEVDITVIKEPVDAPSSSFTPSPPKEDTVVSSKSITSKKKKK", "length": 840, "header": "sp|Q1JPG1-1|RS10B_BOVIN Isoform 1 of Radial spoke head 10 homolog B OS=Bos taurus OX=9913 GN=RSPH10B PE=2 SV=2 CANONICAL=Q1JPG1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "Q1JPG1", "url": "https://www.uniprot.org/uniprotkb/Q1JPG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 680, "end_pos": 682, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JPG1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 840, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JPG1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JPG1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 382, "end_pos": 384 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 680, "end_pos": 682 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JPH6-1", "uniprot_ac": "Q1JPH6", "uniprot_id": "IF4H_BOVIN", "mass": { "chemical_mass": 25219.0, "monoisotopic_mass": 25219.0 }, "refseq": { "ac": "NP_001069220", "name": "eukaryotic translation initiation factor 4H", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220" }, "gene_names": [ { "name": "EIF4H", "type": "recommended", "evidence": [ { "id": "Q1JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ] }, { "name": "EIF4H", "type": "synonym", "evidence": [ { "id": "NP_001069220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220" } ] }, { "name": "WBSCR1", "type": "synonym", "evidence": [ { "id": "NP_001069220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4H", "type": "recommended", "evidence": [ { "id": "Q1JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6/entry#names_and_taxonomy" } ] }, { "name": "eIF-4H", "type": "synonym", "evidence": [ { "id": "NP_001069220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220" }, { "id": "Q1JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 4H", "type": "synonym", "evidence": [ { "id": "NP_001069220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220" } ] } ], "function": [ { "annotation": "Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF4H", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6", "locus": { "chromosome": "25", "start_pos": 33197895, "end_pos": 33218949, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047249", "url": "https://www.ensembl.org/id/ENSBTAG00000047249" } ] } } ], "crossref": [ { "id": "Q1JPH6", "url": "https://alphafold.ebi.ac.uk/entry/Q1JPH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12401", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12401", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517409", "url": "https://www.ncbi.nlm.nih.gov/gene/517409", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034229", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034229", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517409", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517409", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1JPH6", "url": "https://www.orthodb.org/?gene=Q1JPH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069220", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPH6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGPNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVHKEQE", "length": 228, "header": "sp|Q1JPH6-1|IF4H_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4H OS=Bos taurus OX=9913 GN=EIF4H PE=2 SV=1 CANONICAL=Q1JPH6-1" }, "isoforms": [ { "isoform_ac": "Q1JPH6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6/entry#Q1JPH6-1", "sequence": { "sequence": "MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGPNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVHKEQE", "length": 228, "header": "sp|Q1JPH6-1|IF4H_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4H OS=Bos taurus OX=9913 GN=EIF4H PE=2 SV=1 CANONICAL=Q1JPH6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser13" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser14" }, { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser210" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser21" }, { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser24" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "site_lbl": "Ser32" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:517409", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517409", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q1JPH6", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JPH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 228, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JPH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JPH6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPH6" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 42, "end_pos": 118, "start_aa": "Tyr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 13, 14, 21, 24, 32, 210 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JPL0-1", "uniprot_ac": "Q1JPL0", "uniprot_id": "CMIP5_BOVIN", "mass": { "chemical_mass": 17301.0, "monoisotopic_mass": 17301.0 }, "refseq": { "ac": "NP_001068948", "name": "ciliary microtubule inner protein 5 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" }, "gene_names": [ { "name": "C11H2orf50", "type": "recommended", "evidence": [ { "id": "Q1JPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0" } ] }, { "name": "CIMIP5", "type": "recommended", "evidence": [ { "id": "Q1JPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0" } ] }, { "name": "C11H2orf50", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] }, { "name": "C2orf50", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] }, { "name": "CIMIP5", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] } ], "protein_names": [ { "name": "Ciliary microtubule inner protein 5", "type": "recommended", "evidence": [ { "id": "Q1JPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#names_and_taxonomy" } ] }, { "name": "ciliary microtubule inner protein 5 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] }, { "name": "ciliary microtubule inner protein 5", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] }, { "name": "uncharacterized protein C2orf50 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JPL0", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIMIP5", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0", "locus": {} } ], "crossref": [ { "id": "Q1JPL0", "url": "https://alphafold.ebi.ac.uk/entry/Q1JPL0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001903", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001903", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510955", "url": "https://www.ncbi.nlm.nih.gov/gene/510955", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DFFFMEG", "url": "https://omabrowser.org/oma/group/DFFFMEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1JPL0", "url": "https://www.orthodb.org/?gene=Q1JPL0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31909:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31909:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14945", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14945", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068948", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DHV6", "url": "https://www.uniprot.org/uniprotkb/A0A452DHV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHV6-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZK94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZK94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPL0", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPL0-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPL0-2", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JPL0-3", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWAQNWSFLKDYDPMGNKKEPVKLPDHVPRFSDTVPNSTNRAVGSRVDTPLGKTLIGLDFFFVEGARKKKLEEELQPI", "length": 157, "header": "sp|Q1JPL0-1|CMIP5_BOVIN Isoform 1 of Ciliary microtubule inner protein 5 OS=Bos taurus OX=9913 GN=CIMIP5 PE=2 SV=2 CANONICAL=Q1JPL0-1" }, "isoforms": [ { "isoform_ac": "A0A452DHV6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#A0A452DHV6-1", "sequence": { "sequence": "MRESSLSSGRSLSLSLTHTHSYTLAPMGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWAQNWSFLKDYDPMGNKKEPVKLPDHVPRFSDTVPNSTNRAVGSRVDTPLGKTLIGLDFFFVEGARKKKLEEELQPI", "length": 183, "header": "tr|A0A452DHV6-1|A0A452DHV6_BOVIN Computationally mapped isoform of Chromosome 11 C2orf50 homolog OS=Bos taurus OX=9913 GN=C11H2orf50 PE=4 SV=1 CANONICAL=Q1JPL0-1" }, "locus": { "chromosome": "11", "start_pos": 86651042, "end_pos": 86645965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002474.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002474.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002474.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002474.3" } ] } }, { "isoform_ac": "A0AAF6ZK94-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#A0AAF6ZK94-1", "sequence": { "sequence": "MRESSLSSGRSLSLSLTHTHSYTLAPMGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWATRRSP", "length": 113, "header": "tr|A0AAF6ZK94-1|A0AAF6ZK94_BOVIN Computationally mapped isoform of Chromosome 11 C2orf50 homolog OS=Bos taurus OX=9913 GN=C11H2orf50 PE=4 SV=1 CANONICAL=Q1JPL0-1" }, "locus": { "chromosome": "11", "start_pos": 86651042, "end_pos": 86646135, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055980.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055980.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051155.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051155.3" } ] } }, { "isoform_ac": "Q1JPL0-1", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#Q1JPL0-1", "sequence": { "sequence": "MGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWAQNWSFLKDYDPMGNKKEPVKLPDHVPRFSDTVPNSTNRAVGSRVDTPLGKTLIGLDFFFVEGARKKKLEEELQPI", "length": 157, "header": "sp|Q1JPL0-1|CMIP5_BOVIN Isoform 1 of Ciliary microtubule inner protein 5 OS=Bos taurus OX=9913 GN=CIMIP5 PE=2 SV=2 CANONICAL=Q1JPL0-1" }, "locus": {} }, { "isoform_ac": "Q1JPL0-2", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#Q1JPL0-2", "sequence": { "sequence": "MGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWAQNWSFLKDYDPMVRQTMLPSEMLALGVFIHAPHVY", "length": 117, "header": "sp|Q1JPL0-2|CMIP5_BOVIN Isoform 2 of Ciliary microtubule inner protein 5 OS=Bos taurus OX=9913 GN=CIMIP5 PE=2 SV=2 CANONICAL=Q1JPL0-1" }, "locus": {} }, { "isoform_ac": "Q1JPL0-3", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0/entry#Q1JPL0-3", "sequence": { "sequence": "MGSRPTPGLQRTTSAEYRLPSTRPPASVPSTAPGGPVVGRGPTGGPQAPKAKWSALGADGVQRDQLWRELLEAERRSQQRWATRRSP", "length": 87, "header": "sp|Q1JPL0-3|CMIP5_BOVIN Isoform 3 of Ciliary microtubule inner protein 5 OS=Bos taurus OX=9913 GN=CIMIP5 PE=2 SV=2 CANONICAL=Q1JPL0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 6, "start_aa": "Thr", "end_pos": 6, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr6", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q1JPL0", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510955", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510955", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QD69-1", "protein_name": "Uncharacterized protein C2orf50 homolog", "gene_name": "CUNH2orf50", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGSQHAGLPRATTSGHGLRPTRHLASVSRARDGPAASRGHAGGCQGATAPGVQQDQLWRELVEAEARGQQRWAENWGFLKDYDPLGNKKEPKELPTDMPFFSDTVPSSTSREVGSRLDTTLGRVLTQMDFFFMEGTRKRKPENELQPV", "length": 148 }, "evidence": [ { "id": "Q1JPL0", "url": "https://omabrowser.org/oma/group/Q1JPL0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B8JJ41-1", "protein_name": "Uncharacterized protein C2orf50 homolog", "gene_name": "cimip5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDRKGNVRRATSAGYRLPDRPNGPLASQSSVSVFRHSAGRTRNGETPAQNEDSRDPVKQDQVWREFVRAERSGVKEWEKNWSFLMNFDQLGHPRTETPLPNSVSLYSDRLPNTSNQMFGSSLYTELGNELVRLDNLLILTSNHRKAKRNPEMQPC", "length": 155 }, "evidence": [ { "id": "Q1JPL0", "url": "https://omabrowser.org/oma/group/Q1JPL0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3Z430-1", "protein_name": "Ciliary microtubule inner protein 5", "gene_name": "Cimip5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQHRGLPRTTSAGYKPPPTRQLASISAALGDGPAASRALAGGCQGTPALGVQQDQLWRELVEAEARGQRRWAENWGFLKDYDPLGNKKEPQELPASVPFFSDTFPCSTNREVGSRVDTPLGKALGHMDFFFVEGTRKRKPDDELQPV", "length": 149 }, "evidence": [ { "id": "Q1JPL0", "url": "https://omabrowser.org/oma/group/Q1JPL0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4A5F3-1", "protein_name": "Similar to human chromosome 2 open reading frame 50", "gene_name": "Cimip5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSQHTGLPRTTSSGYQLPPTRQLATISPGRDGPAAGRALVGGSQGTLAPGVQQDQLWRELVEAEARGQRRWAENWGFLKDYDPLRVTWDVSSPQGNKKEPQELPANVPFFSDTFPSSTSREVGSRVDTPLGRALSHMDFFFVEGTRKKKPEDELQPV", "length": 158 }, "evidence": [ { "id": "Q1JPL0", "url": "https://omabrowser.org/oma/group/Q1JPL0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96LR7-1", "protein_name": "Ciliary microtubule inner protein 5", "gene_name": "CIMIP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSHPTPGLQRTTSAGYRLPPTRPPASVSPAARGGPMASRGLAGGCQAPQALKAQRVAQGAACDGVQQDQLWRELLEAERRGQQRWIQNWSFLKDYDPMGNKKEPEKLPDHVPLFSDTVPSSTNQVVGSRLDTPLGQTLIRMDFFFTEGARKKKLEDQMQPI", "length": 162 }, "evidence": [ { "id": "Q1JPL0", "url": "https://omabrowser.org/oma/group/Q1JPL0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q1JPL0", "url": "https://www.uniprot.org/uniprotkb/Q1JPL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JPL0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 157, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JPL0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JPL0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 6, 43 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1JQ92-1", "uniprot_ac": "Q1JQ92", "uniprot_id": "POP5_BOVIN", "mass": { "chemical_mass": 19351.0, "monoisotopic_mass": 19351.0 }, "refseq": { "ac": "NP_001068780", "name": "ribonuclease P/MRP protein subunit POP5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068780" }, "gene_names": [ { "name": "POP5", "type": "recommended", "evidence": [ { "id": "Q1JQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ] }, { "name": "POP5", "type": "synonym", "evidence": [ { "id": "NP_001068780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068780" } ] } ], "protein_names": [ { "name": "Ribonuclease P/MRP protein subunit POP5", "type": "recommended", "evidence": [ { "id": "Q1JQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92/entry#names_and_taxonomy" } ] }, { "name": "processing of precursor 5, ribonuclease P/MRP subunit", "type": "synonym", "evidence": [ { "id": "NP_001068780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068780" } ] }, { "name": "ribonuclease P/MRP protein subunit POP5", "type": "synonym", "evidence": [ { "id": "NP_001068780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068780" } ] } ], "function": [ { "annotation": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92#function" }, { "database": "UniProtKB", "id": "Q969H6", "url": "https://www.uniprot.org/uniprotkb/Q969H6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POP5", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92", "locus": { "chromosome": "17", "start_pos": 62851538, "end_pos": 62853815, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005385", "url": "https://www.ensembl.org/id/ENSBTAG00000005385" } ] } } ], "crossref": [ { "id": "Q1JQ92", "url": "https://alphafold.ebi.ac.uk/entry/Q1JQ92", "database": "AlphaFoldDB", "categories": [] }, { "id": "507410", "url": "https://www.ncbi.nlm.nih.gov/gene/507410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507410", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507410", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1JQ92", "url": "https://www.orthodb.org/?gene=Q1JQ92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48414:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48414:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01900", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01900", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JQ92-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRFKHRYLLCEVVSDDPRCRLTLEDRVLGTLVRDTIARVHGTFGAAACSIGFAVRYLNAYTGIVLLRCRKEFYRLVWSALPFITSLENKGHRYPCFLNTLHVGGTIRTCQKFLIQYNRRQLLILLQNCTDEGEREAIQKSVTKSCLLEEESAGEELSDSGGEETAEPME", "length": 170, "header": "sp|Q1JQ92-1|POP5_BOVIN Isoform 1 of Ribonuclease P/MRP protein subunit POP5 OS=Bos taurus OX=9913 GN=POP5 PE=2 SV=1 CANONICAL=Q1JQ92-1" }, "isoforms": [ { "isoform_ac": "Q1JQ92-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92/entry#Q1JQ92-1", "sequence": { "sequence": "MVRFKHRYLLCEVVSDDPRCRLTLEDRVLGTLVRDTIARVHGTFGAAACSIGFAVRYLNAYTGIVLLRCRKEFYRLVWSALPFITSLENKGHRYPCFLNTLHVGGTIRTCQKFLIQYNRRQLLILLQNCTDEGEREAIQKSVTKSCLLEEESAGEELSDSGGEETAEPME", "length": 170, "header": "sp|Q1JQ92-1|POP5_BOVIN Isoform 1 of Ribonuclease P/MRP protein subunit POP5 OS=Bos taurus OX=9913 GN=POP5 PE=2 SV=1 CANONICAL=Q1JQ92-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "site_lbl": "Ser158" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "site_lbl": "Ser160" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507410", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507410", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "multimeric ribonuclease P complex", "id": "GO:0030681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030681", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" }, { "name": "ribonuclease MRP complex", "id": "GO:0000172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000172", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" }, { "name": "tRNA 5'-leader removal", "id": "GO:0001682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001682", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribonuclease P RNA binding", "id": "GO:0033204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033204", "evidence": [ { "database": "UniProtKB", "id": "Q1JQ92", "url": "https://www.uniprot.org/uniprotkb/Q1JQ92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JQ92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 170, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JQ92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JQ92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 158, 160 ], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1JQA8-1", "uniprot_ac": "Q1JQA8", "uniprot_id": "LYSM2_BOVIN", "mass": { "chemical_mass": 23382.0, "monoisotopic_mass": 23382.0 }, "refseq": { "ac": "NP_001068953", "name": "lysM and putative peptidoglycan-binding domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068953" }, "gene_names": [ { "name": "LYSMD2", "type": "recommended", "evidence": [ { "id": "Q1JQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ] }, { "name": "LYSMD2", "type": "synonym", "evidence": [ { "id": "NP_001068953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068953" } ] } ], "protein_names": [ { "name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q1JQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8/entry#names_and_taxonomy" } ] }, { "name": "LysM, putative peptidoglycan-binding, domain containing 2", "type": "synonym", "evidence": [ { "id": "NP_001068953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068953" } ] }, { "name": "lysM and putative peptidoglycan-binding domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001068953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068953" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYSMD2", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8", "locus": { "chromosome": "10", "start_pos": 58642428, "end_pos": 58628826, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017683", "url": "https://www.ensembl.org/id/ENSBTAG00000017683" } ] } } ], "crossref": [ { "id": "Q1JQA8", "url": "https://alphafold.ebi.ac.uk/entry/Q1JQA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017683", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017683", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00118", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00118", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511013", "url": "https://www.ncbi.nlm.nih.gov/gene/511013", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511013", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511013", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRMDVQI", "url": "https://omabrowser.org/oma/group/HRMDVQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1JQA8", "url": "https://www.orthodb.org/?gene=Q1JQA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01476", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01476", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068953", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JQA8-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSSPAPSLRAGGPREPRPSAPSPPPPHSRLGSEAEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVSMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSVDSPENETVDSFSHEEELVAAGEDVSPLSPQELDVQPMQPEEVSARDFLQRLDLQIKLSTQAAKKLKGESRDEEGLYTASLYHS", "length": 215, "header": "sp|Q1JQA8-1|LYSM2_BOVIN Isoform 1 of LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=LYSMD2 PE=2 SV=1 CANONICAL=Q1JQA8-1" }, "isoforms": [ { "isoform_ac": "Q1JQA8-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8/entry#Q1JQA8-1", "sequence": { "sequence": "MADSSPAPSLRAGGPREPRPSAPSPPPPHSRLGSEAEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVSMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSVDSPENETVDSFSHEEELVAAGEDVSPLSPQELDVQPMQPEEVSARDFLQRLDLQIKLSTQAAKKLKGESRDEEGLYTASLYHS", "length": 215, "header": "sp|Q1JQA8-1|LYSM2_BOVIN Isoform 1 of LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=LYSMD2 PE=2 SV=1 CANONICAL=Q1JQA8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ], "site_lbl": "Ser24" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ], "site_lbl": "Ser34" }, { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ], "site_lbl": "Ser58" }, { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQA8", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" } ], "site_lbl": "Ser5" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511013", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511013", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8XSR6-1", "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "gene_name": "Lysmd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGRGGCTVARSGFSRTLSRLHGSEVHMGSRTPPWASVGPQASARSRRAFSGRTRTLQPRLSSLIAISTGTSGAWEKLAQSGARHAGPAAPRLGLAPAAPAARPAAALVRRKRRRRRRRPLGELGAPAALAGPMADLSPAPALREGGPRAHRPSAPSPPLRSRSTSEPEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVTMEQIKRANKLFTNDCIFLKKTLSIPILSEKPLVFNGLNSIDSPESETVDSSFCHEEEPVVSEEELPPPSPQDTDPKPAQPEEVSARDFLQRLDLQIKLSTQAARKLKEENRDEESPYAASLYHS", "length": 348 }, "evidence": [ { "id": "Q1JQA8", "url": "https://omabrowser.org/oma/group/Q1JQA8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C5Q2-1", "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "gene_name": "LYSMD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAESPREEPPGGPESEAELSQRLALIKARSYGSTASVAAPLAERYVEHRLSAGDTLQGIALKYGVTMEQIKRANKLFTNDCIFLRKTLNIPVISEKPLLFNGLNSLESPENETVDSSPSCEEGLVTAQEESSSSPSPQEPDNQPTAPEELSAKDFLQRLDLQIKLSKQAARKLKDDSVREEENEEGPYATSSYHQ", "length": 195 }, "evidence": [ { "id": "Q1JQA8", "url": "https://omabrowser.org/oma/group/Q1JQA8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IV50-1", "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "gene_name": "LYSMD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSSPALSLREGGPRAPRPSAPSPPPRSRSGSESEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVTMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSIDSPENETADNSFSQEEEPVVAGEDLPPPSPQESDVQPVQPEEVSARDFLQRLDLQIKLSTQAAKKLKEESRDEESPYATSLYHS", "length": 215 }, "evidence": [ { "id": "Q1JQA8", "url": "https://omabrowser.org/oma/group/Q1JQA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7V2-1", "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "gene_name": "Lysmd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADLSPAPALREGGPRAHRPSAPSPPPRSRSTSEPEEAELSLSLARTKTRSYGSTASVRAPLGARVIERHVEHRVRAGDTLQGIALKYGVTMEQIKRANKLFTNDCIFLKKTLSIPILSEKPLLFNGLNSIDSPESETVDSSFCQEEEPVVSEEELPPPSPQDPDPKPAQPEEVSARDFLQRLDLQIKLSTQAARKLKEESRDEESPYAASLYHS", "length": 215 }, "evidence": [ { "id": "Q1JQA8", "url": "https://omabrowser.org/oma/group/Q1JQA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JQA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JQA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JQA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1JQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA8" }, { "id": "PRU01118", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LysM", "eco_id": "ECO_0000255", "start_pos": 72, "end_pos": 116, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 5, 24, 34, 58 ], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1JQE1-1", "uniprot_ac": "Q1JQE1", "uniprot_id": "TM219_BOVIN", "mass": { "chemical_mass": 25877.0, "monoisotopic_mass": 25877.0 }, "refseq": { "ac": "NP_001073700", "name": "insulin-like growth factor-binding protein 3 receptor isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700" }, "gene_names": [ { "name": "TMEM219", "type": "recommended", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1" } ] }, { "name": "IGFBP-3R", "type": "synonym", "evidence": [ { "id": "NP_001073700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700" } ] }, { "name": "TMEM219", "type": "synonym", "evidence": [ { "id": "NP_001073700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700" } ] } ], "protein_names": [ { "name": "Insulin-like growth factor-binding protein 3 receptor", "type": "recommended", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#names_and_taxonomy" } ] }, { "name": "IGFBP-3R", "type": "synonym", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 219", "type": "synonym", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#names_and_taxonomy" } ] }, { "name": "insulin-like growth factor-binding protein 3 receptor isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001073700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700" } ] }, { "name": "insulin-like growth factor-binding protein 3 receptor", "type": "synonym", "evidence": [ { "id": "NP_001073700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700" } ] } ], "function": [ { "annotation": "Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM219", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1", "locus": { "chromosome": "25", "start_pos": 26290035, "end_pos": 26342937, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021785", "url": "https://www.ensembl.org/id/ENSBTAG00000021785" } ] } } ], "crossref": [ { "id": "Q1JQE1", "url": "https://alphafold.ebi.ac.uk/entry/Q1JQE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021785", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021785", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506622", "url": "https://www.ncbi.nlm.nih.gov/gene/506622", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039493", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039493", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506622", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506622", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCYSLNF", "url": "https://omabrowser.org/oma/group/TCYSLNF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMB9", "url": "https://www.orthodb.org/?gene=A0A3Q1MMB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q1JQE1", "url": "https://www.orthodb.org/?gene=Q1JQE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16002:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16002:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14940", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14940", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803211", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001073700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073700", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATL3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JQE1-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 239, "header": "sp|Q1JQE1-1|TM219_BOVIN Isoform 1 of Insulin-like growth factor-binding protein 3 receptor OS=Bos taurus OX=9913 GN=TMEM219 PE=2 SV=1 CANONICAL=Q1JQE1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMB9-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0A3Q1MMB9-1", "sequence": { "sequence": "MGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSVWINFLGLDSELEEMLQKVESWNVGGNKRLFCSVFSGVLIGGWIEVGILG", "length": 245, "header": "tr|A0A3Q1MMB9-1|A0A3Q1MMB9_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=2 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26306815, "end_pos": 26291039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068496.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068496.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072271.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072271.2" } ] } }, { "isoform_ac": "A0AAA9SKL3-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAA9SKL3-1", "sequence": { "sequence": "MSGSSYHCSFYLDSSSPRTSHRKFIHIYILKASAQMSPPRKKRLFPEAQTPLLPMGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 293, "header": "tr|A0AAA9SKL3-1|A0AAA9SKL3_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26329945, "end_pos": 26292240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086876.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086876.1" } ] } }, { "isoform_ac": "A0AAA9T8G5-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAA9T8G5-1", "sequence": { "sequence": "MPLGLPPMPLSLLLTSRGVISFPLPLHWMFFWLFPEAQTPLLPMGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 282, "header": "tr|A0AAA9T8G5-1|A0AAA9T8G5_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26308145, "end_pos": 26292240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110227.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110227.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092907.1" } ] } }, { "isoform_ac": "A0AAA9TAM6-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAA9TAM6-1", "sequence": { "sequence": "MGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSVTGFPGAGWTRLAKWRRETVRRLLHTLPSDL", "length": 226, "header": "tr|A0AAA9TAM6-1|A0AAA9TAM6_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26306815, "end_pos": 26293026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119517.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119517.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093942.1" } ] } }, { "isoform_ac": "A0AAA9TS41-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAA9TS41-1", "sequence": { "sequence": "MGKCLLTGRLLSSSPFLSSRRLFPEAQTPLLPMGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSVWINFLGLDSELEEMLQKVESWNVGGNKRLFCSVFSGVLIGGWIEVGILG", "length": 277, "header": "tr|A0AAA9TS41-1|A0AAA9TS41_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26306911, "end_pos": 26291039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129924.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129924.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101197.1" } ] } }, { "isoform_ac": "A0AAF6ZA02-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAF6ZA02-1", "sequence": { "sequence": "MGKCLLTGRLLSSSPFLSSRRLFPEAQTPLLPMGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 271, "header": "tr|A0AAF6ZA02-1|A0AAF6ZA02_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26306911, "end_pos": 26292240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029038.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029038.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029038.4", "url": "https://www.ensembl.org/id/ENSBTAP00000029038.4" } ] } }, { "isoform_ac": "A0AAF7ATL3-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#A0AAF7ATL3-1", "sequence": { "sequence": "MAGRLFPEAQTPLLPMGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 254, "header": "tr|A0AAF7ATL3-1|A0AAF7ATL3_BOVIN Computationally mapped isoform of Transmembrane protein 219 OS=Bos taurus OX=9913 GN=TMEM219 PE=4 SV=1 CANONICAL=Q1JQE1-1" }, "locus": { "chromosome": "25", "start_pos": 26341185, "end_pos": 26292240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074830.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074830.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074543.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074543.2" } ] } }, { "isoform_ac": "Q1JQE1-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1/entry#Q1JQE1-1", "sequence": { "sequence": "MGSCQAGHYLHFCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHRTDLRSPDIPQDWVSFLRSFGQLTLCPVNGTVTGKGRGSHIVGLLTTLNFGDGPDRNKTQTFQAQVQGSRMGLKGSFARELVLVTARVTTERTPGTCLYFSAIPEILPSSQPPIPCSEEGAGNATLSPRMSEECVGVWSHEGLVLTKLLTSEELTLCGSRLLVLGFFLILFCGLCCLTAACFHPRRESHWSRTRL", "length": 239, "header": "sp|Q1JQE1-1|TM219_BOVIN Isoform 1 of Insulin-like growth factor-binding protein 3 receptor OS=Bos taurus OX=9913 GN=TMEM219 PE=2 SV=1 CANONICAL=Q1JQE1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 101, "start_aa": "Asn", "end_pos": 101, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn101", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q1JQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506622", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506622", "resource": "KEGG Pathway" }, { "id": "R-BTA-6803211", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803211", "resource": "Reactome", "description": "TP53 Regulates Transcription of Death Receptors and Ligands" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AG17-1", "protein_name": "Transmembrane protein 219", "gene_name": "Tmem219", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRVWTDWGGAVAGARARAGPAPRRAAHDVTGRRSPPGCKRRHSTEAQTPLLPMGSCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHTTGLRSPDIPQDWVTFLRSFGQLSLCPMNETVTGKWQGPHVVGLLTTLNFGGDPDRNKTQTFQAMIPGSQIGFKEIAGESVLVTARVASGRTPGTCLYFSGIPKILPSSQPPISCSEEGAGNATLSPMMGEECVIVWSHERFVLTKLLTSEELALCGSRLLVLGSFLVLLCGFLCCATAACFHPRPEFHWSRARL", "length": 291 }, "evidence": [ { "id": "Q1JQE1", "url": "https://omabrowser.org/oma/group/Q1JQE1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I4I4-1", "protein_name": "Insulin-like growth factor-binding protein 3 receptor isoform X1", "gene_name": "Tmem219", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEGLLICRLLSSSPSLSSSRWSTEAQTPLLPMGSCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHTSGLRSPDIPQDWVSFLRSFGQLSLCPVNGTVAGKWRGPHVVGLLTTLNFGDASDRNKTQTFQANVHGSQIGLKGSSAGESILITARVASGRTPETCLYFSAVPEILPSSQPPISCSEEGAENATLSPVMGEECVRVWSLERFVLTKLLTSEELALCGTRLLVLGSFLLLFCGFLCCVTAVCFHPRPESHRSRTRL", "length": 272 }, "evidence": [ { "id": "Q1JQE1", "url": "https://omabrowser.org/oma/group/Q1JQE1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q86XT9-1", "protein_name": "Insulin-like growth factor-binding protein 3 receptor", "gene_name": "TMEM219", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL", "length": 240 }, "evidence": [ { "id": "Q1JQE1", "url": "https://omabrowser.org/oma/group/Q1JQE1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D123-1", "protein_name": "Insulin-like growth factor-binding protein 3 receptor", "gene_name": "Tmem219", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGGFLLTHTTGLRSPDIPQDWVSFLRSFGQLSLCPMNETVTGTWQGPHVVGLLTTLNFGDGPDRNKTQTFQAKIHGSQIGLTGSSAGESVLVTARVASGRTPGTCLYFSGVPKVLPSSQPPISCSEEGVGNATLSPVMGEECVRVWSHERLVLTELLTSEELALCGSRVLGLGFFLVLLCGLLCCTTAVCFHPRPEFHWSRTRL", "length": 240 }, "evidence": [ { "id": "Q1JQE1", "url": "https://omabrowser.org/oma/group/Q1JQE1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JQE1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 239, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JQE1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JQE1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 101, 167 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1JQE2-1", "uniprot_ac": "Q1JQE2", "uniprot_id": "S7A6O_BOVIN", "mass": { "chemical_mass": 34762.0, "monoisotopic_mass": 34762.0 }, "refseq": { "ac": "NP_001069035", "name": "probable RNA polymerase II nuclear localization protein SLC7A6OS", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035" }, "gene_names": [ { "name": "SLC7A6OS", "type": "recommended", "evidence": [ { "id": "Q1JQE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ] }, { "name": "SLC7A6OS", "type": "synonym", "evidence": [ { "id": "NP_001069035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035" } ] } ], "protein_names": [ { "name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "type": "recommended", "evidence": [ { "id": "Q1JQE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 7 member 6 opposite strand transcript homolog", "type": "synonym", "evidence": [ { "id": "Q1JQE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2/entry#names_and_taxonomy" } ] }, { "name": "probable RNA polymerase II nuclear localization protein SLC7A6OS", "type": "synonym", "evidence": [ { "id": "NP_001069035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035" } ] }, { "name": "protein SLC7A6OS", "type": "synonym", "evidence": [ { "id": "NP_001069035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035" } ] }, { "name": "solute carrier family 7 member 6 opposite strand transcript homolog", "type": "synonym", "evidence": [ { "id": "NP_001069035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035" } ] } ], "function": [ { "annotation": "Directs RNA polymerase II nuclear import.", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC7A6OS", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2", "locus": { "chromosome": "18", "start_pos": 35672589, "end_pos": 35680832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009636", "url": "https://www.ensembl.org/id/ENSBTAG00000009636" } ] } } ], "crossref": [ { "id": "Q1JQE2", "url": "https://alphafold.ebi.ac.uk/entry/Q1JQE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009636", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009636", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512543", "url": "https://www.ncbi.nlm.nih.gov/gene/512543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040218", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040218", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512543", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512543", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QMWSKYP", "url": "https://omabrowser.org/oma/group/QMWSKYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1JQE2", "url": "https://www.orthodb.org/?gene=Q1JQE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31196:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31196:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069035", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1JQE2-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAGRTAVLRVKRKLGTEPAEALVLACKRLRSSAVELETPKTSPEGLERAAENNVFQLVATVRSQEEPVQPLLRAALRPSQGSQQRIRHHLRASAREIRQEGRYRVVFSRRSSGIPSDSLESEDASGTAKAADDANFQLLDLVHEEDAEVAAAAISCKKSDPDVILCNCVELIREGLNVSQCGPSSGHQKEQKDDFVYDIYCLERATPGWIENILSVQPYSHEWELVNDDQQPEDIYDDEDDENSENNWRNEYPEEENSDEDEDSRGSDNYSSSEERDNSRQPMWSKYPLDVQKEFDYDSPHDLDSD", "length": 307, "header": "sp|Q1JQE2-1|S7A6O_BOVIN Isoform 1 of Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Bos taurus OX=9913 GN=SLC7A6OS PE=2 SV=1 CANONICAL=Q1JQE2-1" }, "isoforms": [ { "isoform_ac": "Q1JQE2-1", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2/entry#Q1JQE2-1", "sequence": { "sequence": "MEAGRTAVLRVKRKLGTEPAEALVLACKRLRSSAVELETPKTSPEGLERAAENNVFQLVATVRSQEEPVQPLLRAALRPSQGSQQRIRHHLRASAREIRQEGRYRVVFSRRSSGIPSDSLESEDASGTAKAADDANFQLLDLVHEEDAEVAAAAISCKKSDPDVILCNCVELIREGLNVSQCGPSSGHQKEQKDDFVYDIYCLERATPGWIENILSVQPYSHEWELVNDDQQPEDIYDDEDDENSENNWRNEYPEEENSDEDEDSRGSDNYSSSEERDNSRQPMWSKYPLDVQKEFDYDSPHDLDSD", "length": 307, "header": "sp|Q1JQE2-1|S7A6O_BOVIN Isoform 1 of Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Bos taurus OX=9913 GN=SLC7A6OS PE=2 SV=1 CANONICAL=Q1JQE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 300, "end_pos": 300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "site_lbl": "Ser300" }, { "start_pos": 306, "end_pos": 306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "site_lbl": "Ser306" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512543", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512543", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UF84-1", "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "SLC7A6OS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAGRTAVLRVKRKRSAEPAEALVLACKRLRSSAVESGVQKTPPDGLESAAENNVFQLVATLRSQEEPVQPLLRAALRPSQSSQQRIRSHLRASAQEMRQEGRYRVVSSHRSSGIPSGGLESEDAPGSPEATAEDAGFQLLDLVREEEDPEAANATISRKTSDPDVILCNSVELIRERLTISEDGPKVEHQEEQKDDYVYDIYYLDMATPGWIENILSVQPYSQEWELVNDDQQPEDIYEDEDDENSENNWRNEYPEEENSDGDEDSRGSDDYNSLSEEERDNSSPQRWSKYPLDVQKEFGYDGPHDLDSD", "length": 311 }, "evidence": [ { "id": "Q1JQE2", "url": "https://omabrowser.org/oma/group/Q1JQE2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V8N8-1", "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "Slc7a6os", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAGRTAVLRVKRKRNAEPAEALVLACKRLRSGEVESSAPETPEGQETGAERNVFQLVATVRSQEPIQQLVRAALRPSRSSQLRIRRDLRASVREVRKEGRYRVVSSHRSSGTSNSLEPQCVSEAVRDGGFQLLDLVHEEEDPEAAATDCRKTSDPDVILCNSVELIRERLTVSEDGSQVEHQEEPKHSDDYVYDIYYMEMAPPGWIENILSVQPYSQEWELVNDDEQPEDIYEDEDDENSENNWRNEYPDEESSDRDEDSRGSDEYNSLSDEERSCRRLVWSKYPLDVQKEFGYDSPHDLDSD", "length": 304 }, "evidence": [ { "id": "Q1JQE2", "url": "https://omabrowser.org/oma/group/Q1JQE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5U3I2-1", "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "slc7a6os", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPSTTILRVKRKRGTDPADALLLACKRIRPEATAAQPSDESEPEPQEPKIENSVFKLVATVVSQDAPVQPHVREALARPRLAHHALRPSQGSSQRIIGDLRSVKWSTRREERYRILSSHRAGLPSEPAPAGGGGEENHDSHAESRDGLPLGEVQVFDILHEEEDVKVPGKMVVSDPETILCNSVKMIREKLSVSGAGLGTEHREKEDDYVYDLYYQETATPGWIQDILSVRPYSQEGELVPDEVAWEEEVYEDEDDENAEANWRNDYPEESSEGDSEGEERYGGCWSEEHSYSRRSRECYRRDMIDELENDKDEDDEEREYNDSD", "length": 326 }, "evidence": [ { "id": "Q1JQE2", "url": "https://omabrowser.org/oma/group/Q1JQE2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7TPE5-1", "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "Slc7a6os", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAGRTAVLRVKRKRNAEPAEALVLACKRPRSSEVESAARETPEGQEAAAAERNVFQLVATVRSQEEPIQQLVRAALRPSRSSQLRIRRDLRASVREVRKEGRYRVVSSHRSSGTSNSLEPQCGSEAVGDAGFQLLDLVHEEENPEAAATDCRKTSDPDVILCNSVELIRERLTVSEDGSQVNHQEDPKHNDDYVYDIYYMEMAPPGWIENIMSVQPYSQEWELVNDDEQSEDIYEDEDDENSENNWRNEYPDEESSDRDEDSRGSDEYNSLSEEERSCERLMWSKYPLDVQKEFDYDSPHGLDSD", "length": 306 }, "evidence": [ { "id": "Q1JQE2", "url": "https://omabrowser.org/oma/group/Q1JQE2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CW6-1", "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "SLC7A6OS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAARTAVLRVKRKRSAEPAEALVLACKRLRSDAVESAAQKTSEGLERAAENNVFHLVATVCSQEEPVQPLLREVLRPSRDSQQRVRRNLRASAREVRQEGRYRVLSSRRSLGTTSSGQESEYTPGNPEAAGNSGFQLLDLVHEEGEPEAASAGSCKTSDPDVILCNSVELIRERLTVSEDGPGVRRQEEQKHDDYVYDIYYLETATPGWIENILSVQPYSQEWELVNDDQEPEDIYDDEDDENSENNWRNEYPEEESSDGDEDSRGSADYNSLSEEERGSSRQRMWSKYPLDVQKEFGYDSPHDLDSD", "length": 309 }, "evidence": [ { "id": "Q1JQE2", "url": "https://omabrowser.org/oma/group/Q1JQE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "pmid": "" }, { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "Q1JQE2", "url": "https://www.uniprot.org/uniprotkb/Q1JQE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1JQE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1JQE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1JQE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 300, 306 ], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 270, "end_pos": 272 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1LZ79-1", "uniprot_ac": "Q1LZ79", "uniprot_id": "GEMI8_BOVIN", "mass": { "chemical_mass": 26744.0, "monoisotopic_mass": 26744.0 }, "refseq": { "ac": "NP_001069199", "name": "gem-associated protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069199" }, "gene_names": [ { "name": "GEMIN8", "type": "recommended", "evidence": [ { "id": "Q1LZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ] }, { "name": "GEMIN8", "type": "synonym", "evidence": [ { "id": "NP_001069199", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069199" } ] } ], "protein_names": [ { "name": "Gem-associated protein 8", "type": "recommended", "evidence": [ { "id": "Q1LZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79/entry#names_and_taxonomy" } ] }, { "name": "Gemin-8", "type": "synonym", "evidence": [ { "id": "Q1LZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79/entry#names_and_taxonomy" } ] }, { "name": "gem-associated protein 8", "type": "synonym", "evidence": [ { "id": "NP_001069199", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069199" } ] }, { "name": "gemin-8", "type": "synonym", "evidence": [ { "id": "NP_001069199", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069199" } ] } ], "function": [ { "annotation": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79#function" }, { "database": "UniProtKB", "id": "Q9NWZ8", "url": "https://www.uniprot.org/uniprotkb/Q9NWZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GEMIN8", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79", "locus": { "chromosome": "X", "start_pos": 129507145, "end_pos": 129489746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010289", "url": "https://www.ensembl.org/id/ENSBTAG00000010289" } ] } } ], "crossref": [ { "id": "Q1LZ79", "url": "https://alphafold.ebi.ac.uk/entry/Q1LZ79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010289", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010289", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515968", "url": "https://www.ncbi.nlm.nih.gov/gene/515968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR034754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515968", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515968", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYFAHTE", "url": "https://omabrowser.org/oma/group/QYFAHTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1LZ79", "url": "https://www.orthodb.org/?gene=Q1LZ79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16238", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16238", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16238:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16238:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069199", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1LZ79-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAKSESTQASESWSSHPVYARYWQHYHQAMAWMRSHQSAYQKAVESVVTSPWYYPATDLAQSPAAKGGTSPKSRSKSPSASGDACRRRSRPGKPGPQRRSTEKPARFAEDNDSESDDCGIVCDLSNMVITDELRQYFAETEQHREELRRQHQLDAARLKDYVNADHGLYCDKRGRSTLPPTERPGERRQAEMKRLYGASAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKF", "length": 234, "header": "sp|Q1LZ79-1|GEMI8_BOVIN Isoform 1 of Gem-associated protein 8 OS=Bos taurus OX=9913 GN=GEMIN8 PE=2 SV=1 CANONICAL=Q1LZ79-1" }, "isoforms": [ { "isoform_ac": "Q1LZ79-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79/entry#Q1LZ79-1", "sequence": { "sequence": "MEAKSESTQASESWSSHPVYARYWQHYHQAMAWMRSHQSAYQKAVESVVTSPWYYPATDLAQSPAAKGGTSPKSRSKSPSASGDACRRRSRPGKPGPQRRSTEKPARFAEDNDSESDDCGIVCDLSNMVITDELRQYFAETEQHREELRRQHQLDAARLKDYVNADHGLYCDKRGRSTLPPTERPGERRQAEMKRLYGASAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKF", "length": 234, "header": "sp|Q1LZ79-1|GEMI8_BOVIN Isoform 1 of Gem-associated protein 8 OS=Bos taurus OX=9913 GN=GEMIN8 PE=2 SV=1 CANONICAL=Q1LZ79-1" }, "locus": { "chromosome": "X", "start_pos": 129506854, "end_pos": 129496615, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013582.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013582.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013582.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013582.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515968", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515968", "resource": "KEGG Pathway" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LWK8-1", "protein_name": "Gem-associated protein 8", "gene_name": "Gemin8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSKWRTTASWYSHPVYARYWRHYHHAMAWMQSHQRAYKKSRDSYFTSPWFSPYGVLPWSSLDYEAGHPWNYQGQHMAWQESPYNVSHLKSSGQPLYSNSRTQTSAREYEAPQEEEEIESDSDNEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDDYVNADHGLYYNHHRSVEPPSEKPGERRQAEMKRLYGDSAPKILAMEAAVQLSFDKYCDKKQPKYWPVIPLKF", "length": 238 }, "evidence": [ { "id": "Q1LZ79", "url": "https://omabrowser.org/oma/group/Q1LZ79/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X5C0-1", "protein_name": "Gem nuclear organelle associated protein 8", "gene_name": "GEMIN8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQTPQEMEETEPWYSQKMYARYWKHYDLAMRWMHRHQEAYRKAMESFYHVPWPPYAASPSRRYSDWDGDDPPCTHNRFSNYSPRGRAQQYMDAQPGKEDDDREEEEEDSEVEEDSESEGEFEYDLSNMEITEELRQFFAQTERHREELRFTLQCTVPMMQFWEPTFVAGRQQQLEAEQQEMYVEADQDLYRNMKRSVEPPAERPGERRVAEMEKLYGDEAAKILAMETAMQLIFDRNCDKKQPKYWPIIPLKL", "length": 254 }, "evidence": [ { "id": "Q1LZ79", "url": "https://omabrowser.org/oma/group/Q1LZ79/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SQV2-1", "protein_name": "Gem nuclear organelle associated protein 8", "gene_name": "GEMIN8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAETAPGQAPESWCSHPVYARYWHHYHQAMAWMRSHQSTYRKAVESFFSSPWYFPPAGLAQGAYAQEGGSPWPDSEQPPAPGGSCHQYPHAGGPEPGPRGREEPAWSAEEEEEEQEEESESDDGGIECDLSNMEITEELRQYFAQTERHREERRRQQQLDAARLDDYVNADHDLYCDTRRSALPPAERPGERRAAEMRRLYGASAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF", "length": 239 }, "evidence": [ { "id": "Q1LZ79", "url": "https://omabrowser.org/oma/group/Q1LZ79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BHE1-1", "protein_name": "Gem-associated protein 8", "gene_name": "Gemin8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASNWRASASWYSHPVYARYWQHYHHAMLWMQGHQNAYRKFRDSYFTSPWLFPHGALPWNSPAYEAGHPWDSQGQHMAQQESPYRVSHPKSPGQPLRNSSRTQASTRGNEARCEEEELESDSDDEVECDLSNMEITEELRQYFAQTERHREERRRQQQLDAERLNDYVNADHGLYFNHRRSLEPPSEKPWERRQAEMKRLYGNSAPKILAMETAVQLSFDKHCDRKQPKYWPVIPLKF", "length": 238 }, "evidence": [ { "id": "Q1LZ79", "url": "https://omabrowser.org/oma/group/Q1LZ79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWZ8-1", "protein_name": "Gem-associated protein 8", "gene_name": "GEMIN8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHFRRSGQHPRYSSRIQASTKEDQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYVNADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF", "length": 242 }, "evidence": [ { "id": "Q1LZ79", "url": "https://omabrowser.org/oma/group/Q1LZ79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "pmid": "" }, { "name": "SMN complex", "id": "GO:0032797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032797", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "pmid": "" }, { "name": "SMN-Sm protein complex", "id": "GO:0034719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034719", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "pmid": "" }, { "name": "Gemini of Cajal bodies", "id": "GO:0097504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097504", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spliceosomal snRNP assembly", "id": "GO:0000387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000387", "evidence": [ { "database": "UniProtKB", "id": "Q1LZ79", "url": "https://www.uniprot.org/uniprotkb/Q1LZ79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1LZ79-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1LZ79-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1LZ79" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1LZB5-1", "uniprot_ac": "Q1LZB5", "uniprot_id": "TOM40_BOVIN", "mass": { "chemical_mass": 37725.0, "monoisotopic_mass": 37725.0 }, "refseq": { "ac": "NP_001068906", "name": "mitochondrial import receptor subunit TOM40 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" }, "gene_names": [ { "name": "TOMM40", "type": "recommended", "evidence": [ { "id": "Q1LZB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ] }, { "name": "TOMM40", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] }, { "name": "Tom40A", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] } ], "protein_names": [ { "name": "Mitochondrial import receptor subunit TOM40 homolog", "type": "recommended", "evidence": [ { "id": "Q1LZB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5/entry#names_and_taxonomy" } ] }, { "name": "Translocase of outer membrane 40 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "Q1LZB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import receptor subunit TOM40 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] }, { "name": "translocase of outer membrane 40 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] }, { "name": "translocase of outer mitochondrial membrane 40 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] }, { "name": "translocase of outer mitochondrial membrane 40A", "type": "synonym", "evidence": [ { "id": "NP_001068906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ] } ], "function": [ { "annotation": "Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5#function" }, { "database": "UniProtKB", "id": "O96008", "url": "https://www.uniprot.org/uniprotkb/O96008#function" } ] }, { "annotation": "Data demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.", "evidence": [ { "database": "RefSeq", "id": "NP_001068906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" }, { "database": "PubMed", "id": "20109159", "url": "https://glygen.org/publication/PubMed/20109159" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM40", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5", "locus": { "chromosome": "18", "start_pos": 52630578, "end_pos": 52619205, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001781", "url": "https://www.ensembl.org/id/ENSBTAG00000001781" } ] } } ], "crossref": [ { "id": "Q1LZB5", "url": "https://alphafold.ebi.ac.uk/entry/Q1LZB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001781", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001781", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07305", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07305", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510219", "url": "https://www.ncbi.nlm.nih.gov/gene/510219", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR023614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510219", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510219", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRFNYRW", "url": "https://omabrowser.org/oma/group/TRFNYRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1LZB5", "url": "https://www.orthodb.org/?gene=Q1LZB5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10802", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10802", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01459", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01459", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5205685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NWW5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWW5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1LZB5-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNVLAASSPPAGPPPPPAPPLVGLPPPPPSPPGFTLPPLGGGLGAGAGTGRGSERTPGTAAASAGGTADDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGAVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG", "length": 361, "header": "sp|Q1LZB5-1|TOM40_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM40 homolog OS=Bos taurus OX=9913 GN=TOMM40 PE=2 SV=1 CANONICAL=Q1LZB5-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NWW5-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5/entry#A0ABI0NWW5-1", "sequence": { "sequence": "MGNVLAASSPPAGPPPPPAPPLVGLPPPPPSPPGFTLPPLGGGLGAGAGTGRGSERTPGTAAASAGGTADDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGAVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGTGLPFLMETSKR", "length": 328, "header": "tr|A0ABI0NWW5-1|A0ABI0NWW5_BOVIN Computationally mapped isoform of Translocase of outer mitochondrial membrane 40 OS=Bos taurus OX=9913 GN=TOMM40 PE=3 SV=1 CANONICAL=Q1LZB5-1" }, "locus": { "chromosome": "18", "start_pos": 52628836, "end_pos": 52619375, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149976.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149976.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105606.1" } ] } }, { "isoform_ac": "Q1LZB5-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5/entry#Q1LZB5-1", "sequence": { "sequence": "MGNVLAASSPPAGPPPPPAPPLVGLPPPPPSPPGFTLPPLGGGLGAGAGTGRGSERTPGTAAASAGGTADDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGAVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG", "length": 361, "header": "sp|Q1LZB5-1|TOM40_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM40 homolog OS=Bos taurus OX=9913 GN=TOMM40 PE=2 SV=1 CANONICAL=Q1LZB5-1" }, "locus": { "chromosome": "18", "start_pos": 52630066, "end_pos": 52619375, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032251.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032251.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032188.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032188.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells.", "journal": "Cellular microbiology", "date": "2010-07", "authors": "Kisiela Dagmara I, Aulik Nicole A, Atapattu Dhammika N, Czuprynski Charles J", "evidence": [ { "database": "RefSeq", "id": "NP_001068906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068906" } ], "reference": [ { "type": "PubMed", "id": "20109159", "url": "https://glygen.org/publication/PubMed/20109159" } ] } ], "pathway": [ { "id": "bta:510219", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510219", "resource": "KEGG Pathway" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "O96008-1", "protein_name": "Mitochondrial import receptor subunit TOM40 homolog", "gene_name": "TOMM40", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG", "length": 361 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P23644-1", "protein_name": "Mitochondrial import receptor subunit TOM40", "gene_name": "TOM40", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSAPTPLAEASQIPTIPALSPLTAKQSKGNFFSSNPISSFVVDTYKQLHSHRQSLELVNPGTVENLNKEVSRDVFLSQYFFTGLRADLNKAFSMNPAFQTSHTFSIGSQALPKYAFSALFANDNLFAQGNIDNDLSVSGRLNYGWDKKNISKVNLQISDGQPTMCQLEQDYQASDFSVNVKTLNPSFSEKGEFTGVAVASFLQSVTPQLALGLETLYSRTDGSAPGDAGVSYLTRYVSKKQDWIFSGQLQANGALIASLWRKVAQNVEAGIETTLQAGMVPITDPLMGTPIGIQPTVEGSTTIGAKYEYRQSVYRGTLDSNGKVACFLERKVLPTLSVLFCGEIDHFKNDTKIGCGLQFETAGNQELLMLQQGLDADGNPLQALPQL", "length": 387 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q75Q40-1", "protein_name": "Mitochondrial import receptor subunit TOM40 homolog", "gene_name": "Tomm40", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSNAGRGSERTPGAAASGAAASSNDGNCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEKGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG", "length": 361 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9LHE5-1", "protein_name": "Mitochondrial import receptor subunit TOM40-1", "gene_name": "TOM40-1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADLLPPLTAAQVDAKTKVDEKVDYSNLPSPVPYEELHREALMSLKSDNFEGLRFDFTRALNQKFSLSHSVMMGPTEVPAQSPETTIKIPTAHYEFGANYYDPKLLLIGRVMTDGRLNARLKADLTDKLVVKANALITNEEHMSQAMFNFDYMGSDYRAQLQLGQSALIGATYIQSVTNHLSLGGEIFWAGVPRKSGIGYAARYETDKMVASGQVASTGAVVMNYVQKISDKVSLATDFMYNYFSRDVTASVGYDYMLRQARVRGKIDSNGVASALLEERLSMGLNFLLSAELDHKKKDYKFGFGLTVG", "length": 309 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9QYA2-1", "protein_name": "Mitochondrial import receptor subunit TOM40 homolog", "gene_name": "Tomm40", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG", "length": 361 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9U4L6-1", "protein_name": "Mitochondrial import receptor subunit TOM40 homolog 1", "gene_name": "Tom40", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGNVLAASSGAPGSGASNLGLGLQEPAPLPSNSGSLTESSSSAEGLDSLAAAKDAALENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGYRFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDYRGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGTLGQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSNWQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG", "length": 344 }, "evidence": [ { "id": "Q1LZB5", "url": "https://omabrowser.org/oma/group/Q1LZB5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" }, { "name": "mitochondrial outer membrane translocase complex", "id": "GO:0005742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005742", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein targeting to mitochondrion", "id": "GO:0006626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006626", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "Q1LZB5", "url": "https://www.uniprot.org/uniprotkb/Q1LZB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1LZB5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1LZB5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1LZB5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1LZD1-1", "uniprot_ac": "Q1LZD1", "uniprot_id": "TM102_BOVIN", "mass": { "chemical_mass": 54641.0, "monoisotopic_mass": 54641.0 }, "refseq": { "ac": "NP_001068812", "name": "transmembrane protein 102", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068812" }, "gene_names": [ { "name": "TMEM102", "type": "recommended", "evidence": [ { "id": "Q1LZD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ] }, { "name": "TMEM102", "type": "synonym", "evidence": [ { "id": "NP_001068812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068812" } ] } ], "protein_names": [ { "name": "Transmembrane protein 102", "type": "recommended", "evidence": [ { "id": "Q1LZD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 102", "type": "synonym", "evidence": [ { "id": "NP_001068812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068812" } ] } ], "function": [ { "annotation": "Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM102", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1", "locus": { "chromosome": "19", "start_pos": 27114381, "end_pos": 27112307, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031737", "url": "https://www.ensembl.org/id/ENSBTAG00000031737" } ] } } ], "crossref": [ { "id": "Q1LZD1", "url": "https://alphafold.ebi.ac.uk/entry/Q1LZD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031737", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031737", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508014", "url": "https://www.ncbi.nlm.nih.gov/gene/508014", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508014", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508014", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAPWWGP", "url": "https://omabrowser.org/oma/group/GAPWWGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1LZD1", "url": "https://www.orthodb.org/?gene=Q1LZD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001068812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068812", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1LZD1-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAVWGNAPWWSPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWNDGPKPGPDLLQAKDFVFSLLSLIHRRDPRFPPQTELLLLRGGIREGSLDLGPAPLGPYTRGPHYDAGFTLLVPVFSLDGTGQELQLDMRSCYAWLCLPEQVRGTSVREAWQDCLGPPVPGGRDWIHPTDSREGPRDPQSSVDQPHSDIIEPEAHESLEKSPSNVSVPESPQQNLTDIGFPSLSEETNDDVTKAADVSPGPQPSEAREAWPTLCPAQVAAWFFASLAAVAESLFPVPGAPRLVHAARHAGFTTILLATPGPPRRLLLFDLIPVVSVAGWPQGARSHSWAGPLASESSSFYLVPGGGGQTERPGASGWQLCFARQELALKARIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEARTLPHYFLSGQKLRAGDGASSLLGALALLRGDPARALRAAVEEAKAARKGGGLAGVGAGSH", "length": 512, "header": "sp|Q1LZD1-1|TM102_BOVIN Isoform 1 of Transmembrane protein 102 OS=Bos taurus OX=9913 GN=TMEM102 PE=2 SV=1 CANONICAL=Q1LZD1-1" }, "isoforms": [ { "isoform_ac": "Q1LZD1-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1/entry#Q1LZD1-1", "sequence": { "sequence": "MASAVWGNAPWWSPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWNDGPKPGPDLLQAKDFVFSLLSLIHRRDPRFPPQTELLLLRGGIREGSLDLGPAPLGPYTRGPHYDAGFTLLVPVFSLDGTGQELQLDMRSCYAWLCLPEQVRGTSVREAWQDCLGPPVPGGRDWIHPTDSREGPRDPQSSVDQPHSDIIEPEAHESLEKSPSNVSVPESPQQNLTDIGFPSLSEETNDDVTKAADVSPGPQPSEAREAWPTLCPAQVAAWFFASLAAVAESLFPVPGAPRLVHAARHAGFTTILLATPGPPRRLLLFDLIPVVSVAGWPQGARSHSWAGPLASESSSFYLVPGGGGQTERPGASGWQLCFARQELALKARIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEARTLPHYFLSGQKLRAGDGASSLLGALALLRGDPARALRAAVEEAKAARKGGGLAGVGAGSH", "length": 512, "header": "sp|Q1LZD1-1|TM102_BOVIN Isoform 1 of Transmembrane protein 102 OS=Bos taurus OX=9913 GN=TMEM102 PE=2 SV=1 CANONICAL=Q1LZD1-1" }, "locus": { "chromosome": "19", "start_pos": 27114365, "end_pos": 27112743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025621.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025621.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025621.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025621.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508014", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508014", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M0L2-1", "protein_name": "Transmembrane protein 102", "gene_name": "Tmem102", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTVWGGAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSEGPEPGADLLRAKEFVFSLLGLVHRQDPRFPPQAELLLLRGGIREGSVDLGHAPLGPYSRGPHYDAGFTVLVPVFSLDGTGPELLLDLESCSAWLRLPELMRGILVREAWLDCLGPPVPEESDMTPQTQGKESPTDRGNSVDQSHDCVPEPEPHMSLQKFSDLSGSQSPYNDIANLEAPEPLETPSSEALETDESPVPRPSEAAKVWPTLCPTQVASWFFVKLAEVAESLIPVPGAPRLVHAARHAGVTTVLLATPEPPRHLLLFDLIPVVTVTGWPDAARSHSWAGPLVSESSSFYLVPGSLPEQQGTSGWQLCFARQELALKARIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELSRVLEAGTLPHYFLSGRKLRMGDGSAALRGALAQLRGDPAQALREAVEEAKSLQGTGRMCLLTKCGKKLVFGNLVLINLAHNKAERY", "length": 528 }, "evidence": [ { "id": "Q1LZD1", "url": "https://omabrowser.org/oma/group/Q1LZD1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LIU7-1", "protein_name": "Transmembrane protein 102", "gene_name": "TMEM102", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASAVWGSAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSDGPKPGPDLLQAKDFVFSLLGLIHRRDPRFPPQAELLLLRGGIREGSLDLGPTPLGPYARGPHYDTGFTLLVPELQLDVGSCYAWVCLPEQVRGASIREAWQDCLGPPVPGEGDSIHPTQSEESLKDPKTSVDQPHGDVTDPEAHESLEKSPSNVSVPESPQQDATDVGFPSPLKKTNGDVTKAADVSPMPQPQPSEAREAWPTLCPAQVASLLPVPGAPRLVHAARHAGYTTILLATPGPPRRLLLFDLIPVVSVAGWPEGARSHSWAGPLATESSSFYLVPGGGGGGGTERPEASGWQLCFARQELALKARIAEPLLQAHAAAQALLRPLVVGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEAGTLPHYFLSGQKLRAGDGAVSLLGALALLRGDPARALRAAVEEAKAARKGGGLAGVGGGAH", "length": 495 }, "evidence": [ { "id": "Q1LZD1", "url": "https://omabrowser.org/oma/group/Q1LZD1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UPR7-1", "protein_name": "Transmembrane protein 102", "gene_name": "Tmem102", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTVWGGAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELRVQESWSEGPKPGADLLRAKDFVFALLGLVHRQDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYSRGPHYDAGFTLLVPVFSLDGTGPELLLDLESCSAWLRLPELMRGILVREAWQDCLGPPVPEESDMTHQTHSKESPTDRENSVDPSHDYVPEPEPHMSLQKSSSDLSESQSSYKDITNPETPEPLETLSSDALDADESQVPKPSEAPKAWPTLCPTQVTSWFFVKLAEVAESLIPVPGAPRLVHAARHAGVTTVLLATPEPPRHLLLFDLIPVVTVTGWPDTARSHSWAGPLVSESASFYLVPGSLPEQPSTSGWQLCFARQELALKERIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELSRVLEAGALPHYFLSGRKLRVGDGSAALRGALAQLRGDPAQALREAVEEAKVARKGGGLAGVGGGTH", "length": 509 }, "evidence": [ { "id": "Q1LZD1", "url": "https://omabrowser.org/oma/group/Q1LZD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N9M5-1", "protein_name": "Transmembrane protein 102", "gene_name": "TMEM102", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASAVWGSAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSDGPKPGADLLRAKDFVFSLLGLVHRRDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYARGPHYDAGFTLLVPMFSLDGTELQLDLESCYAQVCLPEMVCGTPIREMWQDCLGPPVPGARDSIHRTESEESSKDWQSSVDQPHSYVTEHEAPVSLEKSPSDVSASESPQHDVVDLGSTAPLKTMSSDVTKAAVESPVPKPSEAREAWPTLCSAQVAAWFFATLAAVAESLIPVPGAPRLVHAARHAGFTTVLLATPEPPRRLLLFDLIPVVSVAGWPEGARSHSWAGPLASESASFYLVPGGGTERPCASAWQLCFARQELALKARIPAPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAALLGELARLRGDPARALRAAVEEAKVARKGGGLAGVGGGAH", "length": 508 }, "evidence": [ { "id": "Q1LZD1", "url": "https://omabrowser.org/oma/group/Q1LZD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" }, { "name": "regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901028", "evidence": [ { "database": "UniProtKB", "id": "Q1LZD1", "url": "https://www.uniprot.org/uniprotkb/Q1LZD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1LZD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 512, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1LZD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1LZD1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 224, "end_pos": 226 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1LZH0-1", "uniprot_ac": "Q1LZH0", "uniprot_id": "U1SBP_BOVIN", "mass": { "chemical_mass": 29294.0, "monoisotopic_mass": 29294.0 }, "refseq": { "ac": "NP_001069024", "name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" }, "gene_names": [ { "name": "SNRNP35", "type": "recommended", "evidence": [ { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ] }, { "name": "SNRNP35", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" } ] }, { "name": "U1SNRNPBP", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" }, { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ] } ], "protein_names": [ { "name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "type": "recommended", "evidence": [ { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0/entry#names_and_taxonomy" } ] }, { "name": "U1 snRNP-binding protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" }, { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0/entry#names_and_taxonomy" } ] }, { "name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" } ] }, { "name": "U11/U12 snRNP 35 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" }, { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0/entry#names_and_taxonomy" } ] }, { "name": "small nuclear ribonucleoprotein 35kDa (U11/U12)", "type": "synonym", "evidence": [ { "id": "NP_001069024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP35", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0", "locus": { "chromosome": "17", "start_pos": 52138741, "end_pos": 52168904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008060", "url": "https://www.ensembl.org/id/ENSBTAG00000008060" } ] } } ], "crossref": [ { "id": "Q1LZH0", "url": "https://alphafold.ebi.ac.uk/entry/Q1LZH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008060", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008060", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12237", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12237", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512142", "url": "https://www.ncbi.nlm.nih.gov/gene/512142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512142", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512142", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FERSRVM", "url": "https://omabrowser.org/oma/group/FERSRVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1LZH0", "url": "https://www.orthodb.org/?gene=Q1LZH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13952:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13952:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069024", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1LZH0-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYTPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKDERSLLKAYRDADGLVIDQHEIFVDYELERTLKGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNDQFREGKRERRERSRSRERHWDSRMRDHHDRGREKRWQEREPARAWPEGDWERERDFRDDRVKGREKRDRSK", "length": 245, "header": "sp|Q1LZH0-1|U1SBP_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Bos taurus OX=9913 GN=SNRNP35 PE=2 SV=1 CANONICAL=Q1LZH0-1" }, "isoforms": [ { "isoform_ac": "Q1LZH0-1", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0/entry#Q1LZH0-1", "sequence": { "sequence": "MNDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYTPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKDERSLLKAYRDADGLVIDQHEIFVDYELERTLKGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNDQFREGKRERRERSRSRERHWDSRMRDHHDRGREKRWQEREPARAWPEGDWERERDFRDDRVKGREKRDRSK", "length": 245, "header": "sp|Q1LZH0-1|U1SBP_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Bos taurus OX=9913 GN=SNRNP35 PE=2 SV=1 CANONICAL=Q1LZH0-1" }, "locus": { "chromosome": "17", "start_pos": 52158760, "end_pos": 52158026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119482.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119482.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079280.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512142", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512142", "resource": "KEGG Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZZR9-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "SNRNP35", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNDWAPIAKEYDPLKAGSIDGTDEEPHDRAIWRAMLARYVPNKGVTGDPHLTLFVARLNLQTTEEKLKEVFSRYGDIRKIRLVRDLVTGFSKGYAFIEYKEERALLKAHRDANRLVIDQHEVFVDFELERTLKGWIPRRLGGGFGGKKESGQLRFGGRDRPFRKPINLPNVKNDFYGEGSAEKRNWSREGTRDWRTRDREHERSREKRGPERERPWGWGDSERDSKEERSRGRERKDRDRKDRDRDRSRERDAKKQRDDDKHR", "length": 263 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I4X5-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "Snrnp35", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERALLKAYRDADGLVIDQHEIFVDYELERTLRGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNEPHREGKRERRERSRSRDRHWDPRPRERNHDRGLEKRWQEREMARVWPENDREREREFREDRAKGRDKRDRSK", "length": 246 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LN96-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "SNRNP35", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNDWVPIAKEYDPLKAGSIDGTDEDPHDRAIWRAMLARYTPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERSLLKAYRDADGLVIDQHEIFVDYELERTLKGWIPRRLGGGLGGKKESGQLRFGGRDRPFRQPINLPVVKNDQFREGKRERRERSRSRERHWDSRMRDRGHDRGRDKRWQEREPARVWPEGDWERERDFRDDRVKGREKRDRSK", "length": 246 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q16560-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "SNRNP35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVIGDPLLTLFVARLNLQTKEDKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERAVIKAYRDADGLVIDQHEIFVDYELERTLKGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNDLYREGKRERRERSRSRERHWDSRTRDRDHDRGREKRWQEREPTRVWPDNDWERERDFRDDRIKGREKKERGK", "length": 246 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4KMD3-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "snrnp35", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEWSPVAKVYDPLKAGSIDGTDVEPHDAGVWRAMLARYKPNRGVCGDPDLTLFVARLNPQTTEEKLRDVFSKFGDIRRLRLVRDVVTGFSKRYAFIEYKEERSLKRAWRDANKLILDQYELLVDVEQERTLPGWRPRRLGGGQGGQKESGQLRFGGRDRPFRKPINLSTRRPAEPRGRETERERDRRDYRDRRHERTHTEDRTHRHTY", "length": 208 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5U1W5-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "Snrnp35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVTGDPLLTLFVARLNSQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERALLKAYRDADGLVIDQHEIFVDYELERTLRGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNEPHREGKRERRERSRSRDRHWDPRPRERDHDRGREKHWQDRARVWPENDWEREREFRDERAKTRDKRDRSK", "length": 244 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D384-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "Snrnp35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERALMKAYRDADGLVIDQHEIFVDYELERTLRGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNEPHREGKRERRERSRSRDRHWDPRPRERDHDRGREKHWQERARVWPENDWEREREFREERVKSRDKRDRSK", "length": 244 }, "evidence": [ { "id": "Q1LZH0", "url": "https://omabrowser.org/oma/group/Q1LZH0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "pmid": "" }, { "name": "snRNA binding", "id": "GO:0017069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017069", "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "pmid": "" }, { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q1LZH0", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1LZH0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 245, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1LZH0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1LZH0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1LZH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZH0" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 51, "end_pos": 129, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMH3-1", "uniprot_ac": "Q1RMH3", "uniprot_id": "COX14_BOVIN", "mass": { "chemical_mass": 6470.0, "monoisotopic_mass": 6470.0 }, "refseq": { "ac": "NP_001181993", "name": "cytochrome c oxidase assembly protein COX14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" }, "gene_names": [ { "name": "COX14", "type": "recommended", "evidence": [ { "id": "Q1RMH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ] }, { "name": "C12orf62", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] }, { "name": "C5H12orf62", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] }, { "name": "COX14", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly protein COX14", "type": "recommended", "evidence": [ { "id": "Q1RMH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3/entry#names_and_taxonomy" } ] }, { "name": "COX14 cytochrome c oxidase assembly homolog", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] }, { "name": "COX14, cytochrome c oxidase assembly factor", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] }, { "name": "cytochrome c oxidase assembly protein COX14", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] }, { "name": "uncharacterized protein C12orf62 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993" } ] } ], "function": [ { "annotation": "Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.", "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3#function" }, { "database": "UniProtKB", "id": "Q96I36", "url": "https://www.uniprot.org/uniprotkb/Q96I36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COX14", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3", "locus": { "chromosome": "5", "start_pos": 29782033, "end_pos": 29787569, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000808", "url": "https://www.ensembl.org/id/ENSBTAG00000000808" } ] } } ], "crossref": [ { "id": "Q1RMH3", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000808", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000808", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768048", "url": "https://www.ncbi.nlm.nih.gov/gene/768048", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768048", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768048", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYHYFQR", "url": "https://omabrowser.org/oma/group/VYHYFQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMH3", "url": "https://www.orthodb.org/?gene=Q1RMH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36684", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36684", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36684:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36684:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14880", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001181993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMH3-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTAKQLADIGYKTFSTSMMLLTVYGGYLCSVRAYHYFQRRSSRRQAAEEQKTSGAL", "length": 57, "header": "sp|Q1RMH3-1|COX14_BOVIN Isoform 1 of Cytochrome c oxidase assembly protein COX14 OS=Bos taurus OX=9913 GN=COX14 PE=3 SV=1 CANONICAL=Q1RMH3-1" }, "isoforms": [ { "isoform_ac": "Q1RMH3-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3/entry#Q1RMH3-1", "sequence": { "sequence": "MPTAKQLADIGYKTFSTSMMLLTVYGGYLCSVRAYHYFQRRSSRRQAAEEQKTSGAL", "length": 57, "header": "sp|Q1RMH3-1|COX14_BOVIN Isoform 1 of Cytochrome c oxidase assembly protein COX14 OS=Bos taurus OX=9913 GN=COX14 PE=3 SV=1 CANONICAL=Q1RMH3-1" }, "locus": { "chromosome": "5", "start_pos": 29783207, "end_pos": 29783037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138892.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138892.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104560.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768048", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768048", "resource": "KEGG Pathway" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LPV7-1", "protein_name": "Cytochrome c oxidase assembly protein COX14", "gene_name": "LOC100772471", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPTAKQLADIGYKTFSASMMLLTVYGGYLCSVRAYRYFQLRSARRQAAEEQKTSGVL", "length": 57 }, "evidence": [ { "id": "Q1RMH3", "url": "https://omabrowser.org/oma/group/Q1RMH3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1A933-1", "protein_name": "COX14, cytochrome c oxidase assembly factor", "gene_name": "COX14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVSGKQLADFGYKAFSGSMMLLTVYGGYLCGVRAYRLLQNRRARQASAGPES", "length": 52 }, "evidence": [ { "id": "Q1RMH3", "url": "https://omabrowser.org/oma/group/Q1RMH3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BH51-1", "protein_name": "Cytochrome c oxidase assembly protein COX14", "gene_name": "Cox14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSAKQLADIGYKTFSASMMLLTVYGGYLCSVRAYRYLQLRSARRQAAEEQKTSGVL", "length": 57 }, "evidence": [ { "id": "Q1RMH3", "url": "https://omabrowser.org/oma/group/Q1RMH3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96I36-1", "protein_name": "Cytochrome c oxidase assembly protein COX14", "gene_name": "COX14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM", "length": 57 }, "evidence": [ { "id": "Q1RMH3", "url": "https://omabrowser.org/oma/group/Q1RMH3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q1RMH3", "url": "https://www.uniprot.org/uniprotkb/Q1RMH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 57, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMH3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RML4-1", "uniprot_ac": "Q1RML4", "uniprot_id": "SPIC_BOVIN", "mass": { "chemical_mass": 29112.0, "monoisotopic_mass": 29112.0 }, "refseq": { "ac": "NP_001069889", "name": "transcription factor Spi-C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069889" }, "gene_names": [ { "name": "SPIC", "type": "recommended", "evidence": [ { "id": "Q1RML4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ] }, { "name": "SPIC", "type": "synonym", "evidence": [ { "id": "NP_001069889", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069889" } ] } ], "protein_names": [ { "name": "Transcription factor Spi-C", "type": "recommended", "evidence": [ { "id": "Q1RML4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML4/entry#names_and_taxonomy" } ] }, { "name": "Spi-C transcription factor (Spi-1/PU.1 related)", "type": "synonym", "evidence": [ { "id": "NP_001069889", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069889" } ] }, { "name": "transcription factor Spi-C", "type": "synonym", "evidence": [ { "id": "NP_001069889", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069889" } ] } ], "function": [ { "annotation": "Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPIC", "url": "https://www.uniprot.org/uniprotkb/Q1RML4", "locus": { "chromosome": "5", "start_pos": 65337376, "end_pos": 65323557, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009904", "url": "https://www.ensembl.org/id/ENSBTAG00000009904" } ] } } ], "crossref": [ { "id": "Q1RML4", "url": "https://alphafold.ebi.ac.uk/entry/Q1RML4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009904", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009904", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616438", "url": "https://www.ncbi.nlm.nih.gov/gene/616438", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616438", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616438", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YSWRNVI", "url": "https://omabrowser.org/oma/group/YSWRNVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RML4", "url": "https://www.orthodb.org/?gene=Q1RML4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069889", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RML4-1", "url": "https://www.uniprot.org/uniprotkb/Q1RML4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACAEQDKLGQAFEDAFEVLRQHSTGDFQYSSDYKNYLAFINHRSHIRGNSNSYGVQPAEEPIYNWRTVINSATDLYFEGNIHQSLQNIPENQLVQPALLQQKGGKGRKKLRLFEYLHESLCNPEMASCIQWIDQTKGIFQFVSKNKEKLAQLWGKRKGNRKTMTYQKMARALRNYGRTGEIIKIRRKLTYQFSEAILQRLSAPYFLEKEIFYSQYVQPDQGYLSLNNWNANYNYTYANYHELSHPDC", "length": 248, "header": "sp|Q1RML4-1|SPIC_BOVIN Isoform 1 of Transcription factor Spi-C OS=Bos taurus OX=9913 GN=SPIC PE=2 SV=1 CANONICAL=Q1RML4-1" }, "isoforms": [ { "isoform_ac": "Q1RML4-1", "url": "https://www.uniprot.org/uniprotkb/Q1RML4/entry#Q1RML4-1", "sequence": { "sequence": "MACAEQDKLGQAFEDAFEVLRQHSTGDFQYSSDYKNYLAFINHRSHIRGNSNSYGVQPAEEPIYNWRTVINSATDLYFEGNIHQSLQNIPENQLVQPALLQQKGGKGRKKLRLFEYLHESLCNPEMASCIQWIDQTKGIFQFVSKNKEKLAQLWGKRKGNRKTMTYQKMARALRNYGRTGEIIKIRRKLTYQFSEAILQRLSAPYFLEKEIFYSQYVQPDQGYLSLNNWNANYNYTYANYHELSHPDC", "length": 248, "header": "sp|Q1RML4-1|SPIC_BOVIN Isoform 1 of Transcription factor Spi-C OS=Bos taurus OX=9913 GN=SPIC PE=2 SV=1 CANONICAL=Q1RML4-1" }, "locus": { "chromosome": "5", "start_pos": 65336372, "end_pos": 65325735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070386.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070386.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068421.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068421.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616438", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616438", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A5W3-1", "protein_name": "Transcription factor Spi-C", "gene_name": "Spic", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTCVELFPQTFVQQDSLGQAFEDAFEVLTQHSTGEMQYPPEHRNYMAIINPYPHIRGNSNYCGMLPPTEEPLYDWRGVTNGSADLYLEGSFHQSLQNVAETQLVQAPFFQEKGGRGRRKLRLFEYLFESLCNSEMVSCIQWVDKAKGIFQFISKNKEKLAELWGKRKGNRKPMTYQKMARALRNYARTGEITKIRRKLTYQFSEAVLQRLAPSHFLGKDLFYSQYKQPDQGYLNLNHWNANYYAHASYQS", "length": 250 }, "evidence": [ { "id": "Q1RML4", "url": "https://omabrowser.org/oma/group/Q1RML4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SRI6-1", "protein_name": "Transcription factor Spi-C", "gene_name": "SPIC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACVEQDKLGQAFEDAFEVLRQHSTGDLQYSSDYKNYLAFINHCSHVRGNSNSYGVLPTEEPVYNWRTVINGAADLYFEGNIHQSLQNIPENQLVQPAVLQQKGGKGRKKLRLFEYLHESLCNPEMASCIQWIDQTKGIFQFVSKNKEKLAQLWGKRKGNRKTMTYQKMARALRNYGRTGEIIKIRRKLTYQFSEAILQRLSPSYFLEKEFFYSQYVQPDQGYLSLNNWNANYNCAYANYHELSHADC", "length": 248 }, "evidence": [ { "id": "Q1RML4", "url": "https://omabrowser.org/oma/group/Q1RML4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6P3D7-1", "protein_name": "Transcription factor Spi-C", "gene_name": "Spic", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTCCIDQDSLGQTFQDAIDILIQQSAGESQYSSENRNYMAIINPYPHVRGNANYYGMSPTENPLYDWRGVTNGSADLYLEGGFHQSVQNIAESQLVQPPFFQQKGGRGRRKLRLFEYLFESLCNSEMVSCIQWVDKARGIFQFISKNKETLAELWGQRKGNRKPMTYQKMARALRNYARTGEIIKIRRKLTYQFSEAVLQRLAPANYLGKDLFYPQYGQPDQGYLSLNHWNANHYAHGSYQS", "length": 242 }, "evidence": [ { "id": "Q1RML4", "url": "https://omabrowser.org/oma/group/Q1RML4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N5J4-1", "protein_name": "Transcription factor Spi-C", "gene_name": "SPIC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHRPHVKGNSSCYGVLPTEEPVYNWRTVINSAADFYFEGNIHQSLQNITENQLVQPTLLQQKGGKGRKKLRLFEYLHESLYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALRNYGRSGEITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNWNANYNYTYANYHELNHHDC", "length": 248 }, "evidence": [ { "id": "Q1RML4", "url": "https://omabrowser.org/oma/group/Q1RML4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q1RML4", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RML4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 248, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RML4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RML4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1RML4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML4" }, { "id": "PRU00237", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00237" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000255", "start_pos": 111, "end_pos": 194, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RML7-1", "uniprot_ac": "Q1RML7", "uniprot_id": "MAK16_BOVIN", "mass": { "chemical_mass": 35289.0, "monoisotopic_mass": 35289.0 }, "refseq": { "ac": "NP_001068638", "name": "protein MAK16 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638" }, "gene_names": [ { "name": "MAK16", "type": "recommended", "evidence": [ { "id": "Q1RML7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ] }, { "name": "MAK16", "type": "synonym", "evidence": [ { "id": "NP_001068638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638" } ] }, { "name": "RBM13", "type": "synonym", "evidence": [ { "id": "NP_001068638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638" } ] } ], "protein_names": [ { "name": "Protein MAK16 homolog", "type": "recommended", "evidence": [ { "id": "Q1RML7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML7/entry#names_and_taxonomy" } ] }, { "name": "RNA binding motif protein 13", "type": "synonym", "evidence": [ { "id": "NP_001068638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638" } ] }, { "name": "protein MAK16 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAK16", "url": "https://www.uniprot.org/uniprotkb/Q1RML7", "locus": { "chromosome": "27", "start_pos": 29214791, "end_pos": 29204700, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033504", "url": "https://www.ensembl.org/id/ENSBTAG00000033504" } ] } } ], "crossref": [ { "id": "Q1RML7", "url": "https://alphafold.ebi.ac.uk/entry/Q1RML7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033504", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033504", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504683", "url": "https://www.ncbi.nlm.nih.gov/gene/504683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504683", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504683", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DKGQNFC", "url": "https://omabrowser.org/oma/group/DKGQNFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RML7", "url": "https://www.orthodb.org/?gene=Q1RML7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068638", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RML7-1", "url": "https://www.uniprot.org/uniprotkb/Q1RML7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLHKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDAEEKDDEEDEEDVGKREFVEDDEVDESDISDFEDMDKLDASSDEDQDDKSSSEEEEKTLDAKHKGKTPLKGPLRRKRAYVEIEYEQETEPAAKAKTT", "length": 298, "header": "sp|Q1RML7-1|MAK16_BOVIN Isoform 1 of Protein MAK16 homolog OS=Bos taurus OX=9913 GN=MAK16 PE=2 SV=1 CANONICAL=Q1RML7-1" }, "isoforms": [ { "isoform_ac": "Q1RML7-1", "url": "https://www.uniprot.org/uniprotkb/Q1RML7/entry#Q1RML7-1", "sequence": { "sequence": "MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLHKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDAEEKDDEEDEEDVGKREFVEDDEVDESDISDFEDMDKLDASSDEDQDDKSSSEEEEKTLDAKHKGKTPLKGPLRRKRAYVEIEYEQETEPAAKAKTT", "length": 298, "header": "sp|Q1RML7-1|MAK16_BOVIN Isoform 1 of Protein MAK16 homolog OS=Bos taurus OX=9913 GN=MAK16 PE=2 SV=1 CANONICAL=Q1RML7-1" }, "locus": { "chromosome": "27", "start_pos": 29213718, "end_pos": 29204778, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047639.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047639.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044825.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "site_lbl": "Ser197" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "site_lbl": "Ser200" }, { "start_pos": 228, "end_pos": 228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "site_lbl": "Ser228" }, { "start_pos": 231, "end_pos": 231, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "site_lbl": "Ser231" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504683", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504683", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AVJ1-1", "protein_name": "Protein MAK16 homolog", "gene_name": "MAK16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLHKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAGSDSSDAEEKDEEDEEDVGKREFVEDDEVDESDISDFEDMDKLDASSDEEQDDKSSTEEEEKALDAKYKGKTPLKGPLRRKRAYVEIEYEQETEPMAKAKTT", "length": 297 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A0Z5-1", "protein_name": "Protein MAK16 homolog", "gene_name": "Mak16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "NQNDSPTSLIVIWNTLGNKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRRKKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEKQEAESDSEDEEDEEEDEEEDVGKREFVEDDEVEESDLSDFEDMDKLNTDSEEDDESSREEEAHKAKHKGKAPLKGPLRKKRAYVEIEYEQETEPMAKAKAT", "length": 298 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4I4Q1-1", "protein_name": "Protein MAK16 homolog", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MQHDEVIWQVIRHKHCSYMAKIETGIFCRNQYNVTGICNRSSCPLANSRYATIRDHDGVFYLYMKTIERAHMPNKLWERVKLPVNYEKALEMIDKHLLYWPKLLQHKVKQRLTKMTQMRIRMRKLALKTREVVVTTPRRQIKRESRREEKAIKAAQLDKAIETELMERLKKGIYPTEIYNLSDSVFNKLLDREIETNDEVEKEEEEEGVIEYVEGDDELEAEEEEDMEDFSGLPSKESYLEGDDHDSDDEDDDDAEEQVVIHKKGRALKKSDDNGKAKKKPRVVVEVEQEDADTRRSLKSLKI", "length": 303 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P10962-1", "protein_name": "Protein MAK16", "gene_name": "MAK16", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDEIVWQVINQSFCSHRIKAPNGQNFCRNEYNVTGLCTRQSCPLANSKYATVKCDNGKLYLYMKTPERAHTPAKLWERIKLSKNYTKALQQIDEHLLHWSKFFRHKCKQRFTKLTQVMITERRLALREEERHYVGVAPKVKRREQNRERKALVAAKIEKAIEKELMDRLKSGAYGDKPLNVDEKVWKKIMGQMEEENSQDEEEDWDEEEESDDGEVEYVADDGEGEYVDVDDLEKWLADSDREASSASESESDSESESDSDSDEENKNSAKRRKKGTSAKTKRPKVEIEYEEEHEVQNAEQEVAQ", "length": 306 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55DJ3-1", "protein_name": "Protein MAK16 homolog", "gene_name": "mak16l", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQSDDIIWDVINKNFCSFKTTFNKTKFCKNEYNVTGVCNKVSCPLANSRYATVREEEGVCYLYMKTVERAHTPNRLWEKIKLDPNFMKAIEQIDSHLEFWPGHMSHRVKQRYIRITQYLIRMRKMRKQIKRELVPIKKKAERRDATRENKALIAAHLTTNIKKELLERLNKGTYADMHYFPEDIINNVLEKEGEADQFSEEEADENEEEGEEEMEEEFEDDIDDIEDAGGAFEYVEGDDDEDDIDDEYENEPYQDDDEEDDDDDDDDDEEVKPQITKKRGPTFKPTKKTPQKRVHMEVEIEEETENQAN", "length": 309 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6NYD4-1", "protein_name": "Protein MAK16 homolog", "gene_name": "mak16", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQHDDVIWDLIGNKSFCSYKVKTKTQQFCRNEYNITGLCNRSSCPLANSQYATIREEKGQCFLYMKVIERAAFPSRMWEKVKLDRNYAKALEQIDENLIYWPRFIRHKCKQRLTKITQYLIRIRKLTLKRQRKLVPLSRKVERREKRREEKALIAAQLENAIEKELLDRLKQGTYGDIYNFPINAFDKAMEKQDEESESEEEEEEEDEEESGTREFIAEDEFEESDLSDFEELNNLKDSSDEEVNDEEESSEESEEESEEEEVKSKAKSKGKAPLKGPSRKKRAYVEIEYEQETEPAQKSKAT", "length": 303 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BGS0-1", "protein_name": "Protein MAK16 homolog", "gene_name": "Mak16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSDDVIWNTLGNKQFCSFKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEKQEAESDSEDEEEEEDEDEEEDVGKREFVEDEEVEESDLSDFEDMDKLNTDSEEDQDDESSNDEEAHKAKHKGKAPLKGPLRKKRAYVEIEYEQETEPMAKVKAT", "length": 296 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BXY0-1", "protein_name": "Protein MAK16 homolog", "gene_name": "MAK16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDTEEKDDDDDDEEDVGKREFVEDGEVDESDISDFEDMDKLDASSDEDQDGKSSSEEEEEKALSAKHKGKMPLRGPLQRKRAYVEIEYEQETEPVAKAKTT", "length": 300 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W3B2-1", "protein_name": "Protein MAK16 homolog", "gene_name": "Rbm13", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQHDDVVWSIINKSFCSHKVKTDTRTFCRHEYNLTGLCTRRTCPLANSQYATVREEKGIIYLFIKTAERAHMPSKLWERIKLSRNFEKAIEQINENLVFWPKYMIAKNKQRFLKITQYLIRMRRLKLRRQKLIVPLSTKIERREARREEKALVAAKIDNHIEKALMDRLKNGTYRDIYNFSQTAFNKALEAERVDEDDEEELDDEDENEEQLEREMEVDGDDSREAEEVQRSLLDEEFVEADTDDEEEDDDDDDDDDEDDYDSDSGKREEVEVGSDFEESDEDDDADADDIEETKVPAKKTASKAKKDKKSPAGNSRRSRSKPKLQLEYEYEVEKEAQRQMRH", "length": 343 }, "evidence": [ { "id": "Q1RML7", "url": "https://omabrowser.org/oma/group/Q1RML7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "pmid": "" }, { "name": "preribosome, large subunit precursor", "id": "GO:0030687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "maturation of 5.8S rRNA", "id": "GO:0000460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000460", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "Q1RML7", "url": "https://www.uniprot.org/uniprotkb/Q1RML7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RML7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 298, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RML7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RML7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 197, 200, 228, 231 ], "sequon_annotation_sites": [ { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMM0-1", "uniprot_ac": "Q1RMM0", "uniprot_id": "THAP5_BOVIN", "mass": { "chemical_mass": 45282.0, "monoisotopic_mass": 45282.0 }, "refseq": { "ac": "NP_001069807", "name": "THAP domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069807" }, "gene_names": [ { "name": "THAP5", "type": "recommended", "evidence": [ { "id": "Q1RMM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ] }, { "name": "THAP5", "type": "synonym", "evidence": [ { "id": "NP_001069807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069807" } ] } ], "protein_names": [ { "name": "THAP domain-containing protein 5", "type": "recommended", "evidence": [ { "id": "Q1RMM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0/entry#names_and_taxonomy" } ] }, { "name": "THAP domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001069807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069807" } ] } ], "function": [ { "annotation": "Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0#function" }, { "database": "UniProtKB", "id": "Q7Z6K1", "url": "https://www.uniprot.org/uniprotkb/Q7Z6K1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THAP5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0", "locus": { "chromosome": "4", "start_pos": 59594296, "end_pos": 59588215, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021869", "url": "https://www.ensembl.org/id/ENSBTAG00000021869" } ] } } ], "crossref": [ { "id": "Q1RMM0", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "614615", "url": "https://www.ncbi.nlm.nih.gov/gene/614615", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614615", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614615", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1RMM0", "url": "https://www.orthodb.org/?gene=Q1RMM0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46927", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46927", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46927:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46927:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069807", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMM0-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRYCAAICCKNRRGRNNKERKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFALPEDNQEKDPSKKKSQKKKLKSEKEVCLKAKSEESFASNEPKKHPVNTDLLPEHAELLESSALVKPPDPKAESVQNNILTLSLVKQGTRKPESILETSVNQDMGIGGFHTSFENLSSTTITLTTASSEGIQQPLETQEVIEITTNHLANPHFTNNSVEIKSAQENPFILSTVTQTVEELNTDKESVIAIFVPTENSKPAINSFIPAPKTVEMEEDIDIEDSYKDVDYETEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 394, "header": "sp|Q1RMM0-1|THAP5_BOVIN Isoform 1 of THAP domain-containing protein 5 OS=Bos taurus OX=9913 GN=THAP5 PE=2 SV=2 CANONICAL=Q1RMM0-1" }, "isoforms": [ { "isoform_ac": "Q1RMM0-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0/entry#Q1RMM0-1", "sequence": { "sequence": "MPRYCAAICCKNRRGRNNKERKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFALPEDNQEKDPSKKKSQKKKLKSEKEVCLKAKSEESFASNEPKKHPVNTDLLPEHAELLESSALVKPPDPKAESVQNNILTLSLVKQGTRKPESILETSVNQDMGIGGFHTSFENLSSTTITLTTASSEGIQQPLETQEVIEITTNHLANPHFTNNSVEIKSAQENPFILSTVTQTVEELNTDKESVIAIFVPTENSKPAINSFIPAPKTVEMEEDIDIEDSYKDVDYETEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 394, "header": "sp|Q1RMM0-1|THAP5_BOVIN Isoform 1 of THAP domain-containing protein 5 OS=Bos taurus OX=9913 GN=THAP5 PE=2 SV=2 CANONICAL=Q1RMM0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614615", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614615", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "pmid": "" }, { "name": "negative regulation of cell cycle", "id": "GO:0045786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM0", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMM0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMM0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMM0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1RMM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM0" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "HCFC1-binding motif (HBM)", "eco_id": "ECO_0000250", "start_pos": 320, "end_pos": 323, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 239, "end_pos": 241 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMM5-1", "uniprot_ac": "Q1RMM5", "uniprot_id": "NP1L5_BOVIN", "mass": { "chemical_mass": 20399.0, "monoisotopic_mass": 20399.0 }, "refseq": { "ac": "NP_001071346", "name": "nucleosome assembly protein 1-like 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" }, "gene_names": [ { "name": "NAP1L5", "type": "recommended", "evidence": [ { "id": "Q1RMM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5" } ] }, { "name": "NAP1L5", "type": "synonym", "evidence": [ { "id": "NP_001071346", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" } ] } ], "protein_names": [ { "name": "Nucleosome assembly protein 1-like 5", "type": "recommended", "evidence": [ { "id": "Q1RMM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5/entry#names_and_taxonomy" } ] }, { "name": "Histone chaperone NAP1L5", "type": "synonym", "evidence": [ { "id": "Q1RMM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5/entry#names_and_taxonomy" } ] }, { "name": "histone chaperone NAP1L5", "type": "synonym", "evidence": [ { "id": "NP_001071346", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" } ] }, { "name": "nucleosome assembly protein 1-like 5", "type": "synonym", "evidence": [ { "id": "NP_001071346", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" } ] } ], "function": [ { "annotation": "This is the first report on the imprinting status of NAP1L5. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001071346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" }, { "database": "PubMed", "id": "17064418", "url": "https://glygen.org/publication/PubMed/17064418" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMM5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAP1L5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5", "locus": { "chromosome": "6", "start_pos": 36084996, "end_pos": 36082066, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010128", "url": "https://www.ensembl.org/id/ENSBTAG00000010128" } ] } } ], "crossref": [ { "id": "Q1RMM5", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010128", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010128", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508508", "url": "https://www.ncbi.nlm.nih.gov/gene/508508", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508508", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508508", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ATKPKND", "url": "https://omabrowser.org/oma/group/ATKPKND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMM5", "url": "https://www.orthodb.org/?gene=Q1RMM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMM5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMM5-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSQNQGSAEPSQAAAAAAAADAAAAAEEVMAEGGAQGGDSDSASSDSDGVVGQMAEEPQTPAENAPKPRNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGDEEDDDDDEYEDEEEGEEEDEEEEEPAAEAAGTAAAKDEGPHSAVPDDAKK", "length": 192, "header": "sp|Q1RMM5-1|NP1L5_BOVIN Isoform 1 of Nucleosome assembly protein 1-like 5 OS=Bos taurus OX=9913 GN=NAP1L5 PE=2 SV=1 CANONICAL=Q1RMM5-1" }, "isoforms": [ { "isoform_ac": "Q1RMM5-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5/entry#Q1RMM5-1", "sequence": { "sequence": "MADSQNQGSAEPSQAAAAAAAADAAAAAEEVMAEGGAQGGDSDSASSDSDGVVGQMAEEPQTPAENAPKPRNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGDEEDDDDDEYEDEEEGEEEDEEEEEPAAEAAGTAAAKDEGPHSAVPDDAKK", "length": 192, "header": "sp|Q1RMM5-1|NP1L5_BOVIN Isoform 1 of Nucleosome assembly protein 1-like 5 OS=Bos taurus OX=9913 GN=NAP1L5 PE=2 SV=1 CANONICAL=Q1RMM5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Assessment of genomic imprinting of SLC38A4, NNAT, NAP1L5, and H19 in cattle.", "journal": "BMC genetics", "date": "2006-10-25", "authors": "Zaitoun Ismail, Khatib Hasan", "evidence": [ { "database": "RefSeq", "id": "NP_001071346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071346" } ], "reference": [ { "type": "PubMed", "id": "17064418", "url": "https://glygen.org/publication/PubMed/17064418" } ] } ], "pathway": [ { "id": "bta:508508", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508508", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LPA8-1", "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "Nap1l5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADPEKQGPAESRAEDEVMEGAQGGEDVATGGEGAAAPAAEEPQATGENAPKPKNEFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEEDDDDDEEEDEEEEEEEEEAAAGATGGPDSAKK", "length": 156 }, "evidence": [ { "id": "Q1RMM5", "url": "https://omabrowser.org/oma/group/Q1RMM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5PPG6-1", "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "Nap1l5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADPEKQGPAESRAEDEVMEGAQGGEDAATGDSATAPAAEEPQAPAENAPKPKNDFIESLPNPVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGEDDEDDEEEEDEEEEEEEAAAGATGGPDSAEK", "length": 155 }, "evidence": [ { "id": "Q1RMM5", "url": "https://omabrowser.org/oma/group/Q1RMM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96NT1-1", "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "NAP1L5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSENQGPAEPSQAAAAAEAAAEEVMAEGGAQGGDCDSAAGDPDSAAGQMAEEPQTPAENAPKPKNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGEEEEEEEYEDDEEEGEDEEEEEAAAEAAAGAKHDDAHAEMPDDAKK", "length": 182 }, "evidence": [ { "id": "Q1RMM5", "url": "https://omabrowser.org/oma/group/Q1RMM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJF0-1", "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "Nap1l5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADPEKQGPAESRAEDEVMEGAQGGEDAATGDSAAAPAAEEPQAPAENAPKPKKDFMESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGEDDEDDEEEDDEEEEEEEEAAAGATGGPNFAKK", "length": 156 }, "evidence": [ { "id": "Q1RMM5", "url": "https://omabrowser.org/oma/group/Q1RMM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "Q1RMM5", "url": "https://www.uniprot.org/uniprotkb/Q1RMM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 192, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMM5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q1RMP7-1", "uniprot_ac": "Q1RMP7", "uniprot_id": "PPIL6_BOVIN", "mass": { "chemical_mass": 34679.0, "monoisotopic_mass": 34679.0 }, "refseq": { "ac": "NP_001040002", "name": "probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" }, "gene_names": [ { "name": "PPIL6", "type": "recommended", "evidence": [ { "id": "Q1RMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7" } ] }, { "name": "PPIL6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] } ], "protein_names": [ { "name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "type": "recommended", "evidence": [ { "id": "Q1RMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7/entry#names_and_taxonomy" } ] }, { "name": "Cyclophilin-like protein PPIL6", "type": "synonym", "evidence": [ { "id": "Q1RMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7/entry#names_and_taxonomy" } ] }, { "name": "PPIase", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" }, { "id": "Q1RMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7/entry#names_and_taxonomy" } ] }, { "name": "cyclophilin-like protein PPIL6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] }, { "name": "peptidyl-prolyl cis-trans isomerase-like 6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] }, { "name": "peptidylprolyl isomerase (cyclophilin)-like 6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] }, { "name": "probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] }, { "name": "problable inactive peptidyl-prolyl cis-trans isomerase-like 6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] }, { "name": "rotamase PPIL6", "type": "synonym", "evidence": [ { "id": "NP_001040002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002" } ] } ], "function": [ { "annotation": "Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q1RMP7", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7#function" }, { "database": "UniProtKB", "id": "Q8IXY8", "url": "https://www.uniprot.org/uniprotkb/Q8IXY8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMP7", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPIL6", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7", "locus": { "chromosome": "9", "start_pos": 40749877, "end_pos": 40714260, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008144", "url": "https://www.ensembl.org/id/ENSBTAG00000008144" } ] } } ], "crossref": [ { "id": "Q1RMP7", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008144", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008144", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614498", "url": "https://www.ncbi.nlm.nih.gov/gene/614498", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614498", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614498", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECKIINC", "url": "https://omabrowser.org/oma/group/ECKIINC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMP7", "url": "https://www.orthodb.org/?gene=Q1RMP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11071:SF561", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11071:SF561", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMP7", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMP7-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQQHSVPCISRSPPEQPLQVKVVGLFKSSSFQIAKSAAESLKSNYPSNFEDPIIIPVQEFAWHQYLQEKKRELKNEVWEYSSYVMCFINDKLLGDALDLQKWAHKVWDIVDFKPPALYEALTVDYSAKFLRDTKHNFVFLDISIDLYPIGRLIFELYSDTCPKTCKNFQILCTGKAGFSQSGIKLHYTGSIFHRVVRNGWVQGGDIVAGKGDNGESIYGPTFEDENFSVPHNKRGVLGMVNKGRHSNGSQFYITLQAAPYLDKKYVAFGQLIEGTDVLHHLESVPTENERPIQNCVITASGQLYA", "length": 307, "header": "sp|Q1RMP7-1|PPIL6_BOVIN Isoform 1 of Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 OS=Bos taurus OX=9913 GN=PPIL6 PE=1 SV=1 CANONICAL=Q1RMP7-1" }, "isoforms": [ { "isoform_ac": "Q1RMP7-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7/entry#Q1RMP7-1", "sequence": { "sequence": "MASQQHSVPCISRSPPEQPLQVKVVGLFKSSSFQIAKSAAESLKSNYPSNFEDPIIIPVQEFAWHQYLQEKKRELKNEVWEYSSYVMCFINDKLLGDALDLQKWAHKVWDIVDFKPPALYEALTVDYSAKFLRDTKHNFVFLDISIDLYPIGRLIFELYSDTCPKTCKNFQILCTGKAGFSQSGIKLHYTGSIFHRVVRNGWVQGGDIVAGKGDNGESIYGPTFEDENFSVPHNKRGVLGMVNKGRHSNGSQFYITLQAAPYLDKKYVAFGQLIEGTDVLHHLESVPTENERPIQNCVITASGQLYA", "length": 307, "header": "sp|Q1RMP7-1|PPIL6_BOVIN Isoform 1 of Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 OS=Bos taurus OX=9913 GN=PPIL6 PE=1 SV=1 CANONICAL=Q1RMP7-1" }, "locus": { "chromosome": "9", "start_pos": 40749798, "end_pos": 40714268, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010705.4", "url": "https://www.ensembl.org/id/ENSBTAT00000010705.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010705.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010705.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614498", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614498", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MQA1-1", "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "gene_name": "Ppil6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTASPQQCRPKASACRTLVQPEPLLQVKVVGLFKSSSFQVSKTIAETLKNSYPSRFEDPVIIPLQEFDWDQYLQEKKRELRGETWVYSSYVMCFVNDQLLGNAFDLKKWAQKVWDVVDVRPSALYEALTLDYATKFLKDTKHDFVYLDICIDLSPIGRLIFELYCDTCPKTCKNFQVLCTGTAGFSERGIKLHYKDSIFHRVVQNGWIQGGDIVEGRGDDGESIYGPTFEDENFSVPHNKRGILGMVNKGRHTNASQFYITLQSAPYLDKKYVAFGQLIEGTEVLRQLELVPTENERPMLLCSITDSGILYA", "length": 312 }, "evidence": [ { "id": "Q1RMP7", "url": "https://omabrowser.org/oma/group/Q1RMP7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8W4FDC7-1", "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "gene_name": "PPIL6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASQRLSVPCSSQLPPEQPLQVKVVGLFKSSSFQVAKSTAESLKRNYPSKFEDPIIVPVQEFAWDQYLQEKKRELKNEIWEYSSYVMCFINDQLLGDALDLQKWAHKVWDIVDFKPPALYEALTLDYSTKFLRDTKHDFVFLDISIDLYPVGRLIFELYCDTCPKTCKNFQVLCTGKAGFSQSGIRLHYAGSIFHRVVRNGWVQGGDIVAGKGDNGESIYGPTFEDENFSIPHNKRGVLGMVNKGHHSNGSQFYITLQPTPYLDRKYVAFGQLIEGTDVLQQLELVPTENERPIQKCVILNSGDLYA", "length": 307 }, "evidence": [ { "id": "Q1RMP7", "url": "https://omabrowser.org/oma/group/Q1RMP7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8IXY8-1", "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "gene_name": "PPIL6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDPILVPLQEFAWHQYLQEKKRELKNETWEYSSSVISFVNGQFLGDALDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKHDFVFLDICIDSSPIGRLIFELYCDVCPKTCKNFQVLCTGKAGFSQRGIRLHYKNSIFHRIVQNGWIQGGDIVYGKGDNGESIYGPTFEDENFSVPHNKRGVLGMANKGRHSNGSQFYITLQATPYLDRKFVAFGQLIEGTEVLKQLELVPTQNERPIHMCRITDSGDPYA", "length": 311 }, "evidence": [ { "id": "Q1RMP7", "url": "https://omabrowser.org/oma/group/Q1RMP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6D8-1", "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "gene_name": "Ppil6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATQQPCRPKSKPPACHVRLPPEPPLKLKVVGLFKSSSFQVSKTIAETLKTSYPYRFEDPVIVPLQEFAWDQFLEEKKRELKGETWVYSSYVMCFVNDQLLGNAFDLKKWAQKVWDVIDVRPSALYEALTLDYATKFLKDTKHDFVYLDICIDLSPIGRLIFELYCDACPRTCTNFQVLCTGTSGFSERGTKLHYKDSIFHRVVQNGWIQGGDIVQGRGDDGESIYGPTFEDENFSIPHNKRGVLGMVNKGHHTNGSQFYITLQAAPYLDKKYVAFGQLIEGTHVLKQLELVPTENERPLLLCSIADSGVLYT", "length": 313 }, "evidence": [ { "id": "Q1RMP7", "url": "https://omabrowser.org/oma/group/Q1RMP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1RMP7", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q1RMP7", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMP7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1RMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMP7" }, { "id": "PRU00156", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase cyclophilin-type", "eco_id": "ECO_0000255", "start_pos": 141, "end_pos": 304, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 }, { "start_pos": 249, "end_pos": 251 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMQ3-1", "uniprot_ac": "Q1RMQ3", "uniprot_id": "SYS1_BOVIN", "mass": { "chemical_mass": 17445.0, "monoisotopic_mass": 17445.0 }, "refseq": { "ac": "NP_001039992", "name": "protein SYS1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992" }, "gene_names": [ { "name": "SYS1", "type": "recommended", "evidence": [ { "id": "Q1RMQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ] }, { "name": "SYS1", "type": "synonym", "evidence": [ { "id": "NP_001039992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992" } ] } ], "protein_names": [ { "name": "Protein SYS1 homolog", "type": "recommended", "evidence": [ { "id": "Q1RMQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3/entry#names_and_taxonomy" } ] }, { "name": "SYS1 Golgi-localized integral membrane protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001039992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992" } ] }, { "name": "dysbindin (dystrobrevin binding protein 1) domain containing 2", "type": "synonym", "evidence": [ { "id": "NP_001039992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992" } ] }, { "name": "protein SYS1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992" } ] } ], "function": [ { "annotation": "Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYS1", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3", "locus": { "chromosome": "13", "start_pos": 73711211, "end_pos": 73707706, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005181", "url": "https://www.ensembl.org/id/ENSBTAG00000005181" } ] } } ], "crossref": [ { "id": "Q1RMQ3", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005181", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005181", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614236", "url": "https://www.ncbi.nlm.nih.gov/gene/614236", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016973", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016973", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614236", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614236", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EYEMVGM", "url": "https://omabrowser.org/oma/group/EYEMVGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMQ3", "url": "https://www.orthodb.org/?gene=Q1RMQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12952:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12952:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09801", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09801", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVHSSPSLDQVFDAEILGFSTPPGRLSTMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRSELKEIPLNSAPKSSV", "length": 156, "header": "sp|Q1RMQ3-1|SYS1_BOVIN Isoform 1 of Protein SYS1 homolog OS=Bos taurus OX=9913 GN=SYS1 PE=2 SV=1 CANONICAL=Q1RMQ3-1" }, "isoforms": [ { "isoform_ac": "Q1RMQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3/entry#Q1RMQ3-1", "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVHSSPSLDQVFDAEILGFSTPPGRLSTMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRSELKEIPLNSAPKSSV", "length": 156, "header": "sp|Q1RMQ3-1|SYS1_BOVIN Isoform 1 of Protein SYS1 homolog OS=Bos taurus OX=9913 GN=SYS1 PE=2 SV=1 CANONICAL=Q1RMQ3-1" }, "locus": { "chromosome": "13", "start_pos": 73710886, "end_pos": 73707800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006825.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006825.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006825.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006825.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614236", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614236", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZY25-1", "protein_name": "Protein SYS1 homolog", "gene_name": "Sys1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDALVRSSPSLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLSSAPKSNV", "length": 156 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FBT7-1", "protein_name": "Protein SYS1 homolog", "gene_name": "sys1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASHFRSYVWDPVLIISQIVLMQCIYYSFLGLWLAGVDGLVQTSRSLDQIFSYEVLGFSTTHGRLSMMAFILNSLTCAFGLWFFIRRGKQCLDFTVTVHFFHMIGCWIYNAHLPAALSWWLVNVACMALMAVIGEYLCMRTELRAIPVNTAPKSNL", "length": 156 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SD37-1", "protein_name": "Protein SYS1 homolog", "gene_name": "SYS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSTMSFVLNAPTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRSELKEIPLNSAPKSNV", "length": 156 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P41544-1", "protein_name": "Protein SYS1", "gene_name": "SYS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVSIRRYLRVPNELKPSQIFKQDSLSPSKIGLQIVLLQIFYYTTAIVLFYCWAKLAGYDLNIKEWLFSWENIDFTNAYGLSISLLWLLDSLICVFFLTVIVGRSKLAWDFAITIHAINFIVVFLYTRKFPSFSWFFLQILSSLILIFLGTWTTRWRELRDTFFEGLVDPNEGEVGLVTPSQQHSNHSELEQSPIQLKDLESQI", "length": 203 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55E69-1", "protein_name": "Protein SYS1 homolog", "gene_name": "sys1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFYKYNAWDPKLIIGQILSIQCLYYILLAGILYLLDSMFSSSLSLEQMFEYQSINTHSQSGRVVMTAFLINSLFGSFCLKYIVERSKKCLDHSATVTFIHFIIVWIVSGFPKTVVWWAIQLIGMVIMAMIGEYLCMRKELMDIPLQRGKDLDSTPITIPPSPHTSSPIMNPKNNSNGNSGSNNNNNNIFSNSINSSGGSSSSINSIGNSNNPYQPIELEILTHQDKQDEHDD", "length": 232 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q78S06-1", "protein_name": "Protein SYS1 homolog", "gene_name": "Sys1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDALVRSSPSLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLSSAPKSNV", "length": 156 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2H4-1", "protein_name": "Protein SYS1 homolog", "gene_name": "SYS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLNSAPKSNV", "length": 156 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHP1-1", "protein_name": "Protein SYS1 homolog", "gene_name": "Sys1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKGGTFRNTQWDPTLLSSQIVSMQFCVYFTLGLLVFVANKLSGDNYSLDHLFEYHEIHIYDMGGRLVICAFVLNAFLASLALWCIVRRAKLCLDFSCTFHVLHLLICWWYNRSFPANASWWLLNVITGTIMCIGGEFLCLQTEMKEIPVGYAALNQKSDV", "length": 160 }, "evidence": [ { "id": "Q1RMQ3", "url": "https://omabrowser.org/oma/group/Q1RMQ3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" }, { "name": "Golgi to endosome transport", "id": "GO:0006895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006895", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" }, { "name": "protein localization to Golgi apparatus", "id": "GO:0034067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034067", "evidence": [ { "database": "UniProtKB", "id": "Q1RMQ3", "url": "https://www.uniprot.org/uniprotkb/Q1RMQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMQ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 156, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMQ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMQ3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMR1-1", "uniprot_ac": "Q1RMR1", "uniprot_id": "ANGL1_BOVIN", "mass": { "chemical_mass": 56674.0, "monoisotopic_mass": 56674.0 }, "refseq": { "ac": "NP_001068894", "name": "angiopoietin-related protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894" }, "gene_names": [ { "name": "ANGPTL1", "type": "recommended", "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ] }, { "name": "ANGPTL1", "type": "synonym", "evidence": [ { "id": "NP_001068894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894" } ] } ], "protein_names": [ { "name": "Angiopoietin-related protein 1", "type": "recommended", "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1/entry#names_and_taxonomy" } ] }, { "name": "Angiopoietin-like protein 1", "type": "synonym", "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1/entry#names_and_taxonomy" } ] }, { "name": "angiopoietin-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001068894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894" } ] }, { "name": "angiopoietin-related protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001068894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894" } ] }, { "name": "angiopoietin-related protein 1", "type": "synonym", "evidence": [ { "id": "NP_001068894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANGPTL1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1", "locus": { "chromosome": "16", "start_pos": 60222330, "end_pos": 60246517, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010719", "url": "https://www.ensembl.org/id/ENSBTAG00000010719" } ] } } ], "crossref": [ { "id": "Q1RMR1", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010719", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010719", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509971", "url": "https://www.ncbi.nlm.nih.gov/gene/509971", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509971", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509971", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQHAKDA", "url": "https://omabrowser.org/oma/group/CQHAKDA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMR1", "url": "https://www.orthodb.org/?gene=Q1RMR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068894", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMR1-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAFIWTLSVLFFLLMGIGHGRGRQFKIKKITQRRYPRATDGKEDAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSKQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDPHVSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLVTSPTKSPLKIPPVTFINEGPYKDCQHAKDAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYLLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKYQDGIFWAEYRGGSYSLRAVQMLIKPID", "length": 491, "header": "sp|Q1RMR1-1|ANGL1_BOVIN Isoform 1 of Angiopoietin-related protein 1 OS=Bos taurus OX=9913 GN=ANGPTL1 PE=2 SV=1 CANONICAL=Q1RMR1-1" }, "isoforms": [ { "isoform_ac": "Q1RMR1-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1/entry#Q1RMR1-1", "sequence": { "sequence": "MKAFIWTLSVLFFLLMGIGHGRGRQFKIKKITQRRYPRATDGKEDAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSKQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDPHVSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLVTSPTKSPLKIPPVTFINEGPYKDCQHAKDAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYLLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKYQDGIFWAEYRGGSYSLRAVQMLIKPID", "length": 491, "header": "sp|Q1RMR1-1|ANGL1_BOVIN Isoform 1 of Angiopoietin-related protein 1 OS=Bos taurus OX=9913 GN=ANGPTL1 PE=2 SV=1 CANONICAL=Q1RMR1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 160, "start_aa": "Asn", "end_pos": 160, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn160", "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 188, "start_aa": "Asn", "end_pos": 188, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn188", "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509971", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509971", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K603-1", "protein_name": "Angiopoietin-like 1", "gene_name": "Angptl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTFVWILSVVLFLLGIGHCKGGQFKIKKTTQRRYPRATDGKEETKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITVLEEQCLRLFSRQDPHVSPPLVQVVPRHIPNSHQDTPGLLAGNEIQRDPGYPRDLMPPPDLATAPTKSPFKIPAVTFINEGPFKDCQQAKEAGHSASGIYMIKPENSHGPVQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLDNIYKLSNQDNYKLMIELEDWSEKKVYAEYSSFRLEPESDYYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYTGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMVKPID", "length": 490 }, "evidence": [ { "id": "Q1RMR1", "url": "https://omabrowser.org/oma/group/Q1RMR1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZJ76-1", "protein_name": "Angiopoietin like 1", "gene_name": "ANGPTL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQKDVIHAHCKMKALIWTLSVLFFLLMGIGQCRGGQFKIKKITQRRYPRATDGKEEVKKCAYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDPHLSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLATPPTKSPFKIPPVTFINEGPFKDCQHAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNTDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGIFWAEYRGGSYSLRAVQMMIKPID", "length": 502 }, "evidence": [ { "id": "Q1RMR1", "url": "https://omabrowser.org/oma/group/Q1RMR1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95841-1", "protein_name": "Angiopoietin-related protein 1", "gene_name": "ANGPTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTFTWTLGVLFFLLVDTGHCRGGQFKIKKINQRRYPRATDGKEEAKKCAYTFLVPEQRITGPICVNTKGQDASTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPLVQVVPQHIPNSQQYTPGLLGGNEIQRDPGYPRDLMPPPDLATSPTKSPFKIPPVTFINEGPFKDCQQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID", "length": 491 }, "evidence": [ { "id": "Q1RMR1", "url": "https://omabrowser.org/oma/group/Q1RMR1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q640P2-1", "protein_name": "Angiopoietin-related protein 1", "gene_name": "Angptl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKAFVWTLSVLLFLLGSGHCKGGQLKIKKITQRRYPRATDGKEEAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVTITVLEEQCLRMFSRQDPHASPPLVQVVPRHSPNSHQYTPGLLGGNEIQRDPGYPRDVMPPPDLPTAPTKSPFKIPAVTFINEGPFKDCQQAKEAGHSASGIYMIKPENSNGLMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLDNIYKLSNQDNYKLMIELEDWSEKKVYAEYSSFRLEPESDYYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDTYTGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID", "length": 490 }, "evidence": [ { "id": "Q1RMR1", "url": "https://omabrowser.org/oma/group/Q1RMR1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q1RMR1", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 491, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMR1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q1RMR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR1" }, { "id": "PRU00739", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00739" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000255", "start_pos": 271, "end_pos": 491, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 160, 188 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 }, { "start_pos": 188, "end_pos": 190 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMS0-1", "uniprot_ac": "Q1RMS0", "uniprot_id": "CCSE1_BOVIN", "mass": { "chemical_mass": 81836.0, "monoisotopic_mass": 81836.0 }, "refseq": { "ac": "NP_001069905", "name": "serine-rich coiled-coil domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" }, "gene_names": [ { "name": "CCSER1", "type": "recommended", "evidence": [ { "id": "Q1RMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0" } ] }, { "name": "CCSER1", "type": "synonym", "evidence": [ { "id": "NP_001069905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" } ] }, { "name": "FAM190A", "type": "synonym", "evidence": [ { "id": "NP_001069905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" }, { "id": "Q1RMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0" } ] } ], "protein_names": [ { "name": "Serine-rich coiled-coil domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q1RMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil serine-rich protein 1", "type": "synonym", "evidence": [ { "id": "Q1RMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 190, member A", "type": "synonym", "evidence": [ { "id": "NP_001069905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" } ] }, { "name": "protein FAM190A", "type": "synonym", "evidence": [ { "id": "NP_001069905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" } ] }, { "name": "serine-rich coiled-coil domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMS0", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCSER1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0", "locus": { "chromosome": "6", "start_pos": 33015656, "end_pos": 34501208, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019808", "url": "https://www.ensembl.org/id/ENSBTAG00000019808" } ] } } ], "crossref": [ { "id": "Q1RMS0", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "616908", "url": "https://www.ncbi.nlm.nih.gov/gene/616908", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616908", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616908", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1RMS0", "url": "https://www.orthodb.org/?gene=Q1RMS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22461:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22461:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001069905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMS0", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMS0-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSGSRRSTLVSRLPIFRRSISRKHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSLFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGQSSMQKLSLEEHTKARGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEEQTRRSVKQSTKKLLTKSFSSHYKLSKPVPQSQSISLVQQSEFSLEITQYQEREPVLVRGSPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSETDAFPKSGSMASHCDNLGHNDSTSQISPNPAAVTKTTRDLRGTVPCAIVSPGKYRLEGRCSTESNSLPETSAAYQKEVLLQITKLPVMNGSDSETHPSTDTREDHIVIQNGETMLATSSPRKFGFYEHHKAIAERVKGIHPISDSRIIPSSGDHHVLNKTSYGYDANPAKVLASSLSPYREGRFIERRLRSSSEGTAGSSRMILKPKDGNVEEVNSLRKQRASSSSSKMNSMDVLNNLGSCELDEDDLMLDLEFLEEQNLHPSVCREDSYHSVVSCAAVVLTPMEPTVEMKKREELKFREPSKQNLSLKLAKDIDQEARCSHIRGVPSSPSSDWPLPSVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVSPLAEEPLPFKDIMKDECSMLKLQLKEKDELISQLQEELEKVQHLQKAFASRVDKSTQTELLGYDALWNPTCTEGLFKPVHNIST", "length": 743, "header": "sp|Q1RMS0-1|CCSE1_BOVIN Isoform 1 of Serine-rich coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CCSER1 PE=2 SV=1 CANONICAL=Q1RMS0-1" }, "isoforms": [ { "isoform_ac": "Q1RMS0-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS0/entry#Q1RMS0-1", "sequence": { "sequence": "MGDSGSRRSTLVSRLPIFRRSISRKHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSLFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGQSSMQKLSLEEHTKARGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEEQTRRSVKQSTKKLLTKSFSSHYKLSKPVPQSQSISLVQQSEFSLEITQYQEREPVLVRGSPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSETDAFPKSGSMASHCDNLGHNDSTSQISPNPAAVTKTTRDLRGTVPCAIVSPGKYRLEGRCSTESNSLPETSAAYQKEVLLQITKLPVMNGSDSETHPSTDTREDHIVIQNGETMLATSSPRKFGFYEHHKAIAERVKGIHPISDSRIIPSSGDHHVLNKTSYGYDANPAKVLASSLSPYREGRFIERRLRSSSEGTAGSSRMILKPKDGNVEEVNSLRKQRASSSSSKMNSMDVLNNLGSCELDEDDLMLDLEFLEEQNLHPSVCREDSYHSVVSCAAVVLTPMEPTVEMKKREELKFREPSKQNLSLKLAKDIDQEARCSHIRGVPSSPSSDWPLPSVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVSPLAEEPLPFKDIMKDECSMLKLQLKEKDELISQLQEELEKVQHLQKAFASRVDKSTQTELLGYDALWNPTCTEGLFKPVHNIST", "length": 743, "header": "sp|Q1RMS0-1|CCSE1_BOVIN Isoform 1 of Serine-rich coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CCSER1 PE=2 SV=1 CANONICAL=Q1RMS0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616908", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616908", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 740, "end_pos": 742, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMS0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 743, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMS0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMS0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 290, "end_pos": 292 }, { "start_pos": 359, "end_pos": 361 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 575, "end_pos": 577 }, { "start_pos": 740, "end_pos": 742 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMS8-1", "uniprot_ac": "Q1RMS8", "uniprot_id": "FBX25_BOVIN", "mass": { "chemical_mass": 41834.0, "monoisotopic_mass": 41834.0 }, "refseq": { "ac": "NP_001069679", "name": "F-box only protein 25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069679" }, "gene_names": [ { "name": "FBXO25", "type": "recommended", "evidence": [ { "id": "Q1RMS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ] }, { "name": "FBXO25", "type": "synonym", "evidence": [ { "id": "NP_001069679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069679" } ] } ], "protein_names": [ { "name": "F-box only protein 25", "type": "recommended", "evidence": [ { "id": "Q1RMS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 25", "type": "synonym", "evidence": [ { "id": "NP_001069679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069679" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3V6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V6#function" }, { "database": "UniProtKB", "id": "ARBA00037710", "url": "https://www.uniprot.org/uniprotkb/ARBA00037710#function" }, { "database": "UniProtKB", "id": "A0AAA9TE03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE03#function" }, { "database": "UniProtKB", "id": "A0AAA9TLW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLW7#function" }, { "database": "UniProtKB", "id": "A0AAF6YR32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR32#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO25", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8", "locus": { "chromosome": "1", "start_pos": 146556373, "end_pos": 146528127, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007039", "url": "https://www.ensembl.org/id/ENSBTAG00000007039" } ] } } ], "crossref": [ { "id": "Q1RMS8", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007039", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007039", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22099", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22099", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540328", "url": "https://www.ncbi.nlm.nih.gov/gene/540328", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540328", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540328", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q1RMS8", "url": "https://www.orthodb.org/?gene=Q1RMS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13123:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13123:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27576", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27576", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3V6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3V6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMS8-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFLGQDWRSPGWSWMKTEDGWKRCDAWSQELEGENSQCDIGHGIILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 357, "header": "sp|Q1RMS8-1|FBX25_BOVIN Isoform 1 of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=2 SV=1 CANONICAL=Q1RMS8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3V6-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#A0A3Q1M3V6-1", "sequence": { "sequence": "SGGEEASGVTSLVLSIGAWTSAGQNLQGAPLCHQLESCPGILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEQVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 353, "header": "tr|A0A3Q1M3V6-1|A0A3Q1M3V6_BOVIN Computationally mapped isoform of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=4 SV=2 CANONICAL=Q1RMS8-1" }, "locus": { "chromosome": "1", "start_pos": 146555361, "end_pos": 146540109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068668.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068668.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068225.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068225.2" } ] } }, { "isoform_ac": "A0AAA9TE03-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#A0AAA9TE03-1", "sequence": { "sequence": "MPFLGQDWRSPGWSWMKTEDGWKRCDAWSQELEGENSQCDIGHGIILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEQVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDCRLALLLEDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 367, "header": "tr|A0AAA9TE03-1|A0AAA9TE03_BOVIN Computationally mapped isoform of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=4 SV=2 CANONICAL=Q1RMS8-1" }, "locus": { "chromosome": "1", "start_pos": 146555361, "end_pos": 146538428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110858.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110858.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095132.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095132.2" } ] } }, { "isoform_ac": "A0AAA9TLW7-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#A0AAA9TLW7-1", "sequence": { "sequence": "MKKYSVMKSTNLHPKKGKRTILEMTQILSRHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEQVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 291, "header": "tr|A0AAA9TLW7-1|A0AAA9TLW7_BOVIN Computationally mapped isoform of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=4 SV=1 CANONICAL=Q1RMS8-1" }, "locus": { "chromosome": "1", "start_pos": 146555361, "end_pos": 146541045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099503.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099503.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098226.1" } ] } }, { "isoform_ac": "A0AAF6YR32-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#A0AAF6YR32-1", "sequence": { "sequence": "MPFLGQDWRSPGWSWMKTEDGWKRCDAWSQELEGENSQCDIGHGIILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTREVRLGLDPEWLDERRTACRGTEWQHRHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEQVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 382, "header": "tr|A0AAF6YR32-1|A0AAF6YR32_BOVIN Computationally mapped isoform of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=4 SV=1 CANONICAL=Q1RMS8-1" }, "locus": { "chromosome": "1", "start_pos": 146555361, "end_pos": 146538428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009259.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009259.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009259.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009259.6" } ] } }, { "isoform_ac": "Q1RMS8-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8/entry#Q1RMS8-1", "sequence": { "sequence": "MPFLGQDWRSPGWSWMKTEDGWKRCDAWSQELEGENSQCDIGHGIILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY", "length": 357, "header": "sp|Q1RMS8-1|FBX25_BOVIN Isoform 1 of F-box only protein 25 OS=Bos taurus OX=9913 GN=FBXO25 PE=2 SV=1 CANONICAL=Q1RMS8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540328", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540328", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q1RMS8", "url": "https://www.uniprot.org/uniprotkb/Q1RMS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMS8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q1RMT2-1", "uniprot_ac": "Q1RMT2", "uniprot_id": "RPRM_BOVIN", "mass": { "chemical_mass": 11806.0, "monoisotopic_mass": 11806.0 }, "refseq": { "ac": "NP_001074208", "name": "protein reprimo", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074208" }, "gene_names": [ { "name": "RPRM", "type": "recommended", "evidence": [ { "id": "Q1RMT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ] }, { "name": "RPRM", "type": "synonym", "evidence": [ { "id": "NP_001074208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074208" } ] } ], "protein_names": [ { "name": "Protein reprimo", "type": "recommended", "evidence": [ { "id": "Q1RMT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2/entry#names_and_taxonomy" } ] }, { "name": "protein reprimo", "type": "synonym", "evidence": [ { "id": "NP_001074208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074208" } ] }, { "name": "reprimo, TP53 dependent G2 arrest mediator candidate", "type": "synonym", "evidence": [ { "id": "NP_001074208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074208" } ] } ], "function": [ { "annotation": "May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPRM", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2", "locus": { "chromosome": "2", "start_pos": 42652184, "end_pos": 42650738, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021526", "url": "https://www.ensembl.org/id/ENSBTAG00000021526" } ] } } ], "crossref": [ { "id": "Q1RMT2", "url": "https://alphafold.ebi.ac.uk/entry/Q1RMT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021526", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021526", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614739", "url": "https://www.ncbi.nlm.nih.gov/gene/614739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614739", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LKCCNFS", "url": "https://omabrowser.org/oma/group/LKCCNFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q1RMT2", "url": "https://www.orthodb.org/?gene=Q1RMT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28649", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28649", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28649:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28649:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001074208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074208", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q1RMT2-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNPALGNQTDVAGLFLANSSEALERAMRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109, "header": "sp|Q1RMT2-1|RPRM_BOVIN Isoform 1 of Protein reprimo OS=Bos taurus OX=9913 GN=RPRM PE=3 SV=1 CANONICAL=Q1RMT2-1" }, "isoforms": [ { "isoform_ac": "Q1RMT2-1", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2/entry#Q1RMT2-1", "sequence": { "sequence": "MNPALGNQTDVAGLFLANSSEALERAMRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109, "header": "sp|Q1RMT2-1|RPRM_BOVIN Isoform 1 of Protein reprimo OS=Bos taurus OX=9913 GN=RPRM PE=3 SV=1 CANONICAL=Q1RMT2-1" }, "locus": { "chromosome": "2", "start_pos": 42651270, "end_pos": 42650944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028688.3", "url": "https://www.ensembl.org/id/ENSBTAT00000028688.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028688.2", "url": "https://www.ensembl.org/id/ENSBTAP00000028688.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 18, "start_aa": "Asn", "end_pos": 18, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn18", "evidence": [ { "id": "Q1RMT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 7, "start_aa": "Asn", "end_pos": 7, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn7", "evidence": [ { "id": "Q1RMT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614739", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614739", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BPY9-1", "protein_name": "Reprimo, TP53 dependent G2 arrest mediator homolog", "gene_name": "RPRM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109 }, "evidence": [ { "id": "Q1RMT2", "url": "https://omabrowser.org/oma/group/Q1RMT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IBC9-1", "protein_name": "Protein reprimo", "gene_name": "Rprm", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNSVLGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109 }, "evidence": [ { "id": "Q1RMT2", "url": "https://omabrowser.org/oma/group/Q1RMT2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5BJN9-1", "protein_name": "Protein reprimo", "gene_name": "Rprm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSVLGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109 }, "evidence": [ { "id": "Q1RMT2", "url": "https://omabrowser.org/oma/group/Q1RMT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JJ72-1", "protein_name": "Protein reprimo", "gene_name": "Rprm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSVLGNQTDVAGLFLVNSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109 }, "evidence": [ { "id": "Q1RMT2", "url": "https://omabrowser.org/oma/group/Q1RMT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NS64-1", "protein_name": "Protein reprimo", "gene_name": "RPRM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY", "length": 109 }, "evidence": [ { "id": "Q1RMT2", "url": "https://omabrowser.org/oma/group/Q1RMT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "Q1RMT2", "url": "https://www.uniprot.org/uniprotkb/Q1RMT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q1RMT2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 109, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q1RMT2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q1RMT2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 7, 18 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 98 ], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24JX8-1", "uniprot_ac": "Q24JX8", "uniprot_id": "KRA31_BOVIN", "mass": { "chemical_mass": 10408.0, "monoisotopic_mass": 10408.0 }, "refseq": { "ac": "NP_001070572", "name": "keratin-associated protein 3-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070572" }, "gene_names": [ { "name": "KRTAP3-1", "type": "recommended", "evidence": [ { "id": "Q24JX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JX8" } ] }, { "name": "KRTAP3-1", "type": "synonym", "evidence": [ { "id": "NP_001070572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070572" } ] } ], "protein_names": [ { "name": "Keratin-associated protein 3-1", "type": "recommended", "evidence": [ { "id": "Q24JX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JX8/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 3-1", "type": "synonym", "evidence": [ { "id": "NP_001070572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070572" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP3-1", "url": "https://www.uniprot.org/uniprotkb/Q24JX8", "locus": { "chromosome": "19", "start_pos": 41211660, "end_pos": 41212263, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052919", "url": "https://www.ensembl.org/id/ENSBTAG00000052919" } ] } } ], "crossref": [ { "id": "Q24JX8", "url": "https://alphafold.ebi.ac.uk/entry/Q24JX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "768046", "url": "https://www.ncbi.nlm.nih.gov/gene/768046", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768046", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768046", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q24JX8", "url": "https://www.orthodb.org/?gene=Q24JX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23260:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23260:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04579", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04579", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070572", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24JX8-1", "url": "https://www.uniprot.org/uniprotkb/Q24JX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYCAPYCCSVPTGPATTICSSDKFCRCGVCLPSTCPHEISLLQPTCCDNCPPPCCVPDTYVPTCWLLNSSHPTPGLSGINLTTFVQPGCDNVCEPRC", "length": 98, "header": "sp|Q24JX8-1|KRA31_BOVIN Isoform 1 of Keratin-associated protein 3-1 OS=Bos taurus OX=9913 GN=KRTAP3-1 PE=3 SV=1 CANONICAL=Q24JX8-1" }, "isoforms": [ { "isoform_ac": "Q24JX8-1", "url": "https://www.uniprot.org/uniprotkb/Q24JX8/entry#Q24JX8-1", "sequence": { "sequence": "MAYCAPYCCSVPTGPATTICSSDKFCRCGVCLPSTCPHEISLLQPTCCDNCPPPCCVPDTYVPTCWLLNSSHPTPGLSGINLTTFVQPGCDNVCEPRC", "length": 98, "header": "sp|Q24JX8-1|KRA31_BOVIN Isoform 1 of Keratin-associated protein 3-1 OS=Bos taurus OX=9913 GN=KRTAP3-1 PE=3 SV=1 CANONICAL=Q24JX8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 74, "start_aa": "Thr", "end_pos": 74, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr74", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:768046", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768046", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q24JX8", "url": "https://www.uniprot.org/uniprotkb/Q24JX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24JX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 98, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24JX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24JX8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 74 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24JX9-1", "uniprot_ac": "Q24JX9", "uniprot_id": "KRA33_BOVIN", "mass": { "chemical_mass": 10416.0, "monoisotopic_mass": 10416.0 }, "refseq": { "ac": "NP_001070571", "name": "keratin-associated protein 3-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070571" }, "gene_names": [ { "name": "KRTAP3-3", "type": "recommended", "evidence": [ { "id": "Q24JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JX9" } ] }, { "name": "KRTAP3-3", "type": "synonym", "evidence": [ { "id": "NP_001070571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070571" } ] } ], "protein_names": [ { "name": "Keratin-associated protein 3-3", "type": "recommended", "evidence": [ { "id": "Q24JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JX9/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 3-3", "type": "synonym", "evidence": [ { "id": "NP_001070571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070571" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP3-3", "url": "https://www.uniprot.org/uniprotkb/Q24JX9", "locus": { "chromosome": "19", "start_pos": 41190862, "end_pos": 41191562, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054927", "url": "https://www.ensembl.org/id/ENSBTAG00000054927" } ] } } ], "crossref": [ { "id": "Q24JX9", "url": "https://alphafold.ebi.ac.uk/entry/Q24JX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "768045", "url": "https://www.ncbi.nlm.nih.gov/gene/768045", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768045", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768045", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCIPRNC", "url": "https://omabrowser.org/oma/group/PCIPRNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q24JX9", "url": "https://www.orthodb.org/?gene=Q24JX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23260:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23260:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04579", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04579", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070571", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24JX9-1", "url": "https://www.uniprot.org/uniprotkb/Q24JX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACCAPLCCSARTSPATTICSSDKFCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSSQPTPGLETINLTTYTQPSCEPCIPSCC", "length": 98, "header": "sp|Q24JX9-1|KRA33_BOVIN Isoform 1 of Keratin-associated protein 3-3 OS=Bos taurus OX=9913 GN=KRTAP3-3 PE=3 SV=1 CANONICAL=Q24JX9-1" }, "isoforms": [ { "isoform_ac": "Q24JX9-1", "url": "https://www.uniprot.org/uniprotkb/Q24JX9/entry#Q24JX9-1", "sequence": { "sequence": "MACCAPLCCSARTSPATTICSSDKFCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSSQPTPGLETINLTTYTQPSCEPCIPSCC", "length": 98, "header": "sp|Q24JX9-1|KRA33_BOVIN Isoform 1 of Keratin-associated protein 3-3 OS=Bos taurus OX=9913 GN=KRTAP3-3 PE=3 SV=1 CANONICAL=Q24JX9-1" }, "locus": { "chromosome": "19", "start_pos": 41191522, "end_pos": 41191229, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064111.2", "url": "https://www.ensembl.org/id/ENSBTAT00000064111.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053894.1", "url": "https://www.ensembl.org/id/ENSBTAP00000053894.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 74, "start_aa": "Thr", "end_pos": 74, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr74", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:768045", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768045", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FBK4-1", "protein_name": "4Fe-4S ferredoxin-type domain-containing protein", "gene_name": "LOC110256009", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACCVARCCSVPTGPATTICSSDKFCRCGVCLPSTCPHTTWLLEPICCDNCPPPCHIPQPCVPTCFLLNSSQPTPGLETLNLTTYVQPGGSEPCIPRCC", "length": 99 }, "evidence": [ { "id": "Q24JX9", "url": "https://omabrowser.org/oma/group/Q24JX9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZBR0-1", "protein_name": "Keratin associated protein 3-2", "gene_name": "Krtap3-2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACCVTRCCSVPTGPATTICSSDKSCRCGVCLPSTCPHTIWQLEPTCCDNCPPPCHIPQPCVPTCFLLNSCHPTPDLLTVNLTTYVQPGCEEPCTPRCC", "length": 99 }, "evidence": [ { "id": "Q24JX9", "url": "https://omabrowser.org/oma/group/Q24JX9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IGG7-1", "protein_name": "Keratin-associated protein 3-2", "gene_name": "LOC113836911", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHTIWQLEPTCCDNCPPPCHIPQPCVPTCFLLNSCHPTPDLLTVNLTTYVQPGCEDPCTPRCC", "length": 99 }, "evidence": [ { "id": "Q24JX9", "url": "https://omabrowser.org/oma/group/Q24JX9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9BYR6-1", "protein_name": "Keratin-associated protein 3-3", "gene_name": "KRTAP3-3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDCCASRGCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC", "length": 98 }, "evidence": [ { "id": "Q24JX9", "url": "https://omabrowser.org/oma/group/Q24JX9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D638-1", "protein_name": "Keratin-associated protein 3-2", "gene_name": "Krtap3-2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHTIWQLEPTCCDNCPPPCHIPQPCVPTCFLLNSCHPTPDLLTVNLTTYVQPGCEEPCVPRCC", "length": 99 }, "evidence": [ { "id": "Q24JX9", "url": "https://omabrowser.org/oma/group/Q24JX9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q24JX9", "url": "https://www.uniprot.org/uniprotkb/Q24JX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24JX9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 98, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24JX9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24JX9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 74 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24JY3-1", "uniprot_ac": "Q24JY3", "uniprot_id": "SPC24_BOVIN", "mass": { "chemical_mass": 22756.0, "monoisotopic_mass": 22756.0 }, "refseq": { "ac": "NP_001068859", "name": "kinetochore protein Spc24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" }, "gene_names": [ { "name": "SPC24", "type": "recommended", "evidence": [ { "id": "Q24JY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ] }, { "name": "SPBC24", "type": "synonym", "evidence": [ { "id": "NP_001068859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" }, { "id": "Q24JY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ] }, { "name": "SPC24", "type": "synonym", "evidence": [ { "id": "NP_001068859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" } ] } ], "protein_names": [ { "name": "Kinetochore protein Spc24", "type": "recommended", "evidence": [ { "id": "Q24JY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY3/entry#names_and_taxonomy" } ] }, { "name": "SPC24, NDC80 kinetochore complex component, homolog", "type": "synonym", "evidence": [ { "id": "NP_001068859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" } ] }, { "name": "kinetochore protein Spc24", "type": "synonym", "evidence": [ { "id": "NP_001068859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" } ] }, { "name": "spindle pole body component 24 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859" } ] } ], "function": [ { "annotation": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3#function" }, { "database": "UniProtKB", "id": "Q8NBT2", "url": "https://www.uniprot.org/uniprotkb/Q8NBT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPC24", "url": "https://www.uniprot.org/uniprotkb/Q24JY3", "locus": { "chromosome": "7", "start_pos": 15588142, "end_pos": 15594352, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006185", "url": "https://www.ensembl.org/id/ENSBTAG00000006185" } ] } } ], "crossref": [ { "id": "Q24JY3", "url": "https://alphafold.ebi.ac.uk/entry/Q24JY3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11565", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11565", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509117", "url": "https://www.ncbi.nlm.nih.gov/gene/509117", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509117", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509117", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q24JY3", "url": "https://www.orthodb.org/?gene=Q24JY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22142:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22142:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08286", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08286", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24JY3-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAFRDMEEVSQGLLSLLGANRAEAQQRRLLGRHEQKVERLLETQDGAEKWLREILTTEKEVAQRLLDAKEQAHQGGVEVRQLEAELQRASEEDAHLKANLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYRRISKIEWDYECEPGMIKGIHHGPSVAQPIHLDSTQLSKKFISDYLWNLVDTEW", "length": 197, "header": "sp|Q24JY3-1|SPC24_BOVIN Isoform 1 of Kinetochore protein Spc24 OS=Bos taurus OX=9913 GN=SPC24 PE=2 SV=1 CANONICAL=Q24JY3-1" }, "isoforms": [ { "isoform_ac": "Q24JY3-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY3/entry#Q24JY3-1", "sequence": { "sequence": "MAAFRDMEEVSQGLLSLLGANRAEAQQRRLLGRHEQKVERLLETQDGAEKWLREILTTEKEVAQRLLDAKEQAHQGGVEVRQLEAELQRASEEDAHLKANLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYRRISKIEWDYECEPGMIKGIHHGPSVAQPIHLDSTQLSKKFISDYLWNLVDTEW", "length": 197, "header": "sp|Q24JY3-1|SPC24_BOVIN Isoform 1 of Kinetochore protein Spc24 OS=Bos taurus OX=9913 GN=SPC24 PE=2 SV=1 CANONICAL=Q24JY3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "site_lbl": "Ser11" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509117", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509117", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Ndc80 complex", "id": "GO:0031262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031262", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q24JY3", "url": "https://www.uniprot.org/uniprotkb/Q24JY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24JY3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24JY3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24JY3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24JY6-1", "uniprot_ac": "Q24JY6", "uniprot_id": "TM160_BOVIN", "mass": { "chemical_mass": 19465.0, "monoisotopic_mass": 19465.0 }, "refseq": { "ac": "NP_001039484", "name": "transmembrane protein 160 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039484" }, "gene_names": [ { "name": "TMEM160", "type": "recommended", "evidence": [ { "id": "Q24JY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY6" } ] }, { "name": "TMEM160", "type": "synonym", "evidence": [ { "id": "NP_001039484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039484" } ] } ], "protein_names": [ { "name": "Transmembrane protein 160", "type": "recommended", "evidence": [ { "id": "Q24JY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY6/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 160 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039484" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24JY6", "url": "https://www.uniprot.org/uniprotkb/Q24JY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM160", "url": "https://www.uniprot.org/uniprotkb/Q24JY6", "locus": { "chromosome": "18", "start_pos": 54094494, "end_pos": 54096944, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015579", "url": "https://www.ensembl.org/id/ENSBTAG00000015579" } ] } } ], "crossref": [ { "id": "Q24JY6", "url": "https://alphafold.ebi.ac.uk/entry/Q24JY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "508953", "url": "https://www.ncbi.nlm.nih.gov/gene/508953", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508953", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508953", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WWARARL", "url": "https://omabrowser.org/oma/group/WWARARL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q24JY6", "url": "https://www.orthodb.org/?gene=Q24JY6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16236:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16236:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039484", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24JY6", "url": "https://www.uniprot.org/uniprotkb/Q24JY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24JY6-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGGWWWARAARLARLRFRGALLPPPRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGGASYVVGLAALRGPMQLSVGGAAAGVGAVLAAGLLWACAVGLYMGQLELDVELVPEDDGTTAAEGPDEAGRPPPE", "length": 188, "header": "sp|Q24JY6-1|TM160_BOVIN Isoform 1 of Transmembrane protein 160 OS=Bos taurus OX=9913 GN=TMEM160 PE=2 SV=1 CANONICAL=Q24JY6-1" }, "isoforms": [ { "isoform_ac": "Q24JY6-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY6/entry#Q24JY6-1", "sequence": { "sequence": "MGGGWWWARAARLARLRFRGALLPPPRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGGASYVVGLAALRGPMQLSVGGAAAGVGAVLAAGLLWACAVGLYMGQLELDVELVPEDDGTTAAEGPDEAGRPPPE", "length": 188, "header": "sp|Q24JY6-1|TM160_BOVIN Isoform 1 of Transmembrane protein 160 OS=Bos taurus OX=9913 GN=TMEM160 PE=2 SV=1 CANONICAL=Q24JY6-1" }, "locus": { "chromosome": "18", "start_pos": 54096934, "end_pos": 54094570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020695.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020695.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020695.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020695.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24JY6", "url": "https://www.uniprot.org/uniprotkb/Q24JY6" } ], "site_lbl": "Ser48" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508953", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508953", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RM05-1", "protein_name": "Transmembrane protein 160", "gene_name": "TMEM160", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGGWWWARAARLARLRFRGALLPPPRPRSGGARGSFAPGHGPRSGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGGASYVVGLAALRGPMQLSLGGAAAGVGAVLAAGLLWACAVGLYMGQLELDVELVPEDDGTAAAEGPDEAGRPPPE", "length": 188 }, "evidence": [ { "id": "Q24JY6", "url": "https://omabrowser.org/oma/group/Q24JY6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D938-1", "protein_name": "Transmembrane protein 160", "gene_name": "Tmem160", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGGWWWARVARLARLRFRGSLQPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLSSGIGVISFMQSDMGREAAYGFFLLGGLCVVWGGASYAVGLAALRGPMQLSLAGAAAGVGAVLAASLLWACAVGLYMGQLELDVELVPEDDGAASTEGPDEAGRPPPE", "length": 188 }, "evidence": [ { "id": "Q24JY6", "url": "https://omabrowser.org/oma/group/Q24JY6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX00-1", "protein_name": "Transmembrane protein 160", "gene_name": "TMEM160", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGSASYAVGLAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQLELDVELVPEDDGTASAEGPDEAGRPPPE", "length": 188 }, "evidence": [ { "id": "Q24JY6", "url": "https://omabrowser.org/oma/group/Q24JY6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q24JY6", "url": "https://www.uniprot.org/uniprotkb/Q24JY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24JY6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24JY6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24JY6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 48 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24JY8-1", "uniprot_ac": "Q24JY8", "uniprot_id": "C2AIL_BOVIN", "mass": { "chemical_mass": 13238.0, "monoisotopic_mass": 13238.0 }, "refseq": { "ac": "NP_001039577", "name": "CDKN2AIP N-terminal-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039577" }, "gene_names": [ { "name": "CDKN2AIPNL", "type": "recommended", "evidence": [ { "id": "Q24JY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY8" } ] }, { "name": "CDKN2AIPNL", "type": "synonym", "evidence": [ { "id": "NP_001039577", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039577" } ] } ], "protein_names": [ { "name": "CDKN2AIP N-terminal-like protein", "type": "recommended", "evidence": [ { "id": "Q24JY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY8/entry#names_and_taxonomy" } ] }, { "name": "CDKN2A-interacting protein N-terminal-like protein", "type": "synonym", "evidence": [ { "id": "NP_001039577", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039577" }, { "id": "Q24JY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY8/entry#names_and_taxonomy" } ] }, { "name": "CDKN2AIP N-terminal-like protein", "type": "synonym", "evidence": [ { "id": "NP_001039577", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039577" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24JY8", "url": "https://www.uniprot.org/uniprotkb/Q24JY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDKN2AIPNL", "url": "https://www.uniprot.org/uniprotkb/Q24JY8", "locus": { "chromosome": "7", "start_pos": 45942492, "end_pos": 45972754, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010984", "url": "https://www.ensembl.org/id/ENSBTAG00000010984" } ] } } ], "crossref": [ { "id": "Q24JY8", "url": "https://alphafold.ebi.ac.uk/entry/Q24JY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010984", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010984", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512206", "url": "https://www.ncbi.nlm.nih.gov/gene/512206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512206", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512206", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SDKHWEA", "url": "https://omabrowser.org/oma/group/SDKHWEA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q24JY8", "url": "https://www.orthodb.org/?gene=Q24JY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF11952", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11952", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039577", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24JY8", "url": "https://www.uniprot.org/uniprotkb/Q24JY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24JY8-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS", "length": 116, "header": "sp|Q24JY8-1|C2AIL_BOVIN Isoform 1 of CDKN2AIP N-terminal-like protein OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=Q24JY8-1" }, "isoforms": [ { "isoform_ac": "Q24JY8-1", "url": "https://www.uniprot.org/uniprotkb/Q24JY8/entry#Q24JY8-1", "sequence": { "sequence": "MVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS", "length": 116, "header": "sp|Q24JY8-1|C2AIL_BOVIN Isoform 1 of CDKN2AIP N-terminal-like protein OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=Q24JY8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512206", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512206", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ACW8-1", "protein_name": "CDKN2A interacting protein N-terminal like", "gene_name": "CDKN2AIPNL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVGGEAAAAVEELVSGVRQATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDVPQFTTRSELMKKHQS", "length": 116 }, "evidence": [ { "id": "Q24JY8", "url": "https://omabrowser.org/oma/group/Q24JY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RK03-1", "protein_name": "CDKN2AIP N-terminal-like protein", "gene_name": "Cdkn2aipnl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGGEATSAVEKLVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTSRSELMKKHQS", "length": 116 }, "evidence": [ { "id": "Q24JY8", "url": "https://omabrowser.org/oma/group/Q24JY8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96HQ2-1", "protein_name": "CDKN2AIP N-terminal-like protein", "gene_name": "CDKN2AIPNL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVGGEAAAAVEELVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGSGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS", "length": 116 }, "evidence": [ { "id": "Q24JY8", "url": "https://omabrowser.org/oma/group/Q24JY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D211-1", "protein_name": "CDKN2AIP N-terminal-like protein", "gene_name": "Cdkn2aipnl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGGEASAAVEKLVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMRKHQS", "length": 116 }, "evidence": [ { "id": "Q24JY8", "url": "https://omabrowser.org/oma/group/Q24JY8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24JY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 116, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24JY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24JY8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q24JY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24JY8" }, { "id": "PRU01171", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "XRN2-binding (XTBD)", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 116, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24K03-1", "uniprot_ac": "Q24K03", "uniprot_id": "THUM1_BOVIN", "mass": { "chemical_mass": 39754.0, "monoisotopic_mass": 39754.0 }, "refseq": { "ac": "NP_001039742", "name": "THUMP domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039742" }, "gene_names": [ { "name": "THUMPD1", "type": "recommended", "evidence": [ { "id": "Q24K03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ] }, { "name": "THUMPD1", "type": "synonym", "evidence": [ { "id": "NP_001039742", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039742" } ] } ], "protein_names": [ { "name": "THUMP domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q24K03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K03/entry#names_and_taxonomy" } ] }, { "name": "THUMP domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039742", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039742" } ] } ], "function": [ { "annotation": "Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C).", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03#function" }, { "database": "UniProtKB", "id": "Q9NXG2", "url": "https://www.uniprot.org/uniprotkb/Q9NXG2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THUMPD1", "url": "https://www.uniprot.org/uniprotkb/Q24K03", "locus": { "chromosome": "25", "start_pos": 18452580, "end_pos": 18457021, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047673", "url": "https://www.ensembl.org/id/ENSBTAG00000047673" } ] } } ], "crossref": [ { "id": "Q24K03", "url": "https://alphafold.ebi.ac.uk/entry/Q24K03", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047673", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047673", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524854", "url": "https://www.ncbi.nlm.nih.gov/gene/524854", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524854", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524854", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNEKACV", "url": "https://omabrowser.org/oma/group/MNEKACV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q24K03", "url": "https://www.orthodb.org/?gene=Q24K03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13452:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13452:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039742", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24K03-1", "url": "https://www.uniprot.org/uniprotkb/Q24K03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARIQQSPQPGGGKRKGKAQYVQAKRARRWDGGGPRQLEPGIQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKFADKDQQPSGSEGEDDDVEAALKKEVGDIKASTEMRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDIYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLSNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSAKDLSQLNPKQAAQTGNGKEAKLESGDKSSQNDPAEGKNNQQVVPENSEELGPTESISETHVVNEGVAKPELASQVTEGSESNENDL", "length": 357, "header": "sp|Q24K03-1|THUM1_BOVIN Isoform 1 of THUMP domain-containing protein 1 OS=Bos taurus OX=9913 GN=THUMPD1 PE=2 SV=1 CANONICAL=Q24K03-1" }, "isoforms": [ { "isoform_ac": "Q24K03-1", "url": "https://www.uniprot.org/uniprotkb/Q24K03/entry#Q24K03-1", "sequence": { "sequence": "MAARIQQSPQPGGGKRKGKAQYVQAKRARRWDGGGPRQLEPGIQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKFADKDQQPSGSEGEDDDVEAALKKEVGDIKASTEMRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDIYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLSNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSAKDLSQLNPKQAAQTGNGKEAKLESGDKSSQNDPAEGKNNQQVVPENSEELGPTESISETHVVNEGVAKPELASQVTEGSESNENDL", "length": 357, "header": "sp|Q24K03-1|THUM1_BOVIN Isoform 1 of THUMP domain-containing protein 1 OS=Bos taurus OX=9913 GN=THUMPD1 PE=2 SV=1 CANONICAL=Q24K03-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 119, "end_pos": 119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "site_lbl": "Ser119" }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "site_lbl": "Ser270" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "site_lbl": "Ser86" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "site_lbl": "Ser88" }, { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "site_lbl": "Ser8" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524854", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524854", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P53072-1", "protein_name": "tRNA acetyltransferase TAN1", "gene_name": "TAN1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGEKRNRNGKDANSQNRKKFKVSSGFLDPGTSGIYATCSRRHERQAAQELQLLFEEKFQELYGDIKEGEDESENDEKKDLSIEDQIKKELQELKGEETGKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPITYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFNTIERMDIINQVVKLVNKEGSEFNHTVDLKNYDKLILVECFKSNIGMCVVDGDYKTKYRKYNVQQLYESKFRKDEDKSVKQ", "length": 289 }, "evidence": [ { "id": "Q24K03", "url": "https://omabrowser.org/oma/group/Q24K03/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54DZ0-1", "protein_name": "THUMP domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSENNELKRKIENENDENDENKKKLKDNEKEEEEEKKDEVELENKEKSKKGKKKEEKEESSLPSTLKPSKAVLNDPIFGQPGLLFTFGNGREVQATKDLYNLLNEYVNENNNNNNNKNDNNDDFDFNKAFEQELQQVKETTGKSAPYKKYTLKCNGIAFMAFKENSNIDPISLTSRIFKDCETSKTLKTKEISRLIPISKFIHLSNMMEEIKILIDKYFCDPIEKIIKYKIEFKSRNNEKINKMEYIQEIAKLINPNHKVDLNNPELTIIIEIIKFYCGVSIVSNYNECKRFNLVGLAGLLQPTPKKKNKENPKQNNHDENEKEDEKEDEREDGKESDK", "length": 339 }, "evidence": [ { "id": "Q24K03", "url": "https://omabrowser.org/oma/group/Q24K03/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q99J36-1", "protein_name": "THUMP domain-containing protein 1", "gene_name": "Thumpd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATTAQQSPQPVAGKRKGKSQFLPAKRARRGDAGGPRQLEPGLQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKFIDKDQQPSGSEGEDDDAEAALKKEVGDIKASTEKRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLTNPEYTVVVEIIKAVCCLSVVKDYVLFRKYNLQEVVKSAKDSQPHPKLGNGKEAKLEPDSKLSQSDPPEGNQVAPESIEELGQTEPGSETQAGSEGDAKPEPESQVSEVPKTNENELS", "length": 350 }, "evidence": [ { "id": "Q24K03", "url": "https://omabrowser.org/oma/group/Q24K03/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NXG2-1", "protein_name": "THUMP domain-containing protein 1", "gene_name": "THUMPD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPAQQTTQPGGGKRKGKAQYVLAKRARRCDAGGPRQLEPGLQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKFTDKDQQPSGSEGEDDDAEAALKKEVGDIKASTEMRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHVNREEVIRELAGIVCTLNSENKVDLTNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSPKDPSQLNSKQGNGKEAKLESADKSDQNNTAEGKNNQQVPENTEELGQTKPTSNPQVVNEGGAKPELASQATEGSKSNENDFS", "length": 353 }, "evidence": [ { "id": "Q24K03", "url": "https://omabrowser.org/oma/group/Q24K03/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "Q24K03", "url": "https://www.uniprot.org/uniprotkb/Q24K03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24K03-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24K03-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24K03" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q24K03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K03" }, { "id": "PRU00529", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00529" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THUMP", "eco_id": "ECO_0000255", "start_pos": 147, "end_pos": 254, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 8, 86, 88, 119, 270 ], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24K06-1", "uniprot_ac": "Q24K06", "uniprot_id": "LRC10_BOVIN", "mass": { "chemical_mass": 31760.0, "monoisotopic_mass": 31760.0 }, "refseq": { "ac": "NP_001069225", "name": "leucine-rich repeat-containing protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069225" }, "gene_names": [ { "name": "LRRC10", "type": "recommended", "evidence": [ { "id": "Q24K06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ] }, { "name": "LRRC10", "type": "synonym", "evidence": [ { "id": "NP_001069225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069225" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 10", "type": "recommended", "evidence": [ { "id": "Q24K06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K06/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 10", "type": "synonym", "evidence": [ { "id": "NP_001069225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069225" } ] } ], "function": [ { "annotation": "May play important roles in cardiac development and/or cardiac function.", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC10", "url": "https://www.uniprot.org/uniprotkb/Q24K06", "locus": { "chromosome": "5", "start_pos": 43866402, "end_pos": 43863320, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019157", "url": "https://www.ensembl.org/id/ENSBTAG00000019157" } ] } } ], "crossref": [ { "id": "Q24K06", "url": "https://alphafold.ebi.ac.uk/entry/Q24K06", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019157", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019157", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517750", "url": "https://www.ncbi.nlm.nih.gov/gene/517750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LWIESNC", "url": "https://omabrowser.org/oma/group/LWIESNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q24K06", "url": "https://www.orthodb.org/?gene=Q24K06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069225", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24K06-1", "url": "https://www.uniprot.org/uniprotkb/Q24K06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTIRAFVAFIPADRCQNYVARDLREMPLDRMVDLSGSQLRRFPVHVCSFQELVKLYLSDNRLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPRELSLLQNLRTLWVEANYLTKLPEVVCELSLLKTLHAGSNALRLLPGQLQRLRELRTIWLSGNLLTDFPPVLLHMPFLEIIDVDRNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALAREESQEAQLPALPPLPPTNS", "length": 278, "header": "sp|Q24K06-1|LRC10_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 10 OS=Bos taurus OX=9913 GN=LRRC10 PE=2 SV=1 CANONICAL=Q24K06-1" }, "isoforms": [ { "isoform_ac": "Q24K06-1", "url": "https://www.uniprot.org/uniprotkb/Q24K06/entry#Q24K06-1", "sequence": { "sequence": "MGNTIRAFVAFIPADRCQNYVARDLREMPLDRMVDLSGSQLRRFPVHVCSFQELVKLYLSDNRLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPRELSLLQNLRTLWVEANYLTKLPEVVCELSLLKTLHAGSNALRLLPGQLQRLRELRTIWLSGNLLTDFPPVLLHMPFLEIIDVDRNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALAREESQEAQLPALPPLPPTNS", "length": 278, "header": "sp|Q24K06-1|LRC10_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 10 OS=Bos taurus OX=9913 GN=LRRC10 PE=2 SV=1 CANONICAL=Q24K06-1" }, "locus": { "chromosome": "5", "start_pos": 43864192, "end_pos": 43863359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025497.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025497.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025497.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025497.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517750", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0PUJ4-1", "protein_name": "Leucine rich repeat containing 10", "gene_name": "LRRC10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "GNTIRALVAFIPADRCQKYVVRDLQEMPLDKMVDLSGNQLRRFPVHVCSFQELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKVLPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWVEANYLTQLPDVVCELSLLKTLHAGSNALRLLPGQLQRLQELRTIWLSGNLLTDFPPVLLHMPFLEVIDVDQNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQEAQVPALLPPFPPTNS", "length": 278 }, "evidence": [ { "id": "Q24K06", "url": "https://omabrowser.org/oma/group/Q24K06/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YGZ4-1", "protein_name": "Leucine rich repeat containing 10", "gene_name": "LRRC10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGNSLKAVVAFVPSDECQKYLLEDLEEMPVDKMVDLSGRQLRRLPLHICSFRELVKLYLSNNNLTQLPPELEQLQNLQILALDFNNFRALPLAVCTLKQLCILYLGNNKLCSLPLELRLLQNLRTLWIESNCLQQLPEVVCELSLLKTLHAGSNALRTLPTRLRGLCELRSIWLSGNLLAEFPSVLLHMPSLEVIDVDRNAIRYFPSLAHLASLKLVIYDHNPCRNAPKVAKGVRRVGRWSEESPEPRKRSGAVIEISLSERPLPPPASKAEPEAEAC", "length": 278 }, "evidence": [ { "id": "Q24K06", "url": "https://omabrowser.org/oma/group/Q24K06/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4AAU8-1", "protein_name": "Leucine-rich repeat-containing protein 10", "gene_name": "Lrrc10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNIIRALVAFIPTDRCQSYVVGDLREMPLDRMVDLSGSQLRRFPLHVCSFTELVKLYLSDNHLHSLPPDLAQLQNLQILALDFNNFKALPQAVCTLKQLCILYLGNNKLCDLPDELSLLQNLRTLWLESNCLTRLPDVVCELSLLKTLHAGSNALRLLPGQLRRLRELRTIWLSGNQLADFPSVLLHMPFLEVIDVDRNSIRYFPSLAHLTNLKLVIYDHNPCRNAPKVGKGVRRVGRWAEETPEPDRRKTRRSALAKEENQEPPPLLPPSS", "length": 273 }, "evidence": [ { "id": "Q24K06", "url": "https://omabrowser.org/oma/group/Q24K06/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5BKY1-1", "protein_name": "Leucine-rich repeat-containing protein 10", "gene_name": "LRRC10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS", "length": 277 }, "evidence": [ { "id": "Q24K06", "url": "https://omabrowser.org/oma/group/Q24K06/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K3W2-1", "protein_name": "Leucine-rich repeat-containing protein 10", "gene_name": "Lrrc10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNTIRAFVAFIPTDRCQSYVVGDLREMPLDRMVDLSGSQLRRFPLHVCSFTELVKLYLSDNHLHSLPPDLAQLQNLQILALDFNNFKALPRVVCTLKQLCILYLGNNKLCDLPDELSLLQNLRTLWLESNCLTRLPDVVCELSLLKTLHAGSNALRLLPGQLRRLRELRTIWLSGNQLADFPSVLLRMPFLEVIDVDRNSIRYFPSLAHLTNLKLVIYDHNPCRNAPKVGKGVRRVGRWAEETPEPDPRKARRYALAKEENQEPPPPLLPSSS", "length": 274 }, "evidence": [ { "id": "Q24K06", "url": "https://omabrowser.org/oma/group/Q24K06/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" }, { "name": "alpha-actinin binding", "id": "GO:0051393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051393", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" }, { "name": "sarcomere", "id": "GO:0030017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "Q24K06", "url": "https://www.uniprot.org/uniprotkb/Q24K06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24K06-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24K06-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24K06" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q24K12-1", "uniprot_ac": "Q24K12", "uniprot_id": "GPTC1_BOVIN", "mass": { "chemical_mass": 103602.0, "monoisotopic_mass": 103602.0 }, "refseq": { "ac": "NP_001069246", "name": "G patch domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069246" }, "gene_names": [ { "name": "GPATCH1", "type": "recommended", "evidence": [ { "id": "Q24K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ] }, { "name": "GPATC1", "type": "synonym", "evidence": [ { "id": "NP_001069246", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069246" }, { "id": "Q24K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ] }, { "name": "GPATCH1", "type": "synonym", "evidence": [ { "id": "NP_001069246", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069246" } ] } ], "protein_names": [ { "name": "G patch domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q24K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K12/entry#names_and_taxonomy" } ] }, { "name": "G patch domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069246", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069246" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPATCH1", "url": "https://www.uniprot.org/uniprotkb/Q24K12", "locus": { "chromosome": "18", "start_pos": 43544122, "end_pos": 43488409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000721", "url": "https://www.ensembl.org/id/ENSBTAG00000000721" } ] } } ], "crossref": [ { "id": "Q24K12", "url": "https://alphafold.ebi.ac.uk/entry/Q24K12", "database": "AlphaFoldDB", "categories": [] }, { "id": "518738", "url": "https://www.ncbi.nlm.nih.gov/gene/518738", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518738", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518738", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q24K12", "url": "https://www.orthodb.org/?gene=Q24K12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13384:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13384:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07713", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07713", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069246", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24K12-1", "url": "https://www.uniprot.org/uniprotkb/Q24K12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALDSDSDEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEGWTPSSFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKSIVTTDDFASKTKDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGIGPRVKRRPRRQKPDPGVKIYGCALPPGGSEGSEDEDDDYLPENVTFAPKDVTPVDFTPKDNVHGLAYKGLDPHQALFGTSGEHFNLFSGGPEETGDLLGDIGVNKGRKLGISGQAFGVGALEEEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPRQYKSQKESEKDLCYVGKILDGFSLASKPLSSKKIYPPPELPRDYRPVHYFRPVVAATSENSHLLQVLSESAGKPTNDPGTRSRHQLNACKRGELLGETPIQGAPTSVLEFLSQKDKERLKEVKQATDLKAAQLRARSLAQSASGSRPQPLSPDVGHCSWHMALSGGMASTRTSNFKPFAKDPEKQKRYEEFLANMKRGQKDALERCLDPGMTEWERGRERDEFARAALLYASSHSTLSSRFTHAQEEDDSEQVEVPRDQENDVSDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTIPETASSPVTQASSEKVAQHRASDKSRKPSRWDTSKEEKKEDSISEFLSLARSKVGPAKPEPSPLVNKEEARATESVSNKVVNKDVDSQTEGEGSRPSMDLFKAIFASSSDEKSSSSEDEQGDSEDDQEGTREADFKSSQETDLVEASSVAQASEPAPQEPAPFFPIQKMQIDEREAFGPRLPPVFCPNARQKLEAPLKEKHKKNKEKHKTKKEHRRKKEKKKKHRKHKHKGKQKNKKSEKSSSSESTDSSDSQSEEGPTDLSPQELLRRLKRLPLRRQ", "length": 931, "header": "sp|Q24K12-1|GPTC1_BOVIN Isoform 1 of G patch domain-containing protein 1 OS=Bos taurus OX=9913 GN=GPATCH1 PE=2 SV=1 CANONICAL=Q24K12-1" }, "isoforms": [ { "isoform_ac": "Q24K12-1", "url": "https://www.uniprot.org/uniprotkb/Q24K12/entry#Q24K12-1", "sequence": { "sequence": "MAALDSDSDEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEGWTPSSFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKSIVTTDDFASKTKDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGIGPRVKRRPRRQKPDPGVKIYGCALPPGGSEGSEDEDDDYLPENVTFAPKDVTPVDFTPKDNVHGLAYKGLDPHQALFGTSGEHFNLFSGGPEETGDLLGDIGVNKGRKLGISGQAFGVGALEEEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPRQYKSQKESEKDLCYVGKILDGFSLASKPLSSKKIYPPPELPRDYRPVHYFRPVVAATSENSHLLQVLSESAGKPTNDPGTRSRHQLNACKRGELLGETPIQGAPTSVLEFLSQKDKERLKEVKQATDLKAAQLRARSLAQSASGSRPQPLSPDVGHCSWHMALSGGMASTRTSNFKPFAKDPEKQKRYEEFLANMKRGQKDALERCLDPGMTEWERGRERDEFARAALLYASSHSTLSSRFTHAQEEDDSEQVEVPRDQENDVSDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTIPETASSPVTQASSEKVAQHRASDKSRKPSRWDTSKEEKKEDSISEFLSLARSKVGPAKPEPSPLVNKEEARATESVSNKVVNKDVDSQTEGEGSRPSMDLFKAIFASSSDEKSSSSEDEQGDSEDDQEGTREADFKSSQETDLVEASSVAQASEPAPQEPAPFFPIQKMQIDEREAFGPRLPPVFCPNARQKLEAPLKEKHKKNKEKHKTKKEHRRKKEKKKKHRKHKHKGKQKNKKSEKSSSSESTDSSDSQSEEGPTDLSPQELLRRLKRLPLRRQ", "length": 931, "header": "sp|Q24K12-1|GPTC1_BOVIN Isoform 1 of G patch domain-containing protein 1 OS=Bos taurus OX=9913 GN=GPATCH1 PE=2 SV=1 CANONICAL=Q24K12-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 358, "end_pos": 358, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "site_lbl": "Ser358" }, { "start_pos": 479, "end_pos": 479, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "site_lbl": "Ser479" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "site_lbl": "Ser6" }, { "start_pos": 715, "end_pos": 715, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "site_lbl": "Ser715" }, { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "site_lbl": "Ser8" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:518738", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518738", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q24K12", "url": "https://www.uniprot.org/uniprotkb/Q24K12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q24K12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 931, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q24K12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q24K12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q24K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K12" }, { "id": "PRU00092", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00092" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000255", "start_pos": 152, "end_pos": 198, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 6, 8, 358, 479, 715 ], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q27976-1", "uniprot_ac": "Q27976", "uniprot_id": "CALD1_BOVIN", "mass": { "chemical_mass": 9920.0, "monoisotopic_mass": 9920.0 }, "refseq": {}, "gene_names": [ { "name": "CALD1", "type": "recommended", "evidence": [ { "id": "Q27976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ] } ], "protein_names": [ { "name": "Non-muscle caldesmon", "type": "recommended", "evidence": [ { "id": "Q27976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27976/entry#names_and_taxonomy" } ] }, { "name": "CDM", "type": "synonym", "evidence": [ { "id": "Q27976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27976/entry#names_and_taxonomy" } ] }, { "name": "L-caldesmon", "type": "synonym", "evidence": [ { "id": "Q27976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27976/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping.", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CALD1", "url": "https://www.uniprot.org/uniprotkb/Q27976", "locus": { "chromosome": "4", "start_pos": 98679000, "end_pos": 98573627, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013953", "url": "https://www.ensembl.org/id/ENSBTAG00000013953" } ] } } ], "crossref": [ { "id": "Q27976", "url": "https://alphafold.ebi.ac.uk/entry/Q27976", "database": "AlphaFoldDB", "categories": [] }, { "id": "Q27976", "url": "https://www.orthodb.org/?gene=Q27976", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q27976-1", "url": "https://www.uniprot.org/uniprotkb/Q27976-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QTSEKEGRSESRQERQELEETEIVTKSHQKNDWMEAEEKKKEEKEKEEEEEEKPKPGSIEENQLKDEKTKKDKESKNILSLCL", "length": 83, "header": "sp|Q27976-1|CALD1_BOVIN Isoform 1 of Non-muscle caldesmon OS=Bos taurus OX=9913 GN=CALD1 PE=2 SV=1 CANONICAL=Q27976-1" }, "isoforms": [ { "isoform_ac": "Q27976-1", "url": "https://www.uniprot.org/uniprotkb/Q27976/entry#Q27976-1", "sequence": { "sequence": "QTSEKEGRSESRQERQELEETEIVTKSHQKNDWMEAEEKKKEEKEKEEEEEEKPKPGSIEENQLKDEKTKKDKESKNILSLCL", "length": 83, "header": "sp|Q27976-1|CALD1_BOVIN Isoform 1 of Non-muscle caldesmon OS=Bos taurus OX=9913 GN=CALD1 PE=2 SV=1 CANONICAL=Q27976-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1994", "authors": "Aiello L P, Robinson G S, Lin Y W, Nishio Y, King G L", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "reference": [ { "type": "PubMed", "id": "8016144", "url": "https://glygen.org/publication/PubMed/8016144" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "Q27976", "url": "https://www.uniprot.org/uniprotkb/Q27976" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q27976-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 83, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q27976-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q27976" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q28008-1", "uniprot_ac": "Q28008", "uniprot_id": "CLC3A_BOVIN", "mass": { "chemical_mass": 22216.0, "monoisotopic_mass": 22216.0 }, "refseq": { "ac": "NP_777058", "name": "C-type lectin domain family 3 member A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" }, "gene_names": [ { "name": "CLEC3A", "type": "recommended", "evidence": [ { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ] }, { "name": "CLEC3A", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" } ] }, { "name": "CLECSF1", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" }, { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 3 member A", "type": "recommended", "evidence": [ { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008/entry#names_and_taxonomy" } ] }, { "name": "C-type lectin domain family 3 member A precursor", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" } ] }, { "name": "C-type lectin superfamily member 1", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" }, { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008/entry#names_and_taxonomy" } ] }, { "name": "Cartilage-derived C-type lectin", "type": "synonym", "evidence": [ { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008/entry#names_and_taxonomy" } ] }, { "name": "cartilage-derived C-type lectin", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" } ] }, { "name": "domain) lectin, superfamily member 1(cartilage-derived)", "type": "synonym", "evidence": [ { "id": "NP_777058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058" } ] } ], "function": [ { "annotation": "Promotes cell adhesion to laminin and fibronectin.", "evidence": [ { "database": "UniProtKB", "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC3A", "url": "https://www.uniprot.org/uniprotkb/Q28008", "locus": { "chromosome": "18", "start_pos": 5210890, "end_pos": 5201404, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046772", "url": "https://www.ensembl.org/id/ENSBTAG00000046772" } ] } } ], "crossref": [ { "id": "Q28008", "url": "https://alphafold.ebi.ac.uk/entry/Q28008", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046772", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046772", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03596", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03596", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282415", "url": "https://www.ncbi.nlm.nih.gov/gene/282415", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282415", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282415", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYICEFL", "url": "https://omabrowser.org/oma/group/RYICEFL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q28008", "url": "https://www.orthodb.org/?gene=Q28008", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22799", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22799", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22799:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22799:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777058", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q28008-1", "url": "https://www.uniprot.org/uniprotkb/Q28008-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKNGLVIYILVITLLLDQTSCHASKFKARKHSKRRVKEKDGDLKTQVEKLWREVNALKEMQALQTVCLRGTKFHKKCYLAAEGLKHFHEANEDCISKGGTLVVPRSADEINALRDYGKRSLPGVNDFWLGINDMVAEGKFVDINGLAISFLNWDQAQPNGGKRENCALFSQSAQGKWSDEACHSSKRYICEFTIPQ", "length": 197, "header": "sp|Q28008-1|CLC3A_BOVIN Isoform 1 of C-type lectin domain family 3 member A OS=Bos taurus OX=9913 GN=CLEC3A PE=2 SV=1 CANONICAL=Q28008-1" }, "isoforms": [ { "isoform_ac": "Q28008-1", "url": "https://www.uniprot.org/uniprotkb/Q28008/entry#Q28008-1", "sequence": { "sequence": "MAKNGLVIYILVITLLLDQTSCHASKFKARKHSKRRVKEKDGDLKTQVEKLWREVNALKEMQALQTVCLRGTKFHKKCYLAAEGLKHFHEANEDCISKGGTLVVPRSADEINALRDYGKRSLPGVNDFWLGINDMVAEGKFVDINGLAISFLNWDQAQPNGGKRENCALFSQSAQGKWSDEACHSSKRYICEFTIPQ", "length": 197, "header": "sp|Q28008-1|CLC3A_BOVIN Isoform 1 of C-type lectin domain family 3 member A OS=Bos taurus OX=9913 GN=CLEC3A PE=2 SV=1 CANONICAL=Q28008-1" }, "locus": { "chromosome": "18", "start_pos": 5210470, "end_pos": 5201484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064491.2", "url": "https://www.ensembl.org/id/ENSBTAT00000064491.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000054542.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282415", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282415", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8Q4Q2-1", "protein_name": "C-type lectin domain family 3 member A", "gene_name": "clec3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRQFLLLLLVFCFSFIQDGYGHPSRTKKAVPARQREEDDMKTQIDKLWQEVNSLKEMQALQTVCLRGIKAHRKCYLVSDQAKHYHEANEDCISQGGTLAIPRDVNENEELRDYAKRSSPAARDFWIGITDIVREGQYVDVNSLPVSFFYWDRAKKEPTGGKRESCVALSLSAQGKWHDEVCRSQKKYICEYLIP", "length": 194 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A3L7I0A6-1", "protein_name": "C-type lectin domain family 3 member A", "gene_name": "Clec3a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKNGLVICILVASLLLDQTNSYPSRVKARKHSKRRVKEKDGDLKSQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASEGLKHYHEANEDCISKGGTLVVPRNSDEINVLRDYSKKSLPGVNDFWLGINDMVTEGKFLDVHGFAVSFLNWDRAQPSGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFIIP", "length": 196 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A0E3-1", "protein_name": "C-type lectin domain family 3, member A", "gene_name": "Clec3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVKNRLVICILVASLLLDQISSYPSRAKARKHSKRRVKEKDGDLKSQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASEGLKHYHEANEDCISKGGTLVVPRNSDEINALRDYSKRSLPGVNDFWLGINDMVTEGKFLDVHGFAVSFLNWDRAQPSGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFIIP", "length": 196 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BZI3-1", "protein_name": "C-type lectin domain family 3 member A", "gene_name": "CLEC3A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQTGLMIFLLISILLLDQTISQASKFKAKKHSKRRVKDKDDLKTQIDKLWREVNALKEMQALQSVCLRGTKAHKKCYLISEGTKHFHEANEDCIAKGGTLAIPRNSDEMNTLRDYGKNSVPGGSEFWLGVNDMVNEGKFVDVNGMALQYFNWDRAQPNGGKRENCVFFSTQGKWVDEICRTAKRYICEFLIP", "length": 193 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75596-1", "protein_name": "C-type lectin domain family 3 member A", "gene_name": "CLEC3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRDKDGDLKTQIEKLWTEVNALKEIQALQTVCLRGTKVHKKCYLASEGLKHFHEANEDCISKGGILVIPRNSDEINALQDYGKRSLPGVNDFWLGINDMVTEGKFVDVNGIAISFLNWDRAQPNGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFTIPQ", "length": 197 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EPW4-1", "protein_name": "C-type lectin domain family 3 member A", "gene_name": "Clec3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKNGLVLCILVVSLLLDQTDGYPSRMKARKHSKRRVKAKDDDLKSQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASEGLKHYHEANEDCISKGGTLVVPRNSDEINALRDYGKRSLPGVNDFWLGINDMVTEGKFLDVHGFAVSFLNWDRAQPSGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFIIP", "length": 196 }, "evidence": [ { "id": "Q28008", "url": "https://omabrowser.org/oma/group/Q28008/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "Q28008", "url": "https://www.uniprot.org/uniprotkb/Q28008" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q28008-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q28008-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q28008" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q28008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28008" }, { "id": "PRU00040", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00040" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000255", "start_pos": 74, "end_pos": 192, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q28103-1", "uniprot_ac": "Q28103", "uniprot_id": "MFAP3_BOVIN", "mass": { "chemical_mass": 19317.0, "monoisotopic_mass": 19317.0 }, "refseq": {}, "gene_names": [ { "name": "MFAP3", "type": "recommended", "evidence": [ { "id": "Q28103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28103" } ] } ], "protein_names": [ { "name": "Microfibril-associated glycoprotein 3", "type": "recommended", "evidence": [ { "id": "Q28103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28103/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the elastin-associated microfibrils.", "evidence": [ { "database": "UniProtKB", "id": "Q28103", "url": "https://www.uniprot.org/uniprotkb/Q28103#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q28103", "url": "https://www.uniprot.org/uniprotkb/Q28103" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFAP3", "url": "https://www.uniprot.org/uniprotkb/Q28103", "locus": { "chromosome": "7", "start_pos": 65352532, "end_pos": 65330428, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017079", "url": "https://www.ensembl.org/id/ENSBTAG00000017079" } ] } } ], "crossref": [ { "id": "Q28103", "url": "https://alphafold.ebi.ac.uk/entry/Q28103", "database": "AlphaFoldDB", "categories": [] }, { "id": "Q28103", "url": "https://www.orthodb.org/?gene=Q28103", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14340:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14340:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "Q28103", "url": "https://www.uniprot.org/uniprotkb/Q28103", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q28103-1", "url": "https://www.uniprot.org/uniprotkb/Q28103-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLILNCRAFVEEMFEAVQVDDPDEMGERIKERPALNAQDGIFVINPEMGRSNSPGGDSDDGSLSEQGQEIAVQVSVHPQSETKSIDTDSQDSSHFSPPDDTGSTESNSNYKDGSFESCQL", "length": 175, "header": "sp|Q28103-1|MFAP3_BOVIN Isoform 1 of Microfibril-associated glycoprotein 3 OS=Bos taurus OX=9913 GN=MFAP3 PE=2 SV=1 CANONICAL=Q28103-1" }, "isoforms": [ { "isoform_ac": "Q28103-1", "url": "https://www.uniprot.org/uniprotkb/Q28103/entry#Q28103-1", "sequence": { "sequence": "FRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLILNCRAFVEEMFEAVQVDDPDEMGERIKERPALNAQDGIFVINPEMGRSNSPGGDSDDGSLSEQGQEIAVQVSVHPQSETKSIDTDSQDSSHFSPPDDTGSTESNSNYKDGSFESCQL", "length": 175, "header": "sp|Q28103-1|MFAP3_BOVIN Isoform 1 of Microfibril-associated glycoprotein 3 OS=Bos taurus OX=9913 GN=MFAP3 PE=2 SV=1 CANONICAL=Q28103-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2.", "journal": "Genomics", "date": "1995", "authors": "Abrams WR, Ma RI, Kucich U, Bashir MM, Decker S, Tsipouras P, McPherson JD, Wasmuth JJ, Rosenbloom J", "evidence": [ { "database": "UniProtKB", "id": "Q28103", "url": "https://www.uniprot.org/uniprotkb/Q28103" } ], "reference": [ { "type": "PubMed", "id": "7782085", "url": "https://glygen.org/publication/PubMed/7782085" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q28103", "url": "https://www.uniprot.org/uniprotkb/Q28103" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q28103-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 175, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q28103-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q28103" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q28207-1", "uniprot_ac": "Q28207", "uniprot_id": "IAPP_BOVIN", "mass": { "chemical_mass": 9953.0, "monoisotopic_mass": 9953.0 }, "refseq": { "ac": "NP_001181967", "name": "islet amyloid polypeptide precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" }, "gene_names": [ { "name": "IAPP", "type": "recommended", "evidence": [ { "id": "Q28207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ] }, { "name": "IAPP", "type": "synonym", "evidence": [ { "id": "NP_001181967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" } ] } ], "protein_names": [ { "name": "Islet amyloid polypeptide", "type": "recommended", "evidence": [ { "id": "Q28207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#names_and_taxonomy" } ] }, { "name": "Amylin", "type": "synonym", "evidence": [ { "id": "Q28207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#names_and_taxonomy" } ] }, { "name": "IAPP", "type": "synonym", "evidence": [ { "id": "Q28207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#names_and_taxonomy" } ] }, { "name": "amylin 3-34", "type": "synonym", "evidence": [ { "id": "NP_001181967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" } ] }, { "name": "islet amyloid polypeptide precursor", "type": "synonym", "evidence": [ { "id": "NP_001181967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" } ] } ], "function": [ { "annotation": "Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207#function" }, { "database": "UniProtKB", "id": "P10997", "url": "https://www.uniprot.org/uniprotkb/P10997#function" }, { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprotkb/P12969#function" }, { "database": "UniProtKB", "id": "A0A452DIH0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH0#function" }, { "database": "UniProtKB", "id": "ARBA00049594", "url": "https://www.uniprot.org/uniprotkb/ARBA00049594#function" } ] }, { "annotation": "Bovine amylin differs from the human peptide at 10 positions and is one of the most divergent among known amylin sequences. Bovine amylin oligomerizes but is not toxic to cultured beta-cells and it is considerably less amyloidogenic than the human polypeptide and is only a low-potency agonist at human amylin-responsive receptors.", "evidence": [ { "database": "RefSeq", "id": "NP_001181967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" }, { "database": "PubMed", "id": "30086232", "url": "https://glygen.org/publication/PubMed/30086232" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IAPP", "url": "https://www.uniprot.org/uniprotkb/Q28207", "locus": { "chromosome": "5", "start_pos": 88796314, "end_pos": 88801862, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010530", "url": "https://www.ensembl.org/id/ENSBTAG00000010530" } ] } } ], "crossref": [ { "id": "Q28207", "url": "https://alphafold.ebi.ac.uk/entry/Q28207", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010530", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010530", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138011", "url": "https://www.ncbi.nlm.nih.gov/gene/100138011", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001693", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001693", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138011", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138011", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CATQRLT", "url": "https://omabrowser.org/oma/group/CATQRLT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIH0", "url": "https://www.orthodb.org/?gene=A0A452DIH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q28207", "url": "https://www.orthodb.org/?gene=Q28207", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-419812", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-419812", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001181967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIH0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q28207-1", "url": "https://www.uniprot.org/uniprotkb/Q28207-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGILKLPVVLIVLCVALNHLEGGGKPTESHQMEKRKCGTATCETQRLANFLAPSSNKLGAIFSPTKMGSNTYGKRKKVEILKREPLSYLPI", "length": 91, "header": "sp|Q28207-1|IAPP_BOVIN Isoform 1 of Islet amyloid polypeptide OS=Bos taurus OX=9913 GN=IAPP PE=3 SV=2 CANONICAL=Q28207-1" }, "isoforms": [ { "isoform_ac": "A0A452DIH0-1", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#A0A452DIH0-1", "sequence": { "sequence": "MGILKLPVVLIVLCVALNHLEGGGKPTESHQMEKRKCGTATCETQCLANFLAPSSNKLGAIFSPTKMGSNTYGKRKKVEILKREPLSYLPI", "length": 91, "header": "tr|A0A452DIH0-1|A0A452DIH0_BOVIN Computationally mapped isoform of Islet amyloid polypeptide OS=Bos taurus OX=9913 GN=IAPP PE=3 SV=1 CANONICAL=Q28207-1" }, "locus": { "chromosome": "5", "start_pos": 88801862, "end_pos": 88796459, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013921.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013921.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013921.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013921.5" } ] } }, { "isoform_ac": "A0AAA9TT71-1", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#A0AAA9TT71-1", "sequence": { "sequence": "MGILKLPVVLIVLCVALNHLEGGGKPTERQEWTVSALSRNMLLELKGAEPEHEANPKVIRWKSGNAALPLVRLNAWQIF", "length": 79, "header": "tr|A0AAA9TT71-1|A0AAA9TT71_BOVIN Computationally mapped isoform of Islet amyloid polypeptide OS=Bos taurus OX=9913 GN=IAPP PE=4 SV=1 CANONICAL=Q28207-1" }, "locus": { "chromosome": "5", "start_pos": 88801862, "end_pos": 88796581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112266.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112266.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099725.1" } ] } }, { "isoform_ac": "Q28207-1", "url": "https://www.uniprot.org/uniprotkb/Q28207/entry#Q28207-1", "sequence": { "sequence": "MGILKLPVVLIVLCVALNHLEGGGKPTESHQMEKRKCGTATCETQRLANFLAPSSNKLGAIFSPTKMGSNTYGKRKKVEILKREPLSYLPI", "length": 91, "header": "sp|Q28207-1|IAPP_BOVIN Isoform 1 of Islet amyloid polypeptide OS=Bos taurus OX=9913 GN=IAPP PE=3 SV=2 CANONICAL=Q28207-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Amyloidogenicity, Cytotoxicity, and Receptor Activity of Bovine Amylin: Implications for Xenobiotic Transplantation and the Design of Nontoxic Amylin Variants.", "journal": "ACS chemical biology", "date": "2018-09-21", "authors": "Akter Rehana, Bower Rebekah L, Abedini Andisheh, Schmidt Ann Marie, Hay Debbie L, Raleigh Daniel P", "evidence": [ { "database": "RefSeq", "id": "NP_001181967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181967" } ], "reference": [ { "type": "PubMed", "id": "30086232", "url": "https://glygen.org/publication/PubMed/30086232" } ] } ], "pathway": [ { "id": "bta:100138011", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138011", "resource": "KEGG Pathway" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-419812", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-419812", "resource": "Reactome", "description": "Calcitonin-like ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P10997-1", "protein_name": "Islet amyloid polypeptide", "gene_name": "IAPP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL", "length": 89 }, "evidence": [ { "id": "Q28207", "url": "https://omabrowser.org/oma/group/Q28207/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P12968-1", "protein_name": "Islet amyloid polypeptide", "gene_name": "Iapp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMCISKLPAVLLILSVALNHLRATPVRSGSNPQMDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNAAGDPNRESLDFLLV", "length": 93 }, "evidence": [ { "id": "Q28207", "url": "https://omabrowser.org/oma/group/Q28207/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P12969-1", "protein_name": "Islet amyloid polypeptide", "gene_name": "Iapp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRCISRLPAVLLILSVALGHLRATPVGSGTNPQVDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNVAEDPNRESLDFLLL", "length": 93 }, "evidence": [ { "id": "Q28207", "url": "https://omabrowser.org/oma/group/Q28207/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "amylin receptor signaling pathway", "id": "GO:0097647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097647", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "positive regulation of calcium-mediated signaling", "id": "GO:0050850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050850", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "positive regulation of cAMP/PKA signal transduction", "id": "GO:0141163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141163", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "amylin receptor 3 signaling pathway", "id": "GO:0150061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150061", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "amylin receptor 1 signaling pathway", "id": "GO:0150059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150059", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" }, { "name": "amylin receptor 2 signaling pathway", "id": "GO:0150060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150060", "evidence": [ { "database": "UniProtKB", "id": "Q28207", "url": "https://www.uniprot.org/uniprotkb/Q28207" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q28207-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 91, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q28207-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q28207" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q29RH0-1", "uniprot_ac": "Q29RH0", "uniprot_id": "CST9_BOVIN", "mass": { "chemical_mass": 17950.0, "monoisotopic_mass": 17950.0 }, "refseq": {}, "gene_names": [ { "name": "CST9", "type": "recommended", "evidence": [ { "id": "Q29RH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH0" } ] } ], "protein_names": [ { "name": "Cystatin-9", "type": "recommended", "evidence": [ { "id": "Q29RH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in hematopoietic differentiation or inflammation.", "evidence": [ { "database": "UniProtKB", "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CST9", "url": "https://www.uniprot.org/uniprotkb/Q29RH0", "locus": {} } ], "crossref": [ { "id": "Q29RH0", "url": "https://alphafold.ebi.ac.uk/entry/Q29RH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505033", "url": "https://www.ncbi.nlm.nih.gov/gene/505033", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505033", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505033", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RH0", "url": "https://www.orthodb.org/?gene=Q29RH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46945:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46945:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RH0-1", "url": "https://www.uniprot.org/uniprotkb/Q29RH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRQRRCRWAQPWTLLLLLLGPRLLVTHGWRRKGDKNSENTNILELYLPAVVEYALHVYNMRSQDMNAYKVVRVLRSWLELSEQKEEKGLVFSMELQFARTRCGKFDEDIDNCPFQATPDVNNTITCFFTVDTEPWKTEFQLLNDTCLEGSAE", "length": 153, "header": "sp|Q29RH0-1|CST9_BOVIN Isoform 1 of Cystatin-9 OS=Bos taurus OX=9913 GN=CST9 PE=2 SV=1 CANONICAL=Q29RH0-1" }, "isoforms": [ { "isoform_ac": "Q29RH0-1", "url": "https://www.uniprot.org/uniprotkb/Q29RH0/entry#Q29RH0-1", "sequence": { "sequence": "MGRQRRCRWAQPWTLLLLLLGPRLLVTHGWRRKGDKNSENTNILELYLPAVVEYALHVYNMRSQDMNAYKVVRVLRSWLELSEQKEEKGLVFSMELQFARTRCGKFDEDIDNCPFQATPDVNNTITCFFTVDTEPWKTEFQLLNDTCLEGSAE", "length": 153, "header": "sp|Q29RH0-1|CST9_BOVIN Isoform 1 of Cystatin-9 OS=Bos taurus OX=9913 GN=CST9 PE=2 SV=1 CANONICAL=Q29RH0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 118, "start_aa": "Thr", "end_pos": 118, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr118", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505033", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505033", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "antimicrobial humoral response", "id": "GO:0019730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019730", "evidence": [ { "database": "UniProtKB", "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "Q29RH0", "url": "https://www.uniprot.org/uniprotkb/Q29RH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RH0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RH0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RH0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 118 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 144, "end_pos": 146 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RJ0-1", "uniprot_ac": "Q29RJ0", "uniprot_id": "KCD18_BOVIN", "mass": { "chemical_mass": 46420.0, "monoisotopic_mass": 46420.0 }, "refseq": { "ac": "NP_001039979", "name": "BTB/POZ domain-containing protein KCTD18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039979" }, "gene_names": [ { "name": "KCTD18", "type": "recommended", "evidence": [ { "id": "Q29RJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0" } ] }, { "name": "KCTD18", "type": "synonym", "evidence": [ { "id": "NP_001039979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039979" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD18", "type": "recommended", "evidence": [ { "id": "Q29RJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein KCTD18", "type": "synonym", "evidence": [ { "id": "NP_001039979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039979" } ] }, { "name": "potassium channel tetramerisation domain containing 18", "type": "synonym", "evidence": [ { "id": "NP_001039979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039979" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RJ0", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD18", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0", "locus": { "chromosome": "2", "start_pos": 89035588, "end_pos": 89056404, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002272", "url": "https://www.ensembl.org/id/ENSBTAG00000002272" } ] } } ], "crossref": [ { "id": "Q29RJ0", "url": "https://alphafold.ebi.ac.uk/entry/Q29RJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002272", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002272", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18372", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18372", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613694", "url": "https://www.ncbi.nlm.nih.gov/gene/613694", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613694", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613694", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKAGPKP", "url": "https://omabrowser.org/oma/group/CKAGPKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q29RJ0", "url": "https://www.orthodb.org/?gene=Q29RJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039979", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RJ0", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGHKAEEEVLDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGHLFKYLLDYLHGEVHIPTEEQTRVALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYSTKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSDYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLSHMAPIRKRRLIVNEEEEEGVNCKTGPKPVRFLGPSTSTQIKVKNSASIRVSPASAPQPWPRATANLAAGGRAVQRSAQSKVPTPVGTGLPEHPQAAQGPGAPENGATHLPPAKVLLSDKTATPHRVIKLRRTPLCATGSSLPACTTPRPAGPPEPPPDALSPLGTWTENGQDQTK", "length": 422, "header": "sp|Q29RJ0-1|KCD18_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD18 OS=Bos taurus OX=9913 GN=KCTD18 PE=2 SV=1 CANONICAL=Q29RJ0-1" }, "isoforms": [ { "isoform_ac": "Q29RJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0/entry#Q29RJ0-1", "sequence": { "sequence": "MEGHKAEEEVLDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGHLFKYLLDYLHGEVHIPTEEQTRVALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYSTKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSDYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLSHMAPIRKRRLIVNEEEEEGVNCKTGPKPVRFLGPSTSTQIKVKNSASIRVSPASAPQPWPRATANLAAGGRAVQRSAQSKVPTPVGTGLPEHPQAAQGPGAPENGATHLPPAKVLLSDKTATPHRVIKLRRTPLCATGSSLPACTTPRPAGPPEPPPDALSPLGTWTENGQDQTK", "length": 422, "header": "sp|Q29RJ0-1|KCD18_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD18 OS=Bos taurus OX=9913 GN=KCTD18 PE=2 SV=1 CANONICAL=Q29RJ0-1" }, "locus": { "chromosome": "2", "start_pos": 89053461, "end_pos": 89036753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002929.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002929.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002929.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002929.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613694", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613694", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A425-1", "protein_name": "Potassium channel tetramerization domain containing 18", "gene_name": "KCTD18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEDKAAEEQGILRLNVRGCLYTARRQSLCRFKDSMLASMFSGRFPLKMDESGACLIDRDGSLFKYLLDYLHGEVRIPEDKQIRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNVELKKALLDFCDSYDLVCTKPTVWVLHYLSTSGASCESKIIGVYATRADGTDAINKELGTKIHSKSIYKREAGNNVQYIWSYYSEAELKKMMDAFGTWEGRGVSYWRVPQELIECWTLEERSLKGSLHHMPPVHKRRLIDFSEVEDYIPCKVGPKPIRFSGPSTSTHIKVKNSASLKVAACNTSHSAVTLKRPNSESLILHKAASKTVSTACVPEPSNSQVPHGKQSADDKASCQMTFNISVSRKPVSSRAVKLKRTPLFLVTPSQSSSVSSKTSEQDKAAAEIPTTSMVLNKKEPAMLAESIKLKSNKVDG", "length": 430 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FB93-1", "protein_name": "BTB/POZ domain-containing protein KCTD18", "gene_name": "Kctd18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKLQESKGRMADHRAEDLLDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACIIDRDGQLFKYILDYLHGEVQIPSDEQTRTALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLICNKPTVWVLHYLNTSGASCESRIIGVYATKADGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLHGSLRHMTPIRKRRLLTLSEEDEGVNCKAGPKPVRFLGPSTSTQIKVKNSAAVRVSPVSAAQITSQATANRSQRGSYGKAAQCPVATGASGHAPASPQAQSAENQATQPPPAKVLLSDKKSPSNRVIKLRRTPLCVGTSLPTPSAGSQAGSPQQPSPEASITSGVRTETREDQPDG", "length": 427 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A827-1", "protein_name": "Potassium channel tetramerization domain containing 18", "gene_name": "Kctd18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGHEAEEMRDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACIIDRDGHLFKYILDYLHGEVQTPSDEQTRTALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYSTKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLHGSLRHMAPIRKRRLIAFGEEDEGVNCKTGPKPVRFLGPSTSTQIKVKNSASVRVSPANAAQISSQATANRSQRGSCGKAAQCSVATGASGHAPASPNAQSAENQATQPPPAKVLLSDKKSPPHRVIKLRRTPLCVGPSLPTPSAGSQASFPQQPSPEASNTLGVQTENRKDQPDG", "length": 417 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E0CZ26-1", "protein_name": "Potassium channel tetramerisation domain containing 18", "gene_name": "Kctd18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLKAELQASKGAMAGHEAEDVLDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACIINRDGHLFKYILDYLHGEVQTPSDEQTRAALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLHGSLRHMAPIRKRRLIALREEDEGVNCKTGPKPVRFLGPSTSTQIKVKNSASVRVSPANAAQISSQATANRSHRGSCGKAAQCSVATGASGHAPASPDAQSSENQATHPPPAKVLLSEKKSPPPRVIKLRRTPLRGGPSLPTASAGGQACFPQPPSLEASSSLGVQMETRKDQPDG", "length": 429 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1SI68-1", "protein_name": "Potassium channel tetramerization domain containing 18", "gene_name": "KCTD18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESHKAEEEVVDILRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGHLFKYLLDYLHGEVHIPTEEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYSTKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLHHMAPIRKRRLTAFNEEEEEGENCKTGPKPVRFLGPSTSTQIKVKNSASVRVSPARASVNTAAGGKAAQRCAPTRVPSLVGTAGAENGAGHPPPAKVLLSDKKATPPRVIKLKRTPLCATGPSPPACPAARTVGTPEPPPNAPGALDLWTENGQRQTD", "length": 404 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PI47-1", "protein_name": "BTB/POZ domain-containing protein KCTD18", "gene_name": "KCTD18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGEVQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIEKQLGGRIHSKGIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEADESVNYKTGPKPVRFLGPSTSTQIKVKNSASVTVSPASAIQTSAGATANRFQSGSRRKAAQRSAPSRATALVGTGAPGHPQASPGAASAENGGTHLPPAKVLLSDKKPTPQRVIKLKRTPLCATAPCLPSPTATRQANSLKPLPGEAARALGVRTENGKNKGN", "length": 426 }, "evidence": [ { "id": "Q29RJ0", "url": "https://omabrowser.org/oma/group/Q29RJ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q29RJ0", "url": "https://www.uniprot.org/uniprotkb/Q29RJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RJ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 422, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RJ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RJ0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RM3-1", "uniprot_ac": "Q29RM3", "uniprot_id": "REEP5_BOVIN", "mass": { "chemical_mass": 21417.0, "monoisotopic_mass": 21417.0 }, "refseq": { "ac": "NP_001040070", "name": "receptor expression-enhancing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040070" }, "gene_names": [ { "name": "REEP5", "type": "recommended", "evidence": [ { "id": "Q29RM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM3" } ] }, { "name": "REEP5", "type": "synonym", "evidence": [ { "id": "NP_001040070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040070" } ] } ], "protein_names": [ { "name": "Receptor expression-enhancing protein 5", "type": "recommended", "evidence": [ { "id": "Q29RM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM3/entry#names_and_taxonomy" } ] }, { "name": "receptor expression-enhancing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001040070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040070" } ] } ], "function": [ { "annotation": "Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.", "evidence": [ { "database": "UniProtKB", "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3#function" }, { "database": "UniProtKB", "id": "Q60870", "url": "https://www.uniprot.org/uniprotkb/Q60870#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REEP5", "url": "https://www.uniprot.org/uniprotkb/Q29RM3", "locus": { "chromosome": "10", "start_pos": 1145330, "end_pos": 1094713, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012804", "url": "https://www.ensembl.org/id/ENSBTAG00000012804" } ] } } ], "crossref": [ { "id": "Q29RM3", "url": "https://alphafold.ebi.ac.uk/entry/Q29RM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "617543", "url": "https://www.ncbi.nlm.nih.gov/gene/617543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617543", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617543", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RM3", "url": "https://www.orthodb.org/?gene=Q29RM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RM3-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKTEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEARKAAVSLLGEEKKST", "length": 189, "header": "sp|Q29RM3-1|REEP5_BOVIN Isoform 1 of Receptor expression-enhancing protein 5 OS=Bos taurus OX=9913 GN=REEP5 PE=2 SV=1 CANONICAL=Q29RM3-1" }, "isoforms": [ { "isoform_ac": "Q29RM3-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM3/entry#Q29RM3-1", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKTEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEARKAAVSLLGEEKKST", "length": 189, "header": "sp|Q29RM3-1|REEP5_BOVIN Isoform 1 of Receptor expression-enhancing protein 5 OS=Bos taurus OX=9913 GN=REEP5 PE=2 SV=1 CANONICAL=Q29RM3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617543", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617543", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane organization", "id": "GO:0090158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090158", "evidence": [ { "database": "UniProtKB", "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sarcoplasmic reticulum membrane", "id": "GO:0033017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033017", "evidence": [ { "database": "UniProtKB", "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "Q29RM3", "url": "https://www.uniprot.org/uniprotkb/Q29RM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 189, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RM3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RM6-1", "uniprot_ac": "Q29RM6", "uniprot_id": "NRAC_BOVIN", "mass": { "chemical_mass": 17514.0, "monoisotopic_mass": 17514.0 }, "refseq": { "ac": "NP_001192317", "name": "nutritionally-regulated adipose and cardiac-enriched protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317" }, "gene_names": [ { "name": "NRAC", "type": "recommended", "evidence": [ { "id": "Q29RM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM6" } ] }, { "name": "C21H14orf180", "type": "synonym", "evidence": [ { "id": "NP_001192317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317" } ] }, { "name": "NRAC", "type": "synonym", "evidence": [ { "id": "NP_001192317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317" } ] } ], "protein_names": [ { "name": "Nutritionally-regulated adipose and cardiac-enriched protein homolog", "type": "recommended", "evidence": [ { "id": "Q29RM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM6/entry#names_and_taxonomy" } ] }, { "name": "nutritionally-regulated adipose and cardiac-enriched protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001192317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317" } ] }, { "name": "transmembrane protein C14orf180 homolog", "type": "synonym", "evidence": [ { "id": "NP_001192317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RM6", "url": "https://www.uniprot.org/uniprotkb/Q29RM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRAC", "url": "https://www.uniprot.org/uniprotkb/Q29RM6", "locus": {} } ], "crossref": [ { "id": "Q29RM6", "url": "https://alphafold.ebi.ac.uk/entry/Q29RM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "615365", "url": "https://www.ncbi.nlm.nih.gov/gene/615365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RM6", "url": "https://www.orthodb.org/?gene=Q29RM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36868", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36868", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36868:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36868:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15555", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15555", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192317", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RM6", "url": "https://www.uniprot.org/uniprotkb/Q29RM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RM6-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RM6-2", "url": "https://www.uniprot.org/uniprotkb/Q29RM6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTAVHALSPDSRPETQHQTRKNEEAAPGSPTPRAGREGRKGPASILRRSPQERCGRGDEPRRTTRHVRFREPLEVAVHYIACREPTTAVQAPSRPRPRGGSLLLRLTACILLALALGMCCGQAGPMARALEDFRARLLAALLRLPLAALDCWRCLLQL", "length": 159, "header": "sp|Q29RM6-1|NRAC_BOVIN Isoform 1 of Nutritionally-regulated adipose and cardiac-enriched protein homolog OS=Bos taurus OX=9913 GN=NRAC PE=2 SV=2 CANONICAL=Q29RM6-1" }, "isoforms": [ { "isoform_ac": "Q29RM6-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM6/entry#Q29RM6-1", "sequence": { "sequence": "MKTAVHALSPDSRPETQHQTRKNEEAAPGSPTPRAGREGRKGPASILRRSPQERCGRGDEPRRTTRHVRFREPLEVAVHYIACREPTTAVQAPSRPRPRGGSLLLRLTACILLALALGMCCGQAGPMARALEDFRARLLAALLRLPLAALDCWRCLLQL", "length": 159, "header": "sp|Q29RM6-1|NRAC_BOVIN Isoform 1 of Nutritionally-regulated adipose and cardiac-enriched protein homolog OS=Bos taurus OX=9913 GN=NRAC PE=2 SV=2 CANONICAL=Q29RM6-1" }, "locus": {} }, { "isoform_ac": "Q29RM6-2", "url": "https://www.uniprot.org/uniprotkb/Q29RM6/entry#Q29RM6-2", "sequence": { "sequence": "MKTAVHALSPDSRPETQHQTRKNEEAAPGSPTPRAGREGRKGPASILRRSPQERCGRGDEPRRTTRHVRFREPLEVAVH", "length": 79, "header": "sp|Q29RM6-2|NRAC_BOVIN Isoform 2 of Nutritionally-regulated adipose and cardiac-enriched protein homolog OS=Bos taurus OX=9913 GN=NRAC PE=2 SV=2 CANONICAL=Q29RM6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 32, "start_aa": "Thr", "end_pos": 32, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr32", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615365", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q29RM6", "url": "https://www.uniprot.org/uniprotkb/Q29RM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RM6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RM6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RM6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 32 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RM9-1", "uniprot_ac": "Q29RM9", "uniprot_id": "RGS4_BOVIN", "mass": { "chemical_mass": 23328.0, "monoisotopic_mass": 23328.0 }, "refseq": { "ac": "NP_001040065", "name": "regulator of G-protein signaling 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040065" }, "gene_names": [ { "name": "RGS4", "type": "recommended", "evidence": [ { "id": "Q29RM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" } ] }, { "name": "RGS4", "type": "synonym", "evidence": [ { "id": "NP_001040065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040065" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling 4", "type": "recommended", "evidence": [ { "id": "Q29RM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM9/entry#names_and_taxonomy" } ] }, { "name": "RGS4", "type": "synonym", "evidence": [ { "id": "Q29RM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM9/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling 4", "type": "synonym", "evidence": [ { "id": "NP_001040065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040065" } ] }, { "name": "regulator of G-protein signalling 4", "type": "synonym", "evidence": [ { "id": "NP_001040065", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040065" } ] } ], "function": [ { "annotation": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G protein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS4", "url": "https://www.uniprot.org/uniprotkb/Q29RM9", "locus": { "chromosome": "3", "start_pos": 6291077, "end_pos": 6298331, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046277", "url": "https://www.ensembl.org/id/ENSBTAG00000046277" } ] } } ], "crossref": [ { "id": "Q29RM9", "url": "https://alphafold.ebi.ac.uk/entry/Q29RM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046277", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046277", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617437", "url": "https://www.ncbi.nlm.nih.gov/gene/617437", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617437", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617437", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LIQDLCQ", "url": "https://omabrowser.org/oma/group/LIQDLCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q29RM9", "url": "https://www.orthodb.org/?gene=Q29RM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040065", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RM9-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA", "length": 205, "header": "sp|Q29RM9-1|RGS4_BOVIN Isoform 1 of Regulator of G protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=2 SV=1 CANONICAL=Q29RM9-1" }, "isoforms": [ { "isoform_ac": "Q29RM9-1", "url": "https://www.uniprot.org/uniprotkb/Q29RM9/entry#Q29RM9-1", "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA", "length": 205, "header": "sp|Q29RM9-1|RGS4_BOVIN Isoform 1 of Regulator of G protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=2 SV=1 CANONICAL=Q29RM9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617437", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617437", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "P49798-1", "protein_name": "Regulator of G protein signaling 4", "gene_name": "RGS4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA", "length": 205 }, "evidence": [ { "id": "Q29RM9", "url": "https://omabrowser.org/oma/group/Q29RM9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49799-1", "protein_name": "Regulator of G protein signaling 4", "gene_name": "Rgs4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQRVSQEEVKKWAESLENLINHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVPQCA", "length": 205 }, "evidence": [ { "id": "Q29RM9", "url": "https://omabrowser.org/oma/group/Q29RM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of G protein-coupled receptor signaling pathway", "id": "GO:0045744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045744", "evidence": [ { "database": "UniProtKB", "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "Q29RM9", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RM9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q29RM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RM9" }, { "id": "PRU00171", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000255", "start_pos": 62, "end_pos": 178, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 36, "end_pos": 38 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RR1-1", "uniprot_ac": "Q29RR1", "uniprot_id": "LRC41_BOVIN", "mass": { "chemical_mass": 88677.0, "monoisotopic_mass": 88677.0 }, "refseq": { "ac": "NP_001039338", "name": "leucine-rich repeat-containing protein 41", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039338" }, "gene_names": [ { "name": "LRRC41", "type": "recommended", "evidence": [ { "id": "Q29RR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ] }, { "name": "LRRC41", "type": "synonym", "evidence": [ { "id": "NP_001039338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039338" } ] }, { "name": "MUF1", "type": "synonym", "evidence": [ { "id": "NP_001039338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039338" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 41", "type": "recommended", "evidence": [ { "id": "Q29RR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR1/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 41", "type": "synonym", "evidence": [ { "id": "NP_001039338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039338" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC41", "url": "https://www.uniprot.org/uniprotkb/Q29RR1", "locus": { "chromosome": "3", "start_pos": 99817768, "end_pos": 99799405, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045664", "url": "https://www.ensembl.org/id/ENSBTAG00000045664" } ] } } ], "crossref": [ { "id": "Q29RR1", "url": "https://alphafold.ebi.ac.uk/entry/Q29RR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "337889", "url": "https://www.ncbi.nlm.nih.gov/gene/337889", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:337889", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RR1", "url": "https://www.orthodb.org/?gene=Q29RR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15354", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15354", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15354:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15354:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001039338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039338", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RR1-1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQTARAAPATRVTRRSTQESLTAGGTDSKREPLPPATSHEAPGTKRPPSAPATTSSASASSSTSSSKRAPASSAPQPKPLKRFKRAAGKKGARTRQGCGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSVQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPGNAGPPSNVIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLTLKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM", "length": 814, "header": "sp|Q29RR1-1|LRC41_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 41 OS=Bos taurus OX=9913 GN=LRRC41 PE=2 SV=1 CANONICAL=Q29RR1-1" }, "isoforms": [ { "isoform_ac": "Q29RR1-1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1/entry#Q29RR1-1", "sequence": { "sequence": "MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQTARAAPATRVTRRSTQESLTAGGTDSKREPLPPATSHEAPGTKRPPSAPATTSSASASSSTSSSKRAPASSAPQPKPLKRFKRAAGKKGARTRQGCGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSVQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPGNAGPPSNVIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLTLKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM", "length": 814, "header": "sp|Q29RR1-1|LRC41_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 41 OS=Bos taurus OX=9913 GN=LRRC41 PE=2 SV=1 CANONICAL=Q29RR1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 155, "end_pos": 155, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "site_lbl": "Ser155" }, { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "site_lbl": "Ser276" }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "site_lbl": "Ser326" }, { "start_pos": 327, "end_pos": 327, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "site_lbl": "Thr327" }, { "start_pos": 375, "end_pos": 375, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "site_lbl": "Ser375" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:337889", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337889", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q29RR1", "url": "https://www.uniprot.org/uniprotkb/Q29RR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" }, { "start_pos": 703, "end_pos": 705, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RR1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 155, 276, 326, 327, 375 ], "sequon_annotation_sites": [ { "start_pos": 645, "end_pos": 647 }, { "start_pos": 671, "end_pos": 673 }, { "start_pos": 703, "end_pos": 705 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RU2-1", "uniprot_ac": "Q29RU2", "uniprot_id": "OIT3_BOVIN", "mass": { "chemical_mass": 60550.0, "monoisotopic_mass": 60550.0 }, "refseq": { "ac": "NP_001039529", "name": "oncoprotein-induced transcript 3 protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039529" }, "gene_names": [ { "name": "OIT3", "type": "recommended", "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ] }, { "name": "OIT3", "type": "synonym", "evidence": [ { "id": "NP_001039529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039529" } ] } ], "protein_names": [ { "name": "Oncoprotein-induced transcript 3 protein", "type": "recommended", "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2/entry#names_and_taxonomy" } ] }, { "name": "oncoprotein-induced transcript 3 protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001039529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039529" } ] }, { "name": "oncoprotein-induced transcript 3 protein", "type": "synonym", "evidence": [ { "id": "NP_001039529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039529" } ] } ], "function": [ { "annotation": "May be involved in hepatocellular function and development.", "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OIT3", "url": "https://www.uniprot.org/uniprotkb/Q29RU2", "locus": { "chromosome": "28", "start_pos": 28942806, "end_pos": 28915275, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009348", "url": "https://www.ensembl.org/id/ENSBTAG00000009348" } ] } } ], "crossref": [ { "id": "Q29RU2", "url": "https://alphafold.ebi.ac.uk/entry/Q29RU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510915", "url": "https://www.ncbi.nlm.nih.gov/gene/510915", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510915", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RU2", "url": "https://www.orthodb.org/?gene=Q29RU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23283", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23283", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RU2-1", "url": "https://www.uniprot.org/uniprotkb/Q29RU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYQCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGPISIDWED", "length": 547, "header": "sp|Q29RU2-1|OIT3_BOVIN Isoform 1 of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=2 SV=1 CANONICAL=Q29RU2-1" }, "isoforms": [ { "isoform_ac": "Q29RU2-1", "url": "https://www.uniprot.org/uniprotkb/Q29RU2/entry#Q29RU2-1", "sequence": { "sequence": "MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYQCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGPISIDWED", "length": 547, "header": "sp|Q29RU2-1|OIT3_BOVIN Isoform 1 of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=2 SV=1 CANONICAL=Q29RU2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 116, "start_aa": "Asn", "end_pos": 116, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn116", "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 299, "start_aa": "Asn", "end_pos": 299, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn299", "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 89, "start_aa": "Asn", "end_pos": 89, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn89", "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510915", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510915", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q29RU2", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RU2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 547, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RU2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RU2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" }, { "id": "PRU01408", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01408" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "D10C", "eco_id": "ECO_0000255", "start_pos": 23, "end_pos": 149, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "Asn89,Asn116" }, { "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like; calcium-binding", "eco_id": "ECO_0000255", "start_pos": 182, "end_pos": 222, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q29RU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU2" }, { "id": "PRU00375", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00375" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZP", "eco_id": "ECO_0000255", "start_pos": 267, "end_pos": 516, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "Asn299" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 89, 116, 299 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RZ5-1", "uniprot_ac": "Q29RZ5", "uniprot_id": "TNG2_BOVIN", "mass": { "chemical_mass": 30829.0, "monoisotopic_mass": 30829.0 }, "refseq": { "ac": "NP_001030405", "name": "transport and Golgi organization protein 2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" }, "gene_names": [ { "name": "TANGO2", "type": "recommended", "evidence": [ { "id": "Q29RZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ] }, { "name": "C17H22orf25", "type": "synonym", "evidence": [ { "id": "NP_001030405", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" } ] }, { "name": "C22orf25", "type": "synonym", "evidence": [ { "id": "NP_001030405", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" } ] }, { "name": "TANGO2", "type": "synonym", "evidence": [ { "id": "NP_001030405", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" } ] } ], "protein_names": [ { "name": "Transport and Golgi organization protein 2 homolog", "type": "recommended", "evidence": [ { "id": "Q29RZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5/entry#names_and_taxonomy" } ] }, { "name": "transport and Golgi organization protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030405", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" } ] }, { "name": "uncharacterized protein C22orf25 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030405", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405" } ] } ], "function": [ { "annotation": "May be involved in lipid homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5#function" }, { "database": "UniProtKB", "id": "Q6ICL3", "url": "https://www.uniprot.org/uniprotkb/Q6ICL3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TANGO2", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5", "locus": { "chromosome": "17", "start_pos": 72967475, "end_pos": 72934812, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012421", "url": "https://www.ensembl.org/id/ENSBTAG00000012421" } ] } } ], "crossref": [ { "id": "Q29RZ5", "url": "https://alphafold.ebi.ac.uk/entry/Q29RZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "518209", "url": "https://www.ncbi.nlm.nih.gov/gene/518209", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518209", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518209", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29RZ5", "url": "https://www.orthodb.org/?gene=Q29RZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17985:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17985:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030405", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGEREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 276, "header": "sp|Q29RZ5-1|TNG2_BOVIN Isoform 1 of Transport and Golgi organization protein 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=2 SV=1 CANONICAL=Q29RZ5-1" }, "isoforms": [ { "isoform_ac": "Q29RZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5/entry#Q29RZ5-1", "sequence": { "sequence": "MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGEREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 276, "header": "sp|Q29RZ5-1|TNG2_BOVIN Isoform 1 of Transport and Golgi organization protein 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=2 SV=1 CANONICAL=Q29RZ5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518209", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518209", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ5", "url": "https://www.uniprot.org/uniprotkb/Q29RZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 276, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RZ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29RZ9-1", "uniprot_ac": "Q29RZ9", "uniprot_id": "DAA10_BOVIN", "mass": { "chemical_mass": 39818.0, "monoisotopic_mass": 39818.0 }, "refseq": { "ac": "NP_001039930", "name": "dynein axonemal assembly factor 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" }, "gene_names": [ { "name": "DNAAF10", "type": "recommended", "evidence": [ { "id": "Q29RZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ] }, { "name": "DNAAF10", "type": "synonym", "evidence": [ { "id": "NP_001039930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" } ] }, { "name": "WDR92", "type": "synonym", "evidence": [ { "id": "NP_001039930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" }, { "id": "Q29RZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ] } ], "protein_names": [ { "name": "Dynein axonemal assembly factor 10", "type": "recommended", "evidence": [ { "id": "Q29RZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9/entry#names_and_taxonomy" } ] }, { "name": "WD repeat domain 92", "type": "synonym", "evidence": [ { "id": "NP_001039930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" } ] }, { "name": "WD repeat-containing protein 92", "type": "synonym", "evidence": [ { "id": "NP_001039930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" }, { "id": "Q29RZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9/entry#names_and_taxonomy" } ] }, { "name": "dynein axonemal assembly factor 10", "type": "synonym", "evidence": [ { "id": "NP_001039930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930" } ] } ], "function": [ { "annotation": "Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9#function" }, { "database": "UniProtKB", "id": "A8J3F6", "url": "https://www.uniprot.org/uniprotkb/A8J3F6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAAF10", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9", "locus": { "chromosome": "11", "start_pos": 66560111, "end_pos": 66589114, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010595", "url": "https://www.ensembl.org/id/ENSBTAG00000010595" } ] } } ], "crossref": [ { "id": "Q29RZ9", "url": "https://alphafold.ebi.ac.uk/entry/Q29RZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540032", "url": "https://www.ncbi.nlm.nih.gov/gene/540032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540032", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540032", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLWKYNY", "url": "https://omabrowser.org/oma/group/CLWKYNY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q29RZ9", "url": "https://www.orthodb.org/?gene=Q29RZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10971", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10971", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29RZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAFEKPQIISHIQKSLSYTVFDCKWMPCSAKFVTMGNFARGTGVIQLYEIQQGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFAGNLHIWNLEAPEVPVYSVKGHKEIINTIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNREVFLTAGGAGSLHLWKYEYPIQRSKKDSEGVEMGVAGSVSLLQNVTLSTQPVSSLDWSPDKRGLCICSSFDQMVRVLIVTKLHKI", "length": 357, "header": "sp|Q29RZ9-1|DAA10_BOVIN Isoform 1 of Dynein axonemal assembly factor 10 OS=Bos taurus OX=9913 GN=DNAAF10 PE=2 SV=1 CANONICAL=Q29RZ9-1" }, "isoforms": [ { "isoform_ac": "Q29RZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9/entry#Q29RZ9-1", "sequence": { "sequence": "MSAFEKPQIISHIQKSLSYTVFDCKWMPCSAKFVTMGNFARGTGVIQLYEIQQGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFAGNLHIWNLEAPEVPVYSVKGHKEIINTIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNREVFLTAGGAGSLHLWKYEYPIQRSKKDSEGVEMGVAGSVSLLQNVTLSTQPVSSLDWSPDKRGLCICSSFDQMVRVLIVTKLHKI", "length": 357, "header": "sp|Q29RZ9-1|DAA10_BOVIN Isoform 1 of Dynein axonemal assembly factor 10 OS=Bos taurus OX=9913 GN=DNAAF10 PE=2 SV=1 CANONICAL=Q29RZ9-1" }, "locus": { "chromosome": "11", "start_pos": 66589070, "end_pos": 66560847, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014007.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014007.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014007.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014007.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540032", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540032", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YWG7-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "DNAAF10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAAGLERPQVVVHAQQSLNYTVFDCKWVPRSARLLCLGSAPRGTGVLQLYELRGGRLLLLSEIEKAKPIKCATFGAASLQQRHLATGDFAGSLSIWNLEAPEIPVYSVKGHKEIINSIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKETPVANMEPAQGESKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRTMSLRWETNIKNGVCSVEFDRKDVNMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTIWQVRHLPQNRDVFMTSGGAGSLHLWKYEYPAQRSKKDSEGAEMGVAGSVSLLQNVTLSTQPISSLDWSPDKKGLCVCGAFDQTVRVLIVTKLNKV", "length": 359 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SJ04-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "DNAAF10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAFEKPQIIAHIQKSLNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFAGNLHIWNLEAPDIPVYSVKAHKEIINTIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGVEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCLCSSFDQMVRVLIVTKLHKI", "length": 357 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HEG2-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "Wdr92", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSAFEKPQIIVHIQKGLNYTVFDCKWVPCSAKFVTMGNFARGTGVIQVYEIQRGDLKLLREIEKAKPIKCGTFGAASLQQRYLATGDFDGNLHIWNLEAPEMPVYSVKGHKEIINTIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPAQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVTEKAHKSTIWQVRHLPQNRELFLTAGGAGSLHLWKYEYPTHRSKKDSEGIQMGVAGSVSLLQNVTLSTQPVSSLDWSPDKRGLCICSSFDQTVRVLIVTKLQTI", "length": 357 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54E33-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "dnaaf10", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSALGESNNKQNGKEILHNYVTKKLTSQPYSCQWIPTSCSVVTVGKKTSGGISKGDIKIHQLEFDDTSGDPKLNLVYENEFTNPFRCLSFFKQANQLQQQDNRKFITGDFNGQISEWDSDICDIPIWGVKGAHQGSISAIDAYADNLVVCGGKDGTIKVYDTRIKPNSANDNNGNNSSPISTFEQTNKSNCWSICTNDNNIIAGFENGDLNIYNLKTNSIQSTTKLNGGICSIDSNDRSNILNQFLITTNKSFISIASFNNNNNNNIEFKDYDINKEPNQTIWSGIYSPWNKKDNENIFTIAQGDGSVSMYRDDCKLIDKVLVSDLPILSLDYSKDRKGLLCCISLKKQLSILISPC", "length": 357 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q561Y0-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "dnaaf10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAALEKPQIIAHIQKSLNYTVFESKWIPCSAKFVCMGNFARGTGVMQIYEIQHGELQLVREIEKSKPIKCGTFGATSLQQRHLATGDFDGNLNVWNLEVPDSPVYSVKAHKEIINAIDGVGGLGIGDGAPEIVTGSRDGTVKVWDSRQKDTPVVNMEPTEGETKRDCWTVAFGHAFNDQDRCVCAGYDNGDIKLFDLRNMSLRWEKNIRNGVCSVEFDRKDINMNKLVATSLEGKFHVFDMRTQHPSKGFASVSEKAHKSTIWQVRHLPQNRDVFMTAGGAGNLHLWKYEYPAQRSKKGADDVEMGVAGSVNLLQNVTLSTQPISSLDWSPDKQGLCVCSSFDQSVRVLIVTKLNTV", "length": 358 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BGF3-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "Dnaaf10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTFEKPQIIVHIQKGLNYTVFDSKWVPCSAKFVTMGNFARGTGVIQVYEIQRGDLKLLREIEKAKPIKCGTFGAASLQQRFLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINTIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKEDPVANMEPAQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVTEKAHKSTVWQVRHLPQNREIFLTTGGAGSLHLWKYEYPTQRSKKDSEGLEMGVAGSVSLLQNVTVSTQPISSLDWSPDKRGLCVCSSFDQMVRVLIVTKLQTI", "length": 357 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96MX6-1", "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "DNAAF10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNKI", "length": 357 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VVM7-1", "protein_name": "WD repeat domain 92", "gene_name": "Wdr92", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDKPQLIEHLHEALNYTVYDTKWVPLSAKFVILGSKANGHGIMDIYELNQDKLVKVKSVEKKVAFKCGTFGAASLRNRHMAIGDFEGRLQVLDMEQPDLPVYNVKAHNGIINTIDAIGGTQIDCGAPEIVTGSRDGAVKVWDIRQGQAPVVDMSPPPQMGDGVNNSSGRRDCWAVAFGNTYNAEERIVAAGYDNGDLKIFDLRSLSVRWEATMKNGICGLEFDRRDIPMNKLAVTTLEGGLLVFDMRTQHPTKGFSYVEERNAGRSVGTNGVISGPKATVWVVRHLPQNRDLFLTGGGTGSIRLWQYEYPDRRVIDDSDGNKLGVAGALNMLSAATLSSQPVHCFDWHPDKLGLAVCGAFDQSVRVLITTKLNTF", "length": 375 }, "evidence": [ { "id": "Q29RZ9", "url": "https://omabrowser.org/oma/group/Q29RZ9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ], "pmid": "" }, { "name": "axonemal dynein complex assembly", "id": "GO:0070286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070286", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "Q29RZ9", "url": "https://www.uniprot.org/uniprotkb/Q29RZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29RZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29RZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29RZ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 316, "end_pos": 318 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29S14-1", "uniprot_ac": "Q29S14", "uniprot_id": "TV23B_BOVIN", "mass": { "chemical_mass": 23667.0, "monoisotopic_mass": 23667.0 }, "refseq": { "ac": "NP_001039617", "name": "Golgi apparatus membrane protein TVP23 homolog B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" }, "gene_names": [ { "name": "TVP23B", "type": "recommended", "evidence": [ { "id": "Q29S14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ] }, { "name": "FAM18B1", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" }, { "id": "Q29S14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ] }, { "name": "FAM18B2", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "FAM18B", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" }, { "id": "Q29S14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ] }, { "name": "TVP23B", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "TVP23C", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] } ], "protein_names": [ { "name": "Golgi apparatus membrane protein TVP23 homolog B", "type": "recommended", "evidence": [ { "id": "Q29S14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S14/entry#names_and_taxonomy" } ] }, { "name": "Golgi apparatus membrane protein TVP23 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "family with sequence similarity 18, member B2", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "family with sequence similarity 18, member B", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "protein FAM18B1", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] }, { "name": "trans-golgi network vesicle protein 23 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001039617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29S14", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TVP23B", "url": "https://www.uniprot.org/uniprotkb/Q29S14", "locus": {} } ], "crossref": [ { "id": "Q29S14", "url": "https://alphafold.ebi.ac.uk/entry/Q29S14", "database": "AlphaFoldDB", "categories": [] }, { "id": "513550", "url": "https://www.ncbi.nlm.nih.gov/gene/513550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513550", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513550", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q29S14", "url": "https://www.orthodb.org/?gene=Q29S14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13019:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13019:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039617", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29S14", "url": "https://www.uniprot.org/uniprotkb/Q29S14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29S14-1", "url": "https://www.uniprot.org/uniprotkb/Q29S14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQQDSNDDTEDVSLFDAEEETTNRPKKSRIRHPVASFFHLFFRVSAIIVYLLCELFSSSFIACMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKASPQEGKTVSEAESRIFWLGLVACPVLWVVFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVGSRKNLTSMATTYLGRQFLRQTTGDTQTSSGE", "length": 208, "header": "sp|Q29S14-1|TV23B_BOVIN Isoform 1 of Golgi apparatus membrane protein TVP23 homolog B OS=Bos taurus OX=9913 GN=TVP23B PE=2 SV=1 CANONICAL=Q29S14-1" }, "isoforms": [ { "isoform_ac": "Q29S14-1", "url": "https://www.uniprot.org/uniprotkb/Q29S14/entry#Q29S14-1", "sequence": { "sequence": "MLQQDSNDDTEDVSLFDAEEETTNRPKKSRIRHPVASFFHLFFRVSAIIVYLLCELFSSSFIACMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKASPQEGKTVSEAESRIFWLGLVACPVLWVVFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVGSRKNLTSMATTYLGRQFLRQTTGDTQTSSGE", "length": 208, "header": "sp|Q29S14-1|TV23B_BOVIN Isoform 1 of Golgi apparatus membrane protein TVP23 homolog B OS=Bos taurus OX=9913 GN=TVP23B PE=2 SV=1 CANONICAL=Q29S14-1" }, "locus": { "chromosome": "19", "start_pos": 32993383, "end_pos": 32985071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120542.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120542.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094179.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513550", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513550", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q29S14", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q29S14", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q29S14", "url": "https://www.uniprot.org/uniprotkb/Q29S14" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29S14-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29S14-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29S14" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q29S17-1", "uniprot_ac": "Q29S17", "uniprot_id": "SNPC5_BOVIN", "mass": { "chemical_mass": 11348.0, "monoisotopic_mass": 11348.0 }, "refseq": { "ac": "NP_001040038", "name": "snRNA-activating protein complex subunit 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038" }, "gene_names": [ { "name": "SNAPC5", "type": "recommended", "evidence": [ { "id": "Q29S17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ] }, { "name": "SNAPC5", "type": "synonym", "evidence": [ { "id": "NP_001040038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038" } ] } ], "protein_names": [ { "name": "snRNA-activating protein complex subunit 5", "type": "recommended", "evidence": [ { "id": "Q29S17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S17/entry#names_and_taxonomy" } ] }, { "name": "SNAPc subunit 5", "type": "synonym", "evidence": [ { "id": "NP_001040038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038" }, { "id": "Q29S17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S17/entry#names_and_taxonomy" } ] }, { "name": "Small nuclear RNA-activating complex polypeptide 5", "type": "synonym", "evidence": [ { "id": "Q29S17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S17/entry#names_and_taxonomy" } ] }, { "name": "small nuclear RNA activating complex, polypeptide 5, 19kDa", "type": "synonym", "evidence": [ { "id": "NP_001040038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038" } ] }, { "name": "snRNA-activating protein complex subunit 5", "type": "synonym", "evidence": [ { "id": "NP_001040038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038" } ] } ], "function": [ { "annotation": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAPC5", "url": "https://www.uniprot.org/uniprotkb/Q29S17", "locus": { "chromosome": "10", "start_pos": 13352814, "end_pos": 13356161, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005210", "url": "https://www.ensembl.org/id/ENSBTAG00000005210" } ] } } ], "crossref": [ { "id": "Q29S17", "url": "https://alphafold.ebi.ac.uk/entry/Q29S17", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005210", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616058", "url": "https://www.ncbi.nlm.nih.gov/gene/616058", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616058", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616058", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDPPNIM", "url": "https://omabrowser.org/oma/group/EDPPNIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q29S17", "url": "https://www.orthodb.org/?gene=Q29S17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15333:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15333:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15497", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15497", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040038", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29S17-1", "url": "https://www.uniprot.org/uniprotkb/Q29S17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRREGEMLPSQPAPEPSHDMLVHVDNEASINQTALELSTRSHVQEEEEEEEEEEEDS", "length": 98, "header": "sp|Q29S17-1|SNPC5_BOVIN Isoform 1 of snRNA-activating protein complex subunit 5 OS=Bos taurus OX=9913 GN=SNAPC5 PE=3 SV=1 CANONICAL=Q29S17-1" }, "isoforms": [ { "isoform_ac": "Q29S17-1", "url": "https://www.uniprot.org/uniprotkb/Q29S17/entry#Q29S17-1", "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRREGEMLPSQPAPEPSHDMLVHVDNEASINQTALELSTRSHVQEEEEEEEEEEEDS", "length": 98, "header": "sp|Q29S17-1|SNPC5_BOVIN Isoform 1 of snRNA-activating protein complex subunit 5 OS=Bos taurus OX=9913 GN=SNAPC5 PE=3 SV=1 CANONICAL=Q29S17-1" }, "locus": { "chromosome": "10", "start_pos": 13356131, "end_pos": 13353868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006862.4", "url": "https://www.ensembl.org/id/ENSBTAT00000006862.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006862.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006862.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616058", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616058", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-BTA-76071", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZWK5-1", "protein_name": "Small nuclear RNA activating complex polypeptide 5", "gene_name": "SNAPC5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMINSRRGDEMVSSQPAPQESHDMLVHVDNEASINQTALELSTRSHVPEEEEEEEEESDS", "length": 97 }, "evidence": [ { "id": "Q29S17", "url": "https://omabrowser.org/oma/group/Q29S17/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H8N2-1", "protein_name": "snRNA-activating protein complex subunit 5 isoform X3", "gene_name": "LOC113835540", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGTEMLSSQPAPEQLYDMSVHVDNEASINQTTLKLSTRSPMEEEEEEEEEESDS", "length": 97 }, "evidence": [ { "id": "Q29S17", "url": "https://omabrowser.org/oma/group/Q29S17/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75971-1", "protein_name": "snRNA-activating protein complex subunit 5", "gene_name": "SNAPC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS", "length": 98 }, "evidence": [ { "id": "Q29S17", "url": "https://omabrowser.org/oma/group/Q29S17/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R2K7-1", "protein_name": "snRNA-activating protein complex subunit 5", "gene_name": "Snapc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMINSRGRTETLSSQPAPEQLCDMSLHVDNEVTINQTTLKLSTRSPMEEEEEEEEEEEEEEESDS", "length": 102 }, "evidence": [ { "id": "Q29S17", "url": "https://omabrowser.org/oma/group/Q29S17/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" }, { "name": "snRNA transcription by RNA polymerase II", "id": "GO:0042795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042795", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" }, { "name": "snRNA transcription by RNA polymerase III", "id": "GO:0042796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042796", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" }, { "name": "RNA polymerase III general transcription initiation factor activity", "id": "GO:0000995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000995", "evidence": [ { "database": "UniProtKB", "id": "Q29S17", "url": "https://www.uniprot.org/uniprotkb/Q29S17" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q29S17-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 98, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q29S17-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q29S17" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABB1-1", "uniprot_ac": "Q2ABB1", "uniprot_id": "Q2ABB1_BOVIN", "mass": { "chemical_mass": 34667.0, "monoisotopic_mass": 34667.0 }, "refseq": { "ac": "NP_001040099", "name": "bitter taste receptor Bota-T2R65A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040099" }, "gene_names": [ { "name": "T2R65A", "type": "recommended", "evidence": [ { "id": "Q2ABB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1" } ] }, { "name": "T2R65A", "type": "synonym", "evidence": [ { "id": "NP_001040099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040099" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R65A", "type": "synonym", "evidence": [ { "id": "NP_001040099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040099" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABB1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "T2R65A", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1", "locus": { "chromosome": "5", "start_pos": 98626446, "end_pos": 98625559, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023258", "url": "https://www.ensembl.org/id/ENSBTAG00000023258" } ] } } ], "crossref": [ { "id": "ENSBTAG00000023258", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023258", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "664647", "url": "https://www.ncbi.nlm.nih.gov/gene/664647", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664647", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664647", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMFVMVI", "url": "https://omabrowser.org/oma/group/MMFVMVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABB1", "url": "https://www.orthodb.org/?gene=Q2ABB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040099", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABB1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABB1-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDFVRPHRQQPTRLPHPWDSPGKNTGVGCHFLLQCMKVKSQSEVAQLCLTPSDPMDCSLPGSSIHGIFQARVLEWGWALTNHLTIWFATCLSIFYFLKIASFSHFFFMWLKWRMNRVLLVLFLAFFFLLSFDLLMQDALGELWMNTFREPERNMTLHLDASKIFYLKSLILLRLTYVIPFLLSLASFLLFFLSLVRHIKNFQVNLNHSRDFSTEADKRATKMVTTFLHLVIVYFISILIGEWIFFKLHWYEVMMFVMVIPTLFSSGHSFVIILGNSKLRQIAFRLLWGLKFSKN", "length": 295, "header": "tr|Q2ABB1-1|Q2ABB1_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R65A PE=3 SV=1 CANONICAL=Q2ABB1-1" }, "isoforms": [ { "isoform_ac": "Q2ABB1-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1/entry#Q2ABB1-1", "sequence": { "sequence": "MSDFVRPHRQQPTRLPHPWDSPGKNTGVGCHFLLQCMKVKSQSEVAQLCLTPSDPMDCSLPGSSIHGIFQARVLEWGWALTNHLTIWFATCLSIFYFLKIASFSHFFFMWLKWRMNRVLLVLFLAFFFLLSFDLLMQDALGELWMNTFREPERNMTLHLDASKIFYLKSLILLRLTYVIPFLLSLASFLLFFLSLVRHIKNFQVNLNHSRDFSTEADKRATKMVTTFLHLVIVYFISILIGEWIFFKLHWYEVMMFVMVIPTLFSSGHSFVIILGNSKLRQIAFRLLWGLKFSKN", "length": 295, "header": "tr|Q2ABB1-1|Q2ABB1_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R65A PE=3 SV=1 CANONICAL=Q2ABB1-1" }, "locus": { "chromosome": "5", "start_pos": 98626443, "end_pos": 98625559, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031637.3", "url": "https://www.ensembl.org/id/ENSBTAT00000031637.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031587.2", "url": "https://www.ensembl.org/id/ENSBTAP00000031587.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664647", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664647", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 207, "end_pos": 209 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABB3-1", "uniprot_ac": "Q2ABB3", "uniprot_id": "Q2ABB3_BOVIN", "mass": { "chemical_mass": 35398.0, "monoisotopic_mass": 35398.0 }, "refseq": { "ac": "NP_001040094", "name": "taste receptor, type 2, member 46", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" }, "gene_names": [ { "name": "TAS2R46", "type": "recommended", "evidence": [ { "id": "Q2ABB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ] }, { "name": "T2R46", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] }, { "name": "TAS2R43", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] }, { "name": "TAS2R46", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R46", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] }, { "name": "taste receptor, type 2, member 43", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] }, { "name": "taste receptor, type 2, member 46", "type": "synonym", "evidence": [ { "id": "NP_001040094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAS2R46", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3", "locus": { "chromosome": "5", "start_pos": 98589680, "end_pos": 98588763, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030471", "url": "https://www.ensembl.org/id/ENSBTAG00000030471" } ] } } ], "crossref": [ { "id": "ENSBTAG00000030471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15027", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "664639", "url": "https://www.ncbi.nlm.nih.gov/gene/664639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664639", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664639", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INFIAWV", "url": "https://omabrowser.org/oma/group/INFIAWV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABB3", "url": "https://www.orthodb.org/?gene=Q2ABB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040094", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABB3-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MITLLSTIFSILGIIQFVLGNFANGFIALVNCIDWVKRQKISSTDVVVTAMAVSRIVLFCVMLIHWYYILLHPALYSLKVRTIFHVAWTISNHYSTWLATSLSIFYLLKIVNFSSLTFLHLKWRVKSVVLMMLLGTSFILVLQVVVISVSGTMQRSEFEGNFTQKTKLRDILWLSHVTLLILGNLTPFTMFLISFLLPIFSLCKHLRKMQLNGKGFQDPCTKVHIKAMQTVISFLLLFAFYFLVLIISIWRPKKLHEEPFLLLFPTVKVIYPSVHSFILIWGNRKLTQAFLLFLWQLGCWLKERK", "length": 305, "header": "tr|Q2ABB3-1|Q2ABB3_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R46 PE=3 SV=1 CANONICAL=Q2ABB3-1" }, "isoforms": [ { "isoform_ac": "Q2ABB3-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3/entry#Q2ABB3-1", "sequence": { "sequence": "MITLLSTIFSILGIIQFVLGNFANGFIALVNCIDWVKRQKISSTDVVVTAMAVSRIVLFCVMLIHWYYILLHPALYSLKVRTIFHVAWTISNHYSTWLATSLSIFYLLKIVNFSSLTFLHLKWRVKSVVLMMLLGTSFILVLQVVVISVSGTMQRSEFEGNFTQKTKLRDILWLSHVTLLILGNLTPFTMFLISFLLPIFSLCKHLRKMQLNGKGFQDPCTKVHIKAMQTVISFLLLFAFYFLVLIISIWRPKKLHEEPFLLLFPTVKVIYPSVHSFILIWGNRKLTQAFLLFLWQLGCWLKERK", "length": 305, "header": "tr|Q2ABB3-1|Q2ABB3_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R46 PE=3 SV=1 CANONICAL=Q2ABB3-1" }, "locus": { "chromosome": "5", "start_pos": 98589677, "end_pos": 98588763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043009.2", "url": "https://www.ensembl.org/id/ENSBTAT00000043009.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040607.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664639", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664639", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" } ], "orthologs": [ { "uniprot_canonical_ac": "P59543-1", "protein_name": "Taste receptor type 2 member 20", "gene_name": "TAS2R20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMSFLHIVFSILVVVAFILGNFANGFIALINFIAWVKRQKISSADQIIAALAVSRVGLLWVILLHWYSTVLNPTSSNLKVIIFISNAWAVTNHFSIWLATSLSIFYLLKIVNFSRLIFHHLKRKAKSVVLVIVLGSLFFLVCHLVMKHTYINVWTEECEGNVTWKIKLRNAMHLSNLTVAMLANLIPFTLTLISFLLLIYSLCKHLKKMQLHGKGSQDPSTKIHIKALQTVTSFLILLAIYFLCLIISFWNFKMRPKEIVLMLCQAFGIIYPSFHSFILIWGNKTLKQTFLSVLWQVTCWAKGQNQSTP", "length": 309 }, "evidence": [ { "id": "Q2ABB3", "url": "https://omabrowser.org/oma/group/Q2ABB3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TQA8-1", "protein_name": "Taste receptor type 2 member 136", "gene_name": "Tas2r136", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMSFLVSIASIAMLVKIVLGTFANVFIVLVNFTDCIKKRKFLLADRILTVLAIFRFDLLWIILMNWSSSVFHVGLYFQVRFCICVVWIVTNHFNTWLANILSILYLLKIDNFSNLIFLGLKGKIKCPYIVLLPCFVLLFPNLIMVTICETTQANGHQGNLTGKTKLTYFTNLIAMTFTLGSLVPFTTFMICFLLLICSLCKHLRTMRLYGKGSQGPSASTHIKVLQVLISFLLLFSMFILLLIISDYNYTKSLEEPIHLICQVIGTLYPSRHSYILLWGNKRIKQAFVLAMVQVRARFWLKEKKP", "length": 305 }, "evidence": [ { "id": "Q2ABB3", "url": "https://omabrowser.org/oma/group/Q2ABB3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB3", "url": "https://www.uniprot.org/uniprotkb/Q2ABB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 184, "end_pos": 186 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABB9-1", "uniprot_ac": "Q2ABB9", "uniprot_id": "Q2ABB9_BOVIN", "mass": { "chemical_mass": 35513.0, "monoisotopic_mass": 35513.0 }, "refseq": { "ac": "NP_001040095", "name": "bitter taste receptor Bota-T2R12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040095" }, "gene_names": [ { "name": "T2R12", "type": "recommended", "evidence": [ { "id": "Q2ABB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ] }, { "name": "T2R12", "type": "synonym", "evidence": [ { "id": "NP_001040095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040095" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R12", "type": "synonym", "evidence": [ { "id": "NP_001040095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040095" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "T2R12", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9", "locus": { "chromosome": "5", "start_pos": 98662824, "end_pos": 98661895, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030468", "url": "https://www.ensembl.org/id/ENSBTAG00000030468" } ] } } ], "crossref": [ { "id": "cd13950", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13950", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "664643", "url": "https://www.ncbi.nlm.nih.gov/gene/664643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FAGEFIM", "url": "https://omabrowser.org/oma/group/FAGEFIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABB9", "url": "https://www.orthodb.org/?gene=Q2ABB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF76", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF76", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040095", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABB9-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERTLNNILTIIYAGEFLLGILGNGFIVLVNCIDWIRSRKFSLIDFILTCLAISRICVLCIMISSTGLYVISKEIRYNKNLLINLRFLWTGSNYFSIVCTTCISVFYLLRIANFSNFLFLWMKWRIHKVLLIIALGAVFSFCLCLLQKDAVVESRLQNQVNSENNVTLDFLMIKYDLFLTIMFLIPFVVSLASFLLLILSLCGHLRRMNGVDCSSEAHVRALKAMISFLLLFVLYYLSTIITVWANHILGSFVAKIFVNMLLFFCPSGHTLLLILWNSKLKQASLCVLRKLKGYMNLRKPALPKRSLKR", "length": 309, "header": "tr|Q2ABB9-1|Q2ABB9_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R12 PE=3 SV=1 CANONICAL=Q2ABB9-1" }, "isoforms": [ { "isoform_ac": "Q2ABB9-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9/entry#Q2ABB9-1", "sequence": { "sequence": "MERTLNNILTIIYAGEFLLGILGNGFIVLVNCIDWIRSRKFSLIDFILTCLAISRICVLCIMISSTGLYVISKEIRYNKNLLINLRFLWTGSNYFSIVCTTCISVFYLLRIANFSNFLFLWMKWRIHKVLLIIALGAVFSFCLCLLQKDAVVESRLQNQVNSENNVTLDFLMIKYDLFLTIMFLIPFVVSLASFLLLILSLCGHLRRMNGVDCSSEAHVRALKAMISFLLLFVLYYLSTIITVWANHILGSFVAKIFVNMLLFFCPSGHTLLLILWNSKLKQASLCVLRKLKGYMNLRKPALPKRSLKR", "length": 309, "header": "tr|Q2ABB9-1|Q2ABB9_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R12 PE=3 SV=1 CANONICAL=Q2ABB9-1" }, "locus": { "chromosome": "5", "start_pos": 98662821, "end_pos": 98661895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043006.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043006.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040604.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040604.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664643", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3YU55-1", "protein_name": "Taste receptor type 2", "gene_name": "Tas2r122", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLLEIFFVIISVVEFIIGTLGNGFIVLINSTSWFKNQKISVIDFILTWLAISRMCVLWTTIAGASLRKFYKTLSYSKNFKFCFDIIWTGSNYLCIACTTCISVFYLFKIANFSNSIFFWIKQRIHAVLLAIVLGTLMYFILFLIFMKMIANNFIYKWTKLEQNTTFPVLDTLSGFLVYHSLYNGILIFFFIVSLTSFLLLIFSLWSHLRRMKLQGIHTKDISTEAHIKAMKTMMSFLLFFIIYYISNIMLIVASSILDNVVAQIFSYNLIFLYLSVHPFLLVLWNSKLKWTFQHVLRKLVCHCGGYS", "length": 309 }, "evidence": [ { "id": "Q2ABB9", "url": "https://omabrowser.org/oma/group/Q2ABB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "Q2ABB9", "url": "https://www.uniprot.org/uniprotkb/Q2ABB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 165, "end_pos": 167 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABC0-1", "uniprot_ac": "Q2ABC0", "uniprot_id": "Q2ABC0_BOVIN", "mass": { "chemical_mass": 35222.0, "monoisotopic_mass": 35222.0 }, "refseq": { "ac": "NP_001040096", "name": "bitter taste receptor Bota-T2R10C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040096" }, "gene_names": [ { "name": "T2R10C", "type": "recommended", "evidence": [ { "id": "Q2ABC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0" } ] }, { "name": "T2R10C", "type": "synonym", "evidence": [ { "id": "NP_001040096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040096" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R10C", "type": "synonym", "evidence": [ { "id": "NP_001040096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040096" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABC0", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "T2R10C", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0", "locus": { "chromosome": "5", "start_pos": 98761969, "end_pos": 98761040, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030461", "url": "https://www.ensembl.org/id/ENSBTAG00000030461" } ] } } ], "crossref": [ { "id": "ENSBTAG00000030461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "664644", "url": "https://www.ncbi.nlm.nih.gov/gene/664644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVICIIT", "url": "https://omabrowser.org/oma/group/CVICIIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABC0", "url": "https://www.orthodb.org/?gene=Q2ABC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040096", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABC0", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABC0-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSVLEGLLIFVALSESILGVLGDGFIGLAYFIECVKNKKFSTISFILMGLATSRICLIGLITTDGFVKIFSPEMYSSGYLIDCITYSWVILNPTSVFFATSLSIFYFLKIANFSHHIFLWLRSDVKRVLLLLIGYLLISWLVTFPLTMKIISDSRAKNRSVVFSVEVHKGEFFRNQILLNLGTLTIFILCLITCILLLISLRRHNQRMLLNATGFRDPSTEAHIKAMKVLISFIILFILYFIGITIEISCTTMSESKLLFIFGLTITALYPWGHSFILILGNNKLKQVFLRVLKQLKCWKKEKLLRTP", "length": 309, "header": "tr|Q2ABC0-1|Q2ABC0_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R10C PE=3 SV=1 CANONICAL=Q2ABC0-1" }, "isoforms": [ { "isoform_ac": "Q2ABC0-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0/entry#Q2ABC0-1", "sequence": { "sequence": "MLSVLEGLLIFVALSESILGVLGDGFIGLAYFIECVKNKKFSTISFILMGLATSRICLIGLITTDGFVKIFSPEMYSSGYLIDCITYSWVILNPTSVFFATSLSIFYFLKIANFSHHIFLWLRSDVKRVLLLLIGYLLISWLVTFPLTMKIISDSRAKNRSVVFSVEVHKGEFFRNQILLNLGTLTIFILCLITCILLLISLRRHNQRMLLNATGFRDPSTEAHIKAMKVLISFIILFILYFIGITIEISCTTMSESKLLFIFGLTITALYPWGHSFILILGNNKLKQVFLRVLKQLKCWKKEKLLRTP", "length": 309, "header": "tr|Q2ABC0-1|Q2ABC0_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=T2R10C PE=3 SV=1 CANONICAL=Q2ABC0-1" }, "locus": { "chromosome": "5", "start_pos": 98761966, "end_pos": 98761040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042999.2", "url": "https://www.ensembl.org/id/ENSBTAT00000042999.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040597.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040597.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664644", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7M725-1", "protein_name": "Taste receptor type 2 member 107", "gene_name": "Tas2r107", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLNSAEGILLCVVTSEAVLGVLGDTYIALFNCMDYAKNKKLSKIGFILIGLAISRIGVVWIIILQGYIQVFFPHMLTSGNITEYITYIWVFLNHLSVWFVTNLNILYFLKIANFSNSVFLWLKRRVNAVFIFLSGCLLTSWLLCFPQMTKILQNSKMHQRNTSWVHQRKNYFLINQSVTNLGIFFFIIVSLITCFLLIVFLWRHVRQMHSDVSGFRDHSTKVHVKAMKFLISFMVFFILHFVGLSIEVLCFILPQNKLLFITGLTATCLYPCGHSIIVILGNKQLKQASLKALQQLKCCETKGNFRVK", "length": 308 }, "evidence": [ { "id": "Q2ABC0", "url": "https://omabrowser.org/oma/group/Q2ABC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JKT9-1", "protein_name": "Taste receptor type 2 member 107", "gene_name": "Tas2r107", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSAAEGILLCVVTSEAVLGVLGDTFIALANCMEYAKNKKLSKIGFILIGLAISRIGVVWIIILQGYMQVFFPHILTFGNITEYITYIWVFLNHLSVWFATNLNILYFLKIANFSNSVFLWLKSRVRVVFIFLSGCLLTSWLLCFPQFSKMLNNSKMYWGNTSWLQQQKNVFLINQSLTNLGIFFFIIVSLITCFLLIVFLWRHIRQMHSDGSGLRDLNTEAHVKAMRVLISFAVLFILHFVGLSIQVLCFFLPQNNLLFITGLIATCLYPCGHSIILILGNKQLKQASLKALQHLTCCETKRNLSVT", "length": 308 }, "evidence": [ { "id": "Q2ABC0", "url": "https://omabrowser.org/oma/group/Q2ABC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC0", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC0", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC0", "url": "https://www.uniprot.org/uniprotkb/Q2ABC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 212, "end_pos": 214 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABC1-1", "uniprot_ac": "Q2ABC1", "uniprot_id": "Q2ABC1_BOVIN", "mass": { "chemical_mass": 35441.0, "monoisotopic_mass": 35441.0 }, "refseq": { "ac": "NP_001040092", "name": "bitter taste receptor T2R10B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040092" }, "gene_names": [ { "name": "BOTA-T2R10B", "type": "recommended", "evidence": [ { "id": "Q2ABC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1" } ] }, { "name": "BOTA-T2R10B", "type": "synonym", "evidence": [ { "id": "NP_001040092", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040092" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor T2R10B", "type": "synonym", "evidence": [ { "id": "NP_001040092", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040092" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABC1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOTA-T2R10B", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1", "locus": { "chromosome": "5", "start_pos": 98713666, "end_pos": 98712734, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030466", "url": "https://www.ensembl.org/id/ENSBTAG00000030466" } ] } } ], "crossref": [ { "id": "664637", "url": "https://www.ncbi.nlm.nih.gov/gene/664637", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664637", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664637", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IANYSHC", "url": "https://omabrowser.org/oma/group/IANYSHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABC1", "url": "https://www.orthodb.org/?gene=Q2ABC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040092", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABC1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABC1-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNIVEGLLIYVAVSESVLGVLGNGFIGVVSCIDCVKSKNISTVSLILTGLASSRFCLIWMIITDAYIRMFFPDIYLFGNISQYIVYLRIIMNQSSTWFATSLSIFYFLKIANYSHCIFLWLKCHINRVLLLFMGSLLISWLFAFPSIAKPSTNNIMKNRSTTWLITMHKSEYLTNQILLNIGVILVFVLCLITCFLLITSLWRHNRKTRLSATGFRDPSTEAHIKAMKILVSFIILFILYFVGTAIQISGSSTMPENKLLFIIGITTRLLYPWGHSLILMLGNRKLKQDSLRVLKPLKCWEKEKLLRIP", "length": 310, "header": "tr|Q2ABC1-1|Q2ABC1_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=BOTA-T2R10B PE=3 SV=1 CANONICAL=Q2ABC1-1" }, "isoforms": [ { "isoform_ac": "Q2ABC1-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1/entry#Q2ABC1-1", "sequence": { "sequence": "MLNIVEGLLIYVAVSESVLGVLGNGFIGVVSCIDCVKSKNISTVSLILTGLASSRFCLIWMIITDAYIRMFFPDIYLFGNISQYIVYLRIIMNQSSTWFATSLSIFYFLKIANYSHCIFLWLKCHINRVLLLFMGSLLISWLFAFPSIAKPSTNNIMKNRSTTWLITMHKSEYLTNQILLNIGVILVFVLCLITCFLLITSLWRHNRKTRLSATGFRDPSTEAHIKAMKILVSFIILFILYFVGTAIQISGSSTMPENKLLFIIGITTRLLYPWGHSLILMLGNRKLKQDSLRVLKPLKCWEKEKLLRIP", "length": 310, "header": "tr|Q2ABC1-1|Q2ABC1_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=BOTA-T2R10B PE=3 SV=1 CANONICAL=Q2ABC1-1" }, "locus": { "chromosome": "5", "start_pos": 98713663, "end_pos": 98712734, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043004.2", "url": "https://www.ensembl.org/id/ENSBTAT00000043004.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040602.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664637", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664637", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q67ES9-1", "protein_name": "Taste receptor type 2 member 104", "gene_name": "Tas2r104", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSMLESILLSVATSEAMLGILGNIFIVLVNCTNWVRNKKLSKINFILTGLAISRVFTIWIITLDAYTKVFFLTTLMPSNLHECISYIWVIINHLSVWFATSLSIFYFLKIANFSHYIFLWLKRRADKVFVFLIGYLIITWLASFPLAVTVIKNIKVHHNNTSWLIQLEKRELLINYVFANMGPISLFMVAVFTCFLLTISLWRHRRRMQSTGSKFRDLNTEVHVKAMKVLISFIILFILYFMGVLIETLCLFLTENILLFIFGFTLSSTYPCCHSFILILTSRELKQASMRALQRLKCCET", "length": 302 }, "evidence": [ { "id": "Q2ABC1", "url": "https://omabrowser.org/oma/group/Q2ABC1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7M723-1", "protein_name": "Taste receptor type 2 member 104", "gene_name": "Tas2r104", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSALESILLSVATSEAMLGVLGNTFIVLVNYTDWVRNKKLSKINFILTGLAISRIFTIWIITLDAYTKVFLLTMLMPSSLHECMSYIWVIINHLSVWFSTSLGIFYFLKIANFSHYIFLWMKRRADKVFVFLIVFLIITWLASFPLAVKVIKDVKIYQSNTSWLIHLEKSELLINYVFANMGPISLFIVAIIACFLLTISLWRHSRQMQSIGSGFRDLNTEAHMKAMKVLIAFIILFILYFLGILIETLCLFLTNNKLLFIFGFTLSAMYPCCHSFILILTSRELKQATMRALQRLKCCET", "length": 302 }, "evidence": [ { "id": "Q2ABC1", "url": "https://omabrowser.org/oma/group/Q2ABC1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABC2-1", "uniprot_ac": "Q2ABC2", "uniprot_id": "Q2ABC2_BOVIN", "mass": { "chemical_mass": 33907.0, "monoisotopic_mass": 33907.0 }, "refseq": { "ac": "NP_001040091", "name": "taste receptor, type 2, member 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091" }, "gene_names": [ { "name": "TAS2R10", "type": "recommended", "evidence": [ { "id": "Q2ABC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2" } ] }, { "name": "BOTA-T2R10A", "type": "synonym", "evidence": [ { "id": "NP_001040091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091" } ] }, { "name": "TAS2R10", "type": "synonym", "evidence": [ { "id": "NP_001040091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor T2R10A", "type": "synonym", "evidence": [ { "id": "NP_001040091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091" } ] }, { "name": "taste receptor, type 2, member 10", "type": "synonym", "evidence": [ { "id": "NP_001040091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABC2", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAS2R10", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2", "locus": { "chromosome": "5", "start_pos": 98750521, "end_pos": 98749622, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030463", "url": "https://www.ensembl.org/id/ENSBTAG00000030463" } ] } } ], "crossref": [ { "id": "ENSBTAG00000030463", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030463", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "664636", "url": "https://www.ncbi.nlm.nih.gov/gene/664636", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664636", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664636", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WLFTFPQ", "url": "https://omabrowser.org/oma/group/WLFTFPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABC2", "url": "https://www.orthodb.org/?gene=Q2ABC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040091", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABC2", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABC2-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSIVEGLLLFVAVNESVLGVLGNGFIGLVNCINCVKNKKISTLSLILTGLASSRFCLIWIITTDAYVRVFSPDMYLSGNLSQYIAYLWIIMNQSSVWFTTSLSIFYFLKIANFSHCIFLWLKGHITEILLLLMGCLPISWLFTFPNITMPFINNIMKNRSTTGLVTMQKSEYFINQILFNLGTFLVFVLCLITCFLIITSLWRHNRRMQLNATGFRDPSTEAHIKAMKILVSFIILFILYFVGTAIQILSVTVPENKLLFIFGMTTTILYPCGHSFILILGNSKLNQASLRVLKLLKC", "length": 299, "header": "tr|Q2ABC2-1|Q2ABC2_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R10 PE=3 SV=1 CANONICAL=Q2ABC2-1" }, "isoforms": [ { "isoform_ac": "Q2ABC2-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2/entry#Q2ABC2-1", "sequence": { "sequence": "MLSIVEGLLLFVAVNESVLGVLGNGFIGLVNCINCVKNKKISTLSLILTGLASSRFCLIWIITTDAYVRVFSPDMYLSGNLSQYIAYLWIIMNQSSVWFTTSLSIFYFLKIANFSHCIFLWLKGHITEILLLLMGCLPISWLFTFPNITMPFINNIMKNRSTTGLVTMQKSEYFINQILFNLGTFLVFVLCLITCFLIITSLWRHNRRMQLNATGFRDPSTEAHIKAMKILVSFIILFILYFVGTAIQILSVTVPENKLLFIFGMTTTILYPCGHSFILILGNSKLNQASLRVLKLLKC", "length": 299, "header": "tr|Q2ABC2-1|Q2ABC2_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R10 PE=3 SV=1 CANONICAL=Q2ABC2-1" }, "locus": { "chromosome": "5", "start_pos": 98750518, "end_pos": 98749622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043000.2", "url": "https://www.ensembl.org/id/ENSBTAT00000043000.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040598.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664636", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664636", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AYK0-1", "protein_name": "Taste receptor type 2", "gene_name": "TAS2R10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSIVESLLIFISVSQSILGFLGNGFIGLVTCIDCVKNKNISMISFILTGLATSRICLIWLIIIDGFIKIFFPDLYISGKLTEYISYSWVIVNHSSIWFATSLSIFYFLKIANFSHHIFLWLKGKINRVLLILMGYLFISWLFTFPQVVKIISDSKKKNGSSFWPLNMHKLEYFMSQFLLNLGVILLFILCMITCFLLIISLWRHNRQMQSNATGFRDPSTEAHIKAMKIVISFIILFILYFIGVAIEISCGTQPENKLLFIFGMITTAIFPWGHSFILILGNKKLKQASLKVLKQLKCWGKEKLLRTP", "length": 309 }, "evidence": [ { "id": "Q2ABC2", "url": "https://omabrowser.org/oma/group/Q2ABC2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7M722-1", "protein_name": "Taste receptor type 2 member 114", "gene_name": "Tas2r114", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMEGVLLSVSTSEAVLGIVGNTFIALVNCMDYNRNKKLSNIGFILTGLAISRICLVLILITEAYIKIFYPQLLSPVNIIELISYLWIIICQLNVWFATSLSIFYFLKIANFSHYIFVWLKRRIDLVFFFLIGCLLISWLFSFPVVAKMVKDNKMLYINTSWQIHMKKSELIINYVFTNGGVFLFFMIMLIVCFLLIISLWRHRRQMESNKLGFRDLNTEVHVRTIKVLLSFIILFILHFMGITINVICLLIPESNLLFMFGLTTAFIYPGCHSLILILANSRLKQCSVMILQLLKCCENGKELRDT", "length": 309 }, "evidence": [ { "id": "Q2ABC2", "url": "https://omabrowser.org/oma/group/Q2ABC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JKT8-1", "protein_name": "Taste receptor type 2 member 114", "gene_name": "Tas2r114", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGAMEGVLLSVATSEALLGIVGNTFIALVNCMDCTRNKNLYNIGFILTGLAISRICLVWILITEAYIKIFSPQLLSPINIIELISYLWIITSQLNVWFATSLSIFYFLKIANFSHHIFLWLKRRINIVFAFLIGCLLMSWLFSFPVVVKMVKDKKMLYINSSWQIHMKKSELIINYVFTNGGVFLLFIIMLIVCFLLIISLWRHSKWMQSNESGFRDLNTEVHVKTIKVLLSFIILFILHLIGITINVICLLVPENNLLFVFGLTIAFLYPCCHSLILILANSRLKRCFVRILQQLMCSEEGKEFRNT", "length": 309 }, "evidence": [ { "id": "Q2ABC2", "url": "https://omabrowser.org/oma/group/Q2ABC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NYW0-1", "protein_name": "Taste receptor type 2 member 10", "gene_name": "TAS2R10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRVVEGIFIFVVVSESVFGVLGNGFIGLVNCIDCAKNKLSTIGFILTGLAISRIFLIWIIITDGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFATSLSIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKTKNDTVWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCIFLIISLWRHNRQMQSNVTGLRDSNTEAHVKAMKVLISFIILFILYFIGMAIEISCFTVRENKLLLMFGMTTTAIYPWGHSFILILGNSKLKQASLRVLQQLKCCEKRKNLRVT", "length": 307 }, "evidence": [ { "id": "Q2ABC2", "url": "https://omabrowser.org/oma/group/Q2ABC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC2", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC2", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC2", "url": "https://www.uniprot.org/uniprotkb/Q2ABC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 147, "end_pos": 149 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 212, "end_pos": 214 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABC3-1", "uniprot_ac": "Q2ABC3", "uniprot_id": "Q2ABC3_BOVIN", "mass": { "chemical_mass": 33718.0, "monoisotopic_mass": 33718.0 }, "refseq": { "ac": "NP_001040100", "name": "taste receptor type 2 member 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" }, "gene_names": [ { "name": "TAS2R4", "type": "recommended", "evidence": [ { "id": "Q2ABC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ] }, { "name": "T2R4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] }, { "name": "TAS2R4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] }, { "name": "taste receptor T2R4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] }, { "name": "taste receptor type 2 member 4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] }, { "name": "taste receptor, type 2, member 4", "type": "synonym", "evidence": [ { "id": "NP_001040100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAS2R4", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3", "locus": { "chromosome": "4", "start_pos": 105050225, "end_pos": 105049335, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018440", "url": "https://www.ensembl.org/id/ENSBTAG00000018440" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018440", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018440", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "664648", "url": "https://www.ncbi.nlm.nih.gov/gene/664648", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664648", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664648", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MKLMIYF", "url": "https://omabrowser.org/oma/group/MKLMIYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABC3", "url": "https://www.orthodb.org/?gene=Q2ABC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040100", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABC3-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRIVFFSSVVVSEILTFVGLIVNLFIVVVSYKTCIKSHRISSSDRLLFSLGITRFFILLLNVVVIISPNMERSVSLSYFFLSCWMFLDCSSLWFVTLLNVLYCVKIANYQHSVFLLLKRNLTTKMPRLLLVCMLLSVFTTLLYIMLRQLAPSLEFVTMRNGTVFDINEGLLSLVTPLVLSSFLQFIINVTSASLLINSLKRHIQKMQRSATVLWNPQTEAHVGAMKLMICFLVLYIPYSVATLVHYLPPSIGMDLRTKSIYVIMSTIYPPGHSLLIILTHPKLKTKAKNILCFSK", "length": 296, "header": "tr|Q2ABC3-1|Q2ABC3_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R4 PE=3 SV=1 CANONICAL=Q2ABC3-1" }, "isoforms": [ { "isoform_ac": "Q2ABC3-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3/entry#Q2ABC3-1", "sequence": { "sequence": "MLRIVFFSSVVVSEILTFVGLIVNLFIVVVSYKTCIKSHRISSSDRLLFSLGITRFFILLLNVVVIISPNMERSVSLSYFFLSCWMFLDCSSLWFVTLLNVLYCVKIANYQHSVFLLLKRNLTTKMPRLLLVCMLLSVFTTLLYIMLRQLAPSLEFVTMRNGTVFDINEGLLSLVTPLVLSSFLQFIINVTSASLLINSLKRHIQKMQRSATVLWNPQTEAHVGAMKLMICFLVLYIPYSVATLVHYLPPSIGMDLRTKSIYVIMSTIYPPGHSLLIILTHPKLKTKAKNILCFSK", "length": 296, "header": "tr|Q2ABC3-1|Q2ABC3_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R4 PE=3 SV=1 CANONICAL=Q2ABC3-1" }, "locus": { "chromosome": "4", "start_pos": 105050222, "end_pos": 105049335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024537.4", "url": "https://www.ensembl.org/id/ENSBTAT00000024537.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024537.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024537.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664648", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664648", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HGL1-1", "protein_name": "Taste receptor type 2", "gene_name": "Tas2r4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLWQLYLFVFAASMIFSFVGIIANLLIIVVIYKTWIKSHRISPSDRILFSLAVTRFLTLCLFLLNSVYITTSAVRSVSFSTVFLLCWKFLDSNSLWLVTLLNSLYCVKITNFQQPVFLLLKRMVSAKTSSLLLACLLISAFTTLLYLVLTRISRFHEHVTGSNDTVFDLSEGILTLAASLVLSSLLQFMLNVTFASLLIHSLRRHVQKMKRNTSSFWNPQMEAHVGAMRLMICFLLLYIPYSIAALLYLPSYARKNMRAQAVCMIITAAYPPGHSVLLIITQHKLKAKAKQIFCFYK", "length": 297 }, "evidence": [ { "id": "Q2ABC3", "url": "https://omabrowser.org/oma/group/Q2ABC3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LE78-1", "protein_name": "Taste receptor type 2", "gene_name": "TAS2R4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRILFFSSVIISAILTFVGLIVNLFIAVVNCKTWVKSHRISSSDRILFSLSITRFFILGLNTLLFIIPNTARSVYFSTLFLTCWMFLDSNSLWFVTLLNALYCVKIANCQHSMFLLLKRNLSPKMPRLLLVCVLISAVTTLLYVVLRQVAPLPESVSGRNGTVFDINEGILSLLTPLVLSSLLQFILNVTAASLVINSLRRHVQRMHRNATVLWNPQTEAHLGAMKLMIYFLILYIPYSVVTLLHYLPSSVAVDLGAKSIYIIISTFYPPGHSVLILLTHPKLKTKAKKILCCNK", "length": 296 }, "evidence": [ { "id": "Q2ABC3", "url": "https://omabrowser.org/oma/group/Q2ABC3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q67ET0-1", "protein_name": "Taste receptor type 2 member 4", "gene_name": "Tas2r4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWELYAFVFAASVVFNFVGIVANLFIIVIISKTWVKSHKISSSDKILFSLAITRFLTLGLFLLNTVYIATNTGRSVYFSTFFLLCWKFLDSNSLWLVTFLNCLYCVKITHFQHPVFLLLKRTVSMKTTSLLLACLLISAFTTLLYFVLTQISRFPEHIIGRNDTLFDVSDGILTLAASLILSSLLQFLLNVTFASLLIHSLRRHVQKMQRNRSSFWNPQTEAHVGAMRLMICFLVLYIPYSIAALLYFPSYMRKNLRAQAACMIITAAYPPGHSILLIITHHKLKAKAKKICCFYKLRDFVSN", "length": 304 }, "evidence": [ { "id": "Q2ABC3", "url": "https://omabrowser.org/oma/group/Q2ABC3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JKT3-1", "protein_name": "Taste receptor type 2 member 4", "gene_name": "Tas2r4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLWELYVFVFAASVFLNFVGIIANLFIIVIIIKTWVNSRRIASPDRILFSLAITRFLTLGLFLLNSVYIATNTGRSVYFSTFFLLCWKFLDANSLWLVTILNSLYCVKITNFQHPVFLLLKRTISMKTTSLLLACLLISALTTLLYYMLSQISRFPEHIIGRNDTSFDLSDGILTLVASLVLNSLLQFMLNVTFASLLIHSLRRHIQKMQRNRTSFWNPQTEAHMGAMRLMICFLVLYIPYSIATLLYLPSYMRKNLRAQAICMIITAAYPPGHSVLLIITHHKLKAKAKKIFCFYK", "length": 297 }, "evidence": [ { "id": "Q2ABC3", "url": "https://omabrowser.org/oma/group/Q2ABC3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NYW5-1", "protein_name": "Taste receptor type 2 member 4", "gene_name": "TAS2R4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK", "length": 299 }, "evidence": [ { "id": "Q2ABC3", "url": "https://omabrowser.org/oma/group/Q2ABC3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC3", "url": "https://www.uniprot.org/uniprotkb/Q2ABC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2ABC5-1", "uniprot_ac": "Q2ABC5", "uniprot_id": "Q2ABC5_BOVIN", "mass": { "chemical_mass": 33958.0, "monoisotopic_mass": 33958.0 }, "refseq": { "ac": "NP_001040101", "name": "taste receptor type 2 member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" }, "gene_names": [ { "name": "TAS2R1", "type": "recommended", "evidence": [ { "id": "Q2ABC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ] }, { "name": "T2R1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] }, { "name": "TAS2R1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "Q2ABC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5/entry#names_and_taxonomy" } ] }, { "name": "bitter taste receptor Bota-T2R1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] }, { "name": "taste receptor T2R1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] }, { "name": "taste receptor type 2 member 1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] }, { "name": "taste receptor, type 2, member 1", "type": "synonym", "evidence": [ { "id": "NP_001040101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAS2R1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5", "locus": { "chromosome": "20", "start_pos": 63558518, "end_pos": 63557628, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032508", "url": "https://www.ensembl.org/id/ENSBTAG00000032508" } ] } } ], "crossref": [ { "id": "cd15016", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15016", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "664649", "url": "https://www.ncbi.nlm.nih.gov/gene/664649", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664649", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664649", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQRKMIP", "url": "https://omabrowser.org/oma/group/KQRKMIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2ABC5", "url": "https://www.orthodb.org/?gene=Q2ABC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040101", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2ABC5-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLESHLVSHLVLAVVHLLLGILVNGIIVIVNGTDFIKQRKLIPLDLLVSCLAISRMGIQLAFFYTNLALLSLIKFPQFTETLVVFTFVNDLGLWFATWLSVYYCTKIATIAHPLSFWLKMKISKLVPWLILVSLLYACSTSAMHVKYKWVFYGEDFLGLFFPNVTTHIKVTPTLQFAFLFAEFALPLFIFLISSLPLIFSLGRHAWQVRNTWTGPRNPHTRAYIRAFLSILSFLALYLCHYLIIALIFFQIFNLRSFLFLFCTFVVGSYHSVHSITLILGNPKMKQNAKALLLLRK", "length": 296, "header": "tr|Q2ABC5-1|Q2ABC5_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R1 PE=3 SV=1 CANONICAL=Q2ABC5-1" }, "isoforms": [ { "isoform_ac": "Q2ABC5-1", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5/entry#Q2ABC5-1", "sequence": { "sequence": "MLESHLVSHLVLAVVHLLLGILVNGIIVIVNGTDFIKQRKLIPLDLLVSCLAISRMGIQLAFFYTNLALLSLIKFPQFTETLVVFTFVNDLGLWFATWLSVYYCTKIATIAHPLSFWLKMKISKLVPWLILVSLLYACSTSAMHVKYKWVFYGEDFLGLFFPNVTTHIKVTPTLQFAFLFAEFALPLFIFLISSLPLIFSLGRHAWQVRNTWTGPRNPHTRAYIRAFLSILSFLALYLCHYLIIALIFFQIFNLRSFLFLFCTFVVGSYHSVHSITLILGNPKMKQNAKALLLLRK", "length": 296, "header": "tr|Q2ABC5-1|Q2ABC5_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R1 PE=3 SV=1 CANONICAL=Q2ABC5-1" }, "locus": { "chromosome": "20", "start_pos": 63558515, "end_pos": 63557628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000046105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000043431.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664649", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664649", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4F831-1", "protein_name": "Taste receptor type 2", "gene_name": "TAS2R1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLASHHTGYLLLAVIQFLIGVLVNGTIVVVNGIDLIQRRKLNPLALLISCLAISRIGLQFVLFCATLAGLSLIGFLQLAERPAIFLFVNESGLWFATWLSVFYCAKIATIPHPIFSWLKMRISRLVPWLILGSLVYAFSISVFQSKRKWIFSKEDLLALLSPNATNPFKEMPPLKLAFLSIELGLPLLIFLISVVLLIYSLGRHTQQMRNTAMGPRGPRTRVHVSALLSILVFLGLYVCHYTAAVLFFFQIFKLSSLRYFFCLLVIGSYHTGHSVNLILGNPKLKQIGKKLLLHRKCCQ", "length": 299 }, "evidence": [ { "id": "Q2ABC5", "url": "https://omabrowser.org/oma/group/Q2ABC5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9JKT2-1", "protein_name": "Taste receptor type 2 member 119", "gene_name": "Tas2r119", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMEGHMLFFLLVVVVQFLTGVLANGLIVVVNAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLGLSCLVRHTLFADNVTFVYIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILASVVYVTVTTFIHSRETSELPKQIFISFFSKNTTRVRPAHATLLSVFVFGLTLPFLIFTVAVLLLLSSLWNHSRQMRTMVGTREPSRHALVSAMLSILSFLILYLSHDMVAVLICTQGLHFGSRTFAFCLLVIGMYPSLHSIVLILGNPKLKRNAKTFIVHCKCCHCARAWVTSRNPRLSDLPVPATHHSANKTSCSEACIMPS", "length": 335 }, "evidence": [ { "id": "Q2ABC5", "url": "https://omabrowser.org/oma/group/Q2ABC5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JKU1-1", "protein_name": "Taste receptor type 2 member 119", "gene_name": "Tas2r119", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMEGHILFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVFIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNATQVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMVGTREYSGHAHISAMLSILSFLILYLSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAKMFIVHCKCCHCTRAWVTSRSPRLSDLPVPPTHPSANKTSCSEACIMPS", "length": 335 }, "evidence": [ { "id": "Q2ABC5", "url": "https://omabrowser.org/oma/group/Q2ABC5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NYW7-1", "protein_name": "Taste receptor type 2 member 1", "gene_name": "TAS2R1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFIWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRKFFSQNATIQKEDTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ", "length": 299 }, "evidence": [ { "id": "Q2ABC5", "url": "https://omabrowser.org/oma/group/Q2ABC5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "Q2ABC5", "url": "https://www.uniprot.org/uniprotkb/Q2ABC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ38-1", "uniprot_ac": "Q2HJ38", "uniprot_id": "CNN1_BOVIN", "mass": { "chemical_mass": 33283.0, "monoisotopic_mass": 33283.0 }, "refseq": { "ac": "NP_001039844", "name": "calponin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" }, "gene_names": [ { "name": "CNN1", "type": "recommended", "evidence": [ { "id": "Q2HJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ] }, { "name": "CNN1", "type": "synonym", "evidence": [ { "id": "NP_001039844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" } ] } ], "protein_names": [ { "name": "Calponin-1", "type": "recommended", "evidence": [ { "id": "Q2HJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38/entry#names_and_taxonomy" } ] }, { "name": "Basic calponin", "type": "synonym", "evidence": [ { "id": "Q2HJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38/entry#names_and_taxonomy" } ] }, { "name": "Calponin H1, smooth muscle", "type": "synonym", "evidence": [ { "id": "Q2HJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38/entry#names_and_taxonomy" } ] }, { "name": "basic calponin", "type": "synonym", "evidence": [ { "id": "NP_001039844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" } ] }, { "name": "calponin 1, basic, smooth muscle", "type": "synonym", "evidence": [ { "id": "NP_001039844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" } ] }, { "name": "calponin H1, smooth muscle", "type": "synonym", "evidence": [ { "id": "NP_001039844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" } ] }, { "name": "calponin-1", "type": "synonym", "evidence": [ { "id": "NP_001039844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844" } ] } ], "function": [ { "annotation": "Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNN1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38", "locus": { "chromosome": "7", "start_pos": 15891278, "end_pos": 15882825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011207", "url": "https://www.ensembl.org/id/ENSBTAG00000011207" } ] } } ], "crossref": [ { "id": "Q2HJ38", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011207", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011207", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21282", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21282", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534583", "url": "https://www.ncbi.nlm.nih.gov/gene/534583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534583", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534583", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GEPTHNH", "url": "https://omabrowser.org/oma/group/GEPTHNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ38", "url": "https://www.orthodb.org/?gene=Q2HJ38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039844", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ38-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA", "length": 297, "header": "sp|Q2HJ38-1|CNN1_BOVIN Isoform 1 of Calponin-1 OS=Bos taurus OX=9913 GN=CNN1 PE=2 SV=1 CANONICAL=Q2HJ38-1" }, "isoforms": [ { "isoform_ac": "Q2HJ38-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38/entry#Q2HJ38-1", "sequence": { "sequence": "MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA", "length": 297, "header": "sp|Q2HJ38-1|CNN1_BOVIN Isoform 1 of Calponin-1 OS=Bos taurus OX=9913 GN=CNN1 PE=2 SV=1 CANONICAL=Q2HJ38-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by ROCK2", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "site_lbl": "Thr170" }, { "start_pos": 175, "end_pos": 175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by ROCK2", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "site_lbl": "Ser175" }, { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by ROCK2", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "site_lbl": "Thr180" }, { "start_pos": 184, "end_pos": 184, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by ROCK2", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "site_lbl": "Thr184" }, { "start_pos": 259, "end_pos": 259, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by ROCK2", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "site_lbl": "Thr259" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534583", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534583", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IGU0-1", "protein_name": "Calponin", "gene_name": "cnn1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTQFKSGPAFGLSAEVKSKLAHKYDPQKEEELRMWISDVTGRKLPENFMEGLKDGVLLCELINTLQPGSVRKINNSPQNWHQLENIGNFVRAIQEYGLKPHEIFEANDLFENVNHTQVQSTLIALAGMAKSKGFHSKYDIGVKYAEKQQRRFAPEKLKEGRNIIGLQMGTNKFASQKGMTSYGTRRHLYDPKTGMENPLDQSTISLQMGTNKGASQAGMTAPGTKRQIFEKKLDMEMCDTSIVSLQMGTNKVASQTGMTVYGLPRQVYDSKYCSSANEYINNGQDSEMDGYQYSD", "length": 296 }, "evidence": [ { "id": "Q2HJ38", "url": "https://omabrowser.org/oma/group/Q2HJ38/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P51911-1", "protein_name": "Calponin-1", "gene_name": "CNN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA", "length": 297 }, "evidence": [ { "id": "Q2HJ38", "url": "https://omabrowser.org/oma/group/Q2HJ38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q08091-1", "protein_name": "Calponin-1", "gene_name": "Cnn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLNPEYPELSEPTHNHHPHNYYNSA", "length": 297 }, "evidence": [ { "id": "Q2HJ38", "url": "https://omabrowser.org/oma/group/Q2HJ38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q08290-1", "protein_name": "Calponin-1", "gene_name": "Cnn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGSNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELDEPTHNHHPHNYYNSA", "length": 297 }, "evidence": [ { "id": "Q2HJ38", "url": "https://omabrowser.org/oma/group/Q2HJ38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "pmid": "" }, { "name": "actomyosin structure organization", "id": "GO:0031032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ38", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ38" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2HJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ38" }, { "id": "PRU00044", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000255", "start_pos": 28, "end_pos": 131, "start_aa": "His", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 170, 175, 180, 184, 259 ], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 242, "end_pos": 244 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2HJ41-1", "uniprot_ac": "Q2HJ41", "uniprot_id": "PRP18_BOVIN", "mass": { "chemical_mass": 39832.0, "monoisotopic_mass": 39832.0 }, "refseq": { "ac": "NP_001068791", "name": "pre-mRNA-splicing factor 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791" }, "gene_names": [ { "name": "PRPF18", "type": "recommended", "evidence": [ { "id": "Q2HJ41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ] }, { "name": "PRPF18", "type": "synonym", "evidence": [ { "id": "NP_001068791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791" } ] } ], "protein_names": [ { "name": "Pre-mRNA-splicing factor 18", "type": "recommended", "evidence": [ { "id": "Q2HJ41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41/entry#names_and_taxonomy" } ] }, { "name": "PRP18 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791" }, { "id": "Q2HJ41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41/entry#names_and_taxonomy" } ] }, { "name": "PRP18 pre-mRNA processing factor 18 homolog", "type": "synonym", "evidence": [ { "id": "NP_001068791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791" } ] }, { "name": "pre-mRNA-splicing factor 18", "type": "synonym", "evidence": [ { "id": "NP_001068791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791" } ] } ], "function": [ { "annotation": "Participates in the second step of pre-mRNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPF18", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41", "locus": { "chromosome": "13", "start_pos": 28340069, "end_pos": 28284988, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017244", "url": "https://www.ensembl.org/id/ENSBTAG00000017244" } ] } } ], "crossref": [ { "id": "Q2HJ41", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017244", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017244", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507639", "url": "https://www.ncbi.nlm.nih.gov/gene/507639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507639", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507639", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SFAQVRW", "url": "https://omabrowser.org/oma/group/SFAQVRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVR3", "url": "https://www.orthodb.org/?gene=A0A3Q1LVR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ41", "url": "https://www.orthodb.org/?gene=Q2HJ41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13007", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13007", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13007:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13007:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068791", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P148", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P148", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P148-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P148-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ41-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVLKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKDEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNELVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342, "header": "sp|Q2HJ41-1|PRP18_BOVIN Isoform 1 of Pre-mRNA-splicing factor 18 OS=Bos taurus OX=9913 GN=PRPF18 PE=2 SV=1 CANONICAL=Q2HJ41-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVR3-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41/entry#A0A3Q1LVR3-1", "sequence": { "sequence": "MKMNLTCAVSGRVLGTPRSLHFGNGCFRLKVLENKKYFKRSELAKKEEEAYFERCGYKIQPKDEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNELVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 352, "header": "tr|A0A3Q1LVR3-1|A0A3Q1LVR3_BOVIN Computationally mapped isoform of Pre-mRNA-splicing factor 18 OS=Bos taurus OX=9913 GN=PRPF18 PE=3 SV=2 CANONICAL=Q2HJ41-1" }, "locus": { "chromosome": "13", "start_pos": 28338844, "end_pos": 28299160, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077640.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077640.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061262.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061262.2" } ] } }, { "isoform_ac": "A0ABI0P148-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41/entry#A0ABI0P148-1", "sequence": { "sequence": "MDVLKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKPINEKPSGEIQPKDEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNELVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 351, "header": "tr|A0ABI0P148-1|A0ABI0P148_BOVIN Computationally mapped isoform of Pre-mRNA-splicing factor 18 OS=Bos taurus OX=9913 GN=PRPF18 PE=3 SV=1 CANONICAL=Q2HJ41-1" }, "locus": { "chromosome": "13", "start_pos": 28338844, "end_pos": 28285105, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137512.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137512.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105107.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105107.1" } ] } }, { "isoform_ac": "Q2HJ41-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41/entry#Q2HJ41-1", "sequence": { "sequence": "MDVLKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKDEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNELVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342, "header": "sp|Q2HJ41-1|PRP18_BOVIN Isoform 1 of Pre-mRNA-splicing factor 18 OS=Bos taurus OX=9913 GN=PRPF18 PE=2 SV=1 CANONICAL=Q2HJ41-1" }, "locus": { "chromosome": "13", "start_pos": 28338844, "end_pos": 28285105, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022912.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022912.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022912.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022912.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507639", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507639", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VY37-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "PRPF18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDVLKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNELVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XMZ1-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "PRPF18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDILKREISRKRQQLEDKELGNKKYFKRSELAKKEEEAYFQRCGYKVQQQEEEENPLTSTNPVLELELAEEKLPMTLSRQEVIRRLRERGEPVRLFGETDYDAFQRLRKIEILAPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEAGDDDSQNDLKVHEENTTIEELEALGESLGRGDDHYDMDIITKFLKFLLGVWAKELNAREDYVKRGVQGKLNSATQKQTESYLRPLFRKLRKRTLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 340 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GVR0-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "Prpf18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKVQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6GMH0-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "prpf18", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDILKAEIARKRKLIEEKELIDDSKKYFKRAELARKEEEDYYRRCGYKMDKPEEEAPQSTSANPVLELELTEEKLPMTLSRQEVIRRLRERGEPIRLFGESDYDAFQRLRKIEILAPEVNKGLRNDLKAAMDKIDQQYLNEIVGGAEGAELDTQHDLKVHEENTTIEELEALGASLGNGNDVRDMDIINKVLRFLLGVWAKDLNSREDHIKRSVQGKLASATQKQTESYLEPLFRKLRKKNLPADIKESITDIIKFMLEREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BM39-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "Prpf18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDILKSEILRKRQLVEDRNLLVENKKYFKRSELARKEEEAYYERCGYKIQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL", "length": 342 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MML7-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "prp18", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSLSNLKEQLEKKRKEAQLKNSNNNNNNNNNNSNSNNGCDKSEEPATKKYKTRGEIDKELKQKKEEERIKKEKEKEKEKEKEKENYNNNNNSNVNSNKNENNINIDNDNDSNDKINKLKENEGFLPDIVVIQRLRERSQPITYFGETSIDRAMRLKKLEENDPIEYTQGDNEFANILKQIEQRKMKKHQDSADNEKEKEENENNDKKKQQQQQENEESEEQELERLRIDSSKCKESKILYFLKGLLNDWITNLENRSDDEKKSRQGKIAEATYYQCKSHIQPLFTSLREKTLSIDILEHINEIVEFCKSREYVRANDEYLQMAIGNAPWPMGVTMVGIHERSSREKIFSNQVAHVLNDEMQRKYIQAVKRLMTFCQTQYPTAPSRSIG", "length": 389 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SA55-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "PRP18A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLLREEILKKRKSLAEESGGKKFFKRSEIEQKKIQKLREEERREHELKAQRRAAAAASGGDGKSSGSAPGSSNAATSASSKSSASDAAAIADSKALTDENLILPRQEVIRRLRFLKQPMTLFGEDDQSRLDRLKYVLKEGLFEVDSDMTEGQTNDFLRDIAELKKRQKSGMMGDRKRKSRDERGRDEGDRGETREDELSGGESSDVDADKDMKRLKANFEDLCDEDKILVFYKKLLIEWKQELDAMENTERRTAKGKQMVATFKQCARYLVPLFNLCRKKGLPADIRQALMVMVNHCIKRDYLAAMDHYIKLAIGNAPWPIGVTMVGIHERSAREKIYTNSVAHIMNDETTRKYLQSVKRLMTFCQRRYPTMPSKAVEFNSLANGSDLQSLLAEERFFGGNREQVSEERLRLMPSQSES", "length": 420 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V437-1", "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "Prp18", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDILKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYIKQESVEAQGQTTEGAYSFVADGQNILPRTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEANRGFRNDFQEAMEQVDAAYLQEMFANTPTTKEDKKSDFAELDESVSWESIQTMAANMGRNKDYDMDVIITLLTFLLKLWNDQIANYSKHEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPEDILDSLRDICKHLLNRNYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYIQGLKRLMTKCQEYFPTDPSKCVEYVSKKDRE", "length": 340 }, "evidence": [ { "id": "Q2HJ41", "url": "https://omabrowser.org/oma/group/Q2HJ41/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "U5 snRNP", "id": "GO:0005682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005682", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "U4/U6 x U5 tri-snRNP complex", "id": "GO:0046540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "U2-type post-spliceosomal complex", "id": "GO:0071021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071021", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "generation of catalytic spliceosome for second transesterification step", "id": "GO:0000350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000350", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ41", "url": "https://www.uniprot.org/uniprotkb/Q2HJ41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ41-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 342, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ41-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ41" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ47-1", "uniprot_ac": "Q2HJ47", "uniprot_id": "DENR_BOVIN", "mass": { "chemical_mass": 22217.0, "monoisotopic_mass": 22217.0 }, "refseq": { "ac": "NP_001039993", "name": "density-regulated protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039993" }, "gene_names": [ { "name": "DENR", "type": "recommended", "evidence": [ { "id": "Q2HJ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ] }, { "name": "DENR", "type": "synonym", "evidence": [ { "id": "NP_001039993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039993" } ] } ], "protein_names": [ { "name": "Density-regulated protein", "type": "recommended", "evidence": [ { "id": "Q2HJ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47/entry#names_and_taxonomy" } ] }, { "name": "DRP", "type": "synonym", "evidence": [ { "id": "NP_001039993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039993" }, { "id": "Q2HJ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47/entry#names_and_taxonomy" } ] }, { "name": "density-regulated protein", "type": "synonym", "evidence": [ { "id": "NP_001039993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039993" } ] } ], "function": [ { "annotation": "May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENR", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47", "locus": { "chromosome": "29", "start_pos": 7664316, "end_pos": 7666635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068852", "url": "https://www.ensembl.org/id/ENSBTAG00000068852" } ] } } ], "crossref": [ { "id": "Q2HJ47", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032433", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11607", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11607", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614238", "url": "https://www.ncbi.nlm.nih.gov/gene/614238", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614238", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614238", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVFEIDM", "url": "https://omabrowser.org/oma/group/EVFEIDM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ47", "url": "https://www.orthodb.org/?gene=Q2HJ47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12789", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12789", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12789:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12789:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ47-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAADISESGGHDCRGDQRSNTKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198, "header": "sp|Q2HJ47-1|DENR_BOVIN Isoform 1 of Density-regulated protein OS=Bos taurus OX=9913 GN=DENR PE=2 SV=1 CANONICAL=Q2HJ47-1" }, "isoforms": [ { "isoform_ac": "Q2HJ47-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47/entry#Q2HJ47-1", "sequence": { "sequence": "MAADISESGGHDCRGDQRSNTKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198, "header": "sp|Q2HJ47-1|DENR_BOVIN Isoform 1 of Density-regulated protein OS=Bos taurus OX=9913 GN=DENR PE=2 SV=1 CANONICAL=Q2HJ47-1" }, "locus": { "chromosome": "29", "start_pos": 7666455, "end_pos": 7665862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110949.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110949.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081266.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 189, "end_pos": 189, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "site_lbl": "Ser189" }, { "start_pos": 73, "end_pos": 73, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "site_lbl": "Ser73" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "site_lbl": "Thr86" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614238", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614238", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UG52-1", "protein_name": "Density-regulated protein", "gene_name": "DENR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAADISESGGHDCKGDLKSNTKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGITEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N3T0-1", "protein_name": "Density-regulated protein", "gene_name": "Denr", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATDVSESSGADCKGDTRNSAKLDSEYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKPETGVSESQGTLGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZU54-1", "protein_name": "Density-regulated protein", "gene_name": "Denr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATDISESSGADTKNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGISEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 194 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43583-1", "protein_name": "Density-regulated protein", "gene_name": "DENR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAADISESSGADCKGDPRNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47089-1", "protein_name": "Translation machinery-associated protein 22", "gene_name": "TMA22", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTNKLAESSIGEAREEKLEKDLLKIQKKQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYIHSLLEEKGLKDVKVETIDAKKKKKPAAEGAAK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54WG0-1", "protein_name": "Density-regulated protein homolog", "gene_name": "denr", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDTESSTPSQPIVVVEYCKICSLPTEYCEYGPSAKQCLKENGPHPNNNKNTASGKDSSNTTATTTTTDTTTTTTTSTENTEEKLKDLKIVDDSKEVSHVDAGKSESKEATGEEKEKEKVSKKKKEVKPQIIIEVNQRNKRKHVTKITGLELYGIKLSDAAKVMAKKFSCGCSVVKSISNPNSEDIDIQGDFGEELVDLIEEKYPTVPLSEIYFLEDKKKVKAR", "length": 224 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZJ39-1", "protein_name": "Density-regulated protein", "gene_name": "DENR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATDVAEPVVPDCRGDIRSGARSDADYPLRVLYCGVCSLPTEYCEYMPDVTKCRQWLEKNFPDEFAKLTVENSPKQEAGVGEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6DH65-1", "protein_name": "Density-regulated protein", "gene_name": "denr", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATTENAESGSPENKVDRADPDAKYPLKVLYCGVCSLPAEYCEYMPEPAKCKQWLEKNFPDVFAKLTLGTAPKQESKGGGGGEDGGGGRGRGEAPPAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIELKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK", "length": 208 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CQJ6-1", "protein_name": "Density-regulated protein", "gene_name": "Denr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATDISESSGADCKGDTKNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 198 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VX98-1", "protein_name": "Density-regulated protein homolog", "gene_name": "DENR", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTNEDVGTNSVADRLQLGPREGVTYPIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRVKKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWAEIDEDVIEDLGDQKRT", "length": 189 }, "evidence": [ { "id": "Q2HJ47", "url": "https://omabrowser.org/oma/group/Q2HJ47/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation reinitiation", "id": "GO:0002188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002188", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "pmid": "" }, { "name": "formation of translation preinitiation complex", "id": "GO:0001731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001731", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ47", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ47-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ47-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ47" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2HJ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ47" }, { "id": "PRU00200", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUI1", "eco_id": "ECO_0000255", "start_pos": 115, "end_pos": 182, "start_aa": "Val", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 73, 86, 189 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ48-1", "uniprot_ac": "Q2HJ48", "uniprot_id": "KCTD1_BOVIN", "mass": { "chemical_mass": 29334.0, "monoisotopic_mass": 29334.0 }, "refseq": {}, "gene_names": [ { "name": "KCTD1", "type": "recommended", "evidence": [ { "id": "Q2HJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD1", "type": "recommended", "evidence": [ { "id": "Q2HJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Is a regulator of different signaling pathways. Up-regulates ADCY5 thereby enhancing cAMP signaling, and is involved in the negative regulation of Wnt canonical, Hh and Notch signaling (By similarity). Is a repressor of transcriptional activation mediated by AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48#function" }, { "database": "UniProtKB", "id": "Q719H9", "url": "https://www.uniprot.org/uniprotkb/Q719H9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48", "locus": { "chromosome": "24", "start_pos": 30438807, "end_pos": 30335802, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050380", "url": "https://www.ensembl.org/id/ENSBTAG00000050380" } ] } } ], "crossref": [ { "id": "Q2HJ48", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ48", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18387", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18387", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784587", "url": "https://www.ncbi.nlm.nih.gov/gene/784587", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784587", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784587", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJ48", "url": "https://www.orthodb.org/?gene=Q2HJ48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20871", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20871", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ48-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRESGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEVVGSCGGGVDSSQFSEYVLRRELRRTPRGPSVIRIKQEPLD", "length": 257, "header": "sp|Q2HJ48-1|KCTD1_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD1 OS=Bos taurus OX=9913 GN=KCTD1 PE=2 SV=1 CANONICAL=Q2HJ48-1" }, "isoforms": [ { "isoform_ac": "Q2HJ48-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48/entry#Q2HJ48-1", "sequence": { "sequence": "MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRESGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEVVGSCGGGVDSSQFSEYVLRRELRRTPRGPSVIRIKQEPLD", "length": 257, "header": "sp|Q2HJ48-1|KCTD1_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD1 OS=Bos taurus OX=9913 GN=KCTD1 PE=2 SV=1 CANONICAL=Q2HJ48-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "site_lbl": "Ser12" }, { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784587", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784587", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ48", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ48-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 257, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ48-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ48" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2HJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48#function" }, { "id": "Q2HJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ48" } ], "binding_site_uniprot": 222, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between homopentameric partners", "eco_id": "ECO_0000250", "start_pos": 222, "end_pos": 222, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9, 12 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ53-1", "uniprot_ac": "Q2HJ53", "uniprot_id": "CISH_BOVIN", "mass": { "chemical_mass": 28397.0, "monoisotopic_mass": 28397.0 }, "refseq": { "ac": "NP_001040051", "name": "cytokine-inducible SH2-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051" }, "gene_names": [ { "name": "CISH", "type": "recommended", "evidence": [ { "id": "Q2HJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ] }, { "name": "CISH", "type": "synonym", "evidence": [ { "id": "NP_001040051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051" } ] } ], "protein_names": [ { "name": "Cytokine-inducible SH2-containing protein", "type": "recommended", "evidence": [ { "id": "Q2HJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53/entry#names_and_taxonomy" } ] }, { "name": "CIS", "type": "synonym", "evidence": [ { "id": "NP_001040051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051" }, { "id": "Q2HJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53/entry#names_and_taxonomy" } ] }, { "name": "cytokine inducible SH2 protein", "type": "synonym", "evidence": [ { "id": "NP_001040051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051" } ] }, { "name": "cytokine-inducible SH2-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001040051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051" } ] } ], "function": [ { "annotation": "SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CISH", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53", "locus": { "chromosome": "22", "start_pos": 49755490, "end_pos": 49750073, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022622", "url": "https://www.ensembl.org/id/ENSBTAG00000022622" } ] } } ], "crossref": [ { "id": "Q2HJ53", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ53", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022622", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022622", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10718", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10718", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616753", "url": "https://www.ncbi.nlm.nih.gov/gene/616753", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616753", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616753", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LSEPIMQ", "url": "https://omabrowser.org/oma/group/LSEPIMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ53", "url": "https://www.orthodb.org/?gene=Q2HJ53", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10155:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10155:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040051", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ53-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKVVDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLATTPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLPRRMADYLRQYPFQL", "length": 254, "header": "sp|Q2HJ53-1|CISH_BOVIN Isoform 1 of Cytokine-inducible SH2-containing protein OS=Bos taurus OX=9913 GN=CISH PE=2 SV=1 CANONICAL=Q2HJ53-1" }, "isoforms": [ { "isoform_ac": "Q2HJ53-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53/entry#Q2HJ53-1", "sequence": { "sequence": "MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKVVDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLATTPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLPRRMADYLRQYPFQL", "length": 254, "header": "sp|Q2HJ53-1|CISH_BOVIN Isoform 1 of Cytokine-inducible SH2-containing protein OS=Bos taurus OX=9913 GN=CISH PE=2 SV=1 CANONICAL=Q2HJ53-1" }, "locus": { "chromosome": "22", "start_pos": 49754429, "end_pos": 49750176, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030652.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030652.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030624.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030624.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616753", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616753", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M3J1-1", "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "Cish", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLCVQGSCPLLAVEQTGQRPLWAQSLELPGPAMQPLPTGAFPEEVAEETPVQSESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCSADTRSDSPDPVPTPALPLPKQDASGDSALPLPMATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL", "length": 257 }, "evidence": [ { "id": "Q2HJ53", "url": "https://omabrowser.org/oma/group/Q2HJ53/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G1K2Y8-1", "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "CISH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLFPWPRSDMILCVPGPHPLLAEEKIQRLSLRGIAEDLTEHIMQPLPVPAFPEEPAPTFAAPEPDGSAPQTRDPEEDLLCIAKTFSYLRESGWYWGSITASEAKQHLQKMPEGTFLVRDSTHPSYLFTLSVKTNRGPTNVRIEYADSKFRLDSNYLSKPRILAFPDVVSLIQHYVTSCTTESKSEAPYPPPAPLPPVQKEVAVAAVHLKLLRPLGRRDSIPSLQHLCRLRINRCTTEVERLPLPRRMGDYLKQYPFQL", "length": 258 }, "evidence": [ { "id": "Q2HJ53", "url": "https://omabrowser.org/oma/group/Q2HJ53/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O70512-1", "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "Cish", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VLCVQGSCPLLVVEQIGQRPLWAQSLELPGPAMQPLPTGAFPEEVTEETPVQSENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPVSKPDAPGDPVLPIPVATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVTDVDCLPLPRRMADYLRQYPFQL", "length": 256 }, "evidence": [ { "id": "Q2HJ53", "url": "https://omabrowser.org/oma/group/Q2HJ53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q62225-1", "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "Cish", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLCVQGSCPLLAVEQIGRRPLWAQSLELPGPAMQPLPTGAFPEEVTEETPVQAENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDPAPTPALPMSKQDAPSDSVLPIPVATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL", "length": 257 }, "evidence": [ { "id": "Q2HJ53", "url": "https://omabrowser.org/oma/group/Q2HJ53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NSE2-1", "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "CISH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL", "length": 258 }, "evidence": [ { "id": "Q2HJ53", "url": "https://omabrowser.org/oma/group/Q2HJ53/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" }, { "name": "negative regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046426", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine receptor binding", "id": "GO:0005126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005126", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ53", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ53-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ53-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ53" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2HJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" }, { "id": "PRU00191", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 188, "start_aa": "Trp", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ53" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 205, "end_pos": 253, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ90-1", "uniprot_ac": "Q2HJ90", "uniprot_id": "LRC42_BOVIN", "mass": { "chemical_mass": 48585.0, "monoisotopic_mass": 48585.0 }, "refseq": { "ac": "NP_001039851", "name": "leucine-rich repeat-containing protein 42", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039851" }, "gene_names": [ { "name": "LRRC42", "type": "recommended", "evidence": [ { "id": "Q2HJ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90" } ] }, { "name": "LRRC42", "type": "synonym", "evidence": [ { "id": "NP_001039851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039851" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 42", "type": "recommended", "evidence": [ { "id": "Q2HJ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 42", "type": "synonym", "evidence": [ { "id": "NP_001039851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039851" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ90", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC42", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90", "locus": { "chromosome": "3", "start_pos": 92241257, "end_pos": 92262228, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019198", "url": "https://www.ensembl.org/id/ENSBTAG00000019198" } ] } } ], "crossref": [ { "id": "Q2HJ90", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ90", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019198", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019198", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534728", "url": "https://www.ncbi.nlm.nih.gov/gene/534728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534728", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534728", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYGKTHR", "url": "https://omabrowser.org/oma/group/FYGKTHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ90", "url": "https://www.orthodb.org/?gene=Q2HJ90", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31994:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31994:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039851", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ90", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ90-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYYLNSENHLDSGPIYVRENGQLHMVNLALDDVRSSLQKPRPFRLFPKGFSVELCMNREDDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTNEALSSVTQLRLKDNCLSDAGVRKMTAPVRVMKRGLENLSLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKHKLQTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVTLEAMKPQETLESRTAAQHFYGKRARTEAPGKYPLTEAHMNSSEKLQFYKEKAADCHGPLLKHEALSSQESKKSKKRAFEEPEKEQGSSSQTSKQKYVCLAVEDWDLLNSY", "length": 428, "header": "sp|Q2HJ90-1|LRC42_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 42 OS=Bos taurus OX=9913 GN=LRRC42 PE=2 SV=1 CANONICAL=Q2HJ90-1" }, "isoforms": [ { "isoform_ac": "Q2HJ90-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90/entry#Q2HJ90-1", "sequence": { "sequence": "MSYYLNSENHLDSGPIYVRENGQLHMVNLALDDVRSSLQKPRPFRLFPKGFSVELCMNREDDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTNEALSSVTQLRLKDNCLSDAGVRKMTAPVRVMKRGLENLSLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKHKLQTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVTLEAMKPQETLESRTAAQHFYGKRARTEAPGKYPLTEAHMNSSEKLQFYKEKAADCHGPLLKHEALSSQESKKSKKRAFEEPEKEQGSSSQTSKQKYVCLAVEDWDLLNSY", "length": 428, "header": "sp|Q2HJ90-1|LRC42_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 42 OS=Bos taurus OX=9913 GN=LRRC42 PE=2 SV=1 CANONICAL=Q2HJ90-1" }, "locus": { "chromosome": "3", "start_pos": 92256466, "end_pos": 92241483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043252.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043252.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040839.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040839.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 406, "end_pos": 406, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ90", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90" } ], "site_lbl": "Ser406" }, { "start_pos": 407, "end_pos": 407, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ90", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90" } ], "site_lbl": "Ser407" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534728", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534728", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZX40-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "LRRC42", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSYWLHSESHADAGPIYVRERGELHVVNAGAGGVQNAPRRARPLRLFSGGFSVELCLNGEDDRARRPRTDHFIFTYTKEGNLRYSAKSLFSLVLGYISDNVDHIDSLVGFPEQIAEKLFSAAEARQKFTEPVTGLRALQKFTEAYGSLVLCSLCLRNRYLLISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTKEALSSVKRLLLKDNALSDAGLRRMTAPVRVLKKGLQNLLVLDLSCNPKITDVGIGYLLCFKKLSCLDISGTGLKDVNAVVKRIQTQIGLVQSKVPLKEFDHSNCKTEGWAEQTVLQWEQAVMEAIKPQEDLRSRTAQHFYGKTHRIEEVVKCKLVEAEPKASGNLQFYKEDVQNCHLPLKKEVAGSHELKNNKKRALAEQERERTSKQKHLCLTVEDWDLLNTY", "length": 421 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GTM3-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "Lrrc42", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAYYLNSETHVDPGPIYVRENGQLHMVNLALDGVKNSLQKPRPFRLFPKGFSVELCMNREDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVIAEKLEEIKSFRELTRLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGIRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKDKLQTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVSVEAVRQRKDAESRKAAQYFYQKRALSEASRKCLLADTHMNSSGKLQFYREKVPDCHGPLLSQESKKSKKRAFEQSEQEQSAPQSAKQKCMCLAVEDWDLLNSY", "length": 420 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LVL0-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "LRRC42", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSYYLNSENHLDPGPIYVRENGQLHMVNLALDGVRSSLQKPRPFRLFPKGFSVELCMNREDDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGVRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKHKLQTHIGLIHSKVPLKEFDHSNCKTEGWADQIVLQWDRVTSEAVKPRETSEPRTAAQHFYGKRAPAEAPVKCPLADTHVNSSEKLQFYKEKAPDCCGPLLKCEAVSSQESKKSKKRAFEETEKEQNSSSQPSKQKYVCLAVEDWDLLNSY", "length": 428 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4KM95-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "Lrrc42", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAYYLNSEAHLDPGPIYVRENGQLHMVSLALDGVKNSLQKPRPFRLFPKGFSVELCMNREDDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVVAEKLEEIKSFRELTRLDLSCCWLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGIRKMTAPVRVLKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKDKLRTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVSVEAVRQRKDPEPRKAAQYFYQKRALTEASRKCPLAETHMNSSGKLQFYREKAPDCHEPLLSQESKKSKKRAFEESEQEQSSPQSAKQKCVCLAVEDWDLLNSY", "length": 421 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P5J6-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "lrrc42", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYLGEDCGAVYVRENGELRCVSAVKTVDPPPQNRLFTRDFTFQLCIDTLPSASRAERRDHFIFTYNKQGSLRYSVKTLFDISLQFIADHVEHVDSLVGFPEQMADKLFSAAEERGKFAELRTASRALQLFCEAYGELVLKSLCLRNRYLLISERLEEIRQFQSLECLDLYGCRLGDNHELFKYITSEALSSLVKLFMGANCLSDAGLQRLTAPVRVMKKGLENLQLLDLSENHITEKGLRYLTCFKTLQKLDLSGTKVMMDVSLKGFFRMMGMALSETPLMDFTHTACKTEGWAEQVINQWEITAAEVPKKDPKPRTNALRFYGREKFVREMLNSWSETSDATNKDKAVPIHFCKVDDCVQSSPSGETHSTHKSRKRRLSTEEEQSAAPVAKRLPLSVEDLHLLNSY", "length": 407 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8R2U7-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "Lrrc42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAYYLNSEAHLDPGPIYVRENGQLHMVNLALDGVKNSLQKPRPFRLFPKGFSVELCMNREDDTAQKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVVAEKLEEIKSFRELTRLDLSCCWLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGIRKMTAPVRVMKRGLENLALLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKAVKDKLRANIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVSVEAVRQRKDVEPRKAAQYFYQNRARTEVTRKCPLAETHMNSSGKLQFYREEAPDCHEPLLSQESKKSKKRAFKESEQEQSSPQSAKQKCVCLAVEDWDLLNSY", "length": 421 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y546-1", "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "LRRC42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYYLSSENHLDPGPIYMRENGQLHMVNLALDGVRSSLQKPRPFRLFPKGFSVELCMNREDDTARKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGVRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKTVKHKLQTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVTAEAVKPRETSEPRAAAQRFYGKRSRAEAPLKCPLADTHMNSSEKLQFYKEKAPDCHGPVLKHEAISSQESKKSKKRPFEESETEQNNSSQPSKQKYVCLAVEDWDLLNSY", "length": 428 }, "evidence": [ { "id": "Q2HJ90", "url": "https://omabrowser.org/oma/group/Q2HJ90/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ90", "url": "https://www.uniprot.org/uniprotkb/Q2HJ90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ90-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 428, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ90-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ90" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 406, 407 ], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 }, { "start_pos": 358, "end_pos": 360 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJ96-1", "uniprot_ac": "Q2HJ96", "uniprot_id": "GL8D2_BOVIN", "mass": { "chemical_mass": 40184.0, "monoisotopic_mass": 40184.0 }, "refseq": { "ac": "NP_001039731", "name": "glycosyltransferase 8 domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039731" }, "gene_names": [ { "name": "GLT8D2", "type": "recommended", "evidence": [ { "id": "Q2HJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96" } ] }, { "name": "GLT8D2", "type": "synonym", "evidence": [ { "id": "NP_001039731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039731" } ] } ], "protein_names": [ { "name": "Glycosyltransferase 8 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q2HJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "Q2HJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96/entry#names_and_taxonomy" } ] }, { "name": "glycosyltransferase 8 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039731" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJ96", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLT8D2", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96", "locus": { "chromosome": "5", "start_pos": 67653908, "end_pos": 67695908, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000925", "url": "https://www.ensembl.org/id/ENSBTAG00000000925" } ] } } ], "crossref": [ { "id": "Q2HJ96", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJ96", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000925", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000925", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523294", "url": "https://www.ncbi.nlm.nih.gov/gene/523294", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523294", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523294", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STINPMW", "url": "https://omabrowser.org/oma/group/STINPMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJ96", "url": "https://www.orthodb.org/?gene=Q2HJ96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13778", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13778", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13778:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13778:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039731", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJ96", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJ96-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLRKINQVLLFLLIVTLCGILYKKVHKGTMLRNEADDDSETPEEMEDEIPVVICAAAGRMGAAMAAINSIYSNTDANILFYVVGLRNTLSRIRKWIEHSKLREINFKIVEFNPVVLKGKIRPDSSRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSSQDIHRLVGLQNTYMGYLDYRKKTIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDTRYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFKLHHPNS", "length": 350, "header": "sp|Q2HJ96-1|GL8D2_BOVIN Isoform 1 of Glycosyltransferase 8 domain-containing protein 2 OS=Bos taurus OX=9913 GN=GLT8D2 PE=2 SV=1 CANONICAL=Q2HJ96-1" }, "isoforms": [ { "isoform_ac": "Q2HJ96-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96/entry#Q2HJ96-1", "sequence": { "sequence": "MALLRKINQVLLFLLIVTLCGILYKKVHKGTMLRNEADDDSETPEEMEDEIPVVICAAAGRMGAAMAAINSIYSNTDANILFYVVGLRNTLSRIRKWIEHSKLREINFKIVEFNPVVLKGKIRPDSSRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSSQDIHRLVGLQNTYMGYLDYRKKTIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDTRYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFKLHHPNS", "length": 350, "header": "sp|Q2HJ96-1|GL8D2_BOVIN Isoform 1 of Glycosyltransferase 8 domain-containing protein 2 OS=Bos taurus OX=9913 GN=GLT8D2 PE=2 SV=1 CANONICAL=Q2HJ96-1" }, "locus": { "chromosome": "5", "start_pos": 67677011, "end_pos": 67654169, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001224.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001224.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001224.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001224.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 234, "start_aa": "Asn", "end_pos": 234, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn234", "evidence": [ { "id": "Q2HJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523294", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523294", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAY8-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 2", "gene_name": "Glt8d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLRKINQVLLFLLVLTLCGILYKKVRKGAVLKNEADDDSESPEDVEEEIPVVICAAAGRMGAAMAAINSIYSNTDANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQDIHRLVGLQNTYMGYLDYRKKSIKELGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFRLNHKR", "length": 349 }, "evidence": [ { "id": "Q2HJ96", "url": "https://omabrowser.org/oma/group/Q2HJ96/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XZD7-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 2", "gene_name": "GLT8D2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALLKKINQILLLLLILTVCAILYNKVHKAPSALKNDAVDLESPMEMEEEIPVVICAAAGRMGATVAAISSIYSNTEANVLFYIVGLKNTIPHIRKWIENSKLKEIKFKTVEFNPMVLKGKIRQDASRPELLQPLNFVRFYLPLLIQKHEKVIYLDDDIIVQGDIQELYDTKLAPGHAAAFSDDCDLPSTHEMVRSVGMQNTYMGFLDYRKQAIRDLGISPSTCSFNPGVIVANMTEWKNQRLTKQLEKWMQRNVEENLYSSTLGGGVATSPMLIVFHGKHSTINPMWHIRHLGWSPDTRYSEHFLQEAKLLHWNGRYKPWDYPSVHTDLWENWFIPDPSGKFKLTRPDS", "length": 350 }, "evidence": [ { "id": "Q2HJ96", "url": "https://omabrowser.org/oma/group/Q2HJ96/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q640P4-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 2", "gene_name": "Glt8d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLRKVNQVLLLLLVLTLCGILYKKVHKGAVLKDKADVDSESPEDMEEEIPVVICAAAGRMGAAMAAINSIYSNTDANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQDIHRLVGLQNTYMGYLDYRKKTIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFKLHHNR", "length": 349 }, "evidence": [ { "id": "Q2HJ96", "url": "https://omabrowser.org/oma/group/Q2HJ96/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H1C3-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 2", "gene_name": "GLT8D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALLRKINQVLLFLLIVTLCVILYKKVHKGTVPKNDADDESETPEELEEEIPVVICAAAGRMGATMAAINSIYSNTDANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDSSRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQDINRLVGLQNTYMGYLDYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFKLNHHS", "length": 349 }, "evidence": [ { "id": "Q2HJ96", "url": "https://omabrowser.org/oma/group/Q2HJ96/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9LN68-1", "protein_name": "Probable galacturonosyltransferase-like 1", "gene_name": "GATL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSQHLLLLILLSLLLLHKPISATTIIQKFKEAPQFYNSADCPLIDDSESDDDVVAKPIFCSRRAVHVAMTLDAAYIRGSVAAVLSVLQHSSCPENIVFHFVASASADASSLRATISSSFPYLDFTVYVFNVSSVSRLISSSIRSALDCPLNYARSYLADLLPPCVRRVVYLDSDLILVDDIAKLAATDLGRDSVLAAPEYCNANFTSYFTSTFWSNPTLSLTFADRKACYFNTGVMVIDLSRWREGAYTSRIEEWMAMQKRMRIYELGSLPPFLLVFAGLIKPVNHRWNQHGLGGDNFRGLCRDLHPGPVSLLHWSGKGKPWARLDAGRPCPLDALWAPYDLLQTPFALDS", "length": 351 }, "evidence": [ { "id": "Q2HJ96", "url": "https://omabrowser.org/oma/group/Q2HJ96/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ96", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ96", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2HJ96", "url": "https://www.uniprot.org/uniprotkb/Q2HJ96" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJ96-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 350, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJ96-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJ96" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 234 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJA2-1", "uniprot_ac": "Q2HJA2", "uniprot_id": "DCA16_BOVIN", "mass": { "chemical_mass": 19513.0, "monoisotopic_mass": 19513.0 }, "refseq": { "ac": "NP_001071615", "name": "DDB1- and CUL4-associated factor 16", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615" }, "gene_names": [ { "name": "DCAF16", "type": "recommended", "evidence": [ { "id": "Q2HJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2" } ] }, { "name": "C4orf30", "type": "synonym", "evidence": [ { "id": "NP_001071615", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615" } ] }, { "name": "C6H4orf30", "type": "synonym", "evidence": [ { "id": "NP_001071615", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615" } ] }, { "name": "DCAF16", "type": "synonym", "evidence": [ { "id": "NP_001071615", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615" } ] } ], "protein_names": [ { "name": "DDB1- and CUL4-associated factor 16", "type": "recommended", "evidence": [ { "id": "Q2HJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2/entry#names_and_taxonomy" } ] }, { "name": "DDB1- and CUL4-associated factor 16", "type": "synonym", "evidence": [ { "id": "NP_001071615", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615" } ] } ], "function": [ { "annotation": "Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2#function" }, { "database": "UniProtKB", "id": "Q9NXF7", "url": "https://www.uniprot.org/uniprotkb/Q9NXF7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCAF16", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2", "locus": { "chromosome": "6", "start_pos": 37309247, "end_pos": 37332605, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062387", "url": "https://www.ensembl.org/id/ENSBTAG00000062387" } ] } } ], "crossref": [ { "id": "Q2HJA2", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "777600", "url": "https://www.ncbi.nlm.nih.gov/gene/777600", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:777600", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:777600", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJA2", "url": "https://www.orthodb.org/?gene=Q2HJA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16194:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16194:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15349", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15349", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071615", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJA2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPRNPSPDPLSESESEEEENTNYLNESSGEEWDSSEEEDPVVPNLTPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDASTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLISPSRLSRDHATLNGALQFATKQLSRTLSRATPHAFLPKLVPLAFSS", "length": 175, "header": "sp|Q2HJA2-1|DCA16_BOVIN Isoform 1 of DDB1- and CUL4-associated factor 16 OS=Bos taurus OX=9913 GN=DCAF16 PE=2 SV=1 CANONICAL=Q2HJA2-1" }, "isoforms": [ { "isoform_ac": "Q2HJA2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2/entry#Q2HJA2-1", "sequence": { "sequence": "MGPRNPSPDPLSESESEEEENTNYLNESSGEEWDSSEEEDPVVPNLTPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDASTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLISPSRLSRDHATLNGALQFATKQLSRTLSRATPHAFLPKLVPLAFSS", "length": 175, "header": "sp|Q2HJA2-1|DCA16_BOVIN Isoform 1 of DDB1- and CUL4-associated factor 16 OS=Bos taurus OX=9913 GN=DCAF16 PE=2 SV=1 CANONICAL=Q2HJA2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:777600", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:777600", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2" } ], "pmid": "" }, { "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 175, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJA2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 26, "end_pos": 28 }, { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJA8-1", "uniprot_ac": "Q2HJA8", "uniprot_id": "TMUB2_BOVIN", "mass": { "chemical_mass": 33911.0, "monoisotopic_mass": 33911.0 }, "refseq": { "ac": "NP_001039999", "name": "transmembrane and ubiquitin-like domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039999" }, "gene_names": [ { "name": "TMUB2", "type": "recommended", "evidence": [ { "id": "Q2HJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8" } ] }, { "name": "TMUB2", "type": "synonym", "evidence": [ { "id": "NP_001039999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039999" } ] } ], "protein_names": [ { "name": "Transmembrane and ubiquitin-like domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q2HJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane and ubiquitin-like domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039999" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJA8", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMUB2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8", "locus": { "chromosome": "19", "start_pos": 44009459, "end_pos": 44005513, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019660", "url": "https://www.ensembl.org/id/ENSBTAG00000019660" } ] } } ], "crossref": [ { "id": "Q2HJA8", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17132", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17132", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614388", "url": "https://www.ncbi.nlm.nih.gov/gene/614388", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614388", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614388", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJA8", "url": "https://www.orthodb.org/?gene=Q2HJA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14557", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14557", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14557:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14557:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039999", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJA8", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJA8-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJA8-2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISRHLQNNLMSVDPVSSQAMELSDVTLIEGVGNEVTVVAGVVVLILALVLAWLSTYVADSGSNPLLGTIVSAGDTSVLHLGHVDHLVAGQGTPEPTELPHPSEGNDEKAEEAGEGGGDPTGEPGAGGGVEPSLEHLLDIQGLPKRQAGPGNSSLEAPVRSEDSTCLPSSPSLISVRLKFFNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVAGPSSSLAPSSTTEPPNLGVSVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR", "length": 322, "header": "sp|Q2HJA8-1|TMUB2_BOVIN Isoform 1 of Transmembrane and ubiquitin-like domain-containing protein 2 OS=Bos taurus OX=9913 GN=TMUB2 PE=2 SV=2 CANONICAL=Q2HJA8-1" }, "isoforms": [ { "isoform_ac": "Q2HJA8-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8/entry#Q2HJA8-1", "sequence": { "sequence": "MISRHLQNNLMSVDPVSSQAMELSDVTLIEGVGNEVTVVAGVVVLILALVLAWLSTYVADSGSNPLLGTIVSAGDTSVLHLGHVDHLVAGQGTPEPTELPHPSEGNDEKAEEAGEGGGDPTGEPGAGGGVEPSLEHLLDIQGLPKRQAGPGNSSLEAPVRSEDSTCLPSSPSLISVRLKFFNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVAGPSSSLAPSSTTEPPNLGVSVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR", "length": 322, "header": "sp|Q2HJA8-1|TMUB2_BOVIN Isoform 1 of Transmembrane and ubiquitin-like domain-containing protein 2 OS=Bos taurus OX=9913 GN=TMUB2 PE=2 SV=2 CANONICAL=Q2HJA8-1" }, "locus": {} }, { "isoform_ac": "Q2HJA8-2", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8/entry#Q2HJA8-2", "sequence": { "sequence": "MELSDVTLIEGVGNEVTVVAGVVVLILALVLAWLSTYVADSGSNPLLGTIVSAGDTSVLHLGHVDHLVAGQGTPEPTELPHPSEGNDEKAEEAGEGGGDPTGEPGAGGGVEPSLEHLLDIQGLPKRQAGPGNSSLEAPVRSEDSTCLPSSPSLISVRLKFFNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVAGPSSSLAPSSTTEPPNLGVSVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR", "length": 302, "header": "sp|Q2HJA8-2|TMUB2_BOVIN Isoform 2 of Transmembrane and ubiquitin-like domain-containing protein 2 OS=Bos taurus OX=9913 GN=TMUB2 PE=2 SV=2 CANONICAL=Q2HJA8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614388", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614388", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA8", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q2HJA8", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 322, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2HJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJA8" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 174, "end_pos": 247, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 231, "end_pos": 233 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJE0-1", "uniprot_ac": "Q2HJE0", "uniprot_id": "ATGA1_BOVIN", "mass": { "chemical_mass": 25017.0, "monoisotopic_mass": 25017.0 }, "refseq": { "ac": "NP_001039599", "name": "autophagy-related protein 101", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599" }, "gene_names": [ { "name": "ATG101", "type": "recommended", "evidence": [ { "id": "Q2HJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ] }, { "name": "ATG101", "type": "synonym", "evidence": [ { "id": "NP_001039599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599" } ] }, { "name": "C12orf44", "type": "synonym", "evidence": [ { "id": "NP_001039599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599" } ] }, { "name": "C5H12orf44", "type": "synonym", "evidence": [ { "id": "NP_001039599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599" } ] } ], "protein_names": [ { "name": "Autophagy-related protein 101", "type": "recommended", "evidence": [ { "id": "Q2HJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0/entry#names_and_taxonomy" } ] }, { "name": "autophagy-related protein 101", "type": "synonym", "evidence": [ { "id": "NP_001039599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599" } ] } ], "function": [ { "annotation": "Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0#function" }, { "database": "UniProtKB", "id": "Q9BSB4", "url": "https://www.uniprot.org/uniprotkb/Q9BSB4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATG101", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0", "locus": { "chromosome": "5", "start_pos": 27808230, "end_pos": 27814034, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000510", "url": "https://www.ensembl.org/id/ENSBTAG00000000510" } ] } } ], "crossref": [ { "id": "Q2HJE0", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513049", "url": "https://www.ncbi.nlm.nih.gov/gene/513049", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513049", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513049", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TMNCRSE", "url": "https://omabrowser.org/oma/group/TMNCRSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJE0", "url": "https://www.orthodb.org/?gene=Q2HJE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13292:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13292:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039599", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJE0-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFRDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGSSVTTTMRRLIKDTLAL", "length": 218, "header": "sp|Q2HJE0-1|ATGA1_BOVIN Isoform 1 of Autophagy-related protein 101 OS=Bos taurus OX=9913 GN=ATG101 PE=2 SV=1 CANONICAL=Q2HJE0-1" }, "isoforms": [ { "isoform_ac": "Q2HJE0-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0/entry#Q2HJE0-1", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFRDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGSSVTTTMRRLIKDTLAL", "length": 218, "header": "sp|Q2HJE0-1|ATGA1_BOVIN Isoform 1 of Autophagy-related protein 101 OS=Bos taurus OX=9913 GN=ATG101 PE=2 SV=1 CANONICAL=Q2HJE0-1" }, "locus": { "chromosome": "5", "start_pos": 27810691, "end_pos": 27808531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000651.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000651.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000651.2", "url": "https://www.ensembl.org/id/ENSBTAP00000000651.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513049", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513049", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJH7-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFRDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGSSVTTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IIU3-1", "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGIQDVDCDFIDFTYVRVSSDELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMSRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGTSVTTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3B736-1", "protein_name": "Autophagy-related protein 101", "gene_name": "atg101", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVDEAMLGLLHTILLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTFVRVSSDELDRVIRKAVAEFKDALGNSGSDGMGQISLEFYQKKKSRWPFSDECIPWEVWSIKVNVVNLANEQERQICREKVGEKLGEKVINIVEVINRHEYLPKMPTQSEVDNVFDTSLKDVQPYLYKITYQITDSLGTSVSTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AY69-1", "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGIQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMSRHEYLPKMPTQSELDNVFDTGLRDVQPYLYKISFQITEALGTSVTTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BSB4-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGTSVTTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D8Z6-1", "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGIQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMSRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITEALGTSVTTTMRRLIKDTLAL", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VWQ1-1", "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNARSQVFDLTMEGRQVDEAVATIFHTVLFHRCLGKYMYTGDAQYSIGTVGYTDVDCNFIDFTYVCCTSDSLTHKVKRAINSFSEKLRSNESCGSGQISLEFFQKKKNRWPFPQESIPWEVWTVHLDLIKHENEDERQLCRENVSDLLTEKVIYITELMNRHDYVPKTPSQSELDLIFDTSFPDVQPYLFKFDYSTSGSAAPSMGNAMKKIIKETLAM", "length": 218 }, "evidence": [ { "id": "Q2HJE0", "url": "https://omabrowser.org/oma/group/Q2HJE0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "phagophore assembly site", "id": "GO:0000407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000407", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" }, { "name": "Atg1/ULK1 kinase complex", "id": "GO:1990316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990316", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE0", "url": "https://www.uniprot.org/uniprotkb/Q2HJE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJE0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJE9-1", "uniprot_ac": "Q2HJE9", "uniprot_id": "TI17B_BOVIN", "mass": { "chemical_mass": 18321.0, "monoisotopic_mass": 18321.0 }, "refseq": { "ac": "NP_001039953", "name": "mitochondrial import inner membrane translocase subunit Tim17-B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039953" }, "gene_names": [ { "name": "TIMM17B", "type": "recommended", "evidence": [ { "id": "Q2HJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9" } ] }, { "name": "TIMM17B", "type": "synonym", "evidence": [ { "id": "NP_001039953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039953" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim17-B", "type": "recommended", "evidence": [ { "id": "Q2HJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim17-B", "type": "synonym", "evidence": [ { "id": "NP_001039953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039953" } ] }, { "name": "translocase of inner mitochondrial membrane 17 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001039953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039953" } ] } ], "function": [ { "annotation": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM17B", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9", "locus": { "chromosome": "X", "start_pos": 87009815, "end_pos": 87013798, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018496", "url": "https://www.ensembl.org/id/ENSBTAG00000018496" } ] } } ], "crossref": [ { "id": "Q2HJE9", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "540765", "url": "https://www.ncbi.nlm.nih.gov/gene/540765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540765", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540765", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJE9", "url": "https://www.orthodb.org/?gene=Q2HJE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10485", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10485", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10485:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10485:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039953", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGMRHRLRGSVNAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSVPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPGQLPSKEGTPGPGYPSYQQYH", "length": 172, "header": "sp|Q2HJE9-1|TI17B_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim17-B OS=Bos taurus OX=9913 GN=TIMM17B PE=2 SV=1 CANONICAL=Q2HJE9-1" }, "isoforms": [ { "isoform_ac": "Q2HJE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9/entry#Q2HJE9-1", "sequence": { "sequence": "MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGMRHRLRGSVNAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSVPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPGQLPSKEGTPGPGYPSYQQYH", "length": 172, "header": "sp|Q2HJE9-1|TI17B_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim17-B OS=Bos taurus OX=9913 GN=TIMM17B PE=2 SV=1 CANONICAL=Q2HJE9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540765", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540765", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TIM23 mitochondrial import inner membrane translocase complex", "id": "GO:0005744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005744", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "Q2HJE9", "url": "https://www.uniprot.org/uniprotkb/Q2HJE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJE9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 172, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJE9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJE9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJF1-1", "uniprot_ac": "Q2HJF1", "uniprot_id": "RM53_BOVIN", "mass": { "chemical_mass": 11998.0, "monoisotopic_mass": 11998.0 }, "refseq": { "ac": "NP_001039391", "name": "large ribosomal subunit protein mL53", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" }, "gene_names": [ { "name": "MRPL53", "type": "recommended", "evidence": [ { "id": "Q2HJF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1" } ] }, { "name": "MRPL53", "type": "synonym", "evidence": [ { "id": "NP_001039391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL53", "type": "recommended", "evidence": [ { "id": "Q2HJF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L53, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001039391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" }, { "id": "Q2HJF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1/entry#names_and_taxonomy" } ] }, { "name": "L53mt", "type": "synonym", "evidence": [ { "id": "NP_001039391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" }, { "id": "Q2HJF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1/entry#names_and_taxonomy" } ] }, { "name": "MRP-L53", "type": "synonym", "evidence": [ { "id": "NP_001039391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" }, { "id": "Q2HJF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL53", "type": "synonym", "evidence": [ { "id": "NP_001039391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJF1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL53", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1", "locus": { "chromosome": "11", "start_pos": 10162298, "end_pos": 10159213, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016599", "url": "https://www.ensembl.org/id/ENSBTAG00000016599" } ] } } ], "crossref": [ { "id": "Q2HJF1", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016599", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016599", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505728", "url": "https://www.ncbi.nlm.nih.gov/gene/505728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505728", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505728", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKMWERI", "url": "https://omabrowser.org/oma/group/CKMWERI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJF1", "url": "https://www.orthodb.org/?gene=Q2HJF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33618", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33618", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33618:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33618:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039391", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJF1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJF1-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALARLGLRSVKQVRVQFCPFEKNVESTRTFLQAVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDGHRLIMRGAHLTAQEMLSAFASHIQARGAAASGDKPSASTGR", "length": 112, "header": "sp|Q2HJF1-1|RM53_BOVIN Isoform 1 of Large ribosomal subunit protein mL53 OS=Bos taurus OX=9913 GN=MRPL53 PE=1 SV=1 CANONICAL=Q2HJF1-1" }, "isoforms": [ { "isoform_ac": "Q2HJF1-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1/entry#Q2HJF1-1", "sequence": { "sequence": "MAAALARLGLRSVKQVRVQFCPFEKNVESTRTFLQAVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDGHRLIMRGAHLTAQEMLSAFASHIQARGAAASGDKPSASTGR", "length": 112, "header": "sp|Q2HJF1-1|RM53_BOVIN Isoform 1 of Large ribosomal subunit protein mL53 OS=Bos taurus OX=9913 GN=MRPL53 PE=1 SV=1 CANONICAL=Q2HJF1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] } ], "pathway": [ { "id": "bta:505728", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505728", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PKK3-1", "protein_name": "Large ribosomal subunit protein mL53", "gene_name": "MRPL53", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASRIRVVLRPVKSIVVRFCPFESNVESTRKFLQCINHKRIQATNRNCEVSADVRHDGSEPLVDVMFADGERLIMKGANLTTVEMLTALGSRCNAKELKAEQKSKKNP", "length": 108 }, "evidence": [ { "id": "Q2HJF1", "url": "https://omabrowser.org/oma/group/Q2HJF1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A3L7H729-1", "protein_name": "Large ribosomal subunit protein mL53", "gene_name": "Mrpl53", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASALARVGLKPVKLVRVQFCPFEKNVESTRTFLQAVSSEKVRATNLNCSVVADVRHDGSEPCVDVLFGDGYRLIMRSANLTAQEMFTALASHIRARNAAAASAAANADKPGPVNGTRR", "length": 119 }, "evidence": [ { "id": "Q2HJF1", "url": "https://omabrowser.org/oma/group/Q2HJF1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96EL3-1", "protein_name": "Large ribosomal subunit protein mL53", "gene_name": "MRPL53", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAALARLGLRPVKQVRVQFCPFEKNVESTRTFLQTVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDGHRLIMRGAHLTALEMLTAFASHIRARDAAGSGDKPGADTGR", "length": 112 }, "evidence": [ { "id": "Q2HJF1", "url": "https://omabrowser.org/oma/group/Q2HJF1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D1H8-1", "protein_name": "Large ribosomal subunit protein mL53", "gene_name": "Mrpl53", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAALARLGLRPVKLVRVQFCPFEKNVESTRTFLQTVSSEKVRATNLNCSVIADVRHDGSEPCVDVLFGDGYRLIMRGAHLTTQEMLSALASHIRDRNAAAASAPGADKVAPGTSTRR", "length": 118 }, "evidence": [ { "id": "Q2HJF1", "url": "https://omabrowser.org/oma/group/Q2HJF1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJF1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 112, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJF1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJF1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2HJF2-1", "uniprot_ac": "Q2HJF2", "uniprot_id": "FXL22_BOVIN", "mass": { "chemical_mass": 25507.0, "monoisotopic_mass": 25507.0 }, "refseq": { "ac": "NP_001039621", "name": "F-box and leucine-rich protein 22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039621" }, "gene_names": [ { "name": "FBXL22", "type": "recommended", "evidence": [ { "id": "Q2HJF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ] }, { "name": "FBXL22", "type": "synonym", "evidence": [ { "id": "NP_001039621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039621" } ] } ], "protein_names": [ { "name": "F-box and leucine-rich protein 22", "type": "recommended", "evidence": [ { "id": "Q2HJF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich protein 22", "type": "synonym", "evidence": [ { "id": "NP_001039621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039621" } ] }, { "name": "F-box/LRR-repeat protein 22", "type": "synonym", "evidence": [ { "id": "NP_001039621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039621" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2#function" }, { "database": "UniProtKB", "id": "Q6P050", "url": "https://www.uniprot.org/uniprotkb/Q6P050#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL22", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2", "locus": { "chromosome": "10", "start_pos": 46403395, "end_pos": 46408235, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057956", "url": "https://www.ensembl.org/id/ENSBTAG00000057956" } ] } } ], "crossref": [ { "id": "Q2HJF2", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22129", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22129", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513821", "url": "https://www.ncbi.nlm.nih.gov/gene/513821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJF2", "url": "https://www.orthodb.org/?gene=Q2HJF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039621", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJF2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHITQLNRECLLHLFSFLDKDSRKNLARTCPQLQDVFEDPALWPLLHFRSLTELKKDNFLLSPALRSLSICWHSSRVQVCSIEDWLKSALQRNICSRHESLVNDFLLQVCDRCPNLASVTLSGCGHVTDDCLARLLRCCPRLRALHLENCARVTNRTLTAVAAHGRALQTLHVDFCRNVSAAGLRRLRAACPRLTLRAEHSAAMIPDQLPRGPHAPGAALRKLLLR", "length": 226, "header": "sp|Q2HJF2-1|FXL22_BOVIN Isoform 1 of F-box and leucine-rich protein 22 OS=Bos taurus OX=9913 GN=FBXL22 PE=2 SV=1 CANONICAL=Q2HJF2-1" }, "isoforms": [ { "isoform_ac": "Q2HJF2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2/entry#Q2HJF2-1", "sequence": { "sequence": "MHITQLNRECLLHLFSFLDKDSRKNLARTCPQLQDVFEDPALWPLLHFRSLTELKKDNFLLSPALRSLSICWHSSRVQVCSIEDWLKSALQRNICSRHESLVNDFLLQVCDRCPNLASVTLSGCGHVTDDCLARLLRCCPRLRALHLENCARVTNRTLTAVAAHGRALQTLHVDFCRNVSAAGLRRLRAACPRLTLRAEHSAAMIPDQLPRGPHAPGAALRKLLLR", "length": 226, "header": "sp|Q2HJF2-1|FXL22_BOVIN Isoform 1 of F-box and leucine-rich protein 22 OS=Bos taurus OX=9913 GN=FBXL22 PE=2 SV=1 CANONICAL=Q2HJF2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513821", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF2", "url": "https://www.uniprot.org/uniprotkb/Q2HJF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJF2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJF2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 178, "end_pos": 180 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJF3-1", "uniprot_ac": "Q2HJF3", "uniprot_id": "ORC6_BOVIN", "mass": { "chemical_mass": 28080.0, "monoisotopic_mass": 28080.0 }, "refseq": { "ac": "NP_001039666", "name": "origin recognition complex subunit 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666" }, "gene_names": [ { "name": "ORC6", "type": "recommended", "evidence": [ { "id": "Q2HJF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ] }, { "name": "ORC6L", "type": "synonym", "evidence": [ { "id": "NP_001039666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666" }, { "id": "Q2HJF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ] }, { "name": "ORC6", "type": "synonym", "evidence": [ { "id": "NP_001039666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666" } ] } ], "protein_names": [ { "name": "Origin recognition complex subunit 6", "type": "recommended", "evidence": [ { "id": "Q2HJF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3/entry#names_and_taxonomy" } ] }, { "name": "origin recognition complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001039666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666" } ] }, { "name": "origin recognition complex, subunit 6 like", "type": "synonym", "evidence": [ { "id": "NP_001039666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666" } ] } ], "function": [ { "annotation": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORC6", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3", "locus": { "chromosome": "18", "start_pos": 15021378, "end_pos": 15013053, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001872", "url": "https://www.ensembl.org/id/ENSBTAG00000001872" } ] } } ], "crossref": [ { "id": "Q2HJF3", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001872", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001872", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11583", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11583", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16075", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16075", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515476", "url": "https://www.ncbi.nlm.nih.gov/gene/515476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515476", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKSHYLN", "url": "https://omabrowser.org/oma/group/RKSHYLN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJF3", "url": "https://www.orthodb.org/?gene=Q2HJF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13394:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13394:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05460", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05460", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21913", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21913", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176187", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68962", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039666", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJF3-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESGLIRRLAPRLGIAEQEVLRKAEEYLRLSRVKCVGLSARTTETSNAVMCLDLAASCMKCPLDRAYLIKLSGLNKKMYQSCLKSFECLLGLNSNIGIRDLAVQFSCTEAVNLASKILQSYESSLPQTQQVDLDLSRPLFTTAALLSACKILKLKVDRNKMAATSGVKKAIFDRLCKQLEKIGQQIDREAGDSVTPPQKKKKTVIEPSAKEIENVVETLPKPQKDEDLTQDYEEWKRNILENAARAQKAATQ", "length": 252, "header": "sp|Q2HJF3-1|ORC6_BOVIN Isoform 1 of Origin recognition complex subunit 6 OS=Bos taurus OX=9913 GN=ORC6 PE=2 SV=1 CANONICAL=Q2HJF3-1" }, "isoforms": [ { "isoform_ac": "Q2HJF3-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3/entry#Q2HJF3-1", "sequence": { "sequence": "MESGLIRRLAPRLGIAEQEVLRKAEEYLRLSRVKCVGLSARTTETSNAVMCLDLAASCMKCPLDRAYLIKLSGLNKKMYQSCLKSFECLLGLNSNIGIRDLAVQFSCTEAVNLASKILQSYESSLPQTQQVDLDLSRPLFTTAALLSACKILKLKVDRNKMAATSGVKKAIFDRLCKQLEKIGQQIDREAGDSVTPPQKKKKTVIEPSAKEIENVVETLPKPQKDEDLTQDYEEWKRNILENAARAQKAATQ", "length": 252, "header": "sp|Q2HJF3-1|ORC6_BOVIN Isoform 1 of Origin recognition complex subunit 6 OS=Bos taurus OX=9913 GN=ORC6 PE=2 SV=1 CANONICAL=Q2HJF3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 195, "end_pos": 195, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "site_lbl": "Thr195" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "site_lbl": "Thr229" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515476", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515476", "resource": "KEGG Pathway" }, { "id": "R-BTA-176187", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "resource": "Reactome", "description": "Activation of ATR in response to replication stress" }, { "id": "R-BTA-68616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68616", "resource": "Reactome", "description": "Assembly of the ORC complex at the origin of replication" }, { "id": "R-BTA-68689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "resource": "Reactome", "description": "CDC6 association with the ORC:origin complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-68962", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "resource": "Reactome", "description": "Activation of the pre-replicative complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1UKC8-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "ORC6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSGLIRRLAPRLGIAEPEVLRKAEEYLRLSHVKCIGLSAHTTETSNAVMCLDLAASCMKCPLDRAYLIKLSGLNKKMYQNCLKSFEYLLGLNSNIGIRDLAVQFSCTEAVNMASKILQSYESSLPQTQHVDLDLSRPLFTTAALLSACKILKLKVDKNKMTATSGVKKAIFDRLCKQLEKIGQQIDREPEDSATPPRKKKKTVVEPPAKETENIVEIPHKSQKDEDVTQDYEEWKRKILENAAKAQKATTE", "length": 252 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A1P6-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "ORC6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERGAVRELAARLGLGEPRVVRYRGAGLGSKEGVAGGACPACTGPGTRGGTRTRLRCHLRVTAVFCRKAEEYLRLSQVKCAGLTAHVTATGLAVMCLELAARCAKHPAAKSSFVKLSGLNRTAYQSSMQALECLLGLNARLGMRDLAVRFCCTEAVKAASEILQRYESSLPEAQQIDLDFSKPLFITAALFTACRCLKLKVDKAKMLAISGVKKAIFDRLCNQMEKISQQLSKDDIPLAAETSETLQTDLEQREEEGSEDYDEIPCKQPKTETKQDYEEWKRRILENAAKAQETNSGSVSIVPPCNITTACS", "length": 312 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7FAH8-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "Orc6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESDLVRHLARRLGLGEPSVLRKAEEYLRLSKVKCVSLSAHTSETSNAVICLDLAASCRKCPLDRAYLIKLSGLNKKMYQSCLKSFECLLGLNSNIGLRDLAVQFSCTEAVNLAAGILQSYESSLPEAQRADLDLSRPLFTTAALLSACKILKIKVDKTKMITTSGVKKTIFDRLCTQLEKIGQQINRDSADLASPALKKKKPAFSPALKKKKSGLEQPAKDIEVIETSDKLPKDAGLTQDYEEWKRKILENAAKAQTAAVE", "length": 262 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I8H4-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "Orc6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASELVRRLAPRLGLAEPGVLRKAEEYLRLSKVRCSSLSAHSSETSSAVICLDLAASCMKCPLDRAYLIKLSGLNRKMYQSCLKSFECLLGLNSNIGIRDLAVQFDCTEAVDMASNILQSYESSLTEAQQADLDLSRPLFTTAALLSACRILKLKVDKTKMITTSGVKKAIFDRLCKQLEKIGQQVNRDSGDLASPALKKKKPLVELPAKELKEVIETPHKPRKDEGLTQDYEEWKRKILENAAKAQTAIAE", "length": 252 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9Y1B2-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "Orc6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTTLIEQLITKMGLREEPNVLEKTTELVRLLELRSTNVPLQINEYGKIVLCADLASCMIGIAFDKEQALKLSGLRKSQYLNNKRMFEKLLDLNKLASVNDICVQLGLNEVARKAEELMTLFKGVAATEDMGTDTSHPQYATMAVFQACRLLKKKVSKSKLMPFSNLRPSQFQLLEQQWERMIAKHHKESKVPSSTDMEGKLKENQNENIKGHEAKKAHKPPPEDYEIWKARMLAKAQAKLKELEASQSHMDSQLLEA", "length": 257 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y5N6-1", "protein_name": "Origin recognition complex subunit 6", "gene_name": "ORC6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE", "length": 252 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ZVH3-1", "protein_name": "Origin of replication complex subunit 6", "gene_name": "ORC6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDISDIGRKLSLDNNKLLIRKAAEIRRLCDAQFDSSIIGVGEICKAVICLEIAATRLQIIFDRQAAVKLSGMSEKAYSRSFNSLQNVIGIKIKLNVRELAVQFGCVRVIKSVQNVLSSYKERFLASLPASRRANADFTRPVFTAAAFYLCAKKQKLKVDKLRLIEVCGTSESEFSCVSTSMTDLCFDCVGISKEKKDAKDVKGNRDLLDVLPGKRRLEDGGYSSGDESSCYKRHKKMEEAKYEDWKSTVVNSIKKNPEKGTKRVIQASLNFPKKSETKELQVDS", "length": 284 }, "evidence": [ { "id": "Q2HJF3", "url": "https://omabrowser.org/oma/group/Q2HJF3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear origin of replication recognition complex", "id": "GO:0005664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005664", "evidence": [ { "database": "UniProtKB", "id": "Q2HJF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJF3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 252, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJF3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJF3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 195, 229 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJG7-1", "uniprot_ac": "Q2HJG7", "uniprot_id": "CHUR_BOVIN", "mass": { "chemical_mass": 12941.0, "monoisotopic_mass": 12941.0 }, "refseq": { "ac": "NP_001040046", "name": "protein Churchill", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040046" }, "gene_names": [ { "name": "CHURC1", "type": "recommended", "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ] }, { "name": "CHURC1", "type": "synonym", "evidence": [ { "id": "NP_001040046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040046" } ] } ], "protein_names": [ { "name": "Protein Churchill", "type": "recommended", "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#names_and_taxonomy" } ] }, { "name": "protein Churchill", "type": "synonym", "evidence": [ { "id": "NP_001040046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040046" } ] } ], "function": [ { "annotation": "Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "database": "UniProtKB", "id": "Q5U3N7", "url": "https://www.uniprot.org/uniprotkb/Q5U3N7#function" }, { "database": "UniProtKB", "id": "Q8WUH1", "url": "https://www.uniprot.org/uniprotkb/Q8WUH1#function" }, { "database": "UniProtKB", "id": "Q9DFZ3", "url": "https://www.uniprot.org/uniprotkb/Q9DFZ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHURC1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7", "locus": { "chromosome": "10", "start_pos": 77073623, "end_pos": 77048020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003469", "url": "https://www.ensembl.org/id/ENSBTAG00000003469" } ] } } ], "crossref": [ { "id": "Q2HJG7", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003469", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616539", "url": "https://www.ncbi.nlm.nih.gov/gene/616539", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038543", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038543", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616539", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616539", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZJ7", "url": "https://www.orthodb.org/?gene=A0A3Q1LZJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8K3QSA6", "url": "https://www.orthodb.org/?gene=A0A8K3QSA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2HJG7", "url": "https://www.orthodb.org/?gene=Q2HJG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31931", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31931", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31931:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31931:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06573", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06573", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZJ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8K3QSA6", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8K3QSA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2T1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2T1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T805", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T805-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF", "length": 112, "header": "sp|Q2HJG7-1|CHUR_BOVIN Isoform 1 of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=3 CANONICAL=Q2HJG7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZJ7-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#A0A3Q1LZJ7-1", "sequence": { "sequence": "MRRPSLNSREVSSSRKHRRIFADNGVAMCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQAGIGLQLLKIHRSNSEGEELDSGESHGQTGNPRTHSPVSAPHCLHFQGFRLSYLFPVNYMS", "length": 170, "header": "tr|A0A3Q1LZJ7-1|A0A3Q1LZJ7_BOVIN Computationally mapped isoform of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=1 CANONICAL=Q2HJG7-1" }, "locus": { "chromosome": "10", "start_pos": 77059396, "end_pos": 77048067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062757.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062757.1" } ] } }, { "isoform_ac": "A0A8K3QSA6-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#A0A8K3QSA6-1", "sequence": { "sequence": "MRRPSLNSREVSSSRKHRRIFADNGVAMCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDPDLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF", "length": 140, "header": "tr|A0A8K3QSA6-1|A0A8K3QSA6_BOVIN Computationally mapped isoform of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=2 CANONICAL=Q2HJG7-1" }, "locus": { "chromosome": "10", "start_pos": 77064095, "end_pos": 77048067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035771.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035771.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035640.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035640.5" } ] } }, { "isoform_ac": "A0AAA9S2T1-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#A0AAA9S2T1-1", "sequence": { "sequence": "MCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQHKIKGTLGRMLCDFNNGFWCFSLHQSEEVRLCLS", "length": 116, "header": "tr|A0AAA9S2T1-1|A0AAA9S2T1_BOVIN Computationally mapped isoform of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=1 CANONICAL=Q2HJG7-1" }, "locus": { "chromosome": "10", "start_pos": 77073620, "end_pos": 77048148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123575.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123575.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076414.1" } ] } }, { "isoform_ac": "A0AAA9T805-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#A0AAA9T805-1", "sequence": { "sequence": "MCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDPNQRDPW", "length": 65, "header": "tr|A0AAA9T805-1|A0AAA9T805_BOVIN Computationally mapped isoform of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=1 CANONICAL=Q2HJG7-1" }, "locus": { "chromosome": "10", "start_pos": 77073536, "end_pos": 77048148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134926.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134926.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092922.1" } ] } }, { "isoform_ac": "Q2HJG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7/entry#Q2HJG7-1", "sequence": { "sequence": "MCVDCVEKEYPNRGNICLESGSFLLNFTGCAVCNKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF", "length": 112, "header": "sp|Q2HJG7-1|CHUR_BOVIN Isoform 1 of Protein Churchill OS=Bos taurus OX=9913 GN=CHURC1 PE=3 SV=3 CANONICAL=Q2HJG7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616539", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616539", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6DG52-1", "protein_name": "Protein Churchill", "gene_name": "Churc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCGDCVEKEYPNRGTTCLENGSFLLNFAGCAVCSKRDFMLITNRSLKEEDGEEIVTYDHLCKNCHHVVARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF", "length": 112 }, "evidence": [ { "id": "Q2HJG7", "url": "https://omabrowser.org/oma/group/Q2HJG7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9DFZ3-1", "protein_name": "Protein Churchill", "gene_name": "CHURC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCGGCVGTEYPERGTTCLEGGSFLLNFVGCARCGRRDFVLLGNRAAGLHGDDEIITYDHLCKNCHHLIARHEYTFSVVDDYQEYTMLCLLCGRAEDSVSILPDDPRQMTPLF", "length": 112 }, "evidence": [ { "id": "Q2HJG7", "url": "https://omabrowser.org/oma/group/Q2HJG7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 112, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJG7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805#function" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805" } ], "binding_site_uniprot": 2, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2, "end_pos": 2, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" } ], "binding_site_uniprot": 29, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 29, "end_pos": 29, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805#function" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805" } ], "binding_site_uniprot": 30, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 30, "end_pos": 30, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" } ], "binding_site_uniprot": 32, "amino_acid": "Val", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 32, "end_pos": 32, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805#function" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805" } ], "binding_site_uniprot": 33, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 33, "end_pos": 33, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805#function" }, { "id": "A0AAA9T805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T805" } ], "binding_site_uniprot": 5, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 5, "end_pos": 5, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" } ], "binding_site_uniprot": 57, "amino_acid": "Tyr", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 57, "end_pos": 57, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 59, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 59, "end_pos": 59, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" } ], "binding_site_uniprot": 60, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 60, "end_pos": 60, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 61, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 61, "end_pos": 61, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 64, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 64, "end_pos": 64, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 66, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 66, "end_pos": 66, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 71, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 71, "end_pos": 71, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 86, "amino_acid": "Met", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 86, "end_pos": 86, "start_aa": "Met", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "binding_site_uniprot": 88, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 88, "end_pos": 88, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 89, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 89, "end_pos": 89, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7#function" }, { "id": "Q2HJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG7" } ], "binding_site_uniprot": 91, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 91, "end_pos": 91, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 92, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 92, "end_pos": 92, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 93, "amino_acid": "Lys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 93, "end_pos": 93, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1#function" }, { "id": "A0AAA9S2T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T1" } ], "binding_site_uniprot": 94, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 94, "end_pos": 94, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7#function" }, { "id": "A0A3Q1LZJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ7" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 98, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 98, "end_pos": 98, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6#function" }, { "id": "A0A8K3QSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8K3QSA6" }, { "id": "PIRSR609508-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609508-1" } ], "binding_site_uniprot": 99, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 99, "end_pos": 99, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 26, "end_pos": 28 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJG8-1", "uniprot_ac": "Q2HJG8", "uniprot_id": "TAF7_BOVIN", "mass": { "chemical_mass": 40268.0, "monoisotopic_mass": 40268.0 }, "refseq": { "ac": "NP_001039493", "name": "transcription initiation factor TFIID subunit 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493" }, "gene_names": [ { "name": "TAF7", "type": "recommended", "evidence": [ { "id": "Q2HJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ] }, { "name": "TAF7", "type": "synonym", "evidence": [ { "id": "NP_001039493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493" } ] } ], "protein_names": [ { "name": "Transcription initiation factor TFIID subunit 7", "type": "recommended", "evidence": [ { "id": "Q2HJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8/entry#names_and_taxonomy" } ] }, { "name": "TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa", "type": "synonym", "evidence": [ { "id": "NP_001039493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493" } ] }, { "name": "TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa", "type": "synonym", "evidence": [ { "id": "NP_001039493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493" } ] }, { "name": "transcription initiation factor TFIID subunit 7", "type": "synonym", "evidence": [ { "id": "NP_001039493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493" } ] } ], "function": [ { "annotation": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8#function" }, { "database": "UniProtKB", "id": "Q15545", "url": "https://www.uniprot.org/uniprotkb/Q15545#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAF7", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8", "locus": { "chromosome": "7", "start_pos": 52393852, "end_pos": 52400994, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000070085", "url": "https://www.ensembl.org/id/ENSBTAG00000070085" } ] } } ], "crossref": [ { "id": "Q2HJG8", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08047", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08047", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509327", "url": "https://www.ncbi.nlm.nih.gov/gene/509327", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509327", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509327", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJG8", "url": "https://www.orthodb.org/?gene=Q2HJG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12228:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12228:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04658", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04658", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039493", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJG8-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLSIELHPDGRHGIVRVDRVPLAAKLVDLPRVMESLKTIDKKTFYKTADVCQMLVSTVDGDLYPPVEEPVATADPKASKKKDKDKEKKFVWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKETENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK", "length": 349, "header": "sp|Q2HJG8-1|TAF7_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 7 OS=Bos taurus OX=9913 GN=TAF7 PE=2 SV=1 CANONICAL=Q2HJG8-1" }, "isoforms": [ { "isoform_ac": "Q2HJG8-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8/entry#Q2HJG8-1", "sequence": { "sequence": "MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLSIELHPDGRHGIVRVDRVPLAAKLVDLPRVMESLKTIDKKTFYKTADVCQMLVSTVDGDLYPPVEEPVATADPKASKKKDKDKEKKFVWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKETENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK", "length": 349, "header": "sp|Q2HJG8-1|TAF7_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 7 OS=Bos taurus OX=9913 GN=TAF7 PE=2 SV=1 CANONICAL=Q2HJG8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "site_lbl": "Ser171" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "site_lbl": "Ser200" }, { "start_pos": 201, "end_pos": 201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "site_lbl": "Ser201" }, { "start_pos": 213, "end_pos": 213, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "site_lbl": "Ser213" }, { "start_pos": 264, "end_pos": 264, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "site_lbl": "Ser264" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509327", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509327", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "pmid": "" }, { "name": "RNA polymerase II preinitiation complex assembly", "id": "GO:0051123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "pmid": "" }, { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "Q2HJG8", "url": "https://www.uniprot.org/uniprotkb/Q2HJG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJG8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJG8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJG8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 171, 200, 201, 213, 264 ], "sequon_annotation_sites": [ { "start_pos": 262, "end_pos": 264 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJH6-1", "uniprot_ac": "Q2HJH6", "uniprot_id": "SNR40_BOVIN", "mass": { "chemical_mass": 39380.0, "monoisotopic_mass": 39380.0 }, "refseq": { "ac": "NP_001039847", "name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" }, "gene_names": [ { "name": "SNRNP40", "type": "recommended", "evidence": [ { "id": "Q2HJH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ] }, { "name": "SNRNP40", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" } ] }, { "name": "WDR57", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" }, { "id": "Q2HJH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ] } ], "protein_names": [ { "name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "type": "recommended", "evidence": [ { "id": "Q2HJH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6/entry#names_and_taxonomy" } ] }, { "name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" } ] }, { "name": "U5 snRNP 40 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" }, { "id": "Q2HJH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6/entry#names_and_taxonomy" } ] }, { "name": "WD repeat domain 57 (U5 snRNP specific)", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" } ] }, { "name": "WD repeat-containing protein 57", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" }, { "id": "Q2HJH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6/entry#names_and_taxonomy" } ] }, { "name": "small nuclear ribonucleoprotein 40kDa (U5)", "type": "synonym", "evidence": [ { "id": "NP_001039847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847" } ] } ], "function": [ { "annotation": "Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6#function" }, { "database": "UniProtKB", "id": "Q96DI7", "url": "https://www.uniprot.org/uniprotkb/Q96DI7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP40", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6", "locus": { "chromosome": "2", "start_pos": 122372981, "end_pos": 122347180, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016817", "url": "https://www.ensembl.org/id/ENSBTAG00000016817" } ] } } ], "crossref": [ { "id": "Q2HJH6", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534645", "url": "https://www.ncbi.nlm.nih.gov/gene/534645", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534645", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534645", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJH6", "url": "https://www.orthodb.org/?gene=Q2HJH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44006:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039847", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVRIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358, "header": "sp|Q2HJH6-1|SNR40_BOVIN Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein OS=Bos taurus OX=9913 GN=SNRNP40 PE=2 SV=1 CANONICAL=Q2HJH6-1" }, "isoforms": [ { "isoform_ac": "Q2HJH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6/entry#Q2HJH6-1", "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVRIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358, "header": "sp|Q2HJH6-1|SNR40_BOVIN Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein OS=Bos taurus OX=9913 GN=SNRNP40 PE=2 SV=1 CANONICAL=Q2HJH6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534645", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534645", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA splicing, via transesterification reactions", "id": "GO:0000375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000375", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ], "pmid": "" }, { "name": "U5 snRNP", "id": "GO:0005682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005682", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH6", "url": "https://www.uniprot.org/uniprotkb/Q2HJH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJH6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJH7-1", "uniprot_ac": "Q2HJH7", "uniprot_id": "MEMO1_BOVIN", "mass": { "chemical_mass": 32525.0, "monoisotopic_mass": 32525.0 }, "refseq": { "ac": "NP_001069863", "name": "protein MEMO1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" }, "gene_names": [ { "name": "MEMO1", "type": "recommended", "evidence": [ { "id": "Q2HJH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7" } ] }, { "name": "MEMO1", "type": "synonym", "evidence": [ { "id": "NP_001069863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" } ] } ], "protein_names": [ { "name": "Protein MEMO1", "type": "recommended", "evidence": [ { "id": "Q2HJH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7/entry#names_and_taxonomy" } ] }, { "name": "Mediator of ErbB2-driven cell motility 1", "type": "synonym", "evidence": [ { "id": "Q2HJH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7/entry#names_and_taxonomy" } ] }, { "name": "Memo-1", "type": "synonym", "evidence": [ { "id": "Q2HJH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7/entry#names_and_taxonomy" } ] }, { "name": "mediator of ErbB2-driven cell motility 1", "type": "synonym", "evidence": [ { "id": "NP_001069863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" } ] }, { "name": "memo-1", "type": "synonym", "evidence": [ { "id": "NP_001069863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" } ] }, { "name": "protein MEMO1", "type": "synonym", "evidence": [ { "id": "NP_001069863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" } ] }, { "name": "protein memo", "type": "synonym", "evidence": [ { "id": "NP_001069863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863" } ] } ], "function": [ { "annotation": "May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH7", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJH7", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEMO1", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7", "locus": { "chromosome": "11", "start_pos": 14544697, "end_pos": 14656265, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007734", "url": "https://www.ensembl.org/id/ENSBTAG00000007734" } ] } } ], "crossref": [ { "id": "Q2HJH7", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07361", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07361", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615803", "url": "https://www.ncbi.nlm.nih.gov/gene/615803", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615803", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615803", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJH7", "url": "https://www.orthodb.org/?gene=Q2HJH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11060:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11060:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069863", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJH7", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJH7-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFFQQASWRRRMGAAAV", "length": 285, "header": "sp|Q2HJH7-1|MEMO1_BOVIN Isoform 1 of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=2 SV=1 CANONICAL=Q2HJH7-1" }, "isoforms": [ { "isoform_ac": "Q2HJH7-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7/entry#Q2HJH7-1", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFFQQASWRRRMGAAAV", "length": 285, "header": "sp|Q2HJH7-1|MEMO1_BOVIN Isoform 1 of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=2 SV=1 CANONICAL=Q2HJH7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH7", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7" } ], "site_lbl": "Tyr210" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615803", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615803", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of microtubule-based process", "id": "GO:0032886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032886", "evidence": [ { "database": "UniProtKB", "id": "Q2HJH7", "url": "https://www.uniprot.org/uniprotkb/Q2HJH7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJH7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 285, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJH7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJH7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 210 ], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJI0-1", "uniprot_ac": "Q2HJI0", "uniprot_id": "RM19_BOVIN", "mass": { "chemical_mass": 33335.0, "monoisotopic_mass": 33335.0 }, "refseq": { "ac": "NP_001039533", "name": "large ribosomal subunit protein bL19m", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" }, "gene_names": [ { "name": "MRPL19", "type": "recommended", "evidence": [ { "id": "Q2HJI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ] }, { "name": "MRPL19", "type": "synonym", "evidence": [ { "id": "NP_001039533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein bL19m", "type": "recommended", "evidence": [ { "id": "Q2HJI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L19, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001039533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" }, { "id": "Q2HJI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0/entry#names_and_taxonomy" } ] }, { "name": "L19mt", "type": "synonym", "evidence": [ { "id": "NP_001039533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" }, { "id": "Q2HJI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0/entry#names_and_taxonomy" } ] }, { "name": "MRP-L19", "type": "synonym", "evidence": [ { "id": "NP_001039533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" }, { "id": "Q2HJI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein bL19m", "type": "synonym", "evidence": [ { "id": "NP_001039533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL19", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0", "locus": { "chromosome": "11", "start_pos": 44019420, "end_pos": 44030088, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002557", "url": "https://www.ensembl.org/id/ENSBTAG00000002557" } ] } } ], "crossref": [ { "id": "Q2HJI0", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJI0", "database": "AlphaFoldDB", "categories": [] }, { "id": "510957", "url": "https://www.ncbi.nlm.nih.gov/gene/510957", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2FTC", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2FTC&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510957", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510957", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2HJI0", "url": "https://www.orthodb.org/?gene=Q2HJI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15680", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15680", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15680:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15680:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00002ftc", "url": "https://www.rcsb.org/structure/pdb_00002ftc", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2FTC", "url": "https://www.rcsb.org/structure/2FTC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01245", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01245", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASIARGCQAAKGLGPSFRSARALLPVSTSVASRVLAGPGRRQITGPSEPGVFQPPPKPVIVDKRGPQRRESRFLSPEFIPPRGRTNPLKFQIERKDMLERRKILHIPEFYVGSILRVTTADPYANGKTSQFLGICIQRSGKGLGATFILRNTIEGQGVEICFELYNPRIQEIQVVKLEKRLDDSLLYLRDALPEYSTFDMNMKPVAQEPSREVPINQLKVKMKPKPWSKRWERPKFNVKGIRFDLCLTEEQMKEAQKWSQPWLEFDMMREYDTSKIETAIWNEIEASKSS", "length": 292, "header": "sp|Q2HJI0-1|RM19_BOVIN Isoform 1 of Large ribosomal subunit protein bL19m OS=Bos taurus OX=9913 GN=MRPL19 PE=1 SV=1 CANONICAL=Q2HJI0-1" }, "isoforms": [ { "isoform_ac": "Q2HJI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0/entry#Q2HJI0-1", "sequence": { "sequence": "MAASIARGCQAAKGLGPSFRSARALLPVSTSVASRVLAGPGRRQITGPSEPGVFQPPPKPVIVDKRGPQRRESRFLSPEFIPPRGRTNPLKFQIERKDMLERRKILHIPEFYVGSILRVTTADPYANGKTSQFLGICIQRSGKGLGATFILRNTIEGQGVEICFELYNPRIQEIQVVKLEKRLDDSLLYLRDALPEYSTFDMNMKPVAQEPSREVPINQLKVKMKPKPWSKRWERPKFNVKGIRFDLCLTEEQMKEAQKWSQPWLEFDMMREYDTSKIETAIWNEIEASKSS", "length": 292, "header": "sp|Q2HJI0-1|RM19_BOVIN Isoform 1 of Large ribosomal subunit protein bL19m OS=Bos taurus OX=9913 GN=MRPL19 PE=1 SV=1 CANONICAL=Q2HJI0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "site_lbl": "Ser77" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:510957", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510957", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI0", "url": "https://www.uniprot.org/uniprotkb/Q2HJI0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJI0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJI0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJI0" }, { "pdb_id": "2ftc", "pdb_chain": "k", "start_pos": 108, "end_pos": 205, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/2ftc.pdb", "url_external": "https://www.rcsb.org/structure/2ftc" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 77 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2HJI2-1", "uniprot_ac": "Q2HJI2", "uniprot_id": "NDUF3_BOVIN", "mass": { "chemical_mass": 20477.0, "monoisotopic_mass": 20477.0 }, "refseq": { "ac": "NP_001039570", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" }, "gene_names": [ { "name": "NDUFAF3", "type": "recommended", "evidence": [ { "id": "Q2HJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2" } ] }, { "name": "C22H3orf60", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] }, { "name": "C3orf60", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] }, { "name": "NDUFAF3", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "type": "recommended", "evidence": [ { "id": "Q2HJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] }, { "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 3", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] }, { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "type": "synonym", "evidence": [ { "id": "NP_001039570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570" } ] } ], "function": [ { "annotation": "Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFAF3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2", "locus": { "chromosome": "22", "start_pos": 50968278, "end_pos": 50969630, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018918", "url": "https://www.ensembl.org/id/ENSBTAG00000018918" } ] } } ], "crossref": [ { "id": "Q2HJI2", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05125", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05125", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511968", "url": "https://www.ncbi.nlm.nih.gov/gene/511968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511968", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511968", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FSKAYDH", "url": "https://omabrowser.org/oma/group/FSKAYDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJI2", "url": "https://www.orthodb.org/?gene=Q2HJI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21192:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21192:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04430", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04430", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039570", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJI2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAFVLRNLYRARPALRSPPSELPWAPRRGHRLTPADDELYQRTRISLLQRESPLAMYIDSYSSRGFVVNGNRVFGPCALLPQSVVQWNVGSYQDITEESFSLFWMLEPRIEIVVVGTGDRTERLQPHVLRAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTALTSQAQAAE", "length": 184, "header": "sp|Q2HJI2-1|NDUF3_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Bos taurus OX=9913 GN=NDUFAF3 PE=2 SV=1 CANONICAL=Q2HJI2-1" }, "isoforms": [ { "isoform_ac": "Q2HJI2-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2/entry#Q2HJI2-1", "sequence": { "sequence": "MAAAFVLRNLYRARPALRSPPSELPWAPRRGHRLTPADDELYQRTRISLLQRESPLAMYIDSYSSRGFVVNGNRVFGPCALLPQSVVQWNVGSYQDITEESFSLFWMLEPRIEIVVVGTGDRTERLQPHVLRAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTALTSQAQAAE", "length": 184, "header": "sp|Q2HJI2-1|NDUF3_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Bos taurus OX=9913 GN=NDUFAF3 PE=2 SV=1 CANONICAL=Q2HJI2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511968", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511968", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L1F1-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "ndufaf3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAVRHLCQRTAIRLRLTCSPQSRVCVVRGHRLGPFDDEQYRKTSVSIMQKEASAGTVIYSYSPRGFNINGNTVFGPCAVLPPAILQWNVGSHSDISVESLSLFYLLEPQIEVLVLGTGARTERLHAEVLEELKKRGIAVEVQDTPNACATFNFLSSEKRLAAAALIPPPAGSR", "length": 174 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SKI6-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "NDUFAF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVFVLRSLYRARHILRWPLAQLSWAPGRGHRLTPTDDELYQRTRISLLQRESPQAMYIDSYSSRGFVVNGNRVLGPCALLPHSVVQWNVGSHQDITEGSFSLFWMLEPRIEIVVVGTGDRTERLQPQVLRAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGAALTSLAQVSKK", "length": 185 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08776-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "Ndufaf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATALGFRCLYRTRPATLGRYVDRLWRSPSRGHRLSPADDELYQRTRISLLQNEFPQAVYIDSYNSRGFTINGNRVFGPCALLPQTVVQWNVGSHQDITEESFSIFWMLEPRIEIVVVGTGNKTERLHSQVLQAMRQRGIAVEIQDTPNACATFNFLCHEGRVTGAALIPPPGETALASSGQTTE", "length": 185 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8RUX8-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAMRLKSMATLPKLIQSMRKEVPKHSNPVLPSLRRAFSLYDQINLIDNVPEDQLRFQEFNDTSFTVNGVKYEGSLLCVGNLLMSWSPRKFSEITTDSLSIFQTVRPIPELLIVGCGRDIHPVTPEVRQFVKSLGMKLETVDSRNAASTYNILNEEGRVVAAALLPYGVTS", "length": 170 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BU61-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "NDUFAF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATALALRSLYRARPSLRCPPVELPWAPRRGHRLSPADDELYQRTRISLLQREAAQAMYIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWLLEPRIEIVVVGTGDRTERLQSQVLQAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTSLTSLGQAAQ", "length": 184 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JKL4-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "Ndufaf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATALGFRCLFRTRPAPLCRHVDRLWRNPRRGHRLSPADDELYQRTRISLLQSEFPQAVYIDSYSSRGFTICGNRVFGPCVLLPQTVVQWNVGSHQDITEESFSLFWMLEPRIEIVVVGTGNKTERLHPQVLQAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGETALASLGQASE", "length": 185 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W1H9-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "NdufAF3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIARTLRTVGRQGRNLLLPRITACRPLHAIPANFSKAYDHDGKTKVTIFNTETDLGLMVTGYSQYGFRLNNDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPPALSKRIIEFMKKYKINVEILRTEQACATFNFLNAENRMVACALIPPLHLSYNENDILQAKLRKKELYETE", "length": 196 }, "evidence": [ { "id": "Q2HJI2", "url": "https://omabrowser.org/oma/group/Q2HJI2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI2", "url": "https://www.uniprot.org/uniprotkb/Q2HJI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJI2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJI2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2HJI3-1", "uniprot_ac": "Q2HJI3", "uniprot_id": "TIMCC_BOVIN", "mass": { "chemical_mass": 15683.0, "monoisotopic_mass": 15683.0 }, "refseq": { "ac": "NP_001040053", "name": "protein FAM136A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053" }, "gene_names": [ { "name": "TIMCC", "type": "recommended", "evidence": [ { "id": "Q2HJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ] }, { "name": "FAM136A", "type": "synonym", "evidence": [ { "id": "NP_001040053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053" }, { "id": "Q2HJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ] }, { "name": "TIMCC", "type": "synonym", "evidence": [ { "id": "NP_001040053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053" } ] } ], "protein_names": [ { "name": "TIM double twin CX3C motif protein", "type": "recommended", "evidence": [ { "id": "Q2HJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 136 member A", "type": "synonym", "evidence": [ { "id": "NP_001040053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053" } ] }, { "name": "protein FAM136A", "type": "synonym", "evidence": [ { "id": "NP_001040053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053" } ] } ], "function": [ { "annotation": "Plays a role in proteostasis of the mitochondrion intermembrane space and counteracts aggregation of certain proteins. Required for mitochondrial oxidative phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3#function" }, { "database": "UniProtKB", "id": "Q96C01", "url": "https://www.uniprot.org/uniprotkb/Q96C01#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMCC", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3", "locus": {} } ], "crossref": [ { "id": "Q2HJI3", "url": "https://alphafold.ebi.ac.uk/entry/Q2HJI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008674", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616997", "url": "https://www.ncbi.nlm.nih.gov/gene/616997", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616997", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616997", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EMEGCVV", "url": "https://omabrowser.org/oma/group/EMEGCVV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2HJI3", "url": "https://www.orthodb.org/?gene=Q2HJI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21096", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21096", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21096:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21096:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040053", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2HJI3-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELQQLRVQEAVDSMVKSLERENIRKMQGLMFRCSAACCEESQASMQQVHQCIERCHAPLAQAQALVTSELEKFQDRLARCTMYCNDKAKDSIDAGSKELHVKRQLETCVTKCVDDHMNLIPTMTRKMKESLSSIGK", "length": 138, "header": "sp|Q2HJI3-1|TIMCC_BOVIN Isoform 1 of TIM double twin CX3C motif protein OS=Bos taurus OX=9913 GN=TIMCC PE=2 SV=1 CANONICAL=Q2HJI3-1" }, "isoforms": [ { "isoform_ac": "Q2HJI3-1", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3/entry#Q2HJI3-1", "sequence": { "sequence": "MAELQQLRVQEAVDSMVKSLERENIRKMQGLMFRCSAACCEESQASMQQVHQCIERCHAPLAQAQALVTSELEKFQDRLARCTMYCNDKAKDSIDAGSKELHVKRQLETCVTKCVDDHMNLIPTMTRKMKESLSSIGK", "length": 138, "header": "sp|Q2HJI3-1|TIMCC_BOVIN Isoform 1 of TIM double twin CX3C motif protein OS=Bos taurus OX=9913 GN=TIMCC PE=2 SV=1 CANONICAL=Q2HJI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "site_lbl": "Thr124" }, { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "site_lbl": "Thr126" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616997", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616997", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B0BN94-1", "protein_name": "TIM double twin CX3C motif protein", "gene_name": "Timcc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEVQQLRVQEAVDAMVKSVERENIRKMQGLMFRCSANCCEDNQASMQQVHQCIERCHAPLAQAQALVTSELERFQDRLARCTMHCNDKAKDSMDAGSKELQVKRQLDSCVAKCVDDHMHLIPTMTKKIKESLSSIGK", "length": 138 }, "evidence": [ { "id": "Q2HJI3", "url": "https://omabrowser.org/oma/group/Q2HJI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8RV68-1", "protein_name": "FAM136A-like protein (DUF842)", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDHIAAAEEQIVSERLRRKLEEVNVAAQTQLSPIQDHINFTLQQAYFKCAYECFDRRRKQEEISNCVEHCSVPVVKSQQYFENEMAQFQERLNRSLVVCQDKFEASKLQKIRPEAVNEMESCVHKSIEENLNTLPHIVQRMKTAFNITN", "length": 149 }, "evidence": [ { "id": "Q2HJI3", "url": "https://omabrowser.org/oma/group/Q2HJI3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CR98-1", "protein_name": "TIM double twin CX3C motif protein", "gene_name": "Timcc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEVQQLRVQEAVDAMVKSVERENIRKMQGLMFRCSANCCEDTQASMQQVHQCIERCHAPLAQAQALVTSELERFQDRLARCTMHCNDKAKDSMDAGTKELQVKRQLDSCVTKCVDDHMHLIPTMTKKMKESLSSIGK", "length": 138 }, "evidence": [ { "id": "Q2HJI3", "url": "https://omabrowser.org/oma/group/Q2HJI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2HJI3", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2HJI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 138, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2HJI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2HJI3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2HJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Twin CX3C motif 1", "eco_id": "ECO_0000250", "start_pos": 35, "end_pos": 57, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2HJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Twin CX3C motif 2", "eco_id": "ECO_0000250", "start_pos": 82, "end_pos": 114, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 124, 126 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHT6-1", "uniprot_ac": "Q2KHT6", "uniprot_id": "FBX32_BOVIN", "mass": { "chemical_mass": 41595.0, "monoisotopic_mass": 41595.0 }, "refseq": { "ac": "NP_001039620", "name": "F-box only protein 32", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620" }, "gene_names": [ { "name": "FBXO32", "type": "recommended", "evidence": [ { "id": "Q2KHT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ] }, { "name": "FBXO32", "type": "synonym", "evidence": [ { "id": "NP_001039620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620" } ] } ], "protein_names": [ { "name": "F-box only protein 32", "type": "recommended", "evidence": [ { "id": "Q2KHT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 32", "type": "synonym", "evidence": [ { "id": "NP_001039620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620" } ] } ], "function": [ { "annotation": "A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.", "evidence": [ { "database": "RefSeq", "id": "NP_001039620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620" }, { "database": "PubMed", "id": "23232357", "url": "https://glygen.org/publication/PubMed/23232357" } ] }, { "annotation": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Negatively regulates macrophage efferocytosis by promoting the ubiquitination of the transcription factor KLF4, suppressing the receptor tyrosine kinase MERTK transcription. Regulates LPS-induced apoptosis and mitochondrial dysfunction through ANXA1 ubiquitination and degradation. Mediates cyclin D1 protein stabilization via 'Lys-27'-linked ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "A0ABI0NQQ9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ9#function" }, { "database": "UniProtKB", "id": "ARBA00094226", "url": "https://www.uniprot.org/uniprotkb/ARBA00094226#function" }, { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6#function" }, { "database": "UniProtKB", "id": "Q969P5", "url": "https://www.uniprot.org/uniprotkb/Q969P5#function" }, { "database": "UniProtKB", "id": "Q9CPU7", "url": "https://www.uniprot.org/uniprotkb/Q9CPU7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO32", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6", "locus": { "chromosome": "14", "start_pos": 16361047, "end_pos": 16328949, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016194", "url": "https://www.ensembl.org/id/ENSBTAG00000016194" } ] } } ], "crossref": [ { "id": "Q2KHT6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016194", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016194", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22103", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22103", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513776", "url": "https://www.ncbi.nlm.nih.gov/gene/513776", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513776", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513776", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NINTWVH", "url": "https://omabrowser.org/oma/group/NINTWVH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHT6", "url": "https://www.orthodb.org/?gene=Q2KHT6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13123:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13123:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27576", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27576", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NQQ9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHT6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLGSYCSKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQVAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLARCYPRKEQYGDTLQLCRHCHILSWKGTDHPCTANNPESCSISLSPQDFINLFKF", "length": 355, "header": "sp|Q2KHT6-1|FBX32_BOVIN Isoform 1 of F-box only protein 32 OS=Bos taurus OX=9913 GN=FBXO32 PE=2 SV=1 CANONICAL=Q2KHT6-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NQQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6/entry#A0ABI0NQQ9-1", "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLGSYCSKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQVAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLARCYPRKEQYGDTLQLCRHCHILSWKGTDHPCTANNPESCSISLSPQDFINLFKF", "length": 262, "header": "tr|A0ABI0NQQ9-1|A0ABI0NQQ9_BOVIN Computationally mapped isoform of F-box only protein 32 OS=Bos taurus OX=9913 GN=FBXO32 PE=4 SV=1 CANONICAL=Q2KHT6-1" }, "locus": { "chromosome": "14", "start_pos": 16360638, "end_pos": 16328967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136665.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136665.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104625.1" } ] } }, { "isoform_ac": "Q2KHT6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6/entry#Q2KHT6-1", "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLGSYCSKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQVAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLARCYPRKEQYGDTLQLCRHCHILSWKGTDHPCTANNPESCSISLSPQDFINLFKF", "length": 355, "header": "sp|Q2KHT6-1|FBX32_BOVIN Isoform 1 of F-box only protein 32 OS=Bos taurus OX=9913 GN=FBXO32 PE=2 SV=1 CANONICAL=Q2KHT6-1" }, "locus": { "chromosome": "14", "start_pos": 16360638, "end_pos": 16328967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106814.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106814.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "SNP identification in FBXO32 gene and their associations with growth traits in cattle.", "journal": "Gene", "date": "2013-02-15", "authors": "Wang Ailan, Zhang Ya, Li Mijie, Lan Xianyong, Wang Juqiang, Chen Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001039620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039620" } ], "reference": [ { "type": "PubMed", "id": "23232357", "url": "https://glygen.org/publication/PubMed/23232357" } ] } ], "pathway": [ { "id": "bta:513776", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513776", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q1A730-1", "protein_name": "F-box only protein 32", "gene_name": "FBXO32", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQVAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCRHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF", "length": 355 }, "evidence": [ { "id": "Q2KHT6", "url": "https://omabrowser.org/oma/group/Q2KHT6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q91Z62-1", "protein_name": "F-box only protein 32", "gene_name": "Fbxo32", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGTFVSDLSSYCNKENLFNSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETTLHWQQQLNSIQISRPAFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF", "length": 350 }, "evidence": [ { "id": "Q2KHT6", "url": "https://omabrowser.org/oma/group/Q2KHT6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q969P5-1", "protein_name": "F-box only protein 32", "gene_name": "FBXO32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF", "length": 355 }, "evidence": [ { "id": "Q2KHT6", "url": "https://omabrowser.org/oma/group/Q2KHT6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CPU7-1", "protein_name": "F-box only protein 32", "gene_name": "Fbxo32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYSKENLFSSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNSIQISRPAFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF", "length": 355 }, "evidence": [ { "id": "Q2KHT6", "url": "https://omabrowser.org/oma/group/Q2KHT6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "pmid": "" }, { "name": "response to denervation involved in regulation of muscle adaptation", "id": "GO:0014894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014894", "evidence": [ { "database": "UniProtKB", "id": "Q2KHT6", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHT6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 355, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHT6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHT6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KHT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Bipartite nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 280, "end_pos": 295, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KHT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear export signal", "eco_id": "ECO_0000250", "start_pos": 169, "end_pos": 173, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KHT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHT6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 62, "end_pos": 67, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KHU9-1", "uniprot_ac": "Q2KHU9", "uniprot_id": "HSPB3_BOVIN", "mass": { "chemical_mass": 16722.0, "monoisotopic_mass": 16722.0 }, "refseq": { "ac": "NP_001040035", "name": "heat shock protein beta-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040035" }, "gene_names": [ { "name": "HSPB3", "type": "recommended", "evidence": [ { "id": "Q2KHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" } ] }, { "name": "HSPB3", "type": "synonym", "evidence": [ { "id": "NP_001040035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040035" } ] } ], "protein_names": [ { "name": "Heat shock protein beta-3", "type": "recommended", "evidence": [ { "id": "Q2KHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9/entry#names_and_taxonomy" } ] }, { "name": "HspB3", "type": "synonym", "evidence": [ { "id": "Q2KHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9/entry#names_and_taxonomy" } ] }, { "name": "heat shock 27kDa protein 3", "type": "synonym", "evidence": [ { "id": "NP_001040035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040035" } ] }, { "name": "heat shock protein beta-3", "type": "synonym", "evidence": [ { "id": "NP_001040035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040035" } ] } ], "function": [ { "annotation": "Inhibitor of actin polymerization.", "evidence": [ { "database": "UniProtKB", "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPB3", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9", "locus": { "chromosome": "20", "start_pos": 24638190, "end_pos": 24638869, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022714", "url": "https://www.ensembl.org/id/ENSBTAG00000022714" } ] } } ], "crossref": [ { "id": "Q2KHU9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022714", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022714", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06477", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06477", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616007", "url": "https://www.ncbi.nlm.nih.gov/gene/616007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGPRMDE", "url": "https://omabrowser.org/oma/group/HGPRMDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHU9", "url": "https://www.orthodb.org/?gene=Q2KHU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47097:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47097:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040035", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHU9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKIILRHLIETPVRYEQEFEARGLEDCRLDHALYALPGPTTVDLGKARAAQAPPVDAAEMPPQRGESRFQVLLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGIETKDLSAILCHDGILVVEVKDSAGTK", "length": 149, "header": "sp|Q2KHU9-1|HSPB3_BOVIN Isoform 1 of Heat shock protein beta-3 OS=Bos taurus OX=9913 GN=HSPB3 PE=2 SV=1 CANONICAL=Q2KHU9-1" }, "isoforms": [ { "isoform_ac": "Q2KHU9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9/entry#Q2KHU9-1", "sequence": { "sequence": "MAKIILRHLIETPVRYEQEFEARGLEDCRLDHALYALPGPTTVDLGKARAAQAPPVDAAEMPPQRGESRFQVLLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGIETKDLSAILCHDGILVVEVKDSAGTK", "length": 149, "header": "sp|Q2KHU9-1|HSPB3_BOVIN Isoform 1 of Heat shock protein beta-3 OS=Bos taurus OX=9913 GN=HSPB3 PE=2 SV=1 CANONICAL=Q2KHU9-1" }, "locus": { "chromosome": "20", "start_pos": 24638728, "end_pos": 24638282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030821.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030821.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030791.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030791.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616007", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2TSR2-1", "protein_name": "Heat shock protein family B (small) member 3", "gene_name": "HSPB3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEAVIRHWVETPVRYQEQFAAEELEEHKLNHSLYALPGPFTAALSRRGQILESTDGAEATSQEEEKTGFQVLLDVVQFRPEDIIIQTFEGWLLIKAQHGPRMDEHGFISRSFTRQYKLPDGVENKDLSALFCHDGILVVEMKNSVGIN", "length": 149 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1SMX6-1", "protein_name": "Heat shock protein beta-3", "gene_name": "HSPB3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKIILRHLIETPVRYEEEFEARGLEDCRLDHALYALPGPTTLDLGKARATQAPPVDSAAEGPPQKGECRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGIETKDLSATLCHDGILVVEVKDPVGTK", "length": 150 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HVF1-1", "protein_name": "Heat shock protein beta-3", "gene_name": "Hspb3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKIILRHLIETPVRYQEEFEARGLEDCRLDHALYALPGPTIEDLRKVRGTPQALAEDSASTSTPPGEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVETKDLSAILCHDGILVVEVKDPLATK", "length": 152 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12988-1", "protein_name": "Heat shock protein beta-3", "gene_name": "HSPB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK", "length": 150 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZ57-1", "protein_name": "Heat shock protein beta-3", "gene_name": "Hspb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKIILRHLIETPVRYQEEFEARGLEDCRLDHTLYALPGPTIEDLSKARGAGTPQALAEDSASTEKPPGEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVETKDLSAILCHDGILVVEVKDSLGTK", "length": 154 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QZ58-1", "protein_name": "Heat shock protein beta-3", "gene_name": "Hspb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKIILRHLIETPVRYQEEFEARGLEDCRLDHALYALPGPTIEDLRKARGTPKALAEDSDSAETPPGEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVETKDLSAILCHDGILVVEVKDPLETK", "length": 152 }, "evidence": [ { "id": "Q2KHU9", "url": "https://omabrowser.org/oma/group/Q2KHU9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2KHU9", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHU9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 149, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHU9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHU9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU9" }, { "id": "PRU00285", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00285" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "sHSP", "eco_id": "ECO_0000255", "start_pos": 47, "end_pos": 149, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHV9-1", "uniprot_ac": "Q2KHV9", "uniprot_id": "K2013_BOVIN", "mass": { "chemical_mass": 69587.0, "monoisotopic_mass": 69587.0 }, "refseq": { "ac": "NP_001039407", "name": "uncharacterized protein KIAA2013 homolog precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039407" }, "gene_names": [ { "name": "KIAA2013", "type": "synonym", "evidence": [ { "id": "NP_001039407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039407" } ] } ], "protein_names": [ { "name": "Uncharacterized protein KIAA2013 homolog", "type": "recommended", "evidence": [ { "id": "Q2KHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein KIAA2013 homolog precursor", "type": "synonym", "evidence": [ { "id": "NP_001039407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039407" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHV9", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9", "locus": {} } ], "crossref": [ { "id": "Q2KHV9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019388", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506454", "url": "https://www.ncbi.nlm.nih.gov/gene/506454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506454", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506454", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAEIHRW", "url": "https://omabrowser.org/oma/group/LAEIHRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHV9", "url": "https://www.orthodb.org/?gene=Q2KHV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31386", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31386", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31386:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31386:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039407", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHV9", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHV9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFAGSGARRAAGGLQLLPWPHGEPGAAEPSACLEAATHAWRSLRERGEAVLLGPGVPSLVANGFLALDVVANRLWVTPGEREPAVAPDFVPFVQLRPLSALPEAGESVLLLREGLLRRVRCLQLGTSGPGPAAAGPGPASASGLLTGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPRAFTSTLEKVGDHQFLLYSGRSPPVPTGLVHLVVVAAKKLVDRLQVAPRTQLDETVLWVVHVSGPLNPQVLKSKAAKELKVLQDLARKEMLELLEMPAAELLQDHQRLWAQLFSPGVEMKKITDAHTPSGLTVNLTLYYMLSCSPAPLLSPDLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLWDLWRLTLQKRGCKGLVRAGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQLVKIYACEAGCLDEPVELTSAPQGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPFFRNKEDPSV", "length": 634, "header": "sp|Q2KHV9-1|K2013_BOVIN Isoform 1 of Uncharacterized protein KIAA2013 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KHV9-1" }, "isoforms": [ { "isoform_ac": "Q2KHV9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9/entry#Q2KHV9-1", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFAGSGARRAAGGLQLLPWPHGEPGAAEPSACLEAATHAWRSLRERGEAVLLGPGVPSLVANGFLALDVVANRLWVTPGEREPAVAPDFVPFVQLRPLSALPEAGESVLLLREGLLRRVRCLQLGTSGPGPAAAGPGPASASGLLTGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPRAFTSTLEKVGDHQFLLYSGRSPPVPTGLVHLVVVAAKKLVDRLQVAPRTQLDETVLWVVHVSGPLNPQVLKSKAAKELKVLQDLARKEMLELLEMPAAELLQDHQRLWAQLFSPGVEMKKITDAHTPSGLTVNLTLYYMLSCSPAPLLSPDLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLWDLWRLTLQKRGCKGLVRAGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQLVKIYACEAGCLDEPVELTSAPQGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPFFRNKEDPSV", "length": 634, "header": "sp|Q2KHV9-1|K2013_BOVIN Isoform 1 of Uncharacterized protein KIAA2013 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KHV9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 110, "start_aa": "Thr", "end_pos": 110, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 224, "start_aa": "Thr", "end_pos": 224, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr224", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 363, "start_aa": "Asn", "end_pos": 363, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn363", "evidence": [ { "id": "Q2KHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506454", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506454", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZNR7-1", "protein_name": "KIAA2013", "gene_name": "KIAA2013", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLLLLLLLLVAYWYLGAGRARHGAGRGAEPRGAAALCLQAAAGPWRAQAERGDALPLPEDEAGGGPGPSLALAGNGFLLLDVAAGRLWVSVAGSGGGPSLPTEYPALVRLRALGARGEARAAQAALRDGAVRRVRCVQTGAGPGGAGECVTVREEVVAHRSRPHLYLQRIRIANPTERVATFEASAPASAPSLGARFATSLEKVEERQFLLSSGRLLLPGSPKVVLMVVAAKKLVSRVQVAPKSTFDETVLSVVYTSEPIEVSRLEETFSKLRESAKKEMLEVMQMGVEDLFQEHQQTWSDLFISGIEMRKITDSHTPSSETVNMTLYYMLSSMPAPLLDPLISGEDREKMEASLNYADHCFSGHATMHAENLWPAKLTSVPQILQLSDLWKLTLQKRGCKALVAAGVHGLMQGMVLSFGGLQFTENHLQFQADPDVLHNSYSLRGIHYNKDLINLAVLLDAEGKPFLHVSVKFQDKPVRLYACEAGCMNEPVELTSEARGHTFPVMVTQPITPLLYISTDLVHLQDLRHTLHLKAILAHEEHMAKQYPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKV", "length": 612 }, "evidence": [ { "id": "Q2KHV9", "url": "https://omabrowser.org/oma/group/Q2KHV9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AC58G7Z5-1", "protein_name": "Uncharacterized protein KIAA2013 homolog isoform X1", "gene_name": "si:dkeyp-104h9.5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFNPPKSIWSKRQIMWLQQRLKGLPSLLSSSWARRVLVGLLVFLIFYYWFLSSDGLLKLFSMSREPGGAAGVCLQTDLHRWVSMADRGDGVVHTPQTKESGTFVVGNGHFLVDVDSNKLWVASSTQPGSAPVHQTDYSPIARLQVPGTRSEAQAMMLWYRKGSVLSSRCFQTAKSQSSRDCIVIREEFIAHRSRHNVHLQRILISNPTDHMVSVDMSLESLSFRSKMEKMDDKEFAVSSGRVLTEKKDTVLVVVATNRISNKIQVPSKSEYSANLVSVIHTSEPTEGGKLDDTLDKLRDRVRKEMVDVLRVDVEELMQEHQQAWVDLFISGVEIRKITDAHTPSSRTVNNTLYYILSTSTAPLLDQSLTSEDHEHLESSLNYADHCFSGHATMHAENLWPERLTNVAQILQLVNLWNLTLQKRGCKVLVAAGTHGMMQGMVLSFGGLQFTENHLQFQADPDVLHNSYSLRGIHYNKDLINLAVLQDIEGKPFLHVSVKPQEKPVKLYACEAGCMNEPVELTSELKGHTFPVMVTQPITPLLYISTDLTHLQDLRHTMHVKAILAHEDHMAKQYPGLPFLFWFSVASLITLFHFFLFKLIYNEYCGPGAKPLFRSKDDASV", "length": 620 }, "evidence": [ { "id": "Q2KHV9", "url": "https://omabrowser.org/oma/group/Q2KHV9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZLT7-1", "protein_name": "RIKEN cDNA 2510039O18 gene like", "gene_name": "2510039O18Rikl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLLLLLWFASSGARRAAGGLHLPSWARSEPGAAEPSACLEAATRAWRGLRDRGEAVPLGPGVPALVANGFLALDAANNRLWVTPGEREPAVTPDFVPFVQLRPLNVVAEAGEAVLLLREGLLRRVRCLQLGTPGSGPAAGVPGPASASGLSTGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAAFQTVGPTSGPVPKSFTSTLEKVGDHQFLLYSGRSTPLPSGLVHLVVVTSKKLVNRLQVAPKTQMDETVLWVVHVSAPIHPQVLKSKGTKELKALQDLARKEMLELLEMPASELLQDHQYLWAQLFSPGVEMKRITDAHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHRERDQMEATLNYEDHCFSGHATMHAENLWPGQLSSVQQILQLADLWKLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPEVLHNSYALHGIRYKNDHISLAVLADAEGKPYLHVSLESRGQPVKIYACEAGCLHDPVELTSEPGGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV", "length": 634 }, "evidence": [ { "id": "Q2KHV9", "url": "https://omabrowser.org/oma/group/Q2KHV9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IYS2-1", "protein_name": "Uncharacterized protein KIAA2013", "gene_name": "KIAA2013", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLLLLLWFGGSGARRAAGGLHLLPWSRGEPGAAEPSACLEAATRAWRGLRERGEVVPLGPGVPALVANGFLALDVAANRLWVTPGEREPAVAPDFVPFVQLRPLSALAEAGEAVLLLREGLLRRVRCLQLGSPGPGPVAAGPGPASVSGLAAGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPKAFTSTLEKVGDHQFLLYSGRSPPTPTGLVHLVVVAAKKLVNRLQVAPKTQLDETVLWVVHVSGPINPQVLKSKAAKELKALQDLARKEMLELLDMPAAELLQDHQLLWAQLFSPGVEMKKITDTHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLSDLWRLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQPVKIYACKAGCLDEPVELTSAPTGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV", "length": 634 }, "evidence": [ { "id": "Q2KHV9", "url": "https://omabrowser.org/oma/group/Q2KHV9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91X21-1", "protein_name": "Uncharacterized protein KIAA2013", "gene_name": "Kiaa2013", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFASSGARRAAGGLHLPSWARSEPGAAEPSACLEAATRAWRGLRDRGEAVPLGPGVPALVANGFLALDASNNRLWVTPGEREPAVTPDFVPFVQLRPLNVVAEAGEAVLLLREGLLRRVRCLQLGTPGSGPAAGVPGPASASGLSAGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPVPKSFTSTLEKVGDHQFLLYSGRSTPLPSGLVHLVVVTSKKLVNRLQVAPKTQLDETVLWVVHISGPIHPQVLKSKGAKELKALQDLARKEMLELLEMPASELLQDHQYLWAQLFSPGVEMKRITDAHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHREREQMEATLNYEDHCFSGHATMHAENLWPGQLSSVQQILQLADLWKLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPEVLHNSYALHGIRYKNDHINLAVLVDAEGKPYLHVSLESRGQPVKIYACEAGCLHDPVELTSEPGGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV", "length": 634 }, "evidence": [ { "id": "Q2KHV9", "url": "https://omabrowser.org/oma/group/Q2KHV9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KHV9", "url": "https://www.uniprot.org/uniprotkb/Q2KHV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 634, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 363 ], "o_linked_sites": [ 110, 224 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 363, "end_pos": 365 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHW8-1", "uniprot_ac": "Q2KHW8", "uniprot_id": "GEMI6_BOVIN", "mass": { "chemical_mass": 18724.0, "monoisotopic_mass": 18724.0 }, "refseq": { "ac": "NP_001039743", "name": "gem-associated protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039743" }, "gene_names": [ { "name": "GEMIN6", "type": "recommended", "evidence": [ { "id": "Q2KHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ] }, { "name": "GEMIN6", "type": "synonym", "evidence": [ { "id": "NP_001039743", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039743" } ] } ], "protein_names": [ { "name": "Gem-associated protein 6", "type": "recommended", "evidence": [ { "id": "Q2KHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8/entry#names_and_taxonomy" } ] }, { "name": "Gemin-6", "type": "synonym", "evidence": [ { "id": "Q2KHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8/entry#names_and_taxonomy" } ] }, { "name": "gem-associated protein 6", "type": "synonym", "evidence": [ { "id": "NP_001039743", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039743" } ] }, { "name": "gemin-6", "type": "synonym", "evidence": [ { "id": "NP_001039743", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039743" } ] } ], "function": [ { "annotation": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8#function" }, { "database": "UniProtKB", "id": "Q8WXD5", "url": "https://www.uniprot.org/uniprotkb/Q8WXD5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GEMIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8", "locus": {} } ], "crossref": [ { "id": "Q2KHW8", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11676", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11676", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525263", "url": "https://www.ncbi.nlm.nih.gov/gene/525263", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525263", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525263", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LEWEDYV", "url": "https://omabrowser.org/oma/group/LEWEDYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHW8", "url": "https://www.orthodb.org/?gene=Q2KHW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14710:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14710:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039743", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHW8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNEWMKKGPLEWQDYTYKAVSVTASDKEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVEIVNEGDHSVREKLMHLFMSGDCKAYSPEDLEKRKNSLKKWLEKNHIPITEQRDSRKTLCVAGVLTIDPPYGPENCNSSNEIILSRVQDLIQGHLEASQ", "length": 166, "header": "sp|Q2KHW8-1|GEMI6_BOVIN Isoform 1 of Gem-associated protein 6 OS=Bos taurus OX=9913 GN=GEMIN6 PE=2 SV=1 CANONICAL=Q2KHW8-1" }, "isoforms": [ { "isoform_ac": "Q2KHW8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8/entry#Q2KHW8-1", "sequence": { "sequence": "MNEWMKKGPLEWQDYTYKAVSVTASDKEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVEIVNEGDHSVREKLMHLFMSGDCKAYSPEDLEKRKNSLKKWLEKNHIPITEQRDSRKTLCVAGVLTIDPPYGPENCNSSNEIILSRVQDLIQGHLEASQ", "length": 166, "header": "sp|Q2KHW8-1|GEMI6_BOVIN Isoform 1 of Gem-associated protein 6 OS=Bos taurus OX=9913 GN=GEMIN6 PE=2 SV=1 CANONICAL=Q2KHW8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 165, "end_pos": 165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "site_lbl": "Ser165" }, { "start_pos": 94, "end_pos": 94, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "site_lbl": "Ser94" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525263", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525263", "resource": "KEGG Pathway" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GCC8-1", "protein_name": "Gem-associated protein 6", "gene_name": "Gemin6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDMPREFQNPPEAICFRSSQLVTMSEWMKKSPLEWEDYVYKEVRVIASEKKEYQGWLLTTDPVSANIVLVNFLEDGSLSVTGIMGHCVQTVETLSEGDHRVREKLMHLFTSGDCKGYSPEDLEKRKNSLKKWLEKNHIPVTEQGDAQRTLCVAGVLTIDPPYAPENCSSSNEIILSRVQDLIQGHLSASQ", "length": 190 }, "evidence": [ { "id": "Q2KHW8", "url": "https://omabrowser.org/oma/group/Q2KHW8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V972-1", "protein_name": "Gem-associated protein 6", "gene_name": "Gemin6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEWTKKSPLEWEDYVYKEVRVIASEKEYKGWLLTTDPVSANIVLVNFLEDGRLCVTGIMGHSVQTVETVSEGDHRVREKLMHLFTSADCKGYSPEDLEKKKTSLKKWLEKNHIPVTEEGDTQRTLCVAGVLTIDPPYAPENCSSSNEIILSRIQDLIQGHLSASQ", "length": 166 }, "evidence": [ { "id": "Q2KHW8", "url": "https://omabrowser.org/oma/group/Q2KHW8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WXD5-1", "protein_name": "Gem-associated protein 6", "gene_name": "GEMIN6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ", "length": 167 }, "evidence": [ { "id": "Q2KHW8", "url": "https://omabrowser.org/oma/group/Q2KHW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CX53-1", "protein_name": "Gem-associated protein 6", "gene_name": "Gemin6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEWMKKSPLEWEDYVYKEVRVIACEKEYKGWLLTTDPVSANIVLVNFLEDGRLSVTGIMGHSVQTVETISEGDHRVREKLMHVFASGDCKGYSPEDLEEKRTSLKKWLEKNHIPVTEQGDAQRTLCVAGVLTIDPPYAPENCSSSNEIILSRIQDLIQGHLSASQ", "length": 166 }, "evidence": [ { "id": "Q2KHW8", "url": "https://omabrowser.org/oma/group/Q2KHW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" }, { "name": "SMN complex", "id": "GO:0032797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032797", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" }, { "name": "SMN-Sm protein complex", "id": "GO:0034719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034719", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" }, { "name": "Gemini of Cajal bodies", "id": "GO:0097504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097504", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spliceosomal snRNP assembly", "id": "GO:0000387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000387", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" }, { "name": "spliceosomal complex assembly", "id": "GO:0000245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000245", "evidence": [ { "database": "UniProtKB", "id": "Q2KHW8", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHW8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHW8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHW8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" }, { "id": "PRU01345", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01345" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AD", "eco_id": "ECO_0000255", "start_pos": 68, "end_pos": 166, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW8" }, { "id": "PRU01346", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01346" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sm", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 73, "start_aa": "Trp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 94, 165 ], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHX3-1", "uniprot_ac": "Q2KHX3", "uniprot_id": "PRAF2_BOVIN", "mass": { "chemical_mass": 19174.0, "monoisotopic_mass": 19174.0 }, "refseq": { "ac": "NP_001039474", "name": "PRA1 family protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039474" }, "gene_names": [ { "name": "PRAF2", "type": "recommended", "evidence": [ { "id": "Q2KHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3" } ] }, { "name": "PRAF2", "type": "synonym", "evidence": [ { "id": "NP_001039474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039474" } ] } ], "protein_names": [ { "name": "PRA1 family protein 2", "type": "recommended", "evidence": [ { "id": "Q2KHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3/entry#names_and_taxonomy" } ] }, { "name": "PRA1 family protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039474" } ] } ], "function": [ { "annotation": "May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRAF2", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3", "locus": { "chromosome": "X", "start_pos": 87153480, "end_pos": 87156389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002562", "url": "https://www.ensembl.org/id/ENSBTAG00000002562" } ] } } ], "crossref": [ { "id": "Q2KHX3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002562", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002562", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508703", "url": "https://www.ncbi.nlm.nih.gov/gene/508703", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508703", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508703", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDPQRWC", "url": "https://omabrowser.org/oma/group/GDPQRWC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHX3", "url": "https://www.orthodb.org/?gene=Q2KHX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12859:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12859:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039474", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHX3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178, "header": "sp|Q2KHX3-1|PRAF2_BOVIN Isoform 1 of PRA1 family protein 2 OS=Bos taurus OX=9913 GN=PRAF2 PE=2 SV=1 CANONICAL=Q2KHX3-1" }, "isoforms": [ { "isoform_ac": "Q2KHX3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3/entry#Q2KHX3-1", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178, "header": "sp|Q2KHX3-1|PRAF2_BOVIN Isoform 1 of PRA1 family protein 2 OS=Bos taurus OX=9913 GN=PRAF2 PE=2 SV=1 CANONICAL=Q2KHX3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508703", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508703", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HX82-1", "protein_name": "PRA1 family protein", "gene_name": "Praf2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLAAPDPGDPQRWCHRVINNLLYYQTNYLLCFGISLALAGYIRPLHTLLSALVVVVALGVLVWAAETRAAMRRCRRSHPAACLAAVLAISLLILWAVGGAFTFLLCITAPVLLILLHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178 }, "evidence": [ { "id": "Q2KHX3", "url": "https://omabrowser.org/oma/group/Q2KHX3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A0G2JTX2-1", "protein_name": "PRA1 family protein", "gene_name": "Praf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLAAPDLGDPQRWCHRVINNLLYYQTNYLLCFGISLALAGYIRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVSLFILWAVGGAFTFLLCITAPVLLILLHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178 }, "evidence": [ { "id": "Q2KHX3", "url": "https://omabrowser.org/oma/group/Q2KHX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60831-1", "protein_name": "PRA1 family protein 2", "gene_name": "PRAF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178 }, "evidence": [ { "id": "Q2KHX3", "url": "https://omabrowser.org/oma/group/Q2KHX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JIG8-1", "protein_name": "PRA1 family protein 2", "gene_name": "Praf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLAAPDPGDPQRWCHRVINNLLYYQTNYLLCFGISLALAGYIRPLHTLLSALVVVVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAISLFILWAVGGAFTFLLSITAPVFLILLHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178 }, "evidence": [ { "id": "Q2KHX3", "url": "https://omabrowser.org/oma/group/Q2KHX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX3", "url": "https://www.uniprot.org/uniprotkb/Q2KHX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHX3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHX8-1", "uniprot_ac": "Q2KHX8", "uniprot_id": "RCL1_BOVIN", "mass": { "chemical_mass": 41010.0, "monoisotopic_mass": 41010.0 }, "refseq": { "ac": "NP_001070599", "name": "RNA 3'-terminal phosphate cyclase-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070599" }, "gene_names": [ { "name": "RCL1", "type": "recommended", "evidence": [ { "id": "Q2KHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ] }, { "name": "RCL1", "type": "synonym", "evidence": [ { "id": "NP_001070599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070599" } ] } ], "protein_names": [ { "name": "RNA 3'-terminal phosphate cyclase-like protein", "type": "recommended", "evidence": [ { "id": "Q2KHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8/entry#names_and_taxonomy" } ] }, { "name": "RNA 3'-terminal phosphate cyclase-like protein", "type": "synonym", "evidence": [ { "id": "NP_001070599", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070599" } ] } ], "function": [ { "annotation": "As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA. Activates BMS1 by promoting GDP/GTP exchange. Does not have cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MRF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF2#function" }, { "database": "UniProtKB", "id": "ARBA00056741", "url": "https://www.uniprot.org/uniprotkb/ARBA00056741#function" }, { "database": "UniProtKB", "id": "A0A3Q1NKG1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKG1#function" }, { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8#function" }, { "database": "UniProtKB", "id": "Q08096", "url": "https://www.uniprot.org/uniprotkb/Q08096#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5V9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5V9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCL1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8", "locus": { "chromosome": "8", "start_pos": 39548837, "end_pos": 39743422, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018667", "url": "https://www.ensembl.org/id/ENSBTAG00000018667" } ] } } ], "crossref": [ { "id": "Q2KHX8", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018667", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018667", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00875", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00875", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768075", "url": "https://www.ncbi.nlm.nih.gov/gene/768075", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768075", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768075", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YTDQNKG", "url": "https://omabrowser.org/oma/group/YTDQNKG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRF2", "url": "https://www.orthodb.org/?gene=A0A3Q1MRF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKG1", "url": "https://www.orthodb.org/?gene=A0A3Q1NKG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KHX8", "url": "https://www.orthodb.org/?gene=Q2KHX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11096", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11096", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11096:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11096:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01137", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01137", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070599", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKG1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKG1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5V9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5V9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5V9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5V9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHX8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK", "length": 373, "header": "sp|Q2KHX8-1|RCL1_BOVIN Isoform 1 of RNA 3'-terminal phosphate cyclase-like protein OS=Bos taurus OX=9913 GN=RCL1 PE=2 SV=1 CANONICAL=Q2KHX8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRF2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8/entry#A0A3Q1MRF2-1", "sequence": { "sequence": "MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTSPRPAKVNCAACVLKIPLATQGINAFFSCWITKQKRPSQTTHVRFVLIFAVIQLAEASHIHDYTQRQW", "length": 392, "header": "tr|A0A3Q1MRF2-1|A0A3Q1MRF2_BOVIN Computationally mapped isoform of RNA 3'-terminal phosphate cyclase-like protein OS=Bos taurus OX=9913 GN=RCL1 PE=3 SV=2 CANONICAL=Q2KHX8-1" }, "locus": { "chromosome": "8", "start_pos": 39743313, "end_pos": 39548837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073600.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073600.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074347.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074347.2" } ] } }, { "isoform_ac": "A0A3Q1NKG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8/entry#A0A3Q1NKG1-1", "sequence": { "sequence": "MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIDWFDLLAIREALKSLRQHHNSKASILQGSAFFTVQLSQLYMTTGKTAALTIWQRDVGKEMSLLFNILSWFVIALLLRQD", "length": 404, "header": "tr|A0A3Q1NKG1-1|A0A3Q1NKG1_BOVIN Computationally mapped isoform of RNA 3'-terminal phosphate cyclase-like protein OS=Bos taurus OX=9913 GN=RCL1 PE=3 SV=2 CANONICAL=Q2KHX8-1" }, "locus": { "chromosome": "8", "start_pos": 39743313, "end_pos": 39574547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073216.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073216.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072818.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072818.2" } ] } }, { "isoform_ac": "A0AAF6Z5V9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8/entry#A0AAF6Z5V9-1", "sequence": { "sequence": "MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIFAAFEELFPDYV", "length": 337, "header": "tr|A0AAF6Z5V9-1|A0AAF6Z5V9_BOVIN Computationally mapped isoform of RNA 3'-terminal phosphate cyclase-like protein OS=Bos taurus OX=9913 GN=RCL1 PE=3 SV=1 CANONICAL=Q2KHX8-1" }, "locus": { "chromosome": "8", "start_pos": 39743313, "end_pos": 39679011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024840.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024840.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024840.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024840.4" } ] } }, { "isoform_ac": "Q2KHX8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8/entry#Q2KHX8-1", "sequence": { "sequence": "MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK", "length": 373, "header": "sp|Q2KHX8-1|RCL1_BOVIN Isoform 1 of RNA 3'-terminal phosphate cyclase-like protein OS=Bos taurus OX=9913 GN=RCL1 PE=2 SV=1 CANONICAL=Q2KHX8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768075", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768075", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C1K6-1", "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "RCL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGGGAQCLSFAGCNFLRQRLVLSTLSGRPLKIRKIRAKEEDPGLRDFEACFIRLIDKVTNGSRIEINQTGTTLYYQPGLLYGGSLEHDCSPSRSIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKKFGIDGESLEIKINRRGMPPKGGGEILFACPVRKVLQPIQFTDPGKIKRIRGTAYSVRVSPQMANRMVESARSVLNKFLPDVYIYTDHMKGISSGKSPGFGICLIAETINGTILSAELASNPQGQGAAVLPEELGQNCAKLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLRSFFQIMFKIEMKSPEEEHKGGEKVLMTCVGIGFSNLSKTIR", "length": 374 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V7Z1-1", "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rcl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRRIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLEALLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKILRRGMPPGGGGEVLFSCPVRKVLKPVQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARGILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAVLPEDLGRNCAKLLLEEIYRGGCVDSTSQSLVLLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQVMFKVETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK", "length": 373 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P56175-1", "protein_name": "Probable RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rtc1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPIAQEGNCLIYRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKIELNPAGTSVMFSPGLLHGGQLNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSVDHIKGAALSLLKRFLLVDEGLELKVVRRGVAPLGGGEIIFRCPVRKSLRAIQFQSQGMVKRIRGTVYACKVSPAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSPGFGICLIAETTDGVCFAADCCSNTREESEDTPSIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQKHVSKFLTGALSNYTVHFLQHLRDFFSITFKLENPEAEDEDEAENVRGAQKVLMACVGIGYTNINKRVI", "length": 384 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q08096-1", "protein_name": "rRNA processing protein RCL1", "gene_name": "RCL1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSSAPKYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKGIGFTNTSKKIA", "length": 367 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54S38-1", "protein_name": "Probable RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "rcl1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLKFQGSTHFRQRIICSTLSGKAIRITNIRDEDEKPGLRDYEASFLRLVDKITNGSKIEINSTGTQITYIPGIIIGGKGITHECGTVRGIGYFVEALICLGPFAKAPLDITLNGITNNDIDLTIDTIRTTTLPIIRKFGIEEGLIIKIIKRGAPPNGGGSVNFKCPIVPHLKAIQLIDEGKIRRIRGIAYATRISPQFSNRVLDKAKGLLLEYTPDVYISSDHYKGNESGLSPGYGLTLVAETTTGCCLSAECMSNTGIATTEQQLQKQKSTSETPEDLGERTAFALLEEIFNGGCIDSHNQSLALLFMVLCPEDISKVRLGKITPYTIEFIRQLRDFFGVTFKIEPDQNSKTVLFTCLGIGYKNMARSTF", "length": 371 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C578-1", "protein_name": "Probable RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVMMKKMKGSQSFRQRLLLSTLSSTPISIDEIRADETIPGLRPHEVNLLRLLEIVTDDAVVDINETGTRLKYKPGTIVGGKNLVHSCSLSRSIGYYLEPLLLLGLFGKKPLSIRLKGITNDPRDASVDTFRSTTLNIIKRFGVPAEDLELKIEARGVAPNGGGEVLLTVPNIKTLSAVHWVEEGMVKKIRGTTFSTRVTSDFEHSMRFAARGIFNNLLPDVHIFQDHRAGAQAGKSPGYGISLAAETTTGCFISADTTVSCERPDETGELDVEKKERSPAEDTGVEVASWLLQEIEKGGVVDSTHQGLLFLLCALSEQDVSKVRVGTLSPYAVETLRNIKEFLGVKFAIKPDPLTGTVILKCTGSGLINLSRKLS", "length": 375 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JJT0-1", "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rcl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRRIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLEALLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKILRRGMPPGGGGEVLFSCPVRKVLKPVQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVSSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAVLPEDLGRNCAKLLLEEIYRGGCVDSTNQSLVLLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQVMFKVETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK", "length": 373 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2P8-1", "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "RCL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK", "length": 373 }, "evidence": [ { "id": "Q2KHX8", "url": "https://omabrowser.org/oma/group/Q2KHX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000479", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" }, { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "Q2KHX8", "url": "https://www.uniprot.org/uniprotkb/Q2KHX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 373, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHX8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 367, "end_pos": 369 }, { "start_pos": 60, "end_pos": 62 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHY5-1", "uniprot_ac": "Q2KHY5", "uniprot_id": "FAP24_BOVIN", "mass": { "chemical_mass": 23879.0, "monoisotopic_mass": 23879.0 }, "refseq": { "ac": "NP_001039527", "name": "Fanconi anemia core complex-associated protein 24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" }, "gene_names": [ { "name": "FAAP24", "type": "recommended", "evidence": [ { "id": "Q2KHY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ] }, { "name": "C18H19orf40", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] }, { "name": "FAAP24", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] } ], "protein_names": [ { "name": "Fanconi anemia core complex-associated protein 24", "type": "recommended", "evidence": [ { "id": "Q2KHY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5/entry#names_and_taxonomy" } ] }, { "name": "Fanconi anemia core complex associated protein 24", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] }, { "name": "Fanconi anemia core complex-associated protein 24", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] }, { "name": "Fanconi anemia-associated protein of 24 kDa", "type": "synonym", "evidence": [ { "id": "Q2KHY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5/entry#names_and_taxonomy" } ] }, { "name": "Fanconi anemia-associated protein, 24 kDa", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] }, { "name": "fanconi anemia-associated protein of 24 kDa", "type": "synonym", "evidence": [ { "id": "NP_001039527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527" } ] } ], "function": [ { "annotation": "Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAAP24", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5", "locus": { "chromosome": "18", "start_pos": 43408232, "end_pos": 43398431, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010403", "url": "https://www.ensembl.org/id/ENSBTAG00000010403" } ] } } ], "crossref": [ { "id": "Q2KHY5", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010403", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010403", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20076", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510793", "url": "https://www.ncbi.nlm.nih.gov/gene/510793", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510793", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510793", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPVHVPF", "url": "https://omabrowser.org/oma/group/GPVHVPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KHY5", "url": "https://www.orthodb.org/?gene=Q2KHY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31786", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31786", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31786:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31786:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17949", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17949", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039527", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHY5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESNPPDSTGPMHVPFGHIVANEKWRGSQLAQGMQGKIKLVFEDGLTPVDFYLSSKSCILYITEAELVAGNGYRKRLVRVRNSNKLQGIVVVEKTQMSEQYFPAVQKFTVLDLGMVLLPVASQMEASCLIIQLVQEQTREPSKNPFLRKKRALVSEPALLRSVQQIPGVGKVKAPLLLQRFPSIQQLSNASLRELEAVVGPAAAQRIHAFFSQPR", "length": 215, "header": "sp|Q2KHY5-1|FAP24_BOVIN Isoform 1 of Fanconi anemia core complex-associated protein 24 OS=Bos taurus OX=9913 GN=FAAP24 PE=2 SV=1 CANONICAL=Q2KHY5-1" }, "isoforms": [ { "isoform_ac": "Q2KHY5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5/entry#Q2KHY5-1", "sequence": { "sequence": "MESNPPDSTGPMHVPFGHIVANEKWRGSQLAQGMQGKIKLVFEDGLTPVDFYLSSKSCILYITEAELVAGNGYRKRLVRVRNSNKLQGIVVVEKTQMSEQYFPAVQKFTVLDLGMVLLPVASQMEASCLIIQLVQEQTREPSKNPFLRKKRALVSEPALLRSVQQIPGVGKVKAPLLLQRFPSIQQLSNASLRELEAVVGPAAAQRIHAFFSQPR", "length": 215, "header": "sp|Q2KHY5-1|FAP24_BOVIN Isoform 1 of Fanconi anemia core complex-associated protein 24 OS=Bos taurus OX=9913 GN=FAAP24 PE=2 SV=1 CANONICAL=Q2KHY5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510793", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510793", "resource": "KEGG Pathway" }, { "id": "R-BTA-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P406-1", "protein_name": "Fanconi anemia core complex associated protein 24", "gene_name": "FAAP24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAKGDVPAAAGSVVVPYGHVVGNEKWRGSEVARRLQGKTKLIFEDGLGLVDFHLSNRICVLYISEADLVAGDEFKRRVVRFRNASSLGGIVIVEKTPITEQYFSAVQKLVVLQLGMVLLPVANQGEASQLITQLVREQSKDHTSNPFLRKQCSQLAEASVFRTVQQIPGVGKTKALLLLQQFGSIHQICNASVKELELVVGQTVAQQIHTFLGS", "length": 215 }, "evidence": [ { "id": "Q2KHY5", "url": "https://omabrowser.org/oma/group/Q2KHY5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TS87-1", "protein_name": "Fanconi anemia core complex-associated protein 24", "gene_name": "FAAP24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGNAPDGTGPVHVPFGHIVANEKWRGSQLAQGMQGKIKLIFEDGLTPVDFYLPSRSCILYITEADLVAGNGYRKRLVRVRNSTKLQAIVVVEKTQMSEQYFPAAQKFTVLDLGMVLLPVANQIEAACLITQLVQEQTKEPSKNPVLRRKRAVISEPALLRTVQRIPGVGKVKAPLLLQRFPSIQQLSNASVQELEPVVGQAVARHVHAFFTQPR", "length": 215 }, "evidence": [ { "id": "Q2KHY5", "url": "https://omabrowser.org/oma/group/Q2KHY5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZE71-1", "protein_name": "Fanconi anemia core complex-associated protein 24", "gene_name": "Faap24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERNPPGGTGPVHVPLGHIVANEKWRGSQLAQELQGKVRLIFEEGLASTDFYLSSKSCILYITEADLVAGHGYKKRLARFRNSAHLQGIVIVEKTQMSEQYFPAAQKFTVLDLGMVLLPVASQSEASCLIFQLVQEQTREPSKNPFLRKKRSMLSESSLVQTVQQIPGVGKVKAPLLLQKFPSIQQLSNASTQELEEVVGRTVAQQIHTFFTQPKRQQSWH", "length": 221 }, "evidence": [ { "id": "Q2KHY5", "url": "https://omabrowser.org/oma/group/Q2KHY5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHL6-1", "protein_name": "Fanconi anemia core complex-associated protein 24", "gene_name": "Faap24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERNPPDGTGPVHVPLGHIVASEKWRGSQLAQEMQGKVRLIFEEGLASADFYLSSKSCILYVTEADLVAGHGYRKRLARFRNSSHLQGIIIVEKTQMSEQYFPAVQKFTVLDLGMVLLPVASQSEASCLIIHLVQEQTREPSKNPFLRKKRSMLSELSLVQTVQQIPGVGKVKAPLLLQKFPSIQQLSNASVQELEEVVGPAAAQQIHTFFTQPKRQQPRS", "length": 221 }, "evidence": [ { "id": "Q2KHY5", "url": "https://omabrowser.org/oma/group/Q2KHY5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BTP7-1", "protein_name": "Fanconi anemia core complex-associated protein 24", "gene_name": "FAAP24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR", "length": 215 }, "evidence": [ { "id": "Q2KHY5", "url": "https://omabrowser.org/oma/group/Q2KHY5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY5", "url": "https://www.uniprot.org/uniprotkb/Q2KHY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHY5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KHY7-1", "uniprot_ac": "Q2KHY7", "uniprot_id": "TTC23_BOVIN", "mass": { "chemical_mass": 49517.0, "monoisotopic_mass": 49517.0 }, "refseq": { "ac": "NP_001039771", "name": "tetratricopeptide repeat protein 23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039771" }, "gene_names": [ { "name": "TTC23", "type": "recommended", "evidence": [ { "id": "Q2KHY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7" } ] }, { "name": "TTC23", "type": "synonym", "evidence": [ { "id": "NP_001039771", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039771" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 23", "type": "recommended", "evidence": [ { "id": "Q2KHY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7/entry#names_and_taxonomy" } ] }, { "name": "TPR repeat protein 23", "type": "synonym", "evidence": [ { "id": "NP_001039771", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039771" }, { "id": "Q2KHY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 23", "type": "synonym", "evidence": [ { "id": "NP_001039771", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039771" } ] } ], "function": [ { "annotation": "Participates positively in the ciliary Hedgehog (Hh) signaling.", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY7", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7#function" }, { "database": "UniProtKB", "id": "Q8CHY7", "url": "https://www.uniprot.org/uniprotkb/Q8CHY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KHY7", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC23", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7", "locus": { "chromosome": "21", "start_pos": 7576775, "end_pos": 7418429, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011185", "url": "https://www.ensembl.org/id/ENSBTAG00000011185" } ] } } ], "crossref": [ { "id": "Q2KHY7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KHY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "529791", "url": "https://www.ncbi.nlm.nih.gov/gene/529791", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529791", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529791", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KHY7", "url": "https://www.orthodb.org/?gene=Q2KHY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14485", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14485", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14485:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14485:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039771", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KHY7", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KHY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQESQETHISNHLDEIVAAVSITPRKKLLNQLLQRALFQPPREKLRLSEEKAKSYASSHEYKKALHELVHCMALTRICYGDSHWKLAEAHVNLAKGYLQLKGMSLRAKQHAEKAKEILTSSVAPPYSDNTDVFKCSVELFHTLGQALLSLQKFKEASKNLTKAEILSKEMLQCGKIIKEEWMEIQARIKLSFAQVYQGQKKSKEALPHYQEALEYTEISRGEKSLECVPILRELAAAEQALGFHDASINNLIQAHLIVLRGSPSREEAATSAHSVACAAIASGRPEHHDVAEQYFQDSMANLKDAEGKETAKFLSIQDDYCHFLQVTGQDEKATSIFRESLEAKVAVFGDFSPEVAETYRLLGVADLAQGNQTGAHKKLKKCLQIQTLLYGPQDKRTLATQQTMDILSKAPEVPARPRPSPGAKAAFCAGGRPYSVPGRTRPSAAD", "length": 446, "header": "sp|Q2KHY7-1|TTC23_BOVIN Isoform 1 of Tetratricopeptide repeat protein 23 OS=Bos taurus OX=9913 GN=TTC23 PE=2 SV=1 CANONICAL=Q2KHY7-1" }, "isoforms": [ { "isoform_ac": "Q2KHY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7/entry#Q2KHY7-1", "sequence": { "sequence": "MQESQETHISNHLDEIVAAVSITPRKKLLNQLLQRALFQPPREKLRLSEEKAKSYASSHEYKKALHELVHCMALTRICYGDSHWKLAEAHVNLAKGYLQLKGMSLRAKQHAEKAKEILTSSVAPPYSDNTDVFKCSVELFHTLGQALLSLQKFKEASKNLTKAEILSKEMLQCGKIIKEEWMEIQARIKLSFAQVYQGQKKSKEALPHYQEALEYTEISRGEKSLECVPILRELAAAEQALGFHDASINNLIQAHLIVLRGSPSREEAATSAHSVACAAIASGRPEHHDVAEQYFQDSMANLKDAEGKETAKFLSIQDDYCHFLQVTGQDEKATSIFRESLEAKVAVFGDFSPEVAETYRLLGVADLAQGNQTGAHKKLKKCLQIQTLLYGPQDKRTLATQQTMDILSKAPEVPARPRPSPGAKAAFCAGGRPYSVPGRTRPSAAD", "length": 446, "header": "sp|Q2KHY7-1|TTC23_BOVIN Isoform 1 of Tetratricopeptide repeat protein 23 OS=Bos taurus OX=9913 GN=TTC23 PE=2 SV=1 CANONICAL=Q2KHY7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529791", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529791", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY7", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q2KHY7", "url": "https://www.uniprot.org/uniprotkb/Q2KHY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KHY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 446, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KHY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KHY7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 371, "end_pos": 373 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI00-1", "uniprot_ac": "Q2KI00", "uniprot_id": "F107B_BOVIN", "mass": { "chemical_mass": 15586.0, "monoisotopic_mass": 15586.0 }, "refseq": { "ac": "NP_001039858", "name": "protein FAM107B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039858" }, "gene_names": [ { "name": "FAM107B", "type": "recommended", "evidence": [ { "id": "Q2KI00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI00" } ] }, { "name": "C10orf45", "type": "synonym", "evidence": [ { "id": "NP_001039858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039858" } ] }, { "name": "FAM107B", "type": "synonym", "evidence": [ { "id": "NP_001039858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039858" } ] } ], "protein_names": [ { "name": "Protein FAM107B", "type": "recommended", "evidence": [ { "id": "Q2KI00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI00/entry#names_and_taxonomy" } ] }, { "name": "protein FAM107B", "type": "synonym", "evidence": [ { "id": "NP_001039858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039858" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI00", "url": "https://www.uniprot.org/uniprotkb/Q2KI00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM107B", "url": "https://www.uniprot.org/uniprotkb/Q2KI00", "locus": { "chromosome": "13", "start_pos": 29216135, "end_pos": 29433959, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010023", "url": "https://www.ensembl.org/id/ENSBTAG00000010023" } ] } } ], "crossref": [ { "id": "Q2KI00", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI00", "database": "AlphaFoldDB", "categories": [] }, { "id": "535023", "url": "https://www.ncbi.nlm.nih.gov/gene/535023", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535023", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535023", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KI00", "url": "https://www.orthodb.org/?gene=Q2KI00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16768", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16768", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16768:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16768:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039858", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI00", "url": "https://www.uniprot.org/uniprotkb/Q2KI00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI00-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPDYIDDDNPELIRPQKLVNPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENPPEFVKVKGNLRRTGQEVAQTQES", "length": 131, "header": "sp|Q2KI00-1|F107B_BOVIN Isoform 1 of Protein FAM107B OS=Bos taurus OX=9913 GN=FAM107B PE=2 SV=1 CANONICAL=Q2KI00-1" }, "isoforms": [ { "isoform_ac": "Q2KI00-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI00/entry#Q2KI00-1", "sequence": { "sequence": "MAEPDYIDDDNPELIRPQKLVNPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENPPEFVKVKGNLRRTGQEVAQTQES", "length": 131, "header": "sp|Q2KI00-1|F107B_BOVIN Isoform 1 of Protein FAM107B OS=Bos taurus OX=9913 GN=FAM107B PE=2 SV=1 CANONICAL=Q2KI00-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535023", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535023", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 131, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI00" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI04-1", "uniprot_ac": "Q2KI04", "uniprot_id": "SZRD1_BOVIN", "mass": { "chemical_mass": 16907.0, "monoisotopic_mass": 16907.0 }, "refseq": { "ac": "NP_001108080", "name": "SUZ RNA-binding domain-containing", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" }, "gene_names": [ { "name": "SZRD1", "type": "recommended", "evidence": [ { "id": "Q2KI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ] }, { "name": "C1orf144", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] }, { "name": "C2H1orf144", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] }, { "name": "SZRD1", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] } ], "protein_names": [ { "name": "SUZ RNA-binding domain-containing", "type": "recommended", "evidence": [ { "id": "Q2KI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI04/entry#names_and_taxonomy" } ] }, { "name": "SUZ RNA-binding domain-containing", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] }, { "name": "SUZ domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" }, { "id": "Q2KI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI04/entry#names_and_taxonomy" } ] }, { "name": "UPF0485 protein C1orf144 homolog", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] }, { "name": "putative MAPK activating protein PM20,PM21", "type": "synonym", "evidence": [ { "id": "NP_001108080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SZRD1", "url": "https://www.uniprot.org/uniprotkb/Q2KI04", "locus": { "chromosome": "2", "start_pos": 135729181, "end_pos": 135759412, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009251", "url": "https://www.ensembl.org/id/ENSBTAG00000009251" } ] } } ], "crossref": [ { "id": "Q2KI04", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009251", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009251", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512452", "url": "https://www.ncbi.nlm.nih.gov/gene/512452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PACMSVQ", "url": "https://omabrowser.org/oma/group/PACMSVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI04", "url": "https://www.orthodb.org/?gene=Q2KI04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31796", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31796", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31796:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31796:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001108080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI04-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI04-2", "url": "https://www.uniprot.org/uniprotkb/Q2KI04-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 152, "header": "sp|Q2KI04-1|SZRD1_BOVIN Isoform 1 of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=2 SV=2 CANONICAL=Q2KI04-1" }, "isoforms": [ { "isoform_ac": "Q2KI04-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI04/entry#Q2KI04-1", "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 152, "header": "sp|Q2KI04-1|SZRD1_BOVIN Isoform 1 of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=2 SV=2 CANONICAL=Q2KI04-1" }, "locus": {} }, { "isoform_ac": "Q2KI04-2", "url": "https://www.uniprot.org/uniprotkb/Q2KI04/entry#Q2KI04-2", "sequence": { "sequence": "MRRSLKAGRRRQTAGKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 132, "header": "sp|Q2KI04-2|SZRD1_BOVIN Isoform 2 of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=2 SV=2 CANONICAL=Q2KI04-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "site_lbl": "Ser105" }, { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "site_lbl": "Ser107" }, { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "site_lbl": "Ser37" }, { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "site_lbl": "Ser39" }, { "start_pos": 51, "end_pos": 51, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI04", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" } ], "site_lbl": "Ser51" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512452", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5XIA2-1", "protein_name": "SUZ RNA-binding domain-containing", "gene_name": "Szrd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPTGPPPQIRILKRPTSNGVVSSPNSTSRPALPVKSLAQREAEYAEARRRILGSASPEEEQEKPILDRPTRISQPEDSRQPSNVIRQPLGPDGSQGFKQRR", "length": 152 }, "evidence": [ { "id": "Q2KI04", "url": "https://omabrowser.org/oma/group/Q2KI04/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NXN1-1", "protein_name": "SUZ RNA-binding domain-containing", "gene_name": "Szrd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPTGPPPQIRILKRPTSNGVVSSPNSTSRPALPVKSLAQREAEYAEARRRILGSASPEEEQEKPILDRPTRISQPEDSRQPSNVIRQPLGPDGSQGFKQRR", "length": 152 }, "evidence": [ { "id": "Q2KI04", "url": "https://omabrowser.org/oma/group/Q2KI04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z422-1", "protein_name": "SUZ RNA-binding domain-containing", "gene_name": "SZRD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSSPNSTSRPTLPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 152 }, "evidence": [ { "id": "Q2KI04", "url": "https://omabrowser.org/oma/group/Q2KI04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI04" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" }, { "id": "PRU01009", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01009" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUZ", "eco_id": "ECO_0000255", "start_pos": 42, "end_pos": 107, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI04" }, { "id": "PRU01287", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01287" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUZ-C", "eco_id": "ECO_0000255", "start_pos": 111, "end_pos": 152, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 37, 39, 51, 105, 107 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI08-1", "uniprot_ac": "Q2KI08", "uniprot_id": "TOM7_BOVIN", "mass": { "chemical_mass": 6218.0, "monoisotopic_mass": 6218.0 }, "refseq": { "ac": "NP_001106777", "name": "mitochondrial import receptor subunit TOM7 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" }, "gene_names": [ { "name": "TOMM7", "type": "recommended", "evidence": [ { "id": "Q2KI08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI08" } ] }, { "name": "TOMM7", "type": "synonym", "evidence": [ { "id": "NP_001106777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" } ] }, { "name": "Tom7", "type": "synonym", "evidence": [ { "id": "NP_001106777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" } ] } ], "protein_names": [ { "name": "Mitochondrial import receptor subunit TOM7 homolog", "type": "recommended", "evidence": [ { "id": "Q2KI08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI08/entry#names_and_taxonomy" } ] }, { "name": "Translocase of outer membrane 7 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "Q2KI08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI08/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import receptor subunit TOM7 homolog", "type": "synonym", "evidence": [ { "id": "NP_001106777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" } ] }, { "name": "translocase of outer membrane 7 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "NP_001106777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" } ] }, { "name": "translocase of outer mitochondrial membrane 7 homolog", "type": "synonym", "evidence": [ { "id": "NP_001106777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777" } ] } ], "function": [ { "annotation": "Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08#function" }, { "database": "UniProtKB", "id": "Q9P0U1", "url": "https://www.uniprot.org/uniprotkb/Q9P0U1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM7", "url": "https://www.uniprot.org/uniprotkb/Q2KI08", "locus": {} } ], "crossref": [ { "id": "Q2KI08", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614074", "url": "https://www.ncbi.nlm.nih.gov/gene/614074", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614074", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614074", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMNLLWQ", "url": "https://omabrowser.org/oma/group/LMNLLWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI08", "url": "https://www.orthodb.org/?gene=Q2KI08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46722:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46722:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5205685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106777", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI08-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLSLLWG", "length": 55, "header": "sp|Q2KI08-1|TOM7_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM7 homolog OS=Bos taurus OX=9913 GN=TOMM7 PE=3 SV=1 CANONICAL=Q2KI08-1" }, "isoforms": [ { "isoform_ac": "Q2KI08-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI08/entry#Q2KI08-1", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLSLLWG", "length": 55, "header": "sp|Q2KI08-1|TOM7_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM7 homolog OS=Bos taurus OX=9913 GN=TOMM7 PE=3 SV=1 CANONICAL=Q2KI08-1" }, "locus": { "chromosome": "4", "start_pos": 31527748, "end_pos": 31520663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150947.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150947.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104219.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104219.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614074", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614074", "resource": "KEGG Pathway" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RYN1-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "TOMM7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKLSKEAKQRLQQLFKGGQFAIRWGFIPVVLYLGFRRGADPGMPEPTIWSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2QPV1-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "Tomm7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGMPEPSVLSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1XQS2-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "TOMM7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZMR1-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "Tomm7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGMPEPSVLSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D173-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "Tomm7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGMPEPSVLSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0U1-1", "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "TOMM7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVKLSKEAKQRLQQLFKGSQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLSLLWG", "length": 55 }, "evidence": [ { "id": "Q2KI08", "url": "https://omabrowser.org/oma/group/Q2KI08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of protein targeting to mitochondrion", "id": "GO:1903955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903955", "evidence": [ { "database": "UniProtKB", "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane translocase complex", "id": "GO:0005742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005742", "evidence": [ { "database": "UniProtKB", "id": "Q2KI08", "url": "https://www.uniprot.org/uniprotkb/Q2KI08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 55, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI08" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI29-1", "uniprot_ac": "Q2KI29", "uniprot_id": "TM256_BOVIN", "mass": { "chemical_mass": 11775.0, "monoisotopic_mass": 11775.0 }, "refseq": { "ac": "NP_001039422", "name": "transmembrane protein 256 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" }, "gene_names": [ { "name": "TMEM256", "type": "recommended", "evidence": [ { "id": "Q2KI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI29" } ] }, { "name": "C17orf61", "type": "synonym", "evidence": [ { "id": "NP_001039422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" } ] }, { "name": "C19H17orf61", "type": "synonym", "evidence": [ { "id": "NP_001039422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" } ] }, { "name": "TMEM256", "type": "synonym", "evidence": [ { "id": "NP_001039422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" } ] } ], "protein_names": [ { "name": "Transmembrane protein 256", "type": "recommended", "evidence": [ { "id": "Q2KI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI29/entry#names_and_taxonomy" } ] }, { "name": "UPF0451 protein C17orf61 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" } ] }, { "name": "transmembrane protein 256 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI29", "url": "https://www.uniprot.org/uniprotkb/Q2KI29" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM256", "url": "https://www.uniprot.org/uniprotkb/Q2KI29", "locus": { "chromosome": "19", "start_pos": 27081979, "end_pos": 27083231, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031752", "url": "https://www.ensembl.org/id/ENSBTAG00000031752" } ] } } ], "crossref": [ { "id": "Q2KI29", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI29", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507083", "url": "https://www.ncbi.nlm.nih.gov/gene/507083", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507083", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507083", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YHYSITG", "url": "https://omabrowser.org/oma/group/YHYSITG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI29", "url": "https://www.orthodb.org/?gene=Q2KI29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43461:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43461:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI29", "url": "https://www.uniprot.org/uniprotkb/Q2KI29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI29-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPGAAFRRLGALSGAGALGLASYGAHGAQFPDAYGKELFDKTNKHHFLHSLALLAVPLCRKPLWAGLLLASGTTLFCTTFYYQALSGDPSFQNLAPVGGSLLLLGWLALAL", "length": 113, "header": "sp|Q2KI29-1|TM256_BOVIN Isoform 1 of Transmembrane protein 256 OS=Bos taurus OX=9913 GN=TMEM256 PE=3 SV=1 CANONICAL=Q2KI29-1" }, "isoforms": [ { "isoform_ac": "Q2KI29-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI29/entry#Q2KI29-1", "sequence": { "sequence": "MAGPGAAFRRLGALSGAGALGLASYGAHGAQFPDAYGKELFDKTNKHHFLHSLALLAVPLCRKPLWAGLLLASGTTLFCTTFYYQALSGDPSFQNLAPVGGSLLLLGWLALAL", "length": 113, "header": "sp|Q2KI29-1|TM256_BOVIN Isoform 1 of Transmembrane protein 256 OS=Bos taurus OX=9913 GN=TMEM256 PE=3 SV=1 CANONICAL=Q2KI29-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507083", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507083", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LYI7-1", "protein_name": "Transmembrane protein 256", "gene_name": "Tmem256", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGVGAAFRRLGALSGAGALSLATYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPYCRKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQTLGPVGGSLLILGWLALAF", "length": 113 }, "evidence": [ { "id": "Q2KI29", "url": "https://omabrowser.org/oma/group/Q2KI29/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GY87-1", "protein_name": "Transmembrane protein 256 isoform X1", "gene_name": "Tmem256", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVVGAAFRRLGALSGAGALGLASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLAVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDTSIQIVGPVGGSLLILGWLALAF", "length": 113 }, "evidence": [ { "id": "Q2KI29", "url": "https://omabrowser.org/oma/group/Q2KI29/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q55D69-1", "protein_name": "DUF423 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNELWWKIGGVVACSAIISGAYGGHGLKKKVPDVARQEIWKIGQQYHLYHSFALFLVPFSTQQNIVGPMFLSGILLFSGSLYYISLTNRKIKLPPIGGVSFMAGWVILGMTIDKSLFLKN", "length": 120 }, "evidence": [ { "id": "Q2KI29", "url": "https://omabrowser.org/oma/group/Q2KI29/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5F285-1", "protein_name": "Transmembrane protein 256", "gene_name": "Tmem256", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGVGAAFRRLGALSGAGALGLASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPSCRKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQTLGPVGGSLLILGWLALAF", "length": 113 }, "evidence": [ { "id": "Q2KI29", "url": "https://omabrowser.org/oma/group/Q2KI29/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2U0-1", "protein_name": "Transmembrane protein 256", "gene_name": "TMEM256", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPAAAFRRLGALSGAAALGFASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQTLAPAGGTLLLLGWLALAL", "length": 113 }, "evidence": [ { "id": "Q2KI29", "url": "https://omabrowser.org/oma/group/Q2KI29/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KI29", "url": "https://www.uniprot.org/uniprotkb/Q2KI29" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI29-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 113, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI29-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI29" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI49-1", "uniprot_ac": "Q2KI49", "uniprot_id": "RM50_BOVIN", "mass": { "chemical_mass": 18067.0, "monoisotopic_mass": 18067.0 }, "refseq": { "ac": "NP_001039645", "name": "large ribosomal subunit protein mL50", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" }, "gene_names": [ { "name": "MRPL50", "type": "recommended", "evidence": [ { "id": "Q2KI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI49" } ] }, { "name": "MRPL50", "type": "synonym", "evidence": [ { "id": "NP_001039645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL50", "type": "recommended", "evidence": [ { "id": "Q2KI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI49/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L50, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001039645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" }, { "id": "Q2KI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI49/entry#names_and_taxonomy" } ] }, { "name": "L50mt", "type": "synonym", "evidence": [ { "id": "NP_001039645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" }, { "id": "Q2KI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI49/entry#names_and_taxonomy" } ] }, { "name": "MRP-L50", "type": "synonym", "evidence": [ { "id": "NP_001039645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" }, { "id": "Q2KI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI49/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL50", "type": "synonym", "evidence": [ { "id": "NP_001039645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI49", "url": "https://www.uniprot.org/uniprotkb/Q2KI49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL50", "url": "https://www.uniprot.org/uniprotkb/Q2KI49", "locus": { "chromosome": "8", "start_pos": 91085972, "end_pos": 91120719, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008962", "url": "https://www.ensembl.org/id/ENSBTAG00000008962" } ] } } ], "crossref": [ { "id": "Q2KI49", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514753", "url": "https://www.ncbi.nlm.nih.gov/gene/514753", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514753", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514753", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMCSAQD", "url": "https://omabrowser.org/oma/group/LMCSAQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI49", "url": "https://www.orthodb.org/?gene=Q2KI49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31542", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31542", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31542:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31542:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI49", "url": "https://www.uniprot.org/uniprotkb/Q2KI49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI49-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALWVAGVGRKSLTVVASGAPRREFWSRLRKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRVRDVLDFYTVPVQDRSKFDELIASNLPPNLKITWGY", "length": 159, "header": "sp|Q2KI49-1|RM50_BOVIN Isoform 1 of Large ribosomal subunit protein mL50 OS=Bos taurus OX=9913 GN=MRPL50 PE=1 SV=1 CANONICAL=Q2KI49-1" }, "isoforms": [ { "isoform_ac": "Q2KI49-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI49/entry#Q2KI49-1", "sequence": { "sequence": "MAALWVAGVGRKSLTVVASGAPRREFWSRLRKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRVRDVLDFYTVPVQDRSKFDELIASNLPPNLKITWGY", "length": 159, "header": "sp|Q2KI49-1|RM50_BOVIN Isoform 1 of Large ribosomal subunit protein mL50 OS=Bos taurus OX=9913 GN=MRPL50 PE=1 SV=1 CANONICAL=Q2KI49-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q2KI49", "url": "https://www.uniprot.org/uniprotkb/Q2KI49" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] } ], "pathway": [ { "id": "bta:514753", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514753", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I2Z5-1", "protein_name": "Large ribosomal subunit protein mL50", "gene_name": "Mrpl50", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAALCVCRFAGRGWLWKAPLATRRDFWSRSRKEKEPEVPETVEEVKKEPVLVCPPLRSRSYTPPDGLQSRLESRIKEVLGSSLPSNWQDISLDDSHVKFRLLAHLADDLGHAVPNSRLHQMCRVRDVLDFYSVPVQDRSKFDELIASNLPPNLKISWGY", "length": 159 }, "evidence": [ { "id": "Q2KI49", "url": "https://omabrowser.org/oma/group/Q2KI49/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ZLC1-1", "protein_name": "Large ribosomal subunit protein mL50", "gene_name": "MRPL50", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAIGLRVVGRRLGLGLGRTPRRALWGGHSKKEEKEVEENSIIPQEKKEPSLICPPPRSRKYVPPENIQSILEARVKEICGPSLAGNWLQTSLKDNRLKYQLLAQLAAELGHAVPNSQLHLMCSAQDVLTFYSTPVKDMLKFDELCAAELPPNLKIAWER", "length": 161 }, "evidence": [ { "id": "Q2KI49", "url": "https://omabrowser.org/oma/group/Q2KI49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8N5N7-1", "protein_name": "Large ribosomal subunit protein mL50", "gene_name": "MRPL50", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARSVSGITRRVFMWTVSGTPCREFWSRFRKEKEPVVVETVEEKKEPILVCPPLRSRAYTPPEDLQSRLESYVKEVFGSSLPSNWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY", "length": 158 }, "evidence": [ { "id": "Q2KI49", "url": "https://omabrowser.org/oma/group/Q2KI49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VDT9-1", "protein_name": "Large ribosomal subunit protein mL50", "gene_name": "Mrpl50", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALIVSRLARRGWLWKLPLATRREFWSRSRKEKEPVVAETVEEVKKEPVLVCPPLRSRAYTPPSDLQSRLESHIKEVLGSSLPNNWQDISLDDGHMKFRLLAGLADGLGHAVPNSRLHQMCRVRDVLDFYNVPVQDKSKFDELVASNLPPNLKISWSY", "length": 159 }, "evidence": [ { "id": "Q2KI49", "url": "https://omabrowser.org/oma/group/Q2KI49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q2KI49", "url": "https://www.uniprot.org/uniprotkb/Q2KI49" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2KI49", "url": "https://www.uniprot.org/uniprotkb/Q2KI49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KI52-1", "uniprot_ac": "Q2KI52", "uniprot_id": "HYLS1_BOVIN", "mass": { "chemical_mass": 36196.0, "monoisotopic_mass": 36196.0 }, "refseq": { "ac": "NP_001039904", "name": "centriolar and ciliogenesis-associated protein HYLS1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904" }, "gene_names": [ { "name": "HYLS1", "type": "recommended", "evidence": [ { "id": "Q2KI52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ] }, { "name": "HYLS1", "type": "synonym", "evidence": [ { "id": "NP_001039904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904" } ] } ], "protein_names": [ { "name": "Centriolar and ciliogenesis-associated protein HYLS1", "type": "recommended", "evidence": [ { "id": "Q2KI52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI52/entry#names_and_taxonomy" } ] }, { "name": "Hydrolethalus syndrome protein 1 homolog", "type": "synonym", "evidence": [ { "id": "Q2KI52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI52/entry#names_and_taxonomy" } ] }, { "name": "centriolar and ciliogenesis-associated protein HYLS1", "type": "synonym", "evidence": [ { "id": "NP_001039904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904" } ] }, { "name": "hydrolethalus syndrome 1", "type": "synonym", "evidence": [ { "id": "NP_001039904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904" } ] }, { "name": "hydrolethalus syndrome protein 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904" } ] } ], "function": [ { "annotation": "Plays a role in ciliogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52#function" }, { "database": "UniProtKB", "id": "A0A1L8ER70", "url": "https://www.uniprot.org/uniprotkb/A0A1L8ER70#function" }, { "database": "UniProtKB", "id": "Q95X94", "url": "https://www.uniprot.org/uniprotkb/Q95X94#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HYLS1", "url": "https://www.uniprot.org/uniprotkb/Q2KI52", "locus": { "chromosome": "29", "start_pos": 29257634, "end_pos": 29255004, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010859", "url": "https://www.ensembl.org/id/ENSBTAG00000010859" } ] } } ], "crossref": [ { "id": "Q2KI52", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI52", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010859", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010859", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538735", "url": "https://www.ncbi.nlm.nih.gov/gene/538735", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027918", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027918", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538735", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538735", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICYLQRE", "url": "https://omabrowser.org/oma/group/ICYLQRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR34174", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34174", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34174:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34174:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15311", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15311", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039904", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI52-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQRRRSFSIGEAVEELVGPDGQKWADMDPEERMLVAAKAFPHICAGHGEGDVRREAQSTLYDPYSKASVTSGKQPAFPAQLHHPHTESNGASEAVSETSQRLRKPVMKRKVLRRKPDGEVLVTDESMISESESGTENDMDVWDLRQRLMNLHFQEDRESPVDVSQKFSLPREYQGISQDQLICYLRREEMGPPAYEQDLIVASRPKSFILPRLDQLSRNRGKVDRVARYFEYKRDWDSMRLPGEDHRKELRWGIREQMLCRAEAQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVMPKKLTSFPLFPS", "length": 314, "header": "sp|Q2KI52-1|HYLS1_BOVIN Isoform 1 of Centriolar and ciliogenesis-associated protein HYLS1 OS=Bos taurus OX=9913 GN=HYLS1 PE=2 SV=1 CANONICAL=Q2KI52-1" }, "isoforms": [ { "isoform_ac": "Q2KI52-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI52/entry#Q2KI52-1", "sequence": { "sequence": "MAQRRRSFSIGEAVEELVGPDGQKWADMDPEERMLVAAKAFPHICAGHGEGDVRREAQSTLYDPYSKASVTSGKQPAFPAQLHHPHTESNGASEAVSETSQRLRKPVMKRKVLRRKPDGEVLVTDESMISESESGTENDMDVWDLRQRLMNLHFQEDRESPVDVSQKFSLPREYQGISQDQLICYLRREEMGPPAYEQDLIVASRPKSFILPRLDQLSRNRGKVDRVARYFEYKRDWDSMRLPGEDHRKELRWGIREQMLCRAEAQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVMPKKLTSFPLFPS", "length": 314, "header": "sp|Q2KI52-1|HYLS1_BOVIN Isoform 1 of Centriolar and ciliogenesis-associated protein HYLS1 OS=Bos taurus OX=9913 GN=HYLS1 PE=2 SV=1 CANONICAL=Q2KI52-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538735", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538735", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ARB0-1", "protein_name": "HYLS1 centriolar and ciliosis associated", "gene_name": "HYLS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTERRRSYSIGEAMEELMGPDGQKRANMDPEERMLAAASAFTRMCAEQGEGDVRREAQAIQYDPYSKASVTPGRRPALPVQLHYPHVESSAPSEAVSEASQRFRKPVMKRKVLRRKPGGEVLVTDESIISESEFGTESDMNVWDLRQRLMNLQFQEDRESSVDISQKFSLPHEYQGVSQDQLVCYLQREEMGPQAYEQDLIVASRPKSFILPRLDQLSRNRGKIDRVARYFEYKRDWDSMRLPGEDHRKELRWGVREQMLCRAEPQPKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVMPKKLPFPLSPS", "length": 313 }, "evidence": [ { "id": "Q2KI52", "url": "https://omabrowser.org/oma/group/Q2KI52/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M6D5-1", "protein_name": "Hydrolethalus syndrome protein 1", "gene_name": "Hyls1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEKRQFYNVEEAMGQLIGPGGQKWANMGPEERMLAAATAFTHICAGQGEGDIRREAQATQYDPYSKASVTSGKRPALPVQLHYPPIRSRVTSSSVSEASQKSRKPVMKRKVLRRKPDGEVLVTDESVISESESGTESEVDLWDLRHRLMNLQFQDGTESLSDAPQKFNLPRDYQGISQEDQLICYLQREEMGPPVYEQDLIVASRPKSFILPRLDQLSRNRGKTDRVARYFEYKRDWDSMRFPGEDHRKELRWNVRGQMLSKTEPQYKPQHVYVPNNYLVPTEKKRSALRWGVRCDLANGVMPKKFPFPLSPS", "length": 314 }, "evidence": [ { "id": "Q2KI52", "url": "https://omabrowser.org/oma/group/Q2KI52/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0L3R2-1", "protein_name": "HYLS1, centriolar and ciliogenesis associated", "gene_name": "Hyls1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEKRQAYSVEEAMEQLKGPGGQKWSNMDPEERMLAAATAFTHICAGQGEGDSRREVQAGQYDPYSKASITPGKRAALPMHLHFPYTGSHVTSSTVSETSQKCRKPVMKRKVLRRKPDGEVLVTDESIISESESGTESDLDLWDLRHRLMNLQFQEGTASPVDTSQKLNLPCEYQGISQDQLICYLQREEMGPPVYEQDLIVASRPKSFILPRLDQLSRNRGKIDRVARYFEYKRDWDSMRFPGEDNRKELRWSVRGQMLSRPEPQSKPQHLYVPNSYLVPTEKKRSALRWGVRCDLANGVIPKKLPFPLSPS", "length": 313 }, "evidence": [ { "id": "Q2KI52", "url": "https://omabrowser.org/oma/group/Q2KI52/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96M11-1", "protein_name": "Centriolar and ciliogenesis-associated protein HYLS1", "gene_name": "HYLS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEELLPDGQIWANMDPEERMLAAATAFTHICAGQGEGDVRREAQSIQYDPYSKASVAPGKRPALPVQLQYPHVESNVPSETVSEASQRLRKPVMKRKVLRRKPDGEVLVTDESIISESESGTENDQDLWDLRQRLMNVQFQEDKESSFDVSQKFNLPHEYQGISQDQLICSLQREGMGSPAYEQDLIVASRPKSFILPKLDQLSRNRGKTDRVARYFEYKRDWDSIRLPGEDHRKELRWGVREQMLCRAEPQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVIPRKLPFPLSPS", "length": 299 }, "evidence": [ { "id": "Q2KI52", "url": "https://omabrowser.org/oma/group/Q2KI52/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXX0-1", "protein_name": "Centriolar and ciliogenesis-associated protein HYLS1", "gene_name": "Hyls1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEKRQAYSVPEAMKQLIGPGGQKWANMDPEERMLAAATAFTRICAGQGEGDSRREAQAGQYDPYSKASVTPGKRPALPMHLHFPHTASRVTSSTVSETSQKCRKPVMKRKVLRRKPDGEVLVTDESVISECESGTESDLGLWDLRHRFMNLQFQEGTESPVVTSQKFNLPCEYQGISQEDQLICYLQREEMDPPVYEQDLIVASRPKSFILPRLDQLSRNRGKIDRVARYFEYKRDWDSMRFPGEDHRKELRWSVRGQMLSRTEPPSKPQHVYVPNNYLVPLRWGVRCDLANGVMPKKLPFPLSPS", "length": 307 }, "evidence": [ { "id": "Q2KI52", "url": "https://omabrowser.org/oma/group/Q2KI52/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q2KI52", "url": "https://www.uniprot.org/uniprotkb/Q2KI52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI52-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI52-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI52" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI54-1", "uniprot_ac": "Q2KI54", "uniprot_id": "ARMC8_BOVIN", "mass": { "chemical_mass": 75451.0, "monoisotopic_mass": 75451.0 }, "refseq": { "ac": "NP_001039923", "name": "armadillo repeat-containing protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039923" }, "gene_names": [ { "name": "ARMC8", "type": "recommended", "evidence": [ { "id": "Q2KI54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ] }, { "name": "ARMC8", "type": "synonym", "evidence": [ { "id": "NP_001039923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039923" } ] } ], "protein_names": [ { "name": "Armadillo repeat-containing protein 8", "type": "recommended", "evidence": [ { "id": "Q2KI54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#names_and_taxonomy" } ] }, { "name": "armadillo repeat-containing protein 8", "type": "synonym", "evidence": [ { "id": "NP_001039923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039923" } ] } ], "function": [ { "annotation": "Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP0#function" }, { "database": "UniProtKB", "id": "ARBA00060164", "url": "https://www.uniprot.org/uniprotkb/ARBA00060164#function" }, { "database": "UniProtKB", "id": "A0AAF7AAT7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAT7#function" }, { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54#function" }, { "database": "UniProtKB", "id": "Q8IUR7", "url": "https://www.uniprot.org/uniprotkb/Q8IUR7#function" }, { "database": "UniProtKB", "id": "A0A3Q1M5G7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G7#function" }, { "database": "UniProtKB", "id": "A0A3Q1MCZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCZ7#function" }, { "database": "UniProtKB", "id": "A0A452DIZ5", "url": "https://www.uniprot.org/uniprotkb/A0A452DIZ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARMC8", "url": "https://www.uniprot.org/uniprotkb/Q2KI54", "locus": { "chromosome": "1", "start_pos": 130823745, "end_pos": 130930780, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019952", "url": "https://www.ensembl.org/id/ENSBTAG00000019952" } ] } } ], "crossref": [ { "id": "Q2KI54", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI54", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019952", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019952", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539591", "url": "https://www.ncbi.nlm.nih.gov/gene/539591", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539591", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539591", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWP0", "url": "https://www.orthodb.org/?gene=A0A3Q1LWP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5G7", "url": "https://www.orthodb.org/?gene=A0A3Q1M5G7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCZ7", "url": "https://www.orthodb.org/?gene=A0A3Q1MCZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIZ5", "url": "https://www.orthodb.org/?gene=A0A452DIZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KI54", "url": "https://www.orthodb.org/?gene=Q2KI54", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15651", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15651", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15651:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15651:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9861718", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9861718", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039923", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5G7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5G7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIZ5", "url": "https://www.uniprot.org/uniprotkb/A0A452DIZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAT7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI54-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 673, "header": "sp|Q2KI54-1|ARMC8_BOVIN Isoform 1 of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=2 SV=1 CANONICAL=Q2KI54-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWP0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0A3Q1LWP0-1", "sequence": { "sequence": "KEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 659, "header": "tr|A0A3Q1LWP0-1|A0A3Q1LWP0_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=2 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130929840, "end_pos": 130824405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070152.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070152.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059866.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059866.2" } ] } }, { "isoform_ac": "A0A3Q1M5G7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0A3Q1M5G7-1", "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQGHSHVKLQLAAMFCISNLVWNEEEGKRLVRFVLKKNYGEEGVKQEWHQLPQNPG", "length": 629, "header": "tr|A0A3Q1M5G7-1|A0A3Q1M5G7_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=2 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130930767, "end_pos": 130829856, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072810.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072810.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063516.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063516.2" } ] } }, { "isoform_ac": "A0A3Q1MCZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0A3Q1MCZ7-1", "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 642, "header": "tr|A0A3Q1MCZ7-1|A0A3Q1MCZ7_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=1 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130930767, "end_pos": 130824405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072796.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072796.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066688.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066688.1" } ] } }, { "isoform_ac": "A0A452DIZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0A452DIZ5-1", "sequence": { "sequence": "LFCWQITASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDK", "length": 652, "header": "tr|A0A452DIZ5-1|A0A452DIZ5_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=2 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130900072, "end_pos": 130828503, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026578.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026578.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026578.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026578.7" } ] } }, { "isoform_ac": "A0AAA9SMJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0AAA9SMJ8-1", "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 606, "header": "tr|A0AAA9SMJ8-1|A0AAA9SMJ8_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=1 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130930767, "end_pos": 130824405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126238.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126238.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085170.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085170.1" } ] } }, { "isoform_ac": "A0AAF7AAT7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#A0AAF7AAT7-1", "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMMRKLSTEWLNSLPKNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 687, "header": "tr|A0AAF7AAT7-1|A0AAF7AAT7_BOVIN Computationally mapped isoform of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=4 SV=1 CANONICAL=Q2KI54-1" }, "locus": { "chromosome": "1", "start_pos": 130930767, "end_pos": 130824405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070490.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070490.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065769.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065769.2" } ] } }, { "isoform_ac": "Q2KI54-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI54/entry#Q2KI54-1", "sequence": { "sequence": "MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKTALQQYLA", "length": 673, "header": "sp|Q2KI54-1|ARMC8_BOVIN Isoform 1 of Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=2 SV=1 CANONICAL=Q2KI54-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 337, "end_pos": 337, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "site_lbl": "Ser337" }, { "start_pos": 512, "end_pos": 512, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "site_lbl": "Ser512" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539591", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539591", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-9861718", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9861718", "resource": "Reactome", "description": "Regulation of pyruvate metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" }, { "name": "GID complex", "id": "GO:0034657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034657", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q2KI54", "url": "https://www.uniprot.org/uniprotkb/Q2KI54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI54-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 673, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI54-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI54" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 337, 512 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI75-1", "uniprot_ac": "Q2KI75", "uniprot_id": "KT222_BOVIN", "mass": { "chemical_mass": 34263.0, "monoisotopic_mass": 34263.0 }, "refseq": { "ac": "NP_001421938", "name": "keratin-like protein KRT222 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" }, "gene_names": [ { "name": "KRT222", "type": "recommended", "evidence": [ { "id": "Q2KI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI75" } ] }, { "name": "KA21", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] }, { "name": "KRT222P", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] }, { "name": "KRT222", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] } ], "protein_names": [ { "name": "Keratin-like protein KRT222", "type": "recommended", "evidence": [ { "id": "Q2KI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI75/entry#names_and_taxonomy" } ] }, { "name": "Keratin-222", "type": "synonym", "evidence": [ { "id": "Q2KI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI75/entry#names_and_taxonomy" } ] }, { "name": "keratin 222 pseudogene", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] }, { "name": "keratin-like protein KRT222 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] }, { "name": "keratin-like protein KRT222", "type": "synonym", "evidence": [ { "id": "NP_001421938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI75", "url": "https://www.uniprot.org/uniprotkb/Q2KI75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT222", "url": "https://www.uniprot.org/uniprotkb/Q2KI75", "locus": { "chromosome": "19", "start_pos": 40860957, "end_pos": 40870069, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030539", "url": "https://www.ensembl.org/id/ENSBTAG00000030539" } ] } } ], "crossref": [ { "id": "Q2KI75", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030539", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030539", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509747", "url": "https://www.ncbi.nlm.nih.gov/gene/509747", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509747", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509747", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EEGCLHT", "url": "https://omabrowser.org/oma/group/EEGCLHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI75", "url": "https://www.orthodb.org/?gene=Q2KI75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47082:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47082:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421938", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI75", "url": "https://www.uniprot.org/uniprotkb/Q2KI75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI75-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELSQLLNEIRANYEKLLTRNQIETVLSTRIQLEEDLSKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERGLENSLHASEQHYQMQLQDLEAVIEGLEKELQEVRRGIERQLQEHEMLLNTKMRLEQEIATYRRLLEKEEIRYYGSIQGGKKEQKPTTSRVGFVLPSAIINEISFSTKVPQKYEDEKVETVTKQAILNGNIVKESTEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCSQTKQDNLPDIEVRLIMRRSCSIPSIKRPSTTN", "length": 295, "header": "sp|Q2KI75-1|KT222_BOVIN Isoform 1 of Keratin-like protein KRT222 OS=Bos taurus OX=9913 GN=KRT222 PE=2 SV=1 CANONICAL=Q2KI75-1" }, "isoforms": [ { "isoform_ac": "Q2KI75-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI75/entry#Q2KI75-1", "sequence": { "sequence": "MELSQLLNEIRANYEKLLTRNQIETVLSTRIQLEEDLSKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERGLENSLHASEQHYQMQLQDLEAVIEGLEKELQEVRRGIERQLQEHEMLLNTKMRLEQEIATYRRLLEKEEIRYYGSIQGGKKEQKPTTSRVGFVLPSAIINEISFSTKVPQKYEDEKVETVTKQAILNGNIVKESTEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCSQTKQDNLPDIEVRLIMRRSCSIPSIKRPSTTN", "length": 295, "header": "sp|Q2KI75-1|KT222_BOVIN Isoform 1 of Keratin-like protein KRT222 OS=Bos taurus OX=9913 GN=KRT222 PE=2 SV=1 CANONICAL=Q2KI75-1" }, "locus": { "chromosome": "19", "start_pos": 40869991, "end_pos": 40862102, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043110.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043110.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040702.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040702.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509747", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509747", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZXJ0-1", "protein_name": "Keratin 222", "gene_name": "KRT222", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELSQLLNEIRANYEKLLTRNQIETVLSTRIQLEEDLSKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERGLENSLHASEQHYQMQLQDLEAVIEGLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRRLLEKEEIRYYGCIQGGKKEQKPTTSRVGFVLPSAIINEISFSTKVPQKYENEKVETVTKQAILNGSIVKESTEAHGTIQTERVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLQTKQDNLPDIEVRLIMRRSCSIPSIKPPSAAN", "length": 295 }, "evidence": [ { "id": "Q2KI75", "url": "https://omabrowser.org/oma/group/Q2KI75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZX31-1", "protein_name": "Keratin 222", "gene_name": "KRT222", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAARLLGGRGAKYETPDTRNQIRSAVAARTQQEATPIKRMDKDAEALQAARAELSEARRQWHHMQSEIESLHAVEKGLERSLRATEQQYHVQLQNLEAEIECLEKDLQEVRRGIEKQLREHEILLNTRMKLEEEIATYRSLLEQEENRYRCSISEQKGRKPTLNTTAFMLPADGIKKHETEKIELMTKQAILEGNIMKQSAEAHGTIKTEKVDEVIKQWEGSFFKDNPRLRKKSVSLRFDLHLAAAEEGCIPSQQKALPAIEVRLVMRRSCSIPSIKP", "length": 279 }, "evidence": [ { "id": "Q2KI75", "url": "https://omabrowser.org/oma/group/Q2KI75/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4AC62-1", "protein_name": "Keratin 222", "gene_name": "Krt222", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELSQLLNEIRANYEQLLTRNQIDTVLSTRIQLEEDLTKKMDKDGEALKAAQAELKEARRQCHHLQVEIESLHAVERGLENSLQASEQHYQMQLQDLESVIGRLEKELQEVRRGIERQLQEHEMLLNTKMRLEQEIATYRRLLEQEEIRYYGCIQGERKEDKPAKSKVGFLLPSAIINEISFSTKVSHKYENESVETVTKQAVVNGDVAKESAEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLESRQDNLPDIEVRLIMRRSCSIPSIKPPPGTN", "length": 295 }, "evidence": [ { "id": "Q2KI75", "url": "https://omabrowser.org/oma/group/Q2KI75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CCX5-1", "protein_name": "Keratin-like protein KRT222", "gene_name": "Krt222", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELSQLLNEIRANYEQLLTRNQIETVLSTRIQLEEDITKKMDKDGEALKAAQAELKEARRQCHHLQVEIESLHAVERGLENSLQASEQHYQMQLQDLESVIGRLERELQEVRRGIERQLREHEMLLNTKMRLEQEIATYRRLLEQEEIRYYGCIQGEKKEEKPTKSKVGFLLPSAIINEISFSTKVSQKYENENMETVTKQAVVNRDVKESAEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLESRQDNLPDIEVRLIMRRSCSIPSIKPPPGTN", "length": 294 }, "evidence": [ { "id": "Q2KI75", "url": "https://omabrowser.org/oma/group/Q2KI75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N1A0-1", "protein_name": "Keratin-like protein KRT222", "gene_name": "KRT222", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSQLLNEIRANYEKILTRNQIETVLSTRIQLEEDISKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERGLENSLHASEQHYQMQLQDLETVIEGLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRHLLEKEEIRYYGCIQGGKKDKKPTTSRVGFVLPSAIINEISFTTKVPQKYENENVETVTKQAILNGSIVKESTEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLETKQDNLPDIEVRLIMRRSCSIPSIKPPSTAN", "length": 295 }, "evidence": [ { "id": "Q2KI75", "url": "https://omabrowser.org/oma/group/Q2KI75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "Q2KI75", "url": "https://www.uniprot.org/uniprotkb/Q2KI75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q2KI75", "url": "https://www.uniprot.org/uniprotkb/Q2KI75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI75" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI75" }, { "id": "PRU01188", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 150, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI79-1", "uniprot_ac": "Q2KI79", "uniprot_id": "ANRA2_BOVIN", "mass": { "chemical_mass": 34159.0, "monoisotopic_mass": 34159.0 }, "refseq": { "ac": "NP_001039754", "name": "ankyrin repeat family A protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" }, "gene_names": [ { "name": "ANKRA2", "type": "recommended", "evidence": [ { "id": "Q2KI79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ] }, { "name": "ANKRA2", "type": "synonym", "evidence": [ { "id": "NP_001039754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" } ] } ], "protein_names": [ { "name": "Ankyrin repeat family A protein 2", "type": "recommended", "evidence": [ { "id": "Q2KI79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI79/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat family A protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" } ] }, { "name": "ankyrin repeat, family A (RFXANK-like), 2", "type": "synonym", "evidence": [ { "id": "NP_001039754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" } ] } ], "function": [ { "annotation": "May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79#function" }, { "database": "UniProtKB", "id": "Q9H9E1", "url": "https://www.uniprot.org/uniprotkb/Q9H9E1#function" }, { "database": "UniProtKB", "id": "A2ARV4", "url": "https://www.uniprot.org/uniprotkb/A2ARV4#function" } ] }, { "annotation": "The findings of association in different populations with different SNPs support a conclusion that variation close to the ANKRA2/CD180 locus analysed in this study contributes to differential response to pathogen exposure.", "evidence": [ { "database": "RefSeq", "id": "NP_001039754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" }, { "database": "PubMed", "id": "22034997", "url": "https://glygen.org/publication/PubMed/22034997" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRA2", "url": "https://www.uniprot.org/uniprotkb/Q2KI79", "locus": { "chromosome": "20", "start_pos": 8081268, "end_pos": 8070928, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018452", "url": "https://www.ensembl.org/id/ENSBTAG00000018452" } ] } } ], "crossref": [ { "id": "Q2KI79", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018452", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018452", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528003", "url": "https://www.ncbi.nlm.nih.gov/gene/528003", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528003", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528003", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FKAECSI", "url": "https://omabrowser.org/oma/group/FKAECSI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI79", "url": "https://www.orthodb.org/?gene=Q2KI79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI79-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSANLDIGAQLIVEECPSSYSLSGMPDIKIEHQPDSSAEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE", "length": 313, "header": "sp|Q2KI79-1|ANRA2_BOVIN Isoform 1 of Ankyrin repeat family A protein 2 OS=Bos taurus OX=9913 GN=ANKRA2 PE=2 SV=1 CANONICAL=Q2KI79-1" }, "isoforms": [ { "isoform_ac": "Q2KI79-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI79/entry#Q2KI79-1", "sequence": { "sequence": "MATSANLDIGAQLIVEECPSSYSLSGMPDIKIEHQPDSSAEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE", "length": 313, "header": "sp|Q2KI79-1|ANRA2_BOVIN Isoform 1 of Ankyrin repeat family A protein 2 OS=Bos taurus OX=9913 GN=ANKRA2 PE=2 SV=1 CANONICAL=Q2KI79-1" }, "locus": { "chromosome": "20", "start_pos": 8080803, "end_pos": 8073307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024557.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024557.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024557.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024557.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Association of single nucleotide polymorphisms in the ANKRA2 and CD180 genes with bovine respiratory disease and presence of Mycobacterium avium subsp. paratuberculosis(1).", "journal": "Animal genetics", "date": "2011-12", "authors": "Casas E, Garcia M D, Wells J E, Smith T P L", "evidence": [ { "database": "RefSeq", "id": "NP_001039754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039754" } ], "reference": [ { "type": "PubMed", "id": "22034997", "url": "https://glygen.org/publication/PubMed/22034997" } ] } ], "pathway": [ { "id": "bta:528003", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528003", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I5I3-1", "protein_name": "Ankyrin repeat family A protein 2 isoform X1", "gene_name": "Ankra2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATSANLDIGAQLIVEECPSSYSLSDMPDIKIEHQLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE", "length": 313 }, "evidence": [ { "id": "Q2KI79", "url": "https://omabrowser.org/oma/group/Q2KI79/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S2K0-1", "protein_name": "Ankyrin repeat family A member 2", "gene_name": "ANKRA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASSANLDIGAQLIVEECPSGYGLTGMPDIKIEHQLDSNAEEGPAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE", "length": 313 }, "evidence": [ { "id": "Q2KI79", "url": "https://omabrowser.org/oma/group/Q2KI79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9H9E1-1", "protein_name": "Ankyrin repeat family A protein 2", "gene_name": "ANKRA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE", "length": 313 }, "evidence": [ { "id": "Q2KI79", "url": "https://omabrowser.org/oma/group/Q2KI79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "3M complex", "id": "GO:1990393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990393", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor binding", "id": "GO:0050750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050750", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" }, { "name": "regulation of protein-containing complex assembly", "id": "GO:0043254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043254", "evidence": [ { "database": "UniProtKB", "id": "Q2KI79", "url": "https://www.uniprot.org/uniprotkb/Q2KI79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI79-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI79-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI79" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KI83-1", "uniprot_ac": "Q2KI83", "uniprot_id": "DJC17_BOVIN", "mass": { "chemical_mass": 34572.0, "monoisotopic_mass": 34572.0 }, "refseq": { "ac": "NP_001039741", "name": "dnaJ homolog subfamily C member 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741" }, "gene_names": [ { "name": "DNAJC17", "type": "recommended", "evidence": [ { "id": "Q2KI83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ] }, { "name": "DNAJC17", "type": "synonym", "evidence": [ { "id": "NP_001039741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 17", "type": "recommended", "evidence": [ { "id": "Q2KI83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI83/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 17", "type": "synonym", "evidence": [ { "id": "NP_001039741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741" } ] }, { "name": "DnaJ homolog, subfamily C, member 17", "type": "synonym", "evidence": [ { "id": "NP_001039741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741" } ] }, { "name": "dnaJ homolog subfamily C member 17", "type": "synonym", "evidence": [ { "id": "NP_001039741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741" } ] } ], "function": [ { "annotation": "May negatively affect PAX8-induced thyroglobulin/TG transcription.", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83#function" }, { "database": "UniProtKB", "id": "Q91WT4", "url": "https://www.uniprot.org/uniprotkb/Q91WT4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC17", "url": "https://www.uniprot.org/uniprotkb/Q2KI83", "locus": { "chromosome": "10", "start_pos": 36316703, "end_pos": 36347349, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013480", "url": "https://www.ensembl.org/id/ENSBTAG00000013480" } ] } } ], "crossref": [ { "id": "Q2KI83", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI83", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013480", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013480", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12429", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12429", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524795", "url": "https://www.ncbi.nlm.nih.gov/gene/524795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524795", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NPLHFQW", "url": "https://omabrowser.org/oma/group/NPLHFQW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KI83", "url": "https://www.orthodb.org/?gene=Q2KI83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44313:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44313:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039741", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI83-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAEDKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQKLDERRKKVKLDLEARERQAQALGSEEEEESGSARTLEQEIERLREEGSRQLEEQQRLIREQIRQEQEQRLTGMAKNPENKETPKLKLKWKSKKEAESQGGYSRDVLLQLFQKYGEVLNLVLSSKKAGTAVVEFATVKAAELAVQNEVGLVDNPLKISWLEGRPQSAMGHNHPGLSRGSVVSERDYESLVMMRMRQAAERQQLIAQMQQEDQAGQPT", "length": 304, "header": "sp|Q2KI83-1|DJC17_BOVIN Isoform 1 of DnaJ homolog subfamily C member 17 OS=Bos taurus OX=9913 GN=DNAJC17 PE=2 SV=1 CANONICAL=Q2KI83-1" }, "isoforms": [ { "isoform_ac": "Q2KI83-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI83/entry#Q2KI83-1", "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAEDKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQKLDERRKKVKLDLEARERQAQALGSEEEEESGSARTLEQEIERLREEGSRQLEEQQRLIREQIRQEQEQRLTGMAKNPENKETPKLKLKWKSKKEAESQGGYSRDVLLQLFQKYGEVLNLVLSSKKAGTAVVEFATVKAAELAVQNEVGLVDNPLKISWLEGRPQSAMGHNHPGLSRGSVVSERDYESLVMMRMRQAAERQQLIAQMQQEDQAGQPT", "length": 304, "header": "sp|Q2KI83-1|DJC17_BOVIN Isoform 1 of DnaJ homolog subfamily C member 17 OS=Bos taurus OX=9913 GN=DNAJC17 PE=2 SV=1 CANONICAL=Q2KI83-1" }, "locus": { "chromosome": "10", "start_pos": 36347337, "end_pos": 36316775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017926.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017926.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017926.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017926.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 112, "end_pos": 112, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "site_lbl": "Ser112" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524795", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524795", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZSC8-1", "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dnajc17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKARKQAAERTQRLDEKRKKVKLDLEARERQAQAQGTEEEEESRSTTTLEQEIARLREEGSRQLEEQQRLIQEQIRQDREQRLRGRTENTEGKGTPKLKLKWKCKKEDESQGGYSRDILLRLLQKYGEVLNLVLSKKKAGNAIVEFATVRAAELAVRNEVGLADNPLKVSWLEGQPQGTVDPSPPGLSKGSVLSERDYESLVMMRMRQAAERQQLIAQMQQEDEGRPT", "length": 303 }, "evidence": [ { "id": "Q2KI83", "url": "https://omabrowser.org/oma/group/Q2KI83/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HYR8-1", "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dnajc17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALAVLTDAAARAAYDKVRRAKKQAAERTQRLDEKRKKVKLDLEARERQAQAQGSEEEDESRSTTTLEQEIARLREEGSRQLEEQQRLVQEQIRQDREQRLRGRTENIEGRGTPKLKLKWKCKKEDESLGGYSRDVLLRLLQKYGEVLNLVLSRKKAGNAIVEFASVRAAELAVRNEVGLVDNPLKISWLEGQPQGTVDPSDTGLSKGSVLSERDYESLVMMRMRQAAERQQLIAQMQQEDEGQPT", "length": 303 }, "evidence": [ { "id": "Q2KI83", "url": "https://omabrowser.org/oma/group/Q2KI83/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q91WT4-1", "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dnajc17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQRLDENRKKVKLDLEARERQAQAHGSEEEEESRSATTLEQEIARLREEGSRQLEEQQRLIQEQIRQDREQRLRGRTENTEGKGTPKLKLKWKCKKEDESQGGYSRDVLLRLLQKYGEVLNLVLSRKKAGNAIVEFATVRAAELAVRNEVGLADNPLKVSWLEGQPQSTVDPGPPGLSKGSVLSERDFESLVMMRMRQAAERQQLIAQMQQEDEGRPT", "length": 303 }, "evidence": [ { "id": "Q2KI83", "url": "https://omabrowser.org/oma/group/Q2KI83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVM6-1", "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "DNAJC17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQKLDEKRKKVKLDLEARERQAQAQESEEEEESRSTRTLEQEIERLREEGSRQLEEQQRLIREQIRQERDQRLRGKAENTEGQGTPKLKLKWKCKKEDESKGGYSKDVLLRLLQKYGEVLNLVLSSKKPGTAVVEFATVKAAELAVQNEVGLVDNPLKISWLEGQPQDAVGRSHSGLSKGSVLSERDYESLVMMRMRQAAERQQLIARMQQEDQEGPPT", "length": 304 }, "evidence": [ { "id": "Q2KI83", "url": "https://omabrowser.org/oma/group/Q2KI83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VGR0-1", "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dmel\\CG17187", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASKKYSDVNLYDLLGISLESDQNEIRKAYRKKALECHPDKNPDNPKAVERFHELSKALEILTDESARAAYDKVLKAKKAAELRSRQLDGKRQKLKLELEERERAALHKLAKSQPYSTVAKSDEEVLHEQIERLRREGSRLLEEEQRAMQEQFRRNHAEQQKLQQQPVQFDSAQHRIKMKWKAEPGQDYTQQELLKYLKKYGDVVALVVNSKRRGRAMVELATREACDMVLAYEKGDPAKPLHFEWVTPPAADKQTTKSATTGCSASSTDYEDLVMRKLRQAEERKRLIEQMMKDEEGE", "length": 299 }, "evidence": [ { "id": "Q2KI83", "url": "https://omabrowser.org/oma/group/Q2KI83/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "pmid": "" }, { "name": "spliceosomal complex disassembly", "id": "GO:0000390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000390", "evidence": [ { "database": "UniProtKB", "id": "Q2KI83", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI83-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 304, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI83-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI83" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KI83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 76, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KI83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI83" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 178, "end_pos": 249, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 112 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KI85-1", "uniprot_ac": "Q2KI85", "uniprot_id": "SMTL2_BOVIN", "mass": { "chemical_mass": 49814.0, "monoisotopic_mass": 49814.0 }, "refseq": { "ac": "NP_001039785", "name": "smoothelin-like protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039785" }, "gene_names": [ { "name": "SMTNL2", "type": "recommended", "evidence": [ { "id": "Q2KI85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ] }, { "name": "SMTNL2", "type": "synonym", "evidence": [ { "id": "NP_001039785", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039785" } ] } ], "protein_names": [ { "name": "Smoothelin-like protein 2", "type": "recommended", "evidence": [ { "id": "Q2KI85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI85/entry#names_and_taxonomy" } ] }, { "name": "smoothelin-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039785", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039785" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMTNL2", "url": "https://www.uniprot.org/uniprotkb/Q2KI85", "locus": { "chromosome": "19", "start_pos": 25091270, "end_pos": 25113235, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020605", "url": "https://www.ensembl.org/id/ENSBTAG00000020605" } ] } } ], "crossref": [ { "id": "Q2KI85", "url": "https://alphafold.ebi.ac.uk/entry/Q2KI85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020605", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020605", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21261", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21261", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532143", "url": "https://www.ncbi.nlm.nih.gov/gene/532143", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532143", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532143", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "APHQGER", "url": "https://omabrowser.org/oma/group/APHQGER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAS7", "url": "https://www.orthodb.org/?gene=A0A3Q1MAS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ10", "url": "https://www.orthodb.org/?gene=A0A452DJ10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KI85", "url": "https://www.orthodb.org/?gene=Q2KI85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039785", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ10", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ10-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KI85-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESAPDAEEARTVREALGRYEAALEGAVRALHEDMQGLQRGVEQRVAEALRLAGPLARTVAELQRDNQRLQTQLERLTRQVESLGLTTGLAPAPGTPSPPPAPGVPNRAPRLGTARFASHATFSLSGRSQSLDHHDEASELEMRRTSNSCIIENGHQPGADPGDGPPEATQTIPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSATALSPTSAAILGGLSSSPSEATTPWTPSPSEKNSSLPRSLSSSGFGAMTASRNNNSPPLVTPPQSPPSPQPPATTQAHRPGERRRELVRSQTLPRTSGAQARKALFEKWEQDTAGKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRRQNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 458, "header": "sp|Q2KI85-1|SMTL2_BOVIN Isoform 1 of Smoothelin-like protein 2 OS=Bos taurus OX=9913 GN=SMTNL2 PE=2 SV=1 CANONICAL=Q2KI85-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAS7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI85/entry#A0A3Q1MAS7-1", "sequence": { "sequence": "MESAPDAEEARTVREALGRYEAALEGAVRALHEDMQGLQRGVEQRVAEALRLAGPLARTVAELQRDNQRLQTQLERLTRQVESLGLTTGLAPAPGTPSPPPAPGVPNRAPRLGTARFASHATFSLSGRSQSLDHHDEASELEMRRTSNSCIIENGHQPGADPGDGPPEATQTIPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSATALSPTSAAILGGLSSSPSEATTPWTPSPSGRSRRACMASEWEGGPPLVTPPQSPPSPQPPATTQAHRPGERRRELVRSQTLPRTSGAQARKALFEKWEQDTAGKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRRQNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 447, "header": "tr|A0A3Q1MAS7-1|A0A3Q1MAS7_BOVIN Computationally mapped isoform of Smoothelin like 2 OS=Bos taurus OX=9913 GN=SMTNL2 PE=3 SV=1 CANONICAL=Q2KI85-1" }, "locus": { "chromosome": "19", "start_pos": 25112963, "end_pos": 25092091, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067735.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067735.1" } ] } }, { "isoform_ac": "A0A452DJ10-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI85/entry#A0A452DJ10-1", "sequence": { "sequence": "MNPARGGQLRSGAAELDYSLRVRPDLPDKQAPGPAMESAPDAEEARTVREALGRYEAALEGAVRALHEDMQGLQRGVEQRVAEALRLAGPLARTVAELQRDNQRLQTQLERLTRQVESLGLTTGLAPAPGTPSPPPAPGVPNRAPRLGTARFASHATFSLSGRSQSLDHHDEASELEMRRTSNSCIIENGHQPGADPGDGPPEATQTIPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSATALSPTSAAILGGLSSSPSEATTPWTPSPSEKNSSLPRSLSSSGFGAMTASRNNNSPPLVTPPQSPPSPQPPATTQAHRPGERRRELVRSQTLPRTSGAQARKALFEKWEQDTAGKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRRQNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 493, "header": "tr|A0A452DJ10-1|A0A452DJ10_BOVIN Computationally mapped isoform of Smoothelin like 2 OS=Bos taurus OX=9913 GN=SMTNL2 PE=3 SV=1 CANONICAL=Q2KI85-1" }, "locus": { "chromosome": "19", "start_pos": 25113068, "end_pos": 25092091, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027457.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027457.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027457.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027457.4" } ] } }, { "isoform_ac": "Q2KI85-1", "url": "https://www.uniprot.org/uniprotkb/Q2KI85/entry#Q2KI85-1", "sequence": { "sequence": "MESAPDAEEARTVREALGRYEAALEGAVRALHEDMQGLQRGVEQRVAEALRLAGPLARTVAELQRDNQRLQTQLERLTRQVESLGLTTGLAPAPGTPSPPPAPGVPNRAPRLGTARFASHATFSLSGRSQSLDHHDEASELEMRRTSNSCIIENGHQPGADPGDGPPEATQTIPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSATALSPTSAAILGGLSSSPSEATTPWTPSPSEKNSSLPRSLSSSGFGAMTASRNNNSPPLVTPPQSPPSPQPPATTQAHRPGERRRELVRSQTLPRTSGAQARKALFEKWEQDTAGKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRRQNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 458, "header": "sp|Q2KI85-1|SMTL2_BOVIN Isoform 1 of Smoothelin-like protein 2 OS=Bos taurus OX=9913 GN=SMTNL2 PE=2 SV=1 CANONICAL=Q2KI85-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 96, "start_aa": "Thr", "end_pos": 96, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr96", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser126" }, { "start_pos": 131, "end_pos": 131, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser131" }, { "start_pos": 252, "end_pos": 252, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser252" }, { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser254" }, { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser267" }, { "start_pos": 272, "end_pos": 272, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Thr272" }, { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser276" }, { "start_pos": 341, "end_pos": 341, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser341" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Thr96" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532143", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532143", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PRI5-1", "protein_name": "Smoothelin like 2", "gene_name": "SMTNL2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASEIDNLNSHEAKTVCEALGRYEDTLRGAVREIHVDIQVFKQGVSRQVDEVLRLASPLARTVSELQQENQRLRVQLERLARQVEALGRSAGLPQEWQEEAERSPPAVGPSSPVPAFSGDRFSTLAKLAVSGRSQSVDLDDHHKPEFRRVFSSSLIENGHQSSSGQAKASHELTSFYMSDSSPEAHAPAMTLQMPHLPVTAVTRISEKFSGENIHSAGTTNASTGLLGQNQSKNEMTLKTSNQSVRTMTSSANGVNATSVTKPVSTASYEASSGNKTGESAADSYCGMTPKAHSSPPTVHRQVERRRELVRSQTLPRTTGTQARKALFEKFEQDSGKGKGQSRAKLKRSQSFGVASASSIKQILLDWCRSKTIGYKHIDLQNFSSSWNDGMAFCALVHSFFPESFDYNKLDPANRKQNFELAFTMAEKMAHCDRLIEVDDMMMMGHKPDPMCVFTYVQSLYNHLRHFE", "length": 468 }, "evidence": [ { "id": "Q2KI85", "url": "https://omabrowser.org/oma/group/Q2KI85/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZUC1-1", "protein_name": "Smoothelin-like 2", "gene_name": "Smtnl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPTPDAEEAHTVREALGRYEAALEGAVRALHEDMQGLQRGVERRVAEALRLAGPLARTVAELQRDNQRLQAQLERLTRQVEALGLATGVSPAPGTPSPPPATTVTDRAPRLGTARFSSHATFSLSGRSPSMEHDEVSDLEARRTSNSCIMENGHQLDAGSANGSSEVQASSAQESPRPRPVSLSLRLPHQPVTAVTRVSEKFSGETSASALSPTSAAIVGGFTPSPSEAISPWTPSPTEKSSSFTRSLSGSGYGAVTAGKRKDSPPLVTPPQSPPSSQPPAMTQAPRQGERRRELVRSQTLPRTSGAQARKALFEKWEQDTASKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTVGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 456 }, "evidence": [ { "id": "Q2KI85", "url": "https://omabrowser.org/oma/group/Q2KI85/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RGN8-1", "protein_name": "Smoothelin like 2", "gene_name": "SMTNL2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPAPDAEEARTVREALGRYEAALEGAVRALHEDMQGLQRGVEQRVAEALRLAGPLARTVAELQRDNQRLQAQLERLTRQVEALGLATGMAPTPGTPSPPPAPSVPDRAPRLGTARFASHATFSLSGRSQSVDQHDEASGSETRRTSNSCIFENGHQPGAGLGDGPPEAPQTIPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSATALSATSAAKLGSPSEATTPWTPSPSEKNSSLSRSLSTLTASRNNDSSPPLVTPPQSPPSPQPPATTQAHRQGERRRELVRSQTLPRTSGAQARKALFEKWEQDTAGKGRSETRAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRRQNFELAFTMAENLANCERLIEVEDMMLMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 450 }, "evidence": [ { "id": "Q2KI85", "url": "https://omabrowser.org/oma/group/Q2KI85/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2TAL5-1", "protein_name": "Smoothelin-like protein 2", "gene_name": "SMTNL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPAPDAQEARTVREALGRYEAALEGAVRALHEDMRGLQRGVERRVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSPPPAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDEASESEMRKTSNSCIMENGHQPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQPVTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPSEVITPWTPSPSEKNSSFTWSVPSSGYGAVTASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 461 }, "evidence": [ { "id": "Q2KI85", "url": "https://omabrowser.org/oma/group/Q2KI85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CI12-1", "protein_name": "Smoothelin-like protein 2", "gene_name": "Smtnl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPSPDAEEAHTVREALGRYEAALEGAVRALHEDMQGLQRGVERRVAEALRLAGPLARTVAELQRDNQRLQAQLERLTRQVEALGLATGVSPAPGTPSPPPAATVTDRAPRLGTARFSSHATFSLSGRSPSVEHDEASDLEVRRASNSCILENGHQLDAGPANGSSEVQTSSAQEPPRPRPVSLSLRMPHQPVTAVTRVSEKFSGETSASALSPTSAAIVGGFTPSPSEAISPWTPSPTEKSSSFTRSLSGSGYGAVTAGKRKDSPPLVTPPQSPPSSQPPAMTQAPRQGERRRELVRSQTLPRTSGAQARKALFEKWEQDTASKGKGETRAKLKRSQSFGVASASSIKQILLEWCRSKTVGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE", "length": 456 }, "evidence": [ { "id": "Q2KI85", "url": "https://omabrowser.org/oma/group/Q2KI85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q2KI85", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KI85-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 458, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KI85-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KI85" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KI85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI85" }, { "id": "PRU00044", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000255", "start_pos": 348, "end_pos": 455, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 96 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 96, 98, 126, 131, 252, 254, 267, 272, 276, 341 ], "sequon_annotation_sites": [ { "start_pos": 244, "end_pos": 246 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 372, "end_pos": 374 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIB7-1", "uniprot_ac": "Q2KIB7", "uniprot_id": "BORC7_BOVIN", "mass": { "chemical_mass": 11562.0, "monoisotopic_mass": 11562.0 }, "refseq": {}, "gene_names": [ { "name": "BORCS7", "type": "recommended", "evidence": [ { "id": "Q2KIB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7" } ] } ], "protein_names": [ { "name": "BLOC-1-related complex subunit 7", "type": "recommended", "evidence": [ { "id": "Q2KIB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIB7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7#function" }, { "database": "UniProtKB", "id": "Q96B45", "url": "https://www.uniprot.org/uniprotkb/Q96B45#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIB7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BORCS7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7", "locus": { "chromosome": "26", "start_pos": 23496703, "end_pos": 23483985, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061159", "url": "https://www.ensembl.org/id/ENSBTAG00000061159" } ] } } ], "crossref": [ { "id": "Q2KIB7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "613274", "url": "https://www.ncbi.nlm.nih.gov/gene/613274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613274", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613274", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIB7", "url": "https://www.orthodb.org/?gene=Q2KIB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31397:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31397:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2KIB7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIB7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATGTPDSQARFGQSVKGLLTEKVNTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSNLQDQLNHLLK", "length": 105, "header": "sp|Q2KIB7-1|BORC7_BOVIN Isoform 1 of BLOC-1-related complex subunit 7 OS=Bos taurus OX=9913 GN=BORCS7 PE=3 SV=2 CANONICAL=Q2KIB7-1" }, "isoforms": [ { "isoform_ac": "Q2KIB7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7/entry#Q2KIB7-1", "sequence": { "sequence": "MATGTPDSQARFGQSVKGLLTEKVNTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSNLQDQLNHLLK", "length": 105, "header": "sp|Q2KIB7-1|BORC7_BOVIN Isoform 1 of BLOC-1-related complex subunit 7 OS=Bos taurus OX=9913 GN=BORCS7 PE=3 SV=2 CANONICAL=Q2KIB7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613274", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q2KIB7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "Q2KIB7", "url": "https://www.uniprot.org/uniprotkb/Q2KIB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIB7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 105, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIB7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIB7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIC6-1", "uniprot_ac": "Q2KIC6", "uniprot_id": "NRN1_BOVIN", "mass": { "chemical_mass": 15279.0, "monoisotopic_mass": 15279.0 }, "refseq": { "ac": "NP_001039903", "name": "neuritin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039903" }, "gene_names": [ { "name": "NRN1", "type": "recommended", "evidence": [ { "id": "Q2KIC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ] }, { "name": "NRN1", "type": "synonym", "evidence": [ { "id": "NP_001039903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039903" } ] } ], "protein_names": [ { "name": "Neuritin", "type": "recommended", "evidence": [ { "id": "Q2KIC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6/entry#names_and_taxonomy" } ] }, { "name": "neuritin precursor", "type": "synonym", "evidence": [ { "id": "NP_001039903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039903" } ] } ], "function": [ { "annotation": "Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6", "locus": { "chromosome": "23", "start_pos": 48994830, "end_pos": 48986030, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009873", "url": "https://www.ensembl.org/id/ENSBTAG00000009873" } ] } } ], "crossref": [ { "id": "Q2KIC6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538730", "url": "https://www.ncbi.nlm.nih.gov/gene/538730", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538730", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538730", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CAYWEDF", "url": "https://omabrowser.org/oma/group/CAYWEDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIC6", "url": "https://www.orthodb.org/?gene=Q2KIC6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15902:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15902:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIC6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGGGNGAAGPLLPALPVLLVSLSAALATWLSF", "length": 142, "header": "sp|Q2KIC6-1|NRN1_BOVIN Isoform 1 of Neuritin OS=Bos taurus OX=9913 GN=NRN1 PE=2 SV=1 CANONICAL=Q2KIC6-1" }, "isoforms": [ { "isoform_ac": "Q2KIC6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6/entry#Q2KIC6-1", "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGGGNGAAGPLLPALPVLLVSLSAALATWLSF", "length": 142, "header": "sp|Q2KIC6-1|NRN1_BOVIN Isoform 1 of Neuritin OS=Bos taurus OX=9913 GN=NRN1 PE=2 SV=1 CANONICAL=Q2KIC6-1" }, "locus": { "chromosome": "23", "start_pos": 48993971, "end_pos": 48986258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013021.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013021.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013021.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013021.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538730", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538730", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y8T8-1", "protein_name": "Neuritin 1", "gene_name": "NRN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "GSPSPHPQRSPSGALLLLSPCASGVGWARVDGHRAALSAFVLPAWGRGRCHASITSRAGTRGPHRGAVPPSCPPPRLSVRAHALLHGDPASHHPSLRRRLLLPAHLVQAVRAAGRCDAVFRGFSDCLLRLGDNMANYPQDLDDKRNLQTICAYWDDFHACTLTALTDCQEGATDLWEKLRRESKNLDFQGSLFELCGGGSGAAPSLLPPALPVLLGALGAALATWGLPF", "length": 229 }, "evidence": [ { "id": "Q2KIC6", "url": "https://omabrowser.org/oma/group/Q2KIC6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RW81-1", "protein_name": "Neuritin 1", "gene_name": "NRN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPALPVLLVALSAALATWLSF", "length": 142 }, "evidence": [ { "id": "Q2KIC6", "url": "https://omabrowser.org/oma/group/Q2KIC6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08957-1", "protein_name": "Neuritin", "gene_name": "Nrn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPALSVLLVSLSAALATWLSF", "length": 142 }, "evidence": [ { "id": "Q2KIC6", "url": "https://omabrowser.org/oma/group/Q2KIC6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CFV4-1", "protein_name": "Neuritin", "gene_name": "Nrn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSSNGAAGSLLPALSVLLVSLSAALATWFSF", "length": 142 }, "evidence": [ { "id": "Q2KIC6", "url": "https://omabrowser.org/oma/group/Q2KIC6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPD7-1", "protein_name": "Neuritin", "gene_name": "NRN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPAFPVLLVSLSAALATWLSF", "length": 142 }, "evidence": [ { "id": "Q2KIC6", "url": "https://omabrowser.org/oma/group/Q2KIC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "AMPA glutamate receptor complex", "id": "GO:0032281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032281", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuron projection extension", "id": "GO:1990138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990138", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "regulation of synapse maturation", "id": "GO:0090128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090128", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" }, { "name": "presynaptic modulation of chemical synaptic transmission", "id": "GO:0099171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099171", "evidence": [ { "database": "UniProtKB", "id": "Q2KIC6", "url": "https://www.uniprot.org/uniprotkb/Q2KIC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIC6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIC6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIG1-1", "uniprot_ac": "Q2KIG1", "uniprot_id": "ASF1A_BOVIN", "mass": { "chemical_mass": 22938.0, "monoisotopic_mass": 22938.0 }, "refseq": { "ac": "NP_001069961", "name": "histone chaperone ASF1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961" }, "gene_names": [ { "name": "ASF1A", "type": "recommended", "evidence": [ { "id": "Q2KIG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ] }, { "name": "ASF1A", "type": "synonym", "evidence": [ { "id": "NP_001069961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961" } ] } ], "protein_names": [ { "name": "Histone chaperone ASF1A", "type": "recommended", "evidence": [ { "id": "Q2KIG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1/entry#names_and_taxonomy" } ] }, { "name": "ASF1 anti-silencing function 1 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001069961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961" } ] }, { "name": "Anti-silencing function protein 1 homolog A", "type": "synonym", "evidence": [ { "id": "Q2KIG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1/entry#names_and_taxonomy" } ] }, { "name": "anti-silencing function protein 1 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001069961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961" } ] }, { "name": "histone chaperone ASF1A", "type": "synonym", "evidence": [ { "id": "NP_001069961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961" } ] } ], "function": [ { "annotation": "Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1#function" }, { "database": "UniProtKB", "id": "Q9Y294", "url": "https://www.uniprot.org/uniprotkb/Q9Y294#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASF1A", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1", "locus": { "chromosome": "9", "start_pos": 32129040, "end_pos": 32141890, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002058", "url": "https://www.ensembl.org/id/ENSBTAG00000002058" } ] } } ], "crossref": [ { "id": "Q2KIG1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002058", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002058", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618099", "url": "https://www.ncbi.nlm.nih.gov/gene/618099", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618099", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618099", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DYADQEM", "url": "https://omabrowser.org/oma/group/DYADQEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIG1", "url": "https://www.orthodb.org/?gene=Q2KIG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12040:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12040:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559584", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069961", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLPSLLSTDALPSASKGWSTSENSLNVMLESHMDCM", "length": 204, "header": "sp|Q2KIG1-1|ASF1A_BOVIN Isoform 1 of Histone chaperone ASF1A OS=Bos taurus OX=9913 GN=ASF1A PE=2 SV=1 CANONICAL=Q2KIG1-1" }, "isoforms": [ { "isoform_ac": "Q2KIG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1/entry#Q2KIG1-1", "sequence": { "sequence": "MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLPSLLSTDALPSASKGWSTSENSLNVMLESHMDCM", "length": 204, "header": "sp|Q2KIG1-1|ASF1A_BOVIN Isoform 1 of Histone chaperone ASF1A OS=Bos taurus OX=9913 GN=ASF1A PE=2 SV=1 CANONICAL=Q2KIG1-1" }, "locus": { "chromosome": "9", "start_pos": 32141671, "end_pos": 32129227, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002664.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002664.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002664.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002664.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 192, "end_pos": 192, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by TLK2", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "site_lbl": "Ser192" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618099", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618099", "resource": "KEGG Pathway" }, { "id": "R-BTA-2559584", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559584", "resource": "Reactome", "description": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SF37-1", "protein_name": "Anti-silencing function 1A histone chaperone", "gene_name": "ASF1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDPESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM", "length": 204 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54N45-1", "protein_name": "Histone chaperone asf1", "gene_name": "asf1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHIRLTQVLIHNNPSSFNSPFIFDISFECVSPIKEDLEWKVIYVGSADNEKNDQVLDSILLGPVAVGQNQFVFEVDPPDANKIPKDDLLGVTVVFLICAYKGEDFIRVGYYVNNDYFEQELKDNPPETPDLSKIQRNVMDDKPVVTGFPIQWN", "length": 154 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6NYY4-1", "protein_name": "Histone chaperone asf1b-A", "gene_name": "asf1ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKVQVLNVAVLDNPSPFGNPFQFEITFECMEDLPEDLEWKIIYVGSAESEEYDQTLDSVLVGPVPAGRHMFVFQADAPNCSLIPETDAVGVTVVLITCTYRGQEFIRIGYYVNNEYTDTELRENPPLKPNYGQLQRNILASNPRVTRFHINWEGCAEKMEDSENVDPAPNAMLPPSCTPGKAPLLGLVPDNSMDCL", "length": 197 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CQE6-1", "protein_name": "Histone chaperone ASF1A", "gene_name": "Asf1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNAGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM", "length": 204 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LS09-1", "protein_name": "Histone chaperone ASF1B", "gene_name": "ASF1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSINITNVTVLDNPAPFVNPFQFEISYECLTSLKDDLEWKLIYVGSAEDETYDQVLESVLVGPVNVGNYRFVLQADSPDPLKIREEDIIGVTVLLLTCSYMDQEFIRVGYYVNNDYDDEQLREEPPTKVLIDKVQRNILTDKPRVTKFPINFHPENEQTLGDGPAPTEPFADSVVNGEAPVFLEQPQKLQEIEQFDDSDVNGEAIALLDQPQNLQET", "length": 218 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V464-1", "protein_name": "Histone chaperone asf1", "gene_name": "asf1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAKVHITNVVVLDNPSSFFNPFQFELTFECIEELKEDLEWKMIYVGSAESEEHDQVLDTIYVGPVPEGRHIFVFQADPPDVSKIPEPDAVGVTIVLLTCSYRGQEFVRVGYYVNNDYADPEMRENPPTKPLFEKLTRNILASKPRVTRFKINWDYGHINGNGNGVENGHQDEMATDGPSTSEAASAVIHPEDDNSLAMPMENGIKALNENSNSLAMEC", "length": 218 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y294-1", "protein_name": "Histone chaperone ASF1A", "gene_name": "ASF1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM", "length": 204 }, "evidence": [ { "id": "Q2KIG1", "url": "https://omabrowser.org/oma/group/Q2KIG1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "histone chaperone activity", "id": "GO:0140713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140713", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "DNA replication-dependent chromatin assembly", "id": "GO:0006335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006335", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIG1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIG1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIG1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG1" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Required for interaction with HIRA", "eco_id": "ECO_0000250", "start_pos": 31, "end_pos": 37, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 192 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIG4-1", "uniprot_ac": "Q2KIG4", "uniprot_id": "ALLC_BOVIN", "mass": { "chemical_mass": 46084.0, "monoisotopic_mass": 46084.0 }, "refseq": { "ac": "NP_001069377", "name": "probable inactive allantoicase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377" }, "gene_names": [ { "name": "ALLC", "type": "recommended", "evidence": [ { "id": "Q2KIG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4" } ] }, { "name": "ALLC", "type": "synonym", "evidence": [ { "id": "NP_001069377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377" } ] } ], "protein_names": [ { "name": "Probable inactive allantoicase", "type": "recommended", "evidence": [ { "id": "Q2KIG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4/entry#names_and_taxonomy" } ] }, { "name": "Allantoate amidinohydrolase", "type": "synonym", "evidence": [ { "id": "Q2KIG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4/entry#names_and_taxonomy" } ] }, { "name": "allantoate amidinohydrolase", "type": "synonym", "evidence": [ { "id": "NP_001069377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377" } ] }, { "name": "probable allantoicase", "type": "synonym", "evidence": [ { "id": "NP_001069377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377" } ] }, { "name": "probable inactive allantoicase", "type": "synonym", "evidence": [ { "id": "NP_001069377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377" } ] } ], "function": [ { "annotation": "The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG4", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4#function" }, { "database": "UniProtKB", "id": "Q8N6M5", "url": "https://www.uniprot.org/uniprotkb/Q8N6M5#function" }, { "database": "UniProtKB", "id": "G3N0Y5", "url": "https://www.uniprot.org/uniprotkb/G3N0Y5#function" }, { "database": "UniProtKB", "id": "ARBA00003893", "url": "https://www.uniprot.org/uniprotkb/ARBA00003893#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIG4", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALLC", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4", "locus": { "chromosome": "8", "start_pos": 110928191, "end_pos": 110951725, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013838", "url": "https://www.ensembl.org/id/ENSBTAG00000013838" } ] } } ], "crossref": [ { "id": "Q2KIG4", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013838", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013838", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528311", "url": "https://www.ncbi.nlm.nih.gov/gene/528311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528311", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528311", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDDGWET", "url": "https://omabrowser.org/oma/group/MDDGWET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N0Y5", "url": "https://www.orthodb.org/?gene=G3N0Y5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIG4", "url": "https://www.orthodb.org/?gene=Q2KIG4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12045:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12045:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "G3N0Y5", "url": "https://www.uniprot.org/uniprotkb/G3N0Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0Y5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIG4", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIG4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSPREGKVARPPDFTQLIDLASEFVGGKILFATDDFFAPAENLLKRDNPSFKEHEYTEFGKWMDGWQTRRKRIPGHDWCVVQLGIQGVIRGFDVDTSYFTGDHAPRVSIQAANFEEDKQPEIPQREVRTGAAATPEEFEAISELKSDDWSCLVPMTELTPGNPASSHNYFPVTSQQRWSHIRLNIFPDGGIARLRVYGTGQKDWTAGDPKEPLDLVTVAYGGACVGFSNAHFGHPNNLIGVGTATSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPESCKVDGCILTTQEEEDMVRQKWDLPGHKWKPLLPVTKLKPDEMHVLDSLTPELQDVITHAKFTITPDGGVSRLRLKGFPSSICLLRPREKPMMRFSVKAGFRANL", "length": 412, "header": "sp|Q2KIG4-1|ALLC_BOVIN Isoform 1 of Probable inactive allantoicase OS=Bos taurus OX=9913 GN=ALLC PE=2 SV=1 CANONICAL=Q2KIG4-1" }, "isoforms": [ { "isoform_ac": "G3N0Y5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4/entry#G3N0Y5-1", "sequence": { "sequence": "MADSPREGKVARPPDFTQLIDLASEFVGGKVTQALRDNPSFKEHEYTEFGKWMDGWQTRRKRIPGHDWCVVQLGIQGVIRGFDVDTSYFTGDHAPRVSIQAANFEEDKQPEIPQREVRTGAAATPEEFEAISELKSDDWSCLVPMTELTPGNPASSHNYFPVTSQQRWSHIRLNIFPDGGIARLRVYGTGQKDWTAGDPKEPLDLVTVAYGGACVGFSNAHFGHPNNLIGVGTATSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPESCKVDGCILTTQEEEDMVRQKWDLPGHKWKPLLPVTKLKPDEMHVLDSLTPELQDVITHAKFTITPDGGVSRLRLKGFPSSICLLRPREKPMMRFSVKAGFRANL", "length": 400, "header": "tr|G3N0Y5-1|G3N0Y5_BOVIN Computationally mapped isoform of Probable inactive allantoicase OS=Bos taurus OX=9913 GN=ALLC PE=3 SV=2 CANONICAL=Q2KIG4-1" }, "locus": { "chromosome": "8", "start_pos": 110948731, "end_pos": 110928326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065445.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065445.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055505.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055505.2" } ] } }, { "isoform_ac": "Q2KIG4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4/entry#Q2KIG4-1", "sequence": { "sequence": "MADSPREGKVARPPDFTQLIDLASEFVGGKILFATDDFFAPAENLLKRDNPSFKEHEYTEFGKWMDGWQTRRKRIPGHDWCVVQLGIQGVIRGFDVDTSYFTGDHAPRVSIQAANFEEDKQPEIPQREVRTGAAATPEEFEAISELKSDDWSCLVPMTELTPGNPASSHNYFPVTSQQRWSHIRLNIFPDGGIARLRVYGTGQKDWTAGDPKEPLDLVTVAYGGACVGFSNAHFGHPNNLIGVGTATSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPESCKVDGCILTTQEEEDMVRQKWDLPGHKWKPLLPVTKLKPDEMHVLDSLTPELQDVITHAKFTITPDGGVSRLRLKGFPSSICLLRPREKPMMRFSVKAGFRANL", "length": 412, "header": "sp|Q2KIG4-1|ALLC_BOVIN Isoform 1 of Probable inactive allantoicase OS=Bos taurus OX=9913 GN=ALLC PE=2 SV=1 CANONICAL=Q2KIG4-1" }, "locus": { "chromosome": "8", "start_pos": 110948731, "end_pos": 110928326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018376.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018376.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018376.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018376.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528311", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LN70-1", "protein_name": "Probable inactive allantoicase", "gene_name": "Allc", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDIPKEGKLTRFLDFTQLIDMASECVGGKVLFATDDFFAPAENLIKSNSPSFKEHEYTEFGKWMDGWETRRKRIPGHDWCVIQLGIQGIIRGVDVDISYFSGSYAPRMSIQAANLNEEKVPGIPPRGVKTGGAATPEEFGVISELKSDSWDYLVPMSELKPGDPDSSHNYFLVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWTASDSKEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGNPKSMADGWETARRLDRPPVLEENENGLLQVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPDSCKVDGCVLTTQEEEDMVRNKWTLPDHKWKPLLPVTKLFPNQTHVLDSLTLELQDVITHAKLTITPDGGISRLRLKGFPSSICLLRPLREKPMLRFTLKAGFKANL", "length": 413 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P25335-1", "protein_name": "Allantoicase", "gene_name": "DAL2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKFFSLADEAEFKSIIISKNKAVDVIGSKLGGQVVSFSDEWFASAENLIQPTAPIRDPTRFVHSGAWYDGWETRRHNEMEYDWVIIKMGVAAAHIIGGEIDTAFFNGNHAPFVSIEALYDEGEEGNIVEDDSRWVEIVEKFECGPSQRHLFVRGNGLTKERFTHIKLKMYPDGGIARFRLYGRVVPPELKTKDHIIDLAYVCNGAVALKYSDQHFGSVDNLLLPGRGHDMSDGWETKRSRQPGHTDWAVIQLGRESSFIEKIIVDTAHFRGNFPQFITVEGCLKESESSENTGEGTWVELVGKSKTGPDKEHVYEIRKSIRVSHVKLTIIPDGGVKRIRVWGY", "length": 343 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54VL5-1", "protein_name": "Allantoicase", "gene_name": "allC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVYANNNIDPNAPCYVSECAELLSDKVGGVVLGCTDQWFAECVNLIKHSAPVWDAEKYVDTGKWMDGWETKRHNPDHDWCIIKLGIPGVIYGFEIDTAYFTGNYPPHASIEALCDDSDPNFNTLKESNNWEVILNKSDLGSSCKKYFECKVEKRFTHIKFRIYPDGGVARLRAYGRVVKDWTLVIPGELVDLAAIENGGLVTQVSDHFYGNKNNIIMPGRSVNMGDGWETKRRRGPGNDWLTVKLAKEGIVKRIEVDTNWFKGNFPTSCSIDAIHSSSAPDETHLQDYEWTNILPNSPLCGHRRHFFQNELVNNDKPFTHIRLNIFPDGGVSRLRINCSLPDSKNNNNNNNNNNNNNTSNSFKTSDRQQ", "length": 369 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6AYP0-1", "protein_name": "Probable inactive allantoicase", "gene_name": "Allc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSNNPSFKENEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQGIIRGIDVDISYFSGNYAPRMSIQAANLSEDTVTNIPPRGVKMGAAATSEEFVAITELKSHSWDYLVPMSELKPGDPDSSHNYFFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGDPKSIADGWETARRLDRPPVLEGNENGFLQVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPDSCKVDGCILTTLEEEDMIRQKWSLPAHKWKPLLPVTKLTPNQNHLLDSLTLELQDVITHARITIAPDGGVSRLRLKGFPSSICLLRPLREKPMLRFSLKAGFRANL", "length": 413 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DGA6-1", "protein_name": "Allantoicase", "gene_name": "allc", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKRQVQKETRSQPHFLQFNNLACETAGGKVIFATDEWFAPARNLLKRDPPEFIASAFTEFGKWMDGWETRRKRIPGHDWCIVQLGVPGIIHGFDVDTSFFTGNYAPFASIQATCLDQMPSIALEGDRTGMAASPSQFEAVAQLNSDSWKEVVPVTKLKAGYSDTCHNYLSVSYPHRVTHIRFNIYPDGGIARLKVYGIGKKDWSSVFGQDLVDLVALVNGGVCVGFSDAHYGHPRNMIGLGMAENMGDGWETARRLDRPRVLKEDENGILQVPGSEWAIFRLGHPGIISKIELDTNHFKGNFPDSCRIEACSLTEDEENSFIQSQWSSDRSPMWNILLPPQKMKAHHRHVFSGPSLVHCGPVSHVRMVIAPDGGISRLRIWGRPVSSHQMISKL", "length": 395 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8N6M5-1", "protein_name": "Probable inactive allantoicase", "gene_name": "ALLC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDMASESVGGKILFATDDFFAPAENLIKSDSPCFKEHEYTEFGKWMDGWETRRKRIPGHDWCVLRLGIQGVIRGFDVDVSYFTGDYAPRVSIQAANLEEDKLPEIPERGTRTGAAATPEEFEAIAELKSDDWSYLVPMTELKPGNPASGHNYFLVNSQQRWTHIRLNIFPDGGIARLRVFGTGQKDWTATDPKEPADLVAIAFGGVCVGFSNAKFGHPNNIIGVGGAKSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQKWILPAHKWKPLLPVTKLSPNQSHLFDSLTLELQDVITHARLTIVPDGGVSRLRLRGFPSSICLLRPREKPMLKFSVSFKANP", "length": 391 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHX6-1", "protein_name": "Probable inactive allantoicase", "gene_name": "Allc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSDSPTFKEHEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQGIIRGIDVDISYFSGNHAPRMSIQAANLSEEDTMSNIPPRGVRMGTAATPEEFEAVTELKSHSWDYLVPMSELKLGDPDSSHNYYFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGEPKSIADGWETARRLDRPPVLEASENGLLLVPGCEWAVFRLAHPGVITQIEIDTKYFKGNCPNSCKVDGCILTTLEEEDMIRHNWNLPAHKWKSLLPVTKLIPNQNHLLDSLTLELQDVITHAMITIAPDGGVSRLRLKGFPSSICLLRPLREKPLLRFSLKTGFRANL", "length": 414 }, "evidence": [ { "id": "Q2KIG4", "url": "https://omabrowser.org/oma/group/Q2KIG4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "allantoin catabolic process", "id": "GO:0000256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000256", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG4", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "allantoicase activity", "id": "GO:0004037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004037", "evidence": [ { "database": "UniProtKB", "id": "Q2KIG4", "url": "https://www.uniprot.org/uniprotkb/Q2KIG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIG4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 412, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIG4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIG4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIH8-1", "uniprot_ac": "Q2KIH8", "uniprot_id": "CMA1C_BOVIN", "mass": { "chemical_mass": 22301.0, "monoisotopic_mass": 22301.0 }, "refseq": { "ac": "NP_001068661", "name": "ciliary microtubule associated protein 1C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" }, "gene_names": [ { "name": "CIMAP1C", "type": "recommended", "evidence": [ { "id": "Q2KIH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8" } ] }, { "name": "CIMAP1C", "type": "synonym", "evidence": [ { "id": "NP_001068661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" } ] }, { "name": "ODF3L1", "type": "synonym", "evidence": [ { "id": "NP_001068661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" }, { "id": "Q2KIH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8" } ] } ], "protein_names": [ { "name": "Ciliary microtubule associated protein 1C", "type": "recommended", "evidence": [ { "id": "Q2KIH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8/entry#names_and_taxonomy" } ] }, { "name": "Outer dense fiber protein 3-like protein 1", "type": "synonym", "evidence": [ { "id": "Q2KIH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8/entry#names_and_taxonomy" } ] }, { "name": "Protein CIMAP1C", "type": "synonym", "evidence": [ { "id": "Q2KIH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8/entry#names_and_taxonomy" } ] }, { "name": "ciliary microtubule associated protein 1C", "type": "synonym", "evidence": [ { "id": "NP_001068661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" } ] }, { "name": "outer dense fiber protein 3-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001068661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" } ] }, { "name": "protein CIMAP1C", "type": "synonym", "evidence": [ { "id": "NP_001068661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIH8", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIMAP1C", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8", "locus": { "chromosome": "21", "start_pos": 33167874, "end_pos": 33171677, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019506", "url": "https://www.ensembl.org/id/ENSBTAG00000019506" } ] } } ], "crossref": [ { "id": "Q2KIH8", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019506", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019506", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505190", "url": "https://www.ncbi.nlm.nih.gov/gene/505190", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9CPB", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9CPB&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR010736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505190", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505190", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIH8", "url": "https://www.orthodb.org/?gene=Q2KIH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21580", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21580", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21580:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21580:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009cpb", "url": "https://www.rcsb.org/structure/pdb_00009cpb", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9CPB", "url": "https://www.rcsb.org/structure/9CPB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIY7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIY7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIH8", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIH8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLPKGVKNPVFYGQQPEKKVPMSSGHEIKQTPVVLAMLKGPGPAKYLRPSCTGYIDHDVSMFQEPAYTLHAWHPEKRIMDIRSPGPCYFLDPKITRFGMASCPQVPMAEHISNLPWPPWTRTGSTRICQEAPDRPHTPGQSRPSIRTAALSIAWPNALATRWTTHLGLAPAPTMSSRSGHTSPARLLSPWASSTRPTYAR", "length": 201, "header": "sp|Q2KIH8-1|CMA1C_BOVIN Isoform 1 of Ciliary microtubule associated protein 1C OS=Bos taurus OX=9913 GN=CIMAP1C PE=2 SV=1 CANONICAL=Q2KIH8-1" }, "isoforms": [ { "isoform_ac": "A0A452DIY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8/entry#A0A452DIY7-1", "sequence": { "sequence": "MKLPKGVKNPVFYGQQPEKKVPMSSGHEIKQTPVVLAMLKGPGPAKYLRPSCTGYIDHDVSMFQEPAYTLHAWHPEKRIMDIRSPGPCYFLDPKITRFGMVSCPQVPMAEHISNLRLSPTPAPCHYHLEKTHLPGERRAPGYSFGFRCPYRVMDPNPGPNRYQMPLLLGPNLPANKAAPCYSLAPLDKNWFYKNMSRGPGPAAHTRPEPSVYQNRSPVYSMAKRFGYPVDHTPRPGPGSHNVQQVRAHKPRPPAFTMGIKHSPHLCPLIVDIRD", "length": 274, "header": "tr|A0A452DIY7-1|A0A452DIY7_BOVIN Computationally mapped isoform of Ciliary microtubule associated protein 1C OS=Bos taurus OX=9913 GN=CIMAP1C PE=1 SV=2 CANONICAL=Q2KIH8-1" }, "locus": { "chromosome": "21", "start_pos": 33171390, "end_pos": 33167877, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025983.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025983.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025983.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025983.6" } ] } }, { "isoform_ac": "Q2KIH8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8/entry#Q2KIH8-1", "sequence": { "sequence": "MKLPKGVKNPVFYGQQPEKKVPMSSGHEIKQTPVVLAMLKGPGPAKYLRPSCTGYIDHDVSMFQEPAYTLHAWHPEKRIMDIRSPGPCYFLDPKITRFGMASCPQVPMAEHISNLPWPPWTRTGSTRICQEAPDRPHTPGQSRPSIRTAALSIAWPNALATRWTTHLGLAPAPTMSSRSGHTSPARLLSPWASSTRPTYAR", "length": 201, "header": "sp|Q2KIH8-1|CMA1C_BOVIN Isoform 1 of Ciliary microtubule associated protein 1C OS=Bos taurus OX=9913 GN=CIMAP1C PE=2 SV=1 CANONICAL=Q2KIH8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 174, "start_aa": "Thr", "end_pos": 174, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr174", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIY7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIY7" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:505190", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505190", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q2KIH8", "url": "https://www.uniprot.org/uniprotkb/Q2KIH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 201, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIH8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 174 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIJ8-1", "uniprot_ac": "Q2KIJ8", "uniprot_id": "DNJ5B_BOVIN", "mass": { "chemical_mass": 22691.0, "monoisotopic_mass": 22691.0 }, "refseq": { "ac": "NP_001069334", "name": "dnaJ homolog subfamily C member 5B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" }, "gene_names": [ { "name": "DNAJC5B", "type": "recommended", "evidence": [ { "id": "Q2KIJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ] }, { "name": "DNAJC5B", "type": "synonym", "evidence": [ { "id": "NP_001069334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 5B", "type": "recommended", "evidence": [ { "id": "Q2KIJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8/entry#names_and_taxonomy" } ] }, { "name": "CSP-beta", "type": "synonym", "evidence": [ { "id": "NP_001069334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" }, { "id": "Q2KIJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8/entry#names_and_taxonomy" } ] }, { "name": "Cysteine string protein beta", "type": "synonym", "evidence": [ { "id": "Q2KIJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 5 beta", "type": "synonym", "evidence": [ { "id": "NP_001069334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" } ] }, { "name": "cysteine string protein beta", "type": "synonym", "evidence": [ { "id": "NP_001069334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" } ] }, { "name": "dnaJ homolog subfamily C member 5B", "type": "synonym", "evidence": [ { "id": "NP_001069334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC5B", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8", "locus": { "chromosome": "14", "start_pos": 30448182, "end_pos": 30355171, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015229", "url": "https://www.ensembl.org/id/ENSBTAG00000015229" } ] } } ], "crossref": [ { "id": "Q2KIJ8", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015229", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525222", "url": "https://www.ncbi.nlm.nih.gov/gene/525222", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525222", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525222", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EINKAHT", "url": "https://omabrowser.org/oma/group/EINKAHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIJ8", "url": "https://www.orthodb.org/?gene=Q2KIJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44027:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44027:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069334", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACNIPNQRQRTMSTSGKALYEILGLHKGASNEEIKKTYRKLALKHHPDKNPDDPGAAEKFKEINNAHTILTDMSKRNIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKTLFVIIGLLTGCYFCCCLCCCCNCCCGRCWTKSSMPEEDFYVSPEDLEEQIKTDIAKDMDFPVVLQPTNANEKTQLIREEPRSYCTDS", "length": 199, "header": "sp|Q2KIJ8-1|DNJ5B_BOVIN Isoform 1 of DnaJ homolog subfamily C member 5B OS=Bos taurus OX=9913 GN=DNAJC5B PE=2 SV=1 CANONICAL=Q2KIJ8-1" }, "isoforms": [ { "isoform_ac": "Q2KIJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8/entry#Q2KIJ8-1", "sequence": { "sequence": "MACNIPNQRQRTMSTSGKALYEILGLHKGASNEEIKKTYRKLALKHHPDKNPDDPGAAEKFKEINNAHTILTDMSKRNIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKTLFVIIGLLTGCYFCCCLCCCCNCCCGRCWTKSSMPEEDFYVSPEDLEEQIKTDIAKDMDFPVVLQPTNANEKTQLIREEPRSYCTDS", "length": 199, "header": "sp|Q2KIJ8-1|DNJ5B_BOVIN Isoform 1 of DnaJ homolog subfamily C member 5B OS=Bos taurus OX=9913 GN=DNAJC5B PE=2 SV=1 CANONICAL=Q2KIJ8-1" }, "locus": { "chromosome": "14", "start_pos": 30447943, "end_pos": 30393279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020262.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020262.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020262.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020262.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ], "site_lbl": "Ser14" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ], "site_lbl": "Ser16" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525222", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525222", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PFB1-1", "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "DNAJC5B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEQRQRALSTSGEALYGILALEKGATHDEIKKSYRKLALKYHPDKNPDNPEAAEKFKEINNAHATLTDLSKRNIYDKYGSLGLYVAEQFGEENVNTYFMLSSWWAKGLFAVCGLLTGCYLCCCLCCCFNCCCGKCKPKAPEGEEQEFCVSPEDLEEQIKNDMERDGETPIVLQPTNATEKTQLIGDSHRSYRTDS", "length": 196 }, "evidence": [ { "id": "Q2KIJ8", "url": "https://omabrowser.org/oma/group/Q2KIJ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZD82-1", "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "Dnajc5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACNIPNQRQRAMSTSGESLYEILGLHKGASCEEIKKTYRKLALRHHPDKNPDDPSAAEKFKEINNAHTILTDNSKRNIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKTLFIIIGLLTGCYFCCCLCCCCNCCCGHCRPKTSTPEEEFYVSPEDLEEQIRTDMEKDMDFPVVLQPTNTNEKTQLIREGSRSYCTDS", "length": 199 }, "evidence": [ { "id": "Q2KIJ8", "url": "https://omabrowser.org/oma/group/Q2KIJ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQ94-1", "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "Dnajc5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACNAPNQRQRTLSTSGESLYEILGLHKGASCEEIKKTYRKLALRHHPDKNPDDPSAAEKFKEINNAHTILTDTSKRNIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKTLFIIIGLLTGCYFCCCLCCCCNCCCGHCRPKSSTPEEEFYVSPEDLEEQIRTDMEKDMDFPVVLQPTNTNEKTQLIREGSRSYCTDS", "length": 199 }, "evidence": [ { "id": "Q2KIJ8", "url": "https://omabrowser.org/oma/group/Q2KIJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UF47-1", "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "DNAJC5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACNIPNQRQRTLSTTGEALYEILGLHKGASNEEIKKTYRKLALKHHPDKNPDDPAATEKFKEINNAHAILTDISKRSIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKALFVIVGLLTGCYFCCCLCCCCNCCCGHCRPESSVPEEDFYVSPEDLEEQIKSDMEKDVDFPVFLQPTNANEKTQLIKEGSRSYCTDS", "length": 199 }, "evidence": [ { "id": "Q2KIJ8", "url": "https://omabrowser.org/oma/group/Q2KIJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ8", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIJ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 199, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIJ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIJ8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ8" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 84, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 16 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0A3Q1LPF8-1", "uniprot_ac": "A0A3Q1LPF8", "uniprot_id": "A0A3Q1LPF8_BOVIN", "mass": { "chemical_mass": 48137.0, "monoisotopic_mass": 48137.0 }, "refseq": { "ac": "XP_005220449", "name": "growth arrest-specific protein 7 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220449" }, "gene_names": [ { "name": "GAS7", "type": "recommended", "evidence": [ { "id": "A0A3Q1LPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ] }, { "name": "GAS7", "type": "synonym", "evidence": [ { "id": "XP_005220449", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220449" } ] } ], "protein_names": [ { "name": "Growth arrest-specific protein 7", "type": "recommended", "evidence": [ { "id": "A0A3Q1LPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#names_and_taxonomy" } ] }, { "name": "growth arrest-specific protein 7 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005220449", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220449" } ] } ], "function": [ { "annotation": "May play a role in promoting maturation and morphological differentiation of cerebellar neurons.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8#function" }, { "database": "UniProtKB", "id": "ARBA00055699", "url": "https://www.uniprot.org/uniprotkb/ARBA00055699#function" }, { "database": "UniProtKB", "id": "A0A3Q1M5P1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5P1#function" }, { "database": "UniProtKB", "id": "G3MWH8", "url": "https://www.uniprot.org/uniprotkb/G3MWH8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8", "locus": { "chromosome": "19", "start_pos": 29045834, "end_pos": 29251770, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019107", "url": "https://www.ensembl.org/id/ENSBTAG00000019107" } ] } } ], "crossref": [ { "id": "A0A3Q1LPF8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LPF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019107", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019107", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07649", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07649", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11829", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11829", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614517", "url": "https://www.ncbi.nlm.nih.gov/gene/614517", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HGENSHN", "url": "https://omabrowser.org/oma/group/HGENSHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPF8", "url": "https://www.orthodb.org/?gene=A0A3Q1LPF8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5P1", "url": "https://www.orthodb.org/?gene=A0A3Q1M5P1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23065", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23065", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23065:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23065:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16623", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16623", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005220449", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220449", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPF8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5P1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5P1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5P1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD18-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWH8", "url": "https://www.uniprot.org/uniprotkb/G3MWH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWH8-1", "url": "https://www.uniprot.org/uniprotkb/G3MWH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPPMKPGMVPPPPGEESQTVVLPPGWQSYLSPQGRRYYVNTATNETTWERPSSSSGIPASPGPHRSSLPPTVNGYHTSGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDSQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYAAVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 421, "header": "tr|A0A3Q1LPF8-1|A0A3Q1LPF8_BOVIN Isoform 1 of Growth arrest-specific protein 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPF8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#A0A3Q1LPF8-1", "sequence": { "sequence": "MSSPPMKPGMVPPPPGEESQTVVLPPGWQSYLSPQGRRYYVNTATNETTWERPSSSSGIPASPGPHRSSLPPTVNGYHTSGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDSQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYAAVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 421, "header": "tr|A0A3Q1LPF8-1|A0A3Q1LPF8_BOVIN Isoform 1 of Growth arrest-specific protein 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29137106, "end_pos": 29047557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082946.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082946.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058893.1" } ] } }, { "isoform_ac": "A0A3Q1M5P1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#A0A3Q1M5P1-1", "sequence": { "sequence": "MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVVLPPGWQSYLSPQGRRYYVNTATNETTWERPSSSSGIPASPGPHRSSLPPTVNGYHTSGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDSQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYAAVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 476, "header": "tr|A0A3Q1M5P1-1|A0A3Q1M5P1_BOVIN Computationally mapped isoform of Growth arrest-specific protein 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29250914, "end_pos": 29047557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078792.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078792.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068996.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068996.1" } ] } }, { "isoform_ac": "A0A3Q1MD18-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#A0A3Q1MD18-1", "sequence": { "sequence": "MLPKWRSLEWSPLRRERKARLLSFHRAGKATCPLRAGATMSTRPPMRPPGSVPAVLLGFQPALALTGALCLQQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDSQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYAAVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 392, "header": "tr|A0A3Q1MD18-1|A0A3Q1MD18_BOVIN Computationally mapped isoform of Growth arrest specific 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29133064, "end_pos": 29047557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080292.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080292.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068791.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068791.2" } ] } }, { "isoform_ac": "A0A3Q1MIS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#A0A3Q1MIS2-1", "sequence": { "sequence": "MVPPPPGEESQTVVLPPGWQSYLSPQGRRYYVNTATNETTWERPSSSSGIPASPGPHRSSLPPTVNGYHTSGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 181, "header": "tr|A0A3Q1MIS2-1|A0A3Q1MIS2_BOVIN Computationally mapped isoform of Growth arrest specific 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29123456, "end_pos": 29047557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069070.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069070.2" } ] } }, { "isoform_ac": "A0AAA9SZD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#A0AAA9SZD7-1", "sequence": { "sequence": "MSNMENSSDDVSCLSPQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWAEPLSPVLRLPLQ", "length": 78, "header": "tr|A0AAA9SZD7-1|A0AAA9SZD7_BOVIN Computationally mapped isoform of Growth arrest specific 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29081332, "end_pos": 29047279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088732.1" } ] } }, { "isoform_ac": "G3MWH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8/entry#G3MWH8-1", "sequence": { "sequence": "MEKQGGCAKQSGSLDGSAEKPGMVPPPPGEESQTVVLPPGWQSYLSPQGRRYYVNTATNETTWERPSSSSGIPASPGPHRSSLPPTVNGYHTSGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDSQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYAAVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 434, "header": "tr|G3MWH8-1|G3MWH8_BOVIN Computationally mapped isoform of Growth arrest-specific protein 7 OS=Bos taurus OX=9913 GN=GAS7 PE=4 SV=1 CANONICAL=A0A3Q1LPF8-1" }, "locus": { "chromosome": "19", "start_pos": 29185522, "end_pos": 29047557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065891.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065891.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053878.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053878.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "O55148-1", "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATALQKPGMVPPPPGEESQTVILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPGPHRSSLPTTVNGYHASGTPAHPPETAHMSLRKSTGDSQNLGSSSPGRKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLGESRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 422 }, "evidence": [ { "id": "A0A3Q1LPF8", "url": "https://omabrowser.org/oma/group/A0A3Q1LPF8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60861-3", "protein_name": "Growth arrest-specific protein 7", "gene_name": "GAS7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 476 }, "evidence": [ { "id": "A0A3Q1LPF8", "url": "https://omabrowser.org/oma/group/A0A3Q1LPF8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60780-1", "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATALQKPGMVPPPPGEESQTVILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPAPHRSSLPTTVNGYHASGTPAHPPETAHMSLRKSTGDSQNLGSSSPGRKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 421 }, "evidence": [ { "id": "A0A3Q1LPF8", "url": "https://omabrowser.org/oma/group/A0A3Q1LPF8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "clathrin coat assembly", "id": "GO:0048268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048268", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis", "id": "GO:0072583", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072583", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" }, { "id": "PS51741", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51741" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-BAR", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 401, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF8" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 55, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0A3Q1LQT0-1", "uniprot_ac": "A0A3Q1LQT0", "uniprot_id": "A0A3Q1LQT0_BOVIN", "mass": { "chemical_mass": 94271.0, "monoisotopic_mass": 94271.0 }, "refseq": { "ac": "XP_002694563", "name": "two pore channel protein 1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694563" }, "gene_names": [ { "name": "TPCN1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ] }, { "name": "TPCN1", "type": "synonym", "evidence": [ { "id": "XP_002694563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694563" } ] } ], "protein_names": [ { "name": "Voltage-dependent calcium channel protein TPC1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#names_and_taxonomy" } ] }, { "name": "two pore channel protein 1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_002694563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694563" } ] } ], "function": [ { "annotation": "Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. Required for mTOR-dependent nutrient sensing.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M854", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M854#function" }, { "database": "UniProtKB", "id": "ARBA00058420", "url": "https://www.uniprot.org/uniprotkb/ARBA00058420#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQ38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ38#function" }, { "database": "UniProtKB", "id": "A0A3Q1NER8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NER8#function" }, { "database": "UniProtKB", "id": "F1MSJ0", "url": "https://www.uniprot.org/uniprotkb/F1MSJ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPCN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0", "locus": { "chromosome": "17", "start_pos": 61285098, "end_pos": 61225900, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011102", "url": "https://www.ensembl.org/id/ENSBTAG00000011102" } ] } } ], "crossref": [ { "id": "A0A3Q1LQT0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LQT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011102", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011102", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510830", "url": "https://www.ncbi.nlm.nih.gov/gene/510830", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510830", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510830", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQT0", "url": "https://www.orthodb.org/?gene=A0A3Q1LQT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M854", "url": "https://www.orthodb.org/?gene=A0A3Q1M854", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQ38", "url": "https://www.orthodb.org/?gene=A0A3Q1MQ38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NER8", "url": "https://www.orthodb.org/?gene=A0A3Q1NER8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSJ0", "url": "https://www.orthodb.org/?gene=F1MSJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46474", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46474", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46474:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46474:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002694563", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694563", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M854", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M854", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M854-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M854-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NER8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NER8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NER8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NER8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSJ0", "url": "https://www.uniprot.org/uniprotkb/F1MSJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MSJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVSLDDDVPLILTLDEGGSAPLAPSNGLGPDDLPSRNGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 816, "header": "tr|A0A3Q1LQT0-1|A0A3Q1LQT0_BOVIN Isoform 1 of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=2 CANONICAL=A0A3Q1LQT0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#A0A3Q1LQT0-1", "sequence": { "sequence": "MAVSLDDDVPLILTLDEGGSAPLAPSNGLGPDDLPSRNGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 816, "header": "tr|A0A3Q1LQT0-1|A0A3Q1LQT0_BOVIN Isoform 1 of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=2 CANONICAL=A0A3Q1LQT0-1" }, "locus": { "chromosome": "17", "start_pos": 61284094, "end_pos": 61228793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085172.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085172.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057367.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057367.2" } ] } }, { "isoform_ac": "A0A3Q1M854-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#A0A3Q1M854-1", "sequence": { "sequence": "MAVSLDDDVPLILTLDEGGSAPLAPSNGLGPDDLPSRTEGESSTAGPPGTSPSGPFLSCAWILHGLSSQGPPPTCLNGPSKTQIRAAASQERRKCRGEGQPSSSWRRQQRASSLTAPWRGHPVSSSWALVVCLDLAVDGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 916, "header": "tr|A0A3Q1M854-1|A0A3Q1M854_BOVIN Computationally mapped isoform of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=1 CANONICAL=A0A3Q1LQT0-1" }, "locus": { "chromosome": "17", "start_pos": 61284094, "end_pos": 61228793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073198.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073198.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064586.1" } ] } }, { "isoform_ac": "A0A3Q1MQ38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#A0A3Q1MQ38-1", "sequence": { "sequence": "MRVAAPHWLPPTAWAQMICPAEEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 758, "header": "tr|A0A3Q1MQ38-1|A0A3Q1MQ38_BOVIN Computationally mapped isoform of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=2 CANONICAL=A0A3Q1LQT0-1" }, "locus": { "chromosome": "17", "start_pos": 61284094, "end_pos": 61228839, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082890.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082890.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074080.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074080.2" } ] } }, { "isoform_ac": "A0A3Q1NER8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#A0A3Q1NER8-1", "sequence": { "sequence": "MAVSLDDDVPLILTLDEGGSAPLAPSNGLGPDDLPSRTASQERRKCRGEGQPSSSWRRQQRASSLTAPWRGHPVSSSWALVVCLDLAVDGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 867, "header": "tr|A0A3Q1NER8-1|A0A3Q1NER8_BOVIN Computationally mapped isoform of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=2 CANONICAL=A0A3Q1LQT0-1" }, "locus": { "chromosome": "17", "start_pos": 61284094, "end_pos": 61228793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068650.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068650.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070158.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070158.2" } ] } }, { "isoform_ac": "F1MSJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0/entry#F1MSJ0-1", "sequence": { "sequence": "MAVSLDDDVPLILTLDEGGSAPLAPSNGLGPDDLPSRTEGESSTAGPPGTSPSGPFLSCAWILHGLSSQGPPPTCLNGPSKTQIRADGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFTHPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALVVVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFLVDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQSNTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNLFDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLERYEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEERQLSSCVVPATQQPPGSRQRSQTIT", "length": 865, "header": "tr|F1MSJ0-1|F1MSJ0_BOVIN Computationally mapped isoform of Voltage-dependent calcium channel protein TPC1 OS=Bos taurus OX=9913 GN=TPCN1 PE=3 SV=2 CANONICAL=A0A3Q1LQT0-1" }, "locus": { "chromosome": "17", "start_pos": 61284094, "end_pos": 61228793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029530.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029530.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029529.4", "url": "https://www.ensembl.org/id/ENSBTAP00000029529.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510830", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510830", "resource": "KEGG Pathway" }, { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "ligand-gated sodium channel activity", "id": "GO:0015280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015280", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "voltage-gated sodium channel activity", "id": "GO:0005248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005248", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity", "id": "GO:0097682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097682", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "voltage-gated channel activity", "id": "GO:0022832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022832", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "NAADP-sensitive calcium-release channel activity", "id": "GO:0072345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072345", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "endolysosome", "id": "GO:0036019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036019", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis involved in viral entry into host cell", "id": "GO:0075509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 617, "end_pos": 619, "annotation": "n_glycosylation_sequon" }, { "start_pos": 696, "end_pos": 698, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] }, { "id": "34963", "name": "", "equation": "Na(+)(in) = Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "34963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34963" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT0" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 331, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 388, "end_pos": 390 }, { "start_pos": 600, "end_pos": 602 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 617, "end_pos": 619 }, { "start_pos": 696, "end_pos": 698 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0A3Q1LRA1-1", "uniprot_ac": "A0A3Q1LRA1", "uniprot_id": "A0A3Q1LRA1_BOVIN", "mass": { "chemical_mass": 23942.0, "monoisotopic_mass": 23942.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1LRA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LRA1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048777", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048777", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR021116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CYVEMKA", "url": "https://omabrowser.org/oma/group/CYVEMKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M077", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M077", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M077-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M077-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKSRGFRIPCNVGFYPTGLGMEWDACLFKILETEQTQSSGNKSSCSRWEVSEAFKCLHHFCQSAIAHRQSYCCCSFLCSQPPGAGYQRGIMGFSKLPLFLVLSMLIIHQAGMLQAAPFRSVWKNGLVPATLTEEESYFLLATMVKYYVQKASELEYETEDFGIIAQERTSNAATGMTHKMAGFLGKSGSKIKRNIMSTNVAPKPLAGTTGIFRTK", "length": 216, "header": "tr|A0A3Q1LRA1-1|A0A3Q1LRA1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LRA1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1/entry#A0A3Q1LRA1-1", "sequence": { "sequence": "MVKSRGFRIPCNVGFYPTGLGMEWDACLFKILETEQTQSSGNKSSCSRWEVSEAFKCLHHFCQSAIAHRQSYCCCSFLCSQPPGAGYQRGIMGFSKLPLFLVLSMLIIHQAGMLQAAPFRSVWKNGLVPATLTEEESYFLLATMVKYYVQKASELEYETEDFGIIAQERTSNAATGMTHKMAGFLGKSGSKIKRNIMSTNVAPKPLAGTTGIFRTK", "length": 216, "header": "tr|A0A3Q1LRA1-1|A0A3Q1LRA1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LRA1-1" }, "locus": { "chromosome": "15", "start_pos": 37884448, "end_pos": 37881261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086920.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086920.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059520.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059520.2" } ] } }, { "isoform_ac": "A0A3Q1M077-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1/entry#A0A3Q1M077-1", "sequence": { "sequence": "MEWDACLFKILETEQSAIAHRQSYCCCSFLCSQPPGAGYQRGIMGFSKLPLFLVLSMLIIHQAGMLQAAPFRSVWKNGLVPATLTEEESYFLLATMVKYYVQKASELEYETEDFGIIAQERTSNAATGMTHKMAGFLGKSGSKIKRNIMSTNVAPKPLAGTTGIFRTK", "length": 168, "header": "tr|A0A3Q1M077-1|A0A3Q1M077_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LRA1-1" }, "locus": { "chromosome": "15", "start_pos": 37884448, "end_pos": 37881324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069843.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069843.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066602.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066602.2" } ] } }, { "isoform_ac": "A0AAA9TMA4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1/entry#A0AAA9TMA4-1", "sequence": { "sequence": "MVKSRGFRIPCNVGFYPTGLGMEWDACLFKILETEQRGIMGFSKLPLFLVLSMLIIHQAGMLQAAPFRSVWKNGLVPATLTEEESYFLLATMVKYYVQKASELEYETEDFGIIAQERTSNAATGMTHKMAGFLGKSGSKIKRNIMSTNVAPKPLAGTTGIFRTK", "length": 164, "header": "tr|A0AAA9TMA4-1|A0AAA9TMA4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1LRA1-1" }, "locus": { "chromosome": "15", "start_pos": 37884448, "end_pos": 37881261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112407.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112407.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098375.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098375.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" }, { "name": "calcitonin receptor binding", "id": "GO:0031716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031716", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" }, { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0A3Q1LPP9-1", "uniprot_ac": "A0A3Q1LPP9", "uniprot_id": "A0A3Q1LPP9_BOVIN", "mass": { "chemical_mass": 122811.0, "monoisotopic_mass": 122811.0 }, "refseq": { "ac": "NP_001192801", "name": "rap guanine nucleotide exchange factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192801" }, "gene_names": [ { "name": "RAPGEF1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LPP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ] }, { "name": "RAPGEF1", "type": "synonym", "evidence": [ { "id": "NP_001192801", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192801" } ] } ], "protein_names": [ { "name": "CRK SH3-binding GNRP", "type": "recommended", "evidence": [ { "id": "A0A3Q1LPP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#names_and_taxonomy" } ] }, { "name": "Rap guanine nucleotide exchange factor (GEF) 1", "type": "synonym", "evidence": [ { "id": "NP_001192801", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192801" } ] }, { "name": "rap guanine nucleotide exchange factor 1", "type": "synonym", "evidence": [ { "id": "NP_001192801", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192801" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAPGEF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9", "locus": { "chromosome": "11", "start_pos": 101698360, "end_pos": 101834283, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020791", "url": "https://www.ensembl.org/id/ENSBTAG00000020791" } ] } } ], "crossref": [ { "id": "A0A3Q1LPP9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LPP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020791", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020791", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00155", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520454", "url": "https://www.ncbi.nlm.nih.gov/gene/520454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520454", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520454", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPP9", "url": "https://www.orthodb.org/?gene=A0A3Q1LPP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXN8", "url": "https://www.orthodb.org/?gene=A0A3Q1LXN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4X5", "url": "https://www.orthodb.org/?gene=A0A3Q1M4X5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCQ4", "url": "https://www.orthodb.org/?gene=A0A3Q1MCQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N3N1", "url": "https://www.orthodb.org/?gene=A0A3Q1N3N1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113:SF224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00617", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00617", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00618", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00618", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-170968", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-170968", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-186763", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8875555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8875555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9027284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912631", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192801", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXN8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXN8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4X5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4X5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3N1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3N1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3N1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNAVEKQKPLKRSHLCPWKQDSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1094, "header": "tr|A0A3Q1LPP9-1|A0A3Q1LPP9_BOVIN Isoform 1 of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=1 CANONICAL=A0A3Q1LPP9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#A0A3Q1LPP9-1", "sequence": { "sequence": "MGNAVEKQKPLKRSHLCPWKQDSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1094, "header": "tr|A0A3Q1LPP9-1|A0A3Q1LPP9_BOVIN Isoform 1 of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=1 CANONICAL=A0A3Q1LPP9-1" }, "locus": { "chromosome": "11", "start_pos": 101808698, "end_pos": 101699110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078029.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078029.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062071.1" } ] } }, { "isoform_ac": "A0A3Q1LXN8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#A0A3Q1LXN8-1", "sequence": { "sequence": "MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLASCAASSFSSVSYCVQQTKVAFTPEDGSAAQGISVSVSNSFLSRHGSLPVPSYKSVFRSYSQDFVPHSQASVQPFLPSTSSSSPHFPPVHQYQSSDLAVPPVASLPPSTLDGPLSSSQESSFHGNTVCLPSETSFTDSPQTPSSEHACEGDYVSLYCSGQSSEELARPRGESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1263, "header": "tr|A0A3Q1LXN8-1|A0A3Q1LXN8_BOVIN Computationally mapped isoform of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=2 CANONICAL=A0A3Q1LPP9-1" }, "locus": { "chromosome": "11", "start_pos": 101834005, "end_pos": 101699110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066818.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066818.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060297.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060297.2" } ] } }, { "isoform_ac": "A0A3Q1M4X5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#A0A3Q1M4X5-1", "sequence": { "sequence": "MKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYPCRLTLLHRAVCRVGSAMRGSAQPSSGSLRKGGGGGGGRPSLHVPTPAREDGCFFNSGSTYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1085, "header": "tr|A0A3Q1M4X5-1|A0A3Q1M4X5_BOVIN Computationally mapped isoform of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=2 CANONICAL=A0A3Q1LPP9-1" }, "locus": { "chromosome": "11", "start_pos": 101762378, "end_pos": 101699110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066386.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066386.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065294.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065294.2" } ] } }, { "isoform_ac": "A0A3Q1MCQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#A0A3Q1MCQ4-1", "sequence": { "sequence": "MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYPCRLTLLHRAVCRGSLRKGGGGGGGRPSLHVPTPAREDGCFFNSGSTYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1103, "header": "tr|A0A3Q1MCQ4-1|A0A3Q1MCQ4_BOVIN Computationally mapped isoform of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=2 CANONICAL=A0A3Q1LPP9-1" }, "locus": { "chromosome": "11", "start_pos": 101834005, "end_pos": 101699110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076502.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076502.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066577.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066577.2" } ] } }, { "isoform_ac": "A0A3Q1N3N1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9/entry#A0A3Q1N3N1-1", "sequence": { "sequence": "MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQSDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGHPSPTSPVKPSSPACKPDSQSELPLTDREMEILNKTTSLSQSTEGLQDSMDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYSGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVACNLSPLPESLGESGSPFLGHPLQLPLGSCPQPDGSSAPGQQTDVPPALPEKKRRSAASQTLDSSGCRASYERHPSQYDNISEDDLQNPASVQSVPFTPFAAILPFQQGGSSASVDFMGDFTVSESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQKEHVYQQKNKLLMEVYGFNDSFSTGDAAHDLAPPPALPPKQRQLESPAAKDGHSRDATSASCVPGKEGRDSGDRARKSPDAPEAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIQKLQYRYPCRLTLLHRAVCRGSLRKGGGGGGGRPSLHVPTPAREDGCFFNSGSTYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVRSGELSLARVLRKNILDKVDQKKLLRCANSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1141, "header": "tr|A0A3Q1N3N1-1|A0A3Q1N3N1_BOVIN Computationally mapped isoform of CRK SH3-binding GNRP OS=Bos taurus OX=9913 GN=RAPGEF1 PE=4 SV=2 CANONICAL=A0A3Q1LPP9-1" }, "locus": { "chromosome": "11", "start_pos": 101834005, "end_pos": 101699110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086284.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086284.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064183.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064183.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520454", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520454", "resource": "KEGG Pathway" }, { "id": "R-BTA-170968", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-170968", "resource": "Reactome", "description": "Frs2-mediated activation" }, { "id": "R-BTA-186763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "resource": "Reactome", "description": "Downstream signal transduction" }, { "id": "R-BTA-8875555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8875555", "resource": "Reactome", "description": "MET activates RAP1 and RAC1" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-9027284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027284", "resource": "Reactome", "description": "Erythropoietin activates RAS" }, { "id": "R-BTA-912631", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912631", "resource": "Reactome", "description": "Regulation of signaling by CBL" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "Rap protein signal transduction", "id": "GO:0032486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032486", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1025, "end_pos": 1027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1082, "end_pos": 1084, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 895, "end_pos": 897, "annotation": "n_glycosylation_sequon" }, { "start_pos": 905, "end_pos": 907, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LPP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" }, { "id": "PS50212", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50212" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-terminal Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 705, "end_pos": 827, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1LPP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPP9" }, { "id": "PS50009", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50009" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 857, "end_pos": 1081, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1025, "end_pos": 1027 }, { "start_pos": 107, "end_pos": 109 }, { "start_pos": 1082, "end_pos": 1084 }, { "start_pos": 263, "end_pos": 265 }, { "start_pos": 395, "end_pos": 397 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 505, "end_pos": 507 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 895, "end_pos": 897 }, { "start_pos": 905, "end_pos": 907 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LK9-1", "uniprot_ac": "Q32LK9", "uniprot_id": "SYCE1_BOVIN", "mass": { "chemical_mass": 36776.0, "monoisotopic_mass": 36776.0 }, "refseq": { "ac": "NP_001033238", "name": "synaptonemal complex central element protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033238" }, "gene_names": [ { "name": "SYCE1", "type": "recommended", "evidence": [ { "id": "Q32LK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ] }, { "name": "SYCE1", "type": "synonym", "evidence": [ { "id": "NP_001033238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033238" } ] } ], "protein_names": [ { "name": "Synaptonemal complex central element protein 1", "type": "recommended", "evidence": [ { "id": "Q32LK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LK9/entry#names_and_taxonomy" } ] }, { "name": "synaptonemal complex central element protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033238" } ] } ], "function": [ { "annotation": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9#function" }, { "database": "UniProtKB", "id": "Q9D495", "url": "https://www.uniprot.org/uniprotkb/Q9D495#function" }, { "database": "UniProtKB", "id": "A0A452DJF4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF4#function" }, { "database": "UniProtKB", "id": "ARBA00045754", "url": "https://www.uniprot.org/uniprotkb/ARBA00045754#function" }, { "database": "UniProtKB", "id": "A0A3Q1MX88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYCE1", "url": "https://www.uniprot.org/uniprotkb/Q32LK9", "locus": { "chromosome": "26", "start_pos": 50141643, "end_pos": 50136560, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035072", "url": "https://www.ensembl.org/id/ENSBTAG00000035072" } ] } } ], "crossref": [ { "id": "Q32LK9", "url": "https://alphafold.ebi.ac.uk/entry/Q32LK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035072", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035072", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529478", "url": "https://www.ncbi.nlm.nih.gov/gene/529478", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529478", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529478", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LK9", "url": "https://www.orthodb.org/?gene=Q32LK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21731", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21731", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21731:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21731:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15233", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15233", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033238", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LK9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRPGSSNAEAAGAVGPTDEARGQAESSQKIEDLMEMVKKLQKVGSLEPRVEVLINRINEVQQAKKKASEELGDARTVWETLQKELDSLSGEKVRLKEILSKKQETLRVLRLHCQDKENEAQRKQTMLQECKERISALNSQIEQEKNKQRQLRLDFEEQLEDLMGQYKDLWEFHKPERLALEISTLDSGKEQLLKEEKLVEAKLEDVKHRLCSQFGAKGHTINEGLFLRSPEAAAVVHLFEEENRKAQELLEAAAQRQEQLQQKCQQLQQKRQRLKEELEKLGVQVLAQAQSKQEEEAGLGEAANPKPLGVSEEKDQEPSTK", "length": 323, "header": "sp|Q32LK9-1|SYCE1_BOVIN Isoform 1 of Synaptonemal complex central element protein 1 OS=Bos taurus OX=9913 GN=SYCE1 PE=2 SV=2 CANONICAL=Q32LK9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MX88-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK9/entry#A0A3Q1MX88-1", "sequence": { "sequence": "PQGRPRHPPSSACPVIFTQPPFLPAVGSLEPRVEVLINRINEVQQAKKKASEELGDARTVWETLQKELDSLSGEKVRLKEILSKKQETLRVLRLHCQDKENEAQRKQTMLQECKERISALNSQIEQEKNKQRQLRLDFEEQLEDLMGQYKDLWEFHKPERLALEISTLDSGKEQLLKEEKLVEAKLEDVKHRLCSQFGAKGHTINEGLFLRSPEAAAVVHLFEEENRKAQELLEAAAQRQEQLQQKCQQLQQKRQRWLRELKEELEKLGVQVLAQAQSKQEEEAGLGEAANPKPLGVSEEKDQEPSTK", "length": 308, "header": "tr|A0A3Q1MX88-1|SYCE1_BOVIN Computationally mapped isoform of Synaptonemal complex central element protein 1 OS=Bos taurus OX=9913 GN=SYCE1 PE=2 SV=2 CANONICAL=Q32LK9-1" }, "locus": { "chromosome": "26", "start_pos": 50141554, "end_pos": 50136662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060304.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060304.2" } ] } }, { "isoform_ac": "A0A452DJF4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK9/entry#A0A452DJF4-1", "sequence": { "sequence": "MFGFVSTGQAESSQKIEDLMEMVKKLQKVGSLEPRVEVLINRINEVQQAKKKASEELGDARTVWETLQKELDSLSGEKVRLKEILSKKQETLRVLRLHCQDKENEAQRKQTMLQECKERISALNSQIEQEKNKQRQLRLDFEEQLEDLMGQYKDLWEFHKPERLALEISTLDSGKEQLLKEEKLVEAKLEDVKHRLCSQFGAKGHTINEGLFLRSPEAAAVVHLFEEENRKAQELLEAAAQRQEQLQQKCQQLQQKRQRLKEELEKLGVQVLAQAQSKQEEEAGLGEAANPKPLGVSEEKDQEPSTK", "length": 307, "header": "tr|A0A452DJF4-1|SYCE1_BOVIN Computationally mapped isoform of Synaptonemal complex central element protein 1 OS=Bos taurus OX=9913 GN=SYCE1 PE=2 SV=2 CANONICAL=Q32LK9-1" }, "locus": { "chromosome": "26", "start_pos": 50141554, "end_pos": 50136646, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049542.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049542.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046422.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046422.4" } ] } }, { "isoform_ac": "Q32LK9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK9/entry#Q32LK9-1", "sequence": { "sequence": "MAGRPGSSNAEAAGAVGPTDEARGQAESSQKIEDLMEMVKKLQKVGSLEPRVEVLINRINEVQQAKKKASEELGDARTVWETLQKELDSLSGEKVRLKEILSKKQETLRVLRLHCQDKENEAQRKQTMLQECKERISALNSQIEQEKNKQRQLRLDFEEQLEDLMGQYKDLWEFHKPERLALEISTLDSGKEQLLKEEKLVEAKLEDVKHRLCSQFGAKGHTINEGLFLRSPEAAAVVHLFEEENRKAQELLEAAAQRQEQLQQKCQQLQQKRQRLKEELEKLGVQVLAQAQSKQEEEAGLGEAANPKPLGVSEEKDQEPSTK", "length": 323, "header": "sp|Q32LK9-1|SYCE1_BOVIN Isoform 1 of Synaptonemal complex central element protein 1 OS=Bos taurus OX=9913 GN=SYCE1 PE=2 SV=2 CANONICAL=Q32LK9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 19, "start_aa": "Thr", "end_pos": 19, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr19", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529478", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529478", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ], "pmid": "" }, { "name": "synaptonemal complex assembly", "id": "GO:0007130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ], "pmid": "" }, { "name": "synaptonemal complex", "id": "GO:0000795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000795", "evidence": [ { "database": "UniProtKB", "id": "Q32LK9", "url": "https://www.uniprot.org/uniprotkb/Q32LK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LK9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LK9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LK9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 19 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58D20-1", "uniprot_ac": "Q58D20", "uniprot_id": "NLE1_BOVIN", "mass": { "chemical_mass": 53229.0, "monoisotopic_mass": 53229.0 }, "refseq": { "ac": "NP_001014887", "name": "notchless protein homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014887" }, "gene_names": [ { "name": "NLE1", "type": "recommended", "evidence": [ { "id": "Q58D20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ] }, { "name": "NLE1", "type": "synonym", "evidence": [ { "id": "NP_001014887", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014887" } ] } ], "protein_names": [ { "name": "Notchless protein homolog 1", "type": "recommended", "evidence": [ { "id": "Q58D20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D20/entry#names_and_taxonomy" } ] }, { "name": "Notchless gene homolog", "type": "synonym", "evidence": [ { "id": "NP_001014887", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014887" } ] }, { "name": "notchless protein homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001014887", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014887" } ] } ], "function": [ { "annotation": "Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20#function" }, { "database": "UniProtKB", "id": "A0A3Q1N213", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N213#function" }, { "database": "UniProtKB", "id": "ARBA00054506", "url": "https://www.uniprot.org/uniprotkb/ARBA00054506#function" }, { "database": "UniProtKB", "id": "A0A3Q1LXH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NLE1", "url": "https://www.uniprot.org/uniprotkb/Q58D20", "locus": { "chromosome": "19", "start_pos": 14963357, "end_pos": 14954527, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019094", "url": "https://www.ensembl.org/id/ENSBTAG00000019094" } ] } } ], "crossref": [ { "id": "Q58D20", "url": "https://alphafold.ebi.ac.uk/entry/Q58D20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019094", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019094", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509793", "url": "https://www.ncbi.nlm.nih.gov/gene/509793", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509793", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509793", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWEPYHR", "url": "https://omabrowser.org/oma/group/AWEPYHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXH3", "url": "https://www.orthodb.org/?gene=A0A3Q1LXH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M626", "url": "https://www.orthodb.org/?gene=A0A3Q1M626", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N213", "url": "https://www.orthodb.org/?gene=A0A3Q1N213", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58D20", "url": "https://www.orthodb.org/?gene=Q58D20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19848:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19848:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014887", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M626", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M626", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M626-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M626-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N213", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N213", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N213-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N213-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D20-1", "url": "https://www.uniprot.org/uniprotkb/Q58D20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAAADEAATRDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEDPLPLAFYVHDAEIVSSLGRTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRALTGHSKWITALSWEPLHANPECRYVASSSKDGSVRVWDTTAGRCERTLTGHAQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNAQDLRGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVVFSPDSRVIASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLSTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 486, "header": "sp|Q58D20-1|NLE1_BOVIN Isoform 1 of Notchless protein homolog 1 OS=Bos taurus OX=9913 GN=NLE1 PE=2 SV=3 CANONICAL=Q58D20-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXH3-1", "url": "https://www.uniprot.org/uniprotkb/Q58D20/entry#A0A3Q1LXH3-1", "sequence": { "sequence": "MAAAAAADEAATRDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEDPLPLAFYVHDAEIVSSLGRTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRALTGHSKWITALSWEPLHANPECRYVASSSKDGSVRVWDTTAGRCERTLTGHAQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNAQDLRGSGLLPETMCASLPPQGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVVFSPDSRVIASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLSTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 484, "header": "tr|A0A3Q1LXH3-1|A0A3Q1LXH3_BOVIN Computationally mapped isoform of Notchless protein homolog 1 OS=Bos taurus OX=9913 GN=NLE1 PE=4 SV=1 CANONICAL=Q58D20-1" }, "locus": { "chromosome": "19", "start_pos": 14963026, "end_pos": 14954581, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072193.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072193.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062201.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062201.1" } ] } }, { "isoform_ac": "A0A3Q1M626-1", "url": "https://www.uniprot.org/uniprotkb/Q58D20/entry#A0A3Q1M626-1", "sequence": { "sequence": "MAAAAADEAATRDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEDPLPLAFYVHDAEIVSSLGRTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTILLWDPSTGKQVGRALTGHSKWITALSWEPLHANPECRYVASSSKDGSVRVWDTTAGRCERTLTGHAQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNAQDLRGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVVFSPDSRVIASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLSTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 443, "header": "tr|A0A3Q1M626-1|A0A3Q1M626_BOVIN Computationally mapped isoform of Notchless protein homolog 1 OS=Bos taurus OX=9913 GN=NLE1 PE=4 SV=2 CANONICAL=Q58D20-1" }, "locus": { "chromosome": "19", "start_pos": 14963026, "end_pos": 14954581, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080209.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080209.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063737.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063737.2" } ] } }, { "isoform_ac": "A0A3Q1N213-1", "url": "https://www.uniprot.org/uniprotkb/Q58D20/entry#A0A3Q1N213-1", "sequence": { "sequence": "RPPRLSAQDEAATRDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEDPLPLAFYVHDAEIVSSLGRTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRALTGHSKWITALSWEPLHANPECRYVASSSKDGSVRVWDTTAGRCERTLTGHAQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNAQDLRGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVVFSPDSRVIASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLSTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 487, "header": "tr|A0A3Q1N213-1|NLE1_BOVIN Computationally mapped isoform of Notchless protein homolog 1 OS=Bos taurus OX=9913 GN=NLE1 PE=2 SV=1 CANONICAL=Q58D20-1" }, "locus": { "chromosome": "19", "start_pos": 14963026, "end_pos": 14954714, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067467.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067467.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063224.1" } ] } }, { "isoform_ac": "Q58D20-1", "url": "https://www.uniprot.org/uniprotkb/Q58D20/entry#Q58D20-1", "sequence": { "sequence": "MAAAAAADEAATRDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEDPLPLAFYVHDAEIVSSLGRTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRALTGHSKWITALSWEPLHANPECRYVASSSKDGSVRVWDTTAGRCERTLTGHAQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNAQDLRGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVVFSPDSRVIASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLSTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 486, "header": "sp|Q58D20-1|NLE1_BOVIN Isoform 1 of Notchless protein homolog 1 OS=Bos taurus OX=9913 GN=NLE1 PE=2 SV=3 CANONICAL=Q58D20-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 105, "start_aa": "Thr", "end_pos": 105, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr105", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "site_lbl": "Ser80" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509793", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509793", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "C7FZX3-1", "protein_name": "WD40 repeat-containing protein", "gene_name": "nle1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNERPKTKQMPKQKFGFSKPEYIPTTVGEAIKLESQEPSLNLIVQFKNKDSENDTTGPPINISQNVTTEQLQMLINSLLNNDEQLPYSFFVNDQEITNNLKNHLEGLSDETTLSIYYQPQAVFRVRPVTRCASSMSGHTEAVLNCAFSPDGKGFVSVGGDTTVRIWDIYTSTPTHTLKGHTNWVLQVAWSPDSKKIATAGMEGDIRIWCPQTGKQLGSTLKGHTKFITGLSWEPFHLNPKCVRLASSSKDSTIRIWDTESCKNLMSLSGHTMSVTCLKWGGEGLIYSGSQDRTVRVFNTTDGRLVRVLDGHAHWVNTLALNTDYVLRTGSYDHTGKEYDTLEEAQRVALERYNDVKAKSKGMEILISGSDDFTVIMWNPSVTKTSISRLTGHQQLINLVSFSPDGRYFASASFDKSIKLWDGQSGKFLGNFRGHVGAVYQVCWSSDSRYLVSGSKDSTLKIWDIKTKKMEKELPGHADEVYTVDWSPDGDRVASGSKDRLLRIWTV", "length": 507 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "F1QDT3-1", "protein_name": "Notchless protein homolog 1", "gene_name": "nle1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSADVERVLIQLQDEAGEVLGSPFDVPLDISPDKLQLVCNALLQKEEPVPFLFFVKDAELVSSLGSCIQTLGLETEQVLPVVYQPQAVFRVRAVARCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWDPVTGKQIGKTLTGHTKWITWLCWEPLHLNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDGLLYTSSQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDYVLRTGAFEPANATINPQDLTGSLEEIKEKALKRYNSVRGEGHERLVSGSDDFTMFLWNPAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWRK", "length": 476 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F7FIP9-1", "protein_name": "Notchless protein homolog 1", "gene_name": "Nle1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAVEDEAAASDVQRLLVQFQDEGGQLLGSPFDVPVDITPDQLQLVCNALLAQDEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 485 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P25382-1", "protein_name": "Ribosome assembly protein 4", "gene_name": "RSA4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTLIPPPSKKQKKEAQLPREVAIIPKDLPNVSIKFQALDTGDNVGGALRVPGAISEKQLEELLNQLNGTSDDPVPYTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWTH", "length": 515 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8VEJ4-1", "protein_name": "Notchless protein homolog 1", "gene_name": "Nle1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVVEEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 485 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FLX9-1", "protein_name": "Notchless protein homolog", "gene_name": "NLE1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTMMDTDEGKTVMCLLTDPEGTHLGSAMYIPQKAGPLQLTQLVNRFLDNEEMLPYSFYVSDEELLVPVGTYLEKNKVSVEKVLTIVYQQQAVFRIRPVNRCSQTIAGHAEAVLCVSFSPDGKQLASGSGDTTVRLWDLYTETPLFTCKGHKNWVLTVAWSPDGKHLVSGSKSGEICCWNPKKGELEGSPLTGHKKWITGISWEPVHLSSPCRRFVTSSKDGDARIWDITLKKSIICLSGHTLAVTCVKWGGDGIIYTGSQDCTIKMWETTQGKLIRELKGHGHWINSLALSTEYVLRTGAFDHTGRQYPPNEEKQKALERYNKTKGDSPERLVSGSDDFTMFLWEPSVSKQPKKRLTGHQQLVNHVYFSPDGKWIASASFDKSVRLWNGITGQFVTVFRGHVGPVYQVSWSADSRLLLSGSKDSTLKIWEIRTKKLKQDLPGHADEVFAVDWSPDGEKVVSGGKDRVLKLWKG", "length": 473 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NVX2-1", "protein_name": "Notchless protein homolog 1", "gene_name": "NLE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR", "length": 485 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPR4-1", "protein_name": "Protein Notchless", "gene_name": "Nle", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLAKKQKMQETDTEQEATPHTIQARLVSDTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKKSLEDTLDLASVDTENVIDIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYHRDPECRKLASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDRTVKMWRAADGILCRTFSGHAHWVNNIALSTDYVLRTGPFHPVKDRSKSHLSLSTEELQESALKRYQAVCPDEVESLVSCSDDNTLYLWRNNQNKCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRGHVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGGKDKVIKLWAY", "length": 488 }, "evidence": [ { "id": "Q58D20", "url": "https://omabrowser.org/oma/group/Q58D20/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "pmid": "" }, { "name": "regulation of Notch signaling pathway", "id": "GO:0008593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008593", "evidence": [ { "database": "UniProtKB", "id": "Q58D20", "url": "https://www.uniprot.org/uniprotkb/Q58D20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D20-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 486, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D20-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D20" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 105 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 80 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CY2-1", "uniprot_ac": "Q58CY2", "uniprot_id": "EIF1A_BOVIN", "mass": { "chemical_mass": 19143.0, "monoisotopic_mass": 19143.0 }, "refseq": { "ac": "NP_001069861", "name": "probable RNA-binding protein EIF1AD", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069861" }, "gene_names": [ { "name": "EIF1AD", "type": "recommended", "evidence": [ { "id": "Q58CY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ] }, { "name": "EIF1AD", "type": "synonym", "evidence": [ { "id": "NP_001069861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069861" } ] } ], "protein_names": [ { "name": "Probable RNA-binding protein EIF1AD", "type": "recommended", "evidence": [ { "id": "Q58CY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY2/entry#names_and_taxonomy" } ] }, { "name": "Eukaryotic translation initiation factor 1A domain-containing protein", "type": "synonym", "evidence": [ { "id": "Q58CY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY2/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 1A domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001069861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069861" } ] }, { "name": "probable RNA-binding protein EIF1AD", "type": "synonym", "evidence": [ { "id": "NP_001069861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069861" } ] } ], "function": [ { "annotation": "Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2#function" } ] }, { "annotation": "Plays a role into cellular response to oxidative stress. Decreases cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NCM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCM6#function" }, { "database": "UniProtKB", "id": "ARBA00025398", "url": "https://www.uniprot.org/uniprotkb/ARBA00025398#function" }, { "database": "UniProtKB", "id": "A0AAF6Z7A4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7A4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF1AD", "url": "https://www.uniprot.org/uniprotkb/Q58CY2", "locus": { "chromosome": "29", "start_pos": 44090209, "end_pos": 44093376, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020186", "url": "https://www.ensembl.org/id/ENSBTAG00000020186" } ] } } ], "crossref": [ { "id": "Q58CY2", "url": "https://alphafold.ebi.ac.uk/entry/Q58CY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020186", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020186", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05792", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05792", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615726", "url": "https://www.ncbi.nlm.nih.gov/gene/615726", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615726", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615726", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FRKNIWV", "url": "https://omabrowser.org/oma/group/FRKNIWV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NCM6", "url": "https://www.orthodb.org/?gene=A0A3Q1NCM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CY2", "url": "https://www.orthodb.org/?gene=Q58CY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21641", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21641", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21641:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21641:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069861", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7A4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7A4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CY2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQATKRKHVVKEVLGEHMVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKDGHWPEAFSQVTEKDNNDRNRQTQPELPAEPQSSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA", "length": 166, "header": "sp|Q58CY2-1|EIF1A_BOVIN Isoform 1 of Probable RNA-binding protein EIF1AD OS=Bos taurus OX=9913 GN=EIF1AD PE=2 SV=1 CANONICAL=Q58CY2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NCM6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY2/entry#A0A3Q1NCM6-1", "sequence": { "sequence": "MSQATKRKHVVKEVLGEHMVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHGGPLGHWLPHFPGGFAFSQVTEKDNNDRNRQTQPELPAEPQSSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA", "length": 169, "header": "tr|A0A3Q1NCM6-1|EIF1A_BOVIN Computationally mapped isoform of Probable RNA-binding protein EIF1AD OS=Bos taurus OX=9913 GN=EIF1AD PE=2 SV=1 CANONICAL=Q58CY2-1" }, "locus": { "chromosome": "29", "start_pos": 44091916, "end_pos": 44090471, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086557.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086557.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069164.1" } ] } }, { "isoform_ac": "A0AAF6Z7A4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY2/entry#A0AAF6Z7A4-1", "sequence": { "sequence": "MSQATKRKHVVKEVLGEHMVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKDGHWPEAFSQVTEKDNNDRNRLSQNSQLSHSRQEKSPALKTILTFLLTPTADSIMRARRRVKRKRRPETAGPASPLAQRLVLGSSERGHSQGALRIFPPGWGQGRAPL", "length": 206, "header": "tr|A0AAF6Z7A4-1|A0AAF6Z7A4_BOVIN Computationally mapped isoform of Probable RNA-binding protein EIF1AD OS=Bos taurus OX=9913 GN=EIF1AD PE=3 SV=1 CANONICAL=Q58CY2-1" }, "locus": { "chromosome": "29", "start_pos": 44091916, "end_pos": 44090347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026889.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026889.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026889.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026889.6" } ] } }, { "isoform_ac": "Q58CY2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY2/entry#Q58CY2-1", "sequence": { "sequence": "MSQATKRKHVVKEVLGEHMVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKDGHWPEAFSQVTEKDNNDRNRQTQPELPAEPQSSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA", "length": 166, "header": "sp|Q58CY2-1|EIF1A_BOVIN Isoform 1 of Probable RNA-binding protein EIF1AD OS=Bos taurus OX=9913 GN=EIF1AD PE=2 SV=1 CANONICAL=Q58CY2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser132" }, { "start_pos": 136, "end_pos": 136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser136" }, { "start_pos": 137, "end_pos": 137, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser137" }, { "start_pos": 138, "end_pos": 138, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser138" }, { "start_pos": 156, "end_pos": 156, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser156" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Ser160" }, { "start_pos": 33, "end_pos": 33, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "site_lbl": "Thr33" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615726", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615726", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RU32-1", "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "EIF1AD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQATKRKHVVKEVLGEHMVPSDRQQIVRVLRTPGNNLHEVETAQGQHFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCRNHVRALQKEGLWPQAFSEVAEKHDDNSNRQTQPELPAEPRLSEDKSSSEDDSDLFVNTNRRQYHESEEESEEEEAA", "length": 166 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4II37-1", "protein_name": "Nucleic acid-binding, OB-fold-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNRGRRNLKQAASDQDFTLEECQSIAQVVSLRGSNQIEIMDAKGENSLALFPAKFRESMWIRRGSFVVIDHTGKEKAQESGSKVTSIVCKVLFFEQVRLLQKSPEWPEIFKDTRPIPAEKSSPIEQHEDDGEVDSSDDDDGMPPLQANTNRLRPFGVKCDAETDSGSDSDS", "length": 171 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3I2F6-1", "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Eif1ad", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQATKRKHVVQEVLGEHMVPSDQQQIVKVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKNHVRSLQKEGHWPEAFSEVAEKQNSMNRQSQPELPAEPQLSGDESGSEDDSDLFVNTNHRQYHESEEESEEEEEDEDEEAA", "length": 171 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3THJ3-1", "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Eif1ad", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQASKRKHVVQEVLGEHMVPSDHQQIVKVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKNHVRSLQKEGHWPEAFSEVAEKQNNMNRESQPELPAEPQLSGEGSSSEDDSDLFVNTNHRQYHESEEESEEDEEEEEEAA", "length": 170 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54DL9-1", "protein_name": "S1-like domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHARKHVTNQSLNSSLKLENDQNIVKVIDMRGGNVVEVQYPNGSTVLAIIPSKFKNILWIKKGNYAIIDKEDESSKSSQVKCSVVHILSKENVKGLVKSRDWPKEFDLEDKNQRQQPQKPLLLTAPTSDDEDGGLSDLGVNPNRKKFGRVDSDEEDLSDEEEEEEEEEEEEEEEEEEEEEDN", "length": 183 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5RKI6-1", "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Eif1ad", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQASKRKHVVQEVLGEHMVPSDQQQIVKVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKNHVRSLQKEGHWPEAFSEVAEKQNNVNRESQPELPAEPQLSGEGSGSEDDSDLFVNTNHRQYHESEEESEEEEEEAA", "length": 167 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N9N8-1", "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "EIF1AD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQATKRKHVVKEVLGEHIVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKEGFWPEAFSEVAEKHNNRNRQTQPELPAEPQLSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA", "length": 165 }, "evidence": [ { "id": "Q58CY2", "url": "https://omabrowser.org/oma/group/Q58CY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58CY2", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CY2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 6, "end_pos": 12, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY2" }, { "id": "PRU00181", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "S1-like", "eco_id": "ECO_0000255", "start_pos": 5, "end_pos": 89, "start_aa": "Thr", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 33, 132, 136, 137, 138, 156, 160 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZD4-1", "uniprot_ac": "Q3SZD4", "uniprot_id": "WDR18_BOVIN", "mass": { "chemical_mass": 47611.0, "monoisotopic_mass": 47611.0 }, "refseq": { "ac": "NP_001029760", "name": "WD repeat-containing protein 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029760" }, "gene_names": [ { "name": "WDR18", "type": "recommended", "evidence": [ { "id": "Q3SZD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ] }, { "name": "WDR18", "type": "synonym", "evidence": [ { "id": "NP_001029760", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029760" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 18", "type": "recommended", "evidence": [ { "id": "Q3SZD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 18", "type": "synonym", "evidence": [ { "id": "NP_001029760", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029760" } ] } ], "function": [ { "annotation": "Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4#function" }, { "database": "UniProtKB", "id": "Q9BV38", "url": "https://www.uniprot.org/uniprotkb/Q9BV38#function" }, { "database": "UniProtKB", "id": "Q68EI0", "url": "https://www.uniprot.org/uniprotkb/Q68EI0#function" }, { "database": "UniProtKB", "id": "A0AAA9TCA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA8#function" }, { "database": "UniProtKB", "id": "RU369067", "url": "https://www.uniprot.org/uniprotkb/RU369067#function" }, { "database": "UniProtKB", "id": "ARBA00045929", "url": "https://www.uniprot.org/uniprotkb/ARBA00045929#function" }, { "database": "UniProtKB", "id": "A0A452DHW5", "url": "https://www.uniprot.org/uniprotkb/A0A452DHW5#function" }, { "database": "UniProtKB", "id": "A0AAA9SS44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS44#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR18", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4", "locus": { "chromosome": "7", "start_pos": 43513318, "end_pos": 43504876, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002434", "url": "https://www.ensembl.org/id/ENSBTAG00000002434" } ] } } ], "crossref": [ { "id": "Q3SZD4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002434", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002434", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533356", "url": "https://www.ncbi.nlm.nih.gov/gene/533356", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533356", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533356", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GVNARIY", "url": "https://omabrowser.org/oma/group/GVNARIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHW5", "url": "https://www.orthodb.org/?gene=A0A452DHW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZD4", "url": "https://www.orthodb.org/?gene=Q3SZD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18763:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18763:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14077", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14077", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029760", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DHW5", "url": "https://www.uniprot.org/uniprotkb/A0A452DHW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHW5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZD4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYICAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGISENIYLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLAWSLCSVLQADPSRTPAPRHVWSRHTLPITDLHCGFGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGILAVTMDLAEHYMFCGGSDGSIFQVDLCTWPGQREKSFQPEQEHGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSQQCLRTVTLKGPVTNACIMLAPVSMLSSDFRPGLPLPHFNKHLLGAEHGDEPHRGGLMLRLGLHQQGSEPSYLERVEQLQAVMSSTLEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHPTK", "length": 432, "header": "sp|Q3SZD4-1|WDR18_BOVIN Isoform 1 of WD repeat-containing protein 18 OS=Bos taurus OX=9913 GN=WDR18 PE=2 SV=1 CANONICAL=Q3SZD4-1" }, "isoforms": [ { "isoform_ac": "A0A452DHW5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4/entry#A0A452DHW5-1", "sequence": { "sequence": "MITHVRGGGEGKMAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYICAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGISENIYLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLAWSLCSVLQADPSRTPAPRHVWSRHTLPITDLHCGFGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGILAVTMDLAEHYMFCGGSDGSIFQVDLCTWPGQREKSFQPEQEHGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSQQCLRTVTLKGPVTNACIMLAPVSMLSSDFRPGLPLPHFNKHLLGAEHGDEPHRGGLMLRLGLHQQGSEPSYLERVEQLQAVMSSTLEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHPTK", "length": 444, "header": "tr|A0A452DHW5-1|WDR18_BOVIN Computationally mapped isoform of WD repeat-containing protein 18 OS=Bos taurus OX=9913 GN=WDR18 PE=2 SV=1 CANONICAL=Q3SZD4-1" }, "locus": { "chromosome": "7", "start_pos": 43510098, "end_pos": 43504849, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003156.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003156.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003156.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003156.6" } ] } }, { "isoform_ac": "A0AAA9SS44-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4/entry#A0AAA9SS44-1", "sequence": { "sequence": "MAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYICAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGISENIYLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLAWSLCSVLQADPSRTPAPRHVWSRHTLPITDLHCGFGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGILAVTMDLAEHYMFCGGSDGSIFQVDLCTWPGQREKSFQPEQEHGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSQQCLRTVTLKGPVTNACIMLAPVSMLSSDFRPGLPLPHFNKHLLGAEHGDEPHRGGLMLRLGLHQQGSEPSYLERVEQLQAVMSSTLEKNVLGGQDQLRIRVTELEDEQSLYRYLAHRNESRRPEEMFTHPCSHQCDSQQPKSGDNQIVKDDG", "length": 453, "header": "tr|A0AAA9SS44-1|A0AAA9SS44_BOVIN Computationally mapped isoform of WD repeat-containing protein 18 OS=Bos taurus OX=9913 GN=WDR18 PE=3 SV=1 CANONICAL=Q3SZD4-1" }, "locus": { "chromosome": "7", "start_pos": 43512314, "end_pos": 43504885, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097867.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097867.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086923.1" } ] } }, { "isoform_ac": "A0AAA9TCA8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4/entry#A0AAA9TCA8-1", "sequence": { "sequence": "MAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYICAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGISENIYLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLAWSLCSVLQADPSRTPAPRHVWSRHTLPITDLHCGFGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGILAVTMDLAEHYMFCGGSDGSIFQVDLCTWPGQREKSFQPEQEHGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSQQCLRTVTLKGPVTNACIMLAPVSMLSSDFRPGLPLPHFNKHLLGAEHGDEPHRGGLMLRLGLHQQNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHPTK", "length": 409, "header": "tr|A0AAA9TCA8-1|A0AAA9TCA8_BOVIN Computationally mapped isoform of WD repeat-containing protein 18 OS=Bos taurus OX=9913 GN=WDR18 PE=3 SV=1 CANONICAL=Q3SZD4-1" }, "locus": { "chromosome": "7", "start_pos": 43510098, "end_pos": 43504885, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117804.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117804.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094488.1" } ] } }, { "isoform_ac": "Q3SZD4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4/entry#Q3SZD4-1", "sequence": { "sequence": "MAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYICAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGISENIYLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLAWSLCSVLQADPSRTPAPRHVWSRHTLPITDLHCGFGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGILAVTMDLAEHYMFCGGSDGSIFQVDLCTWPGQREKSFQPEQEHGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSQQCLRTVTLKGPVTNACIMLAPVSMLSSDFRPGLPLPHFNKHLLGAEHGDEPHRGGLMLRLGLHQQGSEPSYLERVEQLQAVMSSTLEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHPTK", "length": 432, "header": "sp|Q3SZD4-1|WDR18_BOVIN Isoform 1 of WD repeat-containing protein 18 OS=Bos taurus OX=9913 GN=WDR18 PE=2 SV=1 CANONICAL=Q3SZD4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533356", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533356", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "Q499N3-1", "protein_name": "WD repeat-containing protein 18", "gene_name": "Wdr18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPMEVVVCTDSAAPLWSCMVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQQGKNYICAWELQRKDQLQQKIMCPGPVTCLTTAPNGLYVLAGIAESIYLWEVSTGNLLVILSRHYQDVSCLKFTGDGSHFVSAGKDCLVLAWSLCSVLQADPSRILAPRHVWSQHTLPITDLHCGFGGPMARVATASLDQTMKLWAISSGDLLLSVLFDMGITSVTMDLAEHYIFCGGSDGSIFQVDLCSRPGPREQSFQPEQNTGKVFKGHRNQVTCLSVSTDGSILLSGSHDESVRLWDVKSKQCVRTVPLKGPVTNAAITLAPPSMLNPEFRPSLPLPHFNKHLLGAEHGDEAQGGGLRLQLGLHLQGKEPSYLERLEQLQAALSGYLEKNMLGSQMLPVRVFELEEEVRSLRKINRDLFDFSTRIITRPSK", "length": 431 }, "evidence": [ { "id": "Q3SZD4", "url": "https://omabrowser.org/oma/group/Q3SZD4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4VBE8-1", "protein_name": "WD repeat-containing protein 18", "gene_name": "Wdr18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPMEVVVCTDAAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQQGKNYICAWELQRKDQLQQKIMCPGPVTCLTTAPNGLYVLAGIAESIYLWEVCTGNLLVILSRHYQDVSCLKFTGDGSHFVSAGKDCLALAWSLCSVLQADPSRILAPRHVWSQHTLPITDLHCGFGGPMARVATASLDQTVKLWAISSGDLLLSVLFDMGITSVTMDLAEHHIFCGGSDGSIFQVDLCSWPGLREHSFQPEQNTGKVFKGHRNQVTCLSVSTDGSVLLSGSHDESVRLWDVKSKQCLRTVTLKGPVTNAAIILAPPSMLNPEFRPSLPLPHFNKHLLGAEHGDEAQGGGLRLQLGLHLQGKEPSYLERLEQLQAVLSSYLEKNMLGSQMLPARVFDLEDEVRSLRKINRDLFDFSTRIITRPSK", "length": 431 }, "evidence": [ { "id": "Q3SZD4", "url": "https://omabrowser.org/oma/group/Q3SZD4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q68EI0-1", "protein_name": "WD repeat-containing protein 18", "gene_name": "wdr18", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAPVEVVLSADSAGQLFNCAVYDPHTGSEFLSYRGGNTSSRSLTILNGEYILGAQLGKNYINVWEIQRKDQLQQKIVCPGIVTCLCASPDGLYVLAGIAEAIYLWEVSTGNLLAILSRHFQDLSCIKFTDDSSHFVSGGKDNLAFIWNLSSVVQLDSSRTPEPRHILSRHSLPITDIHCGLMGPQARVATASLDQTVKVWEISSGEMLLSVLFDVGIMSVTFDPCEYFLFCGGSDGNIFQVSLCSTSLSRDKTFQSDSEGNQVFKGHRNLVTCLSVSMDGTVLLSGSNDETVRMWDVQSKQCIWTINHRGPVTNAAIIPAPANMFLSDSHPAVPLPRFSRHLNPSEQGDGTGTGGMSLRLGANTQEPEGTYLEKAEELYSLMCAVTDKSVFGDGENTKVRVSELEEEVRTLKKINKDLYEFSTQLLTKPN", "length": 431 }, "evidence": [ { "id": "Q3SZD4", "url": "https://omabrowser.org/oma/group/Q3SZD4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BV38-1", "protein_name": "WD repeat-containing protein 18", "gene_name": "WDR18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSLPLPHFNKHLLGAEHGDEPRHGGLTLRLGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRPAK", "length": 432 }, "evidence": [ { "id": "Q3SZD4", "url": "https://omabrowser.org/oma/group/Q3SZD4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M3B4-1", "protein_name": "Protein ROOT INITIATION DEFECTIVE 3", "gene_name": "RID3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEITVIASSSIDEGIGSWDLKTGTEQLQFKPCASPAHGLTAVGEKFLASSQLSARNTSGSIFYWSWTKPQAEVKSYPVEPIKALAANNEGTYLVGGGISGDIYLWEVATGKLLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQRQQGNTLYEHNFNEHTMSVTDIVIDYGGCNAVIISSSEDRTCKVWSLSRGKLLKNIIFPSVINALALDPGGCVFYAGARDSKIYIGAINATSEYGTQVLGSVSEKGKAITCLAYCADGNLLISGSEDGVVCVWDPKSLRHVRTLIHAKGSRKGPVNNIQIVRKTIVANSNKTQVSWKSRGALIPPPLEKYERPVEDTMDGIVTVDPPPFSDVPVYSSFLSADLIDEQVKELQQQGSAATEMEMERLKLEYKRSLQMNEQWQKNYENLLQVVMEEEQIGGTN", "length": 438 }, "evidence": [ { "id": "Q3SZD4", "url": "https://omabrowser.org/oma/group/Q3SZD4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear pre-replicative complex", "id": "GO:0005656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005656", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" }, { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" }, { "name": "rixosome complex", "id": "GO:0120330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120330", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "Q3SZD4", "url": "https://www.uniprot.org/uniprotkb/Q3SZD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 432, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZD4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDM0-1", "uniprot_ac": "Q2YDM0", "uniprot_id": "TM248_BOVIN", "mass": { "chemical_mass": 35068.0, "monoisotopic_mass": 35068.0 }, "refseq": { "ac": "NP_001039546", "name": "transmembrane protein 248", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" }, "gene_names": [ { "name": "TMEM248", "type": "recommended", "evidence": [ { "id": "Q2YDM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0" } ] }, { "name": "C25H7orf42", "type": "synonym", "evidence": [ { "id": "NP_001039546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" } ] }, { "name": "C7orf42", "type": "synonym", "evidence": [ { "id": "NP_001039546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" } ] }, { "name": "TMEM248", "type": "synonym", "evidence": [ { "id": "NP_001039546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" } ] } ], "protein_names": [ { "name": "Transmembrane protein 248", "type": "recommended", "evidence": [ { "id": "Q2YDM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0/entry#names_and_taxonomy" } ] }, { "name": "UPF0458 protein C7orf42 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" } ] }, { "name": "transmembrane protein 248", "type": "synonym", "evidence": [ { "id": "NP_001039546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDM0", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM248", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0", "locus": { "chromosome": "25", "start_pos": 28317971, "end_pos": 28309282, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002935", "url": "https://www.ensembl.org/id/ENSBTAG00000002935" } ] } } ], "crossref": [ { "id": "Q2YDM0", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002935", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002935", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511252", "url": "https://www.ncbi.nlm.nih.gov/gene/511252", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039493", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039493", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511252", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511252", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TLFCYAI", "url": "https://omabrowser.org/oma/group/TLFCYAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDM0", "url": "https://www.orthodb.org/?gene=Q2YDM0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16002:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16002:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14940", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14940", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039546", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DHX5", "url": "https://www.uniprot.org/uniprotkb/A0A452DHX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSX5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSX5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM0", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFNINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTAAPESTVTSGQARTSTQSPQPLEDAGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAQEEINITFTLPTSWSSDDCALHGHCEQVVFTACMTLTAHPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 314, "header": "sp|Q2YDM0-1|TM248_BOVIN Isoform 1 of Transmembrane protein 248 OS=Bos taurus OX=9913 GN=TMEM248 PE=2 SV=1 CANONICAL=Q2YDM0-1" }, "isoforms": [ { "isoform_ac": "A0A452DHX5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0/entry#A0A452DHX5-1", "sequence": { "sequence": "MFNINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTAAPESTVTSGQARTSTQSPQPLEDAGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGTLSGSQLPQALSGHSCYHTEYETPCLAPFSCRQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVSDACVWLPGFGAGPRPPVGELVGLSYLLVTA", "length": 322, "header": "tr|A0A452DHX5-1|TM248_BOVIN Computationally mapped isoform of Transmembrane protein 248 OS=Bos taurus OX=9913 GN=TMEM248 PE=2 SV=1 CANONICAL=Q2YDM0-1" }, "locus": { "chromosome": "25", "start_pos": 28317968, "end_pos": 28309310, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003816.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003816.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003816.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003816.6" } ] } }, { "isoform_ac": "A0ABI0NSX5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0/entry#A0ABI0NSX5-1", "sequence": { "sequence": "GVLSPPRRRRTPGVGGQGGVVRGVFFYPETTEAGPGDETVSRRREPDWPLVLASAPRSRTLPPARRGEWCRAAPGRPRAAASELRAAAGVRRAAGPAGPGARRCPPGRGGADQNNVQHQPPGEPEAVHQQPAPLGGVYDQCQRHGNSFPDLGLFLQNQGDQVTRNGRENETLKHLTNDTAAPESTVTSGQARTSTQSPQPLEDAGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAQEEINITFTLPTSWSSDDCALHGHCEQVVFTACMTLTAHPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 411, "header": "tr|A0ABI0NSX5-1|A0ABI0NSX5_BOVIN Computationally mapped isoform of Transmembrane protein 248 OS=Bos taurus OX=9913 GN=TMEM248 PE=3 SV=1 CANONICAL=Q2YDM0-1" }, "locus": { "chromosome": "25", "start_pos": 28318016, "end_pos": 28293589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141321.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141321.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106194.1" } ] } }, { "isoform_ac": "Q2YDM0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0/entry#Q2YDM0-1", "sequence": { "sequence": "MFNINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTAAPESTVTSGQARTSTQSPQPLEDAGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAQEEINITFTLPTSWSSDDCALHGHCEQVVFTACMTLTAHPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 314, "header": "sp|Q2YDM0-1|TM248_BOVIN Isoform 1 of Transmembrane protein 248 OS=Bos taurus OX=9913 GN=TMEM248 PE=2 SV=1 CANONICAL=Q2YDM0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511252", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511252", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RVT9-1", "protein_name": "Transmembrane protein 248", "gene_name": "TMEM248", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVNINLLENLKVYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMTEDWNTFLLRFNDLDFCISENETLKHLINDTTTPESTVTSGQARSSTQSPQTLEDSGPINISVTITLTLDPLRPFGGYSRNITHLSSTIFGHQIGLSGRESHEEINITFTLPAAWNSDDCVLHGHCEQVVFTTCMTVTAASNVFPVTVQPPHCVPETYSNATLWYKIFTTARDSNTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNTEFCSEKVALSEA", "length": 314 }, "evidence": [ { "id": "Q2YDM0", "url": "https://omabrowser.org/oma/group/Q2YDM0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RJI0-1", "protein_name": "Transmembrane protein 248", "gene_name": "TMEM248", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRIMFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARTSTQSPQSLEDSGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPTAWSSDDCALHAHCEQVVFTACMTLTANPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 317 }, "evidence": [ { "id": "Q2YDM0", "url": "https://omabrowser.org/oma/group/Q2YDM0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TBN1-1", "protein_name": "Transmembrane protein 248", "gene_name": "Tmem248", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTVGQARSSTQPPQSLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNADDCALHGHCEQAVFTACMTLTAAPGVFPVTVQPPHCIPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVVVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 314 }, "evidence": [ { "id": "Q2YDM0", "url": "https://omabrowser.org/oma/group/Q2YDM0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AY76-1", "protein_name": "Transmembrane protein 248", "gene_name": "Tmem248", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQSLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA", "length": 314 }, "evidence": [ { "id": "Q2YDM0", "url": "https://omabrowser.org/oma/group/Q2YDM0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NWD8-1", "protein_name": "Transmembrane protein 248", "gene_name": "TMEM248", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSINPLENLKVYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARASTQSPQALEDSGPVNISVSITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPTAWSSDDCALHGHCEQVVFTACMTLTASPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALAEA", "length": 314 }, "evidence": [ { "id": "Q2YDM0", "url": "https://omabrowser.org/oma/group/Q2YDM0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM0", "url": "https://www.uniprot.org/uniprotkb/Q2YDM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDM0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDM0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDM0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 157, "end_pos": 159 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LI5-1", "uniprot_ac": "Q32LI5", "uniprot_id": "MEIG1_BOVIN", "mass": { "chemical_mass": 10839.0, "monoisotopic_mass": 10839.0 }, "refseq": { "ac": "NP_001107996", "name": "meiosis expressed gene 1 protein homolog isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996" }, "gene_names": [ { "name": "MEIG1", "type": "recommended", "evidence": [ { "id": "Q32LI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ] }, { "name": "MEIG1", "type": "synonym", "evidence": [ { "id": "NP_001107996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996" } ] } ], "protein_names": [ { "name": "Meiosis expressed gene 1 protein homolog", "type": "recommended", "evidence": [ { "id": "Q32LI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LI5/entry#names_and_taxonomy" } ] }, { "name": "meiosis expressed gene 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001107996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996" } ] }, { "name": "meiosis expressed gene 1 protein homolog isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001107996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996" } ] }, { "name": "meiosis expressed gene 1 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001107996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996" } ] } ], "function": [ { "annotation": "Essential for spermiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DHX9", "url": "https://www.uniprot.org/uniprotkb/A0A452DHX9#function" }, { "database": "UniProtKB", "id": "ARBA00003351", "url": "https://www.uniprot.org/uniprotkb/ARBA00003351#function" }, { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEIG1", "url": "https://www.uniprot.org/uniprotkb/Q32LI5", "locus": { "chromosome": "13", "start_pos": 29612566, "end_pos": 29595917, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002856", "url": "https://www.ensembl.org/id/ENSBTAG00000002856" } ] } } ], "crossref": [ { "id": "Q32LI5", "url": "https://alphafold.ebi.ac.uk/entry/Q32LI5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002856", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002856", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617353", "url": "https://www.ncbi.nlm.nih.gov/gene/617353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617353", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQVSMID", "url": "https://omabrowser.org/oma/group/KQVSMID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHX9", "url": "https://www.orthodb.org/?gene=A0A452DHX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32LI5", "url": "https://www.orthodb.org/?gene=Q32LI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17008", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17008", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17008:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17008:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15163", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15163", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001107996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107996", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DHX9", "url": "https://www.uniprot.org/uniprotkb/A0A452DHX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHX9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LI5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVSMVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY", "length": 88, "header": "sp|Q32LI5-1|MEIG1_BOVIN Isoform 1 of Meiosis expressed gene 1 protein homolog OS=Bos taurus OX=9913 GN=MEIG1 PE=3 SV=1 CANONICAL=Q32LI5-1" }, "isoforms": [ { "isoform_ac": "A0A452DHX9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LI5/entry#A0A452DHX9-1", "sequence": { "sequence": "MAERGLPLRAGPKEILSKKTCVAMANSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVSMVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY", "length": 111, "header": "tr|A0A452DHX9-1|MEIG1_BOVIN Computationally mapped isoform of Meiosis expressed gene 1 protein homolog OS=Bos taurus OX=9913 GN=MEIG1 PE=3 SV=1 CANONICAL=Q32LI5-1" }, "locus": { "chromosome": "13", "start_pos": 29612373, "end_pos": 29596065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003703.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003703.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003703.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003703.4" } ] } }, { "isoform_ac": "Q32LI5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LI5/entry#Q32LI5-1", "sequence": { "sequence": "MANSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVSMVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY", "length": 88, "header": "sp|Q32LI5-1|MEIG1_BOVIN Isoform 1 of Meiosis expressed gene 1 protein homolog OS=Bos taurus OX=9913 GN=MEIG1 PE=3 SV=1 CANONICAL=Q32LI5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617353", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JV95-1", "protein_name": "Meiosis/spermiogenesis associated 1", "gene_name": "Meig1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVAMVDRWPETGYVKKLQRRDNTFYYYNKQRECEDKEVHKVKIYAY", "length": 88 }, "evidence": [ { "id": "Q32LI5", "url": "https://omabrowser.org/oma/group/Q32LI5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZWX5-1", "protein_name": "Meiosis/spermiosis associated 1", "gene_name": "MEIG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVSVVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY", "length": 88 }, "evidence": [ { "id": "Q32LI5", "url": "https://omabrowser.org/oma/group/Q32LI5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7I275-1", "protein_name": "Meiosis expressed gene 1 protein homolog", "gene_name": "Meig1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVAMVDRWPETGYVKKLQRRDNTFYYYNKQRECEDKEVHKVKIYAY", "length": 88 }, "evidence": [ { "id": "Q32LI5", "url": "https://omabrowser.org/oma/group/Q32LI5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5JSS6-1", "protein_name": "Meiosis expressed gene 1 protein homolog", "gene_name": "MEIG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSDVKPKSVSHAKKWSEEIENLYRFQQAGYRDETEYRQVKQVSMVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY", "length": 88 }, "evidence": [ { "id": "Q32LI5", "url": "https://omabrowser.org/oma/group/Q32LI5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5RGE4-1", "protein_name": "Meiosis expressed gene 1 protein homolog", "gene_name": "meig1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MACAVLLDNNAKPKSMSRAKQWTGEVENLYRFQQAGYRDELEYRQIKQAEIDRWPDTGFVKKLQRRDNTFYYYNRKRECEDREVHKVKVYAY", "length": 92 }, "evidence": [ { "id": "Q32LI5", "url": "https://omabrowser.org/oma/group/Q32LI5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32LI5", "url": "https://www.uniprot.org/uniprotkb/Q32LI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LI5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 88, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LI5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LI5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBS0-1", "uniprot_ac": "Q3ZBS0", "uniprot_id": "DCAKD_BOVIN", "mass": { "chemical_mass": 26384.0, "monoisotopic_mass": 26384.0 }, "refseq": {}, "gene_names": [ { "name": "DCAKD", "type": "recommended", "evidence": [ { "id": "Q3ZBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ] } ], "protein_names": [ { "name": "Dephospho-CoA kinase domain-containing protein", "type": "recommended", "evidence": [ { "id": "Q3ZBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCAKD", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0", "locus": { "chromosome": "19", "start_pos": 44717125, "end_pos": 44737320, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006048", "url": "https://www.ensembl.org/id/ENSBTAG00000006048" } ] } } ], "crossref": [ { "id": "Q3ZBS0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006048", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006048", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02022", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02022", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508778", "url": "https://www.ncbi.nlm.nih.gov/gene/508778", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508778", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508778", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQMDIEQ", "url": "https://omabrowser.org/oma/group/CQMDIEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI42", "url": "https://www.orthodb.org/?gene=A0A452DI42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBS0", "url": "https://www.orthodb.org/?gene=Q3ZBS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10695:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10695:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01121", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01121", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196783", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196783", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI42", "url": "https://www.uniprot.org/uniprotkb/A0A452DI42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI42-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS0-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNNLSREDAEARIKAQLPLKDKARMARHVLDNSGEWSVTKRQVVLLHAELEHSLEYLPLRLGVLTGLAGIVGLLYLLTHYLLPSP", "length": 231, "header": "sp|Q3ZBS0-1|DCAKD_BOVIN Isoform 1 of Dephospho-CoA kinase domain-containing protein OS=Bos taurus OX=9913 GN=DCAKD PE=2 SV=2 CANONICAL=Q3ZBS0-1" }, "isoforms": [ { "isoform_ac": "A0A452DI42-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#A0A452DI42-1", "sequence": { "sequence": "MSEVVTAPASLNENEPGQISTSRSFRRSCGGPSPLGSLAPVTPDSWFLVSPTSLLPGKMFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNNLSREDAEARIKAQLPLKDKARMARHVVDNSGEWSVTKRQVVLLHAELEHSLEYLPLRLGVLTGLAGIVGLLYLLTHYLLPSP", "length": 289, "header": "tr|A0A452DI42-1|DCAKD_BOVIN Computationally mapped isoform of Dephospho-CoA kinase domain-containing protein OS=Bos taurus OX=9913 GN=DCAKD PE=2 SV=2 CANONICAL=Q3ZBS0-1" }, "locus": { "chromosome": "19", "start_pos": 44730239, "end_pos": 44718108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007945.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007945.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007945.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007945.6" } ] } }, { "isoform_ac": "A0AAA9SPY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#A0AAA9SPY8-1", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVY", "length": 134, "header": "tr|A0AAA9SPY8-1|A0AAA9SPY8_BOVIN Computationally mapped isoform of Dephospho-CoA kinase domain containing OS=Bos taurus OX=9913 GN=DCAKD PE=4 SV=1 CANONICAL=Q3ZBS0-1" }, "locus": { "chromosome": "19", "start_pos": 44726905, "end_pos": 44721640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087436.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087436.1" } ] } }, { "isoform_ac": "A0AAA9TR16-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#A0AAA9TR16-1", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNNLSREDAEARIKAQLPLKDKARMARHVVDNSGEWSVTKRQVVLLHAELEHSLEYLPLRLGVLTGLAGIVGLLYLLTHYLLPSP", "length": 231, "header": "tr|A0AAA9TR16-1|A0AAA9TR16_BOVIN Computationally mapped isoform of Dephospho-CoA kinase domain-containing protein OS=Bos taurus OX=9913 GN=DCAKD PE=3 SV=1 CANONICAL=Q3ZBS0-1" }, "locus": { "chromosome": "19", "start_pos": 44726905, "end_pos": 44718108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088907.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088907.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099453.1" } ] } }, { "isoform_ac": "Q3ZBS0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#Q3ZBS0-1", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNNLSREDAEARIKAQLPLKDKARMARHVLDNSGEWSVTKRQVVLLHAELEHSLEYLPLRLGVLTGLAGIVGLLYLLTHYLLPSP", "length": 231, "header": "sp|Q3ZBS0-1|DCAKD_BOVIN Isoform 1 of Dephospho-CoA kinase domain-containing protein OS=Bos taurus OX=9913 GN=DCAKD PE=2 SV=2 CANONICAL=Q3ZBS0-1" }, "locus": {} }, { "isoform_ac": "Q3ZBS0-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0/entry#Q3ZBS0-2", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDIIARHIVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRHLLNSITHPEICKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYW", "length": 135, "header": "sp|Q3ZBS0-2|DCAKD_BOVIN Isoform 2 of Dephospho-CoA kinase domain-containing protein OS=Bos taurus OX=9913 GN=DCAKD PE=2 SV=2 CANONICAL=Q3ZBS0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508778", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508778", "resource": "KEGG Pathway" }, { "id": "R-BTA-196783", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196783", "resource": "Reactome", "description": "Coenzyme A biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P2N1-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "DCAKD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFLVGLSGGIASGKSTVVAVLRELGCAVIDADVIAREVVQPRLKAYQQIVRYFGPEILLESGEINREALGSIIFSQPEKRRLLNAITHPEIQKEMLKQVLKYFVLGYRYVILDIPLLFETKRLTKFMKHTILVYCDPQTQLARLRKRSGLSQAEAEARIASQLPLDEKRRMATHVIDNSGDRESTRQQVLRLHARLEGSLDFLWARLAVGTAVAALGGLLYILLQHFIS", "length": 229 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RR05-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "DCAKD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFLVGLTGGIASGKSSVLQVLQQLGCAVIDVDVIARHVVQPGYPAHRRIVEAFGTEVLLENGDIDRKALGDLIFNQPDRRHLLNAITHPEICREMTKETFKYFLRGYRYVILDVPLLFETKKLLKYMKHTVVVYCDRDTQLARLMQRNNLKQEDAEARIKAQLPLEDKARMARHVLDNSGEWSVTKRQVVLLHAELERSLEYLPLRLGVLAGLAGIVSLLYLLTHYLLASL", "length": 231 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HLM0-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dcakd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDVIARHVVQPGYPAHRRIVQAFGTEVLLENGDIDRKVLGDLIFNQPDRRQLLNSITHPEIRKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMKRNSLKREDAEARVNAQLPLKDKARMANHVLDNSGEWSLTRRQVILLHAKLERSMEYLPLRLGFLTGLAGIASLLYLLTRYLLPSP", "length": 231 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q03941-1", "protein_name": "Dephospho-CoA kinase CAB5", "gene_name": "CAB5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLVVGLTGGIACGKSTVSRRLRDKYKLPIVDADKIARQVVEPGQNAYDQIVLYFKDKIPNLLLEDGHLNREALGKWVFSHKEDLQALNGITHPAIRYAMFKEIGYYYLKGYRMCVLDVPLLFEGNLDSICGVTVSVICTQELQLERLMTRNPELSEEDAKNRLNSQMSTEERMARSDYILQNNSTLVDLYEQIESVVKKIQPSKLRTVLEYFPPFGAVSASSIVMSRLLMKKLQNKKSSAV", "length": 241 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q0P4C4-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "dcakd", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFLVGLTGGIASGKSTVSSQLKELGCPVIDADVVARKVVEPQTAAYRLIVRHFGQEVLSENGEIDRKKLGQIIFSSPEKRRLLNSITHPEIHKEMLKQILLYFIKGYRYVILNVPLLFETRRLTRFLTHTVVVYCDPATQLSRLMQRDALSQTEAEQRISAQMPLKEKRGLANHVIENSGSREDTHRQVLRLHSKLDDCMQFLIIRAVAVAALTGLGGLFIYTVKIITS", "length": 229 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AY55-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dcakd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDVIARHIVQPGCPAHRRIVEAFGTEVLLENGDINRKVLGDLIFNQPDRRQLLNSITHPEIRKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMKRNNLNREDAEARINSQLPLKDKARMANHVLDNSGEWSLTRRQVILLHAKLERSMEYLPLRLGFLTGLAGIASLLYLLTRYLLPSPQLGNPGSKP", "length": 240 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHC4-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dcakd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDVIARHVVQPGYPAHRRIVEAFGTEVLLENGDIDRKVLGDLIFNQPDRRQLLNSITHPEIRKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMKRNNLNREDAEARINAQLPLKDKARMANHVLDNSGEWSLTRRQAILLHAKLERSMEYLPLRLGFLTGLAGIASLLYLLTRYLLPSP", "length": 231 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WVC6-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "DCAKD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDVMARHVVQPGYPAHRRIVEVFGTEVLLENGDINRKVLGDLIFNQPDRRQLLNAITHPEIRKEMMKETFKYFLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNSLNRKDAEARINAQLPLTDKARMARHVLDNSGEWSVTKRQVILLHTELERSLEYLPLRFGVLTGLAAIASLLYLLTHYLLPYA", "length": 231 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VI57-1", "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dpck", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFIVAVTGGIATGKSTISKVFERQGIPVIDADKIAREIVEPGQPCWRQIREVFGDEVLLPSKEINRAVLGKMIFEDKELRGKLNKITHPTIHRKIFWQVCKLLVTGHAWIVLDLPLLFETGVLMDFIHKIVCVTCDSDKQLERLIARNELSESEARHRVDSQMPLDKKCEKSHFVIDNNGSVEEAESSAMSIYNLMRDSKQHWLNRISFLGLFLIVGFTIYMLLKVFNRLPESWQM", "length": 236 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZQH0-1", "protein_name": "Dephospho-CoA kinase", "gene_name": "COAE", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRIVGLTGGIASGKSTVSNLFKASGIPVVDADVVARDVLKKGSGGWKRVVAAFGEEILLPSGEVDRPKLGQIVFSSDSKRQLLNKLMAPYISSGIFWEILKQWASGAKVIVVDIPLLFEVKMDKWTKPIVVVWVSQETQLKRLMERDGLSEEDARNRVMAQMPLDSKRSKADVVIDNNGSLDDLHQQFEKVLIEIRRPLTWIEFWRSRQGAFSVLGSVILGLSVCKQLKIGS", "length": 232 }, "evidence": [ { "id": "Q3ZBS0", "url": "https://omabrowser.org/oma/group/Q3ZBS0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dephospho-CoA kinase activity", "id": "GO:0004140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004140", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "coenzyme A biosynthetic process", "id": "GO:0015937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015937", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBS0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 231, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBS0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBS0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KL7-1", "uniprot_ac": "Q32KL7", "uniprot_id": "SPESP_BOVIN", "mass": { "chemical_mass": 41410.0, "monoisotopic_mass": 41410.0 }, "refseq": { "ac": "NP_001073241", "name": "sperm equatorial segment protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073241" }, "gene_names": [ { "name": "SPESP1", "type": "recommended", "evidence": [ { "id": "Q32KL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ] }, { "name": "SPESP1", "type": "synonym", "evidence": [ { "id": "NP_001073241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073241" } ] } ], "protein_names": [ { "name": "Sperm equatorial segment protein 1", "type": "recommended", "evidence": [ { "id": "Q32KL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL7/entry#names_and_taxonomy" } ] }, { "name": "sperm equatorial segment protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001073241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073241" } ] } ], "function": [ { "annotation": "Involved in fertilization ability of sperm.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DI77", "url": "https://www.uniprot.org/uniprotkb/A0A452DI77#function" }, { "database": "UniProtKB", "id": "ARBA00003615", "url": "https://www.uniprot.org/uniprotkb/ARBA00003615#function" }, { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7#function" }, { "database": "UniProtKB", "id": "Q9D5A0", "url": "https://www.uniprot.org/uniprotkb/Q9D5A0#function" }, { "database": "UniProtKB", "id": "A0AAA9RUR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUR3#function" }, { "database": "UniProtKB", "id": "A0AAA9SQA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPESP1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7", "locus": { "chromosome": "10", "start_pos": 15791755, "end_pos": 15763559, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005994", "url": "https://www.ensembl.org/id/ENSBTAG00000005994" } ] } } ], "crossref": [ { "id": "Q32KL7", "url": "https://alphafold.ebi.ac.uk/entry/Q32KL7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513571", "url": "https://www.ncbi.nlm.nih.gov/gene/513571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513571", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TESTAFW", "url": "https://omabrowser.org/oma/group/TESTAFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KL7", "url": "https://www.orthodb.org/?gene=Q32KL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31667", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31667", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31667:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31667:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073241", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI77", "url": "https://www.uniprot.org/uniprotkb/A0A452DI77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI77-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KL7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFLVLLVALLLWPSSLPAYRRVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS", "length": 366, "header": "sp|Q32KL7-1|SPESP_BOVIN Isoform 1 of Sperm equatorial segment protein 1 OS=Bos taurus OX=9913 GN=SPESP1 PE=2 SV=1 CANONICAL=Q32KL7-1" }, "isoforms": [ { "isoform_ac": "A0A452DI77-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7/entry#A0A452DI77-1", "sequence": { "sequence": "MMPMKFLVLLVALLLWPSSLPAYRRVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS", "length": 369, "header": "tr|A0A452DI77-1|SPESP_BOVIN Computationally mapped isoform of Sperm equatorial segment protein 1 OS=Bos taurus OX=9913 GN=SPESP1 PE=2 SV=1 CANONICAL=Q32KL7-1" }, "locus": { "chromosome": "10", "start_pos": 15791551, "end_pos": 15763687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007865.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007865.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007865.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007865.6" } ] } }, { "isoform_ac": "A0AAA9RUR3-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7/entry#A0AAA9RUR3-1", "sequence": { "sequence": "AGLGTWDTLGRDNPCSPGLVYRRVAAGVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS", "length": 371, "header": "tr|A0AAA9RUR3-1|A0AAA9RUR3_BOVIN Computationally mapped isoform of Sperm equatorial segment protein 1 OS=Bos taurus OX=9913 GN=SPESP1 PE=3 SV=1 CANONICAL=Q32KL7-1" }, "locus": { "chromosome": "10", "start_pos": 15791551, "end_pos": 15763993, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074817.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074817.1" } ] } }, { "isoform_ac": "A0AAA9SQA2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7/entry#A0AAA9SQA2-1", "sequence": { "sequence": "EHPAWLLIFQGVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS", "length": 355, "header": "tr|A0AAA9SQA2-1|A0AAA9SQA2_BOVIN Computationally mapped isoform of Sperm equatorial segment protein 1 OS=Bos taurus OX=9913 GN=SPESP1 PE=3 SV=1 CANONICAL=Q32KL7-1" }, "locus": { "chromosome": "10", "start_pos": 15791551, "end_pos": 15766974, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104654.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104654.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087546.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087546.1" } ] } }, { "isoform_ac": "Q32KL7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL7/entry#Q32KL7-1", "sequence": { "sequence": "MKFLVLLVALLLWPSSLPAYRRVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS", "length": 366, "header": "sp|Q32KL7-1|SPESP_BOVIN Isoform 1 of Sperm equatorial segment protein 1 OS=Bos taurus OX=9913 GN=SPESP1 PE=2 SV=1 CANONICAL=Q32KL7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 129, "start_aa": "Asn", "end_pos": 129, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn129", "evidence": [ { "id": "Q32KL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 24, "start_aa": "Thr", "end_pos": 24, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513571", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513571", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T5L6-1", "protein_name": "Sperm equatorial segment protein 1", "gene_name": "SPESP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKFLVLLVALLLWPSSLQAYPRITVTPEEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNVNSVGPRVSKFREIITHEEGSAENDVLINPVTEETTTFPTRGFTLEIEKQRSTKSTAFWSIKPNNISVVLHAKEPYIEKEELEPEPEPTVSQTEPGKSSPDVHESFTSQVVTPSTKDIDLNTIPEDVPQLSGDYEWENPEPENPYNEDILKKISDIDSQVQQVPLPESFKPEYRADIQASKEHLKRSLALAAAAEHKLEKMYKSQMLPLGRSSGGIDDIETVINMLYNSRSKLSEYLDIQYVPPEMRKKAIAVFSILKNILCVNKGETQNLIRKLLNNNIKIINLLNIP", "length": 352 }, "evidence": [ { "id": "Q32KL7", "url": "https://omabrowser.org/oma/group/Q32KL7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0JPP4-1", "protein_name": "Sperm equatorial segment protein 1", "gene_name": "Spesp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPVVLVALLWLWPSSFLAYPTATVLPDEEQNLNHYVQILQNLIMSVPTKEQGFGRKFRSSRTVDGAEARSLSSEMLLTPGLVSAQEVTTPETEVMLTSMVEKTTFPSSGFTMESEKRRTHSKAFWSIQPNNVSIVLHTEEPYIEKEPEPEPELETEEESRRLATEPEPEPESESAPETETRQTAESEEEVETSTAQNKVRTGTSRMSTVITQTTNTQGTPNTVTVKTINNLDVSTESEDVPQLSGQSEILNVEDLPGHHSLSTRHENILRKISNINSQIHQGLLSDHSSPAYKEFIKASREHLKRSLALAAAAEHKLQQMYGSNVFLDGHTSDPDDDMEVIINMLYNSRSKLSDYFTINHVPSELREKATVVIAVLKKILCVDQVEMQSLIRKLLSNNMKILNILNVP", "length": 409 }, "evidence": [ { "id": "Q32KL7", "url": "https://omabrowser.org/oma/group/Q32KL7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UW49-1", "protein_name": "Sperm equatorial segment protein 1", "gene_name": "SPESP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPLVLLVALLLWPSSVPAYPSITVTPDEEQNLNHYIQVLENLVRSVPSGEPGREKKSNSPKHVYSIASKGSKFKELVTHGDASTENDVLTNPISEETTTFPTGGFTPEIGKKKHTESTPFWSIKPNNVSIVLHAEEPYIENEEPEPEPEPAAKQTEAPRMLPVVTESSTSPYVTSYKSPVTTLDKSTGIGISTESEDVPQLSGETAIEKPEEFGKHPESWNNDDILKKILDINSQVQQALLSDTSNPAYREDIEASKDHLKRSLALAAAAEHKLKTMYKSQLLPVGRTSNKIDDIETVINMLCNSRSKLYEYLDIKCVPPEMREKAATVFNTLKNMCRSRRVTALLKVY", "length": 350 }, "evidence": [ { "id": "Q32KL7", "url": "https://omabrowser.org/oma/group/Q32KL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D5A0-1", "protein_name": "Sperm equatorial segment protein 1", "gene_name": "Spesp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLVVLVALWLWPSSLLAYPTITVLPDEEQNLNHYVHILQNLIMSVPTKEQDLGKKLSSSRTVDSAEPRSLASKVLLTPGLVSAQDVTPESDVLIRPVDETTNSRTRGFTLRRRRTQSTAFWSIRPNNISVVLRTEEPFIEKEPEPELESSRLPTEPEPELEPEPEPVAESRQMSEPEEELVTSTTPNKELTGTSRISSMATQPANTQATRITVTVKTTSTMDVSTDSEDVPQLSGQSEIPSAEDLPGRHSLNTRHEDILKKISNINAEIQQGLLGGNNSPEFKEFIKASREHLKRSLALAAAAEHKLEQMYGSNVFPEGRTSDPDNDMEMIINMLYNSRSKLSDYFNIKRVPSELREKASVVNAELRKILCVDQVEMQSLIKKLLSNNMKILNILNVP", "length": 399 }, "evidence": [ { "id": "Q32KL7", "url": "https://omabrowser.org/oma/group/Q32KL7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "sperm-egg recognition", "id": "GO:0035036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035036", "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "pmid": "" }, { "name": "acrosome reaction", "id": "GO:0007340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q32KL7", "url": "https://www.uniprot.org/uniprotkb/Q32KL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KL7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 366, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KL7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KL7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 129 ], "o_linked_sites": [ 24 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CW4-1", "uniprot_ac": "Q58CW4", "uniprot_id": "NMUR2_BOVIN", "mass": { "chemical_mass": 46343.0, "monoisotopic_mass": 46343.0 }, "refseq": { "ac": "NP_001030220", "name": "neuromedin-U receptor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030220" }, "gene_names": [ { "name": "NMUR2", "type": "recommended", "evidence": [ { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ] }, { "name": "NMUR2", "type": "synonym", "evidence": [ { "id": "NP_001030220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030220" } ] } ], "protein_names": [ { "name": "Neuromedin-U receptor 2", "type": "recommended", "evidence": [ { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4/entry#names_and_taxonomy" } ] }, { "name": "NMU-R2", "type": "synonym", "evidence": [ { "id": "NP_001030220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030220" }, { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4/entry#names_and_taxonomy" } ] }, { "name": "neuromedin-U receptor 2", "type": "synonym", "evidence": [ { "id": "NP_001030220", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030220" } ] } ], "function": [ { "annotation": "G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (By similarity). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4#function" }, { "database": "UniProtKB", "id": "P12760", "url": "https://www.uniprot.org/uniprotkb/P12760#function" }, { "database": "UniProtKB", "id": "Q9ESQ4", "url": "https://www.uniprot.org/uniprotkb/Q9ESQ4#function" }, { "database": "UniProtKB", "id": "Q9GZQ4", "url": "https://www.uniprot.org/uniprotkb/Q9GZQ4#function" } ] }, { "annotation": "Receptor for the neuromedin-U and neuromedin-S neuropeptides.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DII4", "url": "https://www.uniprot.org/uniprotkb/A0A452DII4#function" }, { "database": "UniProtKB", "id": "ARBA00003593", "url": "https://www.uniprot.org/uniprotkb/ARBA00003593#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NMUR2", "url": "https://www.uniprot.org/uniprotkb/Q58CW4", "locus": { "chromosome": "7", "start_pos": 63636150, "end_pos": 63653855, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011131", "url": "https://www.ensembl.org/id/ENSBTAG00000011131" } ] } } ], "crossref": [ { "id": "Q58CW4", "url": "https://alphafold.ebi.ac.uk/entry/Q58CW4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011131", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011131", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507439", "url": "https://www.ncbi.nlm.nih.gov/gene/507439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507439", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507439", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DII4", "url": "https://www.orthodb.org/?gene=A0A452DII4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CW4", "url": "https://www.orthodb.org/?gene=Q58CW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24243:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24243:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19285", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19285", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030220", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DII4", "url": "https://www.uniprot.org/uniprotkb/A0A452DII4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DII4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DII4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CW4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKHENVSWMYQQELKDPFKKYLNNTDDYLALLCGPRRSHLFLPVTAVYALIFVVGVVGNLLVCLVILRHQTMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAVLHPFRAKLKSTRGRALRILGIVWGLSVLFSLPNTSIHGIKLHYFPNGSIIPGSATCTVIKPMWIYNFIIQVTSLLFYILPMTVISVLYYLMGLKLKKDQHLEADKVTANIQRPSRKSVTKMLFVLVLVFAICWAPFHIDRLFFSFVEEWTEPLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSHRFQAAFRTVIPPSCQQQHSHNHSPGPSMQRNIFLTECHLVELTEDVAPQFPRQLSVLSSQLPTALCTGQVPRKELAKS", "length": 407, "header": "sp|Q58CW4-1|NMUR2_BOVIN Isoform 1 of Neuromedin-U receptor 2 OS=Bos taurus OX=9913 GN=NMUR2 PE=2 SV=1 CANONICAL=Q58CW4-1" }, "isoforms": [ { "isoform_ac": "A0A452DII4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW4/entry#A0A452DII4-1", "sequence": { "sequence": "IAVMEKHENVSWMYQQELKDPFKKYLNNTDDYLALLCGPRRSHLFLPVTAVYTLIFVVGVVGNLLVCLVILRHQTMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAVLHPFRAKLKSTRGRALRILGIVWGLSVLFSLPNTSIHGIKLHYFPNGSIIPGSATCTVIKPMWIYNFIIQVTSLLFYILPMTVISVLYYLMGLKLKKDQHLEADKVTANIQRPSRKSVTKMLFVLVLVFAICWAPFHIDRLFFSFVEEWTEPLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSHRFQAAFRTVIPPSCQQQHSHNHSPGPSMQRNIFLTECHLVELTEDVAPQFPRQLSVLSSQLPTALCTGQVPRKELAKS", "length": 410, "header": "tr|A0A452DII4-1|NMUR2_BOVIN Computationally mapped isoform of Neuromedin-U receptor 2 OS=Bos taurus OX=9913 GN=NMUR2 PE=2 SV=2 CANONICAL=Q58CW4-1" }, "locus": { "chromosome": "7", "start_pos": 63653756, "end_pos": 63636926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014782.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014782.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014782.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014782.5" } ] } }, { "isoform_ac": "Q58CW4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW4/entry#Q58CW4-1", "sequence": { "sequence": "MEKHENVSWMYQQELKDPFKKYLNNTDDYLALLCGPRRSHLFLPVTAVYALIFVVGVVGNLLVCLVILRHQTMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAVLHPFRAKLKSTRGRALRILGIVWGLSVLFSLPNTSIHGIKLHYFPNGSIIPGSATCTVIKPMWIYNFIIQVTSLLFYILPMTVISVLYYLMGLKLKKDQHLEADKVTANIQRPSRKSVTKMLFVLVLVFAICWAPFHIDRLFFSFVEEWTEPLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSHRFQAAFRTVIPPSCQQQHSHNHSPGPSMQRNIFLTECHLVELTEDVAPQFPRQLSVLSSQLPTALCTGQVPRKELAKS", "length": 407, "header": "sp|Q58CW4-1|NMUR2_BOVIN Isoform 1 of Neuromedin-U receptor 2 OS=Bos taurus OX=9913 GN=NMUR2 PE=2 SV=1 CANONICAL=Q58CW4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 191, "start_aa": "Asn", "end_pos": 191, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn191", "evidence": [ { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 24, "start_aa": "Asn", "end_pos": 24, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn24", "evidence": [ { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 6, "start_aa": "Asn", "end_pos": 6, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn6", "evidence": [ { "id": "Q58CW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507439", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507439", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "arachidonate secretion", "id": "GO:0050482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050482", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "neuropeptide receptor activity", "id": "GO:0008188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008188", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "neuromedin U receptor activity", "id": "GO:0001607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001607", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "intracellularly calcium-gated chloride channel activity", "id": "GO:0005229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005229", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" }, { "name": "neuromedin U binding", "id": "GO:0042924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042924", "evidence": [ { "database": "UniProtKB", "id": "Q58CW4", "url": "https://www.uniprot.org/uniprotkb/Q58CW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CW4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 407, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CW4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CW4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 6, 24, 191 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 191, "end_pos": 193 }, { "start_pos": 24, "end_pos": 26 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PF3-1", "uniprot_ac": "Q32PF3", "uniprot_id": "PCNP_BOVIN", "mass": { "chemical_mass": 18988.0, "monoisotopic_mass": 18988.0 }, "refseq": { "ac": "NP_001033294", "name": "PEST proteolytic signal-containing nuclear protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033294" }, "gene_names": [ { "name": "PCNP", "type": "recommended", "evidence": [ { "id": "Q32PF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ] }, { "name": "PCNP", "type": "synonym", "evidence": [ { "id": "NP_001033294", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033294" } ] } ], "protein_names": [ { "name": "PEST proteolytic signal-containing nuclear protein", "type": "recommended", "evidence": [ { "id": "Q32PF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#names_and_taxonomy" } ] }, { "name": "PCNP", "type": "synonym", "evidence": [ { "id": "Q32PF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#names_and_taxonomy" } ] }, { "name": "PEST proteolytic signal-containing nuclear protein", "type": "synonym", "evidence": [ { "id": "NP_001033294", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033294" } ] }, { "name": "PEST-containing nuclear protein", "type": "synonym", "evidence": [ { "id": "NP_001033294", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033294" }, { "id": "Q32PF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in cell cycle regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIL1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIL1#function" }, { "database": "UniProtKB", "id": "ARBA00002646", "url": "https://www.uniprot.org/uniprotkb/ARBA00002646#function" }, { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3#function" }, { "database": "UniProtKB", "id": "A0ABI0NM21", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM21#function" }, { "database": "UniProtKB", "id": "A0ABI0NRL0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRL0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCNP", "url": "https://www.uniprot.org/uniprotkb/Q32PF3", "locus": { "chromosome": "1", "start_pos": 46016856, "end_pos": 46001766, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015069", "url": "https://www.ensembl.org/id/ENSBTAG00000015069" } ] } } ], "crossref": [ { "id": "Q32PF3", "url": "https://alphafold.ebi.ac.uk/entry/Q32PF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015069", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015069", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615197", "url": "https://www.ncbi.nlm.nih.gov/gene/615197", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615197", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615197", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKDMMAD", "url": "https://omabrowser.org/oma/group/EKDMMAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIL1", "url": "https://www.orthodb.org/?gene=A0A452DIL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32PF3", "url": "https://www.orthodb.org/?gene=Q32PF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16523:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16523:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15473", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15473", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033294", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIL1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM21", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM21-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRL0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRL0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGENSSRSAEKRSAEDETADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKEPVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 178, "header": "sp|Q32PF3-1|PCNP_BOVIN Isoform 1 of PEST proteolytic signal-containing nuclear protein OS=Bos taurus OX=9913 GN=PCNP PE=2 SV=1 CANONICAL=Q32PF3-1" }, "isoforms": [ { "isoform_ac": "A0A452DIL1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#A0A452DIL1-1", "sequence": { "sequence": "VVSTSPGPEEEAEKPVKTKTVSSSNGGENSSRSAEKRSAEDETADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKEPVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 163, "header": "tr|A0A452DIL1-1|PCNP_BOVIN Computationally mapped isoform of PEST proteolytic signal-containing nuclear protein OS=Bos taurus OX=9913 GN=PCNP PE=2 SV=2 CANONICAL=Q32PF3-1" }, "locus": { "chromosome": "1", "start_pos": 46015135, "end_pos": 46007090, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017901.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017901.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017901.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017901.6" } ] } }, { "isoform_ac": "A0ABI0NM21-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#A0ABI0NM21-1", "sequence": { "sequence": "MLFEVAAPINLLSKNSSSCNGGENSSRSAEKRSAEDETADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKEPVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 158, "header": "tr|A0ABI0NM21-1|A0ABI0NM21_BOVIN Computationally mapped isoform of PEST proteolytic signal-containing nuclear protein OS=Bos taurus OX=9913 GN=PCNP PE=1 SV=1 CANONICAL=Q32PF3-1" }, "locus": { "chromosome": "1", "start_pos": 46015135, "end_pos": 46007030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106319.1" } ] } }, { "isoform_ac": "A0ABI0NRL0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#A0ABI0NRL0-1", "sequence": { "sequence": "MVAGRGRDVLGVAAGEAAAGKMADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGENSSRSAEKRSAEDETADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKEPVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 199, "header": "tr|A0ABI0NRL0-1|A0ABI0NRL0_BOVIN Computationally mapped isoform of PEST proteolytic signal-containing nuclear protein OS=Bos taurus OX=9913 GN=PCNP PE=1 SV=1 CANONICAL=Q32PF3-1" }, "locus": { "chromosome": "1", "start_pos": 46015135, "end_pos": 46001965, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143378.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143378.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106315.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106315.1" } ] } }, { "isoform_ac": "Q32PF3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF3/entry#Q32PF3-1", "sequence": { "sequence": "MADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGENSSRSAEKRSAEDETADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKEPVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 178, "header": "sp|Q32PF3-1|PCNP_BOVIN Isoform 1 of PEST proteolytic signal-containing nuclear protein OS=Bos taurus OX=9913 GN=PCNP PE=2 SV=1 CANONICAL=Q32PF3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 119, "end_pos": 119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Ser119" }, { "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Thr139" }, { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Ser147" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Ser53" }, { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Ser77" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "site_lbl": "Ser87" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615197", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615197", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1GJK2-1", "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "PCNP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSTKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 178 }, "evidence": [ { "id": "Q32PF3", "url": "https://omabrowser.org/oma/group/Q32PF3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6P8I4-1", "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "Pcnp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEDEAADLPTKPTKMSKFGFAIGSQTARKASAISIRLGASKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 178 }, "evidence": [ { "id": "Q32PF3", "url": "https://omabrowser.org/oma/group/Q32PF3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TP40-1", "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "Pcnp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGASCTATQSQFLLYTLTSSEETVGSVGDSCRGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEDEAADLPTKPTKMSKFGFAIGSQTARKASAISIRLGASKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 189 }, "evidence": [ { "id": "Q32PF3", "url": "https://omabrowser.org/oma/group/Q32PF3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WW12-1", "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "PCNP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN", "length": 178 }, "evidence": [ { "id": "Q32PF3", "url": "https://omabrowser.org/oma/group/Q32PF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q32PF3", "url": "https://www.uniprot.org/uniprotkb/Q32PF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PF3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PF3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PF3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 53, 77, 87, 119, 139, 147 ], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0D5-1", "uniprot_ac": "Q3T0D5", "uniprot_id": "RL30_BOVIN", "mass": { "chemical_mass": 12784.0, "monoisotopic_mass": 12784.0 }, "refseq": { "ac": "NP_001029606", "name": "large ribosomal subunit protein eL30", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029606" }, "gene_names": [ { "name": "RPL30", "type": "recommended", "evidence": [ { "id": "Q3T0D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ] }, { "name": "RPL30", "type": "synonym", "evidence": [ { "id": "NP_001029606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029606" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL30", "type": "recommended", "evidence": [ { "id": "Q3T0D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L30", "type": "synonym", "evidence": [ { "id": "NP_001029606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029606" }, { "id": "Q3T0D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL30", "type": "synonym", "evidence": [ { "id": "NP_001029606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029606" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5#function" }, { "database": "UniProtKB", "id": "P62888", "url": "https://www.uniprot.org/uniprotkb/P62888#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL30", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5", "locus": { "chromosome": "14", "start_pos": 66179592, "end_pos": 66176274, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016278", "url": "https://www.ensembl.org/id/ENSBTAG00000016278" } ] } } ], "crossref": [ { "id": "Q3T0D5", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513031", "url": "https://www.ncbi.nlm.nih.gov/gene/513031", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "845212", "url": "https://www.iedb.org/epitope/845212", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR000231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513031", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513031", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFQGGNN", "url": "https://omabrowser.org/oma/group/YFQGGNN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIP9", "url": "https://www.orthodb.org/?gene=A0A452DIP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T0D5", "url": "https://www.orthodb.org/?gene=Q3T0D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11449", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11449", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q3T0D5", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q3T0D5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029606", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIP9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0D5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115, "header": "sp|Q3T0D5-1|RL30_BOVIN Isoform 1 of Large ribosomal subunit protein eL30 OS=Bos taurus OX=9913 GN=RPL30 PE=3 SV=3 CANONICAL=Q3T0D5-1" }, "isoforms": [ { "isoform_ac": "A0A452DIP9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5/entry#A0A452DIP9-1", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSKTTRPVSGKYCLFFWLNSTCRIDSLLWRSQPGW", "length": 135, "header": "tr|A0A452DIP9-1|RL30_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL30 OS=Bos taurus OX=9913 GN=RPL30 PE=3 SV=1 CANONICAL=Q3T0D5-1" }, "locus": { "chromosome": "14", "start_pos": 66179544, "end_pos": 66176450, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021651.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021651.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021651.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021651.6" } ] } }, { "isoform_ac": "Q3T0D5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5/entry#Q3T0D5-1", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115, "header": "sp|Q3T0D5-1|RL30_BOVIN Isoform 1 of Large ribosomal subunit protein eL30 OS=Bos taurus OX=9913 GN=RPL30 PE=3 SV=3 CANONICAL=Q3T0D5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "site_lbl": "Ser10" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "site_lbl": "Ser16" } ], "glycation": [], "keywords": [], "publication": [ { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "845212", "url": "https://www.iedb.org/epitope/845212" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] } ], "pathway": [ { "id": "bta:513031", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513031", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TXJ8-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "RPL30", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P14120-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "RPL30", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAPVKSQESINQKLALVIKSGKYTLGYKSTVKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSILEAGDSDILTTLA", "length": 105 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P62888-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "RPL30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62889-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "Rpl30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62890-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "Rpl30", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK", "length": 115 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P67883-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "RPL30", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTSEK", "length": 115 }, "evidence": [ { "id": "Q3T0D5", "url": "https://omabrowser.org/oma/group/Q3T0D5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D5", "url": "https://www.uniprot.org/uniprotkb/Q3T0D5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0D5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 115, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0D5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0D5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 10, 16 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0L7-1", "uniprot_ac": "Q3T0L7", "uniprot_id": "RL28_BOVIN", "mass": { "chemical_mass": 15692.0, "monoisotopic_mass": 15692.0 }, "refseq": { "ac": "NP_001030580", "name": "large ribosomal subunit protein eL28", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030580" }, "gene_names": [ { "name": "RPL28", "type": "recommended", "evidence": [ { "id": "Q3T0L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ] }, { "name": "RPL28", "type": "synonym", "evidence": [ { "id": "NP_001030580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030580" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL28", "type": "recommended", "evidence": [ { "id": "Q3T0L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L28", "type": "synonym", "evidence": [ { "id": "NP_001030580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030580" }, { "id": "Q3T0L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL28", "type": "synonym", "evidence": [ { "id": "NP_001030580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030580" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7#function" }, { "database": "UniProtKB", "id": "P46779", "url": "https://www.uniprot.org/uniprotkb/P46779#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL28", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7", "locus": { "chromosome": "18", "start_pos": 62099121, "end_pos": 62102117, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023343", "url": "https://www.ensembl.org/id/ENSBTAG00000023343" } ] } } ], "crossref": [ { "id": "Q3T0L7", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023343", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023343", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618702", "url": "https://www.ncbi.nlm.nih.gov/gene/618702", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618702", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618702", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKYGQRP", "url": "https://omabrowser.org/oma/group/GKYGQRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ34", "url": "https://www.orthodb.org/?gene=A0A452DJ34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T0L7", "url": "https://www.orthodb.org/?gene=Q3T0L7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10544", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10544", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030580", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ34", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ34-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0L7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKPSRPTKSS", "length": 137, "header": "sp|Q3T0L7-1|RL28_BOVIN Isoform 1 of Large ribosomal subunit protein eL28 OS=Bos taurus OX=9913 GN=RPL28 PE=2 SV=3 CANONICAL=Q3T0L7-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ34-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7/entry#A0A452DJ34-1", "sequence": { "sequence": "MRVDIKGVAPPLACLFPSPAAAPRGGEWRLLPLPACLSLAPAACVCAPAWSLSPRPSRSWLLFGAAALVAAMSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKPSRPTKSS", "length": 208, "header": "tr|A0A452DJ34-1|RL28_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL28 OS=Bos taurus OX=9913 GN=RPL28 PE=2 SV=1 CANONICAL=Q3T0L7-1" }, "locus": { "chromosome": "18", "start_pos": 62101918, "end_pos": 62099174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031754.3", "url": "https://www.ensembl.org/id/ENSBTAT00000031754.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031700.2", "url": "https://www.ensembl.org/id/ENSBTAP00000031700.2" } ] } }, { "isoform_ac": "A0AAA9SLG5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7/entry#A0AAA9SLG5-1", "sequence": { "sequence": "MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMVSRAGPRRWAGARGNEGWSSPDWSRTCALGTQGWGHKLPGEVT", "length": 151, "header": "tr|A0AAA9SLG5-1|A0AAA9SLG5_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL28 OS=Bos taurus OX=9913 GN=RPL28 PE=1 SV=1 CANONICAL=Q3T0L7-1" }, "locus": { "chromosome": "18", "start_pos": 62101478, "end_pos": 62099281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103258.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103258.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083492.1" } ] } }, { "isoform_ac": "Q3T0L7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7/entry#Q3T0L7-1", "sequence": { "sequence": "MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKPSRPTKSS", "length": 137, "header": "sp|Q3T0L7-1|RL28_BOVIN Isoform 1 of Large ribosomal subunit protein eL28 OS=Bos taurus OX=9913 GN=RPL28 PE=2 SV=3 CANONICAL=Q3T0L7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 115, "end_pos": 115, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "site_lbl": "Ser115" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618702", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618702", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "O82204-1", "protein_name": "Large ribosomal subunit protein eL28z", "gene_name": "RPL28A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATVPGQLIWEIVKNNNCFLVKQFGRGNSKVQFSKETNNLTNVHSYKHSGLANKKTVTIQAADKDQAVVLATTKTKKQNKPKLSVNKSILKKEFPRMSKAVANQVVDNYYRPDLKKAALARLSAISKGLRVAKSGAKQRNRQA", "length": 143 }, "evidence": [ { "id": "Q3T0L7", "url": "https://omabrowser.org/oma/group/Q3T0L7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9GS21-1", "protein_name": "Large ribosomal subunit protein eL28", "gene_name": "rpl28", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQDLVWSIIKKNNAFLKSSHGLTLSAEPGNLRNKNSLKYSGLARRTTIDVAAVNGKVVVSSKIVKKAAFPAQSKKTTTFSTVNTRKTARFVKTLATQYAPELRAAALGRLHRVQSALRSAKKAAARKAKKN", "length": 132 }, "evidence": [ { "id": "Q3T0L7", "url": "https://omabrowser.org/oma/group/Q3T0L7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VZS5-1", "protein_name": "Large ribosomal subunit protein eL28", "gene_name": "RpL28", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATSSHLNWLIIRNNNAFLLKKRDVKKPFSTEPNNLASVSSYRYSGIVHKKTLGVVPAADKKGFTAVLKKGKYAQRPAKNTVRVDFKAGPRRSLKKLKNLLIGSKYRKDLTQAALRRASAVLRSQKPAPVKGKKAEFAKGKKPE", "length": 144 }, "evidence": [ { "id": "Q3T0L7", "url": "https://omabrowser.org/oma/group/Q3T0L7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3T0L7", "url": "https://www.uniprot.org/uniprotkb/Q3T0L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0L7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 137, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0L7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0L7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 115 ], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC22-1", "uniprot_ac": "Q3ZC22", "uniprot_id": "HSBP1_BOVIN", "mass": { "chemical_mass": 8530.0, "monoisotopic_mass": 8530.0 }, "refseq": { "ac": "NP_001106787", "name": "heat shock factor-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787" }, "gene_names": [ { "name": "HSBP1", "type": "recommended", "evidence": [ { "id": "Q3ZC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ] }, { "name": "HSBP1", "type": "synonym", "evidence": [ { "id": "NP_001106787", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787" } ] } ], "protein_names": [ { "name": "Heat shock factor-binding protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22/entry#names_and_taxonomy" } ] }, { "name": "heat shock factor-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001106787", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787" } ] } ], "function": [ { "annotation": "Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DJ57", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ57#function" }, { "database": "UniProtKB", "id": "ARBA00037689", "url": "https://www.uniprot.org/uniprotkb/ARBA00037689#function" }, { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22#function" } ] }, { "annotation": "The effect of H2H2 haplotype combination on thermo tolerance traits major due to the single nucleotide pomylorphism of g.651C>G of HSBP1.", "evidence": [ { "database": "RefSeq", "id": "NP_001106787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787" }, { "database": "PubMed", "id": "23572288", "url": "https://glygen.org/publication/PubMed/23572288" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22", "locus": { "chromosome": "18", "start_pos": 25314722, "end_pos": 25315535, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024889", "url": "https://www.ensembl.org/id/ENSBTAG00000024889" } ] } } ], "crossref": [ { "id": "Q3ZC22", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024889", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024889", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000053436", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053436", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767979", "url": "https://www.ncbi.nlm.nih.gov/gene/767979", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767979", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767979", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MERANMD", "url": "https://omabrowser.org/oma/group/MERANMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "TMSSWIT", "url": "https://omabrowser.org/oma/group/TMSSWIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ57", "url": "https://www.orthodb.org/?gene=A0A452DJ57", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC22", "url": "https://www.orthodb.org/?gene=Q3ZC22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19424", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19424", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19424:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19424:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3371568", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371568", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371571", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ57", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ57-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC22-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELDSENKIPATQKS", "length": 76, "header": "sp|Q3ZC22-1|HSBP1_BOVIN Isoform 1 of Heat shock factor-binding protein 1 OS=Bos taurus OX=9913 GN=HSBP1 PE=3 SV=1 CANONICAL=Q3ZC22-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ57-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22/entry#A0A452DJ57-1", "sequence": { "sequence": "MAADSLRQHHQAGNWGDDPKTMQDLTSVMQALLQQIQDKFQTISDQTIGRTDDTMSSWITGRTDDMRSRIGDLDKNTIDLMTQAGVKELDGENKTPAPQRSWSLLMRTRLCSILFMSQEKMEDGWLFATNYYV", "length": 133, "header": "tr|A0A452DJ57-1|HSBP1_BOVIN Computationally mapped isoform of Heat shock factor-binding protein 1 OS=Bos taurus OX=9913 GN=HSBP1 PE=3 SV=1 CANONICAL=Q3ZC22-1" }, "locus": { "chromosome": "18", "start_pos": 25315535, "end_pos": 25314725, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034656.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034656.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034543.3", "url": "https://www.ensembl.org/id/ENSBTAP00000034543.3" } ] } }, { "isoform_ac": "Q3ZC22-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22/entry#Q3ZC22-1", "sequence": { "sequence": "MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELDSENKIPATQKS", "length": 76, "header": "sp|Q3ZC22-1|HSBP1_BOVIN Isoform 1 of Heat shock factor-binding protein 1 OS=Bos taurus OX=9913 GN=HSBP1 PE=3 SV=1 CANONICAL=Q3ZC22-1" }, "locus": { "chromosome": "18", "start_pos": 10163718, "end_pos": 10162416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145517.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145517.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105048.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genetic variations of HSBP1 gene and its effect on thermal performance traits in Chinese Holstein cattle.", "journal": "Molecular biology reports", "date": "2013-06", "authors": "Wang YanJiu, Huang Jingmin, Xia Peng, He JianBin, Wang Changfa, Ju Zhihua, Li Jianbin, Li Rongling, Zhong Jifeng, Li Qiuling", "evidence": [ { "database": "RefSeq", "id": "NP_001106787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106787" } ], "reference": [ { "type": "PubMed", "id": "23572288", "url": "https://glygen.org/publication/PubMed/23572288" } ] } ], "pathway": [ { "id": "bta:767979", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767979", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371568", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371568", "resource": "Reactome", "description": "Attenuation phase" }, { "id": "R-BTA-3371571", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371571", "resource": "Reactome", "description": "HSF1-dependent transactivation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PAM4-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "HSBP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAETDPKTVQDLTAVVQTLLQQMQDKFQTMSDQIIGRIDDMSCRIDDLEKNIADLMTQAGVEELEGENKAPATTNKS", "length": 77 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287BMT8-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "HSBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELEGDNKIPATQKS", "length": 76 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75506-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "HSBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELESENKIPATQKS", "length": 76 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8GW48-1", "protein_name": "Heat shock factor-binding protein", "gene_name": "HSBP", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGHDSEDTKQSTADMTAFVQNLLQQMQTRFQTMSDSIITKIDDMGGRINELEQSINDLRAEMGVEGTPPPASKSGDEPKTPASSS", "length": 86 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8K3X8-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "Hsbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAETDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELDAENKIPTAQKS", "length": 76 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQZ1-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "Hsbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELDPENKIPTAQKS", "length": 76 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VK90-1", "protein_name": "Heat shock factor-binding protein 1", "gene_name": "BcDNA:RE36920", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTDLRNEMDSDLDQNYSLNSNADPKNMQELTIYVQNLLQNVQDKFQTMSDQIITRIDDMGNRIDDLEKSIADLMNQAGIEGQGPEK", "length": 86 }, "evidence": [ { "id": "Q3ZC22", "url": "https://omabrowser.org/oma/group/Q3ZC22/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "axonal transport of mitochondrion", "id": "GO:0019896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019896", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" }, { "name": "cellular heat acclimation", "id": "GO:0070370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070370", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC22", "url": "https://www.uniprot.org/uniprotkb/Q3ZC22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 76, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC22" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZE4-1", "uniprot_ac": "Q3SZE4", "uniprot_id": "ASB11_BOVIN", "mass": { "chemical_mass": 35316.0, "monoisotopic_mass": 35316.0 }, "refseq": { "ac": "NP_001029585", "name": "ankyrin repeat and SOCS box protein 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585" }, "gene_names": [ { "name": "ASB11", "type": "recommended", "evidence": [ { "id": "Q3SZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ] }, { "name": "ASB11", "type": "synonym", "evidence": [ { "id": "NP_001029585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 11", "type": "recommended", "evidence": [ { "id": "Q3SZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4/entry#names_and_taxonomy" } ] }, { "name": "ASB-11", "type": "synonym", "evidence": [ { "id": "NP_001029585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585" }, { "id": "Q3SZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase", "type": "synonym", "evidence": [ { "id": "NP_001029585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585" } ] }, { "name": "ankyrin repeat and SOCS box protein 11", "type": "synonym", "evidence": [ { "id": "NP_001029585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585" } ] } ], "function": [ { "annotation": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1. The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4#function" }, { "database": "UniProtKB", "id": "Q8WXH4", "url": "https://www.uniprot.org/uniprotkb/Q8WXH4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB11", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4", "locus": { "chromosome": "X", "start_pos": 128207822, "end_pos": 128177632, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001514", "url": "https://www.ensembl.org/id/ENSBTAG00000001514" } ] } } ], "crossref": [ { "id": "Q3SZE4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001514", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001514", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511852", "url": "https://www.ncbi.nlm.nih.gov/gene/511852", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511852", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511852", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GRACHQV", "url": "https://omabrowser.org/oma/group/GRACHQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ71", "url": "https://www.orthodb.org/?gene=A0A452DJ71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZE4", "url": "https://www.orthodb.org/?gene=Q3SZE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029585", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ71", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ71-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUT7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUT7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZE4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDGSVSYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNHGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ", "length": 323, "header": "sp|Q3SZE4-1|ASB11_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 11 OS=Bos taurus OX=9913 GN=ASB11 PE=2 SV=1 CANONICAL=Q3SZE4-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ71-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4/entry#A0A452DJ71-1", "sequence": { "sequence": "MKEETSSFCICFSQLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNHGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ", "length": 312, "header": "tr|A0A452DJ71-1|ASB11_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 11 OS=Bos taurus OX=9913 GN=ASB11 PE=2 SV=1 CANONICAL=Q3SZE4-1" }, "locus": { "chromosome": "X", "start_pos": 128207363, "end_pos": 128177667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038842.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038842.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038650.4", "url": "https://www.ensembl.org/id/ENSBTAP00000038650.4" } ] } }, { "isoform_ac": "A0ABI0NUT7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4/entry#A0ABI0NUT7-1", "sequence": { "sequence": "MLQLTGENEKNLEVSESGRSLGVWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNHGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ", "length": 302, "header": "tr|A0ABI0NUT7-1|A0ABI0NUT7_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 11 OS=Bos taurus OX=9913 GN=ASB11 PE=3 SV=1 CANONICAL=Q3SZE4-1" }, "locus": { "chromosome": "X", "start_pos": 128207363, "end_pos": 128179991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151035.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151035.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105035.1" } ] } }, { "isoform_ac": "Q3SZE4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4/entry#Q3SZE4-1", "sequence": { "sequence": "MEDGSVSYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNHGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ", "length": 323, "header": "sp|Q3SZE4-1|ASB11_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 11 OS=Bos taurus OX=9913 GN=ASB11 PE=2 SV=1 CANONICAL=Q3SZE4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511852", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511852", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZSR2-1", "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "Asb11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYDANYNSVKIFSRRNLCREEAKMEDGPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDHGRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHEGPPALSQLCRLCVRKCLGRTCHQAIYALDCLDQDVCSSTNHRAGISQGHQKHGI", "length": 360 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XB69-1", "protein_name": "Ankyrin repeat and SOCS box containing 11", "gene_name": "ASB11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGSSILQASTNIYFAIFALFCFKLLIKISLALLTHFYIVKGNRKEAARIAEEIYGIVPGSWADRSPLHDAAFQGRLLSLKTLIAQGFNVNLVTTDRVSALHEACLGGHVACAKLLLENGAHVNAVTIDGITPLFNACCSGSVACVNMLLEFGAKPQVGNHLASPIHEAVKRGHRECMEVLLAHGVDIDQEDLQYGTLLYVACMYQRTDCVKKLLELGANVNAGKRLDTPLHAAARKSSAEIVILLADYGANLKCRNAEFKCALDLAIPNSKVEQALLLREGKGLFCLFPFTFSSLSFPLCRFKVEQYLFILPETFFLIDLIFSVSSLLILSLYHATQK", "length": 339 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7GKM7-1", "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "Asb11", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYDANYNSVKICSPKNLCREAAKMEDGPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEVPQLGTPLYVACTYERVDCVKKLLELGASVDHGRWLDTPLHAAARQSNVEVINLLTEYGASLKLRNSEGKSALDLAAPKSSVEQALLLHEGPPALSQLCRLCVRKCLGRACHQAICQLGLPEPLEKFLLYQ", "length": 347 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LHT1-1", "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "ASB11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLQLMGENEKNLEVLGNTRRPGVWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYVACTYQRVDCVKKLLELGANVDHGQWLDSPLHAAARQNSVEIIHLLIDFGANIKGKNAQGKIALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRTCHQTIQKLYLPEPLERFLLYQ", "length": 302 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8WXH4-1", "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "ASB11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ", "length": 323 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQ31-1", "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "Asb11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDAPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLHEGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ", "length": 323 }, "evidence": [ { "id": "Q3SZE4", "url": "https://omabrowser.org/oma/group/Q3SZE4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE4", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZE4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE4" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 273, "end_pos": 323, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCH5-1", "uniprot_ac": "Q3ZCH5", "uniprot_id": "ZA2G_BOVIN", "mass": { "chemical_mass": 33852.0, "monoisotopic_mass": 33852.0 }, "refseq": { "ac": "NP_001029503", "name": "zinc-alpha-2-glycoprotein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" }, "gene_names": [ { "name": "AZGP1", "type": "recommended", "evidence": [ { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ] }, { "name": "AZGP1", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ] }, { "name": "ZAG", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ] } ], "protein_names": [ { "name": "Zinc-alpha-2-glycoprotein", "type": "recommended", "evidence": [ { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#names_and_taxonomy" } ] }, { "name": "Zn-alpha-2-GP", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" }, { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#names_and_taxonomy" } ] }, { "name": "Zn-alpha-2-glycoprotein", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" }, { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#names_and_taxonomy" } ] }, { "name": "zinc-alpha-2-glycoprotein precursor", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ] }, { "name": "zinc-alpha-2-glycoprotein", "type": "synonym", "evidence": [ { "id": "NP_001029503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ] } ], "function": [ { "annotation": "Association analysis of different genotypes with some of the growth and development traits", "evidence": [ { "database": "RefSeq", "id": "NP_001029503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" }, { "database": "PubMed", "id": "19073549", "url": "https://glygen.org/publication/PubMed/19073549" } ] }, { "annotation": "Polymorphisms in the AZGP1 gene were associated with growth traits.", "evidence": [ { "database": "RefSeq", "id": "NP_001029503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" }, { "database": "PubMed", "id": "23073769", "url": "https://glygen.org/publication/PubMed/23073769" } ] }, { "annotation": "Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AZGP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5", "locus": { "chromosome": "25", "start_pos": 36445778, "end_pos": 36450266, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026236", "url": "https://www.ensembl.org/id/ENSBTAG00000026236" } ] } } ], "crossref": [ { "id": "Q3ZCH5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026236", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026236", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508800", "url": "https://www.ncbi.nlm.nih.gov/gene/508800", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508800", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508800", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "APYSCYV", "url": "https://omabrowser.org/oma/group/APYSCYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DK44", "url": "https://www.orthodb.org/?gene=A0A452DK44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCH5", "url": "https://www.orthodb.org/?gene=Q3ZCH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675:SF289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675:SF289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5223345", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DK44", "url": "https://www.uniprot.org/uniprotkb/A0A452DK44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DK44-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DK44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U249", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U249-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U249-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCH5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPVLLALLLLLGPAVSEETQAGNYSLSFLYTGLSKPREGFPSFQAVAYLNDQPFFHYNSEGRRAEPLAPWSQVEGMEDWEKESALQRAREDIFMETLSDIMDYYKDREGSHTFQGAFGCELRNNESSGAFWGYAYDGQDFIKFDKEIPAWVPLDPAAQNTKRKWEAEAVYVQRAKAYLEEECPGMLRRYLPYSRTHLDRQESPSVSVTGHAAPGHKRTLKCLAYDFYPRSIGLHWTRAGDAQEAESGGDVLPSGNGTYQSWVVVGVPPEDQAPYSCHVEHRSLTRPLTVPWDPRQQAE", "length": 299, "header": "sp|Q3ZCH5-1|ZA2G_BOVIN Isoform 1 of Zinc-alpha-2-glycoprotein OS=Bos taurus OX=9913 GN=AZGP1 PE=2 SV=1 CANONICAL=Q3ZCH5-1" }, "isoforms": [ { "isoform_ac": "A0A452DK44-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#A0A452DK44-1", "sequence": { "sequence": "MVPVLLALLLLLGPAVSEETQAGNYSLSFLYTGLSKPREGFPSFQAVAYLNDQPFFHYNSEGRRAEPLAPWSQVEGMEDWEKESALQRAREDIFMETLSDIMDYYKDREGSHTFQGAFGCELRNNESSGAFWGYAYDGQDFIKFDKEIPAWVPLDPAAQNTKRKWEAEAVYVQRAKAYLEEECPGMLRRYLPYSRTHLDRQESPSVSVTGHAAPGHKRTLKCLAYDFYPRSIGLHWTRAGDAQEAESGGDVLPSGNGTYQSWVVVGVPSEDQAPYSCHVEHRSLTRPLTVPWDPRQQAE", "length": 299, "header": "tr|A0A452DK44-1|ZA2G_BOVIN Computationally mapped isoform of Zinc-alpha-2-glycoprotein OS=Bos taurus OX=9913 GN=AZGP1 PE=2 SV=1 CANONICAL=Q3ZCH5-1" }, "locus": { "chromosome": "25", "start_pos": 36450200, "end_pos": 36446055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037204.3", "url": "https://www.ensembl.org/id/ENSBTAT00000037204.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037042.3", "url": "https://www.ensembl.org/id/ENSBTAP00000037042.3" } ] } }, { "isoform_ac": "A0AAA9U249-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#A0AAA9U249-1", "sequence": { "sequence": "PQDRRLPLLLGEAPASFSSFTGNYSLSFLYTGLSKPREGFPSFQAVAYLNDQPFFHYNSEGRRAEPLAPWSQVEGMEDWEKESALQRAREDIFMETLSDIMDYYKDREGSHTFQGAFGCELRNNESSGAFWGYAYDGQDFIKFDKEIPAWVPLDPAAQNTKRKWEAEAVYVQRAKAYLEEECPGMLRRYLPYSRTHLDRQESPSVSVTGHAAPGHKRTLKCLAYDFYPRSIGLHWTRAGDAQEAESGGDVLPSGNGTYQSWVVVGVPSEDQAPYSCHVEHRSLTRPLTVPWDPRQQAE", "length": 298, "header": "tr|A0AAA9U249-1|A0AAA9U249_BOVIN Computationally mapped isoform of Zinc-alpha-2-glycoprotein OS=Bos taurus OX=9913 GN=AZGP1 PE=1 SV=1 CANONICAL=Q3ZCH5-1" }, "locus": { "chromosome": "25", "start_pos": 36448408, "end_pos": 36446055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103459.1" } ] } }, { "isoform_ac": "Q3ZCH5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5/entry#Q3ZCH5-1", "sequence": { "sequence": "MVPVLLALLLLLGPAVSEETQAGNYSLSFLYTGLSKPREGFPSFQAVAYLNDQPFFHYNSEGRRAEPLAPWSQVEGMEDWEKESALQRAREDIFMETLSDIMDYYKDREGSHTFQGAFGCELRNNESSGAFWGYAYDGQDFIKFDKEIPAWVPLDPAAQNTKRKWEAEAVYVQRAKAYLEEECPGMLRRYLPYSRTHLDRQESPSVSVTGHAAPGHKRTLKCLAYDFYPRSIGLHWTRAGDAQEAESGGDVLPSGNGTYQSWVVVGVPPEDQAPYSCHVEHRSLTRPLTVPWDPRQQAE", "length": 299, "header": "sp|Q3ZCH5-1|ZA2G_BOVIN Isoform 1 of Zinc-alpha-2-glycoprotein OS=Bos taurus OX=9913 GN=AZGP1 PE=2 SV=1 CANONICAL=Q3ZCH5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 125, "start_aa": "Asn", "end_pos": 125, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn125", "evidence": [ { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 24, "start_aa": "Asn", "end_pos": 24, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn24", "evidence": [ { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 256, "start_aa": "Asn", "end_pos": 256, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn256", "evidence": [ { "id": "Q3ZCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "[Polymorphisms of ZAG gene with growth traits in Jiaxian red cattle].", "journal": "Yi chuan = Hereditas", "date": "2008-11", "authors": "Guo Yi-Kun, Chen Hong, Zhang Bao, Pan Chuan-Ying, Zhang Liang-Zhi, Zhao Miao, Zhang Cun-Fang, Lan Xian-Yong, Wang Ju-Qiang", "evidence": [ { "database": "RefSeq", "id": "NP_001029503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ], "reference": [ { "type": "PubMed", "id": "19073549", "url": "https://glygen.org/publication/PubMed/19073549" } ] }, { "title": "Genotype and haplotype analysis of the AZGP1 gene in cattle.", "journal": "Molecular biology reports", "date": "2012-12", "authors": "Zhang Bao, Guo Yi Kun, Li Shengbin, Zhang Liang Zhi, Lan Xian Yong, Hu Shen Rong, Chen Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001029503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029503" } ], "reference": [ { "type": "PubMed", "id": "23073769", "url": "https://glygen.org/publication/PubMed/23073769" } ] } ], "pathway": [ { "id": "bta:508800", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508800", "resource": "KEGG Pathway" }, { "id": "R-BTA-5223345", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "resource": "Reactome", "description": "Miscellaneous transport and binding events" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I5E5-1", "protein_name": "Zinc-alpha-2-glycoprotein", "gene_name": "Azgp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVPVLLSLPLLLGPAVLQETGPYSLVFLYTGLSRPSKGIPRFQATAFLNDQAFFHYNSNSGKVEPVGPWSQIEGMEDWEKESQLQKAREEIFLVTLKDIMDYYKDSAGSHTFQGMFGCELLNNRSSGAFWRYAYDGQDFIEFNKEIPAWIPLDPAAVNTKQKWEAEKAYTQRAKAYLEEECPTMLKRYLNYSRSHLDQKDPPTVTITSHTAPGRNRIFKCLAYDFYPQGISLHWNQAGKMLTSKSGGVFPNGNGTYLSWVEVEVPAQDRDPYFCHIEHSGLSQSLSVQWDETRKAKAESNMATQPQ", "length": 306 }, "evidence": [ { "id": "Q3ZCH5", "url": "https://omabrowser.org/oma/group/Q3ZCH5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P25311-1", "protein_name": "Zinc-alpha-2-glycoprotein", "gene_name": "AZGP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS", "length": 298 }, "evidence": [ { "id": "Q3ZCH5", "url": "https://omabrowser.org/oma/group/Q3ZCH5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64726-1", "protein_name": "Zinc-alpha-2-glycoprotein", "gene_name": "Azgp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPVLLSLPLLLGPAVFQETGSYYLTFLYTGLSRPSKGFPRFQATAFLNDQAFFHYNSNSGKAEPVGPWSQVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYKDTTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPEMLKRYLNYSRSHLDRIDPPTVTITSRVIPGGNRIFKCLAYGFYPQRISLHWNKANKKLAFEPERGVFPNGNGTYLSWAEVEVSPQDIDPFFCLIDHRGFSQSLSVQWDRTRKVKDENNVVAQPQ", "length": 307 }, "evidence": [ { "id": "Q3ZCH5", "url": "https://omabrowser.org/oma/group/Q3ZCH5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib", "id": "GO:0002476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002476", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "id": "GO:0002486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002486", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 299, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 24, 125, 256 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 24, "end_pos": 26 }, { "start_pos": 256, "end_pos": 258 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CR1-1", "uniprot_ac": "Q58CR1", "uniprot_id": "MTFR2_BOVIN", "mass": { "chemical_mass": 40979.0, "monoisotopic_mass": 40979.0 }, "refseq": { "ac": "NP_001017948", "name": "mitochondrial fission regulator 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" }, "gene_names": [ { "name": "MTFR2", "type": "recommended", "evidence": [ { "id": "Q58CR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ] }, { "name": "FAM54A", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" }, { "id": "Q58CR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ] }, { "name": "MTFR2", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" } ] } ], "protein_names": [ { "name": "Mitochondrial fission regulator 2", "type": "recommended", "evidence": [ { "id": "Q58CR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR1/entry#names_and_taxonomy" } ] }, { "name": "DUF729 domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" } ] }, { "name": "family with sequence similarity 54, member A", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" } ] }, { "name": "mitochondrial fission regulator 2", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" } ] }, { "name": "protein FAM54A", "type": "synonym", "evidence": [ { "id": "NP_001017948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948" } ] } ], "function": [ { "annotation": "May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1#function" } ] }, { "annotation": "Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RXP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXP1#function" }, { "database": "UniProtKB", "id": "RU369053", "url": "https://www.uniprot.org/uniprotkb/RU369053#function" }, { "database": "UniProtKB", "id": "A0AAA9T375", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T375#function" }, { "database": "UniProtKB", "id": "A0AAA9T631", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T631#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTFR2", "url": "https://www.uniprot.org/uniprotkb/Q58CR1", "locus": { "chromosome": "9", "start_pos": 74232905, "end_pos": 74250940, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007799", "url": "https://www.ensembl.org/id/ENSBTAG00000007799" } ] } } ], "crossref": [ { "id": "Q58CR1", "url": "https://alphafold.ebi.ac.uk/entry/Q58CR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534254", "url": "https://www.ncbi.nlm.nih.gov/gene/534254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534254", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534254", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VCQKKEY", "url": "https://omabrowser.org/oma/group/VCQKKEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58CR1", "url": "https://www.orthodb.org/?gene=Q58CR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001017948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017948", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T375", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T375", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T375-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T375-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T631", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T631", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T631-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T631-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CR1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKQCFFEFASVFASSMSFILSILREMLEYFGVPINQILHIWENKDYGSARSIVRIIGKLLPLEPCPRPNFELVPLLNSVDPANCGSVVPSFADVWCVANDEEASYLRFRTWKNEEEEKIASFHPLQLFEGPLTPAVRRNKPRKNDWPESETAIKKIAALEDELAFLRSQIAAIVGRQELGNSTKAGFLDLNGRPSGFGQKPSSGATQLNVKQDSFSSSVRPSSPPPPSPPQISSVQPPCSPLMKIASNSICASDNSTTEVKQQHPDAGKTNYSHHSKNQKNEAVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKREDSPWDPVSLISHALKQKFAFQEEDSFEKEDNCWESSPFSSPETSRVRL", "length": 366, "header": "sp|Q58CR1-1|MTFR2_BOVIN Isoform 1 of Mitochondrial fission regulator 2 OS=Bos taurus OX=9913 GN=MTFR2 PE=2 SV=1 CANONICAL=Q58CR1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXP1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1/entry#A0AAA9RXP1-1", "sequence": { "sequence": "TIQILHIWENKDYGSARSIVRIIGKLLPLEPCPRPNFELVPLLNSVDPANCGSVVPSFADVWCVANDEEASYLRFRTWKNEEEEKIASFHPLQLFEGPLTPAVRRNKPRKNDWPESETAIKKIAALEDELAFLRSQIAAIVGRQELGNSTKAGFLDLNGRPSGFGQKPSSGATQLNVKQDSFSSSVRPSSPPPPSPPQISSVQPPCSPLMKIASNSICASDNSTTEVKQQHPDAGKTNYSHHSKNQKNEAVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKREDSPWDPVSLISHALKQKFAFQEEDSFEKEDNCWESSPFSSPETSRVRL", "length": 332, "header": "tr|A0AAA9RXP1-1|MTFR2_BOVIN Computationally mapped isoform of Mitochondrial fission regulator 2 OS=Bos taurus OX=9913 GN=MTFR2 PE=2 SV=1 CANONICAL=Q58CR1-1" }, "locus": { "chromosome": "9", "start_pos": 74247064, "end_pos": 74234750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110107.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110107.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077317.1" } ] } }, { "isoform_ac": "A0AAA9T375-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1/entry#A0AAA9T375-1", "sequence": { "sequence": "TIHFLCDDLYGARTRDREPEPKAIRLHNARLPTQILHIWENKDYGSARSIVRIIGKLLPLEPCPRPNFELVPLLNSVDPANCGSVVPSFADVWCVANDEEASYLRFRTWKNEEEEKIASFHPLQLFEGPLTPAVRRNKPRKNDWPESETAIKKIAALEDELAFLRSQIAAIVGRQELGNSTKAGFLDLNGRPSGFGQKPSSGATQLNVKQDSFSSSVRPSSPPPPSPPQISSVQPPCSPLMKIASNSICASDNSTTEVKQQHPDAGKTNYSHHSKNQKNEAVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKREDSPWDPVSLISHALKQKFAFQEEDSFEKEDNCWESSPFSSPETSRVRL", "length": 363, "header": "tr|A0AAA9T375-1|A0AAA9T375_BOVIN Computationally mapped isoform of Mitochondrial fission regulator OS=Bos taurus OX=9913 GN=MTFR2 PE=3 SV=1 CANONICAL=Q58CR1-1" }, "locus": { "chromosome": "9", "start_pos": 74250938, "end_pos": 74234750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090142.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090142.1" } ] } }, { "isoform_ac": "A0AAA9T631-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1/entry#A0AAA9T631-1", "sequence": { "sequence": "MGKTRDLFKKIRDTNGTFHAKTGFIRTEMILHIWENKDYGSARSIVRIIGKLLPLEPCPRPNFELVPLLNSVDPANCGSVVPSFADVWCVANDEEASYLRFRTWKNEEEEKIASFHPLQLFEGPLTPAVRRNKPRKNDWPESETAIKKIAALEDELAFLRSQIAAIVGRQELGNSTKAGFLDLNGRPSGFGQKPSSGATQLNVKQDSFSSSVRPSSPPPPSPPQISSVQPPCSPLMKIASNSICASDNSTTEVKQQHPDAGKTNYSHHSKNQKNEAVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKREDSPWDPVSLISHALKQKFAFQEEDSFEKEDNCWESSPFSSPETSRVRL", "length": 358, "header": "tr|A0AAA9T631-1|A0AAA9T631_BOVIN Computationally mapped isoform of Mitochondrial fission regulator OS=Bos taurus OX=9913 GN=MTFR2 PE=3 SV=1 CANONICAL=Q58CR1-1" }, "locus": { "chromosome": "9", "start_pos": 74246705, "end_pos": 74234750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091228.1" } ] } }, { "isoform_ac": "Q58CR1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1/entry#Q58CR1-1", "sequence": { "sequence": "MKKQCFFEFASVFASSMSFILSILREMLEYFGVPINQILHIWENKDYGSARSIVRIIGKLLPLEPCPRPNFELVPLLNSVDPANCGSVVPSFADVWCVANDEEASYLRFRTWKNEEEEKIASFHPLQLFEGPLTPAVRRNKPRKNDWPESETAIKKIAALEDELAFLRSQIAAIVGRQELGNSTKAGFLDLNGRPSGFGQKPSSGATQLNVKQDSFSSSVRPSSPPPPSPPQISSVQPPCSPLMKIASNSICASDNSTTEVKQQHPDAGKTNYSHHSKNQKNEAVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKREDSPWDPVSLISHALKQKFAFQEEDSFEKEDNCWESSPFSSPETSRVRL", "length": 366, "header": "sp|Q58CR1-1|MTFR2_BOVIN Isoform 1 of Mitochondrial fission regulator 2 OS=Bos taurus OX=9913 GN=MTFR2 PE=2 SV=1 CANONICAL=Q58CR1-1" }, "locus": { "chromosome": "9", "start_pos": 74249182, "end_pos": 74234750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010261.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010261.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010261.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010261.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 306, "end_pos": 306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "site_lbl": "Ser306" }, { "start_pos": 343, "end_pos": 343, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "site_lbl": "Ser343" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:534254", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534254", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XNL4-1", "protein_name": "Mitochondrial fission regulator", "gene_name": "MTFR2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "RPGAPSASRCGHGAAAAPPAAPAGVPGLAARAGESRAERGSAARGGRAGVSWQEAPLRVLGSFLSVRSCLGVPWFRCLHSVLRRQAAFLETRVLGGGGVVRACLSSAVPSGGSVQQLCAALRRYQTKVISVCQRKEYGSTRSVVRRLGTILSLEPYPRPYFQLVHHPSPLDHDEQSVAPTPVAPSLADVLWVACDEGQAFARFRTELWRKEKSTAYHDFHPSIGSIPSVSKTSTQKDSLVNQAALQKISALEDELTFLRTQIATIVAAQTLGSIPSQPFRTFSIPDGSYPVPTMTSTPLSVSHNHFAIPSPPPLPSAAPSGVDASNSAIELIKQRRAARNSASTTGDSADPQRMKNIPSMMDVLKDLNKVQLRAIERSPGGTPVSKPKKRRSSDWDPVALLTHALKQKFAHKYEDEDDSLDKENRSFDSSPFSSPEIPLVGRCSLKTNANSSLVRTDKQVSVWKVRPHI", "length": 469 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FFM4-1", "protein_name": "Mitochondrial fission regulator", "gene_name": "Mtfr2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQREGPIEQCFLELASPMSLILNILRNMLAYFGVPVDQDFLTWQNKDYGSARSIIRIIGKMLPLEPCRRPNFELIPHLNSEEFDDYEPTVPSFADVLCVANDEEAGYLRFRHSPWKKEEEEKIALFHSPKLIWDPSLPALRQNKPVKNDLPASEAAIKKIAALEDELTFLRSQIAAIVAMQELRESKENYFALGFCDLSDEPSMEHTPSSATSGLNVEPDHSPSSVLSSPPSPPPLPQFSLQPCFPPMQPGSTNRDNPATAMEKQHSGVNKVNGSHHSESQRVSDVPNMLDILKDMNKVKLRPIERSPGGRPIQKQKRQSSQWDPVSLISNALKQKFAFQDDSFDIENRSWECSPFSSPETSRF", "length": 364 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S3R9-1", "protein_name": "Mitochondrial fission regulator", "gene_name": "MTFR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSFILSILRVMLEYFGVPINQVLQIWENKDYGSARSIVRIIGKILPLEPCPRPNFELIPFLNSVDSANCEPIVPSLADVLCVADDEEASYLRFRNSIWKNEEKEKLAFIHPLQLVEDPLSPALRHNKPRKNDWHENEAAIKKIAALEDELAFLRSQIAAIVSTQELRNSTNSGSLDLNDRPSGLGQMAPSENTPLSDEPDSFSSSVLPAPPPPPLPPQLSSLPPPCSPLLQPAADNICASDNSATEVKKQHADDRKTTCSHRSKNQKNKDVPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKRHNSPWDPVSLISHALKQKFASQEEDSFEKENNSWESSPFSSPETSRVRL", "length": 352 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08BD8-1", "protein_name": "Mitochondrial fission regulator 2", "gene_name": "mtfr2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLLEDIVDLLKCVLEYFGVPPDMLVPVWESTHCGQYRSLVRMIGTNLPLSPYPRLRFQIPLQTFNKHSHIDVSVDSPAIPTLADVLWLVEDEGDSHTKFRNAVPLRKKCVPHGYETPSLGSVSVKAQRGGGVLAQSTQPDALLKISALEEELQRLRAQIATIITAPAGPVVSPTDPGTPCSAPKPAPVLTSTPVCPPPPPPPPPPAMPTRTEVSMSEMIQQRQAAKKETLAQCGPSLTTAPSMLEVLRDLNQVKLRSVERSPGGTPIRRRRSKGVACSSDPAALIAEALKRKFAHRQRDDSFGKENHSAEPSPFSSPDTPRIFQHTRRSQGRIHL", "length": 336 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P444-1", "protein_name": "Mitochondrial fission regulator 2", "gene_name": "MTFR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLILNILREMLEYFGVPVEQVLLIWENKDYGSTRSIVRIIGKMLPLEPCRRPNFELIPLLNSVDSDNCGSMVPSFADILYVANDEEASYLRFRNSIWKNEEEKVEIFHPLRLVRDPLSPAVRQKETVKNDLPVNEAAIRKIAALENELTFLRSQIAAIVEMQELKNSTNSSSFGLSDERISLGQLSSSRAAHLSVDPDQLPGSVLSPPPPPPLPPQFSSLQPPCFPPVQPGSNNICDSDNPATEMSKQNPAANKTNYSHHSKSQRNKDIPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKRQNSHWDPVSLISHALKQKFAFQEDDSFEKENRSWESSPFSSPETSRFGHHISQSEGQRTKEEMVNTKAVDQGISNTSLLNSRI", "length": 385 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VED8-1", "protein_name": "Mitochondrial fission regulator 2", "gene_name": "Mtfr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRDGTNEQRFLELPSPMSFILNILRNVLEYFGVPVDQDLLICQNKNCGSARSIVRIIGRRLPLKPCRRPHFELIPHVNSTESDDYELRVPSFADVLCVANDEEASCLRFRHSLWQKKEERKIAPFYPSKLTWDPSSPGLRQNKTETDDLPVNEAAIKKIAALEDELTFLRSQIAAIVAMQDLRESRETGFIDLSDEQVPPSSATTGLSVEPDHAPSVVLPPPPPPPPPPQFSLQPPSSLPMQPGSANTHDIDSLATEMERQLSGVKKTDDSHHSKSQRLRDVPNMLDVLKDVNKVRLRPVERSPGGRPVQKRKRRSSEWDPVSLISNALKQKFAFQDDSFDRENSSWECSPFSSPETSRF", "length": 361 }, "evidence": [ { "id": "Q58CR1", "url": "https://omabrowser.org/oma/group/Q58CR1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial fission", "id": "GO:0000266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000266", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "Q58CR1", "url": "https://www.uniprot.org/uniprotkb/Q58CR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 366, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CR1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 306, 343 ], "sequon_annotation_sites": [ { "start_pos": 182, "end_pos": 184 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBI3-1", "uniprot_ac": "Q3ZBI3", "uniprot_id": "RNH2B_BOVIN", "mass": { "chemical_mass": 35008.0, "monoisotopic_mass": 35008.0 }, "refseq": { "ac": "NP_001160038", "name": "ribonuclease H2 subunit B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038" }, "gene_names": [ { "name": "RNASEH2B", "type": "recommended", "evidence": [ { "id": "Q3ZBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ] }, { "name": "RNASEH2B", "type": "synonym", "evidence": [ { "id": "NP_001160038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038" } ] } ], "protein_names": [ { "name": "Ribonuclease H2 subunit B", "type": "recommended", "evidence": [ { "id": "Q3ZBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#names_and_taxonomy" } ] }, { "name": "RNase H2 subunit B", "type": "synonym", "evidence": [ { "id": "NP_001160038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038" }, { "id": "Q3ZBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#names_and_taxonomy" } ] }, { "name": "Ribonuclease HI subunit B", "type": "synonym", "evidence": [ { "id": "Q3ZBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease H2 subunit B", "type": "synonym", "evidence": [ { "id": "NP_001160038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038" } ] }, { "name": "ribonuclease HI subunit B", "type": "synonym", "evidence": [ { "id": "NP_001160038", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038" } ] } ], "function": [ { "annotation": "Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S928", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S928#function" }, { "database": "UniProtKB", "id": "ARBA00024778", "url": "https://www.uniprot.org/uniprotkb/ARBA00024778#function" }, { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3#function" }, { "database": "UniProtKB", "id": "A0A3Q1MC88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC88#function" }, { "database": "UniProtKB", "id": "A0AAF6Z7G4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G4#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3Z6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z6#function" }, { "database": "UniProtKB", "id": "A0ABI0NKZ2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKZ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNASEH2B", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3", "locus": { "chromosome": "12", "start_pos": 20423652, "end_pos": 20346942, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020149", "url": "https://www.ensembl.org/id/ENSBTAG00000020149" } ] } } ], "crossref": [ { "id": "Q3ZBI3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020149", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09270", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09270", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509258", "url": "https://www.ncbi.nlm.nih.gov/gene/509258", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509258", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509258", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AQWVLIA", "url": "https://omabrowser.org/oma/group/AQWVLIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBI3", "url": "https://www.orthodb.org/?gene=Q3ZBI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13383:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13383:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09468", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09468", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17745", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17745", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001160038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160038", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3Z6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S928", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S928", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S928-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S928-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7G4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKZ2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARGADGGDGASVWQHVFLLPEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKESFQGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKKAKLSDEPVMAKEDYTKFNSKDFKTVKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHVKKK", "length": 309, "header": "sp|Q3ZBI3-1|RNH2B_BOVIN Isoform 1 of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=2 SV=2 CANONICAL=Q3ZBI3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3Z6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#A0A3Q1M3Z6-1", "sequence": { "sequence": "MARGADGGDGASVWQHVFLLPEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKESFQGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDVLSWPGHSVCLSMKNHDSDFYFSLLRLPEPPASVRNPPSKKAKLSDEPVMAKEDYTKFNSKDFKTVKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHVKKK", "length": 307, "header": "tr|A0A3Q1M3Z6-1|A0A3Q1M3Z6_BOVIN Computationally mapped isoform of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=3 SV=1 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20409546, "end_pos": 20347211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075284.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075284.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064504.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064504.1" } ] } }, { "isoform_ac": "A0A3Q1MC88-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#A0A3Q1MC88-1", "sequence": { "sequence": "MARGADGGDGASVWQHVFLLPEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKVAAQRQKRDK", "length": 254, "header": "tr|A0A3Q1MC88-1|A0A3Q1MC88_BOVIN Computationally mapped isoform of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=3 SV=2 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20422648, "end_pos": 20347211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066367.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066367.2" } ] } }, { "isoform_ac": "A0AAA9S928-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#A0AAA9S928-1", "sequence": { "sequence": "MARGADGGDGASVWQHVFLLPEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHVKKK", "length": 279, "header": "tr|A0AAA9S928-1|RNH2B_BOVIN Computationally mapped isoform of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=2 SV=1 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20409546, "end_pos": 20347211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081791.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081791.1" } ] } }, { "isoform_ac": "A0AAF6Z7G4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#A0AAF6Z7G4-1", "sequence": { "sequence": "MTQISLIIVLTSWEGLLKLAFLEAEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKKAKLSDEPVMAKEDYTKFNSKDFKTVKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHVKKK", "length": 309, "header": "tr|A0AAF6Z7G4-1|A0AAF6Z7G4_BOVIN Computationally mapped isoform of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=3 SV=1 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20409546, "end_pos": 20356655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026838.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026838.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026838.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026838.5" } ] } }, { "isoform_ac": "A0ABI0NKZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#A0ABI0NKZ2-1", "sequence": { "sequence": "MKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKVNPEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKKAKLSDEPVMAKEDYTKFNSKDFKTVKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHEKKIGKI", "length": 282, "header": "tr|A0ABI0NKZ2-1|A0ABI0NKZ2_BOVIN Computationally mapped isoform of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=3 SV=1 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20409557, "end_pos": 20370884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105276.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105276.1" } ] } }, { "isoform_ac": "Q3ZBI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3/entry#Q3ZBI3-1", "sequence": { "sequence": "MARGADGGDGASVWQHVFLLPEYLKDDSKKMKSGLVFVKLANPCSGEGTIYLFNMCLPQLFEIKVFKEKNHSWFINESVQSGGLLHFATPVDPLFLLLHYLIKADKESFQGKFQPLDQVVMDDMFPDCILLLKLPELEKLLQHVTEEKEVDKKKYYKYSKEKTLKWLGKKVNQTMAALKTNKVNVSARVQSTAFFSGGQVSSDKDEDYVRYAHGLISDYIPKQLSDDLSKYLKLPEPPASVRNPPSKKAKLSDEPVMAKEDYTKFNSKDFKTVKKNSKMTAAQKALAKVDKSGMKSIDSFFGTKHVKKK", "length": 309, "header": "sp|Q3ZBI3-1|RNH2B_BOVIN Isoform 1 of Ribonuclease H2 subunit B OS=Bos taurus OX=9913 GN=RNASEH2B PE=2 SV=2 CANONICAL=Q3ZBI3-1" }, "locus": { "chromosome": "12", "start_pos": 20409546, "end_pos": 20347211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104970.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104970.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091244.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091244.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 296, "end_pos": 296, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "site_lbl": "Ser296" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509258", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509258", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IKH0-1", "protein_name": "Ribonuclease H2 subunit B", "gene_name": "Rnaseh2b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAGRDRGDLAPRQLVFLLPEYLKDASKKMKSGLLFVKLANPRSGDGAIYLFDMCLQQLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFLLLHYLIKAGKEGKYQPLDQVVVDDLFPDCVLLLRFPELEKSLRHVTEEKEVNSKKYYKYSTEKTLKWLVKKVSQTVAALKANNVNVGARVQSSAYFSGDQVSKDKEEDYVRYAHGLISDYIPKELSDDLSKSLKLPEPPSSIPNPPSKKLKVSDEPVEAKEDYTKFNTKDLKTGKKNSKMTAAQKALAKVDKSGMKSIDAFFGAKNKKAGKI", "length": 307 }, "evidence": [ { "id": "Q3ZBI3", "url": "https://omabrowser.org/oma/group/Q3ZBI3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XEJ9-1", "protein_name": "Ribonuclease H2 subunit B", "gene_name": "RNASEH2B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHGAEQRPAGAHPDQWVLIAPEAATDPPKTPDSEPMFTKLRNPSTGEATLYLFNSGAQQLFEVKAFHEEYRSWFIGETVQQDGRLLFVTPMDPLFLILYYLIKADKEQQGKFQPLDQVVLDSEYPYCPLLLKCEGVKRSVRHITEEKEIGSQKFHKYSQEKTLKWLKKKVNQTVKALKSNNICVGERIYSATFVSGKQITDAEEDYVRYAHGLISEYITEELSKELSKYLGLPEHTVPGPEPPLKKRKLSDVPVEVEEDYTKFNSSNLKNKKTNSKMSAAQKALAKVDKSGMKSISSFFSSKPKASK", "length": 307 }, "evidence": [ { "id": "Q3ZBI3", "url": "https://omabrowser.org/oma/group/Q3ZBI3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5TBB1-1", "protein_name": "Ribonuclease H2 subunit B", "gene_name": "RNASEH2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTFFGVKNKKKIGKV", "length": 312 }, "evidence": [ { "id": "Q3ZBI3", "url": "https://omabrowser.org/oma/group/Q3ZBI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5XI96-1", "protein_name": "Ribonuclease H2 subunit B", "gene_name": "Rnaseh2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGGRDRGDLAARQLVFLLPEYLKDASRKSKSGLLFVKLVNPHSGEGATYLIDACLQKLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFLLLHYLIKAGKEGKYQPLDQVVVDDKFPDCTLLLRFPELEKSLRHVTEEKEVNSKKYYKYSTEKTLKWLEKKVNQTVAALKANHVNVGARVQSSAYFSGVQVSRDKEEDYVRYAHGLISDYIPKELSDDLSKLLKLPEPPASLPNPPAKKLKLADEPVEAKEDYTKFNTKDLKNGKKNSKMTAAQKALAKVDKSGMKSIDAFFGAKNKKTGKI", "length": 307 }, "evidence": [ { "id": "Q3ZBI3", "url": "https://omabrowser.org/oma/group/Q3ZBI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80ZV0-1", "protein_name": "Ribonuclease H2 subunit B", "gene_name": "Rnaseh2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGGRDRGDLAARQLVFLLPEHLKDASKKKKKSSLLFVKLANPHSGEGATYLIDMCLQQLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFLLLHYLLKAGKEGKYQPLDQVVVDDTFPDCTLLLRFPELEKSLRHVTEEKEVNSKKYYKYSSEKTLKWLEKKVNQTVVALKANNVNVGARVQSSAYFSGGQVSRDKEEDYVRYAHGLISDYIPKELSDDLSKFLKLPEPPASLTNPPSKKLKLSDEPVEAKEDYTKFNTKDLKTGKKNSKMTAAQKALAKVDKSGMKSIDAFFGAKNKKTGKI", "length": 308 }, "evidence": [ { "id": "Q3ZBI3", "url": "https://omabrowser.org/oma/group/Q3ZBI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "pmid": "" }, { "name": "ribonuclease H2 complex", "id": "GO:0032299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032299", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA catabolic process", "id": "GO:0006401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006401", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "pmid": "" }, { "name": "nucleobase-containing compound metabolic process", "id": "GO:0006139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006139", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 296 ], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHZ2-1", "uniprot_ac": "Q3MHZ2", "uniprot_id": "SPSB3_BOVIN", "mass": { "chemical_mass": 38181.0, "monoisotopic_mass": 38181.0 }, "refseq": { "ac": "NP_001029678", "name": "SPRY domain-containing SOCS box protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029678" }, "gene_names": [ { "name": "SPSB3", "type": "recommended", "evidence": [ { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ] }, { "name": "SPSB3", "type": "synonym", "evidence": [ { "id": "NP_001029678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029678" } ] }, { "name": "SSB3", "type": "synonym", "evidence": [ { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ] } ], "protein_names": [ { "name": "SPRY domain-containing SOCS box protein 3", "type": "recommended", "evidence": [ { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2/entry#names_and_taxonomy" } ] }, { "name": "SPRY domain-containing SOCS box protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029678" } ] }, { "name": "SSB-3", "type": "synonym", "evidence": [ { "id": "NP_001029678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029678" }, { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2#function" }, { "database": "UniProtKB", "id": "Q6PJ21", "url": "https://www.uniprot.org/uniprotkb/Q6PJ21#function" }, { "database": "UniProtKB", "id": "A0AAA9SG19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG19#function" }, { "database": "UniProtKB", "id": "ARBA00056941", "url": "https://www.uniprot.org/uniprotkb/ARBA00056941#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPSB3", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2", "locus": { "chromosome": "25", "start_pos": 1355612, "end_pos": 1361181, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016558", "url": "https://www.ensembl.org/id/ENSBTAG00000016558" } ] } } ], "crossref": [ { "id": "Q3MHZ2", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016558", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016558", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12876", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12876", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515661", "url": "https://www.ncbi.nlm.nih.gov/gene/515661", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515661", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515661", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MFHIDYS", "url": "https://omabrowser.org/oma/group/MFHIDYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHZ2", "url": "https://www.orthodb.org/?gene=Q3MHZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12245:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12245:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARRPRSSRAWHFVLSAARRDADARAVALAGTANWGYDSDGQHSDSDSDPECASLPSSIPSAVPVTGESFCDCDSQSEAFCGSLHTAHRGRDCRCGEEDEYFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATQLQNKRFYPMVCSTAAKSSMKVIRSCASVTSLQYLCCFRLRQLRPGSGDTLEGLPLPPGLKQVLHHKLGWVLSMSRQPPAPSPAANGPEPRRCQRKRCRRT", "length": 345, "header": "sp|Q3MHZ2-1|SPSB3_BOVIN Isoform 1 of SPRY domain-containing SOCS box protein 3 OS=Bos taurus OX=9913 GN=SPSB3 PE=2 SV=1 CANONICAL=Q3MHZ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG19-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2/entry#A0AAA9SG19-1", "sequence": { "sequence": "MDVWMVFHALYLSFIKVLGSWSELLSTMARRPRSSRAWHFVLSAARRDADARAVALAGTANWGYDSDGQHSDSDSDPECASLPSSIPSAVPVTGESFCDCDSQSEAFCGSLHTAHRGRDCRCGEEDEYFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATQLQNKRFYPMVCSTAAKSSMKVIRSCASVTSLQYLCCFRLRQLRPGSGDTLEGLPLPPGLKQVLHHKLGWVLSMSRQPPAPSPAANGPEPRRCQRKRCRRT", "length": 372, "header": "tr|A0AAA9SG19-1|SPSB3_BOVIN Computationally mapped isoform of SPRY domain-containing SOCS box protein 3 OS=Bos taurus OX=9913 GN=SPSB3 PE=2 SV=1 CANONICAL=Q3MHZ2-1" }, "locus": { "chromosome": "25", "start_pos": 1360122, "end_pos": 1356048, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113637.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113637.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084319.1" } ] } }, { "isoform_ac": "Q3MHZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2/entry#Q3MHZ2-1", "sequence": { "sequence": "MARRPRSSRAWHFVLSAARRDADARAVALAGTANWGYDSDGQHSDSDSDPECASLPSSIPSAVPVTGESFCDCDSQSEAFCGSLHTAHRGRDCRCGEEDEYFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATQLQNKRFYPMVCSTAAKSSMKVIRSCASVTSLQYLCCFRLRQLRPGSGDTLEGLPLPPGLKQVLHHKLGWVLSMSRQPPAPSPAANGPEPRRCQRKRCRRT", "length": 345, "header": "sp|Q3MHZ2-1|SPSB3_BOVIN Isoform 1 of SPRY domain-containing SOCS box protein 3 OS=Bos taurus OX=9913 GN=SPSB3 PE=2 SV=1 CANONICAL=Q3MHZ2-1" }, "locus": { "chromosome": "25", "start_pos": 1359935, "end_pos": 1356048, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022024.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022024.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022024.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022024.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515661", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515661", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AUC7-1", "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "SPSB3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRRPRSSRAWHFVLSAARRDADARAVALAGTPNWGYDSDGQHSDSDSDPECPNAPPSIPSAVPVTGESFCDCDSQSEAFCGSLHTAHRGRDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHTEYSCGTAAIRGTKELAEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATQLQNKRFYPMVCSTAAKSSMKVIRSCATITSLQYLCCYRLRQLRPDSGDTLEGLPLPPGLKQVLHHKLGWVLSMSCAHHKPPAPAPSPAASPSSPESRRCQRKRCRRT", "length": 352 }, "evidence": [ { "id": "Q3MHZ2", "url": "https://omabrowser.org/oma/group/Q3MHZ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZDG0-1", "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "SPSB3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARRTRSSRAWHFVLSGVRREADSRALALATGARGWGYDSDGQHSDSDSEPEFSTLSPSIPSAIPVTGESYCNCENQSEAPYCSSLHALHRVKDCQCGEEDEYFDWVWDDLNKSTATLLTCDNRKVNFHMEYSCGTAAIRGNKELADGQHFWEIKMTSPVYGTDMMVGIGTSDVNLDKYRHTFCSLLGKDEDSWGLSYTGLLHHKGDKTNFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATKLQNKKFYPMVCSTAAKSSMKVIRSCASCTSLQYLCCYRLRQLLPDYVDTLEVLPLPPGLKQVLHNKLGWVLSMNYSTSKPSSSSSGSDSDSSCGSDAEACQRKRCRRT", "length": 355 }, "evidence": [ { "id": "Q3MHZ2", "url": "https://omabrowser.org/oma/group/Q3MHZ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LAI2-1", "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "Spsb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMTPRTRTYFRILIQWSCEIFLIALPKANRNFGSGLTGCASLLTAVLSRETRPRAKLSDSPPSAAGPMQRGGGDCLRRDRNGKWVSPGGARWLQVLFTMARRARSSRAWHFVLSAARRDTDARAVALAGNSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEGECLAVGTCAGLGRFSGLEGSTLLCPSLVWAFYPTDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCSHWTSPAPPPGTAAPAAERDSRETRPCQRKRCRRS", "length": 489 }, "evidence": [ { "id": "Q3MHZ2", "url": "https://omabrowser.org/oma/group/Q3MHZ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q571F5-1", "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "Spsb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARRTRSSRAWHFVLSAARRDTDARAVALAGSSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPNSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCNHWKSPVPPPGTATPGAESLETRPCQRKRCRRS", "length": 354 }, "evidence": [ { "id": "Q3MHZ2", "url": "https://omabrowser.org/oma/group/Q3MHZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PJ21-1", "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "SPSB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARRPRNSRAWHFVLSAARRDADARAVALAGSTNWGYDSDGQHSDSDSDPEYSTLPPSIPSAVPVTGESFCDCAGQSEASFCSSLHSAHRGRDCRCGEEDEYFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASATSLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAATSAHPSSREPRPCQRKRCRRT", "length": 355 }, "evidence": [ { "id": "Q3MHZ2", "url": "https://omabrowser.org/oma/group/Q3MHZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" }, { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" }, { "name": "negative regulation of cGAS/STING signaling pathway", "id": "GO:0160049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160049", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ2", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHZ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" }, { "id": "PRU00548", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00548" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000255", "start_pos": 84, "end_pos": 273, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ2" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 263, "end_pos": 314, "start_aa": "Ser", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DF6-1", "uniprot_ac": "Q58DF6", "uniprot_id": "SCAM4_BOVIN", "mass": { "chemical_mass": 25595.0, "monoisotopic_mass": 25595.0 }, "refseq": { "ac": "NP_001019737", "name": "secretory carrier-associated membrane protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019737" }, "gene_names": [ { "name": "SCAMP4", "type": "recommended", "evidence": [ { "id": "Q58DF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ] }, { "name": "SCAMP4", "type": "synonym", "evidence": [ { "id": "NP_001019737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019737" } ] } ], "protein_names": [ { "name": "Secretory carrier-associated membrane protein 4", "type": "recommended", "evidence": [ { "id": "Q58DF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF6/entry#names_and_taxonomy" } ] }, { "name": "Secretory carrier membrane protein 4", "type": "synonym", "evidence": [ { "id": "Q58DF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF6/entry#names_and_taxonomy" } ] }, { "name": "secretory carrier-associated membrane protein 4", "type": "synonym", "evidence": [ { "id": "NP_001019737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019737" } ] } ], "function": [ { "annotation": "Probably involved in membrane protein trafficking.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL6#function" }, { "database": "UniProtKB", "id": "ARBA00037350", "url": "https://www.uniprot.org/uniprotkb/ARBA00037350#function" }, { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6#function" }, { "database": "UniProtKB", "id": "A0AAA9S938", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S938#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCAMP4", "url": "https://www.uniprot.org/uniprotkb/Q58DF6", "locus": { "chromosome": "7", "start_pos": 44237061, "end_pos": 44220151, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045762", "url": "https://www.ensembl.org/id/ENSBTAG00000045762" } ] } } ], "crossref": [ { "id": "Q58DF6", "url": "https://alphafold.ebi.ac.uk/entry/Q58DF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045762", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045762", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538819", "url": "https://www.ncbi.nlm.nih.gov/gene/538819", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538819", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538819", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPTGNQW", "url": "https://omabrowser.org/oma/group/YPTGNQW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DF6", "url": "https://www.orthodb.org/?gene=Q58DF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10687", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10687", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10687:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10687:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019737", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S938", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S938", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S938-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S938-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DF6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGKENNFPPLPKFIPLKPCFYQNFSDEIPIEHQVLVKRIYRLWLFYCATLGVNLVACLAWWIAGGSGANFGLALLWLLLFSPCGYVCWFRPAYKAFRSDSSFNFMAFFFIFGAQFILTIIQAVGFSGWGACGWLAAIGFFQTSVGAAVVMLLPAIMFSMSAAMMAVMIMKVHSIYRGTGGSFQKAQTEWSTGTWRNPPSREAQFNNFSGNSLPEYPTVPSYPASGGQWP", "length": 230, "header": "sp|Q58DF6-1|SCAM4_BOVIN Isoform 1 of Secretory carrier-associated membrane protein 4 OS=Bos taurus OX=9913 GN=SCAMP4 PE=2 SV=1 CANONICAL=Q58DF6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S938-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF6/entry#A0AAA9S938-1", "sequence": { "sequence": "MFSGSVHEAVAAGFHSHPVFAAEMSGKENNFPPLPKFIPLKPCFYQNFSDEIPIEHQVLVKRIYRLWLFYCATLGVNLVACLAWWIAGGSGANFGLALLWLLLFSPCGYVCWFRPAYKAFRSDSSFNFMAFFFIFGAQFILTIIQAVGFSGWGACGWLAAIGFFQTSVGAAVVMLLPAIMFSMSAAMMAVMIMKVHSIYRGTGGSFQKAQTEWSTGTWRNPPSREAQFNNFSGNSLPEYPTVPSYPASGGQWP", "length": 253, "header": "tr|A0AAA9S938-1|A0AAA9S938_BOVIN Computationally mapped isoform of Secretory carrier-associated membrane protein OS=Bos taurus OX=9913 GN=SCAMP4 PE=3 SV=1 CANONICAL=Q58DF6-1" }, "locus": { "chromosome": "7", "start_pos": 44235706, "end_pos": 44223060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094625.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094625.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079892.1" } ] } }, { "isoform_ac": "A0AAA9SGL6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF6/entry#A0AAA9SGL6-1", "sequence": { "sequence": "MSGKENNFPPLPKFIPLKPCFYQNFSDEIPIEHQVLVKRIYRLWLFYCATLGVNLVACLAWWIAGGSGANFGLALLWLLLFSPCGYVCWFRPAYKAFRGWLAAIGFFQTSVGAAVVMLLPAIMFSMSAAMMAVMIMKVHSIYRGTGGSFQKAQTEWSTGTWRNPPSREAQFNNFSGNSLPEYPTVPSYPASGGQWP", "length": 196, "header": "tr|A0AAA9SGL6-1|SCAM4_BOVIN Computationally mapped isoform of Secretory carrier-associated membrane protein 4 OS=Bos taurus OX=9913 GN=SCAMP4 PE=2 SV=1 CANONICAL=Q58DF6-1" }, "locus": { "chromosome": "7", "start_pos": 44235706, "end_pos": 44227170, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085324.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085324.1" } ] } }, { "isoform_ac": "Q58DF6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF6/entry#Q58DF6-1", "sequence": { "sequence": "MSGKENNFPPLPKFIPLKPCFYQNFSDEIPIEHQVLVKRIYRLWLFYCATLGVNLVACLAWWIAGGSGANFGLALLWLLLFSPCGYVCWFRPAYKAFRSDSSFNFMAFFFIFGAQFILTIIQAVGFSGWGACGWLAAIGFFQTSVGAAVVMLLPAIMFSMSAAMMAVMIMKVHSIYRGTGGSFQKAQTEWSTGTWRNPPSREAQFNNFSGNSLPEYPTVPSYPASGGQWP", "length": 230, "header": "sp|Q58DF6-1|SCAM4_BOVIN Isoform 1 of Secretory carrier-associated membrane protein 4 OS=Bos taurus OX=9913 GN=SCAMP4 PE=2 SV=1 CANONICAL=Q58DF6-1" }, "locus": { "chromosome": "7", "start_pos": 44235706, "end_pos": 44227170, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065646.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065646.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000055576.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "site_lbl": "Thr194" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538819", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538819", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AB36-1", "protein_name": "Secretory carrier-associated membrane protein", "gene_name": "SCAMP4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEKVNNFPPLPKFIPLKPCFYQNFSDEIPIDYQSLVKRIYHVWIFYCITLVVNIIACLAWWIGGGYGVNFGLAILWLILFSPCSYVCWFRPVYKAFRSDSSFNFMTFFFVFGLQFVLTFLQAVGFSGWGACGWLAAITFFSTNVAAAVFMLFPAIMFTMAALAMLVCILRVHKIYRGAGGSFQKAQDEWHSGAWRNPPSREAQYNNFAGNSLPEYPTVPNYPSGNQWP", "length": 229 }, "evidence": [ { "id": "Q58DF6", "url": "https://omabrowser.org/oma/group/Q58DF6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SDH4-1", "protein_name": "Secretory carrier-associated membrane protein", "gene_name": "SCAMP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGKENNFPPLPKFIPLKPCFYQNFSDEIPIEHQVLVKRIYQLWLFYCATLGVNLVACLAWWIAAGSGANFGLALVWLLLFSPCGYVCWFRPAYKAFRSDSSFNFMAFFFIFGAQFVLAVIQAIGFSGWGTCGWLAAIGFFQINVGAAVVMLLPAIMFSVSAAIMAIVIMKVHRIYRGTGGSFQKAQTEWSTGAWRNPPSREAQYNNFSGNSLPEYPTVPSYPASGSQWP", "length": 230 }, "evidence": [ { "id": "Q58DF6", "url": "https://omabrowser.org/oma/group/Q58DF6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q969E2-1", "protein_name": "Secretory carrier-associated membrane protein 4", "gene_name": "SCAMP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLIACLAWWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRADSSFNFMAFFFIFGAQFVLTVIQAIGFSGWGACGWLSAIGFFQYSPGAAVVMLLPAIMFSVSAAMMAIAIMKVHRIYRGAGGSFQKAQTEWNTGTWRNPPSREAQYNNFSGNSLPEYPTVPSYPGSGQWP", "length": 229 }, "evidence": [ { "id": "Q58DF6", "url": "https://omabrowser.org/oma/group/Q58DF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ET20-1", "protein_name": "Secretory carrier-associated membrane protein 4", "gene_name": "Scamp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKENNFPPLPHFLPLKPCFYQDFSDEIPVEHQVLVKRIYRLWMFYCTTLGVNLVACLAWWIAGGAGANFGLAMLWLVLFTPCSYVCWFRPAYKAFRADSSFNFMAFFFIFGAQFVLTVIQAIGFSGWGACGWLATIGFFGTSVGAAVVMLIPAIMFSLSAVVMAITIVKVHRIYRGAGGSLQKAQTEWSAGTWRNPPSREAQFNSFSGNSLPEYPTVPSYSTSGSQWP", "length": 230 }, "evidence": [ { "id": "Q58DF6", "url": "https://omabrowser.org/oma/group/Q58DF6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JKV5-1", "protein_name": "Secretory carrier-associated membrane protein 4", "gene_name": "Scamp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGKENNFPPLPPFLPLKPCFYQDFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLVACLAWWIAGGAGANFGLALLWLVLFTPCSYVCWFRPAYKAFRADSSFNFMTFFFIFGAQFVLTVIQAIGFSGWGACGWLAAVGFFGTSVGAAVVMLVPAILFSLSALVMAVTIVKVHRIYRGAGGSLQKAQTEWSAGTWRNPPSREAQFNSFSGNSLPEYPTVPSYSSSGGHWP", "length": 230 }, "evidence": [ { "id": "Q58DF6", "url": "https://omabrowser.org/oma/group/Q58DF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58DF6", "url": "https://www.uniprot.org/uniprotkb/Q58DF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DF6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DF6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DF6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 194 ], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 }, { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBC2-1", "uniprot_ac": "Q3ZBC2", "uniprot_id": "SDHF2_BOVIN", "mass": { "chemical_mass": 19604.0, "monoisotopic_mass": 19604.0 }, "refseq": { "ac": "NP_001070513", "name": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" }, "gene_names": [ { "name": "SDHAF2", "type": "recommended", "evidence": [ { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ] }, { "name": "PGL2", "type": "synonym", "evidence": [ { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ] }, { "name": "SDH5", "type": "synonym", "evidence": [ { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ] }, { "name": "SDHAF2", "type": "synonym", "evidence": [ { "id": "NP_001070513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" } ] } ], "protein_names": [ { "name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#names_and_taxonomy" } ] }, { "name": "SDH assembly factor 2", "type": "synonym", "evidence": [ { "id": "NP_001070513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" }, { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#names_and_taxonomy" } ] }, { "name": "SDHAF2", "type": "synonym", "evidence": [ { "id": "Q3ZBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#names_and_taxonomy" } ] }, { "name": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001070513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" } ] }, { "name": "succinate dehydrogenase assembly factor 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001070513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" } ] }, { "name": "succinate dehydrogenase subunit 5, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001070513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513" } ] } ], "function": [ { "annotation": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ46#function" }, { "database": "HAMAP", "id": "MF_03057", "url": "https://hamap.expasy.org/signature/MF_03057" }, { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDHAF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2", "locus": { "chromosome": "29", "start_pos": 39931372, "end_pos": 39921797, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015266", "url": "https://www.ensembl.org/id/ENSBTAG00000015266" } ] } } ], "crossref": [ { "id": "Q3ZBC2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015266", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015266", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767983", "url": "https://www.ncbi.nlm.nih.gov/gene/767983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767983", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGKPQNP", "url": "https://omabrowser.org/oma/group/YGKPQNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBC2", "url": "https://www.orthodb.org/?gene=Q3ZBC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12469", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12469", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12469:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12469:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9854311", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070513", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U210", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U210", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U210-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U210-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBC2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVAVFPALARMLAVSRRRLVSPSLSMTSCRRCYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMTLLRDFAKNKNKEQRLRAPDLEYLFEKPH", "length": 166, "header": "sp|Q3ZBC2-1|SDHF2_BOVIN Isoform 1 of Succinate dehydrogenase assembly factor 2, mitochondrial OS=Bos taurus OX=9913 GN=SDHAF2 PE=2 SV=1 CANONICAL=Q3ZBC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCP1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#A0AAA9SCP1-1", "sequence": { "sequence": "MAVVAVFPALARKQNQPQKYLKTKSPC", "length": 27, "header": "tr|A0AAA9SCP1-1|A0AAA9SCP1_BOVIN Computationally mapped isoform of Succinate dehydrogenase complex assembly factor 2 OS=Bos taurus OX=9913 GN=SDHAF2 PE=4 SV=1 CANONICAL=Q3ZBC2-1" }, "locus": { "chromosome": "29", "start_pos": 39930690, "end_pos": 39921934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102148.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102148.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083891.1" } ] } }, { "isoform_ac": "A0AAA9SJ46-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#A0AAA9SJ46-1", "sequence": { "sequence": "MQGKKKIFPLETFWEGTVSPSLSMTSCRRCYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMTLLRDFAKNKNKEQRLRAPDLEYLFEKPH", "length": 162, "header": "tr|A0AAA9SJ46-1|SDHF2_BOVIN Computationally mapped isoform of Succinate dehydrogenase assembly factor 2, mitochondrial OS=Bos taurus OX=9913 GN=SDHAF2 PE=2 SV=1 CANONICAL=Q3ZBC2-1" }, "locus": { "chromosome": "29", "start_pos": 39930770, "end_pos": 39926452, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096805.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096805.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083935.1" } ] } }, { "isoform_ac": "A0AAA9U210-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#A0AAA9U210-1", "sequence": { "sequence": "MAVVAVFPALARMLAVSRRRLVSPSLSMTSCRRCYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGTRHDKQHKVKTGCGLI", "length": 140, "header": "tr|A0AAA9U210-1|A0AAA9U210_BOVIN Computationally mapped isoform of Succinate dehydrogenase complex assembly factor 2 OS=Bos taurus OX=9913 GN=SDHAF2 PE=4 SV=1 CANONICAL=Q3ZBC2-1" }, "locus": { "chromosome": "29", "start_pos": 39927470, "end_pos": 39921934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112267.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112267.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103965.1" } ] } }, { "isoform_ac": "Q3ZBC2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2/entry#Q3ZBC2-1", "sequence": { "sequence": "MAVVAVFPALARMLAVSRRRLVSPSLSMTSCRRCYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMTLLRDFAKNKNKEQRLRAPDLEYLFEKPH", "length": 166, "header": "sp|Q3ZBC2-1|SDHF2_BOVIN Isoform 1 of Succinate dehydrogenase assembly factor 2, mitochondrial OS=Bos taurus OX=9913 GN=SDHAF2 PE=2 SV=1 CANONICAL=Q3ZBC2-1" }, "locus": { "chromosome": "29", "start_pos": 39930770, "end_pos": 39921934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153830.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153830.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106618.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106618.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767983", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767983", "resource": "KEGG Pathway" }, { "id": "R-BTA-9854311", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "resource": "Reactome", "description": "Maturation of TCA enzymes and regulation of TCA cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FKT3-1", "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "SDHAF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVATVFPALSRGLALSRRHLVSPLFSVTSFRRSYRGDSPTDSQTDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLHQMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVLALLRDFAKNKNREQRLRAPDLEYLFEKPR", "length": 166 }, "evidence": [ { "id": "Q3ZBC2", "url": "https://omabrowser.org/oma/group/Q3ZBC2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A3KP74-1", "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "sdhaf2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFSANIARKVVCSVCRASLRPTVCPVVYRGYRGDAPEPTILEIPLPPWQERAGEALDIKRKRLLYESRKRGMLENCILLSLFAKQYLNTMSESQLKQYDRLINEPSNDWDIYYWATDTQPTPEVYQGEVMDMLKEFTKNRDMEQRLDAPNLEYLDKSS", "length": 158 }, "evidence": [ { "id": "Q3ZBC2", "url": "https://omabrowser.org/oma/group/Q3ZBC2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q08230-1", "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "SDH5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKIAPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ", "length": 162 }, "evidence": [ { "id": "Q3ZBC2", "url": "https://omabrowser.org/oma/group/Q3ZBC2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4V5I9-1", "protein_name": "Succinate dehydrogenase assembly factor 2-A, mitochondrial", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRQLRLTMDISGWIFLPWRRSMSNMKDSPPPPPPLASTFNDVIVDYEDPDYLPLPEYPVRPNEPLETRKQRLLYQSRKRGMLENDLLLSTFAAKHLQNFSAEQTAQYDQLINGVSNDWDIYYWATEVKPTPKEYDTEIMGLLKEHVKNAERVTRLRQPDLNI", "length": 163 }, "evidence": [ { "id": "Q3ZBC2", "url": "https://omabrowser.org/oma/group/Q3ZBC2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8C6I2-1", "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "Sdhaf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVVTLIPTLARALSKHSLLSPLPSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEYLHNMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMELLREFAKNKNKEQRLRAPDLEYLFEKPH", "length": 164 }, "evidence": [ { "id": "Q3ZBC2", "url": "https://omabrowser.org/oma/group/Q3ZBC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "tricarboxylic acid cycle", "id": "GO:0006099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006099", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "mitochondrial electron transport, succinate to ubiquinone", "id": "GO:0006121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006121", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "protein-FAD linkage", "id": "GO:0018293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018293", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex II assembly", "id": "GO:0034553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034553", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBC2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ58-1", "uniprot_ac": "Q2KJ58", "uniprot_id": "R3GEF_BOVIN", "mass": { "chemical_mass": 43325.0, "monoisotopic_mass": 43325.0 }, "refseq": { "ac": "NP_001039997", "name": "guanine nucleotide exchange factor for Rab-3A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" }, "gene_names": [ { "name": "RAB3IL1", "type": "recommended", "evidence": [ { "id": "Q2KJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ] }, { "name": "RAB3IL1", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] } ], "protein_names": [ { "name": "Guanine nucleotide exchange factor for Rab-3A", "type": "recommended", "evidence": [ { "id": "Q2KJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#names_and_taxonomy" } ] }, { "name": "RAB3A interacting protein (rabin3)-like 1", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] }, { "name": "Rab-3A-interacting-like protein 1", "type": "synonym", "evidence": [ { "id": "Q2KJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#names_and_taxonomy" } ] }, { "name": "Rab3A-interacting-like protein 1", "type": "synonym", "evidence": [ { "id": "Q2KJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#names_and_taxonomy" } ] }, { "name": "Rabin3-like 1", "type": "synonym", "evidence": [ { "id": "Q2KJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#names_and_taxonomy" } ] }, { "name": "guanine nucleotide exchange factor for Rab-3A", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] }, { "name": "guanine nucleotide exchange factor for Rab3A", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] }, { "name": "rab-3A-interacting-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] }, { "name": "rab3A-interacting-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] }, { "name": "rabin3-like 1", "type": "synonym", "evidence": [ { "id": "NP_001039997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997" } ] } ], "function": [ { "annotation": "Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB3IL1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58", "locus": { "chromosome": "29", "start_pos": 40417001, "end_pos": 40441946, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015745", "url": "https://www.ensembl.org/id/ENSBTAG00000015745" } ] } } ], "crossref": [ { "id": "Q2KJ58", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015745", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015745", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614335", "url": "https://www.ncbi.nlm.nih.gov/gene/614335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040351", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040351", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614335", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614335", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LF65", "url": "https://www.orthodb.org/?gene=A0A3Q1LF65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LGV1", "url": "https://www.orthodb.org/?gene=A0A3Q1LGV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAI7", "url": "https://www.orthodb.org/?gene=A0A3Q1MAI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCS7", "url": "https://www.orthodb.org/?gene=A0A3Q1MCS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ58", "url": "https://www.orthodb.org/?gene=Q2KJ58", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14430:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14430:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06428", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06428", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25555", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25555", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGV1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAI7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAI7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1Y8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1Y8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ58-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 390, "header": "sp|Q2KJ58-1|R3GEF_BOVIN Isoform 1 of Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus OX=9913 GN=RAB3IL1 PE=2 SV=1 CANONICAL=Q2KJ58-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF65-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0A3Q1LF65-1", "sequence": { "sequence": "MHSVPLSQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 393, "header": "tr|A0A3Q1LF65-1|R3GEF_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus OX=9913 GN=RAB3IL1 PE=2 SV=2 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40427490, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081951.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081951.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056721.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056721.2" } ] } }, { "isoform_ac": "A0A3Q1LGV1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0A3Q1LGV1-1", "sequence": { "sequence": "SWPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 387, "header": "tr|A0A3Q1LGV1-1|R3GEF_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus OX=9913 GN=RAB3IL1 PE=2 SV=2 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40427354, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069355.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069355.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057789.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057789.2" } ] } }, { "isoform_ac": "A0A3Q1MAI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0A3Q1MAI7-1", "sequence": { "sequence": "MDPAEKPAECPARGKCPVFLAVSSGTVRYAPSGLGPALEGNLGKQPWDTDSQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 356, "header": "tr|A0A3Q1MAI7-1|A0A3Q1MAI7_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=2 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40438644, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081652.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081652.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067232.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067232.2" } ] } }, { "isoform_ac": "A0A3Q1MCS7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0A3Q1MCS7-1", "sequence": { "sequence": "MDPAEKPAECPARGKCPVFLAVSSGTVRYAPSGLGPALEGNLGKQPWDTDSQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEPGLPPLLSLLLCVVPSKAAHLTYEPAWQLPPGELPVGLTSATSLSFSRQVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 478, "header": "tr|A0A3Q1MCS7-1|A0A3Q1MCS7_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=2 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40438644, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076278.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076278.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068180.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068180.2" } ] } }, { "isoform_ac": "A0AAA9S0Y9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0AAA9S0Y9-1", "sequence": { "sequence": "MAKGPGEREGVAGRPLRIRELKAWSHGRCLSKGGLARVLRGAGWSGVSWEHQRAARAAGCCQSGRAARAGLGRERARVLRIGRRRGGAGHVSSGHPLGHVTAEGRVAAGPGARAAQTHRQRAGLTGGGAARRAPGGVGGGRGRREELAGRSPRRRREPTPGGPPGAGMWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 557, "header": "tr|A0AAA9S0Y9-1|A0AAA9S0Y9_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=1 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40435871, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119238.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119238.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078641.1" } ] } }, { "isoform_ac": "A0AAA9TRA2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0AAA9TRA2-1", "sequence": { "sequence": "MWPPHPGRWQRALAAFQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 402, "header": "tr|A0AAA9TRA2-1|A0AAA9TRA2_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=1 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40441771, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099554.1" } ] } }, { "isoform_ac": "A0AAA9TVL6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0AAA9TVL6-1", "sequence": { "sequence": "MAKGPGEREGVAGRPLRIRELKAWSHGRCLSKGGLARVLRGAGWSGVSWEHQRAARAAGCCQSGRAARAGLGRERARVLRIGRRRGGAGHVSSGHPLGHVTAEGRVAAGPGARAAQTHRQRAGLTGGGAARRAPGGVGGGRGRREELAGRSPRRRREPTPGGPPGAGMWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTGCRGWSFGIPGLRLTKPSCPTGVSTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 581, "header": "tr|A0AAA9TVL6-1|A0AAA9TVL6_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=1 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40435871, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112095.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102659.1" } ] } }, { "isoform_ac": "A0AAF6Z1Y8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#A0AAF6Z1Y8-1", "sequence": { "sequence": "MWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 358, "header": "tr|A0AAF6Z1Y8-1|A0AAF6Z1Y8_BOVIN Computationally mapped isoform of RAB3A interacting protein like 1 OS=Bos taurus OX=9913 GN=RAB3IL1 PE=3 SV=1 CANONICAL=Q2KJ58-1" }, "locus": { "chromosome": "29", "start_pos": 40435370, "end_pos": 40417900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020909.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020909.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020909.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020909.5" } ] } }, { "isoform_ac": "Q2KJ58-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58/entry#Q2KJ58-1", "sequence": { "sequence": "MWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA", "length": 390, "header": "sp|Q2KJ58-1|R3GEF_BOVIN Isoform 1 of Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus OX=9913 GN=RAB3IL1 PE=2 SV=1 CANONICAL=Q2KJ58-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 168, "end_pos": 168, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ], "site_lbl": "Ser168" }, { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ], "site_lbl": "Ser179" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614335", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614335", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ58", "url": "https://www.uniprot.org/uniprotkb/Q2KJ58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ58-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 390, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ58-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ58" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 168, 179 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIL7-1", "uniprot_ac": "Q2KIL7", "uniprot_id": "R3HD4_BOVIN", "mass": { "chemical_mass": 30777.0, "monoisotopic_mass": 30777.0 }, "refseq": { "ac": "NP_001040013", "name": "R3H domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" }, "gene_names": [ { "name": "R3HDM4", "type": "recommended", "evidence": [ { "id": "Q2KIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7" } ] }, { "name": "C19orf22", "type": "synonym", "evidence": [ { "id": "NP_001040013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" } ] }, { "name": "C7H19orf22", "type": "synonym", "evidence": [ { "id": "NP_001040013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" } ] }, { "name": "R3HDM4", "type": "synonym", "evidence": [ { "id": "NP_001040013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" } ] } ], "protein_names": [ { "name": "R3H domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q2KIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#names_and_taxonomy" } ] }, { "name": "R3H domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001040013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" } ] }, { "name": "R3H domain-containing protein C19orf22 homolog", "type": "synonym", "evidence": [ { "id": "NP_001040013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIL7", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "R3HDM4", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7", "locus": { "chromosome": "7", "start_pos": 43439383, "end_pos": 43453035, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046406", "url": "https://www.ensembl.org/id/ENSBTAG00000046406" } ] } } ], "crossref": [ { "id": "Q2KIL7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIL7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046406", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02325", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02325", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614948", "url": "https://www.ncbi.nlm.nih.gov/gene/614948", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614948", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614948", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NATYMEV", "url": "https://omabrowser.org/oma/group/NATYMEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMI2", "url": "https://www.orthodb.org/?gene=A0A3Q1MMI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIL7", "url": "https://www.orthodb.org/?gene=Q2KIL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32019:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32019:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJB4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJB4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2V5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2V5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMI2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMI2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZPH2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZPH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIL7", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIL7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVLENPEAGPEEAAAAARVVPGGRRTLPLPGCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 272, "header": "sp|Q2KIL7-1|R3HD4_BOVIN Isoform 1 of R3H domain-containing protein 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=2 SV=1 CANONICAL=Q2KIL7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJB4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#A0A3Q1LJB4-1", "sequence": { "sequence": "VPCQAEQHQRAEEKRHQPGVHGPRRRDRAVRGVGATARADRCVGRRPPGRVRPRRGQGLHCHPLRPDHPPGFHPAIAAVTFRIALRGCATKSGSQLSWNPQLQPLRVYTPHPTVPRLPASPSASGHSLPCLCAHCSPEQHPAPASRPPPPRPLPGCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 395, "header": "tr|A0A3Q1LJB4-1|R3HD4_BOVIN Computationally mapped isoform of R3H domain-containing protein 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=2 SV=2 CANONICAL=Q2KIL7-1" }, "locus": { "chromosome": "7", "start_pos": 43452942, "end_pos": 43440273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083096.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083096.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059446.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059446.2" } ] } }, { "isoform_ac": "A0A3Q1M2V5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#A0A3Q1M2V5-1", "sequence": { "sequence": "MDCNMLGFPVHHQFPELAQTHVHRVGGAIQPSHPLSSPSPPAFNLPSIRVFSNESVLRIRWPKYWSLSFSISPFNVVSLEKSKLRRSAGIRRLLFEGGSRRGLVEGEPCCRWGVGWGGVWHGALGLSKHLKRTSPSCLPPQASISPLSPGGRGHSPAAARGPLCPLGLGLRCPRPCLGAGCPRPAAGAWPGRGRASARRVQPPGSALARLRAPVTSCRAQRRPCRAAAAAAAAESKLWSFWRTLRPVPRKQRRRRGSSRAGGGRSQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 457, "header": "tr|A0A3Q1M2V5-1|A0A3Q1M2V5_BOVIN Computationally mapped isoform of R3H domain containing 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=4 SV=1 CANONICAL=Q2KIL7-1" }, "locus": { "chromosome": "7", "start_pos": 43449545, "end_pos": 43440273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070652.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070652.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064171.1" } ] } }, { "isoform_ac": "A0A3Q1MMI2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#A0A3Q1MMI2-1", "sequence": { "sequence": "MVVLENPEAGPEEAAAAARVVPGGRRTLNPRGPPWLLVPFLLLHGRPSGLGRPLPGCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 296, "header": "tr|A0A3Q1MMI2-1|A0A3Q1MMI2_BOVIN Computationally mapped isoform of R3H domain containing 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=4 SV=1 CANONICAL=Q2KIL7-1" }, "locus": { "chromosome": "7", "start_pos": 43448835, "end_pos": 43440273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073011.1" } ] } }, { "isoform_ac": "A0AAA9TB69-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#A0AAA9TB69-1", "sequence": { "sequence": "MDCNMLGFPVHHQFPELAQTHVHRVGGAIQPSHPLSSPSPPAFNLPSIRVFSNESVLRIRWPKYWSLSFSISPFNVVSLEKSKLRRSAGIRRLLFEGGSRRGLVEGEPCCRWGVGWGGVWHGALGLSKHLKRTSPSCLPPQASISPLSPGGRGHSPAAARGPLCPLGLGLRCPRPCLGAGCPRPAAGAWPGRGRASARRVQPPGSALARLRAPVTSCRAQRRPCRAAAAAAAAESKLWSFWRTLRPVPRKQRRRRGSSRAGGGRSSSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 499, "header": "tr|A0AAA9TB69-1|A0AAA9TB69_BOVIN Computationally mapped isoform of R3H domain containing 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=4 SV=1 CANONICAL=Q2KIL7-1" }, "locus": { "chromosome": "7", "start_pos": 43449545, "end_pos": 43440273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090524.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090524.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093918.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093918.1" } ] } }, { "isoform_ac": "A0AAF6ZPH2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#A0AAF6ZPH2-1", "sequence": { "sequence": "SHCRGKPSWGWLPLPGCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 256, "header": "tr|A0AAF6ZPH2-1|A0AAF6ZPH2_BOVIN Computationally mapped isoform of R3H domain containing 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=4 SV=1 CANONICAL=Q2KIL7-1" }, "locus": { "chromosome": "7", "start_pos": 43443796, "end_pos": 43440273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065311.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065311.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054872.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054872.2" } ] } }, { "isoform_ac": "Q2KIL7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7/entry#Q2KIL7-1", "sequence": { "sequence": "MVVLENPEAGPEEAAAAARVVPGGRRTLPLPGCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGATPGPEDGDLAPPAAPGIFAEACSNETYVEIWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPTRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAICQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 272, "header": "sp|Q2KIL7-1|R3HD4_BOVIN Isoform 1 of R3H domain-containing protein 4 OS=Bos taurus OX=9913 GN=R3HDM4 PE=2 SV=1 CANONICAL=Q2KIL7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 93, "start_aa": "Thr", "end_pos": 93, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr93", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614948", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614948", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJ77-1", "protein_name": "R3H domain containing 4", "gene_name": "R3HDM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVALENPEGGPEVAAAAAGVSPGGRRTLPLPGCLPALASSQVKRLSASKRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETEGGTPGLEDGDLAPPAAPGIFAEACSNETYIEVWNDFMNRSGEEQERVLRYLEDEGKSKARRRGPGRGEDRRREDPAYTPRECFQRISRRLRAILKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQRS", "length": 272 }, "evidence": [ { "id": "Q2KIL7", "url": "https://omabrowser.org/oma/group/Q2KIL7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QMK1-1", "protein_name": "R3H domain-containing protein 4", "gene_name": "R3hdm4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVALDDPDGGPEATPGAEARLPLPGCLPTLGGSQVKRVSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTRYLLTLLETAGGPPGLEDGDLTPPAAPGIFAEACSNATYVEVWNDFMNRSGEEQERVLRYLEDEGQGKRRPGRGPGRGEDRRREDPAFTPHECFRRISRRLRSVLKRSRIPMETLESWEERLLAFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGRRQMKVSNRHLDFLPPELLLSAYLDQQ", "length": 265 }, "evidence": [ { "id": "Q2KIL7", "url": "https://omabrowser.org/oma/group/Q2KIL7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4VBF2-1", "protein_name": "R3H domain-containing protein 4", "gene_name": "R3hdm4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVALDNSEGGPEATPSGETRLSLPGCLPPLSGSQVKRVSASRRKQHFINQAVRNSDLVPRAKGRKSLQRLENTQYLLTLLETAGGPPGVEDGDLTPAAPGIFAEACSNATYVEVWNDFMNRSGEEQERVLRYLEDESQGKRRRGPGRGEDRRREDPVFTPHECFRRISRRLRSVLKRSRIPMETLESWEERLLAFFSVSPQAVYTAMLDNSYERLLLHAVCQYMDLISASADLEGRRQMKVSNRHLDFLPPELLLSAYLDQQ", "length": 262 }, "evidence": [ { "id": "Q2KIL7", "url": "https://omabrowser.org/oma/group/Q2KIL7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96D70-1", "protein_name": "R3H domain-containing protein 4", "gene_name": "R3HDM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVALENPECGPEAAEGTPGGRRLLPLPSCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDGDLAPPASPGIFAEACNNATYVEVWNDFMNRSGEEQERVLRYLEDEGRSKARRRGPGRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQHS", "length": 268 }, "evidence": [ { "id": "Q2KIL7", "url": "https://omabrowser.org/oma/group/Q2KIL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL7", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL7", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIL7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 272, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIL7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIL7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL7" }, { "id": "PRU00382", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "R3H", "eco_id": "ECO_0000255", "start_pos": 191, "end_pos": 254, "start_aa": "Met", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 93 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 128, "end_pos": 130 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T144-1", "uniprot_ac": "Q3T144", "uniprot_id": "T106C_BOVIN", "mass": { "chemical_mass": 27869.0, "monoisotopic_mass": 27869.0 }, "refseq": { "ac": "NP_001029633", "name": "transmembrane protein 106C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029633" }, "gene_names": [ { "name": "TMEM106C", "type": "recommended", "evidence": [ { "id": "Q3T144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T144" } ] }, { "name": "TMEM106C", "type": "synonym", "evidence": [ { "id": "NP_001029633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029633" } ] } ], "protein_names": [ { "name": "Transmembrane protein 106C", "type": "recommended", "evidence": [ { "id": "Q3T144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T144/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 106C", "type": "synonym", "evidence": [ { "id": "NP_001029633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029633" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T144", "url": "https://www.uniprot.org/uniprotkb/Q3T144" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM106C", "url": "https://www.uniprot.org/uniprotkb/Q3T144", "locus": { "chromosome": "5", "start_pos": 32317955, "end_pos": 32323781, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000454", "url": "https://www.ensembl.org/id/ENSBTAG00000000454" } ] } } ], "crossref": [ { "id": "Q3T144", "url": "https://alphafold.ebi.ac.uk/entry/Q3T144", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000454", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000454", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514271", "url": "https://www.ncbi.nlm.nih.gov/gene/514271", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514271", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514271", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYVYAFC", "url": "https://omabrowser.org/oma/group/PYVYAFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJG9", "url": "https://www.orthodb.org/?gene=A0A3Q1LJG9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T144", "url": "https://www.orthodb.org/?gene=Q3T144", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029633", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T144", "url": "https://www.uniprot.org/uniprotkb/Q3T144", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T144-1", "url": "https://www.uniprot.org/uniprotkb/Q3T144-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRHSTYAHRPFSKRRKADDTEDSLAEREQQEAIAQFPYVEFTGRDSITCLTCQGTGYIPEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFDEQRSLVILAITATLKIRNSNFYSVAVTSLSSEVQYMNTVVGSYTTTNISLIPPRSEHLVNFTAKAEMGGPYSYVYFFCTLPYIGVHNVVVFVRTSVKISYIGHVTQSSLETHHYVDCGVNSTAV", "length": 249, "header": "sp|Q3T144-1|T106C_BOVIN Isoform 1 of Transmembrane protein 106C OS=Bos taurus OX=9913 GN=TMEM106C PE=2 SV=1 CANONICAL=Q3T144-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJG9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T144/entry#A0A3Q1LJG9-1", "sequence": { "sequence": "MGSRHSTYAHRPFSKRRKADDTEDSLAEREQQEAIAQFPYVEFTGRDSITCLTCQGTGYIPEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFDEQRSLVILAITATLKIRNSNFYSVAVTSLSSEVQYMNTVVGSYTTTNISLIPPRSEHLVNFTAKAEMGGPYSYVYFFCTLPYIGVHNVVVFVRFLFPRTSVKISYIGHVTQSSLETHHYVDCGVNSTAV", "length": 254, "header": "tr|A0A3Q1LJG9-1|T106C_BOVIN Computationally mapped isoform of Transmembrane protein 106C OS=Bos taurus OX=9913 GN=TMEM106C PE=2 SV=2 CANONICAL=Q3T144-1" }, "locus": { "chromosome": "5", "start_pos": 32323166, "end_pos": 32318959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082699.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082699.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059566.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059566.2" } ] } }, { "isoform_ac": "A0AAF6YHE8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T144/entry#A0AAF6YHE8-1", "sequence": { "sequence": "MGSRHSTYAHRPFSKRRKADDTEDSLAEREQQEAIAQFPYVEFTGRDSITCLTCQGTGYIPGESLVIMVKDDSPRRMKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFDEQRSLVILAITATLKIRNSNFYSVAVTSLSSEVQYMNTVVGSYTTTNISLIPPRSEHLVNFTAKAEMGGPYSYVYFFCTLPYIGVHNVVVFVRTSVKISYIGHVTQSSLETHHYVDCGVNSTAV", "length": 243, "header": "tr|A0AAF6YHE8-1|A0AAF6YHE8_BOVIN Computationally mapped isoform of Transmembrane protein 106C OS=Bos taurus OX=9913 GN=TMEM106C PE=3 SV=1 CANONICAL=Q3T144-1" }, "locus": { "chromosome": "5", "start_pos": 32323166, "end_pos": 32318959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000578.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000578.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000578.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000578.4" } ] } }, { "isoform_ac": "Q3T144-1", "url": "https://www.uniprot.org/uniprotkb/Q3T144/entry#Q3T144-1", "sequence": { "sequence": "MGSRHSTYAHRPFSKRRKADDTEDSLAEREQQEAIAQFPYVEFTGRDSITCLTCQGTGYIPEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFDEQRSLVILAITATLKIRNSNFYSVAVTSLSSEVQYMNTVVGSYTTTNISLIPPRSEHLVNFTAKAEMGGPYSYVYFFCTLPYIGVHNVVVFVRTSVKISYIGHVTQSSLETHHYVDCGVNSTAV", "length": 249, "header": "sp|Q3T144-1|T106C_BOVIN Isoform 1 of Transmembrane protein 106C OS=Bos taurus OX=9913 GN=TMEM106C PE=2 SV=1 CANONICAL=Q3T144-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514271", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514271", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TMU3-1", "protein_name": "Transmembrane protein 106C", "gene_name": "TMEM106C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSQHSAFAHPPSCKRRKADDRENFLAEREQEEAIAQFPYVEFTGRDSITCLTCQGTGYIPTEQVNELVALIPHSDQRLRPQRTKQYVLLSVLLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFNKQDSLVILAITATLKIRNSNFYPVAVTSLSSQVQYMNTVVGSYLTSNVSLIPPRSEHLVNFTAKAEMGGPFSYVYFFCTLPDILVHNIVVFMRTSVKISYIGHMTQSSLETHHYVDCGANSTAV", "length": 250 }, "evidence": [ { "id": "Q3T144", "url": "https://omabrowser.org/oma/group/Q3T144/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80VP8-1", "protein_name": "Transmembrane protein 106C", "gene_name": "Tmem106c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQHSSALTFCQRKKDDNPEDLLADRDQEEAIAQFPYVEFTGRNSITCHTCQGAGYIPAEQVNELVALIPHSDQRLRPQRTKQYVLLSVLLCLLASGLVFFFLFPHSVLVDDNGIKVTKVTFNEQDSLVVLDVTATLKIRNSNFYPVAVTNLFSQVQYMKAVVGSYTTTNVSLIAPRSEHLVNFTVKAEVGGPSSYVYFYCTLPAIRVHNIVIFMRTSVKISYIGHISQSTLETQHYVDCGVNSTAAQSLFLVPRGPHL", "length": 260 }, "evidence": [ { "id": "Q3T144", "url": "https://omabrowser.org/oma/group/Q3T144/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BVX2-1", "protein_name": "Transmembrane protein 106C", "gene_name": "TMEM106C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSQHSAAARPSSCRRKQEDDRDGLLAEREQEEAIAQFPYVEFTGRDSITCLTCQGTGYIPTEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFNKQDSLVILTIMATLKIRNSNFYTVAVTSLSSQIQYMNTVVSTYVTTNVSLIPPRSEQLVNFTGKAEMGGPFSYVYFFCTVPEILVHNIVIFMRTSVKISYIGLMTQSSLETHHYVDCGGNSTAI", "length": 250 }, "evidence": [ { "id": "Q3T144", "url": "https://omabrowser.org/oma/group/Q3T144/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T144", "url": "https://www.uniprot.org/uniprotkb/Q3T144" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q3T144", "url": "https://www.uniprot.org/uniprotkb/Q3T144" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T144-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T144-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T144" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DU0-1", "uniprot_ac": "Q58DU0", "uniprot_id": "MMTA2_BOVIN", "mass": { "chemical_mass": 26211.0, "monoisotopic_mass": 26211.0 }, "refseq": { "ac": "NP_001029444", "name": "multiple myeloma tumor-associated protein 2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" }, "gene_names": [ { "name": "C7H1orf35", "type": "recommended", "evidence": [ { "id": "Q58DU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ] }, { "name": "MMTAG2", "type": "recommended", "evidence": [ { "id": "Q58DU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ] }, { "name": "C1orf35", "type": "synonym", "evidence": [ { "id": "NP_001029444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" } ] }, { "name": "C7H1orf35", "type": "synonym", "evidence": [ { "id": "NP_001029444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" } ] }, { "name": "MMTAG2", "type": "synonym", "evidence": [ { "id": "NP_001029444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" } ] } ], "protein_names": [ { "name": "Multiple myeloma tumor-associated protein 2 homolog", "type": "recommended", "evidence": [ { "id": "Q58DU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU0/entry#names_and_taxonomy" } ] }, { "name": "multiple myeloma transforming gene 2", "type": "synonym", "evidence": [ { "id": "NP_001029444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" } ] }, { "name": "multiple myeloma tumor-associated protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DU0", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MMTAG2", "url": "https://www.uniprot.org/uniprotkb/Q58DU0", "locus": {} } ], "crossref": [ { "id": "Q58DU0", "url": "https://alphafold.ebi.ac.uk/entry/Q58DU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020720", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020720", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506656", "url": "https://www.ncbi.nlm.nih.gov/gene/506656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506656", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506656", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DU0", "url": "https://www.orthodb.org/?gene=Q58DU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14580", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14580", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14580:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14580:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJU9", "url": "https://www.uniprot.org/uniprotkb/A0A452DJU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJU9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DU0", "url": "https://www.uniprot.org/uniprotkb/Q58DU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DU0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGSSRGGVRGGQDQFSWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRANSAGLSREQELAAVRQAEQEALMAALGYKNVKKQPTGLSKEDFVEVCKREGGDPEKGVDRLLGLGSSSGSVGRVALSREDKEAAKLGLSVFTHHRVESSRPGTSLALAKKKLRSEEKVEPGPESHRKSRKEKKKKRHKKEKRKKEKDRGRRLDSSLAPAPIQHDSDSSTCCKKRRHDSD", "length": 235, "header": "sp|Q58DU0-1|MMTA2_BOVIN Isoform 1 of Multiple myeloma tumor-associated protein 2 homolog OS=Bos taurus OX=9913 GN=MMTAG2 PE=2 SV=1 CANONICAL=Q58DU0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPS7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU0/entry#A0A3Q1LPS7-1", "sequence": { "sequence": "MLCRVSVQALWLGRPGREGGECASARGWRGSDVTVCDAGVGAGTCRALVLGIPGRGLHVTAMFGSSRGGVRGGQDQFSWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRANSAGLSREQELAAVRQAEQEALMAALGYKNVKKQPTGLSKEDFVEVCKREGGDPEKGVDRLLGLGSSSGSVGRVALSREDKEAAKLGLSVFTHHRVESSRPGTSLALAKKKLRSEEKVEPGPESHRKSRKEKKKKRHKKEKRKKEKDRGRRLDSSLAPAPIQHLVVSLGMTLTLQLAARSAGTTVTEAQGVWRTGLWGLPQAPREA", "length": 323, "header": "tr|A0A3Q1LPS7-1|MMTA2_BOVIN Computationally mapped isoform of Multiple myeloma tumor-associated protein 2 homolog OS=Bos taurus OX=9913 GN=MMTAG2 PE=2 SV=2 CANONICAL=Q58DU0-1" }, "locus": { "chromosome": "7", "start_pos": 3000077, "end_pos": 2997893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056969.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056969.2" } ] } }, { "isoform_ac": "A0A452DJU9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU0/entry#A0A452DJU9-1", "sequence": { "sequence": "MFGSSRGGVRGGQDQFSWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRANSAGLSREQELAAVRQAEQEALMAALGYKNVKKQPTGLSKEDFVEVCKREGGDPEKGVDRLLGLGSSRCGAGGGVLGSPRNREGAASWGLHHRVESSRPGTSLALAKKKLRSEEKVEPGPESHRKSRKEKKKKRHKKEKRKKEKDRGRRLDSSLAPAPIQHDSDSSTCCKKRRHDSD", "length": 233, "header": "tr|A0A452DJU9-1|A0A452DJU9_BOVIN Computationally mapped isoform of Chromosome 7 C1orf35 homolog OS=Bos taurus OX=9913 GN=C7H1orf35 PE=4 SV=1 CANONICAL=Q58DU0-1" }, "locus": { "chromosome": "7", "start_pos": 3000016, "end_pos": 2998076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027612.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027612.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027612.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027612.4" } ] } }, { "isoform_ac": "Q58DU0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU0/entry#Q58DU0-1", "sequence": { "sequence": "MFGSSRGGVRGGQDQFSWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRANSAGLSREQELAAVRQAEQEALMAALGYKNVKKQPTGLSKEDFVEVCKREGGDPEKGVDRLLGLGSSSGSVGRVALSREDKEAAKLGLSVFTHHRVESSRPGTSLALAKKKLRSEEKVEPGPESHRKSRKEKKKKRHKKEKRKKEKDRGRRLDSSLAPAPIQHDSDSSTCCKKRRHDSD", "length": 235, "header": "sp|Q58DU0-1|MMTA2_BOVIN Isoform 1 of Multiple myeloma tumor-associated protein 2 homolog OS=Bos taurus OX=9913 GN=MMTAG2 PE=2 SV=1 CANONICAL=Q58DU0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DU0", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ], "site_lbl": "Ser122" }, { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DU0", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ], "site_lbl": "Ser126" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DU0", "url": "https://www.uniprot.org/uniprotkb/Q58DU0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506656", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506656", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DU0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DU0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DU0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 122, 126 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T033-1", "uniprot_ac": "Q3T033", "uniprot_id": "MSPD3_BOVIN", "mass": { "chemical_mass": 25654.0, "monoisotopic_mass": 25654.0 }, "refseq": { "ac": "NP_001029437", "name": "motile sperm domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029437" }, "gene_names": [ { "name": "MOSPD3", "type": "recommended", "evidence": [ { "id": "Q3T033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T033" } ] }, { "name": "MOSPD3", "type": "synonym", "evidence": [ { "id": "NP_001029437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029437" } ] } ], "protein_names": [ { "name": "Motile sperm domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q3T033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#names_and_taxonomy" } ] }, { "name": "motile sperm domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029437" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T033", "url": "https://www.uniprot.org/uniprotkb/Q3T033" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOSPD3", "url": "https://www.uniprot.org/uniprotkb/Q3T033", "locus": { "chromosome": "25", "start_pos": 35950041, "end_pos": 35952822, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026246", "url": "https://www.ensembl.org/id/ENSBTAG00000026246" } ] } } ], "crossref": [ { "id": "Q3T033", "url": "https://alphafold.ebi.ac.uk/entry/Q3T033", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026246", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506163", "url": "https://www.ncbi.nlm.nih.gov/gene/506163", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506163", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506163", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQ60", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ60", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ70", "url": "https://www.orthodb.org/?gene=A0A452DJ70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T033", "url": "https://www.orthodb.org/?gene=Q3T033", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34441", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34441", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34441:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34441:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00635", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00635", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029437", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ60-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ70", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ70-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T033", "url": "https://www.uniprot.org/uniprotkb/Q3T033", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T033-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRGAPQDQELVGPGAPGRGSRGAPPPSGPVVPVLVFPPDLVFRADQRSGPRQLLTLYNPTGAVLRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPENPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLGLLTMVFLRT", "length": 235, "header": "sp|Q3T033-1|MSPD3_BOVIN Isoform 1 of Motile sperm domain-containing protein 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=2 SV=1 CANONICAL=Q3T033-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ60-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#A0A3Q1LQ60-1", "sequence": { "sequence": "MRRGAPQDQELVGPGAPGRGSRGAPPPSGPVVPVLVFPPDLVFRADQRSGPRQLLTLYNPTGAVLRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPERVEAGALDSPCSPDPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLGLLTMVFLRT", "length": 248, "header": "tr|A0A3Q1LQ60-1|MSPD3_BOVIN Computationally mapped isoform of Motile sperm domain-containing protein 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=2 SV=3 CANONICAL=Q3T033-1" }, "locus": { "chromosome": "25", "start_pos": 35952291, "end_pos": 35950320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067520.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067520.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062287.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062287.3" } ] } }, { "isoform_ac": "A0A452DJ70-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#A0A452DJ70-1", "sequence": { "sequence": "MRRGAPQDQELVGPGAPGRGSRGAPPPSGPVVPVLVFPPDLVFRADQRSGPRQLLTLYNPTGAVLFFPTLCLVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPENPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLETRPHLPMSFLQFLLLPPRGPLRI", "length": 227, "header": "tr|A0A452DJ70-1|A0A452DJ70_BOVIN Computationally mapped isoform of Motile sperm domain containing 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=4 SV=2 CANONICAL=Q3T033-1" }, "locus": { "chromosome": "25", "start_pos": 35952291, "end_pos": 35950044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037226.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037226.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037064.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037064.5" } ] } }, { "isoform_ac": "A0AAA9S7J2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#A0AAA9S7J2-1", "sequence": { "sequence": "GDPGPCWGRRVWGTWAWSAGGALSSGVLRRRRRRNHPTPCFTVSSRSLRPSHPSALYSRPRPLSSALGCSTAQSLHAPWGAPGPGAVFRADQRSGPRQLLTLYNPTGAVLRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPENPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLGLLTMVFLRT", "length": 280, "header": "tr|A0AAA9S7J2-1|A0AAA9S7J2_BOVIN Computationally mapped isoform of Motile sperm domain-containing protein 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=4 SV=1 CANONICAL=Q3T033-1" }, "locus": { "chromosome": "25", "start_pos": 35952517, "end_pos": 35950320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078129.1" } ] } }, { "isoform_ac": "A0AAA9SF43-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#A0AAA9SF43-1", "sequence": { "sequence": "GDPGPCWGRRVWGTWAWSAGGALSSGVLRRRRRRNHPTPCFTVSSRSLRPSHPSALYSRPRPLSSALGCSTAQSLHAPWGAPGPGAVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPENPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLGLLTMVFLRT", "length": 253, "header": "tr|A0AAA9SF43-1|A0AAA9SF43_BOVIN Computationally mapped isoform of Motile sperm domain containing 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=4 SV=1 CANONICAL=Q3T033-1" }, "locus": { "chromosome": "25", "start_pos": 35952517, "end_pos": 35950320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115607.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115607.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084002.1" } ] } }, { "isoform_ac": "Q3T033-1", "url": "https://www.uniprot.org/uniprotkb/Q3T033/entry#Q3T033-1", "sequence": { "sequence": "MRRGAPQDQELVGPGAPGRGSRGAPPPSGPVVPVLVFPPDLVFRADQRSGPRQLLTLYNPTGAVLRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPHPRNYDVQDRFRIELSEEGTEGRVVGRKDITSVLRAPAYPLELQGQSDPTPHPEPHSWTASSTAQPFPENPHPQLATSSFLLFLLMGTVSVAFLLLPLQDELGSQLPQILHVSLGQKLVAAYVLGLLTMVFLRT", "length": 235, "header": "sp|Q3T033-1|MSPD3_BOVIN Isoform 1 of Motile sperm domain-containing protein 3 OS=Bos taurus OX=9913 GN=MOSPD3 PE=2 SV=1 CANONICAL=Q3T033-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506163", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506163", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T033", "url": "https://www.uniprot.org/uniprotkb/Q3T033" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T033-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T033-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T033" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T033" }, { "id": "PRU00132", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MSP", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 145, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CU3-1", "uniprot_ac": "Q58CU3", "uniprot_id": "HBAP1_BOVIN", "mass": { "chemical_mass": 54882.0, "monoisotopic_mass": 54882.0 }, "refseq": { "ac": "NP_001014911", "name": "HSPB1-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911" }, "gene_names": [ { "name": "HSPBAP1", "type": "recommended", "evidence": [ { "id": "Q58CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" } ] }, { "name": "HSPBAP1", "type": "synonym", "evidence": [ { "id": "NP_001014911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911" } ] } ], "protein_names": [ { "name": "HSPB1-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q58CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#names_and_taxonomy" } ] }, { "name": "27 KdA heat shock protein-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911" } ] }, { "name": "27 kDa heat shock protein-associated protein 1", "type": "synonym", "evidence": [ { "id": "Q58CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#names_and_taxonomy" } ] }, { "name": "HSPB1-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911" } ] }, { "name": "Hspb associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911" } ] } ], "function": [ { "annotation": "May play a role in cellular stress response.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQU6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU6#function" }, { "database": "UniProtKB", "id": "ARBA00037342", "url": "https://www.uniprot.org/uniprotkb/ARBA00037342#function" }, { "database": "UniProtKB", "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3#function" }, { "database": "UniProtKB", "id": "A0AAA9RSN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSN2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MKN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKN1#function" }, { "database": "UniProtKB", "id": "A0AAA9SRK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK4#function" }, { "database": "UniProtKB", "id": "A0AAA9TAL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL2#function" }, { "database": "UniProtKB", "id": "A0AAA9TUM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPBAP1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3", "locus": { "chromosome": "1", "start_pos": 67051022, "end_pos": 67121314, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005066", "url": "https://www.ensembl.org/id/ENSBTAG00000005066" } ] } } ], "crossref": [ { "id": "Q58CU3", "url": "https://alphafold.ebi.ac.uk/entry/Q58CU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005066", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005066", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513211", "url": "https://www.ncbi.nlm.nih.gov/gene/513211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041667", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513211", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513211", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQU6", "url": "https://www.orthodb.org/?gene=A0A3Q1LQU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MKN1", "url": "https://www.orthodb.org/?gene=A0A3Q1MKN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CU3", "url": "https://www.orthodb.org/?gene=Q58CU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12461:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014911", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQU6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQU6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CU3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CU3-2", "url": "https://www.uniprot.org/uniprotkb/Q58CU3-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARPGAITNADSASGGGEEEGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 484, "header": "sp|Q58CU3-1|HBAP1_BOVIN Isoform 1 of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=2 SV=1 CANONICAL=Q58CU3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQU6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0A3Q1LQU6-1", "sequence": { "sequence": "CARKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 456, "header": "tr|A0A3Q1LQU6-1|HBAP1_BOVIN Computationally mapped isoform of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=2 SV=2 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67101358, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057387.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057387.2" } ] } }, { "isoform_ac": "A0A3Q1MKN1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0A3Q1MKN1-1", "sequence": { "sequence": "MAARPGAITNADSASGGGEEEGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQCAQVS", "length": 474, "header": "tr|A0A3Q1MKN1-1|A0A3Q1MKN1_BOVIN Computationally mapped isoform of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=4 SV=2 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67120159, "end_pos": 67051090, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081894.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081894.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072121.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072121.2" } ] } }, { "isoform_ac": "A0AAA9RSN2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0AAA9RSN2-1", "sequence": { "sequence": "MYPSGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 467, "header": "tr|A0AAA9RSN2-1|A0AAA9RSN2_BOVIN Computationally mapped isoform of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=4 SV=1 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67114649, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123178.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123178.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075657.1" } ] } }, { "isoform_ac": "A0AAA9SRK4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0AAA9SRK4-1", "sequence": { "sequence": "MYSKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 465, "header": "tr|A0AAA9SRK4-1|A0AAA9SRK4_BOVIN Computationally mapped isoform of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=4 SV=1 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67121115, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094680.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094680.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085603.1" } ] } }, { "isoform_ac": "A0AAA9TAL2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0AAA9TAL2-1", "sequence": { "sequence": "MASRYDLGWERKARTQHFTRYWWRSGKELTCQCRRHRFNPWVRKIPLEKEMAIYSSILAWRIPLDREAWREQSVGSQKVVSPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 481, "header": "tr|A0AAA9TAL2-1|A0AAA9TAL2_BOVIN Computationally mapped isoform of HSPB1 associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=4 SV=1 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67100864, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124066.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124066.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093670.1" } ] } }, { "isoform_ac": "A0AAA9TUM6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#A0AAA9TUM6-1", "sequence": { "sequence": "MAARPGAITNADSASGGGEEEAEKAMAPHSSTLAWRIPWTEEPGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 506, "header": "tr|A0AAA9TUM6-1|A0AAA9TUM6_BOVIN Computationally mapped isoform of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=4 SV=1 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67120159, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100279.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100279.1" } ] } }, { "isoform_ac": "Q58CU3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#Q58CU3-1", "sequence": { "sequence": "MAARPGAITNADSASGGGEEEGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTAPQFETACNYVEATLEEFLSWNSDQSSISGAFRDYDHSKFWAYADYKYFVSLFEDKTDIFQDVIWSDFGFPGRNGQESTLWIGSLGAHTPCHLDTYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKARRHMVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHQTRVEEAITRMLVCALKTAENPHNTRAWLNPTELEETSHEINCHYLNGAISAFFNHYGTSEVVETQALRTNREYTIKEELNMHSHVGVEQAGGHNLSSETVKQEAASPFGLDLVPVTPSSEEPSSERGGIFENDGEDFVSKNGKSFGKRQRMMSESENAVVEQIASDRTVAVSQTFVSTDDLLDCLVNPQVTRIVAQLLIQGRST", "length": 484, "header": "sp|Q58CU3-1|HBAP1_BOVIN Isoform 1 of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=2 SV=1 CANONICAL=Q58CU3-1" }, "locus": { "chromosome": "1", "start_pos": 67120159, "end_pos": 67064563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006679.4", "url": "https://www.ensembl.org/id/ENSBTAT00000006679.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006679.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006679.3" } ] } }, { "isoform_ac": "Q58CU3-2", "url": "https://www.uniprot.org/uniprotkb/Q58CU3/entry#Q58CU3-2", "sequence": { "sequence": "MAARPGAITNADSASGGGEEEGKHVKPFTPEKAKEIIMCLQQPAVFYNMVFDWPAQHWTAKHLSEVLHGKQIRFRMGTKSTDTGRTTRNRHRNVSS", "length": 96, "header": "sp|Q58CU3-2|HBAP1_BOVIN Isoform 2 of HSPB1-associated protein 1 OS=Bos taurus OX=9913 GN=HSPBAP1 PE=2 SV=1 CANONICAL=Q58CU3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513211", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513211", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "database": "UniProtKB", "id": "Q58CU3", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 484, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CU3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU3" }, { "id": "PRU00538", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00538" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "JmjC", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 288, "start_aa": "Trp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 374, "end_pos": 376 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIJ9-1", "uniprot_ac": "Q2KIJ9", "uniprot_id": "TCAL1_BOVIN", "mass": { "chemical_mass": 18650.0, "monoisotopic_mass": 18650.0 }, "refseq": { "ac": "NP_001039425", "name": "transcription elongation factor A protein-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" }, "gene_names": [ { "name": "TCEAL1", "type": "recommended", "evidence": [ { "id": "Q2KIJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9" } ] }, { "name": "TCEAL1", "type": "synonym", "evidence": [ { "id": "NP_001039425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" } ] } ], "protein_names": [ { "name": "Transcription elongation factor A protein-like 1", "type": "recommended", "evidence": [ { "id": "Q2KIJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#names_and_taxonomy" } ] }, { "name": "TCEA-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" }, { "id": "Q2KIJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#names_and_taxonomy" } ] }, { "name": "Transcription elongation factor S-II protein-like 1", "type": "synonym", "evidence": [ { "id": "Q2KIJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#names_and_taxonomy" } ] }, { "name": "transcription elongation factor A (SII)-like 1", "type": "synonym", "evidence": [ { "id": "NP_001039425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" } ] }, { "name": "transcription elongation factor A protein-like 1", "type": "synonym", "evidence": [ { "id": "NP_001039425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" } ] }, { "name": "transcription elongation factor S-II protein-like 1", "type": "synonym", "evidence": [ { "id": "NP_001039425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCEAL1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9", "locus": { "chromosome": "X", "start_pos": 52397109, "end_pos": 52393725, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049730", "url": "https://www.ensembl.org/id/ENSBTAG00000049730" } ] } } ], "crossref": [ { "id": "Q2KIJ9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049730", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507187", "url": "https://www.ncbi.nlm.nih.gov/gene/507187", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507187", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507187", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HWKAKRN", "url": "https://omabrowser.org/oma/group/HWKAKRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSQ2", "url": "https://www.orthodb.org/?gene=A0A3Q1LSQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7K7", "url": "https://www.orthodb.org/?gene=A0A3Q1N7K7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIJ9", "url": "https://www.orthodb.org/?gene=Q2KIJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF04538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSQ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7K7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7K7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7K7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIJ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKACKEPEEQPQSPPKADEERPSVEPSPEKSSPEEQSSEEVSSEEEFFPDELLPELLPEMLESEERPPQERLSRKDLFEARPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIKVAEEMEEMKRVRNKLMVMHWKARRNRPYPI", "length": 159, "header": "sp|Q2KIJ9-1|TCAL1_BOVIN Isoform 1 of Transcription elongation factor A protein-like 1 OS=Bos taurus OX=9913 GN=TCEAL1 PE=2 SV=1 CANONICAL=Q2KIJ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#A0A3Q1LSQ2-1", "sequence": { "sequence": "MLTVSSNQQKAHINKREPVSAQVLLVLVLFACPDTICLSPFGRGEKQKKTILNMEKACKEPEEQPQSPPKADEERPSVEPSPEKSSPEEQSSEEVSSEEEFFPDELLPELLPEMLESEERPPQERLSRKDLFEARPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIKVAEEMEEMKRVRNKLMVMHWKARRNRPYPI", "length": 212, "header": "tr|A0A3Q1LSQ2-1|A0A3Q1LSQ2_BOVIN Computationally mapped isoform of Transcription elongation factor A like 1 OS=Bos taurus OX=9913 GN=TCEAL1 PE=4 SV=2 CANONICAL=Q2KIJ9-1" }, "locus": { "chromosome": "X", "start_pos": 52395671, "end_pos": 52395195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126514.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126514.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097636.1" } ] } }, { "isoform_ac": "A0A3Q1N7K7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#A0A3Q1N7K7-1", "sequence": { "sequence": "MSSVSGIKKYRLVAAARPPVRVVTGDLSSAVTRGPHVTRARVCPSPSRPGPFCLSRHHMPIALWTRGKAEETILNMEKACKEPEEQPQSPPKADEERPSVEPSPEKSSPEEQSSEEVSSEEEFFPDELLPELLPEMLESEERPPQERLSRKDLFEARPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIKVAEEMEEMKRVRNKLMVMHWKARRNRPYPI", "length": 234, "header": "tr|A0A3Q1N7K7-1|A0A3Q1N7K7_BOVIN Computationally mapped isoform of Transcription elongation factor A like 1 OS=Bos taurus OX=9913 GN=TCEAL1 PE=4 SV=1 CANONICAL=Q2KIJ9-1" }, "locus": { "chromosome": "X", "start_pos": 52395671, "end_pos": 52395195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076246.1", "url": "https://www.ensembl.org/id/ENSBTAT00000076246.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066726.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066726.1" } ] } }, { "isoform_ac": "A0AAA9TBB1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#A0AAA9TBB1-1", "sequence": { "sequence": "MSSVSGIKKYRLVAAARPPVRVVTGDLSSAVTRGPHVTRARVCPSPSRPGPFCLSRHHMPIALWTRGKAEEIFPSSPPPTLSRRQSAAPQVTAGHLEERPPRNQPPGETILNMEKACKEPEEQPQSPPKADEERPSVEPSPEKSSPEEQSSEEVSSEEEFFPDELLPELLPEMLESEERPPQERLSRKDLFEARPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIKVAEEMEEMKRVRNKLMVMHWKARRNRPYPI", "length": 271, "header": "tr|A0AAA9TBB1-1|A0AAA9TBB1_BOVIN Computationally mapped isoform of Transcription elongation factor A like 1 OS=Bos taurus OX=9913 GN=TCEAL1 PE=4 SV=1 CANONICAL=Q2KIJ9-1" }, "locus": { "chromosome": "X", "start_pos": 52395671, "end_pos": 52394111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107362.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107362.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093963.1" } ] } }, { "isoform_ac": "Q2KIJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9/entry#Q2KIJ9-1", "sequence": { "sequence": "MEKACKEPEEQPQSPPKADEERPSVEPSPEKSSPEEQSSEEVSSEEEFFPDELLPELLPEMLESEERPPQERLSRKDLFEARPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIKVAEEMEEMKRVRNKLMVMHWKARRNRPYPI", "length": 159, "header": "sp|Q2KIJ9-1|TCAL1_BOVIN Isoform 1 of Transcription elongation factor A protein-like 1 OS=Bos taurus OX=9913 GN=TCEAL1 PE=2 SV=1 CANONICAL=Q2KIJ9-1" }, "locus": { "chromosome": "X", "start_pos": 52395671, "end_pos": 52395195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091895.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091895.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507187", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507187", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HW25-1", "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "Tceal1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MENSCKGNEEQTQSTLKTDEEQPPVEQYPENQCSEEEQSSEDLSSEEQSSEEEFFPEELLPELLPEMLLSEDRPPQECLSEKNLFEDRPPMEQPPCGVGKHKLEEGSFKERLALFRPRFRGEIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI", "length": 165 }, "evidence": [ { "id": "Q2KIJ9", "url": "https://omabrowser.org/oma/group/Q2KIJ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q15170-1", "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "TCEAL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDKPRKENEEEPQSAPKTDEERPPVEHSPEKQSPEEQSSEEQSSEEEFFPEELLPELLPEMLLSEERPPQEGLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI", "length": 159 }, "evidence": [ { "id": "Q2KIJ9", "url": "https://omabrowser.org/oma/group/Q2KIJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PPP3-1", "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "Tceal1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MENSHNESEEQPQSTPKVEEEQPAVEQSPENQCSEDDQSSEDLSSEEQSSDEEFFPEELLPELLPEMLLCEDRPPQECLPQKNAFEDRIPMEQPPCGIGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIRAADELEEMKRVRNKLMIMHWKAKRSRPYPI", "length": 165 }, "evidence": [ { "id": "Q2KIJ9", "url": "https://omabrowser.org/oma/group/Q2KIJ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q921P9-1", "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "Tceal1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENTRSENEEQPESTLKIDEEQPAVEQSPENQCSEEDQSSEDLSSEEQSSEEEFFPEELLPELLPEMLLSEDRPPQECLSQKNQFEDRIPMEQPPCGVGKHKLEEGSFKERLARIRPQFIGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI", "length": 165 }, "evidence": [ { "id": "Q2KIJ9", "url": "https://omabrowser.org/oma/group/Q2KIJ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2KIJ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIJ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA20-1", "uniprot_ac": "Q2TA20", "uniprot_id": "SPT22_BOVIN", "mass": { "chemical_mass": 41472.0, "monoisotopic_mass": 41472.0 }, "refseq": { "ac": "NP_001033275", "name": "spermatogenesis-associated protein 22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033275" }, "gene_names": [ { "name": "SPATA22", "type": "recommended", "evidence": [ { "id": "Q2TA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ] }, { "name": "SPATA22", "type": "synonym", "evidence": [ { "id": "NP_001033275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033275" } ] } ], "protein_names": [ { "name": "Spermatogenesis-associated protein 22", "type": "recommended", "evidence": [ { "id": "Q2TA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 22", "type": "synonym", "evidence": [ { "id": "NP_001033275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033275" } ] } ], "function": [ { "annotation": "Meiosis-specific protein required for homologous recombination in meiosis I.", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20#function" }, { "database": "UniProtKB", "id": "Q5SV06", "url": "https://www.uniprot.org/uniprotkb/Q5SV06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA22", "url": "https://www.uniprot.org/uniprotkb/Q2TA20", "locus": { "chromosome": "19", "start_pos": 24190814, "end_pos": 24212643, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015763", "url": "https://www.ensembl.org/id/ENSBTAG00000015763" } ] } } ], "crossref": [ { "id": "Q2TA20", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015763", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015763", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539692", "url": "https://www.ncbi.nlm.nih.gov/gene/539692", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539692", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539692", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDHSPAY", "url": "https://omabrowser.org/oma/group/QDHSPAY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LST4", "url": "https://www.orthodb.org/?gene=A0A3Q1LST4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TA20", "url": "https://www.orthodb.org/?gene=Q2TA20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35258:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35258:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001033275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033275", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LST4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LST4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LST4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LST4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA20-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRNLNENSTRSTAGCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFKCVSVRPASASEQKTFQAFVKIVDAEMRYYTSVMNEV", "length": 364, "header": "sp|Q2TA20-1|SPT22_BOVIN Isoform 1 of Spermatogenesis-associated protein 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=2 SV=1 CANONICAL=Q2TA20-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LST4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#A0A3Q1LST4-1", "sequence": { "sequence": "MKRNLNENSTRSTAGCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIVFNGHHHFLLKILNTEHDRKKSNYCLRVPPPGPAH", "length": 336, "header": "tr|A0A3Q1LST4-1|A0A3Q1LST4_BOVIN Computationally mapped isoform of Spermatosis associated 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=4 SV=2 CANONICAL=Q2TA20-1" }, "locus": { "chromosome": "19", "start_pos": 24211135, "end_pos": 24190859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066501.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066501.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060337.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060337.2" } ] } }, { "isoform_ac": "A0AAA9RZH8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#A0AAA9RZH8-1", "sequence": { "sequence": "MKRNLNENSTRSTADWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFKCVSVRPASASEQKTFQAFVKIVDAEMRYYTSVMNEV", "length": 320, "header": "tr|A0AAA9RZH8-1|A0AAA9RZH8_BOVIN Computationally mapped isoform of Spermatosis associated 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=4 SV=1 CANONICAL=Q2TA20-1" }, "locus": { "chromosome": "19", "start_pos": 24211135, "end_pos": 24197915, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076741.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076741.1" } ] } }, { "isoform_ac": "A0AAA9SLV7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#A0AAA9SLV7-1", "sequence": { "sequence": "MKRNLNENSTRSTAGCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILGS", "length": 269, "header": "tr|A0AAA9SLV7-1|A0AAA9SLV7_BOVIN Computationally mapped isoform of Spermatosis associated 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=4 SV=1 CANONICAL=Q2TA20-1" }, "locus": { "chromosome": "19", "start_pos": 24211135, "end_pos": 24198099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084882.1" } ] } }, { "isoform_ac": "A0AAA9TJJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#A0AAA9TJJ5-1", "sequence": { "sequence": "IKRNPNLYKYICCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFKCVSVRPASASEQKTFQAFVKIVDAEMRYYTSVMNEV", "length": 361, "header": "tr|A0AAA9TJJ5-1|A0AAA9TJJ5_BOVIN Computationally mapped isoform of Spermatosis associated 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=4 SV=1 CANONICAL=Q2TA20-1" }, "locus": { "chromosome": "19", "start_pos": 24210207, "end_pos": 24197915, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102212.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102212.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098513.1" } ] } }, { "isoform_ac": "Q2TA20-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA20/entry#Q2TA20-1", "sequence": { "sequence": "MKRNLNENSTRSTAGCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFKCVSVRPASASEQKTFQAFVKIVDAEMRYYTSVMNEV", "length": 364, "header": "sp|Q2TA20-1|SPT22_BOVIN Isoform 1 of Spermatogenesis-associated protein 22 OS=Bos taurus OX=9913 GN=SPATA22 PE=2 SV=1 CANONICAL=Q2TA20-1" }, "locus": { "chromosome": "19", "start_pos": 24211135, "end_pos": 24197915, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020932.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020932.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020932.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020932.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539692", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539692", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5SV06-1", "protein_name": "Spermatogenesis-associated protein 22", "gene_name": "Spata22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRNLNESSARSTAGCLPVPLFNQKKRNRQPLTSNPLQNDPGVSTVSDSYGSPSFPTDWAWEAVNPEVAPLKKTVNTGQIPASASYPWRSQDSVSKSIQSNAERSQSAWGYRGNNRNTSLRTWDFRPQHKTVSPAANSEFSSCPVNLGAQQQKQFQTPEFPNLPGHKEAEVPRQTCLSKLPGSTMKGPDRASALQAFKPSFQQNPFKKTVLGDIPRENSLKEGTLHQLKEKDNSLRIISAVIESMKYWRAHVQKTVLLFEILAVLDSAVTSGPHYSKTFLMRDGKNILPCVFYEIDRELPRLIRGRVHRCVGHYDPDKNIFKCVSVRPASASEQKTFQAFVTIADAEMKYHTKVTNEM", "length": 358 }, "evidence": [ { "id": "Q2TA20", "url": "https://omabrowser.org/oma/group/Q2TA20/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NHS9-1", "protein_name": "Spermatogenesis-associated protein 22", "gene_name": "SPATA22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRSLNENSARSTAGCLPVPLFNQKKRNRQPLTSNPLKDDSGISTPSDNYDFPPLPTDWAWEAVNPELAPVMKTVDTGQIPHSVSRPLRSQDSVFNSIQSNTGRSQGGWSYRDGNKNTSLKTWNKNDFKPQCKRTNLVANDGKNSCPVSSGAQQQKQLRIPEPPNLSRNKETELLRQTHSSKISGCTMRGLDKNSALQTLKPNFQQNQYKKQMLDDIPEDNTLKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKNTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFQCVSVRPASVSEQKTFQAFVKIADVEMQYYINVMNET", "length": 363 }, "evidence": [ { "id": "Q2TA20", "url": "https://omabrowser.org/oma/group/Q2TA20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of meiotic cell cycle", "id": "GO:0051445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051445", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "pmid": "" }, { "name": "meiotic DNA repair synthesis", "id": "GO:0000711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000711", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "pmid": "" }, { "name": "gamete generation", "id": "GO:0007276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007276", "evidence": [ { "database": "UniProtKB", "id": "Q2TA20", "url": "https://www.uniprot.org/uniprotkb/Q2TA20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA20-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 364, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA20-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA20" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 45, "end_pos": 47 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKS2-1", "uniprot_ac": "Q2NKS2", "uniprot_id": "COX16_BOVIN", "mass": { "chemical_mass": 12518.0, "monoisotopic_mass": 12518.0 }, "refseq": { "ac": "NP_001040033", "name": "cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033" }, "gene_names": [ { "name": "COX16", "type": "recommended", "evidence": [ { "id": "Q2NKS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2" } ] }, { "name": "C10H14ORF112", "type": "synonym", "evidence": [ { "id": "NP_001040033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033" } ] }, { "name": "COX16", "type": "synonym", "evidence": [ { "id": "NP_001040033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2NKS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2/entry#names_and_taxonomy" } ] }, { "name": "COX16, cytochrome c oxidase assembly homolog", "type": "synonym", "evidence": [ { "id": "NP_001040033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033" } ] }, { "name": "cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001040033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033" } ] } ], "function": [ { "annotation": "Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS2", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2#function" }, { "database": "UniProtKB", "id": "Q9P0S2", "url": "https://www.uniprot.org/uniprotkb/Q9P0S2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKS2", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COX16", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2", "locus": { "chromosome": "10", "start_pos": 82060888, "end_pos": 82026168, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030595", "url": "https://www.ensembl.org/id/ENSBTAG00000030595" } ] } } ], "crossref": [ { "id": "Q2NKS2", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615979", "url": "https://www.ncbi.nlm.nih.gov/gene/615979", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615979", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615979", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FKYGVPF", "url": "https://omabrowser.org/oma/group/FKYGVPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKS2", "url": "https://www.orthodb.org/?gene=Q2NKS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17130:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17130:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040033", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKS2", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKS2-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGYAVRRALRKSKTLRYGVPMLLLIVGGSFGLREFSQIRYDAVKIKIDPELEKKLKMNKVSLESEYEKIKDSTFDDWKNIRGPRPWEDPDLLQGRNPEILKTNKTT", "length": 107, "header": "sp|Q2NKS2-1|COX16_BOVIN Isoform 1 of Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Bos taurus OX=9913 GN=COX16 PE=3 SV=1 CANONICAL=Q2NKS2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTS5-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2/entry#A0A3Q1LTS5-1", "sequence": { "sequence": "MSPLRYTPSRTSTTRQRCFYQTYEDANELHIPVHLKLLIVGGSFGLREFSQIRYDAVKIKIDPELEKKLKMNKVSLESEYEKIKDSTFDDWKNIRGPRPWEDPDLLQGRNPEILKTNKTT", "length": 120, "header": "tr|A0A3Q1LTS5-1|A0A3Q1LTS5_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Bos taurus OX=9913 GN=COX16 PE=3 SV=2 CANONICAL=Q2NKS2-1" }, "locus": { "chromosome": "10", "start_pos": 82060625, "end_pos": 82038336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075762.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075762.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060494.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060494.2" } ] } }, { "isoform_ac": "Q2NKS2-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2/entry#Q2NKS2-1", "sequence": { "sequence": "MFGYAVRRALRKSKTLRYGVPMLLLIVGGSFGLREFSQIRYDAVKIKIDPELEKKLKMNKVSLESEYEKIKDSTFDDWKNIRGPRPWEDPDLLQGRNPEILKTNKTT", "length": 107, "header": "sp|Q2NKS2-1|COX16_BOVIN Isoform 1 of Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Bos taurus OX=9913 GN=COX16 PE=3 SV=1 CANONICAL=Q2NKS2-1" }, "locus": { "chromosome": "10", "start_pos": 82060625, "end_pos": 82046966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020832.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020832.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020832.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020832.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615979", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615979", "resource": "KEGG Pathway" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S4A8-1", "protein_name": "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "gene_name": "COX16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFPQAVMRAFRKNKTLRYGVPMLLLVVGGSFGLREFSQIRYDAVKIKIDPELEKKLKMNKVSLESEYEKIKDSTFDDWKNIRGPRPWEDPDLLQGRNPEILKTKTT", "length": 106 }, "evidence": [ { "id": "Q2NKS2", "url": "https://omabrowser.org/oma/group/Q2NKS2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9CR63-1", "protein_name": "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "gene_name": "Cox16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIAPAVLRALRKNKTLRYGVPMLLLVVGGSFGLREFSQIRYDAVTIKIDPELEKKLKVNKITLESEYEKIKDSTFENWKNIRGPRPWEDPQLLQGRNPETLKPKTT", "length": 106 }, "evidence": [ { "id": "Q2NKS2", "url": "https://omabrowser.org/oma/group/Q2NKS2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0S2-1", "protein_name": "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "gene_name": "COX16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENKISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT", "length": 106 }, "evidence": [ { "id": "Q2NKS2", "url": "https://omabrowser.org/oma/group/Q2NKS2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VF98-1", "protein_name": "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial", "gene_name": "l(3)neo43", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLVDKLNYYSTRKSFKYGIPFLIMMVAGSFGLQQFSNLRYQYAKKQPVTPEEMKKYGVSMKNRKDVTLESEYDKVKSVDIENWENKRGPRPWEEQEDQPTTAKH", "length": 105 }, "evidence": [ { "id": "Q2NKS2", "url": "https://omabrowser.org/oma/group/Q2NKS2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS2", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS2", "url": "https://www.uniprot.org/uniprotkb/Q2NKS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKS2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 107, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKS2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKS2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBU5-1", "uniprot_ac": "Q2TBU5", "uniprot_id": "NT5D1_BOVIN", "mass": { "chemical_mass": 51365.0, "monoisotopic_mass": 51365.0 }, "refseq": { "ac": "NP_001098955", "name": "5'-nucleotidase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098955" }, "gene_names": [ { "name": "NT5DC1", "type": "recommended", "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ] }, { "name": "NT5DC1", "type": "synonym", "evidence": [ { "id": "NP_001098955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098955" } ] } ], "protein_names": [ { "name": "5'-nucleotidase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.-", "type": "synonym", "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5/entry#names_and_taxonomy" } ] }, { "name": "5'-nucleotidase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001098955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098955" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBU5", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NT5DC1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5", "locus": { "chromosome": "9", "start_pos": 34459444, "end_pos": 34566772, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003076", "url": "https://www.ensembl.org/id/ENSBTAG00000003076" } ] } } ], "crossref": [ { "id": "Q2TBU5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003076", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003076", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100125914", "url": "https://www.ncbi.nlm.nih.gov/gene/100125914", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125914", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125914", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICSNPYG", "url": "https://omabrowser.org/oma/group/ICSNPYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUR4", "url": "https://www.orthodb.org/?gene=A0A3Q1LUR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBU5", "url": "https://www.orthodb.org/?gene=Q2TBU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12103:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12103:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05761", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05761", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098955", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBU5", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBU5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCCYNLPESARLIYNSFAQFLVKEKGYDKGLLTVTPEDWDFCCKGLALDLEDGNFIKLADNGTVLRASHGTKMLSAEALAEEFGRKEWKHFMPDTGMAFRSGKYYFYDNYFDLPGALLCARVVDSLTKQNNGQKPFDFWKDIVAGIQHNYKMSAFKENCGIYFPEIKRDPGKYLHTCPESVKKWLRQLKNAGKILMLITSSHSDYCRLLCQYILGNDFEDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEREALPFLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPACHYSNWETVLILEELRGDKDGKPEESEPEEKKGKYEGSKAKPLNTSSKKWGSFFIDSVSGLENREDSLVYTWSCKRISAYSTIAIPSIEAIAELPLDYKFTRFSSNNSKTAGYYPNPPLVLSNAGKLTAK", "length": 452, "header": "sp|Q2TBU5-1|NT5D1_BOVIN Isoform 1 of 5'-nucleotidase domain-containing protein 1 OS=Bos taurus OX=9913 GN=NT5DC1 PE=2 SV=1 CANONICAL=Q2TBU5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUR4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5/entry#A0A3Q1LUR4-1", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCCYNLPESARLIYNSFAQFLVKEKGYDKGLLTVTPEDWDFCCKGLALDLEDGNFIKLADNGTFKIVFFLGKYYFYDNYFDLPGALLCARVVDSLTKQNNGQKPFDFWKDIVAGIQHNYKMSAFKENCGIYFPEIKRDPGKYLHTCPESVKKWLRQLKNAGKILMLITSSHSDYCRLLCQYILGNDFEDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEREALPFLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPACHYSNWETVLILEELRGDKDGKPEESEPEEKKGKYEGSKAKPLNTSSKKWGSFFIDSVSGLENREDSLVYTWSCKRISAYSTIAIPSIEAIAELPLDYKFTRFSSNNSKTAGYYPNPPLVLSNAGKLTAK", "length": 421, "header": "tr|A0A3Q1LUR4-1|A0A3Q1LUR4_BOVIN Computationally mapped isoform of 5'-nucleotidase domain-containing protein 1 OS=Bos taurus OX=9913 GN=NT5DC1 PE=3 SV=1 CANONICAL=Q2TBU5-1" }, "locus": { "chromosome": "9", "start_pos": 34566768, "end_pos": 34459568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081364.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081364.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058975.1" } ] } }, { "isoform_ac": "A0AAA9TFK4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5/entry#A0AAA9TFK4-1", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCCYNLPESARLIYNSFAQFLVKEKGYDKGLLTVTPEDWDFCCKGLALDLEDGNFIKLADNGTVLRASHGTKMLSAEALAEEFGRKEWKHFMPDTGMAFRSGKYYFYDNYFDLPGALLCARVVDSLTKQNNGQKPFDFWKDIVAGIQHNYKMSAFKENCGIYFPEIKRDPGKYLHTCPESVKKWLRQLKNAGKILMLITSSHSDYCRLLCQYILGNDFEDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEREALPFLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPACHYSNWETVLILEELRGDKDGKPEESEPEEKKGKYEGSKAKPLNTSSKKWGSFFIDSVSGLENREDSLVYTWSCKRISAYSTIAIPSIEAIAVLFNEPF", "length": 421, "header": "tr|A0AAA9TFK4-1|A0AAA9TFK4_BOVIN Computationally mapped isoform of 5'-nucleotidase domain-containing protein 1 OS=Bos taurus OX=9913 GN=NT5DC1 PE=3 SV=1 CANONICAL=Q2TBU5-1" }, "locus": { "chromosome": "9", "start_pos": 34566768, "end_pos": 34460937, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096930.1" } ] } }, { "isoform_ac": "Q2TBU5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5/entry#Q2TBU5-1", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCCYNLPESARLIYNSFAQFLVKEKGYDKGLLTVTPEDWDFCCKGLALDLEDGNFIKLADNGTVLRASHGTKMLSAEALAEEFGRKEWKHFMPDTGMAFRSGKYYFYDNYFDLPGALLCARVVDSLTKQNNGQKPFDFWKDIVAGIQHNYKMSAFKENCGIYFPEIKRDPGKYLHTCPESVKKWLRQLKNAGKILMLITSSHSDYCRLLCQYILGNDFEDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEREALPFLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPACHYSNWETVLILEELRGDKDGKPEESEPEEKKGKYEGSKAKPLNTSSKKWGSFFIDSVSGLENREDSLVYTWSCKRISAYSTIAIPSIEAIAELPLDYKFTRFSSNNSKTAGYYPNPPLVLSNAGKLTAK", "length": 452, "header": "sp|Q2TBU5-1|NT5D1_BOVIN Isoform 1 of 5'-nucleotidase domain-containing protein 1 OS=Bos taurus OX=9913 GN=NT5DC1 PE=2 SV=1 CANONICAL=Q2TBU5-1" }, "locus": { "chromosome": "9", "start_pos": 34566768, "end_pos": 34459568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004003.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004003.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004003.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004003.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100125914", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125914", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WC66-1", "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "Nt5dc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCRYNLSESAALIYNSFAQFLVKEKGYDEELLTLTLEDWDFCCKGLALDLEDGTFIKLAADGTVLRASHGTKMMTPEALTEAYGKKEWRHCLSDKRSVSGSDIPCCSGKCYFYDNYFDLPGALLCAKVVDSLTKQNRGQKTFDFWKDVVAGIQHNFKMSAFKENCGFFFPEIKRNLGKYVYRCPESVKKWLQQIKDAGKITMLITSSHSDYCKLLGSYILGKDFADLFDIVITNALKPGFFSHFPSQRSFYTLENDEEKDELPSLDKPGWYSQGNAVHLYELLKKMTSKLEPKVVYFGDSMHSDIFPAHHYTNWETVLILEELQGQEMEKPEEAEPLEKRGKYEGPKVKPLNCLSNKWGSYFIDSVSRRGNAEDSLVYTWSSKRISTYSTIAIPNIESIAELPLDYKFTRFSANNSKTAGYYPLVHYTLASQNTDSKIIST", "length": 461 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C3Z6-1", "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "NT5DC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQQYFSLADCEVMGFDLDHTLCRYHLPQSAALIYDSFAQYLVTEKGYDKDLLTLNPESLDFCCKGLALDLEDGNFLKLAEDGTVLRASHGTRSMTSEEILEIYGRREWKHFSTVSGMLSRSAKYYLYDNYFDLPGALLCARVVDSLDQHDGQKKYDFWKDMVAAIQHNYKISAFKEDCGTYFPEVKNHPEKYLQRCPSSVKKWLKQLKSAGKILLLITSSHSDYCRLLCEYILGNDFEEYFDVVITNALKPGFFSHTPNQRPFRTLENDEEQEALLSLDKPGWYSQGNAIHLYELLKKMTGKLDPKVVYFGDSMHSDIFPARHYSNWETVFILEELLGDKVMVPTETESEPLEKKGKYEGYQPKIPYSVSEQWGSFFVDRLPGLENAEETLVRTWSCKCISTYSTIAIPSLEAIADLPLDYRFTRFSSNSSATAGYYPSPPRALLPSEESVTMK", "length": 454 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "K7GPB8-1", "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "NT5DC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCRYNLPESARLIYNSFAQFLVREKGYDKELLTVTPEDWDFCCKGLALDLEDGNFIKLADNGTVLRASHGTKMLTPEALEEEYGQKEWKHFLSDSGTACRSGKYYFYDNYFDLPGALLCARVVDSLTKQNSGQKPFDFWKDIVAGIQHNYKMSAFKENCGIYFPEIKRDPGRYLHTCPESVKKWLRQLKNAGKILMLITSSHSDYCRLLCRYILGNDFEDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEALPSLDKPGWYSQGNAVHLYELLKKMTGQPEPKVVYFGDSMHSDIFPASHYSNWETVLILEELRGDRDGKPEDAEPLEKKGKYEGPKAKPLNALSKKWGSFFIDSVSGLENTKDSLVYTWSCKRISAYSTIAIPSIEAIAELPLDYKFTRFSSNNSKTAGYYPNPPLVLLNDGMLTAK", "length": 452 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54JY6-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKIEEIINTEIKLHQQFKNVNVIGFDMDMAIVRYNNNETATLIYECVLEHLVTVFPFLKESKLDFSFSKRGLVIDLELGLILKLDNKKRVIKAFRGKSIVSKEEIDSIYHDEKVIGSESPLKDYDGSNSARFFTMISFFETPITSVIRDFMEYQNSESIRLGKPIDYSTFKQLAKEISISFAKHFNDFTTGHYYTSFKKDPSKYIYKVSNRLKNWLMEIRSKNNTKVILITNSKSEYCHSVMEYSFGENFRDYFDCIIVDAKKPEFFKSDINSKPFTKLMTFYPKEKSDYIECSNIELGVSHDTIFKGGNIHLVLNKLKDHFKKDQISFCYVGDNLIGDVVAPKQVKLMTVAIIEEIQDPDEIIILKREKNTKSQEVQVNSEGLVERSTGKTNYVWGSFFHIHDDHENLSIDTFWSSILRDNADIVVYGVDTLVEYYYQDKFDNKDTLSPCAVVYGGY", "length": 459 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5TFE4-1", "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "NT5DC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQHFSLAACDVVGFDLDHTLCRYNLPESAPLIYNSFAQFLVKEKGYDKELLNVTPEDWDFCCKGLALDLEDGNFLKLANNGTVLRASHGTKMMTPEVLAEAYGKKEWKHFLSDTGMACRSGKYYFYDNYFDLPGALLCARVVDYLTKLNNGQKTFDFWKDIVAAIQHNYKMSAFKENCGIYFPEIKRDPGRYLHSCPESVKKWLRQLKNAGKILLLITSSHSDYCRLLCEYILGNDFTDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEALPSLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPARHYSNWETVLILEELRGDEGTRSQRPEESEPLEKKGKYEGPKAKPLNTSSKKWGSFFIDSVLGLENTEDSLVYTWSCKRISTYSTIAIPSIEAIAELPLDYKFTRFSSSNSKTAGYYPNPPLVLSSDETLISK", "length": 455 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C5P5-1", "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "Nt5dc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQHFSLGACDVVGFDLDHTLCRYNLPESARLIYNSFAQFLVKEKGYDEGLLTLTPEDWDFCCKGLALDLEDGTFIKLAADGTVLRASHGTKMMTPEALTEAFGKKEWRHCVSDKRCTSDKPGVSDIPCCSGKCYFYDNYFDLPGALLCARVVDSLTKQNRGQKTFDFWKDVVAGIQHNFKMSAFKENCGFFFPEIKRNLGKYVHRCPESVRKWLRQLKDAGKITMLITSSHSDYCKLLGSYILGEDFADLFDIVITNALKPGFFSHFPSQRPFYTLENDEEKDELPSLDKPGWYSQGNAAHLYELLKKMTSKPEPKVVYFGDSMHSDIFPAHHYTNWETVLILEELQGPEMEKPEEAEPLEKRGKYEAPMVKPLNTLSNKWGSYFIDSVSGRGRAEDSVVYTWSSKRISTYSTIAIPNIESIAELPLDYKFTRFSTNNSKMAGYYPLVHHTLGSQDTDSKIISTEK", "length": 467 }, "evidence": [ { "id": "Q2TBU5", "url": "https://omabrowser.org/oma/group/Q2TBU5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU5", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "pmid": "" }, { "name": "5'-nucleotidase activity", "id": "GO:0008253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008253", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU5", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU5", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 452, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBU5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5#function" }, { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "binding_site_uniprot": 16, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 16, "end_pos": 16, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5#function" }, { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "binding_site_uniprot": 18, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 18, "end_pos": 18, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5#function" }, { "id": "Q2TBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU5" } ], "binding_site_uniprot": 313, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 313, "end_pos": 313, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 366, "end_pos": 368 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBD2-1", "uniprot_ac": "Q3ZBD2", "uniprot_id": "ARP10_BOVIN", "mass": { "chemical_mass": 46297.0, "monoisotopic_mass": 46297.0 }, "refseq": { "ac": "NP_001029572", "name": "actin-related protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" }, "gene_names": [ { "name": "ACTR10", "type": "recommended", "evidence": [ { "id": "Q3ZBD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ] }, { "name": "ACTR10", "type": "synonym", "evidence": [ { "id": "NP_001029572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" } ] }, { "name": "ARP10", "type": "synonym", "evidence": [ { "id": "Q3ZBD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ] } ], "protein_names": [ { "name": "Actin-related protein 10", "type": "recommended", "evidence": [ { "id": "Q3ZBD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2/entry#names_and_taxonomy" } ] }, { "name": "actin related protein 10 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" } ] }, { "name": "actin-related protein 10", "type": "synonym", "evidence": [ { "id": "NP_001029572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" } ] } ], "function": [ { "annotation": "Bovine ACTR10 encodes a protein that crosslinks to dynactin p62 (encoded by DCTN4) and dynactin p25 (encoded by DCTN5), BMH treated bovine brain dynactin.", "evidence": [ { "database": "RefSeq", "id": "NP_001029572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" }, { "database": "PubMed", "id": "22918948", "url": "https://glygen.org/publication/PubMed/22918948" } ] }, { "annotation": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2#function" }, { "database": "UniProtKB", "id": "I3LHK5", "url": "https://www.uniprot.org/uniprotkb/I3LHK5#function" }, { "database": "UniProtKB", "id": "A0AAA9S5I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I1#function" }, { "database": "UniProtKB", "id": "ARBA00034687", "url": "https://www.uniprot.org/uniprotkb/ARBA00034687#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTR10", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2", "locus": { "chromosome": "10", "start_pos": 70541958, "end_pos": 70515434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014392", "url": "https://www.ensembl.org/id/ENSBTAG00000014392" } ] } } ], "crossref": [ { "id": "Q3ZBD2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014392", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014392", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10207", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10207", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511083", "url": "https://www.ncbi.nlm.nih.gov/gene/511083", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511083", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511083", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WERDNDN", "url": "https://omabrowser.org/oma/group/WERDNDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWM1", "url": "https://www.orthodb.org/?gene=A0A3Q1LWM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBD2", "url": "https://www.orthodb.org/?gene=Q3ZBD2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3371497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBD2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGILEDIKVRTCFVSDLKRGLNIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLATKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKDYYNQTGRIPDWCSLNNPPLEMMFDVGKNQPPLMKRAFSTEK", "length": 417, "header": "sp|Q3ZBD2-1|ARP10_BOVIN Isoform 1 of Actin-related protein 10 OS=Bos taurus OX=9913 GN=ACTR10 PE=2 SV=1 CANONICAL=Q3ZBD2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2/entry#A0A3Q1LWM1-1", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKVFFLNKLSITQENFFDYLGLILHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGILEDIKVRTCFVSDLKRGLNIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLATKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKDYYNQTGRIPDWCSLNNPPLEMMFDVGKNQPPLMKRAFSTEK", "length": 411, "header": "tr|A0A3Q1LWM1-1|A0A3Q1LWM1_BOVIN Computationally mapped isoform of Actin related protein 10 OS=Bos taurus OX=9913 GN=ACTR10 PE=3 SV=1 CANONICAL=Q3ZBD2-1" }, "locus": { "chromosome": "10", "start_pos": 70541723, "end_pos": 70515501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077747.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077747.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059840.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059840.1" } ] } }, { "isoform_ac": "A0AAA9S5I1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2/entry#A0AAA9S5I1-1", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGILEDIKVRTCFVSDLKRGLNIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRFLCPWDSPGKNTGVGCHSLLQELFRTQGLNWGLLHCRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLATKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKDYYNQTGRIPDWCSLNNPPLEMMFDVGKNQPPLMKRAFSTEK", "length": 454, "header": "tr|A0AAA9S5I1-1|A0AAA9S5I1_BOVIN Computationally mapped isoform of Actin-related protein 10 OS=Bos taurus OX=9913 GN=ACTR10 PE=3 SV=1 CANONICAL=Q3ZBD2-1" }, "locus": { "chromosome": "10", "start_pos": 70541723, "end_pos": 70515501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130571.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130571.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078496.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078496.1" } ] } }, { "isoform_ac": "Q3ZBD2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2/entry#Q3ZBD2-1", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGILEDIKVRTCFVSDLKRGLNIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLATKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKDYYNQTGRIPDWCSLNNPPLEMMFDVGKNQPPLMKRAFSTEK", "length": 417, "header": "sp|Q3ZBD2-1|ARP10_BOVIN Isoform 1 of Actin-related protein 10 OS=Bos taurus OX=9913 GN=ACTR10 PE=2 SV=1 CANONICAL=Q3ZBD2-1" }, "locus": { "chromosome": "10", "start_pos": 70541723, "end_pos": 70515501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019138.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019138.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019138.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019138.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Dynactin's pointed-end complex is a cargo-targeting module.", "journal": "Molecular biology of the cell", "date": "2012-10", "authors": "Yeh Ting-Yu, Quintyne Nicholas J, Scipioni Brett R, Eckley D Mark, Schroer Trina A", "evidence": [ { "database": "RefSeq", "id": "NP_001029572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029572" } ], "reference": [ { "type": "PubMed", "id": "22918948", "url": "https://glygen.org/publication/PubMed/22918948" } ] } ], "pathway": [ { "id": "bta:511083", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511083", "resource": "KEGG Pathway" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GBD2-1", "protein_name": "Actin-related protein 10", "gene_name": "Actr10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMSKPIKVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKGQSLPSVMGSVPESVLEDIKVRTCFVSDLQRGLQIQAAKFNIDGNNERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLLQCPVDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLGTKNFRIHTPPAKANCVAWLGGAVFGALQDILGSRSISKEYYNQTGRTPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK", "length": 417 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NG10-1", "protein_name": "Actin-related protein 10", "gene_name": "ACTR10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVLDLGEAFTKCGFAGETGPRCIIPSEIKKPDVSKPVKVVQYNINTEELYSYLKEFIHMLYFRHLLVNPRDRRVVIIESVLCPSHFRDTLARVLFKHFEVPSVLFAPSHLMSLLTLGINSAMVLDCGYKESLVLPIYEGTPILSCWGSLPLGGKAIHKELEYRLLEQCTVDTGLAKGQSLPSVMGSVPEDVVEDIKVRTCFVSDLQRGLKIQAAKFNIDGSAERPLPPPDVDYPLDGEKILHVVGSIRDSVAEILFEQDNEETSVATLILDSLIQCPIDTRKQLAENLVVMGGTAMLPGFLHRLMAEIRYLVEKPKYKEVLATKTFKVHTPPAKPNYVAWLGGAIFGALQDILGSRSVSREYYSQTGRIPDWCCLSNPPLEMMFDVGKAPPPLMKRAFSTEK", "length": 417 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LHK5-1", "protein_name": "Actin-related protein 10", "gene_name": "ACTR10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGVLEDIKVRTCFVSDLTRGLKIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMVFDVGKSQPPLMKRAFSTEK", "length": 417 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54JY2-1", "protein_name": "Actin-related protein 10", "gene_name": "arpH", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDSKSSIVLEIGGRYTKCGYSPESSPRFIIPTNLLPLNISSYLSGGASFDNFKKEITSDNETITTTNQIPTKLPTQSQLKESLFIFFKTIFLNYLLCKSDERKIIIVENIFLPRLFRESMVSVLFEQYRVPLIVFINPTASLIPTLRTTALLIDSGFSETRVLPIYEGVGILKAYKSISLGSESLINQLKQYLQSNITNGIIIDNQNNQSITDSMICNQLLNDKILNSIQLLEDIITRCCFCSFKNKNNNNIEINNINYRISKEYSILIDGNNIRKGLVDVLYKDVNNNDNNNNNKEDDDENLEEGNIATTILNTLLKCEHDQRKPLSHNILLLGGTTMLAGFKKRLVLELHRQLKMNENSIYRNELFGLIGHFQFINHPFENNYLSWLGGSILANALEHVHSKITLESYLNAPSQFKRSQLIPEWEKLTNINNYTQIAQATMGTTINPLQFNSTSSLFSPFTSSSDLSSHLNKD", "length": 475 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9NZ32-1", "protein_name": "Actin-related protein 10", "gene_name": "ACTR10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPLDGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKALGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK", "length": 417 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZB7-1", "protein_name": "Actin-related protein 10", "gene_name": "Actr10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMSKPIKVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPILNCWGALPLGGKALHKELETQLLEQCTVDTGAAKGQSLPSVMGSVPEGVLEDIKVRTCFVSDLKRGLQIQAAKFNIDGNNERPTPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLLQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLGTKNFRIHTPPAKANCVAWLGGAVFGALQDILGSRSISKEYYNQTGRIPDWCSLNNPPLEMMFDVGKAQPPLMKRAFSTEK", "length": 417 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VWE8-1", "protein_name": "Actin-related protein 10, isoform B", "gene_name": "Arp10", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPIYESVMQEKPPIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTGIRKRLFDYDTPEELYDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIALSTLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLVESGVKESLLTESVLEDIKVRTCFVTTMERAKARANGDENQPTPAPDVDYIVSDNDAVIQVPGLLRESAYEIMFEASNERDSLPHLILRSILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGATDLIQTRSLVKETYLKSEHVPDWSNLCDNRPTGS", "length": 378 }, "evidence": [ { "id": "Q3ZBD2", "url": "https://omabrowser.org/oma/group/Q3ZBD2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" }, { "name": "dynactin complex", "id": "GO:0005869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005869", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retrograde axonal transport of mitochondrion", "id": "GO:0098958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098958", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBD2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 417, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBD2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBD2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 379, "end_pos": 381 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBY0-1", "uniprot_ac": "Q3ZBY0", "uniprot_id": "MAL_BOVIN", "mass": { "chemical_mass": 16784.0, "monoisotopic_mass": 16784.0 }, "refseq": { "ac": "NP_001068896", "name": "myelin and lymphocyte protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" }, "gene_names": [ { "name": "MAL", "type": "recommended", "evidence": [ { "id": "Q3ZBY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ] }, { "name": "MAL", "type": "synonym", "evidence": [ { "id": "NP_001068896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" } ] } ], "protein_names": [ { "name": "Myelin and lymphocyte protein", "type": "recommended", "evidence": [ { "id": "Q3ZBY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#names_and_taxonomy" } ] }, { "name": "T-lymphocyte maturation-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001068896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" } ] }, { "name": "myelin and lymphocyte protein", "type": "synonym", "evidence": [ { "id": "NP_001068896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" } ] } ], "function": [ { "annotation": "May be involved in vesicular trafficking from the Golgi apparatus to the cell membrane. Plays a role in the maintenance of the myelin sheath, and in axon-glia and glia-glia interactions.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0#function" }, { "database": "UniProtKB", "id": "O09198", "url": "https://www.uniprot.org/uniprotkb/O09198#function" } ] }, { "annotation": "SYP is an hexameric MAL-domain channel protein.", "evidence": [ { "database": "RefSeq", "id": "NP_001068896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" }, { "database": "PubMed", "id": "17562317", "url": "https://glygen.org/publication/PubMed/17562317" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAL", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0", "locus": { "chromosome": "11", "start_pos": 1873328, "end_pos": 1848632, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034586", "url": "https://www.ensembl.org/id/ENSBTAG00000034586" } ] } } ], "crossref": [ { "id": "Q3ZBY0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034586", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034586", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510077", "url": "https://www.ncbi.nlm.nih.gov/gene/510077", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510077", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510077", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIINAHG", "url": "https://omabrowser.org/oma/group/YIINAHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBY0", "url": "https://www.orthodb.org/?gene=Q3ZBY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRI6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRI6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBY0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSAASGVSSLPSGFAVFTTFPDLLFIFEFVFGGLVWILVSSSHVPIPLIQGWVMFASVFCFVATTVLAFLYVIGAHGNRTSWITLDAAYHCVASLFYFGASVLEALAAIQLQDGFLYKYYHENISAVVFSYVATLLYVVHAVFSLIRWKSS", "length": 153, "header": "sp|Q3ZBY0-1|MAL_BOVIN Isoform 1 of Myelin and lymphocyte protein OS=Bos taurus OX=9913 GN=MAL PE=2 SV=1 CANONICAL=Q3ZBY0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZE2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#A0A3Q1LZE2-1", "sequence": { "sequence": "MAPSAASGVSSLPSGFAVFTTFPDLLFIFEFVFGGLVWILVSSSHVPIPLIQGWVMFASVFCFVATTVLAFLYVIGAHGNRTSWITLVFSYVATLLYVVHAVFSLIRWKSS", "length": 111, "header": "tr|A0A3Q1LZE2-1|A0A3Q1LZE2_BOVIN Computationally mapped isoform of Myelin and lymphocyte protein OS=Bos taurus OX=9913 GN=MAL PE=3 SV=2 CANONICAL=Q3ZBY0-1" }, "locus": { "chromosome": "11", "start_pos": 1872852, "end_pos": 1848722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077739.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077739.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061072.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061072.2" } ] } }, { "isoform_ac": "A0AAA9SJL4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#A0AAA9SJL4-1", "sequence": { "sequence": "MAPSAASGVSSLPSGFAVFTTFPDLLFIFEFDAAYHCVASLFYFGASVLEALAAIQLQDGFLYKYYHENISAVVFSYVATLLYVVHAVFSLIRWKSS", "length": 97, "header": "tr|A0AAA9SJL4-1|A0AAA9SJL4_BOVIN Computationally mapped isoform of Myelin and lymphocyte protein OS=Bos taurus OX=9913 GN=MAL PE=3 SV=1 CANONICAL=Q3ZBY0-1" }, "locus": { "chromosome": "11", "start_pos": 1872852, "end_pos": 1848722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125699.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125699.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082796.1" } ] } }, { "isoform_ac": "A0AAA9TBB4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#A0AAA9TBB4-1", "sequence": { "sequence": "MAPSAASGVSSLPSGFAVFTTFPDLLFIFEFVFSYVATLLYVVHAVFSLIRWKSS", "length": 55, "header": "tr|A0AAA9TBB4-1|A0AAA9TBB4_BOVIN Computationally mapped isoform of Mal, T cell differentiation protein OS=Bos taurus OX=9913 GN=MAL PE=4 SV=1 CANONICAL=Q3ZBY0-1" }, "locus": { "chromosome": "11", "start_pos": 1872852, "end_pos": 1848722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096007.1" } ] } }, { "isoform_ac": "A0ABI0NRI6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#A0ABI0NRI6-1", "sequence": { "sequence": "MWLIEQHSLGAGSPRLALPGGLLPPGAVFGGLVWILVSSSHVPIPLIQGWVMFASVFCFVATTVLAFLYVIGAHGNRTSWITLDAAYHCVASLFYFGASVLEALAAIQLQDGFLYKYYHENISAVVFSYVATLLYVVHAVFSLIRWKSS", "length": 149, "header": "tr|A0ABI0NRI6-1|A0ABI0NRI6_BOVIN Computationally mapped isoform of Myelin and lymphocyte protein OS=Bos taurus OX=9913 GN=MAL PE=3 SV=1 CANONICAL=Q3ZBY0-1" }, "locus": { "chromosome": "11", "start_pos": 1872852, "end_pos": 1832692, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139274.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139274.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105304.1" } ] } }, { "isoform_ac": "Q3ZBY0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0/entry#Q3ZBY0-1", "sequence": { "sequence": "MAPSAASGVSSLPSGFAVFTTFPDLLFIFEFVFGGLVWILVSSSHVPIPLIQGWVMFASVFCFVATTVLAFLYVIGAHGNRTSWITLDAAYHCVASLFYFGASVLEALAAIQLQDGFLYKYYHENISAVVFSYVATLLYVVHAVFSLIRWKSS", "length": 153, "header": "sp|Q3ZBY0-1|MAL_BOVIN Isoform 1 of Myelin and lymphocyte protein OS=Bos taurus OX=9913 GN=MAL PE=2 SV=1 CANONICAL=Q3ZBY0-1" }, "locus": { "chromosome": "11", "start_pos": 1872852, "end_pos": 1848722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033229.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033229.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033149.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033149.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure of synaptophysin: a hexameric MARVEL-domain channel protein.", "journal": "Structure (London, England : 1993)", "date": "2007-06", "authors": "Arthur Christopher P, Stowell Michael H B", "evidence": [ { "database": "RefSeq", "id": "NP_001068896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068896" } ], "reference": [ { "type": "PubMed", "id": "17562317", "url": "https://glygen.org/publication/PubMed/17562317" } ] } ], "pathway": [ { "id": "bta:510077", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510077", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H024-1", "protein_name": "Myelin and lymphocyte protein", "gene_name": "Mal", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPAAASGGSTLPSGFSVFVTFPDLLFIFEFIFGGLVWILIASSLVPIALIQGWVMFVSVFCFVATTSLMVMYIIGTHGGETSWITLDAAYHCVAALFYLSASVLEALATIMMYEGYTYKQYHENISAVVFAYVATLLYVVHAVFSLIRWKSS", "length": 153 }, "evidence": [ { "id": "Q3ZBY0", "url": "https://omabrowser.org/oma/group/Q3ZBY0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O09198-1", "protein_name": "Myelin and lymphocyte protein", "gene_name": "Mal", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPAAASGGSTLPSGFSVFTTFPDLLFVCEFVFGGLVWILIASSLVPLPLAQGWVMFVSVFCFVATTSLMILYIIGTHGGETSWITLDAAYHCVAALFYLSASVLEALATISMFDGFTYKHYHENIAAVVFAYVVTLIYVVHAVFSLIRWKSS", "length": 153 }, "evidence": [ { "id": "Q3ZBY0", "url": "https://omabrowser.org/oma/group/Q3ZBY0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P21145-1", "protein_name": "Myelin and lymphocyte protein", "gene_name": "MAL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS", "length": 153 }, "evidence": [ { "id": "Q3ZBY0", "url": "https://omabrowser.org/oma/group/Q3ZBY0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64349-1", "protein_name": "Myelin and lymphocyte protein", "gene_name": "Mal", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPAAASGGSTLPSGFSVFVTFPDLLFIFEFIFGGLVWILIASSLVPMPLVQGWVMFVSVFCFLATTSLMVMYIIGTHGGETSWITLDAAYHCVAALFYLSASVLEALATITMFDGFTYRHYHENIAAVVFAYVATLLYVIHAVFSLIRWKSS", "length": 153 }, "evidence": [ { "id": "Q3ZBY0", "url": "https://omabrowser.org/oma/group/Q3ZBY0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of myelin sheath", "id": "GO:0019911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019911", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "pmid": "" }, { "name": "protein insertion into plasma membrane", "id": "GO:0098737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBY0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY0" }, { "id": "PRU00581", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00581" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MARVEL", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 151, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBS2-1", "uniprot_ac": "Q3ZBS2", "uniprot_id": "TAFA5_BOVIN", "mass": { "chemical_mass": 14329.0, "monoisotopic_mass": 14329.0 }, "refseq": { "ac": "NP_001070468", "name": "chemokine-like protein TAFA-5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" }, "gene_names": [ { "name": "TAFA5", "type": "recommended", "evidence": [ { "id": "Q3ZBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ] }, { "name": "FAM19A5", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" }, { "id": "Q3ZBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ] }, { "name": "TAFA5", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] } ], "protein_names": [ { "name": "Chemokine-like protein TAFA-5", "type": "recommended", "evidence": [ { "id": "Q3ZBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2/entry#names_and_taxonomy" } ] }, { "name": "chemokine-like protein TAFA-5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] }, { "name": "chemokine-like protein TAFA-5", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] }, { "name": "family with sequence similarity 19 (chemokine (C-C motif)-like), member A5", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] }, { "name": "family with sequence similarity 19 member A5, C-C motif chemokine like", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] }, { "name": "protein FAM19A5", "type": "synonym", "evidence": [ { "id": "NP_001070468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468" } ] } ], "function": [ { "annotation": "Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2#function" }, { "database": "UniProtKB", "id": "M0R7X9", "url": "https://www.uniprot.org/uniprotkb/M0R7X9#function" }, { "database": "UniProtKB", "id": "Q91WE9", "url": "https://www.uniprot.org/uniprotkb/Q91WE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAFA5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2", "locus": { "chromosome": "5", "start_pos": 118480465, "end_pos": 118304835, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022986", "url": "https://www.ensembl.org/id/ENSBTAG00000022986" } ] } } ], "crossref": [ { "id": "Q3ZBS2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022986", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022986", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767927", "url": "https://www.ncbi.nlm.nih.gov/gene/767927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TTSTHEM", "url": "https://omabrowser.org/oma/group/TTSTHEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2J6", "url": "https://www.orthodb.org/?gene=A0A3Q1M2J6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBS2", "url": "https://www.orthodb.org/?gene=Q3ZBS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31878", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31878", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31878:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31878:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070468", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2J6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2J6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC17", "url": "https://www.uniprot.org/uniprotkb/F1MC17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC17-1", "url": "https://www.uniprot.org/uniprotkb/F1MC17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIRTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS", "length": 132, "header": "sp|Q3ZBS2-1|TAFA5_BOVIN Isoform 1 of Chemokine-like protein TAFA-5 OS=Bos taurus OX=9913 GN=TAFA5 PE=2 SV=2 CANONICAL=Q3ZBS2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2J6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2/entry#A0A3Q1M2J6-1", "sequence": { "sequence": "MQLLKALWALAGAALCCFLVLVIHAQFLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIRTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS", "length": 125, "header": "tr|A0A3Q1M2J6-1|A0A3Q1M2J6_BOVIN Computationally mapped isoform of TAFA chemokine like family member 5 OS=Bos taurus OX=9913 GN=TAFA5 PE=3 SV=1 CANONICAL=Q3ZBS2-1" }, "locus": { "chromosome": "5", "start_pos": 118479553, "end_pos": 118376321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086589.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086589.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067646.1" } ] } }, { "isoform_ac": "F1MC17-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2/entry#F1MC17-1", "sequence": { "sequence": "MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIRTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVCTQPPGCPGVQGPEQAGLGVDPTPATARSRAPAS", "length": 165, "header": "tr|F1MC17-1|F1MC17_BOVIN Computationally mapped isoform of TAFA chemokine like family member 5 OS=Bos taurus OX=9913 GN=TAFA5 PE=3 SV=3 CANONICAL=Q3ZBS2-1" }, "locus": { "chromosome": "5", "start_pos": 118479553, "end_pos": 118304894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031229.5", "url": "https://www.ensembl.org/id/ENSBTAT00000031229.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031185.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031185.5" } ] } }, { "isoform_ac": "Q3ZBS2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2/entry#Q3ZBS2-1", "sequence": { "sequence": "MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIRTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS", "length": 132, "header": "sp|Q3ZBS2-1|TAFA5_BOVIN Isoform 1 of Chemokine-like protein TAFA-5 OS=Bos taurus OX=9913 GN=TAFA5 PE=2 SV=2 CANONICAL=Q3ZBS2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 113, "start_aa": "Asn", "end_pos": 113, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn113", "evidence": [ { "id": "Q3ZBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767927", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767927", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QIB8-1", "protein_name": "Chemokine-like protein TAFA-5a isoform 1", "gene_name": "tafa5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAPAVRSIKRKDAINWPRMSTTFWAVLLLTALLIVYCGQLAAGTCEIVTLDKDSSQPRRTIARQTARCACKKGQIAGTTNARPACVDARIVKTKQWCDMVPCLEDEECDLLVNKSGWTCTQPSGRVKTTTGVI", "length": 133 }, "evidence": [ { "id": "Q3ZBS2", "url": "https://omabrowser.org/oma/group/Q3ZBS2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBS2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 132, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBS2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBS2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 113 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L96-1", "uniprot_ac": "Q32L96", "uniprot_id": "PHIPL_BOVIN", "mass": { "chemical_mass": 42562.0, "monoisotopic_mass": 42562.0 }, "refseq": { "ac": "NP_001073266", "name": "phytanoyl-CoA hydroxylase interacting protein-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073266" }, "gene_names": [ { "name": "PHYHIPL", "type": "recommended", "evidence": [ { "id": "Q32L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ] }, { "name": "PHYHIPL", "type": "synonym", "evidence": [ { "id": "NP_001073266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073266" } ] } ], "protein_names": [ { "name": "Phytanoyl-CoA hydroxylase interacting protein-like", "type": "recommended", "evidence": [ { "id": "Q32L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L96/entry#names_and_taxonomy" } ] }, { "name": "phytanoyl-CoA hydroxylase interacting protein-like", "type": "synonym", "evidence": [ { "id": "NP_001073266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073266" } ] } ], "function": [ { "annotation": "May play a role in the development of the central system.", "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBM1#function" }, { "database": "UniProtKB", "id": "ARBA00037571", "url": "https://www.uniprot.org/uniprotkb/ARBA00037571#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2T4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHYHIPL", "url": "https://www.uniprot.org/uniprotkb/Q32L96", "locus": { "chromosome": "28", "start_pos": 14883124, "end_pos": 14787564, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010947", "url": "https://www.ensembl.org/id/ENSBTAG00000010947" } ] } } ], "crossref": [ { "id": "Q32L96", "url": "https://alphafold.ebi.ac.uk/entry/Q32L96", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "780878", "url": "https://www.ncbi.nlm.nih.gov/gene/780878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:780878", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780878", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KINCITC", "url": "https://omabrowser.org/oma/group/KINCITC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2T4", "url": "https://www.orthodb.org/?gene=A0A3Q1M2T4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBM1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32L96", "url": "https://www.orthodb.org/?gene=Q32L96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15698", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15698", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15698:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15698:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073266", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2T4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2T4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L96-1", "url": "https://www.uniprot.org/uniprotkb/Q32L96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L96-2", "url": "https://www.uniprot.org/uniprotkb/Q32L96-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGIAEMEELPVPRNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYIREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRLPQLNSQDNKFLTCREEDGMLVYHHAQDVILEVIYTDPVGLSLGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR", "length": 376, "header": "sp|Q32L96-1|PHIPL_BOVIN Isoform 1 of Phytanoyl-CoA hydroxylase interacting protein-like OS=Bos taurus OX=9913 GN=PHYHIPL PE=2 SV=2 CANONICAL=Q32L96-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2T4-1", "url": "https://www.uniprot.org/uniprotkb/Q32L96/entry#A0A3Q1M2T4-1", "sequence": { "sequence": "MIPHKSKIQHLLFSGRSTSLSIISSQSIYAEADGKISFFIGNKSQDSGIAEMEELPVPRNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYIREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRLPQLNSQDNKFLTCREEDGMLVYHHAQDVILEVIYTDPVGLSLGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR", "length": 381, "header": "tr|A0A3Q1M2T4-1|A0A3Q1M2T4_BOVIN Computationally mapped isoform of Phytanoyl-CoA 2-hydroxylase interacting protein like OS=Bos taurus OX=9913 GN=PHYHIPL PE=3 SV=3 CANONICAL=Q32L96-1" }, "locus": { "chromosome": "28", "start_pos": 14882120, "end_pos": 14787866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077234.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077234.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062431.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062431.3" } ] } }, { "isoform_ac": "A0A3Q1MBM1-1", "url": "https://www.uniprot.org/uniprotkb/Q32L96/entry#A0A3Q1MBM1-1", "sequence": { "sequence": "ICRDSEYVARNKSQDSGIAEMEELPVPRNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYIREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRLPQLNSQDNKFLTCREEDGMLVYHHAQDVILEVIYTDPVGLSLGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR", "length": 350, "header": "tr|A0A3Q1MBM1-1|A0A3Q1MBM1_BOVIN Computationally mapped isoform of Phytanoyl-CoA 2-hydroxylase interacting protein like OS=Bos taurus OX=9913 GN=PHYHIPL PE=3 SV=2 CANONICAL=Q32L96-1" }, "locus": { "chromosome": "28", "start_pos": 14882120, "end_pos": 14788536, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080846.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080846.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067681.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067681.2" } ] } }, { "isoform_ac": "Q32L96-1", "url": "https://www.uniprot.org/uniprotkb/Q32L96/entry#Q32L96-1", "sequence": { "sequence": "MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGIAEMEELPVPRNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYIREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRLPQLNSQDNKFLTCREEDGMLVYHHAQDVILEVIYTDPVGLSLGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR", "length": 376, "header": "sp|Q32L96-1|PHIPL_BOVIN Isoform 1 of Phytanoyl-CoA hydroxylase interacting protein-like OS=Bos taurus OX=9913 GN=PHYHIPL PE=2 SV=2 CANONICAL=Q32L96-1" }, "locus": { "chromosome": "28", "start_pos": 14882120, "end_pos": 14787763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104352.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104352.1" } ] } }, { "isoform_ac": "Q32L96-2", "url": "https://www.uniprot.org/uniprotkb/Q32L96/entry#Q32L96-2", "sequence": { "sequence": "MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGIAEMEELPVPRNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYIREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRSPDPLLSIFVTQMFSTEACTCHCHQERATTSQISELL", "length": 288, "header": "sp|Q32L96-2|PHIPL_BOVIN Isoform 2 of Phytanoyl-CoA hydroxylase interacting protein-like OS=Bos taurus OX=9913 GN=PHYHIPL PE=2 SV=2 CANONICAL=Q32L96-1" }, "locus": { "chromosome": "28", "start_pos": 14882276, "end_pos": 14787763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031362.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031362.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031317.4", "url": "https://www.ensembl.org/id/ENSBTAP00000031317.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 23, "start_aa": "Asn", "end_pos": 23, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn23", "evidence": [ { "id": "Q32L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L96#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 37, "start_aa": "Asn", "end_pos": 37, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn37", "evidence": [ { "id": "Q32L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L96#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ], "site_lbl": "Ser12" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ], "site_lbl": "Ser15" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ], "site_lbl": "Ser25" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:780878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780878", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32L96", "url": "https://www.uniprot.org/uniprotkb/Q32L96" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L96-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L96-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L96" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L96" }, { "id": "PRU00316", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00316" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000255", "start_pos": 52, "end_pos": 161, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 23, 37 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 12, 15, 25 ], "sequon_annotation_sites": [ { "start_pos": 23, "end_pos": 25 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KN7-1", "uniprot_ac": "Q32KN7", "uniprot_id": "ZC21B_BOVIN", "mass": { "chemical_mass": 24263.0, "monoisotopic_mass": 24263.0 }, "refseq": { "ac": "NP_001070531", "name": "zinc finger C2HC domain-containing protein 1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" }, "gene_names": [ { "name": "ZC2HC1B", "type": "recommended", "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" } ] }, { "name": "C6orf94", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" } ] }, { "name": "C9H6orf94", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" } ] }, { "name": "FAM164B", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" } ] }, { "name": "ZC2HC1B", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" } ] } ], "protein_names": [ { "name": "Zinc finger C2HC domain-containing protein 1B", "type": "recommended", "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7/entry#names_and_taxonomy" } ] }, { "name": "protein FAM164B", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" } ] }, { "name": "zinc finger C2HC domain-containing protein 1B", "type": "synonym", "evidence": [ { "id": "NP_001070531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KN7", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZC2HC1B", "url": "https://www.uniprot.org/uniprotkb/Q32KN7", "locus": { "chromosome": "9", "start_pos": 81360622, "end_pos": 81316749, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008159", "url": "https://www.ensembl.org/id/ENSBTAG00000008159" } ] } } ], "crossref": [ { "id": "Q32KN7", "url": "https://alphafold.ebi.ac.uk/entry/Q32KN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008159", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008159", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768003", "url": "https://www.ncbi.nlm.nih.gov/gene/768003", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768003", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768003", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ARHEPIC", "url": "https://omabrowser.org/oma/group/ARHEPIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M312", "url": "https://www.orthodb.org/?gene=A0A3Q1M312", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32KN7", "url": "https://www.orthodb.org/?gene=Q32KN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13913", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13913", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070531", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M312", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M312", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M312-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M312-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN7", "url": "https://www.uniprot.org/uniprotkb/Q32KN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAQPFLADGNQELFPCEVCGRRFAADVLERHGPICRKLFNKKRKPFNSLKQRLRGTDIPTVGKAPQSKPQPVRKSNWRQHHEDFINAIQSAKQCTLAIKEGRPLPPPPPPTVNPDYIQCPYCKRRFNETAASRHINFCKDQESRRVFDPAQTAARLASRAQGRAQMSPKKELTVTSAVGALLQNRALEASAAPTRPAVDPASGAKLRQGFAKSSKKD", "length": 219, "header": "sp|Q32KN7-1|ZC21B_BOVIN Isoform 1 of Zinc finger C2HC domain-containing protein 1B OS=Bos taurus OX=9913 GN=ZC2HC1B PE=2 SV=1 CANONICAL=Q32KN7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M312-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN7/entry#A0A3Q1M312-1", "sequence": { "sequence": "MAGAQPFLADGNQELFPCEVCGRRFAADVLERHGPICRKLFNKKRKPFNSLKQRLRGTDIPTVGKAPQSKPQPVRKSNWRQHHEDFINAIQSAKQCTLAIKEGRPLPPPPPPTVNPDYIQCPYCKRRFNETAASRHINFCKDQESRRVFDPAQTAARLASRAQGRAQMSPKKELTVTSAVGALLQNRALEASAAPTRPGSAVDPASGAKLRQGFAKSSKKD", "length": 221, "header": "tr|A0A3Q1M312-1|A0A3Q1M312_BOVIN Computationally mapped isoform of Zinc finger C2HC-type containing 1B OS=Bos taurus OX=9913 GN=ZC2HC1B PE=4 SV=2 CANONICAL=Q32KN7-1" }, "locus": { "chromosome": "9", "start_pos": 81360605, "end_pos": 81316787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079028.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079028.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064453.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064453.3" } ] } }, { "isoform_ac": "Q32KN7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN7/entry#Q32KN7-1", "sequence": { "sequence": "MAGAQPFLADGNQELFPCEVCGRRFAADVLERHGPICRKLFNKKRKPFNSLKQRLRGTDIPTVGKAPQSKPQPVRKSNWRQHHEDFINAIQSAKQCTLAIKEGRPLPPPPPPTVNPDYIQCPYCKRRFNETAASRHINFCKDQESRRVFDPAQTAARLASRAQGRAQMSPKKELTVTSAVGALLQNRALEASAAPTRPAVDPASGAKLRQGFAKSSKKD", "length": 219, "header": "sp|Q32KN7-1|ZC21B_BOVIN Isoform 1 of Zinc finger C2HC domain-containing protein 1B OS=Bos taurus OX=9913 GN=ZC2HC1B PE=2 SV=1 CANONICAL=Q32KN7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768003", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768003", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5TFG8-1", "protein_name": "Zinc finger C2HC domain-containing protein 1B", "gene_name": "ZC2HC1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAEPFLADGNQELFPCEVCGRRFAADVLERHGPICKKLFNRKRKPFSSLKQRLQGTDIPTVKKTPQSKSPPVRKSNWRQQHEDFINAIRSAKQCMLAIKEGRPLPPPPPPSLNPDYIQRPYCMRRFNESAAERHTNFCKDQSSRRVFNPAQTAAKLASRAQGRAQMGPKKEPTVTSAVGALLQNRVLVATNEVPTKSGLAMDPASGAKLRQGFSKSSKKD", "length": 222 }, "evidence": [ { "id": "Q32KN7", "url": "https://omabrowser.org/oma/group/Q32KN7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32KN7", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KN7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KN7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KN7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 121, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 121, "end_pos": 121, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 124, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 124, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 136, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 136, "end_pos": 136, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 140, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 140, "end_pos": 140, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 18, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 18, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 21, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 21, "end_pos": 21, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 33, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 33, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7#function" }, { "id": "Q32KN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN7" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 37, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 37, "end_pos": 37, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DT0-1", "uniprot_ac": "Q58DT0", "uniprot_id": "ELF5_BOVIN", "mass": { "chemical_mass": 30090.0, "monoisotopic_mass": 30090.0 }, "refseq": { "ac": "NP_001019740", "name": "ETS-related transcription factor Elf-5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" }, "gene_names": [ { "name": "ELF5", "type": "recommended", "evidence": [ { "id": "Q58DT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ] }, { "name": "ELF5", "type": "synonym", "evidence": [ { "id": "NP_001019740", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" } ] } ], "protein_names": [ { "name": "ETS-related transcription factor Elf-5", "type": "recommended", "evidence": [ { "id": "Q58DT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#names_and_taxonomy" } ] }, { "name": "E74-like factor 5 ESE-2a", "type": "synonym", "evidence": [ { "id": "NP_001019740", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" } ] }, { "name": "E74-like factor 5", "type": "synonym", "evidence": [ { "id": "Q58DT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#names_and_taxonomy" } ] }, { "name": "ETS-related transcription factor Elf-5", "type": "synonym", "evidence": [ { "id": "NP_001019740", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" } ] } ], "function": [ { "annotation": "Elf5 regulation in the trophectoderm", "evidence": [ { "database": "RefSeq", "id": "NP_001019740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" }, { "database": "PubMed", "id": "22020251", "url": "https://glygen.org/publication/PubMed/22020251" } ] }, { "annotation": "Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT] (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELF5", "url": "https://www.uniprot.org/uniprotkb/Q58DT0", "locus": { "chromosome": "15", "start_pos": 65020403, "end_pos": 65067035, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012460", "url": "https://www.ensembl.org/id/ENSBTAG00000012460" } ] } } ], "crossref": [ { "id": "Q58DT0", "url": "https://alphafold.ebi.ac.uk/entry/Q58DT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012460", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012460", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539420", "url": "https://www.ncbi.nlm.nih.gov/gene/539420", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539420", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539420", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSWTELF", "url": "https://omabrowser.org/oma/group/MSWTELF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5C6", "url": "https://www.orthodb.org/?gene=A0A3Q1M5C6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUI6", "url": "https://www.orthodb.org/?gene=A0A3Q1MUI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DT0", "url": "https://www.orthodb.org/?gene=Q58DT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5C6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5C6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5C6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUI6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUI6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AD59", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AD59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AD59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AD59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AQW7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AQW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCGMTQEEFMEAAGVCGEYLYFILQSIRSQGYSFFNDPDETKATLKDYADSSCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 255, "header": "sp|Q58DT0-1|ELF5_BOVIN Isoform 1 of ETS-related transcription factor Elf-5 OS=Bos taurus OX=9913 GN=ELF5 PE=2 SV=1 CANONICAL=Q58DT0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5C6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#A0A3Q1M5C6-1", "sequence": { "sequence": "MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTDADSSCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 160, "header": "tr|A0A3Q1M5C6-1|A0A3Q1M5C6_BOVIN Computationally mapped isoform of E74 like ETS transcription factor 5 OS=Bos taurus OX=9913 GN=ELF5 PE=3 SV=2 CANONICAL=Q58DT0-1" }, "locus": { "chromosome": "15", "start_pos": 65045549, "end_pos": 65020826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073080.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073080.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063479.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063479.2" } ] } }, { "isoform_ac": "A0A3Q1MUI6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#A0A3Q1MUI6-1", "sequence": { "sequence": "MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCGMTQEEFMEAAGVCGEYLYFILQSIRSQGQCPERGASRTGARIGTKP", "length": 137, "header": "tr|A0A3Q1MUI6-1|A0A3Q1MUI6_BOVIN Computationally mapped isoform of E74 like ETS transcription factor 5 OS=Bos taurus OX=9913 GN=ELF5 PE=3 SV=2 CANONICAL=Q58DT0-1" }, "locus": { "chromosome": "15", "start_pos": 65045549, "end_pos": 65033610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075147.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075147.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058543.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058543.2" } ] } }, { "isoform_ac": "A0AAF7AD59-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#A0AAF7AD59-1", "sequence": { "sequence": "MLWVMLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCGMTQEEFMEAAGVCGEYLYFILQSIRSQGYSFFNDPDETKATLKDYADSSCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 259, "header": "tr|A0AAF7AD59-1|A0AAF7AD59_BOVIN Computationally mapped isoform of ETS-related transcription factor Elf-5 OS=Bos taurus OX=9913 GN=ELF5 PE=3 SV=1 CANONICAL=Q58DT0-1" }, "locus": { "chromosome": "15", "start_pos": 65065564, "end_pos": 65020826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085107.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085107.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067305.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067305.2" } ] } }, { "isoform_ac": "A0AAF7AQW7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#A0AAF7AQW7-1", "sequence": { "sequence": "MTTSEDQSSAQPGRTSEQRVMLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCGMTQEEFMEAAGVCGEYLYFILQSIRSQGYSFFNDPDETKATLKDYADSSCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 275, "header": "tr|A0AAF7AQW7-1|A0AAF7AQW7_BOVIN Computationally mapped isoform of ETS-related transcription factor Elf-5 OS=Bos taurus OX=9913 GN=ELF5 PE=3 SV=1 CANONICAL=Q58DT0-1" }, "locus": { "chromosome": "15", "start_pos": 65066836, "end_pos": 65020826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074492.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074492.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073408.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073408.2" } ] } }, { "isoform_ac": "Q58DT0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT0/entry#Q58DT0-1", "sequence": { "sequence": "MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCGMTQEEFMEAAGVCGEYLYFILQSIRSQGYSFFNDPDETKATLKDYADSSCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 255, "header": "sp|Q58DT0-1|ELF5_BOVIN Isoform 1 of ETS-related transcription factor Elf-5 OS=Bos taurus OX=9913 GN=ELF5 PE=2 SV=1 CANONICAL=Q58DT0-1" }, "locus": { "chromosome": "15", "start_pos": 65045549, "end_pos": 65020826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016534.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016534.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016534.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016534.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Elf5 regulation in the trophectoderm.", "journal": "Developmental biology", "date": "2011-12-15", "authors": "Pearton David J, Broadhurst Ric, Donnison Martyn, Pfeffer Peter L", "evidence": [ { "database": "RefSeq", "id": "NP_001019740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019740" } ], "reference": [ { "type": "PubMed", "id": "22020251", "url": "https://glygen.org/publication/PubMed/22020251" } ] } ], "pathway": [ { "id": "bta:539420", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539420", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MET4-1", "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "Elf5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPTFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTTIKDYADSSCLKTSGIKSQDCHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 253 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6A588-1", "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "Elf5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLDSVTHSTFLPNASFCDPLMSWTDLFNNEEYYPAFEHQTAACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTAIKDYADSSCLKTSGIKSQDCHTRTNLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL", "length": 254 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZVP9-1", "protein_name": "E74 like ETS transcription factor 5", "gene_name": "ELF5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPVYLKITLLILPFHLQLMYRCLKVMLDSVTPSTFLSNTMVCDPLMSWTEIFGTTEDDYPTCDHQTDSDSFWTSIHPEHWSKHNVCEWLQFCCDQYKLDANCISFSHFNISGLQLCNMTQEEFLDAAGICGEYLYFILQNIRMHGTSFFTDLEETKLSNKDCDLLTKLPPDSGVPSSLLTLFCSSVPVRDKACMRAGGISSQECHSHGRTNLQSSHLWEFVRDLLLSPEENGGILEWEDRGQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQENKI", "length": 307 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SGT0-1", "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "ELF5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLDSVTHGTFLPNANFCDPLMSWTDLFSSEEYYPAFEHQTACDPYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKAAIKDYADSSCLKTSGIKSQDCHNHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 255 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VDK3-1", "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "Elf5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLDSVTHSTFLPNASFCDPLMPWTDLFSNEDYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTGIKDYADSSCLKTSGIKSQDCHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL", "length": 253 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKW6-1", "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "ELF5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSLPHSHRVMLDSVTHSTFLPNASFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYFILQNIRTQGYSFFNDAEESKATIKDYADSNCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL", "length": 265 }, "evidence": [ { "id": "Q58DT0", "url": "https://omabrowser.org/oma/group/Q58DT0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q58DT0", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DT0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 255, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DT0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DT0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" }, { "id": "PRU00237", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00237" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000255", "start_pos": 163, "end_pos": 244, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT0" }, { "id": "PRU00762", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PNT", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 119, "start_aa": "Tyr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHX1-1", "uniprot_ac": "Q3MHX1", "uniprot_id": "COMD7_BOVIN", "mass": { "chemical_mass": 22534.0, "monoisotopic_mass": 22534.0 }, "refseq": { "ac": "NP_001030368", "name": "COMM domain-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030368" }, "gene_names": [ { "name": "COMMD7", "type": "recommended", "evidence": [ { "id": "Q3MHX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ] }, { "name": "COMMD7", "type": "synonym", "evidence": [ { "id": "NP_001030368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030368" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 7", "type": "recommended", "evidence": [ { "id": "Q3MHX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001030368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030368" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1#function" }, { "database": "UniProtKB", "id": "Q86VX2", "url": "https://www.uniprot.org/uniprotkb/Q86VX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD7", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1", "locus": { "chromosome": "13", "start_pos": 62068373, "end_pos": 62130564, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016427", "url": "https://www.ensembl.org/id/ENSBTAG00000016427" } ] } } ], "crossref": [ { "id": "Q3MHX1", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016427", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04755", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04755", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514295", "url": "https://www.ncbi.nlm.nih.gov/gene/514295", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514295", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514295", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SQQWGEH", "url": "https://omabrowser.org/oma/group/SQQWGEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBW9", "url": "https://www.orthodb.org/?gene=A0A3Q1MBW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHX1", "url": "https://www.orthodb.org/?gene=Q3MHX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21672", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21672", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030368", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBW9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBW9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4L0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4L0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4L0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFS", "length": 200, "header": "sp|Q3MHX1-1|COMD7_BOVIN Isoform 1 of COMM domain-containing protein 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=2 SV=1 CANONICAL=Q3MHX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0A3Q1MBW9-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIVVAHEPVAHEGSSRTRH", "length": 192, "header": "tr|A0A3Q1MBW9-1|A0A3Q1MBW9_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=2 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62079191, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083263.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083263.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067817.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067817.2" } ] } }, { "isoform_ac": "A0AAA9S0N9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0AAA9S0N9-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKLPARDGASQNQHGVFQLISVPALHLHPHPPPPPPLSR", "length": 189, "header": "tr|A0AAA9S0N9-1|A0AAA9S0N9_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62103032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091923.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091923.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077204.1" } ] } }, { "isoform_ac": "A0AAA9T4L0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0AAA9T4L0-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIGSSVHGILQARMLEWSAIPFSRGSS", "length": 200, "header": "tr|A0AAA9T4L0-1|A0AAA9T4L0_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62100357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119616.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119616.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090664.1" } ] } }, { "isoform_ac": "A0AAA9TUB1-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0AAA9TUB1-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIEHRLQGVWTSAVVVHGLSCSEACEIFLDQGSNPYPPHW", "length": 213, "header": "tr|A0AAA9TUB1-1|A0AAA9TUB1_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62068479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135428.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135428.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102194.1" } ] } }, { "isoform_ac": "A0AAA9TW86-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0AAA9TW86-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIGCSVELTLE", "length": 184, "header": "tr|A0AAA9TW86-1|A0AAA9TW86_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62072658, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101443.1" } ] } }, { "isoform_ac": "A0AAA9U2G9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#A0AAA9U2G9-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQSTGSRACGLQQLWCTGLVALRHVKSSWTRDRTPTPHIGRWILYHRATKKPQVPLSYRFIFVTCF", "length": 223, "header": "tr|A0AAA9U2G9-1|A0AAA9U2G9_BOVIN Computationally mapped isoform of COMM domain containing 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=4 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62068400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120172.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120172.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103705.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103705.1" } ] } }, { "isoform_ac": "Q3MHX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1/entry#Q3MHX1-1", "sequence": { "sequence": "MGRLHCTQDPVPEAVGGDMQQLNQLSAQQFSALTEVLFHFLTEPKEVERFLAQLSEFAATNQISLGPLRSIVKSLLLVPNGALKKGLTAEQVRADFMTLGLSEEKAIYFSEKWKQNAPTLARWAVGQTLMINQLVDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFS", "length": 200, "header": "sp|Q3MHX1-1|COMD7_BOVIN Isoform 1 of COMM domain-containing protein 7 OS=Bos taurus OX=9913 GN=COMMD7 PE=2 SV=1 CANONICAL=Q3MHX1-1" }, "locus": { "chromosome": "13", "start_pos": 62130536, "end_pos": 62103094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021846.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021846.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021846.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021846.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514295", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514295", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LV51-1", "protein_name": "COMM domain containing 7", "gene_name": "Commd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLYIQGLPGRDLESYWDAQSGSWNPAAARALSRDRRLGVWRKCGCGSAARPGRRKRAPLPGCGAPGTMGRLHCTQDPVPEAVRGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGPLKSIMKSLLLVPNGALKKGLTAEQVRTDLLTLGLSEEKATYFSEKWKQNAPTLAQWAIGQTLMINQLIDMEWRFGVTSGSSELEKVGSIFLQLKLVVKKGKQTENLYIASCTRWRESERAWSASADPVSPMATPGSQLPWEARCKEFLKPRVSVLEESCPILM", "length": 297 }, "evidence": [ { "id": "Q3MHX1", "url": "https://omabrowser.org/oma/group/Q3MHX1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86I14-1", "protein_name": "COMM domain-containing protein 7", "gene_name": "commd7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVFRFLGNNNNNNNELPDQQLINEIGYLSNFSNEQLEQLLDIIFEFMIIQKSEQLLNQIQEFSNEHSINENTLKNIIRGCIIFFKSSAKNNLTIDHLREDCIQFKLDEEQSKLVSTKYKQHYIEISRSLVGNSLTINQVLDMQWRFGVTTSSSEFTKSNTTGSTFLQLKLVLDKGNNIKEDVHMELTLPQFYEFLKEMQSAKASLEYFN", "length": 209 }, "evidence": [ { "id": "Q3MHX1", "url": "https://omabrowser.org/oma/group/Q3MHX1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86VX2-1", "protein_name": "COMM domain-containing protein 7", "gene_name": "COMMD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFC", "length": 200 }, "evidence": [ { "id": "Q3MHX1", "url": "https://omabrowser.org/oma/group/Q3MHX1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BG94-1", "protein_name": "COMM domain-containing protein 7", "gene_name": "Commd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRLHCTQDPVPEAVRGDMQQLNQLGAQQFSDLTEVLFHFLTEPKEVERFLAQLSEFATSNQISLGPLKSIMKSLLLVPNGALKKGLTAEQVRTDLQTLGLSEEKATYFSEKWKQNASTLAQWAMGQTLMVNQLIDMEWRFGVTSGSSELEKVGSIFLQLKLVVKKGKQTENLYMELTLPQFYSFLHEMERVRASMECLS", "length": 200 }, "evidence": [ { "id": "Q3MHX1", "url": "https://omabrowser.org/oma/group/Q3MHX1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "Q3MHX1", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 200, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHX1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX1" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 133, "end_pos": 200, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 168, "end_pos": 170 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W7-1", "uniprot_ac": "Q2T9W7", "uniprot_id": "MSPD1_BOVIN", "mass": { "chemical_mass": 24226.0, "monoisotopic_mass": 24226.0 }, "refseq": { "ac": "NP_001033226", "name": "motile sperm domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033226" }, "gene_names": [ { "name": "MOSPD1", "type": "recommended", "evidence": [ { "id": "Q2T9W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ] }, { "name": "MOSPD1", "type": "synonym", "evidence": [ { "id": "NP_001033226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033226" } ] } ], "protein_names": [ { "name": "Motile sperm domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q2T9W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7/entry#names_and_taxonomy" } ] }, { "name": "motile sperm domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033226" } ] } ], "function": [ { "annotation": "Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7#function" }, { "database": "UniProtKB", "id": "Q8VEL0", "url": "https://www.uniprot.org/uniprotkb/Q8VEL0#function" }, { "database": "UniProtKB", "id": "A0A3Q1MC94", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC94#function" }, { "database": "UniProtKB", "id": "ARBA00045707", "url": "https://www.uniprot.org/uniprotkb/ARBA00045707#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOSPD1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7", "locus": { "chromosome": "X", "start_pos": 18574679, "end_pos": 18598914, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013922", "url": "https://www.ensembl.org/id/ENSBTAG00000013922" } ] } } ], "crossref": [ { "id": "Q2T9W7", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523578", "url": "https://www.ncbi.nlm.nih.gov/gene/523578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523578", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYNPYEF", "url": "https://omabrowser.org/oma/group/VYNPYEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC94", "url": "https://www.orthodb.org/?gene=A0A3Q1MC94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2T9W7", "url": "https://www.orthodb.org/?gene=Q2T9W7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34441", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34441", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34441:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34441:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00635", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00635", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033226", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC94", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC94-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCMDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRIKEHLTESLFFEQSFQPENRTVSSGPSLLTVFLAVVCITALMLPTLGDVESLVPLYLHLSVNQKLVAAYILGLITMAIFRT", "length": 213, "header": "sp|Q2T9W7-1|MSPD1_BOVIN Isoform 1 of Motile sperm domain-containing protein 1 OS=Bos taurus OX=9913 GN=MOSPD1 PE=2 SV=1 CANONICAL=Q2T9W7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC94-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7/entry#A0A3Q1MC94-1", "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCMDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRIKEHLTESLFFEQSFQPGLITMAIFRT", "length": 159, "header": "tr|A0A3Q1MC94-1|A0A3Q1MC94_BOVIN Computationally mapped isoform of Motile sperm domain-containing protein 1 OS=Bos taurus OX=9913 GN=MOSPD1 PE=4 SV=2 CANONICAL=Q2T9W7-1" }, "locus": { "chromosome": "X", "start_pos": 18585959, "end_pos": 18576438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080437.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080437.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067946.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067946.2" } ] } }, { "isoform_ac": "Q2T9W7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7/entry#Q2T9W7-1", "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCMDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRIKEHLTESLFFEQSFQPENRTVSSGPSLLTVFLAVVCITALMLPTLGDVESLVPLYLHLSVNQKLVAAYILGLITMAIFRT", "length": 213, "header": "sp|Q2T9W7-1|MSPD1_BOVIN Isoform 1 of Motile sperm domain-containing protein 1 OS=Bos taurus OX=9913 GN=MOSPD1 PE=2 SV=1 CANONICAL=Q2T9W7-1" }, "locus": { "chromosome": "X", "start_pos": 18585959, "end_pos": 18576438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018489.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018489.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018489.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018489.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523578", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523578", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YV69-1", "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "MOSPD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQQQRRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYAVVDATGAVKPQCCVDIVIRHRDVRASHYGVIDKFRLQVSEQSQRKALGRKEIIATLLPSAKEPPQQKEEEEKRIKEHLSESVFFEQTLCQPGKNRPASSGPSLLTVFLGIVCIAALMLPTLGEMESLVPLYLHLSVNQKLVAAYVLGLITMVILRT", "length": 217 }, "evidence": [ { "id": "Q2T9W7", "url": "https://omabrowser.org/oma/group/Q2T9W7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5RJS6-1", "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "Mospd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVIDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVIATLLPSAKEQQKEEEEKRIKEHLTESVFFEQSCQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDMESLVPLYLHLSVNQKLVAAYILGLITMAILRT", "length": 213 }, "evidence": [ { "id": "Q2T9W7", "url": "https://omabrowser.org/oma/group/Q2T9W7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VEL0-1", "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "Mospd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVIATLLPSAKEQQKEEEEKRIKEHLTESVFFEQSCQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDMESLVPLYLHLSVNQKLVAAYILGLITMAILRT", "length": 213 }, "evidence": [ { "id": "Q2T9W7", "url": "https://omabrowser.org/oma/group/Q2T9W7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJG1-1", "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "MOSPD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRLKEHLTESLFFEQSFQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDVESLVPLYLHLSVNQKLVAAYILGLITMAILRT", "length": 213 }, "evidence": [ { "id": "Q2T9W7", "url": "https://omabrowser.org/oma/group/Q2T9W7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W7", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 213, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" }, { "id": "PRU00132", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MSP", "eco_id": "ECO_0000255", "start_pos": 16, "end_pos": 143, "start_aa": "Pro", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W7" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear export signal", "eco_id": "ECO_0000250", "start_pos": 205, "end_pos": 208, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBI8-1", "uniprot_ac": "Q2TBI8", "uniprot_id": "NUD22_BOVIN", "mass": { "chemical_mass": 31419.0, "monoisotopic_mass": 31419.0 }, "refseq": { "ac": "NP_001033769", "name": "uridine diphosphate glucose pyrophosphatase NUDT22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" }, "gene_names": [ { "name": "NUDT22", "type": "recommended", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ] }, { "name": "NUDT22", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] } ], "protein_names": [ { "name": "Uridine diphosphate glucose pyrophosphatase NUDT22", "type": "recommended", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.-", "type": "synonym", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside diphosphate-linked moiety X motif 22", "type": "synonym", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#names_and_taxonomy" } ] }, { "name": "Nudix motif 22", "type": "synonym", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#names_and_taxonomy" } ] }, { "name": "UDPG pyrophosphatase", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] }, { "name": "UGPPase", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] }, { "name": "nucleoside diphosphate-linked moiety X motif 22", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] }, { "name": "nudix (nucleoside diphosphate linked moiety X)-type motif 22", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] }, { "name": "nudix motif 22", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] }, { "name": "uridine diphosphate glucose pyrophosphatase NUDT22", "type": "synonym", "evidence": [ { "id": "NP_001033769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769" } ] } ], "function": [ { "annotation": "Pyrophosphatase hydrolyzing the diphosphate bond in the nucleotide-sugars UDP-glucose and UDP-galactose with a preference for the former, yielding glucose 1-phosphate or galactose 1-phosphate and UMP.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8#function" }, { "database": "UniProtKB", "id": "Q9BRQ3", "url": "https://www.uniprot.org/uniprotkb/Q9BRQ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT22", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8", "locus": { "chromosome": "29", "start_pos": 42534791, "end_pos": 42531517, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016559", "url": "https://www.ensembl.org/id/ENSBTAG00000016559" } ] } } ], "crossref": [ { "id": "Q2TBI8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016559", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016559", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533578", "url": "https://www.ncbi.nlm.nih.gov/gene/533578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533578", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCTDDGQ", "url": "https://omabrowser.org/oma/group/LCTDDGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCC3", "url": "https://www.orthodb.org/?gene=A0A3Q1MCC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJC3", "url": "https://www.orthodb.org/?gene=A0A452DJC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBI8", "url": "https://www.orthodb.org/?gene=Q2TBI8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31835", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31835", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31835:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31835:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001033769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033769", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29555", "url": "https://www.rhea-db.org/rhea/29555", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "86579", "url": "https://www.rhea-db.org/rhea/86579", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJC3", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPEVSLLLQCPPGGLPEKQVRAELSPAYDRRPLPGGDKAIIAIWESRLQAQPWLFNAPKFRLHSATLAPTGLPGPQLLLRLGLTSYQDFLGTNWASSAAWLRQQGATDWGDKQAYLADPLGVGAALATADDFLVFLRRSGQVAEAPGLVDVPGGHPEPQALCPGDSPLHKDLPGELVVHELFSSVLQEICDEVNVPPLTLSQPLLLGIACNETSAGRASAEFYVQCSLTSEQVRRHYMSGGPEAHESTGIIFVEKQSMQRLQETEMWPELCPSAKGAIFLYNRVQGSST", "length": 290, "header": "sp|Q2TBI8-1|NUD22_BOVIN Isoform 1 of Uridine diphosphate glucose pyrophosphatase NUDT22 OS=Bos taurus OX=9913 GN=NUDT22 PE=2 SV=1 CANONICAL=Q2TBI8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCC3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#A0A3Q1MCC3-1", "sequence": { "sequence": "MLPGVTEPQDLRAGRGIFRSLNSLPTPNSLEPIGKLRHSRQDLPKVTLCQPRVPGKLNPPDPGSLVCSARRASGGAAAIQAKVRNCLDRPDRRNRDRQEDSPTPGAGQLIRRGPERRDRPMRSRERRGQAFPLRGKGRSLRESGPNCPLQTMDPEVSLLLQCPPGGLPEKQVRAELSPAYDRRPLPGGDKAIIAIWESRLQAQPWLFNAPKFRLHSATLAPTGLPGPQLLLRLGLTSYQDFLGTNWASSAAWLRQQGATDWGDKQAYLADPLGVGAALATADDFLVFLRRSGQVAEAPGLVDVPGGHPEPQALCPGDSPLHKDLPGELVVHELFSSVLQEICDEVNVPPLTLSQPLLLGIACNETSAGRASAEFYVQCSLTSEQVRRHYMSGGPEAHESTGIIFVEKQSMQRLQETEMWPELCPSAKGAIFLYNRVQGSST", "length": 441, "header": "tr|A0A3Q1MCC3-1|A0A3Q1MCC3_BOVIN Computationally mapped isoform of Nudix hydrolase 22 OS=Bos taurus OX=9913 GN=NUDT22 PE=4 SV=2 CANONICAL=Q2TBI8-1" }, "locus": { "chromosome": "29", "start_pos": 42534726, "end_pos": 42531674, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078129.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078129.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067982.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067982.2" } ] } }, { "isoform_ac": "A0A452DJC3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#A0A452DJC3-1", "sequence": { "sequence": "MDPEVSLLLQCPPGGLPEKQVRAELSPAYDRRPLPGGDKAIIAIWESRLQAQPWLFNAPKFRLHSATLAPTGLPGPQLLLRLGLTSYQDFLGTNWASSAAWLRQQGATDWGDKQAYLADPLGVGAALATADDFLVFLRRSGQVAEAPGLVDVPGGHPEPQVRCQAGRRGTKTHKAQLCLPHLLKGELAWCFSKVNVPPLTLSQPLLLGIACNETSAGRASAEFYVQCSLTSEQVRRHYMSGGPEAHESTGIIFVEKQSMQRLQETEMWPELCPSAKGAIFLYNRVQGSST", "length": 290, "header": "tr|A0A452DJC3-1|A0A452DJC3_BOVIN Computationally mapped isoform of Nudix hydrolase 22 OS=Bos taurus OX=9913 GN=NUDT22 PE=4 SV=1 CANONICAL=Q2TBI8-1" }, "locus": { "chromosome": "29", "start_pos": 42534726, "end_pos": 42532520, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046035.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046035.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043364.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043364.4" } ] } }, { "isoform_ac": "Q2TBI8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8/entry#Q2TBI8-1", "sequence": { "sequence": "MDPEVSLLLQCPPGGLPEKQVRAELSPAYDRRPLPGGDKAIIAIWESRLQAQPWLFNAPKFRLHSATLAPTGLPGPQLLLRLGLTSYQDFLGTNWASSAAWLRQQGATDWGDKQAYLADPLGVGAALATADDFLVFLRRSGQVAEAPGLVDVPGGHPEPQALCPGDSPLHKDLPGELVVHELFSSVLQEICDEVNVPPLTLSQPLLLGIACNETSAGRASAEFYVQCSLTSEQVRRHYMSGGPEAHESTGIIFVEKQSMQRLQETEMWPELCPSAKGAIFLYNRVQGSST", "length": 290, "header": "sp|Q2TBI8-1|NUD22_BOVIN Isoform 1 of Uridine diphosphate glucose pyrophosphatase NUDT22 OS=Bos taurus OX=9913 GN=NUDT22 PE=2 SV=1 CANONICAL=Q2TBI8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:533578", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533578", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VYR2-1", "protein_name": "Nudix hydrolase 9", "gene_name": "NUDT9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAKLAEEMNPEGSRYQLLLSCPSGLSPSQVSVDFSKSHDRIPRQDPGLEDSISQVWEQRSQGNSSLFNGQKFRYGGYCLDDDDGSTNEVPHVCLRLGLTDYRTFVGTNLSSLWEKFLVTSEDDSVRCRHTSSPLGNGAVIETSDKKIIVLRRSNNVGEFPGHYVFPGGHPEPTAVGIDYHQLENNVQTGEVLNKKVTQEMFDSIICEVVEETGIPASSLSSPLFIGISRRELNVRPAMFFYLKCSHHSDDIQRLYSSAEDGFESTQLHTVSLDELKMMTSRMPGCHHGGFALYELMLQRLKNTKETSLIAT", "length": 311 }, "evidence": [ { "id": "Q2TBI8", "url": "https://omabrowser.org/oma/group/Q2TBI8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BRQ3-1", "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT22", "gene_name": "NUDT22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPEVTLLLQCPGGGLPQEQIQAELSPAHDRRPLPGGDEAITAIWETRLKAQPWLFDAPKFRLHSATLAPIGSRGPQLLLRLGLTSYRDFLGTNWSSSAAWLRQQGATDWGDTQAYLADPLGVGAALATADDFLVFLRRSRQVAEAPGLVDVPGGHPEPQALCPGGSPQHQDLAGQLVVHELFSSVLQEICDEVNLPLLTLSQPLLLGIARNETSAGRASAEFYVQCSLTSEQVRKHYLSGGPEAHESTGIFFVETQNVQRLLETEMWAELCPSAKGAIILYNRVQGSPTGAALGSPALLPPL", "length": 303 }, "evidence": [ { "id": "Q2TBI8", "url": "https://omabrowser.org/oma/group/Q2TBI8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "UDP-sugar diphosphatase activity", "id": "GO:0008768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008768", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "pmid": "" }, { "name": "GDP-mannose hydrolase activity", "id": "GO:0052751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052751", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI8", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29555", "name": "", "equation": "UDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + UMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q05B60-1", "Q2TBI8-1" ], "evidence": [ { "id": "29555", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29555" } ] }, { "id": "86579", "name": "", "equation": "UDP-alpha-D-galactose + H2O = alpha-D-galactose 1-phosphate + UMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBI8-1" ], "evidence": [ { "id": "86579", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/86579" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q05B60", "gene_name": "NUDT14", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q05B60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B60" } ] }, { "ec_number": "3.6.1.13", "activity": "ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+).", "evidence": [ { "id": "Q05B60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B60" } ] }, { "ec_number": "3.6.1.13", "activity": "", "evidence": [ { "id": "Q05B60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B60" } ] }, { "ec_number": "3.6.1.45", "activity": "UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.", "evidence": [ { "id": "Q05B60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B60" } ] }, { "ec_number": "3.6.1.45", "activity": "", "evidence": [ { "id": "Q05B60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B60" } ] } ] }, { "uniprot_ac": "Q2TBI8", "gene_name": "NUDT22", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBI8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nudix box", "eco_id": "ECO_0000250", "start_pos": 175, "end_pos": 196, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" }, { "id": "PRU00794", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00794" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000255", "start_pos": 118, "end_pos": 285, "start_aa": "Ala", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8#function" }, { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "binding_site_uniprot": 189, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 189, "end_pos": 189, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8#function" }, { "id": "Q2TBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI8" } ], "binding_site_uniprot": 193, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 193, "end_pos": 193, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W3-1", "uniprot_ac": "Q2T9W3", "uniprot_id": "CCD63_BOVIN", "mass": { "chemical_mass": 65966.0, "monoisotopic_mass": 65966.0 }, "refseq": { "ac": "NP_001069231", "name": "coiled-coil domain-containing protein 63", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069231" }, "gene_names": [ { "name": "CCDC63", "type": "recommended", "evidence": [ { "id": "Q2T9W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ] }, { "name": "CCDC63", "type": "synonym", "evidence": [ { "id": "NP_001069231", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069231" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 63", "type": "recommended", "evidence": [ { "id": "Q2T9W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 63", "type": "synonym", "evidence": [ { "id": "NP_001069231", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069231" } ] } ], "function": [ { "annotation": "Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3#function" }, { "database": "UniProtKB", "id": "Q8CDV6", "url": "https://www.uniprot.org/uniprotkb/Q8CDV6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC63", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3", "locus": { "chromosome": "17", "start_pos": 54705547, "end_pos": 54667570, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032353", "url": "https://www.ensembl.org/id/ENSBTAG00000032353" } ] } } ], "crossref": [ { "id": "Q2T9W3", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032353", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032353", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518001", "url": "https://www.ncbi.nlm.nih.gov/gene/518001", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR049258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518001", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518001", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMHKKTQ", "url": "https://omabrowser.org/oma/group/MMHKKTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9W3", "url": "https://www.orthodb.org/?gene=Q2T9W3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21694", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21694", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21694:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21694:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF21773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069231", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEH5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTKKHRRKDPESPQEPSEKTKEQLVEGELRKLRQQFRKMVDSRKSFNFRSQQKITNQRKEIKTLQEEQDEITLLLNLIKSSRNLDLNEKNYLELRFLLQTKEDYEALIKSMKLLLAELDEKIVQMEKKIINQRQIFTKIQEANNPRKLQKQIHILETRLNLVTVHFDQMLTTNAKLRKEIEDLRHEKAAYDNVYQHLRRRLLTKKKTMNVAIEQSAQAYEQRLEAMARMAAMKDRQQKDISQYNLEIRELERVYDHETKLKSFLLIKLNDRLEFEEQSKKEEALKAKKYGKKSKGASFESYEVAHLRLLKLTKTGNLNQLIEEFLAKEEKNFARFTYVTELNNDMEMMHKKIERIQNEILRLRSQQKSSHDDSYSILRELEEKLKKTTEEADMYENDYREITKTLEYLKNSVENLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLVLESYKRLMEMEVAEAEVQPSFLNPFWGGSALLKPAEPIKVIPPVLGADPLSDKLDEVEQPLDHSSLRQMVLSHYATRESRNRDSMPEKGDELKSKKKVTV", "length": 558, "header": "sp|Q2T9W3-1|CCD63_BOVIN Isoform 1 of Coiled-coil domain-containing protein 63 OS=Bos taurus OX=9913 GN=CCDC63 PE=1 SV=1 CANONICAL=Q2T9W3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEH5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3/entry#A0A3Q1MEH5-1", "sequence": { "sequence": "MPTKKHRRKDPESPQEPSEKTKEQLVEGELRKLRQQFRKMVDSRKSFNFRSQQKITNQRKEIKTLQEEQDEITLLLNLIKSSRNLDLNEKNYLELRFLLQTKEDYEALIKSMKLLLAELDEKNTEQGEAQPSSQVTVHFDQMLTTNAKLRKEIEDLRHEKAAYDNVYQHLRRRLLTKKKTMNVAIEQSAQAYEQRLEAMARMAAMKDRQQKDISQYNLEIRELERVYDHETKLKSFLLIKLNDRLEFEEQSKKEEALKAKKYGKKSKGASFESYEVAHLRLLKLTKTGNLNQLIEEFLAKEEKNFARFTYVTELNNDMEMMHKKIERIQNEILRLRSQQKSSHDDSYSILRELEEKLKKTTEEADMYENDYREITKTLEYLKNSVENLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLVLESYKRLMEMEVAEAEVQPSFLNPFWGGSALLKPAEPIKVIPPVLGADPLSDKLDEVEQPLDHSSLRQMVLSHYATRESRNRDSMPEKGDELKSKKKVTV", "length": 530, "header": "tr|A0A3Q1MEH5-1|A0A3Q1MEH5_BOVIN Computationally mapped isoform of Coiled-coil domain containing 63 OS=Bos taurus OX=9913 GN=CCDC63 PE=4 SV=1 CANONICAL=Q2T9W3-1" }, "locus": { "chromosome": "17", "start_pos": 54705486, "end_pos": 54675572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076036.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076036.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069414.1" } ] } }, { "isoform_ac": "Q2T9W3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3/entry#Q2T9W3-1", "sequence": { "sequence": "MPTKKHRRKDPESPQEPSEKTKEQLVEGELRKLRQQFRKMVDSRKSFNFRSQQKITNQRKEIKTLQEEQDEITLLLNLIKSSRNLDLNEKNYLELRFLLQTKEDYEALIKSMKLLLAELDEKIVQMEKKIINQRQIFTKIQEANNPRKLQKQIHILETRLNLVTVHFDQMLTTNAKLRKEIEDLRHEKAAYDNVYQHLRRRLLTKKKTMNVAIEQSAQAYEQRLEAMARMAAMKDRQQKDISQYNLEIRELERVYDHETKLKSFLLIKLNDRLEFEEQSKKEEALKAKKYGKKSKGASFESYEVAHLRLLKLTKTGNLNQLIEEFLAKEEKNFARFTYVTELNNDMEMMHKKIERIQNEILRLRSQQKSSHDDSYSILRELEEKLKKTTEEADMYENDYREITKTLEYLKNSVENLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLVLESYKRLMEMEVAEAEVQPSFLNPFWGGSALLKPAEPIKVIPPVLGADPLSDKLDEVEQPLDHSSLRQMVLSHYATRESRNRDSMPEKGDELKSKKKVTV", "length": 558, "header": "sp|Q2T9W3-1|CCD63_BOVIN Isoform 1 of Coiled-coil domain-containing protein 63 OS=Bos taurus OX=9913 GN=CCDC63 PE=1 SV=1 CANONICAL=Q2T9W3-1" }, "locus": { "chromosome": "17", "start_pos": 54705486, "end_pos": 54675572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045892.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045892.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043247.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043247.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518001", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518001", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4V8F7-1", "protein_name": "Coiled-coil domain-containing protein 63", "gene_name": "Ccdc63", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKSSNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGDYEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNLVTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAYEQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQAKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARFTYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDIYENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKKTNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSDKVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR", "length": 559 }, "evidence": [ { "id": "Q2T9W3", "url": "https://omabrowser.org/oma/group/Q2T9W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CDV6-1", "protein_name": "Coiled-coil domain-containing protein 63", "gene_name": "Ccdc63", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKVRRKGSSGLSELSEKAREQLAQAELRKLRQQFRKMVDSRKSFNFRHQRMIAGQYKEIETLKAEQAETTMLLSLVKSPKNLDINQKNFMELRFLLQTKGDYEALISSMKVLLGELDDKIVQMERKITNQRQLFLRTQEANNPKRLQRQIHVLESRLNLVTVHFDTMLTSNSQLRKEIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSAQAYEQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHETKLKSFLLAKLNDRSEFEDQAKKQEDVKSKKLGKKGKGESFASYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARFTYVTELNNDMETMHKKTQRIQDDIINLRSQQQTSHEGTRSILKQMEEKLRKTTQEADIYETKYKEMSKTLEYLKNSVEKMFKKINCDATEILGKLGESGKVTDINLQQYFAIIEKKTNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPIRVVLPVFGADSFSDKLEEVDSPLDHSTLQQMVLENFLQRERTKELQDTMSEKGDEIRLKKKVIG", "length": 558 }, "evidence": [ { "id": "Q2T9W3", "url": "https://omabrowser.org/oma/group/Q2T9W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NA47-1", "protein_name": "Coiled-coil domain-containing protein 63", "gene_name": "CCDC63", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAEIPPPFINPFWGGSALLKPPEPIKVIPPVLGADPFSDRLDDVEQPLDHSSLRQLVLDNYILKENRSKEVRGDSLPEKVDDFRSRKKVTM", "length": 563 }, "evidence": [ { "id": "Q2T9W3", "url": "https://omabrowser.org/oma/group/Q2T9W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ], "pmid": "" }, { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 558, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZU0-1", "uniprot_ac": "Q3SZU0", "uniprot_id": "GTSF1_BOVIN", "mass": { "chemical_mass": 19146.0, "monoisotopic_mass": 19146.0 }, "refseq": { "ac": "NP_001029445", "name": "gametocyte-specific factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029445" }, "gene_names": [ { "name": "GTSF1", "type": "recommended", "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ] }, { "name": "FAM112B", "type": "synonym", "evidence": [ { "id": "NP_001029445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029445" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ] }, { "name": "GTSF1", "type": "synonym", "evidence": [ { "id": "NP_001029445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029445" } ] } ], "protein_names": [ { "name": "Gametocyte-specific factor 1", "type": "recommended", "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM112B", "type": "synonym", "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0/entry#names_and_taxonomy" } ] }, { "name": "gametocyte-specific factor 1", "type": "synonym", "evidence": [ { "id": "NP_001029445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029445" } ] } ], "function": [ { "annotation": "Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "database": "UniProtKB", "id": "Q9DAN6", "url": "https://www.uniprot.org/uniprotkb/Q9DAN6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTSF1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0", "locus": { "chromosome": "5", "start_pos": 25629603, "end_pos": 25615176, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018085", "url": "https://www.ensembl.org/id/ENSBTAG00000018085" } ] } } ], "crossref": [ { "id": "Q3SZU0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018085", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018085", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506864", "url": "https://www.ncbi.nlm.nih.gov/gene/506864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506864", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506864", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TANFCGN", "url": "https://omabrowser.org/oma/group/TANFCGN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEW9", "url": "https://www.orthodb.org/?gene=A0A3Q1MEW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZU0", "url": "https://www.orthodb.org/?gene=Q3SZU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029445", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEW9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEW9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZU0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEETYIDTLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRSLGQETMAESTWRCPPCDEDWDKDLWEQTSTPFVWGTANYCGNNSPASNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ", "length": 167, "header": "sp|Q3SZU0-1|GTSF1_BOVIN Isoform 1 of Gametocyte-specific factor 1 OS=Bos taurus OX=9913 GN=GTSF1 PE=2 SV=1 CANONICAL=Q3SZU0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0/entry#A0A3Q1MEW9-1", "sequence": { "sequence": "KEKTYLDTLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRSLGQETMAESTWRCPPCDEDWDKDLWEQTSTPFVWGTANYCGNNSPASNIVMEHKSNLASGMRVPKSLPYVLPWKNSK", "length": 164, "header": "tr|A0A3Q1MEW9-1|A0A3Q1MEW9_BOVIN Computationally mapped isoform of Gametocyte specific factor 1 OS=Bos taurus OX=9913 GN=GTSF1 PE=4 SV=2 CANONICAL=Q3SZU0-1" }, "locus": { "chromosome": "5", "start_pos": 25625800, "end_pos": 25620816, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080902.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080902.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069055.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069055.2" } ] } }, { "isoform_ac": "Q3SZU0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0/entry#Q3SZU0-1", "sequence": { "sequence": "MEETYIDTLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRSLGQETMAESTWRCPPCDEDWDKDLWEQTSTPFVWGTANYCGNNSPASNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ", "length": 167, "header": "sp|Q3SZU0-1|GTSF1_BOVIN Isoform 1 of Gametocyte-specific factor 1 OS=Bos taurus OX=9913 GN=GTSF1 PE=2 SV=1 CANONICAL=Q3SZU0-1" }, "locus": { "chromosome": "5", "start_pos": 25627253, "end_pos": 25615208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047442.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047442.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044649.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506864", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506864", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1WAD5-1", "protein_name": "Gametocyte specific factor 1", "gene_name": "GTSF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEETYIDSLDPEKLIQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPPCDEDWDKDLWEQTSTTFVWGTANYCGNNSPASNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ", "length": 167 }, "evidence": [ { "id": "Q3SZU0", "url": "https://omabrowser.org/oma/group/Q3SZU0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8WW33-1", "protein_name": "Gametocyte-specific factor 1", "gene_name": "GTSF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPWKNNGNAQ", "length": 167 }, "evidence": [ { "id": "Q3SZU0", "url": "https://omabrowser.org/oma/group/Q3SZU0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAN6-1", "protein_name": "Gametocyte-specific factor 1", "gene_name": "Gtsf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDTYIDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTASFCGNNSPANNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ", "length": 167 }, "evidence": [ { "id": "Q3SZU0", "url": "https://omabrowser.org/oma/group/Q3SZU0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" }, { "name": "secondary piRNA processing", "id": "GO:0140965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140965", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" }, { "name": "piRNA-mediated gene silencing by mRNA destabilization", "id": "GO:0140991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140991", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "piP-body", "id": "GO:0071547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071547", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU0", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZU0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 167, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZU0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZU0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 17, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 17, "end_pos": 17, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 23, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 23, "end_pos": 23, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 33, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 33, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 37, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 37, "end_pos": 37, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 51, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 51, "end_pos": 51, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 57, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 57, "end_pos": 57, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 67, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 67, "end_pos": 67, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0#function" }, { "id": "Q3SZU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU0" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 71, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 71, "end_pos": 71, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDJ2-1", "uniprot_ac": "Q2YDJ2", "uniprot_id": "SC22C_BOVIN", "mass": { "chemical_mass": 34133.0, "monoisotopic_mass": 34133.0 }, "refseq": { "ac": "NP_001040011", "name": "vesicle-trafficking protein SEC22c", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040011" }, "gene_names": [ { "name": "SEC22C", "type": "recommended", "evidence": [ { "id": "Q2YDJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" } ] }, { "name": "SEC22C", "type": "synonym", "evidence": [ { "id": "NP_001040011", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040011" } ] } ], "protein_names": [ { "name": "Vesicle-trafficking protein SEC22c", "type": "recommended", "evidence": [ { "id": "Q2YDJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2/entry#names_and_taxonomy" } ] }, { "name": "SEC22 vesicle trafficking protein homolog C", "type": "synonym", "evidence": [ { "id": "NP_001040011", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040011" } ] }, { "name": "SEC22 vesicle-trafficking protein homolog C", "type": "synonym", "evidence": [ { "id": "Q2YDJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2/entry#names_and_taxonomy" } ] }, { "name": "vesicle-trafficking protein SEC22c", "type": "synonym", "evidence": [ { "id": "NP_001040011", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040011" } ] } ], "function": [ { "annotation": "May be involved in vesicle transport between the ER and the Golgi complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MF73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF73#function" }, { "database": "UniProtKB", "id": "ARBA00003595", "url": "https://www.uniprot.org/uniprotkb/ARBA00003595#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC22C", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2", "locus": { "chromosome": "22", "start_pos": 14704398, "end_pos": 14723145, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006570", "url": "https://www.ensembl.org/id/ENSBTAG00000006570" } ] } } ], "crossref": [ { "id": "Q2YDJ2", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006570", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006570", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14824", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14824", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614905", "url": "https://www.ncbi.nlm.nih.gov/gene/614905", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043546", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043546", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614905", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614905", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDRTNDC", "url": "https://omabrowser.org/oma/group/QDRTNDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MF73", "url": "https://www.orthodb.org/?gene=A0A3Q1MF73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2YDJ2", "url": "https://www.orthodb.org/?gene=Q2YDJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46258:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46258:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25970", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040011", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLILFACVVRVRDGLPLSASTDFYHSQDFLECRRRLKTLALRLAQYPGRGSAEGCDFSIHFSSSRDVACMAICSLQCPAAMAFCFLETLWWEFTASYDTTCVGLASRPYAFLEFDNVIQKVKWHFNYVSSTQMDSSLGKIQEELKFQPPVVLTLEDTDVANGVMNGHTLMHLEPAPSFRMEPVTALGILSLILNIMCAALNLIRGIHLAEHSLQVAHEEIGNILAFLIPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNVYLHGLRNLWQILFHIGVAFLSSHQILTRQLQDKQSDCGV", "length": 303, "header": "sp|Q2YDJ2-1|SC22C_BOVIN Isoform 1 of Vesicle-trafficking protein SEC22c OS=Bos taurus OX=9913 GN=SEC22C PE=2 SV=1 CANONICAL=Q2YDJ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MF73-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2/entry#A0A3Q1MF73-1", "sequence": { "sequence": "MSLILFACVVRVRDGLPLSASTDFYHSQDFLECRRRLKTLALRLAQYPGRASLFPCPAAMAFCFLETLWWEFTASYDTTCVGLASRPYAFLEFDNVIQKVKWHFNYVSSTQMDSSLGKIQEELKFQPPVVLTLEDTDVANGVMNGHTLMHLEPAPSFRMEPVTALGILSLILNIMCAALNLIRGIHLAEHSLQVAHEEIGNILAFLIPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNVYLHGLRNLWQILFHIGVAFLSSHQILTRQLQDKQSDCGV", "length": 281, "header": "tr|A0A3Q1MF73-1|A0A3Q1MF73_BOVIN Computationally mapped isoform of SEC22 homolog C, vesicle trafficking protein OS=Bos taurus OX=9913 GN=SEC22C PE=3 SV=1 CANONICAL=Q2YDJ2-1" }, "locus": { "chromosome": "22", "start_pos": 14716602, "end_pos": 14704741, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082726.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082726.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072834.1" } ] } }, { "isoform_ac": "Q2YDJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2/entry#Q2YDJ2-1", "sequence": { "sequence": "MSLILFACVVRVRDGLPLSASTDFYHSQDFLECRRRLKTLALRLAQYPGRGSAEGCDFSIHFSSSRDVACMAICSLQCPAAMAFCFLETLWWEFTASYDTTCVGLASRPYAFLEFDNVIQKVKWHFNYVSSTQMDSSLGKIQEELKFQPPVVLTLEDTDVANGVMNGHTLMHLEPAPSFRMEPVTALGILSLILNIMCAALNLIRGIHLAEHSLQVAHEEIGNILAFLIPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNVYLHGLRNLWQILFHIGVAFLSSHQILTRQLQDKQSDCGV", "length": 303, "header": "sp|Q2YDJ2-1|SC22C_BOVIN Isoform 1 of Vesicle-trafficking protein SEC22c OS=Bos taurus OX=9913 GN=SEC22C PE=2 SV=1 CANONICAL=Q2YDJ2-1" }, "locus": { "chromosome": "22", "start_pos": 14716602, "end_pos": 14704741, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008631.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008631.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008631.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008631.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614905", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614905", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJP5-1", "protein_name": "Vesicle-trafficking protein SEC22c", "gene_name": "SEC22C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSMILFACVVRVRDGLPLSASTDFYHTQDFLECRRRLKTLALRLAQYPGRGSAKGRDFSIHFSSSRDVACMAICSHQCPSAMAFYFLETLWWEFTASYDTTCIGLASRPYAFLEFDSVIQKVKWHFNYVSSTQMENSLEKIQEDLKFQPPVVLTLEDTDVANGVMNGHTRMHLEPAPNFRMEPVTALGVLSLILNIMCAALNLIRGIHLAEHSLQVAHEEIGNILAFLIPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSHQILTRQLQEKQSDCGV", "length": 303 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1ABL7-1", "protein_name": "SEC22 homolog C, vesicle trafficking protein", "gene_name": "SEC22C", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSMIFFACVVRVRDGLPLSASTDFHFNQDFLECRKKLKALSSVLARYPSRGTAKGRDLSIHFLSSGEIACMAICSSSYSTIMAFCFLEELQWAFAASYDTTSINLASRPYAFLEFDNAIQKVKHRFNYMSGSATKVSWEKVEEELRLQPPVQLKLEDAELMNGMANGGHAGVHVEVAPAYRMQRVTPLGILSLVLNIMCGALNLIRGVHLAEHSFQEDYEGIGNVVAFFLPFLACVFQCYLYLYYSSTRKVKTFVLFFSVCLCNIYLYGLRNLWQIAFHIGVASLSSYQILTRQLMEKQPDCGV", "length": 304 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FXZ0-1", "protein_name": "Vesicle-trafficking protein SEC22c isoform X1", "gene_name": "Sec22c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPMILFASVVRVRDGLPLSASTDFYHAQEFLECRRQLKALARRLPQYPGRGSAESRDFNIYFSSSGGVACMAICSRQCPAAMVFCFLETLWWDFTASYDTTCIGLASRPYAFLEFDSVIQKTKWRFNHMSSSQMKSGLEKIQEELELQPPAMLSIEGTDVANGMLNGHTPVHSEPAPNLRMEPVTALGVLSLVLNILCAALNLVRGVHLAEHSLQVAQEEVGNILAFFIPSVACIVQSSQDSEGGADSGLHLPGQHVPARAEEHLASPLSHRSGFSVLVSDPDQTAAGEAVRLWSVRTASRSERSL", "length": 306 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9QFN4-1", "protein_name": "Vesicle-trafficking protein SEC22c isoform X1", "gene_name": "sec22c", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLILFAFVVRVRDGLPLSASTDFLHNKELQEKKQQIKIISKSLNVLPERGTVKGHELNIHFLSCEGVSYMSVCACTLPAATAFCFLEDLRWEFTACFDNSAVAMANRPYPFLEFDSAIQKLQQHYNQKGGPSLEVTLAEVQEDLRSSPPQVLTMEDVVLSNGAANGHVEQTTASGQSQRLEPVSAPGILSLVLNIMCAALNLIRGVHLIEYTFQDDYDGLWNVVAFLVAFLCCVCQCHLYLFHTCQKRLKSFTLLTLIVLCNAFLFGPRNIWQLVFHLSVACLSTLLTLHRKLQDRNTDCGV", "length": 303 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BXT9-1", "protein_name": "Vesicle-trafficking protein SEC22c", "gene_name": "Sec22c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMILFASIVRVRDGLPLSASTDFYYAQEFLECRRQLKTLAQRLARHPGRGCAESCDFLIYFSSSGDVACMAICSRQCPAAMAFCFLEALWWDFIASYDTTCVGLASRPYAFLEFDSVIQKTKWHFNHMSSSQMKSGLEKIQEELEFQPPAVLSLEDTDVANGMLNGHTPVHSEPAPNLRMKPVTALGVLSLVLNIMCAALNLIRGVHLAEHSLQVAQEEVGNILAFFIPSVACIVQCYLYLFYSPARTLKVLLMLASICLGNAYLHGLRNTWQILFHVGVAFLSSYQILTRQLQERQSDYGV", "length": 303 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BRL7-1", "protein_name": "Vesicle-trafficking protein SEC22c", "gene_name": "SEC22C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQKVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDVANGVMNGHTPMHLEPAPNFRMEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAHEEIGNILAFLVPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSYQILTRQLQEKQSDCGV", "length": 303 }, "evidence": [ { "id": "Q2YDJ2", "url": "https://omabrowser.org/oma/group/Q2YDJ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ2", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDJ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDJ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDJ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ2" }, { "id": "PRU00231", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00231" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Longin", "eco_id": "ECO_0000255", "start_pos": 8, "end_pos": 119, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHJ7-1", "uniprot_ac": "Q3MHJ7", "uniprot_id": "EEPD1_BOVIN", "mass": { "chemical_mass": 62787.0, "monoisotopic_mass": 62787.0 }, "refseq": { "ac": "NP_001029581", "name": "endonuclease/exonuclease/phosphatase family domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029581" }, "gene_names": [ { "name": "EEPD1", "type": "recommended", "evidence": [ { "id": "Q3MHJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ] }, { "name": "EEPD1", "type": "synonym", "evidence": [ { "id": "NP_001029581", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029581" } ] } ], "protein_names": [ { "name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3MHJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7/entry#names_and_taxonomy" } ] }, { "name": "endonuclease/exonuclease/phosphatase family domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029581", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029581" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EEPD1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7", "locus": { "chromosome": "4", "start_pos": 60949047, "end_pos": 61070778, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019065", "url": "https://www.ensembl.org/id/ENSBTAG00000019065" } ] } } ], "crossref": [ { "id": "Q3MHJ7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHJ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10283", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10283", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511767", "url": "https://www.ncbi.nlm.nih.gov/gene/511767", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511767", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511767", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HLVPANT", "url": "https://omabrowser.org/oma/group/HLVPANT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJ07", "url": "https://www.orthodb.org/?gene=A0A3Q1MJ07", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHJ7", "url": "https://www.orthodb.org/?gene=Q3MHJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21180:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21180:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029581", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ07", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ07-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHJ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLMAEQQPHHLATAAAVPLTPRVNINTATPAQLMSVRGLTEKMAVSIVDYRREHGPFRSVEDLVRMGGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCVELNQPILPNIRKWKGPRGCWKAVVSETPSTQLQKGAGFAGFLWDTAAGVELRDAAWQESSPGNGHGKPVGPSPYLARFKVGSHDLTLVNLHLATLTLPGGENLSKNHSDSHRWASFTQTLQETLKGEKDVIVLGDFGQGPDSSDYDILRKEKFHHLIPAHTFTNISTKNPQGSKALDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWTRKEGPRSGNGLTLERSEANIKHER", "length": 571, "header": "sp|Q3MHJ7-1|EEPD1_BOVIN Isoform 1 of Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Bos taurus OX=9913 GN=EEPD1 PE=2 SV=1 CANONICAL=Q3MHJ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJ07-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7/entry#A0A3Q1MJ07-1", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLMAEQQPHHLATAAAVPLTPRVNINTATPAQLMSVRGLTEKMAVSIVDYRREHGPFRSVEDLVRMGGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKGAGFAGFLWDTAAGVELRDAAWQESSPGNGHGKPVGPSPYLARFKVGSHDLTLVNLHLATLTLPGGENLSKNHSDSHRWASFTQTLQETLKGEKDVIVLGDFGQGPDSSDYDILRKEKFHHLIPAHTFTNISTKNPQGSKALDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWTRKEGPRSGNGLTLERSEANIKHER", "length": 534, "header": "tr|A0A3Q1MJ07-1|A0A3Q1MJ07_BOVIN Computationally mapped isoform of Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Bos taurus OX=9913 GN=EEPD1 PE=4 SV=1 CANONICAL=Q3MHJ7-1" }, "locus": { "chromosome": "4", "start_pos": 61069757, "end_pos": 60949519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074169.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074169.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070737.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070737.1" } ] } }, { "isoform_ac": "Q3MHJ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7/entry#Q3MHJ7-1", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLMAEQQPHHLATAAAVPLTPRVNINTATPAQLMSVRGLTEKMAVSIVDYRREHGPFRSVEDLVRMGGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCVELNQPILPNIRKWKGPRGCWKAVVSETPSTQLQKGAGFAGFLWDTAAGVELRDAAWQESSPGNGHGKPVGPSPYLARFKVGSHDLTLVNLHLATLTLPGGENLSKNHSDSHRWASFTQTLQETLKGEKDVIVLGDFGQGPDSSDYDILRKEKFHHLIPAHTFTNISTKNPQGSKALDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWTRKEGPRSGNGLTLERSEANIKHER", "length": 571, "header": "sp|Q3MHJ7-1|EEPD1_BOVIN Isoform 1 of Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Bos taurus OX=9913 GN=EEPD1 PE=2 SV=1 CANONICAL=Q3MHJ7-1" }, "locus": { "chromosome": "4", "start_pos": 61069757, "end_pos": 60949519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033712.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033712.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033621.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033621.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser106" }, { "start_pos": 110, "end_pos": 110, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser110" }, { "start_pos": 162, "end_pos": 162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser162" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser16" }, { "start_pos": 175, "end_pos": 175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser175" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser21" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser25" }, { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Thr267" }, { "start_pos": 430, "end_pos": 430, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "site_lbl": "Ser430" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511767", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511767", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQI4-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "EEPD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATSVPLTPRVNINTATPAQLMSVRGLTEKMAISIVDYRREHGPFRSVEDLVRMGGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPILPNIRKWKGPRGCWKVVVSETPSTQLPKGAGFAGFLWDVTAGVELRDAAWQESSPGNGHGKPAGPSPYLARFKVGSHDLTLVNLHLAALTLPGGENPSKNHSDGHRWASFTQTLQESLKGEKDVIVLGDFGQGPDSSDYDILRKEKFHPLIPAHTFTNISTKNPQGSKTLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDGSRKEGPRNSSGVTLEPSEANIKHER", "length": 569 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z915-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "EEPD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGNLGCHRSIPRDPADLCHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVAQNIVEYREYIGGFKKVEDLALVSGVGAAKLEQVKFEICVSSKGSSAQHSPSSLRKDPASEHHLSATKININTATPAQLMSIRGITEKIANSIVDYRKEHGPFKSIEDLVRMNCINSSFLDKIRHQIFAERSRPPSTNTNGGVNFTAKPHPSPTSLSLQSEDLDFPPGGPTQIISTRPSVEMFGGLRDGRPVLRVATWNLQSCSIEKANNPGVREVICMTLLENSIKLLAVQELLDREALEKFCMELNQPTLPNIRKWKGPRGCWKGVVSEKPSGQLPKGVEYCGFLWDTTAGIELKDASSQENVQTNGNGRHSYPHPYIAHFKVGMNDLTLVNLHLALAPAVGDNAGKNHDSHKLATFAQTLQETLKGEKDVIILGDFNQAADSSDHDILRKEKFHHLVPSNTFTNISTKNPQGSKSLDNMWISRSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASDHCPVLAEFYMEKDWNRKEVTRNGNGVTVERDSNTKHER", "length": 558 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HTJ3-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "Eepd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHNRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGNSAQHSPSSLRRDLLAEQQPHHLATSVPLTPRVNINTATLAQLMSIRGLTEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISMRPSVEAFGGMRDGRPVFRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDKEALEKFCTELNQPILPNIRKWKGSRGCWRSVIAEKPSSQLQKGACYSGFLWDTAASVELRDIPGQESSPSNGHGKAVGPSPFLARFKVGSNDLTLVNLQLTALALPGAENPSKNHGDGHRLLNFALTLQETLKGEKDVVILGDFGQGPDSSDCDILRREKFHHVIPAHTFTNISTRNPQGSKSVDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAELYMEKDWSKKEVPRNGNGVTLERSEANIKHER", "length": 569 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TGW2-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "Eepd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHNRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGNSAQHSPSSLRRDLLAEQQPHHLTTTVPLTPRVNINTATLAQLMSVRGLSEKMALSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISMRPSVEAFGGMRDGRPVFRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDKEALEKFCTELNQPILPNIRKWKGSRGCWRSIVAEKPSNQLQKGPCYSGFLWDTAANVELRDIPGRESSPSNGHAKAVGPSPFLARFKVGSNDLTLVNLQLTALALPGAENSSKNHSDGHRLLNFALTLQETLKGEKDVVILGDFGQGPDSNDYDILRREKFHHLVPAHTFTNISTRNPQGSKSVDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAELYMEKDWSKKEVPRNGNGVTLEPSEANIKHER", "length": 569 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5XI74-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "Eepd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGNSAQHSPSSLRRDLLAEQQPHHLATTVPLTPRVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISMRPSVEAFGGMRDGRPVFRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDKEALEKFCTELNQPILPNIRKWKGPRGCWRSIVAEKPSSQLQKGPCYSGFLWDTAANVELRDIPGQESSPSNGHAKTVGPSPFLARFKVGSNDLTLVNLQLTALALPGVENSSKNHSDGHRLLNFALTLQETLKGEKDVVILGDFGQGPDSSDYDILRREKFHHLIPAHTFTNISTRNPQGSKSVDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAELYMEKDWSKKEVPRNGNGVTLEPSEANVKHER", "length": 569 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7L9B9-1", "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "EEPD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSSQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER", "length": 569 }, "evidence": [ { "id": "Q3MHJ7", "url": "https://omabrowser.org/oma/group/Q3MHJ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "pmid": "" }, { "name": "positive regulation of cholesterol efflux", "id": "GO:0010875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010875", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHJ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 571, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHJ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHJ7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 16, 21, 25, 106, 110, 162, 175, 267, 430 ], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 523, "end_pos": 525 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CW5-1", "uniprot_ac": "Q58CW5", "uniprot_id": "SERC2_BOVIN", "mass": { "chemical_mass": 50425.0, "monoisotopic_mass": 50425.0 }, "refseq": { "ac": "XP_024856908", "name": "serine incorporator 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856908" }, "gene_names": [ { "name": "SERINC2", "type": "recommended", "evidence": [ { "id": "Q58CW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ] }, { "name": "SERINC2", "type": "synonym", "evidence": [ { "id": "XP_024856908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856908" } ] }, { "name": "TDE2L", "type": "synonym", "evidence": [ { "id": "XP_024856908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856908" }, { "id": "Q58CW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ] } ], "protein_names": [ { "name": "Serine incorporator 2", "type": "recommended", "evidence": [ { "id": "Q58CW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#names_and_taxonomy" } ] }, { "name": "Tumor differentially expressed protein 2-like", "type": "synonym", "evidence": [ { "id": "Q58CW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#names_and_taxonomy" } ] }, { "name": "serine incorporator 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024856908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856908" } ] } ], "function": [ { "annotation": "Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. In contrast to SERINC3 and SERINC5, has no effect on gammaretrovirus particles infectivity.", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5#function" }, { "database": "UniProtKB", "id": "Q96SA4", "url": "https://www.uniprot.org/uniprotkb/Q96SA4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERINC2", "url": "https://www.uniprot.org/uniprotkb/Q58CW5", "locus": { "chromosome": "2", "start_pos": 122233163, "end_pos": 122253524, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035081", "url": "https://www.ensembl.org/id/ENSBTAG00000035081" } ] } } ], "crossref": [ { "id": "Q58CW5", "url": "https://alphafold.ebi.ac.uk/entry/Q58CW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035081", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035081", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513593", "url": "https://www.ncbi.nlm.nih.gov/gene/513593", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ECCESEK", "url": "https://omabrowser.org/oma/group/ECCESEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10383:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-977347", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977347", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024856908", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38571", "url": "https://www.rhea-db.org/rhea/38571", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38663", "url": "https://www.rhea-db.org/rhea/38663", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38895", "url": "https://www.rhea-db.org/rhea/38895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MJ93", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ93-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CW5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGACLGACSLLSCASCLCGSAPCILCSCCPCSHNSTLSRLFFTVFLFLGVLVCVIMLSPGVESQLYKLPWVCNEGTGSHVVLQGHIDCGSLLGHRAVYRMCFAMAAFFFLFSLLMVCVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNIWFYFGVVGSFIFLLIQLLLLIDFAHSWNQRWLCKAEECDSRAWYAGLFFFTLLFYALSITAVALLFVYYTQPGACYEGKVFIGLNLTLCVCVSIVAILPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNGTVLAGPEGYETHWWDAPSIVGLVVFILCTVFISLRSSDHRQVNSLMQTEECPPVLDATQQQVVSEGRAFDNEQDGVTYSYSFFHLCLVLASVHIMMTLTNWYRPGETRKMISTWTAVWVKICASWTGLLLYLWTLVAPLLLPNRDFS", "length": 452, "header": "sp|Q58CW5-1|SERC2_BOVIN Isoform 1 of Serine incorporator 2 OS=Bos taurus OX=9913 GN=SERINC2 PE=2 SV=1 CANONICAL=Q58CW5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJ93-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#A0A3Q1MJ93-1", "sequence": { "sequence": "PCSHNSTLSRLFFTVFLFLGVLVCVIMLSPGVESQLYKLPWVCNEGTGSHVVLQGHIDCGSLLGHRAVYRMCFAMAAFFFLFSLLMVCVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNSRWPWWGGMGATKRNKHWWVLLFVPRRQDSGAWPCGLFFFTLLFYALSITAVALLFVYYTQPGACYEGKVFIGLNLTLCVCVSIVAILPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNGTVLAGPEGYETHWWDAPSIVGLVVFILCTVFISLRSSDHRQVNSLMQTEECPPVLDATQQQVVSEGRAFDNEQDGVTYSYSFFHLCLVLASVHIMMTLTNWYRPGETRKMISTWTAVWVKICASWTGLLLYLWTLVAPLLLPNRDFS", "length": 412, "header": "tr|A0A3Q1MJ93-1|A0A3Q1MJ93_BOVIN Computationally mapped isoform of Serine incorporator 2 OS=Bos taurus OX=9913 GN=SERINC2 PE=3 SV=3 CANONICAL=Q58CW5-1" }, "locus": { "chromosome": "2", "start_pos": 122241412, "end_pos": 122233609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076014.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076014.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070834.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070834.3" } ] } }, { "isoform_ac": "A0AAA9T6X3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#A0AAA9T6X3-1", "sequence": { "sequence": "MKVKSEREVAQSCPTLSDPMNCSLPGSSIHGMSTSRQEYWSRVPLPSPGIEPRSPYFQTITLYPDVSPVARLARQLESPVPPLSLWSSPAHLPQASCLCGSAPCILCSCCPCSHNSTLSRLFFTVFLFLGVLVCVIMLSPGVESQLYKLPWVCNEGTGSHVVLQGHIDCGSLLGHRAVYRMCFAMAAFFFLFSLLMVCVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNIWFYFGVVGSFIFLLIQLLLLIDFAHSWNQRWLCKAEECDSRAWYAGLFFFTLLFYALSITAVALLFVYYTQPGACYEGKVFIGLNLTLCVCVSIVAILPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNGTVLAGPEGYETHWWDAPSIVGLVVFILCTVFISLRSSDHRQVNSLMQTEECPPVLDATQQQVVSEGRAFDNEQDGVTYSYSFFHLCLVLASVHIMMTLTNWYRPGETRKMISTWTAVWVKICASWTGLLLYLWTLVAPLLLPNRDFS", "length": 533, "header": "tr|A0AAA9T6X3-1|A0AAA9T6X3_BOVIN Computationally mapped isoform of Serine incorporator 2 OS=Bos taurus OX=9913 GN=SERINC2 PE=3 SV=1 CANONICAL=Q58CW5-1" }, "locus": { "chromosome": "2", "start_pos": 122249698, "end_pos": 122233609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124199.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124199.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094518.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094518.1" } ] } }, { "isoform_ac": "A0AAF6DLM5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#A0AAF6DLM5-1", "sequence": { "sequence": "MDGRMMRRMRLKEEEAPGPGNTASCLCGSAPCILCSCCPCSHNSTLSRLFFTVFLFLGVLVCVIMLSPGVESQLYKLPWVCNEGTGSHVVLQGHIDCGSLLGHRAVYRMCFAMAAFFFLFSLLMVCVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNIWFYFGVVGSFIFLLIQLLLLIDFAHSWNQRWLCKAEECDSRAWYAGLFFFTLLFYALSITAVALLFVYYTQPGACYEGKVFIGLNLTLCVCVSIVAILPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNGTVLAGPEGYETHWWDAPSIVGLVVFILCTVFISLRSSDHRQVNSLMQTEECPPVLDATQQQVVSEGRAFDNEQDGVTYSYSFFHLCLVLASVHIMMTLTNWYRPGETRKMISTWTAVWVKICASWTGLLLYLWTLVAPLLLPNRDFS", "length": 461, "header": "tr|A0AAF6DLM5-1|A0AAF6DLM5_BOVIN Computationally mapped isoform of Serine incorporator 2 OS=Bos taurus OX=9913 GN=SERINC2 PE=3 SV=1 CANONICAL=Q58CW5-1" }, "locus": { "chromosome": "2", "start_pos": 122253343, "end_pos": 122233609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015387.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015387.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015387.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015387.6" } ] } }, { "isoform_ac": "Q58CW5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW5/entry#Q58CW5-1", "sequence": { "sequence": "MGACLGACSLLSCASCLCGSAPCILCSCCPCSHNSTLSRLFFTVFLFLGVLVCVIMLSPGVESQLYKLPWVCNEGTGSHVVLQGHIDCGSLLGHRAVYRMCFAMAAFFFLFSLLMVCVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNIWFYFGVVGSFIFLLIQLLLLIDFAHSWNQRWLCKAEECDSRAWYAGLFFFTLLFYALSITAVALLFVYYTQPGACYEGKVFIGLNLTLCVCVSIVAILPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNGTVLAGPEGYETHWWDAPSIVGLVVFILCTVFISLRSSDHRQVNSLMQTEECPPVLDATQQQVVSEGRAFDNEQDGVTYSYSFFHLCLVLASVHIMMTLTNWYRPGETRKMISTWTAVWVKICASWTGLLLYLWTLVAPLLLPNRDFS", "length": 452, "header": "sp|Q58CW5-1|SERC2_BOVIN Isoform 1 of Serine incorporator 2 OS=Bos taurus OX=9913 GN=SERINC2 PE=2 SV=1 CANONICAL=Q58CW5-1" }, "locus": { "chromosome": "2", "start_pos": 122249245, "end_pos": 122233609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057114.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "R-BTA-977347", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977347", "resource": "Reactome", "description": "Serine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480TQ97-1", "protein_name": "Serine incorporator 2", "gene_name": "SERINC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGACLGACSLLSCASCLCGSAPCILCSCCPCSHNSTLSRLIFTAFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGTGSTVILQGHIDCGSLLGHRAVYRMCFAMAAFFFLFTLLMICVRSSRDPRAAIQNGFWFFKFLIFVGITVGAFYIPDGSFSNIWFYFGVAGSFVFFLIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYALSITAVALLFVYYTQPDACYESKVFIGLNLTLCVCVSIVAVLPKIQDAQPNSGLLQASVITLYTMFVTWLALSNVPDQKCNPHLLTHFGNWTALAGHEGYETQWWDAPSIVGLVVFILCTLFISLRSSDHRQVNSLMQTEECPPVLEATQQQQVTVSEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYRPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAPLLLPNRDFS", "length": 454 }, "evidence": [ { "id": "Q58CW5", "url": "https://omabrowser.org/oma/group/Q58CW5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q1LXL6-1", "protein_name": "Serine incorporator 2 precursor", "gene_name": "serinc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGACMALCSLASCASCLCGSAPCLLSGCCPSTYNSTVTRLAFSFFLLLGTIVSIIMILPGMETQLKKIPGFCEGGSSIPGFEGKVNCDVIVGYKSVYRMCFAMACFFFLFSIIMIRVRSSKDPRAAIQNGFWFFKFLILVGITVGAFFIPDGMFNTVWYYFGVVGSFIFILIQLILLVDFAHSWNQKWVENAEDGNSKCWYAALLSFTLVHYICAFAAVVLFYIFYTQPDDCTENKVFISLNLIFCIIVSVVAILPKVQEAQPSSGLLQASLISLYTMYLTWSAMSNNPNRKCNPSLLSIVKGQSAAPTPTSTPGVFTQWWDAQSVVGLVIFLLCTLYASIRSSNNSQVNKLMQTEEVQGLASSDANDAISEDGVRRAVDNEEDGVTYGYSFFHFSLFLASLYIMMTLTNWYQPETDYAAMTTTMPSVWVKICSSWLGLGLYLWTLVAPLVLTDRDFN", "length": 458 }, "evidence": [ { "id": "Q58CW5", "url": "https://omabrowser.org/oma/group/Q58CW5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q4FZV1-1", "protein_name": "Serine incorporator 2", "gene_name": "Serinc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALVKFKSRFISKSLLWFSIQSELRVGLGCAPVVAGLFPISASLGKVWRQHLSQVSPTRSRALPESDERLRQVGRGRGGDGLGVGPVKAPRVPPDPGSEAGAPRPAPRTAMGACLGACSLLSCASCLCGSAPCILCSCCPSTRNSTVSRLLFTGFLFLGVLVSIIMLSPGVESQLYKLPWVCEDRAQQPVVLQGPLDCGSLLGFRAVYRMCFATAAFFFLFMMLMICVRSSRDPRAAIQNGFWFFKFLILVGITVGAFYIPDGSFPKIWFYFGVVGSFLFILIQLILFIDFAHSWNQRWLCKAEECDSPVWYAGLFFFTFLFYLLSIAAVALMFVYYTESGACHEGKVFIGLNLTFCVCVSIIAVLPKVQSAQPNSGLLQASVVTLYTMFVTWSALSNVPDQKCNPHLPTKNGTGQVNLEDYSTVWWDAPSIVGLVIFILCTFFISLRSSDHRQVNSLMQTEECPAEMVQQQQVAVGDGRTYDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYSPGETRKMISTWTSVWVKICASWAGLFLYLWTLVAPLLLPNRDFS", "length": 560 }, "evidence": [ { "id": "Q58CW5", "url": "https://omabrowser.org/oma/group/Q58CW5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0E7-1", "protein_name": "Serine incorporator 2", "gene_name": "Serinc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGACLGACSLLSCASCLCGSAPCILCGCCPSTRNSTVSRLLFTSFLFLGVLVSIIMLSPGVESQLYKLPWVCEDRTQQPLVLQGPLDCGSLLGFRAVYRMCFATAAFFFFFMLLMICVRSSRDPRAAIQNGFWFFKFLILVGITVGAFYIPDGSFPKIWFYFGVVGSFLFILIQLILFVDFAHSWNQRWLCKAEECDSPAWYAGLFFFTFLFYLLSIAAVALMFVYYTESGACHEGKVFISLNLTFCVCVSIIAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSNVPDQKCNPHLPTKNGTGQVDLEDYSTVWWDAPSIVGLVIFILCTFFISLRSSDHRQVNSLMQTEECPAEMVQQQQVAVSDGRAYDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYSPGETRKMISTWTSVWVKICASWAGLFLYLWTLVAPLLLPNRDFS", "length": 450 }, "evidence": [ { "id": "Q58CW5", "url": "https://omabrowser.org/oma/group/Q58CW5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96SA4-1", "protein_name": "Serine incorporator 2", "gene_name": "SERINC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGACLGACSLLSCASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAPLLLRNRDFS", "length": 455 }, "evidence": [ { "id": "Q58CW5", "url": "https://omabrowser.org/oma/group/Q58CW5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "plasma membrane phospholipid scrambling", "id": "GO:0017121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017121", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phospholipid scramblase activity", "id": "GO:0017128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "database": "UniProtKB", "id": "Q58CW5", "url": "https://www.uniprot.org/uniprotkb/Q58CW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38571", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38571", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38571" } ] }, { "id": "38663", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MUP9-1" ], "evidence": [ { "id": "38663", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38663" } ] }, { "id": "38895", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38895" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CW5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 452, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CW5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CW5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 }, { "start_pos": 304, "end_pos": 306 }, { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2TBJ0-1", "uniprot_ac": "Q2TBJ0", "uniprot_id": "NOPC1_BOVIN", "mass": { "chemical_mass": 20946.0, "monoisotopic_mass": 20946.0 }, "refseq": { "ac": "NP_001033778", "name": "NOP protein chaperone 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" }, "gene_names": [ { "name": "NOPCHAP1", "type": "recommended", "evidence": [ { "id": "Q2TBJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ] }, { "name": "C12orf45", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] }, { "name": "C5H12orf45", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] }, { "name": "NOPCHAP1", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] } ], "protein_names": [ { "name": "NOP protein chaperone 1", "type": "recommended", "evidence": [ { "id": "Q2TBJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#names_and_taxonomy" } ] }, { "name": "NOP protein chaperone 1", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] }, { "name": "chromosome 5 C12orf45 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] }, { "name": "uncharacterized protein C12orf45 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778" } ] } ], "function": [ { "annotation": "Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0#function" }, { "database": "UniProtKB", "id": "Q8N5I9", "url": "https://www.uniprot.org/uniprotkb/Q8N5I9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOPCHAP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0", "locus": { "chromosome": "5", "start_pos": 68539158, "end_pos": 68528021, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021196", "url": "https://www.ensembl.org/id/ENSBTAG00000021196" } ] } } ], "crossref": [ { "id": "Q2TBJ0", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021196", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021196", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616791", "url": "https://www.ncbi.nlm.nih.gov/gene/616791", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616791", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616791", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HEFDIEH", "url": "https://omabrowser.org/oma/group/HEFDIEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBJ0", "url": "https://www.orthodb.org/?gene=Q2TBJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28674", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28674", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28674:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28674:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033778", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJM5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJM5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVSGESHSGPSCSSSSRDGSGVSVSKELLMAGSGGRGGIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEGEVTIDNIKLPHSEDGKGKIEVLDSPASENKEKQENK", "length": 192, "header": "sp|Q2TBJ0-1|NOPC1_BOVIN Isoform 1 of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=2 SV=1 CANONICAL=Q2TBJ0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJM5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#A0A3Q1MJM5-1", "sequence": { "sequence": "MEVSGESHSGPSCSSSSRDGSGVSVSKELLMAGSGGRGGIWDRLFINSKPNSRKNSTLQTVRIERSP", "length": 67, "header": "tr|A0A3Q1MJM5-1|A0A3Q1MJM5_BOVIN Computationally mapped isoform of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=4 SV=2 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68530362, "end_pos": 68528052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074941.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074941.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074592.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074592.2" } ] } }, { "isoform_ac": "A0AAA9SJD5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#A0AAA9SJD5-1", "sequence": { "sequence": "MAGSRKSRTSCGTFLWLGVRRFATPWTAALQASLSFTISQSFLKLMSVESMMPSNHLILCRPLLLLPSIFLSIRVFSSIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEGEVTIDNIKLPHSEDGKGKIEVLDSPASENKEKQENK", "length": 231, "header": "tr|A0AAA9SJD5-1|A0AAA9SJD5_BOVIN Computationally mapped isoform of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=4 SV=1 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68535900, "end_pos": 68528752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130490.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130490.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085445.1" } ] } }, { "isoform_ac": "A0AAA9T7Z0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#A0AAA9T7Z0-1", "sequence": { "sequence": "GVHKALGFESKSCSLCSDGLESWEVCVCVFAGIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEGEVTIDNIKLPHSEDGKGKIEVLDSPASENKEKQENK", "length": 185, "header": "tr|A0AAA9T7Z0-1|A0AAA9T7Z0_BOVIN Computationally mapped isoform of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=4 SV=1 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68535900, "end_pos": 68529669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095441.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095441.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092906.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092906.1" } ] } }, { "isoform_ac": "A0AAA9T9C3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#A0AAA9T9C3-1", "sequence": { "sequence": "MEVSGESHSGPSCSSSSRDGSGVSVSKELLMAGSGGRGGIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEVQFSRSVMSDSLRPHELQHARPPCPSPNPGVHPNPCPSSR", "length": 195, "header": "tr|A0AAA9T9C3-1|A0AAA9T9C3_BOVIN Computationally mapped isoform of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=4 SV=1 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68537944, "end_pos": 68528052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106644.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106644.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093219.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093219.1" } ] } }, { "isoform_ac": "A0AAA9TF94-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#A0AAA9TF94-1", "sequence": { "sequence": "MEVSGESHSGPSCSSSSRDGSGVSVSKELLMAGSGGRGGIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEAFSTVSWKLSHRHALVGLTLCILCLILRCKVTAAI", "length": 190, "header": "tr|A0AAA9TF94-1|A0AAA9TF94_BOVIN Computationally mapped isoform of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=4 SV=1 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68538955, "end_pos": 68528052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103318.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103318.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096794.1" } ] } }, { "isoform_ac": "Q2TBJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0/entry#Q2TBJ0-1", "sequence": { "sequence": "MEVSGESHSGPSCSSSSRDGSGVSVSKELLMAGSGGRGGIWDRLFINSKPNSRKNSTLQTVRIERSPLLDQVRTFLPQMAQANEKLRKEMAAAPPGHFNIENTDETLGQVIQMDVALFEMNQSHSKEEDSSEENSQDSSEESSESEDEDDSTSSEGEVTIDNIKLPHSEDGKGKIEVLDSPASENKEKQENK", "length": 192, "header": "sp|Q2TBJ0-1|NOPC1_BOVIN Isoform 1 of NOP protein chaperone 1 OS=Bos taurus OX=9913 GN=NOPCHAP1 PE=2 SV=1 CANONICAL=Q2TBJ0-1" }, "locus": { "chromosome": "5", "start_pos": 68535900, "end_pos": 68528052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028244.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028244.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028244.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028244.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "site_lbl": "Ser180" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "site_lbl": "Ser34" }, { "start_pos": 66, "end_pos": 66, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "site_lbl": "Ser66" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616791", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616791", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M6B3-1", "protein_name": "NOP protein chaperone 1", "gene_name": "Nopchap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRGEHASGPGVSSSSVDCSRITVSRELLTAGSEGSRGVWDQLLINSKPHSRKASTLQTVRVQRSPLLDQVQAFLPQMAQANEKLRKEMAVAPAGHFNIENIDETSGNIIQMDVALFEMNQSEDSKEDDNPEESSQDSSGDSSESEDDDCIPSEVTIENIKLPNTEGGKGKIQVLDSPASKKKKQ", "length": 186 }, "evidence": [ { "id": "Q2TBJ0", "url": "https://omabrowser.org/oma/group/Q2TBJ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LPE1-1", "protein_name": "NOP protein chaperone 1", "gene_name": "NOPCHAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVQSESQSGPTCSSSSQNHSGVSVSKELLTAGSGDQGGIWDKLLINSKPNSRKNSTLQTVRIERSPLLDRVQTFLPQMAQANEQLRKEMAAAPPGCFNIENIDETLGKVIQMDVALFEMNPSDSKEEDSSEENSQDSSASEDEDDSTSSEGEITIDNIKLPHSEAGKGKIEVLDSPDSEKKETGK", "length": 186 }, "evidence": [ { "id": "Q2TBJ0", "url": "https://omabrowser.org/oma/group/Q2TBJ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N5I9-1", "protein_name": "NOP protein chaperone 1", "gene_name": "NOPCHAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVHGKPKASPSCSSPTRDSSGVPVSKELLTAGSDGRGGIWDRLLINSQPKSRKTSTLQTVRIERSPLLDQVQTFLPQMARANEKLRKEMAAAPPGRFNIENIDGPHSKVIQMDVALFEMNQSDSKEVDSSEESSQDSSENSSESEDEDDSIPSEVTIDNIKLPNSEGGKGKIEVLDSPASKKKK", "length": 185 }, "evidence": [ { "id": "Q2TBJ0", "url": "https://omabrowser.org/oma/group/Q2TBJ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CX66-1", "protein_name": "NOP protein chaperone 1", "gene_name": "Nopchap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEFQGERGTGPGVSSSSVACSQVTVSRELLTAGSEGSGGIWDQLLISSKPHPRKTSTLQTVRMQRSPLLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVALFEMSRSDSKEEDSPEESSRDSSGDSSESEEDVCVPSEVTIENIKLPNAEGGKGKIEILDSPASKKKKQ", "length": 185 }, "evidence": [ { "id": "Q2TBJ0", "url": "https://omabrowser.org/oma/group/Q2TBJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "box C/D snoRNP assembly", "id": "GO:0000492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000492", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "box C/D methylation guide snoRNP complex binding", "id": "GO:0062064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062064", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ0", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBJ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 192, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBJ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBJ0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 34, 66, 180 ], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JZ9-1", "uniprot_ac": "Q56JZ9", "uniprot_id": "GMFG_BOVIN", "mass": { "chemical_mass": 16770.0, "monoisotopic_mass": 16770.0 }, "refseq": { "ac": "NP_001019708", "name": "glia maturation factor gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019708" }, "gene_names": [ { "name": "GMFG", "type": "recommended", "evidence": [ { "id": "Q56JZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ] }, { "name": "GMFG", "type": "synonym", "evidence": [ { "id": "NP_001019708", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019708" } ] } ], "protein_names": [ { "name": "Glia maturation factor gamma", "type": "recommended", "evidence": [ { "id": "Q56JZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#names_and_taxonomy" } ] }, { "name": "GMF-gamma", "type": "synonym", "evidence": [ { "id": "NP_001019708", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019708" }, { "id": "Q56JZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#names_and_taxonomy" } ] }, { "name": "glia maturation factor gamma", "type": "synonym", "evidence": [ { "id": "NP_001019708", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019708" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GMFG", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9", "locus": { "chromosome": "18", "start_pos": 49038393, "end_pos": 49053033, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005390", "url": "https://www.ensembl.org/id/ENSBTAG00000005390" } ] } } ], "crossref": [ { "id": "Q56JZ9", "url": "https://alphafold.ebi.ac.uk/entry/Q56JZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005390", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005390", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11283", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11283", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514407", "url": "https://www.ncbi.nlm.nih.gov/gene/514407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KYVHGDG", "url": "https://omabrowser.org/oma/group/KYVHGDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MK80", "url": "https://www.orthodb.org/?gene=A0A3Q1MK80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q56JZ9", "url": "https://www.orthodb.org/?gene=Q56JZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11249:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11249:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019708", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S592", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S592", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S592-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S592-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDSLVVCEVDPELKEKLRKFRFRKETDNAAIVMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLKEKLSFFR", "length": 142, "header": "sp|Q56JZ9-1|GMFG_BOVIN Isoform 1 of Glia maturation factor gamma OS=Bos taurus OX=9913 GN=GMFG PE=2 SV=1 CANONICAL=Q56JZ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MK80-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#A0A3Q1MK80-1", "sequence": { "sequence": "MGILRFGERDPELKEKLRKFRFRKETDNAAIVMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLKEKLSFFR", "length": 141, "header": "tr|A0A3Q1MK80-1|A0A3Q1MK80_BOVIN Computationally mapped isoform of Glia maturation factor OS=Bos taurus OX=9913 GN=GMFG PE=1 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49042964, "end_pos": 49038486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077671.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077671.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071256.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071256.1" } ] } }, { "isoform_ac": "A0AAA9RST7-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#A0AAA9RST7-1", "sequence": { "sequence": "MKIEPKKNVLRERALRAGTSRVKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLKEKLSFFR", "length": 130, "header": "tr|A0AAA9RST7-1|A0AAA9RST7_BOVIN Computationally mapped isoform of Glia maturation factor OS=Bos taurus OX=9913 GN=GMFG PE=1 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49052762, "end_pos": 49038486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097684.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097684.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074744.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074744.1" } ] } }, { "isoform_ac": "A0AAA9S592-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#A0AAA9S592-1", "sequence": { "sequence": "MNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLKEKLSFFR", "length": 93, "header": "tr|A0AAA9S592-1|A0AAA9S592_BOVIN Computationally mapped isoform of Glia maturation factor gamma OS=Bos taurus OX=9913 GN=GMFG PE=1 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49043249, "end_pos": 49038486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081111.1" } ] } }, { "isoform_ac": "A0AAA9SNA6-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#A0AAA9SNA6-1", "sequence": { "sequence": "MSDSLVVCEVDPELKEKLRKFRFRKETDNAAIVMKVDKDRQMVVLEEEFQVFEIRTTDDLTEAWLKEKLSFFR", "length": 73, "header": "tr|A0AAA9SNA6-1|A0AAA9SNA6_BOVIN Computationally mapped isoform of Glia maturation factor gamma OS=Bos taurus OX=9913 GN=GMFG PE=1 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49043249, "end_pos": 49038486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106723.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106723.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084327.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084327.1" } ] } }, { "isoform_ac": "A0AAA9SP97-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#A0AAA9SP97-1", "sequence": { "sequence": "MSDSLVVCEVDPELKEKLRKFRFRKETDNAAIVMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVWGRPKLLSVREESGIR", "length": 136, "header": "tr|A0AAA9SP97-1|A0AAA9SP97_BOVIN Computationally mapped isoform of Glia maturation factor OS=Bos taurus OX=9913 GN=GMFG PE=3 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49043249, "end_pos": 49038727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087182.1" } ] } }, { "isoform_ac": "Q56JZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9/entry#Q56JZ9-1", "sequence": { "sequence": "MSDSLVVCEVDPELKEKLRKFRFRKETDNAAIVMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHADGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLKEKLSFFR", "length": 142, "header": "sp|Q56JZ9-1|GMFG_BOVIN Isoform 1 of Glia maturation factor gamma OS=Bos taurus OX=9913 GN=GMFG PE=2 SV=1 CANONICAL=Q56JZ9-1" }, "locus": { "chromosome": "18", "start_pos": 49043249, "end_pos": 49038486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007090.3", "url": "https://www.ensembl.org/id/ENSBTAT00000007090.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000007090.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514407", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514407", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "O60234-1", "protein_name": "Glia maturation factor gamma", "gene_name": "GMFG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDSLVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLQEKLSFFR", "length": 142 }, "evidence": [ { "id": "Q56JZ9", "url": "https://omabrowser.org/oma/group/Q56JZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80T18-1", "protein_name": "Glia maturation factor gamma", "gene_name": "Gmfg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDSLVVCDVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDEFQNVSPEELKLELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQIAELTKVFEIRTTDDLNETWLKEKLAFFR", "length": 142 }, "evidence": [ { "id": "Q56JZ9", "url": "https://omabrowser.org/oma/group/Q56JZ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ERL7-1", "protein_name": "Glia maturation factor gamma", "gene_name": "Gmfg", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDSLVVCEVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDELQNISPEELKLELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTETWLKEKLAFFR", "length": 142 }, "evidence": [ { "id": "Q56JZ9", "url": "https://omabrowser.org/oma/group/Q56JZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin filament debranching", "id": "GO:0071846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071846", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "negative regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034316", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "Arp2/3 complex binding", "id": "GO:0071933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071933", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ9", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JZ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q56JZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ9" }, { "id": "PRU00599", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00599" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ADF-H", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 139, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T183-1", "uniprot_ac": "Q3T183", "uniprot_id": "PR15L_BOVIN", "mass": { "chemical_mass": 11378.0, "monoisotopic_mass": 11378.0 }, "refseq": { "ac": "NP_001029966", "name": "proline-rich protein 15-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" }, "gene_names": [ { "name": "PRR15L", "type": "recommended", "evidence": [ { "id": "Q3T183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T183" } ] }, { "name": "ATAD4", "type": "synonym", "evidence": [ { "id": "NP_001029966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" }, { "id": "Q3T183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T183" } ] }, { "name": "PRR15L", "type": "synonym", "evidence": [ { "id": "NP_001029966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" } ] } ], "protein_names": [ { "name": "Proline-rich protein 15-like protein", "type": "recommended", "evidence": [ { "id": "Q3T183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#names_and_taxonomy" } ] }, { "name": "ATPase family, AAA domain containing 4", "type": "synonym", "evidence": [ { "id": "NP_001029966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" } ] }, { "name": "Protein ATAD4", "type": "synonym", "evidence": [ { "id": "Q3T183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#names_and_taxonomy" } ] }, { "name": "proline-rich protein 15-like protein", "type": "synonym", "evidence": [ { "id": "NP_001029966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" } ] }, { "name": "protein ATAD4", "type": "synonym", "evidence": [ { "id": "NP_001029966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T183", "url": "https://www.uniprot.org/uniprotkb/Q3T183" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR15L", "url": "https://www.uniprot.org/uniprotkb/Q3T183", "locus": { "chromosome": "19", "start_pos": 38516837, "end_pos": 38500545, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012249", "url": "https://www.ensembl.org/id/ENSBTAG00000012249" } ] } } ], "crossref": [ { "id": "Q3T183", "url": "https://alphafold.ebi.ac.uk/entry/Q3T183", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012249", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012249", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616622", "url": "https://www.ncbi.nlm.nih.gov/gene/616622", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616622", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616622", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STGWWKL", "url": "https://omabrowser.org/oma/group/STGWWKL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MN41", "url": "https://www.orthodb.org/?gene=A0A3Q1MN41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T183", "url": "https://www.orthodb.org/?gene=Q3T183", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14581", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14581", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14581:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14581:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S181", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S181-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S181-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXE9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T183", "url": "https://www.uniprot.org/uniprotkb/Q3T183", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T183-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 100, "header": "sp|Q3T183-1|PR15L_BOVIN Isoform 1 of Proline-rich protein 15-like protein OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MN41-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0A3Q1MN41-1", "sequence": { "sequence": "VAVHAGEGSGLFGAWNRFTLTPGATAEQVPSCTCFSAPAAQLLLPSSPSLSLAWRGSPEAPPPPPVSRGAAPALSSFSREALASSLPAVGLTDNFICQNFHQLRQQLHGLVKGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 222, "header": "tr|A0A3Q1MN41-1|A0A3Q1MN41_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38510736, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071908.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071908.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072637.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072637.1" } ] } }, { "isoform_ac": "A0AAA9S181-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0AAA9S181-1", "sequence": { "sequence": "MLERGLASLGHGTGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 123, "header": "tr|A0AAA9S181-1|A0AAA9S181_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38510746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134095.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077072.1" } ] } }, { "isoform_ac": "A0AAA9SDG1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0AAA9SDG1-1", "sequence": { "sequence": "ASLCLLSREGLGFRFTLTPGATAEQVPSCTCFSAPAAQLLLPSSPSLSLAWRGSPEAPPPPPVSRGAAPALSSFSREALASSLPAVGLTDNFICQNFHQLRQQLHGLVKGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 219, "header": "tr|A0AAA9SDG1-1|A0AAA9SDG1_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38510992, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089415.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089415.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080362.1" } ] } }, { "isoform_ac": "A0AAA9SMY2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0AAA9SMY2-1", "sequence": { "sequence": "MVGAVLGCPHACQGANHHRHRVVGYPVRPCGFPSCANSGGVTCIFRADFYHPMDCKSPGQGPCPQCACSGPAKAGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 184, "header": "tr|A0AAA9SMY2-1|A0AAA9SMY2_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38511833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116819.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116819.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087707.1" } ] } }, { "isoform_ac": "A0AAA9T5Q9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0AAA9T5Q9-1", "sequence": { "sequence": "MLERGLASLGHGTDNFICQNFHQLRQQLHGLVKGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 143, "header": "tr|A0AAA9T5Q9-1|A0AAA9T5Q9_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38510746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123348.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123348.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092061.1" } ] } }, { "isoform_ac": "A0AAF6YXE9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#A0AAF6YXE9-1", "sequence": { "sequence": "VAVHAGEGSGLFGAWNRFTLTPGATAEQVPSCTCFSAPAAQLLLPSSPSLSLAWRGSPEAPPPPPVSRGAAPALSSFSREALASSLPAVGLTGSPTLRSGNAMTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 202, "header": "tr|A0AAF6YXE9-1|A0AAF6YXE9_BOVIN Computationally mapped isoform of Proline rich 15 like OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38510736, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016243.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016243.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016243.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016243.3" } ] } }, { "isoform_ac": "Q3T183-1", "url": "https://www.uniprot.org/uniprotkb/Q3T183/entry#Q3T183-1", "sequence": { "sequence": "MTEVGWWKLTFLRKKKSTPKVLYEIPDTYTQSEGGAEPPRPDSGNPNSNFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRASLAENPNLFDDREGKGQ", "length": 100, "header": "sp|Q3T183-1|PR15L_BOVIN Isoform 1 of Proline-rich protein 15-like protein OS=Bos taurus OX=9913 GN=PRR15L PE=3 SV=1 CANONICAL=Q3T183-1" }, "locus": { "chromosome": "19", "start_pos": 38515660, "end_pos": 38515361, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136018.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136018.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094869.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616622", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616622", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I2F5-1", "protein_name": "Proline-rich protein 15-like protein", "gene_name": "Prr15l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTEVGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGGTEPPGPDAGDPHSDFNTRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRAMLAENPSLFDDREDKGQ", "length": 100 }, "evidence": [ { "id": "Q3T183", "url": "https://omabrowser.org/oma/group/Q3T183/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8JZM2-1", "protein_name": "Proline-rich protein 15-like protein", "gene_name": "Prr15l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTEVGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGGAEPPGPDAGDPHSDFNSRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRAMLAENPNLFDDRENKGQ", "length": 100 }, "evidence": [ { "id": "Q3T183", "url": "https://omabrowser.org/oma/group/Q3T183/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T183-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 100, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T183-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T183" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIP3-1", "uniprot_ac": "Q2KIP3", "uniprot_id": "GAR1B_BOVIN", "mass": { "chemical_mass": 38852.0, "monoisotopic_mass": 38852.0 }, "refseq": { "ac": "NP_001039922", "name": "Golgi-associated RAB2 interactor protein 1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" }, "gene_names": [ { "name": "GARIN1B", "type": "recommended", "evidence": [ { "id": "Q2KIP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ] }, { "name": "FAM137A", "type": "synonym", "evidence": [ { "id": "Q2KIP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ] }, { "name": "FAM71F1", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" }, { "id": "Q2KIP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ] }, { "name": "GARIN1B", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] }, { "name": "NYD-SP18", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] } ], "protein_names": [ { "name": "Golgi-associated RAB2 interactor protein 1B", "type": "recommended", "evidence": [ { "id": "Q2KIP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3/entry#names_and_taxonomy" } ] }, { "name": "Golgi associated RAB2 interactor protein 1B", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] }, { "name": "Golgi-associated RAB2 interactor protein 1B", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] }, { "name": "family with sequence similarity 71 member F1", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] }, { "name": "protein FAM71F1", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] }, { "name": "testes development-related NYD-SP18", "type": "synonym", "evidence": [ { "id": "NP_001039922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922" } ] } ], "function": [ { "annotation": "RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3#function" }, { "database": "UniProtKB", "id": "Q3UZD7", "url": "https://www.uniprot.org/uniprotkb/Q3UZD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GARIN1B", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3", "locus": { "chromosome": "4", "start_pos": 92711399, "end_pos": 92695804, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009867", "url": "https://www.ensembl.org/id/ENSBTAG00000009867" } ] } } ], "crossref": [ { "id": "Q2KIP3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009867", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009867", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539444", "url": "https://www.ncbi.nlm.nih.gov/gene/539444", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539444", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539444", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VCDHLQR", "url": "https://omabrowser.org/oma/group/VCDHLQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIP3", "url": "https://www.orthodb.org/?gene=Q2KIP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQF9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQF9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIP3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSVPHRKTWNKSKKTVKVTRSYPTFPSLNAWEEFRGLFPVDGEPNPGVGLGVEEGLLGQMVHSPEFNLFPESVVFESNFVQVRKGRDWIDIYKTYNTMALGVTSSVPCLPLPNILLMASVKWHHGQNQTWNKPSTAPKIILKRILPLKFVELQVSDHLQRVLRLRTVTEKIYYLKLHPDHPKTVFHFWIRLIQILQKGLSITTKDPRILVTHCLVPKNSCSPSGDSQLVQKKPQASQPSESLMQLMAKGESEALCQIFVDLHQHNLFSSRSSKKTENKKDSSGKKTSPSEDSIPCTRDLSWRDSFTYGEWERENPSGPQSLSLLSTLAASTGPQLAPLIGSSI", "length": 345, "header": "sp|Q2KIP3-1|GAR1B_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 1B OS=Bos taurus OX=9913 GN=GARIN1B PE=2 SV=1 CANONICAL=Q2KIP3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQF9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3/entry#A0A3Q1MQF9-1", "sequence": { "sequence": "MLSSVPHRKTWNKSKKTVKVTRSYPTFPSLNAWEEFRGLFPVDGEPNPGVGLGVEEGLLGQMVHSPEFNLFPESVVFESNFVQVRKGRDWIDIYKTYNTMALGVTSSVPCLPLPNILLMASVKWHHGQNQTWNKPSTAPKIILKRILPLKFVELQVSDHLQRVLRLRTVTEKIYYLKLHPDHPKTVFHFWIRLIQILQKGLSITTKDPRILVTHCLVPKNSCSPSGDSQLVQKKPQASQPSESLMQLMAKGESEALCQIFVDLHQHNLFSSRSSKKTENKKDSSGKKTSPSEDSIPCTRDLSWRDSFTYGEWERENPSGPQSLSLLSTLAASTGPQLAPLIGSSIHPRIHLTFIKYFLCASV", "length": 362, "header": "tr|A0A3Q1MQF9-1|A0A3Q1MQF9_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor 1B OS=Bos taurus OX=9913 GN=GARIN1B PE=3 SV=1 CANONICAL=Q2KIP3-1" }, "locus": { "chromosome": "4", "start_pos": 92710674, "end_pos": 92695853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070029.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070029.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073841.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073841.1" } ] } }, { "isoform_ac": "Q2KIP3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3/entry#Q2KIP3-1", "sequence": { "sequence": "MLSSVPHRKTWNKSKKTVKVTRSYPTFPSLNAWEEFRGLFPVDGEPNPGVGLGVEEGLLGQMVHSPEFNLFPESVVFESNFVQVRKGRDWIDIYKTYNTMALGVTSSVPCLPLPNILLMASVKWHHGQNQTWNKPSTAPKIILKRILPLKFVELQVSDHLQRVLRLRTVTEKIYYLKLHPDHPKTVFHFWIRLIQILQKGLSITTKDPRILVTHCLVPKNSCSPSGDSQLVQKKPQASQPSESLMQLMAKGESEALCQIFVDLHQHNLFSSRSSKKTENKKDSSGKKTSPSEDSIPCTRDLSWRDSFTYGEWERENPSGPQSLSLLSTLAASTGPQLAPLIGSSI", "length": 345, "header": "sp|Q2KIP3-1|GAR1B_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 1B OS=Bos taurus OX=9913 GN=GARIN1B PE=2 SV=1 CANONICAL=Q2KIP3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539444", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539444", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F4H5-1", "protein_name": "Protein FAM71F1 isoform X5", "gene_name": "Fam71f1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMTSVPPRKPWWNSKKTVKVIRSYPTFPSLNAWEKFRGLLPVDGEPNPGVGLGVEEGLLCQIVHSPEFNLFPNSVVFESNFVQVRRSRHWKEIYKASNTMALGVTSSVPCLPLPNILLMARVKWHQGQSQTWNRPSTAPSIILKSILPLKFVELQICDHHERILRLRTVTEKIYFLKLHPDHPETVFLFWIRLVQILQKGLSITTKDPSILVTHCLVPKSLCNPCGKSELVQKKPPCSRPSESLMQLMAQGESEALSQIFADLHQQKQYSSRRSKEMQINKTSSEKATPSEDSIPCTRDLSWRDAFTYGEWERENPSGPQPLSLLGTLAASSRPRLSLTGGTVMMGLIWWSSRDRLEFKLRIGTVSWGPQGNSRGPHPLPFCLLVFASYAIE", "length": 392 }, "evidence": [ { "id": "Q2KIP3", "url": "https://omabrowser.org/oma/group/Q2KIP3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q68FV5-1", "protein_name": "Golgi-associated RAB2 interactor protein 1B", "gene_name": "Garin1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMTSVPPRKTWWKSKKTVKVRRSYSTFPSLNAWEKFRGLLPVDGETNPGVGLGVEEGLLCQMVHSPEFNLFPNSVVFESNFVQVRRSRDWKEIYKASNTMALGVTSSVPCLPLPNILLMARVIWHQGQSQTWNRPSTVPSINLKSILPLKFVELQIWDHHERILRLRTVTEKIYFLKLHPDHPETVFRFWIRLVQILHKGLSITTKDPTILVTHCLVPKSLCSPGGKSELVQKNSKGLQPSESLTHLMAQGESEALSQIFSDLHQQKQYSSSRSEKVQINKTSSEKATPCEDSIPCTCDLNWRDAFMFGEWERENPSGPQPHSLLSTLAASSRPRLSLIGGNSI", "length": 344 }, "evidence": [ { "id": "Q2KIP3", "url": "https://omabrowser.org/oma/group/Q2KIP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96KD3-1", "protein_name": "Golgi-associated RAB2 interactor protein 1B", "gene_name": "GARIN1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSSFPHRKTWRKSKKTVKVTRSYPTFPSLNAWEEFRGLLPVDGEPNPGAGLGVEEGLLCRVVHSPEFNLFLDSVVFESNFIQVKRGRNWRDVYKASNTMALGVTSSVPCLPLPNILLMASVKWHQGQNQTWNRPSIAPNIFLKRILPLRFVELQVCDHYQRILQLRTVTEKIYYLKLHPDHPETVFHFWIRLVQILQKGLSITTKDPRILVTHCLVPKNCSSPSGDSKLVQKKLQASQPSESLIQLMTKGESEALSQIFADLHQQNQLSFRSSRKVETNKNSSGKDSSREDSIPCTCDLRWRASFTYGEWERENPSGLQPLSLLSTLAASTGPQLAPPIGNSI", "length": 344 }, "evidence": [ { "id": "Q2KIP3", "url": "https://omabrowser.org/oma/group/Q2KIP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "acrosome reaction", "id": "GO:0007340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP3", "url": "https://www.uniprot.org/uniprotkb/Q2KIP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIP3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIP3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIP3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 12, "end_pos": 14 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBP0-1", "uniprot_ac": "Q3ZBP0", "uniprot_id": "IFTAP_BOVIN", "mass": { "chemical_mass": 27213.0, "monoisotopic_mass": 27213.0 }, "refseq": { "ac": "NP_001029922", "name": "intraflagellar transport-associated protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" }, "gene_names": [ { "name": "IFTAP", "type": "recommended", "evidence": [ { "id": "Q3ZBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ] }, { "name": "C11orf74", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] }, { "name": "C15H11orf74", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] }, { "name": "IFTAP", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] } ], "protein_names": [ { "name": "Intraflagellar transport-associated protein", "type": "recommended", "evidence": [ { "id": "Q3ZBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#names_and_taxonomy" } ] }, { "name": "Protein HEPIS", "type": "synonym", "evidence": [ { "id": "Q3ZBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#names_and_taxonomy" } ] }, { "name": "chromosome 15 C11orf74 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] }, { "name": "intraflagellar transport-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] }, { "name": "uncharacterized protein C11orf74 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922" } ] } ], "function": [ { "annotation": "Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0#function" }, { "database": "UniProtKB", "id": "Q86VG3", "url": "https://www.uniprot.org/uniprotkb/Q86VG3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFTAP", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0", "locus": { "chromosome": "15", "start_pos": 67089356, "end_pos": 67022660, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021611", "url": "https://www.ensembl.org/id/ENSBTAG00000021611" } ] } } ], "crossref": [ { "id": "Q3ZBP0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021611", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021611", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614192", "url": "https://www.ncbi.nlm.nih.gov/gene/614192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614192", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614192", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KFINCHE", "url": "https://omabrowser.org/oma/group/KFINCHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBP0", "url": "https://www.orthodb.org/?gene=Q3ZBP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35543", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35543", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35543:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35543:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17722", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17722", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQN7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0B4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0B4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0B4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P133", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P133", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P133-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P133-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY3", "url": "https://www.uniprot.org/uniprotkb/F1MNY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MNY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQIMIGDGQKAGSSFQGDLNRAGKVKVDNFLDIEDLDLDEEINPQLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEIVGDEVQPFSLDEEFDYDAVVLTPKFTPAEMNAIKELSKQKTKSADLEDPHD", "length": 242, "header": "sp|Q3ZBP0-1|IFTAP_BOVIN Isoform 1 of Intraflagellar transport-associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=2 SV=1 CANONICAL=Q3ZBP0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQN7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#A0A3Q1MQN7-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQMCCCFQDKWSRK", "length": 108, "header": "tr|A0A3Q1MQN7-1|A0A3Q1MQN7_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=2 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67080216, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069562.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069562.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056704.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056704.2" } ] } }, { "isoform_ac": "A0AAA9TCL2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#A0AAA9TCL2-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQIMIGDGQKAGSSFQGDLNRAGKVKFLLSLWFKAHRYENRQTHHHRWPEKHKQ", "length": 148, "header": "tr|A0AAA9TCL2-1|A0AAA9TCL2_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=2 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67067843, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105981.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105981.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094598.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094598.2" } ] } }, { "isoform_ac": "A0AAF7A0B4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#A0AAF7A0B4-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQVDNFLDIEDLDLDEEINPQLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEIVGDEVQPFSLDEEFDYDAVVLTPKFTPAEMNAIKELSKQKTKSADLEDPHD", "length": 218, "header": "tr|A0AAF7A0B4-1|A0AAF7A0B4_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=1 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67089266, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079860.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079860.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060968.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060968.2" } ] } }, { "isoform_ac": "A0AAF7AEP7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#A0AAF7AEP7-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQVDNFLDIEDLDLDEEINPQLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEVLLREFRSNCLNSITGPFREMPPYPCVPVFFS", "length": 198, "header": "tr|A0AAF7AEP7-1|A0AAF7AEP7_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=1 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67080424, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079262.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079262.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067726.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067726.2" } ] } }, { "isoform_ac": "A0ABI0P133-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#A0ABI0P133-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEIVGDEVQPFSLDEEFDYDAVVLTPKFTPAEMNAIKELSKQKTKSADLEDPHD", "length": 144, "header": "tr|A0ABI0P133-1|A0ABI0P133_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=1 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67089266, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106617.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106617.1" } ] } }, { "isoform_ac": "F1MNY3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#F1MNY3-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQVDNFLDIEDLDLDEEINPQLSKDRWRRSSALLA", "length": 129, "header": "tr|F1MNY3-1|F1MNY3_BOVIN Computationally mapped isoform of Intraflagellar transport associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=4 SV=4 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67089142, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054498.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054498.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049870.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049870.4" } ] } }, { "isoform_ac": "Q3ZBP0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0/entry#Q3ZBP0-1", "sequence": { "sequence": "MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQIMIGDGQKAGSSFQGDLNRAGKVKVDNFLDIEDLDLDEEINPQLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEIVGDEVQPFSLDEEFDYDAVVLTPKFTPAEMNAIKELSKQKTKSADLEDPHD", "length": 242, "header": "sp|Q3ZBP0-1|IFTAP_BOVIN Isoform 1 of Intraflagellar transport-associated protein OS=Bos taurus OX=9913 GN=IFTAP PE=2 SV=1 CANONICAL=Q3ZBP0-1" }, "locus": { "chromosome": "15", "start_pos": 67089266, "end_pos": 67040841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028797.4", "url": "https://www.ensembl.org/id/ENSBTAT00000028797.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028797.2", "url": "https://www.ensembl.org/id/ENSBTAP00000028797.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 172, "start_aa": "Thr", "end_pos": 172, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr172", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "site_lbl": "Ser57" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614192", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614192", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MQQ5-1", "protein_name": "Intraflagellar transport-associated protein", "gene_name": "Iftap", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPAQILRPEIMDEDQLMKEVLDKFINCHEQTYEEFLSTFTHLSKEDIVAKGGSHGSDSSENIFTAEKLIRKNESNGHHFRNTAIFPHTSSECSEEDQIVIDEGQQVGSFLQGDMTRAGKVKVDNFLDLEDLDMEEDSKPQMNKDWMLLPGEVEQGIITSVPAYVPSVDLPLSSEVKPKPAEGRTLKPTEEIFGDEVQPFFLDEEFDYDNVTLTPKFTAGEIATIQELAKQKRMDTNRDFFEAHN", "length": 244 }, "evidence": [ { "id": "Q3ZBP0", "url": "https://omabrowser.org/oma/group/Q3ZBP0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1A6Q0-1", "protein_name": "C11orf74 homolog", "gene_name": "C11orf74", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGEQLVNNCILDQFINSHEQSYEEFLSTFTYLLKEDERKTIQGRKKSLRKSFSASEISNGNKQDGLPERSKEKLVSFPPQTPNENKTVINESWKSGGSDGNGLSLSERAQVDHHLETDIDGEPRNAGSFVLPGEVEEIGTSCTPPLEKPVQRKLKTSSVQQPLDNKAEELLGDDVQPFLLDEEFDYDNVALTPKFSEAELMPMKELSEEKKRGQM", "length": 215 }, "evidence": [ { "id": "Q3ZBP0", "url": "https://omabrowser.org/oma/group/Q3ZBP0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LAT9-1", "protein_name": "Intraflagellar transport associated protein", "gene_name": "Iftap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAQIPRRPEIMSEDQLMKEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVAKGGAHGMNLSENTLTAEKWNHKIESNGHHFRNRTIFLHDSSECSEEDQIVIDEGQKVGSSFQGDMTRAGKVKVDNFLDLEDVDTEEESKPQMNKDWMALPGEVEQGISISAPAYVPAVGLPLTSEGKPTPAVGRTQTQTEEILGDEVQPFFLDEDFDYDNVTLTPKFTAGEIATIQELAKQKRVDTSTHVCELHD", "length": 245 }, "evidence": [ { "id": "Q3ZBP0", "url": "https://omabrowser.org/oma/group/Q3ZBP0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86VG3-1", "protein_name": "Intraflagellar transport-associated protein", "gene_name": "IFTAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAHMSGLEIMDEDQLIKDVLDKFLNCHEQTYDEEFLNTFTHLSQEDHVSKRGVFGTDSSENIFTSAKVTHKNEADDYHLRNKTIFLRTSSQCLEEQVDNFLDLEDLDMDEEIKPQMSEDLLLLPGEVEQDVSTSIPSCIPFVAQPPTCEVKPKPSVKRMDKQTEEILGDEVQLFSLDEEFDYDNVMLTSKFSPAEIENIKELCKQQKRKDTSPDLEKSCD", "length": 221 }, "evidence": [ { "id": "Q3ZBP0", "url": "https://omabrowser.org/oma/group/Q3ZBP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQI4-1", "protein_name": "Intraflagellar transport-associated protein", "gene_name": "Iftap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLAQIPRPEIMDEDQLMKEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVAKWGAHGTDSSENIFSTVKWNHKTESNGRHFRNTSIFLHTSSEHSEEDQIVIDEGHKVGSSFQGDMTRAGKVKVDNFLDLEDVDMEEESKPQMNKDCLLLPGEVEQDISTSVPSYDPSVDLPLTSEVRPKPAVGRTQKQTEEILGDEVQPFFLDEEFDYDNVTLTPKFTAGEIATIQELSKQKRVGSGTNVCELHD", "length": 244 }, "evidence": [ { "id": "Q3ZBP0", "url": "https://omabrowser.org/oma/group/Q3ZBP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "pmid": "" }, { "name": "9+0 non-motile cilium", "id": "GO:0097731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097731", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "pmid": "" }, { "name": "acrosome reaction", "id": "GO:0007340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "intraciliary transport particle A binding", "id": "GO:0120160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120160", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 242, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBP0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 172 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 57 ], "sequon_annotation_sites": [ { "start_pos": 46, "end_pos": 48 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E936-1", "uniprot_ac": "Q5E936", "uniprot_id": "TXD12_BOVIN", "mass": { "chemical_mass": 19222.0, "monoisotopic_mass": 19222.0 }, "refseq": { "ac": "NP_001015536", "name": "thioredoxin domain-containing protein 12 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" }, "gene_names": [ { "name": "TXNDC12", "type": "recommended", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] }, { "name": "ERP18", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] }, { "name": "TLP19", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] }, { "name": "TXNDC12", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] } ], "protein_names": [ { "name": "Thioredoxin domain-containing protein 12", "type": "recommended", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936/entry#names_and_taxonomy" } ] }, { "name": "1.8.4.2", "type": "synonym", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936/entry#names_and_taxonomy" } ] }, { "name": "endoplasmic reticulum thioredoxin superfamily member, 18 kDa", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] }, { "name": "thioredoxin domain-containing protein 12 precursor", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] }, { "name": "thioredoxin domain-containing protein 12", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] }, { "name": "thioredoxin-like protein p19", "type": "synonym", "evidence": [ { "id": "NP_001015536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536" } ] } ], "function": [ { "annotation": "Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936#function" }, { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprotkb/O95881#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TXNDC12", "url": "https://www.uniprot.org/uniprotkb/Q5E936", "locus": { "chromosome": "3", "start_pos": 94312519, "end_pos": 94278860, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011024", "url": "https://www.ensembl.org/id/ENSBTAG00000011024" } ] } } ], "crossref": [ { "id": "Q5E936", "url": "https://alphafold.ebi.ac.uk/entry/Q5E936", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011024", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011024", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506991", "url": "https://www.ncbi.nlm.nih.gov/gene/506991", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506991", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506991", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SEHFVMV", "url": "https://omabrowser.org/oma/group/SEHFVMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWL9", "url": "https://www.orthodb.org/?gene=A0A3Q1MWL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E936", "url": "https://www.orthodb.org/?gene=Q5E936", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15337", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15337", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15337:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15337:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13899", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13899", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015536", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21064", "url": "https://www.rhea-db.org/rhea/21064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MWL9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWL9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E936-1", "url": "https://www.uniprot.org/uniprotkb/Q5E936-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELRPRLGATCLLGFSFLLLVTSSHGPNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVRPEIINENGNPSYKYFYISAEQVVQGMKEAQERLTGDAFREKHLEDEL", "length": 172, "header": "sp|Q5E936-1|TXD12_BOVIN Isoform 1 of Thioredoxin domain-containing protein 12 OS=Bos taurus OX=9913 GN=TXNDC12 PE=2 SV=1 CANONICAL=Q5E936-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MWL9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E936/entry#A0A3Q1MWL9-1", "sequence": { "sequence": "MELRPRLGATCLLGFSFLLLVTSSHGPNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEVRIPELLSAVILSLHYPSGKVRPEIINENGNPSYKYFYISAEQVVQGMKEAQERLTGDAFREKHLEDEL", "length": 164, "header": "tr|A0A3Q1MWL9-1|A0A3Q1MWL9_BOVIN Computationally mapped isoform of protein-disulfide reductase (glutathione) OS=Bos taurus OX=9913 GN=TXNDC12 PE=1 SV=1 CANONICAL=Q5E936-1" }, "locus": { "chromosome": "3", "start_pos": 94311749, "end_pos": 94278991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087181.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087181.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059910.1" } ] } }, { "isoform_ac": "A0AAA9TYY9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E936/entry#A0AAA9TYY9-1", "sequence": { "sequence": "MELRPRLGATCLLGFSFLLLVTSSHGPNGLGKGFGDHIHWRTLEDGKKEAAARPPL", "length": 56, "header": "tr|A0AAA9TYY9-1|A0AAA9TYY9_BOVIN Computationally mapped isoform of Thioredoxin domain containing 12 OS=Bos taurus OX=9913 GN=TXNDC12 PE=4 SV=1 CANONICAL=Q5E936-1" }, "locus": { "chromosome": "3", "start_pos": 94300906, "end_pos": 94278991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102733.1" } ] } }, { "isoform_ac": "Q5E936-1", "url": "https://www.uniprot.org/uniprotkb/Q5E936/entry#Q5E936-1", "sequence": { "sequence": "MELRPRLGATCLLGFSFLLLVTSSHGPNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVRPEIINENGNPSYKYFYISAEQVVQGMKEAQERLTGDAFREKHLEDEL", "length": 172, "header": "sp|Q5E936-1|TXD12_BOVIN Isoform 1 of Thioredoxin domain-containing protein 12 OS=Bos taurus OX=9913 GN=TXNDC12 PE=2 SV=1 CANONICAL=Q5E936-1" }, "locus": { "chromosome": "3", "start_pos": 94311749, "end_pos": 94278991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014645.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014645.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014645.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014645.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506991", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506991", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A481A893-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "TXNDC12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPRPRLGATCLLGFSFLLLVSSDGHVGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELAHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVRPEIINEHGNPSYKYFYVNAEQVVQGMKEAQERLTGDAFREKHLEDEL", "length": 171 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QLA1-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "Txndc12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLRFGATCLLCFSFLLLITSSAGHIGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESKEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYINAEQVVQGMKEAQERLTGDAFRGKHFQDEL", "length": 170 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1A059-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "TXNDC12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAQPAAASVLCLCLCLLMAASAAAAAEGLGKGFGDHIHWRTLEDGKKEAAASGLPLMIIIHKSWCGACKALKPKFAESKEISELAHNFVMVNLEDDEEPKDEAFSPDGGYIPRILFMDPSGKVHPEIINEKGNPSYKYFYTNADQVIQGMKEAQEKLTGDAFKQKHLGDEL", "length": 172 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O95881-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "TXNDC12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL", "length": 172 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q498E0-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "Txndc12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDEDFSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQVRLTGDAFREKHFQDEL", "length": 170 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQU0-1", "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "Txndc12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDEDFSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFREKHFQDEL", "length": 170 }, "evidence": [ { "id": "Q5E936", "url": "https://omabrowser.org/oma/group/Q5E936/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-disulfide reductase (glutathione) activity", "id": "GO:0019153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019153", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q5E936", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21064", "name": "", "equation": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E936-1", "A0AAA9SI25-1", "F1N151-1" ], "evidence": [ { "id": "21064", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21064" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SI25", "gene_name": "", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] } ] }, { "uniprot_ac": "F1N151", "gene_name": "DNAJC10", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] } ] }, { "uniprot_ac": "Q5E936", "gene_name": "TXNDC12", "activity": [ { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E936-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 172, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E936-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E936" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" }, { "id": "PRU10138", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10138" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Prevents secretion from ER", "eco_id": "ECO_0000255", "start_pos": 169, "end_pos": 172, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.8.4.2", "ec_name": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "1.8.4.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2" }, { "id": "1.8.4.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.4.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CT4-1", "uniprot_ac": "Q58CT4", "uniprot_id": "S68A1_BOVIN", "mass": { "chemical_mass": 57198.0, "monoisotopic_mass": 57198.0 }, "refseq": { "ac": "NP_001014925", "name": "solute carrier family 68 member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" }, "gene_names": [ { "name": "MFSD13A", "type": "recommended", "evidence": [ { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ] }, { "name": "SLC68A1", "type": "recommended", "evidence": [ { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ] }, { "name": "C10orf77", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" } ] }, { "name": "MFSD13A", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" }, { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ] }, { "name": "SLC68A1", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" } ] }, { "name": "TMEM180", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" }, { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ] } ], "protein_names": [ { "name": "Solute carrier family 68 member 1", "type": "recommended", "evidence": [ { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4/entry#names_and_taxonomy" } ] }, { "name": "Major facilitator superfamily domain-containing 13A", "type": "synonym", "evidence": [ { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 180", "type": "synonym", "evidence": [ { "id": "Q58CT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CT4/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 68 member 1", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" } ] }, { "name": "transmembrane protein 180", "type": "synonym", "evidence": [ { "id": "NP_001014925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925" } ] } ], "function": [ { "annotation": "May act as a cation symporter.", "evidence": [ { "database": "UniProtKB", "id": "Q58CT4", "url": "https://www.uniprot.org/uniprotkb/Q58CT4#function" }, { "database": "UniProtKB", "id": "Q14CX5", "url": "https://www.uniprot.org/uniprotkb/Q14CX5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CT4", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC68A1", "url": "https://www.uniprot.org/uniprotkb/Q58CT4", "locus": {} } ], "crossref": [ { "id": "Q58CT4", "url": "https://alphafold.ebi.ac.uk/entry/Q58CT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17481", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17481", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514370", "url": "https://www.ncbi.nlm.nih.gov/gene/514370", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514370", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514370", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WNSVNDP", "url": "https://omabrowser.org/oma/group/WNSVNDP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NG83", "url": "https://www.orthodb.org/?gene=A0A3Q1NG83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CT4", "url": "https://www.orthodb.org/?gene=Q58CT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28658:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28658:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NG83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NG83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CT4", "url": "https://www.uniprot.org/uniprotkb/Q58CT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CT4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLGGPWAWLLGLPTAVVYGSLALFVSVLHNVFLLYYVDTFVSVYKIDKAAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCLALATGSGLGFVGAARLLRRRVEAAGREPGCPAMAVNDGLCEEELLVGGEEAGSITLGQYLQQLARHRNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHPGLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQHPPAPVGSAQPWPEPPAPPPAQAPPLRQGCFYLLVLVPIACALLQLFTWSQFTLHGRRLHMVKAQRQSLSRAQTLDVKMV", "length": 517, "header": "sp|Q58CT4-1|S68A1_BOVIN Isoform 1 of Solute carrier family 68 member 1 OS=Bos taurus OX=9913 GN=SLC68A1 PE=2 SV=1 CANONICAL=Q58CT4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NG83-1", "url": "https://www.uniprot.org/uniprotkb/Q58CT4/entry#A0A3Q1NG83-1", "sequence": { "sequence": "MPGCLKCGHGPAASVPPGSLLEMQNLRFHSTPVKGQVWPECPWPWAHLSAPGAEAGLAAMRLGGPWAWLLGLPTAVVYGSLALFVSVLHNVFLLYYVDTFVSVYKIDKAAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCLALATGSGLGFVGAARLLRRRVEAAGREPGCPAMAVNDGLCEEELLVGGEEAGSITLGQYLQQLARHRNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHPGLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQHPPAPVGSAQPWPEPPAPPPAQAPPLRQGCFYLLVLVPIACALLQLFTWSQFTLHGRRLHMVKAQRQSLSRAQTLDVKMV", "length": 576, "header": "tr|A0A3Q1NG83-1|A0A3Q1NG83_BOVIN Computationally mapped isoform of Major facilitator superfamily domain containing 13A OS=Bos taurus OX=9913 GN=MFSD13A PE=4 SV=2 CANONICAL=Q58CT4-1" }, "locus": { "chromosome": "26", "start_pos": 23086840, "end_pos": 23080149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073612.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073612.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070800.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070800.2" } ] } }, { "isoform_ac": "Q58CT4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CT4/entry#Q58CT4-1", "sequence": { "sequence": "MRLGGPWAWLLGLPTAVVYGSLALFVSVLHNVFLLYYVDTFVSVYKIDKAAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCLALATGSGLGFVGAARLLRRRVEAAGREPGCPAMAVNDGLCEEELLVGGEEAGSITLGQYLQQLARHRNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHPGLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQHPPAPVGSAQPWPEPPAPPPAQAPPLRQGCFYLLVLVPIACALLQLFTWSQFTLHGRRLHMVKAQRQSLSRAQTLDVKMV", "length": 517, "header": "sp|Q58CT4-1|S68A1_BOVIN Isoform 1 of Solute carrier family 68 member 1 OS=Bos taurus OX=9913 GN=SLC68A1 PE=2 SV=1 CANONICAL=Q58CT4-1" }, "locus": { "chromosome": "26", "start_pos": 23086840, "end_pos": 23081469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028052.4", "url": "https://www.ensembl.org/id/ENSBTAT00000028052.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028052.2", "url": "https://www.ensembl.org/id/ENSBTAP00000028052.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CT4", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514370", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514370", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U3N0-1", "protein_name": "Major facilitator superfamily domain containing 13A", "gene_name": "MFSD13A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELNADPINMGLRLLACLFHLPTAVIYGSLSLFVSILHNVFLLYYVDTFVSVYKIDKLSFWIGETVFLIWNSLNDPLFGWLSDRVFLSTQQPGAEISSPEVVLKRLRALSHNGPLFAISFLAFWVAWAHPGLQFLLCLCMYDSFLTMVDLHHNALLADLAVSAKDRTSLNFYCSFFSAIGSLSVFMSYAVWNKEDFFSFRIFCIVLAFCSIVGFTLSTQLLRQRFETDGKAKWDQESTLKELYIEKLSVPQEKRITLVEYLQQLSRHRNFLWFVCMNLIQVFHCHFNSNFFPLFLEHLLSDKISVSTGSFLLGISYIAPHLNNLYFLSLCRRWGVYAVVRGLFFLKLALSVVMLLAGPDQVYLLCIFIASNRVFTEGTCKLLNLVVTDLVDEDLVLNRRKQAASALLFGMVALVTKPGQTFAPLIGTWLLCVYTGYDIFQRNPLSNVVSAQPKLESDTILEPTLRQGCFYLLVFVPITCALLQLLSWTQFSLHGKRLQMVKAQRQGLMQGRAPEIKMI", "length": 518 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TUM7-1", "protein_name": "Major facilitator superfamily domain containing 13A", "gene_name": "MFSD13A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELGGPWAWLLGLPTAVVYGSLALFVSVLHNVFLLYYVDTFVSVYKINKAAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPWSGAGLSSRAVVLARVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCVALAACSGLGFVGATRLLRRRVEAAGREPGCPSLAVDGGLGEEELLVGGKEAGSITLSQYLRQLARHRNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHPGLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQPPLTPVGSAQPWPEPPAPPPAQAPALRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRLHMVKAQRQNLARAQTLDVKTV", "length": 517 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0KYP0-1", "protein_name": "Major facilitator superfamily domain containing 13A", "gene_name": "Slc68a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARTSRRRGTTSLGLRHPAAGRPTRVAWRRRGPGPYHGSSGVLAAPCSGPPAGCRSCGSGWVAAAEGRAGSSSAALGGLAASSFLQMGVSLFSSFSPCLPMKSRDEDGRSGNGAEAPPAAMGLDWPPAWLLGLPTAVVYGSLAFFTTILHNVFLLYYVDTFVSVYKINKVSFWVGETVFLLWNSFNDPLFGWLSDRRFLSSQPRSGAGLSSRDVVLTRVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGAMSVFASYAFWNKEDFSSFRAFCVVLAAGSGLGFLGATQLLKRRIEATRKDRGCPGLVMDGGVCEEEPLVGGEEAGSITLGQYLRQLAHHQNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLLLLKLSLSLLMLLAGPDHPGLLCFFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQPPVTSVGSVQPWPEPPAPAPVQAPTLRQGCFYLLVLVPIICALLQLFTWSQFTLHGRRLRMVKAQRQNLAQIHTLNIKMV", "length": 637 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HXW7-1", "protein_name": "Transmembrane protein 180", "gene_name": "Mfsd13a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGLDWPQAWLLGLPTAVVYGSLALFTSILHNVFLLYYVDTFVSVYKINKMSFWIGETVFLLWNSFNDPLFGWLSDRQFLSSQSRSGAGLSSRDVVLTRVRALSWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSMSVFASYAFWNKEDFSSFRAFCVVLAAGSGLGFLGATQLLRRRIEATRRDKGCPALVVDGGVCEEELLVGGEEAGSITLGQYLRQLARHQNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDRPGLLCFFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQPPVTTVGSVQPWPEPPAPAPAQAPTLRQGCFYLLVLVSISCALLQLFTWSRFTLHGRRLRVVKAQRQNLAQIHTLDIKTV", "length": 517 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q14CX5-1", "protein_name": "Solute carrier family 68 member 1", "gene_name": "SLC68A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLGQPQAWLLGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSGLVVDSGLCGEELLVGSEEADSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQSLITPVGSAHPWPEPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRLHMVKAQRQNLSQAQTLDVKMV", "length": 517 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PDE8-1", "protein_name": "Solute carrier family 68 member 1", "gene_name": "Slc68a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLDWPQAWLLGLPIAVVYGSLALFTSILHNVFLLYYVDTFVSVYKINKVSFWVGETVFLLWNSFNDPLFGWLSDRQLLSSQPRSGAGLSSRDVVLTRVRALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSSHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCVVLAAGSGLGFLGTTQLLKRQIEATRRDRGCPGLDLDGGVCEEEPPVGGEEAGNITLGQYLRQLARHQNFLWFVGMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSFLLGISYVAPHLNNLYFLPLCRRWGVYAVVRGLFLLKLSLSLLMLLAGPDHPGLLCFFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQSPMTPVGSVRPWPELPAPAPAPAQAPTLRQGCFYLLVFVPITCALLQLFTWSQFTLHGRRLRTVKAQRQNLAQIHTLNIKMV", "length": 519 }, "evidence": [ { "id": "Q58CT4", "url": "https://omabrowser.org/oma/group/Q58CT4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58CT4", "url": "https://www.uniprot.org/uniprotkb/Q58CT4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CT4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 517, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CT4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CT4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIX2-1", "uniprot_ac": "Q2KIX2", "uniprot_id": "GDAP2_BOVIN", "mass": { "chemical_mass": 56263.0, "monoisotopic_mass": 56263.0 }, "refseq": { "ac": "NP_001039478", "name": "ganglioside-induced differentiation-associated protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039478" }, "gene_names": [ { "name": "GDAP2", "type": "recommended", "evidence": [ { "id": "Q2KIX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2" } ] }, { "name": "GDAP2", "type": "synonym", "evidence": [ { "id": "NP_001039478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039478" } ] } ], "protein_names": [ { "name": "Ganglioside-induced differentiation-associated protein 2", "type": "recommended", "evidence": [ { "id": "Q2KIX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2/entry#names_and_taxonomy" } ] }, { "name": "ganglioside-induced differentiation-associated protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039478" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIX2", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GDAP2", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2", "locus": { "chromosome": "3", "start_pos": 25354109, "end_pos": 25289416, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016387", "url": "https://www.ensembl.org/id/ENSBTAG00000016387" } ] } } ], "crossref": [ { "id": "Q2KIX2", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016387", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016387", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02905", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02905", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508774", "url": "https://www.ncbi.nlm.nih.gov/gene/508774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508774", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIS7", "url": "https://www.orthodb.org/?gene=A0A452DIS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIX2", "url": "https://www.orthodb.org/?gene=Q2KIX2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11106:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11106:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039478", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIS7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX2", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPLGAPSQFVDVDTLPSWGNSCEDQLNASEIAAETYQEETIRSPFLYNKDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLRGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETLEKVVFAVSELEEATYQKLLPLYFPRSLKEESRSLPCLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRRLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSYLPSPDL", "length": 497, "header": "sp|Q2KIX2-1|GDAP2_BOVIN Isoform 1 of Ganglioside-induced differentiation-associated protein 2 OS=Bos taurus OX=9913 GN=GDAP2 PE=2 SV=1 CANONICAL=Q2KIX2-1" }, "isoforms": [ { "isoform_ac": "A0A452DIS7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2/entry#A0A452DIS7-1", "sequence": { "sequence": "MDPLGAPSQFVDVDTLPSWGNSCEDQLNASEIAAETYQEETIRSPFLYNKDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLRGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETLEKVVFAVSELEEATYQKLLPLYFPRSLKEESRSLPCLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRRLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARVVCSVMSDCFNLMDCRPSGFSVHRIFQARILEWVLPDTGIEPTSPALAGRYFTTEPLGEPFLYS", "length": 546, "header": "tr|A0A452DIS7-1|A0A452DIS7_BOVIN Computationally mapped isoform of Ganglioside induced differentiation associated protein 2 OS=Bos taurus OX=9913 GN=GDAP2 PE=3 SV=2 CANONICAL=Q2KIX2-1" }, "locus": { "chromosome": "3", "start_pos": 25350088, "end_pos": 25299568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021791.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021791.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021791.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021791.7" } ] } }, { "isoform_ac": "A0AAA9SL62-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2/entry#A0AAA9SL62-1", "sequence": { "sequence": "MDPLGAPSQFVDVDTLPSWGNSCEDQLNASEIAAETYQEETIRSPFLYNKDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLRGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETLEKVVFAVSELEEATYQKLLPLYFPRSLKEESRSLPCLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRRLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKMKRLGPDWSTFVFIVEWKNIRPSLHSKVVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSYLPSPDL", "length": 525, "header": "tr|A0AAA9SL62-1|A0AAA9SL62_BOVIN Computationally mapped isoform of Ganglioside induced differentiation associated protein 2 OS=Bos taurus OX=9913 GN=GDAP2 PE=3 SV=1 CANONICAL=Q2KIX2-1" }, "locus": { "chromosome": "3", "start_pos": 25353592, "end_pos": 25299568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110749.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110749.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086011.1" } ] } }, { "isoform_ac": "Q2KIX2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2/entry#Q2KIX2-1", "sequence": { "sequence": "MDPLGAPSQFVDVDTLPSWGNSCEDQLNASEIAAETYQEETIRSPFLYNKDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLRGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETLEKVVFAVSELEEATYQKLLPLYFPRSLKEESRSLPCLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRRLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSYLPSPDL", "length": 497, "header": "sp|Q2KIX2-1|GDAP2_BOVIN Isoform 1 of Ganglioside-induced differentiation-associated protein 2 OS=Bos taurus OX=9913 GN=GDAP2 PE=2 SV=1 CANONICAL=Q2KIX2-1" }, "locus": { "chromosome": "3", "start_pos": 25353592, "end_pos": 25299568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112504.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112504.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076558.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX2", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2" } ], "site_lbl": "Ser280" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508774", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508774", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIX2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 497, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIX2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIX2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX2" }, { "id": "PRU00490", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00490" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Macro", "eco_id": "ECO_0000255", "start_pos": 43, "end_pos": 223, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 280 ], "sequon_annotation_sites": [ { "start_pos": 28, "end_pos": 30 }, { "start_pos": 67, "end_pos": 69 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T110-1", "uniprot_ac": "Q3T110", "uniprot_id": "T4S18_BOVIN", "mass": { "chemical_mass": 22199.0, "monoisotopic_mass": 22199.0 }, "refseq": { "ac": "NP_001029459", "name": "transmembrane 4 L6 family member 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029459" }, "gene_names": [ { "name": "TM4SF18", "type": "recommended", "evidence": [ { "id": "Q3T110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T110" } ] }, { "name": "TM4SF18", "type": "synonym", "evidence": [ { "id": "NP_001029459", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029459" } ] } ], "protein_names": [ { "name": "Transmembrane 4 L6 family member 18", "type": "recommended", "evidence": [ { "id": "Q3T110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T110/entry#names_and_taxonomy" } ] }, { "name": "transmembrane 4 L6 family member 18", "type": "synonym", "evidence": [ { "id": "NP_001029459", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029459" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T110", "url": "https://www.uniprot.org/uniprotkb/Q3T110" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM4SF18", "url": "https://www.uniprot.org/uniprotkb/Q3T110", "locus": { "chromosome": "1", "start_pos": 118883977, "end_pos": 118859228, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019960", "url": "https://www.ensembl.org/id/ENSBTAG00000019960" } ] } } ], "crossref": [ { "id": "Q3T110", "url": "https://alphafold.ebi.ac.uk/entry/Q3T110", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019960", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019960", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507280", "url": "https://www.ncbi.nlm.nih.gov/gene/507280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507280", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507280", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIX6", "url": "https://www.orthodb.org/?gene=A0A452DIX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T110", "url": "https://www.orthodb.org/?gene=Q3T110", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029459", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIX6", "url": "https://www.uniprot.org/uniprotkb/A0A452DIX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T110", "url": "https://www.uniprot.org/uniprotkb/Q3T110", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T110-1", "url": "https://www.uniprot.org/uniprotkb/Q3T110-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRKCGSCLSSLLIPLALWSIIVNILLYFPNGQASYASSNKLTNYVWYFEGICFSGIMMLVVAAVLLVLENDNNYKCCQSENCSKKYMTVLSMIFSALGIAFSGYCLVISALGLLQGPYCRTLDGWEYAFEGTAGRFLTDSREWIQCLEPAHVVEWNIILFSILIALSGLQVIVCLIRVVIQLSKSLCGTYSVIIQPGII", "length": 201, "header": "sp|Q3T110-1|T4S18_BOVIN Isoform 1 of Transmembrane 4 L6 family member 18 OS=Bos taurus OX=9913 GN=TM4SF18 PE=2 SV=1 CANONICAL=Q3T110-1" }, "isoforms": [ { "isoform_ac": "A0A452DIX6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T110/entry#A0A452DIX6-1", "sequence": { "sequence": "MGSRKCGSCLSSLLIPLALWSIIVNILLYFPNGQASYASSNKLTNYVWYFEGICFSGIMMLVVAAVLLVLENDNNYKCCQSENCSKKYMFPYRFQRMDSVPGTRARSGMEHHLIFYSHSSQWTSSDCLPHQSGHSVVQESLWNLFSHHPAWNHLNKDKNVFLHQDMAIYLCLLNGLEGHFQMMFFSLQMVFAVLTGMPSFLLKFFSKLYVSGSSEMFIPF", "length": 220, "header": "tr|A0A452DIX6-1|A0A452DIX6_BOVIN Computationally mapped isoform of Transmembrane 4 L six family member 18 OS=Bos taurus OX=9913 GN=TM4SF18 PE=3 SV=1 CANONICAL=Q3T110-1" }, "locus": { "chromosome": "1", "start_pos": 118883593, "end_pos": 118859511, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026585.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026585.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026585.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026585.5" } ] } }, { "isoform_ac": "Q3T110-1", "url": "https://www.uniprot.org/uniprotkb/Q3T110/entry#Q3T110-1", "sequence": { "sequence": "MGSRKCGSCLSSLLIPLALWSIIVNILLYFPNGQASYASSNKLTNYVWYFEGICFSGIMMLVVAAVLLVLENDNNYKCCQSENCSKKYMTVLSMIFSALGIAFSGYCLVISALGLLQGPYCRTLDGWEYAFEGTAGRFLTDSREWIQCLEPAHVVEWNIILFSILIALSGLQVIVCLIRVVIQLSKSLCGTYSVIIQPGII", "length": 201, "header": "sp|Q3T110-1|T4S18_BOVIN Isoform 1 of Transmembrane 4 L6 family member 18 OS=Bos taurus OX=9913 GN=TM4SF18 PE=2 SV=1 CANONICAL=Q3T110-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507280", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507280", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T110", "url": "https://www.uniprot.org/uniprotkb/Q3T110" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T110-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 201, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T110-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T110" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5BIP8-1", "uniprot_ac": "Q5BIP8", "uniprot_id": "DNJB5_BOVIN", "mass": { "chemical_mass": 39075.0, "monoisotopic_mass": 39075.0 }, "refseq": { "ac": "NP_001014959", "name": "dnaJ homolog subfamily B member 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014959" }, "gene_names": [ { "name": "DNAJB5", "type": "recommended", "evidence": [ { "id": "Q5BIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ] }, { "name": "DNAJB5", "type": "synonym", "evidence": [ { "id": "NP_001014959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014959" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily B member 5", "type": "recommended", "evidence": [ { "id": "Q5BIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily B, member 5", "type": "synonym", "evidence": [ { "id": "NP_001014959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014959" } ] }, { "name": "dnaJ homolog subfamily B member 5", "type": "synonym", "evidence": [ { "id": "NP_001014959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014959" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJB5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8", "locus": { "chromosome": "8", "start_pos": 59285442, "end_pos": 59277682, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018318", "url": "https://www.ensembl.org/id/ENSBTAG00000018318" } ] } } ], "crossref": [ { "id": "Q5BIP8", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018318", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018318", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540083", "url": "https://www.ncbi.nlm.nih.gov/gene/540083", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540083", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540083", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IVFHIVE", "url": "https://omabrowser.org/oma/group/IVFHIVE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJB8", "url": "https://www.orthodb.org/?gene=A0A452DJB8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJP9", "url": "https://www.orthodb.org/?gene=A0A452DJP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5BIP8", "url": "https://www.orthodb.org/?gene=Q5BIP8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24078:SF553", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24078:SF553", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJB8", "url": "https://www.uniprot.org/uniprotkb/A0A452DJB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJB8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJP9", "url": "https://www.uniprot.org/uniprotkb/A0A452DJP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGSSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSARPFSGFDPDDMDVDEDDDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 348, "header": "sp|Q5BIP8-1|DNJB5_BOVIN Isoform 1 of DnaJ homolog subfamily B member 5 OS=Bos taurus OX=9913 GN=DNAJB5 PE=2 SV=1 CANONICAL=Q5BIP8-1" }, "isoforms": [ { "isoform_ac": "A0A452DJB8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8/entry#A0A452DJB8-1", "sequence": { "sequence": "MFKRTVLSCPSPAAPPLQARGAFRSFPHFWGEDFLASLMFKIQLEPLKLRAWTLNGNKETSAGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGSSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSARPFSGFDPDDMDVDEDDDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 415, "header": "tr|A0A452DJB8-1|A0A452DJB8_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member B5 OS=Bos taurus OX=9913 GN=DNAJB5 PE=4 SV=2 CANONICAL=Q5BIP8-1" }, "locus": { "chromosome": "8", "start_pos": 59285328, "end_pos": 59278589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045969.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045969.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043310.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043310.4" } ] } }, { "isoform_ac": "A0A452DJP9-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8/entry#A0A452DJP9-1", "sequence": { "sequence": "MFKIQLEPLKLRAWTLNGFVKFRNKETSAGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGSSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSARPFSGFDPDDMDVDEDDDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 382, "header": "tr|A0A452DJP9-1|A0A452DJP9_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member B5 OS=Bos taurus OX=9913 GN=DNAJB5 PE=4 SV=1 CANONICAL=Q5BIP8-1" }, "locus": { "chromosome": "8", "start_pos": 59285328, "end_pos": 59278703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024375.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024375.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024375.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024375.7" } ] } }, { "isoform_ac": "Q5BIP8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8/entry#Q5BIP8-1", "sequence": { "sequence": "MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGSSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSARPFSGFDPDDMDVDEDDDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 348, "header": "sp|Q5BIP8-1|DNJB5_BOVIN Isoform 1 of DnaJ homolog subfamily B member 5 OS=Bos taurus OX=9913 GN=DNAJB5 PE=2 SV=1 CANONICAL=Q5BIP8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540083", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540083", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K9H9-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member B5", "gene_name": "Dnajb5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFKRTVLSCPPPAAPPLQARGAFRSFPHFWGEDFLASLMFKIQLEPLKLRAWTLNGFVKFRNKEPSTGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGTSGGSGGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 420 }, "evidence": [ { "id": "Q5BIP8", "url": "https://omabrowser.org/oma/group/Q5BIP8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A5WUU0-1", "protein_name": "DnaJ homolog subfamily B member 5", "gene_name": "dnajb5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGKDYYKILGIPSGSNEDEIKKAYRKMALKFHPDKNKDPNAEEKFKEIAEAYEVLSDPKKRVIYDQYGEDGLKTGGTGSSSGQGTTYHYTFHGDPHATFASFFGGSNPFDIFFGSSRQRGNTNGFPDHGDHDMDIDMDGEDDPFSSFSHFGFNGVNGFHHGGGRRHRNEPLHGGRKKLQDPPVVHELKVSLEEIFHGCTKRMRITRRRLNPDRKTMRTEDKILNIVIKRGWKEGTKITFPKEGDETPENIPADIAFVLKDKGHPLFRRDGSNIIYTTKIGLKEALCGCTVNIPTIDNRAITLPCNDIIKPGTIKRLRGEGLPFPKNPSQRGDLIVEFQVRFPDRIPPQSREIIKQHLPQS", "length": 360 }, "evidence": [ { "id": "Q5BIP8", "url": "https://omabrowser.org/oma/group/Q5BIP8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O75953-3", "protein_name": "DnaJ homolog subfamily B member 5", "gene_name": "DNAJB5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGTSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 348 }, "evidence": [ { "id": "Q5BIP8", "url": "https://omabrowser.org/oma/group/Q5BIP8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O89114-1", "protein_name": "DnaJ homolog subfamily B member 5", "gene_name": "Dnajb5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGSSGGSGGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS", "length": 348 }, "evidence": [ { "id": "Q5BIP8", "url": "https://omabrowser.org/oma/group/Q5BIP8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP8", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIP8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 348, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIP8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIP8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5BIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP8" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 68, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBB6-1", "uniprot_ac": "Q3ZBB6", "uniprot_id": "AP4S1_BOVIN", "mass": { "chemical_mass": 16991.0, "monoisotopic_mass": 16991.0 }, "refseq": { "ac": "NP_001035693", "name": "AP-4 complex subunit sigma-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" }, "gene_names": [ { "name": "AP4S1", "type": "recommended", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ] }, { "name": "AP4S1", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] } ], "protein_names": [ { "name": "AP-4 complex subunit sigma-1", "type": "recommended", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "AP-4 adapter complex subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "AP-4 adaptor complex subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" }, { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "AP-4 complex subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "Adaptor-related protein complex 4 subunit sigma-1", "type": "synonym", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "Sigma-1 subunit of AP-4", "type": "synonym", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "Sigma-4-adaptin", "type": "synonym", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "Sigma4-adaptin", "type": "synonym", "evidence": [ { "id": "Q3ZBB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#names_and_taxonomy" } ] }, { "name": "adapter-related protein complex 4 subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "adaptor related protein complex 4 sigma 1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "sigma-1 subunit of AP-4", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "sigma-4-adaptin", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] }, { "name": "sigma4-adaptin", "type": "synonym", "evidence": [ { "id": "NP_001035693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693" } ] } ], "function": [ { "annotation": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6#function" }, { "database": "UniProtKB", "id": "Q9Y587", "url": "https://www.uniprot.org/uniprotkb/Q9Y587#function" }, { "database": "UniProtKB", "id": "A0A452DJD4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJD4#function" }, { "database": "UniProtKB", "id": "ARBA00053594", "url": "https://www.uniprot.org/uniprotkb/ARBA00053594#function" }, { "database": "UniProtKB", "id": "A0AAA9TT88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP4S1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6", "locus": { "chromosome": "21", "start_pos": 41727849, "end_pos": 41649594, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017201", "url": "https://www.ensembl.org/id/ENSBTAG00000017201" } ] } } ], "crossref": [ { "id": "Q3ZBB6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017201", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017201", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14832", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14832", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618267", "url": "https://www.ncbi.nlm.nih.gov/gene/618267", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618267", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618267", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHVVETN", "url": "https://omabrowser.org/oma/group/GHVVETN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJD4", "url": "https://www.orthodb.org/?gene=A0A452DJD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBB6", "url": "https://www.orthodb.org/?gene=Q3ZBB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJD4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJD4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBB6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVEINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDDYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSDS", "length": 144, "header": "sp|Q3ZBB6-1|AP4S1_BOVIN Isoform 1 of AP-4 complex subunit sigma-1 OS=Bos taurus OX=9913 GN=AP4S1 PE=2 SV=1 CANONICAL=Q3ZBB6-1" }, "isoforms": [ { "isoform_ac": "A0A452DJD4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#A0A452DJD4-1", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVEINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDDYFSRVIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSDS", "length": 140, "header": "tr|A0A452DJD4-1|A0A452DJD4_BOVIN Computationally mapped isoform of AP complex subunit sigma OS=Bos taurus OX=9913 GN=AP4S1 PE=3 SV=1 CANONICAL=Q3ZBB6-1" }, "locus": { "chromosome": "21", "start_pos": 41697208, "end_pos": 41679370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046059.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046059.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043387.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043387.4" } ] } }, { "isoform_ac": "A0AAA9TT88-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#A0AAA9TT88-1", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVEINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDDYFSRVSELDVSFFSAVSQVFHTSWQRQASPDQVLVLALEDDPTSV", "length": 138, "header": "tr|A0AAA9TT88-1|A0AAA9TT88_BOVIN Computationally mapped isoform of AP complex subunit sigma OS=Bos taurus OX=9913 GN=AP4S1 PE=3 SV=1 CANONICAL=Q3ZBB6-1" }, "locus": { "chromosome": "21", "start_pos": 41727846, "end_pos": 41679370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115384.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115384.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100283.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100283.1" } ] } }, { "isoform_ac": "Q3ZBB6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6/entry#Q3ZBB6-1", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVEINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDDYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSDS", "length": 144, "header": "sp|Q3ZBB6-1|AP4S1_BOVIN Isoform 1 of AP-4 complex subunit sigma-1 OS=Bos taurus OX=9913 GN=AP4S1 PE=2 SV=1 CANONICAL=Q3ZBB6-1" }, "locus": { "chromosome": "21", "start_pos": 41697208, "end_pos": 41679370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070758.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070758.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060856.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060856.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618267", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618267", "resource": "KEGG Pathway" }, { "id": "R-BTA-432720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N6Z4-1", "protein_name": "AP complex subunit sigma", "gene_name": "Ap4s1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVEINKRTVLETEVIKSCLSRSSEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAVYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMLLNGCIVETNRARILAPLLILDKMSES", "length": 144 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XPJ4-1", "protein_name": "AP complex subunit sigma", "gene_name": "AP4S1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSRYYEHIEIHKRTMLEAEVIKHCLSRSKDQCSFIEYKDFKLVYRQYAALFVVVGINETENEMAVYELIHNFVEVLDKYFSRVSELDIMFNLDRVHIILDEMVLNGCIVETNPNRILAPLFVLDKVAES", "length": 144 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O82201-1", "protein_name": "AP-4 complex subunit sigma", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGIRFILMVNKQGQTRLAQYYEWLTLEERRALEGEIVRKCLARNDQQCSFVEHRNYKIVYRRYASLFFMVGVDDDENELAILEFIHLLVETMDKHFGNVCELDIMFHLEKAHFMLEEMVMNGCIVETSKANILSPIQLMDKAH", "length": 143 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54NZ4-1", "protein_name": "AP-4 complex subunit sigma", "gene_name": "ap4s1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAIKYFLLVNIRGKTRLSQYYESIPFEERPAMESEIIRKCLSRTEIQCSFVEYKDYKVIYRKYATLFFIVGVDTTENELAILELIHNYVEILDSCFDNVIMFNLDKAHFILDEMVSNGDIVEISKQHILEFVNLLYKQE", "length": 139 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9WVL1-1", "protein_name": "AP-4 complex subunit sigma-1", "gene_name": "Ap4s1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVDINKRALLETEVSKSCLSRSSEQCSFIEYKDFKLIYRQYAALFVVVGVNDTENEMAIYEFIHNFVEVLDGYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKLSES", "length": 144 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y587-1", "protein_name": "AP-4 complex subunit sigma-1", "gene_name": "AP4S1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES", "length": 144 }, "evidence": [ { "id": "Q3ZBB6", "url": "https://omabrowser.org/oma/group/Q3ZBB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" }, { "name": "AP-4 adaptor complex", "id": "GO:0030124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030124", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBB6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T025-1", "uniprot_ac": "Q3T025", "uniprot_id": "RL17_BOVIN", "mass": { "chemical_mass": 21397.0, "monoisotopic_mass": 21397.0 }, "refseq": { "ac": "NP_001029631", "name": "large ribosomal subunit protein uL22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631" }, "gene_names": [ { "name": "RPL17", "type": "recommended", "evidence": [ { "id": "Q3T025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ] }, { "name": "RPL17L", "type": "synonym", "evidence": [ { "id": "NP_001029631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631" } ] }, { "name": "RPL17", "type": "synonym", "evidence": [ { "id": "NP_001029631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL22", "type": "recommended", "evidence": [ { "id": "Q3T025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L17", "type": "synonym", "evidence": [ { "id": "NP_001029631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631" }, { "id": "Q3T025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL22", "type": "synonym", "evidence": [ { "id": "NP_001029631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025#function" }, { "database": "UniProtKB", "id": "P18621", "url": "https://www.uniprot.org/uniprotkb/P18621#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL17", "url": "https://www.uniprot.org/uniprotkb/Q3T025", "locus": { "chromosome": "24", "start_pos": 49149781, "end_pos": 49154341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022902", "url": "https://www.ensembl.org/id/ENSBTAG00000022902" } ] } } ], "crossref": [ { "id": "Q3T025", "url": "https://alphafold.ebi.ac.uk/entry/Q3T025", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022902", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022902", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00336", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00336", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514046", "url": "https://www.ncbi.nlm.nih.gov/gene/514046", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018260", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018260", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057265", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057265", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514046", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514046", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NTYETAR", "url": "https://omabrowser.org/oma/group/NTYETAR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJF6", "url": "https://www.orthodb.org/?gene=A0A452DJF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T025", "url": "https://www.orthodb.org/?gene=Q3T025", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11593:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11593:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11593:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11593:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029631", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJF6", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T025-1", "url": "https://www.uniprot.org/uniprotkb/Q3T025-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184, "header": "sp|Q3T025-1|RL17_BOVIN Isoform 1 of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN=RPL17 PE=2 SV=3 CANONICAL=Q3T025-1" }, "isoforms": [ { "isoform_ac": "A0A452DJF6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#A0A452DJF6-1", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKVN", "length": 171, "header": "tr|A0A452DJF6-1|A0A452DJF6_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN=RPL17 PE=3 SV=1 CANONICAL=Q3T025-1" }, "locus": {} }, { "isoform_ac": "A0AAA9SB94-1", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#A0AAA9SB94-1", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 176, "header": "tr|A0AAA9SB94-1|A0AAA9SB94_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3T025-1" }, "locus": { "chromosome": "21", "start_pos": 55092578, "end_pos": 55092027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127652.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127652.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082652.1" } ] } }, { "isoform_ac": "A0AAA9TXH3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#A0AAA9TXH3-1", "sequence": { "sequence": "TVSCSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 175, "header": "tr|A0AAA9TXH3-1|A0AAA9TXH3_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN=RPL17 PE=3 SV=1 CANONICAL=Q3T025-1" }, "locus": { "chromosome": "24", "start_pos": 49153498, "end_pos": 49149814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104446.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104446.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101910.1" } ] } }, { "isoform_ac": "Q3T025-1", "url": "https://www.uniprot.org/uniprotkb/Q3T025/entry#Q3T025-1", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184, "header": "sp|Q3T025-1|RL17_BOVIN Isoform 1 of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN=RPL17 PE=2 SV=3 CANONICAL=Q3T025-1" }, "locus": { "chromosome": "24", "start_pos": 49153438, "end_pos": 49149814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055065.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055065.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050222.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050222.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514046", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514046", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PR40-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "LOC107049046", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287B386-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "RPL17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKVNFLSVFTFSLLDLWLL", "length": 186 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HMS8-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "LOC100769775", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P05740-1", "protein_name": "Large ribosomal subunit protein uL22A", "gene_name": "RPL17A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKVVRLTSRQRGRIAAQKRIAA", "length": 184 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P18621-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "RPL17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P51413-1", "protein_name": "Large ribosomal subunit protein uL22y", "gene_name": "RPL17B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVKYSQEPDNQTKSCKARGSDLRVHFKNTRETAHAIRKLPLIKAKRYLEDVIAHKQAIPFTRFCRGVGRTAQAKNRHSNGQGRWPAKSAQFVLDLLKNAESNAEVKGLDVDALFISHIQVNQAAKQRRRTYRAHGRINPYMSNPCHIELILSEKEEPVKKEPETQLAAKSKKSAA", "length": 175 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54NG2-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "rpl17", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTKPVYSKTPSNPEKSCKSRGSNLRIHFKNTRESAMAIKGMLLTRAKAYLNNVLAHRECIPFRRFKGGVGRTGQAKIFGTSQGRWPKKSVEHILSLLQNAEANAEAKGLNVEKLKIAHVQVQRAQQQRRRTYRAHGRINPYMCSPSTVEFILTEVEKAVPKPAEESAQKKKSVATQEISA", "length": 180 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CPR4-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "Rpl17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "Q3T025", "url": "https://omabrowser.org/oma/group/Q3T025/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" }, { "name": "large ribosomal subunit", "id": "GO:0015934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015934", "evidence": [ { "database": "UniProtKB", "id": "Q3T025", "url": "https://www.uniprot.org/uniprotkb/Q3T025" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T025-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T025-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T025" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PA8-1", "uniprot_ac": "Q32PA8", "uniprot_id": "AAMDC_BOVIN", "mass": { "chemical_mass": 13388.0, "monoisotopic_mass": 13388.0 }, "refseq": { "ac": "NP_001032550", "name": "mth938 domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" }, "gene_names": [ { "name": "AAMDC", "type": "recommended", "evidence": [ { "id": "Q32PA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA8" } ] }, { "name": "AAMDC", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] }, { "name": "C11orf67", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] }, { "name": "C29H11orf67", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] } ], "protein_names": [ { "name": "Mth938 domain-containing protein", "type": "recommended", "evidence": [ { "id": "Q32PA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA8/entry#names_and_taxonomy" } ] }, { "name": "UPF0366 protein C11orf67 homolog", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] }, { "name": "adipogenesis associated Mth938 domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] }, { "name": "mth938 domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001032550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550" } ] } ], "function": [ { "annotation": "May play a role in preadipocyte differentiation and adipogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32PA8", "url": "https://www.uniprot.org/uniprotkb/Q32PA8#function" }, { "database": "UniProtKB", "id": "A0AAA9T6Q3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q3#function" }, { "database": "UniProtKB", "id": "ARBA00057418", "url": "https://www.uniprot.org/uniprotkb/ARBA00057418#function" }, { "database": "UniProtKB", "id": "A0AAA9RUF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUF5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PA8", "url": "https://www.uniprot.org/uniprotkb/Q32PA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AAMDC", "url": "https://www.uniprot.org/uniprotkb/Q32PA8", "locus": { "chromosome": "29", "start_pos": 18116012, "end_pos": 18188541, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017298", "url": "https://www.ensembl.org/id/ENSBTAG00000017298" } ] } } ], "crossref": [ { "id": "Q32PA8", "url": "https://alphafold.ebi.ac.uk/entry/Q32PA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05126", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05126", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533224", "url": "https://www.ncbi.nlm.nih.gov/gene/533224", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533224", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533224", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AEYNKMA", "url": "https://omabrowser.org/oma/group/AEYNKMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PA8", "url": "https://www.orthodb.org/?gene=Q32PA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15811", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15811", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15811:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15811:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04430", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04430", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PA8", "url": "https://www.uniprot.org/uniprotkb/Q32PA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PA8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRDWDWRETGTEHSPGVQPADVEEVVEKGVQILVIGRGMSEALKVPPSTVEYLKKKGIDVRVLQTEQAVKEYNALATQGIRVGGVFHSTC", "length": 122, "header": "sp|Q32PA8-1|AAMDC_BOVIN Isoform 1 of Mth938 domain-containing protein OS=Bos taurus OX=9913 GN=AAMDC PE=2 SV=1 CANONICAL=Q32PA8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUF5-1", "url": "https://www.uniprot.org/uniprotkb/Q32PA8/entry#A0AAA9RUF5-1", "sequence": { "sequence": "MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRDWDWRETGTEGLCPQGLPSPTPQETLQNQQEGLGQSSIKLLLLPLVQHSPGVQPADVEEVVEKGVQILVIGRGMSEALKVPPSTVEYLKKKGIDVRVLQTEQAVKEYNALATQGIRVGGVFHSTC", "length": 159, "header": "tr|A0AAA9RUF5-1|A0AAA9RUF5_BOVIN Computationally mapped isoform of Mth938 domain-containing protein OS=Bos taurus OX=9913 GN=AAMDC PE=3 SV=1 CANONICAL=Q32PA8-1" }, "locus": { "chromosome": "29", "start_pos": 18179812, "end_pos": 18154941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112846.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112846.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074700.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074700.1" } ] } }, { "isoform_ac": "A0AAA9T6Q3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PA8/entry#A0AAA9T6Q3-1", "sequence": { "sequence": "MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRDWDWRETGTEHSPGVQPADVEEVVEKGVQILVIGRGMSEALKVGLRRQLNLDLQ", "length": 88, "header": "tr|A0AAA9T6Q3-1|A0AAA9T6Q3_BOVIN Computationally mapped isoform of Mth938 domain-containing protein OS=Bos taurus OX=9913 GN=AAMDC PE=3 SV=1 CANONICAL=Q32PA8-1" }, "locus": { "chromosome": "29", "start_pos": 18179812, "end_pos": 18116012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110839.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110839.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093574.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093574.1" } ] } }, { "isoform_ac": "Q32PA8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PA8/entry#Q32PA8-1", "sequence": { "sequence": "MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRDWDWRETGTEHSPGVQPADVEEVVEKGVQILVIGRGMSEALKVPPSTVEYLKKKGIDVRVLQTEQAVKEYNALATQGIRVGGVFHSTC", "length": 122, "header": "sp|Q32PA8-1|AAMDC_BOVIN Isoform 1 of Mth938 domain-containing protein OS=Bos taurus OX=9913 GN=AAMDC PE=2 SV=1 CANONICAL=Q32PA8-1" }, "locus": { "chromosome": "29", "start_pos": 18179812, "end_pos": 18154941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022993.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022993.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022993.2", "url": "https://www.ensembl.org/id/ENSBTAP00000022993.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533224", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533224", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NUM3-1", "protein_name": "Mth938 domain-containing protein", "gene_name": "AAMDC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSPEIASLSWGQMKVKGCSTTYKDCKVWPGGSRTWDWRETGTNHSPGVQPADLEEVVKKGVKTLVIGRGMSEALQVPPSTVDYLKKNGIDVLVLQTEKAVAEYNALAAQGVKVGGVFHSTC", "length": 122 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6GHU8-1", "protein_name": "Mth938 domain-containing protein", "gene_name": "Aamdc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASGQADMVLEEPRVLHLDPKISVHMLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETGTEHSPGVQPADVKEVAEKGVQTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQAVKEYNALAARGIRVGGVFHSTC", "length": 150 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8W4FEE0-1", "protein_name": "Adiposis associated Mth938 domain containing", "gene_name": "AAMDC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRAWDWRETGTEVPVSTVEYLKKKGIDVRVLQTEQAVKEYNALVTQGLRVGGVFHSTC", "length": 90 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q502H1-1", "protein_name": "Mth938 domain-containing protein", "gene_name": "aamdc", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSPEIASLSWGHMKVKGCSTSYKDCKVWPGGSRAWDWRETGTNHHPGVQPSDLEEILRKGVQTLVIGRGMSEALQVPPSTLDYVKKQGVDVQVFQTEQAVREYNALAGKGEKVGGVFHSTC", "length": 122 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8R0P4-1", "protein_name": "Mth938 domain-containing protein", "gene_name": "Aamdc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETGTEHSPGVQPADVKEVAEKGVQTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHSTC", "length": 122 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H7C9-1", "protein_name": "Mth938 domain-containing protein", "gene_name": "AAMDC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSPEIASLSWGQMKVKGSNTTYKDCKVWPGGSRTWDWRETGTEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHSTC", "length": 122 }, "evidence": [ { "id": "Q32PA8", "url": "https://omabrowser.org/oma/group/Q32PA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PA8", "url": "https://www.uniprot.org/uniprotkb/Q32PA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of fat cell differentiation", "id": "GO:0045600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "evidence": [ { "database": "UniProtKB", "id": "Q32PA8", "url": "https://www.uniprot.org/uniprotkb/Q32PA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 122, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PA8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZT4-1", "uniprot_ac": "Q3SZT4", "uniprot_id": "TEX29_BOVIN", "mass": { "chemical_mass": 16331.0, "monoisotopic_mass": 16331.0 }, "refseq": { "ac": "NP_001069929", "name": "testis-expressed protein 29", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" }, "gene_names": [ { "name": "TEX29", "type": "recommended", "evidence": [ { "id": "Q3SZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4" } ] }, { "name": "C12H13orf16", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] }, { "name": "C13orf16", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] }, { "name": "TEX29", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] } ], "protein_names": [ { "name": "Testis-expressed protein 29", "type": "recommended", "evidence": [ { "id": "Q3SZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4/entry#names_and_taxonomy" } ] }, { "name": "testis-expressed protein 29", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] }, { "name": "testis-expressed sequence 29 protein", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] }, { "name": "uncharacterized protein C13orf16 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZT4", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEX29", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4", "locus": { "chromosome": "12", "start_pos": 85552388, "end_pos": 85542292, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007298", "url": "https://www.ensembl.org/id/ENSBTAG00000007298" } ] } } ], "crossref": [ { "id": "Q3SZT4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617473", "url": "https://www.ncbi.nlm.nih.gov/gene/617473", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617473", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617473", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EPEFKKS", "url": "https://omabrowser.org/oma/group/EPEFKKS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZT4", "url": "https://www.orthodb.org/?gene=Q3SZT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37339:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37339:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069929", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT4", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRYAPEFKKSPSHLLKKFAVCDIPLYDICDYNVSRDRCKELGCCFYKGICYEKAVPSYVQVFSALIVIIAGAFVITIIYRVIQESRREKEVPTEAPVSAKSSVQVETQPPSSAGAGSKAPSVERPQSKESGREDASLIVTEEEETED", "length": 147, "header": "sp|Q3SZT4-1|TEX29_BOVIN Isoform 1 of Testis-expressed protein 29 OS=Bos taurus OX=9913 GN=TEX29 PE=2 SV=1 CANONICAL=Q3SZT4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUW2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4/entry#A0AAA9RUW2-1", "sequence": { "sequence": "NPGLSLTRTRGQNQGETVQVPPRGAPRPRGRGSCPSVVRVPSWLAEGGPASVRREGWPPGPACYVQVFSALIVIIAGAFVITIIYRVIQESRREKEVPTEAPVSAKSSVQVETQPPSSAGAGSKAPSVERPQSKESGREDASLIVTEEEETED", "length": 153, "header": "tr|A0AAA9RUW2-1|A0AAA9RUW2_BOVIN Computationally mapped isoform of Testis expressed 29 OS=Bos taurus OX=9913 GN=TEX29 PE=4 SV=1 CANONICAL=Q3SZT4-1" }, "locus": { "chromosome": "12", "start_pos": 85552259, "end_pos": 85549629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091247.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091247.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077044.1" } ] } }, { "isoform_ac": "A0AAA9TIV7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4/entry#A0AAA9TIV7-1", "sequence": { "sequence": "DALPRGQRPDHELGRSRSDPDLGGRVPLQCPVQRSPRECLHHCVHTGGYVQVFSALIVIIAGAFVITIIYRVIQESRREKEVPTEAPVSAKSSVQVETQPPSSAGAGSKAPSVERPQSKESGREDASLIVTEEEETED", "length": 138, "header": "tr|A0AAA9TIV7-1|A0AAA9TIV7_BOVIN Computationally mapped isoform of Testis expressed 29 OS=Bos taurus OX=9913 GN=TEX29 PE=4 SV=1 CANONICAL=Q3SZT4-1" }, "locus": { "chromosome": "12", "start_pos": 85552259, "end_pos": 85548919, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120352.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120352.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097086.1" } ] } }, { "isoform_ac": "Q3SZT4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4/entry#Q3SZT4-1", "sequence": { "sequence": "MRYAPEFKKSPSHLLKKFAVCDIPLYDICDYNVSRDRCKELGCCFYKGICYEKAVPSYVQVFSALIVIIAGAFVITIIYRVIQESRREKEVPTEAPVSAKSSVQVETQPPSSAGAGSKAPSVERPQSKESGREDASLIVTEEEETED", "length": 147, "header": "sp|Q3SZT4-1|TEX29_BOVIN Isoform 1 of Testis-expressed protein 29 OS=Bos taurus OX=9913 GN=TEX29 PE=2 SV=1 CANONICAL=Q3SZT4-1" }, "locus": { "chromosome": "12", "start_pos": 85552259, "end_pos": 85542495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009602.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009602.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009602.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009602.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617473", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617473", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8N6K0-1", "protein_name": "Testis-expressed protein 29", "gene_name": "TEX29", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEYVLEVKNSPRHLLKQFTVCDVPLYDICDYNVSRDRCQELGCCFYEGVCYKKAVPIYIHVFSALIVIIAGAFVITIIYRVIQESRKEKAIPVDVALPQKSSEKAELASSSSKLGLKPASPGPPSAGPSMKSDEDKDDVTGTITEAEETED", "length": 151 }, "evidence": [ { "id": "Q3SZT4", "url": "https://omabrowser.org/oma/group/Q3SZT4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT4", "url": "https://www.uniprot.org/uniprotkb/Q3SZT4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZT4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 147, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZT4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZT4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5BIM2-1", "uniprot_ac": "Q5BIM2", "uniprot_id": "ATOSB_BOVIN", "mass": { "chemical_mass": 56511.0, "monoisotopic_mass": 56511.0 }, "refseq": { "ac": "NP_001014893", "name": "atos homolog protein B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" }, "gene_names": [ { "name": "ATOSB", "type": "recommended", "evidence": [ { "id": "Q5BIM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ] }, { "name": "ATOSB", "type": "synonym", "evidence": [ { "id": "NP_001014893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" } ] }, { "name": "FAM214B", "type": "synonym", "evidence": [ { "id": "NP_001014893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" }, { "id": "Q5BIM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ] } ], "protein_names": [ { "name": "Atos homolog protein B", "type": "recommended", "evidence": [ { "id": "Q5BIM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2/entry#names_and_taxonomy" } ] }, { "name": "atos homolog protein B", "type": "synonym", "evidence": [ { "id": "NP_001014893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" } ] }, { "name": "family with sequence similarity 214 member B", "type": "synonym", "evidence": [ { "id": "NP_001014893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" } ] }, { "name": "protein FAM214B", "type": "synonym", "evidence": [ { "id": "NP_001014893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893" } ] } ], "function": [ { "annotation": "Transcription regulator that may syncronize transcriptional and translational programs.", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2#function" }, { "database": "UniProtKB", "id": "Q8BR27", "url": "https://www.uniprot.org/uniprotkb/Q8BR27#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATOSB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2", "locus": { "chromosome": "8", "start_pos": 59362626, "end_pos": 59373750, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011394", "url": "https://www.ensembl.org/id/ENSBTAG00000011394" } ] } } ], "crossref": [ { "id": "Q5BIM2", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011394", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011394", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510325", "url": "https://www.ncbi.nlm.nih.gov/gene/510325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510325", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510325", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVVEQRG", "url": "https://omabrowser.org/oma/group/CVVEQRG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIM2", "url": "https://www.orthodb.org/?gene=Q5BIM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13199:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13199:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13889", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13889", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13915", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13915", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AC72", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AC72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AC72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AC72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIM2-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHVQAETSPSSEPEAGPSQPAVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGASEPPRALKRPAPPTEGPRELKRGPGLGAREGLSPEEPPTVGLLGPEGLGLKLGVASQHFCHHGLCVVEQGGSSTSPWTSGARSSPLPPSNASCSTLHTRDWASPDPRGQGSLGSSLGPAPPGQLHTLDTDLHSLAQIGGKSLVSGVGNGGSPWPRESPGTANGCSPEHTPPGPGPPGPCPTKRRLLPAGEALDVSSEDEGPAPRRRRGTLGHPPAANSSDAKATPFWSHLLPGPKEPVLDPTDCNPMGRRLKGARRLKLSSLRSLRKGPGLLSPPSASPVPAPAVSRTLLGNFEESLLRGRFAPSGRIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLSPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNAGPTRRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP", "length": 538, "header": "sp|Q5BIM2-1|ATOSB_BOVIN Isoform 1 of Atos homolog protein B OS=Bos taurus OX=9913 GN=ATOSB PE=2 SV=1 CANONICAL=Q5BIM2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUX0-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2/entry#A0AAA9RUX0-1", "sequence": { "sequence": "MRHVQAETSPSSEPEAGPSQPAVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGASEPPRALKRPAPPTEGPRELKRGPGLGAREGLSPEEPPTVGLLGPEGLGLKLGVASQHFCHHGLCVVEQGGSSTSPWTSGARSSPLPPSNASCSTLHTRDWASPDPRGQGSLGSSLGPAPPGQLHTLDTDLHSLAQIGGPCPTKRRLLPAGEALDVSSEDEGPAPRRRRGTLGHPPAANSSDAKATPFWSHLLPGPKEPVLDPTDCNPMGRRLKGARRLKLSSLRSLRKGPGLLSPPSASPVPAPAVSRTLLGNFEESLLRGRFAPSGRIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLSPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNAGPTRRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP", "length": 500, "header": "tr|A0AAA9RUX0-1|A0AAA9RUX0_BOVIN Computationally mapped isoform of Atos homolog protein B OS=Bos taurus OX=9913 GN=ATOSB PE=3 SV=1 CANONICAL=Q5BIM2-1" }, "locus": { "chromosome": "8", "start_pos": 59365904, "end_pos": 59363341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126689.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126689.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076010.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076010.1" } ] } }, { "isoform_ac": "A0AAF7AC72-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2/entry#A0AAF7AC72-1", "sequence": { "sequence": "MRHVQAETSPSSEPEAGPSQPAVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGASEPPRALKRPAPPTEGPRELKRGPGLGAREGLSPEEPPTVGLLGPEGLGLKLGVASQHFCHHGLCVVEQGGSSTSPWTSGARSSPLPPSNASCSTLHTRDWASPDPRGQGSLGSSLGPAPPGQLHTLDTDLHSLAQIGGKSLVSGVGNGGSPWPRESPGTANGCSPEHTPPGPGPPGPCPTKRRLLPAGEALDVSSEDEGPAPRRRRGTLGHPPAANSSDAKATPFWSHLLPGPKEPVLDPTDCNPMGRRLKGARRLKLSSLRSLRKGPGLLSPPSASPVPAPAVSRTLLGNFEESLLRGRFAPSGRIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLSPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNAGPTRRLLCYLLHLR", "length": 488, "header": "tr|A0AAF7AC72-1|A0AAF7AC72_BOVIN Computationally mapped isoform of Atos homolog B OS=Bos taurus OX=9913 GN=ATOSB PE=4 SV=1 CANONICAL=Q5BIM2-1" }, "locus": { "chromosome": "8", "start_pos": 59365904, "end_pos": 59363630, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073509.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073509.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066676.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066676.2" } ] } }, { "isoform_ac": "Q5BIM2-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2/entry#Q5BIM2-1", "sequence": { "sequence": "MRHVQAETSPSSEPEAGPSQPAVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGASEPPRALKRPAPPTEGPRELKRGPGLGAREGLSPEEPPTVGLLGPEGLGLKLGVASQHFCHHGLCVVEQGGSSTSPWTSGARSSPLPPSNASCSTLHTRDWASPDPRGQGSLGSSLGPAPPGQLHTLDTDLHSLAQIGGKSLVSGVGNGGSPWPRESPGTANGCSPEHTPPGPGPPGPCPTKRRLLPAGEALDVSSEDEGPAPRRRRGTLGHPPAANSSDAKATPFWSHLLPGPKEPVLDPTDCNPMGRRLKGARRLKLSSLRSLRKGPGLLSPPSASPVPAPAVSRTLLGNFEESLLRGRFAPSGRIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLSPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNAGPTRRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP", "length": 538, "header": "sp|Q5BIM2-1|ATOSB_BOVIN Isoform 1 of Atos homolog protein B OS=Bos taurus OX=9913 GN=ATOSB PE=2 SV=1 CANONICAL=Q5BIM2-1" }, "locus": { "chromosome": "8", "start_pos": 59365904, "end_pos": 59363341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015139.4", "url": "https://www.ensembl.org/id/ENSBTAT00000015139.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015139.2", "url": "https://www.ensembl.org/id/ENSBTAP00000015139.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ], "site_lbl": "Ser254" }, { "start_pos": 255, "end_pos": 255, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ], "site_lbl": "Ser255" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510325", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510325", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5PQM8-1", "protein_name": "Atos homolog protein B", "gene_name": "Atosb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRHVQAELSPSSEPEAGPSQPPVTQGTLQGGLLMGYSPAGGATSPGVYQVSIFSPSAGVSEPPRALKRPAPSTEGPRELKRGPGLGAREGLPPEEPSTVGLVSPEGLGLGLGVASQHFSHHGLRVVEQGGSATSSWTSGTQSTPWPSSNASCNTLHTRDWAFPDQGGQGCLGESPGPAPSGQLHTLDTDLHNLAQIGGKSPVARVGNGSNPWPRESHGTANGHSPEHTPPGPGPPGPCPTKRRLLPAGEALDVSSEDEGPAPRRRRGTLGCPLAANSSDAKATPFWSHLLPGPKEPVLDPTDRSPMGRRLKGARRLKLSSLRTLRKGPGLLSPPSASPFPTPAVSRTLLGNFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLNPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNVSPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP", "length": 538 }, "evidence": [ { "id": "Q5BIM2", "url": "https://omabrowser.org/oma/group/Q5BIM2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7L5A3-1", "protein_name": "Atos homolog protein B", "gene_name": "ATOSB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRHVQAEPSPSSEPEAGPSQPPVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGTSEPHRALKRQAPSTEGPRELKRGPGLGAREGLPPEEPSTVGLLGPEGPGLGLGVASQHFSHRGLCVVEQRSSVTSSWTSGAWSPPCPPSNASCNTLHTRDWASPDPGGQGSLGESPGPAPPGQLHTLDTDLHSLAQIGGKSPVAGVGNGGSLWPRESPGTANGHSPEHTPPGPGPPGPCPTKRRLLPAGEAPDVSSEEEGPAPRRRRGSLGHPTAANSSDAKATPFWSHLLPGPKEPVLDPTDCGPMGRRLKGARRLKLSPLRSLRKGPGLLSPPSASPVPTPAVSRTLLGNFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGIVDLNPLGRKGYSVPKVGTVQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNANPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP", "length": 538 }, "evidence": [ { "id": "Q5BIM2", "url": "https://omabrowser.org/oma/group/Q5BIM2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM2", "url": "https://www.uniprot.org/uniprotkb/Q5BIM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIM2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 538, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIM2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIM2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 254, 255 ], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 435, "end_pos": 437 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32LN6-1", "uniprot_ac": "Q32LN6", "uniprot_id": "S31F3_BOVIN", "mass": { "chemical_mass": 45146.0, "monoisotopic_mass": 45146.0 }, "refseq": { "ac": "NP_001070498", "name": "protein SPATA31F3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" }, "gene_names": [ { "name": "FAM205C", "type": "recommended", "evidence": [ { "id": "Q32LN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ] }, { "name": "SPATA31F3", "type": "recommended", "evidence": [ { "id": "Q32LN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ] }, { "name": "FAM205CP", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" } ] }, { "name": "FAM205C", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" }, { "id": "Q32LN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ] }, { "name": "SPATA31F3", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" } ] } ], "protein_names": [ { "name": "Protein SPATA31F3", "type": "recommended", "evidence": [ { "id": "Q32LN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM205C", "type": "synonym", "evidence": [ { "id": "Q32LN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#names_and_taxonomy" } ] }, { "name": "protein FAM205CP homolog", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" } ] }, { "name": "protein SPATA31F3", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" } ] }, { "name": "transmembrane protein ENSP00000340100 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LN6", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA31F3", "url": "https://www.uniprot.org/uniprotkb/Q32LN6", "locus": {} } ], "crossref": [ { "id": "Q32LN6", "url": "https://alphafold.ebi.ac.uk/entry/Q32LN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017338", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017338", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767962", "url": "https://www.ncbi.nlm.nih.gov/gene/767962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FSHWINP", "url": "https://omabrowser.org/oma/group/FSHWINP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LN6", "url": "https://www.orthodb.org/?gene=Q32LN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21859:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21859:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15371", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15371", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070498", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LN6", "url": "https://www.uniprot.org/uniprotkb/Q32LN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LN6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSPTFILWDVGYPFYTYGSIIIIALIIWQVKKNHRGLKLGPNRNCCRRHQKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQEAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 408, "header": "sp|Q32LN6-1|S31F3_BOVIN Isoform 1 of Protein SPATA31F3 OS=Bos taurus OX=9913 GN=SPATA31F3 PE=2 SV=1 CANONICAL=Q32LN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVK5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#A0AAA9RVK5-1", "sequence": { "sequence": "MRLRGMAGGPRLHLGSSARPDEPWVRVPVFALHQRQTLRRPDCGSPDARGKGWAEGEWLRGSQTHGAWSRGQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 394, "header": "tr|A0AAA9RVK5-1|A0AAA9RVK5_BOVIN Computationally mapped isoform of Family with sequence similarity 205 member C OS=Bos taurus OX=9913 GN=FAM205C PE=3 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59246137, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126645.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126645.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077385.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077385.1" } ] } }, { "isoform_ac": "A0AAA9S8I7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#A0AAA9S8I7-1", "sequence": { "sequence": "MSLHWQANSQPLDHQESPDSTLNKKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQEAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 381, "header": "tr|A0AAA9S8I7-1|A0AAA9S8I7_BOVIN Computationally mapped isoform of Family with sequence similarity 205 member C OS=Bos taurus OX=9913 GN=FAM205C PE=3 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59183479, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095582.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095582.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078469.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078469.1" } ] } }, { "isoform_ac": "A0AAA9SA23-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#A0AAA9SA23-1", "sequence": { "sequence": "MRLRGMAGGPRLHLGSSARPDEPWVRVPVFALHQRQTLRRPDCGSPDARGKRHQKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 410, "header": "tr|A0AAA9SA23-1|A0AAA9SA23_BOVIN Computationally mapped isoform of Family with sequence similarity 205 member C OS=Bos taurus OX=9913 GN=FAM205C PE=3 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59246137, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082931.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082931.1" } ] } }, { "isoform_ac": "A0AAA9T1E1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#A0AAA9T1E1-1", "sequence": { "sequence": "MRPLPVPPAQWLSRSALPPAPAWGGIELMSLHWQANSQPLDHQESPDSTLNKRHQKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQEAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 412, "header": "tr|A0AAA9T1E1-1|A0AAA9T1E1_BOVIN Computationally mapped isoform of Family with sequence similarity 205 member C OS=Bos taurus OX=9913 GN=FAM205C PE=3 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59245937, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108518.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108518.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091520.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091520.1" } ] } }, { "isoform_ac": "A0AAA9TMA9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#A0AAA9TMA9-1", "sequence": { "sequence": "MRLRGMAGGPRLHLGSSARPDEPWVRVPVFALHQRQTLRRPDCGSPDARGKGIFPTLGWSPHFLCLLRWQKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQEAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 427, "header": "tr|A0AAA9TMA9-1|A0AAA9TMA9_BOVIN Computationally mapped isoform of Family with sequence similarity 205 member C OS=Bos taurus OX=9913 GN=FAM205C PE=3 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59246137, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100044.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100044.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097449.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097449.1" } ] } }, { "isoform_ac": "Q32LN6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN6/entry#Q32LN6-1", "sequence": { "sequence": "MLSPTFILWDVGYPFYTYGSIIIIALIIWQVKKNHRGLKLGPNRNCCRRHQKVKQRAKEKTPRARRHSRKEADKPLELLSIMRSQGWLPQEGSVRRLLCADPCCQICNSVALEIQQLISGETTLTTPTSSGPSQGSSCLEVLSMSSLSFDQSQESLPFKQLSLPSATRTVSQLTNQKSVTQSAAKSATKPATKSVSAISIRQYWAGHQQLRQECRGPELPLDAGALSSSSVEEPRIPVNQHVKKKSNSEGILKKQEAVEADLGNKLKHFTQWINPDMKGQGRKECILRCKDEKVAKTKTKKAEKSPPSTKRPMKGAKLEKEEGFFDALQCLDSEFQRQSMESVRSSQSCFLPLSSGSSKRSPLLTCATQPENPSHVSVSTSAEGTCLPQESTQSRKKELRGSQTSASS", "length": 408, "header": "sp|Q32LN6-1|S31F3_BOVIN Isoform 1 of Protein SPATA31F3 OS=Bos taurus OX=9913 GN=SPATA31F3 PE=2 SV=1 CANONICAL=Q32LN6-1" }, "locus": { "chromosome": "8", "start_pos": 59182106, "end_pos": 59176768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036647.3", "url": "https://www.ensembl.org/id/ENSBTAT00000036647.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036503.2", "url": "https://www.ensembl.org/id/ENSBTAP00000036503.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LN6", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ], "site_lbl": "Ser152" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767962", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I398-1", "protein_name": "Protein FAM205C", "gene_name": "Fam205c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSPTFILWDMGYPLYTYGSIFIIALIIWHVKRSHRELRLGPDKSCYKCYRKVKQRPKDRTSRAKRTSKEEAEKLQKLLSIMKSQGWLPQEGSVRKLLCSDPSCPICNAMALEIQQLLGGENKKTSSTPLRPSQSFACLESLSTSKTFDKNPELCSQYSRDISLVSSLTPSQSTDQKSSTQSAAPSTGDANIRYYCPDHQQKQGPQGSNVSRDAGSLSSSSVEEPGVPANQQKKRKKNKKHVLKKEEPPEAEAENKMTFFSHWVNPEVKCARPEEPIVLSKSEAKPKTKVPEKSQTPVRDHKERANTEQTMKDLKAKPLSAKKTN", "length": 325 }, "evidence": [ { "id": "Q32LN6", "url": "https://omabrowser.org/oma/group/Q32LN6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A6NFA0-1", "protein_name": "Protein SPATA31F3", "gene_name": "SPATA31F3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSPTFVLWDVGYPLYTYGSICIIALIIWQVKKSCQKLSLVPNRSCCRCHRRVQQKSGDRTSRARRTSQEEAEKLWKLLFLMKSQGWLPQEGSVRRILCADPCCQICNVMALEIKQLLAGENNQISLTSLGPSQGSSCLEALSTSSVSFKHSQDLGSPKSKELSLASVTPTLSQLMDQKSLTQSAARSAGADSVQDSWADHFQRGQRSQVPAVSQVMGSLSSNFEKPGIPLSQQERTKNNSKFVLENQEAPEVGLDNKMKLFLHWINPEMKDRRHEESILLSKAETVTQDRTKNIEKSPTVTKDHVWGATTQKTTEDPEAQPPSTEEEGLIFCDAPSA", "length": 338 }, "evidence": [ { "id": "Q32LN6", "url": "https://omabrowser.org/oma/group/Q32LN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q642A3-1", "protein_name": "Protein SPATA31F3", "gene_name": "Spata31f3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLIPPFILWDVGYSVYTYGSIFIIALIIWQVKRSHRGLRMGPTKSCAKCFRRIKQTPSDRATRAKRTSKEEAEKLQKLLDTMKSQGWLPQEGSVRRLLCPDPSCSICNAMTLEIQQLLGVENKKTSSSLLRPSRSFSCLEALSPSKSLADRSSELTYQDTRDVSLSSRFPQSQETDQQSTRSATPSIGDAVLQCYHSAPQQQLDPQGSKMTQDAKGLSSSSTDEPGVPANQQKKRKKTKKLALKNQAAPTEVETENKMTFFSHWVNPEVKCDRQEESLVFSKYDTGAKPMTVEPEKTHSPVRDQAEGAEKKKKPECDLKAKPLRAKRNI", "length": 329 }, "evidence": [ { "id": "Q32LN6", "url": "https://omabrowser.org/oma/group/Q32LN6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80YD3-1", "protein_name": "Protein SPATA31F3", "gene_name": "Spata31f3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMVPSFILWDVGSSVYTYGSLFIIALIIWHVRRSHRGLRLGPIKSCTKCFRRIKQKPSDRTLRVKKRTTKEETEKLQKLLSNMKRQGWLPQEGSVRRLLCSDPSCPICNAMALEIQQLLGVENKKTSSSLLRHSRSFSCLEALSPPKVLNDQSSELSKVLNGQSSELSKVLNGQSSELSKVLNDQSSELSKVLNDQSSELSSQHSKDISLPPKFMQSQSTDQKLTLSAPLSTGNTVLQCYHPAPQQQPEPQGSNAFQDVSGLSSSSMDEHGVPANQQKKRKKTKKLVSKNQAAPSEAEMENKMTFFSHWVNPEVKCDRPEESFAFYKSETGAKPKTGEPKKSSAKVRAEEPNLEKHAKDLKAKPLHAKRNI", "length": 371 }, "evidence": [ { "id": "Q32LN6", "url": "https://omabrowser.org/oma/group/Q32LN6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32LN6", "url": "https://www.uniprot.org/uniprotkb/Q32LN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LN6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 408, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LN6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LN6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 152 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA39-1", "uniprot_ac": "Q2TA39", "uniprot_id": "ZMAT5_BOVIN", "mass": { "chemical_mass": 19852.0, "monoisotopic_mass": 19852.0 }, "refseq": { "ac": "NP_001033299", "name": "zinc finger matrin-type protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299" }, "gene_names": [ { "name": "ZMAT5", "type": "recommended", "evidence": [ { "id": "Q2TA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ] }, { "name": "ZMAT5", "type": "synonym", "evidence": [ { "id": "NP_001033299", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299" } ] } ], "protein_names": [ { "name": "Zinc finger matrin-type protein 5", "type": "recommended", "evidence": [ { "id": "Q2TA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#names_and_taxonomy" } ] }, { "name": "U11/U12 small nuclear ribonucleoprotein 20 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001033299", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299" }, { "id": "Q2TA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#names_and_taxonomy" } ] }, { "name": "U11/U12 snRNP 20 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001033299", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299" }, { "id": "Q2TA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#names_and_taxonomy" } ] }, { "name": "zinc finger matrin-type protein 5", "type": "synonym", "evidence": [ { "id": "NP_001033299", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZMAT5", "url": "https://www.uniprot.org/uniprotkb/Q2TA39", "locus": { "chromosome": "17", "start_pos": 68864267, "end_pos": 68887493, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017890", "url": "https://www.ensembl.org/id/ENSBTAG00000017890" } ] } } ], "crossref": [ { "id": "Q2TA39", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017890", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017890", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616095", "url": "https://www.ncbi.nlm.nih.gov/gene/616095", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616095", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616095", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPPIQEL", "url": "https://omabrowser.org/oma/group/WPPIQEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA39", "url": "https://www.orthodb.org/?gene=Q2TA39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16465:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16465:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06220", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06220", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033299", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA39-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSVQVEEERRAREWPLDVAELPEVCLEDWLEKRAKRLSSAPSSRAEPVRATVFQYPVGWPPVQELPPSLRAPPPGGWPLQPSVQWG", "length": 170, "header": "sp|Q2TA39-1|ZMAT5_BOVIN Isoform 1 of Zinc finger matrin-type protein 5 OS=Bos taurus OX=9913 GN=ZMAT5 PE=2 SV=1 CANONICAL=Q2TA39-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWR9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#A0AAA9RWR9-1", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSVQVEEERRAREWPLDVAELPEVCLEDWLEKRAKRLSSAPSSRSHYDLGGPSSTQLPQPASRELPGLTPAETLRASSPSGEPGLRPP", "length": 172, "header": "tr|A0AAA9RWR9-1|A0AAA9RWR9_BOVIN Computationally mapped isoform of Zinc finger matrin-type protein 5 OS=Bos taurus OX=9913 GN=ZMAT5 PE=4 SV=1 CANONICAL=Q2TA39-1" }, "locus": { "chromosome": "17", "start_pos": 68874974, "end_pos": 68866925, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104801.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104801.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076919.1" } ] } }, { "isoform_ac": "A0AAA9TG48-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#A0AAA9TG48-1", "sequence": { "sequence": "MGFVVLLNLGARRIELWRQWQLPARVTMGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSVQVEEERRAREWPLDVAELPEVCLEDWLEKRAKRLSSAPSSRAEPVRATVFQYPVGWPPVQELPPSLRAPPPGGWPLQPSVQWG", "length": 197, "header": "tr|A0AAA9TG48-1|A0AAA9TG48_BOVIN Computationally mapped isoform of Zinc finger matrin-type protein 5 OS=Bos taurus OX=9913 GN=ZMAT5 PE=4 SV=1 CANONICAL=Q2TA39-1" }, "locus": { "chromosome": "17", "start_pos": 68887294, "end_pos": 68864537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096241.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096241.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097150.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097150.1" } ] } }, { "isoform_ac": "Q2TA39-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA39/entry#Q2TA39-1", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSVQVEEERRAREWPLDVAELPEVCLEDWLEKRAKRLSSAPSSRAEPVRATVFQYPVGWPPVQELPPSLRAPPPGGWPLQPSVQWG", "length": 170, "header": "sp|Q2TA39-1|ZMAT5_BOVIN Isoform 1 of Zinc finger matrin-type protein 5 OS=Bos taurus OX=9913 GN=ZMAT5 PE=2 SV=1 CANONICAL=Q2TA39-1" }, "locus": { "chromosome": "17", "start_pos": 68874974, "end_pos": 68864537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023779.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023779.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023779.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023779.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616095", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616095", "resource": "KEGG Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZLD2-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "Zmat5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSEQDLQGLSVQVEVRRKTRKLRLITLPRVRDLAGATPCYHPHCLLHPQFEPLLRVKLCGHRPASSSPRLGDMPLFFKERRAREWPLETAELPEGHLEDWLEKRAKRLSSAPSSRAEPIRTTVFQYPVGWPPMQELPPSLRAPPPGGWSVQSRVQWG", "length": 233 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C1J3-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "ZMAT5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGVQHLRAKRAWYDLFRDAAAILQEEQSKKPCRKFLQTGQCDFGSNCRFSHMTEQDLEKLSAQVQGEQRLRELRQEGAEIPPGTIENWLEKRAKRLSVAQSNSALPEKPTPFQYPPGWPPLQELPPSLRAPPPGGWPVPPGLQWG", "length": 170 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RFG8-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "ZMAT5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVEEERRAREWPLEVAELPEGHLEDWLEKRAKRLSSASSSRAEPIRATVFQYPLGWPPVQELPLSLRAPPPGGWPLQPSIQWG", "length": 170 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HP14-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "Zmat5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVEEERRAREWPLETAELPEGHLEDWLEKRAKRLSSVPSSRTEPIRTTVFQYPVGWPPMQELPPSLRAPPPGGWSLQPRVQWG", "length": 170 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9CQR5-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "Zmat5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSEQDLQELSVQVEEERRAREWPLETAELPEGHLEDWLEKRAKRLSSAPSSRAEPIRTTVFQYPVGWPPMQELPPSLRAPPPGGWSVLSKVQWG", "length": 170 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UDW3-1", "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "ZMAT5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVEEERRAREWLLDAPELPEGHLEDWLEKRAKRLSSAPSSRAEPIRTTVFQYPVGWPPVQELPPSLRAPPPGGWPLQPRVQWG", "length": 170 }, "evidence": [ { "id": "Q2TA39", "url": "https://omabrowser.org/oma/group/Q2TA39/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TA39", "url": "https://www.uniprot.org/uniprotkb/Q2TA39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA39-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 170, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA39-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA39" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L76-1", "uniprot_ac": "Q32L76", "uniprot_id": "SAA4_BOVIN", "mass": { "chemical_mass": 14688.0, "monoisotopic_mass": 14688.0 }, "refseq": { "ac": "NP_001035595", "name": "serum amyloid A-4 protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035595" }, "gene_names": [ { "name": "SAA4", "type": "recommended", "evidence": [ { "id": "Q32L76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L76" } ] }, { "name": "SAA4", "type": "synonym", "evidence": [ { "id": "NP_001035595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035595" } ] } ], "protein_names": [ { "name": "Serum amyloid A-4 protein", "type": "recommended", "evidence": [ { "id": "Q32L76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L76/entry#names_and_taxonomy" } ] }, { "name": "serum amyloid A-4 protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001035595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035595" } ] }, { "name": "serum amyloid A-4 protein", "type": "synonym", "evidence": [ { "id": "NP_001035595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035595" } ] } ], "function": [ { "annotation": "Major acute phase reactant.", "evidence": [ { "database": "UniProtKB", "id": "Q32L76", "url": "https://www.uniprot.org/uniprotkb/Q32L76#function" }, { "database": "UniProtKB", "id": "P05366", "url": "https://www.uniprot.org/uniprotkb/P05366#function" } ] }, { "annotation": "Major acute phase reactant. Apolipoprotein of the HDL complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RWU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWU0#function" }, { "database": "UniProtKB", "id": "RU000539", "url": "https://www.uniprot.org/uniprotkb/RU000539#function" }, { "database": "UniProtKB", "id": "A0AAA9TZT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZT7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L76", "url": "https://www.uniprot.org/uniprotkb/Q32L76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAA4", "url": "https://www.uniprot.org/uniprotkb/Q32L76", "locus": { "chromosome": "29", "start_pos": 26482492, "end_pos": 26466153, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002963", "url": "https://www.ensembl.org/id/ENSBTAG00000002963" } ] } } ], "crossref": [ { "id": "Q32L76", "url": "https://alphafold.ebi.ac.uk/entry/Q32L76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002963", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002963", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505308", "url": "https://www.ncbi.nlm.nih.gov/gene/505308", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505308", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505308", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWFSFFK", "url": "https://omabrowser.org/oma/group/GWFSFFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L76", "url": "https://www.orthodb.org/?gene=Q32L76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23424", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23424", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23424:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23424:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00277", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00277", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L76", "url": "https://www.uniprot.org/uniprotkb/Q32L76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L76-1", "url": "https://www.uniprot.org/uniprotkb/Q32L76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLLIGILFCTLIMGVTGDSWYSFFKEAVQGASDLWRAYWDMRDANVQNSGRYFRARGNYEAAQRGPGGVWAAKIISNVGEYLQGFLYQIYLGDSYGLEDQVSNRRAEEWGRSGQDPDHFRPAGLPKKY", "length": 129, "header": "sp|Q32L76-1|SAA4_BOVIN Isoform 1 of Serum amyloid A-4 protein OS=Bos taurus OX=9913 GN=SAA4 PE=2 SV=1 CANONICAL=Q32L76-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWU0-1", "url": "https://www.uniprot.org/uniprotkb/Q32L76/entry#A0AAA9RWU0-1", "sequence": { "sequence": "MLICLHRRIEQEGHHQCTLDLRPLCPLIPKSGEIPTTEFQLEKGHSTMKLLIGILFCTLIMGVTGDSWYSFFKEAVQGASDLWRAYWDMRDANVQNSGRYFRARGNYEAAQRGPGGVWAAKIISNVGEYLQGFLYQIYLGDSYGLEDQVSNRRAEEWGRSGQDPDHFRPAGLPKKY", "length": 176, "header": "tr|A0AAA9RWU0-1|A0AAA9RWU0_BOVIN Computationally mapped isoform of Serum amyloid A protein OS=Bos taurus OX=9913 GN=SAA4 PE=3 SV=1 CANONICAL=Q32L76-1" }, "locus": { "chromosome": "29", "start_pos": 26482347, "end_pos": 26474369, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075586.1" } ] } }, { "isoform_ac": "A0AAA9TZT7-1", "url": "https://www.uniprot.org/uniprotkb/Q32L76/entry#A0AAA9TZT7-1", "sequence": { "sequence": "MCGRRIEQEGHHQCTLDLRPLCPLIPKSGEIPTTEFQLEKGHSTMKLLIGILFCTLIMGVTGDSWYSFFKEAVQGASDLWRAYWDMRDANVQNSGRYFRARGNYEAAQRGPGGVWAAKIISNVGEYLQGFLYQIYLGDSYGLEDQVSNRRAEEWGRSGQDPDHFRPAGLPKKY", "length": 173, "header": "tr|A0AAA9TZT7-1|A0AAA9TZT7_BOVIN Computationally mapped isoform of Serum amyloid A protein OS=Bos taurus OX=9913 GN=SAA4 PE=3 SV=1 CANONICAL=Q32L76-1" }, "locus": { "chromosome": "29", "start_pos": 26482347, "end_pos": 26466352, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104684.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104684.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103101.1" } ] } }, { "isoform_ac": "Q32L76-1", "url": "https://www.uniprot.org/uniprotkb/Q32L76/entry#Q32L76-1", "sequence": { "sequence": "MKLLIGILFCTLIMGVTGDSWYSFFKEAVQGASDLWRAYWDMRDANVQNSGRYFRARGNYEAAQRGPGGVWAAKIISNVGEYLQGFLYQIYLGDSYGLEDQVSNRRAEEWGRSGQDPDHFRPAGLPKKY", "length": 129, "header": "sp|Q32L76-1|SAA4_BOVIN Isoform 1 of Serum amyloid A-4 protein OS=Bos taurus OX=9913 GN=SAA4 PE=2 SV=1 CANONICAL=Q32L76-1" }, "locus": { "chromosome": "29", "start_pos": 26482347, "end_pos": 26474930, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003858.4", "url": "https://www.ensembl.org/id/ENSBTAT00000003858.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003858.2", "url": "https://www.ensembl.org/id/ENSBTAP00000003858.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505308", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505308", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P31532-1", "protein_name": "Serum amyloid A-4 protein", "gene_name": "Saa4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLATVIVLCSLFLGVSGDGWYSFFREAVQGTWDLWRAYRDNLEANYQNADQYFYARGNYEAQQRGSGGIWAAKIISTSRKYFQGLLNRYYFGIRNHGLETLQATQKAEEWGRSGKNPNHFRPEGLPEKF", "length": 130 }, "evidence": [ { "id": "Q32L76", "url": "https://omabrowser.org/oma/group/Q32L76/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35542-1", "protein_name": "Serum amyloid A-4 protein", "gene_name": "SAA4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLFTGIVFCSLVMGVTSESWRSFFKEALQGVGDMGRAYWDIMISNHQNSNRYLYARGNYDAAQRGPGGVWAAKLISRSRVYLQGLIDCYLFGNSSTVLEDSKSNEKAEEWGRSGKDPDRFRPDGLPKKY", "length": 130 }, "evidence": [ { "id": "Q32L76", "url": "https://omabrowser.org/oma/group/Q32L76/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "high-density lipoprotein particle", "id": "GO:0034364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034364", "evidence": [ { "database": "UniProtKB", "id": "Q32L76", "url": "https://www.uniprot.org/uniprotkb/Q32L76" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "Q32L76", "url": "https://www.uniprot.org/uniprotkb/Q32L76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L76-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 129, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L76" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L78-1", "uniprot_ac": "Q32L78", "uniprot_id": "TPC6B_BOVIN", "mass": { "chemical_mass": 17983.0, "monoisotopic_mass": 17983.0 }, "refseq": { "ac": "NP_001033223", "name": "trafficking protein particle complex subunit 6B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223" }, "gene_names": [ { "name": "TRAPPC6B", "type": "recommended", "evidence": [ { "id": "Q32L78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ] }, { "name": "TRAPPC6B", "type": "synonym", "evidence": [ { "id": "NP_001033223", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 6B", "type": "recommended", "evidence": [ { "id": "Q32L78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L78/entry#names_and_taxonomy" } ] }, { "name": "TRAPP complex subunit 6B", "type": "synonym", "evidence": [ { "id": "NP_001033223", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223" }, { "id": "Q32L78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L78/entry#names_and_taxonomy" } ] }, { "name": "trafficking protein particle complex 6B", "type": "synonym", "evidence": [ { "id": "NP_001033223", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223" } ] }, { "name": "trafficking protein particle complex subunit 6B", "type": "synonym", "evidence": [ { "id": "NP_001033223", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223" } ] } ], "function": [ { "annotation": "Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78#function" }, { "database": "UniProtKB", "id": "Q86SZ2", "url": "https://www.uniprot.org/uniprotkb/Q86SZ2#function" }, { "database": "UniProtKB", "id": "A0AAA9RXM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM3#function" }, { "database": "UniProtKB", "id": "ARBA00057720", "url": "https://www.uniprot.org/uniprotkb/ARBA00057720#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC6B", "url": "https://www.uniprot.org/uniprotkb/Q32L78", "locus": { "chromosome": "21", "start_pos": 49129956, "end_pos": 49156067, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015023", "url": "https://www.ensembl.org/id/ENSBTAG00000015023" } ] } } ], "crossref": [ { "id": "Q32L78", "url": "https://alphafold.ebi.ac.uk/entry/Q32L78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015023", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015023", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14944", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14944", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521470", "url": "https://www.ncbi.nlm.nih.gov/gene/521470", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521470", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521470", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKEFWTA", "url": "https://omabrowser.org/oma/group/CKEFWTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L78", "url": "https://www.orthodb.org/?gene=Q32L78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033223", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L78-1", "url": "https://www.uniprot.org/uniprotkb/Q32L78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158, "header": "sp|Q32L78-1|TPC6B_BOVIN Isoform 1 of Trafficking protein particle complex subunit 6B OS=Bos taurus OX=9913 GN=TRAPPC6B PE=2 SV=1 CANONICAL=Q32L78-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXM3-1", "url": "https://www.uniprot.org/uniprotkb/Q32L78/entry#A0AAA9RXM3-1", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPA", "length": 148, "header": "tr|A0AAA9RXM3-1|A0AAA9RXM3_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 6B OS=Bos taurus OX=9913 GN=TRAPPC6B PE=3 SV=1 CANONICAL=Q32L78-1" }, "locus": { "chromosome": "21", "start_pos": 49155922, "end_pos": 49147019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129831.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129831.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078266.1" } ] } }, { "isoform_ac": "Q32L78-1", "url": "https://www.uniprot.org/uniprotkb/Q32L78/entry#Q32L78-1", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158, "header": "sp|Q32L78-1|TPC6B_BOVIN Isoform 1 of Trafficking protein particle complex subunit 6B OS=Bos taurus OX=9913 GN=TRAPPC6B PE=2 SV=1 CANONICAL=Q32L78-1" }, "locus": { "chromosome": "21", "start_pos": 49155922, "end_pos": 49146156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019999.4", "url": "https://www.ensembl.org/id/ENSBTAT00000019999.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019999.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019999.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521470", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521470", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SV82-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "TRAPPC6B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 130 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MCS4-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trappc6b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQLSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZES2-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trappc6b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLIQLSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C3X0-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "TRAPPC6A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADEALFLLLHNEMVAGLYRAAEQGEGENGRCTTKLESMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHAPKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKM", "length": 158 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q86SZ2-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "TRAPPC6B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CAW4-1", "protein_name": "Transport protein particle (TRAPP) component", "gene_name": "TRAPPC6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGREVAESCVDTMLMEMVAMYSGRFYANKPELAARRIEAIGYQVGHQLSERYTMERPRFSDHLEAIKFICKDFWSEVFKKQIDNLKTNHRGTFVLQDNKFRWLSRVSIDPSSENETQDPSTPGESKAAQAVSMYLYFPCGIIRGVLSNLGIPCAVSADISSLPTCSFVIRVKA", "length": 173 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9D289-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trappc6b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADEALFLLLHNEMVSGVYKSAEQGEVENGRCVTKLESMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLIQLSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL", "length": 158 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VF82-1", "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trs33", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSEEILFDCLHAEIVNYCLDSNKEHDLATLEYIGFTTGYRLIERLTREVSRFKDELETMKFICTDFWMLIYKKQVDNLRTNNHGMYVVQDKAFRFLTRISPGTKQLEHAPKFVAFTCGLVRGALSNLGINSTVTAEVQSIPACKFHIEVNRN", "length": 152 }, "evidence": [ { "id": "Q32L78", "url": "https://omabrowser.org/oma/group/Q32L78/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" }, { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "Q32L78", "url": "https://www.uniprot.org/uniprotkb/Q32L78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 158, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L78" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2S6-1", "uniprot_ac": "Q2M2S6", "uniprot_id": "HPIP_BOVIN", "mass": { "chemical_mass": 13216.0, "monoisotopic_mass": 13216.0 }, "refseq": { "ac": "NP_001039863", "name": "host cell factor C1 regulator 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863" }, "gene_names": [ { "name": "HCFC1R1", "type": "recommended", "evidence": [ { "id": "Q2M2S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ] }, { "name": "HCFC1R1", "type": "synonym", "evidence": [ { "id": "NP_001039863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863" } ] }, { "name": "HPIP", "type": "synonym", "evidence": [ { "id": "Q2M2S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ] } ], "protein_names": [ { "name": "Host cell factor C1 regulator 1", "type": "recommended", "evidence": [ { "id": "Q2M2S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#names_and_taxonomy" } ] }, { "name": "HCF-1 beta-propeller-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001039863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863" }, { "id": "Q2M2S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#names_and_taxonomy" } ] }, { "name": "host cell factor C1 regulator 1 (XPO1 dependent)", "type": "synonym", "evidence": [ { "id": "NP_001039863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863" } ] }, { "name": "host cell factor C1 regulator 1", "type": "synonym", "evidence": [ { "id": "NP_001039863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863" } ] } ], "function": [ { "annotation": "Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2S6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HCFC1R1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6", "locus": { "chromosome": "25", "start_pos": 2439925, "end_pos": 2441830, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002367", "url": "https://www.ensembl.org/id/ENSBTAG00000002367" } ] } } ], "crossref": [ { "id": "Q2M2S6", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2S6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002367", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535210", "url": "https://www.ncbi.nlm.nih.gov/gene/535210", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535210", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535210", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDNMATH", "url": "https://omabrowser.org/oma/group/EDNMATH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2M2S6", "url": "https://www.orthodb.org/?gene=Q2M2S6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16246:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16246:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039863", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7K2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7K2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7K2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2S6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2S6-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILQQPLERGPQGRAQRDPRAASGASGGLDAREPLRKQFLSEENMATHFSRLSLHNDHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDTPTPHYPASPAGDMMEL", "length": 119, "header": "sp|Q2M2S6-1|HPIP_BOVIN Isoform 1 of Host cell factor C1 regulator 1 OS=Bos taurus OX=9913 GN=HCFC1R1 PE=3 SV=1 CANONICAL=Q2M2S6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXV1-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#A0AAA9RXV1-1", "sequence": { "sequence": "MILQQPLERGPQGRAQRDPRAASGASGGLDARLPSESQPSCLPSLPREPLRKQFLSEENMATHFSRLSLHNDHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDTPTPHYPASPAGDMMEL", "length": 134, "header": "tr|A0AAA9RXV1-1|A0AAA9RXV1_BOVIN Computationally mapped isoform of Host cell factor C1 regulator 1 OS=Bos taurus OX=9913 GN=HCFC1R1 PE=4 SV=1 CANONICAL=Q2M2S6-1" }, "locus": { "chromosome": "25", "start_pos": 2441231, "end_pos": 2440163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102728.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102728.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077402.1" } ] } }, { "isoform_ac": "A0AAA9SL56-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#A0AAA9SL56-1", "sequence": { "sequence": "MILQQPLERGPQGRAQRDPRAASGASGGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSRLSLHNDHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDTPTPHYPASPAGDMMEL", "length": 138, "header": "tr|A0AAA9SL56-1|A0AAA9SL56_BOVIN Computationally mapped isoform of Host cell factor C1 regulator 1 OS=Bos taurus OX=9913 GN=HCFC1R1 PE=4 SV=1 CANONICAL=Q2M2S6-1" }, "locus": { "chromosome": "25", "start_pos": 2441231, "end_pos": 2440163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084626.1" } ] } }, { "isoform_ac": "A0ABI0P7K2-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#A0ABI0P7K2-1", "sequence": { "sequence": "PRGTACCAARSIKRTKSPRVLRPQRSLTSPEVPVGASPSRFLTYPILLAGRREDGHRVTQVPGAEVTTEKTPQHQVAPTATPLRRVPSPTPLSRPAFQLRAVLLPRLRGTWPRARLKPRPTRWVTPSKAPPLPPGSHPSVRRTPNPNDPAATPGARPPGSGPARPAGRLGGFWRPGREVCVGVGGPGWARPRVPGVLAGASSSSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSRLSLHNDHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDTPTPHYPASPAGDMMEL", "length": 309, "header": "tr|A0ABI0P7K2-1|A0ABI0P7K2_BOVIN Computationally mapped isoform of Host cell factor C1 regulator 1 OS=Bos taurus OX=9913 GN=HCFC1R1 PE=4 SV=1 CANONICAL=Q2M2S6-1" }, "locus": { "chromosome": "25", "start_pos": 2441670, "end_pos": 2440163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154224.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154224.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107704.1" } ] } }, { "isoform_ac": "Q2M2S6-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6/entry#Q2M2S6-1", "sequence": { "sequence": "MILQQPLERGPQGRAQRDPRAASGASGGLDAREPLRKQFLSEENMATHFSRLSLHNDHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDTPTPHYPASPAGDMMEL", "length": 119, "header": "sp|Q2M2S6-1|HPIP_BOVIN Isoform 1 of Host cell factor C1 regulator 1 OS=Bos taurus OX=9913 GN=HCFC1R1 PE=3 SV=1 CANONICAL=Q2M2S6-1" }, "locus": { "chromosome": "25", "start_pos": 2441231, "end_pos": 2440163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031534.3", "url": "https://www.ensembl.org/id/ENSBTAT00000031534.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031487.2", "url": "https://www.ensembl.org/id/ENSBTAP00000031487.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535210", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535210", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I022-1", "protein_name": "Host cell factor C1 regulator 1 isoform X2", "gene_name": "Hcfc1r1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MILQQPLERGPPNRDPRATTGVTRGLDAREPLHKQFLSEENMATHFSRLSLHNDHPYCSPPVTFPQALPPLRSPCPELLLWRYPGSLIPEALRLLRLGDTPSPYYPASPAGDIMEL", "length": 116 }, "evidence": [ { "id": "Q2M2S6", "url": "https://omabrowser.org/oma/group/Q2M2S6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LFV5-1", "protein_name": "Host cell factor C1 regulator 1", "gene_name": "HCFC1R1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MILQQPLERGPQGRAQRDPRATSGVPRGLDASSPLRGAVPMSTKRRLEAEQEPLRKQFLSEENMATHFSQLSLHNDHPYCSPPMALSPALPPLRTSCPELLLWRYPGNLIPEALRLLRRGDTPTPHSPATSAVDIMEL", "length": 138 }, "evidence": [ { "id": "Q2M2S6", "url": "https://omabrowser.org/oma/group/Q2M2S6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80V38-1", "protein_name": "Host cell factor C1 regulator 1", "gene_name": "Hcfc1r1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILQQPLERGPPGRDPRATTGVTLGLDTREPLHKHFLSEENMATHFSRLSLHNDHPYCSPPVTFPEALPPLRSPCPELLLWRYPGSLIPEALRLLRLGDNPSPYYSASPAGEIMEL", "length": 116 }, "evidence": [ { "id": "Q2M2S6", "url": "https://omabrowser.org/oma/group/Q2M2S6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CYQ5-1", "protein_name": "Host cell factor C1 regulator 1", "gene_name": "Hcfc1r1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILQQPLERGPPSRDPRATTGVTRGLNASLSPREPLHKQFLSEENMATHFSRLSLHNDHPYCSPPVTFPEALPPLRSPCPELLLWRYPGSLIPEALRLLRLGDTPSPYYPASPAGDIVEL", "length": 120 }, "evidence": [ { "id": "Q2M2S6", "url": "https://omabrowser.org/oma/group/Q2M2S6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWW0-1", "protein_name": "Host cell factor C1 regulator 1", "gene_name": "HCFC1R1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCSPPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGDIMEL", "length": 138 }, "evidence": [ { "id": "Q2M2S6", "url": "https://omabrowser.org/oma/group/Q2M2S6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2S6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 119, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2S6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2S6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2M2S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear export signal", "eco_id": "ECO_0000250", "start_pos": 91, "end_pos": 100, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZR9-1", "uniprot_ac": "Q3SZR9", "uniprot_id": "TSN3_BOVIN", "mass": { "chemical_mass": 27938.0, "monoisotopic_mass": 27938.0 }, "refseq": { "ac": "NP_001030564", "name": "tetraspanin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030564" }, "gene_names": [ { "name": "TSPAN3", "type": "recommended", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9" } ] }, { "name": "TSPAN3", "type": "synonym", "evidence": [ { "id": "NP_001030564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030564" } ] } ], "protein_names": [ { "name": "Tetraspanin-3", "type": "recommended", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#names_and_taxonomy" } ] }, { "name": "Tspan-3", "type": "synonym", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-3", "type": "synonym", "evidence": [ { "id": "NP_001030564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030564" } ] }, { "name": "tspan-3", "type": "synonym", "evidence": [ { "id": "NP_001030564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030564" } ] } ], "function": [ { "annotation": "Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR9", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9#function" }, { "database": "UniProtKB", "id": "A0AAA9RY67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY67#function" }, { "database": "UniProtKB", "id": "ARBA00055382", "url": "https://www.uniprot.org/uniprotkb/ARBA00055382#function" }, { "database": "UniProtKB", "id": "A0AAA9SFC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC1#function" }, { "database": "UniProtKB", "id": "A0AAA9T830", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T830#function" }, { "database": "UniProtKB", "id": "A0AAA9T904", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T904#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZR9", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9", "locus": { "chromosome": "21", "start_pos": 32177531, "end_pos": 32204399, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002415", "url": "https://www.ensembl.org/id/ENSBTAG00000002415" } ] } } ], "crossref": [ { "id": "Q3SZR9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002415", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002415", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616881", "url": "https://www.ncbi.nlm.nih.gov/gene/616881", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3SZR9", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3SZR9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616881", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616881", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ISCCKIA", "url": "https://omabrowser.org/oma/group/ISCCKIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZR9", "url": "https://www.orthodb.org/?gene=Q3SZR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030564", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T830", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T830", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T830-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T830-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T904", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T904", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T904-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T904-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR9", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 253, "header": "sp|Q3SZR9-1|TSN3_BOVIN Isoform 1 of Tetraspanin-3 OS=Bos taurus OX=9913 GN=TSPAN3 PE=2 SV=1 CANONICAL=Q3SZR9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY67-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#A0AAA9RY67-1", "sequence": { "sequence": "MGQCGITSSKTVLVFLNLIFWVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 164, "header": "tr|A0AAA9RY67-1|A0AAA9RY67_BOVIN Computationally mapped isoform of Tetraspanin-3 OS=Bos taurus OX=9913 GN=TSPAN3 PE=3 SV=1 CANONICAL=Q3SZR9-1" }, "locus": { "chromosome": "21", "start_pos": 32204278, "end_pos": 32178348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102789.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102789.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074759.1" } ] } }, { "isoform_ac": "A0AAA9SFC1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#A0AAA9SFC1-1", "sequence": { "sequence": "WDIEGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 236, "header": "tr|A0AAA9SFC1-1|A0AAA9SFC1_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN3 PE=3 SV=1 CANONICAL=Q3SZR9-1" }, "locus": { "chromosome": "21", "start_pos": 32192701, "end_pos": 32178348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121224.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121224.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082555.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082555.1" } ] } }, { "isoform_ac": "A0AAA9T830-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#A0AAA9T830-1", "sequence": { "sequence": "MGQCGITSSKTVLVFLNLIFWFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 189, "header": "tr|A0AAA9T830-1|A0AAA9T830_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN3 PE=3 SV=1 CANONICAL=Q3SZR9-1" }, "locus": { "chromosome": "21", "start_pos": 32204278, "end_pos": 32178348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135287.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135287.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094115.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094115.1" } ] } }, { "isoform_ac": "A0AAA9T904-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#A0AAA9T904-1", "sequence": { "sequence": "MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 228, "header": "tr|A0AAA9T904-1|A0AAA9T904_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN3 PE=3 SV=1 CANONICAL=Q3SZR9-1" }, "locus": { "chromosome": "21", "start_pos": 32204278, "end_pos": 32178348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115332.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115332.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093320.1" } ] } }, { "isoform_ac": "Q3SZR9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9/entry#Q3SZR9-1", "sequence": { "sequence": "MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASSCNGSLANPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGAYA", "length": 253, "header": "sp|Q3SZR9-1|TSN3_BOVIN Isoform 1 of Tetraspanin-3 OS=Bos taurus OX=9913 GN=TSPAN3 PE=2 SV=1 CANONICAL=Q3SZR9-1" }, "locus": { "chromosome": "21", "start_pos": 32204278, "end_pos": 32178348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003131.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003131.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003131.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003131.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 127, "start_aa": "Asn", "end_pos": 127, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn127", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 152, "start_aa": "Asn", "end_pos": 152, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn152", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 183, "start_aa": "Asn", "end_pos": 183, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn183", "evidence": [ { "id": "Q3SZR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616881", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616881", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR9", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR9", "url": "https://www.uniprot.org/uniprotkb/Q3SZR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZR9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 253, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZR9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZR9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 127, 152, 167, 183 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 152, "end_pos": 154 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 183, "end_pos": 185 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SWY4-1", "uniprot_ac": "Q3SWY4", "uniprot_id": "LRN4L_BOVIN", "mass": { "chemical_mass": 24410.0, "monoisotopic_mass": 24410.0 }, "refseq": { "ac": "NP_001181998", "name": "LRRN4 C-terminal-like protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181998" }, "gene_names": [ { "name": "LRRN4CL", "type": "recommended", "evidence": [ { "id": "Q3SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4" } ] }, { "name": "LRRN4CL", "type": "synonym", "evidence": [ { "id": "NP_001181998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181998" } ] } ], "protein_names": [ { "name": "LRRN4 C-terminal-like protein", "type": "recommended", "evidence": [ { "id": "Q3SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4/entry#names_and_taxonomy" } ] }, { "name": "LRRN4 C-terminal-like protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001181998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181998" } ] }, { "name": "LRRN4 C-terminal-like protein", "type": "synonym", "evidence": [ { "id": "NP_001181998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181998" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWY4", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRN4CL", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4", "locus": { "chromosome": "29", "start_pos": 41013142, "end_pos": 41014994, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010484", "url": "https://www.ensembl.org/id/ENSBTAG00000010484" } ] } } ], "crossref": [ { "id": "Q3SWY4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010484", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010484", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788567", "url": "https://www.ncbi.nlm.nih.gov/gene/788567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788567", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788567", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCSALVW", "url": "https://omabrowser.org/oma/group/SCSALVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SWY4", "url": "https://www.orthodb.org/?gene=Q3SWY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWY4", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWY4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPHSPCLLWLLAVTSLVPGTQPLVAGDLEGDELDETPLPAVPCDYDHCRHLQVPCQELQRAGPAACLCPGLSSALQPPHPPRLGEVRVEADMGRAEVHWCAPSSPVNQYWLLLWEGGGAPQKGPSFNSTVRRAELKGLNPGGAYVVCVVAANDAGESRAPGPGAEGLDSADGPNLGPCGRLTVPPRPLTLLHAAMGVGSALALLSCSALVWHFCLRQRWGCPRRGRPSHAGL", "length": 232, "header": "sp|Q3SWY4-1|LRN4L_BOVIN Isoform 1 of LRRN4 C-terminal-like protein OS=Bos taurus OX=9913 GN=LRRN4CL PE=2 SV=2 CANONICAL=Q3SWY4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1C6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4/entry#A0AAA9S1C6-1", "sequence": { "sequence": "MDSMPHSPCLLWLLAVTSLVPGTQPLVAGDLEGDELDETPLPAVPCDYDHCRHLQVPCQELQRAGPAACLCPGLSSALQPPHPPRLGEVRVEADMGRAEVHWCAPSSPVNQYWLLLWEGGGAPQKGPSFNSTVRRAELKGLNPGGAYVVCVVAANDAGESRAPGPGAEGLDSADGPNLGPCGRLTVPPRPLTLLHAAMGVGSALALLSCSALVWHFCLRQRWGCPRRGRPSHAGL", "length": 235, "header": "tr|A0AAA9S1C6-1|A0AAA9S1C6_BOVIN Computationally mapped isoform of LRRN4 C-terminal like OS=Bos taurus OX=9913 GN=LRRN4CL PE=4 SV=1 CANONICAL=Q3SWY4-1" }, "locus": { "chromosome": "29", "start_pos": 41014795, "end_pos": 41013949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130458.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130458.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075889.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075889.1" } ] } }, { "isoform_ac": "Q3SWY4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4/entry#Q3SWY4-1", "sequence": { "sequence": "MPHSPCLLWLLAVTSLVPGTQPLVAGDLEGDELDETPLPAVPCDYDHCRHLQVPCQELQRAGPAACLCPGLSSALQPPHPPRLGEVRVEADMGRAEVHWCAPSSPVNQYWLLLWEGGGAPQKGPSFNSTVRRAELKGLNPGGAYVVCVVAANDAGESRAPGPGAEGLDSADGPNLGPCGRLTVPPRPLTLLHAAMGVGSALALLSCSALVWHFCLRQRWGCPRRGRPSHAGL", "length": 232, "header": "sp|Q3SWY4-1|LRN4L_BOVIN Isoform 1 of LRRN4 C-terminal-like protein OS=Bos taurus OX=9913 GN=LRRN4CL PE=2 SV=2 CANONICAL=Q3SWY4-1" }, "locus": { "chromosome": "29", "start_pos": 41014644, "end_pos": 41013949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013854.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013854.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013854.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013854.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 127, "start_aa": "Asn", "end_pos": 127, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn127", "evidence": [ { "id": "Q3SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:788567", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788567", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TYX2-1", "protein_name": "LRRN4 C-terminal-like protein", "gene_name": "Lrrn4cl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGSLSLLWLAAMTTSLVSQPQILTLEDYQEGEEDDVTVATPSLAVRCDYDRCRHLQVSCQELQKVGPVACLCPGLSREDQQPEPPRLGEVQIMAEEGYAVVHWCAPFSPVSHYWLLLWESNGAPQKSAPLNATVRRAELKGLKPGVAYVLCVVAANDAGESNVPGAEVEGPENWTGPSFGPCRKFIMPPKPVTLVYAAVGVGTALALLSCAALVWHFCLRERWGCPRRQGMAQASEAL", "length": 239 }, "evidence": [ { "id": "Q3SWY4", "url": "https://omabrowser.org/oma/group/Q3SWY4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8ND94-1", "protein_name": "LRRN4 C-terminal-like protein", "gene_name": "LRRN4CL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGSPCLLWLLAVTFLVPRAQPLAPQDFEEEEADETETAWPPLPAVPCDYDHCRHLQVPCKELQRVGPAACLCPGLSSPAQPPDPPRMGEVRIAAEEGRAVVHWCAPFSPVLHYWLLLWDGSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANEAGASRVPQAGGEGLEGADIPAFGPCSRLAVPPNPRTLVHAAVGVGTALALLSCAALVWHFCLRDRWGCPRRAAARAAGAL", "length": 238 }, "evidence": [ { "id": "Q3SWY4", "url": "https://omabrowser.org/oma/group/Q3SWY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY4", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWY4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 232, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWY4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWY4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY4" }, { "id": "PRU00316", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00316" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000255", "start_pos": 77, "end_pos": 172, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "Asn127" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 127 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9A7-1", "uniprot_ac": "Q5E9A7", "uniprot_id": "KLDC2_BOVIN", "mass": { "chemical_mass": 46125.0, "monoisotopic_mass": 46125.0 }, "refseq": { "ac": "NP_001014948", "name": "kelch domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014948" }, "gene_names": [ { "name": "KLHDC2", "type": "recommended", "evidence": [ { "id": "Q5E9A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ] }, { "name": "KLHDC2", "type": "synonym", "evidence": [ { "id": "NP_001014948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014948" } ] } ], "protein_names": [ { "name": "Kelch domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q5E9A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7/entry#names_and_taxonomy" } ] }, { "name": "kelch domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001014948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014948" } ] } ], "function": [ { "annotation": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (By similarity). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (By similarity). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7#function" }, { "database": "UniProtKB", "id": "Q9Y2U9", "url": "https://www.uniprot.org/uniprotkb/Q9Y2U9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHDC2", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7", "locus": { "chromosome": "10", "start_pos": 42764720, "end_pos": 42749340, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004933", "url": "https://www.ensembl.org/id/ENSBTAG00000004933" } ] } } ], "crossref": [ { "id": "Q5E9A7", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9A7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004933", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004933", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535436", "url": "https://www.ncbi.nlm.nih.gov/gene/535436", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535436", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535436", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MGKLLQF", "url": "https://omabrowser.org/oma/group/MGKLLQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9A7", "url": "https://www.orthodb.org/?gene=Q5E9A7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46228:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014948", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADGYEDLREDELPGPAYEGYESAELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLHWERIDCQGVPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFIWSQPITTGKPPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIKFNHPHTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS", "length": 406, "header": "sp|Q5E9A7-1|KLDC2_BOVIN Isoform 1 of Kelch domain-containing protein 2 OS=Bos taurus OX=9913 GN=KLHDC2 PE=2 SV=1 CANONICAL=Q5E9A7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2Y3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7/entry#A0AAA9S2Y3-1", "sequence": { "sequence": "MADGYEDLREDELPGPAYEGYESAELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLHWERIDCQGVPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFIWSQPITTGKPPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIKFNHPHTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAKFRSCHLL", "length": 357, "header": "tr|A0AAA9S2Y3-1|A0AAA9S2Y3_BOVIN Computationally mapped isoform of Kelch domain containing 2 OS=Bos taurus OX=9913 GN=KLHDC2 PE=4 SV=1 CANONICAL=Q5E9A7-1" }, "locus": { "chromosome": "10", "start_pos": 42764441, "end_pos": 42749632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111151.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111151.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080281.1" } ] } }, { "isoform_ac": "A0AAA9TVJ1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7/entry#A0AAA9TVJ1-1", "sequence": { "sequence": "MADGYEDLREDELPGPAYEGYESAELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLHWERIDCQGVPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFIWSQPITTGKPPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLNYGIQLVPVMKEK", "length": 307, "header": "tr|A0AAA9TVJ1-1|A0AAA9TVJ1_BOVIN Computationally mapped isoform of Kelch domain containing 2 OS=Bos taurus OX=9913 GN=KLHDC2 PE=4 SV=1 CANONICAL=Q5E9A7-1" }, "locus": { "chromosome": "10", "start_pos": 42763995, "end_pos": 42749632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100394.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100394.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102378.1" } ] } }, { "isoform_ac": "Q5E9A7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7/entry#Q5E9A7-1", "sequence": { "sequence": "MADGYEDLREDELPGPAYEGYESAELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLHWERIDCQGVPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFIWSQPITTGKPPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIKFNHPHTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS", "length": 406, "header": "sp|Q5E9A7-1|KLDC2_BOVIN Isoform 1 of Kelch domain-containing protein 2 OS=Bos taurus OX=9913 GN=KLHDC2 PE=2 SV=1 CANONICAL=Q5E9A7-1" }, "locus": { "chromosome": "10", "start_pos": 42764535, "end_pos": 42749632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006490.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006490.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006490.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006490.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535436", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535436", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3KRE6-1", "protein_name": "Kelch domain-containing protein 2", "gene_name": "Klhdc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADGNEDARAEDMPGPAFEGYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS", "length": 406 }, "evidence": [ { "id": "Q5E9A7", "url": "https://omabrowser.org/oma/group/Q5E9A7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4G5Y1-1", "protein_name": "Kelch domain-containing protein 2", "gene_name": "Klhdc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADGNEDARAEDLPGPAFENYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRGLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS", "length": 406 }, "evidence": [ { "id": "Q5E9A7", "url": "https://omabrowser.org/oma/group/Q5E9A7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2U9-1", "protein_name": "Kelch domain-containing protein 2", "gene_name": "KLHDC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS", "length": 406 }, "evidence": [ { "id": "Q5E9A7", "url": "https://omabrowser.org/oma/group/Q5E9A7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "id": "GO:0140627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140627", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A7", "url": "https://www.uniprot.org/uniprotkb/Q5E9A7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9A7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 406, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9A7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9A7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 402, "end_pos": 404 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHM8-1", "uniprot_ac": "Q3MHM8", "uniprot_id": "AR6P6_BOVIN", "mass": { "chemical_mass": 24657.0, "monoisotopic_mass": 24657.0 }, "refseq": { "ac": "NP_001029453", "name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" }, "gene_names": [ { "name": "ARL6IP6", "type": "recommended", "evidence": [ { "id": "Q3MHM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ] }, { "name": "ARL6IP6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "type": "recommended", "evidence": [ { "id": "Q3MHM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like 6 interacting protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" } ] }, { "name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" } ] }, { "name": "ADP-ribosylation-like factor 6 interacting protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" } ] }, { "name": "ARL-6-interacting protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" }, { "id": "Q3MHM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#names_and_taxonomy" } ] }, { "name": "Aip-6", "type": "synonym", "evidence": [ { "id": "Q3MHM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#names_and_taxonomy" } ] }, { "name": "aip-6", "type": "synonym", "evidence": [ { "id": "NP_001029453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL6IP6", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8", "locus": { "chromosome": "2", "start_pos": 43427948, "end_pos": 43469180, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001435", "url": "https://www.ensembl.org/id/ENSBTAG00000001435" } ] } } ], "crossref": [ { "id": "Q3MHM8", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001435", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001435", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507137", "url": "https://www.ncbi.nlm.nih.gov/gene/507137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507137", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507137", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVAWCLL", "url": "https://omabrowser.org/oma/group/TVAWCLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHM8", "url": "https://www.orthodb.org/?gene=Q3MHM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28640:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28640:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029453", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHM8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKELHAENLKNEDDVNTGLLGFWSLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKMTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 226, "header": "sp|Q3MHM8-1|AR6P6_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 6-interacting protein 6 OS=Bos taurus OX=9913 GN=ARL6IP6 PE=2 SV=1 CANONICAL=Q3MHM8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3S5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#A0AAA9S3S5-1", "sequence": { "sequence": "MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKELHAENLKNEDDVNTGLLGK", "length": 153, "header": "tr|A0AAA9S3S5-1|A0AAA9S3S5_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 6 interacting protein 6 OS=Bos taurus OX=9913 GN=ARL6IP6 PE=4 SV=1 CANONICAL=Q3MHM8-1" }, "locus": { "chromosome": "2", "start_pos": 43469169, "end_pos": 43429375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133448.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133448.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080588.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080588.1" } ] } }, { "isoform_ac": "A0AAA9T1A0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#A0AAA9T1A0-1", "sequence": { "sequence": "MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKGFWSLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKMTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 208, "header": "tr|A0AAA9T1A0-1|A0AAA9T1A0_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 6 interacting protein 6 OS=Bos taurus OX=9913 GN=ARL6IP6 PE=4 SV=1 CANONICAL=Q3MHM8-1" }, "locus": { "chromosome": "2", "start_pos": 43469169, "end_pos": 43429289, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114870.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114870.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091471.1" } ] } }, { "isoform_ac": "A0AAA9TWU6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#A0AAA9TWU6-1", "sequence": { "sequence": "MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKELHAENLKNEDDVNTGLLGFWSLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKDCLEPSVVKLSLLMNILMALHRGFLKG", "length": 223, "header": "tr|A0AAA9TWU6-1|A0AAA9TWU6_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 6 interacting protein 6 OS=Bos taurus OX=9913 GN=ARL6IP6 PE=4 SV=1 CANONICAL=Q3MHM8-1" }, "locus": { "chromosome": "2", "start_pos": 43469169, "end_pos": 43443435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102831.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102831.1" } ] } }, { "isoform_ac": "Q3MHM8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8/entry#Q3MHM8-1", "sequence": { "sequence": "MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKELHAENLKNEDDVNTGLLGFWSLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKMTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 226, "header": "sp|Q3MHM8-1|AR6P6_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 6-interacting protein 6 OS=Bos taurus OX=9913 GN=ARL6IP6 PE=2 SV=1 CANONICAL=Q3MHM8-1" }, "locus": { "chromosome": "2", "start_pos": 43469169, "end_pos": 43429289, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001883.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001883.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001883.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001883.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "site_lbl": "Ser2" }, { "start_pos": 36, "end_pos": 36, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "site_lbl": "Ser36" }, { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "site_lbl": "Ser60" }, { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "site_lbl": "Ser65" }, { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "site_lbl": "Ser80" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507137", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507137", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VSF7-1", "protein_name": "ADP ribosylation factor like GTPase 6 interacting protein 6", "gene_name": "ARL6IP6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSFVESGRRPAPLRRRPGTPVPFARPAFSASTQGDSWGEGEVDEEEGCDRVARDLRAEFSARASPEPRKDSLLRPDGDGSSLLADKRNGILADAGGRTRARRWPVQVLSILCSLLFAILLAFLLAITYLIVKELHAENLKNEDDVHTGLLGFWTLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 225 }, "evidence": [ { "id": "Q3MHM8", "url": "https://omabrowser.org/oma/group/Q3MHM8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FV2-1", "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "gene_name": "Arl6ip6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFVESWRSVGPRRRRQVTPGPVTRSVYSDYTQGNSWSEDGDEGCDQVARDLRAEFSARASSESKRAPLLPRIGDGSPVLPDKRNGIFPATAAKRTQARRWPIQALSILCSLLFAVLLAFLLAIAYLIVKELHTENSKNEDVVDTGLLGFWSLLIISLTAGLSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGVVAALTVAWCLM", "length": 223 }, "evidence": [ { "id": "Q3MHM8", "url": "https://omabrowser.org/oma/group/Q3MHM8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BH07-1", "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "gene_name": "Arl6ip6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFVESWRFAGARRRRQVTPGPATRPGYSDYTQGDSWGEGEGDEDEGCDQVARDLRAEFSARASSETKRAPLLPRVGDGSPVLPDKRNGIFPATAAKRTQARRWPIQALSILCSLLFAVLLAFLLAIAYMIVKELHAENLKNEDDIHTGLLGFWSLLIISLTAGLSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 226 }, "evidence": [ { "id": "Q3MHM8", "url": "https://omabrowser.org/oma/group/Q3MHM8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N6S5-1", "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "gene_name": "ARL6IP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFAESGWRSALRRRGPGTPGPVARPSYSSFTQGDSWGEGEVDEEEGCDQVARDLRAEFSAGAWSEPRKRSVLPPDGNGSPVLPDKRNGIFPAAAGSRAQPRRWPVQVLSILCSLLFAILLAFLLAIAYLIVKELHAENLKNEDDVDTGLLGFWTLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGIVAALTVAWCLM", "length": 226 }, "evidence": [ { "id": "Q3MHM8", "url": "https://omabrowser.org/oma/group/Q3MHM8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "Q3MHM8", "url": "https://www.uniprot.org/uniprotkb/Q3MHM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHM8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHM8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHM8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2, 36, 60, 65, 80 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJF7-1", "uniprot_ac": "Q2KJF7", "uniprot_id": "GLCTK_BOVIN", "mass": { "chemical_mass": 54720.0, "monoisotopic_mass": 54720.0 }, "refseq": { "ac": "NP_001039452", "name": "glycerate kinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039452" }, "gene_names": [ { "name": "GLYCTK", "type": "recommended", "evidence": [ { "id": "Q2KJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ] }, { "name": "GLYCTK", "type": "synonym", "evidence": [ { "id": "NP_001039452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039452" } ] } ], "protein_names": [ { "name": "Glycerate kinase", "type": "recommended", "evidence": [ { "id": "Q2KJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.31", "type": "synonym", "evidence": [ { "id": "Q2KJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7/entry#names_and_taxonomy" } ] }, { "name": "glycerate kinase", "type": "synonym", "evidence": [ { "id": "NP_001039452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039452" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLYCTK", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7", "locus": { "chromosome": "22", "start_pos": 48589692, "end_pos": 48593026, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021695", "url": "https://www.ensembl.org/id/ENSBTAG00000021695" } ] } } ], "crossref": [ { "id": "Q2KJF7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507949", "url": "https://www.ncbi.nlm.nih.gov/gene/507949", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025286", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025286", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507949", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507949", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKAAWRM", "url": "https://omabrowser.org/oma/group/GKAAWRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJF7", "url": "https://www.orthodb.org/?gene=Q2KJF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12227", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12227", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12227:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12227:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13660", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13660", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70350", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70350", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039452", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23516", "url": "https://www.rhea-db.org/rhea/23516", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4E0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4E0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJF7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALQVLRHLARAPSGPLLWGGPLARMASSMALAEQARQLFESTVGAVLPGPLLQRALSLDPDSGELKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMEHAGKQEMLLKPHSRIQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASIHSVQDCLYILNRYGLRTALPRSVKTVLARADSDPHGPHTCGHVLNVILGSNALALAEAQKQAEALGYRAVVLSTAIQGDVKSVAQFYGLLARVAGAHLALPGAGASVQEDERLYELAADLQLPDLQLKEALEAVVGAPGPVCLLAGGEPTVRLQGSGKGGRNQELALRVGVELGQWPLGTVDVLFLSGGTDGQDGPTEAAGAWVRPELTSQAAAEGLDVATFLAHNDSHTFFCRFQGGAHLLHTGLTGTNVTDAHFLFLHPQ", "length": 523, "header": "sp|Q2KJF7-1|GLCTK_BOVIN Isoform 1 of Glycerate kinase OS=Bos taurus OX=9913 GN=GLYCTK PE=2 SV=1 CANONICAL=Q2KJF7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4E0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7/entry#A0AAA9S4E0-1", "sequence": { "sequence": "MAAALQVLRHLARAPSGPLLWGGPLARMASSMALAEQARQLFESTVGAVLPGPLLQRALSLDPDSGELKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMEHAGKQEMLLKPHSRIQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASIHSVQDCLYILNRYGLRTALPRSVKTVLARADSDPHGPHTCGHVLNVILGSNALALAEAQKQAEALGYRAVVLSTAIQGWGTPAAHGADWHQCHRRPLSVPASAVMM", "length": 367, "header": "tr|A0AAA9S4E0-1|A0AAA9S4E0_BOVIN Computationally mapped isoform of Glycerate kinase OS=Bos taurus OX=9913 GN=GLYCTK PE=1 SV=1 CANONICAL=Q2KJF7-1" }, "locus": { "chromosome": "22", "start_pos": 48592763, "end_pos": 48590070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091268.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091268.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076995.1" } ] } }, { "isoform_ac": "A0AAA9TP28-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7/entry#A0AAA9TP28-1", "sequence": { "sequence": "MAAALQVLRHLARAPSGPLLWGGPLARMASSMALAEQARQLFESTVGAVLPGPLLQRALSLDPDSGELKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMEHAGKQEMLLKPHSRIQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGEPHSVRRGGGPRGGDCQRPHCGQHPQRARLPVHPQSLWPSHCPATFCEDCAGPGRL", "length": 234, "header": "tr|A0AAA9TP28-1|A0AAA9TP28_BOVIN Computationally mapped isoform of Glycerate kinase OS=Bos taurus OX=9913 GN=GLYCTK PE=1 SV=1 CANONICAL=Q2KJF7-1" }, "locus": { "chromosome": "22", "start_pos": 48592763, "end_pos": 48590769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093587.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093587.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098991.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098991.1" } ] } }, { "isoform_ac": "Q2KJF7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7/entry#Q2KJF7-1", "sequence": { "sequence": "MAAALQVLRHLARAPSGPLLWGGPLARMASSMALAEQARQLFESTVGAVLPGPLLQRALSLDPDSGELKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMEHAGKQEMLLKPHSRIQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASIHSVQDCLYILNRYGLRTALPRSVKTVLARADSDPHGPHTCGHVLNVILGSNALALAEAQKQAEALGYRAVVLSTAIQGDVKSVAQFYGLLARVAGAHLALPGAGASVQEDERLYELAADLQLPDLQLKEALEAVVGAPGPVCLLAGGEPTVRLQGSGKGGRNQELALRVGVELGQWPLGTVDVLFLSGGTDGQDGPTEAAGAWVRPELTSQAAAEGLDVATFLAHNDSHTFFCRFQGGAHLLHTGLTGTNVTDAHFLFLHPQ", "length": 523, "header": "sp|Q2KJF7-1|GLCTK_BOVIN Isoform 1 of Glycerate kinase OS=Bos taurus OX=9913 GN=GLYCTK PE=2 SV=1 CANONICAL=Q2KJF7-1" }, "locus": { "chromosome": "22", "start_pos": 48592763, "end_pos": 48590078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028914.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028914.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028914.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028914.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 257, "start_aa": "Thr", "end_pos": 257, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr257", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "site_lbl": "Ser60" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507949", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507949", "resource": "KEGG Pathway" }, { "id": "R-BTA-70350", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70350", "resource": "Reactome", "description": "Fructose catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HP55-1", "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAALQVLPSLLRAPSRPFFWGPPVARMSSGMALAEQARQLFESAVGAVQPGPMLQRALSLDPSGKQLKVRDRSFQLRENLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMEHAGKQEMLLKPHSHIQVFEGAEDNLPDRDALRAALAIQQLAEGLTAEDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAAHGATIQELNTIRKTLSQLKGGGLAQAAYPAQVVSLILSDVIGDPLEVIASGPTVASAHSVQDCLQILNRYGLRAALPRSVKTVLSRADSDPRGPHTCGHVLNVIIGSNSLALAEAQKQAEVLGYRAMVLSTAIQGDVKNVAQFYGLLARVAAARLTSSTAGHPLEEEAKLHQLAAELPLPDLQLEEALEAVAKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALHVGTELGRQPLGPIDVLFLSGGTDGQDGPTKAAGAWVTSDLVSQASAEGLDIATFLSNNDSYTFFSRFQGGTHLLHTGLTGTNVMDVHLLIFRPQ", "length": 523 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A3Q2U5V7-1", "protein_name": "Glycerate kinase", "gene_name": "GLYCTK", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLCEHALSLFRSAVGTVRPAPMLKRALKLQGEGCPQLLVNSRAFPLKRGLYLVGFGKAVLGMAAAAEEILGDHLVRGIINVPLGIQESLQRAGMQEMLLKPHSRIQVIEGAKNNLPDPEALRGASAIQELAEGLTADDLLLVLISGGGSALLPAPIPPILLEEKEKLTKMLASRGAAIQELNTVRKILSLLKGGGLARLAYPAQVVSLILSDVIGDPLDIIASGPTAASSHSVQDCLQILAKYNLLHSLPGSVEAVLSSSPTKPTAAKDYSHVCNIIIGSNTLALAEAKRQAEGLGYVTLILSAGVCGDVGRVAVLYCQLICLLCLRLAGLGEGPRGSEVRGNLLQLAAELDIPGLNVAEFLQALQGLEPQKPVCILAGGETTVQLQGTGKGGRNQELALRVGLGLHRARGVEASGLGRCDVVFLSGGTDGQDGPTEAAGAFCSPELVAEALQEGLDAETFLSNNDSYTFFSQFQRGRHLLVTGLTGTNVMDIQLILIRATDRS", "length": 505 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SIX9-1", "protein_name": "Glycerate kinase", "gene_name": "GLYCTK", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAIALQVLRHFARAPSRPLLWGCPLTRLASGMALEEQARQIFESTVGAMLPGPMLQRALSLDPDSGQLKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPRGIRAAMEHAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQKLTKLLAARGANIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASVHSVQDCLHILNRYGLRAALPRSVKTVLARADSDPHGPHACGHVLNVIIGSNALALAEAQKQAEALGYKAVVLSTAIQGDVKNVAQFYGLLARVAGACLTMPAAGTSVEEDKQLYELAAQLQLPDLQLKEALEAVVGAQGPVCLLAGGEPTVQLQGSGKGGRNQELALRVGVELGQWPLEPIDVLFLSGGTDGQDGPTEAAGAWVRPELARQAVAEGLDVAAFLAHNDSYTFFCRFQGGAHLLHTGLTGTNVMDTHLLFLRPR", "length": 523 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08BL7-1", "protein_name": "Glycerate kinase", "gene_name": "glyctk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSLNTRARAVFSAAVEGVHPDMVVRRGLERHGDKLHVGGQSFTLTNNLYLVGFGKAVLGMAAEAERIVGDHLIKGVVSVPHGIQNTLRSHGKEKMLLESNSRITVMEGAKHNLPDTDAQKSAECIRDLASSLTEKDLLLVLISGGGSALLPAPAPPMSLQEKQDVTRKLAAAGATIQELNTVRRALSLLKGGGLAQCASPAKVVALILSDVIGDPLDLIASGPTVRSDSSPEEVWAILDNYKLSDSLPSSVKEVLSKSISGQGSGVKNQPQEVKDNVLNVVIGSNTIALECASRKASELGLRPVILSPGVCGDVRSVARLYGLLSSFACSPGKEPPPELAAEILKLGPEVGIESWDLCRTMNVLVGERKEGWGATCLLAGGEPTVKLSGKGRGGRNQELAMRVGLELSQGEVKSGAVFLSGGTDGQDGPTEAAGAVADGELKEEAASQGLDTDSFLANNDSFTFFSKLSEGRRLLNPGLTGTNVMDVHVMLLPPSPQKDLQ", "length": 502 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q0VGK3-1", "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAALQVLPCLLRAPSRPFLWGPPVARMTSGMALAEQARQLFDSAVGAVQPGPMLQRTLSLDPSGKQLKVRDRTFQLQENLYLVGFGKAVLGMAAAADELLGQHLVQGVISVPKGIRAAVELAGKQEMLLKPHSHIQVFEGAEDNLPDRDALRAAQAIQQLAERLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVIGDPLEVIASGPTVASTHSVQDCLHILNHYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLSTAMQGDVRRVAQFYGLLARVAAACLTSSTAERPLEEEAKLHQLAAELQLPDLQLEEALEAVAKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALRVGAELGKQPLGPVDVLFLSGGTDGQDGPTKVAGAWVMSDLVSQASAENLDFATFLDNNDSYTFFCSFQGGTHLLHTGLTGTNVMDVHLLVFHPQ", "length": 523 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IVS8-1", "protein_name": "Glycerate kinase", "gene_name": "GLYCTK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAALQVLPRLARAPLHPLLWRGSVARLASSMALAEQARQLFESAVGAVLPGPMLHRALSLDPGGRQLKVRDRNFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMERAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLSAAMQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEALETMAWGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGGTDGQDGPTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMTGTNVMDTHLLFLRPR", "length": 523 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8QZY2-1", "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAALQVLPCLLRAPSRPLLWGPPVARMTSGMALAEQARQLFDSAVGAVQPGPMLQRTLSLDPSGRQLKVRDRTFQLRENLYLVGFGKAVLGMAAAAEELLAQHLVQGVISVPKGIRAAMEHAGKKEMLLKPHSRVQVFEGAEDNLPDRDALRAALTIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVISLILSDVIGDPLEVIASGPTVASAHSVQDCLHILNHYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLSTAMQGDVKRVARFYGLLARVAAAHLTPSLAERPLEEEAELHQLAAELQLPDLQLEEALEAVAKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALHVGVELGRQPLGPIDVLFLSGGTDGQDGPTKVAGAWVMSDLISQASAESLDIATSLTNNDSYTFFCRFRGGTHLLHTGLTGTNVMDVHLLILHPQ", "length": 523 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VQC4-1", "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAKRQTWEQMRQIFVQAVNAVHPEKVFADFQKFDLRPQIGENATDISIKLNGERQDISGKTCHIVGFGKAVLGMANKVQQDLGATSAGGVLSVPVNTLKQFQQPVAPGLVVHEGAANNLPDENALKAAREIKQLAEKMTAQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMKRGASIQEINAVRIACSDIKGGRLARLAGQAGLLVTFVLSDIIGDPLELIACGPTIQPEAAASPSDILKKHHVWEELSPEIRRVFEQPEEQKNTSLPEHKVFVVGSNVIATSTAAHEAERLGYIPCVLSCAVQGDVAQVAGDYQRLLHGIQEAKQHGILDPQLREKYAFGERSYPTFRRALEDHMSSKKPLFLICGGEPVIKVSGHGLGGRSQHLALLMSQALHRDEAMRDCTFLSAGTDGIDGPTDAAGAFGDSSVVESYLGDHTLDELAETLRNCDSYNFYKNLAQGEHHVLTGHTGTNVMDLHFLVVP", "length": 487 }, "evidence": [ { "id": "Q2KJF7", "url": "https://omabrowser.org/oma/group/Q2KJF7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycerate kinase activity", "id": "GO:0008887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008887", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF7", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23516", "name": "", "equation": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJF7-1" ], "evidence": [ { "id": "23516", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23516" } ] }, { "id": "R-BTA-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-6799497" ], "output_participant_list": [ "R-ALL-6799493" ], "enzyme_list": [ "Q2KJF7-1" ], "evidence": [ { "id": "R-BTA-6799495", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799495" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6799493", "participant_name": "3PDGA [cytosol]", "crossref": [ { "id": "58272", "database": "ChEBI", "url": "" }, { "id": "ZINC000003869934", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-6799497", "participant_name": "DGA [cytosol]", "crossref": [ { "id": "16659", "database": "ChEBI", "url": "" }, { "id": "5460358", "database": "PubChem Compound", "url": "" }, { "id": "C00258", "database": "KEGG Gene", "url": "" }, { "id": "GLYCERATE", "database": "AraCyc", "url": "" }, { "id": "473-81-4", "database": "CAS", "url": "" }, { "id": "6000-40-4", "database": "CAS", "url": "" }, { "id": "ZINC000000895140", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q2KJF7", "gene_name": "GLYCTK", "activity": [ { "ec_number": "2.7.1.31", "activity": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+).", "evidence": [ { "id": "Q2KJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ] }, { "ec_number": "2.7.1.31", "activity": "", "evidence": [ { "id": "Q2KJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 523, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.31", "ec_name": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+).", "evidence": [ { "id": "2.7.1.31", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.31" }, { "id": "2.7.1.31", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.31" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 257 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 60 ], "sequon_annotation_sites": [ { "start_pos": 487, "end_pos": 489 }, { "start_pos": 511, "end_pos": 513 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZZ5-1", "uniprot_ac": "Q3SZZ5", "uniprot_id": "TM208_BOVIN", "mass": { "chemical_mass": 19592.0, "monoisotopic_mass": 19592.0 }, "refseq": { "ac": "NP_001029457", "name": "transmembrane protein 208", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029457" }, "gene_names": [ { "name": "TMEM208", "type": "recommended", "evidence": [ { "id": "Q3SZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ] }, { "name": "HSPC171", "type": "synonym", "evidence": [ { "id": "NP_001029457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029457" } ] }, { "name": "TMEM208", "type": "synonym", "evidence": [ { "id": "NP_001029457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029457" } ] } ], "protein_names": [ { "name": "Transmembrane protein 208", "type": "recommended", "evidence": [ { "id": "Q3SZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 208", "type": "synonym", "evidence": [ { "id": "NP_001029457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029457" } ] } ], "function": [ { "annotation": "May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L7#function" }, { "database": "UniProtKB", "id": "ARBA00003220", "url": "https://www.uniprot.org/uniprotkb/ARBA00003220#function" }, { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5#function" }, { "database": "UniProtKB", "id": "Q9BTX3", "url": "https://www.uniprot.org/uniprotkb/Q9BTX3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM208", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5", "locus": { "chromosome": "18", "start_pos": 34857710, "end_pos": 34855548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002327", "url": "https://www.ensembl.org/id/ENSBTAG00000002327" } ] } } ], "crossref": [ { "id": "Q3SZZ5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002327", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002327", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507222", "url": "https://www.ncbi.nlm.nih.gov/gene/507222", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507222", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507222", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIRAGWM", "url": "https://omabrowser.org/oma/group/PIRAGWM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZZ5", "url": "https://www.orthodb.org/?gene=Q3SZZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13505:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13505:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029457", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVVFYSSASFWAWMALLFSLAVYGASYHSMSSMARAAFSEDGALVDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGAPAPEHNEKRQRRQERRQMKRL", "length": 173, "header": "sp|Q3SZZ5-1|TM208_BOVIN Isoform 1 of Transmembrane protein 208 OS=Bos taurus OX=9913 GN=TMEM208 PE=2 SV=1 CANONICAL=Q3SZZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4L7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5/entry#A0AAA9S4L7-1", "sequence": { "sequence": "MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVVFYSSASFWAWMALLFSLAVYGASYHSMSSMARAAFSEDGALVDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYIWSFWLLVRGLRLPRRSWSI", "length": 141, "header": "tr|A0AAA9S4L7-1|A0AAA9S4L7_BOVIN Computationally mapped isoform of Transmembrane protein 208 OS=Bos taurus OX=9913 GN=TMEM208 PE=3 SV=1 CANONICAL=Q3SZZ5-1" }, "locus": { "chromosome": "18", "start_pos": 34857368, "end_pos": 34855637, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122759.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122759.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080116.1" } ] } }, { "isoform_ac": "Q3SZZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5/entry#Q3SZZ5-1", "sequence": { "sequence": "MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVVFYSSASFWAWMALLFSLAVYGASYHSMSSMARAAFSEDGALVDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGAPAPEHNEKRQRRQERRQMKRL", "length": 173, "header": "sp|Q3SZZ5-1|TM208_BOVIN Isoform 1 of Transmembrane protein 208 OS=Bos taurus OX=9913 GN=TMEM208 PE=2 SV=1 CANONICAL=Q3SZZ5-1" }, "locus": { "chromosome": "18", "start_pos": 34857562, "end_pos": 34855637, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003002.4", "url": "https://www.ensembl.org/id/ENSBTAT00000003002.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003002.2", "url": "https://www.ensembl.org/id/ENSBTAP00000003002.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507222", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507222", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZGI8-1", "protein_name": "Transmembrane protein 208", "gene_name": "TMEM208", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPKGKAGTKGKKQIFEENRETLRFYLRIILGASAVYAAVNLVVFYPAASAWTWLAFAFSSAVYGASYRSMSSMARPAFADDGSLADGGIDLNMEQGMAEHLKDVILLTAMVQVLSCFSLYVWYFWLLAPGRALYLLWVNILGPWFTAESSAPGQEPNEKKQRRQERRQMKRF", "length": 173 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1ZA77-1", "protein_name": "Transmembrane protein 208", "gene_name": "Tmem208", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAPQQKGKQGTKGAKQIVEENKTTLTFYRNMAIGCAAPALLLSFLVFEVTKTSVFMHILSLLILGSSYQFMAFMSQAKYSESGALLDSGNDLNMEGGIAENVKDLIILTSGTLLLALISNYFWLVLLLAPIRAGWMLWGSVIQPWLSQRNAQDDNPQVDEKKQKKMDRRMRRMR", "length": 174 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O82222-1", "protein_name": "Transmembrane protein (DUF788)", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MANQGAKKRKEENAKHMAKLRRIIIASNAVYFVVRMLIFYSSFTWKHWIGLVITSLAYAFPYKQLDQMAKPSVTDDGELIDGGFDMTTGGICGYLHDVIYITCFVQLASIITGKFWYTYLVIPAFGVYKASGLIRGFMSQGSEGGVEDEKSRKKREKMERKASRGQVVKTRTR", "length": 173 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54UB0-1", "protein_name": "Transmembrane protein 208 homolog", "gene_name": "tmem208", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MANSGAKKRKTQNEKELFKVRLIMAAGTIPYILYRVVYHSETFGGWLWFAYLSLNALNMFAYYIITSMCKLTYDNNGELIDGGSDLNQGGMTEYYFDIIYVCCIIQGLGLISDKCLYLILVIPAFAIFKIWKTFIGPYLASRNQQQQQPQEEKSKRREKMEKKQEKQKVKYVK", "length": 173 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6NYP0-1", "protein_name": "Transmembrane protein 208", "gene_name": "tmem208", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAPKGKVGTKGKKQIHEENQDTLKFYSRIILGANAIYIAVNLLLFYNSSSFWTWFSLMFAVAVYVGSYRSMSAMAKPAFAEDGSLLDGGIDLNMEQGMAEHLKDVILLTAIVQVLSTLSSYFWYLWLLAPARALHLLWVNFLGPWFSADSQAAPEENEKNDKKQRRQERRQMRRF", "length": 175 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BTX3-1", "protein_name": "Transmembrane protein 208", "gene_name": "TMEM208", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPKGKVGTRGKKQIFEENRETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEKRQRRQERRQMKRL", "length": 173 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR96-1", "protein_name": "Transmembrane protein 208", "gene_name": "Tmem208", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWMALGFSLAVYGASYHSMSSMARASFSEDGSLMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGAPAPELNEKRQRRQERRQMKRL", "length": 173 }, "evidence": [ { "id": "Q3SZZ5", "url": "https://omabrowser.org/oma/group/Q3SZZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ], "pmid": "" }, { "name": "vacuole", "id": "GO:0005773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005773", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ], "pmid": "" }, { "name": "vacuolar protein processing", "id": "GO:0006624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006624", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 173, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZZ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DM7-1", "uniprot_ac": "Q58DM7", "uniprot_id": "OXND1_BOVIN", "mass": { "chemical_mass": 34597.0, "monoisotopic_mass": 34597.0 }, "refseq": { "ac": "NP_001030262", "name": "oxidoreductase NAD-binding domain-containing protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030262" }, "gene_names": [ { "name": "OXNAD1", "type": "recommended", "evidence": [ { "id": "Q58DM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM7" } ] }, { "name": "OXNAD1", "type": "synonym", "evidence": [ { "id": "NP_001030262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030262" } ] } ], "protein_names": [ { "name": "Oxidoreductase NAD-binding domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q58DM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM7/entry#names_and_taxonomy" } ] }, { "name": "1.-.-.-", "type": "synonym", "evidence": [ { "id": "Q58DM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM7/entry#names_and_taxonomy" } ] }, { "name": "oxidoreductase NAD-binding domain-containing protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030262" } ] }, { "name": "oxidoreductase NAD-binding domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030262" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DM7", "url": "https://www.uniprot.org/uniprotkb/Q58DM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OXNAD1", "url": "https://www.uniprot.org/uniprotkb/Q58DM7", "locus": { "chromosome": "1", "start_pos": 153318616, "end_pos": 153274504, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004891", "url": "https://www.ensembl.org/id/ENSBTAG00000004891" } ] } } ], "crossref": [ { "id": "Q58DM7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004891", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004891", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00322", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00322", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510462", "url": "https://www.ncbi.nlm.nih.gov/gene/510462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WIDFFIP", "url": "https://omabrowser.org/oma/group/WIDFFIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DM7", "url": "https://www.orthodb.org/?gene=Q58DM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46505:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46505:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030262", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4T2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4T2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4T2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4T2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DM7", "url": "https://www.uniprot.org/uniprotkb/Q58DM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DM7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVVIPRLLRGSLGAICTQAALLRSTPSAFRYLTRSSVMKSKRRPDHLERTADVVRQEVVSAAKVCGVASESPSVKRLCLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPRLLEQERMIELAVKHANHPPALWIHNQCTLDSEVAVRVGGEFFFDPKPTDASRNLVLIAGGVGINPLLSILRHAADLLRERASKGQGYEMGTVRLLYSAKDTSELLFKKNILDLVNEFPEKIACSLHVTKQTTQITADLRPYITEGRITQKEIRDHISKETLFYICGPPPMTDFFSKELESSRVPREHICFEKWW", "length": 309, "header": "sp|Q58DM7-1|OXND1_BOVIN Isoform 1 of Oxidoreductase NAD-binding domain-containing protein 1 OS=Bos taurus OX=9913 GN=OXNAD1 PE=2 SV=1 CANONICAL=Q58DM7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4T2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DM7/entry#A0AAA9S4T2-1", "sequence": { "sequence": "MVVVIPRLLRGSLGAICTQAALLRSTPSAFRYLTRSSVMKSKRRPDHLERTADVVRQEIFLHIQTTEGLIHQPEGVHGLGNKGSSPVTSVVSAAKVCGVASESPSVKRLCLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPRLLEQERMIELAVKHANHPPALWIHNQCTLDSEVAVRVGGEFFFDPKPTDASRNLVLIAGGVGINPLLSILRHAADLLRERASKGQGYEMGTVRLLYSAKDTSELLFKKNILDLVNEFPEKIACSLHVTKQTTQITADLRPYITEGRITQKEIRDHISKETLFYICGPPPMTDFFSKELESSRVPREHICFEKWW", "length": 340, "header": "tr|A0AAA9S4T2-1|A0AAA9S4T2_BOVIN Computationally mapped isoform of Oxidoreductase NAD-binding domain-containing protein 1 OS=Bos taurus OX=9913 GN=OXNAD1 PE=4 SV=1 CANONICAL=Q58DM7-1" }, "locus": { "chromosome": "1", "start_pos": 153318207, "end_pos": 153276742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097695.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097695.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078243.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078243.1" } ] } }, { "isoform_ac": "Q58DM7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DM7/entry#Q58DM7-1", "sequence": { "sequence": "MVVVIPRLLRGSLGAICTQAALLRSTPSAFRYLTRSSVMKSKRRPDHLERTADVVRQEVVSAAKVCGVASESPSVKRLCLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPRLLEQERMIELAVKHANHPPALWIHNQCTLDSEVAVRVGGEFFFDPKPTDASRNLVLIAGGVGINPLLSILRHAADLLRERASKGQGYEMGTVRLLYSAKDTSELLFKKNILDLVNEFPEKIACSLHVTKQTTQITADLRPYITEGRITQKEIRDHISKETLFYICGPPPMTDFFSKELESSRVPREHICFEKWW", "length": 309, "header": "sp|Q58DM7-1|OXND1_BOVIN Isoform 1 of Oxidoreductase NAD-binding domain-containing protein 1 OS=Bos taurus OX=9913 GN=OXNAD1 PE=2 SV=1 CANONICAL=Q58DM7-1" }, "locus": { "chromosome": "1", "start_pos": 153318207, "end_pos": 153276742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006434.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006434.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006434.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006434.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DM7", "url": "https://www.uniprot.org/uniprotkb/Q58DM7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510462", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K466-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "Oxnad1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRRKTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFDPQPTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTSELLFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAETLFYVCGPPPMTDFFSKHLESSHVPKEHICFEKWW", "length": 310 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2MXL7-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "Oxnad1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAHAVFIPGLSRGTALWRLTASTLRHLTLTSIMKSKRKTDHLERTASALRREVVASAKVCEIAHESPTVKSLRLLVADKAFSFKAGQWVDFFIPGVSVVGGFSICSSPQLLEQERMIELAVKYTNHPPAIWVHNKCTLDSEVALRVGGEFFFDPQPTEAPRNLVLIAGGVGINPLLSILRHSADLHRDQANKGSSYEIGKIKLFYSAKNTSELLFKKNILDLVNEFPEKITCSLHVTKQTAQISEELKPYITEGRITEKEISNHVSAGTLFYICGPPPMTDFFSKQLEDSHVPKEHICFEKWW", "length": 303 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XF29-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "OXNAD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARVTTYMGFTIPHLLRSACRLCPAHSALVVLRHSASCYCTANGTIQSKRKMDHLERTANNFRQEVISQAKVCGITNESETVKRLRLAITNKDFTFKAGQWVDFFIPGVSVIGGFSMCSSPGLLEREGVLELAVKYTDHPPAHWIHTECTLDSEVALRVGGDFFFDPQPGDTPVKLVLIAGGVGINPLFSILLHVADLHGYQESKGNGYKMGTVKLYYSAKNTSELLFKKNILGLMSAFPGKITCRFHVTQQSSPICEELQPHVTEGRISEKDLEKHVSKDTLWYICGPPPMIESISELLYNSGVPRNCVFFEKWW", "length": 316 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A3KP77-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "oxnad1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSRRRTDHLERTASVHRQMELFSARVCDIISESDTVKRLRLEVAHPDFSFRAGQWVDFFIPGVDTVGGFSICSSPGLLKREGAIELAVKYARHPPAHWIHTECSVDSQVAVRVGGNFYFDPQPSNPVVDLLLVAGGVGINPLYSILLHAADLHRHTHSHRYTPGHTHLCYSAKNTTELLFKDTIIDICHERPDKFSCHFHVTQQSSDIEPQLQPYTIRGRISAEELQRYVDPERTLCYLCGPPPMIEKVSSDLQSTGLPEDRILFEKWW", "length": 270 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RS78-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "OXNAD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTLMIPGLLRGSVGAICLQAASWRLTHRTLRHLTLSSLMKSKRKTDHLERTADVLRREVVSVAKVCGVAHESPSVKRLRLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPRLLEQERIIELAVKYTNHPPALWIHNQCTLDSEVAVRVGGEFFFDPQPADASRNLVLIAGGVGINPLLSILRHVADLHREWANKGSGYKVGTIKLFYSAKNTSELLFKKNILDLVNEFPEKIACSLHVTKQTTQISADLKPYITEGRLTEKEIRDHISKETLFYLCGPPPMTDFFSKELARSHIPREHICFEKWW", "length": 309 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VE38-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "Oxnad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAHVALIPGLSRGSVGAVCTQAASWGLKASTLRHLTLASIIKSRRKTDHLERTASVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPGVSVVGGFSICSSPQRLERDRIIELAVKYADHPPAVWVHNKCTLDSEVALRVGGEFFFDPQPTDAPRNLILIAGGVGINPLLSILRHSADLHRDHADKGRSYEIGTVKLFYSAKNTSELLFKKDILDLVHEFPEKISCSFHVTKQTAQISAELKPYVTDGRITEKEIRDHISAETLFYVCGPPPMTDFFSKHLESCHVPKEHICFEKWW", "length": 311 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96HP4-1", "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "OXNAD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKSKRKTDHMERTASVLRREIVSAAKVCGAASESPSVKSLRLLVADQDFSFKAGQWVDFFIPGVSVVGGFSICSSPRLLEQERVIELAVKYTNHPPALWVHNTCTLDCEVAVRVGGEFFFDPQPADASRNLVLIAGGVGINPLLSILRHAADLLREQANKRNGYEIGTIKLFYSAKNTSELLFKKNILDLVNEFPEKIACSLHVTKQTTQINAELKPYITEGRITEKEIRDHISKETLFYICGPPPMTDFFSKQLENNHVPKEHICFEKWW", "length": 312 }, "evidence": [ { "id": "Q58DM7", "url": "https://omabrowser.org/oma/group/Q58DM7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q58DM7", "url": "https://www.uniprot.org/uniprotkb/Q58DM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DM7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DM7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DM7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM7" }, { "id": "PRU00716", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00716" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding FR-type", "eco_id": "ECO_0000255", "start_pos": 47, "end_pos": 161, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZCK5-1", "uniprot_ac": "Q3ZCK5", "uniprot_id": "CCNC_BOVIN", "mass": { "chemical_mass": 33201.0, "monoisotopic_mass": 33201.0 }, "refseq": { "ac": "NP_001029530", "name": "cyclin-C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029530" }, "gene_names": [ { "name": "CCNC", "type": "recommended", "evidence": [ { "id": "Q3ZCK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ] }, { "name": "CCNC", "type": "synonym", "evidence": [ { "id": "NP_001029530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029530" } ] } ], "protein_names": [ { "name": "Cyclin-C", "type": "recommended", "evidence": [ { "id": "Q3ZCK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#names_and_taxonomy" } ] }, { "name": "cyclin-C", "type": "synonym", "evidence": [ { "id": "NP_001029530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029530" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5#function" }, { "database": "UniProtKB", "id": "A0AAA9S6P9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P9#function" }, { "database": "UniProtKB", "id": "ARBA00025028", "url": "https://www.uniprot.org/uniprotkb/ARBA00025028#function" }, { "database": "UniProtKB", "id": "A0AAA9SGV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV9#function" }, { "database": "UniProtKB", "id": "A0AAA9SZX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX4#function" }, { "database": "UniProtKB", "id": "A0AAA9TTT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTT8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNC", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5", "locus": { "chromosome": "9", "start_pos": 50272426, "end_pos": 50244002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015744", "url": "https://www.ensembl.org/id/ENSBTAG00000015744" } ] } } ], "crossref": [ { "id": "Q3ZCK5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20514", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20514", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509717", "url": "https://www.ncbi.nlm.nih.gov/gene/509717", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509717", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509717", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLLHPPH", "url": "https://omabrowser.org/oma/group/CLLHPPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCK5", "url": "https://www.orthodb.org/?gene=Q3ZCK5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16899", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16899", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173796", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9841922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029530", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCK5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVLECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS", "length": 283, "header": "sp|Q3ZCK5-1|CCNC_BOVIN Isoform 1 of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=2 SV=1 CANONICAL=Q3ZCK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6P9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#A0AAA9S6P9-1", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVLECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALVIDYSLHVNFQ", "length": 210, "header": "tr|A0AAA9S6P9-1|A0AAA9S6P9_BOVIN Computationally mapped isoform of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=3 SV=1 CANONICAL=Q3ZCK5-1" }, "locus": { "chromosome": "9", "start_pos": 50262020, "end_pos": 50244099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077835.1" } ] } }, { "isoform_ac": "A0AAA9SGV9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#A0AAA9SGV9-1", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVLECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSCKYHCNFLLLKI", "length": 278, "header": "tr|A0AAA9SGV9-1|A0AAA9SGV9_BOVIN Computationally mapped isoform of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=3 SV=1 CANONICAL=Q3ZCK5-1" }, "locus": { "chromosome": "9", "start_pos": 50272333, "end_pos": 50244099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127724.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127724.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083131.1" } ] } }, { "isoform_ac": "A0AAA9SZX4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#A0AAA9SZX4-1", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVLECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNRNSLSDSSLVAGPEAARC", "length": 283, "header": "tr|A0AAA9SZX4-1|A0AAA9SZX4_BOVIN Computationally mapped isoform of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=3 SV=1 CANONICAL=Q3ZCK5-1" }, "locus": { "chromosome": "9", "start_pos": 50267966, "end_pos": 50244099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090975.1" } ] } }, { "isoform_ac": "A0AAA9TTT8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#A0AAA9TTT8-1", "sequence": { "sequence": "GGGDYCLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVSILYKIKLLDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSGSQLSMYIRSFRLGGKGQKGNYPS", "length": 283, "header": "tr|A0AAA9TTT8-1|A0AAA9TTT8_BOVIN Computationally mapped isoform of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=3 SV=1 CANONICAL=Q3ZCK5-1" }, "locus": { "chromosome": "9", "start_pos": 50267758, "end_pos": 50250273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131576.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131576.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100499.1" } ] } }, { "isoform_ac": "Q3ZCK5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5/entry#Q3ZCK5-1", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYKMNHVLECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS", "length": 283, "header": "sp|Q3ZCK5-1|CCNC_BOVIN Isoform 1 of Cyclin-C OS=Bos taurus OX=9913 GN=CCNC PE=2 SV=1 CANONICAL=Q3ZCK5-1" }, "locus": { "chromosome": "9", "start_pos": 50268580, "end_pos": 50244099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037858.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037858.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037680.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037680.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 275, "end_pos": 275, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "site_lbl": "Ser275" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509717", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509717", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-2173796", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "resource": "Reactome", "description": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" }, { "id": "R-BTA-9841922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "resource": "Reactome", "description": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis" } ], "orthologs": [ { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS", "length": 283 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P25008-1", "protein_name": "Cyclin-C", "gene_name": "CycC", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGNFWQSSHSQQWILDKPDLLRERQHDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSAIKTKFSYAYAQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLRTDVCLLYPPYQIAIACLQIACVILQKDATKQWFAELNVDLDKVQEIVRAIVNLYELWKDWKEKDEIQMLLSKIPKPKPPPQR", "length": 267 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P39947-1", "protein_name": "Cyclin-C", "gene_name": "Ccnc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTSLIAATTSVLKTRFSYASPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS", "length": 278 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47821-1", "protein_name": "RNA polymerase II holoenzyme cyclin-like subunit", "gene_name": "SSN8", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVMDSKQNGIEQSITKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLIKASVREINLYMLVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKVTEFEFYLLEELESYLIVHHPYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYINDVHLLYPPHIIAVACLFITISIHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFMAESLVDLEEVMDTIQEQITLYDHWDKYHEQWIKFLLHTLYLRPASAI", "length": 323 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q62447-1", "protein_name": "Cyclin-C", "gene_name": "Ccnc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS", "length": 283 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86KE7-1", "protein_name": "Cyclin-C", "gene_name": "cycC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAANFWESSHCTEWLLDRNKIEESNPKDKQYLTPIELKKLRTHYCFVIQNLGNALKLRQRAISTAIVYFKRFYLKNSFVDCEPRLVAVTCLYLSSKVEECITQAKKCAAKMKEIDHSFNYLMNDILECEFFVLEELDFCLIIYHPYKSLPFYLQSSGLDPASIEIIWGIVNDSYRTDVCLLYPPFVVGLGCILLGSYLLKKDIKQWLSELNVEMKDIWEVSKDLIDYYEFEKQQSLQNQSELDLLYNKLPIRNKK", "length": 255 }, "evidence": [ { "id": "Q3ZCK5", "url": "https://omabrowser.org/oma/group/Q3ZCK5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "CKM complex", "id": "GO:1990508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990508", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "G0 to G1 transition", "id": "GO:0045023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045023", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCK5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 283, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCK5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCK5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 275 ], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCH9-1", "uniprot_ac": "Q3ZCH9", "uniprot_id": "HDHD2_BOVIN", "mass": { "chemical_mass": 28594.0, "monoisotopic_mass": 28594.0 }, "refseq": { "ac": "NP_001030194", "name": "haloacid dehalogenase-like hydrolase domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030194" }, "gene_names": [ { "name": "HDHD2", "type": "recommended", "evidence": [ { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ] }, { "name": "HDHD2", "type": "synonym", "evidence": [ { "id": "NP_001030194", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030194" } ] } ], "protein_names": [ { "name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9/entry#names_and_taxonomy" } ] }, { "name": "haloacid dehalogenase-like hydrolase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001030194", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030194" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HDHD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9", "locus": { "chromosome": "24", "start_pos": 46800380, "end_pos": 46847451, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011893", "url": "https://www.ensembl.org/id/ENSBTAG00000011893" } ] } } ], "crossref": [ { "id": "Q3ZCH9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011893", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011893", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07509", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07509", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505403", "url": "https://www.ncbi.nlm.nih.gov/gene/505403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "194261", "url": "https://www.iedb.org/epitope/194261", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR006355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505403", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKPIESW", "url": "https://omabrowser.org/oma/group/RKPIESW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCH9", "url": "https://www.orthodb.org/?gene=Q3ZCH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19288:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19288:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q3ZCH9", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q3ZCH9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001030194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030194", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCH9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRATSVMVRFVTNTTKESKQDLLERLKKLEFDISEDEIFTSLTAARNLVEQKQVRPMLLVDDRALPDFKGIQTSDPNAVVIGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEETVMIGDDCRDDVGGAQNAGMRGILVKTGKYRAADEDKINPAPYLTCESFPHAVDHILQHLL", "length": 259, "header": "sp|Q3ZCH9-1|HDHD2_BOVIN Isoform 1 of Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Bos taurus OX=9913 GN=HDHD2 PE=2 SV=1 CANONICAL=Q3ZCH9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6S7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9/entry#A0AAA9S6S7-1", "sequence": { "sequence": "MATRRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRATSVMVRFVTNTTKESKQDLLERLKKLEFDISEDEIFTSLTAARNLVEQKQVRPMLLVDDRALPDFKGIQTSDPNAVVIGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEETVMIGDDCRDDVGGAQNAGMRGILVKTVLQNAHHVRSAELGD", "length": 240, "header": "tr|A0AAA9S6S7-1|A0AAA9S6S7_BOVIN Computationally mapped isoform of Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Bos taurus OX=9913 GN=HDHD2 PE=1 SV=1 CANONICAL=Q3ZCH9-1" }, "locus": { "chromosome": "24", "start_pos": 46832686, "end_pos": 46801927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123819.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123819.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080885.1" } ] } }, { "isoform_ac": "Q3ZCH9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9/entry#Q3ZCH9-1", "sequence": { "sequence": "MATRRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRATSVMVRFVTNTTKESKQDLLERLKKLEFDISEDEIFTSLTAARNLVEQKQVRPMLLVDDRALPDFKGIQTSDPNAVVIGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEETVMIGDDCRDDVGGAQNAGMRGILVKTGKYRAADEDKINPAPYLTCESFPHAVDHILQHLL", "length": 259, "header": "sp|Q3ZCH9-1|HDHD2_BOVIN Isoform 1 of Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Bos taurus OX=9913 GN=HDHD2 PE=2 SV=1 CANONICAL=Q3ZCH9-1" }, "locus": { "chromosome": "24", "start_pos": 46832686, "end_pos": 46801126, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023026.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023026.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023026.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023026.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012-06-01", "authors": "Thommen Daniela S, Schuster Heiko, Keller Mario, Kapoor Sarika, Weinzierl Andreas O, Chennakesava Cuddapah S, Wang Xueya, Rohrer Lucia, von Eckardstein Arnold, Stevanovic Stefan, Biedermann Barbara C", "evidence": [ { "database": "IEDB", "id": "194261", "url": "https://www.iedb.org/epitope/194261" } ], "reference": [ { "type": "PubMed", "id": "22544926", "url": "https://glygen.org/publication/PubMed/22544926" } ] } ], "pathway": [ { "id": "bta:505403", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505403", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RZX9-1", "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "HDHD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAARRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRATSVMIRFVTNTTKESKQDLLERLKKLEFDISEDEIFTSLTAARNLVEQKQVRPMLLVDDRALPDFKGIETGDPNAVVIGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDSKATVVGKPEKTFFLEALRGAGCEPEEAVMIGDDCRDDVGGAQNVGMLGILVKTGKYRAADEAKINPPPYLTCESFPHAVDHILQHLL", "length": 259 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P85007-1", "protein_name": "Immediate early response 3-interacting protein 1", "gene_name": "Ier3ip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFTLYSLMQAALLCVNAIAVLHEERFLKNIGWGTDQGIGGFGEEPGIKSQLLNLIRSVRTVMRVPLIIVNSITIVLLLLFG", "length": 82 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UGR5-1", "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "Hdhd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARRALKAVLVDLNGTLHIEDAAVPGAQEALKRLRATSVMVRFVTNTTKESKKDLLERLKKLEFEISEDEIFTSLTAARNLIEQKQVRPMLLVDDRALPEFTGVQTQDPNAVVIGLAPEHFHYQLLNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKAMVVGKPEKTFFLEALRDADCAPEEAVMIGDDCRDDVDGAQNIGMLGILVKTGKYKAADEEKINPPPYLTCESFPHAVDHILQHLL", "length": 259 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYR6-1", "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "Hdhd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARRVLKAVLVDLSGTLHIEDAAVPGAQEALKRLRAASVMVRFVTNTTKESKRDLLERLRKLEFDISEEEIFTSLTAARNLIEQRQVRPMLLVDDRALPDFTGVQTHDPNAVVIGLAPEHFHYQLLNEAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKAVVVGKPEKTFFLEALRDTDCAPEEAVMIGDDCRDDVDGAQNIGMLGILVKTGKYKAADEEKINPPPYLTCESFPHAVDHILQHLL", "length": 259 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H0R4-1", "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "HDHD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDFKGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL", "length": 259 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VLM9-1", "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "15010468", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSIKGALIDLSGTLHVEDEPTPNAVEALKRLRDSGVLVKFVTNTTKDSKATLHERLCRIGFQLDASEIYSSLSAAVSYVENERLNPYYILSEDARQDFPPEDTRRYKDSVVIGLAPKAFNYEQLNEAFNVLLENKNHKLIAVHQGKYYKRAEGLALGPGCFVKGLEFATGRTAKVIGKPNPYFFEGALAGRDPASCVMIGDDANDDIVGAMSMGMQGILVKTGKYLPDVKPSPPPTALLENFAEAVDWIIQKNQS", "length": 255 }, "evidence": [ { "id": "Q3ZCH9", "url": "https://omabrowser.org/oma/group/Q3ZCH9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "pmid": "" }, { "name": "phosphatase activity", "id": "GO:0016791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCH9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 259, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9#function" }, { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "binding_site_uniprot": 13, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 13, "end_pos": 13, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9#function" }, { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "binding_site_uniprot": 15, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 15, "end_pos": 15, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9#function" }, { "id": "Q3ZCH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH9" } ], "binding_site_uniprot": 204, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 204, "end_pos": 204, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 47, "end_pos": 49 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DG5-1", "uniprot_ac": "Q58DG5", "uniprot_id": "F110A_BOVIN", "mass": { "chemical_mass": 31475.0, "monoisotopic_mass": 31475.0 }, "refseq": { "ac": "NP_001014961", "name": "protein FAM110A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014961" }, "gene_names": [ { "name": "FAM110A", "type": "recommended", "evidence": [ { "id": "Q58DG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ] }, { "name": "C20orf55", "type": "synonym", "evidence": [ { "id": "NP_001014961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014961" } ] }, { "name": "FAM110A", "type": "synonym", "evidence": [ { "id": "NP_001014961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014961" } ] } ], "protein_names": [ { "name": "Protein FAM110A", "type": "recommended", "evidence": [ { "id": "Q58DG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG5/entry#names_and_taxonomy" } ] }, { "name": "protein FAM110A", "type": "synonym", "evidence": [ { "id": "NP_001014961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014961" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM110A", "url": "https://www.uniprot.org/uniprotkb/Q58DG5", "locus": { "chromosome": "13", "start_pos": 60258547, "end_pos": 60290863, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008638", "url": "https://www.ensembl.org/id/ENSBTAG00000008638" } ] } } ], "crossref": [ { "id": "Q58DG5", "url": "https://alphafold.ebi.ac.uk/entry/Q58DG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008638", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008638", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540118", "url": "https://www.ncbi.nlm.nih.gov/gene/540118", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540118", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540118", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GCRPHLD", "url": "https://omabrowser.org/oma/group/GCRPHLD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DG5", "url": "https://www.orthodb.org/?gene=Q58DG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014961", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S775", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S775", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S775-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S775-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YSM6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YSM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC", "length": 295, "header": "sp|Q58DG5-1|F110A_BOVIN Isoform 1 of Protein FAM110A OS=Bos taurus OX=9913 GN=FAM110A PE=2 SV=1 CANONICAL=Q58DG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S775-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG5/entry#A0AAA9S775-1", "sequence": { "sequence": "MEMQPGRGKVSKEVWTLPSGSSVGGGDPDTGTNRISGGWRTMKRNPLWSPAASFLLGFLSSYFSSLLRQKPSGNVTAMPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC", "length": 372, "header": "tr|A0AAA9S775-1|A0AAA9S775_BOVIN Computationally mapped isoform of Family with sequence similarity 110 member A OS=Bos taurus OX=9913 GN=FAM110A PE=3 SV=1 CANONICAL=Q58DG5-1" }, "locus": { "chromosome": "13", "start_pos": 60290764, "end_pos": 60260236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079760.1" } ] } }, { "isoform_ac": "A0AAA9T8G0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG5/entry#A0AAA9T8G0-1", "sequence": { "sequence": "MKRNPLWSPAASFLLGFLSSYFSSLLRQKPSGNVTAMPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC", "length": 331, "header": "tr|A0AAA9T8G0-1|A0AAA9T8G0_BOVIN Computationally mapped isoform of Family with sequence similarity 110 member A OS=Bos taurus OX=9913 GN=FAM110A PE=3 SV=1 CANONICAL=Q58DG5-1" }, "locus": { "chromosome": "13", "start_pos": 60278831, "end_pos": 60260236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117356.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117356.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092901.1" } ] } }, { "isoform_ac": "A0AAF6YSM6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG5/entry#A0AAF6YSM6-1", "sequence": { "sequence": "MPIPTSGPGARQGRLRPPPGRSSCLDVPVAWRCSRAEPLWSPAASFLLGFLSSYFSSLLRQKPSGNVTAMPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC", "length": 364, "header": "tr|A0AAF6YSM6-1|A0AAF6YSM6_BOVIN Computationally mapped isoform of Family with sequence similarity 110 member A OS=Bos taurus OX=9913 GN=FAM110A PE=3 SV=1 CANONICAL=Q58DG5-1" }, "locus": { "chromosome": "13", "start_pos": 60290853, "end_pos": 60260236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011392.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011392.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011392.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011392.5" } ] } }, { "isoform_ac": "Q58DG5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG5/entry#Q58DG5-1", "sequence": { "sequence": "MPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC", "length": 295, "header": "sp|Q58DG5-1|F110A_BOVIN Isoform 1 of Protein FAM110A OS=Bos taurus OX=9913 GN=FAM110A PE=2 SV=1 CANONICAL=Q58DG5-1" }, "locus": { "chromosome": "13", "start_pos": 60261120, "end_pos": 60260236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111251.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111251.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084379.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 140, "start_aa": "Thr", "end_pos": 140, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr140", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540118", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540118", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M225-1", "protein_name": "Protein FAM110A", "gene_name": "Fam110a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVDTLSPAAPAAPTLPFRLRTKVPSYLLPRPAVAGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPPLARQPFFSAARGPVLTPSRRALPCPGRRPQLDVDILTSLINLCDSPVSPAEASRTPGRAEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPTRLCPSPGNTATSSPGRPPGLQRSKSDLSERFFRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSHRSSATVEERALERVPYGVSVIERNARVIKWLYGLRQARDPPATEG", "length": 295 }, "evidence": [ { "id": "Q58DG5", "url": "https://omabrowser.org/oma/group/Q58DG5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S865-1", "protein_name": "Family with sequence similarity 110 member A", "gene_name": "FAM110A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPVDTLTPGARDTPAALPFRLRTKVPGYLLRRPADSGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRVLPGPGRRPQLDLDILSNLINLCDSPVSPAEASRTPGRVEGACQPPPATPPRPPPSTAAVRRVDVLPLPASPAQPCPSPGTAASSPARPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSATVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEG", "length": 295 }, "evidence": [ { "id": "Q58DG5", "url": "https://omabrowser.org/oma/group/Q58DG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G4XVC3-1", "protein_name": "Family with sequence similarity 110, member A", "gene_name": "Fam110a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVDTLSPGAPTTPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLARQPLFSPGSRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEANRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGAATTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERTLERVPYGVSVIERNARVIKWLYGLRQARDPPTTEG", "length": 296 }, "evidence": [ { "id": "Q58DG5", "url": "https://omabrowser.org/oma/group/Q58DG5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R184-1", "protein_name": "Protein FAM110A", "gene_name": "Fam110a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVDTLSPGAPATPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLVRQPLFSPGPRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEASRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGTTTTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERSLDRVPYGVSVIERNARVIKWLYGLRQARDPPTTEG", "length": 296 }, "evidence": [ { "id": "Q58DG5", "url": "https://omabrowser.org/oma/group/Q58DG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQ89-1", "protein_name": "Protein FAM110A", "gene_name": "FAM110A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLSKQPLFSPETRRTVLTPSRRALPGPCRRPQLDLDILSSLIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRPPPSTSAVRRVDVRPLPASPARPCPSPGPAAASSPARPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPGSSEGGCSRRSSVTVEERARERVPYGVSVVERNARVIKWLYGLRQARESPAAEG", "length": 295 }, "evidence": [ { "id": "Q58DG5", "url": "https://omabrowser.org/oma/group/Q58DG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "Q58DG5", "url": "https://www.uniprot.org/uniprotkb/Q58DG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DG5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DG5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DG5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 140 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32KN5-1", "uniprot_ac": "Q32KN5", "uniprot_id": "DNAL4_BOVIN", "mass": { "chemical_mass": 12009.0, "monoisotopic_mass": 12009.0 }, "refseq": { "ac": "NP_001074387", "name": "dynein axonemal light chain 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074387" }, "gene_names": [ { "name": "DNAL4", "type": "recommended", "evidence": [ { "id": "Q32KN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ] }, { "name": "DNAL4", "type": "synonym", "evidence": [ { "id": "NP_001074387", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074387" } ] } ], "protein_names": [ { "name": "Dynein axonemal light chain 4", "type": "recommended", "evidence": [ { "id": "Q32KN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#names_and_taxonomy" } ] }, { "name": "dynein axonemal light chain 4", "type": "synonym", "evidence": [ { "id": "NP_001074387", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074387" } ] }, { "name": "dynein light chain 4, axonemal", "type": "synonym", "evidence": [ { "id": "NP_001074387", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074387" } ] } ], "function": [ { "annotation": "Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5#function" }, { "database": "UniProtKB", "id": "A0AAA9S7U1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U1#function" }, { "database": "UniProtKB", "id": "ARBA00057688", "url": "https://www.uniprot.org/uniprotkb/ARBA00057688#function" }, { "database": "UniProtKB", "id": "A0AAA9T9A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A7#function" }, { "database": "UniProtKB", "id": "A0AAA9TTP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAL4", "url": "https://www.uniprot.org/uniprotkb/Q32KN5", "locus": { "chromosome": "5", "start_pos": 110402228, "end_pos": 110414559, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049822", "url": "https://www.ensembl.org/id/ENSBTAG00000049822" } ] } } ], "crossref": [ { "id": "Q32KN5", "url": "https://alphafold.ebi.ac.uk/entry/Q32KN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049822", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049822", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21453", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21453", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618379", "url": "https://www.ncbi.nlm.nih.gov/gene/618379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618379", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618379", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CDMTDEM", "url": "https://omabrowser.org/oma/group/CDMTDEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KN5", "url": "https://www.orthodb.org/?gene=Q32KN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11886", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11886", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11886:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11886:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-177504", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177504", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001074387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074387", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS", "length": 105, "header": "sp|Q32KN5-1|DNAL4_BOVIN Isoform 1 of Dynein axonemal light chain 4 OS=Bos taurus OX=9913 GN=DNAL4 PE=3 SV=1 CANONICAL=Q32KN5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7U1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#A0AAA9S7U1-1", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHESLVGGTGARLSIVRLRGSPRNLRCFFKHSPHEWGHRDGEATDPALSEFAVY", "length": 135, "header": "tr|A0AAA9S7U1-1|A0AAA9S7U1_BOVIN Computationally mapped isoform of Dynein light chain OS=Bos taurus OX=9913 GN=DNAL4 PE=3 SV=1 CANONICAL=Q32KN5-1" }, "locus": { "chromosome": "5", "start_pos": 110406932, "end_pos": 110402511, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120697.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120697.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079368.1" } ] } }, { "isoform_ac": "A0AAA9T9A7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#A0AAA9T9A7-1", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEAFPPKAVPLGAGSSHGQVLTSQRKAGVFSPLSCVPCPEPRPACASAAISR", "length": 134, "header": "tr|A0AAA9T9A7-1|A0AAA9T9A7_BOVIN Computationally mapped isoform of Dynein light chain OS=Bos taurus OX=9913 GN=DNAL4 PE=3 SV=1 CANONICAL=Q32KN5-1" }, "locus": { "chromosome": "5", "start_pos": 110406932, "end_pos": 110403562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094582.1" } ] } }, { "isoform_ac": "A0AAA9TTP3-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#A0AAA9TTP3-1", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHERCFFKHSPHEWGHRDGEATDPALSEFAVYGGGAQEPSCSNWT", "length": 126, "header": "tr|A0AAA9TTP3-1|A0AAA9TTP3_BOVIN Computationally mapped isoform of Dynein light chain OS=Bos taurus OX=9913 GN=DNAL4 PE=3 SV=1 CANONICAL=Q32KN5-1" }, "locus": { "chromosome": "5", "start_pos": 110406932, "end_pos": 110402472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098504.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098504.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100739.1" } ] } }, { "isoform_ac": "A0AAA9TZR7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#A0AAA9TZR7-1", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNEVLPSVAPRVLGDPC", "length": 65, "header": "tr|A0AAA9TZR7-1|A0AAA9TZR7_BOVIN Computationally mapped isoform of Dynein axonemal light chain 4 OS=Bos taurus OX=9913 GN=DNAL4 PE=4 SV=1 CANONICAL=Q32KN5-1" }, "locus": { "chromosome": "5", "start_pos": 110406932, "end_pos": 110405180, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128665.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128665.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102244.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102244.1" } ] } }, { "isoform_ac": "Q32KN5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN5/entry#Q32KN5-1", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS", "length": 105, "header": "sp|Q32KN5-1|DNAL4_BOVIN Isoform 1 of Dynein axonemal light chain 4 OS=Bos taurus OX=9913 GN=DNAL4 PE=3 SV=1 CANONICAL=Q32KN5-1" }, "locus": { "chromosome": "5", "start_pos": 110406932, "end_pos": 110403759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068279.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068279.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068101.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618379", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618379", "resource": "KEGG Pathway" }, { "id": "R-BTA-177504", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177504", "resource": "Reactome", "description": "Retrograde neurotrophin signalling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A5P7-1", "protein_name": "Dynein light chain", "gene_name": "Dnal4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGETEGKKEEADYKRLQTFPLVKHSDMPEEMRMETMELCVTACEKFSNNNESAAKMIKETMDKKFGSCWHVVIGEGFGFEITHEVKNLLYLFFGGTLAVCVWKCS", "length": 105 }, "evidence": [ { "id": "Q32KN5", "url": "https://omabrowser.org/oma/group/Q32KN5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A4F4L4-1", "protein_name": "Dynein axonemal light chain 4", "gene_name": "DNAL4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS", "length": 105 }, "evidence": [ { "id": "Q32KN5", "url": "https://omabrowser.org/oma/group/Q32KN5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O96015-1", "protein_name": "Dynein axonemal light chain 4", "gene_name": "DNAL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS", "length": 105 }, "evidence": [ { "id": "Q32KN5", "url": "https://omabrowser.org/oma/group/Q32KN5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCM4-1", "protein_name": "Dynein axonemal light chain 4", "gene_name": "Dnal4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGETEGKKEEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS", "length": 105 }, "evidence": [ { "id": "Q32KN5", "url": "https://omabrowser.org/oma/group/Q32KN5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ], "pmid": "" }, { "name": "dynein complex", "id": "GO:0030286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030286", "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule-based process", "id": "GO:0007017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", "evidence": [ { "database": "UniProtKB", "id": "Q32KN5", "url": "https://www.uniprot.org/uniprotkb/Q32KN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KN5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 105, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KN5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZR0-1", "uniprot_ac": "Q3SZR0", "uniprot_id": "AVPI1_BOVIN", "mass": { "chemical_mass": 16315.0, "monoisotopic_mass": 16315.0 }, "refseq": { "ac": "NP_001029932", "name": "arginine vasopressin-induced protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029932" }, "gene_names": [ { "name": "AVPI1", "type": "recommended", "evidence": [ { "id": "Q3SZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0" } ] }, { "name": "AVPI1", "type": "synonym", "evidence": [ { "id": "NP_001029932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029932" } ] } ], "protein_names": [ { "name": "Arginine vasopressin-induced protein 1", "type": "recommended", "evidence": [ { "id": "Q3SZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0/entry#names_and_taxonomy" } ] }, { "name": "AVP-induced protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029932" }, { "id": "Q3SZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0/entry#names_and_taxonomy" } ] }, { "name": "arginine vasopressin-induced protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029932" } ] } ], "function": [ { "annotation": "May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR0", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0#function" }, { "database": "UniProtKB", "id": "A0AAA9SFQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFQ8#function" }, { "database": "UniProtKB", "id": "ARBA00002403", "url": "https://www.uniprot.org/uniprotkb/ARBA00002403#function" }, { "database": "UniProtKB", "id": "A0AAA9S888", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S888#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZR0", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AVPI1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0", "locus": { "chromosome": "26", "start_pos": 18846873, "end_pos": 18854967, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023947", "url": "https://www.ensembl.org/id/ENSBTAG00000023947" } ] } } ], "crossref": [ { "id": "Q3SZR0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614488", "url": "https://www.ncbi.nlm.nih.gov/gene/614488", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614488", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614488", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWKKPGP", "url": "https://omabrowser.org/oma/group/NWKKPGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZR0", "url": "https://www.orthodb.org/?gene=Q3SZR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14350", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14350", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S888", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S888", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S888-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S888-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR0", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPASVVSEPPPWRAPPEVRGRKQAAANIFQDAELLQIQGLFQRSGDQLAEERAQIVWECAGDHRVAEALKRLRRKRPPRQKPLGPSVHHCSRLRTAEPCAPQSRATETASSEQHVNSRRASARIRRNWRKPGPTSYLHQIRH", "length": 144, "header": "sp|Q3SZR0-1|AVPI1_BOVIN Isoform 1 of Arginine vasopressin-induced protein 1 OS=Bos taurus OX=9913 GN=AVPI1 PE=2 SV=1 CANONICAL=Q3SZR0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S888-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0/entry#A0AAA9S888-1", "sequence": { "sequence": "MVPREISDFKSRLTLFQLLENRNTRSPCVGQDPQAWEGPTELLTSLPAPSSAPRMGTPASVVSEPPPWRAPPEVRGRKQAAANIFQDAELLQIQGLFQRSGDQLAEERAQIVWECAGDHRVAEALKRLRRKRPPRQKPLGPSVHHCSRLRTAEPCAPQSRATETASSEQHVNSRRASARIRRNWRKPGPTSYLHQIRH", "length": 198, "header": "tr|A0AAA9S888-1|A0AAA9S888_BOVIN Computationally mapped isoform of Arginine vasopressin-induced protein 1 OS=Bos taurus OX=9913 GN=AVPI1 PE=4 SV=1 CANONICAL=Q3SZR0-1" }, "locus": { "chromosome": "26", "start_pos": 18853060, "end_pos": 18847288, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122201.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122201.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081459.1" } ] } }, { "isoform_ac": "A0AAA9SFQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0/entry#A0AAA9SFQ8-1", "sequence": { "sequence": "MRRLKSIYLLGQLCSFMIQQCYVPREISDFKSRLTLFQLLENRNTRSPCVGQDPQAWEGPTELLTSLPAPSSAPRMGTPASVVSEPPPWRAPPEVRGRKQAAANIFQDAELLQIQGLFQRSGDQLAEERAQIVWECAGDHRVAEALKRLRRKRPPRQKPLGPSVHHCSRLRTAEPCAPQSRATETASSEQHVNSRRASARIRRNWRKPGPTSYLHQIRH", "length": 219, "header": "tr|A0AAA9SFQ8-1|A0AAA9SFQ8_BOVIN Computationally mapped isoform of Arginine vasopressin-induced protein 1 OS=Bos taurus OX=9913 GN=AVPI1 PE=4 SV=1 CANONICAL=Q3SZR0-1" }, "locus": { "chromosome": "26", "start_pos": 18849192, "end_pos": 18847288, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135775.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135775.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085014.1" } ] } }, { "isoform_ac": "Q3SZR0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0/entry#Q3SZR0-1", "sequence": { "sequence": "MGTPASVVSEPPPWRAPPEVRGRKQAAANIFQDAELLQIQGLFQRSGDQLAEERAQIVWECAGDHRVAEALKRLRRKRPPRQKPLGPSVHHCSRLRTAEPCAPQSRATETASSEQHVNSRRASARIRRNWRKPGPTSYLHQIRH", "length": 144, "header": "sp|Q3SZR0-1|AVPI1_BOVIN Isoform 1 of Arginine vasopressin-induced protein 1 OS=Bos taurus OX=9913 GN=AVPI1 PE=2 SV=1 CANONICAL=Q3SZR0-1" }, "locus": { "chromosome": "26", "start_pos": 18848668, "end_pos": 18847288, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032947.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032947.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032874.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032874.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614488", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614488", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZYA1-1", "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "AVPI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTPASVVSEPPPWQAPTEARGRKQASANIFQDAELLQIQGLFQRSGDQLAEERAQIIWECAGDQRVAEALKRLRRKRPPRQKPLDHSLHHCSRLRIPEPHAPLANPQSSATETASSEQYLNSRRTSARIRRNWGKPGPTGYLHQIRH", "length": 148 }, "evidence": [ { "id": "Q3SZR0", "url": "https://omabrowser.org/oma/group/Q3SZR0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GZX8-1", "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "Avpi1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGTPASVVSEPPLWQASTESRGRKQASANIFQDAELVQIQGLFQRSGDQLAEERAQIIWECAGDHRVAEALRRLRRKRPPRQNHCGRLRAPELGSTAADPQDSTTDMASGEQFGNSRRTSARVHRSWNKPGPTGYLHQIRH", "length": 141 }, "evidence": [ { "id": "Q3SZR0", "url": "https://omabrowser.org/oma/group/Q3SZR0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5T686-1", "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "AVPI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTPASVVSEPPPWQAPIEARGRKQASANIFQDAELLQIQALFQRSGDQLAEERAQIIWECAGDHRVAEALKRLRRKRPPRQKPLGHSLHHCSRLRILEPHSALANPQSATETASSEQYLHSRKKSARIRRNWRKSGPTSYLHQIRH", "length": 147 }, "evidence": [ { "id": "Q3SZR0", "url": "https://omabrowser.org/oma/group/Q3SZR0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VDA6-1", "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "Avpi1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTPASVVSEPPLWQVSTAQPRDRGRGRKQASANIFQDAELVQIQGLFQRSGDQLAEERAQIIWECAGDHRVAEALRRLRRKRPPRQNHCSRLRVPELGSTAADPQASTTDTASSEQFGNSRRTSARVHRNWNKPGPTGYLHQIRH", "length": 146 }, "evidence": [ { "id": "Q3SZR0", "url": "https://omabrowser.org/oma/group/Q3SZR0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D7H4-1", "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "Avpi1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTPASVVSEPPLWQVSTPQTRGRKQASANIFQDAELVQIQGLFQRSGDQLAEERAQIIWECAGDHRVAEALRRLRRKRPPKQNHCSRLRVPEPGSTASDPQASTTDTASSEQSGNSRRTSARAPRNWNKPGPTGYLHQIRH", "length": 142 }, "evidence": [ { "id": "Q3SZR0", "url": "https://omabrowser.org/oma/group/Q3SZR0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR0", "url": "https://www.uniprot.org/uniprotkb/Q3SZR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZR0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZR0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZR0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T126-1", "uniprot_ac": "Q3T126", "uniprot_id": "CNIH4_BOVIN", "mass": { "chemical_mass": 16049.0, "monoisotopic_mass": 16049.0 }, "refseq": { "ac": "NP_001029510", "name": "protein cornichon homolog 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510" }, "gene_names": [ { "name": "CNIH4", "type": "recommended", "evidence": [ { "id": "Q3T126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ] }, { "name": "CNIH-4", "type": "synonym", "evidence": [ { "id": "NP_001029510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510" } ] }, { "name": "CNIH4", "type": "synonym", "evidence": [ { "id": "NP_001029510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510" } ] } ], "protein_names": [ { "name": "Protein cornichon homolog 4", "type": "recommended", "evidence": [ { "id": "Q3T126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#names_and_taxonomy" } ] }, { "name": "CNIH-4", "type": "synonym", "evidence": [ { "id": "Q3T126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#names_and_taxonomy" } ] }, { "name": "Cornichon family AMPA receptor auxiliary protein 4", "type": "synonym", "evidence": [ { "id": "Q3T126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#names_and_taxonomy" } ] }, { "name": "cornichon homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001029510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510" } ] }, { "name": "protein cornichon homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001029510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510" } ] } ], "function": [ { "annotation": "Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126#function" }, { "database": "UniProtKB", "id": "Q9P003", "url": "https://www.uniprot.org/uniprotkb/Q9P003#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNIH4", "url": "https://www.uniprot.org/uniprotkb/Q3T126", "locus": { "chromosome": "16", "start_pos": 27547057, "end_pos": 27529034, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019471", "url": "https://www.ensembl.org/id/ENSBTAG00000019471" } ] } } ], "crossref": [ { "id": "Q3T126", "url": "https://alphafold.ebi.ac.uk/entry/Q3T126", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508912", "url": "https://www.ncbi.nlm.nih.gov/gene/508912", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508912", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508912", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HKKECFI", "url": "https://omabrowser.org/oma/group/HKKECFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T126", "url": "https://www.orthodb.org/?gene=Q3T126", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03311", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03311", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029510", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2I7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T126-1", "url": "https://www.uniprot.org/uniprotkb/Q3T126-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTLVTVLMLISLHWFIFLLNLPVAAWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND", "length": 139, "header": "sp|Q3T126-1|CNIH4_BOVIN Isoform 1 of Protein cornichon homolog 4 OS=Bos taurus OX=9913 GN=CNIH4 PE=2 SV=1 CANONICAL=Q3T126-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8I0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#A0AAA9S8I0-1", "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTLVTVLMLISLHWFIFLLNLPVAAWNIYRMILALIND", "length": 92, "header": "tr|A0AAA9S8I0-1|A0AAA9S8I0_BOVIN Computationally mapped isoform of Cornichon family AMPA receptor auxiliary protein 4 OS=Bos taurus OX=9913 GN=CNIH4 PE=3 SV=1 CANONICAL=Q3T126-1" }, "locus": { "chromosome": "16", "start_pos": 27543103, "end_pos": 27529115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081569.1" } ] } }, { "isoform_ac": "A0AAA9T2I7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#A0AAA9T2I7-1", "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTLVTVLMLISLHWFIFLLNLPVAAWNIYRGSRCPY", "length": 90, "header": "tr|A0AAA9T2I7-1|A0AAA9T2I7_BOVIN Computationally mapped isoform of Cornichon family AMPA receptor auxiliary protein 4 OS=Bos taurus OX=9913 GN=CNIH4 PE=3 SV=1 CANONICAL=Q3T126-1" }, "locus": { "chromosome": "16", "start_pos": 27545480, "end_pos": 27529115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129653.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129653.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090849.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090849.1" } ] } }, { "isoform_ac": "A0AAA9TJV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#A0AAA9TJV1-1", "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTLVTVLMLISLHWFIFLLNLPVAAWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMKS", "length": 134, "header": "tr|A0AAA9TJV1-1|A0AAA9TJV1_BOVIN Computationally mapped isoform of Cornichon family AMPA receptor auxiliary protein 4 OS=Bos taurus OX=9913 GN=CNIH4 PE=3 SV=1 CANONICAL=Q3T126-1" }, "locus": { "chromosome": "16", "start_pos": 27546053, "end_pos": 27529115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117272.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117272.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098638.1" } ] } }, { "isoform_ac": "Q3T126-1", "url": "https://www.uniprot.org/uniprotkb/Q3T126/entry#Q3T126-1", "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTLVTVLMLISLHWFIFLLNLPVAAWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND", "length": 139, "header": "sp|Q3T126-1|CNIH4_BOVIN Isoform 1 of Protein cornichon homolog 4 OS=Bos taurus OX=9913 GN=CNIH4 PE=2 SV=1 CANONICAL=Q3T126-1" }, "locus": { "chromosome": "16", "start_pos": 27543103, "end_pos": 27529115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140926.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140926.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107735.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107735.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508912", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508912", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTY0-1", "protein_name": "Cornichon family member 4", "gene_name": "Cnih4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAVVFLFSLLDCCSLIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTFVTVLMLVSLHWVIFLLNLPVATWNIYRFIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFYLLCFFMYLYSMILALIND", "length": 139 }, "evidence": [ { "id": "Q3T126", "url": "https://omabrowser.org/oma/group/Q3T126/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53173-1", "protein_name": "ER-derived vesicles protein ERV14", "gene_name": "ERV14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGAWLFILAVVVNCINLFGQVHFTILYADLEADYINPIELCSKVNKLITPEAALHGALSLLFLLNGYWFVFLLNLPVLAYNLNKIYNKVQLLDATEIFRTLGKHKRESFLKLGFHLLMFFFYLYRMIMALIAESGDDF", "length": 138 }, "evidence": [ { "id": "Q3T126", "url": "https://omabrowser.org/oma/group/Q3T126/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CX13-1", "protein_name": "Protein cornichon homolog 4", "gene_name": "Cnih4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAVVFLFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELVGHTIVTVLMLVSLHWFIFLLNLPVATWNIYRFIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFYLLCFFMYLYSMILALIND", "length": 139 }, "evidence": [ { "id": "Q3T126", "url": "https://omabrowser.org/oma/group/Q3T126/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P003-1", "protein_name": "Protein cornichon homolog 4", "gene_name": "CNIH4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND", "length": 139 }, "evidence": [ { "id": "Q3T126", "url": "https://omabrowser.org/oma/group/Q3T126/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VQL3-1", "protein_name": "Cornichon related", "gene_name": "cnir", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFLPETATFCITLLVYGAILLLLIYYVLTLADLECDYLNAQECCRRLNFWVIPKFGSHALLCVLLLLGGHWVMFLLNLPMVIWLFYELHRQRRDSLGVYDPVDIHSRGLLKVHLRNCMIYLGYYFVMFFVGLYCLISSLIKGDPIKRYEDDEIVTDF", "length": 157 }, "evidence": [ { "id": "Q3T126", "url": "https://omabrowser.org/oma/group/Q3T126/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "CCR5 chemokine receptor binding", "id": "GO:0031730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031730", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3T126", "url": "https://www.uniprot.org/uniprotkb/Q3T126" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T126-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 139, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T126-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T126" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LH1-1", "uniprot_ac": "Q32LH1", "uniprot_id": "DYDC1_BOVIN", "mass": { "chemical_mass": 20730.0, "monoisotopic_mass": 20730.0 }, "refseq": { "ac": "NP_001035661", "name": "DPY30 domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035661" }, "gene_names": [ { "name": "DYDC1", "type": "recommended", "evidence": [ { "id": "Q32LH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH1" } ] }, { "name": "DYDC1", "type": "synonym", "evidence": [ { "id": "NP_001035661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035661" } ] } ], "protein_names": [ { "name": "DPY30 domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q32LH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#names_and_taxonomy" } ] }, { "name": "DPY30 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001035661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035661" } ] } ], "function": [ { "annotation": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Plays a crucial role during acrosome biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGA7#function" }, { "database": "UniProtKB", "id": "ARBA00058296", "url": "https://www.uniprot.org/uniprotkb/ARBA00058296#function" }, { "database": "UniProtKB", "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1#function" }, { "database": "UniProtKB", "id": "Q9D9T0", "url": "https://www.uniprot.org/uniprotkb/Q9D9T0#function" }, { "database": "UniProtKB", "id": "Q8WWB3", "url": "https://www.uniprot.org/uniprotkb/Q8WWB3#function" }, { "database": "UniProtKB", "id": "A0AAA9S8L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L2#function" }, { "database": "UniProtKB", "id": "A0AAA9SVT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT0#function" }, { "database": "UniProtKB", "id": "A0AAA9TA24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYDC1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1", "locus": { "chromosome": "28", "start_pos": 35684949, "end_pos": 35741744, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032858", "url": "https://www.ensembl.org/id/ENSBTAG00000032858" } ] } } ], "crossref": [ { "id": "Q32LH1", "url": "https://alphafold.ebi.ac.uk/entry/Q32LH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032858", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032858", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22966", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22966", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613509", "url": "https://www.ncbi.nlm.nih.gov/gene/613509", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR007858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613509", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613509", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ELMFQQQ", "url": "https://omabrowser.org/oma/group/ELMFQQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LH1", "url": "https://www.orthodb.org/?gene=Q32LH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23356:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23356:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LH1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDVALNIDQDL", "length": 175, "header": "sp|Q32LH1-1|DYDC1_BOVIN Isoform 1 of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=1 SV=1 CANONICAL=Q32LH1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8L2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#A0AAA9S8L2-1", "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDVIDFHHGFNMKALLVFKTTIDLGVGEWE", "length": 194, "header": "tr|A0AAA9S8L2-1|A0AAA9S8L2_BOVIN Computationally mapped isoform of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=3 SV=1 CANONICAL=Q32LH1-1" }, "locus": { "chromosome": "28", "start_pos": 35741721, "end_pos": 35707835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080264.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080264.1" } ] } }, { "isoform_ac": "A0AAA9SVT0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#A0AAA9SVT0-1", "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDVGHGEGNGTPFQYSCLETPMDGGAW", "length": 191, "header": "tr|A0AAA9SVT0-1|A0AAA9SVT0_BOVIN Computationally mapped isoform of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=3 SV=1 CANONICAL=Q32LH1-1" }, "locus": { "chromosome": "28", "start_pos": 35741721, "end_pos": 35719798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087708.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087708.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088121.1" } ] } }, { "isoform_ac": "A0AAA9TA24-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#A0AAA9TA24-1", "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDVTAITQDCPERGCTESPASVGTDKVEQLPG", "length": 196, "header": "tr|A0AAA9TA24-1|A0AAA9TA24_BOVIN Computationally mapped isoform of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=3 SV=1 CANONICAL=Q32LH1-1" }, "locus": { "chromosome": "28", "start_pos": 35741721, "end_pos": 35722197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105362.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105362.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095554.1" } ] } }, { "isoform_ac": "A0AAF6ZGA7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#A0AAF6ZGA7-1", "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDRHELYSTRLLCPWDFPGK", "length": 184, "header": "tr|A0AAF6ZGA7-1|A0AAF6ZGA7_BOVIN Computationally mapped isoform of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=3 SV=1 CANONICAL=Q32LH1-1" }, "locus": { "chromosome": "28", "start_pos": 35741721, "end_pos": 35684950, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046647.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046647.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043925.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043925.4" } ] } }, { "isoform_ac": "Q32LH1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1/entry#Q32LH1-1", "sequence": { "sequence": "MESAYLHKFLGTCLTEGLAELARMRPVDPIEYLALWIYKYKKNVTMEKQRQEEMAQLEHEREVALMEQEMMERLRAEELLFQQQQLEFQLELEEQEKERQRIEELERAQEQFEKELRMSMENMAKEDTLHGEDGADSGKTLAEISDRYGAPNLSRVEELDEPMLSDVALNIDQDL", "length": 175, "header": "sp|Q32LH1-1|DYDC1_BOVIN Isoform 1 of DPY30 domain-containing protein 1 OS=Bos taurus OX=9913 GN=DYDC1 PE=1 SV=1 CANONICAL=Q32LH1-1" }, "locus": { "chromosome": "28", "start_pos": 35741721, "end_pos": 35719172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127385.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127385.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090330.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613509", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613509", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ADI0-1", "protein_name": "DPY30 domain-containing protein 1", "gene_name": "Dydc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESRYLQQCLGTCLTQGLAEVARVRPLDPIEYLALWIYKYKENESMEQLRQKELIALEHERELAMMEQEMMDRLKAEELLFQQQLAFQLELEMQEKEKQKTEDFKTEQEKSTKDTMSTESISKGEEAMPSEESMMDSGKTLAEISDRYGAPNLSRVEELDEPMLSDILSNEPGVHLLARLSGR", "length": 183 }, "evidence": [ { "id": "Q32LH1", "url": "https://omabrowser.org/oma/group/Q32LH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y918-1", "protein_name": "DPY30 domain-containing protein 1", "gene_name": "DYDC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESQYLRRCLGSCLKKGLAEVVEHRPADPIEYLAHWIYHYKRSLDEEQKRTLERAELEKEQQAALEELEMLRKMKEEELMIQQRLEEQRQEEEREKLKLQNEEEKMQLQQKDPEENEKTIAEITDRAGAPNLTTVEELDESGVSEIATDLMPEFEQETSISPDYDSND", "length": 168 }, "evidence": [ { "id": "Q32LH1", "url": "https://omabrowser.org/oma/group/Q32LH1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8WWB3-1", "protein_name": "DPY30 domain-containing protein 1", "gene_name": "DYDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESIYLQKHLGACLTQGLAEVARVRPVDPIEYLALWIYKYKENVTMEQLRQKEMAKLERERELALMEQEMMERLKAEELLLQQQQLALQLELEMQEKERQRIQELQRAQEQLGKEMRMNMENLVRNEDILHSEEATLDSGKTLAEISDRYGAPNLSRVEELDEPMFSDIALNIDQDL", "length": 177 }, "evidence": [ { "id": "Q32LH1", "url": "https://omabrowser.org/oma/group/Q32LH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9T0-1", "protein_name": "DPY30 domain-containing protein 1", "gene_name": "Dydc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESRYLQKCLGTCLTQGLTEVARVRPLDPIEYLAFWLYKHKENMNMEQMRQREMITLEHERELAMMEQEMLERLKAEELLFQQQLAFQLELEMQQKEKQKSEDFETGQEKSFKSMMSMESTARGEEQEPMQAEELVMDSGKTLAEISDRYGAPNLSRVEELDEPMLSDNGVSAPP", "length": 175 }, "evidence": [ { "id": "Q32LH1", "url": "https://omabrowser.org/oma/group/Q32LH1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "radial spoke", "id": "GO:0001534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001534", "evidence": [ { "database": "UniProtKB", "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1" } ], "pmid": "" }, { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "Q32LH1", "url": "https://www.uniprot.org/uniprotkb/Q32LH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LH1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 175, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LH1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LH1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBN7-1", "uniprot_ac": "Q2TBN7", "uniprot_id": "MED27_BOVIN", "mass": { "chemical_mass": 35373.0, "monoisotopic_mass": 35373.0 }, "refseq": { "ac": "NP_001035636", "name": "mediator of RNA polymerase II transcription subunit 27", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" }, "gene_names": [ { "name": "MED27", "type": "recommended", "evidence": [ { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ] }, { "name": "CRSP8", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" }, { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ] }, { "name": "MED27", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 27", "type": "recommended", "evidence": [ { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#names_and_taxonomy" } ] }, { "name": "CRSP complex subunit 8", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" }, { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#names_and_taxonomy" } ] }, { "name": "Cofactor required for Sp1 transcriptional activation subunit 8", "type": "synonym", "evidence": [ { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 27", "type": "synonym", "evidence": [ { "id": "Q2TBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#names_and_taxonomy" } ] }, { "name": "cofactor required for Sp1 transcriptional activation subunit 8", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" } ] }, { "name": "cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 27", "type": "synonym", "evidence": [ { "id": "NP_001035636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED27", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7", "locus": { "chromosome": "11", "start_pos": 101923137, "end_pos": 102165145, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000382", "url": "https://www.ensembl.org/id/ENSBTAG00000000382" } ] } } ], "crossref": [ { "id": "Q2TBN7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525389", "url": "https://www.ncbi.nlm.nih.gov/gene/525389", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525389", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525389", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FHEDCRN", "url": "https://omabrowser.org/oma/group/FHEDCRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBN7", "url": "https://www.orthodb.org/?gene=Q2TBN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13130:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13130:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9841922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035636", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SA78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBN7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311, "header": "sp|Q2TBN7-1|MED27_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=2 SV=1 CANONICAL=Q2TBN7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA78-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#A0AAA9SA78-1", "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 275, "header": "tr|A0AAA9SA78-1|A0AAA9SA78_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=3 SV=1 CANONICAL=Q2TBN7-1" }, "locus": { "chromosome": "11", "start_pos": 102165119, "end_pos": 101946602, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099713.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099713.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082229.1" } ] } }, { "isoform_ac": "A0AAA9TS20-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#A0AAA9TS20-1", "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 297, "header": "tr|A0AAA9TS20-1|A0AAA9TS20_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=3 SV=1 CANONICAL=Q2TBN7-1" }, "locus": { "chromosome": "11", "start_pos": 102165119, "end_pos": 101946602, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087951.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087951.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101175.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101175.1" } ] } }, { "isoform_ac": "A0AAA9TY95-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#A0AAA9TY95-1", "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMRTKYPRRAEAATQELKV", "length": 284, "header": "tr|A0AAA9TY95-1|A0AAA9TY95_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=3 SV=1 CANONICAL=Q2TBN7-1" }, "locus": { "chromosome": "11", "start_pos": 102165119, "end_pos": 101923802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107920.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107920.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102479.1" } ] } }, { "isoform_ac": "A0AAF6YGV8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#A0AAF6YGV8-1", "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKETHAVEPIRCHRRPVSMPSVLPPTCVFVAPIGKAKGAPLTSEGLRG", "length": 287, "header": "tr|A0AAF6YGV8-1|A0AAF6YGV8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=3 SV=1 CANONICAL=Q2TBN7-1" }, "locus": { "chromosome": "11", "start_pos": 102165119, "end_pos": 101959381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000493.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000493.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000493.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000493.4" } ] } }, { "isoform_ac": "Q2TBN7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7/entry#Q2TBN7-1", "sequence": { "sequence": "MADVLSVGVNLEAFAQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMTIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311, "header": "sp|Q2TBN7-1|MED27_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus OX=9913 GN=MED27 PE=2 SV=1 CANONICAL=Q2TBN7-1" }, "locus": { "chromosome": "11", "start_pos": 102165119, "end_pos": 101946602, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100749.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100749.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075882.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "site_lbl": "Ser132" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525389", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525389", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9841922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "resource": "Reactome", "description": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RZ56-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "Med27", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAVLLVTLGKVLKVIVVMRSLFIDRTIVKGYNESVYTEDGKLDIWSKSSYQVFQKVSVPLCLIQLSSIPEGDRPCHHCPASLSVTPDARRCGQVLHDLVEKLH", "length": 289 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I9P4-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "Med27", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6P2C8-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "MED27", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PFL0-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "med27", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADVMNVGVNLEAFSQAINAIQALRSSVTRVFDFLKDGMKNKETLESREKVFITEFQENLQSVNRDLNELERLSTLVGRPSESHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASSLLNQQSLKRSANQMGTSAKRRPKVQPSTLALPTQYVDDVISRIGRMFPDMSIELFRPNGTSAVLLVTLGKVLKAIVVMRSLFIDRTIVRGFHENIYTEDRKLDIWSKSNYQAFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQTPCQRCGKYLQEGLPPTWRDFRTLEAFHDTCRQ", "length": 311 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6Q7J5-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "MED27", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9DB40-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "Med27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIANFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNESVYTEDGKLDIWSKSSYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ", "length": 311 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VNG0-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "MED27", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDKLNSTLTAVKNLRSNVRLCFEHLADGTDGESGEESRNKFVNDFQERFAAINSQIREVEQLINGLPVPPTPYSLGNTAYLAQETSQDRQALYPQLVNSYKWMDKVHDHSFLAFNNLNQNTLRRSYNYCSQKRQRLPFSSFNNDPDHIDKLLSEINTPPHTSYRIFRPFGTNAVTIVTISNVMKAAIVFKGVLIEWVTVKGFDEPLEHDDLWAESRYEVFRKVQDHAHSAMLHFFSPTLPDLAVKSYITWLNSHVKLFLEPCKRCGKFVVNGLPPTWRDLRTLEPFHEDCRNC", "length": 293 }, "evidence": [ { "id": "Q2TBN7", "url": "https://omabrowser.org/oma/group/Q2TBN7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN7", "url": "https://www.uniprot.org/uniprotkb/Q2TBN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBN7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBN7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBN7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 132 ], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBG7-1", "uniprot_ac": "Q3ZBG7", "uniprot_id": "SRP19_BOVIN", "mass": { "chemical_mass": 16140.0, "monoisotopic_mass": 16140.0 }, "refseq": { "ac": "NP_001029650", "name": "signal recognition particle 19 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029650" }, "gene_names": [ { "name": "SRP19", "type": "recommended", "evidence": [ { "id": "Q3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ] }, { "name": "SRP19", "type": "synonym", "evidence": [ { "id": "NP_001029650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029650" } ] } ], "protein_names": [ { "name": "Signal recognition particle 19 kDa protein", "type": "recommended", "evidence": [ { "id": "Q3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#names_and_taxonomy" } ] }, { "name": "SRP19", "type": "synonym", "evidence": [ { "id": "Q3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#names_and_taxonomy" } ] }, { "name": "signal recognition particle 19 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001029650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029650" } ] }, { "name": "signal recognition particle 19kDa", "type": "synonym", "evidence": [ { "id": "NP_001029650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029650" } ] } ], "function": [ { "annotation": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7#function" }, { "database": "UniProtKB", "id": "J9PAS6", "url": "https://www.uniprot.org/uniprotkb/J9PAS6#function" }, { "database": "UniProtKB", "id": "A0AAA9TNG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG3#function" }, { "database": "UniProtKB", "id": "ARBA00045518", "url": "https://www.uniprot.org/uniprotkb/ARBA00045518#function" }, { "database": "UniProtKB", "id": "A0AAA9SRT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRP19", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7", "locus": { "chromosome": "10", "start_pos": 1153150, "end_pos": 1161353, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012803", "url": "https://www.ensembl.org/id/ENSBTAG00000012803" } ] } } ], "crossref": [ { "id": "Q3ZBG7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514960", "url": "https://www.ncbi.nlm.nih.gov/gene/514960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QMERWIC", "url": "https://omabrowser.org/oma/group/QMERWIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBG7", "url": "https://www.orthodb.org/?gene=Q3ZBG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17453:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17453:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01922", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01922", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBG7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCAAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK", "length": 144, "header": "sp|Q3ZBG7-1|SRP19_BOVIN Isoform 1 of Signal recognition particle 19 kDa protein OS=Bos taurus OX=9913 GN=SRP19 PE=2 SV=1 CANONICAL=Q3ZBG7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD58-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#A0AAA9SD58-1", "sequence": { "sequence": "MACAAARSPADQDRLLKILQLQRFKMYVQQLDLMYFLRKIKCTLENGIVIFSTGAESGSSSNRKMAASVLYSSHHVSQ", "length": 78, "header": "tr|A0AAA9SD58-1|A0AAA9SD58_BOVIN Computationally mapped isoform of Signal recognition particle 19 OS=Bos taurus OX=9913 GN=SRP19 PE=4 SV=1 CANONICAL=Q3ZBG7-1" }, "locus": { "chromosome": "10", "start_pos": 1161172, "end_pos": 1153633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109019.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109019.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080259.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080259.1" } ] } }, { "isoform_ac": "A0AAA9SRT7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#A0AAA9SRT7-1", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCAAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSLYVLSLTSGS", "length": 110, "header": "tr|A0AAA9SRT7-1|A0AAA9SRT7_BOVIN Computationally mapped isoform of Signal recognition particle 19 kDa protein OS=Bos taurus OX=9913 GN=SRP19 PE=3 SV=1 CANONICAL=Q3ZBG7-1" }, "locus": { "chromosome": "10", "start_pos": 1161172, "end_pos": 1153645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126061.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126061.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086788.1" } ] } }, { "isoform_ac": "A0AAA9TNG3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#A0AAA9TNG3-1", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK", "length": 120, "header": "tr|A0AAA9TNG3-1|A0AAA9TNG3_BOVIN Computationally mapped isoform of Signal recognition particle 19 kDa protein OS=Bos taurus OX=9913 GN=SRP19 PE=3 SV=1 CANONICAL=Q3ZBG7-1" }, "locus": { "chromosome": "10", "start_pos": 1161172, "end_pos": 1153511, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108500.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108500.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098558.1" } ] } }, { "isoform_ac": "Q3ZBG7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7/entry#Q3ZBG7-1", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCAAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK", "length": 144, "header": "sp|Q3ZBG7-1|SRP19_BOVIN Isoform 1 of Signal recognition particle 19 kDa protein OS=Bos taurus OX=9913 GN=SRP19 PE=2 SV=1 CANONICAL=Q3ZBG7-1" }, "locus": { "chromosome": "10", "start_pos": 1161172, "end_pos": 1153511, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017007.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017007.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017007.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017007.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514960", "resource": "KEGG Pathway" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y1Z1-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "SRP19", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAAAASPADKERFICIYPAYLNNKKTIAEGRRIPIDKAVENPTSTEIQDVCAAVGFNVLLEKNKMYPREWNRDVQYRGRVRIQLKQDDGNPCLPQFPTRKSVMLYAAETIPKLKTRTQKMGGSDQSLQQGEGGKKDGHIT", "length": 142 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RZ66-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "Srp19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPINKAVENPTATEIQDVCSAVGLNAFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYVAEMIPKLKTRTQKSGGADPSLQQGEGSKKGKGKKKK", "length": 144 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RLG4-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "SRP19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK", "length": 144 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P09132-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "SRP19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK", "length": 144 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49963-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "Srp19", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATAVPMKKNWSPSMKHNDMERWICIYPAYINRKKTRQEGRRLPKENCVDNPSYIEIRDVLSVSNLQFLMENKKYCRENSSEMEFRGRVRVQLRNVDGTLYNNDFPTRESIMLHIASKIPQLKTRQNKSGDSYHQQSQPQSNASGSGGGGGGKKGKGKRR", "length": 160 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q943Z6-1", "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "SRP19", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSGTINIKKWVVIYPVYINSKKTVAEGRRISVSKSCENPNCIEISDCCKHLKLPSAVEIDKAYPRDFMQVGRVRVQLKREDGTLLNPAITSRKHLMQKIAELVPRHPERVKKQEAQKAKKQEPQATTSTSGTSSKSGKGGKKKR", "length": 145 }, "evidence": [ { "id": "Q3ZBG7", "url": "https://omabrowser.org/oma/group/Q3ZBG7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "signal recognition particle, endoplasmic reticulum targeting", "id": "GO:0005786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005786", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" }, { "name": "7S RNA binding", "id": "GO:0008312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008312", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "id": "GO:0006617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006617", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" }, { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBG7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBL9-1", "uniprot_ac": "Q2TBL9", "uniprot_id": "TPPC4_BOVIN", "mass": { "chemical_mass": 24264.0, "monoisotopic_mass": 24264.0 }, "refseq": { "ac": "NP_001178133", "name": "trafficking protein particle complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178133" }, "gene_names": [ { "name": "TRAPPC4", "type": "recommended", "evidence": [ { "id": "Q2TBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ] }, { "name": "TRAPPC4", "type": "synonym", "evidence": [ { "id": "NP_001178133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178133" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 4", "type": "recommended", "evidence": [ { "id": "Q2TBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9/entry#names_and_taxonomy" } ] }, { "name": "trafficking protein particle complex 4", "type": "synonym", "evidence": [ { "id": "NP_001178133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178133" } ] }, { "name": "trafficking protein particle complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001178133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178133" } ] } ], "function": [ { "annotation": "Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9#function" }, { "database": "UniProtKB", "id": "Q9Y296", "url": "https://www.uniprot.org/uniprotkb/Q9Y296#function" }, { "database": "UniProtKB", "id": "Q9ES56", "url": "https://www.uniprot.org/uniprotkb/Q9ES56#function" }, { "database": "UniProtKB", "id": "A0AAA9SED5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED5#function" }, { "database": "UniProtKB", "id": "ARBA00046052", "url": "https://www.uniprot.org/uniprotkb/ARBA00046052#function" }, { "database": "UniProtKB", "id": "A0AAA9TG80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG80#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC4", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9", "locus": { "chromosome": "15", "start_pos": 29594196, "end_pos": 29590521, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008075", "url": "https://www.ensembl.org/id/ENSBTAG00000008075" } ] } } ], "crossref": [ { "id": "Q2TBL9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008075", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14856", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14856", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785345", "url": "https://www.ncbi.nlm.nih.gov/gene/785345", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785345", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785345", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQRDGIN", "url": "https://omabrowser.org/oma/group/GQRDGIN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBL9", "url": "https://www.orthodb.org/?gene=Q2TBL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23249:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23249:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04099", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04099", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178133", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SED5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SED5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBL9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGVDVNGKYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219, "header": "sp|Q2TBL9-1|TPPC4_BOVIN Isoform 1 of Trafficking protein particle complex subunit 4 OS=Bos taurus OX=9913 GN=TRAPPC4 PE=2 SV=1 CANONICAL=Q2TBL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SED5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9/entry#A0AAA9SED5-1", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 126, "header": "tr|A0AAA9SED5-1|A0AAA9SED5_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit OS=Bos taurus OX=9913 GN=TRAPPC4 PE=3 SV=1 CANONICAL=Q2TBL9-1" }, "locus": { "chromosome": "15", "start_pos": 29593927, "end_pos": 29590868, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097887.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097887.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081946.1" } ] } }, { "isoform_ac": "A0AAA9TG80-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9/entry#A0AAA9TG80-1", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGVDVNGKYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSSETCDGSGWRKALTKVGSGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 203, "header": "tr|A0AAA9TG80-1|A0AAA9TG80_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit OS=Bos taurus OX=9913 GN=TRAPPC4 PE=3 SV=1 CANONICAL=Q2TBL9-1" }, "locus": { "chromosome": "15", "start_pos": 29593927, "end_pos": 29590868, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095869.1" } ] } }, { "isoform_ac": "Q2TBL9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9/entry#Q2TBL9-1", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGVDVNGKYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219, "header": "sp|Q2TBL9-1|TPPC4_BOVIN Isoform 1 of Trafficking protein particle complex subunit 4 OS=Bos taurus OX=9913 GN=TRAPPC4 PE=2 SV=1 CANONICAL=Q2TBL9-1" }, "locus": { "chromosome": "15", "start_pos": 29593927, "end_pos": 29590868, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010619.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010619.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010619.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010619.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785345", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785345", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I977-1", "protein_name": "Trafficking protein particle complex subunit", "gene_name": "Trappc4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQWDSYSPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGKYTADGKEVLEYLGNSANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219 }, "evidence": [ { "id": "Q2TBL9", "url": "https://omabrowser.org/oma/group/Q2TBL9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q69BT7-1", "protein_name": "Trafficking protein particle complex subunit 4", "gene_name": "Trappc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQWDSYSPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGKYTADGKEVLEYPGNSANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219 }, "evidence": [ { "id": "Q2TBL9", "url": "https://omabrowser.org/oma/group/Q2TBL9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ES56-1", "protein_name": "Trafficking protein particle complex subunit 4", "gene_name": "Trappc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQWDSYSPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGKYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219 }, "evidence": [ { "id": "Q2TBL9", "url": "https://omabrowser.org/oma/group/Q2TBL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VLI9-1", "protein_name": "Trafficking protein particle complex subunit", "gene_name": "Trs23", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIIYGVYIVSKSGGLIFNLDNNVPRIEHEKTFTYPLDLVLDYDSKKVSVSFNRKDGINVGHVLVAVNGMPVNGVTLDDGRDVRTTLDAPENYPINLKFSRPKMTTNEKIFLASMFYPLFAIASQLSPEPKSSGIEILEADTFTLHCFQTLTGIKFIIISETGLNGIDLLLRKVYELYSDYVLKNPFYSLEMPIRCELFDNKLQELLAQVEKTGISNIDK", "length": 219 }, "evidence": [ { "id": "Q2TBL9", "url": "https://omabrowser.org/oma/group/Q2TBL9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y296-1", "protein_name": "Trafficking protein particle complex subunit 4", "gene_name": "TRAPPC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS", "length": 219 }, "evidence": [ { "id": "Q2TBL9", "url": "https://omabrowser.org/oma/group/Q2TBL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "presynaptic active zone", "id": "GO:0048786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048786", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dendrite development", "id": "GO:0016358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL9", "url": "https://www.uniprot.org/uniprotkb/Q2TBL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL16-1", "uniprot_ac": "Q2NL16", "uniprot_id": "FBX28_BOVIN", "mass": { "chemical_mass": 41096.0, "monoisotopic_mass": 41096.0 }, "refseq": { "ac": "NP_001039890", "name": "F-box only protein 28", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039890" }, "gene_names": [ { "name": "FBXO28", "type": "recommended", "evidence": [ { "id": "Q2NL16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ] }, { "name": "FBXO28", "type": "synonym", "evidence": [ { "id": "NP_001039890", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039890" } ] } ], "protein_names": [ { "name": "F-box only protein 28", "type": "recommended", "evidence": [ { "id": "Q2NL16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL16/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 28", "type": "synonym", "evidence": [ { "id": "NP_001039890", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039890" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of specific target proteins including TOP2A, RAB27A or itself. Regulates topoisomerase IIalpha/TOP2A decatenation activity and plays an important role in maintaining genomic stability (By similarity). Plays a role in lipid metabolism and inflammation through the ubiquitinated degradation of RAB27A (By similarity). Strongly regulates beta-cell survival without having any significant independent effect on insulin secretion (By similarity). Plays an essential role in spindle morphology and actin-based spindle migration probably through the ARPC2/ARP3 signaling pathway (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16#function" }, { "database": "UniProtKB", "id": "Q9NVF7", "url": "https://www.uniprot.org/uniprotkb/Q9NVF7#function" }, { "database": "UniProtKB", "id": "Q8BIG4", "url": "https://www.uniprot.org/uniprotkb/Q8BIG4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO28", "url": "https://www.uniprot.org/uniprotkb/Q2NL16", "locus": { "chromosome": "16", "start_pos": 27331318, "end_pos": 27306978, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019538", "url": "https://www.ensembl.org/id/ENSBTAG00000019538" } ] } } ], "crossref": [ { "id": "Q2NL16", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019538", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019538", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22100", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22100", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537745", "url": "https://www.ncbi.nlm.nih.gov/gene/537745", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537745", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537745", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSHFPRC", "url": "https://omabrowser.org/oma/group/SSHFPRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL16", "url": "https://www.orthodb.org/?gene=Q2NL16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13252:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13252:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039890", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P156", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P156", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P156-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P156-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL16-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSPSAIASTQRLPPPPPPQPPQPGSQAPPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQSEESPRKRKKAAEAIDSLRKSKRLRNRK", "length": 368, "header": "sp|Q2NL16-1|FBX28_BOVIN Isoform 1 of F-box only protein 28 OS=Bos taurus OX=9913 GN=FBXO28 PE=2 SV=1 CANONICAL=Q2NL16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEH4-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL16/entry#A0AAA9SEH4-1", "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSPSAIASTQRLPPPPPPQPPQPGSQAPPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKFQDRLQP", "length": 179, "header": "tr|A0AAA9SEH4-1|A0AAA9SEH4_BOVIN Computationally mapped isoform of F-box protein 28 OS=Bos taurus OX=9913 GN=FBXO28 PE=4 SV=1 CANONICAL=Q2NL16-1" }, "locus": { "chromosome": "16", "start_pos": 27330314, "end_pos": 27307018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082248.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082248.1" } ] } }, { "isoform_ac": "A0ABI0P156-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL16/entry#A0ABI0P156-1", "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSPSAIASTQRLPPPPPPQPPQPGSQAPPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLISKLTCKFHSTSFNGCFFFFFDRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQSEESPRKRKKAAEAIDSLRKSKRLRNRK", "length": 354, "header": "tr|A0ABI0P156-1|A0ABI0P156_BOVIN Computationally mapped isoform of F-box protein 28 OS=Bos taurus OX=9913 GN=FBXO28 PE=4 SV=1 CANONICAL=Q2NL16-1" }, "locus": { "chromosome": "16", "start_pos": 27330685, "end_pos": 27307018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151189.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151189.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106381.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106381.1" } ] } }, { "isoform_ac": "Q2NL16-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL16/entry#Q2NL16-1", "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSPSAIASTQRLPPPPPPQPPQPGSQAPPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQSEESPRKRKKAAEAIDSLRKSKRLRNRK", "length": 368, "header": "sp|Q2NL16-1|FBX28_BOVIN Isoform 1 of F-box only protein 28 OS=Bos taurus OX=9913 GN=FBXO28 PE=2 SV=1 CANONICAL=Q2NL16-1" }, "locus": { "chromosome": "16", "start_pos": 27330685, "end_pos": 27307018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141825.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141825.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104169.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "site_lbl": "Ser235" }, { "start_pos": 242, "end_pos": 242, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "site_lbl": "Ser242" }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "site_lbl": "Thr270" }, { "start_pos": 344, "end_pos": 344, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "site_lbl": "Ser344" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537745", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537745", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z3H2-1", "protein_name": "F-box protein 28", "gene_name": "FBXO28", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAEERLLSEGEGGAPGSARLSPPPLSQSPEAPAPLEQPPQSNTLMGLPIVAIESILSFLSYDETSQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLIGAAPGILIKTTFPSSNSSMILGLRKNEYTSSWKINPLLLKIPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKANGAGVTVLKREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGSSSGSGSNEQSPRKRRKAVESTDCPRKSKRLRNRK", "length": 386 }, "evidence": [ { "id": "Q2NL16", "url": "https://omabrowser.org/oma/group/Q2NL16/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RZ28-1", "protein_name": "F-box protein 28", "gene_name": "Fbxo28", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSCSAASSAQRQPPTPPSQALQPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK", "length": 368 }, "evidence": [ { "id": "Q2NL16", "url": "https://omabrowser.org/oma/group/Q2NL16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BIG4-1", "protein_name": "F-box only protein 28", "gene_name": "Fbxo28", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVRTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK", "length": 368 }, "evidence": [ { "id": "Q2NL16", "url": "https://omabrowser.org/oma/group/Q2NL16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVF7-1", "protein_name": "F-box only protein 28", "gene_name": "FBXO28", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAEERMAEEGGGGQGDGGSSLASGSTQRQPPPPAPQHPQPGSQALPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAIDSLRKSKRLRNRK", "length": 368 }, "evidence": [ { "id": "Q2NL16", "url": "https://omabrowser.org/oma/group/Q2NL16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "Q2NL16", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 368, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL16-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL16" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NL16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL16" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 61, "end_pos": 109, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 235, 242, 270, 344 ], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL24-1", "uniprot_ac": "Q2NL24", "uniprot_id": "PSMG2_BOVIN", "mass": { "chemical_mass": 29224.0, "monoisotopic_mass": 29224.0 }, "refseq": { "ac": "NP_001039830", "name": "proteasome assembly chaperone 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039830" }, "gene_names": [ { "name": "PSMG2", "type": "recommended", "evidence": [ { "id": "Q2NL24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ] }, { "name": "PSMG2", "type": "synonym", "evidence": [ { "id": "NP_001039830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039830" } ] } ], "protein_names": [ { "name": "Proteasome assembly chaperone 2", "type": "recommended", "evidence": [ { "id": "Q2NL24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL24/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) assembly chaperone 2", "type": "synonym", "evidence": [ { "id": "NP_001039830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039830" } ] }, { "name": "proteasome assembly chaperone 2", "type": "synonym", "evidence": [ { "id": "NP_001039830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039830" } ] } ], "function": [ { "annotation": "Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24#function" }, { "database": "UniProtKB", "id": "Q969U7", "url": "https://www.uniprot.org/uniprotkb/Q969U7#function" }, { "database": "UniProtKB", "id": "A0AAA9SUD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUD8#function" }, { "database": "UniProtKB", "id": "ARBA00054951", "url": "https://www.uniprot.org/uniprotkb/ARBA00054951#function" }, { "database": "UniProtKB", "id": "A0ABI0NQ01", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ01#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMG2", "url": "https://www.uniprot.org/uniprotkb/Q2NL24", "locus": { "chromosome": "24", "start_pos": 43082953, "end_pos": 43072557, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010552", "url": "https://www.ensembl.org/id/ENSBTAG00000010552" } ] } } ], "crossref": [ { "id": "Q2NL24", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010552", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010552", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533993", "url": "https://www.ncbi.nlm.nih.gov/gene/533993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038389", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038389", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKEHTGE", "url": "https://omabrowser.org/oma/group/WKEHTGE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL24", "url": "https://www.orthodb.org/?gene=Q2NL24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12970", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12970", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12970:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12970:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039830", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ01", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ01-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL24-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFVPSGDSVPDLAGCTLLMPAVSVGNVGQLAIDLIISTLNMHKIGYFYTDCLVPMVGNNPYATAEENSAELSINAEVYALPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKCSGCAKVVVLSSSHSYHRNDLQLRSTPFRYLLTPSMQKSVQNKIQSLNWEEMEKTPCIPEIDDSEFCVRVPGGGITKLLYDEGCSKEIPIAILLKFVSEGDNIPDALGLVEYLNEWLQIIKPHCEDPTASSLPWKMPSSWRLLFGSGLPPALF", "length": 264, "header": "sp|Q2NL24-1|PSMG2_BOVIN Isoform 1 of Proteasome assembly chaperone 2 OS=Bos taurus OX=9913 GN=PSMG2 PE=2 SV=1 CANONICAL=Q2NL24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL24/entry#A0AAA9SGY7-1", "sequence": { "sequence": "AASARTPFPAAATCWAPPRSRRRPQRLRGGARARDRWPRALPGPPRQAGGGTGRLQLLFPNGGWAVPAPPVSHLGWRPCSAPPADSAPCPPARSHAPPRPPPPPAAPPARRPGRQWDGHLRTATRASKDPRSPPPALPAAGSSCRQRNHVRPLRGLGPRPRGVHPPNVYALPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKCSGCAKVVVLSSSHSYHRNDLQLRSTPFRYLLTPSMQKSVQNKIQSLNWEEMEKTPCIPEIDDSEFCVRVPGGGITKLLYDEGCSKEIPIAILLKFVSEGDNIPDALGLVEYLNEWLQIIKPHCEDPTASSLPWKMPSSWRLLFGSGLPPALF", "length": 355, "header": "tr|A0AAA9SGY7-1|A0AAA9SGY7_BOVIN Computationally mapped isoform of Proteasome assembly chaperone 2 OS=Bos taurus OX=9913 GN=PSMG2 PE=3 SV=1 CANONICAL=Q2NL24-1" }, "locus": { "chromosome": "24", "start_pos": 43082788, "end_pos": 43072582, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090996.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090996.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082959.1" } ] } }, { "isoform_ac": "A0AAA9SUD8-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL24/entry#A0AAA9SUD8-1", "sequence": { "sequence": "MFVPSGDSVPDLAGCTLLMVTSSTLDGEEGSHIGLKKWEKTWRCPAVSVGNVGQLAIDLIISTLNMHKIGYFYTDCLVPMVGNNPYATAEENSAELSINAEVYALPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKCSGCAKVVVLSSSHSYHRNDLQLRSTPFRYLLTPSMQKSVQNKIQSLNWEEMEKTPCIPEIDDSEFCVRVPGGGITKLLYDEGCSKEIPIAILLKFVSEGDNIPDALGLVEYLNEWLQIIKPHCEDPTASSLPWKMPSSWRLLFGSGLPPALF", "length": 289, "header": "tr|A0AAA9SUD8-1|A0AAA9SUD8_BOVIN Computationally mapped isoform of Proteasome assembly chaperone 2 OS=Bos taurus OX=9913 GN=PSMG2 PE=3 SV=1 CANONICAL=Q2NL24-1" }, "locus": { "chromosome": "24", "start_pos": 43082788, "end_pos": 43073027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106094.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106094.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088950.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088950.1" } ] } }, { "isoform_ac": "A0ABI0NQ01-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL24/entry#A0ABI0NQ01-1", "sequence": { "sequence": "MPAVSVGNVGQLAIDLIISTLNMHKIGYFYTDCLVPMVGNNPYATAEENSAELSINAEVYALPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKCSGCAKVVVLSSSHSYHRNDLQLRSTPFRYLLTPSMQKSVQNKIQSLNWEEMEKTPCIPEIDDSEFCVRVPGGGITKLLYDEGCSKEIPIAILLKFVSEGDNIPDALGLVEYLNEWLQIIKPHCEDPTASSLPWKMPSSWRLLFGSGLPPALF", "length": 246, "header": "tr|A0ABI0NQ01-1|A0ABI0NQ01_BOVIN Computationally mapped isoform of Proteasome assembly chaperone 2 OS=Bos taurus OX=9913 GN=PSMG2 PE=3 SV=1 CANONICAL=Q2NL24-1" }, "locus": { "chromosome": "24", "start_pos": 43082788, "end_pos": 43073395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147862.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147862.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104147.1" } ] } }, { "isoform_ac": "Q2NL24-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL24/entry#Q2NL24-1", "sequence": { "sequence": "MFVPSGDSVPDLAGCTLLMPAVSVGNVGQLAIDLIISTLNMHKIGYFYTDCLVPMVGNNPYATAEENSAELSINAEVYALPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKCSGCAKVVVLSSSHSYHRNDLQLRSTPFRYLLTPSMQKSVQNKIQSLNWEEMEKTPCIPEIDDSEFCVRVPGGGITKLLYDEGCSKEIPIAILLKFVSEGDNIPDALGLVEYLNEWLQIIKPHCEDPTASSLPWKMPSSWRLLFGSGLPPALF", "length": 264, "header": "sp|Q2NL24-1|PSMG2_BOVIN Isoform 1 of Proteasome assembly chaperone 2 OS=Bos taurus OX=9913 GN=PSMG2 PE=2 SV=1 CANONICAL=Q2NL24-1" }, "locus": { "chromosome": "24", "start_pos": 43082788, "end_pos": 43073027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013953.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013953.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013953.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013953.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 137, "end_pos": 137, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "site_lbl": "Thr137" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533993", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533993", "resource": "KEGG Pathway" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZXX4-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "PSMG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFVPCGDSVPDLAGCTLLMPAVSVGNVGQLAIDLIISTLNMCKIGYFYTDCLVPMVGNNPYATAEENSTELSINAEVYASPSKKLVALQLRSIFIKYKSKSFCEKLLSWVKSSDLAKVVVLSSSHSYQRNDLQLRSTPFRYLLTPSIPKSVQNKIQSLNWEEMEKSPCIPEIDDSEFCVRVPGGGITKTLYDEGCSKGIPMAVLLKFVSEGDNIPDALGLVEYLNEWLQIIKPCCEDTTESALPWKMPSSWRLLFGSGLPPALF", "length": 264 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0X9V0-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "PSMG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFVPCDGGGLDFEGFTLLMPAVSVGNVGQLAVDLVISTLRMPKVGYFYTDCLVPMVGNNPYATTKENSMELSINAEVYSLPSKKLVVLQIRSPFIKNKYRPFCQTLLSWVESSKCARVILLSSSHAYQRDDEQLLGTPLRYLLTPALEKTVEGHIQELKWKEMEKVAAYPGISDAEKVLHIPGGGITKLLFTESCSKGIHMAVLLKFCSEGDNIPDAFGLVNYLNEWLQLIKIRVSAVCFRAFIFYYQLFSFSVLAGFALACGHQEQSKRKICFG", "length": 275 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JG55-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "Psmg2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFIPCGESIPDLTNFTLLMPAVSVGNVGQLAIDLIISTLDMSKIGYFYTDCLVPMVGNNPYATEEEDSEELSINTEVYALPSKKLVVLQLRSIFIKYKSKSFCEKLLAWVKSSCCARIIVLSSSHSYQRNDMQLRSTPFRYLLTPSMQKSVQNKIKSLNWLEMEKSPCIPEISDSEICIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDAISLVEYLNEWIQILKPSSDRHTSALPWKIPSSWQLLFGSGLPPALF", "length": 263 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1LXS2-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "psmg2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFISSGDAVPSFKGFTLILPAVSVGNVGQLAVDLLISTLNMPRVGYFHTDCLIPMAGNNPYASSTEDAAQLSTSAEVYSHRDLKLAVLQIRAPIIQTKVKSFRKLMISWMKSSGFLRTVLLSSAHAYQRDDQQLHGTPLRYMLSPSLEKEERQRFEELGWREMEKISVFPGISDSEQRLYIPGGGVTKCLYTDCCTEDVPMAVVLIFCSEGDNIPDAFALINCLNDWLHLLEKPTQGSVQWRVPPSWKLLFGSGIPPLLF", "length": 260 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q869S8-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "psmG2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKFFYSIDNNNNNISFKNHTLIWPSLTLGNIGQLTIDVLICSFEFKRIGFIVDENITPIIGNDCFTTLDNNNGIMSTSIEVYQSSLFPSITLVQQRSPIVDGRIPNFSENLFKWINAEEIKEILFLSSSNANKRVDSQLTGSQVRFIKSDNVDKNIISKLNEMNISEMELTVQSPEGETIQLSNRLTGLAKEIYSTINSKNNDNNNKVSFLCLNLFCSEGYNTNEALQMSNLIYNFIKNQESPSSPQLKTPSCWKLLQGPTFDQSLFF", "length": 269 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q969U7-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "PSMG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIVLSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTVSASRWKIPSSWRLLFGSGLPPALF", "length": 264 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EST4-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "Psmg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFVPCGESVPDLTNFTLLMPAVSVGNVGQLAIDLIISTLNMCKIGYFYTDCLVPMVGNNPYATEEENSNELSINTEVYSLPSKKLVVLQLRSIFIKYKSKSFCEKLLAWVESSGCARIIVLSSSHSYHRNDAQLRSTPFRYLLTPCLQKSVQNKIKSLNWLEMEKSRCIPEMSDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDAVSLVEYLNEWLQIIKPCNDGPMASALPWKIPSSWRLLFGSGLPPALF", "length": 264 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LJ72-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEFVVEEGKLVNEDCSTLVLPALSIGNVGQLAVDLLVSSTGAERVGYLDDPNLLPCVGNDAYGPLPCGEIALPLEVYESSSIATTLAQQRSPVAKGMMIKFAENIANFAASSGKKHIIVLSSLDFQRLHNLDMSRGPQVYYLSNAESDGRDDHCERLGFGRLHEYDSEGRCWKYLSSVFEKNSVEELALPSEDELEDIDYYPSLPFAALFSAFKARGLKMTCLLCYCSEGDNIPEAFLLAEASSKLMGLTPDKFHGEEGGKWQIPYSWKSMYGAPPDMSMF", "length": 281 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VEC2-1", "protein_name": "Proteasome assembly chaperone 2", "gene_name": "Dmel\\CG12321", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLFLKDKRTTLDVAEHTVIIPSICVGNAAQLACDLLIASKELRRIGSITHPALIPVYGPSAYQHEPKEKVSSCELYEGTEDKLLVVQFRAPWVARHTAHFQKELVELLKGARRVVILSGSFGFEKRVIEESPWAYRASENFKEAHAAQLGNEELIKWKEHKGDAIYGGGNALQLFKAFDEQKVPVMLLFRYLLEGDNSTDASLIVRELNELCEDFLQLRNGGDGSFKLTVPKSWNLLFGNDVTELLF", "length": 247 }, "evidence": [ { "id": "Q2NL24", "url": "https://omabrowser.org/oma/group/Q2NL24/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome assembly", "id": "GO:0043248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043248", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "pmid": "" }, { "name": "chaperone-mediated protein complex assembly", "id": "GO:0051131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051131", "evidence": [ { "database": "UniProtKB", "id": "Q2NL24", "url": "https://www.uniprot.org/uniprotkb/Q2NL24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL24-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL24" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 137 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL21-1", "uniprot_ac": "Q2NL21", "uniprot_id": "DJC11_BOVIN", "mass": { "chemical_mass": 63237.0, "monoisotopic_mass": 63237.0 }, "refseq": { "ac": "NP_001039458", "name": "dnaJ homolog subfamily C member 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039458" }, "gene_names": [ { "name": "DNAJC11", "type": "recommended", "evidence": [ { "id": "Q2NL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ] }, { "name": "DNAJC11", "type": "synonym", "evidence": [ { "id": "NP_001039458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039458" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 11", "type": "recommended", "evidence": [ { "id": "Q2NL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL21/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 11", "type": "synonym", "evidence": [ { "id": "NP_001039458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039458" } ] }, { "name": "dnaJ homolog subfamily C member 11", "type": "synonym", "evidence": [ { "id": "NP_001039458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039458" } ] } ], "function": [ { "annotation": "Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21#function" }, { "database": "UniProtKB", "id": "Q9NVH1", "url": "https://www.uniprot.org/uniprotkb/Q9NVH1#function" }, { "database": "UniProtKB", "id": "Q5U458", "url": "https://www.uniprot.org/uniprotkb/Q5U458#function" }, { "database": "UniProtKB", "id": "A0AAA9SH07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH07#function" }, { "database": "UniProtKB", "id": "ARBA00056707", "url": "https://www.uniprot.org/uniprotkb/ARBA00056707#function" }, { "database": "UniProtKB", "id": "A0AAA9SWG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWG1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC11", "url": "https://www.uniprot.org/uniprotkb/Q2NL21", "locus": { "chromosome": "16", "start_pos": 46777605, "end_pos": 46707282, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011217", "url": "https://www.ensembl.org/id/ENSBTAG00000011217" } ] } } ], "crossref": [ { "id": "Q2NL21", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011217", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011217", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508137", "url": "https://www.ncbi.nlm.nih.gov/gene/508137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508137", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508137", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QLDKHTM", "url": "https://omabrowser.org/oma/group/QLDKHTM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL21", "url": "https://www.orthodb.org/?gene=Q2NL21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44157:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44157:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039458", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SH07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL21-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASCEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGIDATDLFDRYEEEYEDVSGSGFPQIEINKMHISQSIEAPLTASDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTHCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGVQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSIGVPQGVSLKIKLNRASQTYFFPIHLTDQLLPSAVFYATAGPLVLYFALHRLVIRPYLRAQKEKELEKQRESTATDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSKKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMALDSEALRIPKQSHRIDTDG", "length": 559, "header": "sp|Q2NL21-1|DJC11_BOVIN Isoform 1 of DnaJ homolog subfamily C member 11 OS=Bos taurus OX=9913 GN=DNAJC11 PE=2 SV=1 CANONICAL=Q2NL21-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH07-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL21/entry#A0AAA9SH07-1", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASCEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGIDATDLFDRYEEEYEDVSGSGFPQIEINKMHISQSIELEFGAGDLQGPLFGLKLFRNLTPRCFVTTHCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGVQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSIGVPQGVSLKIKLNRASQTYFFPIHLTDQLLPSAVFYATAGPLVLYFALHRLVIRPYLRAQKEKELEKQRESTATDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSKKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMALDSEALRIPKQSHRIDTDG", "length": 518, "header": "tr|A0AAA9SH07-1|A0AAA9SH07_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 11 OS=Bos taurus OX=9913 GN=DNAJC11 PE=3 SV=1 CANONICAL=Q2NL21-1" }, "locus": { "chromosome": "16", "start_pos": 46776331, "end_pos": 46707307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108654.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108654.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085486.1" } ] } }, { "isoform_ac": "A0AAA9SWG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL21/entry#A0AAA9SWG1-1", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASCEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGIDATDLFDRYEEEYEDVSGSGFPQIEINKMHISQSIEAPLTASDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTHCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGVQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSIGVPQGVSLKIKELEKQRESTATDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSKKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMALDSEALRIPKQSHRIDTDG", "length": 507, "header": "tr|A0AAA9SWG1-1|A0AAA9SWG1_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 11 OS=Bos taurus OX=9913 GN=DNAJC11 PE=3 SV=1 CANONICAL=Q2NL21-1" }, "locus": { "chromosome": "16", "start_pos": 46776331, "end_pos": 46707307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116625.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116625.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089659.1" } ] } }, { "isoform_ac": "Q2NL21-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL21/entry#Q2NL21-1", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASCEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGIDATDLFDRYEEEYEDVSGSGFPQIEINKMHISQSIEAPLTASDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTHCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGVQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSIGVPQGVSLKIKLNRASQTYFFPIHLTDQLLPSAVFYATAGPLVLYFALHRLVIRPYLRAQKEKELEKQRESTATDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSKKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMALDSEALRIPKQSHRIDTDG", "length": 559, "header": "sp|Q2NL21-1|DJC11_BOVIN Isoform 1 of DnaJ homolog subfamily C member 11 OS=Bos taurus OX=9913 GN=DNAJC11 PE=2 SV=1 CANONICAL=Q2NL21-1" }, "locus": { "chromosome": "16", "start_pos": 46776331, "end_pos": 46707307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014899.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014899.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014899.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014899.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 204, "end_pos": 204, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "site_lbl": "Ser204" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508137", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508137", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RIJ5-1", "protein_name": "DnaJ homolog subfamily C member 11", "gene_name": "DNAJC11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEYERLQREREERRLQQRTNPKGTISVGIDATDLFDRYEEEYEDVSGSGFPQIEINKMHISQSIEAPLTASDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAVVSVGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAVFYATVGPLVLYFAMHRLVIKPYLRAQKEKELEKQRESTATDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVSDRSKRHERVKAIDVTVPLQCLVRDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMALDSEALRIPKQSHRIDTDG", "length": 559 }, "evidence": [ { "id": "Q2NL21", "url": "https://omabrowser.org/oma/group/Q2NL21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q39079-1", "protein_name": "Chaperone protein dnaJ 13", "gene_name": "ATJ13", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMGQEAAPTGPPNRELYALLNLSPEASDEEIRKAYRQWAQVYHPDKIQSPQMKEVATENFQRICEAYEILSDETKRLIYDLYGMEGLNSGLELGPRLSKADEIKEELERIKRRNEEAKKMAHFQPTGSILFNLSVPHFLVGDGIMRGMVMASQVQSQLSKDDAIAIGGNLAANEKSGGGVATAILRRQISPVSSIEFVASTGLQSLIGVQTTRQLTIHSTATINISKSLSDGSINLTNTWTRQLSETSSGNIELALGMRSAITVGWKKRDENVSAAGDFKIESGGLGASARYTRKLSSKSHGRIVGRIGSNALEIELGGGRQISEFSTVRMMYTVGLKGIFWKVELHRGSQKLIVPILLSAHLAPVFATGAFIVPTSLYFLLKKFVVKPYLLKREKQKALENMEKTWGQVGEARARAEKAQQLLQTVATRKKNRQVETDGLIVTKALYGDPKAIERRNEGVEGLDSGVIDVTVPMNFLVSDSGQLKLHEGVKKSGIMGFCDPCPGQPKQLYIAYTYHSQPFEVIVGDYEELSIPQEGQ", "length": 538 }, "evidence": [ { "id": "Q2NL21", "url": "https://omabrowser.org/oma/group/Q2NL21/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54PV9-1", "protein_name": "DnaJ homolog subfamily C member 11 homolog", "gene_name": "dnajc11", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKIDKDILKIFESKENEQFDEDQEKDEKKMNEVDFYSILNISRNATDDEIKIAFKKLAFTYHPDKQTNEELKKETQDIFTLITLAKDTLSDPKLRAIYDQFGLEGIEHSKAIVNKYKEVDKLLQALDRIQKENEEDKLIQSFSATGSQSISLAYHHEYRHFFFKTLKSEAQFDIKTQKYGSFEFVPSITRKKNLAWFGLETSYLYPITQNTELFLSNNYNEANEGSIQTIGLKSLLSANTYGSIHCAFFDSFQPARFGCLLTRQLSPTITAIFRGTLQKEFWQGSLTLKRIVQKRLFEITIDSSNLGGLSGSITRDIPISKKSRISFSVGGYGGGFPLYSAGQHGFTGAAIGFKRKITKVFDIDLSMHVNPSRYLYVIGLHHRYQSLEIPIPIYSDLSLSTSLLFFTLPAVTLSLLKYLVVKPLMKKKEQKKIMEKKEKYADQARKAKRKAEMDITLVKQLVENKVLKEKTKNGLIIQEAVYGKLDEKVDHSDPFSVEFPPTIDVTIPLQYLVEDSKLVLHGNNKKSDLLGFWDPRISEEKQLKVTYFFQNRLHRITVNDIDQLLIPLKSHLIQ", "length": 575 }, "evidence": [ { "id": "Q2NL21", "url": "https://omabrowser.org/oma/group/Q2NL21/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5U458-1", "protein_name": "DnaJ homolog subfamily C member 11", "gene_name": "Dnajc11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERKRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDATDLFDRYDEEYEDVSGSGFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSVNFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTCHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTIVEYGAERKISRHSVLGAAVSIGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAVFYATVGPLVVYLAVHRLIIRPYLRAQKEKELEKQRENTASDILQKKQEAEAAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKNEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKSLRVLYQFRGVLHQVMVPDSEALRIPKQSHRIDTDG", "length": 559 }, "evidence": [ { "id": "Q2NL21", "url": "https://omabrowser.org/oma/group/Q2NL21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVH1-1", "protein_name": "DnaJ homolog subfamily C member 11", "gene_name": "DNAJC11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDATDLFDRYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSVGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAMFYATVGPLVVYFAMHRLIIKPYLRAQKEKELEKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMVLDSEALRIPKQSHRIDTDG", "length": 559 }, "evidence": [ { "id": "Q2NL21", "url": "https://omabrowser.org/oma/group/Q2NL21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "SAM complex", "id": "GO:0001401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001401", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "pmid": "" }, { "name": "MICOS complex", "id": "GO:0061617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061617", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cristae formation", "id": "GO:0042407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042407", "evidence": [ { "database": "UniProtKB", "id": "Q2NL21", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 559, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL21" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL21" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 14, "end_pos": 82, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 204 ], "sequon_annotation_sites": [ { "start_pos": 230, "end_pos": 232 }, { "start_pos": 281, "end_pos": 283 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KP1-1", "uniprot_ac": "Q32KP1", "uniprot_id": "TSN31_BOVIN", "mass": { "chemical_mass": 22874.0, "monoisotopic_mass": 22874.0 }, "refseq": { "ac": "NP_001032684", "name": "tetraspanin-31", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032684" }, "gene_names": [ { "name": "TSPAN31", "type": "recommended", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1" } ] }, { "name": "TSPAN31", "type": "synonym", "evidence": [ { "id": "NP_001032684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032684" } ] } ], "protein_names": [ { "name": "Tetraspanin-31", "type": "recommended", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#names_and_taxonomy" } ] }, { "name": "Tspan-31", "type": "synonym", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-31", "type": "synonym", "evidence": [ { "id": "NP_001032684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032684" } ] }, { "name": "tspan-31", "type": "synonym", "evidence": [ { "id": "NP_001032684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032684" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KP1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN31", "url": "https://www.uniprot.org/uniprotkb/Q32KP1", "locus": { "chromosome": "5", "start_pos": 55716601, "end_pos": 55719489, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007158", "url": "https://www.ensembl.org/id/ENSBTAG00000007158" } ] } } ], "crossref": [ { "id": "Q32KP1", "url": "https://alphafold.ebi.ac.uk/entry/Q32KP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510619", "url": "https://www.ncbi.nlm.nih.gov/gene/510619", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510619", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510619", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CHAPCKA", "url": "https://omabrowser.org/oma/group/CHAPCKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KP1", "url": "https://www.orthodb.org/?gene=Q32KP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032684", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KP1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KP1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVCGGFACSKNALCALNVVYMLVGLLLIGVAAWAKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFGISCSCLAINLSKQTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLDQQDYAFCTAVCKSRSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 210, "header": "sp|Q32KP1-1|TSN31_BOVIN Isoform 1 of Tetraspanin-31 OS=Bos taurus OX=9913 GN=TSPAN31 PE=2 SV=1 CANONICAL=Q32KP1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJD8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#A0AAA9SJD8-1", "sequence": { "sequence": "MVCGGFACSKNALCALNVVYMLVGLLLIGVAAWAKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVCKSRSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 126, "header": "tr|A0AAA9SJD8-1|A0AAA9SJD8_BOVIN Computationally mapped isoform of Tetraspanin 31 OS=Bos taurus OX=9913 GN=TSPAN31 PE=4 SV=1 CANONICAL=Q32KP1-1" }, "locus": { "chromosome": "5", "start_pos": 55719220, "end_pos": 55717055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134576.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134576.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083923.1" } ] } }, { "isoform_ac": "A0AAA9SQX7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#A0AAA9SQX7-1", "sequence": { "sequence": "MVCGGFACSKNALCALNVVYMTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLDQQDYAFCTAVCKSRSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 127, "header": "tr|A0AAA9SQX7-1|A0AAA9SQX7_BOVIN Computationally mapped isoform of Tetraspanin 31 OS=Bos taurus OX=9913 GN=TSPAN31 PE=4 SV=1 CANONICAL=Q32KP1-1" }, "locus": { "chromosome": "5", "start_pos": 55719220, "end_pos": 55717055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121974.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121974.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086450.1" } ] } }, { "isoform_ac": "A0AAA9TA98-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#A0AAA9TA98-1", "sequence": { "sequence": "MVLVLLVGLLLIGVAAWAKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFGISCSCLAINLSKQTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLDQQDYAFCTAVCKSRSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 194, "header": "tr|A0AAA9TA98-1|A0AAA9TA98_BOVIN Computationally mapped isoform of Tetraspanin 31 OS=Bos taurus OX=9913 GN=TSPAN31 PE=4 SV=1 CANONICAL=Q32KP1-1" }, "locus": { "chromosome": "5", "start_pos": 55718768, "end_pos": 55717055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093801.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093801.1" } ] } }, { "isoform_ac": "Q32KP1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1/entry#Q32KP1-1", "sequence": { "sequence": "MVCGGFACSKNALCALNVVYMLVGLLLIGVAAWAKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFGISCSCLAINLSKQTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLDQQDYAFCTAVCKSRSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 210, "header": "sp|Q32KP1-1|TSN31_BOVIN Isoform 1 of Tetraspanin-31 OS=Bos taurus OX=9913 GN=TSPAN31 PE=2 SV=1 CANONICAL=Q32KP1-1" }, "locus": { "chromosome": "5", "start_pos": 55719220, "end_pos": 55717055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009419.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009419.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009419.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009419.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 100, "start_aa": "Asn", "end_pos": 100, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn100", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 109, "start_aa": "Asn", "end_pos": 109, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn109", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 117, "start_aa": "Asn", "end_pos": 117, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn117", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 134, "start_aa": "Asn", "end_pos": 134, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn134", "evidence": [ { "id": "Q32KP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510619", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510619", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5U1V9-1", "protein_name": "Tetraspanin-31", "gene_name": "Tspan31", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACGGFACSKNALCALNVVYMLVGLLLIGVAAWGKGLGVVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFGISCSCLAINRNTQADVINASWWVLSNSTRHELERSFDCCGLFNLTTVHLHDDASCSALCKTRSSPCQMCGETFLKHSDKALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 210 }, "evidence": [ { "id": "Q32KP1", "url": "https://omabrowser.org/oma/group/Q32KP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQ88-1", "protein_name": "Tetraspanin-31", "gene_name": "Tspan31", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVCGGFACSRNALCALNVVYMLVGFLLIGVAAWGKGLGVVSSIHIIGGVIAVGVFLLLIAVAGLVGAANHHQVLLFFYMIILGLVFIFQFGISCSCLAINRNTQADVINASWSVLSNSTRHELERSFDCCGLFNLTTLRLQDDTSCSAVCKTKSSTCQMCGERFLKHSDKALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL", "length": 210 }, "evidence": [ { "id": "Q32KP1", "url": "https://omabrowser.org/oma/group/Q32KP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32KP1", "url": "https://www.uniprot.org/uniprotkb/Q32KP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 210, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KP1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 100, 109, 117, 134 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 109, "end_pos": 111 }, { "start_pos": 117, "end_pos": 119 }, { "start_pos": 134, "end_pos": 136 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBH6-1", "uniprot_ac": "Q2TBH6", "uniprot_id": "ELP4_BOVIN", "mass": { "chemical_mass": 46430.0, "monoisotopic_mass": 46430.0 }, "refseq": { "ac": "NP_001033773", "name": "elongator complex protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033773" }, "gene_names": [ { "name": "ELP4", "type": "recommended", "evidence": [ { "id": "Q2TBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ] }, { "name": "ELP4", "type": "synonym", "evidence": [ { "id": "NP_001033773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033773" } ] } ], "protein_names": [ { "name": "Elongator complex protein 4", "type": "recommended", "evidence": [ { "id": "Q2TBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#names_and_taxonomy" } ] }, { "name": "elongation protein 4 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033773" } ] }, { "name": "elongator complex protein 4", "type": "synonym", "evidence": [ { "id": "NP_001033773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033773" } ] } ], "function": [ { "annotation": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6#function" }, { "database": "UniProtKB", "id": "Q96EB1", "url": "https://www.uniprot.org/uniprotkb/Q96EB1#function" }, { "database": "UniProtKB", "id": "A0A3Q1M5R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5R0#function" }, { "database": "UniProtKB", "id": "ARBA00045238", "url": "https://www.uniprot.org/uniprotkb/ARBA00045238#function" }, { "database": "UniProtKB", "id": "A0A3Q1MFZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFZ1#function" }, { "database": "UniProtKB", "id": "A0AAA9U232", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U232#function" }, { "database": "UniProtKB", "id": "A0A3Q1LLU9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU9#function" }, { "database": "UniProtKB", "id": "A0AAA9SK18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK18#function" }, { "database": "UniProtKB", "id": "A0AAA9SYZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ5#function" }, { "database": "UniProtKB", "id": "A0AAA9SSV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV7#function" }, { "database": "UniProtKB", "id": "A0AAA9T7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELP4", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6", "locus": { "chromosome": "15", "start_pos": 62554100, "end_pos": 62296511, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023831", "url": "https://www.ensembl.org/id/ENSBTAG00000023831" } ] } } ], "crossref": [ { "id": "Q2TBH6", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023831", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023831", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19494", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19494", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614139", "url": "https://www.ncbi.nlm.nih.gov/gene/614139", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614139", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614139", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NTTMWDD", "url": "https://omabrowser.org/oma/group/NTTMWDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBH6", "url": "https://www.orthodb.org/?gene=Q2TBH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12896", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12896", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12896:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12896:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033773", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLU9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLU9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5R0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5R0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U232", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U232", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U232-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U232-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIERLHLPPDLSDTVSRSSKQDLAESTKLLGPGCGMTAGGKKHLDF", "length": 423, "header": "sp|Q2TBH6-1|ELP4_BOVIN Isoform 1 of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=2 SV=1 CANONICAL=Q2TBH6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLU9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0A3Q1LLU9-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIEVSQEAGKVVWYSRLFNSS", "length": 398, "header": "tr|A0A3Q1LLU9-1|A0A3Q1LLU9_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=2 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62519738, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066588.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066588.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060799.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060799.2" } ] } }, { "isoform_ac": "A0A3Q1M5R0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0A3Q1M5R0-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIEPAEGPCSGRQVPSLLPQPGPTPTASHPLPWIPH", "length": 413, "header": "tr|A0A3Q1M5R0-1|A0A3Q1M5R0_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=2 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62510711, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084764.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084764.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063608.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063608.2" } ] } }, { "isoform_ac": "A0A3Q1MFZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0A3Q1MFZ1-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIESLLRAPTLFLPQVVSFARGCQRPS", "length": 404, "header": "tr|A0A3Q1MFZ1-1|A0A3Q1MFZ1_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=2 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62453697, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068884.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068884.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067896.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067896.2" } ] } }, { "isoform_ac": "A0AAA9SK18-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0AAA9SK18-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIESCMDVRVGL", "length": 389, "header": "tr|A0AAA9SK18-1|A0AAA9SK18_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62429622, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108690.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108690.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084269.1" } ] } }, { "isoform_ac": "A0AAA9SSV7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0AAA9SSV7-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIECKQVHGL", "length": 387, "header": "tr|A0AAA9SSV7-1|A0AAA9SSV7_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62466530, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087773.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087773.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089490.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089490.1" } ] } }, { "isoform_ac": "A0AAA9SYZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0AAA9SYZ5-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEQAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIEWVQDNYLRQERNIYPPGFSYLLKQKDSAWGEGSLQHSTFLMSFLAKATAFASRLVRHCEPLKQTGSGRIHQAAGPRLWHDGRRQEAPGLLVTPP", "length": 475, "header": "tr|A0AAA9SYZ5-1|A0AAA9SYZ5_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62553694, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114948.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114948.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089308.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089308.1" } ] } }, { "isoform_ac": "A0AAA9T7Z5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0AAA9T7Z5-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIEPKDKG", "length": 385, "header": "tr|A0AAA9T7Z5-1|A0AAA9T7Z5_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62543652, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128690.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128690.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094059.1" } ] } }, { "isoform_ac": "A0AAA9U232-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#A0AAA9U232-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIESTSSRAHGRSSCGTMLRYPTAGRVESSQTRDQTLIPCISRQIRYRWTTREIPEYIFNYISGQV", "length": 443, "header": "tr|A0AAA9U232-1|A0AAA9U232_BOVIN Computationally mapped isoform of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=3 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62441507, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114516.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114516.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103423.1" } ] } }, { "isoform_ac": "Q2TBH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6/entry#Q2TBH6-1", "sequence": { "sequence": "MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIERLHLPPDLSDTVSRSSKQDLAESTKLLGPGCGMTAGGKKHLDF", "length": 423, "header": "sp|Q2TBH6-1|ELP4_BOVIN Isoform 1 of Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=2 SV=1 CANONICAL=Q2TBH6-1" }, "locus": { "chromosome": "15", "start_pos": 62553680, "end_pos": 62296546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005990.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005990.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005990.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005990.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614139", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614139", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JU71-1", "protein_name": "Elongator complex protein 4", "gene_name": "Elp4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAATCGAGVLSSGCVASTAGRSSTTSFQRRSKASGADGGGPRLLSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYSIYSPLLFKYFLAEGIVNGHTLLVASAKEKPADILQELPAPLLDDNGKKELEDVHNSKTPESDVNMKIAWRYQLQPKMQVGPVSSSRFGHYYDVSKRIPQELLGSSKWHGFFLPEHITSDLKGEPCSLSGDYMKLLQFIQNIIYTEGFDGSNPQKKQKNILRIGIQNFGSPFWGDDICCTENSDNSHRLTKFFYVLRGLLRTSLSACIITMPTHLIQNKAITARVRNLSDTVVGLESFIGSEKETNSLYKDYHGLIHIRKIPRLNNLTCDESDVKDLAFKLKRKLFTIEGWVWNSNICLSLPPECLEKATAFASRLVRHSESLKQTGSGRIRQAAGPRLWHDGRRQEAPGLLGNPP", "length": 446 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1M086-1", "protein_name": "Elongator complex protein 4", "gene_name": "Elp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAATCGAGTLSSECVASEAGQSRTSSFQRRGKASGAPGGGPRLLSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKENPANILQELPAPLLDDNGKKELEDVHSAKPPEADANMKIAWRYQLQPRMEQVGPVLSSRFGHYYDVSRRIPQELLESSNWHGFFLPEHTPPGLKGEPCFLSCGYMKLLQFFQNIIYTEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENSDNHHRLTKFLYILRGLLRSSLSACIITMPAQLVQNKAITTRVRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLTCDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVGRSSRQDLAPSTTLLGTGCSGMTGGKKRLDF", "length": 423 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SGP7-1", "protein_name": "Elongator complex protein 4", "gene_name": "ELP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVATCGTCTGSPGSTVAAASKNNVTSFQRRGPRASGSDSGYSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPADILQELPAPLLDDNCKKEFDEDVHNHKTPESNIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDLSKRIPQELIEASKWHRFFLPEKISSTFNVEPCSLTHGYKRLLQFIQNIIYEEGFDGSNPQKKQKNILRIGIQSLGSPLWGDDICCTENCDNSHSLTKFLYILRGLLRASLSACIITMPTHLIQNKAIIARVTNLSDIVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDVSDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSGKQDLAESAKLLGPGCGMMAGGEKHLDF", "length": 424 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54XS0-1", "protein_name": "Elongator complex protein 4", "gene_name": "elp4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTPRVPTTFTRKVAGGVKTTTTGSSLPTNNTSTTTTTTTTAAKKLPNGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLIGIDPFEILNKLPARITKEEEIEADKNDTTNNINTNINTNNNNKQPTDELKIAWRYQQYVSNELSKQQQQQSASTIMNQTFCHSYDFTRKMNVQSMNPELIHTLSHDAQSQAEGTSPYRNLFLEIQNLVYKYNKEAAMNPDQTRVLRLCIQSFSSPLWSNDEEGVIEFLHALKGLLRSSVATCVISVPTYIYSGAFVKKIAHLCDTVVSINSFSGLGGETPEQFAEYLGLFNIRKIARLNTLSLSFHPDMLTFVFKMKRRKMCIETIHLPPESSRAGDSKPDNNDSNKNKSDQNNIVSKMKSGSGLLCGGGGGGSSNNNPLDF", "length": 439 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q566Y1-1", "protein_name": "Elongator complex protein 4", "gene_name": "elp4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPVRGMAVSSSIGNTTSFQKKTRSKLVFIPGTRPSVQNGQLLVSSGVSSLDYVIGGGLAVGTLLLVEEDRYDSYSRMLLKYFLAEGIVCGHELFLASARDHPDQIMQELPSPILDDVASMKMSEGQSQPNDPDNPDTMKIAWRYQNQPRVQTALASSSRFGHYYDASKTMDPELLQAAKYHSFYQLQETPVTTGLSSLPSPYLALLKSIQTLIQKEGFDGSTPQLRGRNVLRVGLHSLGSVLWGDDVCCKDNSAHCHALSTFLYALRGLLRTSLSVAMMTVPSHLIQSRAVMGRIIRLSDTAIALESFRGSEKETNPLYKDYHGLLYVRQIPRLNCLTSEVPDTKDLAFKLKRKQFTIERLHLPPDLSETVSRVSKADLAAGCASTATGNKHLHF", "length": 397 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96EB1-1", "protein_name": "Elongator complex protein 4", "gene_name": "ELP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF", "length": 424 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9C778-1", "protein_name": "Elongator complex protein 4", "gene_name": "ELP4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAPNVRSSSSFSRNISVVSSPQIPGLKSGPNGTAFISSGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTYMSQGLVNNQPLLYASPSKDPKGFLGTLPHPASSKEDKPTAPDPDQGESLRIAWQYRKYLENQKNAIDDYSNDFDMRKPLERQFLSGRPIDCVSLLDSSDLSIAQDHCATFLSKFPRNSSNIASIGRIAIQSFCSPLCEYSEKESDMLSFIRLLKSMLMVSNAVAIVTFPPSLLSPSSSKRLQHMADTLLSIKAIPDGDKELEKLLTGYKDINGFLNIHKVARINTQVPVILEAKTFSMSLKKRRFLALECLNQAPVDGSSGTSYGTSGSCSSKSGALDF", "length": 355 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9ER73-1", "protein_name": "Elongator complex protein 4", "gene_name": "Elp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAADTCGAGTLSSRSVASEAGQGGTSSFQRKGKASGGPGGGPRLLSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFMAEGIINGHTLLVASAKENPAKILQELPAPLLDDNSKKELEDVHSAKTPEPNVNMKIAWRYQLQPKMEVGPVSSSRFGHYYDLSKRIPWELLQSSKWHGFFLPEHISPDLKGESCFLSCGYMRLLEFIQKSVYAEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENCDNNHRLTKFLYILRGLLRSSLSACIITMPAHLVQNKSITTRVRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLTCDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVGRSSKQDLAASTARLGAGCSSMAEGKKHLDF", "length": 422 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VMQ7-1", "protein_name": "Elongator complex protein 4", "gene_name": "Elp4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTSFRKRTVQKPIRGTRTSPHTAQVITSSGNPYLDVVIGGGLPMGSICLIEEDRFMTHAKVLAKYFLAEGVISKQEIFLGSLDDIPAEMLRRLPRPLTDQESMEQSEVQALGDAGAENGLRIAWRYNDLPLVNSEHATAKIGHHFNLMEQMDSMMLYNVKTTLWDDSPKHLDIVIDEEFSKSSSPTTPSLEQQPVEDAPPIPGTETAPQEKMPAQEEENSANNNNNNNNNSSSVTSSTKTGSQDSPLQVFHNPRYKGLLNDIQQLLRNESFVAGTKNNLCRVCLTSLGSPLWYDEHFGEDLIKFLTLLMASVRNCNSVCLITMPMHLIAKYDASLVPKIRQLVDYAIELESFAGSERETHPAFKEYSGLLHLHKMSAINTLAVHMPETPDLAFKLRRKKFIIEKFHLPPELQESSAKPDNCISGLLSNSNATASLDF", "length": 437 }, "evidence": [ { "id": "Q2TBH6", "url": "https://omabrowser.org/oma/group/Q2TBH6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" }, { "name": "elongator holoenzyme complex", "id": "GO:0033588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033588", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" }, { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH6", "url": "https://www.uniprot.org/uniprotkb/Q2TBH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 423, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBH6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 25, "end_pos": 27 }, { "start_pos": 318, "end_pos": 320 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9N4-1", "uniprot_ac": "Q2T9N4", "uniprot_id": "PMF1_BOVIN", "mass": { "chemical_mass": 23416.0, "monoisotopic_mass": 23416.0 }, "refseq": { "ac": "NP_001033301", "name": "polyamine-modulated factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033301" }, "gene_names": [ { "name": "PMF1", "type": "recommended", "evidence": [ { "id": "Q2T9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ] }, { "name": "PMF1", "type": "synonym", "evidence": [ { "id": "NP_001033301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033301" } ] } ], "protein_names": [ { "name": "Polyamine-modulated factor 1", "type": "recommended", "evidence": [ { "id": "Q2T9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4/entry#names_and_taxonomy" } ] }, { "name": "PMF-1", "type": "synonym", "evidence": [ { "id": "NP_001033301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033301" }, { "id": "Q2T9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4/entry#names_and_taxonomy" } ] }, { "name": "polyamine-modulated factor 1", "type": "synonym", "evidence": [ { "id": "NP_001033301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033301" } ] } ], "function": [ { "annotation": "Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PMF1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4", "locus": { "chromosome": "3", "start_pos": 14553830, "end_pos": 14575605, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009432", "url": "https://www.ensembl.org/id/ENSBTAG00000009432" } ] } } ], "crossref": [ { "id": "Q2T9N4", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9N4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009432", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009432", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616311", "url": "https://www.ncbi.nlm.nih.gov/gene/616311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616311", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616311", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHLAHLM", "url": "https://omabrowser.org/oma/group/IHLAHLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9N4", "url": "https://www.orthodb.org/?gene=Q2T9N4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15459", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15459", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15459:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15459:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03980", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03980", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033301", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SN66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9N4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEASSVNVGSGCAEKGPEELSQEPARPGTNISRVKLFDTMVDTFLQKLVAAGSFQRFTDCYKRFYQLQPEMTQRIYDKFVTQLQTSIQEEISEIKAEGNLEAVLIALDAIVEESKDRKEQAWRPSGIPEKDLRSAMAPYLLQQRDALQRRVQRQEAENRQLADAVLAGRRQLEELQLQAQARQQAWQALHREQKELLAVLKEPE", "length": 205, "header": "sp|Q2T9N4-1|PMF1_BOVIN Isoform 1 of Polyamine-modulated factor 1 OS=Bos taurus OX=9913 GN=PMF1 PE=2 SV=1 CANONICAL=Q2T9N4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN66-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4/entry#A0AAA9SN66-1", "sequence": { "sequence": "MAEASSVNVGSGCAEKGPEELSQEPARPGTNISRVKLFDTMVDTFLQKLVAAGSFQRFTDCYKRFYQLQPEMTQRIYDKFVTQLQTSIQEEISEIKAEGNLEAVLIALDAIVEESKDRKEQAWRPSGIPEKDLRSAMAPYLLQQRDALQRRVQRQEAENRQLADAVLAGRRQLEELQLQAQARQQAWQVSHDSQRGLLVGLEPNRRWVLSTIQMSSWCLLWPLDSSLPGANPPDPEQDRSPDP", "length": 243, "header": "tr|A0AAA9SN66-1|A0AAA9SN66_BOVIN Computationally mapped isoform of Polyamine modulated factor 1 OS=Bos taurus OX=9913 GN=PMF1 PE=4 SV=1 CANONICAL=Q2T9N4-1" }, "locus": { "chromosome": "3", "start_pos": 14575578, "end_pos": 14555487, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113290.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113290.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085332.1" } ] } }, { "isoform_ac": "Q2T9N4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4/entry#Q2T9N4-1", "sequence": { "sequence": "MAEASSVNVGSGCAEKGPEELSQEPARPGTNISRVKLFDTMVDTFLQKLVAAGSFQRFTDCYKRFYQLQPEMTQRIYDKFVTQLQTSIQEEISEIKAEGNLEAVLIALDAIVEESKDRKEQAWRPSGIPEKDLRSAMAPYLLQQRDALQRRVQRQEAENRQLADAVLAGRRQLEELQLQAQARQQAWQALHREQKELLAVLKEPE", "length": 205, "header": "sp|Q2T9N4-1|PMF1_BOVIN Isoform 1 of Polyamine-modulated factor 1 OS=Bos taurus OX=9913 GN=PMF1 PE=2 SV=1 CANONICAL=Q2T9N4-1" }, "locus": { "chromosome": "3", "start_pos": 14575578, "end_pos": 14554284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012411.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012411.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012411.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012411.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616311", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9QKW9-1", "protein_name": "Polyamine-modulated factor 1", "gene_name": "pmf1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEPEKSSESDSSKSNADKAGEVYAQASTRRNDSVKSSQPKPRLKLFSKVMEKSLQWLLDNASFDRFSHYFQPLSKQNPQLTEVMHKQFISQLQTLVQKEIATVIEEGDLQVKFEELDKLEELAKETAQAAWRPSGVPEQDICSDLVSSYKKQEEYMRIQLKKLLKENAALAQKVQAGRENITHTEQRIASGVQEWKASLEDLEEFVVTLSPSEHFESL", "length": 219 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZEH8-1", "protein_name": "Polyamine-modulated factor 1", "gene_name": "Pmf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGVSQDNEAAEKGPEGSSTEAVPGDTTISRVKLLDTIVDTFLQKLVAGKSYERFASCYKHLHQLNPEATRWIYDKFVAQLQTSIREEISEIKEEGNLEAVLNSLDKIIEEGKDRGETAWRPSGIPEKDLCSVMAPYFLKQQDTLCRQVQKQEAKNQELAEAVLAGRRQVEELQQQVQAVQQTWQALHREQRELLSVLRAPE", "length": 202 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RLQ4-1", "protein_name": "Polyamine modulated factor 1", "gene_name": "PMF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEVSSVNVASGSEEKGPEGLSQELPRPGTTISRVKLFDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQPEMTQRIYDKFITQLQTSIREEISEIKAEGNLEAVLNALDGIVEEGKDRKETAWRPSGIPEKDLRSTMVPYFLQQRDILQRRVQKQEAENRQLAEAVLAGRRQVEELQLQGQARQQAWQALHREQKELMAVLREPE", "length": 205 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HG92-1", "protein_name": "Polyamine-modulated factor 1 isoform X1", "gene_name": "Pmf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEVSHGNEAVGKGPEGSSPESVPVDTTVSRVKLLDTIVDTFLQKLVAARSYERFTNCYKHFHQLDPEVTKWVYDKFVAQLQTSIREEISEIKEEGNLEAVLNSLDKIVEEGKAHGEPAWRPSGIPEKDLCSVMAPYFLQQRNTLCHRVQKQEAKNQELADAVLAGRRQVEEMQQQVQALRQAWQALHKEQTELLSVLRAPE", "length": 202 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6P1K2-1", "protein_name": "Polyamine-modulated factor 1", "gene_name": "PMF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQVQAQQQAWQALHREQRELVAVLREPE", "length": 205 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CPV5-1", "protein_name": "Polyamine-modulated factor 1", "gene_name": "Pmf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEVSRDSEAAERGPEGSSPEAVPGDATIPRVKLLDAIVDTFLQKLVADRSYERFTTCYKHFHQLNPEVTQRIYDKFVAQLQTSIREEISEIKEEGNLEAVLNSLDKIIEEGRERGEPAWRPSGIPEKDLCSVMAPYFLKQQDTLCHQVRKQEAKNQELADAVLAGRRQVEELQQQVRALQQTWQALHREQRELLSVLRAPE", "length": 202 }, "evidence": [ { "id": "Q2T9N4", "url": "https://omabrowser.org/oma/group/Q2T9N4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "pmid": "" }, { "name": "MIS12/MIND type complex", "id": "GO:0000444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000444", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N4", "url": "https://www.uniprot.org/uniprotkb/Q2T9N4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9N4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9N4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9N4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DU8-1", "uniprot_ac": "Q58DU8", "uniprot_id": "NR2CA_BOVIN", "mass": { "chemical_mass": 15929.0, "monoisotopic_mass": 15929.0 }, "refseq": { "ac": "NP_001029499", "name": "nuclear receptor 2C2-associated protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" }, "gene_names": [ { "name": "NR2C2AP", "type": "recommended", "evidence": [ { "id": "Q58DU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU8" } ] }, { "name": "NR2C2AP", "type": "synonym", "evidence": [ { "id": "NP_001029499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" } ] }, { "name": "TRA16", "type": "synonym", "evidence": [ { "id": "NP_001029499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" }, { "id": "Q58DU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU8" } ] } ], "protein_names": [ { "name": "Nuclear receptor 2C2-associated protein", "type": "recommended", "evidence": [ { "id": "Q58DU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU8/entry#names_and_taxonomy" } ] }, { "name": "TR4 orphan receptor associated protein TRA16", "type": "synonym", "evidence": [ { "id": "NP_001029499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" } ] }, { "name": "TR4 orphan receptor-associated 16 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001029499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" }, { "id": "Q58DU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU8/entry#names_and_taxonomy" } ] }, { "name": "nuclear receptor 2C2-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001029499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499" } ] } ], "function": [ { "annotation": "May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.", "evidence": [ { "database": "UniProtKB", "id": "Q58DU8", "url": "https://www.uniprot.org/uniprotkb/Q58DU8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DU8", "url": "https://www.uniprot.org/uniprotkb/Q58DU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR2C2AP", "url": "https://www.uniprot.org/uniprotkb/Q58DU8", "locus": { "chromosome": "7", "start_pos": 4060107, "end_pos": 4057893, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001763", "url": "https://www.ensembl.org/id/ENSBTAG00000001763" } ] } } ], "crossref": [ { "id": "Q58DU8", "url": "https://alphafold.ebi.ac.uk/entry/Q58DU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001763", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001763", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508684", "url": "https://www.ncbi.nlm.nih.gov/gene/508684", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508684", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508684", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FFGRITV", "url": "https://omabrowser.org/oma/group/FFGRITV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DU8", "url": "https://www.orthodb.org/?gene=Q58DU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "NP_001029499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029499", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DU8", "url": "https://www.uniprot.org/uniprotkb/Q58DU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DU8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQCICVSQLQIQFQGGFSSRQGRLEGSLGSEALSKIVDFYPEDNNSLQTFPVPPAEVDRLKVTFEDTTDFFGRVVIYHLRVLGKKKE", "length": 140, "header": "sp|Q58DU8-1|NR2CA_BOVIN Isoform 1 of Nuclear receptor 2C2-associated protein OS=Bos taurus OX=9913 GN=NR2C2AP PE=2 SV=1 CANONICAL=Q58DU8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNA7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU8/entry#A0AAA9SNA7-1", "sequence": { "sequence": "MAHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQVLWGVRLLARLW", "length": 55, "header": "tr|A0AAA9SNA7-1|A0AAA9SNA7_BOVIN Computationally mapped isoform of Nuclear receptor 2C2 associated protein OS=Bos taurus OX=9913 GN=NR2C2AP PE=4 SV=1 CANONICAL=Q58DU8-1" }, "locus": { "chromosome": "7", "start_pos": 4059160, "end_pos": 4058259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107204.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107204.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086824.1" } ] } }, { "isoform_ac": "Q58DU8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU8/entry#Q58DU8-1", "sequence": { "sequence": "MAHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQCICVSQLQIQFQGGFSSRQGRLEGSLGSEALSKIVDFYPEDNNSLQTFPVPPAEVDRLKVTFEDTTDFFGRVVIYHLRVLGKKKE", "length": 140, "header": "sp|Q58DU8-1|NR2CA_BOVIN Isoform 1 of Nuclear receptor 2C2-associated protein OS=Bos taurus OX=9913 GN=NR2C2AP PE=2 SV=1 CANONICAL=Q58DU8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DU8", "url": "https://www.uniprot.org/uniprotkb/Q58DU8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508684", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508684", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AI65-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "Nr2c2ap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTQSLVCPETVSRVSSVLNRNSRQFGKKHLFDQDEETCWNSDQGPCQWVSLEFPQRVQITQLQVQFQGGFSSRHSRLEGSRDGEALSKIVDFYPEDTNALQTFSIPTMEVDRLKLTFEDTTDFFGRVVIYHLRVLGEKAG", "length": 140 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IPI2-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "Nr2c2ap", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQSLVCPETVSRVSSVLNRNSRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQRVHVTQLQVQFQGGFSSRHSYLEGSQSGDTLSKIVDFYPEDTNALQTFSIPTVEVDRLKLTFEDTTDFFGRVVIYHLRVLGEKAV", "length": 140 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LF75-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "NR2C2AP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTHSLVCPETVSKVSSVLNRNYRQFGKKHLFDQDEETCWNSDQGPSQWIILEFPQRICVSQLQIQFQGGFSSRQGRLEGSQGSEALAKIVDFYPEDNNSLQTFPVPAAEVDRLKVTFEDTTDFFGRVVIYHLRVLGEKKV", "length": 140 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TV70-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "Nr2c2ap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQSLVCPDTVSRVSSVLNRNSRQFGKKHLFDQDEETCWNSDQGPSQWVSLEFPQCVQITQLQVQFQGGFSSRHSCLEGSRGGEALSKIVDFYPEDTNALQTFSIPTMEVDRLKLTFEDTTDFFGRVVIYHLRVLGEKAG", "length": 140 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54VC6-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQSLLVGDYKCRVSSVLNKQTKEYGKENLFDKSEETCWNSHQGTPQFIVIQFPQENGVTLSSVNIMFQGGFVGKDCEILTMSTNSDSKEFIHSCYFYPKDINTTQQFPIDSIKNTNIKQIKILFPQSTDFFGRITIYQLDILGEPTL", "length": 147 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86WQ0-1", "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "NR2C2AP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQLIRVSQLQIQFQGGFSSRRGCLEGSQGTQALHKIVDFYPEDNNSLQTFPIPAAEVDRLKVTFEDATDFFGRVVIYHLRVLGEKV", "length": 139 }, "evidence": [ { "id": "Q58DU8", "url": "https://omabrowser.org/oma/group/Q58DU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58DU8", "url": "https://www.uniprot.org/uniprotkb/Q58DU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DU8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DU8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DU8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32L94-1", "uniprot_ac": "Q32L94", "uniprot_id": "D42E1_BOVIN", "mass": { "chemical_mass": 43740.0, "monoisotopic_mass": 43740.0 }, "refseq": { "ac": "NP_001073761", "name": "short-chain dehydrogenase/reductase family 42E member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073761" }, "gene_names": [ { "name": "SDR42E1", "type": "recommended", "evidence": [ { "id": "Q32L94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ] }, { "name": "HSPC105", "type": "synonym", "evidence": [ { "id": "NP_001073761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073761" } ] }, { "name": "SDR42E1", "type": "synonym", "evidence": [ { "id": "NP_001073761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073761" } ] } ], "protein_names": [ { "name": "Short-chain dehydrogenase/reductase family 42E member 1", "type": "recommended", "evidence": [ { "id": "Q32L94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.-", "type": "synonym", "evidence": [ { "id": "Q32L94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#names_and_taxonomy" } ] }, { "name": "short-chain dehydrogenase/reductase family 42E member 1", "type": "synonym", "evidence": [ { "id": "NP_001073761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073761" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDR42E1", "url": "https://www.uniprot.org/uniprotkb/Q32L94", "locus": { "chromosome": "18", "start_pos": 8543771, "end_pos": 8574856, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018394", "url": "https://www.ensembl.org/id/ENSBTAG00000018394" } ] } } ], "crossref": [ { "id": "Q32L94", "url": "https://alphafold.ebi.ac.uk/entry/Q32L94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018394", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018394", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09812", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09812", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532489", "url": "https://www.ncbi.nlm.nih.gov/gene/532489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGAYKRS", "url": "https://omabrowser.org/oma/group/IGAYKRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L94", "url": "https://www.orthodb.org/?gene=Q32L94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43245:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43245:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073761", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SP01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5R7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5R7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5R7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L94-1", "url": "https://www.uniprot.org/uniprotkb/Q32L94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSHKSPKETVLITGGGGYFGFRLGCALNLLGVHVILFDISHPAQTIPEGIRFILGDIRCLSDIENAFQGVDVACVFHIASYGMSGREQLNRSLIEEINVGGTDNILQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLSANGTALERGGGVLSTCALRPAGIYGPGEQRHLPRIVSYIEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKANKGHIAAGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSTRLPLTLIYCFAFLTEMTHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKARKELGYEAQPFDLQEAVEWFKAHGHGRRPGSCDSKCLVWDGLVILLVVTVVLVWLLPSVILSM", "length": 393, "header": "sp|Q32L94-1|D42E1_BOVIN Isoform 1 of Short-chain dehydrogenase/reductase family 42E member 1 OS=Bos taurus OX=9913 GN=SDR42E1 PE=2 SV=2 CANONICAL=Q32L94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP01-1", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#A0AAA9SP01-1", "sequence": { "sequence": "MREVNATPSHRSSYLSLPHMDSHKSPKETVLITGGGGYFGFRLGCALNLLGVHVILFDISHPAQTIPEGIRFILGDIRCLSDIENAFQGVDVACVFHIASYGMSGREQLNRSLIEEINVGGTDNILQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLSANGTALERGGGVLSTCALRPAGIYGPGEQRHLPRIVSYIEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKANKGHIAAGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSTRLPLTLIYCFAFLTEMTHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKARKELGYEAQPFDLQEAVEWFKAHGHGRRPGSCDSKCLVWDGLVILLVVTVVLVWLLPSVILSM", "length": 412, "header": "tr|A0AAA9SP01-1|A0AAA9SP01_BOVIN Computationally mapped isoform of Short chain dehydrogenase/reductase family 42E, member 1 OS=Bos taurus OX=9913 GN=SDR42E1 PE=3 SV=1 CANONICAL=Q32L94-1" }, "locus": { "chromosome": "18", "start_pos": 8557208, "end_pos": 8544775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121212.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121212.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088051.1" } ] } }, { "isoform_ac": "A0AAA9SRC6-1", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#A0AAA9SRC6-1", "sequence": { "sequence": "MQVFYRLGCALNLLGVHVILFDISHPAQTIPEGIRFILGDIRCLSDIENAFQGVDVACVFHIASYGMSGREQLNRSLIEEINVGGTDNILQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLSANGTALERGGGVLSTCALRPAGIYGPGEQRHLPRIVSYIEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKANKGHIAAGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSTRLPLTLIYCFAFLTEMTHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKARKELGYEAQPFDLQEAVEWFKAHGHGRRPGSCDSKCLVWDGLVILLVVTVVLVWLLPSVILSM", "length": 376, "header": "tr|A0AAA9SRC6-1|A0AAA9SRC6_BOVIN Computationally mapped isoform of Short chain dehydrogenase/reductase family 42E, member 1 OS=Bos taurus OX=9913 GN=SDR42E1 PE=3 SV=1 CANONICAL=Q32L94-1" }, "locus": { "chromosome": "18", "start_pos": 8546883, "end_pos": 8544775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104227.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104227.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086625.1" } ] } }, { "isoform_ac": "A0AAA9T5R7-1", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#A0AAA9T5R7-1", "sequence": { "sequence": "MEHLHYIRQFLYMFPFGLQNPASLFLALMFNAATARMNLSKWSSYLSLPHMDSHKSPKETVLITGGGGYFGFRLGCALNLLGVHVILFDISHPAQTIPEGIRFILGDIRCLSDIENAFQGVDVACVFHIASYGMSGREQLNRSLIEEINVGGTDNILQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLSANGTALERGGGVLSTCALRPAGIYGPGEQRHLPRIVSYIEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKANKGHIAAGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSTRLPLTLIYCFAFLTEMTHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKARKELGYEAQPFDLQEAVEWFKAHGHGRRPGSCDSKCLVWDGLVILLVVTVVLVWLLPSVILSM", "length": 443, "header": "tr|A0AAA9T5R7-1|A0AAA9T5R7_BOVIN Computationally mapped isoform of Short chain dehydrogenase/reductase family 42E, member 1 OS=Bos taurus OX=9913 GN=SDR42E1 PE=3 SV=1 CANONICAL=Q32L94-1" }, "locus": { "chromosome": "18", "start_pos": 8548049, "end_pos": 8544775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094114.1" } ] } }, { "isoform_ac": "Q32L94-1", "url": "https://www.uniprot.org/uniprotkb/Q32L94/entry#Q32L94-1", "sequence": { "sequence": "MDSHKSPKETVLITGGGGYFGFRLGCALNLLGVHVILFDISHPAQTIPEGIRFILGDIRCLSDIENAFQGVDVACVFHIASYGMSGREQLNRSLIEEINVGGTDNILQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLSANGTALERGGGVLSTCALRPAGIYGPGEQRHLPRIVSYIEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKANKGHIAAGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSTRLPLTLIYCFAFLTEMTHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKARKELGYEAQPFDLQEAVEWFKAHGHGRRPGSCDSKCLVWDGLVILLVVTVVLVWLLPSVILSM", "length": 393, "header": "sp|Q32L94-1|D42E1_BOVIN Isoform 1 of Short-chain dehydrogenase/reductase family 42E member 1 OS=Bos taurus OX=9913 GN=SDR42E1 PE=2 SV=2 CANONICAL=Q32L94-1" }, "locus": { "chromosome": "18", "start_pos": 8546976, "end_pos": 8544775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048714.3", "url": "https://www.ensembl.org/id/ENSBTAT00000048714.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045705.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045705.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532489", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532489", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JT58-1", "protein_name": "Short chain dehydrogenase/reductase family 42E, member 1", "gene_name": "Sdr42e1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSPRFPEETVLITGGGGYFGFRLGCALNQKGVRVILFDIIEPAQNLPEGITFVRGDIRCLSDVEAAFQDADIACVFHIASYGMSGREQLNKTRIEEVNVGGTENILQACLGRGVPSLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLEANGLAFKQGDGVLRTCAIRPAGIYGAGEQRHLPRVVSYIERGLFRFVYGDPQSLVEFVHVDNLAKAHILASEALKADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPTTRLPLTLIYYFAFLIEMTHLIVGRLYNFQPFLTCTEVYKTGVTHYFSLEKAKSELGYAPQPFDLQEVVEWFKAHGHGRRPRGQDSEFILWDGILVLLLAFSVLTWIPPSTILSL", "length": 393 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287A6U6-1", "protein_name": "Short chain dehydrogenase/reductase family 42E, member 1", "gene_name": "SDR42E1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSPRSPKETVLITGGGGYFGFRLGCALNQKGLRVILFDVSSPAHTIPEGVKFIRGDIRLLADVERAFEDADVTCVFHIASYGMSGREQLNRSRIEDVNVGGTDNVLQACRSRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSVAEKKVLEANGTALARRAGVLRTCALRPAGIYGPGEQRHLPRIVSYLEKGLFRFVYGDPKSLVEFVHVDNLVQAHILASEALKADKGHVASGQPYFISDGRPVNNFEFFRPLVEGLGYKFPSVRLPLPLIYFFAFLTEMAYFLLGRLYNFQPFLTRTEVYKTAVTHYFSLEKAKKELGYEAQPFDLQEVVEWFKAHGHGRSPGRQDSEFSLVWYGLLVSLLIIAVLTWLPPSVILSL", "length": 394 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HUK5-1", "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "Sdr42e1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDSPRFSEETVLITGGGGYFGFRLGCALNQKGVRVILFDISQPAQNLPEGIRFIRGDICCLSDVEMAFRDTDIACVFHVASYGMSGREQLNKTLIEEVNVGGTNNILQTCLERGVPRLVYTSTVNVVFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLEADGSAFKQGNGVLRTCALRPAGIYGVGEQRHLPRIVSYIERGLFRFIFGDPNSLVEFVHVDNLVKAHILASEALKADKGHVASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSIRLPFTLIYCFAFLVEMTHFILSRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYEPQPFDLQEVVEWFKVQGHGRRSGGQDSEFILWDGILVLLLALSLLTWFPPSTVLNL", "length": 393 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y0K1-1", "protein_name": "Short chain dehydrogenase/reductase family 42E, member 1", "gene_name": "SDR42E1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAGSSAKETVLITGGGGYFGFRLGCTIYKKGVDVILFDVTKPLQPVPEGIKFMQGNVCCLAEVEEALKDVICVFHIASYGMSGREQLNRKLIEDVNVKGTENVIQACKSTGVSSLVYTSTYNVIFGGQIIENGDESLPYLPLHLHPDHYSRTKSLAEMKVLKANGTELGNGKGVLRTCALRPAGIYGPGEQRHLPRIVSYIERGLFKFVYGDPLSLVEFVHVDNLVQAHILAFEALKANKKHIAAGQAYFISDGRPVNNFEFFRPLVEGLGYKFPTCRLPLSLVYFFAFLTEVVHLLVGHVYNFQPLLTRTEVYKTGVTHYFSMEKARKELGYEPQKYSLNEVVEWFRSQGCGPKPRKYTITHLLRDGGLLLLFIAVLVSWFPPAVIFSP", "length": 391 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A8DZE7-1", "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "sdr42e1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEVNRKDNSFLITGGGGYFGFRLACALLKTSSKVVLFDVSPPIQDLPEGLIFMRADIRDYAQVEKAVRGSHCVFHIASYGMSGREQLNRKLIEEVNVKGTENILRACVAHSVPRLIYTSTFNVVFGGQEIKNGDESLPYLPLHLHPDHYSRTKSIAEMQVLKANNLALSNSTGVLRTCALRPAGIYGPGEQRHLPRIVSYIENGIFRFVYGDPDSLVEFVHVDNLVSAHLLAADALTEKQQCRAAGQAYFISDGRPVNNFEFFRPLVEGLGYSFPTLRLPISMIYFFAFLTEMVHFVVGRIYNFQPLLTRTEVYKTGVTHYFSMRKAREELGYEPKLYDLEDVVQWFQARGHGKKRSRSSIRKLILDVFVVVAFVAVLLSCLPVVGQ", "length": 387 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8WUS8-1", "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "SDR42E1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPKRSQKESVLITGGSGYFGFRLGCALNQNGVHVILFDISSPAQTIPEGIKFIQGDIRHLSDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEQKVLEANATPLDRGDGVLRTCALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHILASEALRADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLVYCFAFLTEMVHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYKAQPFDLQEAVEWFKAHGHGRSSGSRDSECFVWDGLLVFLLIIAVLMWLPSSVILSL", "length": 393 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D665-1", "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "Sdr42e1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSPRFPEETVLITGGGGYFGFRLGCALNQKGARVILFDITQPAQNLPEGIKFVCGDIRCLADVETAFQDAEKVACVFHVASYGMSGREQLNKTQIEEVNVGGTENILRACLERGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEKKVLEANGLAFKQGDGILRTCAIRPAGIYGAGEQRHLPRIVSYIERGLFRFVYGDPQSLVEFVHVDNLAKAHILASEALKADKGHVASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLIYCLAFLVEMTHFIVGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGFEPQPFDLQEVVEWFKAHGHGRGAAGQDSEFMLWDGILILLLALSVLTWILPSTTLSI", "length": 394 }, "evidence": [ { "id": "Q32L94", "url": "https://omabrowser.org/oma/group/Q32L94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "Q32L94", "url": "https://www.uniprot.org/uniprotkb/Q32L94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L94" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2LDA0-1", "uniprot_ac": "Q2LDA0", "uniprot_id": "Q2LDA0_BOVIN", "mass": { "chemical_mass": 98002.0, "monoisotopic_mass": 98002.0 }, "refseq": { "ac": "NP_001035591", "name": "toll-like receptor 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" }, "gene_names": [ { "name": "TLR5", "type": "recommended", "evidence": [ { "id": "Q2LDA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ] }, { "name": "TLR-5", "type": "synonym", "evidence": [ { "id": "NP_001035591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" } ] }, { "name": "TLR5", "type": "synonym", "evidence": [ { "id": "NP_001035591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" } ] } ], "protein_names": [ { "name": "Toll-like receptor 5", "type": "recommended", "evidence": [ { "id": "Q2LDA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0/entry#names_and_taxonomy" } ] }, { "name": "toll-like receptor 5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001035591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" } ] } ], "function": [ { "annotation": "Both HEK293 (human origin) and embryonic bovine lung cells transfected with bTLR5 responded to addition of H7 flagellin. Responses were significantly reduced when mutations were introduced into the TLR5-binding regions of H7 flagellin. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" }, { "database": "PubMed", "id": "25827709", "url": "https://glygen.org/publication/PubMed/25827709" } ] }, { "annotation": "Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0#function" }, { "database": "UniProtKB", "id": "ARBA00057507", "url": "https://www.uniprot.org/uniprotkb/ARBA00057507#function" }, { "database": "UniProtKB", "id": "A0AAA9SQ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ36#function" } ] }, { "annotation": "Prediction and comparison of TLR protein domain architectures for multiple species revealed seven conserved regions of LRR patterning associated with the three genes investigated.", "evidence": [ { "database": "RefSeq", "id": "NP_001035591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" }, { "database": "PubMed", "id": "17719743", "url": "https://glygen.org/publication/PubMed/17719743" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TLR5", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0", "locus": { "chromosome": "16", "start_pos": 26599830, "end_pos": 26625340, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000477", "url": "https://www.ensembl.org/id/ENSBTAG00000000477" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000477", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000477", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "444870", "url": "https://www.ncbi.nlm.nih.gov/gene/444870", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:444870", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444870", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F6PXR5", "url": "https://www.orthodb.org/?gene=F6PXR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2LDA0", "url": "https://www.orthodb.org/?gene=Q2LDA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24365", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24365", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24365:SF525", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24365:SF525", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXR5", "url": "https://www.uniprot.org/uniprotkb/F6PXR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXR5-1", "url": "https://www.uniprot.org/uniprotkb/F6PXR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2LDA0-1", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDCLDLLLGVVLLTSPALGMSSCFFDGWRAIYLSCNLTQVPQVPNTTKSLLLSFNYIRTVTTASFPFLEQLQLLELGTQFTPLTIYREAFRNLPNLRILDLGGSQINFLHPDAFQGLPHLTKLRLFSCGLSDAVLKDGYFRNLASLTHLDLSKNKIQSLYLHPSFRELNSLKSIDFSFNKIPIVCEQEFKPLQGKTLSFLSLADNQLYSRVSVDWNKCLNPFRNMVLETLDVSGNGWGVDIMRNFSNAINGSQIFSLVLTRHIMGSSFGFSNLKDPDYHTFAGLARSSMIQLDISHGYIFSLNFRIFETLQELKVLNLAYNKINSISRNAFYGLDNLQVLNISYNLLGELYNYDFDGLPKVAYIDLQKNHIGIIQDKTFKFLGKLNTLDLRDNALKTIYFLPSIPNIFLSGNKLMTLPNIPLTANFIQLSENRLENLNDLYFLLQVPHLQILILNQNRFSFCHQNHAPSENSSLEKLFLGENMLQLAWETGSCWDIFKGLSHLQLLYLNKNYLNFLPPGVFHHLTALRGLSLKDNRLTVLFPGDLPANLEILDISGNQLLSPDPDLFASLSAIDITHNNFICECELSAFIHWLNQTNITIAGSPADMYCMYPNSLAGVSIYSLSTESCEEEEVLESLKFSLFILVTVTLTLFLVITLAVTKFRGFCFICYKKAQSLLFKDPIKGRESDTYKYDAYLCFSSKDFEWVQNALLKHLDVQYHSQNRFNLCFEERDFMPGENHIANIQDAVWSSRKIVCLVSRHFLRDGWCLEAFSYAQSRCLADLNGALIMVVVGSLSQFHLMRHQSIRGFVQKRQYLRWPEDLQDVDWFLNKLSQCILKKEKERKKDSAIQLQNVTTIS", "length": 858, "header": "tr|Q2LDA0-1|Q2LDA0_BOVIN Isoform 1 of Toll-like receptor 5 OS=Bos taurus OX=9913 GN=TLR5 PE=3 SV=1 CANONICAL=Q2LDA0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ36-1", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0/entry#A0AAA9SQ36-1", "sequence": { "sequence": "MCVTASKVLWKPYHKSPPIQQRLFRACRIMGDCLDLLLGVVLLTSPALGMSSCFFDGWRAIYLSCNLTQVPQVPNTTKSLLLSFNYIRTVTTASFPFLEQLQLLELGTQFTPLTIYREAFRNLPNLRILDLGGSQINFLHPDAFQGLPHLTKLRLFSCGLSDAVLKDGYFRNLASLTHLDLSKNKIQSLYLHPSFRELNSLKSIDFSFNKIPIVCEQEFKPLQGKTLSFLSLADNQLYSRVSVDWNKCLNPFRNMVLETLDVSGNGWGVDIMRNFSNAINGSQIFSLVLTRHIMGSSFGFSNLKDPDYHTFAGLARSSMIQLDISHGYIFSLNFRIFETLQELKVLNLAYNKINSISRNAFYGLDNLQVLNISYNLLGELYNYDFDGLPKVAYIDLQKNHIGIIQDKTFKFLGKLNTLDLRDNALKTIYFLPSIPNIFLSGNKLMTLPNIPLTANFIQLSENRLENLNDLYFLLQVPHLQILILNQNRFSFCHQNHAPSENSSLEKLFLGENMLQLAWETGSCWDIFKGLSHLQLLYLNKNYLNFLPPGVFHHLTALRGLSLKDNRLTVLFPGDLPANLEILDISGNQLLSPDPDLFASLSAIDITHNNFICECELSAFIHWLNQTNITIAGSPADMYCMYPNSLAGVSIYSLSTESCEEEEVLESLKFSLFILVTVTLTLFLVITLAVTKFRGFCFICYKKAQSLLFKDPIKGRESDTYKYDAYLCFSSKDFEWVQNALLKHLDVQYHSQNRFNLCFEERDFMPGENHIANIQDAVWSSRKIVCLVSRHFLRDGWCLEAFSYAQSRCLADLNGALIMVVVGSLSQFHLMRHQSIRGFVQKRQYLRWPEDLQDVDWFLNKLSQCILKKEKERKKDSAIQLQNVTTIS", "length": 887, "header": "tr|A0AAA9SQ36-1|A0AAA9SQ36_BOVIN Computationally mapped isoform of Toll-like receptor 5 OS=Bos taurus OX=9913 GN=TLR5 PE=3 SV=1 CANONICAL=Q2LDA0-1" }, "locus": { "chromosome": "16", "start_pos": 26605077, "end_pos": 26601168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104408.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104408.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085042.1" } ] } }, { "isoform_ac": "A0AAA9THF1-1", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0/entry#A0AAA9THF1-1", "sequence": { "sequence": "MGDCLDLLLGVVLLTSPALGMSSCFFDGWRAIYLSCNLTQVPQVPNTTKSLLLSFNYIRTVTTASFPFLEQLQLLELGTQFTPLTIYREAFRNLPNLRILDLGGSQINFLHPDAFQGLPHLTKLRLFSCGLSDAVLKDGYFRNLASLTHLDLSKNKIQSLYLHPSFRELNSLKSIDFSFNKIPIVCEQEFKPLQGKTLSFLSLADNQLYSRVSVDWNKCLNPFRNMVLETLDVSGNGWGVDIMRNFSNAINGSQIFSLVLTRHIMGSSFGFSNLKDPDYHTFAGLARSSMIQLDISHGYIFSLNFRIFETLQELKVLNLAYNKINSISRNAFYGLDNLQVLNISYNLLGELYNYDFDGLPKVAYIDLQKNHIGIIQDKTFKFLGKLNTLDLRDNALKTIYFLPSIPNIFLSGNKLMTLPNIPLTANFIQLSENRLENLNDLYFLLQVPHLQILILNQNRFSFCHQNHAPSENSSLEKLFLGENMLQLAWETGSCWDIFKGLSHLQLLYLNKNYLNFLPPGVFHHLTALRGLSLKDNRLTVLFPGDLPANLEILDISGNQLLSPDPDLFASLSAIDITHNNFICECELSAFIHWLNQTNITIAGSPADMYCMYPNSLAGVSIYSLSTESCEEEEVLESLKFSLFILVTVTLTLFLVITLAVTKFRGFCFICYKKAQSLLFKDPIKGRESDTYKYDAYLCFSSKDFEWVQNALLKHLDVQYHSQNRFNLCFEERDFMPGENHIANIQDAVWSSRKIVCLVSRHFLRDGWCLEAFSYAQSRCLADLNGALIM", "length": 789, "header": "tr|A0AAA9THF1-1|A0AAA9THF1_BOVIN Computationally mapped isoform of Toll like receptor 5 OS=Bos taurus OX=9913 GN=TLR5 PE=3 SV=1 CANONICAL=Q2LDA0-1" }, "locus": { "chromosome": "16", "start_pos": 26603741, "end_pos": 26601375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096557.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096557.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096507.1" } ] } }, { "isoform_ac": "F6PXR5-1", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0/entry#F6PXR5-1", "sequence": { "sequence": "MGDCLDLLLGVVLLTSPALGMSSCFFDGWRAIYLSCNLTQVPQVPNTTKSLLLSFNYIRTVTTASFPFLEQLQLLELGTQFTPLTIYREAFRNLPNLRILDLGGSQINFLHPDAFQGLPHLTKLRLFSCGLSDAVLKDGYFRNLASLTHLDLSKNKIQSLYLHPSFRELNSLKSIDFSFNKIPIVCEQEFKPLQGKTLSFLSLADNQLYSRVSVDWNKCLNPFRNMVLETLDVSGNGWGVDIMRNFSNAINGSQIFSLVLTRHIMGSSFGFSNLKDPDYHTFAGLARSSMIQLDISHGYIFSLNFRIFETLQELKVLNLAYNKINSISRNAFYGLDNLQVLNISYNLLGELYNYDFDGLPKVAYIDLQKNHIGIIQDKTFKFLGKLNTLDLRDNALKTIYFLPSIPNIFLSGNKLMTLPNIPLTANFIQLSENRLENLNDLYFLLQVPHLQILILNQNRFSFCHQNHAPSENSSLEKLFLGENMLQLAWETGSCWDIFKGLSHLQLLYLNKNYLNFLPPGVFHHLTALRGLSLKDNRLTVLFPGDLPANLEILDISGNQLLSPDPDLFASLSAIDITHNNFICECELSAFIHWLNQTNITIAGSPADMYCMYPNSLAGVSIYSLSTESCEEEEVLESLKFSLFILVTVTLTLFLVITLAVTKFRGFCFICYKKAQSLLFKDPIKGRESDTYKYDAYLCFSSKDFEWVQNALLKHLDVQYHSQNRFNLCFEERDFMPGENHIANIQDAVWSSRKIVCLVSRHFLRDGWCLEAFSYAQSRCLADLNGAL", "length": 787, "header": "tr|F6PXR5-1|F6PXR5_BOVIN Computationally mapped isoform of Toll like receptor 5 OS=Bos taurus OX=9913 GN=TLR5 PE=3 SV=2 CANONICAL=Q2LDA0-1" }, "locus": { "chromosome": "16", "start_pos": 26603741, "end_pos": 26601381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000604.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000604.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000604.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000604.7" } ] } }, { "isoform_ac": "Q2LDA0-1", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0/entry#Q2LDA0-1", "sequence": { "sequence": "MGDCLDLLLGVVLLTSPALGMSSCFFDGWRAIYLSCNLTQVPQVPNTTKSLLLSFNYIRTVTTASFPFLEQLQLLELGTQFTPLTIYREAFRNLPNLRILDLGGSQINFLHPDAFQGLPHLTKLRLFSCGLSDAVLKDGYFRNLASLTHLDLSKNKIQSLYLHPSFRELNSLKSIDFSFNKIPIVCEQEFKPLQGKTLSFLSLADNQLYSRVSVDWNKCLNPFRNMVLETLDVSGNGWGVDIMRNFSNAINGSQIFSLVLTRHIMGSSFGFSNLKDPDYHTFAGLARSSMIQLDISHGYIFSLNFRIFETLQELKVLNLAYNKINSISRNAFYGLDNLQVLNISYNLLGELYNYDFDGLPKVAYIDLQKNHIGIIQDKTFKFLGKLNTLDLRDNALKTIYFLPSIPNIFLSGNKLMTLPNIPLTANFIQLSENRLENLNDLYFLLQVPHLQILILNQNRFSFCHQNHAPSENSSLEKLFLGENMLQLAWETGSCWDIFKGLSHLQLLYLNKNYLNFLPPGVFHHLTALRGLSLKDNRLTVLFPGDLPANLEILDISGNQLLSPDPDLFASLSAIDITHNNFICECELSAFIHWLNQTNITIAGSPADMYCMYPNSLAGVSIYSLSTESCEEEEVLESLKFSLFILVTVTLTLFLVITLAVTKFRGFCFICYKKAQSLLFKDPIKGRESDTYKYDAYLCFSSKDFEWVQNALLKHLDVQYHSQNRFNLCFEERDFMPGENHIANIQDAVWSSRKIVCLVSRHFLRDGWCLEAFSYAQSRCLADLNGALIMVVVGSLSQFHLMRHQSIRGFVQKRQYLRWPEDLQDVDWFLNKLSQCILKKEKERKKDSAIQLQNVTTIS", "length": 858, "header": "tr|Q2LDA0-1|Q2LDA0_BOVIN Isoform 1 of Toll-like receptor 5 OS=Bos taurus OX=9913 GN=TLR5 PE=3 SV=1 CANONICAL=Q2LDA0-1" }, "locus": { "chromosome": "16", "start_pos": 26603741, "end_pos": 26601168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116837.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116837.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078089.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078089.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.", "journal": "Genomics", "date": "2007-10", "authors": "Seabury C M, Cargill E J, Womack J E", "evidence": [ { "database": "RefSeq", "id": "NP_001035591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" } ], "reference": [ { "type": "PubMed", "id": "17719743", "url": "https://glygen.org/publication/PubMed/17719743" } ] }, { "title": "Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella.", "journal": "Veterinary research", "date": "2015-02-19", "authors": "Tahoun Amin, Jensen Kirsty, Corripio-Miyar Yolanda, McAteer Sean P, Corbishley Alexander, Mahajan Arvind, Brown Helen, Frew David, Aumeunier Aude, Smith David G E, McNeilly Tom N, Glass Elizabeth J, Gally David L", "evidence": [ { "database": "RefSeq", "id": "NP_001035591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035591" } ], "reference": [ { "type": "PubMed", "id": "25827709", "url": "https://glygen.org/publication/PubMed/25827709" } ] } ], "pathway": [ { "id": "bta:444870", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444870", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "interleukin-1 receptor binding", "id": "GO:0005149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005149", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "toll-like receptor signaling pathway", "id": "GO:0002224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" }, { "name": "toll-like receptor 5 signaling pathway", "id": "GO:0034146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034146", "evidence": [ { "database": "UniProtKB", "id": "Q2LDA0", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 595, "end_pos": 597, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2LDA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LDA0" }, { "id": "PS50104", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50104" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TIR", "eco_id": "ECO_0000259", "start_pos": 691, "end_pos": 836, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 472, "end_pos": 474 }, { "start_pos": 595, "end_pos": 597 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 853, "end_pos": 855 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIW3-1", "uniprot_ac": "Q2KIW3", "uniprot_id": "DYDC2_BOVIN", "mass": { "chemical_mass": 22148.0, "monoisotopic_mass": 22148.0 }, "refseq": { "ac": "NP_001039628", "name": "DPY30 domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039628" }, "gene_names": [ { "name": "DYDC2", "type": "recommended", "evidence": [ { "id": "Q2KIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3" } ] }, { "name": "DYDC2", "type": "synonym", "evidence": [ { "id": "NP_001039628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039628" } ] } ], "protein_names": [ { "name": "DPY30 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q2KIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3/entry#names_and_taxonomy" } ] }, { "name": "DPY30 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039628" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIW3", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYDC2", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3", "locus": { "chromosome": "28", "start_pos": 35755041, "end_pos": 35746027, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032862", "url": "https://www.ensembl.org/id/ENSBTAG00000032862" } ] } } ], "crossref": [ { "id": "Q2KIW3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032862", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032862", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22966", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22966", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514060", "url": "https://www.ncbi.nlm.nih.gov/gene/514060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AHWLYHH", "url": "https://omabrowser.org/oma/group/AHWLYHH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIW3", "url": "https://www.orthodb.org/?gene=Q2KIW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23356:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23356:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039628", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIW3", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIW3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METNYLKRCFGNRLAQALAEVAMVQPSDPIEYLAHWLYHYRKTAKAKEKDRQEKIQLQREYENSLKETRMAEMLKQEERAIQEQCEKCHYQLGRRNSAVGTHPHPVPLISVASSLEKTKFMQENTEAFEKEPLKQESLPGTSDMIPGMPQQSPSSEPSVSSQVDLNTGTPQEINYQAIQHEIALEIHPGSESPP", "length": 194, "header": "sp|Q2KIW3-1|DYDC2_BOVIN Isoform 1 of DPY30 domain-containing protein 2 OS=Bos taurus OX=9913 GN=DYDC2 PE=2 SV=1 CANONICAL=Q2KIW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR16-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3/entry#A0AAA9SR16-1", "sequence": { "sequence": "MLNLITSANSSLSYKPARMETNYLKRCFGNRLAQALAEVAMVQPSDPIEYLAHWLYHYRKTAKAKEKDRQEKIQLQREYENSLKETRMAEMLKQEERAIQEQCEKCHYQLGRRNSAVGTHPHPVPLISVASSLEKTKFMQENTEAFEKEPLKQESLPGTSDMIPGMPQQSPSSEPSVSSQVDLNTGTPQEINYQAIQHEIALEIHPGSESPP", "length": 212, "header": "tr|A0AAA9SR16-1|A0AAA9SR16_BOVIN Computationally mapped isoform of DPY30 domain-containing protein 2 OS=Bos taurus OX=9913 GN=DYDC2 PE=3 SV=1 CANONICAL=Q2KIW3-1" }, "locus": { "chromosome": "28", "start_pos": 35754778, "end_pos": 35747604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130844.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130844.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085405.1" } ] } }, { "isoform_ac": "Q2KIW3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3/entry#Q2KIW3-1", "sequence": { "sequence": "METNYLKRCFGNRLAQALAEVAMVQPSDPIEYLAHWLYHYRKTAKAKEKDRQEKIQLQREYENSLKETRMAEMLKQEERAIQEQCEKCHYQLGRRNSAVGTHPHPVPLISVASSLEKTKFMQENTEAFEKEPLKQESLPGTSDMIPGMPQQSPSSEPSVSSQVDLNTGTPQEINYQAIQHEIALEIHPGSESPP", "length": 194, "header": "sp|Q2KIW3-1|DYDC2_BOVIN Isoform 1 of DPY30 domain-containing protein 2 OS=Bos taurus OX=9913 GN=DYDC2 PE=2 SV=1 CANONICAL=Q2KIW3-1" }, "locus": { "chromosome": "28", "start_pos": 35754778, "end_pos": 35750747, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046653.3", "url": "https://www.ensembl.org/id/ENSBTAT00000046653.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000043930.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514060", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F8WFN8-1", "protein_name": "DPY30 domain containing 2", "gene_name": "Dydc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METAYLKKCFGNTLTQALAEVARVQPNDPIEYLAHWLYHHRNITKAEEKKKQEELQLQEVHDSNSKEAKATATLKEGSYQIKQKCEKRHQELPSTSVSSDQTPALQEDLALREEKSTRQEAPPGVSNVITKTPQSAIPS", "length": 139 }, "evidence": [ { "id": "Q2KIW3", "url": "https://omabrowser.org/oma/group/Q2KIW3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HQ16-1", "protein_name": "DPY30 domain-containing protein 2", "gene_name": "Dydc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METDYLKKCFGNSLTQALAEVARVRPSDPIEYLALLLYHYGNVNNDKEKKRQEELQLKEEHDRVLKEANMTQILKQEENQIQQNCEQCQQELLPKALSSNKTPALQEDTAPLEKETKSPESQPSVSSVIAEMPQRVFTS", "length": 139 }, "evidence": [ { "id": "Q2KIW3", "url": "https://omabrowser.org/oma/group/Q2KIW3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96IM9-1", "protein_name": "DPY30 domain-containing protein 2", "gene_name": "DYDC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METNYLKRCFGNCLAQALAEVAKVRPSDPIEYLAHWLYHYRKTAKAKEENREKKIHLQEEYDSSLKEMEMTEMLKQEEYQIQQNCEKCHKELTSETVSTKKTIFMQEDTNPLEKEALKQEFLPGTSSLIPGMPQQVPPSESAGQIDQNFKMPQEINYKEAFQHEVAHEMPPGSKSPF", "length": 177 }, "evidence": [ { "id": "Q2KIW3", "url": "https://omabrowser.org/oma/group/Q2KIW3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW3", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3" } ], "pmid": "" }, { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW3", "url": "https://www.uniprot.org/uniprotkb/Q2KIW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIW3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIW3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIW3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBR5-1", "uniprot_ac": "Q3ZBR5", "uniprot_id": "TTC1_BOVIN", "mass": { "chemical_mass": 33596.0, "monoisotopic_mass": 33596.0 }, "refseq": { "ac": "NP_001029389", "name": "tetratricopeptide repeat protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029389" }, "gene_names": [ { "name": "TTC1", "type": "recommended", "evidence": [ { "id": "Q3ZBR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ] }, { "name": "TTC1", "type": "synonym", "evidence": [ { "id": "NP_001029389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029389" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#names_and_taxonomy" } ] }, { "name": "TPR repeat protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029389" }, { "id": "Q3ZBR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029389" } ] } ], "function": [ { "annotation": "Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling. Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS. Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways. Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TYM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYM5#function" }, { "database": "UniProtKB", "id": "ARBA00094427", "url": "https://www.uniprot.org/uniprotkb/ARBA00094427#function" }, { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5#function" }, { "database": "UniProtKB", "id": "Q99614", "url": "https://www.uniprot.org/uniprotkb/Q99614#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5", "locus": { "chromosome": "7", "start_pos": 71647531, "end_pos": 71598641, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010321", "url": "https://www.ensembl.org/id/ENSBTAG00000010321" } ] } } ], "crossref": [ { "id": "Q3ZBR5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504602", "url": "https://www.ncbi.nlm.nih.gov/gene/504602", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504602", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504602", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KSAIDDC", "url": "https://omabrowser.org/oma/group/KSAIDDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBR5", "url": "https://www.orthodb.org/?gene=Q3ZBR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46014", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46014", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46014:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46014:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029389", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292, "header": "sp|Q3ZBR5-1|TTC1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 1 OS=Bos taurus OX=9913 GN=TTC1 PE=2 SV=1 CANONICAL=Q3ZBR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRW3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#A0AAA9SRW3-1", "sequence": { "sequence": "MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKEIT", "length": 183, "header": "tr|A0AAA9SRW3-1|A0AAA9SRW3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 1 OS=Bos taurus OX=9913 GN=TTC1 PE=4 SV=1 CANONICAL=Q3ZBR5-1" }, "locus": { "chromosome": "7", "start_pos": 71639597, "end_pos": 71599783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109608.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109608.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088113.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088113.1" } ] } }, { "isoform_ac": "A0AAA9TUV9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#A0AAA9TUV9-1", "sequence": { "sequence": "MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 224, "header": "tr|A0AAA9TUV9-1|A0AAA9TUV9_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 1 OS=Bos taurus OX=9913 GN=TTC1 PE=4 SV=1 CANONICAL=Q3ZBR5-1" }, "locus": { "chromosome": "7", "start_pos": 71647044, "end_pos": 71599783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092717.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092717.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101150.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101150.1" } ] } }, { "isoform_ac": "A0AAA9TYM5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#A0AAA9TYM5-1", "sequence": { "sequence": "MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSVHQAREACMVN", "length": 232, "header": "tr|A0AAA9TYM5-1|A0AAA9TYM5_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 1 OS=Bos taurus OX=9913 GN=TTC1 PE=4 SV=1 CANONICAL=Q3ZBR5-1" }, "locus": { "chromosome": "7", "start_pos": 71646919, "end_pos": 71599783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133597.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133597.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102339.1" } ] } }, { "isoform_ac": "Q3ZBR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5/entry#Q3ZBR5-1", "sequence": { "sequence": "MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292, "header": "sp|Q3ZBR5-1|TTC1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 1 OS=Bos taurus OX=9913 GN=TTC1 PE=2 SV=1 CANONICAL=Q3ZBR5-1" }, "locus": { "chromosome": "7", "start_pos": 71647044, "end_pos": 71599783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013634.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013634.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013634.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013634.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 90, "end_pos": 90, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ], "site_lbl": "Ser90" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504602", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504602", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AVJ6-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "TTC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEKSENCMVSEDMFNGLKVTDTHEAECVSPPVANAKDDHTQSKLHKDVEARPQEDQEEEECFHDSSASFEEEPGPNKVENKSDDDVNSSELDEEYLIELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQMCPSCFQKDRSILFSNRAAARMKQDKKEMAISDCSKAIQLNPNYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSVHQAREACMRLPKQIEDRNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MWJ9-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "Ttc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEKSENCKVPEDLFNGLKVTDSQEVESASPQVSDPKVQHSQSKLLKDDGAHSQEDHGEEECFHDCSASFEEEQPGAQMVGDKATDESGSSELDEEYLTELEKNMPEEEKQKRREESTKLKEQGNEQFKRGDYIEAESSYSQALQMCPSCFQKDRSVLFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKLILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNNR", "length": 294 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BWM0-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "TTC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEVKDGHPPEELLDHLKLSDQKSTESTSSWASGPKDAQNLPNLASGDIPSSAKDPTTADECFHDCRDSFEMKEPVLDDEESSQNDENSTRKQTELDEEYLLELEKDMPEEEKQKRRKESTTLKEKGNEQFKKGDYGEAEDSYTKALQICPACFQKDRAVLFSNRAAAKMKQDKTEAALNDCSKAVELDPNYIRALLRRAELHEKTEKLDEALEDYKAILEKDPSVHQAREACMRLPRQIEERNEKLKKEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 296 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q66H09-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "Ttc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGKSEDCKVPEDLFNGLKVTDSQETESASSLVSDPKDQHVQSKPLKDAEAHPQEDHGEEECFHDCSASFEEEQPGAHMAGDKASDESSSELEEEYLIELEKNMPEEEKQKRREESAKLKEEGNEQFKRGDYVEAESSYSQALQMCPACFQKDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQAREACVRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91Z38-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "Ttc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEKSEDCKVPEDLFNGLKVADPQEGESASPMVSDPKGQHCQSKLPKAAEAHPQDDHVEEECFHDCSASFEEEQPGAHVAGSKASDDSSSELDEEYLIELEKNMPEEEKQKRREESAKLKEEGNERFKRGDYMEAESSYSQALQMCPACFQKDRSVLFSNRAAARMKQDKKETAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSVLEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99614-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "TTC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR", "length": 292 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M0B2-1", "protein_name": "Tetratricopeptide repeat (TPR)-like superfamily protein", "gene_name": "TPR1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVLIESSESEDEILIKNEPKPASSSSPQPTETKQVDGDDSDGFETASEREISDEEGEEDGTKNDAVTSQEEPQHSEKKEEQIELMSEGEAIVDDGSNKEKALAEANEAKAEGNKLFVNGLYEEALSKYAFALELVQELPESIELRSICYLNRGVCFLKLGKCEETIKECTKALELNPTYNKALVRRAEAHEKLEHFEDAVTDLKKILELDPSNDQARKGIRRLEPLAAEKREKMKEEAITKLKEMGNSILGRFGMSVDNFKAVKDPNTGSYSLSFQN", "length": 277 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VEV3-1", "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "Ttc1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGNANSDDEFHDAIGEEITEKEATSTRQSEKDVDEIVEKQNQLALDDEAEQGAAGGDSIATPTTVDSELTIEELREREKDLSPEQLTANKEKADKLKVEGNELFKNDDAEGAAKTYTEALDICPSASSKERAVLYGNRAAAKIKLEANKAAIDDCTKAIELWPEYVRVLLRRAKLYEQEDKPDEALEDYKKVTEIDPGQQEAREAQIRLPPIINERNEKLKNEMMSSLKDLGNMILKPFGLSTQNFQMQQDPNTGSYSINFK", "length": 263 }, "evidence": [ { "id": "Q3ZBR5", "url": "https://omabrowser.org/oma/group/Q3ZBR5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of neuroinflammatory response", "id": "GO:0150078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150078", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBR5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 90 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9T4-1", "uniprot_ac": "Q5E9T4", "uniprot_id": "TPK1_BOVIN", "mass": { "chemical_mass": 27028.0, "monoisotopic_mass": 27028.0 }, "refseq": { "ac": "NP_001073839", "name": "thiamine pyrophosphokinase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073839" }, "gene_names": [ { "name": "TPK1", "type": "recommended", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ] }, { "name": "TPK1", "type": "synonym", "evidence": [ { "id": "NP_001073839", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073839" } ] } ], "protein_names": [ { "name": "Thiamine pyrophosphokinase 1", "type": "recommended", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#names_and_taxonomy" } ] }, { "name": "2.7.6.-", "type": "synonym", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#names_and_taxonomy" } ] }, { "name": "thiamine pyrophosphokinase 1", "type": "synonym", "evidence": [ { "id": "NP_001073839", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073839" } ] } ], "function": [ { "annotation": "Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ATF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF1#function" }, { "database": "UniProtKB", "id": "ARBA00055888", "url": "https://www.uniprot.org/uniprotkb/ARBA00055888#function" }, { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4#function" }, { "database": "UniProtKB", "id": "Q9H3S4", "url": "https://www.uniprot.org/uniprotkb/Q9H3S4#function" }, { "database": "UniProtKB", "id": "A0A3Q1M167", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M167#function" }, { "database": "UniProtKB", "id": "A0AAF6Z455", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z455#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPK1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4", "locus": { "chromosome": "4", "start_pos": 107718449, "end_pos": 108100582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017676", "url": "https://www.ensembl.org/id/ENSBTAG00000017676" } ] } } ], "crossref": [ { "id": "Q5E9T4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9T4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017676", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017676", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788066", "url": "https://www.ncbi.nlm.nih.gov/gene/788066", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788066", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788066", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TDMCKAL", "url": "https://omabrowser.org/oma/group/TDMCKAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M167", "url": "https://www.orthodb.org/?gene=A0A3Q1M167", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEU5", "url": "https://www.orthodb.org/?gene=A0A3Q1MEU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9T4", "url": "https://www.orthodb.org/?gene=Q5E9T4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13622", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13622", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13622:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13622:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196819", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196819", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001073839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073839", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "79423", "url": "https://www.rhea-db.org/rhea/79423", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M167", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M167", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M167-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M167-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEU5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z455", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z455", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z455-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z455-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKN", "length": 243, "header": "sp|Q5E9T4-1|TPK1_BOVIN Isoform 1 of Thiamine pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=2 SV=1 CANONICAL=Q5E9T4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M167-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0A3Q1M167-1", "sequence": { "sequence": "MEHAITPLDPLLPSALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKN", "length": 219, "header": "tr|A0A3Q1M167-1|A0A3Q1M167_BOVIN Computationally mapped isoform of Thiamine pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=3 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107719283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068486.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068486.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067023.1" } ] } }, { "isoform_ac": "A0A3Q1MEU5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0A3Q1MEU5-1", "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLNDLPSFRLKQSGAIERVTCRADGVPET", "length": 231, "header": "tr|A0A3Q1MEU5-1|A0A3Q1MEU5_BOVIN Computationally mapped isoform of Thiamine pyrophosphokinase OS=Bos taurus OX=9913 GN=TPK1 PE=3 SV=2 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107802486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075107.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075107.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069030.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069030.2" } ] } }, { "isoform_ac": "A0AAA9SUE0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0AAA9SUE0-1", "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLIPYEVAIKALMRSGKRTRLRRLWLGSCVGSHVHPLVSWMACDAVHHMAVAEHHEGGCPVSSFQFYRLLLKVLTLQKSSRVRLEVGDGDD", "length": 293, "header": "tr|A0AAA9SUE0-1|A0AAA9SUE0_BOVIN Computationally mapped isoform of Thiamin pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=4 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107811219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092235.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092235.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087762.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087762.1" } ] } }, { "isoform_ac": "A0AAA9TBG9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0AAA9TBG9-1", "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLRAPVENPFQTISAFRSCPRFLTHDSFFHCQGRQHSSIRSLTSFYTITSPSLTQT", "length": 258, "header": "tr|A0AAA9TBG9-1|A0AAA9TBG9_BOVIN Computationally mapped isoform of Thiamin pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=4 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107815660, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096893.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096893.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093433.1" } ] } }, { "isoform_ac": "A0AAF6Z455-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0AAF6Z455-1", "sequence": { "sequence": "ACKRPHPLDPSRSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKN", "length": 240, "header": "tr|A0AAF6Z455-1|A0AAF6Z455_BOVIN Computationally mapped isoform of Thiamine pyrophosphokinase OS=Bos taurus OX=9913 GN=TPK1 PE=3 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108018981, "end_pos": 107719283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023510.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023510.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023510.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023510.4" } ] } }, { "isoform_ac": "A0AAF7ATF1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#A0AAF7ATF1-1", "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKN", "length": 194, "header": "tr|A0AAF7ATF1-1|A0AAF7ATF1_BOVIN Computationally mapped isoform of Thiamine pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=3 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107719283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066366.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066366.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074589.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074589.2" } ] } }, { "isoform_ac": "Q5E9T4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4/entry#Q5E9T4-1", "sequence": { "sequence": "MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGERESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVDMIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEGDWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKN", "length": 243, "header": "sp|Q5E9T4-1|TPK1_BOVIN Isoform 1 of Thiamine pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=TPK1 PE=2 SV=1 CANONICAL=Q5E9T4-1" }, "locus": { "chromosome": "4", "start_pos": 108100060, "end_pos": 107719283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044036.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044036.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041553.1", "url": "https://www.ensembl.org/id/ENSBTAP00000041553.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:788066", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788066", "resource": "KEGG Pathway" }, { "id": "R-BTA-196819", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196819", "resource": "Reactome", "description": "Vitamin B1 (thiamin) metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "B5DEJ6-1", "protein_name": "Thiamine pyrophosphokinase", "gene_name": "Tpk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEHVFTPLEPLLPTGDLKFCLVVLNQTLDPHFRHLWRKALLRACADGGANHLYDLTEGERESFLPEFINGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCLQVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQATDIIPVPIIIIQKESLIYLLQPGKHRLRVDTGMEGSWCGLIPVGQPCNHVTTTGLKWNLTNDVLGFGTLVSTSNTYDGSGLVTVETDHPLLWTMAIKT", "length": 243 }, "evidence": [ { "id": "Q5E9T4", "url": "https://omabrowser.org/oma/group/Q5E9T4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B9DGU7-1", "protein_name": "Thiamine pyrophosphokinase 1", "gene_name": "TPK1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSAMDVMIHSSSFLLPCDETSTGTRYALVVLNQSLPRFTPLLWEHAKLRLCADGGANRIYDELPLFFPNEDALAIRNRYKPDVIKGDMDSIRRDVLDFYINLGTKVIDESHDQDTTDLDKCILYIRHSTLNQETSGLQILATGALGGRFDHEAGNLNVLYRYPDTRIVLLSDDCLIQLLPKTHRHEIHIQSSLEGPHCGLIPIGTPSAKTTTSGLQWDLSNTEMRFGGLISTSNLVKEEKITVESDSDLLWTISIKKTGLSIQDHTP", "length": 267 }, "evidence": [ { "id": "Q5E9T4", "url": "https://omabrowser.org/oma/group/Q5E9T4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3HW81-1", "protein_name": "Thiamine pyrophosphokinase", "gene_name": "Tpk1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEHAFTPLEPLLPTGNLKYCLMVLNQPLDTRFRHLWKKALFRACADGGANCLYDLTEGERERFLPEFISGDFDSIRPEVREYYTEKGCDLISTPDQDHTDFTKCLKVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQAPHITPVPIIIIQGESLIYLLQPGKHRLHVDTGMEGSWCGLIPVGQRCSQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAVKS", "length": 243 }, "evidence": [ { "id": "Q5E9T4", "url": "https://omabrowser.org/oma/group/Q5E9T4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P35202-1", "protein_name": "Thiamine pyrophosphokinase", "gene_name": "THI80", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL", "length": 319 }, "evidence": [ { "id": "Q5E9T4", "url": "https://omabrowser.org/oma/group/Q5E9T4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9R0M5-1", "protein_name": "Thiamine pyrophosphokinase 1", "gene_name": "Tpk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEHAFTPLEPLLPTGNLKYCLVVLNQPLDARFRHLWKKALLRACADGGANHLYDLTEGERESFLPEFVSGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCLQVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQATHITPVPIIIIQKDSLIYLLQPGKHRLHVDTGMEGSWCGLIPVGQPCNQVTTTGLKWNLTNDVLGFGTLVSTSNTYDGSGLVTVETDHPLLWTMAIKS", "length": 243 }, "evidence": [ { "id": "Q5E9T4", "url": "https://omabrowser.org/oma/group/Q5E9T4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "thiamine diphosphokinase activity", "id": "GO:0004788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004788", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "thiamine binding", "id": "GO:0030975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030975", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "UTP thiamine diphosphokinase activity", "id": "GO:0141200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141200", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "thiamine diphosphate biosynthetic process", "id": "GO:0009229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009229", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "thiamine metabolic process", "id": "GO:0006772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006772", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" }, { "name": "regulation of pyruvate decarboxylation to acetyl-CoA", "id": "GO:0010510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010510", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T4", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "79423", "name": "", "equation": "thiamine + UTP = thiamine diphosphate + UMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9T4-1" ], "evidence": [ { "id": "79423", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79423" } ] }, { "id": "R-BTA-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-196934" ], "output_participant_list": [ "R-ALL-29480" ], "enzyme_list": [ "Q5E9T4-1" ], "evidence": [ { "id": "R-BTA-196761", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196761" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-196934", "participant_name": "THMN [cytosol]", "crossref": [ { "id": "18385", "database": "ChEBI", "url": "" }, { "id": "C00378", "database": "COMPOUND", "url": "" }, { "id": "ZINC000000049153", "database": "ZINC", "url": "" }, { "id": "HMDB0000235", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-29480", "participant_name": "ThDP [cytosol]", "crossref": [ { "id": "ZINC000008215517", "database": "ZINC", "url": "" }, { "id": "C00068", "database": "COMPOUND", "url": "" }, { "id": "58937", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5E9T4", "gene_name": "TPK1", "activity": [ { "ec_number": "2.7.6.2", "activity": "thiamine + ATP = thiamine diphosphate + AMP + H(+).", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ] }, { "ec_number": "2.7.6.2", "activity": "", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ] }, { "ec_number": "2.7.6.-", "activity": "", "evidence": [ { "id": "Q5E9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9T4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 243, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9T4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9T4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.6.2", "ec_name": "thiamine + ATP = thiamine diphosphate + AMP + H(+).", "evidence": [ { "id": "2.7.6.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.2" }, { "id": "2.7.6.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.6.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E997-1", "uniprot_ac": "Q5E997", "uniprot_id": "CAZA2_BOVIN", "mass": { "chemical_mass": 32979.0, "monoisotopic_mass": 32979.0 }, "refseq": { "ac": "NP_001013016", "name": "F-actin-capping protein subunit alpha-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" }, "gene_names": [ { "name": "CAPZA2", "type": "recommended", "evidence": [ { "id": "Q5E997", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ] }, { "name": "CAPZA2", "type": "synonym", "evidence": [ { "id": "NP_001013016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" } ] } ], "protein_names": [ { "name": "F-actin-capping protein subunit alpha-2", "type": "recommended", "evidence": [ { "id": "Q5E997", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#names_and_taxonomy" } ] }, { "name": "CapZ alpha-2", "type": "synonym", "evidence": [ { "id": "Q5E997", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#names_and_taxonomy" } ] }, { "name": "F-actin-capping protein subunit alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001013016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" } ] }, { "name": "capZ alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001013016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" } ] }, { "name": "capping actin protein of muscle Z-line alpha subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001013016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" } ] }, { "name": "capping protein (actin filament) muscle Z-line, alpha 2", "type": "synonym", "evidence": [ { "id": "NP_001013016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016" } ] } ], "function": [ { "annotation": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997#function" }, { "database": "UniProtKB", "id": "A0AAA9SUK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK1#function" }, { "database": "UniProtKB", "id": "RU365077", "url": "https://www.uniprot.org/uniprotkb/RU365077#function" }, { "database": "UniProtKB", "id": "ARBA00025389", "url": "https://www.uniprot.org/uniprotkb/ARBA00025389#function" }, { "database": "UniProtKB", "id": "A0A3Q1LXG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXG3#function" }, { "database": "UniProtKB", "id": "A0A3Q1M698", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M698#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAPZA2", "url": "https://www.uniprot.org/uniprotkb/Q5E997", "locus": { "chromosome": "4", "start_pos": 51491712, "end_pos": 51546693, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004072", "url": "https://www.ensembl.org/id/ENSBTAG00000004072" } ] } } ], "crossref": [ { "id": "Q5E997", "url": "https://alphafold.ebi.ac.uk/entry/Q5E997", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004072", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004072", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "493728", "url": "https://www.ncbi.nlm.nih.gov/gene/493728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3RM1", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3RM1&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "Q5E997", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q5E997*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:493728", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:493728", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VACIEDH", "url": "https://omabrowser.org/oma/group/VACIEDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXG3", "url": "https://www.orthodb.org/?gene=A0A3Q1LXG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M698", "url": "https://www.orthodb.org/?gene=A0A3Q1M698", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E997", "url": "https://www.orthodb.org/?gene=Q5E997", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10653", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10653", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10653:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10653:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003rm1", "url": "https://www.rcsb.org/structure/pdb_00003rm1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3RM1", "url": "https://www.rcsb.org/structure/3RM1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01267", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01267", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-879415", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879415", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001013016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013016", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M698", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M698", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M698-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M698-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E997-1", "url": "https://www.uniprot.org/uniprotkb/Q5E997-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRISFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286, "header": "sp|Q5E997-1|CAZA2_BOVIN Isoform 1 of F-actin-capping protein subunit alpha-2 OS=Bos taurus OX=9913 GN=CAPZA2 PE=1 SV=3 CANONICAL=Q5E997-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXG3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#A0A3Q1LXG3-1", "sequence": { "sequence": "MQETWVQSPGEGNDSPLQHSCVEKATDRGAWQAIVHGVTKSLCYRTFISSFLFQVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRISFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 327, "header": "tr|A0A3Q1LXG3-1|A0A3Q1LXG3_BOVIN Computationally mapped isoform of F-actin-capping protein subunit alpha OS=Bos taurus OX=9913 GN=CAPZA2 PE=3 SV=1 CANONICAL=Q5E997-1" }, "locus": { "chromosome": "4", "start_pos": 51520037, "end_pos": 51492376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081990.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081990.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065455.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065455.1" } ] } }, { "isoform_ac": "A0A3Q1M698-1", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#A0A3Q1M698-1", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRISFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 265, "header": "tr|A0A3Q1M698-1|A0A3Q1M698_BOVIN Computationally mapped isoform of F-actin-capping protein subunit alpha OS=Bos taurus OX=9913 GN=CAPZA2 PE=3 SV=2 CANONICAL=Q5E997-1" }, "locus": { "chromosome": "4", "start_pos": 51546632, "end_pos": 51492376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079935.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079935.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065495.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065495.2" } ] } }, { "isoform_ac": "A0AAA9SUK1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#A0AAA9SUK1-1", "sequence": { "sequence": "ARPCVRVGNCRRVWVPAWKRPKDSTQPEGLAGVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRISFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 305, "header": "tr|A0AAA9SUK1-1|A0AAA9SUK1_BOVIN Computationally mapped isoform of F-actin-capping protein subunit alpha OS=Bos taurus OX=9913 GN=CAPZA2 PE=3 SV=1 CANONICAL=Q5E997-1" }, "locus": { "chromosome": "4", "start_pos": 51546261, "end_pos": 51492376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106527.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106527.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086827.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086827.1" } ] } }, { "isoform_ac": "Q5E997-1", "url": "https://www.uniprot.org/uniprotkb/Q5E997/entry#Q5E997-1", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRISFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286, "header": "sp|Q5E997-1|CAZA2_BOVIN Isoform 1 of F-actin-capping protein subunit alpha-2 OS=Bos taurus OX=9913 GN=CAPZA2 PE=1 SV=3 CANONICAL=Q5E997-1" }, "locus": { "chromosome": "4", "start_pos": 51546632, "end_pos": 51492376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005324.4", "url": "https://www.ensembl.org/id/ENSBTAT00000005324.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005324.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005324.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Comparative analyses of multi-species sequences from targeted genomic regions.", "journal": "Nature", "date": "2003", "authors": "Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin SQ, Maduro VV, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho SL, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang LH, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler D, Green P, Miller W, Green ED", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "reference": [ { "type": "PubMed", "id": "12917688", "url": "https://glygen.org/publication/PubMed/12917688" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:493728", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:493728", "resource": "KEGG Pathway" }, { "id": "R-BTA-879415", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879415", "resource": "Reactome", "description": "Advanced glycosylation endproduct receptor signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "O82631-1", "protein_name": "F-actin-capping protein subunit alpha", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADEEDELLETELSYDQKKEIAKWFFLNAPAGEINYVAKDLKAVLSDEEVYNEAAMEAFPVYNKTHMICLEMPSGAGDVIVSSYSEINENEYLDPRTAQVAIVDHVKQICTKVRPANDEELPSLYIEEYRYALDAEIQRYVSESYPKGMSAVNCVKGKDNEGPGSDFELVVIITAMRLSPQNFCNGSWRSVWNIDFQDESQVLDIKGKLQVGAHYFEEGNVELDAKKDFQDSTIFQSADDCAIAIANIIRHHETEYLASLEVAYSKLPDNTFKDLRRKLPVTRTLFPWQNTLQFSLTREVEKELGLGK", "length": 308 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P13022-1", "protein_name": "F-actin-capping protein subunit alpha", "gene_name": "acpB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MASNQELVQIATNFLLNAPPCEFMEVVSDVRALLPSESLLNASAGSTFREYNTSQMVSVQTSKGSALITKEGEISNNEYLDPKNKQVITYDHIKQEVTGERSASGEIEQDIEQYRAAFDEEATKYCNEYYPNGVSAVYGTKVSEGIKITVCISTCIYKPNAFYSGRWRSVWTCTFKPGSGNVTSNGKVQVNVHYFEDGNVQLNTVTQKQTTSPSADAQSTAVNAFKAIGKAELNLHTALDNNYSTMGDTTFKALRRALPINRTKINWQKVKNFKIANELNK", "length": 281 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P28495-1", "protein_name": "F-actin-capping protein subunit alpha", "gene_name": "CAP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSSKFEEVINKIINDSPPGELREVYDDLIKITSENSKNTILDAIENYNVQNCIPIEVNGNSVIISKYNKEGAKFFDPVNSVIFSVNHLERKGLDIEPYEFTHAKIEKGQLKELHDKLHEYLLQSFPGDVSFAVYPVPEEISKISIIIVSTKYNPNNFWNGHWRSSYIYDLETRELSGQISTQVHYYEDGNVSFQSGKDINQSNVDDVVCTIRDIETNFENDLDLSFFDLNEKQFKALRRRLPVTRSKINWGSAIGSYRLGKNAAEGK", "length": 268 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P28497-1", "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "CAPZA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIDGYDEQVLITEHGDLGNGKFLDPKNKISFKFDHLRKEATDPRPHEVENAIESWRNSVETAMKAYVKEHYPNGVCTVYGKTIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTISPSTTQVAGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEAQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P47754-1", "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "Capza2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P47755-1", "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "CAPZA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q29221-1", "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "CAPZA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3T1K5-1", "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "Capza2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9W2N0-1", "protein_name": "F-actin-capping protein subunit alpha", "gene_name": "cpa", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEQTPITDAEKVRIVSDFILHAPPGEFNEVFNDVRELLKNDTLLKDGASHAFAQYNKDQLTPVRIEGTDHNAIISEHNDLGNGRFYDPRTKQAFKYDHLRKEASDYQDVEADATAEPWRAALDLETLAYTASHYRHGVSSVFGKAQGNQITLTICIEDHQFQPKNYWNGRWRSQWHVTFQAGSGTAELKGVLKVQVHYYEDGNVQLVSSKECRESVVVSNEQQVAKEVIRLIEDAENEYQLAISENYQTMSDTTFKAMRRQLPITRTKIDWSKIVSYSIGKELKTQ", "length": 286 }, "evidence": [ { "id": "Q5E997", "url": "https://omabrowser.org/oma/group/Q5E997/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "F-actin capping protein complex", "id": "GO:0008290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008290", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "cortical cytoskeleton", "id": "GO:0030863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030863", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" }, { "name": "barbed-end actin filament capping", "id": "GO:0051016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051016", "evidence": [ { "database": "UniProtKB", "id": "Q5E997", "url": "https://www.uniprot.org/uniprotkb/Q5E997" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E997-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 286, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E997-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E997" }, { "pdb_id": "3rm1", "pdb_chain": "b", "start_pos": 267, "end_pos": 275, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/3rm1.pdb", "url_external": "https://www.rcsb.org/structure/3rm1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBE6-1", "uniprot_ac": "Q3ZBE6", "uniprot_id": "TM135_BOVIN", "mass": { "chemical_mass": 52269.0, "monoisotopic_mass": 52269.0 }, "refseq": { "ac": "NP_001030425", "name": "transmembrane protein 135", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030425" }, "gene_names": [ { "name": "TMEM135", "type": "recommended", "evidence": [ { "id": "Q3ZBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ] }, { "name": "TMEM135", "type": "synonym", "evidence": [ { "id": "NP_001030425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030425" } ] } ], "protein_names": [ { "name": "Transmembrane protein 135", "type": "recommended", "evidence": [ { "id": "Q3ZBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 135", "type": "synonym", "evidence": [ { "id": "NP_001030425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030425" } ] } ], "function": [ { "annotation": "Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6#function" }, { "database": "UniProtKB", "id": "Q5U4F4", "url": "https://www.uniprot.org/uniprotkb/Q5U4F4#function" }, { "database": "UniProtKB", "id": "Q9CYV5", "url": "https://www.uniprot.org/uniprotkb/Q9CYV5#function" }, { "database": "UniProtKB", "id": "F1N3X4", "url": "https://www.uniprot.org/uniprotkb/F1N3X4#function" }, { "database": "UniProtKB", "id": "ARBA00045417", "url": "https://www.uniprot.org/uniprotkb/ARBA00045417#function" }, { "database": "UniProtKB", "id": "A0AAA9SV12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV12#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM135", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6", "locus": { "chromosome": "29", "start_pos": 8237271, "end_pos": 8540197, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005482", "url": "https://www.ensembl.org/id/ENSBTAG00000005482" } ] } } ], "crossref": [ { "id": "Q3ZBE6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005482", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005482", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523885", "url": "https://www.ncbi.nlm.nih.gov/gene/523885", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523885", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523885", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HPWTDKC", "url": "https://omabrowser.org/oma/group/HPWTDKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3X4", "url": "https://www.orthodb.org/?gene=F1N3X4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBE6", "url": "https://www.orthodb.org/?gene=Q3ZBE6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12459", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12459", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12459:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12459:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15982", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15982", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SV12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3X4", "url": "https://www.uniprot.org/uniprotkb/F1N3X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3X4-1", "url": "https://www.uniprot.org/uniprotkb/F1N3X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWQPSCWLSFLHITRGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALFMAFFCILRKILGKFYLWSPGFGAALPASYVAILVERKSRRGLLTIYMANLATETLFRMGVARGVITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPEAAYAKVEQKTEKHEEKPRGMNIIALVRKLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIIAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGRFAVMNRKVLDVFGTGASKNFPDFTPRLDPRYTTVTPELPIEFS", "length": 458, "header": "sp|Q3ZBE6-1|TM135_BOVIN Isoform 1 of Transmembrane protein 135 OS=Bos taurus OX=9913 GN=TMEM135 PE=2 SV=1 CANONICAL=Q3ZBE6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV12-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6/entry#A0AAA9SV12-1", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWQPSCWLSFLHITRGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALFMAFFCILRKILGKFYLWSPGFGAALPASYVAILVERKSRRGLLTIYMANLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPEAAYAKVEQKTEKHEEKPRGMNIIALVRKLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIIAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGRFAVMNRKVLDVFGTGASKNFPDFTPRLDPRYTTVTPELPIEFS", "length": 436, "header": "tr|A0AAA9SV12-1|A0AAA9SV12_BOVIN Computationally mapped isoform of Transmembrane protein 135 OS=Bos taurus OX=9913 GN=TMEM135 PE=3 SV=1 CANONICAL=Q3ZBE6-1" }, "locus": { "chromosome": "29", "start_pos": 8540089, "end_pos": 8239119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089178.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089178.1" } ] } }, { "isoform_ac": "A0AAA9T6M4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6/entry#A0AAA9T6M4-1", "sequence": { "sequence": "TKSATETLFRMGVARGVITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPEAAYAKVEQKTEKHEEKPRGMNIIALVRKLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIIAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGRFAVMNRKVLDVFGTGASKNFPDFTPRLDPRYTTVTPELPIEFS", "length": 329, "header": "tr|A0AAA9T6M4-1|A0AAA9T6M4_BOVIN Computationally mapped isoform of Transmembrane protein 135 OS=Bos taurus OX=9913 GN=TMEM135 PE=4 SV=1 CANONICAL=Q3ZBE6-1" }, "locus": { "chromosome": "29", "start_pos": 8540052, "end_pos": 8239119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132068.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132068.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092234.1" } ] } }, { "isoform_ac": "F1N3X4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6/entry#F1N3X4-1", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWQPSCWLSFLHITRGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALFMAFFCILRKILGKFYLWSPGFGAALPASYVAILVERKSRRGLLTIYMANLATETLFRMVYFLIDFFLRFIVGKEEIPTHSYSPEAAYAKVEQKTEKHEEKPRGMNIIALVRKLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIIAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGRFAVMNRKVLDVFGTGASKNFPDFTPRLDPRYTTVTPELPIEFS", "length": 424, "header": "tr|F1N3X4-1|F1N3X4_BOVIN Computationally mapped isoform of Transmembrane protein 135 OS=Bos taurus OX=9913 GN=TMEM135 PE=3 SV=3 CANONICAL=Q3ZBE6-1" }, "locus": { "chromosome": "29", "start_pos": 8540089, "end_pos": 8239119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007209.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007209.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007209.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007209.6" } ] } }, { "isoform_ac": "Q3ZBE6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6/entry#Q3ZBE6-1", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWQPSCWLSFLHITRGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALFMAFFCILRKILGKFYLWSPGFGAALPASYVAILVERKSRRGLLTIYMANLATETLFRMGVARGVITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPEAAYAKVEQKTEKHEEKPRGMNIIALVRKLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIIAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGRFAVMNRKVLDVFGTGASKNFPDFTPRLDPRYTTVTPELPIEFS", "length": 458, "header": "sp|Q3ZBE6-1|TM135_BOVIN Isoform 1 of Transmembrane protein 135 OS=Bos taurus OX=9913 GN=TMEM135 PE=2 SV=1 CANONICAL=Q3ZBE6-1" }, "locus": { "chromosome": "29", "start_pos": 8540089, "end_pos": 8239119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085727.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085727.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074445.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523885", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523885", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U3R4-1", "protein_name": "Transmembrane protein 135", "gene_name": "TMEM135", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWHPSCRVAFVQITRGALEESLRIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWSPGFGAALPASYVAILIERKSRRGLLTIYMANLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPEAAYARVEQKTEKHEEKLRRMNIIALVRKLVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAVIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQNLRPSYWKFLLRLTKGKFNVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPIEFS", "length": 436 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y1H9-1", "protein_name": "Transmembrane protein 135", "gene_name": "TMEM135", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALSKSIPHSCYEIGHTWHPRCSVAVLHVTQGALAESLRIYGTLYLIAAILRKRKLDYYLHKLLPEILQSTSFLTANGTLYIACFCILRKLLGKFYFWSPGFGAALPASYMAILIERKSRRGLLTIYMANQATETLFRMAVARGAIKPLRHGEVLLFCITSALFMFFFRCKDGLKGFTYSALKFIVGKEEIPTHSFSPEAAFSKTERKIKPCEKISQRMNLLALTKKLMDKVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSIGYLIQCCLRIPSTFRHLFTKPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHALVAGCLAGISMMFYKSTTISMYLASKLVETIYFKGIEAGKVPYFPHADSVIYAISTSICFQAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKVLDVFGTEASRNFKDFTPKLDPRYTVVPPELPLELS", "length": 458 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5U4F4-1", "protein_name": "Transmembrane protein 135", "gene_name": "Tmem135", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWNPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCVLRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHRGTTRAMSLIALVRSLVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVTPELPIDFS", "length": 458 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86UB9-1", "protein_name": "Transmembrane protein 135", "gene_name": "TMEM135", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPTEFS", "length": 458 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CYV5-1", "protein_name": "Transmembrane protein 135", "gene_name": "Tmem135", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALSKSIPHNCYEIGHTWHPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHKGTPRAMSIIALVRTLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVTPELPIDFS", "length": 458 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VHQ5-1", "protein_name": "Transmembrane protein 135 N-terminal domain-containing protein", "gene_name": "Dmel\\CG11737", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGQSKLIDPLCITCKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDDLRKTLLGIIQSTAFLVTNAYTFILYNCALRHMLGRYNFYTVAFVPCFLASFSAILVERPARRPLLTLYVANVATEALWKMAESRGWVRSVPNGQTLIFGVSMAALLYIYRTGTTKDSIFNILRIFVGKEEAGPIVKSGPAVPGEQPAPDRRRPTVSFSTVSDWVRVYSNLIRAKHESCRHQQSCIGYSLMGGIKPFVGGVGLQVALKLVMNVKRITAGKMPWKKMIFNRGTLQLGIFMGSFSFLYKSVSCLLRHSFNRDDARFAIPASLIASISFTQYPDNTVALYVMWKALQILCTKGQEHGIVPHIPNFMLFLYSFFTAVLFHAGILEPKSLRPSYYKFLQAISGDRLSKFNLSAFDVFGLSSQQQALDTIKALNIVEKSSLPAYSFAS", "length": 455 }, "evidence": [ { "id": "Q3ZBE6", "url": "https://omabrowser.org/oma/group/Q3ZBE6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of mitochondrial fission", "id": "GO:0090140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090140", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBE6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 458, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBE6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBE6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Q1-1", "uniprot_ac": "Q2T9Q1", "uniprot_id": "TBC20_BOVIN", "mass": { "chemical_mass": 45913.0, "monoisotopic_mass": 45913.0 }, "refseq": { "ac": "NP_001033118", "name": "TBC1 domain family member 20", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033118" }, "gene_names": [ { "name": "TBC1D20", "type": "recommended", "evidence": [ { "id": "Q2T9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ] }, { "name": "TBC1D20", "type": "synonym", "evidence": [ { "id": "NP_001033118", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033118" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 20", "type": "recommended", "evidence": [ { "id": "Q2T9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 20", "type": "synonym", "evidence": [ { "id": "NP_001033118", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033118" } ] } ], "function": [ { "annotation": "GTPase-activating protein (GAP) specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. Also shows GAP activity for RAB18 GTPase. Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis. Involved in maintaining endoplasmic reticulum structure.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1#function" }, { "database": "UniProtKB", "id": "Q96BZ9", "url": "https://www.uniprot.org/uniprotkb/Q96BZ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D20", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1", "locus": { "chromosome": "13", "start_pos": 60600669, "end_pos": 60581690, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013330", "url": "https://www.ensembl.org/id/ENSBTAG00000013330" } ] } } ], "crossref": [ { "id": "Q2T9Q1", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013330", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013330", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504543", "url": "https://www.ncbi.nlm.nih.gov/gene/504543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504543", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504543", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYMFAQI", "url": "https://omabrowser.org/oma/group/VYMFAQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9Q1", "url": "https://www.orthodb.org/?gene=Q2T9Q1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20913:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20913:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033118", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SW65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9H2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9H2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9H2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Q1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRSARGDGPTSGRWDGGAEKGDFNAKRKKKVAEIYQALNSEPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNTNDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVLGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQPQAEKTAASTFKDFELASAQQRPDMVLRQRFRGLLRPDERTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 403, "header": "sp|Q2T9Q1-1|TBC20_BOVIN Isoform 1 of TBC1 domain family member 20 OS=Bos taurus OX=9913 GN=TBC1D20 PE=2 SV=1 CANONICAL=Q2T9Q1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW65-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1/entry#A0AAA9SW65-1", "sequence": { "sequence": "MALRSARGDGPTSGRWDGGAEKGDFNAKRKKKVAEIYQALNSEPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNTNDPPPISGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVLGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQPQAEKTAASTFKDFELASAQQRPDMVLRQRFRGLLRPDERTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 376, "header": "tr|A0AAA9SW65-1|A0AAA9SW65_BOVIN Computationally mapped isoform of TBC1 domain family member 20 OS=Bos taurus OX=9913 GN=TBC1D20 PE=4 SV=1 CANONICAL=Q2T9Q1-1" }, "locus": { "chromosome": "13", "start_pos": 60598637, "end_pos": 60581794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091565.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091565.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089568.1" } ] } }, { "isoform_ac": "A0AAA9T9H2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1/entry#A0AAA9T9H2-1", "sequence": { "sequence": "MALRSARGDGPTSGRWDGGAEKGGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVLGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQPQAEKTAASTFKDFELASAQQRPDMVLRQRFRGLLRPDERTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 341, "header": "tr|A0AAA9T9H2-1|A0AAA9T9H2_BOVIN Computationally mapped isoform of TBC1 domain family member 20 OS=Bos taurus OX=9913 GN=TBC1D20 PE=4 SV=1 CANONICAL=Q2T9Q1-1" }, "locus": { "chromosome": "13", "start_pos": 60598637, "end_pos": 60581794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096981.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096981.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094644.1" } ] } }, { "isoform_ac": "Q2T9Q1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1/entry#Q2T9Q1-1", "sequence": { "sequence": "MALRSARGDGPTSGRWDGGAEKGDFNAKRKKKVAEIYQALNSEPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNTNDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVLGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQPQAEKTAASTFKDFELASAQQRPDMVLRQRFRGLLRPDERTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 403, "header": "sp|Q2T9Q1-1|TBC20_BOVIN Isoform 1 of TBC1 domain family member 20 OS=Bos taurus OX=9913 GN=TBC1D20 PE=2 SV=1 CANONICAL=Q2T9Q1-1" }, "locus": { "chromosome": "13", "start_pos": 60598637, "end_pos": 60581794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017725.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017725.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017725.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017725.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 12, "start_aa": "Thr", "end_pos": 12, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr12", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504543", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504543", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A634-1", "protein_name": "TBC1 domain family member 20", "gene_name": "TBC1D20", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALRSAQGDGPTSPRWDGGAEKADFNAKKKKKVAEIYQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNTSDPPPTSGKNLRQLSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 403 }, "evidence": [ { "id": "Q2T9Q1", "url": "https://omabrowser.org/oma/group/Q2T9Q1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M8N8-1", "protein_name": "TBC1 domain family member 20", "gene_name": "Tbc1d20", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALRPSQGDGSAGRWNCGLGKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRCQVWPKLLNVNTCEPPPVSRKDLRQLSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLILDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPETRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 402 }, "evidence": [ { "id": "Q2T9Q1", "url": "https://omabrowser.org/oma/group/Q2T9Q1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54RT5-1", "protein_name": "RabGAP/TBC domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFTDRERLEAQKIRVIKDCLNETPIDIEGLKRCSVEEFGFVNKVLRKRIWPLLLNIDTNNIINHSEKIINHKDTDQVTKDVERSMWRFTKGNSQLRNRKKPELTRIVNAVLSIHPQLYYFQGYHEIASVLLLISDESLAFAMLERLSIYHFNDCMLPNFAEVLKVLNLIFPLISMVDQHVYNFIIKSQVQPMFAISWILTWFSHNLDELDTAARVYDYLLSAHPMASIYLSVCVITSQRETLLNLECSFDSIHAFFTSNLPELDFDKIIKQTDSLLEKITPSKLQSSSKVYLLPESQLNRYPYDWMIFNNNNTTTNSKSSKLITNNKGTNQKRQQIYKFIFFILFGSISLFGTFVFLSIKSPNTFKHINSFLSPLLFNLFNNRFNQNNITNGETVSNFNQ", "length": 400 }, "evidence": [ { "id": "Q2T9Q1", "url": "https://omabrowser.org/oma/group/Q2T9Q1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q96BZ9-1", "protein_name": "TBC1 domain family member 20", "gene_name": "TBC1D20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 403 }, "evidence": [ { "id": "Q2T9Q1", "url": "https://omabrowser.org/oma/group/Q2T9Q1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9I4-1", "protein_name": "TBC1 domain family member 20", "gene_name": "Tbc1d20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRPSKGDGSAGRWDRGAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLLTDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP", "length": 402 }, "evidence": [ { "id": "Q2T9Q1", "url": "https://omabrowser.org/oma/group/Q2T9Q1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation by virus of viral protein levels in host cell", "id": "GO:0046726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046726", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "host-mediated activation of viral genome replication", "id": "GO:0044829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044829", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "COPII-coated vesicle cargo loading", "id": "GO:0090110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090110", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "positive regulation of ER to Golgi vesicle-mediated transport", "id": "GO:1902953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902953", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "virion assembly", "id": "GO:0019068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019068", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "vesicle organization", "id": "GO:0016050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016050", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Q1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 403, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Q1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Q1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q1" }, { "id": "PRU00163", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00163" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000255", "start_pos": 60, "end_pos": 246, "start_aa": "Leu", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 12 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5BIR5-1", "uniprot_ac": "Q5BIR5", "uniprot_id": "SPB8_BOVIN", "mass": { "chemical_mass": 42173.0, "monoisotopic_mass": 42173.0 }, "refseq": { "ac": "NP_001030364", "name": "serpin B8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364" }, "gene_names": [ { "name": "SERPINB8", "type": "recommended", "evidence": [ { "id": "Q5BIR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ] }, { "name": "SERPINB8", "type": "synonym", "evidence": [ { "id": "NP_001030364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364" } ] } ], "protein_names": [ { "name": "Serpin B8", "type": "recommended", "evidence": [ { "id": "Q5BIR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5/entry#names_and_taxonomy" } ] }, { "name": "serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8", "type": "synonym", "evidence": [ { "id": "NP_001030364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364" } ] }, { "name": "serpin B8", "type": "synonym", "evidence": [ { "id": "NP_001030364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364" } ] }, { "name": "serpin peptidase inhibitor, clade B (ovalbumin), member 8", "type": "synonym", "evidence": [ { "id": "NP_001030364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364" } ] } ], "function": [ { "annotation": "Has an important role in epithelial desmosome-mediated cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5#function" }, { "database": "UniProtKB", "id": "P50452", "url": "https://www.uniprot.org/uniprotkb/P50452#function" }, { "database": "UniProtKB", "id": "A0AAA9TSI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI9#function" }, { "database": "UniProtKB", "id": "ARBA00059476", "url": "https://www.uniprot.org/uniprotkb/ARBA00059476#function" }, { "database": "UniProtKB", "id": "A0AAA9SWL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWL8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINB8", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5", "locus": { "chromosome": "24", "start_pos": 12393116, "end_pos": 12424038, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001207", "url": "https://www.ensembl.org/id/ENSBTAG00000001207" } ] } } ], "crossref": [ { "id": "Q5BIR5", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001207", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001207", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19567", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19567", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513825", "url": "https://www.ncbi.nlm.nih.gov/gene/513825", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513825", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513825", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RVAHKCF", "url": "https://omabrowser.org/oma/group/RVAHKCF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIR5", "url": "https://www.orthodb.org/?gene=Q5BIR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-75205", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75205", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030364", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIR5-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDALCEANGTFAINLLKMLGEEDHLRNVFFSPLSLSSVLTMVLMGAKGNTAAQMSQALCLNESGDVHRGFQSLLREVSTSGPKCLLRTANRLFGEKTCDFLPAFKESCQKFYQADLEELSFAEDTEECRKHINDWVMEKTDGKISEILGAGTVSPLTKLVLVNAIYFKGKWNEQFDRKHTRGMPFKTNQEKKTVQMMFKQAKFKMGHVEEVPAQVLELPYVGAELSMLILLPDENTDLAVVEKALTYEKFRTWTSPEKLTEEKVQVFLPRLKLEASYDLEAFLRSLGMTDAFEEAKADFSGMSAKKNVPMSKVAHKCFVEVNEEGTEAAGATAVVRNSRCCRMEPKFCADHPFLFFIRHRETNSILFCGRFSSP", "length": 374, "header": "sp|Q5BIR5-1|SPB8_BOVIN Isoform 1 of Serpin B8 OS=Bos taurus OX=9913 GN=SERPINB8 PE=2 SV=1 CANONICAL=Q5BIR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWL8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5/entry#A0AAA9SWL8-1", "sequence": { "sequence": "MKDQRVTHLLIKMHKGVMTHISRPPPMDALCEANGTFAINLLKMLGEEDHLRNVFFSPLSLSSVLTMVLMGAKGNTAAQMSQALCLNESGDVHRGFQSLLREVSTSGPKCLLRTANRLFGEKTCDFLPAFKESCQKFYQADLEELSFAEDTEECRKHINDWVMEKTDGKISEILGAGTVSPLTKLVLVNAIYFKGKWNEQFDRKHTRGMPFKTNQEKKTVQMMFKQAKFKMGHVEEVPAQVLELPYVGAELSMLILLPDENTDLAVVEKALTYEKFRTWTSPEKLTEEKVQVFLPRLKLEASYDLEAFLRSLGMTDAFEEAKADFSGMSAKKNVPMSKVAHKCFVEVNEEGTEAAGATAVVRNSRCCRMEPKFCADHPFLFFIRHRETNSILFCGRFSSP", "length": 400, "header": "tr|A0AAA9SWL8-1|A0AAA9SWL8_BOVIN Computationally mapped isoform of Serpin B8 OS=Bos taurus OX=9913 GN=SERPINB8 PE=3 SV=1 CANONICAL=Q5BIR5-1" }, "locus": { "chromosome": "24", "start_pos": 12409252, "end_pos": 12393235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124353.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124353.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088456.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088456.1" } ] } }, { "isoform_ac": "A0AAA9T9Q8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5/entry#A0AAA9T9Q8-1", "sequence": { "sequence": "MDALCEANGTFAINLLKMLGEEDHLRNVFFSPLSLSSVLTMVLMGAKGNTAAQMSQALCLNESGDVHRGFQSLLREVSTSGPKCLLRTANRLFGEKTCDFLPAFKESCQKFYQADLEELSFAEDTEECRKHINDWVMEKTDGKISEILGAGTVSPLTKLVLVNAIYFKGKWNEQFDRKHTRGMPFKTNQEKKTVQMMFKQAKFKMGHVEEVPAQVLELPYVGAELSMLILLPDENTDLAVNEG", "length": 243, "header": "tr|A0AAA9T9Q8-1|A0AAA9T9Q8_BOVIN Computationally mapped isoform of Serpin family B member 8 OS=Bos taurus OX=9913 GN=SERPINB8 PE=3 SV=1 CANONICAL=Q5BIR5-1" }, "locus": { "chromosome": "24", "start_pos": 12406112, "end_pos": 12394901, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112413.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112413.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092647.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092647.1" } ] } }, { "isoform_ac": "A0AAA9TSI9-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5/entry#A0AAA9TSI9-1", "sequence": { "sequence": "MRAVTSVCSYYCQKTLVDWIRPPPMDALCEANGTFAINLLKMLGEEDHLRNVFFSPLSLSSVLTMVLMGAKGNTAAQMSQALCLNESGDVHRGFQSLLREVSTSGPKCLLRTANRLFGEKTCDFLPAFKESCQKFYQADLEELSFAEDTEECRKHINDWVMEKTDGKISEILGAGTVSPLTKLVLVNAIYFKGKWNEQFDRKHTRGMPFKTNQEKKTVQMMFKQAKFKMGHVEEVPAQVLELPYVGAELSMLILLPDENTDLAVVEKALTYEKFRTWTSPEKLTEEKVQVFLPRLKLEASYDLEAFLRSLGMTDAFEEAKADFSGMSAKKNVPMSKVAHKCFVEVNEEGTEAAGATAVVRNSRCCRMEPKFCADHPFLFFIRHRETNSILFCGRFSSP", "length": 398, "header": "tr|A0AAA9TSI9-1|A0AAA9TSI9_BOVIN Computationally mapped isoform of Serpin B8 OS=Bos taurus OX=9913 GN=SERPINB8 PE=3 SV=1 CANONICAL=Q5BIR5-1" }, "locus": { "chromosome": "24", "start_pos": 12420086, "end_pos": 12393235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099999.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099999.1" } ] } }, { "isoform_ac": "Q5BIR5-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5/entry#Q5BIR5-1", "sequence": { "sequence": "MDALCEANGTFAINLLKMLGEEDHLRNVFFSPLSLSSVLTMVLMGAKGNTAAQMSQALCLNESGDVHRGFQSLLREVSTSGPKCLLRTANRLFGEKTCDFLPAFKESCQKFYQADLEELSFAEDTEECRKHINDWVMEKTDGKISEILGAGTVSPLTKLVLVNAIYFKGKWNEQFDRKHTRGMPFKTNQEKKTVQMMFKQAKFKMGHVEEVPAQVLELPYVGAELSMLILLPDENTDLAVVEKALTYEKFRTWTSPEKLTEEKVQVFLPRLKLEASYDLEAFLRSLGMTDAFEEAKADFSGMSAKKNVPMSKVAHKCFVEVNEEGTEAAGATAVVRNSRCCRMEPKFCADHPFLFFIRHRETNSILFCGRFSSP", "length": 374, "header": "sp|Q5BIR5-1|SPB8_BOVIN Isoform 1 of Serpin B8 OS=Bos taurus OX=9913 GN=SERPINB8 PE=2 SV=1 CANONICAL=Q5BIR5-1" }, "locus": { "chromosome": "24", "start_pos": 12406112, "end_pos": 12393235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001597.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001597.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001597.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001597.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513825", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513825", "resource": "KEGG Pathway" }, { "id": "R-BTA-75205", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75205", "resource": "Reactome", "description": "Dissolution of Fibrin Clot" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SMX7-1", "protein_name": "Serpin B8", "gene_name": "SERPINB8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDLREANGTFAINLLKMLSEEDNLRNVFLSPLSLSSALAMVLLGAKGNTEAQMSQALCLNRVGDVHQSFQSLLKEMNKSTTQCLLRTANRLFGEKTCDFLPAFKESCQNFYEADLEELSFAEDTEECRKHINDWVKEKTEGKISEILGAGTVGPLTKLVLVNAIYFKGKWNKQFDRKYTRGMPFKTNQEKKTVQMMFKQAKFKMGYVDEVHAQVLELPYVGEELSMVILLPDDNTDLAVVEKALTYEKFRAWTNPEKLTEDKVQVFLPRLKLEESYDLEAFLRSLGMIDAFEEAKADFSGMSVRKNVPVSKVMHKCFVEVNEEGTEAAAATAVVRNSRCSRIEPRFCADHPFLFFIRHLETNSILFCGRFSSP", "length": 374 }, "evidence": [ { "id": "Q5BIR5", "url": "https://omabrowser.org/oma/group/Q5BIR5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08800-1", "protein_name": "Serpin B8", "gene_name": "Serpinb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDDLSEANGSFAISLLKILSEKDKSRNLFFCPMSVSSALAMVYLGAKGNTATQMSEVLGLSGNGDVHQSFQTLLAEINKTDTQYLLKSACRLFGEESCDFLSTFKESCHKFYQAGLEELSFAKDTEGCRKHINDWVSEKTEGKISEVLSPGTVCPLTKLVLVNAMYFKGKWKAQFDRKYTRGMPFKTNQEKKTVQMMFKHAKFKMGHVDEVNMQVLALPYAEEELSMVILLPDESTDLAVVEKALTYEKLRAWTNPETLTESQVQVFLPRLKLEESYDLETVLQNLGMTDAFEETRADFSGMTTKKNVPVSKVAHKCFVEVNEEGTEAAAATAVIRNARCCRTEPRFCADHPFLFFIWHHKTSSILFCGRFSSP", "length": 374 }, "evidence": [ { "id": "Q5BIR5", "url": "https://omabrowser.org/oma/group/Q5BIR5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P50452-1", "protein_name": "Serpin B8", "gene_name": "SERPINB8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDDLCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKDGDIHRGFQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFAEDTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTNEEKKTVQMMFKEAKFKMGYADEVHTQVLELPYVEEELSMVILLPDDNTDLAVVEKALTYEKFKAWTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRMEPRFCADHPFLFFIRHHKTNCILFCGRFSSP", "length": 374 }, "evidence": [ { "id": "Q5BIR5", "url": "https://omabrowser.org/oma/group/Q5BIR5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "epithelial cell-cell adhesion", "id": "GO:0090136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090136", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR5", "url": "https://www.uniprot.org/uniprotkb/Q5BIR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 374, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIR5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBM1-1", "uniprot_ac": "Q3ZBM1", "uniprot_id": "ARHL1_BOVIN", "mass": { "chemical_mass": 39937.0, "monoisotopic_mass": 39937.0 }, "refseq": { "ac": "XP_059748329", "name": "inactive ADP-ribosyltransferase ARH2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748329" }, "gene_names": [ { "name": "ADPRHL1", "type": "recommended", "evidence": [ { "id": "Q3ZBM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ] }, { "name": "ADPRHL1", "type": "synonym", "evidence": [ { "id": "XP_059748329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748329" } ] }, { "name": "ARH2", "type": "synonym", "evidence": [ { "id": "Q3ZBM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ] } ], "protein_names": [ { "name": "Inactive ADP-ribosyltransferase ARH2", "type": "recommended", "evidence": [ { "id": "Q3ZBM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylhydrolase-like protein 1", "type": "synonym", "evidence": [ { "id": "Q3ZBM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1/entry#names_and_taxonomy" } ] }, { "name": "[Protein ADP-ribosylarginine] hydrolase-like protein 1", "type": "synonym", "evidence": [ { "id": "Q3ZBM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1/entry#names_and_taxonomy" } ] }, { "name": "inactive ADP-ribosyltransferase ARH2", "type": "synonym", "evidence": [ { "id": "XP_059748329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748329" } ] } ], "function": [ { "annotation": "Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1#function" }, { "database": "UniProtKB", "id": "Q6AZR2", "url": "https://www.uniprot.org/uniprotkb/Q6AZR2#function" }, { "database": "UniProtKB", "id": "Q8BGK2", "url": "https://www.uniprot.org/uniprotkb/Q8BGK2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADPRHL1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1", "locus": {} } ], "crossref": [ { "id": "Q3ZBM1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020928", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020928", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519627", "url": "https://www.ncbi.nlm.nih.gov/gene/519627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519627", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LVTDFWC", "url": "https://omabrowser.org/oma/group/LVTDFWC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBM1", "url": "https://www.orthodb.org/?gene=Q3ZBM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16222:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16222:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03747", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03747", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059748329", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748329", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKFQAAMLLGAVGDALGFGHAARESSSLGARVQEEMGKGGGLDHLVLSPETWPVSDNTIMHMSTAGALITDFWCLDDLYREMVRRYVDVLEKLPEQRADPATLEGCSQLKPDNYLLAWHTPFNEKGSGFGAATKAMCVGMRYWQPERLETLVEVSVECGRMTHNHPTGFLGSLCTALFASYAVQGKRLEQWGRDMLRTVPLAEEYCKKTIRHLAEYQEHWFYFEAKWQFYLEERKIIEDTENEASFPDRYDAEEREKTYRKWSSEGRGGRRGHDAPMIAYDALLGAKGSWTELCRRAMFHGGESGATGAIAGCLFGLLHGLDAVPAGLYRELEHQDELRRLGEALHRLSSQEK", "length": 354, "header": "sp|Q3ZBM1-1|ARHL1_BOVIN Isoform 1 of Inactive ADP-ribosyltransferase ARH2 OS=Bos taurus OX=9913 GN=ADPRHL1 PE=2 SV=1 CANONICAL=Q3ZBM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ85-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1/entry#A0AAA9SZ85-1", "sequence": { "sequence": "MEKFQAAMLLGAVGDALGFGHAARESSSLGARVQEEMGKGGGLDHLVLSPETWPVSDNTIMHMSTAGALITDFWCLDDLYREMVRRYVDVLEKLPEQRADPATLEGCSQLKPDNYLLAWHTPFNEKGSGFGAATKAMCVGMRYWQPERLETLVEVSVECGRMTHNHPTGFLGSLCTALFASYAVQGKRLEQWGRDMLRTVPLAEEYCKKTIRHLAEYQEHWFYFEAKWQFYLEERKIIEDTENEASFPDRYDAEEREKTEGPALRPQPPLLPLCPPTGLQPRKHPQPTQPHLSPCPTQAAVTPDHNIPGPLPAICITEFAAFVCGTARTYRKWSSEGRGGRRGHDAPMIAYDALLGAKGSWTELCRRAMFHGGESGATGAIAGCLFGLLHGLDAVPAGLYRELEHQDELRRLGEALHRLSSQEK", "length": 424, "header": "tr|A0AAA9SZ85-1|A0AAA9SZ85_BOVIN Computationally mapped isoform of ADP-ribosylhydrolase like 1 OS=Bos taurus OX=9913 GN=ADPRHL1 PE=3 SV=1 CANONICAL=Q3ZBM1-1" }, "locus": { "chromosome": "12", "start_pos": 86661001, "end_pos": 86648179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132765.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132765.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090734.1" } ] } }, { "isoform_ac": "Q3ZBM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1/entry#Q3ZBM1-1", "sequence": { "sequence": "MEKFQAAMLLGAVGDALGFGHAARESSSLGARVQEEMGKGGGLDHLVLSPETWPVSDNTIMHMSTAGALITDFWCLDDLYREMVRRYVDVLEKLPEQRADPATLEGCSQLKPDNYLLAWHTPFNEKGSGFGAATKAMCVGMRYWQPERLETLVEVSVECGRMTHNHPTGFLGSLCTALFASYAVQGKRLEQWGRDMLRTVPLAEEYCKKTIRHLAEYQEHWFYFEAKWQFYLEERKIIEDTENEASFPDRYDAEEREKTYRKWSSEGRGGRRGHDAPMIAYDALLGAKGSWTELCRRAMFHGGESGATGAIAGCLFGLLHGLDAVPAGLYRELEHQDELRRLGEALHRLSSQEK", "length": 354, "header": "sp|Q3ZBM1-1|ARHL1_BOVIN Isoform 1 of Inactive ADP-ribosyltransferase ARH2 OS=Bos taurus OX=9913 GN=ADPRHL1 PE=2 SV=1 CANONICAL=Q3ZBM1-1" }, "locus": { "chromosome": "12", "start_pos": 86661001, "end_pos": 86648179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035299.4", "url": "https://www.ensembl.org/id/ENSBTAT00000035299.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035177.2", "url": "https://www.ensembl.org/id/ENSBTAP00000035177.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "site_lbl": "Ser27" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519627", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519627", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7IPD8-1", "protein_name": "Inactive ADP-ribosyltransferase ARH2", "gene_name": "Adprhl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKFKAAMLLGSVGDALGYGNVCRENSALGSIQEELQKTGGLDSLVLSPGKWPVSDNTIMHMATAEALTTDYWCLDDLYREMVKRYVETVEKLVEHRPDPSTIEGCLQLKPDNYLLAWHTPFSEKGSGFGAATKAMCIGMRYWKPERLETLVEVSIECGRMTHNHPTGFLGSLCTALFASYAVQGKPLVQWGRDMLKVVPLAEEYCRKTIRHMAEYQEHWFYFEAKWQFYLEERKISEDTESKATFPGNYDAEERDKTYKKWSSEGRGGRRGHDAPMIAYDALLAAGNNWTELCQRAMFHGGESGATGTIAGCLFGLLHGLATVPRGLYQELEHKGRLEDLGTALHRLSTEEK", "length": 353 }, "evidence": [ { "id": "Q3ZBM1", "url": "https://omabrowser.org/oma/group/Q3ZBM1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8W4FD57-1", "protein_name": "Inactive ADP-ribosyltransferase ARH2", "gene_name": "ADPRHL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKFRAAMLLGAVGDALGYRNAFMENSASGPRVQEELQKVGGLDHLVLAPEKWPVSDNTIMHMATAEALVTDFWCLDDLYREMVRRYVDALEKLPEHRADPATIEGCSQLKPDNYLLAWHTPFNDKGSGFGAATKAMCVGMRYWKPERLGTLVEVSVECGRMTHNHPTGFLGSLCTALFASYAIQGKRLEQWGRDMLRAVPLAEDYCKKTIRHLAEYQEHWFYFEAKWQFYLEERKISEDSESGATFPDHYDAEERDKTYRKWSSEGRGGRRGHDAPMIAYDALLGAKGSWAELCQRAMFHGGESGASGAIAGCLFGLLHGLDAVPAGLYRELEHKEQLGRLGETLHRLSSEEK", "length": 354 }, "evidence": [ { "id": "Q3ZBM1", "url": "https://omabrowser.org/oma/group/Q3ZBM1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5XJB9-1", "protein_name": "Inactive ADP-ribosyltransferase arh2", "gene_name": "adprhl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEKFQAAMVLGAVGDALGSRWQTCSSGSQIQQELRALGGLAALKLDAEHWPLSDGALMHMTTAEALITDYWCLEDLYRELVRLYVEAMVSLQGRVPEPSTVEGCANLKPHNFLLAWHTPFNEKGSGHGAATKAMCIGMRYWQPERLHTLVEVSIEAGRMTHNHPIGFLGSLCTALFASFAVQGRPLVSWGRELLKTLPKAEEYCRKTIRHMAEYQETWFYFEAKWQFYLEERGIEDGQSKPSFPERYDADETDRMYKRWSSEGCAGRRGHDAPMIAYDALLAAGSDWEELCRRAILHGGESSATGLISGCLFGLLHGLSAAPTGLHQDLDRREKLQDLGERLYRAAALEK", "length": 350 }, "evidence": [ { "id": "Q3ZBM1", "url": "https://omabrowser.org/oma/group/Q3ZBM1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" }, { "name": "ADP-ribosylarginine hydrolase activity", "id": "GO:0003875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003875", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" }, { "name": "hydrolase activity, hydrolyzing N-glycosyl compounds", "id": "GO:0016799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016799", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "sarcomere", "id": "GO:0030017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cardiac myofibril assembly", "id": "GO:0055003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055003", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" }, { "name": "protein de-ADP-ribosylation", "id": "GO:0051725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051725", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" }, { "name": "cardiac chamber ballooning", "id": "GO:0003242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003242", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBM1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85#function" }, { "id": "A0AAA9SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85" }, { "id": "PIRSR605502-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605502-1" } ], "binding_site_uniprot": 56, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 56, "end_pos": 56, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85#function" }, { "id": "A0AAA9SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ85" }, { "id": "PIRSR605502-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605502-1" } ], "binding_site_uniprot": 57, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 57, "end_pos": 57, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 27 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBN6-1", "uniprot_ac": "Q3ZBN6", "uniprot_id": "GA45A_BOVIN", "mass": { "chemical_mass": 18337.0, "monoisotopic_mass": 18337.0 }, "refseq": { "ac": "NP_001029419", "name": "growth arrest and DNA damage-inducible protein GADD45 alpha", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029419" }, "gene_names": [ { "name": "GADD45A", "type": "recommended", "evidence": [ { "id": "Q3ZBN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ] }, { "name": "GADD45A", "type": "synonym", "evidence": [ { "id": "NP_001029419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029419" } ] } ], "protein_names": [ { "name": "Growth arrest and DNA damage-inducible protein GADD45 alpha", "type": "recommended", "evidence": [ { "id": "Q3ZBN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6/entry#names_and_taxonomy" } ] }, { "name": "growth arrest and DNA damage-inducible protein GADD45 alpha", "type": "synonym", "evidence": [ { "id": "NP_001029419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029419" } ] } ], "function": [ { "annotation": "Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GADD45A", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6", "locus": { "chromosome": "3", "start_pos": 77648760, "end_pos": 77651872, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013860", "url": "https://www.ensembl.org/id/ENSBTAG00000013860" } ] } } ], "crossref": [ { "id": "Q3ZBN6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013860", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505463", "url": "https://www.ncbi.nlm.nih.gov/gene/505463", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505463", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505463", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FRMTFEE", "url": "https://omabrowser.org/oma/group/FRMTFEE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBN6", "url": "https://www.orthodb.org/?gene=Q3ZBN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6804114", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804114", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029419", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T0S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDIDILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER", "length": 165, "header": "sp|Q3ZBN6-1|GA45A_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Bos taurus OX=9913 GN=GADD45A PE=2 SV=1 CANONICAL=Q3ZBN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0S2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6/entry#A0AAA9T0S2-1", "sequence": { "sequence": "MTLEEFSAGEQKTESDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDIDILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER", "length": 131, "header": "tr|A0AAA9T0S2-1|A0AAA9T0S2_BOVIN Computationally mapped isoform of Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Bos taurus OX=9913 GN=GADD45A PE=3 SV=1 CANONICAL=Q3ZBN6-1" }, "locus": { "chromosome": "3", "start_pos": 77651643, "end_pos": 77649323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096638.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096638.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089978.1" } ] } }, { "isoform_ac": "A0AAA9TBY2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6/entry#A0AAA9TBY2-1", "sequence": { "sequence": "MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVIRIHHSGRILP", "length": 60, "header": "tr|A0AAA9TBY2-1|A0AAA9TBY2_BOVIN Computationally mapped isoform of Growth arrest and DNA damage inducible alpha OS=Bos taurus OX=9913 GN=GADD45A PE=4 SV=1 CANONICAL=Q3ZBN6-1" }, "locus": { "chromosome": "3", "start_pos": 77651643, "end_pos": 77649400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119745.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119745.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095550.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095550.1" } ] } }, { "isoform_ac": "Q3ZBN6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6/entry#Q3ZBN6-1", "sequence": { "sequence": "MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDIDILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER", "length": 165, "header": "sp|Q3ZBN6-1|GA45A_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Bos taurus OX=9913 GN=GADD45A PE=2 SV=1 CANONICAL=Q3ZBN6-1" }, "locus": { "chromosome": "3", "start_pos": 77651643, "end_pos": 77649323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033450.2", "url": "https://www.ensembl.org/id/ENSBTAT00000033450.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000033363.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "site_lbl": "Thr2" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505463", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505463", "resource": "KEGG Pathway" }, { "id": "R-BTA-6804114", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804114", "resource": "Reactome", "description": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" } ], "orthologs": [ { "uniprot_canonical_ac": "P24522-1", "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 alpha", "gene_name": "GADD45A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER", "length": 165 }, "evidence": [ { "id": "Q3ZBN6", "url": "https://omabrowser.org/oma/group/Q3ZBN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P48316-1", "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 alpha", "gene_name": "Gadd45a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLEEFSAAEQKTERMDTVGDALEEVLSKARSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIRAFCCENDINILRVSNPGRLAELLLLENDAGPAESGGAAQTPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER", "length": 165 }, "evidence": [ { "id": "Q3ZBN6", "url": "https://omabrowser.org/oma/group/Q3ZBN6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "signal transduction in response to DNA damage", "id": "GO:0042770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042770", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "negative regulation of blood vessel endothelial cell migration", "id": "GO:0043537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043537", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "positive regulation of reactive oxygen species metabolic process", "id": "GO:2000379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000379", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBN6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBN6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBN6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZR5-1", "uniprot_ac": "Q3SZR5", "uniprot_id": "CMI2C_BOVIN", "mass": { "chemical_mass": 23379.0, "monoisotopic_mass": 23379.0 }, "refseq": { "ac": "NP_001070462", "name": "ciliary microtubule inner protein 2C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" }, "gene_names": [ { "name": "CIMIP2C", "type": "recommended", "evidence": [ { "id": "Q3SZR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ] }, { "name": "FAM166C", "type": "recommended", "evidence": [ { "id": "Q3SZR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ] }, { "name": "C11H2orf70", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] }, { "name": "CIMIP2C", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] }, { "name": "FAM166C", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" }, { "id": "Q3SZR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ] } ], "protein_names": [ { "name": "Ciliary microtubule inner protein 2C", "type": "recommended", "evidence": [ { "id": "Q3SZR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5/entry#names_and_taxonomy" } ] }, { "name": "UPF0573 protein C2orf70 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] }, { "name": "chromosome 11 C2orf70 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] }, { "name": "ciliary microtubule inner protein 2C", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] }, { "name": "protein FAM166C", "type": "synonym", "evidence": [ { "id": "NP_001070462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Binds to the intra-tubulin interfaces (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5#function" }, { "database": "UniProtKB", "id": "Q9DAS2", "url": "https://www.uniprot.org/uniprotkb/Q9DAS2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIMIP2C", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5", "locus": { "chromosome": "11", "start_pos": 72984743, "end_pos": 73002321, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031150", "url": "https://www.ensembl.org/id/ENSBTAG00000031150" } ] } } ], "crossref": [ { "id": "Q3SZR5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767918", "url": "https://www.ncbi.nlm.nih.gov/gene/767918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR018902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767918", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767918", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQKRDCY", "url": "https://omabrowser.org/oma/group/RQKRDCY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZR5", "url": "https://www.orthodb.org/?gene=Q3SZR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34924", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34924", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34924:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34924:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF10629", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10629", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070462", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRSAGTLLTEFNAAYVPPGLMPGYKGHVPGVAFSFGSPYGTTTLKYFQDQRNAALGRSSTAFSRGGHFPTIFSLNPTQVLRNRALTRDRWLHTPSYTRFNLDSSRWAELLHFYQMAQRHREHYQDKTGLVHRVPYFVLPVKEWDRYPIPTDLPPLSPKEKWHLLRVAPENLRTYQTFPSGKRVSPQERQRRDCYFEFRA", "length": 201, "header": "sp|Q3SZR5-1|CMI2C_BOVIN Isoform 1 of Ciliary microtubule inner protein 2C OS=Bos taurus OX=9913 GN=CIMIP2C PE=1 SV=1 CANONICAL=Q3SZR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0X3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5/entry#A0AAA9T0X3-1", "sequence": { "sequence": "ADNSWTGYKGHVPGVAFSFGSPYGTTTLKYFQDQRNAALGRSSTAFSRGGHFPTIFSLNPTQVLRNRALTRDRWLHTPSYTRFNLDSSRWAELLHFYQMAQRHREHYQDKTGLVHRVPYFVLPVKEWDRYPIPTDLPPLSPKEKWHLLRVAPENLRTYQTFPSGKRVSPQERQRRDCYFEFRA", "length": 183, "header": "tr|A0AAA9T0X3-1|A0AAA9T0X3_BOVIN Computationally mapped isoform of Ciliary microtubule inner protein 2C OS=Bos taurus OX=9913 GN=FAM166C PE=3 SV=1 CANONICAL=Q3SZR5-1" }, "locus": { "chromosome": "11", "start_pos": 72990904, "end_pos": 72984804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089299.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089299.1" } ] } }, { "isoform_ac": "Q3SZR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5/entry#Q3SZR5-1", "sequence": { "sequence": "MASRSAGTLLTEFNAAYVPPGLMPGYKGHVPGVAFSFGSPYGTTTLKYFQDQRNAALGRSSTAFSRGGHFPTIFSLNPTQVLRNRALTRDRWLHTPSYTRFNLDSSRWAELLHFYQMAQRHREHYQDKTGLVHRVPYFVLPVKEWDRYPIPTDLPPLSPKEKWHLLRVAPENLRTYQTFPSGKRVSPQERQRRDCYFEFRA", "length": 201, "header": "sp|Q3SZR5-1|CMI2C_BOVIN Isoform 1 of Ciliary microtubule inner protein 2C OS=Bos taurus OX=9913 GN=CIMIP2C PE=1 SV=1 CANONICAL=Q3SZR5-1" }, "locus": { "chromosome": "11", "start_pos": 73002282, "end_pos": 72984804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044082.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044082.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000041595.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:767918", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767918", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NJV1-1", "protein_name": "Ciliary microtubule inner protein 2C", "gene_name": "CIMIP2C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRSAGTLLTEFNAAYVPPGLMPGYQGHVPTVAFSFGAPYGTTTLKYFQDHRNRAMEKSHTPFSQGGHFPTIFSTNPNLLLMERASTRDRWLHKPSYTRFNLDSHRSTELTNFYQMVQQHRKYYQDKTGTVPRVPYFAMPVREPERYPLPTVLPPLCPKKKWHLLRLAPENLKTYQTFPSGKRVSPQERKKRDCYFEFRA", "length": 201 }, "evidence": [ { "id": "Q3SZR5", "url": "https://omabrowser.org/oma/group/Q3SZR5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZW52-1", "protein_name": "Ciliary microtubule inner protein 2C", "gene_name": "Cimip2c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRRLLWAVRQRRSREHTAKRTHCPRTNSGCQACGCRVTGRLFTAGLSRATAPGLAASTMAFRSAGTLMTEFNATFVPPALMPGYKGHVPGVASSFGSSYGNTTFKYFQDLRRTGLEKSYALLSGGRFPTIFSPNSPLVLTDQSQNWDLWLHQPTYSRFNLDNGRITELNHFYKTVQHQRKYYQDKTGTVPRVPYFVLPVKEPDRYPLPTDLPPLSEKSKWNLLRVSPDYVRTYQTFPSGKRVSAQERQRRDLYFEFRA", "length": 259 }, "evidence": [ { "id": "Q3SZR5", "url": "https://omabrowser.org/oma/group/Q3SZR5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SDN7-1", "protein_name": "Ciliary microtubule inner protein 2C", "gene_name": "CIMIP2C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASRSAGTLLTEFKAAYVPPGLMPGYQGHVPGAAFSFGSTYGATTLKYFQDQRNAALEQSHHPFSKGGHFPTIFSPDPNLVLRNRSQTWDRWLHAPRYTRFNLDGGRSAELSRFYQMAQQHREYYRDKTGTVPRVPYFVLPVREWERYPIPTDLPPLSPKKKWHLLRVAPENLRTYQTFPSGKRVPPQERQRRDHYFEFRA", "length": 201 }, "evidence": [ { "id": "Q3SZR5", "url": "https://omabrowser.org/oma/group/Q3SZR5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9DAS2-1", "protein_name": "Ciliary microtubule inner protein 2C", "gene_name": "Cimip2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFRSAGTLMTEFNAAFVPPALMPGYKGHVPGVASSFGSSYGNTTFKYFQDLRNTGLEKSYALLSGGCFPTIFSPNSPLVLTDNSQNWDRWLHQPTYSRSNQDNGRTTELTNFYKTVQQQRKYYQDKTGILSRVPYFVLPVKEPDRYPLPTDLPPLSEKSKWNLLRLSPDYKRTYQTFPSGKRVSSQERQRRDLYFEFRA", "length": 200 }, "evidence": [ { "id": "Q3SZR5", "url": "https://omabrowser.org/oma/group/Q3SZR5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" }, { "name": "axonemal microtubule", "id": "GO:0005879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR5", "url": "https://www.uniprot.org/uniprotkb/Q3SZR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 201, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZR5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3B7M1-1", "uniprot_ac": "Q3B7M1", "uniprot_id": "KLH36_BOVIN", "mass": { "chemical_mass": 69717.0, "monoisotopic_mass": 69717.0 }, "refseq": { "ac": "NP_001070586", "name": "kelch-like protein 36", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" }, "gene_names": [ { "name": "KLHL36", "type": "recommended", "evidence": [ { "id": "Q3B7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ] }, { "name": "C16orf44", "type": "synonym", "evidence": [ { "id": "NP_001070586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" } ] }, { "name": "C18H16orf44", "type": "synonym", "evidence": [ { "id": "NP_001070586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" } ] }, { "name": "KLHL36", "type": "synonym", "evidence": [ { "id": "NP_001070586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" } ] } ], "protein_names": [ { "name": "Kelch-like protein 36", "type": "recommended", "evidence": [ { "id": "Q3B7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 36", "type": "synonym", "evidence": [ { "id": "NP_001070586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" } ] }, { "name": "kelch-like protein 36", "type": "synonym", "evidence": [ { "id": "NP_001070586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586" } ] } ], "function": [ { "annotation": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1#function" }, { "database": "UniProtKB", "id": "A0AAA9T2F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F3#function" }, { "database": "UniProtKB", "id": "ARBA00003098", "url": "https://www.uniprot.org/uniprotkb/ARBA00003098#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL36", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1", "locus": { "chromosome": "18", "start_pos": 10848964, "end_pos": 10837381, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008385", "url": "https://www.ensembl.org/id/ENSBTAG00000008385" } ] } } ], "crossref": [ { "id": "Q3B7M1", "url": "https://alphafold.ebi.ac.uk/entry/Q3B7M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008385", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008385", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18266", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18266", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18475", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18475", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768061", "url": "https://www.ncbi.nlm.nih.gov/gene/768061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768061", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RPAEDRW", "url": "https://omabrowser.org/oma/group/RPAEDRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3B7M1", "url": "https://www.orthodb.org/?gene=Q3B7M1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070586", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7M1-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEGSRQTRVSRPYKISESSKVYRWAEHSGTVLQRLNEQRLRGLFCDVVLVADEQRLPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTAVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFILSRFGTLSFTPAFLQNISMQKLCAYLGSSEVQRECEHDLLQAALQWLTQQPEREAHAYQVLENIHFPLIPKNDLLHRVKPAVCSLLPREANCEGFIEEAVRYHNSLAAQPVMQTKRTALRTTQECLLFVGGEVSERCLELSDDTCYLDAQSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMSTARGWHSMCSLGDSIYSIGGSDDSLESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDRDKDKWSEGTELPKAIAGVSACVCALKPRLEDKKKKGKGKRPQDHGQ", "length": 616, "header": "sp|Q3B7M1-1|KLH36_BOVIN Isoform 1 of Kelch-like protein 36 OS=Bos taurus OX=9913 GN=KLHL36 PE=2 SV=1 CANONICAL=Q3B7M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2F3-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1/entry#A0AAA9T2F3-1", "sequence": { "sequence": "MMEGSRQTRVSRPYKISESSKVYRWAEHSGTVLQRLNEQRLRGLFCDVVLVADEQRLPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTAVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFILSRFGTLSFTPAFLQNISMQKLCAYLGSSEVQRECEHDLLQAALQWLTQQPEREAHAYQVLENIHFPLIPKNDLLHRVKPAVCSLLPREANCEGFIEEAVRYHNSLAAQPVMQTKRTALRTTQECLLFVGGEVSERCLELSDDTCYLDAQSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMSTARGWHSMCSLGDSIYSIGGSDDSLESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDRDKDKWSEGTELPKAIAGVSACVCALKPRLEDKKKKGKGKRPQDHGQ", "length": 553, "header": "tr|A0AAA9T2F3-1|A0AAA9T2F3_BOVIN Computationally mapped isoform of Kelch-like protein 36 OS=Bos taurus OX=9913 GN=KLHL36 PE=4 SV=1 CANONICAL=Q3B7M1-1" }, "locus": { "chromosome": "18", "start_pos": 10848806, "end_pos": 10839967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107420.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107420.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090813.1" } ] } }, { "isoform_ac": "Q3B7M1-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1/entry#Q3B7M1-1", "sequence": { "sequence": "MMEGSRQTRVSRPYKISESSKVYRWAEHSGTVLQRLNEQRLRGLFCDVVLVADEQRLPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTAVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFILSRFGTLSFTPAFLQNISMQKLCAYLGSSEVQRECEHDLLQAALQWLTQQPEREAHAYQVLENIHFPLIPKNDLLHRVKPAVCSLLPREANCEGFIEEAVRYHNSLAAQPVMQTKRTALRTTQECLLFVGGEVSERCLELSDDTCYLDAQSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMSTARGWHSMCSLGDSIYSIGGSDDSLESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDRDKDKWSEGTELPKAIAGVSACVCALKPRLEDKKKKGKGKRPQDHGQ", "length": 616, "header": "sp|Q3B7M1-1|KLH36_BOVIN Isoform 1 of Kelch-like protein 36 OS=Bos taurus OX=9913 GN=KLHL36 PE=2 SV=1 CANONICAL=Q3B7M1-1" }, "locus": { "chromosome": "18", "start_pos": 10848806, "end_pos": 10839967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011036.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011036.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011036.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011036.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768061", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768061", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T616-1", "protein_name": "Kelch-like protein 36", "gene_name": "KLHL36", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "IMEGSRQTRVSRPYKISESSKVYRWADHSTTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELVGASYIGLKAVVDFLYGGELVLDGGNIDYILETAHLLQIWTAVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILSRFGTLSFTPDFLQSISMQKLCLYLGSSDVQRECEHDLLQAALQWLTQQPEREAHAFEVLENIHFPLIPKNDLLHRVKPAVCALLPREANCEGFIEEAVRYHNSLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAQNEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMPTARGWHSMCSLGDSIYSIGGSDDSIESMERFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWENTAFSKTVQVYDREKDKWSKGTDLPKAIAGVSACVCALTPRLEDKKKKGKGKRPQDRGQ", "length": 616 }, "evidence": [ { "id": "Q3B7M1", "url": "https://omabrowser.org/oma/group/Q3B7M1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GRX3-1", "protein_name": "Kelch-like protein 36", "gene_name": "Klhl36", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEASKQIRVSRPYKISESSKVYHWADHSTTVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELVGTSYVGLKAVVDFLYSSELELDGNNIDYILETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDRFVLNHFSTLSFTPDFLQTVSVQKLCVYLSSGQIQHKWEYDLLQAALQWLTQQPEREVHICRVLENIRFPLFPEDILLQRVKLAMCSLLPSEANCEGFLEEALHYHNSLVAQPVLQTKRTVLRSEECLLFVGGEVSERCLELSDDTCYLDTKSEQWVKETSLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRRKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEEKRPMTTARGWHSMCSLGDSIYSIGGSDDHMESMERFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWESTAFSRAVQVYDHEADRWSRGPDLPNAIAGVSACVCALNPRLEEKKKRSKDKRQDRGQ", "length": 613 }, "evidence": [ { "id": "Q3B7M1", "url": "https://omabrowser.org/oma/group/Q3B7M1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q66HD2-1", "protein_name": "Kelch-like protein 36", "gene_name": "Klhl36", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEASKQMRVSRPYKISESSKVYHWPGHSTTVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELVGTSYVGLKAVVDFLYSSELELDGSNIDYILETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFVLNHFSTLSFTPDFLQTVSVQKLCIYLSSGQVQHTWEYDLLQAALQWLTQQPEREVHTCRVLENIRFPLFPEDILLQRVKLAMCSLLPSEANGEGFVEEAMHYHNSLVAQPVLQTKRTLLRSEECLLFVGGEVSERCLELSDDTCYLDTKNEQWVKETSLPARRSHHCVAVLGGFIFVAGGSFSRDNGGNAASNLLYRYDPRRKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDHMESMERFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWESTAFSRAVQVYDREANRWSRGPDLPNAIAGVSACVCALNPRLEEKKKKNKDKRQDRGQ", "length": 613 }, "evidence": [ { "id": "Q3B7M1", "url": "https://omabrowser.org/oma/group/Q3B7M1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N4N3-1", "protein_name": "Kelch-like protein 36", "gene_name": "KLHL36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPEDKKKKGKGKRHQDRGQ", "length": 616 }, "evidence": [ { "id": "Q3B7M1", "url": "https://omabrowser.org/oma/group/Q3B7M1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R124-1", "protein_name": "Kelch-like protein 36", "gene_name": "Klhl36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASKQMRVSRPYKISESSKVYHWPDHSTAVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLLAVCSDYFNSMFTLGMREAFQKEVELVGTSYVGLKAVVDFLYSSELELDGSNIDYILETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFVLSHFSTLSFTPDFLQSISVQKLCVYLSSGQVQHKWEYDLLQVALQWLTQQPEREVHTRRVLENIRFPLFPEDILLQRVKLAMCSLLPSEANGEGFVEEAMHYHNSLVAQPVLQTKRTLLRSEECLLFVGGEVSERCLELSDDTCYLDTKNEQWVKETSLPARRSHHCVAVLGGFIFIAGGSFSRDNGGNAASNLLYRYDPRRKQWIKVASMNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDHMESMERFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWESTAFSRAVQVYDSEANRWSRGPDLPNAIAGVSACVCALNPRLEEKKKRNKDKCQDRGQ", "length": 613 }, "evidence": [ { "id": "Q3B7M1", "url": "https://omabrowser.org/oma/group/Q3B7M1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3B7M1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 616, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3B7M1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3B7M1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3B7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M1" }, { "id": "PRU00037", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000255", "start_pos": 46, "end_pos": 113, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDH9-1", "uniprot_ac": "Q2YDH9", "uniprot_id": "CC172_BOVIN", "mass": { "chemical_mass": 31183.0, "monoisotopic_mass": 31183.0 }, "refseq": { "ac": "NP_001069301", "name": "coiled-coil domain-containing protein 172", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301" }, "gene_names": [ { "name": "CCDC172", "type": "recommended", "evidence": [ { "id": "Q2YDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9" } ] }, { "name": "C26H10orf96", "type": "synonym", "evidence": [ { "id": "NP_001069301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301" } ] }, { "name": "CCDC172", "type": "synonym", "evidence": [ { "id": "NP_001069301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 172", "type": "recommended", "evidence": [ { "id": "Q2YDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9/entry#names_and_taxonomy" } ] }, { "name": "UPF0628 protein C10orf96 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301" } ] }, { "name": "coiled-coil domain-containing protein 172", "type": "synonym", "evidence": [ { "id": "NP_001069301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDH9", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC172", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9", "locus": { "chromosome": "26", "start_pos": 36807371, "end_pos": 36749674, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032299", "url": "https://www.ensembl.org/id/ENSBTAG00000032299" } ] } } ], "crossref": [ { "id": "Q2YDH9", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032299", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032299", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522573", "url": "https://www.ncbi.nlm.nih.gov/gene/522573", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522573", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522573", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQCNEIT", "url": "https://omabrowser.org/oma/group/RQCNEIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDH9", "url": "https://www.orthodb.org/?gene=Q2YDH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22419:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22419:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28385", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28385", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069301", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3S9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDH9", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDH9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLESLFQHIIFSEHQAEESRRLMREVRSEINRCREKIKKAAEQLNKEKIQLESKVQQFSEKAFLLQLLKTHENALERQCNEITNQRNMLLQTFEATKRRVTEEEEKFIKEITDFNNEYELTKKRERLMKENVKIQISDLENQANILKMEMKSMEHDSDLLNELQRQKNELIQELSTLQRKLKGFEDKKHEAICTTKYLEAEKIKINEKPQNDAECLRLKKELELYKEDDMQSVHDALQTEIEFLELTLAQKDHQETNNL", "length": 260, "header": "sp|Q2YDH9-1|CC172_BOVIN Isoform 1 of Coiled-coil domain-containing protein 172 OS=Bos taurus OX=9913 GN=CCDC172 PE=2 SV=1 CANONICAL=Q2YDH9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3S9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9/entry#A0AAA9T3S9-1", "sequence": { "sequence": "MSLESLFQHIIFSEHQAEESRRLMREVRSEINRCREKIKKAAEQLNKEKIQLESKVQQFSEKAFLLQLLKTHENALERQCNEITNQRNMLLQTFEATKRRVTEEEEKFIKEITDFNNEYELTKKRERLMKENVKIQISDLENQANILKMEMKSMEHDSDLLNELQRQKNELIQELSTLQRKLKGFEDKKHEAICTTKYLEAEKIKINEKPQNDAECLRFHVRNRSLITESMKRQMKPSFT", "length": 240, "header": "tr|A0AAA9T3S9-1|A0AAA9T3S9_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 172 OS=Bos taurus OX=9913 GN=CCDC172 PE=3 SV=1 CANONICAL=Q2YDH9-1" }, "locus": { "chromosome": "26", "start_pos": 36787780, "end_pos": 36750224, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091020.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091020.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091302.1" } ] } }, { "isoform_ac": "Q2YDH9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9/entry#Q2YDH9-1", "sequence": { "sequence": "MSLESLFQHIIFSEHQAEESRRLMREVRSEINRCREKIKKAAEQLNKEKIQLESKVQQFSEKAFLLQLLKTHENALERQCNEITNQRNMLLQTFEATKRRVTEEEEKFIKEITDFNNEYELTKKRERLMKENVKIQISDLENQANILKMEMKSMEHDSDLLNELQRQKNELIQELSTLQRKLKGFEDKKHEAICTTKYLEAEKIKINEKPQNDAECLRLKKELELYKEDDMQSVHDALQTEIEFLELTLAQKDHQETNNL", "length": 260, "header": "sp|Q2YDH9-1|CC172_BOVIN Isoform 1 of Coiled-coil domain-containing protein 172 OS=Bos taurus OX=9913 GN=CCDC172 PE=2 SV=1 CANONICAL=Q2YDH9-1" }, "locus": { "chromosome": "26", "start_pos": 36807172, "end_pos": 36750224, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045806.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045806.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043167.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043167.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522573", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522573", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P0C7W6-1", "protein_name": "Coiled-coil domain-containing protein 172", "gene_name": "CCDC172", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK", "length": 258 }, "evidence": [ { "id": "Q2YDH9", "url": "https://omabrowser.org/oma/group/Q2YDH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AXT4-1", "protein_name": "Coiled-coil domain-containing protein 172", "gene_name": "Ccdc172", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLESLFQHIIFTEHQAEESRRVMREVRSEIARCRGKIKKATEDLNEEKIKLESKVQQFSEKTFLLELLKTRENALERQCSAIVSERDRLLQACEAIKKKTTEQEERFIKEITDFNDNYEITKKRDALMEEDIKLEMADLENQAEALRGEMKSMEYNSGQLQELQKLKSELLQELFTLQKKLKVLKDEETEAICITKHLEAEKIKIREKPQHDPECVRRLKRELDLYKEEDMESVCRALQIEVDLLESTLVPKDPQDNNSLSR", "length": 263 }, "evidence": [ { "id": "Q2YDH9", "url": "https://omabrowser.org/oma/group/Q2YDH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q810N9-1", "protein_name": "Coiled-coil domain-containing protein 172", "gene_name": "Ccdc172", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLESLFQHIIFSEHQAEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQACEAIKNKTTEEEERFIKEITDFNDNYEITKKRDTLMKENIEMEMADLDSQADVLRREMKSVERNRGQLWELQKLKNELLQELFTLQKKLKVLKDEETEAICITKQLEAEKTKVRDKPQHDPECVRLKRELDLYKAEDMESVYRALQAEVDLLELALAPKDPQDSNSLSHEPPHT", "length": 267 }, "evidence": [ { "id": "Q2YDH9", "url": "https://omabrowser.org/oma/group/Q2YDH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH9", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH9", "url": "https://www.uniprot.org/uniprotkb/Q2YDH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 260, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ38-1", "uniprot_ac": "Q2KJ38", "uniprot_id": "F110B_BOVIN", "mass": { "chemical_mass": 40530.0, "monoisotopic_mass": 40530.0 }, "refseq": { "ac": "NP_001070486", "name": "protein FAM110B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070486" }, "gene_names": [ { "name": "FAM110B", "type": "recommended", "evidence": [ { "id": "Q2KJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ] }, { "name": "FAM110B", "type": "synonym", "evidence": [ { "id": "NP_001070486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070486" } ] } ], "protein_names": [ { "name": "Protein FAM110B", "type": "recommended", "evidence": [ { "id": "Q2KJ38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38/entry#names_and_taxonomy" } ] }, { "name": "protein FAM110B", "type": "synonym", "evidence": [ { "id": "NP_001070486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070486" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM110B", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38", "locus": { "chromosome": "14", "start_pos": 24435416, "end_pos": 24291547, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050550", "url": "https://www.ensembl.org/id/ENSBTAG00000050550" } ] } } ], "crossref": [ { "id": "Q2KJ38", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050550", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050550", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767946", "url": "https://www.ncbi.nlm.nih.gov/gene/767946", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767946", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767946", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IASMKSP", "url": "https://omabrowser.org/oma/group/IASMKSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ38", "url": "https://www.orthodb.org/?gene=Q2KJ38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ALD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ALD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ38-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTESLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKGFGGGGGGAKSEGGAPRETLKLEILKNILNSSEGSSTGSGHKHSARNWPAPRADAAELHRHSFAESLRARPAPGRGSPQEGGSHVGRRPPEPTSSAAAAADAFLHVSHSSSDIRQGPGARPLKAILPCSSSAPPLPPKPKVAAPAAVKSPEAEAAEPAGGVGRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 380, "header": "sp|Q2KJ38-1|F110B_BOVIN Isoform 1 of Protein FAM110B OS=Bos taurus OX=9913 GN=FAM110B PE=2 SV=1 CANONICAL=Q2KJ38-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5D2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38/entry#A0AAA9T5D2-1", "sequence": { "sequence": "MPGPGVIGRRVSLMGRRQEELARGNPPPLFFRSRAGLRAPGAGGGAPCSRRDHLPPGLLCLQLNTKTWRRLPHPSGRRKERRGPIKGTWRLVASPHRPAGEGARGLESRGSDRAGDEALPPPLTLGSGPSAALCAARTCVCPAHPEARTRASTTAAGERVPAMPTESLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKGFGGGGGGAKSEGGAPRETLKLEILKNILNSSEGSSTGSGHKHSARNWPAPRADAAELHRHSFAESLRARPAPGRGSPQEGGSHVGRRPPEPTSSAAAAADAFLHVSHSSSDIRQGPGARPLKAILPCSSSAPPLPPKPKVAAPAAVKSPEAEAAEPAGGVGRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 542, "header": "tr|A0AAA9T5D2-1|A0AAA9T5D2_BOVIN Computationally mapped isoform of Protein FAM110B OS=Bos taurus OX=9913 GN=FAM110B PE=3 SV=1 CANONICAL=Q2KJ38-1" }, "locus": { "chromosome": "14", "start_pos": 24432259, "end_pos": 24430520, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095541.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095541.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091762.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091762.1" } ] } }, { "isoform_ac": "A0AAF7ALD7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38/entry#A0AAF7ALD7-1", "sequence": { "sequence": "MAAVSNWISRAPLLFFLTLELEANKTLQPGKEVKAISCSGEYLKGARIPCDSCLQLGKHLFPSQLCLQLNTKTWRRLPHPSGRRKERRGPIKGTWRLVASPHRPAGEGARGLESRGSDRAGDEALPPPLTLGSGPSAALCAARTCVCPAHPEARTRASTTAAGERVPAMPTESLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKGFGGGGGGAKSEGGAPRETLKLEILKNILNSSEGSSTGSGHKHSARNWPAPRADAAELHRHSFAESLRARPAPGRGSPQEGGSHVGRRPPEPTSSAAAAADAFLHVSHSSSDIRQGPGARPLKAILPCSSSAPPLPPKPKVAAPAAVKSPEAEAAEPAGGVGRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 548, "header": "tr|A0AAF7ALD7-1|A0AAF7ALD7_BOVIN Computationally mapped isoform of Protein FAM110B OS=Bos taurus OX=9913 GN=FAM110B PE=3 SV=1 CANONICAL=Q2KJ38-1" }, "locus": { "chromosome": "14", "start_pos": 24432259, "end_pos": 24310354, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068055.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068055.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071055.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071055.2" } ] } }, { "isoform_ac": "Q2KJ38-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38/entry#Q2KJ38-1", "sequence": { "sequence": "MPTESLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKGFGGGGGGAKSEGGAPRETLKLEILKNILNSSEGSSTGSGHKHSARNWPAPRADAAELHRHSFAESLRARPAPGRGSPQEGGSHVGRRPPEPTSSAAAAADAFLHVSHSSSDIRQGPGARPLKAILPCSSSAPPLPPKPKVAAPAAVKSPEAEAAEPAGGVGRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 380, "header": "sp|Q2KJ38-1|F110B_BOVIN Isoform 1 of Protein FAM110B OS=Bos taurus OX=9913 GN=FAM110B PE=2 SV=1 CANONICAL=Q2KJ38-1" }, "locus": { "chromosome": "14", "start_pos": 24432259, "end_pos": 24431120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088630.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088630.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 192, "start_aa": "Thr", "end_pos": 192, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr192", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 248, "end_pos": 248, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "site_lbl": "Ser248" }, { "start_pos": 311, "end_pos": 311, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "site_lbl": "Ser311" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767946", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767946", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NWR5-1", "protein_name": "Protein FAM110B", "gene_name": "FAM110B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPTETLPTGSMVKPVSPAVTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFSNNAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHGPRNWPPHRADSTELNRHSFAESLKVYPTQGRSSPQESSSNVSRRLLDQSAETFLHVSHSSSDIRKVTSAKPLKAIPCSSSAPPLPPKPKIAAIATLKSPEIEAVESGCGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 370 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RT69-1", "protein_name": "Protein FAM110B", "gene_name": "FAM110B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPTESLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVLGGGAKPEGGAPRETLKLEILKNILNSSEGSSAGSAHKHGARNWPAARADAAELHRHSFAESLRLCPTPGRGSPQEGGSHVGRRLLEPAADAVLHVSHSSSDIRRVGGKPPRAVACSSSAPPLPPKPKAAAAAPAALKSPEAEAAEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 371 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HD62-1", "protein_name": "Protein FAM110B", "gene_name": "Fam110b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRTLGSPTLKVFGNHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTDLHRHSFAESLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKVAAMKSPEADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 366 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4QRD7-1", "protein_name": "Protein FAM110B", "gene_name": "fam110b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPTETLQADSKPVGQGGAFASAVPLRILNKGPDYFRRQTEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPIKPQVLAKPPVCPVPLKRGGGVGSGLKASNNNAKSDTCATTTKRENLNLEILKNILNSSSSSEGPAKGTSHKVGARSWAPHRSSELSEPGCRSFTDSLKVPPSTQGRHSPQGGNLNLSRRLLEERSCEVDGERSPLHASHSSSDIRRMCNGKPLRAARSSSSSAPPLPPKPSAKALAACDNAPCSPERETLTSTAAELELGSSVARRPSLHRSKSDLSDRYARAGADVERFFNYCGLDPEELESVGVESFARANSDIVSLNFRSASMISSDCEQSRHSNDDLTDEEDDAGERVPYGISAVERNARIIKWLYSIKQARESQKVSHV", "length": 397 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5BJX5-1", "protein_name": "Protein FAM110B", "gene_name": "Fam110b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFGNHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAESLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 366 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C739-1", "protein_name": "Protein FAM110B", "gene_name": "Fam110b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGTKRALGSPTLKVFGNHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTDLHRHSFAESLKVYPTPGHGSPQESSSHVSRRLLEQSAETFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKVAAMKSPEADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 366 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TC76-1", "protein_name": "Protein FAM110B", "gene_name": "FAM110B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFGNHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFAESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV", "length": 370 }, "evidence": [ { "id": "Q2KJ38", "url": "https://omabrowser.org/oma/group/Q2KJ38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ38", "url": "https://www.uniprot.org/uniprotkb/Q2KJ38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ38" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 192 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 248, 311 ], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZA9-1", "uniprot_ac": "Q3SZA9", "uniprot_id": "RM35_BOVIN", "mass": { "chemical_mass": 21651.0, "monoisotopic_mass": 21651.0 }, "refseq": { "ac": "NP_001179320", "name": "large ribosomal subunit protein bL35m", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" }, "gene_names": [ { "name": "MRPL35", "type": "recommended", "evidence": [ { "id": "Q3SZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ] }, { "name": "L35mt", "type": "synonym", "evidence": [ { "id": "NP_001179320", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" } ] }, { "name": "MRP-L35", "type": "synonym", "evidence": [ { "id": "NP_001179320", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" } ] }, { "name": "MRPL35", "type": "synonym", "evidence": [ { "id": "NP_001179320", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein bL35m", "type": "recommended", "evidence": [ { "id": "Q3SZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L35, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001179320", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" }, { "id": "Q3SZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#names_and_taxonomy" } ] }, { "name": "L35mt", "type": "synonym", "evidence": [ { "id": "Q3SZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#names_and_taxonomy" } ] }, { "name": "MRP-L35", "type": "synonym", "evidence": [ { "id": "Q3SZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein bL35m", "type": "synonym", "evidence": [ { "id": "NP_001179320", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL35", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9", "locus": { "chromosome": "11", "start_pos": 48659108, "end_pos": 48665790, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004823", "url": "https://www.ensembl.org/id/ENSBTAG00000004823" } ] } } ], "crossref": [ { "id": "Q3SZA9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004823", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004823", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540278", "url": "https://www.ncbi.nlm.nih.gov/gene/540278", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037229", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037229", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540278", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540278", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TYCSTRK", "url": "https://omabrowser.org/oma/group/TYCSTRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZA9", "url": "https://www.orthodb.org/?gene=Q3SZA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15909:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15909:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179320", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T630", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T630", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T630-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T630-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASMFAGAVRAASGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRMALLLPNVLKPPVRTVTYCSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTVARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQMYHDRTNLKV", "length": 188, "header": "sp|Q3SZA9-1|RM35_BOVIN Isoform 1 of Large ribosomal subunit protein bL35m OS=Bos taurus OX=9913 GN=MRPL35 PE=2 SV=2 CANONICAL=Q3SZA9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T630-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#A0AAA9T630-1", "sequence": { "sequence": "MHEIQAVCRGCAYLVPSVPVQGVLRETGVKDCLHSEDFCKGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRMALLLPNVLKPPVRTVTYCSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTVARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQMYHDRTNLKV", "length": 214, "header": "tr|A0AAA9T630-1|A0AAA9T630_BOVIN Computationally mapped isoform of Large ribosomal subunit protein bL35m OS=Bos taurus OX=9913 GN=MRPL35 PE=3 SV=1 CANONICAL=Q3SZA9-1" }, "locus": { "chromosome": "11", "start_pos": 48665249, "end_pos": 48659474, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087903.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087903.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092015.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092015.1" } ] } }, { "isoform_ac": "A0AAA9TEW8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#A0AAA9TEW8-1", "sequence": { "sequence": "MNPFCATLLSLQGAYTCFSLSAGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRMALLLPNVLKPPVRTVTYCSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTVARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQMYHDRTNLKV", "length": 196, "header": "tr|A0AAA9TEW8-1|A0AAA9TEW8_BOVIN Computationally mapped isoform of Large ribosomal subunit protein bL35m OS=Bos taurus OX=9913 GN=MRPL35 PE=3 SV=1 CANONICAL=Q3SZA9-1" }, "locus": { "chromosome": "11", "start_pos": 48664403, "end_pos": 48659474, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094783.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094783.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095378.1" } ] } }, { "isoform_ac": "A0AAA9TIW6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#A0AAA9TIW6-1", "sequence": { "sequence": "MAASMFAGAVRAASGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRLVIRKNYGKRRLQEKDA", "length": 95, "header": "tr|A0AAA9TIW6-1|A0AAA9TIW6_BOVIN Computationally mapped isoform of Mitochondrial ribosomal protein L35 OS=Bos taurus OX=9913 GN=MRPL35 PE=4 SV=1 CANONICAL=Q3SZA9-1" }, "locus": { "chromosome": "11", "start_pos": 48665769, "end_pos": 48659608, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104278.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104278.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098265.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098265.1" } ] } }, { "isoform_ac": "A0AAA9TKA0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#A0AAA9TKA0-1", "sequence": { "sequence": "MLGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRMALLLPNVLKPPVRTVTYCSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTVARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQMYHDRTNLKV", "length": 176, "header": "tr|A0AAA9TKA0-1|A0AAA9TKA0_BOVIN Computationally mapped isoform of Large ribosomal subunit protein bL35m OS=Bos taurus OX=9913 GN=MRPL35 PE=3 SV=1 CANONICAL=Q3SZA9-1" }, "locus": { "chromosome": "11", "start_pos": 48664550, "end_pos": 48659474, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133701.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133701.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096687.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096687.1" } ] } }, { "isoform_ac": "Q3SZA9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9/entry#Q3SZA9-1", "sequence": { "sequence": "MAASMFAGAVRAASGILRPLNILASSAYRNCTKNACLNSILSSRHFSHIQTPVVSSAPRLITSVRNLTCGQTATVLNRMALLLPNVLKPPVRTVTYCSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTVARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQMYHDRTNLKV", "length": 188, "header": "sp|Q3SZA9-1|RM35_BOVIN Isoform 1 of Large ribosomal subunit protein bL35m OS=Bos taurus OX=9913 GN=MRPL35 PE=2 SV=2 CANONICAL=Q3SZA9-1" }, "locus": { "chromosome": "11", "start_pos": 48665769, "end_pos": 48659474, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006331.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006331.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006331.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006331.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540278", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540278", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QZK0-1", "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "MRPL35", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASAFAGAVRAATGILRPLHILASSAYQNCAKNACLSSVLSSRHFSHIQTSALLSAPRLITSVRNLMCGPTAPVLNRVAPLLPHVLKPPVRTVTYFSSRKGKRKTVKAVIYRFLRLHSGLWLRRKAGYKKKLWKKTAARKRRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYQKYQDRTNLKV", "length": 188 }, "evidence": [ { "id": "Q3SZA9", "url": "https://omabrowser.org/oma/group/Q3SZA9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MF78-1", "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "Mrpl35", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAASVFTGALRAASGILRPLNVLASSTYRNYAKNACLTSALCTIHFRHIQTPVVSFAPRLVTSVRNLTHGHTATVLNRVAALVPSVLKPPVRTLTYCSTRKGKRKTVKSVVHRFLRLHSGLWLRRKAGYKKKLWKKSTARKKRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYLMYHDRTNLRV", "length": 188 }, "evidence": [ { "id": "Q3SZA9", "url": "https://omabrowser.org/oma/group/Q3SZA9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I5ZYT3-1", "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "Mrpl35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "HSSRHQEALHQQRILRPLNVSVSSTYRNCARNACLSSALRTIPFRHIQTSVVSSAPRLVKSVGHLAYGHTASVLNRVATLVPSVLKPPVRALTYCSARKGKRKTVKSVVHRFLRLHSGLWLRRKAGYKKKLWKKSTARKKRLREFVFCNKTQSKLLDKMTTSFWKRRNWYTGDPYQMYHDRTNLRV", "length": 186 }, "evidence": [ { "id": "Q3SZA9", "url": "https://omabrowser.org/oma/group/Q3SZA9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQL6-1", "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "Mrpl35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASIFTGAVRAASGIFRPLNVLASSTYRNCARNACLNSSLCTIHFRHIQTSVVSSAPRLVTSVGHLAYGHTTTVLNRVATLVPSVLKPPVRALTYCSTRKGKRKTVKSVVHRFLRLHSGLWLRRKAGYKKKLWKKSTARKKRLREFVFCSKTQSKLLDKMTTSFWKRRNWYAGDPYQMYHDRTNLRV", "length": 188 }, "evidence": [ { "id": "Q3SZA9", "url": "https://omabrowser.org/oma/group/Q3SZA9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZE8-1", "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "MRPL35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLPVRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKAGYKKKLWKKTPARKKRLREFVFCNKTQSKLLDKMTTSFWKRRNWYVDDPYQKYHDRTNLKV", "length": 188 }, "evidence": [ { "id": "Q3SZA9", "url": "https://omabrowser.org/oma/group/Q3SZA9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" }, { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA9", "url": "https://www.uniprot.org/uniprotkb/Q3SZA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZA9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZA9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZA9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0S3-1", "uniprot_ac": "Q3T0S3", "uniprot_id": "TSN1_BOVIN", "mass": { "chemical_mass": 26208.0, "monoisotopic_mass": 26208.0 }, "refseq": { "ac": "NP_001029442", "name": "tetraspanin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029442" }, "gene_names": [ { "name": "TSPAN1", "type": "recommended", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ] }, { "name": "TSPAN1", "type": "synonym", "evidence": [ { "id": "NP_001029442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029442" } ] } ], "protein_names": [ { "name": "Tetraspanin-1", "type": "recommended", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3/entry#names_and_taxonomy" } ] }, { "name": "Tspan-1", "type": "synonym", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-1", "type": "synonym", "evidence": [ { "id": "NP_001029442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029442" } ] }, { "name": "tspan-1", "type": "synonym", "evidence": [ { "id": "NP_001029442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029442" } ] } ], "function": [ { "annotation": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7X5#function" }, { "database": "UniProtKB", "id": "ARBA00054958", "url": "https://www.uniprot.org/uniprotkb/ARBA00054958#function" }, { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#function" }, { "database": "UniProtKB", "id": "Q6AYR9", "url": "https://www.uniprot.org/uniprotkb/Q6AYR9#function" }, { "database": "UniProtKB", "id": "O60635", "url": "https://www.uniprot.org/uniprotkb/O60635#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN1", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3", "locus": { "chromosome": "3", "start_pos": 99895916, "end_pos": 99901006, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013320", "url": "https://www.ensembl.org/id/ENSBTAG00000013320" } ] } } ], "crossref": [ { "id": "Q3T0S3", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013320", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013320", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506550", "url": "https://www.ncbi.nlm.nih.gov/gene/506550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506550", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506550", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYGAHTE", "url": "https://omabrowser.org/oma/group/CYGAHTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0S3", "url": "https://www.orthodb.org/?gene=Q3T0S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T7X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0S3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCFNFIKVMMILFNMLIFLCGAALLAVGIWVSVDGPSFVKIFGPMSSSAMQFVNVGYFLIAAGAVLFALGFLGCYGAQTESKCALMTFFFILLLIFIAEVAAAVVALVYTTLAENFLTAVVVPNIKKEYGSQKDFTQVWNSTMAGLKCCGFTNYTDFEGSPYVRKNGTFPPYCCYDSVNNSFMEPCNNFTAHNMSVQGCFKQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLE", "length": 241, "header": "sp|Q3T0S3-1|TSN1_BOVIN Isoform 1 of Tetraspanin-1 OS=Bos taurus OX=9913 GN=TSPAN1 PE=2 SV=1 CANONICAL=Q3T0S3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7X5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3/entry#A0AAA9T7X5-1", "sequence": { "sequence": "LWCLNFHFLPLCPQLCGAALLAVGIWVSVDGPSFVKIFGPMSSSAMQFVNVGYFLIAAGAVLFALGFLGCYGAQTESKCALMTFFFILLLIFIAEVAAAVVALVYTTLAENFLTAVVVPNIKKEYGSQKDFTQVWNSTMAGLKCCGFTNYTDFEGSPYVRKNGTFPPYCCYDSVNNSFMEPCNNFTAHNMSVQGCFKQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLE", "length": 236, "header": "tr|A0AAA9T7X5-1|A0AAA9T7X5_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN1 PE=3 SV=1 CANONICAL=Q3T0S3-1" }, "locus": { "chromosome": "3", "start_pos": 99898331, "end_pos": 99896344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094039.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094039.1" } ] } }, { "isoform_ac": "Q3T0S3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3/entry#Q3T0S3-1", "sequence": { "sequence": "MGCFNFIKVMMILFNMLIFLCGAALLAVGIWVSVDGPSFVKIFGPMSSSAMQFVNVGYFLIAAGAVLFALGFLGCYGAQTESKCALMTFFFILLLIFIAEVAAAVVALVYTTLAENFLTAVVVPNIKKEYGSQKDFTQVWNSTMAGLKCCGFTNYTDFEGSPYVRKNGTFPPYCCYDSVNNSFMEPCNNFTAHNMSVQGCFKQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLE", "length": 241, "header": "sp|Q3T0S3-1|TSN1_BOVIN Isoform 1 of Tetraspanin-1 OS=Bos taurus OX=9913 GN=TSPAN1 PE=2 SV=1 CANONICAL=Q3T0S3-1" }, "locus": { "chromosome": "3", "start_pos": 99900413, "end_pos": 99896344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017715.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017715.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017715.2", "url": "https://www.ensembl.org/id/ENSBTAP00000017715.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 141, "start_aa": "Asn", "end_pos": 141, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn141", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 154, "start_aa": "Asn", "end_pos": 154, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn154", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 189, "start_aa": "Asn", "end_pos": 189, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn189", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 194, "start_aa": "Asn", "end_pos": 194, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn194", "evidence": [ { "id": "Q3T0S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 214, "start_aa": "Thr", "end_pos": 214, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr214", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506550", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506550", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LY71-1", "protein_name": "Tetraspanin", "gene_name": "Tspan1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKCFRFIKVMMILFNLLIFLCGAALLAVGIWVSVDGTSFLKIFGSQSSSALQFVNVGYFLIAAGAVVFILGFLGCYGAHSENKCALMMFFVILLIIFIAEIAAAVVALVYTTMAEQFLTLLVVPAIRDDYGNQTEFTNVWNSTMEGLKCCGFNGYTDFNNSSYLKETSFFPPYCCFNSTSGILEKPCNEEKAKQLEVQGCFKQLLHSIRTNAVTAGGVAVGIAALELAAMIVSMYLYCNLE", "length": 241 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M6Z7L3-1", "protein_name": "Tetraspanin", "gene_name": "tspan1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGCFTFVKALMVMFNLLICLAGICVATVGIWATVYENSFMNILPPFNDKIWSHVNVGIFCICIGAVMTWLGMIGCCGAQKESKCLLIMFFSIVLIICIAEVAAAVVTLVYSSYAEIFLRLWAIPGLKEQYGKNQIFTNLWNSTMTTLQCCGFNNYTDFSGSYYYMQNGELYPPACCLGLELFPCDEDNADYSRVMGCFKRIVKNTKMNVNIVGGIAAGVTAIELAAMGVAMYLYCYLDKKET", "length": 242 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S3V5-1", "protein_name": "Tetraspanin", "gene_name": "TSPAN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRCFSFIKTVMILFNLLIFLCGAALLAVGIWVSVDGPSFMKVFGPLSSSAMQFVNVGYFLIAAGAVLFALGFLGCYGAQTENKCALMMFFFILLLIFIAEIAAAVVALVYTSMAEHFLTLLVVPAIKKDYGSQKDFTQVWNSTMEGLKCCGFNNYTDFEGSPYYTENKVFPPYCCFDPGNGTAVEPCTRDEAQNKTVQGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLK", "length": 241 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O60635-1", "protein_name": "Tetraspanin-1", "gene_name": "TSPAN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ", "length": 241 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYR9-1", "protein_name": "Tetraspanin-1", "gene_name": "Tspan1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQCFKFIKVMMILFNLLIFLCGAALLAVGIWVSVDGTSFLKAFGSLSSSAMQFVNVGYFLIAAGAVLFILGFLGCYGAHSENKCVLMMFFSILLIIFIAEIAGAVVALVYTTMAEQFLTFLVVPAIEKDYGYQTEFTQVWNSTMEGLHCCGFNNYTDFNSSRFVKENKVFPPFCCANNTDSHTVEPCTEDKAKSMNVQGCFKQILQKIRTNAVTVGGVAVGVAALELAAMVVSMYLYCNLK", "length": 241 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99J59-1", "protein_name": "Tetraspanin-1", "gene_name": "Tspan1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQCFKFIKVMMFLFNLLIFLCGAALLAVGIWVSVDGTSFLKVFGSLSSSAMQFVNVGYFLIAAGAVLFILGFLGCYGAHSENKCVLMMFFSILLIIFIAEIAGAVVALVYTTLAEQFLTLLVVPAIEKDYGYQTDFTQVWNTTMEELHCCGFNNYTDFNASRFVKENKVFPPPCCANPGNHTVEPCTEEKAKSMKVQGCFKEILHRIRANAVTVGGVAVGVAALELAAMVVSMYLYCNLK", "length": 240 }, "evidence": [ { "id": "Q3T0S3", "url": "https://omabrowser.org/oma/group/Q3T0S3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q3T0S3", "url": "https://www.uniprot.org/uniprotkb/Q3T0S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0S3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0S3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0S3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 141, 154, 167, 180, 189, 194 ], "o_linked_sites": [ 214 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 189, "end_pos": 191 }, { "start_pos": 194, "end_pos": 196 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T020-1", "uniprot_ac": "Q3T020", "uniprot_id": "TCAL8_BOVIN", "mass": { "chemical_mass": 13592.0, "monoisotopic_mass": 13592.0 }, "refseq": { "ac": "NP_001070584", "name": "transcription elongation factor A protein-like 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" }, "gene_names": [ { "name": "LOC132342093", "type": "recommended", "evidence": [ { "id": "Q3T020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T020" } ] }, { "name": "TCEAL8", "type": "recommended", "evidence": [ { "id": "Q3T020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T020" } ] }, { "name": "TCEAL8", "type": "synonym", "evidence": [ { "id": "NP_001070584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" } ] } ], "protein_names": [ { "name": "Transcription elongation factor A protein-like 8", "type": "recommended", "evidence": [ { "id": "Q3T020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T020/entry#names_and_taxonomy" } ] }, { "name": "TCEA-like protein 8", "type": "synonym", "evidence": [ { "id": "NP_001070584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" }, { "id": "Q3T020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T020/entry#names_and_taxonomy" } ] }, { "name": "Transcription elongation factor S-II protein-like 8", "type": "synonym", "evidence": [ { "id": "Q3T020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T020/entry#names_and_taxonomy" } ] }, { "name": "transcription elongation factor A (SII)-like 8", "type": "synonym", "evidence": [ { "id": "NP_001070584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" } ] }, { "name": "transcription elongation factor A protein-like 8", "type": "synonym", "evidence": [ { "id": "NP_001070584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" } ] }, { "name": "transcription elongation factor S-II protein-like 8", "type": "synonym", "evidence": [ { "id": "NP_001070584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "Q3T020", "url": "https://www.uniprot.org/uniprotkb/Q3T020#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T020", "url": "https://www.uniprot.org/uniprotkb/Q3T020" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCEAL8", "url": "https://www.uniprot.org/uniprotkb/Q3T020", "locus": { "chromosome": "X", "start_pos": 52184709, "end_pos": 52200982, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027843", "url": "https://www.ensembl.org/id/ENSBTAG00000027843" } ] } } ], "crossref": [ { "id": "Q3T020", "url": "https://alphafold.ebi.ac.uk/entry/Q3T020", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027843", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027843", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768059", "url": "https://www.ncbi.nlm.nih.gov/gene/768059", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768059", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768059", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QTSCEEN", "url": "https://omabrowser.org/oma/group/QTSCEEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T020", "url": "https://www.orthodb.org/?gene=Q3T020", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF04538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TA11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T020", "url": "https://www.uniprot.org/uniprotkb/Q3T020", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T020-1", "url": "https://www.uniprot.org/uniprotkb/Q3T020-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKSCGENERKPQNMPKAEEDRPLEAVPQEAEGNPQPSEEGVSQEAEGNLRGGLTQPGQGYKEDSPVRHLDPEEMIRGADELERLREEIRRVRNKFVMMHWKQRHSRSRPYPVCFRP", "length": 117, "header": "sp|Q3T020-1|TCAL8_BOVIN Isoform 1 of Transcription elongation factor A protein-like 8 OS=Bos taurus OX=9913 GN=TCEAL8 PE=3 SV=1 CANONICAL=Q3T020-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TA11-1", "url": "https://www.uniprot.org/uniprotkb/Q3T020/entry#A0AAA9TA11-1", "sequence": { "sequence": "MRTWGNFRGTRPRIVQGTRDSGTDLLTKQSCRSAGLLVFGERPKSTEGRGRKIPWIPAGLIYSKRKSKNTQPSEEGVSQEAEGNLRGGLTQPGQGYKEDSPVRHLDPEEMIRGADELERLREEIRRVRNKFVMMHWKQRHSRSRPYPVCFRP", "length": 152, "header": "tr|A0AAA9TA11-1|A0AAA9TA11_BOVIN Computationally mapped isoform of Transcription elongation factor A like 8 OS=Bos taurus OX=9913 GN=LOC132342093 PE=4 SV=1 CANONICAL=Q3T020-1" }, "locus": { "chromosome": "X", "start_pos": 52186817, "end_pos": 52185632, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101638.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101638.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093714.1" } ] } }, { "isoform_ac": "Q3T020-1", "url": "https://www.uniprot.org/uniprotkb/Q3T020/entry#Q3T020-1", "sequence": { "sequence": "MQKSCGENERKPQNMPKAEEDRPLEAVPQEAEGNPQPSEEGVSQEAEGNLRGGLTQPGQGYKEDSPVRHLDPEEMIRGADELERLREEIRRVRNKFVMMHWKQRHSRSRPYPVCFRP", "length": 117, "header": "sp|Q3T020-1|TCAL8_BOVIN Isoform 1 of Transcription elongation factor A protein-like 8 OS=Bos taurus OX=9913 GN=TCEAL8 PE=3 SV=1 CANONICAL=Q3T020-1" }, "locus": { "chromosome": "X", "start_pos": 52185982, "end_pos": 52185632, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048145.3", "url": "https://www.ensembl.org/id/ENSBTAT00000048145.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000045234.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768059", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768059", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F2Z573-1", "protein_name": "Transcription elongation factor A like 8", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQKSCEENEGKSQNMPKAEEDRPLEDVPQEAERNPQPSEEGVSQEAEGNLGTGLTQPSQGYKEDTPVRHLDPEEMIRGVDELERLREEIRRVRNKFVMMHWKQRHSRSRPYPVCFRP", "length": 117 }, "evidence": [ { "id": "Q3T020", "url": "https://omabrowser.org/oma/group/Q3T020/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6I7R5-1", "protein_name": "Transcription elongation factor A protein-like 8", "gene_name": "Tceal8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQKSCDENEGTPQNTPKADEGHPSEDPPQQAGENLQASGENVREETDGSLRGEPAEPSPEPKEDTPARHLNPEEVIRGVDELERLREEIRRVRNKFVLMHWKQRHSRSRPYPVCFRP", "length": 117 }, "evidence": [ { "id": "Q3T020", "url": "https://omabrowser.org/oma/group/Q3T020/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IYN2-1", "protein_name": "Transcription elongation factor A protein-like 8", "gene_name": "TCEAL8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKSCEENEGKPQNMPKAEEDRPLEDVPQEAEGNPQPSEEGVSQEAEGNPRGGPNQPGQGFKEDTPVRHLDPEEMIRGVDELERLREEIRRVRNKFVMMHWKQRHSRSRPYPVCFRP", "length": 117 }, "evidence": [ { "id": "Q3T020", "url": "https://omabrowser.org/oma/group/Q3T020/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZY2-1", "protein_name": "Transcription elongation factor A protein-like 8", "gene_name": "Tceal8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKSCDENEGTPQNTPKADEGHPSEDPPQQAGETLQASGENVREETEGSHRGEPAEPSPEPKEDTPARHLNPEEVIRGVDELERLREEIRRVRNKFVLMHWKQRHSRSRPYPVCFRP", "length": 117 }, "evidence": [ { "id": "Q3T020", "url": "https://omabrowser.org/oma/group/Q3T020/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T020", "url": "https://www.uniprot.org/uniprotkb/Q3T020" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3T020", "url": "https://www.uniprot.org/uniprotkb/Q3T020" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T020-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 117, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T020-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T020" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9L9-1", "uniprot_ac": "Q2T9L9", "uniprot_id": "T2FB_BOVIN", "mass": { "chemical_mass": 28446.0, "monoisotopic_mass": 28446.0 }, "refseq": { "ac": "NP_001033153", "name": "general transcription factor IIF subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" }, "gene_names": [ { "name": "GTF2F2", "type": "recommended", "evidence": [ { "id": "Q2T9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ] }, { "name": "GTF2F2", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" } ] } ], "protein_names": [ { "name": "General transcription factor IIF subunit 2", "type": "recommended", "evidence": [ { "id": "Q2T9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent helicase GTF2F2", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" } ] }, { "name": "TFIIF-beta", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" }, { "id": "Q2T9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#names_and_taxonomy" } ] }, { "name": "Transcription initiation factor IIF subunit beta", "type": "synonym", "evidence": [ { "id": "Q2T9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor IIF subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" } ] }, { "name": "general transcription factor IIF, polypeptide 2, 30kDa", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" } ] }, { "name": "transcription initiation factor IIF subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001033153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153" } ] } ], "function": [ { "annotation": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9#function" }, { "database": "UniProtKB", "id": "P13984", "url": "https://www.uniprot.org/uniprotkb/P13984#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF2F2", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9", "locus": { "chromosome": "12", "start_pos": 15418923, "end_pos": 15282784, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034495", "url": "https://www.ensembl.org/id/ENSBTAG00000034495" } ] } } ], "crossref": [ { "id": "Q2T9L9", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9L9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034495", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034495", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07980", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07980", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509259", "url": "https://www.ncbi.nlm.nih.gov/gene/509259", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509259", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509259", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIADNCY", "url": "https://omabrowser.org/oma/group/PIADNCY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9L9", "url": "https://www.orthodb.org/?gene=Q2T9L9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10445", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10445", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10445:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10445:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17683", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17683", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-113418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-113418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6803529", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803529", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72086", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72086", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72203", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73776", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73779", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75953", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77075", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77075", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9018519", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033153", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9L9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAANENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVSYLKDILKEIGVQNVKGIHKNTWELKPEYRHYQVEEKSD", "length": 249, "header": "sp|Q2T9L9-1|T2FB_BOVIN Isoform 1 of General transcription factor IIF subunit 2 OS=Bos taurus OX=9913 GN=GTF2F2 PE=2 SV=1 CANONICAL=Q2T9L9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#A0AAA9TDI7-1", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAANENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVLSRGIDPRGYTCWQKTLRCLPGWPPPVLCCNSVFLLECAKTDILIPSYFPACMD", "length": 264, "header": "tr|A0AAA9TDI7-1|A0AAA9TDI7_BOVIN Computationally mapped isoform of General transcription factor IIF subunit 2 OS=Bos taurus OX=9913 GN=GTF2F2 PE=3 SV=1 CANONICAL=Q2T9L9-1" }, "locus": { "chromosome": "12", "start_pos": 15411447, "end_pos": 15282843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123353.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123353.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094937.1" } ] } }, { "isoform_ac": "A0AAA9TEJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#A0AAA9TEJ3-1", "sequence": { "sequence": "MWRQWKQHSYLTSDKLTGVFGGNLLRIEFRCPHLETKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAANENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVLSRGIDPRGYTCWQKTLRCLPGWPPPVLCCNSVFLLECAKTDILIPSYFPACMD", "length": 279, "header": "tr|A0AAA9TEJ3-1|A0AAA9TEJ3_BOVIN Computationally mapped isoform of General transcription factor IIF subunit 2 OS=Bos taurus OX=9913 GN=GTF2F2 PE=3 SV=1 CANONICAL=Q2T9L9-1" }, "locus": { "chromosome": "12", "start_pos": 15411447, "end_pos": 15288976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102172.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102172.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096538.1" } ] } }, { "isoform_ac": "Q2T9L9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9/entry#Q2T9L9-1", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAANENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVSYLKDILKEIGVQNVKGIHKNTWELKPEYRHYQVEEKSD", "length": 249, "header": "sp|Q2T9L9-1|T2FB_BOVIN Isoform 1 of General transcription factor IIF subunit 2 OS=Bos taurus OX=9913 GN=GTF2F2 PE=2 SV=1 CANONICAL=Q2T9L9-1" }, "locus": { "chromosome": "12", "start_pos": 15418000, "end_pos": 15282843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048870.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048870.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045836.2", "url": "https://www.ensembl.org/id/ENSBTAP00000045836.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "site_lbl": "Ser142" }, { "start_pos": 248, "end_pos": 248, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "site_lbl": "Ser248" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509259", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509259", "resource": "KEGG Pathway" }, { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-113418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-113418", "resource": "Reactome", "description": "Formation of the Early Elongation Complex" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6796648", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-BTA-6803529", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803529", "resource": "Reactome", "description": "FGFR2 alternative splicing" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-BTA-72086", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72086", "resource": "Reactome", "description": "mRNA Capping" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" }, { "id": "R-BTA-72203", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "resource": "Reactome", "description": "Processing of Capped Intron-Containing Pre-mRNA" }, { "id": "R-BTA-73776", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "resource": "Reactome", "description": "RNA Polymerase II Promoter Escape" }, { "id": "R-BTA-73779", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "resource": "Reactome", "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-BTA-75953", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" }, { "id": "R-BTA-76042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" }, { "id": "R-BTA-77075", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77075", "resource": "Reactome", "description": "RNA Pol II CTD phosphorylation and interaction with CE" }, { "id": "R-BTA-9018519", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "resource": "Reactome", "description": "Estrogen-dependent gene expression" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SER4-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "GTF2F2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEELANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQYVLDMLFSAFEKHQYYNLKDLVDITKQPVSYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQAEEKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XGQ5-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "GTF2F2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSEKGELDLTGVKQNTGMWLVKVPKYLSQQWSKASGRGEVGKLRIAKNQGRTEVSFTLNEELASISDIGGKPAAVSAPREHPFLLQNVGGQTLTVFTESSTDKLSLEGIVVQRAECRPAASENYMKLKRFQIEESSKPVRLSQQLDKAVTTNYKPVANHQYNIEYEKKKKEDGKRARADKQQVLDMLFSAFEKHQYYNIKDLVDITKQPVIYLKEILREIGIYNVKGTHKNTWELKPEYRHYQVEDKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H834-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "Gtf2f2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQAEEKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P13984-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "GTF2F2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYRHYQGEEKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41900-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "TfIIFbeta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKEDKEKTQIIDKDLDLSNAGRGVWLVKVPKYIAQKWEKAPTNMDVGKLRINKTPGQKAQVSLSLTPAVLALDPEEKIPTEHILDVSQVTKQTLGVFSHMAPSDGKENSTTSAAQPDNEKLYMEGRIVQKLECRPIADNCYMKLKLESIRKASEPQRRVQPIDKIVQNFKPVKDHAHNIEYRERKKAEGKKARDDKNAVMDMLFHAFEKHQYYNIKDLVKITNQPISYLKEILKDVCDYNMKNPHKNMWELKKEYRHYKTEEKKEEEHKSGSSDSE", "length": 277 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q01750-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "Gtf2f2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMKLKRLQIEESSKPVRLSQQADKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQTEEKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R0A0-1", "protein_name": "General transcription factor IIF subunit 2", "gene_name": "Gtf2f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMKLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQTEEKSD", "length": 249 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LQZ4-1", "protein_name": "Transcription initiation factor IIF, beta subunit", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDIHNLDIEKSDRSIWLMKCPVVVDKAWHKIAASSSSSFASSDSPPDMAKIVREVDPLRDDSPPEFKMYMVGAEYGNMPKCYALNMFTDFVPMGGFSDVNQGCAAAEGKVDHKFDMKPYGETIEEYARLCRERTSKAMVKNRQIQVIDNDRGVHMRPMPGMLGLVSSNSKEKRKPPPVKQTEVKRTRRDRGELEAIMFKLFEGQPNWTLKQLVQETDQPAQFLKEILNELCVYNKRGSNQGTYELKPEYKKSAEDDTGGQ", "length": 261 }, "evidence": [ { "id": "Q2T9L9", "url": "https://omabrowser.org/oma/group/Q2T9L9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "pmid": "" }, { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "transcription factor TFIIF complex", "id": "GO:0005674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005674", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L9", "url": "https://www.uniprot.org/uniprotkb/Q2T9L9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9L9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9L9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9L9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 142, 248 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T061-1", "uniprot_ac": "Q3T061", "uniprot_id": "CO72L_BOVIN", "mass": { "chemical_mass": 12544.0, "monoisotopic_mass": 12544.0 }, "refseq": { "ac": "NP_001029867", "name": "cytochrome c oxidase subunit 7A2-like, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" }, "gene_names": [ { "name": "COX7A2L", "type": "recommended", "evidence": [ { "id": "Q3T061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ] }, { "name": "COX7A2L", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "SCAF1", "type": "synonym", "evidence": [ { "id": "Q3T061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3T061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T061/entry#names_and_taxonomy" } ] }, { "name": "Supercomplex assembly factor 1", "type": "synonym", "evidence": [ { "id": "Q3T061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T061/entry#names_and_taxonomy" } ] }, { "name": "cytochrome c oxidase subunit 7A-related protein, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "cytochrome c oxidase subunit 7A2-like, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "cytochrome c oxidase subunit 7A2-like, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "cytochrome c oxidase subunit VIIa polypeptide 2 like", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "cytochrome c oxidase subunit VIIa-related protein", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] }, { "name": "supercomplex assembly factor 1", "type": "synonym", "evidence": [ { "id": "NP_001029867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867" } ] } ], "function": [ { "annotation": "Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism. Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association. Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV (By similarity). Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (By similarity). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061#function" }, { "database": "UniProtKB", "id": "O14548", "url": "https://www.uniprot.org/uniprotkb/O14548#function" }, { "database": "UniProtKB", "id": "Q99KD6", "url": "https://www.uniprot.org/uniprotkb/Q99KD6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COX7A2L", "url": "https://www.uniprot.org/uniprotkb/Q3T061", "locus": { "chromosome": "11", "start_pos": 24756896, "end_pos": 24769506, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000705", "url": "https://www.ensembl.org/id/ENSBTAG00000000705" } ] } } ], "crossref": [ { "id": "Q3T061", "url": "https://alphafold.ebi.ac.uk/entry/Q3T061", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000705", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000705", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00928", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00928", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540225", "url": "https://www.ncbi.nlm.nih.gov/gene/540225", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540225", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540225", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KFNGITQ", "url": "https://omabrowser.org/oma/group/KFNGITQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T061", "url": "https://www.orthodb.org/?gene=Q3T061", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10510", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10510:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9707564", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029867", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TEV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHP6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T061-1", "url": "https://www.uniprot.org/uniprotkb/Q3T061-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYYKFSGFTQKLAGAWASDAYSPQGLRPVVSTEAPPIIFATPTKLSSGPTAYDYAGKNTVPELQKFFQKSDGVPIHLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPRNK", "length": 114, "header": "sp|Q3T061-1|CO72L_BOVIN Isoform 1 of Cytochrome c oxidase subunit 7A2-like, mitochondrial OS=Bos taurus OX=9913 GN=COX7A2L PE=3 SV=1 CANONICAL=Q3T061-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TEV7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T061/entry#A0AAA9TEV7-1", "sequence": { "sequence": "MYYKFSGFTQKLAGAWASDAYSPQGLRPVVSTEAPPIIFATPTKLSSGPTAYDYAGKNTVPELQKFFQVREDALEQRL", "length": 78, "header": "tr|A0AAA9TEV7-1|A0AAA9TEV7_BOVIN Computationally mapped isoform of Cytochrome c oxidase subunit 7A2 like OS=Bos taurus OX=9913 GN=COX7A2L PE=1 SV=1 CANONICAL=Q3T061-1" }, "locus": { "chromosome": "11", "start_pos": 24769203, "end_pos": 24758995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115834.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115834.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097127.1" } ] } }, { "isoform_ac": "A0AAF6YHP6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T061/entry#A0AAF6YHP6-1", "sequence": { "sequence": "RRVLRLRLRPTPGKAGSFSGAVARAVAAGSPHGASCIISSVASRRSWPEHGLPTPIALRVSEVHFRDQDIGTPAHSEEKTNSEGLRPVVSTEAPPIIFATPTKLSSGPTAYDYAGKNTVPELQKFFQKSDGVPIHLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPRNK", "length": 173, "header": "tr|A0AAF6YHP6-1|A0AAF6YHP6_BOVIN Computationally mapped isoform of Cytochrome c oxidase subunit 7A2 like OS=Bos taurus OX=9913 GN=COX7A2L PE=1 SV=1 CANONICAL=Q3T061-1" }, "locus": { "chromosome": "11", "start_pos": 24769307, "end_pos": 24757671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000943.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000943.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000943.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000943.3" } ] } }, { "isoform_ac": "Q3T061-1", "url": "https://www.uniprot.org/uniprotkb/Q3T061/entry#Q3T061-1", "sequence": { "sequence": "MYYKFSGFTQKLAGAWASDAYSPQGLRPVVSTEAPPIIFATPTKLSSGPTAYDYAGKNTVPELQKFFQKSDGVPIHLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPRNK", "length": 114, "header": "sp|Q3T061-1|CO72L_BOVIN Isoform 1 of Cytochrome c oxidase subunit 7A2-like, mitochondrial OS=Bos taurus OX=9913 GN=COX7A2L PE=3 SV=1 CANONICAL=Q3T061-1" }, "locus": { "chromosome": "11", "start_pos": 24769203, "end_pos": 24757671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100092.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100092.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087665.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540225", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540225", "resource": "KEGG Pathway" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-9707564", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "resource": "Reactome", "description": "Cytoprotection by HMOX1" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GHX2-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "Cox7a2l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYYKFSSFTQKLASAWASEAYTPQGFKPVSREAPPIIFATPTKLTSSVTAYDYAGKNKVPELQRFFQPPFLKSSLLQFGPLTNNGTSVQKADGVPIHLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASKPKNK", "length": 135 }, "evidence": [ { "id": "Q3T061", "url": "https://omabrowser.org/oma/group/Q3T061/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GV32-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "LOC100759281", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYYKFSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSSVTAYDYAGKNKVPELQKFFQKADGVPIHLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPKNK", "length": 114 }, "evidence": [ { "id": "Q3T061", "url": "https://omabrowser.org/oma/group/Q3T061/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O14548-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "COX7A2L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYYKFSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSDSTVYDYAGKNKVPELQKFFQKADGVPVYLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPKNK", "length": 114 }, "evidence": [ { "id": "Q3T061", "url": "https://omabrowser.org/oma/group/Q3T061/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61387-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "Cox7a2l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYYKFSSFTQKLAGAWASEAYTPQGLKPVSTEAPPIIFATPTKLTSSVTAYDYSGKNKVPELQKFFQKADGFHLKRGLPDQMLYRTTMALTLGGTIYCLIALYMASQPRNK", "length": 111 }, "evidence": [ { "id": "Q3T061", "url": "https://omabrowser.org/oma/group/Q3T061/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7SXI1-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "cox7a2l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYYKFSGFTQRLTGAASSTAYSPQGLRANVPSESPAMIFGTPTKLVSESSATVEYMGKNRVPDLQRIFQASDNIPVHLKRGVPDRLLYRSTMALTVGGVLYCLVALYLAAQPKKK", "length": 115 }, "evidence": [ { "id": "Q3T061", "url": "https://omabrowser.org/oma/group/Q3T061/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" }, { "name": "respiratory chain complex IV", "id": "GO:0045277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045277", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial electron transport, cytochrome c to oxygen", "id": "GO:0006123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006123", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" }, { "name": "regulation of oxidative phosphorylation", "id": "GO:0002082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002082", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" }, { "name": "mitochondrial respirasome assembly", "id": "GO:0097250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097250", "evidence": [ { "database": "UniProtKB", "id": "Q3T061", "url": "https://www.uniprot.org/uniprotkb/Q3T061" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T061-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 114, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T061-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T061" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZM3-1", "uniprot_ac": "Q3SZM3", "uniprot_id": "CYBC1_BOVIN", "mass": { "chemical_mass": 20905.0, "monoisotopic_mass": 20905.0 }, "refseq": { "ac": "NP_001071555", "name": "cytochrome b-245 chaperone 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" }, "gene_names": [ { "name": "CYBC1", "type": "recommended", "evidence": [ { "id": "Q3SZM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ] }, { "name": "C17orf62", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "C19H17orf62", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "CYBC1", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "EROS", "type": "synonym", "evidence": [ { "id": "Q3SZM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ] } ], "protein_names": [ { "name": "Cytochrome b-245 chaperone 1", "type": "recommended", "evidence": [ { "id": "Q3SZM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#names_and_taxonomy" } ] }, { "name": "Eros", "type": "synonym", "evidence": [ { "id": "Q3SZM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#names_and_taxonomy" } ] }, { "name": "Essential for reactive oxygen species protein", "type": "synonym", "evidence": [ { "id": "Q3SZM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#names_and_taxonomy" } ] }, { "name": "chromosome 19 C17orf62 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "cytochrome b-245 chaperone 1", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "eros", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "essential for reactive oxygen species protein", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] }, { "name": "uncharacterized protein C17orf62 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555" } ] } ], "function": [ { "annotation": "Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3#function" }, { "database": "UniProtKB", "id": "Q9BQA9", "url": "https://www.uniprot.org/uniprotkb/Q9BQA9#function" }, { "database": "UniProtKB", "id": "Q3TYS2", "url": "https://www.uniprot.org/uniprotkb/Q3TYS2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYBC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3", "locus": { "chromosome": "19", "start_pos": 50129900, "end_pos": 50122938, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018176", "url": "https://www.ensembl.org/id/ENSBTAG00000018176" } ] } } ], "crossref": [ { "id": "Q3SZM3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618343", "url": "https://www.ncbi.nlm.nih.gov/gene/618343", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618343", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618343", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKLFYIT", "url": "https://omabrowser.org/oma/group/WKLFYIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZM3", "url": "https://www.orthodb.org/?gene=Q3SZM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31837:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31837:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9THE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZS36", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZS36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZS36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZS36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZM3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYMQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVVLKTFSLYRKLLTLCRAGHDQVVVLLSDIRDVNVEEEKVRYFGKGYVVVLRFATGFSHPLTQSAVMGHRSDVEVIAKLITTFLELHRLESPVELSQSSDSEADSPGDQS", "length": 187, "header": "sp|Q3SZM3-1|CYBC1_BOVIN Isoform 1 of Cytochrome b-245 chaperone 1 OS=Bos taurus OX=9913 GN=CYBC1 PE=2 SV=1 CANONICAL=Q3SZM3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THE3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#A0AAA9THE3-1", "sequence": { "sequence": "MYMQVETRTSSRLHLKRAPGIRSWSLLVDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVVLKTFSLYRKLLTLCRAGHDQVVVLLSDIRDVNVEEEKVRYFGKGYVVVLRFATGFSHPLTQSAVMGHRSDVEVIAKLITTFLELHRLESPVELSQSSDSEADSPGDQS", "length": 173, "header": "tr|A0AAA9THE3-1|A0AAA9THE3_BOVIN Computationally mapped isoform of Essential for reactive oxygen species protein OS=Bos taurus OX=9913 GN=CYBC1 PE=3 SV=1 CANONICAL=Q3SZM3-1" }, "locus": { "chromosome": "19", "start_pos": 50127856, "end_pos": 50124149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097667.1" } ] } }, { "isoform_ac": "A0AAF6ZS36-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#A0AAF6ZS36-1", "sequence": { "sequence": "MYMQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVVLKTFSLYRKLLTLCRAGHDQVVVLLSDIRDVNVEEEKVRYFGKGYVVVLRFATGFSHPLTQSAVMGHRRSLQGTACAKSISGETHKASTLGMAW", "length": 173, "header": "tr|A0AAF6ZS36-1|A0AAF6ZS36_BOVIN Computationally mapped isoform of Essential for reactive oxygen species protein OS=Bos taurus OX=9913 GN=CYBC1 PE=3 SV=1 CANONICAL=Q3SZM3-1" }, "locus": { "chromosome": "19", "start_pos": 50129700, "end_pos": 50124149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078853.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078853.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056820.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056820.2" } ] } }, { "isoform_ac": "Q3SZM3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3/entry#Q3SZM3-1", "sequence": { "sequence": "MYMQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVVLKTFSLYRKLLTLCRAGHDQVVVLLSDIRDVNVEEEKVRYFGKGYVVVLRFATGFSHPLTQSAVMGHRSDVEVIAKLITTFLELHRLESPVELSQSSDSEADSPGDQS", "length": 187, "header": "sp|Q3SZM3-1|CYBC1_BOVIN Isoform 1 of Cytochrome b-245 chaperone 1 OS=Bos taurus OX=9913 GN=CYBC1 PE=2 SV=1 CANONICAL=Q3SZM3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 168, "end_pos": 168, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "site_lbl": "Ser168" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618343", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618343", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H9M3-1", "protein_name": "Essential for reactive oxygen species protein", "gene_name": "LOC100773571", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYMQVETRTSTRLHLTRAPGIRSWSLLVGILSTGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVILKTFSLYKKLLTLLRAGHDQVVVLLKDIQDVNVEEEKVRYFGKGYTVVLRFATGFSHPLTQSAVMGRRSDVEAIAKLITSFLELHRLESPSERSQSSDSEADGPGDQS", "length": 187 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1AM90-1", "protein_name": "Essential for reactive oxygen species protein", "gene_name": "CYBC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYMLIETRTSSLLHLTRSPGIRSWSVFVGIASIGLAAAYYSADSLAWKLFYMAGCFFVAAQNLEQWEEAVFDKNKGTVCLKTFNLYKKILTFSKGGSEQVVALLHEIRDVNVEEETVRYFGKGYLVVLRFVTGFSHPLTQSAVLGCRSDVEAVAKLVISFLELDRAESQDVYESSETEASDADEPQDEY", "length": 189 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S010-1", "protein_name": "Essential for reactive oxygen species protein", "gene_name": "CYBC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYMQVETRTSSCLHLKRAPGIRSWSLLVGIASIGLAAAYYSGDSLGWKLFYVSGCLFVAVQNLEDWQEAIFSKSTGKVVLKTSSLYRKLLTLCRAGHEQVVVQLSDIRDVSVEEEKVRYFGKGHVVVLRFATGFSHPLTQSAVMGHRGDVEAIARLITTFLELHRLESPAEPSQSSDSEADILGDHS", "length": 187 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TYS2-1", "protein_name": "Cytochrome b-245 chaperone 1", "gene_name": "Cybc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYMQVETRTSTRLHLKRAPGIRSWSLLVGILSTGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKNTGKVILKTFSLYKKLLTLLRAGHDQVVVLLKDIQDVNVEEEKVRYFGKGYMVVLRFATGFSHPLTQSAVMGRRSDVEAIAKLITSFLELHRLESPSERSQSSDSEPDGPGGQS", "length": 187 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYA6-1", "protein_name": "Cytochrome b-245 chaperone 1", "gene_name": "Cybc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYMQVETRTSTRLHLKRAPGIRSWSLLVGILSTGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFNKSTGKVILKTFSLYKKLLTLLRAGHDQVVVLLKDIQDVNVEEEKVRYFGKGYMVVLRFATGFSHPLTQSAVMGRRSDVEAIAKLITSFLELHRLESPSERSQSSDSEPDGPGGQS", "length": 187 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DGA7-1", "protein_name": "Cytochrome b-245 chaperone 1 homolog", "gene_name": "cybc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGYMIVEKHTSELLHLKRSPGIRSWSILVGIASVGLAAAYYSSDSILWKMFYVTGCFFVALQNMEEWEEAVFNKSKNEIELKTFSLYTMLLTLWKRGHEKVLLDLRHLRDVSVQEERVRYLGKGYLVVLRLATGFSYPLTQSATLGSRSDVEALAALLKRFLGLEELQQRLADDDYPDDDDGIEDLGLGDSSDSQDDPDGDDDEEH", "length": 206 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BQA9-1", "protein_name": "Cytochrome b-245 chaperone 1", "gene_name": "CYBC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYFGKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEAGDPASQS", "length": 187 }, "evidence": [ { "id": "Q3SZM3", "url": "https://omabrowser.org/oma/group/Q3SZM3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "pmid": "" }, { "name": "respiratory burst after phagocytosis", "id": "GO:0045728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045728", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM3", "url": "https://www.uniprot.org/uniprotkb/Q3SZM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 187, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZM3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 168 ], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZA0-1", "uniprot_ac": "Q3SZA0", "uniprot_id": "CSN4_BOVIN", "mass": { "chemical_mass": 46285.0, "monoisotopic_mass": 46285.0 }, "refseq": { "ac": "NP_001029866", "name": "COP9 signalosome complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" }, "gene_names": [ { "name": "COPS4", "type": "recommended", "evidence": [ { "id": "Q3SZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ] }, { "name": "COPS4", "type": "synonym", "evidence": [ { "id": "NP_001029866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" } ] } ], "protein_names": [ { "name": "COP9 signalosome complex subunit 4", "type": "recommended", "evidence": [ { "id": "Q3SZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#names_and_taxonomy" } ] }, { "name": "COP9 constitutive photomorphogenic homolog subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" } ] }, { "name": "COP9 signalosome complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" } ] }, { "name": "SGN4", "type": "synonym", "evidence": [ { "id": "NP_001029866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" }, { "id": "Q3SZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#names_and_taxonomy" } ] }, { "name": "Signalosome subunit 4", "type": "synonym", "evidence": [ { "id": "Q3SZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#names_and_taxonomy" } ] }, { "name": "signalosome subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866" } ] } ], "function": [ { "annotation": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0#function" }, { "database": "UniProtKB", "id": "Q9BT78", "url": "https://www.uniprot.org/uniprotkb/Q9BT78#function" }, { "database": "UniProtKB", "id": "A0AAF6YQK3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQK3#function" }, { "database": "UniProtKB", "id": "ARBA00045459", "url": "https://www.uniprot.org/uniprotkb/ARBA00045459#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COPS4", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0", "locus": { "chromosome": "6", "start_pos": 97875459, "end_pos": 97836181, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006950", "url": "https://www.ensembl.org/id/ENSBTAG00000006950" } ] } } ], "crossref": [ { "id": "Q3SZA0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006950", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006950", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540223", "url": "https://www.ncbi.nlm.nih.gov/gene/540223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540223", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540223", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNIMHTV", "url": "https://omabrowser.org/oma/group/KNIMHTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZA0", "url": "https://www.orthodb.org/?gene=Q3SZA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6781823", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013422", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013422", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029866", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9THX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQK3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVESMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406, "header": "sp|Q3SZA0-1|CSN4_BOVIN Isoform 1 of COP9 signalosome complex subunit 4 OS=Bos taurus OX=9913 GN=COPS4 PE=2 SV=1 CANONICAL=Q3SZA0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THX8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#A0AAA9THX8-1", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVESMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKHEKPCQHGTNRSSHSVSK", "length": 352, "header": "tr|A0AAA9THX8-1|A0AAA9THX8_BOVIN Computationally mapped isoform of COP9 signalosome complex subunit 4 OS=Bos taurus OX=9913 GN=COPS4 PE=3 SV=1 CANONICAL=Q3SZA0-1" }, "locus": { "chromosome": "6", "start_pos": 97875016, "end_pos": 97836463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129987.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129987.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095811.1" } ] } }, { "isoform_ac": "A0AAF6YQK3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#A0AAF6YQK3-1", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGNLSWAQLVDSSLLHMFLVPQGLHMHQIRYRQILEKAIQLSGAEQLEALKAFVESMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 433, "header": "tr|A0AAF6YQK3-1|A0AAF6YQK3_BOVIN Computationally mapped isoform of COP9 signalosome complex subunit 4 OS=Bos taurus OX=9913 GN=COPS4 PE=3 SV=1 CANONICAL=Q3SZA0-1" }, "locus": { "chromosome": "6", "start_pos": 97875093, "end_pos": 97836463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009128.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009128.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009128.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009128.5" } ] } }, { "isoform_ac": "Q3SZA0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0/entry#Q3SZA0-1", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVESMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406, "header": "sp|Q3SZA0-1|CSN4_BOVIN Isoform 1 of COP9 signalosome complex subunit 4 OS=Bos taurus OX=9913 GN=COPS4 PE=2 SV=1 CANONICAL=Q3SZA0-1" }, "locus": { "chromosome": "6", "start_pos": 97875093, "end_pos": 97836463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116597.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116597.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082771.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082771.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540223", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540223", "resource": "KEGG Pathway" }, { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" }, { "id": "R-BTA-6781823", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "resource": "Reactome", "description": "Formation of TC-NER Pre-Incision Complex" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9013422", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013422", "resource": "Reactome", "description": "RHOBTB1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XKL6-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "COPS4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAVRQELAQLMNSSGSHKDLAGKYRQILEKAIQLSGAQQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPSLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A7Y521-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "COPS4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IA32-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "Cops4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAVRQDLAQLMNLSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKVQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88544-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "Cops4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54B82-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "csn4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDVNNLKQILEETSALSDHKTKTEKYKSILQQLVESKQVAPLKVFITHLTDESTPLVISRTILLSFTSSHKTLPEDIQMELGIFVLDRIQNRVVAFEEQVSEIRYNLAKLYERQENWRESARCLIAIPLDSSQRVISPEYKVKIYVKIARLFLEEEESGQAETYINRASDSLHLVKNQKLILAHKTCFARIMDYKRMFLKASLRYYDLSQCLPKDTERMHALSCAIVCAILDKAGPQRSRTLATLYKDERSQQLGVYTFLEKMFLERILKKTEVKKFAEQLKPHQMALLSDGNTVLDRAVIEHNLLSASKLYNNITFDELGSLLEIQAEKAEKVASKMVCEERLIGSIDQIERLIQFENVGDSLTQWDKKIEGLCIHMNNIIESISKYPEFIV", "length": 393 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q68FS2-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "Cops4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKVQPRVISFEEQVASIRQRLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P0H6-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "cops4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASGVRQELAQLMNSSGSHKDLAGKYRQILEKALQFTDAEQLEALKAFVEAMVNENVSLVISRQLLTDFCAHLPNLPDDIAKVVCHFTLEKIQPRVISFEEQVASIRQHLATIYEKQEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHETERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPPAKAEKIASQMITEGRMNGFIDQIDGIVHFETREPLPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAIEAQMSQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8L5U0-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "CSN4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDEALTNASAIGDQRQKIEQYKLILSSVLSSNDLLQAQRFIDHILSDDVPLVVSRQLLQSFAQELGRLEPETQKEIAQFTLTQIQPRVVSFEEQALVIREKLAGLYESEQEWSKAAQMLSGIDLDSGMRAVDDNFKLSKCIQIARLYLEDDDAVNAEAFINKASFLVSNSQNEVLNLQYKVCYARILDMKRKFLEAALRYYGISQIEQRQIGDEEIDENALEQALSAAVTCTILAGAGPQRSRVLATLYKDERCSKLKIYPILQKVYLERILRRPEIDAFSEELRPHQKASLPDKSTVLDRAMIEHNLLSASKLYTNIRFDELGTLLAIDPRKAEKIAANMIGQDRMRGSIDQEEAVIHFEDDVEELQQWDQQISGLCQALNDILDGMAKKGMSVPV", "length": 397 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BT78-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "COPS4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "length": 406 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V345-1", "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "CSN4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAANYGISTAALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILNDVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELSYRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFENRELLPQWDRQIQSLCYQVNSIIEKISVAEPDWMDNLN", "length": 407 }, "evidence": [ { "id": "Q3SZA0", "url": "https://omabrowser.org/oma/group/Q3SZA0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" }, { "name": "COP9 signalosome", "id": "GO:0008180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein deneddylation", "id": "GO:0000338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000338", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA0", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZA0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 406, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZA0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZA0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA0" }, { "id": "PRU01185", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01185" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000255", "start_pos": 197, "end_pos": 366, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3B7N9-1", "uniprot_ac": "Q3B7N9", "uniprot_id": "MYNN_BOVIN", "mass": { "chemical_mass": 65412.0, "monoisotopic_mass": 65412.0 }, "refseq": { "ac": "NP_001030501", "name": "myoneurin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030501" }, "gene_names": [ { "name": "MYNN", "type": "recommended", "evidence": [ { "id": "Q3B7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ] }, { "name": "MYNN", "type": "synonym", "evidence": [ { "id": "NP_001030501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030501" } ] } ], "protein_names": [ { "name": "Myoneurin", "type": "recommended", "evidence": [ { "id": "Q3B7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9/entry#names_and_taxonomy" } ] }, { "name": "myoneurin", "type": "synonym", "evidence": [ { "id": "NP_001030501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030501" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYNN", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9", "locus": { "chromosome": "1", "start_pos": 97587928, "end_pos": 97604139, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013142", "url": "https://www.ensembl.org/id/ENSBTAG00000013142" } ] } } ], "crossref": [ { "id": "Q3B7N9", "url": "https://alphafold.ebi.ac.uk/entry/Q3B7N9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013142", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013142", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18217", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18217", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539376", "url": "https://www.ncbi.nlm.nih.gov/gene/539376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RPICNIC", "url": "https://omabrowser.org/oma/group/RPICNIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3B7N9", "url": "https://www.orthodb.org/?gene=Q3B7N9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030501", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TIE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2S1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2S1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2S1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7N9-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTKKKKKAFNSQKTGQNKTVQYPSDILENASVELFLDANKLSTPIIEQVAQRSNSELELTSVVENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIASVKNSYELESSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKILDSSIEDHPLNEQDSIQKSPLSETLDVKPSDVTLPLTLPLGAEDHHLLLPVADSQPPAPDALLRPAANGYSEPQLIFLQQLY", "length": 581, "header": "sp|Q3B7N9-1|MYNN_BOVIN Isoform 1 of Myoneurin OS=Bos taurus OX=9913 GN=MYNN PE=2 SV=1 CANONICAL=Q3B7N9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIE0-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9/entry#A0AAA9TIE0-1", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTKKKKKAFNSQKTGQNKTVQYPSDILENASVELFLDANKLSTPIIEQVAQRSNSELELTSVVENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIASVKNSYELESSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGADKILDSSIEDHPLNEQDSIQKSPLSETLDVKPSDVTLPLTLPLGAEDHHLLLPVADSQPPAPDALLRPAANGYSEPQLIFLQQLY", "length": 580, "header": "tr|A0AAA9TIE0-1|A0AAA9TIE0_BOVIN Computationally mapped isoform of Myoneurin OS=Bos taurus OX=9913 GN=MYNN PE=4 SV=1 CANONICAL=Q3B7N9-1" }, "locus": { "chromosome": "1", "start_pos": 97603083, "end_pos": 97589467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108528.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108528.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096675.1" } ] } }, { "isoform_ac": "A0AAA9U2S1-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9/entry#A0AAA9U2S1-1", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTKKKKKAFNSQKTGQNKTVQYPSDILENASVELFLDANKLSTPIIEQVAQRSNSELELTSVVENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIASVKNSYELESSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKILDSSIEDHPLNEQDSIQKSPLSETLDVKPSDVTLPLTLPLGAEDHHLLLPVADSQPPAPDALLRPAANGYSEPQLIFLQQLY", "length": 609, "header": "tr|A0AAA9U2S1-1|A0AAA9U2S1_BOVIN Computationally mapped isoform of Myoneurin OS=Bos taurus OX=9913 GN=MYNN PE=3 SV=1 CANONICAL=Q3B7N9-1" }, "locus": { "chromosome": "1", "start_pos": 97603083, "end_pos": 97589467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092038.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092038.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103956.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103956.1" } ] } }, { "isoform_ac": "Q3B7N9-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9/entry#Q3B7N9-1", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTKKKKKAFNSQKTGQNKTVQYPSDILENASVELFLDANKLSTPIIEQVAQRSNSELELTSVVENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIASVKNSYELESSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKILDSSIEDHPLNEQDSIQKSPLSETLDVKPSDVTLPLTLPLGAEDHHLLLPVADSQPPAPDALLRPAANGYSEPQLIFLQQLY", "length": 581, "header": "sp|Q3B7N9-1|MYNN_BOVIN Isoform 1 of Myoneurin OS=Bos taurus OX=9913 GN=MYNN PE=2 SV=1 CANONICAL=Q3B7N9-1" }, "locus": { "chromosome": "1", "start_pos": 97603083, "end_pos": 97589467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044888.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044888.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000042339.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 288, "end_pos": 288, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "site_lbl": "Ser288" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2000", "authors": "Alliel PM, Seddiqi N, Goudou D, Cifuentes-Diaz C, Romero N, Velasco E, Rieger F, Perin JP", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "reference": [ { "type": "PubMed", "id": "10873615", "url": "https://glygen.org/publication/PubMed/10873615" } ] } ], "pathway": [ { "id": "bta:539376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539376", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAA6-1", "protein_name": "Myoneurin", "gene_name": "Mynn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIASPSSTEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDSVQANPKQRVLTKKSSQSKKKKKAFNSQNPGRAKALQHHSGVSESASVELFLDANKLSPPAVEQVIQGNDTSELELTSVVENTFPAQDIVQTVTVKRKRRKSQSHCALKEHSMSNIASVKSPYELENAGEELDPRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGERPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGTDKNADCSVDDHAVSEQDSIQRSPLSETLDVKPSDMTLPLALPLGTEDHHMLLPVTDSQSPTSDTLLRSTVNGYSEPQLIFLQQLY", "length": 610 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A4X1VEG1-1", "protein_name": "Myoneurin", "gene_name": "MYNN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTKKKKKAFNSQKTRQNKTVQYPSDILENTSVELFLDANKLSTPIIEQVVQRNNSELELTSVVENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIATVKNSYELESSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGTDKILDSSIEDHPLSEKESIQKSPLSETLDVKPSDMALPLTLPLGTEDHHMLLPVTDNQSPTSDALLRSTVNGYSEPQLIFLQQLY", "length": 580 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LUK8-1", "protein_name": "Myoneurin", "gene_name": "Mynn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIASPSSTEISSITGNIELNQQTCLLTLRDYNNREKSDVSTDLVQANPKQRALAKKSSQSKKKKKAFNSQKPGQNKSVQYPSDALESTSVELFLDTNKLSPPVVEQVIQGNDNSELELTSVAENTFPAQDIVQTVTVKRKRGKSQSHCALKEHSMSNIASVKSPYELETVGEELDPRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGERPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGTDKTPDCSVDDHALSEQDPTQRSPLSETLDVKPSDMTLPLALPLGTEEHMLLPVTENQSPTSDTLLRSAVNGYSEPQLIFLQQLY", "length": 609 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YRJ1-1", "protein_name": "Myoneurin", "gene_name": "MYNN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTVVIGECQFKAHRNVLASFSEFFGAFYRDATDSTVVLDQTQVKADGFQKLLEFIYTGNLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTETSSITGNVEMNQQTCLLTLRDYNDREKADIPPAELVQPQAKKSALEKKSAQTKKRKKNFSSPKSVQNKSIQYQNDVTENTSIEMFLDANKLAAQITEQAAQGGDSSELQLAAVVESETLAAQDILVQTIAAKQKRGKPQQSCALKEHCMSNIASEKNAYQLESSGEELDQKYSKAKPVCNTCGKVFSEASSLRRHMRIHKGVKPYVCQLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHTGSETPPDCNTLDNSFNEQESLQSQKSPLSESVDVKPSEMSLPLPLPIGTEDHQMLLPVAGSQSPSSETLLRSAVTGYSEPQFIFLQQLY", "length": 615 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q99MD8-1", "protein_name": "Myoneurin", "gene_name": "Mynn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIASPSSTEISSITGNIELNQQACLLTLRDYNNREKSEVSTDSVQANPKPRALTKKSSQSKKKKKAFSSQKPGQSKAVQYPSDVLESASVELFLETSKLSSPVVEQIIQGNDSSELELTSVVENTFPTQDIVQTVTVKRKRRKSQSHCALKEHSMSNIASVKSPYELENAGEELDARFSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGERPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGTDKNPDCSVDDHAVSEQDSVQRSPLSETLDVKPSDMTLPLALPLGTEDHQMLLPVTDSQSPASDTLLRSTVNGYSEPQLIFLQQLY", "length": 610 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPC7-1", "protein_name": "Myoneurin", "gene_name": "MYNN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENASVELFLDANKLPTPVVEQVAQINDNSELELTSVVENTFPAQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKTLDSSAEDHTLSEQDSIQKSPLSETMDVKPSDMTLPLALPLGTEDHHMLLPVTDTQSPTSDTLLRSTVNGYSEPQLIFLQQLY", "length": 610 }, "evidence": [ { "id": "Q3B7N9", "url": "https://omabrowser.org/oma/group/Q3B7N9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3B7N9", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3B7N9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 581, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3B7N9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3B7N9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3B7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" }, { "id": "PRU00037", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 89, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3B7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N9" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 174, "end_pos": 190, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 288 ], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 206, "end_pos": 208 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHL8-1", "uniprot_ac": "Q3MHL8", "uniprot_id": "SMAP_BOVIN", "mass": { "chemical_mass": 20108.0, "monoisotopic_mass": 20108.0 }, "refseq": { "ac": "NP_001030551", "name": "small acidic protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030551" }, "gene_names": [ { "name": "C15H11orf58", "type": "recommended", "evidence": [ { "id": "Q3MHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ] }, { "name": "SMAP", "type": "recommended", "evidence": [ { "id": "Q3MHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ] }, { "name": "C15H11orf58", "type": "synonym", "evidence": [ { "id": "NP_001030551", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030551" } ] }, { "name": "SMAP", "type": "synonym", "evidence": [ { "id": "NP_001030551", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030551" } ] } ], "protein_names": [ { "name": "Small acidic protein", "type": "recommended", "evidence": [ { "id": "Q3MHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8/entry#names_and_taxonomy" } ] }, { "name": "small acidic protein", "type": "synonym", "evidence": [ { "id": "NP_001030551", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030551" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMAP", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8", "locus": {} } ], "crossref": [ { "id": "Q3MHL8", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006755", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006755", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616182", "url": "https://www.ncbi.nlm.nih.gov/gene/616182", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616182", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616182", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DIGSSNW", "url": "https://omabrowser.org/oma/group/DIGSSNW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHL8", "url": "https://www.orthodb.org/?gene=Q3MHL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22175", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22175", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22175:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22175:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030551", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U078", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U078", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U078-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U078-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHL8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVDDHDGEGDVAGDDDDDDSPDPESPDDSESDSESEKEESTEELQAAEHPDEVEDSKNKKDAKSNYKMMFVKSSGS", "length": 181, "header": "sp|Q3MHL8-1|SMAP_BOVIN Isoform 1 of Small acidic protein OS=Bos taurus OX=9913 GN=SMAP PE=2 SV=1 CANONICAL=Q3MHL8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TJD6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8/entry#A0AAA9TJD6-1", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKGKKTRKLMKNWSLNINKVWTVNYQEDIDDIVDLASVR", "length": 86, "header": "tr|A0AAA9TJD6-1|A0AAA9TJD6_BOVIN Computationally mapped isoform of Small acidic protein OS=Bos taurus OX=9913 GN=C15H11orf58 PE=3 SV=1 CANONICAL=Q3MHL8-1" }, "locus": { "chromosome": "15", "start_pos": 35715977, "end_pos": 35692012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098440.1" } ] } }, { "isoform_ac": "A0AAA9U078-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8/entry#A0AAA9U078-1", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKIFCGLKSASHIALNNCSKEKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVDDHDGEGDVAGDDDDDDSPDPESPDDSESDSESEKEESTEELQAAEHPDEVEDSKNKKDAKSNYKMMFVKSSGS", "length": 200, "header": "tr|A0AAA9U078-1|A0AAA9U078_BOVIN Computationally mapped isoform of Small acidic protein OS=Bos taurus OX=9913 GN=C15H11orf58 PE=3 SV=1 CANONICAL=Q3MHL8-1" }, "locus": { "chromosome": "15", "start_pos": 35715977, "end_pos": 35691788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097485.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097485.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102984.1" } ] } }, { "isoform_ac": "Q3MHL8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8/entry#Q3MHL8-1", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVDDHDGEGDVAGDDDDDDSPDPESPDDSESDSESEKEESTEELQAAEHPDEVEDSKNKKDAKSNYKMMFVKSSGS", "length": 181, "header": "sp|Q3MHL8-1|SMAP_BOVIN Isoform 1 of Small acidic protein OS=Bos taurus OX=9913 GN=SMAP PE=2 SV=1 CANONICAL=Q3MHL8-1" }, "locus": { "chromosome": "15", "start_pos": 35715977, "end_pos": 35691788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008884.3", "url": "https://www.ensembl.org/id/ENSBTAT00000008884.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008884.2", "url": "https://www.ensembl.org/id/ENSBTAP00000008884.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser125" }, { "start_pos": 145, "end_pos": 145, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser145" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser15" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser17" }, { "start_pos": 63, "end_pos": 63, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser63" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL8", "url": "https://www.uniprot.org/uniprotkb/Q3MHL8" } ], "site_lbl": "Ser87" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616182", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616182", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HU95-1", "protein_name": "Small acidic protein", "gene_name": "C3H11orf58", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDDDDSPDAESPDDSDSDSESEKEESAEELHATEHPDDAEDPKSKKDAKSNYKMMFVKSSGS", "length": 181 }, "evidence": [ { "id": "Q3MHL8", "url": "https://omabrowser.org/oma/group/Q3MHL8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LGJ9-1", "protein_name": "Small acidic protein", "gene_name": "C1h11orf58", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDEDDSPDAESPDDSDSDSESEKEESAEELHAAAHPDDTEDPKSKKDAKSSYKMMFVKSSGS", "length": 181 }, "evidence": [ { "id": "Q3MHL8", "url": "https://omabrowser.org/oma/group/Q3MHL8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O00193-1", "protein_name": "Small acidic protein", "gene_name": "SMAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDDDDDDSPDPESPDDSESDSESEKEESAEELQAAEHPDEVEDPKNKKDAKSNYKMMFVKSSGS", "length": 183 }, "evidence": [ { "id": "Q3MHL8", "url": "https://omabrowser.org/oma/group/Q3MHL8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0P4-1", "protein_name": "Small acidic protein", "gene_name": "Smap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDEDDSPDAESPDDSDSDSESEKEESAEELHAAEHPDDTEDPKSKKDAKSNYKMMFVKSSGS", "length": 181 }, "evidence": [ { "id": "Q3MHL8", "url": "https://omabrowser.org/oma/group/Q3MHL8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHL8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 181, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHL8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHL8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 15, 17, 63, 87, 125, 145 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBG9-1", "uniprot_ac": "Q2TBG9", "uniprot_id": "TM169_BOVIN", "mass": { "chemical_mass": 33288.0, "monoisotopic_mass": 33288.0 }, "refseq": { "ac": "NP_001033779", "name": "transmembrane protein 169", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033779" }, "gene_names": [ { "name": "TMEM169", "type": "recommended", "evidence": [ { "id": "Q2TBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9" } ] }, { "name": "TMEM169", "type": "synonym", "evidence": [ { "id": "NP_001033779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033779" } ] } ], "protein_names": [ { "name": "Transmembrane protein 169", "type": "recommended", "evidence": [ { "id": "Q2TBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 169", "type": "synonym", "evidence": [ { "id": "NP_001033779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033779" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBG9", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM169", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9", "locus": { "chromosome": "2", "start_pos": 104128350, "end_pos": 104115959, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010413", "url": "https://www.ensembl.org/id/ENSBTAG00000010413" } ] } } ], "crossref": [ { "id": "Q2TBG9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617045", "url": "https://www.ncbi.nlm.nih.gov/gene/617045", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617045", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617045", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AFSEWWQ", "url": "https://omabrowser.org/oma/group/AFSEWWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31777", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31777", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31777:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31777:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033779", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TJK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBG9", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBG9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEPALVEGQSQLPSPHHNSLRKAMAAALVLDGESTMGRRKKKKKESRPESIIIYRSESETLDEEPGESEGGDQPKEEEGDDFIDYPMDDGVWNVPVDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKASSRETTPGGRKACQLGADRGPHVVLWTLVCLPVVFLLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILCYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDATQEIETSAV", "length": 297, "header": "sp|Q2TBG9-1|TM169_BOVIN Isoform 1 of Transmembrane protein 169 OS=Bos taurus OX=9913 GN=TMEM169 PE=2 SV=1 CANONICAL=Q2TBG9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TJK6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9/entry#A0AAA9TJK6-1", "sequence": { "sequence": "MAFPMPVPPPVTMATWCCSKPAAKQLLPLTQEFTAITRLSNGGQGKLSHQGHACVAPPPLLRPAPLRHRAPSQSPTRHARRSGSVSLQCRTVPQRLHPDAQRSPPARVRSTCSATRHWNAFALAASWKKLCDVVGHEFALADWTLDKEQLDLKTRMEEPALVEGQSQLPSPHHNSLRKAMAAALVLDGESTMGRRKKKKKESRPESIIIYRSESETLDEEPGESEGGDQPKEEEGDDFIDYPMDDGVWNVPVDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKASSRETTPGGRKACQLGADRGPHVVLWTLVCLPVVFLLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILCYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDATQEIETSAV", "length": 452, "header": "tr|A0AAA9TJK6-1|A0AAA9TJK6_BOVIN Computationally mapped isoform of Transmembrane protein 169 OS=Bos taurus OX=9913 GN=TMEM169 PE=4 SV=1 CANONICAL=Q2TBG9-1" }, "locus": { "chromosome": "2", "start_pos": 104127822, "end_pos": 104115976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102814.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102814.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098647.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098647.1" } ] } }, { "isoform_ac": "A0AAA9TYF2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9/entry#A0AAA9TYF2-1", "sequence": { "sequence": "MYVTCFPAINLRAEPSKLRGLSHPPSPEVLLRIWMDLEKALDQVCFSDYLAAKNYKQTPGKSCPMGGVICISEVIEISPSNLDSSLCFIQPGISYDVLCIATRHWNAFALAASWKKLCDVVGHEFALADWTLDKEQLDLKTRMEEPALVEGQSQLPSPHHNSLRKAMAAALVLDGESTMGRRKKKKKESRPESIIIYRSESETLDEEPGESEGGDQPKEEEGDDFIDYPMDDGVWNVPVDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKASSRETTPGGRKACQLGADRGPHVVLWTLVCLPVVFLLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILCYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDATQEIETSAV", "length": 439, "header": "tr|A0AAA9TYF2-1|A0AAA9TYF2_BOVIN Computationally mapped isoform of Transmembrane protein 169 OS=Bos taurus OX=9913 GN=TMEM169 PE=4 SV=1 CANONICAL=Q2TBG9-1" }, "locus": { "chromosome": "2", "start_pos": 104127822, "end_pos": 104120901, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101675.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101675.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103380.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103380.1" } ] } }, { "isoform_ac": "Q2TBG9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9/entry#Q2TBG9-1", "sequence": { "sequence": "MEEPALVEGQSQLPSPHHNSLRKAMAAALVLDGESTMGRRKKKKKESRPESIIIYRSESETLDEEPGESEGGDQPKEEEGDDFIDYPMDDGVWNVPVDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKASSRETTPGGRKACQLGADRGPHVVLWTLVCLPVVFLLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILCYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDATQEIETSAV", "length": 297, "header": "sp|Q2TBG9-1|TM169_BOVIN Isoform 1 of Transmembrane protein 169 OS=Bos taurus OX=9913 GN=TMEM169 PE=2 SV=1 CANONICAL=Q2TBG9-1" }, "locus": { "chromosome": "2", "start_pos": 104127822, "end_pos": 104125211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013741.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013741.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013741.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013741.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617045", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617045", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZBR0-1", "protein_name": "Transmembrane protein 169", "gene_name": "TMEM169", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSEVLESGSGLEDTVQKESKSGSHSPRHGSVRRAVTTAVTFDGEATMDRRKKKKKESRPESVIVYRSENENKVEEEQADEEGGERSSEEGSKFLGQSVTDGVWNMPSDSRYVTLTGTITRGKKKGQMVDIHVTLTDKELQELAKSKEPPKESVPEKKKCDVGLDRGPHIVLWTIICLPIIFVVSFVVSFYYGTITWYNIFLVYNEERTFWHKITFCPFLIIFYPIIIMVVSFSLGLYSAVTQVSWSFGDWWHAVRDMEKGFCGWLCSKLGLEDCSPYSIVELLDSDNISGSLSGKSSAQGVDTSAV", "length": 307 }, "evidence": [ { "id": "Q2TBG9", "url": "https://omabrowser.org/oma/group/Q2TBG9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H3Z1-1", "protein_name": "Transmembrane protein 169", "gene_name": "Tmem169", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEESAPAESQGQPASPNHGSLRRAVAAALALDGESTMGRRKKKRKESRPESIIIYRSDNEKMDEEPEESEGGDRPKEEEGEDFLDYPIDDGMWNMPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKELSREAAPEGRRVCQVGADQGPHVVLWTLVCLPVVFVLSFVVSFYYGTITWYNIFLVYNEERTFWHKISYCPCLILLYPVLIMAMASSLGLYAAVVQLSWSWGAWWRAACDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDPIQGVETSSV", "length": 297 }, "evidence": [ { "id": "Q2TBG9", "url": "https://omabrowser.org/oma/group/Q2TBG9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BG50-1", "protein_name": "Transmembrane protein 169", "gene_name": "Tmem169", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEESAPVESQGQLPSPHHGSLRRAVAAVLALDGESTLGRRKKRRKDSRPESIIIYRSDNEKTDEEPEESEGGDRPKEEEGEDFLDYPGDDGVWNMPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKELSREAAPEGRRACQVGADQGPHVVLWTLVCLPVVFVLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILFYPVLIMTMASSLGLYAAVAQLSWSWAAWWRAACDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISGNLSNKDPIQEVETSTV", "length": 297 }, "evidence": [ { "id": "Q2TBG9", "url": "https://omabrowser.org/oma/group/Q2TBG9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96HH4-1", "protein_name": "Transmembrane protein 169", "gene_name": "TMEM169", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEPTAVEGQVQLPSPHQGSLRKAVAAALALDGESTMGHRKKKRKESRPESIIIYRSDNEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKESSRETTPEGRMACQMGADRGPHVVLWTLICLPVVFILSFVVSFYYGTITWYNIFLVYNEERTFWHKISYCPCLVLFYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISSTLSNKDPIQEVETSTV", "length": 297 }, "evidence": [ { "id": "Q2TBG9", "url": "https://omabrowser.org/oma/group/Q2TBG9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG9", "url": "https://www.uniprot.org/uniprotkb/Q2TBG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBG9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBG9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBG9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 278, "end_pos": 280 }, { "start_pos": 282, "end_pos": 284 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T003-1", "uniprot_ac": "Q3T003", "uniprot_id": "RL18A_BOVIN", "mass": { "chemical_mass": 20762.0, "monoisotopic_mass": 20762.0 }, "refseq": { "ac": "NP_001028791", "name": "large ribosomal subunit protein eL20", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028791" }, "gene_names": [ { "name": "RPL18A", "type": "recommended", "evidence": [ { "id": "Q3T003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ] }, { "name": "RPL18A", "type": "synonym", "evidence": [ { "id": "NP_001028791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028791" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL20", "type": "recommended", "evidence": [ { "id": "Q3T003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L18a", "type": "synonym", "evidence": [ { "id": "NP_001028791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028791" }, { "id": "Q3T003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL20", "type": "synonym", "evidence": [ { "id": "NP_001028791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028791" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003#function" }, { "database": "UniProtKB", "id": "Q02543", "url": "https://www.uniprot.org/uniprotkb/Q02543#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL18A", "url": "https://www.uniprot.org/uniprotkb/Q3T003", "locus": { "chromosome": "7", "start_pos": 5279457, "end_pos": 5283112, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015831", "url": "https://www.ensembl.org/id/ENSBTAG00000015831" } ] } } ], "crossref": [ { "id": "Q3T003", "url": "https://alphafold.ebi.ac.uk/entry/Q3T003", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015831", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015831", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404142", "url": "https://www.ncbi.nlm.nih.gov/gene/404142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6ZVK", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6ZVK&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "7A01", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=7A01&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR021138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404142", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404142", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIFAKND", "url": "https://omabrowser.org/oma/group/CIFAKND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T003", "url": "https://www.orthodb.org/?gene=Q3T003", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006zvk", "url": "https://www.rcsb.org/structure/pdb_00006zvk", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00007a01", "url": "https://www.rcsb.org/structure/pdb_00007a01", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZVK", "url": "https://www.rcsb.org/structure/6ZVK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7A01", "url": "https://www.rcsb.org/structure/7A01", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001028791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028791", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TN17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1W8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1W8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1W8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1W8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T003-1", "url": "https://www.uniprot.org/uniprotkb/Q3T003-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176, "header": "sp|Q3T003-1|RL18A_BOVIN Isoform 1 of Large ribosomal subunit protein eL20 OS=Bos taurus OX=9913 GN=RPL18A PE=1 SV=1 CANONICAL=Q3T003-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TN17-1", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#A0AAA9TN17-1", "sequence": { "sequence": "KGHSGTWLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 177, "header": "tr|A0AAA9TN17-1|A0AAA9TN17_BOVIN Computationally mapped isoform of 60S ribosomal protein L18a OS=Bos taurus OX=9913 GN=RPL18A PE=3 SV=1 CANONICAL=Q3T003-1" }, "locus": { "chromosome": "7", "start_pos": 5281692, "end_pos": 5279513, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111733.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111733.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098655.1" } ] } }, { "isoform_ac": "A0AAA9TZJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#A0AAA9TZJ4-1", "sequence": { "sequence": "MKASGTLREYKLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 137, "header": "tr|A0AAA9TZJ4-1|A0AAA9TZJ4_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL20 OS=Bos taurus OX=9913 GN=RPL18A PE=3 SV=1 CANONICAL=Q3T003-1" }, "locus": { "chromosome": "7", "start_pos": 5282809, "end_pos": 5279513, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090474.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090474.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102152.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102152.1" } ] } }, { "isoform_ac": "A0AAF6Z1W8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#A0AAF6Z1W8-1", "sequence": { "sequence": "MGLRHLKGGTSGREIKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 186, "header": "tr|A0AAF6Z1W8-1|A0AAF6Z1W8_BOVIN Computationally mapped isoform of 60S ribosomal protein L18a OS=Bos taurus OX=9913 GN=RPL18A PE=3 SV=1 CANONICAL=Q3T003-1" }, "locus": { "chromosome": "7", "start_pos": 5282922, "end_pos": 5279513, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021033.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021033.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021033.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021033.3" } ] } }, { "isoform_ac": "Q3T003-1", "url": "https://www.uniprot.org/uniprotkb/Q3T003/entry#Q3T003-1", "sequence": { "sequence": "MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176, "header": "sp|Q3T003-1|RL18A_BOVIN Isoform 1 of Large ribosomal subunit protein eL20 OS=Bos taurus OX=9913 GN=RPL18A PE=1 SV=1 CANONICAL=Q3T003-1" }, "locus": { "chromosome": "7", "start_pos": 5282809, "end_pos": 5279513, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124180.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124180.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082893.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "site_lbl": "Ser123" }, { "start_pos": 63, "end_pos": 63, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "site_lbl": "Tyr63" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "site_lbl": "Ser71" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404142", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404142", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LQK3-1", "protein_name": "60S ribosomal protein L18a", "gene_name": "Rpl18a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIHIMKVEEIAAGKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P41093-1", "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "RpL18A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRAKGLLKEYEVVGRKLPSEKEPQTPLYKMRIFAPDNIVAKSRFWYFLRQLKKFKKTTGEIVSIKQVYETSPVKIKNFGIWLRYDSRSGTHNMYREYRDLTVGGAVTQCYRDMGARHRARAHSIQIIKVDSIPAAKTRRVHVKQFHDSKIKFPLVQRVHHKGNRKLFSFRKPRTYFQ", "length": 177 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P62717-1", "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "Rpl18a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAAGKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q02543-1", "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "RPL18A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54MK8-1", "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "rpl18a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPIHEFQVVGRHVPTERDANPKIYRMRLFAQTSIHAKSRFWYFLSKIVKMKKSTGEILNVTEIFEDKPQKVKNFGVFIRYNSRSGTHNIYKEYRDLTRCGAVSQMYDEMASRHSARESSIHIIDIKEIAASLTRRANTKQFHDSKIKFPLTHRIAKSKSTFVANRPNTFFC", "length": 171 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7ZWJ4-1", "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "rpl18a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKASGTLREYKVVGRLLPSVKNPAPPLYRMRIFAPNHVVAKSRFWYFVSQLRKMKKASGEIVYCGLVFEKSPLKVKNFGIWLRYDSRSGTHNMYREYRDLTTSGAVTQCYRDMGARHRARAHAIQIMKVQVIAANKCRRPAIKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF", "length": 176 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9LUD4-1", "protein_name": "Large ribosomal subunit protein eL20x", "gene_name": "RPL18AC", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGGFRFHQYQVVGRALPTENDEHPKIYRMKLWGRNEVCAKSKFWYFMRKLKKVKKSNGQMLAINEIFEKNPTTIKNYGIWLRYQSRTGYHNMYKEYRDTTLNGGVEQMYTEMASRHRVRFPCIQIIKTATVPAKLCKREITKQFHNSKIKFPLVFRKVRPPSRKLKTTYKASKPNLFM", "length": 178 }, "evidence": [ { "id": "Q3T003", "url": "https://omabrowser.org/oma/group/Q3T003/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3T003", "url": "https://www.uniprot.org/uniprotkb/Q3T003" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T003-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T003-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T003" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 63, 71, 123 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCI3-1", "uniprot_ac": "Q3ZCI3", "uniprot_id": "PKHJ1_BOVIN", "mass": { "chemical_mass": 17505.0, "monoisotopic_mass": 17505.0 }, "refseq": { "ac": "NP_001029741", "name": "pleckstrin homology domain-containing family J member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741" }, "gene_names": [ { "name": "PLEKHJ1", "type": "recommended", "evidence": [ { "id": "Q3ZCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ] }, { "name": "PLEKHJ1", "type": "synonym", "evidence": [ { "id": "NP_001029741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing family J member 1", "type": "recommended", "evidence": [ { "id": "Q3ZCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3/entry#names_and_taxonomy" } ] }, { "name": "PH domain-containing family J member 1", "type": "synonym", "evidence": [ { "id": "NP_001029741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741" }, { "id": "Q3ZCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3/entry#names_and_taxonomy" } ] }, { "name": "pleckstrin homology domain containing, family J member 1", "type": "synonym", "evidence": [ { "id": "NP_001029741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741" } ] }, { "name": "pleckstrin homology domain-containing family J member 1", "type": "synonym", "evidence": [ { "id": "NP_001029741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHJ1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3", "locus": { "chromosome": "7", "start_pos": 21389365, "end_pos": 21391998, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001647", "url": "https://www.ensembl.org/id/ENSBTAG00000001647" } ] } } ], "crossref": [ { "id": "Q3ZCI3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001647", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001647", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13258", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13258", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529056", "url": "https://www.ncbi.nlm.nih.gov/gene/529056", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529056", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529056", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EEQCKEW", "url": "https://omabrowser.org/oma/group/EEQCKEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCI3", "url": "https://www.orthodb.org/?gene=Q3ZCI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22902:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22902:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029741", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TNY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRYNDKELQALSRQPAEMAAELGMRGPKKGSVVKRRLVKLVVNFLFYFRTDEAEPIGALLLEHCRVIHEEPNSFSISFLEDPERKYHFECCSEEQCQQWMAALRQASYEFMRRSLIFYRNEIQKMTGKDPLEQYGISEEARFQLSGLKA", "length": 149, "header": "sp|Q3ZCI3-1|PKHJ1_BOVIN Isoform 1 of Pleckstrin homology domain-containing family J member 1 OS=Bos taurus OX=9913 GN=PLEKHJ1 PE=2 SV=1 CANONICAL=Q3ZCI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TNY6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3/entry#A0AAA9TNY6-1", "sequence": { "sequence": "MRYNDKELQALSRQPAEMAAELGMRGPKKGSVVKRRLVKLVVNFLFYFRTDEAEPIGALLLEHCRVIHEEPNSFSIIMSSCGGASFSTGMRSRR", "length": 94, "header": "tr|A0AAA9TNY6-1|A0AAA9TNY6_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing J1 OS=Bos taurus OX=9913 GN=PLEKHJ1 PE=4 SV=1 CANONICAL=Q3ZCI3-1" }, "locus": { "chromosome": "7", "start_pos": 21391576, "end_pos": 21390026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119107.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119107.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100281.1" } ] } }, { "isoform_ac": "Q3ZCI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3/entry#Q3ZCI3-1", "sequence": { "sequence": "MRYNDKELQALSRQPAEMAAELGMRGPKKGSVVKRRLVKLVVNFLFYFRTDEAEPIGALLLEHCRVIHEEPNSFSISFLEDPERKYHFECCSEEQCQQWMAALRQASYEFMRRSLIFYRNEIQKMTGKDPLEQYGISEEARFQLSGLKA", "length": 149, "header": "sp|Q3ZCI3-1|PKHJ1_BOVIN Isoform 1 of Pleckstrin homology domain-containing family J member 1 OS=Bos taurus OX=9913 GN=PLEKHJ1 PE=2 SV=1 CANONICAL=Q3ZCI3-1" }, "locus": { "chromosome": "7", "start_pos": 21391576, "end_pos": 21389863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002158.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002158.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002158.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002158.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529056", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529056", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S8I9-1", "protein_name": "Pleckstrin homology domain-containing family J member 1", "gene_name": "PLEKHJ1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRFNEKELQALSRQPAEMAAELGMRGPKKGSVVKRRLVKLVVNFLFYFRTDEAEPVGALLLEHCRVTQEEPSGFSISFLEDPERKYHFECCSEEQCQEWMAALRRASYEFMRRSLVFYRNEIQKVTGKDPLEQFGISEEARFQLSGLKA", "length": 149 }, "evidence": [ { "id": "Q3ZCI3", "url": "https://omabrowser.org/oma/group/Q3ZCI3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5ZLT5-1", "protein_name": "Pleckstrin homology domain-containing family J member 1", "gene_name": "PLEKHJ1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRYNERELLSLSRQPAEKAAEILMRVPKKGSVLKKRLVKLVVNFLFYFRTDEAEPIGALLLEHCRITKEEENVFSISFIEEPERKYCFECDSEEQCQEWIEALKRASYEFMRRSLIFYRNEIQKMTGKDPLEQFGISEEARFQLASHKQ", "length": 149 }, "evidence": [ { "id": "Q3ZCI3", "url": "https://omabrowser.org/oma/group/Q3ZCI3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9D240-1", "protein_name": "Pleckstrin homology domain-containing family J member 1", "gene_name": "Plekhj1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRYNEKELQALSRQPAEMAAELGMRGPKKGSVAKRRLVKLVVNFLFYFRPDEAEPLGALLLERCRVAQEEPGGFSISFVEDLSRKYHFECCSQEQCQDWMEALQRASYEYMRQSLIFYRNEIRKMTGKDPLEQFGISEEARFQLNSLPKDGRTTCIGSQLNVLD", "length": 164 }, "evidence": [ { "id": "Q3ZCI3", "url": "https://omabrowser.org/oma/group/Q3ZCI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NW61-1", "protein_name": "Pleckstrin homology domain-containing family J member 1", "gene_name": "PLEKHJ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRYNEKELQALSRQPAEMAAELGMRGPKKGSVLKRRLVKLVVNFLFYFRTDEAEPVGALLLERCRVVREEPGTFSISFIEDPERKYHFECSSEEQCQEWMEALRRASYEFMRRSLIFYRNEIRKVTGKDPLEQFGISEEARFQLSGLQA", "length": 149 }, "evidence": [ { "id": "Q3ZCI3", "url": "https://omabrowser.org/oma/group/Q3ZCI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" }, { "name": "receptor recycling", "id": "GO:0001881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001881", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 149, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCI3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI3" }, { "id": "PRU00145", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000255", "start_pos": 15, "end_pos": 108, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBN5-1", "uniprot_ac": "Q3ZBN5", "uniprot_id": "ASPN_BOVIN", "mass": { "chemical_mass": 42119.0, "monoisotopic_mass": 42119.0 }, "refseq": { "ac": "NP_001029481", "name": "asporin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029481" }, "gene_names": [ { "name": "ASPN", "type": "recommended", "evidence": [ { "id": "Q3ZBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ] }, { "name": "ASPN", "type": "synonym", "evidence": [ { "id": "NP_001029481", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029481" } ] } ], "protein_names": [ { "name": "Asporin", "type": "recommended", "evidence": [ { "id": "Q3ZBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5/entry#names_and_taxonomy" } ] }, { "name": "asporin precursor", "type": "synonym", "evidence": [ { "id": "NP_001029481", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029481" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASPN", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5", "locus": { "chromosome": "8", "start_pos": 84067214, "end_pos": 84092633, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011847", "url": "https://www.ensembl.org/id/ENSBTAG00000011847" } ] } } ], "crossref": [ { "id": "Q3ZBN5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507990", "url": "https://www.ncbi.nlm.nih.gov/gene/507990", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507990", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507990", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INDFCPT", "url": "https://omabrowser.org/oma/group/INDFCPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBN5", "url": "https://www.orthodb.org/?gene=Q3ZBN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13306", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13306", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029481", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK", "length": 370, "header": "sp|Q3ZBN5-1|ASPN_BOVIN Isoform 1 of Asporin OS=Bos taurus OX=9913 GN=ASPN PE=2 SV=1 CANONICAL=Q3ZBN5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TQ38-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5/entry#A0AAA9TQ38-1", "sequence": { "sequence": "MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVI", "length": 350, "header": "tr|A0AAA9TQ38-1|A0AAA9TQ38_BOVIN Computationally mapped isoform of Asporin OS=Bos taurus OX=9913 GN=ASPN PE=3 SV=1 CANONICAL=Q3ZBN5-1" }, "locus": { "chromosome": "8", "start_pos": 84085649, "end_pos": 84067533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098494.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098494.1" } ] } }, { "isoform_ac": "A0AAA9U1F0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5/entry#A0AAA9U1F0-1", "sequence": { "sequence": "MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKDNLSSF", "length": 233, "header": "tr|A0AAA9U1F0-1|A0AAA9U1F0_BOVIN Computationally mapped isoform of Asporin OS=Bos taurus OX=9913 GN=ASPN PE=4 SV=1 CANONICAL=Q3ZBN5-1" }, "locus": { "chromosome": "8", "start_pos": 84085649, "end_pos": 84068502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102057.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102057.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103030.1" } ] } }, { "isoform_ac": "Q3ZBN5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5/entry#Q3ZBN5-1", "sequence": { "sequence": "MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK", "length": 370, "header": "sp|Q3ZBN5-1|ASPN_BOVIN Isoform 1 of Asporin OS=Bos taurus OX=9913 GN=ASPN PE=2 SV=1 CANONICAL=Q3ZBN5-1" }, "locus": { "chromosome": "8", "start_pos": 84085649, "end_pos": 84068324, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035046.2", "url": "https://www.ensembl.org/id/ENSBTAT00000035046.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000034926.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 272, "start_aa": "Asn", "end_pos": 272, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn272", "evidence": [ { "id": "Q3ZBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (GalNAc...) serine;O-GalNAcylation", "icn3d_view": {}, "start_pos": 45, "start_aa": "Ser", "end_pos": 45, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser45", "evidence": [ { "id": "Q3ZBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507990", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GTA5-1", "protein_name": "Asporin isoform X1", "gene_name": "Aspn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPGWTCTQDSMKEYMMLLLLAVCSAKPFSSPSHTALKNMMLKDMEDMDDDDNDDDNNSLFPTKEPVNPFFPFDLFPTCPFGCQCYSRVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFRGLTSLYALILNNNKLTKIHPKTFLTTKKLKRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDAFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNRITDIENGSFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSITKVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQPATFRCVLGRMSVQLGNVGK", "length": 383 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BT96-1", "protein_name": "Asporin", "gene_name": "BGN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKEYTLLLFLALCSAKPLIGPSYFTLKNMMLQDMEEEDEDDDDDNSLFPTTEPIISLIPFDLFPTCPFGCQCYVRVVHCSDLGLTSIPRNIPPDTRMIDLQNNKIREVKENDLQGLASLYALALNNNKITKIHPKAFQPTKNLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNNDGIEPGAFEGVNIYHIRIAEAKLTSIPKDLPSSLLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLKKVPPGLPDLRYLQVVFLHSNHIAKLGVNDFCPTGRRKKKALYSGISLFNNPVKYWEVQPSTFRCILARNSVQLGNFLK", "length": 371 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SUE4-1", "protein_name": "Asporin", "gene_name": "ASPN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKEYVLLLFLTLCSAKPLFRPSYMTLKNMMLKDMEEEGDDDDDNSLFPTREPINPFFPFDLFPTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKIPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEVQPATFRCVLGRMSVQLGNFRK", "length": 370 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q1LXA7-1", "protein_name": "Asporin", "gene_name": "aspn", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKVLLLLALLTLCNAKPYKHINVMEFMKHHDIMQQDAGDFDDDDDDDDDDDKDYDDYDDNFVTDCPEGCRCSKKVLQCSDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMPENLPISVQSLRLHDNKISRLPKGAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPPGLNTLKYLQVMYLHANSIGYVGVNDFCPSRTRAKKALYTRISLYANPVKYWEIQPPTFRCVSSHNSVQLGNHRK", "length": 370 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99MQ4-1", "protein_name": "Asporin", "gene_name": "Aspn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKEYVMLLLLAVCSAKPFFSPSHTALKNMMLKDMEDTDDDDNDDDDNSLFPTKEPVNPFFPFDLFPTCPFGCQCYSRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSIAKVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQPATFRCVLGRMSVQLGNVGK", "length": 373 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BXN1-1", "protein_name": "Asporin", "gene_name": "ASPN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM", "length": 380 }, "evidence": [ { "id": "Q3ZBN5", "url": "https://omabrowser.org/oma/group/Q3ZBN5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" }, { "name": "bone mineralization", "id": "GO:0030282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030282", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" }, { "name": "negative regulation of tooth mineralization", "id": "GO:0070171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070171", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBN5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBN5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 272 ], "o_linked_sites": [ 45 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0Z3-1", "uniprot_ac": "Q3T0Z3", "uniprot_id": "UBL5_BOVIN", "mass": { "chemical_mass": 8547.0, "monoisotopic_mass": 8547.0 }, "refseq": { "ac": "NP_001032799", "name": "ubiquitin-like protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032799" }, "gene_names": [ { "name": "UBL5", "type": "recommended", "evidence": [ { "id": "Q3T0Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ] }, { "name": "UBL5", "type": "synonym", "evidence": [ { "id": "NP_001032799", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032799" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein 5", "type": "recommended", "evidence": [ { "id": "Q3T0Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-like protein 5", "type": "synonym", "evidence": [ { "id": "NP_001032799", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032799" } ] } ], "function": [ { "annotation": "Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Also plays a protective role against ER stress-induced apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3#function" }, { "database": "UniProtKB", "id": "Q9BZL1", "url": "https://www.uniprot.org/uniprotkb/Q9BZL1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBL5", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3", "locus": { "chromosome": "7", "start_pos": 14422227, "end_pos": 14420689, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049452", "url": "https://www.ensembl.org/id/ENSBTAG00000049452" } ] } } ], "crossref": [ { "id": "Q3T0Z3", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049452", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049452", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614551", "url": "https://www.ncbi.nlm.nih.gov/gene/614551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614551", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GMSLEMQ", "url": "https://omabrowser.org/oma/group/GMSLEMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0Z3", "url": "https://www.orthodb.org/?gene=Q3T0Z3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13042", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13042", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032799", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TSK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Z3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73, "header": "sp|Q3T0Z3-1|UBL5_BOVIN Isoform 1 of Ubiquitin-like protein 5 OS=Bos taurus OX=9913 GN=UBL5 PE=3 SV=1 CANONICAL=Q3T0Z3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TSK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3/entry#A0AAA9TSK8-1", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCTRFLRTMCLWGTMKSTMG", "length": 36, "header": "tr|A0AAA9TSK8-1|A0AAA9TSK8_BOVIN Computationally mapped isoform of Ubiquitin like 5 OS=Bos taurus OX=9913 GN=UBL5 PE=4 SV=1 CANONICAL=Q3T0Z3-1" }, "locus": { "chromosome": "7", "start_pos": 14422095, "end_pos": 14421144, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094293.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094293.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100026.1" } ] } }, { "isoform_ac": "Q3T0Z3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3/entry#Q3T0Z3-1", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73, "header": "sp|Q3T0Z3-1|UBL5_BOVIN Isoform 1 of Ubiquitin-like protein 5 OS=Bos taurus OX=9913 GN=UBL5 PE=3 SV=1 CANONICAL=Q3T0Z3-1" }, "locus": { "chromosome": "7", "start_pos": 14422118, "end_pos": 14421144, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063290.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614551", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614551", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PWV5-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "UBL5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTEDSIRDLKKLIAAQTGTRWDKIVLKKWYTIFKDHVTLGDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JK20-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "Ubl5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B4F450-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "UBL5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6Q546-1", "protein_name": "Ubiquitin-like modifier HUB1", "gene_name": "HUB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MIEVVVNDRLGKKVRVKCLAEDSVGDFKKVLSLQIGTQPNKIVLQKGGSVLKDHISLEDYEVHDQTNLELYYL", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9BZL1-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "UBL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EPV8-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "Ubl5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FGZ9-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "UBL5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIEVVLNDRLGKKVRVKCNDDDTIGDLKKLVAAQTGTRAEKIRIQKWYNIYKDHITLKDYEIHDGMGLELYYN", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V998-1", "protein_name": "Ubiquitin-like protein 5", "gene_name": "ubl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIEITCNDRLGKKVRVKCNPDDTIGDLKKLIAAQTGTKHEKIVLKKWYTIFKDPIRLSDYEIHDGMNLELYYQ", "length": 73 }, "evidence": [ { "id": "Q3T0Z3", "url": "https://omabrowser.org/oma/group/Q3T0Z3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tag activity", "id": "GO:0031386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031386", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z3", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Z3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 73, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Z3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Z3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBB1-1", "uniprot_ac": "Q3ZBB1", "uniprot_id": "SH21A_BOVIN", "mass": { "chemical_mass": 14245.0, "monoisotopic_mass": 14245.0 }, "refseq": { "ac": "NP_001029905", "name": "SH2 domain-containing protein 1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029905" }, "gene_names": [ { "name": "SH2D1A", "type": "recommended", "evidence": [ { "id": "Q3ZBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ] }, { "name": "SH2D1A", "type": "synonym", "evidence": [ { "id": "NP_001029905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029905" } ] } ], "protein_names": [ { "name": "SH2 domain-containing protein 1A", "type": "recommended", "evidence": [ { "id": "Q3ZBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1/entry#names_and_taxonomy" } ] }, { "name": "SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)", "type": "synonym", "evidence": [ { "id": "NP_001029905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029905" } ] }, { "name": "SH2 domain-containing protein 1A", "type": "synonym", "evidence": [ { "id": "NP_001029905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029905" } ] } ], "function": [ { "annotation": "Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1#function" }, { "database": "UniProtKB", "id": "O60880", "url": "https://www.uniprot.org/uniprotkb/O60880#function" }, { "database": "UniProtKB", "id": "B2RZ59", "url": "https://www.uniprot.org/uniprotkb/B2RZ59#function" }, { "database": "UniProtKB", "id": "O88890", "url": "https://www.uniprot.org/uniprotkb/O88890#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH2D1A", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1", "locus": { "chromosome": "X", "start_pos": 8655431, "end_pos": 8469326, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026067", "url": "https://www.ensembl.org/id/ENSBTAG00000026067" } ] } } ], "crossref": [ { "id": "Q3ZBB1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026067", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026067", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613356", "url": "https://www.ncbi.nlm.nih.gov/gene/613356", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613356", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613356", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YSPGRNE", "url": "https://omabrowser.org/oma/group/YSPGRNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBB1", "url": "https://www.orthodb.org/?gene=Q3ZBB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46051:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46051:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46051:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46051:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TTI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR17", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR17-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBB1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKKPSARSTQGATGRRDDPDVFLKTP", "length": 128, "header": "sp|Q3ZBB1-1|SH21A_BOVIN Isoform 1 of SH2 domain-containing protein 1A OS=Bos taurus OX=9913 GN=SH2D1A PE=2 SV=1 CANONICAL=Q3ZBB1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTI5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1/entry#A0AAA9TTI5-1", "sequence": { "sequence": "MDCNLPVRLLCPWDLQARILEWVAMSSSRGSSQPRDQTSVSHISCIGRYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKKPSARSTQGATGRRDDPDVFLKTP", "length": 130, "header": "tr|A0AAA9TTI5-1|A0AAA9TTI5_BOVIN Computationally mapped isoform of SH2 domain containing 1A OS=Bos taurus OX=9913 GN=SH2D1A PE=4 SV=1 CANONICAL=Q3ZBB1-1" }, "locus": { "chromosome": "X", "start_pos": 8655088, "end_pos": 8536131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092471.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092471.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101668.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101668.1" } ] } }, { "isoform_ac": "A0ABI0NR17-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1/entry#A0ABI0NR17-1", "sequence": { "sequence": "MLDTEDRTCACEVAQSCLTLCHLMDCNLPVRLLCPWDLQARILEWVAMSSSRGSSQPRDQTSVSHISCIGRYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKKPSARSTQGATGRRDDPDVFLKTP", "length": 153, "header": "tr|A0ABI0NR17-1|A0ABI0NR17_BOVIN Computationally mapped isoform of SH2 domain containing 1A OS=Bos taurus OX=9913 GN=SH2D1A PE=4 SV=1 CANONICAL=Q3ZBB1-1" }, "locus": { "chromosome": "X", "start_pos": 8655088, "end_pos": 8469352, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151160.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151160.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104926.1" } ] } }, { "isoform_ac": "Q3ZBB1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1/entry#Q3ZBB1-1", "sequence": { "sequence": "MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKKPSARSTQGATGRRDDPDVFLKTP", "length": 128, "header": "sp|Q3ZBB1-1|SH21A_BOVIN Isoform 1 of SH2 domain-containing protein 1A OS=Bos taurus OX=9913 GN=SH2D1A PE=2 SV=1 CANONICAL=Q3ZBB1-1" }, "locus": { "chromosome": "X", "start_pos": 8655088, "end_pos": 8635193, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104449.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104449.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613356", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613356", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W811-1", "protein_name": "SH2 domain-containing protein 1A", "gene_name": "SH2D1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGATGRREDPDVFLKTP", "length": 128 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LVA5-1", "protein_name": "SH2 domain-containing protein 1A", "gene_name": "Sh2d1a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKIKNLISAFQKPDQGIVIPLQYPVEKSSARSTQGTTGRSDSDVCLKAP", "length": 126 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BV81-1", "protein_name": "SH2 domain containing 1A", "gene_name": "SH2D1A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEALPIYHGGITREAGEKLLLAAGADGSYLLRDSESIPGVYCLCVLHQGYVYTYRVSKTESGSWSAETAPGVHRRLFRKMHNLISAFQKPDQGIVTPLKHPVINCAKAKYSPGRSDGRDYLQPS", "length": 124 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F0N7-1", "protein_name": "SH2 domain-containing protein 1A", "gene_name": "sh2d1ab", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESLSVYHGAISREMCEMRLNEAGKDGSYLIRDSESVAGAYCLCVLCKGFVYTYRLQKDSAGSWAAETAPGQTKRLFRKVKNLISAFEKPGQGIAIPLLYPVTIQKSY", "length": 108 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O60880-1", "protein_name": "SH2 domain-containing protein 1A", "gene_name": "SH2D1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP", "length": 128 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88890-1", "protein_name": "SH2 domain-containing protein 1A", "gene_name": "Sh2d1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP", "length": 126 }, "evidence": [ { "id": "Q3ZBB1", "url": "https://omabrowser.org/oma/group/Q3ZBB1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" }, { "name": "cellular defense response", "id": "GO:0006968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006968", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBB1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBB1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBB1" }, { "id": "PRU00191", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000255", "start_pos": 6, "end_pos": 102, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDJ5-1", "uniprot_ac": "Q2YDJ5", "uniprot_id": "CX066_BOVIN", "mass": { "chemical_mass": 40637.0, "monoisotopic_mass": 40637.0 }, "refseq": { "ac": "NP_001193729", "name": "uncharacterized protein CXorf66 homolog precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729" }, "gene_names": [ { "name": "LOC112445184", "type": "recommended", "evidence": [ { "id": "Q2YDJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5" } ] }, { "name": "CXHXorf66", "type": "synonym", "evidence": [ { "id": "NP_001193729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729" } ] } ], "protein_names": [ { "name": "Uncharacterized protein CXorf66 homolog", "type": "recommended", "evidence": [ { "id": "Q2YDJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5/entry#names_and_taxonomy" } ] }, { "name": "CXorf66-like", "type": "synonym", "evidence": [ { "id": "NP_001193729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729" } ] }, { "name": "uncharacterized protein CXorf66 homolog precursor", "type": "synonym", "evidence": [ { "id": "NP_001193729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729" } ] }, { "name": "uncharacterized protein CXorf66 homolog", "type": "synonym", "evidence": [ { "id": "NP_001193729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ5", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5", "locus": {} } ], "crossref": [ { "id": "Q2YDJ5", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049080", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767881", "url": "https://www.ncbi.nlm.nih.gov/gene/767881", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767881", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767881", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KYYSEVD", "url": "https://omabrowser.org/oma/group/KYYSEVD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDJ5", "url": "https://www.orthodb.org/?gene=Q2YDJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37340:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37340:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27959", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27959", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193729", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ5", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIVIGTLITGYMVSCTCLLHYSCDSEEAHTAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKPVSQVSPSYPEKAIKSTWPPSLQCRAKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSRNN", "length": 361, "header": "sp|Q2YDJ5-1|CX066_BOVIN Isoform 1 of Uncharacterized protein CXorf66 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=Q2YDJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5/entry#A0AAA9TUZ2-1", "sequence": { "sequence": "NESNGSATLTTHAEFKQTKLQELRRRLLIIVIGTLITGYMVSCTCLLHYSCDSEEAHTAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKPVSQVSPSYPEKAIKSTWPPSLQCRAKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSRNN", "length": 340, "header": "tr|A0AAA9TUZ2-1|A0AAA9TUZ2_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC112445184 PE=4 SV=1 CANONICAL=Q2YDJ5-1" }, "locus": { "chromosome": "X", "start_pos": 23632517, "end_pos": 23629624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123397.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123397.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100403.1" } ] } }, { "isoform_ac": "Q2YDJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5/entry#Q2YDJ5-1", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIVIGTLITGYMVSCTCLLHYSCDSEEAHTAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKPVSQVSPSYPEKAIKSTWPPSLQCRAKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSRNN", "length": 361, "header": "sp|Q2YDJ5-1|CX066_BOVIN Isoform 1 of Uncharacterized protein CXorf66 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=Q2YDJ5-1" }, "locus": { "chromosome": "NKLS02002208.1", "start_pos": 4886423, "end_pos": 4883477, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079795.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079795.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069066.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 24, "start_aa": "Asn", "end_pos": 24, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn24", "evidence": [ { "id": "Q2YDJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767881", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767881", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A075B5S0-1", "protein_name": "Immunoglobulin heavy variable 16-1", "gene_name": "Ighv16-1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "EVQLVESGGSLGQPGGSTKLSCEEASGFTFSDHWMDWFRQAPGMRLEWLANTNHDESGKGYAESVKDRFSISRDNSENLLYLQMNSLRNEDTALYYCAR", "length": 99 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B603-1", "protein_name": "T cell receptor alpha variable 6D-6", "gene_name": "Trav6-6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSSPGFVAVILLILGRTHGDSVTQTEGPVTVSESESLIINCTYSATSIAYPNLFWYVRYPGEGLQLLLKVITAGQKGSSRGFEATYNKETTSFHLQKASVQESDSAVYYCALG", "length": 114 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B625-1", "protein_name": "T cell receptor alpha variable 4N-3", "gene_name": "Trav4n-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERNLGAVLGILWVQICWVSGDKVKQSPSALSLQEGTNSALRCNFSIAATTVQWFLQNPRGSLMNLFYLVPGTKENGRLKSAFDSKESYSTLHIRDAQLEDSGTYFCAAE", "length": 110 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B695-1", "protein_name": "T cell receptor alpha variable 9D-3", "gene_name": "Trav9d-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLALLPVLGIHFLLRDAQAQSVTQPDARVTVSEGASLQLRCKYSYFGTPYLFWYVQYPRQGLQLLLKYYPGDPVVQGVNGFEAEFSKSNSSFHLRKASVHWSDWAVYFCAVS", "length": 113 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B6B4-1", "protein_name": "T cell receptor alpha variable 6-4", "gene_name": "Trav6-4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNTSPVLVTVMLLFMLGMRKTHGDSVTQKQGQVTLSEDDFLFINCTYSTTTYPTLLWYVQYLGQGPQLLLKVTTANNKGISRGFEATYDKGTTSFHLQKASVQESDSAVYFCALV", "length": 115 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B6D8-1", "protein_name": "T cell receptor alpha variable 3-3", "gene_name": "Trav3-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "GEQVEQRPPHLSVREGDSAVITCTYTDPNSYYFFWYKQEPGASLQLLMKVFSSTEINEGQGFTVLLNKKDKRLSLNLTAAHPGDSAAYFCAV", "length": 92 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B759-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4E", "gene_name": "PPIAL4E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A075B767-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4H", "gene_name": "PPIAL4H", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFDITVDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTDDKSIYGEKFDDENLIRKHTGSGILSMVNAGPNTNGSQLFICTAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087WP50-1", "protein_name": "Secretoglobin, family 1B, member 15", "gene_name": "Scgb1b17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMLAGAVVIFGVALLLLSSWGDCGICPAMKEDVHLFLNGTSEEYVEYVKQYKDDPEILENTEKIKQCVDSTLMEEDKAHANGFIEKIEASPLC", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPA9-1", "protein_name": "Secretoglobin, family 2B, member 18", "gene_name": "Scgb2b18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTSEACVSFFEGYASVLSGSRVWLYQELQAFDATAEEKVALEKIQSCYSEERIRNILLEPKIMEAMVASPECRSYHSFNNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPG5-1", "protein_name": "Predicted gene 13283", "gene_name": "Gm13283", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVHLFLVGGVMLSCSPASSLDSGKSGSLHLERSETARFLADLRSVPGHQCLRDRTDFPCPWKEGTNITQMTLGETTSCYSQSLRQVLHRFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSCPLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQLQVDLPAFPLSARRGPR", "length": 182 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPY7-1", "protein_name": "RNA binding motif protein Y-linked family member 4", "gene_name": "Rbmyf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETNQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRLADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDDPPSKR", "length": 166 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQA9-1", "protein_name": "Secretoglobin, family 2B, member 21", "gene_name": "Scgb2b21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACVPFFEGYASVVSGSRVWMYQEFQAFDATAEEKVALEKIQGCYREESLRNILLEPKIMEAMVASPECLSYYSSNNIRCILDLLSKLLGQ", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQJ0-1", "protein_name": "Secretoglobin, family 1B, member 11", "gene_name": "Scgb1b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLVAAVVILGAALLLLTSGGDCGICPAIKEDVRLFLNGTSEEYVEYVKQYKDDPVILENTAKINQCVDSTLTEKDMTHTTTFLKKIEDSLLC", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQP8-1", "protein_name": "Predicted gene, 21698", "gene_name": "Gm21698", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHGQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTKGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR36-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r90", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSQNEAMKTTEEVALQIVLLCQFGIGTMANILLFIHNFSPLLTGCQLRPKQVICTNMAVSSILILFMTVFPNNVFVVQRNLMNDLQCKLEYFLRMVARSINLCSTCVLSTYQFVTLLPGNFGEMMVRGRRSKVISYSCCSCWLFGVLYNVYIPMKVSGPQNTHNKTDIKSKWFCVTSGFSVGIMFLWFAHDAIFISIMIWTSVSMVLLLYRHYQRLQYIFPPHQGTRGYAEIRAAHSIAMLVVTFVSFYLLHCICFILHIVFVDSRLWLRHVGEVLTSSFPTISPLLLIFRDPSYPCSLIFNYRKPVI", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR44-1", "protein_name": "BTB domain containing 35, family member 15", "gene_name": "Btbd35f15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIHALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR49-1", "protein_name": "Secretoglobin, family 2B, member 11", "gene_name": "Scgb2b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTSEACVSFFEGYASVLSGSRVWLYQELQAFDATAEEKVALEKIQGCYSEERIRNILLEPKIMEAMVASPECRSYHSLNNFRSILEFISNLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WSM5-1", "protein_name": "Predicted gene 29049", "gene_name": "Gm29049", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSLKKKSRRKPSSQALGNIVGCRISYGWKEGNEPVTHWKAIILGQLPTNPSLYLVKYDGIDSVYGQELHSDERILNLKVLPHKVVFLQVRDVHLASALVCREVQHKFEGKDGSEDNWSGMVLAQVPFLQDYFYISYKKDPVLYVYQLLDDYKEGNLHIIPETPLAEARSGDDNDFLIGSWVQYTRDDGSKKFGKVVYKVLANSTVYCIKFLGDLHIYVYTLVSNIT", "length": 227 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WSN2-1", "protein_name": "BTB domain containing 35, family member 16", "gene_name": "Btbd35f16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLLFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLNFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WUL8-1", "protein_name": "NBPF family member NBPF19", "gene_name": "NBPF19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLFHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYLDNRFFTLTVTSLHLVFQMLVIFPQ", "length": 3843 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087WXS9-1", "protein_name": "TBC1 domain family member 3I", "gene_name": "TBC1D3I", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKMKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087X179-1", "protein_name": "TBC1 domain family member 3E", "gene_name": "TBC1D3E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDQAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0A0MQP3-1", "protein_name": "BTB domain containing 35, family member 12", "gene_name": "Btbd35f12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDSDLSITPLEVPQGLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YW58-1", "protein_name": "Immunoglobulin heavy variable V8-2", "gene_name": "Ighv8-2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRLTFSFLLLLPVPAYVLSQVTLKVSGPGILQPSQTLSLACTFSGISLSTSGMGLSWLRKPSGKALEWLASIWNNDNYYNPSLKSRLTISKETSNYQVFLKLTSVDTADSATYYGAWR", "length": 119 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YXW2-1", "protein_name": "Predicted gene, 20773", "gene_name": "Gm20773", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVGCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKIFKVEKS", "length": 232 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YXX7-1", "protein_name": "Predicted gene, 20807", "gene_name": "Gm20807", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVGCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHTFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKVLEVEKS", "length": 232 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0B4J1J8-1", "protein_name": "T cell receptor gamma, variable 4", "gene_name": "Trgv4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNPGSQALLPLYLPWEANLADENPLLKVVIFLCLLTFGHGKLEQPEISISRPRDETAQISCKVFIESFRSVTIHWYRQKPNQGLEFLLYVLATPTHIFLDKEYKKMEASKNPSASTSILTIYSLEEEDEAIYYCSYG", "length": 138 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JE01-1", "protein_name": "Predicted gene, 21663", "gene_name": "Gm21663", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADPPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JGR8-1", "protein_name": "Predicted gene, 21680", "gene_name": "Gm21680", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRETREGRKDADLPSESNEGRRRWTWRMWMAHRQTTSPVPVTSKKQFEKEEKELIKKIQLTTKEINELRDRLIYVTKGSMNKRPYHRQTRHYKELKLKEKEIMTYLHELEMKNMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLVILQQESKEVHADWATIHQSLVELNLSGKDEQEKTSNLETQEHQVSEAARELVLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JMD5-1", "protein_name": "PRAME family member 33", "gene_name": "PRAMEF33", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQAPSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLRLPLGSLMKTPHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLQDVDENFWTIWSGARVLSCSPEAMSKRQTVEDCPRMGEHQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHLCCSKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCSLNKTGKFAPYLSQMSNLRELFLAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKISNIKEHLEHLLRYLKNPLGAFIFSDAYLADRDMECLSQYPSLSQLKELRLIHILMWTTNLQPLGALLEKVAATLKTLVLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTRGLSKLGLELYPAPLESLDYKGHVNWEILTPIRAELMRTLREVRQPKRIFFGPVPCPTCGSWPSEKVDFHLCS", "length": 474 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0G2JNH3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC124905359", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKIANNTVVTEFILLGLTQSQDIQLLVFVLILIFYLIILPGNFLIIFTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFFSEKKVISYRGCITQLFFLHFLGGGEGLLLVVMAFDRYIAICRPLHCSTVMNPRACYAMMLALWLGGFVHSIIQVVLILRLPFCGPNQLDNFFCDVRQVIKLACTDMFVVELLMVFNSGLMTLLCFLGLLASYAVILCHVRRAASEGKNKAMSMCTTRVIIILLMFGPAIFIYMCPFRALPADKMVSLFHTVIFPLMNPMIYTLRNQEVKTSMKRLLSRHVVCQVDFIIRN", "length": 316 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0G2JTV6-1", "protein_name": "RIKEN cDNA 4931429L15 gene like", "gene_name": "4931429L15Rikl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQFNPFSQDTWRHGHRRAYSNISERLSCLTLQEPSVSHLYQIFSPGDRRSYLLDDSLSNSIQRESLAVPMGLEDSGSRGQQKQQQPGAVLEDLEEQEIAPTDVKYRLQLLDEAPLRSKSSSVQSQGHKPGWIPSSKTHREWFKPWKMDMTYPENERSHSGHTQGRRMTPRAQWRHVEYDSQDQDTQSPVWSQALFPGLDKSSQGVIQCTQHVSREREMVSGWSMTHAPQEMGQAKQGPAFLKTKGTAKFNVATTARMSCLPPLKLLEKKVKSRCPPNTPGIFQDWRAQPQGLYGSDERLLAPFEDQVNTRVTYMPLFTEKVKFVSPKTAVSNPKQTHSQLSRTNQPAFPGQFRNWTSGREHLEKGLPE", "length": 368 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JVP7-1", "protein_name": "40S ribosomal protein S26", "gene_name": "Rps26-ps4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKKRRNNGRTKKGRGHVQPIGCANCSWCVPKDKAIKKFVIWNIVETAAVRDISEARIFDAYVLPKLYVKLHYCVSLAIHSKVIRNQSHEARKDRTSPPRFRPAGAAPRPPPKPM", "length": 115 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JW93-1", "protein_name": "High mobility group protein B4", "gene_name": "Hmgb4l4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKDSKVRPKVNVSPYVHFMMDFRNQTREQQPNTYYDFTEFSRKCSEKWKTISKKEKKKYEALAKRDKDRYQREMRNYSGPRRERRRRDPDAPRKPPSSFLLFSQDHFDEIKEQHPNWTVAQVAKAAGRMWARCSEADKIPYEERAAVLRAKYLEEREAYYHQCQRGE", "length": 168 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JW96-1", "protein_name": "Zinc finger protein 94 like 1", "gene_name": "Zfp94l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPRGSCDVMLESLRNVASLGHRIGTPDGLLRLKREDMFWLLTVARWSSGSMGDKNLEDMEFLEEVGLRHLPHEELFCSQIWQRITRELTKVRDCRVRVGENGSPMKRDNREDEYSKHSSQNSVFQVHHRECHEEEANERDFGCSHHLRTSTGEKSYKCEKCHNASHWFSSLQSHQGVCDRPRWNKSVSQFKIFRQWPLFHYQQSMPNGENAQEYEACGNAGKNSSGQTALFVHTAEEPYSCEECGARFSQSSYLQVHQRVHTGEKPYKCEECGKGFGWLSQLHAHHQSHTGEKPYTCDACGKGFSYSSHLNIHCRIHTGEKPYQCEECGKGFSQASNLLAHQRGHTGEKPYQCDACGKGFSRISDFNIHIRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCNTCGKSFRRSSDLNVHCRIHTGEKPYRCEKCDKVFSQFSSLQVHQRVHTGEKPYQCSECGKGFSVGSQLQAHQRCHTGERPYQCEECGKGFCRASNFLAHHGVHTGEKPYRCDMCGKHFRQRSYLQAHHRVHTGEKQFRCEECGKGFSWSSYLQAHQRVHMGEKPYKCEECGKGFSWSSSLLTHQRVHAEDEGQKDLSSSGGSYRK", "length": 616 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JYP5-1", "protein_name": "Olfactory receptor", "gene_name": "Or8g52b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEGNHSRVTEFILTGLTDKPELQLPLFLLFLGIYLLTVLGNLGMIILILLSSHLQTPMYFFLSGLSFIDLGYSTVIIPKMLVNFVTEKNVISYPGCMTQLYCFIAFVLCECYMLSAMAFDRYVAICNPLRYNVTMSYQVCFWMIGGVYSIGFIEATIHTVCMLQVFFCKANVVNHFFCDLLPLFQLACSSTFVNETVLLCLSTLNFCVPTLTILSSYSFIIARIIRIKSTESRFKAFSTCSSHFSSVAVFFGSLGFVYFQPSSVSSKDQGKVSSVFYTIIVPMLNPLIYSLRNKDVKLALNKLFQKKIFHM", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K381-1", "protein_name": "Killer cell lectin-like receptor, subfamily A, member 4", "gene_name": "Klra4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEQEVTYSTLRFHNSSGLQNQVKTNETQGPRETGHRGCSVSWHLIMIPLGILCSILLVTVAVLVTHIFQYSQEKHELQEALNKLHHNYSTMQNESYLNEEMLGNKSSECDAYKSVLDSLNRQQNTCLRLTNIVLDCLQHKGRQVNVHLFCCGIKCYYFIMDKKQWKECEQACQGCKLSLLTIDDEDELKFLQLQVTPDSYWIGLSYDNKKHDSAWIDNNPSKL", "length": 224 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K3S0-1", "protein_name": "Olfactory receptor", "gene_name": "Or4c109", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNQSFVNEFILLGLSQNPQIKKISFVIFLLVYIATLVGNMMIVVTIAYSPALLGSPMYFFLAVLSFLDACVSSVVTPKMIVDMVYERKSISFECCMTQVFAVHFLTAVEVIVLAAMAYDRYVAICKPLHYSSIMNRRLCGTLVGVAWAGGFLHSIIQIAFTLPLPFCGPNVIDHFICDLFPLLKLACTDTHIFIILVFANSGSICIIIFSFLLISYGVILFALRAHSSEGRRKALSTCGSHITVVVFFFVPCILIYARPTSAFSFEKNVFVFTDVLTPLLNPMVYTFRNKEMINAIRKMWKRLIVVSDKY", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K622-1", "protein_name": "Histone RNA hairpin-binding protein", "gene_name": "Slbpl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSSRMEMVSVGVTTEPCHARWEVETDEVVLRRRQKQIDYGKCTPGYQSFLQQVPRAQRQPGFHPQTPNKNRRYSRRSWDAQIRQWRRALHTWDPPSQPLHDRQAEGKAAGNFLRPVDTAPLDDLLDNWPQDPESSENWDRGEKEAQFAYLKVPASCPPQLKDELLHH", "length": 169 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K698-1", "protein_name": "Lamin tail domain containing 1", "gene_name": "Lmntd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHLASSHRVQKSSLARPERRAKSPSYTDISFWVPVMHRVGSQYQFESVCEQSSGYPGMPAQQVTPVPSQRGGILRKEEKTGTITPSKQHSSVHFFPKVMDSSSTLHLLSGSFSHEASANFHQIPSAQDSLSPGGLLTSKSNVPSCSRKDSIPGKQSTHQAASPGTSLMTLKKQPKPSSDLDTYVLGDGEDYFLSLFGDSKKLTSHTSQAEDVSKHLSVILEEVGQFVSSSLGDIKIAEVNVKGFFVRLVNSSNEKEVEIGNYILQQNVNGQAVSLYRFPHNITMQASGTVTVWAAASEAKPQQPTDFVWEEQSRFRSSPDCTTILCKPSGEAIAWYTPIHWKQAWEKLETDIEFERCSVVIPSLKSHIFGRTTSSVSSINKEKQEPTQKTPPQVCSVLLREKEILLTVLPNKSPWCRSPDTPPHPYSSLIEWHDSDFPGSSLGTQPKPQSTKPKPDPGTKEKKSTR", "length": 467 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K6E6-1", "protein_name": "Rho GTPase-activating protein 20-like", "gene_name": "LOC120093152", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIHRTLLCQGPVELTSGRKRNKRYLSLFDDVLVVSTNLTKKKFKIKCIIPLNYLWVVDDEELVRANKTCTCKTIFFYWATGNALATFRSEEQKVQWYTFLTSRSISEAKKGIKKTFPLHIFPEDIQTCDSSLCVTATNMDTVNDIMEKLLPMIRVHKIEDYQLWFSPGHKEAPRALQGHEYPYDIIMNNVQNNLSKSNSKIFTAFPPLPGLFMENQSWDTGGQFILKPRDSAGSQQQDAKERRRKSCMTSCFHGGCVPHHDQECSDPRDDKRGKLFGQDLSSICQDGKLPTIILDMLSRIKDKGPTTDDIFLITPNGSLCKTIKEKLDNGENVDIYQQPVHVVAWILKEFLQSIKGSLLTSKLYDQWLIVPEKVNDKEKLAAVKSLLEKLPKPNADLLRQLFRILHQIKTKSSVNNMSSFRLSLETAPCILWLPSYRNNILTNDIAKKISLVTFMIDNSPELFGEDIVAVWYETSLYHPPGLKYPCSQNTPSSNGIMEETEHGLSSCPGERTCTPDFDELPRSGAVASIPYEGILASEKGEGNESTTQPEPVQNSPTPQTKKELGNCSPNILKDVNVPAVILDMLSVIAEKGQCSDDIFRMQAEKSHWSLKEKVNTGKHVNLKEESVLTVASVVKDFIKNIEGSLLSCDLYENWLSIPDEGPLLGKIASIQNILLKMPKPNYVLLKQLICVLQKIKAASTNQLDTFDLSVRIAPHVLWNPTCKMFYGRDLSKKLSIIQFMIDNCQELFGENDNIFCEDNQKSYDINLSSDTLNTSGKATLMIETIDDHDVKTSKANTKELEMSSAVPHEGGPTAGHNGTTSKYNVPQEIILHD", "length": 835 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K6V9-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Smokwl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDITSIKKTLGSQYRVVFFLGQGSYGRVRLAWHRRTQALVAIKTVEISKDTIRGILSEMTTLESLNHPNIISLYEVLITGTGVHFILQYAPGGNLGKLISEEGPLPEEKAKKMFGQVVSAIRYCHSLDIVHRDIKPQNILIDGEGNIKLIDFGQAIKCKPGTLLSRHCGTRDFNAPELVLREPYDGKSSDVWSLGVVLYFFTTGYLPFRGKTINDVEERITTGTYTIPTHLSGQLENLIHQILRVSPDMRPSVEEIENHPWIKKCEFKILPKTDPDYKIIEMLCAMGYKAKDILESLQKKRYDEPMGAYLSLKDHVSKGFDVGYITPAKPGDPCPPPPPSPAHPSVFGLPLRRRASEPIFGLHHRPPSREQNPLDLILSGLKMSRCVSMPPIAVYYPKKERSTSTRALHSTPVACPCVSNNMSEVEIILPPKQDIEMNTSSPPQRMGWFKRLRKGIRDCFSRLCCLPRAPKKKTQHRSSKRVAPLKKAASSTI", "length": 493 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K894-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHLLNVTEFIFLGLSPNKEGQRVCFVLFLLLYMAIVLGNLLMVVTVAASRNLGSPMYFFLSFLSFVEICYSSTTAPKLIFDLLAEKKSISVWGCMTQLFFMHFFGGTEIFLLTMMAYDRYVAICKPLHYTSIMNQQVCAVLVGSAWIGGFVHSFSQILLILPLSFCGPNVIDHYFCDLLPVLKLACSDTFLIGLLIVVNGGTLSVISFVVLLASYLVILFHLRTQSAEGRRKALSTCGSHVTVVILFFGPCVFIYSRPSDTLPVDKMIAVFYTVITPLLNPLIYSLRNAEVKKAMKNLWFRIMKADEK", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KB39-1", "protein_name": "Myb/SANT DNA binding domain containing 5 like 1", "gene_name": "Msantd5l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQREANQGESLENTEESNVGKSVKEEEQRPSGRSRSSWTDSEIRVFLQEWEVVEQEMGQPGRKLHKKTKSLCQRLYQQGLKKSWKSCFHLLLSLQDLHRTLCNERPGIEPLFSPYSEALYRILGSTPHESWFPGPLYDEADDSMLPVYPQPPMYQPSDYGITVPSAQLQGNPVPMMCQEDSPFPTWEPWNPSYPLSVPHLLPGFAPGDPSLQQPWSMCDLHQDPQ", "length": 225 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KBC9-1", "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3-like", "gene_name": "Lilrb3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTFTFTALLCLGLTLRLWIPVLTGSLPKPILRVQPDSVVSMGTKVTFVCEETIGVKESHLYRNGNLQRTVLKNHQKPTNKTEFSFSNVDQQMQQYQCSYRTQTKSSDYSEPLELVVTGAYSKPSLSAQTNPVVTSGGYVTLKCEPSQDNHTLILTVEGSQKHSWRKDPECNRYTEKCHALFYVGPLTSNQRWIFRCYSYEKHTPQVWSAPSEPVELLVSGKLQKTTIKAEPGSVIRSGRAMTIWCQGDLDAEIYFLHKEGSHNTQSTQTLQQPGNKAKFLIPSVTQRHAGQYRCYCYSSAGWSEPSDTLELVVTGIYYYGVKLSGLPSPVVPEGGNVTLHCTSHSNYDKFILTKEDQKFTSSLDAEYIPSTGQHQALFVMGPMTPNYSGTFRCYGYYKHTPQLWSVPSELLKIFISGPSRKPSLLSHQGHILEPGMSLTLQCYSDTKYDKFALYKEGGTDIIESFSQWTKAGLSMTNFTLSVMPNSTVHSGENVTLMCWSTYSVDTFILSKEGSGQPPLRLKSKIQDQQYQSEFSMSGVTSKLSGTYRCYGSHDSSLYLKALIGVSVAFLLFLFILIFILLRRRHQEKFRKDDEDAQKGKELQLSTGAAEPVTRDRGHQKRSNPAAATQEESLYASVEDMETKDGVELDTWKPPEGDPQGETYAQVEPSRLRRAGAISPVVSREQLNTKYEQAEEGQEVDSQATESEEPQDVTYAQLCSRTLRQGTAAPPLSQAGEAPEEPSVYAALATARPGAVPKNKKQ", "length": 761 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KIH5-1", "protein_name": "Major histocompatibility complex class I LLA precursor", "gene_name": "mhc1lla", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTGKVLFVLFLLSAPTTVLTDSHSLWLLGTYIKGETQFPKLSFTVMLDDLRVGFYNSETKEFIPRDNTTNEDEAVSDVLTVIQNTLEPFMMSTLTFKNGTESPQLFQITWHCELLDNDKPGQIIFKIAFSGSTTDEVSFYNDNFTCQCQNNMATVPLESFQMHYETVCYPNCIATIRDYLKKRQTQVNGKVQPKVRLIKKVHPKSGGFRLSCLATEFYPHSINLTLLRDGQPVSDHEVTGGNLLPNGDGTYQMRKSLEIRADEREKHKYTCSVSHLSLDKILDIDFEFDPSFLIKIVIPVVVLLSLMLVLTAVLIHKCKNKRAESKETITTASTPEPTEMSETLRK", "length": 346 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IEQ0-1", "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gna11a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTLESMMACCMSEEAKESKRINAEIDKQLRRDKRDARRELKLLLLGESGKSTFIKQMRIIHGTGYTDEDKRGYTKLVYQNIFTSMQAMIRATEHLKIPFRFEDNKKNALLVREVDVEKVCSFEQPYVAAINKLWMDPGIQEAYDRRREYQLSDSTKYYLNDLERISSRGYMPTQQDVLRVRVPTTGIIEYPFDLENIIFSYLSDLERISDPSYLPTQQDVLRVRIPTTGIIEYPFDLQSIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKILCSHLVDYFPEFDGPQNDAQSAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQHNLKEYNLV", "length": 400 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4ILG2-1", "protein_name": "FXYD domain-containing ion transport regulator", "gene_name": "fxyd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVESPEHSDADFTYDYELIRRGGLIFAAVLFCLGMVIIFSKKLRCGKSSATHEDNGDL", "length": 59 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IU63-1", "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "grm1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRMLILRMNFFIVFLLFCTRLHLSTERSAVSRAASRSVARMDGDIIIGALFSVHHQPSAEKVAERKCGEIREQYGIQRVEAMFYTLDRINSDPYLLPNITLGCEIRDSCWHSSVALEQSIEFIRDSLISIRDEREGPKWCVEGNPSAQPPATKKPIAGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARALLDIVKRYNWTYVSAVHTEGNYGESGMEAFKELASQEGLCIAHSDKIYSNAGEKHFDRLLRKLRERLPKARVVVCFCEGMTVRGLLMAMRRLGVAGEFLLIGSDGWADRDEVVEGYEEEAVGGITVKLQTEEVTSFNDYFLKLRLATNNRNPWFAEFWQHRFQCRLAGHPQENTNYRKNCSGYESLEDNYVQDSKMGFVINAIYAMAHGLHDMHEHLCPGHVGLCEEMDPIDGSKLLDFLLKTSFAGVSGEDVWFDENGDSPGRYDIMNLQYVEPGVFDYINVGSWHEGILSIDDYMIQMNRSEMVRSVCSEPCSKGEIKVIRKGEVSCCWICTPCKDNEYVQDEFTCKACELGWWPDEELQVCEPLPLRYLEWSHPESIAAVVFSCLGILVTSFVTLVFILYRDTPVVKSSSRELCYIILAGIFLGYICPFTLIARPSIASCYLQRLLVGLSASMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIAFILISMQLTLEVTLIILEPPEPIKSYPSIREVFLICNTSNMGMVAPLGYNGLLILSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTSFSVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKIACRSNSLLNMFKRKKNASGNANSNGKSVSWSEPGSRHPPKGEHMWHRLSVHVKKQEAGSNQTAIIKPLTNTYNNPGMEFSDLSTKTLYNVAEEDEIDPIRYNPSNSPHLMAPVSKPMKEVGANLTFYTPEQHVPQQNSVLPQHAMIEHFQDDVVKYNSNMADLDEIISLPEPTDGIILALQPQVLHPHPILPMNVYQDEPSSPLEEVENEQFGLLHGYMYDNAQIHDEEELVQIKMAMEDSMALMPPSPFRDSLGSGSPVRNSPVSESVLCTPPSVTYASVILRDYKQSSSTL", "length": 1158 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IUN8-1", "protein_name": "Trypsin inhibitor ClTI-1-like precursor", "gene_name": "spink2.9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLAQIVLLLCLSVMATAADKCPSVPNCSRYHPHACTMEYWPVCGSDGNTYGNECELCATIFEEKLNIILISKKGEC", "length": 76 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4J2B9-1", "protein_name": "BTB domain containing 35, family member 23", "gene_name": "Btbd35f23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEGIAGASYIPVSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFTNILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQKCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICNLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNQEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A140T8Q5-1", "protein_name": "BTB domain containing 35, family member 21", "gene_name": "Btbd35f21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDMKLMYLLALSSDLLVMQKEIDVYTTLKIWMILYLNPCWNGTMKQLLQHANNWLSTHMAYIDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GQX3-1", "protein_name": "Cortexin domain containing 2", "gene_name": "Ctxnd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCVLMEDSSMSNGIDVDKGFAIAFVVLVFVFLIVMVFRCVKLVKNPYEVSSTTADLPLN", "length": 59 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GRH6-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 3", "gene_name": "Zscan4-ps3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQYATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIIQKEQHPEHEEGNVVRQFPHGARRASQGTPSHHVDIQSPPTTADVTMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGFPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCKSHQKRFCRDAKLYKCEECSRMFKHARSLSSHQKTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GS00-1", "protein_name": "Predicted gene, 36210", "gene_name": "Gm36210", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHPGSPAAPGVSEPGPRELCAFVSGASAHMLRALQPRRIRPSKRRPNHRRFLHNQICREFAKIEAATQHLALTILSQKAPAQRPPFRRPPPPPPSPFLGVACAEAPMEAPHGSPSLSPVALDTSTLDLFDDILLTPTPRPLVTPDSFCQTLPAGNPQVASDVISHALGPGDQGQPTPIQAPRFSNLLLPPQKAQGGSLEPAALGCGWVDSWEAPYACDPQGVLDSWGAL", "length": 229 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GSB3-1", "protein_name": "Family with sequence similarity 236, member D", "gene_name": "Fam236d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVMHLVGHPQLTGTEGVATEGVATAHTMLTSRGPRDTREPAPPTRSWRSRFQRALARVSKFFRRGRRTARG", "length": 72 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GSI2-1", "protein_name": "Family with sequence similarity 236, member C", "gene_name": "Fam236c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVMHLVGHPQLTGTEGVATAHTKENSSRGPRETREPAPCTRSWRSRFQRAVARVSKFFRRRRRST", "length": 66 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1C7CYU6-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 2", "gene_name": "Zscan4-ps2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQYATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEGNVGESCSGNEMDSLLIIQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSVPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1C7CYV3-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 1", "gene_name": "Zscan4-ps1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWAIQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYTLTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNTSCNATEGNVGERCGGNEMDSLLIIQKEQHPEHEEGNVVCRFPHGARRASQGNSSHHVDFRSALTPADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSSDNIPRKKTDSLSINKRIYHPEPEVGDIPYGVPHDSTRASQGTSTCLQESLGECFSEKDPREVPGLESRQEEPISDPVLLGKNHEANLPCESHHKRFRRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCFTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1D5P3Y4-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLSALLRLAAPPKLPKGYRHGTWRPGTAAERLRNPPGQRRKKIFVEPISREDWKVFRGDTVQVLTGKDAGKQGMVTQVVRARNWVVVEGLNTHYRYVNRDAKYSSTYIASEAPLLLNQISLVDPEDRKPTEVDWRYTEEGERVRVSLRTGRIIPLPLWQRRDGIVPEQWIDGPKDTSVDDALDKTYTPSLKTFEEEIMDAMGIVETRRAKKSYWY", "length": 216 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A1D5PNZ8-1", "protein_name": "ODF3A protein", "gene_name": "LOC124417034", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPASMDGAWVGTWRPHRPRGLISAQFPSPGPQYSIPGTTGYVGHSPTKARAPAYTFRGTKPPAAGSCGPGPCYFVEPAITRNGKYVAPGAQLRGRPATKTTVTPGPSDYRTEAANRHVFKCPPVQSMAFRREPLRTDHPPGPGTYTLPRLMGPNTVYTSASPCYSVRGRSQRGRFDEDLAKTPGPAALPKVPVDAYKTRAPAYTMAARPKAGEGKAAKPGPADYSVGRVTLIKPQAPASTFGIRHSLYTTPLIVE", "length": 255 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A1D5RLF0-1", "protein_name": "F-box and WD-40 domain protein 27", "gene_name": "Fbxw27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METHLPSLPLMKIFSYLDAYSLLQVAQVNKNWNALASSDVLWRKLCQKRWLFCDMVTLQLQDKETWKQFFVYRTWQEHSKTRANPRDFTYKEIPLQYGPCGYACYISGCGITRKGQDKSVVCMVNSKNTISTWDVHKSVITWVSPEQPASIKLLTTLPEMHIAVTVDIQSTIKLWDCHNREALATNILESPCKSLKAVITKDDPIVLVSDILGNLYIFRIPDLHLISTVNVLPCDIDEIYCSPQKKWVLLSKKQPYILPKVFYMSSLLRTSEFSAPVSTLLEISLCQEAFWTPRREDRLTLMSRSGCSKITKFETYDMKLEEFGNKIIVKGNSIAGFLLPYYTESLNWFGVSDKDTIVCSTEFSLLLFTNNGHRLQTFQYFSETIVRLSVDPVHVIVTCNDGSLDVYAWEERSLLLRKCYRLKNRRHLSPRGFINKTLCDDVSIIQLMIDGHDTWFLMAYALNICS", "length": 466 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1P8ASP4-1", "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "PRP4KB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVSDKHVESNHRKHRRSFSPSDEVFKSPKRHKSRHHHRRHGHRHHRDEEVQYNDDENVNGGDLDMEEGEILGKEGIGETLKKKLESVDEFGDIKSGQFRENNLAFNGDDGFPLICKSWIRVYNYLSYKCHGRNQRRERECEKRKEIEPDRERRKERGSVDRDSRGDREKDYLRDRDNDRGRSRDKARYSSRERGRENERERRSEKDRDKGREFQSDREKHKSLDDGYGEVRHKHSGHSRHDAEDDLELRSPTSVNGHDPNSGDVKETRGNVERTRIDNDDKGDVVVWEVEQEDEELNLIEESRRRTQAIMEKYKKKLEQQNGFSSHDLELANIPKQSSTVADVLGSGTLGPVTSAVNQAKAGLDIDAVDGEVAKLSSAVGESPAQLVISDSDRTLASTGLGEGSPKDKISDDMFTDDIFGESPADSQKMVCTLTQIIDLVFIEFSNSGFICFVFPVHHLTRYSRNGLPFVHYIFVGYLRGKGNGIPIVRSGLDDNWDDAEGYYSYQLGELLDDRYEIMATHGKGVFSTVVRAKDTKAELGEPEEVAIKIIRNNETMHKAGQTEIQILKKLAGSDPENKRHCVRFLSTFKYRNHLCLVFESLHLNLREIVKKYGRNIGIQLSGVRVYATQLFISLKHLKNCGVLHCDIKPDNMLVNEGRNTLKLCDFGSAMFAGTNEVTPYLVSRFYRAPEIILGLPYDHPLDIWSVGCCLYELFSGKIMFPGSTNNEMLRLHMELKGAFPKKMLRKGAFIDQHFDKDLCFYATEEDSVTRKTTKRMMVNIKPKEFGSVIKQRYKDEDSKLLVHFRDLLDRIFILDPQKRITVSQALAHPFITGK", "length": 834 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A1P8BFV1-1", "protein_name": "Bax inhibitor-1 family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGLKDFSRISPAIQSHLMRVYFSLFCILAASAFGAYLHMRLNIGGTITKLGWVLSLLEHVVSCPPYKHKIRFSLLLLFGVLHGASVGPCIKSTIDIDSSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLLTWLKNSDQFASATVEIQMYLGLLLFVGCIVVNTQEIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIMWNTSADRIRRNNEET", "length": 226 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A1W2P6Q8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P7S8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKMRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLIGGLNTPLHESDFSGVTPQQQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLHINPEDGMADHSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQATRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPFDVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNDSEHITYLEHSPYEKFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSCYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLEEDVQRQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P7Z8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P855-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAIMKYRKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2PP81-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 5", "gene_name": "TAF11L5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A1Y7VLT7-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNQDEARSLKAYGELPEHAKINEMDTFGPGDDDEIVFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1Y7VNG9-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRHRGKNENESEKRELVFKEYGQEYAQVTKMLGCLWLEAMCFDGVKRLCHIRGKLRKKVWISTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINETDTFGPGDDDEIVFDDIGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YCH8-1", "protein_name": "Predicted gene, 47985", "gene_name": "Gm47985", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKRKQLLDKKAEDKQPPESRGNNGRSSKSSPMGKDNTWPSPEAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDRRSQPRSPVRTLKRSRSGDRQGAPHNSAKRHRQTSPPEASSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPIVLQRAWLTWQLSHAGAALHWALHTVKSILTSQASLPRYTWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 300 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YD13-1", "protein_name": "Predicted gene 8947", "gene_name": "Gm8947", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKREQLLDKKAEDKQPPESRCNNGRSSKSSPMGKENTWPSREAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDQRSQPRSPVRTLKRSRSGDRQGAPHNYAKRRRQTFPPEASCSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPSVSQRAWLTWQLSHAGAALHWALHTVNSILTAQASLPRYIWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 301 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YE43-1", "protein_name": "Predicted gene, 47996", "gene_name": "Gm47996", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKRKQLLDKKAEDKQPPESRGNNGRSSKSSPMGKDNTWPSPEAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDRRSQPRSPVRTLKRSRSGDRQGVPHNSAKRCRQTSPPEASSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPSVSQRAWLTWQLSHAGAALHWALHTVNSILTAQASLPRYTWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 300 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286ZIN6-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC110258935", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANLTSMSGFLLMGFSDDHKLQILHALLFLVIYLLALTGHLLIITITTLDHHLHSPMYYFLKHLSLLDLCFISVTVPQSIANSLMNNGYISLGQCILQVFFFIALASSEVAILTVMSYDRYVATCQPLQYETIMDPWACRQAVIAVWVTGGLSGLTHTAINLSVPLCGDRVIHQFFCDVPQMLKLACSYEFINEIAVAAFTTSTAFFCLISILLSYTRIFSAVLRIPSAQGRTKVFSTCLPHLLVVTFFLSAAGFEFLRPPSDSQSAMDFMFSIFYTVVPLTLNPVIYSLRNKAMKAALRKVLSKEEFAQRKKYFKALFQL", "length": 321 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZIP8-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259124", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "QEYKANGGDNTTTIIHFVLLGFSDFPHIRPALFVVFLVIYILTLTWNLCLIVLIRLDSHLHTPMYFFLSNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYFVCSTMGLSECCLMTVMAYDRYAAICNPLLYSSIMSPSLCGRMVLGSYMAGLSATLSQVCAVLQLHFCGPNVIHHFFCDMPLMLGLSCSDTFFVQVLTAIFTVFFGIINALVIMMSYVYIVISVMKITSAKGRSKAFNTCASHLTAVTLFYTSGIFVYLSSSSGGSSGLDRFAAVFYTVVIPMLNPLIYSLRNKDIKDALKRLKKRKECC", "length": 316 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZLI4-1", "protein_name": "C-C motif chemokine ligand 24", "gene_name": "CCL24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFSPSSLIKASGQLQCPAGNRLLAPTLSSCIAALSPELPLLLSRHGRPVTVAASLLFLGLCAYSFAPADSVTMPSSCCIYFISKKIPESRVASYQLSNSSVCPQAGVIFTTRKGQKFCGDPKQLWVQKYMKKLDAKRKKASTRIRAMGTGAPVRRGPANSTSI", "length": 163 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZSE3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258059", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNRTITTFILLGLTDDPKLQVLIFIFLFVAYMLSLTGNLTIITLTFVDSHLKTPMYFFLKNFSFLEISFISSCIPRYLYSIATGDKVITYNACVIQVCFTDLCGVTEFFLLAAMSYDRYVAICKPLHYVTIMSSRVCGILISSCWMAGLCVLIPPLSLGLNLKFCDSNRLDHFGCDAFPLVKISCSDTWPMEQTVIICAVLTLNMTLTCVVLSYAYIIKTIFRFPSVQQRKKAFSTCSSHMIVVSITYGTCIFIYMNPTAKGEVTIKKVVSLLIFSVSPTLNPFIYTLRNNQVKRAFKDSIKRIALLSTR", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZU87-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100152920", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGENQTVLFEFIILGFSNLKELQFLLFTIFLVTYICTLGGNSFIILETMTNLHLHTPMYFFLENLAFLDICYTTTNVPQMMAHLLSEKKSISYLGCMAQLFAFIFFVGSESLLLAAMAYDHYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSTVHTVLTFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSAIFTYGRPISTYSLEKDRLISVLYSIVTPMLNPIIYSWRNKDIQEAMQVMGRKWKASSSLSFDV", "length": 318 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZVC9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258401", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNSTSLHDFILLGFSDHPKLEMALSGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFLDLCFTTSIVPQMLVNLWGPHKTISYGGCVIQLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKIACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSRAGQRKAINTCGSHLTVVSIFYGAIIYMYLQPGNNASRGQVIFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZWC4-1", "protein_name": "Zinc finger protein 16", "gene_name": "ZNF16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPLSQVPAMPSLRTRPGKAEMEPSVPGPSLRTPGTQVSVSDAPAVTHPGSALHGPLSCGDTEPGATPPHHQLADWDLRTEGSQLLQKEDASEDLESQAGTSEDYVGAGSQAPERGELCADVLGSDWGVPQGERLSLCQEGGFMPAYLLPGSPLEEPEIDTEPLERNFGLIITPVASPGEPEEETPQPFDACDQSVHCGVDLAGHEGLHAAESSFICGECGESVGLHSDLLRHRLSHRGEKPHVCAECGEAFSQSASLESHQRSHEPAKPFQCSTCGKAFGRSSSLIKHHKVHTRERPHACGECGRPFSRFSNLVKHRRVHTGEKPYRCSECGKAFSQSSSLLQHRRVHTGEKPHVCPVCGKAFSYSSVLRKHQIIHTGVKPYSCSACGKAFSHSSALIQHQGVHSGDKPYECRECGKTFGRSSNLILHQRVHTGEKPYECAECGKTFSQSSTLIQHQRIHNGLKPHECDQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYKCGECGKAFSQRSVLTQHQRVHTGEKPYDCEACGKAFSQRSKLVKHQLIHARE", "length": 576 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZX75-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100156955", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "IFIMEWENQTASSDFILMGIFSHTPTHIFLFSLVLGIFTVALLANTVMVLLICLDRRLHTPMYFLLSQLSLMDLMLICTTVPKMARNYLSGRKSISVAGCETQIFFSVSLFGAECFLLAVMAYDRYAAICYPLQYPQLMNWNVCGLLAASSWILGVFDGIVDIAATLSFSYCGSREIPQFFCDITALLRLSCTDTSTFETLVFICCVVMLLFPLSLIIISYTRVIITVIRMSSGEGRHKAFTTCSSHLVVVGMYYGAAMFIYMRPTSNRSPAQDKMVSAFYTILTPMLNPLIYSLRNKDVAKAFSRCWGREI", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZY56-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258501", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METDNDTQILEFLLLGFSKQPESQPIIFGLFCSMYLITVFGNLLIILAVISDYHLHIPMYFFLSKLSFVDICFTSTTIPKMLWNIQTQSKAITYEGCITQIYFLILFAVLDILLLTVMAYDRFVAICHPLHYTVIMNPRLCGLLVLVPWIMSVLNSLLQTLMMMQLSFCTNFEIPHFFCELNQMIQLACSDTFLNTIVMYFAAALLCGGPFFGILCSYSKIVSSIYRISSAQGKYKAFSTCASHLSVVSLFYCTMLGVYLSSAAAHSSHSSATASVMYTVITPMLNPFIYSLRNKDMKRALKALFVKGPM", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZZP6-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANAPSEIQGVSPKDESTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLMKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEVSAWNKLQFYHNPNFKRGCPHLLVRMKRRVRVKNASPVSASVLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSASTNLNVPLIRWPSMSQRISNTTTPTRSGLSSPSSPSFRPPGQIAMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYRCISYFPSGYFGLRVEPSPLPTRYQNISPTEGPVSNPQPAAHPWFPMPMATDTSAASLSRPNPQSSSVSEHLPNYH", "length": 402 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A7E2-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258743", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNSTSLHDFILLGFSDHPKLEMALSGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFPDLCFTTSIVPQMLVNLWGPHKTISYGGCVIQLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKVACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSRAGQRKAINTCGSHLTVVSIFYGAIIYMYLQPGNNASRGQVIFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A7J9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258750", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTEVKEFILLGFAGQHKSWLVLFIVFLGIYVVTLVGNIGMILLIKIEASLHTPMYFFLQNLAFVDLCYATAITPKVLQNLMSTEKSISFIGCMVQLFVYGTFVTSDGYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIGSCFMGFLNACVNGSLTFQLNFCKSNKINHFFCDAPPILALSCSSIYFNIMLLAAFVGFNLMFTVSIIIFSYIFILAAILKISSAAGRKKAFSTCGSHLTAVTIFHGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMLNPLIYSLRNQDVREALKEIGKKML", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A951-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "LOC100514137", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVHMNVLTDALESINNSEKRGKRQVLTRLCFKVIVRFLTVMMKHGTPIGKFEIMDDPRARKIVVNLTGRLNKCGVISPRFDGQLKDLEKWQNKLLPSCQFGFIVLTTSAGIMHHEEAR", "length": 118 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287ACV2-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHAPSEIQGVSPKDAPTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLIKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEDSAWNKLQFYHNPNFKRGCPNLLVRMKRRVRVKNASPVSASLLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSTSTNLNVPLIRWPSMSQRISNTTTPTRSGLSSPSSPSVRPPGQIVMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYHRISNFPSGYFGLRVEPSPLPTRYQNISPTEGPVSNPQPAAHPWFPMPMATDTSVASLSRPNPQSSSISEHHPNYY", "length": 402 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AEV7-1", "protein_name": "Uncharacterized protein", "gene_name": "WFDC10AL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKWWGLQWLMLSCLAILPASGNWQERISASLEALTQSKLIPGMKPCKTIPTKEQCTYFCDLPRACPTGLLCCSASCGNVCMPPKGHGNRRSSHKISNFLFTAEPIKQQ", "length": 108 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AF12-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTNTKGKRRGTRSMSSSPFRKHGVVPLATYMRIYKKGDIVDIKGMGTAQKGMPHKCYHGKTGRVYNVTQHAVGTVVNKQVKGTILAKRINVHIVHIKHSKRGDNFLKRVKENDQKKKEAKEKVTWVQLKHQTAPAREAHFVRTNGKEPELLEPNP", "length": 155 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AGK9-1", "protein_name": "DM domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPDEMPTVPCCPLDSTTGLETGAPWGIEFGPRRAIRRCARCHNHGITDQIKDQEHLCLFQACECHKCVLFSEHCSILPAESALKTMQELHLKRQLTQGLIKSGTTSPKAHSHVKKSSIQTGVLSKLPRCSADRSGIGIFVSVLDSSTLEEATNNFTFQEVTQAPCPAQQAPKTSDQDSDSASLEWQRKLEAAEALLTLRESSQAPSGPTPLLQPSAAPAPAGERGLQPPSRSLRPRPASSISLPIGHVGCISLLS", "length": 256 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AKK8-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100155397", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDVRNHSIVSEFVFLGFTNSWEIQLLLFVFSFLFYSSSMMGNLVIVFTVTLDSHLHSPMYFLLANLPAIDMVFCSITAPKMIGNIFKKHKAISFCGCITQIFFTHAAGGTEMVLLIAMAFDRYVAKCRPHHYLTIINPRICLCFLVTSWIIGLIHSMAQLFFVVDLPFCDLNVLDSFYCDLPRLLRLACTDTQELQFMVTVNSGLLSMGSFVLLIISYIFILFTIWKHASGGSSKALSTLSAHITMVVLYFGPLIFFYTWPSPTSHLDKYLAIFDAFITPFLNPVIYTLRNKEMKVAMRRLFSHLVHYRNIS", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AP00-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258730", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "SRHDLHCSLWQDNSMSVKRFAFARFSEVTEQCFLLFTLILLMFLASLTGNALIATAIWTNPVLHTPMYFFLANLSLLEIGYTCSVIPKMLQSLVSEARGISREGCATQMFFFAFFGISECCLLAAMAFDRYMAICSPLHYATRMSRGVCDHLAMVSWGVGCMAALGQTNYIFSLDFCGPCEIDHFFCDLPPILALACGDTSHNEAAVFVAATLCISSPFLLIIASYGRILAAVLSMPSPEGRRKALSTCSSHLLVVTLFYGSASVTYLRPKASHSPGIDKLLALSYTVVTSMLNPIIYSLRNKDVKAALRRTLGKKKVLAHR", "length": 322 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287ARD5-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258934", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGKNQTALSEFIILGFSNLNQLQFLLFTIFFLTYICTLGGNTFIILVTVVDPRLHTPMYHFLGNLAFLDICYTTTNVPQMMAHLLSEKKSISYGGCMAQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLTFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLFYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPIIYTLRNKDIKEAMKAVGRKWQLPLLSFDV", "length": 317 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AT12-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSFNRTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFLILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLDRCITQFFIIHCIFMSESGILLVMAFDRYVAICYPLRYTTILTHTLIGKIGVTIFLRSYCTVFPIIFLLKRLTFCRNNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLFLDILLIFVSYMLILRAVFHMPSQDARHKALSTCGSHVCIIILFYGPGILTTLAQRFGRHIPAHIHILLANVCVLAPPMLNPIIYGIKTKQIQEQVAHLFLKQK", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AUC4-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERINKSHPEEFILLGFADRPWLELPLFIILPMYFFLTNLSFLDMCYTTSIVPQMLFHLGGSEKTISYLGCAVQLYFFHTMGGTECLLLALMSFDHYVAICKPLHYTLIMNRCTCILLVATVWLSGMTYAVSEATVTLHLPLCGHNTLDHLICEIPVLIKAPCGEKGTNELTLSVVCIFMLAVPLCFILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVFFFYGPDISMYLQPPSSISRDLPKFMALFHGVVTPTLNPFIYTLRNKDVKGAWGNLVRSVFTSK", "length": 286 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AXC2-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTEVNEFILLGFAGQHKSWLVLFIVFLGIYVVTLVGNIGMILLIKIEMLQNFVGTEQSISFIGCMVQLLIYGAFVTSDCYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIGSYLIGFLNASVHVSFILPLNFCKSNKINHFFCDAPPILALSCSSIYFNVMLLAAFVGFNLTCTVLVVIFSYIFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMFNPLIYSLRNQDVREALKGVGKQCF", "length": 281 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AY25-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100155405", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHTNESVVLEFVLLGLTNSWELQLFLFAIFSIVYVTSVLGNTMIIVIIASDSRLNSPMYFLLSNLSFIDICQSNFATPKMLVDFLVEHKTISFEGCMAQIFLLHSFVGSEMMLLVAMAYDRFIAICKPLHYSTIMSRRLCIIFVFISWAVGILHSVSHLAFTVDLPFCGPNEVDRFFCNLPLVIELACMDTYKVEILTLTNSGLISLGCFLALIISYTVILITVHRWSSSGSSKALSTLTAHITVVILFFGPCIYFYIWPFSRLSVDKFLSVFYTVCTPLLNPIIYSLRNEDVQSAMHKWRNHHVNSWKY", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287B1Z6-1", "protein_name": "Short stature homeobox", "gene_name": "SHOX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEELTAFVSKSFDQKSKESSGGGGGGGGKKDSITYREVLESGLARSRELGGSDSNLQDITEGSGHCPVHLFKDHVDNDKDKLKEFGTGRAAEGIYDCKDKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTASHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL", "length": 292 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287B9C9-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHAPSEIQGVSPKDESTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLMKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEVSAWNKLQFYHNPNFKRGCPHLLVRMKRRVRVKNASPVSASVLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSASTNLNVPLIRWRSMSQRISNTTTPTRSGLSSPSSPSFRPPGQIAMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYRCISYFPSGYFGLRVEPSPLPTRYQNISPTECPVSNPQPAAHPWFPMPMATDTSAASLSRPNPQSSSVSEHHPNYH", "length": 402 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BB76-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100157512", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHTNESVVLEFVLLGLTNSWELQLFLFAIFSIVYVTSVLGNTMIIVIIASDSRLNSPMYFLLGNLSFIDICQSNFATPKMLVDFLVEHKTISFEGCMAQIFLLHSFVGSEMMLLVAMAYDRFIAICKPLHYSTIMSHRLCIIFVFISWAVGILHSVSHLAFTVDLPFCGPNEVDSFFCDLPLVIELACMDTYKIEILTLTNSGLISLGCFLALIISYTVILITVHRWSSSGSSKALSTLTAHITVVILFFGPCIYFYIWPFSRHSVDKFLSVFYTVCTPLLNPIIYSLRNEDVQSAMHKWRNRHVNSWKY", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BC21-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152520", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGKNQTALSEFIILGFSNLNQLQFLLFTIFFLTYICTLGGNTFIILVTVVDPRLHTPMYHFLGNLAFLDICYTTTNVPQMMAHLLSEKKSISYGGCMAQLFAFIFFVGSECLLLAAMAYDRYVAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLAFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPIIYTLRNKDIKEAMKAVGRKWQLPLLSFDV", "length": 317 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BF45-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100513333", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNRTITTFILLGLTDDPELQVLIFIFLFLAYMLSLTGNLTIITLTFVDSHLKTPMYFFLKNFSFLEVSFISSCIPRYLYSIATGDKIITYNACFIQVCFTDLCGITEFFLLAAMSYDRYVAICKPLHYVTIMSSRVCGILISSCWMAGLCVLIPPLSLGLNLKFCDSNRLDHFGCDAFPLVKISCSDTWPMEQTVIICAVLTLNMTLTCVVLSYAYIIKTIFRFPSDQQRKKAFSTCSSHMIVVSITYGTCIFIYMNPTAKGEVTIKKVVSLLIFSVSPTLNPFIYTLRNNQVKRAFKDSIKRIALLSTR", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BGE2-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENNQSWIAEFILVGFQLSEEMELFFFIIFFLLYIFNLLANGMILGLICLDPRLHSPMYYFLTHLAVTDISYASSNLPNMLENLVKHKKTIPFVSCTLQMLFYLAFASVECLILVVMSYDRYVAICHPLQYTVIMNWKLCTVLAIISWACGFFLALVQVSLFLRLPFCGPQKVNHFFCEIRSVLKVTCGETWINKIFLFADGVFILVTPISLMLVSYVRILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGIAMMVYLVPDDSHQQEEQQKILFLFYTFFNPLLNPLVYSLRNAQVKAAFHRIFQKNRTM", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BIM6-1", "protein_name": "Histone H2A", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGKRSRRKSPGRQGRTCARTTRAGLSASVSHMERLLREGPYAQCLSSSARVFLAATIEYLTARVLELAGDEAQIVGRRCITPELVAMAVHNNALLSAFFGTLAISQVAPTQE", "length": 113 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BK27-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVTEFIFLGLSNSQELQTFLFVFFLVFYVGIVFGNLLIVLTVMIADFFRKCKVISFKGCLAQIFLLHFFGGSELVILIAMAFDRYVAICKPLRYTTIMSSNVCVGIVAAAWGTGFLHSVSQLAFAVNLTFCGPNEVDSFYCDLPRVIKLSCTDTYRLDIMVIANSGVLTVCSFVLLIISYTVILVTIQHLPSQKSSKALSTLTAHITVVLLFFGPCIFIYAWPFPIKSLDKFLAVFYSVVTPLLNPIIYTLRNKDMKTAMKRLRKWNMNSRIKP", "length": 274 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BKA6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259008", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTFNCSLWQDNSMSVKRFAFARFSEVTEQCFLLFTLILLMFLASLMGNALIATAIWTNPVLHTPMYFFLANLSLLEIGYTCSVIPKMLQSLVSEARGISREGCATQMFFFAFFGISECCLLAAMAFDRYMAICSPLHYATRMSRGVCVHLAMVSWGVGCMVGLGQTNYIFSLDFCGPCEIDHFFCDLPPILALACGDTSHNEAAVFVAATLCISSPFLLIIASYGRILAAVLSIPSPEGRRKALSTCSSHLLVVTLFYGSASVTYLRPKASHSPGIDKLLALSYTMVTSMLNPIIYSLRNKEVKVALRRTVGKKKVLAHR", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BKW4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258932", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGENQTVLFEFIILGFSNLKELQFLLFTIFLVTYICTLGGNSFIILVTMTNLHLHTPMYFFLENLAFLDICYTTTNVPQMMAHLLSEKKSISYLGCMAQLFAFIFFVGSESLLLAAMAYDRYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLAFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSTIFTYGRPISTYSLEKDRLISVLYSIVTPMLNPIIYSLRNKDIQEAMQVMGRKWKASSSLSFDV", "length": 318 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BLZ6-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC110258167", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGGKNSTTITKFILLGFSEFPKLTAVLFSVFLRISLMTVSWNMGLIMLIRMDSHLHTPMYFFLSNLSLLDICYVSTIAPRMLSDFFKKYKFISFMGCTMQYFFSSLALTECCLLAAMAYDHYAAICNPLLYTAIMSPTLCVQMVAGSCVTGFFGSFIQLCALFQLHFCGQNVTNHFFCDLPQLLILSCSDTFFFQVMTSVLTVIFGLTSVLVIIISYGYIIATILKITSSEGRSKAFNTRASHLTAVTLFFGSGIFIYMYPNSGDSLSQNKLVSVLYTVIISMLDPLIYSLRNKEIQDSLSRWRKTIFSWCY", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BNL4-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "TVLNARNVSTPKVFILLGFSDHPWLEMPLFIIVLAAYIRTLVGNISIIVVSRVDPNLDSPMYFFLSNLSFLDLCFTTTTIPQLLLNLWGPDKSISYGGCVTQFYMFHFWGATECIFLAVMSMDLQAICKPLRYPVIMHQQLCIFLVVMAWLSGLVNSLLQSSLTIQLPLCGNNKVDDFLCEVPVMIKMSCTDTTFNVAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIQSSEGKKKAFNTCSSHTIAVSLFYGPVISMYVQPSAANSQDKNKLMSLFYSLVTPMLNPFIYTLRNKDMKGAMMRLLVSLYHQRRG", "length": 315 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BSD4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100525471", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENENSTVVAEFIFVGLTQSRNIQLLVFVLILIFYLIILPGNFLIILTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEMLLLVVMALDRYIAICRPLHYSTVMNLRACYALLVALWLGGFVHSIIQVALILHLPFCGPNRLDNFFCDVPQVIKLACTDTFVVELLMVFNSGLMTLLCFLGLLASYAVILCRVRGSSSEGKTKAMSTCTTHIIVIFLMFGPAIFIYTRPFRAFPADKVVSLFHTVIFPLLNPVIYTLRNQEVKTSLKRLLNQQLA", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A2R8VHJ9-1", "protein_name": "Predicted gene, 36245", "gene_name": "Gm36245", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTKNEEQNEDQSEGVVIPHIQDHHCLAILAFCFFFPLGYLAYRSSCKTRTYIEQKEYEKAKATSRCTFAFVLSSIAGGSIIFFCLFSRLFFM", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A3L7ICH5-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "LOC100756118", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYYKFSGFTHKLAGAWALESYSPQGLKPVASTEAPPIVFATPTKLTSSVTAYVYAGKNKVPELQKFFQNFFHLKRGLPDQMLYRTPMALTVGGTIYCLSALYMASQTPNK", "length": 110 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A3Q1LL21-1", "protein_name": "BTB domain-containing protein", "gene_name": "LOC112445444", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGPLNSRNLQCRESGTGELQQPEAQAGPSYVSGSRKRKQSTGPSLGPESEMSHNQEEDLQQVVCTRQGKKVKIKSEYAYQTLFLNGETSDIKIRALGKVWCLHKRFLCQSDYFATMFRDSGKECHKDIIDLEINDQNINVESLQFVLGSLYRNEYVLIKPLQVPRVLATACLLQVEDLIQQCDKTMKETINVKTVCSFYVAAETYGLHSVKTGCFEWLLHNLMTHPSVELYKKLSTDLMNLVISSSNLFVMQKEIDIYTTLKQWMFLRLNPGWKGTMKQLLVNANNWFSRHKEHDGSISFLETKQGIVFQPVFKNLRFQHIICDLASTKVIEQDALIPSEWLSCVYKRQWYTLLRAQQYREIGPRDITETELEEYSMRCGKRIVRDGTYAWKWSGYNFGVHLYVVFTSHFIIFKRHAFSQPYDGSICLQPQRNIAFRLTLVYFGSSGKLSFRKTTGYKILTFEKDEEQMVMKLDSVALSFPLYIFCNFLFISLENPGN", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1LLV6-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIIIGTLITGYMVTCTCFLHYSCDSEEAHKATKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKPTWPPSLQCRVKPTKTPLPYPKNQSFPEHSSADKLTKRQRYLKLKCPASAGRAEILSRPQPVKFCRCYKEKCLVCRAVSEPFITHVSEANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSPNN", "length": 361 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1LUU6-1", "protein_name": "Guanylyl cyclase domain containing 1", "gene_name": "GUCD1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MTGPRCRRKQRPSGRPGPRGTRAPQHPTPDAGWTARRAAGAAGAEARGRDLPPQRKPAKPTAPGKGRPERGECPRRADRGGGDPEERAGGRPAWGPGAGRGGAWGRSRLPPLLPPGRWCWRPGKPARAGRALSSPVDARAAAGAGPGPWEPRAARVMRTEVDAEAAGPPLEPDEPTQSLSIQDQETAFLLEDSCQLKPGQPLPGRPWPSGDFVQLPVPIIQQLYHWDCGLACSRMVLRYLGQLDDAEFEQALQELRLTRSIWTIDLAYLMRRFGVRHRFCTQTLGVDKGYRSQSFYRKHFDTEETRVNQLFAQAKTCKVLVEKCRVSVQDIQAHLAQGHVAIVLVNSGVLRCDLCSSPPKYCCFTPSGPRCFCRSPDYQGHFIVLRGYSRAAGCVFYNNPAYADRMCSASISNFEEARTSYGTDEDILFVYADS", "length": 434 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1M0W3-1", "protein_name": "IF rod domain-containing protein", "gene_name": "LOC787600", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MTCGSACFSSRSGVRSSSSCVTTQRYAPGRTFSCVSACGPRPSRCCITAAPYRGVSCYRGLTGGFSSRSVCGGSRAGSSSRSFGYRSGGPSPPCITSVSVNQSLLKPLNLEIDPNAQRIKHQEKEQIKSLNSKFAAFIDKVCFLEQQNKLLETKWKFYQNQRCCESNLEPLFNGYIETLRREAERVEADTGRLASELNSLQEVLQGYKKKYEEEVALKTTAENEFVKIKQEVNRAYVLKGDLEANAHSLVEEVGFLKTLYEEELRVMQAHISDTSVVVKMDNSRYLNMDSIVAEIKAHYDEIASRSRAEAESWYRSKYEEIKATVIRHGETLRRTKEEINELNRLIQRLTAEIENAKSQNSKLEAAVTQAEQQGEAALNDARGKLAGLEKTLQKAKQDMACLLKEYQEVMSAKLGLDIEIATYRRLLEGEEQRLCEGISAVNVRVSSSRGGVVCGDLSATRTCGIGSYGVGACGSSCKKC", "length": 480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MFB0-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC112441459", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTRAEFKQTKLQELWRRLLIIVIGTLITGYMVTCTCLLHYSCDSEEAHKAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKSTWPPSLQCRVKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVTLFSRELKHFYKSYKKKQPIYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDMFKNSQNN", "length": 361 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MI36-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGSSSGSKAEFIVGGKYKLVRKIRSGSFGDMYLAINITNGEEVAVKLESQKARHPQLLYESKLCKILQGEVGIPHIRWYGQQKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMMGRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASISAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRHLFHILFRTLNHQYDYTSDWTMLKQKAAQQAASSSGQGQQAQTPTGF", "length": 325 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MQ28-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "KEQVLQPTTVVSLEGAVAEISCNHSVSDVYDFFWYLHFPGFAPRLLIKGLGPSQQGRYNMTYERFSSSLLILQVQTADAGVYYCALRYTEAGHP", "length": 94 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MT47-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC112444909", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MLGCEGGKRPLKPPKKQAKETDEEGKAFKHKQKEEQKTLEGLKGQIMGKVPLATGGIKESGKQ", "length": 63 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MUP8-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "LOC100336539", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSRLTERALPTGTSNGAPSSRRAPVLTGTTVSNNDLASLFECPVCFEYVLPPITQCKSGHLVCGNCRPKLTRCPTCRVPLTSIRNLAMEKVANLVLFPCKYTSSGCGKTMPPTEKADHEEHCEFRPCRCPCPGTSCGWQGSMDAVVPHLMQHYNESIITLRGEVVVFLAVNINLAGTLEWVMLQSCFGFHFLLVLEKLEIYDGHQKFFAVVQLIGTREQAENFTYQLELNGNRRRLSWEATPLSIHEGIATALINSDCLIFDSEVAELFAENGNLSIDVTISMC", "length": 284 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q2TUK0-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC121109925", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQQGHGERGNWQTKVWKTVALVLVTVAVASFGVYCVGGLVEGIKTTAGVTARLVRRDGEIVSLDEELAKVQRQLHVLQWRARDITERALHEALRRTELPGFTGEAVQKIIHQVLEKLEESPFQMTNYASKTSGAAIVRSKTSPSWIGSGRVFWQSLPLVAYMRPPEVILEPDNHPGNCWPFPGSQGHVFIKLPVAVFPTAVTINHGVPAAAYHADSISSAPKDFAVYGLQEEDDEKGTLLGEFIFMPGQAPGQTFQLKNEHSAFIKYVRLQVLSNWGHPEYTCVYQFRLHGDPAPDGDARGKLSA", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A3Q2UEY0-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418381", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMPALLFTLLHYWKIWLCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEPEEQQEQVEQEEQLERVEELERVDQVEHVEQEEREDQGEQVQQEEQVEEVEREDEEDEYFYHSALTRYIARRAWEKMQGRATKCVLVEELMRDLLQTFTFVCPNSFYPVLQPAIGVGSAFEGWSPCEEDIVYHLLVPIKAPHGHVFHPELGEEGDMLARNSRIRVELVCMCTREQQLGDVLCFLHHSQEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRIWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAVFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSSYTIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKLLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRALRDFKELKDRLFRLLLFGR", "length": 539 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A494C0N9-1", "protein_name": "Protein FAM246B", "gene_name": "FAM246B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATPGRPWAQARSAYRASEVLRRVTGRRRDPGPQSNGPGREDARAPGRLARLLRQLRAEAASRSEVPRLLKLVERAGAGAAGAGERTGAHSRGSVCSVCGEPRGRATYPAGVLEVSERRLQEGLAAVREELGAEIEALRAELRAELDALRALLPPPPPSPPARREPRAVPRAAPRGPTLLRTLGTVSALVAASRPADDAPDGPAECGAHRAPARKNHKKMPVPPGAPQGGGD", "length": 232 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A494C0Z2-1", "protein_name": "Speedy protein E13", "gene_name": "SPDYE13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A4X1SRU7-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNLFIYVLLLSVWTNSCLDTNQSDETSTAGAKHRESMETKMDTFRKHLLIIVIGIMTIAFVFTCLCLLHYNCLSDDVPKAGTVKKEDIKAKSSRSSKISFSDSKTASLCDPEKQSMPSSIDKLPGLSSPEKASIPSSAEKLTKPSSQEKSCTPESPKKVFRSSCQGKSHRTCSPDKARKRAHAHKEVGQVSSSYPSKAVRPPWQPSPQHPVSPTNSPCPPYPQNQTLSNPSSLSKLTKSHRYHKLKRSVNTGRAERLSRPQSVKSCRCCKEKCLIYRAASGPLVNNISEAKKKNAQSPPFPHKLKPFPKPFHKIDSRDNVSCGNASDHDMLTHDSDGDSDREITIICNMKRKEFIY", "length": 356 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1TRA8-1", "protein_name": "Small ribosomal subunit protein eS19", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGVTVKDVNQQEVVRALAAFLRKSGKLKVPEWVDTVKLVKHKELAPYDENWFYTRAASTPRHLYLWGIAGVGSMTKTYRGHQRDRVMPSHFSRGSKSVAHRLLQAREGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAAKKKH", "length": 145 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1TY10-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100627324", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENYNQTSIYFILLGLFPSSRIGMFLFIIIVLIFLIALFGNFSMILLIFLDNNLHTPMYFLLSQLSLMDLTYISTIVPKMAYNFLFNDKSISFIGCGIQSFFFLTLAGAEGLLLAAMAYDRFVAICFPLHYHIRVSKRICVLMIIGSWIMGSINSFAHTAYALNIPYCQSRAINHFFCDVPAMLTLACIDTWVYESTVFVSTTIFLLVPFTCIAFSYGRILLVVHHMNSTEGKKKAYSTCSTHLTVITLYSAPFAYTYLRPKFLRTPTEDKVLAMLYTIFTPMLNPIIYSLRNKEVMGALRRVIQRICSVKM", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1U699-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524234", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSSVSMSKFVLVGLHIWPEQQGMVFALFLGMYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLAFSDVSFSSVTVPKMLMNMQTQDQSIPYAGCVTQTYFFIFFSCIDNLLLAVMAYDRYVAICHPLRYAIIMKEELCLCLLAGSWLLSCAYALTHTLLLAQLSFCADNIIPHFFCDLASLIKLSCSDTSLNELVIFSLGPAVFIFPLSGILVSYGCIVVSILSVHSPKGIFKALSTCGSHLSVVSLFYGTSMAVYLSSSSGQSHDKDTIASIMYTVVTPLLNPFIYSLRNRDMTLALQILFRNSNLLAK", "length": 315 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1VK25-1", "protein_name": "Elongin-C", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "RSYGGCEGPDASYGKLIASDKFIVKREHVLTSGAIKAMFSSPGQFAEKETDVVNFRETPSGIPSAALWKVCMYLPHKVCYTSNTSEIPEFPINSEFPIAPDIALEPLMAANLLDC", "length": 115 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A571BD55-1", "protein_name": "BTB domain containing 35, family member 26", "gene_name": "Btbd35f26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSVYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BF50-1", "protein_name": "WD repeat domain 88", "gene_name": "Wdr88", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKDNEEILNSPDQVRKGSPDVKKKKKIKKKRVKPKGDLDSKKLDFVEDSWWKGSLKNKNLDFAEYNWVLVDNRRVSVDSRKSSADSKRGSADSKRGSADSKRGSADSKRGSADSKRGSVDSKRGSVDSKRGSVDSKRGSVDSKRGSVDSKNRFSPKKMDFSEDREISQPTFLRAQQSKVPWALMRALGLFKLSLPDIRRYYNLTSHDPLALDKDRQPREKSHMATVKKFWGNQQPLSKIPYKILIGHDHIVSSCHFCMNDTRFLSSSYDCSVKLWDAEDGTVIWDFEPRPKAPVLECSITADNRRIVASSYDKTVRAWDVETGQLLWKVRHDTFVVCCKFSPNGKFVLSALDVDRGIYLMDPENITTVIHMKDHHQRSITSCCFDPDSQKVASVSMDRCIKIWDITSRTTLFTIPKAHYNAISDCCFTSTGHFLCTSSWDKNIKIWNVHTGEFRNRGACVTLMKGHEGCVSSCCIARDSSFLISGGFDKTVAIWDVGGGYRKLALKGHEDWVTDVAISNNKKWILSASKDSSMRLWNIEEIDKIPLVSENKKAMGLKVRQVGIR", "length": 565 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BG45-1", "protein_name": "BTB domain containing 35, family member 25", "gene_name": "Btbd35f25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGLQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BG86-1", "protein_name": "BTB domain containing 35, family member 8", "gene_name": "Btbd35f8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESRHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A5G2QG78-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100523228", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRGENTTNITDFVLLGFSDFPQIRAALFVVFLVIYILTLTWNLCLIVLIRMDSHLHTPMYFFLRNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYFVCSTMGLSECGLMTVMAYDRYAAICNPLLYSSTMSPSLCGRMVLGSYMAGLSASLSQVCAMLQLHFCGPNVIHHFFCDMPQLLVLSCSDTFFLQLLTLVLTVIFGILNALVIMMSYVYIVISVMKITSTKGWSKAFNTCASHLTAVTLFYTSIIFVYLSSSSGGSSGLDRFAAVFYTVVIPMLNPLIYSLRNKDIKDAWKRLKKRKECC", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QIN7-1", "protein_name": "ADAM metallopeptidase domain 7", "gene_name": "ADAM7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNSHYLSALFSREFLASNYSETYYSTKGEEVTTHPQIMDHCFYQGSIIHEFDSAASISTCSGLRGFFRVNDQRYLIEPVKYSDEGEHLVFRYNPKVQHAANYSCTELNFTRTAVLKDNTKSMEDSKMESIEKEKHIELFIVADNNVYHRNPNSKVRNRVWGMVNFVNMIYKTLDIHVTLVGLETWTNGDKIEIDSNIETTLKRFSAWQEIILKKKKNFDHVVLLSGKWLYTSAQGTSYPGGMCLPYYSSSVVKDLLPDLNTIASRMAHQLGHSLGMKHDDYPCTCTLGKCVMDSGGSIPALKFSKCSRTQYQQYLKDFKPTCMFDIPFSDKLSDYPYCGNKKLDDGEECDCGPVQECTNPCCDARKCMLKPEFTCAEGECCESCQVKKAGSLCRPAKDECDFPETCTGHSPACPKDQFQVNGFPCKDAKGYCFMGNCPTRDDQCSELFDNEAKDSSDICYKMNKNGNKFGYCKNEEQTLIPCEEKDVKCGKIFCTGGKHASILGEEKVYHLKKPLTQNVTECKTFFLYHKSKDFGLVAPGTKCGEGKVCSNSECVTIEKAYNSTDCPSPCNENAVEDGDLGCQCEGVQASVDWEETLNVTNISILVVVLILVIIGVLSAVLLIRYQKCIKLKQVQRPPSEALGVENKGYTGDEQQTRTEPILPDIHPLHRRTAESLARLPTSFSSPHYITLKPASKEPRGTADPNPSAKVSLKLDIQNGCASLS", "length": 725 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QM02-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100623139", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGGENTTNITAFVLLGFSDFPHIRAALFVVFLVIYILTLTWNLCLIVLIRMDSHLHIPMYFFLSNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYVVFSTMGLSECGLMTVMAYDRYAAICNPLLYSSIMSPSLCGRMVLGSYMAGLSATLSQVCAVLQLHFCGPNVIHHFFCDMPLMLGLSCSDTFFVRVLTAVFTVIFGIINALVIMMSYVYIVISIMKITSAKGWSKAFNTCASHLTAVTLFYTSGIFVNLNSSSGGSSGLDRFAAVFYTLVIPMLNPLIYSLRNKDIKDALKRLKKRKECC", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QUE5-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524011", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSNVSKFLLLGLPIQQEQQGMFFALFLGVYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLALTDISFASVTVPKMLMNMQAQDHSISYAGCVTQTYFFMFFACIDNLLLTVMAYDRYVAICHPLRYTIIMREELCICLLAGCWLLSCAYALTHTLLLAQLSFCVDNIIPNFFCDLAALLQLSCSDTSLNELVIYTSGAAVFIFPPSGILVSYGRIGISILRVPSTKGICKALSTCGSHLSVVSLFYGTIMALYFSPSFGQSHYKGIIASVMYTVVTPMLNPFIYSLRNRDMTLALEILIRNKNLFTT", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QWK6-1", "protein_name": "Calmodulin 3", "gene_name": "CALM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "VSAEREEEGVALKFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEVTASPVLGPAREGPRASAPSWGGKQPLAIACNQPRRSSGFSWDLPSFENLLSSTLWSPASGDGRGVEHSGRPS", "length": 214 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2R7Y6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524140", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLVAVSGNTLTILLICADPRLHTPMYVLLSQLSLMDLMHVSTTIPKMAINHLSGTKSISFVGCATQYFLFLSLGGAECLLLTFMSYDRYVAICHPLRYAVLMNRKVGQMMAVMSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYEIAVYIGDIVLLLLPIVLISASYVFILHSVIHMHSAGGKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALKRVLGREMITQNPKVRLP", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2RGH3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524855", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLIAVSGNTLTILLICADPRLHTPMYVLLSQLSLMDLMHVSTTIPKMAINYLSGTKSISFVGCATQYFLFLSLGCAECILLTFMSYDRYVAICHPLRYTVLMNRKVGQMMAVTSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYETAVYISDIVLLLLPIILISASYIFILHSVIRMHSAGSKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALRRVLGREMITQNPKVRLP", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A668KLA6-1", "protein_name": "Predicted gene, 52955", "gene_name": "Gm52955", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSSEHCNVSDWLRLEATVKASVYVVAFSITTSLTIVIIAIVSQSLQLRKEVRLVLLCHHLLCISSYCGLGVVFQGMGALLANSPLLLCWLVFGAQLSVGEGILLTLTLMALNTYLAICYPLNSPSFVDSAKYRILAGTWTTVILKNVGLFLIEGTSPTPASVFQSAPLCPVILNGMPARVIGMFSLAFLLSVILVSYCLIYREGKRAGHFNKSNIKARRTVLVHLLQISLHVIPTLIIIGLGKQCGVFFFALNLALFGIFAFAQCFNPLVYGLHNRDLQSKLYPSLCCQKKLLP", "length": 296 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A668KLA7-1", "protein_name": "Predicted gene 7582", "gene_name": "Gm7582", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSSEHCNVSDWLRLEATVKASVYVVAFSITTSLTIVIIAIVSQSLQLRKEVRLVLLCHHLLCISSYCGLGVVFQGMWALLANSPLLLCWLVFGAQLSVGEGILLTLTFMALNTYLAICYPLNSPSFVDSAKYRILAGTWTTVILKNVGLFLIEGTSPTPASVFQSAPLCPVILNGMPARVIGMFSLAFLLSVILVSYCLIYREGKRAGHFNKSNIKARRTVLVHLLQISLHVIPTLIIIGLGKRCGVFFFALNLALFGIFAFAQCFNPLFYGLHNRDVQSKLYPFLCCRKKLLP", "length": 296 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A668KM50-1", "protein_name": "RIKEN cDNA A930007A09 gene", "gene_name": "A930007A09Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSLSELPQKNTDLAEMQSGPLGRCSHFFWLGVAFDAVGVAVLFTGVFANLLFYDMLLYLGSIIIFVSLLWWISWYTGNIEALPEDPLRGTSPRESGVHRSGSRRFSLTLRSVSDTFQRIRRRRRRRLHPRVVQRISSISSTDPGQLERNCDARTSGGRALFRSAKPEAVLNQFSRVQTSKSLPLGIVHTGLSICTSRSQPVFSVTSQTYPLASDSNSQMAMSSDSHVYLDSHSQEHSKISVASQIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVATQIYPLEREESQSHFLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASKIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVATQIYPLEREESQSHFLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASKIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASQIYPLEQEESQSHFLVPMPSDSFPVVPMTSQSQIQGSLAQQSHLQNLPLASQTPETDKASKSHTLAKGVPGVPPGSAQTQHPQASLAQTSQISSPVRKVPKN", "length": 636 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8C2LDI6-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "LOC100774916", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGRLWCKAIFAGYKRGLCKQRGHTALLKIEGVYARAETEFYLGKRYAYVYKEKNNTVTLRCKPNKARVIWGKVTKAHGNSGMVHAKFRSNLPAKVIGHRIRVVLYPSRI", "length": 110 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LMV8-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC100755948", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTNTEGKRRGTRYMFSRPFRKSEVVPLAMYMRIYKKGDIVDIKGMDTVQKGMPHKCYHGKTGRVYNVTKHAVGIIVNKQVKGKILAKRINVQMKHIKHSKSRDSFLKQVKENDQKKKEAKEKGTWVQLKRQPVPPREAHFVRTNGKEPQLLEPISYEFMA", "length": 160 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LSR6-1", "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "LOC100751955", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQDEGEKENPMWELHICKLCLSICVEESRDRLTRAAKVLEQLKGETPVFSKARYTMRSFGIRSNEKIAVQCTVHGTKTEEILEKGLKVQEYELWRNNFTDTGNFGFEIQEHIDLAIKYDPSIRIHGLDFYVVLGRPGFTIADKHRTGCIGAKHRISKEEAMRWFQHKYDGIILPGK", "length": 177 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LUM6-1", "protein_name": "Tubulin alpha-1C chain-like", "gene_name": "LOC100757824", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETDTGKHIPRVVFVDLEPTAIDEVRTGTYRQLFHPEQLITGNEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSRFTSLLMEWLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYPTPLPE", "length": 288 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LZU4-1", "protein_name": "Glia maturation factor", "gene_name": "Gmfg", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDSLAVCEVDPELKEKLRKFRFRKETDNAAIIMKVDKARQMVVLEEEIQNVSPEELRLELPERQPRFVIYSYKYLHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRATDDLTEAWLQEKLAFFG", "length": 142 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2M625-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "LOC100755487", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGYKPVAIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIQTFREHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSSGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALSHEDETIVVGMTNGILSVKHRKSEAKKESLSRRRRPAYRTFVKGKIYMKQRDDIMINRPAKKHLEWYDKDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIVIDIYLPVIGQSPVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMSRNDSVSLSENVPAELPEKTESPCQPGDTDKNS", "length": 527 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2MXE3-1", "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "Gpam", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDESSVTLGTIDVSYLPNSSEYSLGRCKHATEDWGDCGFKTTFFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYILFVQERDVHKGMFATSVTENVLNSSRVQEAIAEVAAEMNPDGSAQQQSKAIQKVKKKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLESQSQKPTSAPLSLEQALLPAILPARPNDAAESEDTSSNEPRNTADEAFRRRLIANLGEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGSGASAGGPGSFISQEQLVRKAASLCYLLSNEGTISLPCQTFHQVCHETVGKFIQYGVLTVAEQDDQEDVSPGLAEQHWDKKLPEPLNWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPETEYLQKLHRYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKRKRVSVLELSGTFLPQCNRQKLLEYILSFVVL", "length": 827 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8D1BQI2-1", "protein_name": "Uncharacterized protein", "gene_name": "LCE5A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSCQQNQQQCQPPPKSLPKYSTPKFPGPCPPLVSSCCGSRSGHGRCYSSGGGGCCLSHHRRRRYHPCQPQSSNCCDSGGGQQSGGSGCSHSSGGSGCCSGGCC", "length": 103 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8D1VKI8-1", "protein_name": "Uncharacterized protein", "gene_name": "NCR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARMLLLILIRVHSGSCALWVSQPPEICTQEGTPAFLPVPSTPARGDWPLALSHGTGTNWPQGRRVVVLGQGVRTGNGTPLVVERGPAQLATPTIFLLRAGFYAFGFLSVAIGSTIYYQGKCHRHMGTHCRSADGL", "length": 136 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5XVN6-1", "protein_name": "SPATA31 domain-containing protein", "gene_name": "LOC689526", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESFLLLMNSAIESWMNTSTMDIATDLSIAILCGVGLFFLLIPFLKDCPLSPASGNKTDIPKDVKRGRSNTRRKTDVEKGCRDGGKTVEETKTPSQPMKILTRQLLQDSTPQIFWNSSQKLDHLLLSQLFSSLTSLEDLILQKFNRRFWGTSSIFSESVVAMAHVLRNPSFPQQKSVRFSDPCVTDQAPSQAQGLRQQHRYHPRLHRQRKTSLVGMTWVPEKKILPISTPKQIHPCLKRRAYGVSCPTTEKGIQTSLPPECLSHKHGLYSKAVKGYVKRNHQKAIGKPPGNWLRDTLKTKAIRPASILSEHLRMFLHHKEPQTKDKATNVEKQQGTCIRSPPSKKLKQFQGRFPPNTDHYCKRRPQLSQPGQPSILNSKSYKLRKIIQSVLAGMTLMKDRADFSMQSQFSQAPQSSVCNAKRYKYSKRMGSVPRRVPLKKDTARYDMGKPIKKCLGAGTKNVPHSACSILGKRLRARNLALKKGQASVMNPTGNYCLHDSKAEMKLASNNTALPVQCRRTPYLQILEALNPIPPGVLASKLPRIVFPSSPICDFKEEYYSKAATVLKNLHHQDPGGTRVKSTSAASLESALSMCSAAKIQKTQRAPPPAASRGLSKAHTDLLKRHLSIQHSALYFEQGRIIQGTGKGSLQQNTNPQKAKHAPLKSFHEGDSRHHSWNGTMVGPGKRVPPAAAKQTKAVEVKKETPYAWSLGSNESHTGKDINISPRVFGSLGAKRSPGHLQTCTPQHSQDSTLRTQGHRNIILCSNKQPQPRPGRHDPECPSTVHPAKVNLSSEHSMSSFQNTCQKPKTAQGSCERADTKENRVLKDKIRINHLKDLCPHKERQGSIRPTAISQGGRLGRSRPCSLSSTQLKDTAKTRTSDKRQATSKSSWKSDIREVLKYGYVGSKDIIGQEDTSKKDQPPAVTERTEEDWTGEKAMCNMIAHLQYLTNFLFEIMEDTEWDPSKLQGCEVESLTFQLGSSSDSSEGDDDINQGTSTSTMSFGQTSPEMHNCSFTKTGIGDKTQSEIKAKTACDQHLNQVNRGMFSDQLPMPKEYDLSCRYRGIQHQQELGLPDQTFYQYKLRMTHCPHGGTKGHNYSFGYRKLGDQQQPDFTHKALDPHQSAKEDMGCVSCLSPKGSRPVKHRRTDCFSP", "length": 1151 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5XWP3-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000063695", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRDMCHMTPYRLLCVLVALALSGCNVAQEVTQVQSTASRQEGEEVTLDCSYETSYVAYYLSWYKQHLSGDIIFLIHQISSSTAEERSGRYSLVFQKSLKSISLVISASQPEDSGKYFCALSDLTQC", "length": 127 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y4M0-1", "protein_name": "Large ribosomal subunit protein uL14", "gene_name": "LOC108350588", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEQRRGGSSGAKFRISLGLQVGAVINRADSTGTKNVYIISVKEIKGRLDRLPAAGVGHMVMATVQKSRPQLRKKVHPAMVIRQQKSCGRKDGVSLYFEEDAEVIVNNKGKMKGSAITGPIAKEHADSWPRIASNAGSTA", "length": 140 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y5C9-1", "protein_name": "Ribosomal protein L32 like 2", "gene_name": "Rpl32l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALRPLMKPKIIQKRTKKFIRHQSDRYVKIKRNWRKPRGINNRVRRRFKGQILVPNIGYGNNKKTKHMLPSCFRKFLVHNVKELEVLLMCSKSYCAEIAHNVSSKNRKAILERAAQLAIRVTNPNDRLCSKENE", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y6V7-1", "protein_name": "UPAR/Ly6 domain-containing protein", "gene_name": "Pate4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNTEPLFDIVINCPIAPQFILKILLFPYPANTNLICNTCNRSENSECKNGTGQCTAPEGGSCSTISIYHGQRHVLSKQMCLGHCEEKPHYNGDFMIYVMCCSKNLCNSF", "length": 110 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y7P1-1", "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1", "gene_name": "ENSRNOG00000069815", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEREKEQFCKLFLGGLSFETTGESLRNYYERWGKLTDCVVMRDPASKRSRGFGFVTFSSMARPHSIDGRVVEPKRAVAREESGDPGAHVTVKKLFVVGIKEDTEVHHFRDYFEEYGKIDTTEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSGQEMQKAQSSRSGRGGNFGFGNSRDGGGNFGPGQGSNFRRGSGGWESSDGYGSGRGFGDGYNGYGGGTGGGNFGGSPGYGEGRGGYGGGGPGYGNQDGSYRGGYDNYGGGNYGKGNYNDFGNHNQQPSNCGPMKSGNFGGSRNMGGPRDEHRSFPSWKGYNGVFGKQSPLTWIKTHSL", "length": 347 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZKP8-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "Gpd1l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGATTLRVCIVGFWSWGSAIAKIIGTNVKNQQKFASTVKMWVSEEAVNGRKLTDIINHYHENVKYLPGHKLPENVVAVANLSEAVQDADLLVFTTPHQFIHKICNEITGRVPKKALGIIHMESIDEGPRGLMLISDIIREKIGMDVSVLMGANTAREVAAGEFCETTIGSKVIQNGILFKELLQTSNFCITVVDDADAVELCGALKHIVAMGTNFCNGLHCGNNSKAAVLRLGLVEMITFTRIFCKSQVSTTTFLESCGFANPITICYRGSDCKEAKTFPRIGKTMGNLQKEVLNGQTLQGLKTSALVYQFLKQKGLLAKFPLFVTVYRICYEGRPSTEILTCLQNHPAHM", "length": 351 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZL63-1", "protein_name": "Ankyrin repeat domain 13a", "gene_name": "Ankrd13a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSDQSRKAAAEGGSSPMVWSRPARAPPGGRADGRGPIVERTTGEGRAGDESRRARTVGFVRGDLGLPKGPAVPQNGGGRVSRRGGLVGRHGAGLGPFRKSGPPPRSVMERLAYFPVRGGSAGSSRFASCQRGRERAGRGVGAAERVPEPVPSPARDPGPPAPPAPDSEALVVRCARHLAARRSPPLALRPVGRAPETPSGGSRLVAGGRSGLGGDLLAMSSARDTSSRFPLHLLVWNNDYRQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSLIFKGGDNWAELMEVNHDDRVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNVAFERTKSGFWGWRTDKAEVVNGYEAKVYSVNNVSVITKIRTEHLTEEEKKRYKEDRNPLESLLGTVEHQFGAQGQDLTTECATVNNPTAITPDEYFDEDFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEERQSVEGTQAECAASDATNFEVDQSVFEIPESYHVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQDLSGPASNGGVSHAHSYEAQYERAIQESLLTNMEGRCPGGLSDSSRFDSDLRLAMELSAKELAEQELRLQEEEAELQQVLQLSLTEK", "length": 809 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZP24-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "ENSRNOG00000064315", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAVPEKEKKVAAVPGTLKKKKVPAVPETLKKKRRNFSELKVRRLRKKFALKTLRKARRKLICEKAKHYHKECRQMYLTEIRMARMARKAGNVYVSAEPTLAFVIRIRGISGVSPKVREVLQLLRLRQILNGTFVKLSKASVKMLRIVEPYIAWGYPNLKSVNELIYKRGYGKIRKKRIALTDNSLMARSLGKFGIICMEDLIHEIYTVGKHFKEANNFLWPLKLSSPRGGMKKKTTHFVEGGDAGNRETR", "length": 251 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZPV0-1", "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "ENSRNOG00000066253", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIVQRIFRLSSVLPSAVSVHLRSNPGVTAVAFNKEPDPVQKLFVDKIREYKTKRQVSGGPVDTGPEYHQDLDREPFKLKQLYGKGEMDKFPTFKFEDPKFVVIDKPQS", "length": 108 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZRI3-1", "protein_name": "Natural killer cell cytotoxicity receptor 3 ligand 1", "gene_name": "Ncr3lg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQSCQRGPENAHMHPKGPCCSALCFLCSLGSSPHGSSLGPLRKCGRRSKPVQSSPEGSRVAEWPDGLLSLLLLLWSLLPSAGGLELEMAGTTQIVFLHEDVTIPCKILGSLHLDLSIVGVIWSLKKDGDESEVFKFYGDQLEAVRPGANVSLLGLEHGDASLYLPRFELWEAGEYQCKVVVTPEKKEGTTRLEVVAHPNMSLSEKPATARGGKEKLIICQLDGFYPEALDIKWMGSALKDSHFQEITEGVVTGPTVKNDDGTFSVTSSLALKPALEDHMYQCVVWHRSWLMPQSLNVTVFENTRDSTHGTVPPTAEVGPPVSEPRSVMIYVTIIGLCILLFSVIVCGLWKWKRLTTSNTGLCLRLDVRC", "length": 371 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZS91-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC134482834", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTETEEELPTPTPKPSISEEGNFHSQYQVLGTSGQGGNGKVLLAHNRLTGTPVAVKVLRKDKQWFQPAMMEANIMRKINHPNIVSLIQVIEKETRIYLIMELVEGQELYQYIRESGHIEEDEARQIFEQILSAVSYCHGKGIVHRDLKLDNIMIDKNKKVKVIDFGLSTQFPPGKMLNHHCGTHSFGSSELLLGHRYDRPKNDMWIIGVVLYCMVVGKLTFDSVIIQDLQRQVVAGVYPAPCGVSKELEDLLSKLLRVNPNFRPTARKAMKHPWFKEHWNGLIVPYEELLPLTPDPAILDAMKSIGLQASVVKHTLKQRKYNEEMATYFFLQKQALQGDGCTAQAQQVSPVAAPFPSLDPAAAFRLEPKRSGSLPVLGTLRVSSSHGHVSHYGQNAHPKGGKRYTVAGRLRPLPMTPTQDHYHKCAVSVPCIQTTSIFSEKSSNKKIKEDNPLSHRAPLEDKPIPSRVRHRGFKGWTRNIANALIKLCCCMPRRKKPRLGQNRISPQK", "length": 509 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZT61-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC134479845", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDITSIKKTLGSQYRVAFFLGQGSYGSVKLAWHRRTQALVAIKTVEISKNTIRAILSEMTTLELLHHPNIISLFQILVTANQIHFILQYAPGGNLVQLISEEGPLPEEKAKKMFGQIVSAIRHCHSLDIVHRDIKPQNILIDGEGNVKLIDFGLAVKCRPGTLLSRHCGTRGFNAPELVLRQPYDGKSSDVWSLGVLLYFITTGYFPFRGNTIDEIEQKITTGTYTVPHHLSGQLENLIHQIFTVSPEMRPSIEEIENHPWIKKCELKIPPMSDPDYKIIEMLCGMGYNAKDILESLQKKRYDEPMGAYLSLKNHVSEGYDLASITPTKPGDPCPPPPPSPAHPSVFGLPLRRRASEPNFGLLHRQPSREQNPLDLILSGLNMGRCVSMPPIAVYYPKKQRSTSTRALHSRPVASPCVYNNMLGVEIILPHKQDIEMNTSSPPQTMGWFKRLRKGIGDCFSRLCCFPRAPKKKTQHRSSKRVAPLKKAASSTI", "length": 493 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZXB5-1", "protein_name": "Uncharacterized protein", "gene_name": "Pilrb2l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TALLSSLPGRNLAMARLLLLLLSAACLHTGNSAGYQEKNDFGVDQPDVLSGVQGGSIEIPFSFYFPWKLAKDPQMSIAWRWKHYHGEFIYTSTRPFIHEHFKGRLIMNWTPGQTSGVLRILNLKENDQATYFSSVFLQTPEGMKLWQSIPGTKLIIHALDTTMRSPSIIPSVVPTDDLEYTQGQRNPSLLNLGAMVGMVMAKVVVIIPLYGWMIFLWWKQR", "length": 221 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZY57-1", "protein_name": "40S ribosomal protein S26", "gene_name": "LOC134478821", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPGPRRPRQEAGSKPRELQQRVLASVKRRCLFSSLGSNTTKKKRNNGRAKKGHGHVQPIRCTNCARCVPKDKAIKMFVIRNILEAAAVRGISEANVFDAYVPPKLYLKLHYCVSCAIHSKVVGNRSCEARKDQTPPPRFRPSGAAPQPPPKPM", "length": 154 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYE5-1", "protein_name": "Oligosaccharyltransferase complex subunit", "gene_name": "Ostcl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METKHSALLRTFPFLVLECPNLKLKKPPWVHMLLAMTMYALVVVSYFFITGGIIYDVSIEPPSVDSMTDEHGHQRPVAFLARRVNGQYIMEGLASSFLFTMGGLGFIILDRSNTPNIPKLSGFLLLFDFVCVLLSFFIARVFMRMKLPDCLMG", "length": 153 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYN2-1", "protein_name": "Non-selective voltage-gated ion channel VDAC2", "gene_name": "AABR07051831.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAECCVLVCPRPMCIPPPYADLGKAARDIFNKGFGLGLVKLDVKTMSCSGGEFSISGSSNTDTGKVSGTLETKYKWCGYALTFTEKWNTNNTLGTEIAIENQICQGLKLTFDTMFSPNTGKKSGKIKSAYKRECINLGYDVDFDFDFGWLAGYQMTFDSAKSKLTRNNFAVCYRTGDFQLHTNVNNGTEFGGSIYQKVLCEDFDTSVNLAWTSGTNCTRFDIIAKYQLDPTASISAKVNNSSLIGVGYAQTLRPGVKLTPSALVYGKSFNAGGHKLGLDLELEV", "length": 284 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYX3-1", "protein_name": "Methyl-CpG binding domain protein 3 like 3", "gene_name": "Mbd3l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LGELGNAGRLTGSMIPSRLQKRRKIQVAKSKRKAKHKSGTTLRNPLRLTSCIFPQPVTVITSYPENKTRYRRDEAKLKKPQQLCALERLKNFQFGGDSKENLSCPLELANAVERIARGMQDEASNQSGDKDQLTSGQVTSDQPPYLETNEHVALQLSPSFSSQGVTLPVPLHLSPSYFLRKVTTGDIQRQAWKVKKARKRLAEALEADRLARQTENMRE", "length": 219 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZZU9-1", "protein_name": "Keratin-associated protein", "gene_name": "ENSRNOG00000070302", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "SPSTCELSSSLHSDCQETCIEPSICQRSCVASSPCQMPCYYPRSSTACSPCQGTYDGSMGVGSNSLKSFGGFTGSLGYGNSGFGSFGFGSCGIRSQGFGCNFHRPGYFSSKSVQSSYYQPGYTSGFC", "length": 127 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZZY5-1", "protein_name": "Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein", "gene_name": "ENSRNOG00000064452", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKIKAVTEESEAQGEGCSQQHRYQELLVYLNPIAQHPGFPPPDLRKIEKGKKKKKRRPTKQKQIRHGVKEVQKFVNKGKKGIMVLTGDTLRGTAIFQLCARTRICPTSIFPLTDLGAAMGSKHPTCVIMVKLHEEYHEAYDKCLEEVQTLATPL", "length": 155 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A2Z7-1", "protein_name": "Developmental pluripotency associated 1, pseudogene 1", "gene_name": "Dppa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMPPQVLISGLLLLLPAAWTTTVTSSDQLWNNHTEVVPTQSPLKISTKDLYIGTSVSAALLILLAGVLAVLKYRHRRKKILESAVVFHGFQNGVFQSTEQSQAVDVYVIEDSKVPVAH", "length": 118 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3D9-1", "protein_name": "Small nuclear ribonucleoprotein Sm D3", "gene_name": "Snrpd3l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIGRPIEVLQEAQGYMVTRETITGEVYPGKLIEAEDNMNCQMSNITVTYRDGPVAQPEQVYICDTKIRFPILPNMLKNAPVLENLKNKNQGSRAGQGKAAILKAQVAARGRGHEMGPWKLPEAKTVFSIKENFPSCLLLGF", "length": 142 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3N0-1", "protein_name": "Uncharacterized protein", "gene_name": "Pramef20-ps2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVQTPPTLEKLAIQSLIRNEDVAMSSLGELPAVLFPALFKEAFTGKHINLVKEVVAAWPFPCLLVGALMKTPNLETLQAVLDGVDMQLTRKFHTRRTKLQVLDLRNMHHYFWNIQAGEEDSSCSAENSKEKKVVKVFHRYALRKRVKVIVELYIHSCLKEEQTCLLKWAQQRKGSLHFCCTKMKVWNLSLCGIGEILKVFDPQHITELELHTEWTLLELAHFAPYFGQMRNLQKAFLAPLHRIMFSNSNGKRDREAKCIKKFISQFSKFNCLQHLHMFCVHFLRDHMNQVLGCLMTPLTLSITYYLISQKDLDSLSRSQSLFQLKHLDLRGVVLCDLDIMPLRGLLEKVADTLETLDLQWCKMTDSQLYALLPALRHCCQLTMVNFYSNNFSVPILKDLMQHIANWSRIRVQQYPAPLECYDDLAQVSVKRFAKLSSELMYTLGVIRQTKNISFATDICHTCGQRCVYHNGSRLCCCWH", "length": 480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3R7-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "LOC120093241", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAARKALTVVAVLGSGAGVGSILFALVTPGELQKQLMLQEMPERDSRRRDAAVRTKELVMATLKDAAATKENVAWRRNWTVRGDGRSA", "length": 89 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3T5-1", "protein_name": "Large ribosomal subunit protein mL62", "gene_name": "Mrpl58", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "EHGGRLGPTLEPEPSWNLVAPAARALCSPDSAQTGERHRVQEHLQPGQAVPRIQGRGYRLEGPGEPRKAGRKGRFLLLLDRLSISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIAEPVRQKIALTHKNKINKAGELVLTSESSRYQFRNLAECLQKIRDMIAKASQVPKEPSKEDAQLQRLRIEKMNRERLRQKRINSTIKTSRRMTMD", "length": 211 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A478-1", "protein_name": "T-cell activation Rho GTPase-activating protein", "gene_name": "LOC134485907", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIHRTLLCQGPVELTSGRKRNKRYLSLFDDVLVVSTNLTKKKFKIKCIIPLNYLWVVDDVELVRANQTCTCKTIFFYWATGNALATFRSKEQKVQWYTFLTRSINEAKKGIKKTFPLHIFPEDIQTCDSSLCVTATNMDTVNDIMEKLLPMIRVHNIEDYQLWFSPGHKETPRALQGHEYPYDIIMNNVQNNLSKSNSKIFTAFPPLPGLFMENQSWDTGGQFILKPRDSAGSQQQDAKERPRKSCMTSCFHGGSVPHHDQECSDPRDDKRGKLFGQDLSSICQDGKLPTIILDMLSRIKDKGPTTDDIFLITPNGSLCKTIKEKLDNGENVDIYQQPVHVVAWILKEFLQSIKGSLLTSKLYDQWLIVPEKVNDKEKLAAVKSLLEKLPKPNADLLRQLFRILHQIKTNSSVNNMSSFRLSLETAPCILWLPSYRNNILTNDIAKKISLVTFMIDNSPELFGEDIVAVWYETSLYHPPGLKYPCSQNTPSSNGIMEETEHGLSSCPGERTCTPDFDELPRSGAAASIPYEGILASEKGEGNESTTQPEPVQNSPTPQTKKELGNCSPNILKDVNVPAVILDMLSVIAEKGQCSDDIFRMQSEKSHWSLKEKVNTGKHVNLKEESVLTVASVVKDFIKNIEGSLLSCDLYENWLSIPDEGPLLGKIASIQNILLKMPKPNYVLLKQLICVLQKIKAASTNQLDTFDLSVRIAPHVLWNPTCKTLFGRDLSKKLSIIKFMIDNCQELFGENDNIFCEDNQKSYDINLSSDTLNTSGKATLMIETIDDHDVKTSKSNTKKLEMSSAVPHEGGPTAGHNGTTSKYNVPQEKILHD", "length": 834 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A4C1-1", "protein_name": "RRM domain-containing protein", "gene_name": "ENSRNOG00000063783", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LTCCAINSDPHPDSGLKMEGHDPKEPEQLRKLFIGGLSFEATDDSLREHFEKWGTLTDCVVMRDPQTKRSRSFSFVTYSCVKEVDAAMCAQPHNVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIKTMEVMEDRLIDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGRGGNFDGRGGYGGGGGGSRGSYVGGDGGYNGFGGDSGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDSYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGRMKRGRFGGRSSGSPYGGGYGSGGGSGGYGSRKF", "length": 350 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A5E5-1", "protein_name": "Paired immunoglobulin-like type 2 receptor alpha", "gene_name": "Pilrb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQILLLLLSATCLHTGNSGGYTRKNYFGVNQPAVLSGVQGGSIEIPFSFYFPWKLAKDPQMSIAWRWKEVHGEFIYQSTLSFIHEHFKDRLILNWTQGQTFGVLRILNLKENDQATYFSQVCLQTTEGMKCWQSIPGTKLIVTHGVICSLLISPQLSYDHEDPLHHHLCRPHSWPGEHKGPKESFTAEPGGHHWDGRGQSCSHHPPLRMDDLSVVEAKASRVTPKPQPE", "length": 230 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A5T5-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "Rpl21l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKGKRRGTRYMFSRPFRNHGVIPLATYIRIYKKGDIVDIKGMGTAQKGMPHKCYHGKTGRAYNVTQHAVGIIVNKQVKGKIPAKRINVRIEHTKHSKSRDGFLKRVKENDQKKKEAKEKGTWVQLKRQPVPPREAHFVRTNGKEPELLERSPYEFMA", "length": 160 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A8T3-1", "protein_name": "Olfactory receptor", "gene_name": "Or1o11b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RMNCSQAPGFILLGLSRDPEKWQLFFSVFLVLYLLGLSGNLLLLLAIGADVHLHTPMYFFLSQLSLVDLCFITTTAPKILQTLWTGDGSISFSGCLTQLYFFAVFADMDNLLLAVMAIDRYAAICHPLLYPLLMTPCRCGVLVSGSWGVAHCVSLTHTLLLSQLYFHTNQMIPHFFCDFGPLLLLSCSDAHLNEGLMMALAGVFGISALLCIVSSYSCIFYAVARVPSAQGKRKALATCSSHLSVVLLFYSTVFTTYLKPPSSSYSSGEVVAAVMYTLVTPTLNPFIYSLRNKDVKSSLRRILNMVKSPD", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A969-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000067430", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFFLFWTFPGLELDKLALLSFESSSSIHPRACASTPAFQRSHNPGDAAQQEAKQREAEMRNSILTRVLDQSAWVRLSDLALVKPDKTKAVEHRVQMARYGQLSGTVSEQGFIETPEKVSQQTEEKATVKFNRREVTDSDEDDDY", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A9H4-1", "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "Art3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQATARGVIKRKAFPGRQLSLSTTSCPGGKITPAESGNRFESGHHLNVLQRHKRQKRKMKMGHFELVTTLLAAMVLMDVFQVQAEVLDMAENVFDDEYLKCNSRMEMKYIPRMHGEELANDELLQSVWDKAGIQWEAQKAQLSLPKNFKDAYGIALTAYVTEAQDQSPFYHTFNRAVKIAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEESYKNVVYSTSPNISFAFGEQNQARLGNFTLAYSAKPQTANEQRLLTIQTCFGVAVGKLLNKESEGIVLIPLSEVFQVSRKGTDDDLILHSINSTCSYYECSFLGGLKAGSCTTNPENPDPGYLNNPDLDSQKLEDSGRKSLDSVKMPEIKVLQGEENPLLPDEKPEDRNRGKANVPTPGLVPVPGPKSHPSSSSGHRLLPSDTASTILLIAAAVDFIAL", "length": 433 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AA84-1", "protein_name": "Ankyrin repeat domain 10", "gene_name": "Ankrd10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLVALCSLLPHTPRAHLAAEDSFYGWTPVHWAAHFGKVGAGTLRRHFPRGVLLGSERTPPCLESAATARSAPPAPPEGSRAHVQQSGLGVKGWGRGGAEAALAPPGVQGACAAARSPGPRGARGVMGGGAEMGSVWPAPRRTQGACAHLWLFRAGRADRMQLRRFARRPSGFGEWCGRLLLEARREPGASRSCLMETGRRAPLRHKGMDAALAAGGVRSAPAVVDGGLAARPTGPLSQLGPPCLECLIQLVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVGNGAQTDLRNASGLTAADIAQTQGFQECTQFLLSLQNHQMSRFCPNGTLSGGHENILPNHINLGTNRKRCLEDSESLGVKKARTRVPSLDHTMPLANGDAEDDADRMHVDREFAAVSDMKNSSSVLNTLTNGSVINGHLDFPCVAQLNGMESRSDPCLTGSNGISNGQPFPSGQGPVCANGTEEPEKTMGVNPEMCGSLHLNGSPSSCVASRPSWVGDIGESLHYGHYHGFGDTAESIPELSSVLEHSSCVRVEQRYDSAVLGAMQLHHGS", "length": 621 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ABF4-1", "protein_name": "Nuclear transport factor 2", "gene_name": "AABR07018058.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDKPIWEQIGSSFIQNYYPLFDNDRTQLGAIYIGASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSIMAQQYQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNSS", "length": 127 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC04-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMLSQNKTLKSIEEVALHVILLCQVGVGTVANFLLFIHNFSVILTNCQLTPIQVIVTNLAVASAFNLLLLAFPNNVTLFVPRKAPSDLSCKLWYFICLVARSTNLSSTCVLSTYQFVMLLPGNWSRVILKGRAPKIVNYSCYGCWIFSVLNNAYIPVKVSGPQKTQNDTDFKDKWVCSTSGFSVGMSFLRFAHDALFISIMIWTNVSMVILLNRHHHRLQHIHSSNQDHRAYADTRAAHTILMLVVTFLSFYLLDCICTFFHISFVDSRLLLRRIKEVLTASFPTISPFLLIFRGPKNPCSLLSRS", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC51-1", "protein_name": "Non-histone chromosomal protein HMG-17", "gene_name": "Hmgn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKDANNPAENGDAKTDQAQKADGAGDAK", "length": 90 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC66-1", "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "Eif6-ps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVVRASFENNCEVSCFARLTNTYSLVAIGGSENFYSVFEGELSDTIPVVHASIASCRIIGRGTSVWGTGMGYWYPTTTTDQELQHIHDSLLDSVQIRRVEEGLSALDNVTTCNDYVALVHPDLDRETEEILAGVLKVEVLTVADQVLVGSYCVFSNQGGLVYPKTSIEDQDELSSPLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDRLT", "length": 245 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ACC5-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000069094", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LPLLAFEKYVVCDGELQRLQVSCEVLGDVDPPQRLSASVVQMKQSVVEFLGTLVEQDAQGAAEDMDNALVGDNEEAEGENNSTRTNSDGPFTERPNQRLNNR", "length": 102 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AEL7-1", "protein_name": "Protein phosphatase 4 regulatory subunit 3C like 1", "gene_name": "Ppp4r3cl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDKLYRVKVYVMMEDKQWKDIGAGQISSKYIDRLQGVCLLVHSESDGSPILECKIQPNVPYQKHQGKVIIWSEAKNHGTAIHFQEPNDCQETWEVICQVQGKDPNVEITQLLTDDLESFKDMLLSWNKVEMSSCELHTLENIADLLSFVNEAPSHKKILTLVLEKEGYIKKLLQLFKTCEKHQNIDGLHYLNNIIRGILFLDNIHLFNIMFSDEFIMDVVGCLEYGPGLDEPKQHRQFLTQNVKFKNVMQITHSQLRKKIQQTYRMQYIYDIVLPTPSIFEVNLLHDLSTMIFFNKIEIITMLQEDEHFLLEVLAQLKDNTVSNERRHELLLFFKEFCAFAKTLHFQKKNTLLKTLIKLGIISALKVVVHMHDYQIQVAALELFAHLVEYSPRLIRAYAMKEAQYSEDNDGLLINIMIKQMTCDSDPEFSRSIILTTVLHAILDPENMRVTTKGHERRKFLNYFYRHCMNKLIEPILSITVENNSDDNRVNICPDNYQNAQLLGAILEILTFCVQYHSKYVKNYIISKNLLSRILILMSSKHTFLILCAVRFMRKMIGLKDKMYNLYIVEKNLFEPVVNAFMHNGHRYNMLNSAIIELFEFIRQENIKSLIANIVEKFFMFFESIQYVQTFKGLKTKYEEEKKKKRERQLRKSLHNIIYQRIYCRHIKAMEVKVKADIFCRQITDKEEEREKGGGGGEGGGGRGGEGEGGREGGGREGEGGGGGKGGRGEGGAVLSMGSDIPSHYDMFVKINEMNERENVIECRKRKSSATSEYSTSCGDTSDNGISTVYCSSLVPLVDYAYDTDGEDDDGSYGNNENEEEEEEEEEEEPPKKKPYFHP", "length": 840 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AFG0-1", "protein_name": "Cytochrome b5", "gene_name": "ENSRNOG00000064959", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFAKEKGKFEDMAKDVKCYTLGEIQKHQDIKNSWAMLHHRVYDLTKFLEEHLGEEEVLRERAGGHASENFEDVGCSTNVQGLSKVHIIGLFHPALITTIKLNSNWWDQLCSPTSQVVVAHTFNPSTREVGAVGFP", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AGM4-1", "protein_name": "Proline rich 18", "gene_name": "Prr18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRLLGRVMSFSPMPPPPPPPPPPARTQGGPAARQLSRRPCGPPAASPPAPAAAAAGEKKRRPPEMLLSSSWPSATLKRPPARRGPGLGPGTPQPPTSARVPPQPSPGRGGTSATCSAPRRIACSHIPAGSTASGTSAGAGAGPEDATRFSLSLTPEAILVIQRRHLEKQLLARPRRPFPAPSADPRRPLVPCPRTRSSTLRRGGPTSVPDAPLAVAVSSRPPRASLLPGGLQATMPSPRPSSLRPVLKVSLLNEKHKYDDEEYEEEVEVVDEGLVRKCTEWLRGVESAAAARGRTGHLDSLPHLSTL", "length": 308 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AGS9-1", "protein_name": "Olfactory receptor", "gene_name": "Or5aq7b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVWNSTGVKEFILIGLTENPNWQVPLFLLFCIIYFIILVGNCGMIFLIWLNVQLHTPMYFFLSNLSFCDICYSTIIAPKMIINFLSEHKSTRLFACILQSFFFAVYATTEVVLLSMMAYDRYVAIANPLMYTVIMTQSICTQMILASYLTGLINSLIHTIGLLKLNFCGPNIVNHFFCDVPPLLKLACSDSHINEILLLVFSGIIAISTLIIVIVSYIHIIIAILRIRSAMGRGKAFSTCASHLTAVALFYGSLTFSYIQPSSQYSMEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKEAAQKLMLGKRNAC", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AIA3-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000065493", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIFVPFFPHPGSIRKDGVVYAHTMENSSNSPRETREPAPLRRTWRGCFQRALPRVSKFFRRGRGSTGGWDNGSPRQGPMHSDQDLRHLRSLLSKESCPVMSK", "length": 102 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AK52-1", "protein_name": "Olfactory receptor", "gene_name": "Or9s14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIEVHRNGSLSAMSLQGFVLLGFRGGAETQALLFTVFLVLYVVTVLGNLTMIMVITLDARLHSPMYFFLKNLSFVDLCLSTVVVPNALASIFFSSKTISFAGCATQFFFFSLLAATEAVLLAVMAYDRFMAICSPLRYPVTMCPMTCVRLVLGTFCVACLNSIVQTSLTFRLPFCSSNRIDHFYCDVPPLLQLACASTALNELVMFGICGFIIVCAVFVVIISYVYITVTILRMHSGSGRHKLFSTCGSHMTAVSLFYGTGFAVYGQPGGVASMEQGKVVSIIYILIIPMLNPLIYSLRNKDVKDALRRLGQRHSLAKESG", "length": 322 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMC4-1", "protein_name": "Retinoic acid early-inducible protein 1 domain-containing protein", "gene_name": "ENSRNOG00000068014", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCVFKNAWGHRNMCSMALCSQFGTHLHVSLTDAHSLSCNLIIRSPTKAEPLRYEGHCSMDEIVFLSFNNVNKTMPLGNQEKMANATKVQKCLTQWIDLLGQDLRDKVSEIKVHTTKTSGHPTLRVTMLSKHRHGEIIGASWEFNISENYSFILDLKTMKWKPQDIMKEWKDDETLMKHLNLSIVECSQKFNEFLNQHEERTSRYYLDSALPPAPPPLFKGFTILLWHSYTPAISPTSSDTHSSFINFRDGLIDINFPL", "length": 258 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMN7-1", "protein_name": "60S ribosomal protein L7a", "gene_name": "ENSRNOG00000070681", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPGYITLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLACAEKKAAGKGDVSTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVLYCIIKGKARLGRLVHRKTCTTVVFTQVNSEDKGALAKLVGAIRTNYNDRYNEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMX9-1", "protein_name": "Ribosomal biogenesis factor", "gene_name": "Rbis", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKNKLKGQKSRNVFHIASHKPLKAKNKAKPVTTNLKKINIMNHEKVNRMNRAFVNIQKELANFSKSLSLKSVQKELHHEKEPANVDEATRLMAQL", "length": 96 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ARJ3-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "Or8b101l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLGNVSSVKEFILLGLTQQPELQLPLFFLFLGIYVVSVVGNLGLIVLIVLNPHLHTPMYYFLFNLSFTDLCYSTVITPRMLVGFVKQNIISHAECMTQLFSFCFFVIDECYILTAMAYDRYAAICKPLLYQVTMSHQICLLMTVGVYMMGFVGAMAHTGSMLSLTFCEGNIINHYMCDIPPLQKLSCTSTSINELVVFTVVGVNVIIPTLTLFVSYTLILSNILSIHSAEGRSKAFSTCGSYIIAVSIFFGAVLFMYFKPSSASVDGDKVSTIFYTILGPMLNPFIYSIRNKDVHVALRRTLKKRIFT", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ATM0-1", "protein_name": "ELAV-like protein", "gene_name": "Elavl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDAGAGSCRYKGLGAAAVRPRARSAQRGPVGGREGGREERTHYPAPDRPDRGPAAEGRAAEISVGKSDFCGPRGAALRAPSTARPLPPSTCRQGSGRRSAHPQARVSSRPSRAPPPPSSPLRRPQSQTPGRDPGVSTRRPPRSARPPEPPSIRTAPAGHTRMVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKRFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 522 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AUS4-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "ENSRNOG00000062467", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQTAAGKTLAVVAVLGAGAGVGSILFALVTPGELQKQSMLQEMPERDSRRRNEAVRTKELVIATLKDAAATKGNVAWRRTGQLEGQGRMCGTKGTNKCSLPIKWISQLDI", "length": 110 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AWY6-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000065059", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKATKKSKNTTSDVEPSTSSAKSKKAKTCYQYQTRAGEKKSRWSGSDCSVNVQKTTKKAKRTLPRIAENNTSEKTVPPTKKTKRAKDEQLFGHYHRLMDEISTSTERGPEQSSTDSSSASTSDEESQ", "length": 128 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6B5G4-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "Ptp4a1l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARMNCPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCKATHDTTLVEKESIHVLEWHFDDGAPPSNQIVDDWLSLVKIKFPEEPGCRIAVRCVAGLGRAPGLVALALIEGGMNYEDAVQFIRQKRRGAFNGQQRLPLEKYHPKMWLRFKDSNSHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6B646-1", "protein_name": "Ankyrin repeat domain 66", "gene_name": "Ankrd66", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSREARLHHQTPGDQEAGAACLLSWGGGGASFHGVNTLTLRPAMMACSTELLKDTDSVMELSKLSDMTKLHQAVAAGDYNSVKKILKKGLCDPNYKDVDWNDRTPLHWAAIRGQMEVIHLLIQYGARPCLVTDVGWTAAHFAAESGHLNVLKTLHALHAAIDAADFFGDTPKRIAQIYGQKDCVDFLDTAEPECRDHRQRGLLFDERDPDWDLKKRELELSLPVPDQNTNKKKKRIRGSTRVNHSKAWRI", "length": 251 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G1V0-1", "protein_name": "Ankyrin repeat domain 62 like", "gene_name": "Ankrd62l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRVAGLSSKKSRWLLQSLLDQQRHSLGTGFESANILLSPKYHLKDKDLRKIHKAARDGDAARVQQLLLGKHCVNDKDKKKRTALHIACAYGHPKVVMALVEGKCEVNATDSEECTSLVKAVQCQEEECATILLENNADPNIVDAQGNSALHYAVYYKNTSLAAKLLDHEVNIEATNKDGFTPFLLAVSENKLKIAKFLLMKNASIHAADNQKRTALMHAVSHDSTNLVRFVLEQGVDLFVKDAFGLTAIDYAADFKYNSNMEILLEYKAKRYEESERANLVEKSSEEDSSRRKDQQSQELENMEKEELTEPGNGTEEQEPDGGVTSVEEPRRLDDRGDDQPQEAVTAPRTREKEQELPFTDMCTVVTGKEDEDESSWDSESVSENLPLIRIGVDGLLLVNGQAVENPEKYLHWLHNRKGEESVPNETKGVGDLQAFTPAEPGLELTSEEKHEELSRNEDCQPQVEEERTQEWSGWGAPEALCAAALDHGDIGSPLTRENGHPRARQSPSVDSEEQDGGSGLNIKEEKTRDHEEWSGDFLMDRTSKESEPAAGDLLQVKDSWSLNDTDPNKGSPAKRKSKEKHKVRGEMNAMEDADDFTPLSESCSDNKAELCCNTHQAETETESCELLTRQTGNMEGGVAGEVLKTEPARSREALKETEETGEGARVKMQLPGKDELYSEDAERQQYDMALSALHLKTKQTVRQLQETQDRQREVVRSSQRMQDHLQKLQAGCSEAEAMVQEQGKKTAELQKLHAGMIHELKEKWETIASKYLPLNIQLKYLEQELLSIKIAQKQYEKLHEDQRTLQRDAVDLQHQVQENMAKLDDEKQAMALRDSNNDSLMSQVELRIKNLESNLQKLQAEKESNERNVEKYLQRYIRERELSKTLSHTLHRTNSKLSRVRTDILLVTERNRTVQNTLTTRPVPKSPGVTEHSAYVNRNPNFIASRNLEAAMSSPQPSPELMRRRLLKKQKNMVKNITEEVDKAAAELESWSLEAYPSGSK", "length": 1003 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G430-1", "protein_name": "Large ribosomal subunit protein eL24", "gene_name": "LOC689816", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLETCRNLSAIGYIWEDNSTEEYCKSSRRHGRPTSVTMKVNLCSFSGYKIYSGHERLYARTDGKFSSFLMPNVSPHSFPKGTLGKLTGLSSTEENTRKDSRKKFKRKEPTLQKFQRAITGASLADIMAKRNQKPEVRKAQQEQAIRDAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR", "length": 193 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G808-1", "protein_name": "Paired immunoglobulin-like type 2 receptor beta", "gene_name": "Pilrb2l7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARILLLLLSAACLHTGNSAGYPKKYDYGVDQPAVLSGVQSGSIEIPFSFYFPWELAKDPQMRIAWRWKVFHGEFIYNSTQPFIHEHFKGRLIMNWTQGQTSGVLRILNLKENDQATYFSRVFLRTTEGMKSWQSIPGTQLIIHALITTPGSPSIIPSAVPTTGLEDTRGQRTPSLLNLGAMVGMVVSKVVVIIPLYGWVIFLWWKQRTQFRRDLVSEHPWKNFVPILPAESSSFL", "length": 236 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GB91-1", "protein_name": "Olfactory receptor", "gene_name": "Or4c117b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TNRYYFNIFMIIMQNQSFVTEFILLGLSQNPNVENILCVVFLFIYLATIGGNMIIVVTIIYSPALLGSPMYFFLIFLSLLDACTSSTVTPKMIVDFFYERKTISFECCMTQLFAIHFFTGIEVIILSAMAYDRYVAICKPLHYSSIMTQRLCGILVIVSWAGGFLHSIIQIIFTLQLPFCGPNVIDHYLCDLFPLLKLACTEPHIFVILVFSNSGSISIIIFSILLVSYGIILFSLRAHSSEGRRKALSTCGSHITVVLLFFVPCFLIYARPTSAFSSEKNAFVFATIITPLLNPMVYTFRNKEMKNAIRKMWKRLIMVSCNY", "length": 323 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GF85-1", "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "ENSRNOG00000064148", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "HFFLEYLNNLKIMLIFLSPPTGGWASDHHSPTTGTHLRFLNSLGAAFSFISKEVVSKLQIMEHPRSSPQSEHCSSLQSMAAYEVSNKLLDLARRSGPLHSNSGCRTVLCLHRALHWLQLFLEGLRTSSEDARTSTLCTEAYSAMLCAYHSWIRQAVTVAFCALPSGKVFLEMLGEALPFMEQMCDISQFYVEHFLLDLP", "length": 199 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GFV7-1", "protein_name": "Olfactory receptor", "gene_name": "Or1f21c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLTMYLATVLGNLLIILAISTDARLHTPMYFFIMILSFTDVCFSSTTVPKVLANYMLRSQTISFSGCLTHLYFLCVFADMDNFLLAVMAYDRFVAICHPLHYTTKMTNKFCVLLIVGSWVLTNLNALLHTLLMAQLSFCGDNIIPHFFCDATPLLKLSCSDTHLNDLMILTEGTMIVVTPFFCILISYIHITCAVLRVSSPRGGWKAFSTCVSHLAVVCLFYGTIISLYFNPSSSHFAGKDMAGAIMYTVVTPMLNPFIYSLRNRNMKGVLRKVLILRFPSKQ", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GGC1-1", "protein_name": "Histocompatibility 60b like 1", "gene_name": "H60bl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKGATSKCNHSLTLSLLVLLNSLGTMQVDGTDSLSCNFTVQYKVSLGQCSVNGMTVLCFDDVRQNSPVCKTEKKGNATKLCNDLNQCLSYSFYEMMKLESGLFESKGNHTLRVTVQSQYNQGEFMDGCWAFMIDRQYPFYFYPKNMTWRENQPNAIKTMSQWENNRELFQSLKFLSTGDFSLCLKKLLTDSRELTRSTIKAPDTTQPTSTTQSPSTGNSTPAMSSNQSPSTGNSTQPTSTTDYLIVFEFTAIFLALIVVSMEKKKVLPAAPLPLQYELQSPSPAVLEES", "length": 290 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GIM2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x11c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADLFNVTEFIFLGLSPNKEVQRVCFVLFLLLYMAIVLGNLLMVVTVAVSRNLGSPMYFFLSSLSFVEICYSSTTAPKLILDLLAEMKSISVWGCMTQLFFLHYFGGIEIFLLTVMAYDRYVAICKPLHYTSIMNRKVCIVLVGTAWTGGFVHSFAQIVLIFPLPFCGPNTIDHYFCDVLPLLKLACSDTFLIGLLIVANAGTLSVIIFVVLLASYVVILFHLRTLSAEGRRKALSTCGSHVTVVILFFGPCVFIYSRRSDTLPVDKMIAVFYTVITPLLNPLIYSLRSAEVKKAMKNLWFRTMKADEK", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GJN1-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "Hnrnpa1-ps20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LSQSPPRNRTEQLWKLFIDGLSFETTDESLRSHFERWGTLTDCVVMRDPNTKRPRGFGFVTYTTVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGSIKEDTEEHHLREYFEQYGKIEVIEIMTDRGSGQKRGFVFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRNGSGNFGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGSRSSGSYGGGGQYFANPRNQGGYGGSSSSSSYGSGRRF", "length": 319 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GJR0-1", "protein_name": "Aspartate aminotransferase", "gene_name": "Got2-ps6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLHSRMATTFHPGLAAAASARASSWWTHVEMGPPDPILGVAEAFKRDTNSKKMNLGVCAYRDDNGKPYMIPSIRRQRPRLLEKIWTKNAYPSGDWLVFVRLLQRSEPVFCKDILSLAKMSFYPNHPGETTRPSSGMPACSYKVIDTMTHKTCGFDFSGALEDISRIPEQSVLLLHACAHNPMGVDPRPEKWKEMVSVVKKKSLFAFFDMAYQGFASGDGDKDAWAVQHFIEQGINVCLCQSYAKNMGLYGERVGSFTVVCKDEEEAKRVESQLKILIRPLYSSPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISKRTQLISNLKKEGLFHNWQHITDQIGMFFYMIKDGRISVAGVTSGNVCYLTHAIHQVTK", "length": 379 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GL73-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC134481331", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TALLVSLPEQNLAMARILLLFLSAACLHTGNSSGYRRVNDFGVNQPAVLSGVQSGSIEIPFSFYFPWELANDRSMSIAWIWKYFHGEVIYNSTQPFLHEHFKGRLIMNWTQGQTSGVLRILNLKENDQARYFSRVFLRTTEGMKSWQSIPGTQLIIHALNTTMGSPSIIPSAVPTAGLEDKRGQRNPSLLNLGVMVGMVLAKVVVIIPLYGWMIFLWWKQR", "length": 221 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GLF3-1", "protein_name": "Heat shock protein 90 alpha family class B member 1, pseudogene 13", "gene_name": "Hsp90ab1-ps13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESQTDPSKLDSGKELKIDIIPNPQERMLTLVDTGIGMTKADLINNLGTIAKSEDQTEYLEERRVKEVVEKHLQFIGYPITLYLEKEREKEISADEAEEEKREKEEEDKEDEEKPKIEDVGSDEEDESSKDKKKKTKTIKEKSIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNAWEDHLAMTSLSGYVSRMKETQKPIYYISGESKEQVANSAFVERVWKRGFEVVNMTEPIDDYCVQQLKEFNGKSLVSVTKEGLELPEDEEEKKKMEESQTKFENLCKLMKEILDKKVEKVTIPSRLVSSPCCIVTSTCGWTANMERIMKARALRDNSTMEYVMAKKHLDINPDHPMVETLRQKAEADTNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNCIYCMIKLGLGIDEDEVTAEELSAAVREEIPPWRVMRMPLAWKKWIKGSWEAPALCIVSLGLPQQP", "length": 518 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GM54-1", "protein_name": "MAGE domain-containing protein", "gene_name": "Mageb11l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPHDQKSKLHSRENSYQAGGGAQAYGDAEEIAEAAAEAAEESSAKSQSQPGAEYSRNHRAPPKAKPSAKLILSSSSSESDESSHEESEPSVQKDRPFLHQDLIERRVAILLQYLLHNYNLKQLTTKEEMLKVITKKYEKDFPEILRKASEKLEDAFAVEVREVSSSQPSYDLISKLKLPNNGRIRAGKGLPKTGFLMSILGIIFIQGNSASEEDIWKILKKKRIYPGKKHRVFGEPRKLMTQYLVKLKYLEYRQVAHSDPPRYEFLWGPQAHAETSKMKVLEYLAKINKTTPHAISALYQEALKDEKERAEVRDEDNTDTTDQSTEGSPEKSPTASTTPVDT", "length": 342 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8J8YII4-1", "protein_name": "Coiled-coil domain containing 188", "gene_name": "Ccdc188", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGPEPLGPCGHSHTQHPPAPVSNNHGGCLNQPCQGFVRWPCLVPLQSTQSLESSRPFPAPGTGSGGPRMRGEAPGMFLSSEGEIPRQRAREPAGARQEEVEVEWDWPLHPGHEQGPPRQTAPPTSGPRPCPCPTLPPRGRATASSRQAPTQLQGGTLESAQQSFLQLEQENHSLKRQNQDLREQLGALLGPGQQFLPLCSEHSSCTALAWVSGNTRSRTHAAAPPAVHSLGPDPGALPQSPESARTRLLEDRAPVQLLRQQELCPGKESFVRQSQSELQQIRLSFERKKMAITEVWDGVAEVHMALNNQATGLLNLKKDIRGVLEQMEDIQLEILGERAQCRTQARKQQQMMEAAGLEAAAGCSAGLHSGLRVRGGPHTLRGAGATPAEPSQRLEAQGLTGSLLTPGGGRLPAFLEQKPSGPSKEARWLVLPQGLRGLTGPCLQHCGTWPLPEAAEKGGGRASPEGWACSWIYSHDTLCM", "length": 481 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9PVG7-1", "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "htr7a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLGDTNRTIIAKSHGETMKSLMAEERARETGASVETFNGIMISEVLVPRLFKIAHESGEVAVAAGSGSMDMKPSSSPILLEMMEVANGTRCAEQILSYGEVEKVLIGGVLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSITDLIGGRWIFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLSVWLLSASITLPPLFGWAQNVNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRAAKLSAAKHTITGFPRVEQEEVEEDEVEEDGGDGAEEPTGVDCVTVAIKLQREVEECARLPRILRGVGRRCSDRRSISIFKREQKAAATLGIVVGAFTICWLPFFLLSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLSCRYRNINRRLSAAGMHEALRLVERPEVVVSG", "length": 479 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M9QGZ8-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr118", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLFTVLGVIALFLRERDTNNTEEEVQNDVPPVRNSDGQEIDDWCKEPSLLEPVSVHSEEPSLEEPVSAHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLVEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLKEPVSVHSEEPSLVEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLEEPSLDLSFFSAESSWSEDLSSSFLTVESSWSDDLSSGFLTAESGCGDDEPLFVDSAEPEKLKEDKETQIIEINSHCYAIEAQLGEGGCGAVFSATRLEDGLQVAVKLSDFEEEKRFISVDGFEDPLPLEIALHFLANKGPKVKEIIELLDWKVEADRYFMVLEQPIPCMSLHEFLLDCEGIIPENKLRTIMYQTTVAAQTCCQRGVLHRDIKLENLLINPDTLEVKLIDFGCGDLLTEDSFQYFRGTREYFPPEFSSTGRYHGEPATVWSLGVVLFLLVFYRFPEQSDLPRMNNRRLRIKGLSRDCCDFFHGCLQLDPKDRLELQNLSSHKWIRTRTRRNDENCPNLTDGSSHSNHPITSN", "length": 567 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0WZU8-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR6B2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPMVVNLILGWWLVAVSRAQKLPRPSLSLHPSQGASLGDNVTLRCHLPQPAAWVRLYRYQNPTYIEQKDNVQDMAEFSLTSIKQEDAVIYQCQYQGLAPAGTSQKSDPMELLVTDHRYPPPGISLSPKEHVEMGSNITIQCWNKDYGASFLLHKGGHSAPIQHQEPDYWGTATFTLFGVTPADSGTYRCSYRIGGCCLLFSPLGDNVTLEVIPRPAPPGVNGGPSRNLVAAVAGGCAAAIVIITVSFLLVALRRQMQRAERPGATPRSPEAVQFQVSPGDSEGLTYAQLQAVTPSTHPPTSSTTPEPPIIYAEVGTRGPR", "length": 321 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XEA0-1", "protein_name": "C-type lectin like 8, MHCY region", "gene_name": "YLEC8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTSSDPQLPEEDVQILLLESNTSTPAMGEGDQQETFSEHQAAPEPLGQSGGHQWGSWCHGMGRRRSCVQLIAVHAALGALILMLVVLVISTVCRRAPIPPFSAFGHACPNAWVGFQGKCYYFSKEENDWNSSREHCSAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKVHPQ", "length": 276 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XED4-1", "protein_name": "C-type lectin like 18, MHCY region", "gene_name": "YLEC50", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTSSDPQLPEEDVQILLLESNTSTPAMGEGDQQETFSEHQAAPEPLGQSGGHQWGSWCHGMGRRRSCVQLIAVHAALGALILMLVVLVISTVCRRAPIPPFSAFGHACPNAWVGFQGKCYYLSKEENDWNSSREHCSAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKAHPQ", "length": 276 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XEJ6-1", "protein_name": "Sulfotransferase", "gene_name": "LOC769841", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVCRAAAPNSHPSTMPVHYVTYKGIKFPPAYNSVHSLSFAHNEFLVRDDDVFNITYPKSGTVWMTEILSLIRSHGHPSWNQTVLNSDRMPWFSTRLGLEAALSYPSPRLLTCHLPRHIFPKSFSHSTAKVIYTLRDPRDVVVSYFYFCKMCNSYEDPVSFEQFLRDFLSGELPHGSWFEHVRGWMQMKDRENFFFITYEELKQDLQGSVRRLCHFLGQNLDDDAISSVVQNASFMAMRQNPMCSSILLPADIMDQTKGQFLRKGICGDWKNHFTVAQTETFNRIYLEKMRGLNVAFPWDRDQDPDLTEQ", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XGU1-1", "protein_name": "C-type lectin domain-containing protein", "gene_name": "YLEC62", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTGSDPQLPEEDVHISVLESNTSTPAMGEGDQQETFLEHKAVTEPLGQSGEKPQWGSRCHGTGRRRSRVQLIAVHAAVGALILMLVVLVISTVCRRASIPPFSAFGHACPNAWVGFQGKCYYFSKEENDWNSSREHCNAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKVHPQ", "length": 277 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XGW1-1", "protein_name": "NHL repeat-containing protein 3", "gene_name": "NHLRC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPAVLWRLQRLSAAERLEARLSGAVRKEPGRGEARQSEKKPHSPHCPLRCSYACPGRTPMTSESGRKALSHLGRQQQCLNKMAELRARLEAFPAPECLFKTLNPFMGFLRLFFAPQPLGGEQALFRAAQCAEASPRIPAPQAWAGRSRGCHGNAARPASMGRKQAVGPRLVMAGALLTLLGLLWGSQMLKAFDYFSSWKGDGEQQMYKLDISWPKIPEYFSGQTFCVAVDSLHGLVYVGQRGDDIPKVLVFSVEGYFLYSWNDTVEMPHGIFVLNTATDSSVWITDVGSGKYGHTVKQYSPSGKLLQVLGTPGNAGSSLNPLQFDQPAEIFVEESGEMYIVDGDGGMNNRLLKLSQDYKEIWLSGENGTGIGQFKIPHSVTVDPFGRVWVADRDNRRIQVFDKVTGEWLGAWSSCFLEDGPYSVRFTGNYKYLIVAHLNINRLAILAAPPVGEIGDCAIVSTIQLADETKPHLVDVDVKSGAIYIAEIGAQQVQRFVPLS", "length": 502 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XPN1-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR2A13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPMAVALILGWWLVAASRAQQLPRPSLSLHPSQGVSLGDNVTLRCHLPRPAAWVWLYLEGRWSYAKYIDKKQDTTEFSFLSASHDQAGTYLCQYQVSESEDVSVTSDPVKLVLTDRSFPPPHISLHPEERVGTGTNVTICCWNKDYGATFLLHKDGRSDPIQRLVPDDVGAVSFTLFGVTPADSGTYRCSYHPKNYPFLSSPLGDSVTLEVTPTPAPPGAELVSRGNLVVAVVRGCAAALIFGLGVFFVIDARSLWIRRDESLGGEGI", "length": 269 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XPP6-1", "protein_name": "SUN domain-containing protein", "gene_name": "LOC776146", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQQGHGERGNWQTKVWKTVALVLVTVAVASFGVYCVGGLVEGIKTTAGVTARLVRRDGEIVSLDEELAKVQRQLHVLQWRARDITERALHEALRRTELPGFTGEAVQKIIHQVLEKLEESPFQMTNYASKTSGAAIVRSKTSPSWIGSGRVFWQSLPLVAYMRPPEVILEPDNHPGNCWPFPGSQGHVFIKLPVAVFPTAVTINHGVPAAAYHADSISSAPKDFAVYGLQEEDDETGTLLGEFIFMPGQAPGQTFQLKNEHSAFIKYVRLQVLSNWGHPEYTCVYQFRLHGDPAPDGDARGKLSA", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XQE0-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR6A8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPMAVNLILGWWLVAGSRAQQLPRPSLSLHPSRGVSLGNLVTLRCHLPRLAAWVWLYRGGGWSYKKGKKKEQDAAEFSFASTLREHAGRYRCQYRVYESAEVSVESDPVELVLTDVRYPPSSISLQPEQHVGTGTSVTIHCWNKDYGATFFLHKDGSSDPLQRQDSSGGGTATFTLFGVTPADSGTYRCSYRHWRYAFMSSPLGDSVMLEVTPTPAPPGAELVSRGNLVVAVVRGCAAVLIFALGVFFVIDARSLWIGRDESLGGKGI", "length": 269 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XTD2-1", "protein_name": "Coiled-coil domain containing 97", "gene_name": "CCDC97", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKEDPKEAEGPTASKWIPIASNGNPTASKWIPIASNGDPTAPKWVPISSNGDPNWVPISSNRDPMASKWIPVSSDRDPTVTKENPPSSNETPAAEWDPKVPPEGRPVEEGDPKASPTEDPPAEPDPKASNCAPLSSHWAPEAAVWDPTSPHRDPTAEPQCSASPEQHRAAQRDPASPMEEDRYPATHGVRPATRADPAPYGDHPEAEEDPLPAAVEAMLAAVAASPVRVRSQQQGDPELTAAERRRDLRALFLRKPLVFLERFHGALQAEHLPCFAHLPPRYEVAFYCRQVRARRQQNPQTGLSRWPRRPGARTRLRNRRYAALRQLIAGGEYFSEEEMRAREPLLYEHYIGQYRDAETPPGTPPCPPHPGTPPGTTWAAALLRSVEEAAVQQRLQRQRLREGDSGEEDEDEDEAEEPHIPDAGELEVLREEFRSRMYQRFLDGEDRDFDYSQVDENPDMDNLDIESRDAEERYFDEEEPSAAPQLE", "length": 487 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0Y889-1", "protein_name": "Transmembrane protein 65", "gene_name": "TMEM65", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAWLGRAVLLLGRPGGPAAPSSSSRLCSLRGPPRCCCRRRLSSLRGGADGLLPARGAPPGRALGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLRELHRFESIAIAQDPIAARASCQQYGETWAHQEPSGACSSVHSQAYHQKEAVPSSNCPSTKYDRTHYLWPPLMAEAAGKPGRCPHCCAEGWSSEKLEVAPPSPGQLRHVFFHNALPFVGFGFLDNAIMIAAGTQIELSIGVVLGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQADMWQTRLSAHLGKAIGVTVGCILGMFPLLFFGDEEEKLEEKN", "length": 328 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0YA34-1", "protein_name": "SWIM-type domain-containing protein", "gene_name": "LOC100859602", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAERGQLPPYAKRLCCRPGYGSGCRLGQQAGDTGPGSGTFCAGPSSAAAAAAAAAAATAASLVLLPLGKTQSPESLLDIAARKVAEKWPFQRVEEQFERIPEPVQRRIVYWSFPRSEREICMYSSFDTGAEGFTAPGSAAGNTASGGAVDAVADENRLPFRRGMALLDGGCVDNVLQVGFHLSGTVTEPAMQSEPETVFNVAISFDRCKITSVTCSCGNKDIFYCAHVVALSLYRIRKPDQVKLHLPISETLFQMNRDQLQKFVQYLITVHHTEVLPTAQKLADEILSQNSEISQVHGAPDPTAGASIDDENCWHLDEEQVQEQVKLFLSQGGYHGSGKQLNLLFAKVREMLKMRDSNGARMLTLITDQFMADPRLLLWRQQGTAMTDKYRQLWDELGALWMCIVLNPHCKLEQKTSWLKQLKKWNCVDVCPWEDGNHGNELPNLTNALPQGANANQDSSNRPHRTVFTRAIEACDLHWQDSHLLHIISSDLYTNYCYHDDTESSLFDSHGWPLWHEHVPTACARVDALRSHGYSREALRLAIAIVNTLRRQQQKQLEMFQARKKELLYRGITSITNLEGWVGHPLDPIGTLFSSLMEACRVDDDNFHGFSDFMENTSQHKSLEYQHLPAHKFLEEGESYLMLAVEVALIGLGQQRIMPDGLYAQEKVCRNEEQLISKLQEIELDDTLVKIFRKQAVFLLEAGPYSGLGEVIHRESVPMHTFAKYLFTSLLPHDAELAYKITLRAMRLLVLESTAPSGDMSHPHHIASIVPNRYPRWFNLSHIESQQCELASTMLSAAKGDVQRLETVLQSIQKNIHSSSHIFKLAQDAFKIATLTDSLPDITLLKVSLELGLQVMRMTLSTLNWRRREMVRWLVTCATELGVHALDSIMQNWFTLFTPTEATSIVATTVMSNSTIVRLHLDCLQQEKLAGSARTLALQCAMKDPQNCALSALTLCEKDHIAFETAYQIVLDAATTGMSYSQLFTIARYMEHRGYPMRAYKLATLAMTHLNLSYNQDTHPAINDVLWACALSHSLGKNELAAIIPLVVKSVKCATVLSDILRRCTLTTPGMVGLQGRRNSVKLMSLDKAPLRQLLDATIGAYINTTHSRLTHISPRHYGEFIEFLSKARETFLMSHDGQIQFTQFINNLKQIYKGKKKLMMLVRERFG", "length": 1168 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0YDY5-1", "protein_name": "SKA complex subunit 1", "gene_name": "SKA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAEGLEALSRHLAAKIGLIKRLLQLRGLGRREMLAEVGMEVAVLHGLLGRMEEEVNQRRQLAAALQEMRKRAEKEKWEAERLQLVKKAAKEAPLVNDAPLISDEEFESVPGYMRGRLTLAQTNAALRALHAAAASKYRLLRHPPKSLPSSSRALCHRFREEETKETQGLTFVVEADLKEFTQLKVDRTFHRIVGVLRHCRRLREVRGARLVRYVLP", "length": 217 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0Z0M2-1", "protein_name": "Tumor necrosis factor ligand superfamily member 10", "gene_name": "TNFSF10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPAGGPSPAHTCGAVLVAAVLLQSVCVAVTYIYFTNELKQFANADLVHSCERGHPLSPPPPPDVPQTAVTRPTKAEGGAAPVGASCSIGQSRRAQSDLRQRAANAASPQHGPPCAARSRARCSCPRCTAGPRVCRRTQQKLWDTYSRSGTACLTGEELGDLIQNLDVVESKDRVADPCWQVKWHLGKLIKKMMSRILQENMSAINGDRTQALPRRDEPPQGPTLRIAAHLTGSSKRSSASPHIDYLSYRGIGHKIHSWESSRRGHSFLYNVELWNGELVVPQTGFYYIYSQTYFRFRENEDEDSGLLERIKNPKQLVQYIYKLTNYPDPILLMKSARTSCWSKKAEYGLYSIYQGGVFQLKREDRIFVSVSNSDIVDMDKEASFFGAFMIS", "length": 392 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZCD9-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418390", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMSALLFTLLHYWKIWFCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEREEQQEQVEEEEQLERVEELEQEDQVEHVEQEEQEEREDQGEQVQQEEQVEEVEQEDEEEEYFHHSALTRYIARRAWEKMQGKATKCVLVEELMSDLLQTYTFVCSNSFYPVLQPAIGVGSAFEGWSPCEEDIVYRLLVPIKAPHGHVFHPELGEEGEVLARNSRIRVELVCMCTREQQLGDVLCFLHHSEEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRTWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAVFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSTYAIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKVLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRVLRDFKELKDRLFRLLLFGR", "length": 542 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZD85-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418382", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMPALLFTLLHYWKIWLCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEPEEQQEQVEQEEQLERVEELERVDQVEHVEQEEREDQGEQVQQEEQVEEVEREDEEDEYFYHSALTRYIARRAWEKMQGRATKCVLVEELMRDLLQTFTFVCPNSFYPVLQPAIGVGSAFEGWSPCEEDIVYHLLVPIKAPHGHVFHPELGEEGDMLARNSRIRVELVCMCTREQQLGDVLCFLHHSQEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRIWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAIFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSTYAIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKLLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRALRDFKELKDRLFRLLLFGR", "length": 539 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZE07-1", "protein_name": "LIM domain only 1", "gene_name": "LIMO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRDSNPMGWYGSHPVTAAWEAEARTTSLGQPGVRAAELP", "length": 158 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZGC1-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "LOC124416945", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVAGSPALLLLLSLGLCFTGAQGQGNTMAVSFLNRSMKHPKEGQRLGLECHTYKTSWGVSWIRLDKDGNLHFIVYISKFSSTTFPGNKGASSQFEVSKQGSSYRLTVKNFRAQDQGIYFCIANINQVLHFSSGQRAFFPVTTTTAAPTTLRAVTLTATTQSSQVTMKDISQHSPDPGRSKENMPNFCCKLVMWVNLACACLLLLTAITITTTHCQRPSSP", "length": 220 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZPB4-1", "protein_name": "trypsin", "gene_name": "LOC107049069", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKFLVLVAFVGVAVAFPIRDEDDDKIVGGYSCARSAAPYQVSLNSGCHFCGGSLISSQWVLSAAHCYKSSIQVKLGEYNLAAQDGSEQTISSSKVIRHSGYNANTLNNDTMLIKLSKAATLNSYVNTVPLPTSCVTAGTTCLISGWGNTLSSGSLYPDVLQCLNAPVLSSSQCSSAYPGRITSNMICIGYLNGGKDSCQGDSGGPVVCNGQLQGIVSWGFGCAQKGYPGVYTKVCNYVSWIKTTMSSN", "length": 248 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1A1Z3-1", "protein_name": "Bridging integrator 2", "gene_name": "BIN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSLYHPNAIPVPFPSHPCTTLMSSLTHHIIPVPSSCLPNVIPIPYHPHVISTLSLLHPHFIPMAFLNLPHAIPVPPLIHSCAVPMSYHPFPISFSFPSPSHPSIAPMQSPSYPYPTPVPPPFHLLPIPIPTPVPPPCHSCSIPIQPRCRLHAILVPFPPHCHPHPVPAPSPPHPSAIPMPSHFHPHPIPVPPHTISIPSPPQCHLHAIPVPSPTHPHPIPSHPRFPHPLWAQGHPHPRGSNLSPPIPPPPPNTFALQNEGNKLYKDLKAFVGAVKVMHESSRKVAETLQEIYSTEWDGHVELKAIADSNDLLWDDYEAKLGDQALRLMENYLAQFGDIKERIAKRGRKLVDYDSARHHLEALQNAKKKDEAKIAKAEEEFNRAQAVFEELNRELREELPVLYGSRIACYVTIFQNISNLRDIFYKEMSKLNRDLYEVMGKLDKQHSSKVFIIKGVPSKRRSLLISAPVSPPAAYPCPGKAPNWDPSSGAEQTPTSPRVGSDATEDVPNGLAAPGPAEPGAPMPGPPPASPTSVRSASESESECSEESREIDLSPKEMEVSVGSGCPEYPKTEGAAKGEVEGIAASMASMIVSEAIAAATGAAPGDSDGVGGGDSTDSEISPAEGAWGGPSPGGSEERVEGTDVSPEVGSDAGPCEHGTPEPPQQDVSCDPPQDPSESLTPL", "length": 682 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1A7J1-1", "protein_name": "Mitochondrial transcription termination factor 4", "gene_name": "MTERF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGRLLGLLRARAPRAVLPAPGPASRHRCGTAGPEEGEAAELLAMGFSQAQARRLRLLRPGLEPQRRAEAAAQLLLLGLSAEAALGLLERSPGLLRMETARLKERAEYLRRLGLEGERGGPLPRGVHAAPAEDGGGGAAAAGAVSVHGRAADRAAAELPRGAAGGAGPRAAPLPGAGRRAGRSGGVAGAARPALSSARLHAQYAYFRMGVRQKEMVKARLFRTPFAELRNRHVFLERRGLYRTPHKGQSQSGNPALRDVLRPTEGDFVAGVARASPDEYEVFKRLLAREEEEMEEEEEEDEEEEEEEEGSAALHAEGGDRDWHSSEPSPIAPCPPAPQ", "length": 338 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1AKD9-1", "protein_name": "Borealin", "gene_name": "LOC121107214", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPARRKAAAGARGRKLSAFLKDFDREVRSRVEQLRTNGERLVKEMENLYDVELLRLPAALREMNWLEFFAKGGSQKVVEEAVTADLGITEINKLTAELIQTPLKIVTKEKSKQGIEATEEAAEVPLLPPAKKAKHDSQLLLEQAAASTNPRNGKVRTSTKKAPVSRSRRAPSARVKRVSKRSSKSSFITPATGRNLDLCARGGASIVTPRFDSRVFKTPGLRTPAVNERVYTISANGSPLADGNDVFITVPVGGGESIRLTASDLTKKNLLHLNPEARGIMKKLSVRLAQACSSAKTHR", "length": 300 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1AMC7-1", "protein_name": "ODF3A protein", "gene_name": "LOC121107218", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPASMDGAWVGTWRPHRPRGLISAQFPSPGPQYSIPGTTGYVGHSPTKARAPAYTFRGTKPPAAGSCGPGPCYFVEPAITRNGKYVAPGAQLRGRPVTKTTVTPGPSDYRTEAANRHVFKCPPVQSMAFRREPLRTDHPPGPGTYTLPRLMGPNTVYTSASPCYSVRGRSQRGRFDEDLAKTPGPAALPKVPVDAYKTRAPAYTMAARPKAGEGKAAKPGPADYSVGRVTLIKPQAPASTFGIRHSLYTTPLIVE", "length": 255 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4F7J1-1", "protein_name": "40S ribosomal protein S26", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQPIHCTNCARCMPKDKAIEKFIIRNIVEAAAVGVISEVSVFAAYVLPKLYAKRHYCESCAIHSKVIRNRSREAQKVRTPPPRFRPTGAALRPPPKCM", "length": 98 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4F8K9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258234", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNHTVTTFILLGLTDEPQLKTLVFIFLFLTYMLSVTGNIISLTSTDSHLKTAMYFFLQNFSFLEIAFTSACIPKYLYNIATGDKTITYNSCATQLFFTDLFAVTEFFLLATMSYDRYVAICKPLHYVTIVNHTVCRRLIFGSWLAGLLIIIPPLSLGLKLEFCDSNVIDHFVCDAAPLLKISCSETWLIEQMVIVCAVLTFIMTLMCVVLSYVHILKTILQFPSAQQRKKAFSTCSSHMIMVSISYGSCIFIYVKPSPKDSLAVNKGVTILTTSIAPMLNPFIYTLRNKQVKQAFNDAIKRIALFSKN", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4F9E2-1", "protein_name": "UPAR/Ly6 domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "RLEFSSLSPAEVPLVAAAGGRGAFDMRCHECDTKNTFACDHIVTCPRGIRRCLTLSIRLSSREIYVYKGCTRNCTFIYADEQPPPGERKPPRSNSLYFVQCCNAITCNRGGPINLEKDITPPLILEEELGGTVRLGEATLFLSVASVLVSHALT", "length": 154 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FBC5-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTHSFSFFSSSSSSSTYSSSYPLLPLLLQPQNQFRIWALKDYGQRNSTSLHDFILLGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFLDLCFTTSIVPQMLLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKIACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSTAGQRKAINTCGSHLTVVSIFYGAIIYLYLQPGNSASKDQGKFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 331 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FBS2-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258626", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNHTAITTFILLGLTEDPQLQLLLFLFLFLTYILSVAGNLTIITLTLLDPHLKTPMYFFLQNFSLLEISFTTACIPRFLYSISTGDRTITYNTCFTQLFLTDLFVITEFFLLATMAYDRYVAICKPLHYMTIMSNKLCKTMVVCCWLAALLIILPPFSLCFHLEFCDSNLIDHFACDASPLLKISCSDTWLIEQMVIACAVLTFIITLVGVVLSYIYIIRTILKFPSAQQRKKAFSTCSSHMIVVSITYGSCIFIYINPSAKEEVNLNKSVSLLISPISPVLNPFIYTLRNKQVKQALHDSLKKTAFLLRK", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FCJ2-1", "protein_name": "Histone H2A", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRKRNLPQCNPPKKQALSRSSRAELQFPVSRVDRYLREGRYAQRLSSHTPVFLAGVLEYLTANILELAAGEAHSSRKMRIAPEHVQRARSHNETLSSLFQASSVSRGAEEEAEEPLPEAGR", "length": 122 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FD42-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTALNHTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFIILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLNCCITQLFFIHSIFVFESGLLLVMAFDRYVAICYPLRYTTILTHPLIGKIGVTIVLRSYCAIFPIIFLLKRLTFCRSNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLLLDILLIFVSYMLILHAVFHMPSQDARHKALNTCGSHVCIIILFYGPGIFTALTQRFGRHIPAHIHILLANVCILVPPMLNPIIYGIKTKAIQEQVALILFPKYR", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FH98-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "VCHYGNYYSGLSCSCGYGCGYSRCGCNCDYDKCGYRCGYGGYVYGCCHLSCCGRYRPYGFY", "length": 61 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FHY5-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "DTGSCGAIVLTQTPLSLSVSPGEPASISCRSSQSLEEYGKNWLSWYQQKPGQSPRLLIYQATNRASWVPERFSGSGSGTDFTLKISRVEAEDAGVYYCQQYKEFPPTVIQPLTQTPLLGAQLHTWLCVVWGAEGQKL", "length": 137 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FIZ4-1", "protein_name": "Envelope glycoprotein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPTLSRRHLPTRGGEPKRLRIPLSFASITWFLTLTITPQASSKRLVDSLTSPKPLSLTWLLTDSSTGITINSTQREAPLGTWWPELHVCLRLVIPGLNTMSTPPDILRAYGFYVCPGPPNNEEYCGNPRDFFCKKWSCVTSNDGYWKWPTSRQDRVTFSFVNSYTSYNQFNYGHGRWKDWQRQTQNRQISCSPSDLDYLKISFTEKGKRENIQKWINGMSWGVVYYRGSWGGEGSILTIRLRIETQMEPPVAVGPNKVLTEQGPPIQGQRPSPNPSDFNTTSG", "length": 284 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FJ61-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSTKNKHLMKGSKKGPKKKVADPFSKKDWYDGKAPAMLTKKRNIRKTLVTGTQRTKITSDGLKGHVFSSEPCQSAE", "length": 77 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FJT7-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKNPEVRKIHSAVFLITYLSTILGNLLIVVTMVTSQSLRSPMYFFLTSLSLMYVTYSSVIAPKMIVDSFSETTAISLEGCMAQLFAEHFFGGVGIILIIVMAYDHYVVCCLLLGGAWVGGSIHATIQLLFICQTPFCGPNVIDCFMCDLFTLLKLACMDTHLLGILVILNSGVMCMAIILILITSYVVILCSLKSYSFEGQHKALSTCGSHLIVVVLFFVPCIFLYVMPVATYPIDKAMAVSFTIVAPMLNPLTCTLRNAEVNNAMRKLWMKQNTLCYH", "length": 279 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FKQ6-1", "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVQDQDEKKNPMWELGIHKLCLNICEGESGNRLTRAAEVLKQLTGQSPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEIFERHLRVREYKVQEHISLGTKYDPSIGIYSLDFYVVLGRPGFSFADKKHRTGCIGAKHGISKEDAMSWFQQKYDEIILPGK", "length": 163 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FKY3-1", "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKFVKPGKVVLVLAGRYSGRKAVIVKNTDDGTSDQPYSHALVAGIDRYPRKVTAAMGKKKIAKSSKIQSFVKYSVDIPLHKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKCFFQKLRF", "length": 125 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FLM5-1", "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGHQQLYWSHLRKFGQGSRSCCVCSNWHGLIRKYSLDMCHQRFCQHMKDPGFIRLD", "length": 56 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FNC8-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLIAVSGNTLTILLICADPRLHTPMYVLLTNYLSGTKSISFVGCATQYFLFLSLGCAECILLTFMSYDRYVAICHPLRYAVLMNRKVGQMMAVMSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYEIAVYIGDIVLLLLPIALISASYVFILHSVIRMHSAGGKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALKRVLGREMITQNPKVRLP", "length": 301 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FP10-1", "protein_name": "Ribosomal protein L19", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVLRLQKRLASSVLRCGKKKVWLDPDETREIANAKSRQQIWKLIKDGLSIQKPGTVHSRARCQKNTLRKGTASAGMPKKSVPERDGNVFKNKRILMEHTHQLKADKARKKLLADQPEARRSKTKEARKRRQERLQAKKEERNRTEVETKFCRLI", "length": 155 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FP36-1", "protein_name": "Small ribosomal subunit protein eS24", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQDTASIRTRKFRTNQLLPGKQRVIRVLHPGKATVPKTEIWGKLAKMNKRTPDVIFVFGFRTHFGGGKTTGFGMSHDSLDDYTKTNEPKHKRARHGLYEKSKTSRKQRKERKNRMKKVGGTAKANAGAGQKGGV", "length": 134 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FQE1-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTALNHTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFLILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLDRCITQLFFIHSIFIFESGLLLVMAFDRYVAICYPLRYTTILTHTLIGKIGVTIVLRSYCAIFPIIFLLKRLTFCRSNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLFLDVLLIFVSYMLILHAVFHMPSQDARHKALNTCGSHVSVIILFYGPGFFTTLTQRFGRHIPAHIHILLANVCVLVPPMLNPIIYGIKTKAIREQVAHLLFPKQK", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F7T0-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "LOC100757015", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDYVMQFVEPSGQFVKDSIWLVKRCTKLDRKEFQKVAMSTAMVFAIMGFTGFVKLIHIPVNNIIVGG", "length": 67 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7GY23-1", "protein_name": "Tetratricopeptide repeat protein 16 isoform X2", "gene_name": "Ttc16", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDSSTEESVNVQTQKIPKLQVPETRETTLQRIFGTSQVFYSVSGVVKPRLTESTVPFRVREYYHQGHHCLEQEDWEMAVLYFSRALHLNPDQVEFYIFRAEAFIQLCDFSSALQNLRRAYSYEPENSKYLERLAFVLYLQGQCLYELCDFQEALYVFLQASDLQPQNPSFSYRCMACLLALNRHQDCLSLVTREVKQGRATADVYILRARIYNFFQKPKLCYQDLRSALLFNPKHPQAKGLLQVMVDQAKKSLQDASILAVQGKLHRALKRISCAIENNPLDPNLFLFRGTLHRRLQQFDPAVEDFLKAMDMVTDSQDNLVQKTQRQLLLTYNDFAVHCYTQGAYQEGVLLLNKAIRDEQNEKGLYINRGDCFFQLGNLAFAEADYKQALELCPKDEGANLRMGVLQEKMGLCEQTRRQFQKAEDHFSAAIKYNPVNAQYYLHRAKNRQLLQNIVGACQDIATVLLLNPKYPKMAPLMAKLFPGMSVEEVLNSHVAQLAKLQLRRMIESGPKASHPQSIVAKRLIERQKAQALMESWNWEQLFTRNPEEEVAPSESLQGKTLREKIEFKREVVEEKKVKILRKVTSLSDSYVDQTSSGSEFSILSPSTLETEVSTMEYKSTSNTAASSAERLLPQYLVTTKYKESLGLSMAPNVTQVSEDLHKSLTENIPDDGPRHHSSKAEATQRPKPRKTEPSQSLGKQRPSQRPSITEATKGPKPRKNRPALSPRQRLRRAKAVQAQNWKPRTNSNSQKTSSLLSNIAVIISSSNEAQDQSPVPSKADDISSYNDSTATSSTNTDSLRLSIHLSKPKYSKDQSPSHNKEEVSPTSNNYAAP", "length": 835 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7GZF8-1", "protein_name": "Protein EURL homolog isoform X2", "gene_name": "C4H21orf91", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIIKRKATVIHHKGTMNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNLEGVPKSNLLHTRSLRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTLLTKKINWIVQYAQNKDMDLDSECSKNTRHHLFNFRHKPDKKLLPQFDSQVPKYSVKGIAGSTGGLSSYTQRILEQRENTDFGLAILQDSDALWPHKHNQAQKKEETSSGPENVQTQNPRYSREELNSMTLDEVEQLNTKLQQQIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNYSKLPCLQVGRAGPRSHLPINN", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7JMJ4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100771730", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDFVNISLVTEFFLVGLTDQPELQMPLFFLFLAVYLITALGNLCLIILTVLNSNLHTPMYFFLFNLSFIDICYCSVFTPQMLMNFILRENIISYMECMAQVFFFCFFVVSECYVLTSMAYDRYMAIYNPLLYNVVMSPNLCLNLMFGSYFIGFSNAVAHTVCMLRLTFCDTNIINHYFCDIPPLLQLSCTSTYVNKLVIFVFASINIIVPTSTILVSYGFILSSIFHISSSEGRSKAFSTCSSHIIAVSLFFGSGALVYFKPSSAVYMNEGKISSVFYTNVVPMLNPLIYSLRNKDIKVALMKSLNSRNL", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AA74KSW7-1", "protein_name": "Predicted gene 3002", "gene_name": "Gm3002", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLNSSKLGVWAAGVPPSSPTLLFRRWVMKVESLISQPMTSGKNELQDHLIFISEKALHKRLFQKENGDEGVTRPTEKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNTSPAESRTWHRPGHDLPQREVLEEEH", "length": 280 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0AAA9RU54-1", "protein_name": "Small integral membrane protein 17", "gene_name": "SMIM17", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MQSLRPEQVRGLLEPERAKTLLPRENKAWEKRAAFAKDWVAVEVGASGCGSDEKDLPSPKTLVPQEWSSVEEDDESEDSQPHWAAALPTSPSCPSQDTGTGSGADLCLQCSSPRTPPWLPWAFSHTIESALPTPPRAWLWSLL", "length": 143 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0AAA9RY85-1", "protein_name": "Core Histone H2A/H2B/H3 domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNMPEPAKSAPAPKKGSKKAVTKAQKKDSKKRKRSRKESYSVYVYKVLKQVHPDTGISSKALGIMNSFLNDIFERITGKTSRLVHYNKRSTITSREIQTTVRLLLPGELAKHAESEGTKAVTSIPALSKYNMPSRC", "length": 136 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0ABK0KVZ2-1", "protein_name": "Eukaryotic translation initiation factor 1", "gene_name": "Eif1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "EFGFRSVASAGWGAACPLGLRHVISCGGRAGLEQKARALSSSSTGLFPEGQQRAPPDFSDDICTDKKKNQERGINKWPTTTRNKNYFFVDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLIEIGLAKDDQLKVHGF", "length": 192 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0L002-1", "protein_name": "Oocyte specific homeobox 2 like 1", "gene_name": "Obox2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "ILQSVQNTDMIEGPSFLPKFQMSSYTPMDTSSQLPQEPSWNLAFQMGQSPLVTSRTPMQSSPSVPEQNLNWQESQGSSRESSIQMQPGPVMDPGFPTLRSPSGHPSHQRPSRPSSRSGFHVPIEPMALSDKHGGKQTGPVAPRKCRKERTQYSAKQKSVLQEHFAECQYPDKKLCLELATLFGVTENEIKVWFKNNRAKCKQKNVPEALPETNGGPEAVSWSTDFPGSIAVVGCDQGEPMATAILDVDSTPKLNCSQESSLDGNWTYDGAMCCLPEDVLDGNDPVTAGDSGESAPVEAQSDLAAAGAPVAMAVDTQNPEECEDLPLLDEGVWQWMLEDFHQLEDWFTKNYIESPSSASHPLD", "length": 362 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0LHI6-1", "protein_name": "CD27 antigen", "gene_name": "Cd27", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWPPLYWLCMLGTLVGLLATPAPNNCPDRHYWIGAGLCCQMCGPGTFLVKHCDQDRAAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECTCSKGWQCRDQECTECDPPLNPALTSQPSEAPSPQLPPPTHLPYATEKPSWPPQRQLPDSTVYSRLPSQRPLCSSDCIRIFVTFSSMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQEDYRKPEPASYP", "length": 251 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0LYA6-1", "protein_name": "Prostate and testis expressed 2", "gene_name": "Pate2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSCLTSELQGSACLCLPSTGSYKHILQHLDLGTMCYKCKKYHLGLCYGLMRSCTLKHRQSCAAENFYILTNRGQSMYHYSRLSCMTNCEDINFLSFERRTELICCKHSSYCNLPMGL", "length": 118 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0M6C3-1", "protein_name": "Prohibitin", "gene_name": "AABR07037878.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNKNIKNSISISVCVGGVGGVRARAHAHAHTSPHACTRVIHAFVMLEVGPRDFVHIKKAFRGIDVKKPVIFDCRSQPRNVPVVTGSKDLQNVNITLRILFRPVTSQLPRIYTSIGLDYAERVLPSITSEILKSVVARFNAEELITQRELVSKQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAETARFVVEKAEHQKAAAIISAEGDAKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSSSQNITYLPVGPSSVGPSVRQSMFLRLPQ", "length": 286 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AC58FXL6-1", "protein_name": "Cytochrome P450 2X10.2 isoform X2", "gene_name": "cyp2x10.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDLRGIYSYMLSTVNSLVRDSSLTNFKKEFCVHAYLLSVCIQYQSSVWSSSRSVTMLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKDFDKFAQHYGSIYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAMLYEIAPVLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEMENKSDHRTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVLRRFRLVWPKDAGEPDFTYIYGGTQSVKPYRVIVEPRMHGEACKFVD", "length": 552 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58J797-1", "protein_name": "Uncharacterized protein isoform X1", "gene_name": "si:dkey-233e3.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANAKQLLKNSLDELVEAELKEFQWYLINDHRDISKAEMEKADRLKTVDKMVSCFGPKGAVKTTVDILRKINQNELAEELENKHKQGNCMSARAEGAVLETCKSPPFDYTNTSRELKKKLKEDYEKILVGNSQTGHKKYLEDIYTDLYVVENETGGRERQHEVIQMESKHNQQDRPLKCNDMFKVQPDTGRKHRRILTLGIAGVGKTVSVNKFILDWAEGKDNQEIVFIFPLPFRRLNLIKEEKYSLIGLLNKYFFSISGGLSSLPEKQGKVMFIFDGLDEYRFKLNFKKDDGFTDVNKEMTVSEIITNLLKRHLVPSSLMWITSRPAASSLIPRDLIDQVTEVRGFIDEQKEHYFIKNSSPEVARNIIGHIKKSRSLYIMCHIPVFCLISLTVLQPLLGQESNEKTPTTLTGMYINFLLSQKQQMKEKYRNDTESEANACSFDEIVLKLGKLAFKQLQKGQLIFYKTDLEKCGLDVRQGSVFSGLCTRMFQEENHYSGEQVYSFVHLSVQEFIAALYVFFTYKNKKANLFLDSWKKELKWKLSEKPLFKLHTAAVKKTLQSKNGHLDLFLRFLMGLSLESNQSDMKELLPWLKLKTGMIKDTTDYIKKKIEEENSAERTINLFHCLNELNDDFVEELQKSLCSGNLTAQDLSSAQWSGLVFVLLMSEETQEKFELQKYRRSDEALMRLIPVVKNTTRALLQCCNLTAQSCESLSSALQSSNCVLRELDLSNNDLQDSGVNLLSNGLKSPKCKLEILRLSGCMVTEEGCGFLSSALTSNPSHLRELDLSYNHPGDSGLKLLSQKLEDPNYTLNKLNLDHGGEKWFTAGLHKYACFLTLAPNTAHIELRLSEENRRVTRVGERQQYPDHPDRFDHHAHVLCRESVCGRCYWEIEMNAGDRVDIAVSYKSIKRKGRGYECVLGQNAQSWALICYVNRVAFRHNMIETRLPVKLMSRRIGVFVDHSAGTLIFHNIYRDSMSLIHSVQTTFTEPLYPGFWVEYGSSVKLC", "length": 1006 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58JHM1-1", "protein_name": "Phoenix isoform X1", "gene_name": "pho", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDLRSKGDTSVGEVMEADPRAELIFETPPPDVVSSINACFEEIDSALKIRRDPSVHSPPSDSDSESLFITQSVTKVVHTKRRLRSSKKPDSISDDSGYVRERRLSENQQTECEEESRSLRSSRRKRSKWEMYASARKATFPFLMKSLKTQHLPIRKHQILENSEVGGFFKCIKKIKTGSVKMGKVISSHLFQSPISDSSEEEDQNSEHDVISVDKALFVPGYKRGINFKWLPDFIRERRTLENYLSNGVDKEKKTEQIIEYRQRNQHPQRTSAKALSKSSQVSKKPKKQDTHEVLASCSDHEDLEIAECAENSHEGHKVVIEETQRQTVEEASAHLEHEDDLNCKVVEYRKRKRHPKRTSAKALSKSSQVSKKPKKQDTHEVLASCSDHEDIESVECAENSHEDHNVVIEETQRQTVEEASAHLEHEDDLNCKNQPDVDQPNESNFIGPPQEGDISTQSDTQQTDSDIGSVDLFSPLNSPKRDDQIPNTTSITANVEENDQDSDVTQIESEGQHVSTFTQETQKCFANEEYDSDETHIDTESLSRFKPRTPNKQFTSTKHPEIPQFRVQSPKPPSRQAETVNVQLSPKHLPLSNVPLSEVPISPCESAIVGRQKTMVETETDSPMFKITGPSFLKRKRKRTKDKNAAADFKQHDTNGDVGQMVSCPGDDITGLKAVPIENIEACGVEHEMAIGEQTEELGLKSKELLEESVLSTVNSVSTKSKREKMKKYKVKECEAVENQLVETSKKAKKKKKDKERIATSYPEENNLTNIQSNEGFDSAELRVKEVNQSSQSLNTDQPTCVQTSEEITGETELKKKTTRHETDDPLYESVGLDVTLASQFDVGLRIDEQQEGLVTEEAERDERLQGKAMKVAKGKKKIQDTSFQVDHDIGLDKQRSDSGAKPANLDLDGLESLTIKKKKKKKKKHKLKEKTDPKLDFDFDHNVQFFQTDRLQTTDSVLLDSTHTNKQKKKKLKCQNDTDQSSDLKQLHVVGSKLQTIDLPKTDKHMERTGVSSSDALLEHMDDRTLGMRENNTIQTDQIEHLQTSEEVTRCSSPRLSSDKKREKTSVHPNLDASSVFQFDGFKANEDQAITQNTTKEKQISSEQLENNLVGPPSQVENIANVNSSVLLDHTHMNTLREGQLKEQTYKELALAFGLKQLCIVVNKLKTTDLPKTNKNMEGTGVGSSDELLKHTDDRTLETRENNTIQTNQIEHLQTSEKVERHSSPRVTRLSFAKKWMKTSVDSNLDASSGSQFDGLNSMAKEDWTFSQNMDLPLKRTKNKQKDKERTGVSSDALLKRMDDRPPEMRKKNTIQTNQIEYLQTSEKVTRRSSPRLTRLSLAKKMEKTSVDPNLDASSGSQFDGLKEASKEDRTAPRNSIEEKQSDAISSEGLENNPAHLVSTNKSDNTSPSSQVDNIVGLQSDANSVLLDHTHTDKQKKKKIKHKLIEQTEKELTSEVEDNVQPFQFIELRAMDLPSKRITNKKLKDRKRTGVSSSDAVLKHIDDGPSDMRENNSIQTDKIEHLQTSEEMTRCPSPRLSSDKKRKKKYVDTNLDASSGFQFNWSNGMAKEYSKNSTNISSLDNMHTSKQKKKKKQKLKEQKNVESVGDNVYSLEPDQFSGLQITEIKTKKKDKKRTKQANVEENDLKGILSNKAFKASQTYQLEHIQTSEEIKGRSPNAASKSAKKKKKKKNETKNPQYESVNLDLSLAKEDRTTTQNHTEETQGDGNAVEHLEMNPAGLIKVSKKKKKRENAGIVQLDNIIGLQSGSSTDVKSSVLSDSTDTNKHKKKKRKTLKEQENVEAEGDDVQSVEPDPFSGLQITEMTTKKKRKHKRCEEQRCLRGVSSHEAFKAPPTNLLQHIQTSEEISQCQSPNVAALENGGSPYQLENITEMQPGNSIDINSSEILYSTCTHKQKWKKLKQQENVEADANDVHSAELNLFSELKISEPTTKKKKHKKCVEKCALKDISSNEGIKAPQTSQLEHVQTSKEITQCQSPNAATLKSEKKKKQKRDETEVPQYLDASSVSQFDDVTRLKKQAKVDRTTTQNSSEETQNDDISSKQLEMNPAHLIKVSKRKKKREKAGSPYKVDKIVGLQSGNFTDVNFSQLSDSKRTDKQKKKKKIKLKEQENAEADVDDVHSVELDQFSGLQITKPTTKKKRKHKRCVEESGLRDISSNEAYKAPQTNQLEHIQTSEEITPFQAPNVAALKSAKKKKKKRDKTVEPQCLDASSVSQFDDVKTRAKEDQTLTPNSSKETQGDDSAVECLETNPAGLMKVSKKKKKRENAASPYKVDNIVGLESGNSADVSSSVPSDSTDTNKHKKKKRKKLKKQEIVEADLQTSEEIIQCQSPNVATLKSVKKKKDETKEHQRLDVSSVSQFDDVSRLKKRAKEDRTTIQNSSEETQSADISSEQLEINPAHLIKVSKRKKKRENGRSPSQVGNIVGLQSGNFTDISSSVLSDSTRTDKQKSKQKKKLKEQENVEADANDFHSAEPDQFSGLQITEMTTKKKKKHKRCVEESGLRDISSNYAFKAPQTNQLEHVQTSEEITQCQSPNVAALKSEKKKKNKRDKTDKPQYLDESSVSQFDDVKKRAKADRTTTHNSSEETQKDNISSECLELNPAHLMKISKRKRENKSLGLLSENTADLNSSSLLDGTDTDKHKKKKRKKLEGQENVEADVDDVHSAEPDQFSELQIPEMTTKKKKKHKRCVEESGLKDISSNEALKALQTNQLEHIETSEEMTIKTVKKEKKKRDATEEPHYKSVDLDVSPTESTTEAKLNPTKHKKKRKQSFSGSHDAHEAPERKRKKDRN", "length": 2809 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0MGZ5-1", "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1-B", "gene_name": "hs6st1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNDTERNMVERTSKFLLIVVGSVFFMLILYQYVAPGVINFGSPHGYLLGEEDMTIFPTPDPHYVKKYYFPIKDLERKIDFEIKGEDVIVFLHIQKTGGTTFGRHLVQNVRLELPCDCRPGQKKCTCYRPNRKETWLFSRFSTGWSCGLHADWTELTNCVPGVLNKRESKSKKMRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQQFMDCPYNLANNRQVRMLADLSLVGCYNLSTVPEKRRSQLLLESAKKNLRDMAFYGLTEFQRKTQYLFERTFHLKFIRPFMQYNSTRAAGVDLDNDTIQRIEELNDLDMKLYDYAKDLFQQRYQYKHMLDRREQRLLRGHASFHSPFREDGAGGEGTARLPTEDYMNHIINGW", "length": 407 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A1EC97-1", "protein_name": "Dual specificity phosphatase 14", "gene_name": "Dusp14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRASVASNRHLLQARGITCVVNATIEIPNFNWPQFEYVKVPLADIPHAPIRLYFDTVADKIHSVSKKHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLIDYESQLFGKSSVKMVQTPYGIIPDVYEKESRHLMPYWGI", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A1XQX2-1", "protein_name": "Neurexin-1b", "gene_name": "nrxn1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMILHLGAHLLFIGLIVCKANAGSSLRFTGSDEQWVAFPMWNACCESEMSFSVKTTHLNGLLVYFDDEGFCDFLELHVHVGKLRLCFSIFCAESTCVLSDVAINDNRWHSVSIMRNFRNTTLIVDDEVKWEEVKSKRRDMTVFSHLFLGGIPSELRSVSLQLTSKTVKDHTSFTGWIMDVKVNDSEPAIISSAGVHEDLCGSENTCLNGGVCSVVEDKPTCDCSQTGYQGKDCSEGLAHLMMLDRGMEEYVATFRGSEYFCYDLSLNPIQSSSDEITLSFRTLQRNGLMLHTGKIADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNEWHDVKVLRNLRQHSGVGYAMVTISVDGILTTTGYTQEEYTMLGSDDFLYVGGSPSTADLPGSPVSNNFMGCLREVVYKNNDAELELSRLAYQGDPKLQIHGVVAFKCESVATLDAITFETPESFLTLPKWNAKKSGSISFDFRTTEPNGLLLFSCGRAKQHNKEAKSPVTLKVDFFAIEMLDGLLYLLLDMGSGTTKTLALNKKVNDGEWYHVDFQRDGKSGTISINSVRTPYLCPGDSELLDLDDPLYLGGVPESSSGTVFPTGAWSALLNYGYVGCVRDLFIDGRSVDVRRAAELQRAAGVKPSCGKEPSGKCVSEPCLNRGVCREGWSRYICDCTGTGFLGHSCERDATILSFDGSKFLKVQFSAAMHTEAEDVSLRFRSLRAYGVLMASTSTHTTDTLRLELEAGRVRLTVNLDCNRINCTTSKGPESLFAGQNLNDDEWHTVRVIRRGKSLKLSVDDLPTVDGEIPGDHTQLEFHNIETGIITGKRQLPTMPSNFIGHLQSLMFNGKPYIDLCKNGDIDYCQTNAPIGFKSIIADPVTFKSCSSYVTLPSLQAYYYMYLFFQFKTTSADGLILYNSGDGNDFIAVELVKGYLHYISDLGNGAHLIKGNSIKPLNDNHWHNVMISRDPNNLHTVRIDTKTTSQTTLGAKNLDLKGDLFVGGVPEQMYKDLPKLVHAKEGFQGCLASVDLNGRLPDLMTEALVCIGQIERGCEGPSSSCEEDSCANQGVCLQQWENFTCDCSMTTYAGPLCADPGSTYVFGRQGGVITYSWPPHDRPSTRVDRLALGFITLMEDATLVRVDSSAGLGDYLKLHIVKGNVVAVFNVGTYDINIEENGKLVNDGNYHIVRLTRSGGNATLQVDDLPVIERFPPGHIDSHRLGTGRLPYRRLVEESLPKNGRQLTIFNSQMTIRIGGWQKQQVSGFQGQMSGFYYNGLKVFSMAADGDPNVRMEGSVRLVGELQSSSTPHGGATVYQSSVTEISSTTSNTITITYSTPADEQQTTDELLVASAECPSDDEDIDPCEPSSGTLCCFVPPAGPTGPAISSFPGPAEVFRESNGTTGMVVGIVAGAALCILILLYAMYKYRNRDEGSYHVDESRNYICNSNGAALKEKNTADDDSGSKSKKNKNKEYYV", "length": 1470 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A2A7I1-1", "protein_name": "Zinc finger protein 978", "gene_name": "Zfp978", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFAPHQESGRRTTKRMSASLENTAQCLLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFVENHCICGNYEKEKVVEQDTQHIFNEHGHIQEKSFKCNESSNIIHESSESTPHKTNHRDATLQSSNLKRHKTGTTKQVCTYKDCVNCLKGSSIISLNQGTHVEKKEHNRNKNLDEVLVSKHKPIVRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQPSHLSIHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQTSHLSIHRRIH", "length": 335 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A8N2-1", "protein_name": "PRAME like 25", "gene_name": "Pramel25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVICGHCPDQDESLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGHIGILKAMIPEWPFPYLSLGKQINNCNLETLKAILEGLDILLAQKVQTSRCKLRVINWRDHDLNLWAGSHEGEGLSEFTTEKQPIENSPGCEVKKELKVMTEVLRMKGRLDESTTYLLQWAQQRTDSINLFCRKLVIEGLTKASVIEIFKTVHADCIQELILRRICIEELAFLNPYLKLMKRLFTLTLDHIIGTFSFGDSEKLDEEIIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDYLPYCLNICELKHLHLSDICLRDLLLEPLGFLLERVGDTLKILELESCCIVDFQFSALLPALSQCSHLREVTFYDNNFSLPFLKQLLHHTALLSQLISECYPAPLECYDDSGVILTHRLESFCPELLDILKAKRQLQSVSFETTQCSKCGGCYIYDQETQCCHFVELLLA", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A9Q9-1", "protein_name": "MAGE family member B5B", "gene_name": "Mageb5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRGQKNKHHRNRLKNKKHNQEKVHPQKDESQEKGHHKRDDFQDHKEARDNAAVEEKSSCSSPSVPGETLEKPPASKTSSDAGWLSCVSSPATVCGDELEFDDGTYFHCGGNSLYSEYRTCQENPCKHCLDMYVNLVEQYVLYKFKMKKLIDRNKLIDLIEPKYRYNFSDIFKRAFENIEIVFAASVIEIDSTNHVYDLVSKLKLPNKGRVCPGRGLPKTGLLMTILAMIFMNGTSASEEDIWKFLNYMQVYPGRKHFIYREPRKLITQDFVKLKYLEYKQISLSDPPCYRFQWGPKAYTETTKMKVLEFMAKGSGVEPSTFSVQYTEALREENQKTKIRKWYPILAQKHCPGHSHQHVQKVMKPQ", "length": 366 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ADW8-1", "protein_name": "Predicted gene 15128", "gene_name": "Gm15128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANREDEIRQLRYLEAANSEEEYNEENDIQSESSRGQAFFPGHPRGRGHRRDSRGRNGHFFRQRFSANHPLLHLTRQVNLESLTRRNGNQSEERQLQQERIQLFFRSLHGLSQSHDHHIGRSHGHDSRRSRNRFRRAPVQSERSHVYSGRTNNYTDRPQHDLSNRPHNQLSVRPHPDLSGRPLHDYSGRPHQNHAVRLQHGHSDRYHLTHTERVLPNNSGIAHPGHTERDNQVQRGRAHDNQSGLAHHNHDGRSHHDHSGRAYHGHARRAHNNQSWRSDNNQSWRDLNQSWRGQNNQSQRGHDNQSQRGHDNQSRRGHDNQSQRGHDNQSQRGHNDQSWRAHNIRSRRDRYHTSLRSSSIQSWMLHERERYHGPRGRNGPRDASPPGSEPEIDRSSAIRERTDYLWVQEHRRNETVELNVGLEDGYSSAEESDESFDRLTCRSMLDTLY", "length": 449 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AGW6-1", "protein_name": "PRAME like 22", "gene_name": "Pramel22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHRLLREEALAISSLKDLPNMLFPVLFEEAFIFGYTKILKAMIPEWPFPYLSIAVLIDNCNLESLKAVLEGLDILLAQKVHSSRCKLKEISWRDTNHGLDGIRPGSHEVEGLSEFMEQKHPNCVEKKELKVTTELSVMNGRLNESDTYLLEWTQQRKDSIHLFCRKLVIQSLTKATVIEIFKIVNADCIPELELCSLCLEDLAFLNPYLRQMDNLLELTLDHITDSLSIGDSEMLEERMITLVSQLPTFPCLQKLCINDVYFIYGNLKEFLGCLKKPLVSFCISNCELSQSDLDYLPYCLNIFELKCLYIINIHLQYLCLEPLGFLLESVRHTLGCLALKSCNMGEPHFKSLLPALSQCFHLTDVNFQENELSLLSLKQLLQHTSKLTQLSYEMYPAPHECYDDRGVILSHRIEQFCPEVLDMLRAKRQPKDINFVTTQCSKCGIYYVYDLETQRCRFLK", "length": 460 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AGW7-1", "protein_name": "PRAME like 23", "gene_name": "Pramel23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVNSPPTLMKLASQRLLREEALAISALKDLPNMLFPVMFEEAFINGHTKILKAMIPLWPFPYFSLGMMIKNLTLDTLKAVLQEIDILISKVVHSSRCKLKEIKWKNTDYGLQGIWPGSHEFDGLSEFMEQKQPDCGVKKELKVITHLKLMEGSLDECATYLLQWAQQRKDSIHLCCRKLKIQGSINATVIEIFKIVHADCIQELELCCLCLEDLDFLNPYLKQINNLIRLKLDEIKGTVSMGESRNIDEEKVITLISQLPTLQHLEKLCINDVSFIEGNLKECLRCLKKTLEILCITNCYLLQSDLDYLPYCLNILELKCLDFSNIPLSHLFLEHLRFLFERVRHTLECPILKSCEMGESQFNSLLPAISQCCQLTEVNFYDNELSLIFLKKFLHHTAKLSQLTYELYPAPLECYDNRDIILSHRLENFCPELLNILRAKKTAQGGHLCYNPML", "length": 455 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AHC7-1", "protein_name": "SSX member B14", "gene_name": "Ssxb14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVISCEKIPMEVLHKPKNICKAFQDISTYFSGEEWGKLTEWQKSAYMYMKRNYTRMTGVTVNQPVFMSGKEQAKQSLVKGIEVHDSEDECFEESFGVTPRKRMKLTSVTISIHNVEGSLASGENDSNLAETDGIQVNVWSHRLRERKYRVIYSEISDPEEEEDDDY", "length": 168 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AK42-1", "protein_name": "Pre-mRNA-splicing factor CWC22 homolog", "gene_name": "Cwc22rt5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKSSVAHMKQSSGHNRRETHSSYCRSSSPEDRYTEQERFPRDRDYSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRPWKSPSPDRSPARGIRQSSPQEEPTWKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLAQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEEEEEEEEEEEEEEGEDEEGGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYENFFGLLAGRFCMLEKEYMESFESIFKEQYDTIHRLETNKLRNVAKVFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPEAEQKKTALTSSSSESSSASDSSDSDSDSSESSSESSSEASDSSSSSSTQSSTSAKGTRKKRQGKARGEEVDKLARGHQALERRQGGREDQRHQEGRTERARSERHRAQNSRDADWRDSLAKHIDDRSHENSHSRVGNGREQGSHREPEDRHGEPKKKQREKRFFL", "length": 830 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ANE0-1", "protein_name": "Reproductive homeobox 2F", "gene_name": "Rhox2f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSINYLLDVGPEEDEENANGVKTLMVLLAGDGRNEGESGRGLPGSGASAAEGYRAGEISAGGPAAQVADLMDDSNQEDLGATACDQEKEKQPEEPVPDSMGDLENVKRVSGPWSTVNPVRVLVPKFRHLWRHSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ANE1-1", "protein_name": "Reproductive homeobox 3F", "gene_name": "Rhox3f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSMSNWIHSNVEPAGRNLFQVNGHRSALLPELPQDYHRASRSVNGCETKMDNTQGTKVLPAEEARNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEALRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREKYRWYKRL", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ASJ1-1", "protein_name": "PRAME like 14", "gene_name": "Pramel14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLEAPPTLLQLAAQCTVRKEVLTISVLQNLPMKLFPPLFKEADILRKAKMIKLLVEYWPYPSLLVGLLIDKTNLETFQAILEGVGTWLKRKYRPRMGKLQVVDLRNGHHDFWDMLAGREGGDQLVETMPEKQEVEGHSRRQRLRVFSDLSFKSSRHEDKQQTHLLQWAKDREGFLHLCCEKLEIGALGVSKVKKVLKLLQPEFIKELELNTVGNLSKLTKLVPCISKMRNLQKLMLVRIFGRHTYTPLEERNVTKILSLFPKLSYLQHLTIDDVYFLRDHMNELFRYLEAPLLSLTITLCQISQSDLESFSQHWNYGQLKHLCLKGVSLSTLNVTPLKFFLESVADTLQTLELEDCRMKDSHLRILLPALTKCTRLTSINFYDNNISRDVLQDLLHRTANMSQLTMELYPAPVEVYNEWSYVQVERFSQLCAELMNTLITVRRPKSVCFGTYSCYDCDTHCIYGNQTTFCECLE", "length": 475 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ATW2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADIHNVTEFFFLGLSSNQEVQRVCFVIFLFLYMAIVLGNLLMVVIVAVSRNLGSPMYFFLSSLSFVEICYSSTTAPKLIVDLLAEKKSISVWGCMAQLFFMHFFGGIEMFLLMMMAYDRYVAICKPLHYTSIMNRQVCTVLVGMAWMGGFVHSLAQVLLIFRLPFCGPNIIDHYFCDVLPVLKLVCSDTFLIGLLIVVNGGTLTVISFVVLLSSYAVILFHLRTQSAEGRRKALSTCGSHVTVVVIFFAPCVFIYLRPTATLPIDKMVTVFYTVITPLLNPIIYSLRNAEVKKVIKILCTRATKVDKK", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AWL9-1", "protein_name": "Reproductive homeobox 2C", "gene_name": "Rhox2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSVNYKLDVGPEEDEENANGIKTLMVLLAGEGRNEGESGRGLPGSGASAAEGYRAGELSAGGLAAPVADLMDNSNQEDLGATGCDQEKEKQPEEPVPDSMGDLENVKRVSGPWSTVNPVRVLVPKFRHGWQQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AWM0-1", "protein_name": "Reproductive homeobox 3C", "gene_name": "Rhox3c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSISNWIHSNVERAGRNLFQVNGHRSALLPELPQDYHRASRSVYGCETKMDSTQGTKVLPAEEARNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEAPRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREQYRWYKRL", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BED8-1", "protein_name": "Predicted gene, 58953", "gene_name": "Samt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQLIVDTRSVIYRFINEKDCIYKLSGLLSSLAAFMLEVLIASILSWRLWEFDSNVVQFVSFGLFEAYYPQQFNISGTLTKMLVYTPIDSTWNISTEFMYAQNLVVWAILMKPVVLVFCVMAIKISCTKNPLVEMQIYCYKISALILSVSSMFTFVSVIWNHMVDFYGHTTLDFPSDFPVKKEALTSKHLTVVLPVGLLIATMSLFGVIMFLSEISDLKLKRPVKANDASKMGLLDA", "length": 237 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEE3-1", "protein_name": "Spermatogenesis associated multipass transmembrane protein 1d", "gene_name": "Samt1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQLIVDTRSVIYRFINEKDCIYKLSGLLSSLAAFMLEVLIASILSWRLWEFDSNVVQLVSFGLFEAYYPQQFNISGTLTKMLVYTPIDSTWNISTEFMYAQNLVVWAILMKPVVLVFCVMAIKISCTKNPLVEMQIYCYKISALILSVSSMFTFVSVIWNHMVDFYGHTTLDFPSDFPVKKEALTSKHLTVVLPVGLLIATMSLFGVIMFLSEISDLKLKRPVKANDASKMGLLDA", "length": 237 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEI6-1", "protein_name": "Myb/SANT DNA binding domain containing 5 family member 10", "gene_name": "Msantd5f7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQREDNRVQSVRSDKEANRRRRLRQEGQSSSGPCDSPWTEDEIWILLQEWAMVEYELGDPGNKMHAKAKSLSRRLSNRGLRKSKNSCLDVMVKMKDLHTRLCNERPRAYRLYSTYEWILYEILGHPRSQGGYVPGLWFDGHSKPPASYAPSLCIGGAISPGPSFSPWTDPEIKIFLQEWQVVEREIGHPGQKIKQKSSLVCQRLYHRGLFKDIQSCLDLMWTLKDLHSTLSRERSRTVPLFSPYRDYLERIFDPKCQRGHVPGALYNWSGYHRPSSSPQTPMVMPSPVYQPWDYGMSASSGQLHGNPSLIMSSQDSLVPRWDAWNATYPLPVQHVLLASLSGDNNFQLAWSPRDESSSPQ", "length": 360 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEI8-1", "protein_name": "Myb/SANT DNA binding domain containing 5 family member 8", "gene_name": "Msantd5f8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQREDNRVQSVRSDKEANRRRRLRQEGQSSSGPCDSPWTEDEIWILLQEWAMVEYELGDPGNKMHAKAKSLSRRLSNRGLRKSKNSCLDVMVKMKDLHTRLCNERPRAYRLYSTYEWILYEILGHPRSQGGYVPGLWFDGHSKPPASYAPSLCIGGAISPGPSFSPWTDPEIKIFLQEWQVVEREIGHPGQKIKQKSSLVCQRLYHRGLFKDIQSCLDLMWTLKDLHSTLSRERSRTVPLFSPYRDYLERIFDPKCQRGHVPGALYNWSGYHRPSSSPQTPMVMPSPVYQPWDYGMSASSGQLHGNPSLIMSSQDSLVPRWDAWNATYPLPVQHVLLASLSGDNNFQLVWSPRDESSSPQ", "length": 360 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BFR3-1", "protein_name": "Histone H2A", "gene_name": "H2al1j", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKKMQRRRRQKRTHSQRGEFPLSLVDRFLPEGNHSGRLSSSAPVILDSVLEYLSSNILELAGEVAYTTGRKRIAPEDVGLVVQNNEQLCQLFKPGATSVFDPPEPDDN", "length": 109 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BFZ7-1", "protein_name": "BTB domain containing 35, family member 9", "gene_name": "Btbd35f11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BH64-1", "protein_name": "Secretoglobin, family 1B, member 30", "gene_name": "Scgb1b30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLTGALLLLGAALLLTSEGDCGLCPVLQKKVHKFFDGTTEEYVEYLKQYNNDPLVLENAANIKKCSDRMLAEEDKTQATNFINKVTGSRSC", "length": 92 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BHG6-1", "protein_name": "BTB domain containing 35, family member 7", "gene_name": "Btbd35f7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSFGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI40-1", "protein_name": "X-linked lymphocyte-regulated 4A", "gene_name": "Xlr4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKIKGRPPKQPKVTPALPSDDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHLKNLQAIKCCRRKAIIEEARKLMDYLEKTVTEETVHVNKQEAKDGVQSSLLSLLIS", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI45-1", "protein_name": "X-linked lymphocyte-regulated 5A", "gene_name": "Xlr5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNKEQKAMKKSGKHQRVHKTLPSDDFKNSDEVNPADKPAVGTSGMGSHSSGSDMQEAREPVQKKMQDFKGDDGTGLLMEKKKQFEEDVNASFRSLNENLQSILKAQQNSRQELKSLYCERFGSVYHNWLVEMDRTRDQEEYFSFITQQQMKILQTAIEDHETKLKNAKDMCDTFLKKANDLSKRQKTFIGGQHTIVEKEISKVQNRVIMETQDQDISMVETYLQSLIHESSEETI", "length": 236 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI50-1", "protein_name": "X-linked lymphocyte-regulated 5B", "gene_name": "Xlr5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNKEQKAMKKSGKHQRVHKTLPSDDFKNSDEVNPADKPAVGTSGMGSHSSGSDMQEAREPVQKKMQDFKGDDGTGLLMEKRKQFEEDVNASFRSLNENLQSILKAQQNSRQELKSLYCERFGSVYHNWLVEMDRTRDQEEYFSFITQQQMKILQTAIEDHETKLKNAKDMCDTFLKKANDLSKRQKTFIGGQQTIVEKEISKVQNRVIMETQDQDIAMVETYLQSLIHESSEETI", "length": 236 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI74-1", "protein_name": "SSX member B6", "gene_name": "Ssxb6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVSSCEKIPMEVLYEPKNICKAFQDISTYFSDEEWVKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMRGKEQAKQSLVEGIEIHDSDDECFEGSFGVTPIKRMKLTSVTISIHNVEGSHDSGENDSNLAETGGIQVNVWSHRLRERKYRVIYSEISDPEEEEDDDY", "length": 170 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BIM8-1", "protein_name": "Major urinary protein 18", "gene_name": "Mup18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 181 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CEK7-1", "protein_name": "Major urinary protein 14", "gene_name": "Mup14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIRVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CG71-1", "protein_name": "BTB domain containing 35, family member 19", "gene_name": "Btbd35f20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLQPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSVYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKMRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTLKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CG92-1", "protein_name": "BTB domain containing 35, family member 10", "gene_name": "Btbd35f10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIHALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CGC2-1", "protein_name": "BTB domain containing 35, family member 3", "gene_name": "Btbd35f4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQRMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 496 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A3KG49-1", "protein_name": "PWWP domain containing 4C", "gene_name": "Pwwp4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSSEYVLCGWKSQLCPARVLSRPRTPAHSKRRGVPFLEVQILPVGEKRRVRSSKVRPLAKSEIISINSLAGKESRGRGSPGQTRASRRALKVALDGLGEGSSFFQGGRAGSRRTSTLAPKVPKEQASSSSSSLGQRLRLRLRQLLPLSLCQRLHLHLRLRLHLHMHLCLQGRNQKGQGLSQRSPGKRVRPDPGPVMMGSQNVPAVPVGEAQAHTAAGLPRSEVEGDVLRGTRVWPSYSKKTPLGKAGGNPGKRKPGTGKRKLRSLSAPASRKGTRSKTEQQAASGPPRHISISPKALKQRVRCAGLEIRAAGAQRKTALAENKDHPGLGTPKPDSKRASAACMPPVLRLRRSLRIASRKKKTHVLCALCGLPEWEPQVHSKVTNTRFKRRGARVQKDAKATNVVSAQEPSTIEQGTLVWFKFQDLPFWPAVVKSVSKIDKMARVLLIEGNMQFERRGIRVPLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQASYPLRRAVQEGDLHIDFPKVSYAELEDWEEETALGGKGPYKKLLPDRMRAAWDRANQKLVDFIVKRKGADQHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDDDQLHLVARHLQEVAKEADEALLSLARGDKVRFTMEVLFPEAIIYSIAALDELSYKEAEEKYLRGPPVHYREKELFDKTILKAARKRSAARIRAARDPPVPTP", "length": 728 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A5WVZ0-1", "protein_name": "2.7.1.138", "gene_name": "cerk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEKQSTLLCSELSVQRRLYEVTLNCAILAWKDVQNAKKHTGRAIYGAVKAGSHCVPVCEIIAVQEKEDDSPCKDTGKWQKVPQSPTDSCQHAFTVYYVERTRQHCWRCSNVTFQYSEHSLCLLWIQTIKEQLALLSAQSTEELAGVHQPLRRKTTRQADLRPQSGPHLFPGFHFHRRDWPHSFSAHPSELRFYIIADGKEPVMKCTGDCFSPRVQLHHLMQLIDGLHQASRKMQFNCQMNIMMFLPPLYHQPGNNGFSLFVSIVTEHANHARDHLKAEADLKKYDGVVCVGGDGMFSEIMHGLVSRTQQDAGVDENSTEETLIPCGLRIGIIPAGSTDCICYATVGSNDPVTSALHMVVGDSQPMDVCSVHSDDRFLRYSVSLLGYGFYGDVLKDSERKRWMGPARYNISGVKTFLSHRYYEGTVSFLPAEENLGTPRDKVQCRSGCSICRRSSSDKLLSKEDEASVSDVDCRDTWTVIRGKFLAINAANMSCACPRSPKGLSPSAHLADGTTDLILVRKCSRVDFLRHLLRHTNKKDQFDHSFVEVYRVKQFRFTPRFQECGSEMDLRESRAGGKHFFCQICRENRACGCMSSQSNWNCDGEILPHTAIQVRVHCQLIKLFARGIEEQPVFEDLYAHCQLNNPPNHEP", "length": 649 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A5WWD5-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "man1b1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLPSTRKDFVSLTLSESGSYSNSKQWRRQSCWRKWKQLSRLQRSLILLTLMLLLVCGIATSPTLIGHWRGMNGDDVKNSFVVDLKNEYRSILPEPPSERKDFDRRGAFGLEKLLQGKVNVSGVLGDQNHGLDLKNADKGSEGQKPIISWRGAVIEEEQASDTDTKDTENQGDPASLALAESRLEAVREAFRHAWKGYKDFAWGHDELKPISKSYGEWFGLGLTLIDALDTMWILGLQEEFAEAREWVAKELSFDKNVDVNLFESTIRILGGLLSTYHLTGDNLFLDKAKEIGFRLMPAFSTPSKIPYSDVNIGKGTAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDPKYKLAVMEVMKQVHKLDGKQDGLVPMFINTNNGLFTHQGIYTLGARADSYYEYLLKQWIQGGRIEQELLEDYLQAVEGVKKNLLKKSTPLGLTFVGELSHGHFSPKMDHLVCFLPGTLALGVHYGLPADHMELAKQLIETCYQMYAQMETGLSPEIAHFNMHDGSTQDVDVKIADRHNLLRPETVESLFYLYRLTRDKKYQQWGWEILQNFNKYTRVPTGGYTSINNVRDPSYTSPRDKMESFFLGETLKYFYLLFSEDPTLISLDKYVFNTEAHPLPVWPQAE", "length": 632 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6NCW0-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 3", "gene_name": "USP17L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALASGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVGKVEGTLPPNALVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASLQGRTRRAKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NCW7-1", "protein_name": "Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4", "gene_name": "USP17L4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGYYFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATEESTLDHWKFPQEQNKMKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMNSTDQESMNTGTLASLQGRTRRSKGKNKHSKRSLLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NDS4-1", "protein_name": "TBC1 domain family member 3B", "gene_name": "TBC1D3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGRKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NJZ7-1", "protein_name": "RIMS-binding protein 3C", "gene_name": "RIMBP3C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH", "length": 1639 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A7TZG3-1", "protein_name": "Selection and upkeep of intraepithelial T-cells protein 9", "gene_name": "Skint9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSASCLPGFFMSFLLLQNTVLTQAMRSDIKINIQVPDTEGLLLECTSGSLIPPAEMTWRDSNGNIIPHSTAFNSQDRDGLLYLKSSILLKNRAKGPITCSIYNVTTNQEKKRSIVLPDALFKSENMSLMSNKFSCPSIYLITIIFLNFLRGILVFCCLRRKPVCFRNLMSTVMEALYSKMGVCCLLIWECLLLVLYIAFLPIYVSFRSRAFLLDDTYPLYTNWLWNICIILTVIMVLFPGLILCLLWTLNCYGQVSSLPPTSMELSTKDSEQNSSKSDDSQENYDVNCKILETCESKIFSQHQESCEDDTASTLFIS", "length": 319 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A7XV14-1", "protein_name": "Selection and upkeep of intraepithelial T-cells protein 11", "gene_name": "Skint11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPSASCLPGFFMVCILLKITVLTQVMSLDIQINTQIPDTEEGVLVECTAESLFPPAEMTWRDSKGNIIPPSSTFDSQDRAGLLCLKSTILLKNRTEGPITCSIYNKTTNQEKRRSIILSDVLFRPQYMSLMSNNLLYLGIYLIFILFLNFLKGILFCLTKRLVHFRKRMIKIKKVWSNKTRACCPLIWEFLEIVLFIAFLPLYLMFRIRVFTLDEAHILYNNWLWKVCKTLIAMMILFTVLILFLLWTLNRYGKMPCLSSMNIDVSTHDAEQNSSKSAKFQENYDVAGQMILETYEETIFCQHQESCEEYNYDPLLLSSLDALGTCEDEKFSQHQESFEEDEDLQSFSDFKIELYSKLGNLTH", "length": 364 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B0BMZ6-1", "protein_name": "Cilia- and flagella-associated protein 119", "gene_name": "Cfap119", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MITPRSSQSLEMKVQTELEHSPKLQEEPDRSPSLVDSSVIRIGTDEQNESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEEMREVLAELLELGGPEQSLRDAIILDLFSHALIFCRQQGFSLEQTSAACALLQDLHKACVATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLSYMGLQSLHLWPEEKEDEEATVEQAATPQEEEPEAVTEAEQQPSEVCILQTYIKCQLNKELRQLQQLVEERLKESEERLSNRLAALERPYQTPPSKGKSKAK", "length": 332 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0G0Z9-1", "protein_name": "Probable polyketide synthase 6", "gene_name": "pks6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNLKNIDLIEKGVAIVGIGFRIPSGNNENSICSPDDLFNNLKNGFDGVSSTSERWSDNYHKLGEISSPNAGLLPLNEWKSFDPLFFGINPSEASLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGASNIDYQHTNKHQDSVLKNAIAQSTCAISNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSDISIVGGVNLILDVEMTKAYSYLSMLSKTHGKCKAFDESGDGFTRGECVGVVVLKNLQDAIKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNDKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSAPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRNNEKPVSMMINNFGVTGSNCCLLISEFKNNNNFKENINLESQSVNDRVLIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTAIQIYSKSNYLYQRSVVIASNSNELFENISNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGFSVWEKVKTIKDDDLTSIHDPIFAQPALCMISVSLFELYYHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYQRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQSTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLDNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNLNIELPLYQWSDELYFAQNQVLEQHRKGGPPIDHLGLSNSYYSPFKNSYKTLIDINYKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDHKSNEWIQSSNSNFQLLDHGNDIPSNYNIKEIIKNKCNLSKLTKNELYKNIKSKTGLNYTGVFQGVTECYIGDNCTLSVVSLESQTNSFLNIPILDTCLHGMLILINDQCQIVFDKAIGFKYYSSNIPADFKENKDSFYVYSNLRPRVGGDSYHGTIIVMLSDGSVLYEIEEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSPIPTPSSFKSIIYENDFFQSSLNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSFEEKDDTYFEFNKVIIKSSRIISKLLFPLENDNDNEDLPQSLFQNGLMDKIYKCSYLRKKNQVISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIVTLLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYHPLTIGESLIETQSIKPSYYDFVIMSNVLHVVKDIKQAVEQMYQLLTTNGQLVFLEPPYKSVLNDSIVGSFEQWWSFTDTDIRKDRCGMPQQSWYQLLNSCNFKDIVMSKECIFFGSVIQAQKPPISLLNSQPKYDNIIIYGGSINSSFVENIKLDSNSKSLFQIETIQEFNKLISKSTITNDSIVYFIKTLETLSLDNFKQITLEYIEINQKLLQINSLCKHVLIVSDSRKTNYLASSAIGAARYFDEFPLLKLHTLDFDYDSTQNYINSKNNKMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKKIQIKPSKISHIEASSIPIDYLTSFMSLFNVGSLNIEDNESILIHLGRDGFGLSTFEILKWKGFKSNLFVTVNSDKTKQYLLKKYGDLITGIYSNTDKSYVAEIKNKLIKLGSKKKGVDLILNTLPSDFMDSNFKLLTKYGRIIDLNSNHLNQSEFLKNINFKYNHGYHNFELSLFQKNKILKCLNEISNAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRYLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINDILNENQQIRNIDSIFHFAFQQIACKVQEINMKHLNISHGAKSMGAINLHNQSIKRNWKLINFVMASSALSFIDSTDQCTYACANTLLDSFSKYRVSLGLPSTCINLGLIESTGFVSKNESISVFLDGNGIIPTPINRVLGLLDLQIQNASKFTNSMISNFKPSKFKNNQQISLFLKFDYLMNLKNNSEQTKKENTGNKNIDELFIEKVSELFSMDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTINISIKMILNSLMKNNQNKYLPSNRIDYWKNEMKFEESIKPIPNEIRSRNNNSGKIILLTGTTGFLGGFLLFNMLRLDSCKLIYCLIRNKSKSSYPLDEIINNLKYHQLYEKLNKSQISKIIPIIGDLSMNKLGLSNDDYETISKNVNLIINPGADINQKSSYQDCKLVNVNGVKEIIKLSLSSLKQRIPIVNFSSFSVFFNQSLDKNFDESVLPSIDNIDNLPTEYMKSKVVGEYILLEASKNYNIPSILIRPPSIFLNPETGIGHSSDLTLLMIQSCYELGYCPNQILNGFILINTITWLSNNITNIIMNDNCWTNSKMNIYNVHGKQIQSSLIIKPLEKHFNCKQINNNDWIDMVNNSNKKSCIKLKSFHSLENIFKSENKGYKSNESQSISLSTKSLLESMGSYNTDLKITDKMIISHIKHIFK", "length": 2924 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G100-1", "protein_name": "Probable polyketide synthase 7", "gene_name": "pks7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNFKNINLIEKGVAIVGIGFRIPSGNNENSISSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFNECKSFDPLFFGINPSEAPLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSNIDYLHTNKHQDSVLKNVIAQSTCAISNRISYCFDFNGPSLSIDTACSSSLNAISQGYHSILNGTSDISIVGGVNLILDVETTKAYSYLSMLSKTHGKCKAFDESGDGFTRGECAGVVVLKNLQDAVKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNEKLSVNEIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNRKNEKPVSMMINNFGVTGSNCCLLISEFKKQDYEPYENNYKSNNKNILIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNYLCQRSVIAASNSNELFEKILNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLINSKLSKYYGYSVLEKLRSIGDDDTTSIHDPNISQPAVCMISVSLFELYCHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYHRSIAQTKTHGNGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSVLKLNIQSNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIINPVRFTQTISNIYKHIESNQLNNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNKKIDLPLYQWSDETYFAQTQTLEQHREEGPPIDHLGISNSFISPFNNSYKTLIDINNKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQCLQTNIQQTGKSEYRAQFHFKDQKSNQWTQSSNSNFQLLDHGNDIPSNYNIEEIIKNKCNLSKLTKNELYTHIKSKTGLNYTGVFKGVTECYIGDNCSLSVVSLESQTNSFLNIPILDTCLHGMLVLINDQCQIVFDKTIGFKYYSSNIPAYFKENKDCFYVYSHLKSKSADSYHGSIIVMLSDGSVLYEIQEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSQIPTPSYFKSIIYENDSFHSIVNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSLEENDDAYFEFNELVIKSSRIISKLLFPLENDNDNEDLPQSLFQNGLMDKFYKCNNFKKKNQIISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIGEIVTLLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYLPLTIGESLIETQSIKPSYYDFVIMSNVLHVVKDIKQVVEQMYQLLTPNGQLVFVEPPYKSILIDSIVGSFDQWWSFTDTDIRKDRCGMSQQSWYQLLKTCNFKDIVMSKECIFGSVIQAQKPPISLLNSQPKHDNIIIYGGGNNSRFFENIKLYSNSKSLIQIETIQEFNQFINKSTITNDSIIYFIKTLETLSLDNFAQITLEYIEINKKLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLHTLDFDYDSTQNYINSKNNKMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKNIQLKPSKISHIEASSIPIDYLASFISLFNVGSLNIEDNESILIHLGSDGFGLSTFEILKWKGFKSNLFVTVNSDETKQYLLDRYGDFISGIYSNTDKSYVTEIKNELIKLGSKKKGVDLILNTLPSDFMDSNFELLTKNARIIDLTSNHLNQSEFLKNINFKYNHSYHNFQLSLFQKNKIQKCLNEISNAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRYLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSIDVGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAINLHNQSIKRNWKLINFVMASSAISLIGSTDLCTYACANTLLDSFSKYRVSLGLPSACINFGSIESTGFVSKNESVSVFLDGGGFHPTPINQVLGLLDLQIQNSGKFTNSMLSNFKPSKFKNNQQISLFLKFDYLMNLKNNSEQTKKENIGNKNIDELFIEKVSELFSTDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTINISIKMILNSLMKNNQCGREI", "length": 2513 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G101-1", "protein_name": "Probable polyketide synthase 8/35", "gene_name": "pks8", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNLEIINLIDKGVAIVGVGFRIPSGNNENSICSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFNECKSFDPLFFGINPSDAHQIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSNIDYQHINKHQDSVLKNVIAQSAYAVSNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSNMSIVGGVNLILDVGMIKAYSYLSMLSKTHGKCKAFDESGDGFTRGECATIVVLKNLQDAVKDGNRIYCVINGSSSNVDGGGHMDKVNLYSPSKQSQFNNINSAFKSTNGKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRINEKPVSMMINNFGVTGSNCCLLISEFKKQDYESYENNNNNKSNHKNILIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNYLYQRSVVIASNSNELFEKILNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNDEIFKKSIDLIDSKLSKYYGYSVWGKLTTIKDDDLTSIHDPIFAQPALCMLSVSLFEIYCHWGVNPSFILGHSLGEISAAYCSGMIDLDTFCYTVYYRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLNNDIVFIEIAPHPTISFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYSINFKCQLENKKSNQSINLPLYQWDDELYFAQTQTLEQYTKEGPPIDHLGLSNSYYSPFKNSYRTFIDINNKPFQYLKGHMVKGKYYFPGCGYIDIIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHGNDIPSNYNIEEIIKNKCNLSKLTKNELYTQIKSKTGLNYTGVFQGATECYLGNDCSLSVLSLKSQTNSFLNIPILDTCLHGMLVLINDQSQIVFDKAIGFKYYSSNIPSDLKEYKDSIYVYSNLKPKNADSYHGSIIVMLSDGSVLYEIQEVIFKSLIPIKHSLKIEYPNDELYKVHLQSKDSQIPTPSSFKSIIYENDFFHSALNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKNQRLFRFVFETIKENGILNSLEENDDAYFEFNELVIKSSKIISKLLFPLESDNDNEDLPQSLFQNGLMDKIYKCSYLRKKYQMISHVIIHSIKEIINNNIIIRILEFGGGTASLSVEVIGEIVALLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYRSLTIDESLLENQAIKPSYYDFVIMSNVLHVVKNIKQAVEQMYQLLTPNGQLLFIEPPYKSVLIDSIIGSFEQWWSFTDTDIRKDRCGMSQQSWYQLLKTCNFKDILMSKECIFVGSVIHAQKPPISLLNSQPKHDNIIIYGGGGNLSFVENIKLDSNSKSLIQIETIQEFNQLLSQSTITNDSIIYFIKTLETLSLDNYKQITLEYIEINQRLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLHTLDFDYDSTQNYINSKNNKMVQFINILVDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNNNNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKNIQLKPSNISHNEASSIPIDYLTSFMSLFNVGSLNIEDNESILIHLGSDSFGLSTFEILKWKGFKSNLFVTVDLDETKQYLLDRYGDFITGIYSNTDKSYVTEIKNELIKLGSKKKGVDLILNTLPSDFMDSNFELLTKSGRIIDLTSNHLNQSEFLKNINFKYNHGYHNFQLSLIQKNKIQKCLYEISHAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRSLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAVNLHNQSIKRNWKLINFVMASSALSLIGSTDQCTYACANLLLDSFSKYRESLGLPSACINLGSIESTGFVSKNESISEFTDGIGYVPTPINLVLGLLDLQIQNAGKFTNSMLSNLISSKFKNIQQTSLFLKFDYLMNLNDNSEQTKKENIGNKNIDELFIEKVSELFSTDQSRINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIKQLQNNTINISIKMILNSLMKNNQI", "length": 2514 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G110-1", "protein_name": "Acyl-coenzyme A oxidase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKNRIEIIKKHLEVNNSQTTNNKDEVLEKELFNSIDTNINVGELKLLIDSVEESKYKDETREFIRNHPKFKENFIGLDMATYRQLVLEQCAAIANRGLIHFTDIKNNLHRYIGALEMFALYNNNILTKLSVQYTLFGGPIIFLGTSRHEKYIEDANTLKTMGCFAMTEIGHGSNVRGIETTAHYDKQTKEFIIHSPTPTSEKFWIGCAYLHATYAVVFANLIIDGTNYGIHAFIVPLRCPKSGAIMKGITIKDCGHKLGLNGIDNGQIRFDQVRIPRENLLNKYSDVSEDGVYKSQFNTPIKNFAATMSPFIVGRMAITKGCSGAAKTSLSIAIEFSHIRKQFGPSSNKELPLITLSSQQRRLMAPLARTILFDLYIQRLTNELCQEKLPASIHAHCSGIKAVYSWFCVAALQTCREACGGQGYRSANRIAEFKNDCDIICTYEGDNTVLMQQLAKYLLGVKQKQTNTTTNRIYLDGEDAKSLFFNFSNINQLFETREEMRLAELKQIIDNSKESAYFAFNNAIPWAVKLGFAHMTKIVFQNSINTLKLKNVKPLTHLIMLDALVSIEEDLGWFVSNHLISPNVAQSIPFLIQDLCFEVTKVSKQIIASFDIPENCKPSSKDLISDLF", "length": 629 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G138-1", "protein_name": "Probable polyketide synthase 21", "gene_name": "pks21", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLENKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSIAMGFQSIQNGTSNLSIVGGVSLLLDPYISKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSKTSTPSKPLLIGSLKSNIGHSEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNNNEKPVSMVINNFGVTGSNCCLILSQFIEQSINQNGNGHSYPAESQQQQQQRFLIPFSANSVKSLKNYEDLIINDIKISTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTNNDKSSNITIKRNQPLVVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLNLKENNIFCAFLGSLSSFHTSSQHSTKNEILPLDIPSKQSRIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDVNFKCQFNHNDDDVSSIRNSKVNISLPNYQFDEQHYWKVDINFEQYRLNGPNVFNSLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNQDIIINNLEFLAPFVLKENVKHTLQTNVYQLGNTDYRVTFNIKDNKTNQWVQTCTGNFQLISLKDNNNDHSSKYDINQLLSECNFTTLSKQEVYKHSRSITGITHLGAFQGIEELYFGNDCIISKIQVNTENFDIDGKPVYQTYDKSFFNTALLDSCSQTIVGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLESDSYKSSVLVLLEDGTKLLEMDCISLHSTLPLLNSLLINNPTTELFTNNLQCKDSLVNILSIDNNQTFSSISSSNTVTEIIKQTIKPIINEKIVFRILQSFSDLELSKQIIETLNQIFDDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDGDDETIIKSIFNILSSNGLLLIIGDDIGDKYNIDSLINLGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKESKYTNEFMKLISNNHISCKQTIISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGTARYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNQIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISNENQNCEFKVGDNVFGIACDTTASHVIADVLYVSHKPENISHVEAASLPVIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIELMHINKKVVSRLLKSISNALNENKLKPIPITTFQIEDVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKSVDVGDPIEMRKSINQILLENPNIDNIDSIFHYAFAQITKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCSYVSANLVLDSLSRYRKSIGLPSTCTNWGAIKSAGFVSRNELVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKNSNLIVSKFNYDSIKKLSSETSTFQRLDFILNSIKEKDNDSNGGENSVSESIQTKILNKISELLSIEQSKINTDIRLSDYGADSLTSVQLKNFIDKDIKSNVITLQQLQNNTIDMNIQTILEQIKKLDSNETKGKSKNIIKKDSAPTLDYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKIKVIVGNLASPLLGLSKLDFDYISNQINLIINSGADINLASNYEESKVVNIGGFIELIKLSTTGDYQKPIVGFSSVSVFFNASNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLLREVAKRGIPSMLIRPPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPKIDKNILTSPIGWISLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSAMNPSFSFLEKQYGCEMVEYEQWKNIINQSKILSCVKLKTFHSLDDLYNIYNLGNGFGVSKKTKELLQSMNSYEGGMVNEKMIQNHINYIFKN", "length": 2779 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G149-1", "protein_name": "Transmembrane protein 184F", "gene_name": "tmem184F", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSHINIIYIIWILLFFFTCLISFFLVNRHLVNYSSPNVQKNVVRIVMFLPLNSGLSILSSIFPGIAIFNSLVRNCYMAFTAHCFFSMMTNSIGEKNMLDLFESQGKMKFLCCKVMKLNRKLFNTLRFGSIQFFIVKIFCSIATITCISISEEVHSILNVQSFAPYEFLISLVASIFCTISLSIFLAISKEKLSQYWPMTKYRIMIFIFFIEQFEYLFFALIFLRGPFFLGFKNSFDQTIFILHFTVVVTMFLFSIVYLFIYSYKNYRNKASNEPLVGRNFKDSFGLLNYLDVLNPKDLFIDFASIFKTNNNKFKELVEENGDKKPKKNIEDQNQENSNDQPLSIQMA", "length": 348 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G188-1", "protein_name": "GATA zinc finger domain-containing protein 16", "gene_name": "gtaP", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSYQIQNQPYQQIQNTHPSFQQVQPMQVPHLQQQQQHQTMIAQQQHTPPQQHTPPQMNMIQQHTQPMLSQPQISLQMQPPSPILASQQQQQHMQSSPILASSNLTNSNNASQTTLPIITSKLLLKKEPIDQEVVNSTHKTTTTNNKPPKQSKRKEKERLEEEKQTVAQQQQYQPPFIPLASNESNSDNPFKGSHAYGVSTTPYGNSQFNNNNNNNNNNNNNNNNSNNNSNNNNGNNNINNNNNNSNNNNNNNSNNNNNNSNNNNGNNNNNNNNNNNNNNNNHNTNNNNSNSNNNNNNGYQQDKKDDYSMMIWSEVGRKINILIRTTSKATKGTPISTQEIAEAIGASNGVTADLVELIKSINDPTYVRKLPPSSISNTPTMGSQSGGMVYNSSPMLSPSTMSPILQHGNYQMGGDMYFGGNNQFSGDKQSALNNVKNSKGGNTNNSGGGSSSGGTNDTQAKKPARRRKMRYGGTELSCHTCGVTNTPEWRRGPNGAKTLCNACGLAWAKSVKSEKQKELLANSTGVNITEPKKAQKRKKESSDNNNNNNNSSDSNKVLKSDDGSNNTNLTNDDDNGYPSSPNSSNSTSPSSHNINNNNNNNNNNNNNNNNNNNNNNNNNNNNIGNNNNNNINNNNTTNSITTPTTTPFPTTIPAMQIVSQLPVMVPQTQQQPHMSGNIISFQALHQNSGYQHYK", "length": 695 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0R191-1", "protein_name": "C-X-C motif chemokine 11-6", "gene_name": "cxcl11.6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKTLAAFLLLSCLIAGEVNGQDRSSRARCFCVDKGLNMVLLKNLDKVEIFPPSPSCNKHEIVVTLKNGAGQKCLNPDSKFTKNVVLKAIGKRMQQSVPHSTTTGTVKSSMTSSTSAPTAFK", "length": 121 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B1AV09-1", "protein_name": "Leucine zipper protein 4", "gene_name": "Luzp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANHEDEIRQLRYLEAANSEEEYNEENDIQSESSRGQAFFPGHPRGRGHRRDSRGRNGHFFRQRFSANHPLLHLTRQVNLESLTRRNGNQSEERQLQQERIQLFFRSLHGLSQSHDHHIGRSHGHYSRRSRNRFRRAPVHSERSHVYSGRTNNYTDRPHHDLSDRPHNQLSVRPHPDLSGRPLHDYSGRPHQNHAVRLQHGHSDRYHLTHTERVLPNNSGIDHPGHTERDNQVQRGRAHDNQSGLAHHNHDGRSHHDHSGRAYHGHARRAHNNQSWRSDNNQSWRDLNQSWRGQNNQSQRGHDNQSQRGHDNQSRRGHDNQSQRGHDNQSQRGHNDQSWRAHNIRSRRDRYHTSLRSSSIQSWMLHERERYHGPRGRNGPRDASPPGSEPEIDRSSAIRERTDYLWVQEHRRNETVELNVGLEDGYSSAEESDESLDRLTCRSMLDTLY", "length": 449 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AY40-1", "protein_name": "SSX member B8", "gene_name": "Ssxb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVSFCEKVPMEVLYEPKNICKAFQDISTYFSDEEWGKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMSGKEQDKQSLVEGIEVHDSEDECFEGSFGVTPIKQMKLTPVTISIHNVEGSLASGENNSNLAETSGIQVNVWSHRLRERKYRVIYEEISDPEEEEDDDY", "length": 170 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AYI3-1", "protein_name": "Predicted gene 13272", "gene_name": "Gm13287", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVHLFLVGGVMLSCSPASSLDSGKSGSLHLERSETARFLAELRSVPGHQCLRDRTDFPCPWKEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSCPLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQLQVDLPAFPLSARRGPR", "length": 182 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AZM5-1", "protein_name": "Predicted gene 12886", "gene_name": "Gm12886", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLPCSLWLLSVCLLSWCCDAKLPVALDPESESVPKPPVLKTATEIAAIVVFMKTSNETPKSGTYGQSLQDGKNKIKDVEKEVLDACSQLCQSLAQDPNLHHGYILRAYFKEHQFLCCF", "length": 119 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1B0R2-1", "protein_name": "Spindlin family, member 2D", "gene_name": "Spin2d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSKLTKKRAGRKRQRSRSPALPKRNIVGCRISHKWKEGDEHITQWNGTVLDQVPVNPSLYLVKYDGIDSVHALELYKDKRVLSLKVISKRVVSSGVTDSSFADAIVGKEVNHLFEGEHGSKEEWRGMVLSQAPILDNSFYITYERDPILYTYQLLDDFKEGDLQIMEGFSDPPSLDIDLELVDGLIGKHVEYTNDDGSKRDGLIIYQIETKPRVYLVKYEDDVHIHVTHLEKEL", "length": 236 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B4F7F0-1", "protein_name": "Claudin", "gene_name": "Cldn6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVITLLIVLLGLLLYLAGAKCTTCVEDKNSKSRLVLISGVIFVISGVLTLIPICWTAHAIIQDFYNPLVADAQKRELGASLYLGWAASGLLLIGGGLLCCACSSGGTQGPSHYVARYSSPVPHSRGPSEYPSKNYV", "length": 219 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B7ZW38-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein C-like 3", "gene_name": "HNRNPCL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASNVTNKMDPHSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKEKNARAAVAGEDGRMIASQVVDINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYNLQRDYYGGMYSFPARVPPPPPIALAVVPSKRQRISGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDLQAIKQELTQIKQKVDSLLENLEKIEKEHCKQGVEVKNAKSEEEQTSSSSKKDKTHVKMESEGGADDSVEEGDLLCDDDNEDQGDNQLELIKDDEKGAEEGEDDRDRANGQDDS", "length": 293 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B8JKF6-1", "protein_name": "BTB domain containing 35, family member 13", "gene_name": "Btbd35f13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRFLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGAINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD1-1", "protein_name": "Spermatogenesis-associated protein 31F1B", "gene_name": "Spata31f1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD2-1", "protein_name": "Spermatogenesis-associated protein 31F1C", "gene_name": "Spata31f1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD3-1", "protein_name": "Spermatogenesis-associated protein 31F1D", "gene_name": "Spata31f1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HLM6-1", "protein_name": "Small integral membrane protein 20", "gene_name": "Smim20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAARNLRTALIFGGFISMVGAAFYPIYFRPLLRLEEYQKEQAVNRAGIVQEDVQPPGLKVWSDPFGRK", "length": 69 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "C7G009-1", "protein_name": "Thioredoxin fold domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLILNGNWLVKFGAGWSGHCKKLQPVLENLAQHYNSDNENSKVKVAQVHCEEYESICIKYNIIGYPSLVFFDEGEIKHYRGPRLFENFKEAIDKHLNKEFVAFSQNQPSKIIVITNENLDLLLTGNWLVKFGAAWSLHCKKLQPVLENLAQHYNSDNENSKVKVAQVHCEEDNSICKKYNITGYPSLVFFNEGQIKHYTGPRQFENFKEAIDKHFKYGVKWSGHCKKFQPVLENLAQHYNSDIENSKIKVAQVHCEGDDSICKKYNITGYPSLVFFDEGETKPYRGLREFDKIKEATDKHFK", "length": 303 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C7G010-1", "protein_name": "Calcineurin-like phosphoesterase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLKIKFSIISLFILKLVISKPILKFNNNNQFKIIQFTDLHYGSEPVDDIDTIFSQVNILDYEKPDLVILSGDMVTGYEEQFEDDDRNYWKYWNVFTRPFVERNIPWAITFGNHDGEGALSTNEILKIDQTFNLSLSQSNPVEMHGIANYVLKISSSNSLKSEPASLVYIFDSSTKGCSKLDWGCVHQDQVDWFKNTSKSFNKTDSIAFVHIPPVEIIDLWNNYPVYGNYSETSCCFDNDYGDFVSSLVESGDVHGLYFGHDHENDFHGDYKGVDLGYGRKSGAGSYSSKKPLGARVFQLTESPFTLSTWIREEDGNIVSQVIHPPSEFDRKPLQCKMKDKYSKKELIAIKVIGGFLIFLGIVVVGLIGFFGFKHYKKFKKQTLEMQNLV", "length": 390 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C7G064-1", "protein_name": "SET domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKKDEKQFQQFPNKGRTVQANTDLPKGSTVFRCAPFASSIEDSDKLATEKYCGFCLQRIPKSDSKECLCKNCKLYSVCKSCRSINESAVEPFQIIIKSTFHLGSDTRDMRLLLRIIANIANGKQGMQTPIDDYQDFMGLTSTLDKVDKEHMTKFKRGVTSISSLISSVRGVGYLKNTITIHEILECFSSVLTNAHQFSYATSKEIGRGVCPTGYFNHSCMPNTTWSLDDQGMLLFSTSSNVKKGDELSLGYLANEYPLKNRRRELLDGYYFFCQCPLCEFQSNLSGYLCEKCKEPLLNDSIVYHEPSLTNPLDTGIGLIKHLRKMIDFRQQSVEFKKMFSSEQLSNILQKGVPKHIQSVFNCDASDNEELQQIVEISERSIKSLPLINGEPIDFYPLSDRNYYEYFKQLKNSKISSPEELQRIKDKILSLINPTIYNSFKDKIDKRLLI", "length": 449 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C9JPN9-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 12", "gene_name": "USP17L12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLKLSSTTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3YTW8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r258", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVRGKSLKTTEEVALQIILLCQFGVGTMANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTVFPNNMMAFAPRNPPTELKCKLKFFSHLVTRSTNLCSTCVLSIHQFVILVPISRGKLLLRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSKFFCSTSGFTVRIVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQQMQHILTPNQDARGQAESRATQTILIVVVTFVSFYLLNFICIIFHTFFIHYNLFIRLLGEILAAGFPTISPLLLIFRDPKNPCLELFHCFKPESLQNL", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTX5-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r259", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTY1-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r107", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLDFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTY2-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r138", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPLSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YXI8-1", "protein_name": "Predicted gene 10377", "gene_name": "Gm10376", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQAGSFRKASPQTPNIDENEKRIKRLEKLKRDLQNIKNERDILQGILAKYKDLNDRTNFETFMLEMQNNQMMTDLKRMSQDISEALYKCQHLTKENQLYCCRNCHLLIESNLIQHKVRMLWKENRQLLRKQIALEECNIKTKILCKEGSQKIKDEYSRQAAGKQIIVVPGSKEEAVMSNPCA", "length": 184 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YYI9-1", "protein_name": "Predicted gene 7347", "gene_name": "Gm7347", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTKETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YYY1-1", "protein_name": "Secretoglobin, family 2B, member 7", "gene_name": "Scgb2b7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACFPFFEAYASVLSGSRVWLYQELQAFDATAEEKVALEKIQDCYSEESIRNILLEPKIMEAMVASPECLSYYGLDNIRSILDYISKLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3Z236-1", "protein_name": "Predicted gene 3676", "gene_name": "Gm3676", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQTVSFRKASPQTPNIDENEKRIKRLEKLKRDLQNIKNERDILQGILAKYKDLNDRTNFETFMLEMQHNQMMTDLKRMSQDISEALYKCQHLTKENQLYCCRNCHLLIESNLIQHKVRMLWKENRQLLRKQIALEECNIKTKTLCKEGSQKIKDEYSRQAAGKQIIVVPGSKEEAAMSNPCA", "length": 184 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3Z8D1-1", "protein_name": "SIGLEC family like 1", "gene_name": "Siglecl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWGLRSLLLLHLGFLSPVLVDTKKTAVEDGLCSTVPCVIEFSKAPLRKPMIVSYRLNENISFHAGTSQPRGPVADLSTEEVEYCILLTHNMLGRKNMTYSLYVGLGAQKDLTQKQELHIPGSSMAGEPVSLTCTIHSTCQESKALFLSWKGPIMSSSTTVPINPSSALAIDPKPEDQDTTLRCHLKLSLDNLSSSKVVKLQLVSPARLLNYSCLLKRTLTCSCSFHGIPTPSVQWWVGRTPVSVNSIDAILHMTSTTLESWTNSTIHLMWEPEIIKSLRCEGKNQYGVHASGIFLIPDKSSVSSVFLRGLIQGIVYGAIASALFFFFLVVLGMKILNWWEENQTCKNEEAPTLKKPVWGGAKPAEVGS", "length": 369 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3Z8T0-1", "protein_name": "High mobility group nucleosomal binding domain 2, pseudo 3", "gene_name": "AABR07053402.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKRKAERDAQGDEAKAKDEPQRRSARLSAKPAPSKPKKAPAKKREKIPKRKERKADAGKDANNPAENRDAKTGQAQKAEGAGVAK", "length": 86 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3Z9U8-1", "protein_name": "S100 calcium binding protein A7 like 2", "gene_name": "S100a7l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQNLTSSEQEVMKLFDLFQNYHVRRTDKLDVQETKRVLREFFPNFMKALNASGIKILNDLEKEITLDEIWDMIGRMAMAYNKKNSNALKD", "length": 91 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZAM9-1", "protein_name": "Olfactory receptor", "gene_name": "Or4f60b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKKVNYSVTSEFVFLGFTNSWDIQLLLFLVSSMFYVACIMGNCLIIFTVASDTHLHSPMYFLLANLSFIDVGISSATSPKMISDLLKKHKVISFRGCVIQIFFNQAIGGAEMVLLIAMAFDRYVAICKPLHYLTMMSPQMCLFFLITAWVVGLMHSVIQLIFIVNLPLCGPNILDSFFCDLPQFIKLACMNTYRLELLVSISSGFMSLVSFFLLSISYIVIILTVLKHSSSGAYKALSTLSAHVTVVVLFFGPAIFFYIWPSSTHLDKFLVLFDAVVTPFLNPVIYTLRNKEMKRAMRRVFRHLMGYRQIS", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZC26-1", "protein_name": "Ferritin", "gene_name": "Fthl17fl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEASSQVRQNYDRCCEDAINNHIRLLLQASYSYLSMAFYFDRDDVALGNFKRFFLSKSHNCKASAEMFVFMQNKRGGHVFLPSIAKPDRESWHGGLRAMECAFRMEMTINQSLLNMHELAKGKDDAHLCDFLGQHCLDQQVHVLKKMGGYLTNLRQMGAPEQGLAEYLFDKLSLS", "length": 176 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZCM9-1", "protein_name": "Dynein axonemal assembly factor 3", "gene_name": "Dnaaf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTPAGSGNGFGTVSWWGLSPALDLQAESPPVDPDSQSKTEHKIPELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLELWGNALLRPSVAAFLRAQASHLSNLVPEPDRLEELLPWLSLRPLKFRERDALEAVFRFWSGGEKGPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRWRDTGVAFELRDLSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHNVTELFRDVAAWRGPRAIKGNVEETKSPEPDAPAQEPFTIHFLPLDSSQTLHHKTCYRGRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAPLKHVT", "length": 583 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZCW3-1", "protein_name": "SPATA31 subfamily E, member 1", "gene_name": "Spata31e1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METFLLLMNSISDFWMSSSSMSTVMDMIFAILCGVGFFFLLIPFLKEYPGSPPPGSKKNISEVVKRRQSKDRKKSVTVDGCRDSQKNSLDIQHDLQTMESPIQHLLLDSSPHPFWNSKEKLNQLSLPQLFSYLKVLEALIQQKFNQLLLGLSSVLSESVVATAWVSREPSSGERKTVRFSDSLGFDQALPLAKGPPQRCLDQPLPHQLVTPSLVGMTEIQEQENLPNSISYQTPSIFQSRARGTAYPTTATGIQVPLPTTNEPCHPGLNWKDIPSCKVQNCQGASSQPTESLARCTLPTKNTRSASIPPEHYLMVHHHEQPQHEEKAINLGEQQRTHARFLPSKEPAQLQGDSPPNSNGYGKNWPELNQPAQPSTLNSKTYKWNQMMGPVPTGMLLKKVIAKYGIPNTIKKDLKLRVKDLLCTSSSTPGESLETKNLTLRTDEHSMNTTENLSFLDPKTTMMKSNIMQLPMKHRQLPCDSKAEPYTKAAFILENLHHQDPGGIRVETASSARLRSPLFEQSPPEVQKTQSSPPPIDSHGHSRSHPDQWQRYQSVQPHALCSQAQPQQSRSIQGTGRSILQPNISVWMSKHERWMRSEDVASGHTSWSSRTVGYRDRVSPSVAKQTNILKIKEESPHVWRANLGSGEITNEQALNNSNEDFEPIEAKRSQGHLQMPTQQNTGYLHLKTEEYSNNDLKVNKQPQAWSVSHHADGSNTVHHAMVKLPSQHSLPSLQNGWQDPKTSQGLGDLLMNRDQSVETQFRVHKDKTEATNDSVFHPSEKRPSNLKYGGISQGERLGRVKSSISSFTQLKDSAKTESKSSPNIGGKREAPSKSSLKFIWNGAQYENLSTKLKGQRDSLKKDIPPPVTEQTQEVVHRINVIYSTAVELQSLMDSLVHKLVKTVGEPSELTRKHMTKVQEYKMESLPFQLGSSSQPSKGLHDPNKSRSVRRMSDDHTSPKEPNNHTFTYRGNRDKMQAGVDVQRVCYQHLDKVKIGFGQHSTPMRNGNPCFHKKAGDKQESSLADQSTGDADQTKPKNEIVGSPHRIPERHNQSSRYREIRDNQEPSVDHKAIDPHQNTKKGMGYSQLMSPKENHPVKISGTAAQGASDPEEIRTKSGKECSPHRSPKMHDHSLRHREVRDKPQPGINTQRAYDQHLNSPKKRMTSENLLTPKGTNHPCWHRVTGDKQQSSLSDQRACDPEQMRRSGMSSYPQRSPKVYHLSCSSEKIGEKLLPLVNDQRTHDKHPNSVKTRGCDNLPTPKGSNHPQGYRVIEDKQQLGLAYRRTCDPGQIKKSGMGKGPCKDTEECNLLYRYKIIGNKQQPGIVHRACDRHQSSKEGMGQGQPMNPKVCHSAKHRRTGGQDQSGVAAQGASNPR", "length": 1373 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDD6-1", "protein_name": "Synaptonemal complex central element protein 3", "gene_name": "Syce3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSDPGERSYDNMLKMLSDLNKDLERLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ", "length": 88 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDJ1-1", "protein_name": "Olfactory receptor", "gene_name": "Or13c3f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDDMDKNNQTFVSEFLLLGLSGYPKTEILYFVIVLVMYLVILTGNGVLIIASIFDSHLHTPMYFFLGNLSFLDICYTTSSVPSTLVSLISKKRNISFSGCTVQMFVGFAMGSTECLLLGMMAFDRYVAICNPLRYSVIMSKEVYVSMASASWFSGGINSVVQTSLAMRLPFCGNNVINHFTCEVLAVLKLACADISLNIVTMVISNMAFLVLPLLLIFFSYVFILYTILRMNSASGRRKAFSTCSAHLTVVVIFYGTIFSMYAKPKSQDLTGKDKFQTSDKIISLFYGVVTPMLNPIIYSLRNKDVKAAVKYILKQKYIP", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDT4-1", "protein_name": "Transmembrane protein 92-like", "gene_name": "LOC100364194", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQEAWVLDALTVIFGLLFSLQGVSSNKTIYKCEDIHCPKGFRCCDNECCLERKIWNTDNEPFRILFIILLVMLPLLCICGLVRRFCPKCRELQHEVRTADHQSPPDPPSIAPLESIWVTSLDPPPPYSQVVQKSTPTEPPPPYSLRPEDSTCPMRETSHETL", "length": 162 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZFJ9-1", "protein_name": "Family with sequence similarity 24 member B", "gene_name": "Fam24b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSSFDLRTIIMIVIGSGILAAMFLLTGVVLCLYSKIARALNPSGTGKELDDQLCSDPCKTTQDQIIRVNSLNADTCRPFHGSTIGLENCQPLQCFSACGTYEGANSLTPCLCNTKEGL", "length": 119 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZFW5-1", "protein_name": "Transmembrane protein 107", "gene_name": "Tmem107", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRISGLVPSRFLTLLAHLVIVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFIFERWECTTYWYIFAFCSAFPAVTETALFIAVFGLKKKPF", "length": 140 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZG05-1", "protein_name": "40S ribosomal protein S12", "gene_name": "LOC120100003", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEEGIAAGGVMDINTALQEVPKTALIHDGLARGICEAAKALDKRQGHLCVLASNYDEPMYVKLVAALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFEYKK", "length": 132 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZGM7-1", "protein_name": "Peptidase inhibitor 16", "gene_name": "Pi16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNCRVSWMPQHSSAAVSGICPPQEGPWSSYSLWPEPPLLREKEAVAKDSRGVDSTLVQTQGTQPSWRHCVSWAGPPDTAPAAPPQPGWCLCGKDFKSSRQTPDRERQRGLATMHSSCSPWVMLPQLPLLLLLLLLLLTATGPATALTEDEKQTMVELHNHYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNLSTATCDPGQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGYSCVNSLCEPERKPEKAQDSPPRVTEVPGSRETGIPSLATSESLHFSSVTKVSDSLATEPSPAVETKAPPSLATEGPSSMATEAQSFLTEVPSVSATHIQPSLDEGPVNFLTSTHIPVPKSTDKEASSKSRAASVSPEKSLYPKMSPTETGESPPQIQEEAEPKAELPEREDELPEAEVELPEAEAELPEAKAELPVSSEALVPVLPAQERGGPKASLEHSSYPVPTYLPNFPSASGNATGGRTLALQSSRTGAEDPEKASWDSKNSAPVWGPFPGLLLPLLLLAGIF", "length": 596 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZGX2-1", "protein_name": "C-type lectin domain family 2, member M", "gene_name": "Clec2m", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQTESSLRLSQSSHHRLTFDLKKVVTLWILVIGVIAVLLWGFFSFPKKFTVTRQTKNEVCSDGVKICLHGWNKLNRNCFTHFSHANSWFTAKETCKFHDATLAVFNDQTELDIVMKQMEDIQTFWIGLYKKDFRGPWVWTNGSKYNNWYEVQDYGHCAFLHKSGIDSTNCNDLKEYICTQEGHCP", "length": 185 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZIZ8-1", "protein_name": "Ferritin", "gene_name": "RGD1560203", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEASSQVRQNYDRCCEEAVNTHIRLLLQASYSYLSMAFYFDRDDVALENFKRFFLSKSHDCKASVEMFVFMQNKRGGHVFLPSIAKPDRKSWQGGFRAMECAFRMEMTINQSLLNLHELAKGKGDAHLCNFLGQHCLDQQVHVLKKIGGYLTNLRQMGAPEQALAEYLFDKLSLS", "length": 176 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZKK4-1", "protein_name": "Zinc finger protein 869", "gene_name": "Zfp869", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTPIVGLSSPDQGLVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVGYEWEDEAIEDHCEEPEVNLRDIVSHSEYTHEYEHKEYEEKPPDANFLTSVEGCVETKTSSGPSVCEVCLKTFGLYHLTYNGHHNYDYKELRGSQTEENDCEGNSCDKTSGSLQKEDKIHTGKKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLSALQLHERIHTEERPCECKQCGKTFRYSRALKLHERIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASYHRHKITHGGETLYECKECGKSFIYPSLLQVHERTHTGEKPFECKLCGKAFRCQSSLRLHERTHTGEKPYECKHCGKAFSSYNYLRFHERSHTGEKPYECKECGKTFTHRSYLRSHERRHTGEKPYQCIQCGRSFSRHSSFKRHQSVHGESPYEQYLIPLSPFSSKE", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZKM3-1", "protein_name": "Protein GPR15LG", "gene_name": "Gpr15lg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLLTLSGLFFMLFLCLCVLSSEGRKRPAKFPKLRPCCHLSPRSKPITWKGNHTRPCRPCRKLESNSWVVPGALPQI", "length": 77 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZL22-1", "protein_name": "Olfactory receptor", "gene_name": "Or1x2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKWGENETGVIEFLLLGITNDPQQQRILFWAFLCMYLVTVAGNTLIFLAISSDPHLHTPMYFFLANLSFDDVCFTTNIIPRLLAGHVSGTETISYAYCLTQMYFLISFGNVDTFLLAAMALDRFVAICYPLQYHTIITPRLCVGLASVVWISSGLIALVHTLLMSRLTFCSSIPEISHFYCDAYLLMKLACSDTRINQLVFLGAVVFFVAPCILIVFSYVRIAMAVFQIPSAKGRHKAFSTCSSHLTVVILFYGTVLGIYIRPPDSFSTQDTVATIMFTVVTPMLNPFIYSLRNKDMKETVTRLLHRGSKSS", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZLG9-1", "protein_name": "N-terminal Ras-GEF domain-containing protein", "gene_name": "AABR07047293.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSCCVWTTEGSGLKKDKNEGQGGTWKFMLLSCLQCLWPFAQKEIDLTRDNQAQDHEDQGEHEYAPQVVTEPCRESRISADMVENLVNRLVSSLQGGDPFFIPAFLYGYRQFTTTQHVLDRLLKRFAYFYLGCEEDEQIKSSLCCFLDTWIDQYPEEFSQTILKKLKTYLTVNMPSSDLNLRVHMLLKELRQESNESEGKDDDSVSLPVTLLYKTASAADLSSSVEVGSHTSGDLDIEVWFPSQKVQPEPAYPHETETPQSTIKVISWD", "length": 269 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZLZ3-1", "protein_name": "Similar to human chromosome X open reading frame 66", "gene_name": "Cxhxorf66", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKERFTEADTGAKLDDFRKRLLGFIVGIMIIAFTFTCFCLLHYNCMVEEVQSPGGLNKENMAAISSWVSKVSACQPDMITEDILEAQPLLFNSDQLSGPSCQEKHLISNNIVKSIQPSSLEKSCIPSNVQKTTKYINIEKSSTSCSPKPSNRLLESKRSIKSSDPKRLHKSSHMERTCKKHNIKKSQKITHGYKLGNVNSSCSDKQVTPWLAVLKTSTKQITQSSSSIPCKQSTFTKPCRIRKPNLPYGHYEVKRPANRGKTLFPKPTAAKTCRHYKERCLVCNTSGFLLNDLSGAEKNHAGNICGSMKMKPCLHTFYDTEYKYNYYQKSVSNDTMKMYDSEDSNAEIVIICDTSQDDITNKGTFRY", "length": 367 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZMT2-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "gene_name": "Ndufa3-ps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGRSSDFFKNAQAKEPVLVVSFSVWGLAVILPMISPYIKYAGVISKATPYNCPVPVRDNGNVPGVPSQPQERLSPSLERLKNL", "length": 84 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNA3-1", "protein_name": "60S ribosomal protein L7a", "gene_name": "AABR07049918.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQETKNVVNPLFEKRSKNFGIGQDIQPKRDLTRFVKWPHYIRLQWQRAILYKQVKVPPAINQFLQALVRQTVTQLLKLAHKYRPETKQEKKQRLLAHAEKKAAGKGDVPTERPPVLRAGVNTVTTLVENKKAQLVVTAHDVDPIELVVFLPALCRKMGVPYCIIRGKARLGRLVHRKTCTTVAFTQVNSKDKGALAKLVEAIRTNYDDRYDEIRCHWGGNVLGPKSVARIAKLEKVKAKEFATKLG", "length": 266 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNR1-1", "protein_name": "Elongin-B", "gene_name": "Elobl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVFLMIRRKKTTIFIEAQELTTVLELKRIVQGILKRPPEEQLLFKDDQLLDESKTLRDCGFTSRVAKAQDPATVGLVFREDASEGLQIHPYSTPLLPSVMKTGTDSLE", "length": 109 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNU6-1", "protein_name": "Olfactory receptor", "gene_name": "Or5p66b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSWLENGNHTTVAEFLLLGLTDDPVLRVILFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASVDIGYSSSVTPNMLVNFLVERNIISYLGCGIQLSLVAFFGAAECFLLAAMAYDRFMAICNPLLYSTKMSTQVCILLVVASYIGGFLNASFAMVSFCSFLFCGPNIINHFFCDFAPLIELSCSDVSVYVIATSFSAGSVTMITALVIAISYSYILITILKMHSTEGRQKAFSTCTSHLTAVTLFYGTVTFIYVMPKSSFSIDQNKIVSVFYLLVIPMLNPLIYSLRNNEIKSALKKQIWRKTVS", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZPU6-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC134485591", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKGKRRSTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAEGIIVNKQVKGKILTKRINVRIEHIKHSKSRDSFLKRVKENDQKEKEAKEKGTWVPLKRQPAPPREAHFVRTNGKEPERLEPSPYGFMA", "length": 160 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQ96-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC102550668", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKVKRRGTRYVFSRPFRKHGVVPLVTYMRLYKKGDIVDIKGMGAAQKGMTHKCYHGKTVRVYNVTQHAVGIIVNKQVKGKILAKRINVWIEHIKHSKSRDSFLKQVKENDQKKEEAKEKGTWVQLSLQPAPPREAHFVRTNGKEPELLEPVP", "length": 155 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQD9-1", "protein_name": "Developmental pluripotency-associated protein 3-like", "gene_name": "LOC120096627", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDKSSEKVDPVVNPETQMNDGSQREDEEDSPDDSEILQPETLVKVMKKLTLNPSAKPPKYHRHQRVRLRIKSQPVGNRSERIMREVQSAFPKTRVRTLLSVLKDPIARMRRFVRIEQRQRQLEGNERRDEPFRCLCTFCHYQRWDPSENAKIGQNQKN", "length": 158 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQT0-1", "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "AABR07071101.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILCIKPSSTTKYCLNQCYLISCINKPNLLDGVNGIPLDIVAINDPFIDLNYVVYMFQYDSTHGKFNGTVKAENGKLVINGKPTTIFQERDLANIKWGDADAKYVMESTGIFTTMEKAGAHLKGGTKMVIISAPLADAPILKYDNSLKIVSNASYTTNCLAPLTKVIHDNFGIVEGLMTTVHTITATQKIVDGPSGKLWRGGHGAAQNINPETTGVAKAVGKVIPELNGKLTGIAFHVLTPNVSVVDLTCHLKKPAKYDDIKKVVKQASKGPLKGILGYTEDQVVSCDFNSNSHSSTFDARTGIALNDNFVKLISWCDNEYGYSNRVVDLMAYMASKE", "length": 338 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZTK7-1", "protein_name": "Uncharacterized protein", "gene_name": "AABR07012426.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGDLEAKISGYTHISVQRFCYKWTISNFSFCMDGIRENITSPVFSLEGNEEVQWCLRIFPNGVDEESKDYLSVSLGLHSCPKSPVLAKVQFWIINAQGEKHQIKEIPNILSFSPKHQWGLRKFILREFLLSRRHGLLPEDQLILCCKVSVVGPSFSTPGHNMTPANKDPRQMLADDVGELWENSLFTDCSLVVAGQEFRAHKAILAARSPVFRAMFEHEMLESLTNRIEIHDIHLQVFKEMMAFIYTGKAPHLHSHSMATELLAAADMYDLQDLKVMCEDSLCRNLSVKTAVPTLMADLHSTELLKTRVMDFIILHASEVSETLEWKSMVESHPHLVEEAFGSLASMHYFFLEPSLKR", "length": 359 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZV50-1", "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "Rps9l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVARSWVCHKTYVTPRRPFEKSRLDQELKLIGEYGLRNKHEVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIVVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLRLAKSIHHAHVLIRQRHIRVRKQVVNIPSFIVCLDSHKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEKKEK", "length": 195 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZWL0-1", "protein_name": "Ribosomal protein L32 like 1", "gene_name": "Rpl32l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALQPLVKLKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILKPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNLNARLRSAENE", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4A176-1", "protein_name": "Golgi associated RAB2 interactor 5A", "gene_name": "Garin5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRLRTSARSPAPAVRMAISPSGPLGFTSPVTQPRREASPGVPTTQGRGVAMKGGRDLKPASGRADRPLAQAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDVSRQQLKVKFRTGRAFYLQLRAPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTVPEESEDEDEVEEGQLQPPEVRAGPRAQGCWARKDGKGPVSCHRGQTRPAGLRTLGALIQPRSFQITKGPEIKPAQLRAREMDF", "length": 303 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4A9N2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4a77d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQNNSVSEFILLGLTEDPAGQKTLFVVFLLIYIGTMVGNLLIVWTVIASPSLDSPMYFFLAYLSLIDALYSSTILPKLLIDLLCDKKTISLTACLVQLFVEHLFGGVEIFLLVFMAYDRYVAICKPLYYLTIMNQRVCVCLVVVSWIGAFAHALVQVFSVYKLPFCGPNIIDHFACDMYPLLGLACTDTYFLGLTVVGNNGAISVVVFMLLLLSYGIILNSLKTHSQEGRRKALSTCSSHIMVIVLFFVPCIFMYVRPVSNFPLDKFITVFYTVFTPMLNPLIYTLRNLEIKKSMEKLCRKIFTSDRIRISSCYS", "length": 316 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AAM5-1", "protein_name": "Preferentially expressed antigen in melanoma-like", "gene_name": "Pramel", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVKTPNKLLELAIHSLLNEESAAIQALEEIPRELFVPLFIAAFEGGHKNVLSAMVKVWPYYCLHIGSLSIQEPQHELLKAMIENLPVYPAPSSSSRGPKLRILDLRQDTDCRITCPEVSTKTPSCFYSCAYSDRSITKIERQLCCVNAECKTLLPRPVELLVDLSLDGSLMEKEFLVLLMYKIEESLGSLHVCCRDLQIDKLCKCKCTLKFLDLKCIDQLSVDRGSLSDITSILCRMIHLESLSLSNVTFRSLSGKVFKIFLSHLQRMEHLKELSLSSFCLKNHLDRVLRILPPGLDFLYLPFCDLSYRDFKFMSQSPQVTHLKLLNLSNNPMYWGDFEPFHTVLINLSGTLQHLEINHCLISDSAMSALIPALIRCTRLRVLGFASNPISMPMLVNIMHNLTPMKELKYVIYPIPVHCYERWHFQGSLDRQKLAIVQLQLKAMLELAHREDMNWITYCE", "length": 461 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AAN9-1", "protein_name": "Similar to human chromosome 6 open reading frame 52", "gene_name": "C17h6orf52", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVETQSPGKECAVLPLWVLTVTSCPLPSAIREQLRVHHSLRCHRDNHYELLHSFYWLSCYSRGSTLSGNGLGPLCVTENPELLAGPWAIPEETTDPAENQEEDFLRDPNLHLNIEESDKEFMAVREELYDSLMNRRWHCLDTVLSNVPDELPQCEVF", "length": 157 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4ABB6-1", "protein_name": "Olfactory receptor", "gene_name": "Or13a27c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VNCIWHSKMVSPNQTVVTEFVLQGFSEHPSLRLFLTGCFMSLYTIALMGNIVIIALVTSSTGLHSPMYFFLCNLATMDIICTSSVLPKALVGLLSEENTISFKGCMTQLFFLVWSGSSELLLLTVMAYDRYVAICAPLHYSSRMSPQLCGALAMGVWSICAANASMHTGLMARLSFCGPKVITHFFCEIPPLLLLSCSPTYVNSIMTLIADAIYGGINFVLTLLSYGCIIASILRMRSAEGKRKAFSTCSSHLIVVAMYYSSVFFAYISPGSSYNPERSKFTSVLYSVLSPTLNPLIYTLRNKDVKLALGRILASFSH", "length": 318 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4ADX2-1", "protein_name": "Olfactory receptor family 4 subfamily A member 80", "gene_name": "Or4a80", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQSKIVTEFVLLGFTQDPAGQKALFVMFSLMYIATMVGNLLIVGTVIVSPSLGSPMYFFLASLSLMDAVYSTAISPKLIVDLLREKKTISFRACISQLFIEHLFGGVDIVILVAMAYDCYVAICKPLHYLIIMNRRVCILFLVMAWAGGFAHALFQVLAVYNLPFCGPNIIDHFGCDIYPLLLLACTDTYLIGLTIIANGGAMCIVIFILLLLSYAIILRSLQNHSQEGRHKALSTCSSHITVFFLFFVPCILMYVRPVSSFPIDKSITVIYTVVTPVLNPLIYTLRNSEMKNSMEKLLQKILSPNRLRLLCCLYY", "length": 317 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AEJ6-1", "protein_name": "Peroxisomal biogenesis factor 11 gamma", "gene_name": "Pex11g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLNGLASALESYRGRDRLVRGSVGPWRDRSDLEFGQDSEMRKTGQRGGPKGTDIGRLVSYMRTSYLSLPNCWPYKCVLALQIRTLGYGCQLIGGVLVEQCPSRSEVGRRLLVVSAQLSHCRTVLRLFDDLAMFVYTKQYGLGAEEEDVFIRWLSVLSNMADQLYYPCEHVAWAADAKVLQVDSARWWTLSTAFWSLSLLLGAVKSLWTMLKLRQKLRSPTGHFASQLPRSKWRAVEARIWSEALTLLSNLADLANAVHWLPPGVLWAGCFPPWLVGLMGTISSILSVYQAARAGKQAEVDSP", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D6R901-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 21", "gene_name": "USP17L21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "E0CXP6-1", "protein_name": "UMAP1-MVP12 associated (UMA) domain containing 1", "gene_name": "Umad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFHFFRKPAESKKPSGPEPEADGFVLLGATANEVRCKTSEAEGSQALETGKEDTSSVTVSGPETENQTGQTLQNNSLTAELLSDVPFTLAPHVLAAQGTISDLPDHVLSYDVGDNLSRFWYDFTLENSVLCDL", "length": 133 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E0CZF1-1", "protein_name": "PRAME like 34", "gene_name": "Pramel34", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGQTPPTHTLLTHEALIMSSLEELPTVVFPALFKEAFAGRHTNLLKAMVAAWPFPCLPVGPLMKKPNLETLQALLDGIDMRLTREFHPRRAKLQVLDMRNMYHAFWNIRADANDSDCKSKTLDEKQLVKVLPRYARRQRLKVIVNLSISSHFNKSKAYFLNWAKQRIGSLYFCCIKMRIWDPPDQVIRDIFNVFDPEHITELELNTDWTLLQLAHFASYFGHMKNLQKVFLAPLHKNTSPIINITNATEAKCVHKIISQFSQFNCLQHIFMKHVHFLRDYMNQVLGCLMTPLETLSITQCLISQRDFDLFSCSQNLFKLKHLEIRGMILYALDLMPLRVLLEKVADTLEILDFQWCRMKDSQINALLPALSQCTQLNQINFYNNDFSMCTLKALFQHTANWSKMNVEQYPAPLQCYSELGHVSVERFVQLCQELMYTLRAIRQPKSISFATDNCQKCGKPCVYDQGPILCSCFQ", "length": 475 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E1B8K9-1", "protein_name": "40S ribosomal protein S6", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKLNISFPATGCQKVIEVDDERKLRTFYEKRMATEVAADTLGEEWKGHVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKCKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPHRLGPKRASRIRKLFNLSKEDDVRQYVVRNSLNKDGKKPRTKAPKIQRLMTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK", "length": 249 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E1BBD9-1", "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "LOC112445820", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MPFLPLRLAVVCSSNQNRSMEAHNILSKRGFSILSFGTGTNMKLPGPARDRPNVYDFRAMYDDVYKDLLRKDKERYMQNGVLRMLERNMEKEMPRPERFQECKDLFDLILTCEERVYDQVVEDMNSGEQETCQPVHVINVNILDTNKEATLGAFLICDLCQCVQLMGDMEDRIGELLQAFEEKSGRSFLHTVCFY", "length": 195 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E1BLY1-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIIRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLSSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E7F638-1", "protein_name": "Moesin b", "gene_name": "msnb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSINVRVTTMDAELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYQDSKGFSTWLKLNKRVTAQDVRKENPLLIKFRAKFYPEDVAEELIQEATQRLFFLQVKEAILNDDIYCPPETAVLLASYAVQMKHSDYNSEHHIPGYLCRDKLLPQRVLEQHKLTKEQWEQRIQVWHEQHKSMSREDAMIEYLKISQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYERSDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKSPDFVFYAPRLRINKRILALCMGNHDLYMRRRKPDTIEVQQMKAQAREEKNKRQQERALLENEKKRRENAEKETEKIARETMELMERLRQIEEQTKKAQEELEEQTKRALELERERKFAQEEAEKLEKDRRIAEDVKTALLQQSENQTKNKDNLATELAELTSKINLLEDAKKKKEDEARKWQRRAIMVEVDLEKTKEELKSKLIGVHIQATSQTENDHDENDESSAEASAELTSTGSFRDRSEEQRITETEKNEPLQKRLQALSSELADARDDSKKTANDLIHAENVRLGRDKYKTLRQIRQGNTKQRIDEFESM", "length": 577 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FA22-1", "protein_name": "Protein tyrosine phosphatase type IVA 3", "gene_name": "ptp4a3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAWLNGLYPVEVCYNSMRFVITHNPTNQTLDTFIEDLKRYDAKTVVRVCESTYDKTPLEKHGITVMDWPFDDGAPPPTKIVDDWISLLKKSFSEDPGCCVAVHCVAGLGRAPVLVAVALIEGGMKYEEAIHLIRLKRHGAFNSKQLTYLEKYRSKKRLRFKDPFKHRSKCWLM", "length": 173 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FE27-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase", "gene_name": "b4galnt4b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRMRFPLKKIRKQFKLLLLLVLLMFAIGFTYLHINQGKAIKLHFNYGKDMERQAEGIGSSPKKHLSSSINPFEHGDAADSQEDGWGGEELNESAQESRANAEMHTLLAQKFLGLPWKPEYKGQANLHVFEDWCGSSVSQLRKNLHFPLYPHTRTTVKKIAVAPKWKNYGLRVFGFIHPYKDGDFQFAIASDDNSELWLSSDESPLNARLLVYVGQHGSEWTAPGEFSKFRSQTSKPVRLMSSRRYYFEVLHKQDDRGSDHVEVGWRPFLPGQKFDVIDSAYISLYTDESSLKMNSVHHIPQTLASHSLALQIYHRTETHTADMLKPDPRDTFYKIPMIDQSRLENVLPSCVYSPTYVVKDFPIARYQGLQFVYLSYVYPNDFTRLTHMEKTNKCFYRESPVYLEKFGFYKYMKMDEEEDDQPVFFPKPDDFLEEEEGVDPEEAINSSNRPVKRSGPSYQTSRITAATASSKPDRLDGGSKSSVFQQEKQYVQFKEQERSKKRTKGERFYRHSQVVDDEMTEIRQVKGSTGVLESQSGSLNEQTGPSEENGDSQTLSLVQRGRSLAWVLPDPALQSESKLIETASPTVKERSPFKLPHLYVLANRILGNAGKPVVEKESNSNKIYITRPRPPVSRPKPPVEVFPGVFLYQSRKSKRLVDLSSKWRSLKTQAAASAPWANFPLMDHKTSTQSALLKQSHLSSPTEPGPHNKGDPTASISDPDSVPPSSSEKRDHPGLNSSSQPPEEEPTKISEMAEGLDVAPQSRGLEEGEMSEYSYEEAEVRPHLAEEAINWQRTFSVNPVDFELLRSDWNDLRCNVSGNLQLAENEVIDVISQFMERLNERNRGIYTLARIVNVEKRRDSARGNRYLVELLLMEGGKRLVRLSEYIYLLLHRSRFEEGIESREGTVPSSHRTPSKIPLPSGSSAQTHTTTPWSTSWAKPLLCQPIMLQWRHDVMVHFVVPVKNQARWVQQFISDMELLHRETKDENFSVIIVDFQSDDMDVEQALKESTVPRYEYLKREGNFERSSGLQMGVDTIEDSHSIVFLCDLHIHFPHNILESIRKHCVEGRLAFAPIVMRLDCGSSPLEPDGFWEVNGFGLFGIYKSDFDKIGGMNTEEFKDHWGGEDWELLDRVLQNGLEVERLRLRNFYHYFHSKRGMWNVPVKRASQG", "length": 1167 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FFR8-1", "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "gene_name": "uqcc5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLRKSQNLKYMLSLVPGKKRFGVYRFLPVFFCIGGVMEWIMINVRIGRETFYDVYRRKQSERAYQQKTEEGLIMLTDSQAK", "length": 81 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9PUW9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r143", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFFHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PUZ0-1", "protein_name": "Apolipoprotein L 11b", "gene_name": "Apol11b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWNEISEDIRKVECRTFEKVIDNATEDLITDLRSLITEDGAWNGFVEAVELSSEEGEALRDALKERLAQDPTDENDRPQREQQKERFLREFPQLKKKLEDHIRKLRDLADKFDQVHKDCTISNVVSTSASAASGVLALLGLVLSTVTAGASLALSASSVALGATSSVSSFTTTVVEDSMTLSYESEARNLIGASMNVLEEILSIMPKITCKFYNTVADLVKAFKTLKGQIQTIRRARSISRRGAQARNLTSTGRSSGQGVSQMTRGARIRAGVFTSVFLGWDVYDLVTKQRICMMGEKQSQVEHCGTWLASWRRTFRNLSRSTMLCSQTCLSDALP", "length": 337 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PV04-1", "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "Eif4a3l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATTTRMATSGSARKRLLKEDGMTKVEFETSEEVDATPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIMKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACVGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLTTRAIKMLVLDEADEMLNRGFKEQIYDVYRYLPPATQVVLVSATLPHEILEMTNKFMTHPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCITKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNLADLI", "length": 411 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVP9-1", "protein_name": "Predicted gene 4884", "gene_name": "Gm4884", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSENLQSSPFFGTESTLHPSLPLLSNSKQPAGTVCNFSRVSTPDVSSAWLLPSASSTSLQPLMVVQMETSLGLPPSGQTYCQLQSPELCNTCVQVSQIRPPAVNGDKALTAPIHSPSQFLALPPAPSLEQPENKTMPEIKEGTKENQDTPVLTLEHPDLQQPLHCTDTESLRQKPDSDNAHLGCICMGPKELVGLENEIGSSFDFKDITRFGADIQLPQLLNTLTDIDQDQSCENWRVTSGLFDQVRENKHKSFELLEGAPQAKFQHWDLVEGEGAVGVAGASDRAIDNMAKHPEGKAPKGPPSKNRRARKQEQERPSGPENKSKKTQELKQSRNRVKAEKEPSIPKTKRKRNPPELSQNSFKKPRTNLAMHMLESVQVFHPLGKKSEKKTGISSFRGLRTFTSNKDSGPGSVTTTVLNMPCESQGPPKSPGKVQSAESSVGKDCLSPSQYELPPAGKVKLVPLPFPTLDKPQSRPASRKPLSLALRRPTAVYPVQHHSHSVQPTTLRPAQPPPASSSLIASAKPAPPISSSATGPNVTNPNQSSAVPQLATSRPVPYRASSHTSFQRELVSAARNKVPSPPRPVPYRASSNTSFQRELVSAARNKVPSPPKPQTQYLLHDFSRQPIPWKKVDILGPVVSQPITKEQRPEREAMKRRSQQERENAVKNPSTGKLQIFLQRERDMEISQYYGYAM", "length": 694 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVW0-1", "protein_name": "Major urinary protein 8", "gene_name": "Mup8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCVGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIRVLENSLVLKVHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNAMDLVPEHVLVLTRQIAASRPENEEWPEPPVLSGDFSPGLHHHPFLSIQHPQYKFCDLHSILSH", "length": 235 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVZ7-1", "protein_name": "Olfactory receptor", "gene_name": "Or8b3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKYFCLPRFSIISMLTGNGSFVTEFVLAGLTDRPELQLPLFYLFLIIYTVTVVGNLGLIILIGLNPHLYTPMYYFLFNLSFIDLCYSSVSSPKMLMNFVFEKNSISYEGCMTQLFFFLFFVISECYMLTSMAYDRYVAICNPLLYKVTMSPQVCSMLSFASYGMAFAGASAHTGCMLRLIFCNANVINFYLCDILPLLQLSCTSTYVNEVVVLIVVGINITVPSFTILISYVFILANILNIKSTQGRSKAFSTCSSHIMAISLFFGSGAFMYLNHSGSMNQGKISSVFYTNVVPMFNPLIYSLRNKDVKIALKKVMMRVHSRFIS", "length": 325 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PW18-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r257", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPLSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PW59-1", "protein_name": "Olfactory receptor", "gene_name": "Or8b50", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALANGSFVTEFILLGLTDQPDLQMPLFLIFLIIYLITAFGNLTLIILIVLNSHLHTPMYFFLFNLSFIDLCYSSLITPKMLMNFVLEKNIISYMGCMTQFYFFGFFAISECYVLTAMAYDRYVAICNPLLYSVAMSPKMCSYFILGSYFMGFSGAMIHTGCVMRLTFCDGNTINHYFCDLLPLLQLSCTSTYVNEIELFIVTGKDIIVPTVIIFASYGFILSNILKIRSTSGRSKAFSTCSSHIIAVSMFFGSSAFMYLKPSSAVSMNEAKFSSIFYSIVVPMMNPLIYSLRNKDVKVGLKKTLSRMFSHNLISL", "length": 316 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PXC3-1", "protein_name": "Cytochrome P450, family 2, subfamily c, polypeptide 69", "gene_name": "Cyp2c69", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPFVVLVLCLSFMLLLSLWRQRSARRNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKGKGIGFSHGNVWKATRVFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRHNKFFKNHTWIKSYLLEKIKEHEESLDVTNPRDFIDYFLIQRRQDKGIEHMEYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRKHMPYTNAMVHEVQRYVDLGPTSLVHEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDTTPKYSGFSKIPPKFQMCFIPVE", "length": 491 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PXM9-1", "protein_name": "F-box and WD-40 domain protein 24", "gene_name": "Fbxw24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLSSFPMMEIFSYLDAYSLLQVAQVNKNWNALASNDFLWRKLCQERWLFCDMVTLQLLGKETWKQFFVYRTWQEHVKSRAIPEDFTYKEIPLECGVRGYAGYISGCALTRNGQGKSVVCMVSSKNKISTWDISESVITWVSPVQPASIKLLTTLPDMHIAVTVDIQSTIKLWDCHNREALATNNLESPCKSLKAVISKDGPIVLAGDILGNLYIFRIPDLHLISTVNVFPCGFDKIDCSPQKKWVLLSQNHPCIYPKVFYMSSLLRTSEFSDPVSTVLEFSLCKRAFWTPRREDRITLMSRRGRPIVTRFETFDMKLEENGNKTIVKGDLVASFSLQDYNENPKWMGVSDKSVIVCSTGSSLLLFSMKGLHLQTFQYSPEMIVRLWVDPVHVIITCNDGSIDVYMWEERSLLLKMCYRLQNGRHLPPFGFIKNLLCDDVSIVQLMIDRQGPCFLMAYTLNICS", "length": 466 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q069-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r157", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCHFEVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNFANYSCYSCWFFSVLSNIHIPIKVTGPQIIDNNTYDKSNLFCSTSGFIVGIVFLQISHDATFMSIMVWTSVSMVLLLLTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPNDPCSVLFKC", "length": 297 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q0V3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r68", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVAIIKENQTQSKMDFWNMGIKILFLSQTTTGILGNFSLIIYYVVNYIVHTLKPTDLILMHLMTSNALMVLSTGVLHTMAAFGLAHLLNDLGCRLILYIQRVGRSTSIGTICLLSIFQAITISHRVSCYKGQKIKSSKYIGYSISLLWVLHMFLNFILFVDIFIKRNRNNMTSDRDFKYYSIVERNEFSDSLYVALVVCPEIFSSVLITCSSGSMIGILYRHKQRVQHIRSFHVSSRNSPEWRATQNILVLVSTFLAFYTLSSVLQGCIALLNNPNWWLVNITRLTSLCFPTFAPCVLMSHYSFMPRFSLVWTWNKTS", "length": 319 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q1C7-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4A2", "gene_name": "Speer4a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWMGETREGRKDADLPSKSNEGRRRWTWRMWMAHRQKTSPVPVTSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHNLEMENMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIHQRLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 252 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q1N7-1", "protein_name": "Predicted gene 8126", "gene_name": "Gm8126", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGNQGETRPRQKESAIPSCKNRRMKSFWGRHMSAGKTSSQNCNITNHMKNRNKLDDMKFYIRKINAERLELFRILDIDMNTDLNYRMNIEFTIIKSQHEKTMLDMEKITQSINDTIEKYKEFIEDKDSYSFMHTYLLKECNQLKEKVRMLLNENRKLLVEQADQEASYGEENRFCHESSKNIHPKY", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q328-1", "protein_name": "RIKEN cDNA 5430401F13 gene", "gene_name": "5430401F13Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSRILLVLLSIALLALTSAQRVNEDDGSALQEEDALEIGDSNQQHDDIHERLNEIKNHFQDQISQHGKEAIKSKKGKNGPRSRRSSDDDNLEVQDHQSGNEQAGGGQGGRGRSELKGQNGKGSQKGKKGKGGQQEQKGKGGQQKQKGKGGQKTKRGKGGQRSQQDNVQEVYQE", "length": 175 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q346-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r160", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILIHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVPVNRGKGKLILRASIPNLWNYSCYNCWFYSVLSNIHIPIKVTGPQITDNNTDSKSKLFCSTSGFIVGMVFLQFAYDATFMIIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHAFSIHSHLFIRLVSVVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q366-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4f2", "gene_name": "Speer4f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTMCVRLRRLFQRANVDGRETREGSMDAGLPCERNEGRRRWTWRMWMAHRQTSSPVPVTSNQFEKEEEELMEEIQLISQEKNGLRDYLNLTLGSKITRLNQSYEELKLKQKELMTLQHDLEMATMEAREENEELKKEINFYSNLHSRALMENNLIKKKLMTLQQESKEVQAEWASIQQHLDVNLSGKDEQENNSILDTQEHQVSETARELGLATDQEDSILQDELPPQEAPAEELSPQEAPAEELPPQEAPAEQLPPQEGPAEELPPQESPAEHHLQHPQSFSDESSYITYPEWE", "length": 295 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q3G0-1", "protein_name": "Zinc finger and SCAN domain containing 4B", "gene_name": "Zscan4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPIPDNAQMPVDTTQDRLLATGQENSENECNTSCNATEVNVGESCSGNEKDSLLITQKEQNHEHEEGNVVCQFPRGARRASQDTSSHHVDFPSALTPADVPMEEQPMDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKTDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQPISDPVLGKNHEANLPCESHQKRFHRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCITCQKIFKRVSDLRTHEIIHMSEKPFKCSTCEKSFSHKTNLKYHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 505 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q4E0-1", "protein_name": "RIKEN cDNA 5031410I06 gene", "gene_name": "5031410I06Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q501-1", "protein_name": "Predicted gene 2237", "gene_name": "Gm2237", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENVDEGETRPTEKEEGILSHEKGRRKWFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNSSPAESRTWH", "length": 211 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q5G7-1", "protein_name": "Oogenesin-1", "gene_name": "Oog1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGYIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSAGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFSLGDSEKLDEETIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPYCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELDSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPLECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVELL", "length": 496 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q6D7-1", "protein_name": "RIKEN cDNA 1700024B05 gene", "gene_name": "1700024B05Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESHDNPVSAGRTSSQNCNITNHMKNMNKLDDMKFYIRKINAELEELFRILDIDMNTDLNYRMNTEFTIIKSQHEKTMLDMEKMKQSISDSIDKYKEFIEDNDSYSIRHTHLLKECNQLKEKVRMLLNENRKLLVEQADQEASFGEEKSSVMRPARTYIPSAKQQQL", "length": 167 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q7M8-1", "protein_name": "Predicted gene 5796", "gene_name": "Gm5796", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPKKKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQSGHKCPVGKKRGSLRRPARTSVSQVPRNSSVI", "length": 205 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8A4-1", "protein_name": "F-box and WD-40 domain protein 28", "gene_name": "Fbxw28", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLPSVPMMEILSYLDAYSLLQAAQVNKNWNELASSDVLWRKLCQKRWLYCYMFTLPLHGLETWKQFFFDKTWQEHAKTRAKPEDFTYKEFPVEFEFRAHPWYISRHGLTRNGQEKSAVCMTSMNRISTWDIHEGAMTWESPKQPSYIVWMTTLPEMQIAVTIDMQSTIKLWDCHNKEVLASKTGLFFGCKLLQSEFTKDGPIVLVGDACGNLYIFRIPDLHLISKVNVFPYSIDELYFSPQKKWVFLIGHRLNDLTKVFYMSSLLRPSEFSAPVSTVLKVPVIRKVFWTPRREDRITLMSLILPKNITKFDTFDMKLEGIGNKVTIQGYLTASFSLAEDEGRPDYFGVSDKDVIVCSTRFSLLLFDINGLRLQTFHYCPEEIWRLWVDPVHVIVTCDAGSLDIYAWEKRSLLLRKCYRLRNRNYQQMSGYIIKTLCDDMSIISVANNSPKPCCLMAYTLSVCS", "length": 466 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8I6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMLALQILLLCQVVVGTVGNILLFVHNFSPILTDSRLRPIQVILINLAVANAFMLLLLTYSHDMIDLVPKNPPTDLKCKLAHFFHMVARGTNMCSTCVLSTYQFVTLVPGNWARVMFREISPKVVRYSCYSCWLFSVLNNAYIPMNVRGPKKSHNDSDSQGKRMCSISVVNVDMNYLQFSYDIIFIGIMVWTSVSMVIHLNRHHQRMHYIHNPNQSNRGHAETRAAHTILMLVVTFVSLYILNCICVLFHVSFVESRRWLRNVIEFLALSFPTISPLLLIFRDPRGPCSLYFNVGLEIHVTGKVITEEQ", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8L6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r132", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFFSVLSNIHIPIKVTGPQIIDNNTYDKSNLFCSTSGFIVGIVFLQISHDATFMSIMVWTSVSMVLLLLTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPNDPCSVLFKC", "length": 297 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8T0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFKNVLYFQTGLGVLANTVLLFFYVFIILGHRPKPTDLISCQLSFVHIMVVLIGGDILLADIFESLNIGNDFKCKTTFYLFRVMRGLSICITCLLSVFQAVTISPNTSVLAKFKQKVKKYMTHVFLCIWFFNLSFSTNQIFYVGGFTNVSETNQMQVTKSCSLLPMNYIIRGLIFTISISRDVFLVGVMLTTSVYMVIFLFRHQRQCKHLHSFSHPRESPEKRATQTIMLLVSFFVVLYWMDFIISFTSEMLRMYDPVILTLQKFMMYAYPTITPLVQISSDNRIIIMLKNIQSKCHPSFSLKDFFFFI", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8V7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r173", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSALNKALKTTEEVALQIILLCQVGIAAVANILLLVHNLSPNFAGPQLRPKHVILAHITVGNLLIILLTGFPSNIIVFVPRNPLNDLNCKLEYFIRLVARSANMCTTCVLSTYQFIVLVPGKWSRMILRGNTSTFVHYSCNSCWIISVLNNVYIPIKISGPWNTDNDTDLNSKWVCSMSGFELVMVFLRFVHDTMFISIMVWTSVSMMLLLYRHHQSLKHIHRSNGSLGLQPEARAAYTILMLVVTFVCFYLLDCMCIFFHISFVHFRVWLRHVNEILAASFPTLSPLMLIFRGPKKISAKGINTENAFINSH", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q9N3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r152", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFASKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFGSTSGFIVGMVFLQFSHDATFMTIMVWTSVSMVLLLHRHRQQMQHILTPNQDARGQAETRATHTILMLVVTFVRFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9QAN3-1", "protein_name": "Predicted gene 1979", "gene_name": "Gm1979", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRETREGRKDADLPPESNEGRRRWTWRMWMAHRQKTSPVPVTSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHELEMKNMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9QAS1-1", "protein_name": "Predicted gene 7073", "gene_name": "Gm7073", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIIAFTFTCFCLLHYNCMVEEVQPPGGLNKENMEAISSWVSKVSEYQPDMIVEDILETQPLLLNVDQTSAPLCPDKQPIPNNTAKSIQASSLEKPCIPSPNAQKSTKCINIEKSSTSCSAKYSNRPLKSNRPTMSSNPKRLCKSSHLEKTYNKCGLKKSNKLNHACKFANFNSSCSDKQATPWLSVLKSSAKQTTQSSSLISHDQITPTKPRRIKKPNLSHGHYEVKRSVNRRKPLLPMPTTAKVCRHYKDKCLVCNNSGFLLSDLSGEEKNNEEKLYGSMKVKPHHNPFYDTGYKYKTYEKSVSNDTMKECDSEDSNSEIVLICDISHDNITNK", "length": 335 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9QD93-1", "protein_name": "Granzyme K", "gene_name": "gzma", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDICRNLIVFHFLVFTFFKVTVCSDVSIVGGKDVKKALSWMVSIQVNQNHKCGGILIHKEWVLTAAHCKEDSYSSVTVLIGSLSLSKGSQRIAIHNYEIPETFNKKTKKDDIMLIRLSKKVKAKPYKIPKKEKDVQPGTKCVVRGWGTTDYKGKQASDKLQMLEVLVVDRVQCNRYYNRNPVITKDMLCAGNTQQHRGTCLGDSGGPLECEKNLVGVLSGSHGCGDPKKPTVYTLLSKRHITWINKILKQQFNSTRF", "length": 257 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9QLQ1-1", "protein_name": "Defensin, alpha, 35", "gene_name": "Defa35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTFVLLSALVLLAFQVQADPIHKTDEETNTEEQPGEEDQAVSISFGGQEGSALHDELSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1LPT0-1", "protein_name": "Gap junction protein", "gene_name": "Gjc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCCSFLRQLLARESQHSTPVGRFLLPVLVGFRLLILVSSGPGVFGNDENEFMCHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIYVAFTLYHVIGYWEVPGRNKEQEAQICKGGRCKDVSGAMSLKLLWAYVAHLGVRLVLEGAALGVQYHLYGFKMPSTFICREDPCIGSTTCFQSHPSEKTILLNTMFGISGACLLFIFLELVLLGLGRVWKTYRHKLPLFKNLSTSERSVRHKDTTDDLSVVETKEPF", "length": 257 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1LT33-1", "protein_name": "Cytochrome P450", "gene_name": "Cyp2b14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELGVFLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKGALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFIDTYLLHMEKEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVISSHRLPTLDDRIKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDANGTLKKSEAFLPFSTGKRTCLGEGIARNELFIFFTALLQNFSLASPVAPEDIDLTPINSGAGKIPSPYQINFLSRCVG", "length": 495 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1LYQ4-1", "protein_name": "Alpha-1-B glycoprotein like 1", "gene_name": "A1bgl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLLVLLEPLASLTLTCKVCEPSKDLHRILHLSSMETACTLSLALPPTLPSASLIFSASGVHTLILLRVRLNHSLILLSLIHTGPLPRPWLSANPVPWITPGLRTFLLCQGTVRDVVFMLRREGDDGNKEKEQGIFQVHEPGNYSCNYYTNTEYTPSKPSGTVTIKEYVIPPPPMLTSLESSTVDEPEMTQMSLLCVAPLSDVEFQLRQGEREMKVLIVSTSPERASFYLKLSDMGDHSPFTCRYRLNRMTAWSEDSKPVQLMWSDETLPEPVLTVEPSPHQSFEPGSTVQFRCTAPKAGLRSEAGLRFGLHLEDLYDHRLLQTQKSSGNETVFQLRNVSATDSASYSCIYTELTPPYSGSAPSDFVILRVNGPPPPPKLQALWTGKVFAGHDVVLRCQSDVTGVIVELLRDGKFVPYRILRVLNNYSDLGLHSVGPQHTGNYTCRYTSWLPEPVQSEPSNPVELLVEGMASGVVVVGFCLLIFPGLCILVNCAI", "length": 495 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M6N1-1", "protein_name": "Zinc finger protein 945 like 1", "gene_name": "Zfp945l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTASLVNVSKCLLTFRDVAVEFSMEEWECLNYSQKTLYRDVMMENYNNLLFVENHCKYKKVLDQDPNSIVHNVNIYEKAYECNELVKMTHESSQGTPFKTKHKDASLQISTLNRQKIGNTRDEPCKFKDCINFLNVFVIRQNQRIYIGEKEPTTIEYENHYNSKHEVMLKQSNSTGNKPHIFRKYGQCFKIYSSFSRYQNDHTSEKFYKCIKCRKSFLHLSQLKVHYKIHYRKYPCKCTACSKCFYHTFGFKRHYSIHPEVNTYKSSDCDKSFIYYSSLRKHQKIFGGERHYECNEGLRSLYTVFQPVYYYIPHIGEKAYKCSECEKCFTRKYHLTVHQRIHTGEKPYKCGECDKCFTRKYHLTDHQRIHTGEKPYKCSECKKCFTRKYHLTDHQRIHTVEKPYKCSECGMSFMKKYHLRSHQSIHTGEKPYNCSECDKGFTYKGHLRRHQKIHTGEKPYKCSECAKCFTENSKLRRHQRIHTGENLYKCSECDRCFIENNKLRSHQKVHIGEKPYKYSEYDKCLTQKGSLRSHQLIHTGEKPY", "length": 544 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M7A9-1", "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "AABR07026048.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANRLAHRPIQWRNFLSQDSLDQDTMRKKTILSNQTVDIPENVDITLKGRTAIVEGPRGTLRRDFNHINVELSLLGKKEKRLRVDKWWGNGKELATVRTICSHVQNVIKGVTLGFCYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVWMRTNVACSVSQAQKDELILEGNDIELVSNSAALIQQGTTVKNKDISKFLDGIYVSEKGTVQQADE", "length": 219 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M9J5-1", "protein_name": "Uncharacterized protein", "gene_name": "Esp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "ITFLPVTLFLIILLWPSMITEGRVLTQNQKELSISADHNKNHKSDLDKIEFQGQPNIQKAVEMTICASDKDQTLLEDQANANQDKQLYKDSHLLCGRSLDHIVK", "length": 104 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QDL3-1", "protein_name": "Novel nacht domain containing protein", "gene_name": "LOC560232", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEDKHTPGDLDLSTGCSSVHQNRAEAEPSCVSMKSDVSMDPPTNFKSGNTGPAVSSRKRKRAEAEPSCVSMKSDASMDPPLKFKSKNTQPAVSVDRDDQSGDLLQDSLQPEHDELQRVKEQHKTTMKNKHERLFEGINHGETQTLLNRIYTQLYIIEGESEGVNEEHEVIQMEKRARTKPSQHTPVYCNDIFKASAGAGHEVKIKKEKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKANQDVDFMFVLPFRELNLIRDHQYSLHRLLLDFHPELEDLEPKIYEQCRVVFIFDGLDESRITLNFSDEEKVCAVTESSSVAVLMWSLLKGDLLPSALIWITSRPAAAHQIPSRYIKRLTEIQGFTEPQKEEYFRKRISDEHQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLEEDVSAEIPQTLTEMYIHFLLIQINMRKQKYEERDPEKLLQSNRGVILKLAEVAFRQLMKGNVMFYEEDLIESGIDVTDALVYSGICTEIFKEESVIQQRKVYSFIHLSFQEFLAAFFVFYCHLTKKRELLELILGYSYDQYLQSSSEKSLYDLLSSAVDEAVRSSNGHLDLFLRFLLGVSLESNQRLFQDLLTHTEESSESIRRITQYIKDQIKSDDYFKRAAERFINLFLCLLEVKDQTLAREIQEFVKSDKHSEEELSPAHCSTISYMIEMSEEPLDEFELQKFNTSAEGRLRLTTAVRNCRRAL", "length": 725 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1QGM0-1", "protein_name": "Galectin", "gene_name": "lgals1l1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPTVLIQNMAFKVGQTLTLTGVPKPESPEFTIDIGNSSEDIALHINPRFDAHGDQCIIVCNTFQNDCWCEEHRDENFPFVQGEEFQIKITFTNEEFLVTLPDGSEINFPNRQGSEKYKYMNFTGQARIQGIEIK", "length": 134 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1QMQ9-1", "protein_name": "Uncharacterized protein LOC541480", "gene_name": "si:ch1073-398c20.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADIKQESDDIRIAEVFTLKQEDPEEQTDLLPLRKEFQGLDNVKEEEALVEEHQDITPAEKRITCSETENTTQKASEKTGSRSSFTCEQCGRDFAKQGTLNNHMRIHTGEKSFTCQQCGKGFTQKRTLRNHIRFHIEAESLSCQQCGESFTQKQDLTDHMRVHTGEKSFVCDQCGKVFLRKDGLEKHLKNHHKEKPHVCPCGKSFTDKTKLEEHTKTHTGEKPHTCDKCDECFSGKYDLIRHMRFHSAETPYICQQCGKSFALKRVLMTHVKIHTRDRPFLCKQCGKCFYRKDNFNRHVRVHTGEKPYACSECGKSFSERFQFNEHSRTHSGVKRFSCEQCGRGFNRKTELKRHMRVHTGEKPYMCPQCGKTYAFKTGFDIHMLHHNAEMPYICPQCGERFSVKQRFDVHMKIHAGNSDK", "length": 420 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1R1Q6-1", "protein_name": "Uncharacterized protein LOC641576", "gene_name": "zgc:152710", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLIWTQFGVKHKNVKCKVRVIHGEEGSWSSEEVREEPEVSSPPPSPECVDYYSVLGVSNDSNEEEIRKAYKRLALRYHPDKNSDADAEDKFKQIAQAYDVLTDPEKRNIYDQQGLTKGGVAPTCNKTDPSHNSKADAHSWHMFFNFDLDSDDDLFNPFTRNPLPHLSRHHGNKGGLKPAGDAEVHDLSVSLEDILMGVTKRVKLTRLRQTDKHTLKPEERVFDVEVKKGWKEGTRITFPNEGHQMLGHAPNDLAFVIKEKKHAHFRRDGSHIVYTCTITLREALCGCTVNVPTLDGQMKPLPCSDVIKPSSVRRLIGEGLPRAKNPAQRGDLLVEFQVVFPDRIPPSSKEIIKHSLGQC", "length": 360 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RA39-5", "protein_name": "[F-actin]-monooxygenase mical2b", "gene_name": "mical2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGETEEERTSQAGQLFENFIQATTCKGTLQAFSVLCRQLELNPSDHRGFYSSLKTAVTFWKAKGLWGKLDKRAGHKEYSKGRACADTRCLIIGGGPCGFRTAIELALLGAKVVVIEKRDTFSRNNVLHLWPYTIHDLRNLGAKKFYGKFCAGSIDHISIRQLQLMLLKIALIVGVEVHVNVEFVKLLEPPEDQSTDGQGWRAEIRPADNPVSDYEFDVIIGADGRRSTLDGFRRKEFRGKLAIAITANFVNRNTTAEAKVEEISGVAFIFNQKFFLELKEETGIDLENIVYYKDNTHYFVMTAKKQSLLDKGVIINDYIETERLLAFDNVNQEALLSYAREAADFGTNYQLPSLDYAINHYGQPDVAMFDFTCMYASENAALVREKSHRQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMIKGWAQGKEPLDLLSERESIYRLLPQTTAENISKNFEQYTIDPATRYPNLNSSCVRPHQVRHLFISGEQDLSSLERSGQTRRSVSISRRESEVRPGRLLLWCQNQTQDYRGVNVTDLNTSWRSGLALCALIHRQRPELIDFDSLNEADCAKNNQLAFDVAEREFGIQPVTTGKEMDAERGPDKLIMVLYLSKFYEMFHKSTQSVTGLPKEIDANNGDCSSKTANSLYNSINHARKRIPKLDKKLEESDVNRKRKKASSHHEELMSCQTAPPAGEREEQKENKVRSMATQLLARFEENAPSCALRRQSDSESDSDADRPVSLDLTENPRFARPKIEPTHPSTTPDKAKWQPSPYLRLLESNTRSETLHTEHYVESQSSHRLTEIQSECQYSSVSSAYKSSERRPRSPLIPFTPTLSPMMHCLQQLEEQVIQQRKREPLNRKSIKERAQKLSSLFTGNPAQPQTDESSPAVSPSSPPQTIPESSTLSCLLSPAPSLTHKQCSEASETHLKADKHTEIRRVERLDPSKQRTVGKVSSAIGVKAATLAILYETDHRPNNPITLSLTEARRCAESGLVSVRKEFSASLGGSDTCVFCQKRVYIMERLSAEGFFFHRECFRCHICGCSLRLGAHTFDSQQGTFYCKMHFSQRKTSTRHRRGEIQDGGIRSSSITISNHTSTDGTRGQPSGGEFDSSTQQDLQTLPDSKEIISVSEVKDSSKKADPADSAPACPDSPLQKVKRSTAKGEITNKNILWKKKIRSTLPLVLMKKFHRGKPEDKTEVLAEEDGNSDFEEIHESLSSKKPSNPSTDSNCLPTKDNSSTPLDEIPKIPLYRTHVLPEYPKPSSSSPEPIVTSISSDPISFSPKKKLTLSLSEKEKLLNWDLTNPGKSGAEEQQQQHVKPSISLQHDHPEPTHPQPEPAPPLFGFQQWANNLRKSFSKGSNPVVLRRNRPMKARPLSEGSFNVGAVFQDEERCGSLVDEGEARPRTESEIASLLEQVALGSKTSRGTKDDMASLPPRKLNFFSSLRIKRVEGAEQSRGEGQKDILSILSRFRNKASAQQQQQQKSNSSSEDEQEPKLTHSGALQKKKEKIAIRQTKSDELKRLHRAQVIQRQLEEVEEKQRSLEEKGVALEKVLRGENGDDGSTDEAALLQTWFKLVLEKNKLSRYESELMIFAQELELEDTQSRLQQDLRRRMATEDCEKSASELVEEQNILVEIMKVVEKRDKLVSLLEEQRLKEKAEDRDLESLILSRGYQFHWT", "length": 1679 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RXL1-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152495", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFTICNDSHSDFILLGFSDKPYLEKILFWVVLIFYCLTIIGNLVIILVSLKDPKLHIPMYYFLSNLSLLDLCFTSSCVPQMLVNFGGPEKTISYIGCAIQLYVFLWLGATECVLLVVMAVDRYVAVCHPLQYTTIMHPKLCLELAILAWGTGLIQSLTQSPATLQLPFCSNRRLYDIVCEVPALIQVSSADTIYNEIQMSIASIILLVVPLVIILSSYGAITKALLRVKSTEGQKKAFGTCTSHLLVVFLFYGTVTAVYLQPKSHYAHEQGKFLTLFYTVITPTLNPLIYTLRNKEVKGALIRLGKKTWDDLCWTIA", "length": 317 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1RYD0-1", "protein_name": "Transcription elongation factor A like 3", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRQVKHLRSGSLPTPGLSVTSPSPTARPATPRTACLFPALCKTRKGEGTCPESLQDKKRRKNLNMEKLCKENEGKPESEGKPEDEVEPDNEGKSDEEEKPEVEGKSAHEGKLQNEGQPEDEGKPEDEGKQEKQGKSEDEGKPPGEGTMESQAKPESEPRAAEKRPAEDYVPRKAKRKTDRVTDDSPKDYEEDLQERHLGSEEMMREGGDLSRAQEELRKRQKMGGFHWMQRDVQDPFTPRGPRGVRGMRGGGRSQRGLHDIPYL", "length": 264 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1RYD7-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258723", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "LLVVVLVTYLLTLVGNTVIILIASIDPNLKTPMYFFLTHLSLVDICLTTSIVPQLLWNLRGPAKTITTLGCAVQLYVSLALGSTECVLLAVMAFDRHAAICKPLHYAAVMNPRLCQALAGVAWLSGVGNALIQSTVTLWLPRCGHRRLHHFFCEVPSMIKLACVDIHTNEVQLFIASLVLLLLPLALILTSYGHIVKAVTRIKSVQAWRKALGTCGSHVMVVSLFYGTITAVYIQPNSSYAHTSGKFISLIYTVLTPTLNPLIYTLRNKDVKGAMRRLFRRDLGS", "length": 285 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S4M2-1", "protein_name": "Small ribosomal subunit protein uS13", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLVILEKFQHILRVLNTTIDGWQKIAFATTAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVEHVITIMQNPGQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLHEDVERLKKIRAHRGLRHFWGLRVGGQHTKTTGRRGHTVGVSKKK", "length": 152 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S6C0-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNCLTPHTSEDLLVPASATHLGGRRRRARSRERRPRDQVPGWAPAAPLVQEEQVRVPQRISQIQCLPKGVYKRDGSQEKMEQEECAICTLDFVCGDPIRSLPCKHFYHLGCIDEWLTRSFTCPYCRGPADGPQPSSRDTP", "length": 141 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S7I2-1", "protein_name": "Beta-defensin", "gene_name": "DEFB125", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNLLLTFMICGLLTLVTKAGWNVERCWSYNIGHCRRRCLHLERYKHLCMNKRACCIPLSSDDPYTQWPLPPEDQTVGMKTPYFRPVSPGSELDDQITITITVDQESTGTEQDIEGTAISFQASTPIPENIEDTKFSDKANTLNLHKL", "length": 147 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S7N4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152708", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDQTNSSVVTEFVLVGLTQSLGMQFLLFLLFSTFYVGIILGNLFIVFTVISDSHLHSPMYILLANLSLIDLGLSSTTVPRMISDLFSDCKTISFHNCMIQMFFIHVTGGVEMVLLIAIAYDRYTAICKPLHYLTIMNPQMCMLLVVAAWITGVTHAVFQFAFVINLPFCGPNNVGSFYCDFPRVIKLACIDNYGLEFVVTANSGFLSTGTFFLLVVSYIFILVTVRQHSSKDLSKAFFTLSTHITVVFLFFLPCMFLYVWPFPTKSLDTFLAIVDFAVTPVLNPAIYTLRNRDMKVEMRRLSRQVISSREMT", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SBB9-1", "protein_name": "DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHALPAFESFLLFKDEKITIHKDTKAPNACLFTIDKEDHTLGNVIKSQLLKDPQVLFAGCQVPHPWEHKIIVPVQTTPDYTPQEALLNVITDLISKLSLLEERLRVAIKDKQEGIECWTGRGPAWPGPALTLALLQAPCG", "length": 140 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SBV4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100154723", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESENITVVTEFIFVGLTQSRNIQLLVFVLVFIFYLIILPGNFLIILTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEMLLLVVMALDRYIAICRPLHYSTVMNPRACYALSLAQWLGGFVHSIIQVALILHLPFCGPNRLDNFFCDVPQVIKLACTDTFVVELLMVFNSGLLTLICFLGLLASYAVILCRVRGSSSEGKTKAMSTCTTHIIVIFLMFGPGIFIYTRPFRAFPADKVVSLFHTVIFPLLNPVIYTLRNQEVKTSLKKLLINN", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SJ79-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259717", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTKGTEFILLGFAGQHKSWPVLFIVFLVTYVVTLVGNIGMILLIKIEASLHTPMYFFLQNLEEKVDLCYATAITPKMLQNFVWTEHSISFIGCMVQLLTYGAFATSDCYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLVIGSYFMGFLNASVNTSFTFQLNFCKSNKINHFFCDAPPILALSCSSIYFSIMLLAAFVGFNLTCTVSVVIFSYVFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMFNPLIYSLRNQDVREALKGVGKQCF", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SLL7-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSSISKFLLLGLPIQPEHQGMFFVLFLVMYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLALTDVSFSSVTVPKMLMNMQTQDQSIPYAGCVTQTYFFIFLACIDNLLLAVMAYDRYVAICHPLHYAIIMREELCLCLLVLSWLLSCAYALTHTLLLAQLSFCADIIPHFFCDLDALLKLSCSDTSLSELVTFTAGAAVVIFPFIGILVSYGHIGLSILRVPSTKGICKALSTCGSHLSVVSLFYRTSMAVYLSSSGQFHDKDIIVSVMYTVVTPMLNPFIYSLRNRDMTLALGILFRNINIFSK", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SMZ6-1", "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "HSPE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTRVVLDDKDYFLFRDGDILGKYVD", "length": 102 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SRB7-1", "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVVQKSGEKKRGRSAINEVVTREHTTSIHKRIHGVGSKKRAPRALKEIRKFAMTEMGTPDVRNDTRLNKAVWAKGIRNVPRRICAPLSRKRNEDEDSPNKLYPLVTCVPVTTFKNLQTVNEDEN", "length": 125 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SUB9-1", "protein_name": "Multifunctional fusion protein", "gene_name": "IL1B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATVPEPAKEVMANNGDNNNDLLFEADGPKEMKCRTQNLDLSPLGDGSIQLQISHQLCNESSRPMVSVIVAKEKPMNPSSQVVCDDDPKSIFSSVFEEEPIVLEKHANGFLCDATPVQSVDCKLQDKDEKALVLAGPHELKALHLLTGDLKREVVFCMSFVQGDDSDDKIPVTLGIKGKNLYLSCVMKDDTPTLQLEDVDPKSYPKRDMEKRFVFYKTEIKNRVEFESALYPNWYISTSQAEQKPVFLGNSKGRQDITDFTMEVLSP", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F2Z5L2-1", "protein_name": "Histone H2A", "gene_name": "H2AC18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK", "length": 130 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4IWB9-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 28", "gene_name": "CYP705A28", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIMGRSCSEKNGEAERVRGLVIESLALSPKIFLGMIFHKPLKKLGISLFQKDIKSVSPKFDELLEKFLVEHEEKMEEDHYKANDMMDLLLEAMEMRMQNVNLCIKRVSNTKARKPPILFRYGKYSNNSLLLQELLVAGTDTSALATQWTMAELINNPTILERLREEIESVVGNTRLIQETDLSNLPYLQSVVKEGLRLHPPASISVRMSQERCELGGFYIPEKTLLVVNTYAIMRDPNFWEDPEEFKPERFITSSRSEQEDEMREEVLKYIPFSAGRRGCPGSNLAYVSLGIAIGVMVQCFDWRIKGEKVNMSETAGTIMLAMAQPLKCTPVPRTLNLLPSSLHIPSS", "length": 348 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4J311-1", "protein_name": "Zinc finger (C2H2 type) family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLDGVELLLDLREMVSQSGFEKSTTCSGVIALRSNLQSKSSHKCKICGKSFECYQALGGHQRIHRPIKEKLSKQEFSEVYPRKSKLQKRPESSSSCYECKVCGKIFGCYRGLGGHTKLHRSTKRELASTQDENSLLDSSEAKKIVSQPSSFKVSQEEKFLHCVELKQDFSEPLSHSGALPSTLRSKLQTKTQWKSSCHCKICGKSFVCSQGLGNHKRVHREISGKLACKRKYTEDYNPFSDSLKAKKIVKKPSSFEVSQEEKILHCVELKQDFGELLAHSGFDKSISCSKSIKVKKVARKNEKTEDSTSLFGVFVGEMSQRLHGCKTCGRKFGTLKGVYGHQRMHSGNHNRIEDENGLERIWGLKKKSRVCSVSAFDRFKGSSFMAEIEKHEVIEAALNLVMLCQGVYDFASISNLPLGDGFMDLELKPCPLRRKLQKKSRSSYKCSICEKSFVCSQALGSHQRLHRWKLVPKPEYIEDDSSLLDSSEAKKIVSKPSSFEHAQEEKILQCVEPKLEFHEQLAHSGFDKFDTCSKIRFSALPSPPEAKKIVSQPPSFEVSVDEKILYRAEPKLNFSEPLAHSCFDNSSSYRSIICGKSFVCSQALGGHQTLHRSIKGQLAGTEDGNSLSVTDSEASKIVAQPSSYKSQGI", "length": 650 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4JLV4-1", "protein_name": "Protease inhibitor/seed storage/lipid transfer protein (LTP) family protein", "gene_name": "DHYPRP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASTTIILFLSFSIIPLLTIVRADNHSVYCPPPPPCICICNPGPPPPQPDPQPPTPPTFQPAPPANDQPPPPPQSTSPPPVATTPPALPPKPLPPPLSPPQTTPPPPPAITPPPPPAITPPLSPPPPAITPPPPLATTPPALPPKPLPPPLSPPQTTPPPPPAITPPLSPPLVGICSKNDTELKICAGILAISDGLLTTGRAEPCCSIIRNVSDLDAVTCFCKSVGAPRFSLSPNFGIFFKVCGRRIPQGFSCPGPSPTISPPPLPPQTLKPPPPQTTPPPPPAITPPLSPPLVGICSKNDTELKICAGILAISDGLLTTGRAEPCCSIVRNVSDLDAVTCFCKSVGARRFSLSPNFGIFFKVCGRRIPQGFSCP", "length": 375 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4K5R6-1", "protein_name": "Cell division cycle 20.6, cofactor of APC complex", "gene_name": "CDC20-6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMKSIALALCLTHHSPMVLSIVDYGDSQEKTIDSLWKKPHGSDLTWSGFSRVGVTEAYFAVPVDHFLTNPPSLRLSQTIYCRRGSSYVETEKVEEEDRDDFLKQVWFLTDNLVFFFVDIEEYIVIEQLGDTVYLWDASSCYTSKLVTIDDENGPVTSINWTQDGLDLAVGLDNSEVQVWDCVSNRHVRTLRGGHESRVGSLAWNNHILTTGGMDGKIVNNDVRIRSSIIGTYVGHTEEVCGLKWSESGKKLASGGNDNVVHIWDRSLASSNPTRQWLHRFEEHTAAVRALAWCPFQASLLATGGGVGDGKINFWNTHTGACLNSVETGSQVCSLLWSKSERELLSAHGFTQNQLTLWKYPSMVKMAELNGHTSRVLFMAQSPDGCTVASAAGDETLRLWNVFGEPPKTTKKAASKKYTEPFAHVNHIR", "length": 428 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F5H284-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4D", "gene_name": "PPIAL4D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEATEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F6R3J9-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1G", "gene_name": "Speer1g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKESSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMSITQNKKNKEVEIDWALIEKYLVDLNLNGQTGADQQP", "length": 157 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6X687-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1A", "gene_name": "Speer1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKQSSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMPVTQNQKNKEVEIDWALIEKYLVDLNLNGRTGADQQP", "length": 157 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6YNI8-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRCRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILVGLQDYQDNKADVILKYNLDEARSLKAYGELQEHAKINETDTFGPGDDDEIVFDDTGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7AMQ8-1", "protein_name": "Exocrine gland secreted peptide 8", "gene_name": "Esp8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKVSAMTSFPVMLFLIILLLPSICSEERTQADPTISADNKKNFKTVVDLTDCQCERNFIESLESTLPASNQDQTLFENMTNQHKLNLSKMLSVLSKCCTQKQQVDTVHFRRMPHRIQSTKQNNYKKQVLYPMQEFMNLTRDVLVSRYV", "length": 149 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7C9P2-1", "protein_name": "F-box and WD-40 domain protein 25", "gene_name": "Fbxw25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLPSLPMLKILSYLDAYNLLQAAQVNKNWNALASSDVLWRKLCQRRWHYCDMVTLQLQGKETWKQFFIYRIWQEHAKTRAKPEDFTYKEIPVECGFYGYACYISGHGLTRNGQGKSVICMVSSKNTISTWDIHKSVITWVSPVQPASINLLTTLPDMHIAVTVDIQSTIKLWDCHNREALATNNLESPCKSLKAVISKDGPIVLVGDTLGNLYIFRIPDLHLISTVNVFPYGFDEIDCSPQKKWVLLSKNYPHILPKVFYMSSLLRTSEFSAPVSTILEFSLCQGAFWTPRREDRITLMSRSGFPQITKFETFDMKLEGIGNKVAVQGKLIASFFLPYYEESPNWIGVSDKDVIVCSTHFFLLLFTINGLHLQTFQYCPETIVRLCVDPVHVIVTCNNGSLDVYAWEERSLLLRKCYRLQNKRPLPLYGFINNLLCDDVSIVQLMRDGHGPYSLIAYALNICS", "length": 466 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7ELE5-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "gene_name": "Ndufs7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RRTVVYTARARSQEKSGSEPLSLWFRFPLVSIWALDQNRNSLEDGPQRLSEGRGQDGGAGGSWLALCTDPGSAHRHSGSAAQSPPECGSHWEPEQSAVSKAGAGAVVPKPSHLPRSRAEYVVTKLDDLINWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQADVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQRKIKREQKLKIWYRR", "length": 271 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F7F947-1", "protein_name": "Beta-defensin-like domain-containing protein", "gene_name": "Spag11b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLSQRPPNVFRHVVDFLKKNQTHITQACSGNSGGRKASSSDLCGCALCLEAPSPHSQLSYKRACSSCPPTRGSSVPAVPSTAMKQRLLPSFVNLLLAALLLPGKAETWLRSWTQALSAVVTLGSSSASSINHLVTEPPSSPQDEFPAQGGNGSGLLHHRVKRFPPRTPPYHEPGPNYQIVNCKKNEGFCQKYCNFMETQVGYCSKKKEACCLHPF", "length": 216 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F7FNC4-1", "protein_name": "Interleukin 36, gamma", "gene_name": "Il36g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSKYPHSPCTASGKETPDLGQVSDVDQQVWIFRDQALVTVPRSHTVTPVTVTVLPCKYPESLEQGKGTPIYLGIQNPDKCLFCKEVNGHPTLLLKEEKILNLYHHPEPMKPFLFYHTLTGATSTFESVVFPGSFIASSKIGKPIFLTSKKGEHYNIHFSLDII", "length": 164 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8VPX6-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4A1", "gene_name": "Speer4a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVNGRETREGRKDANLPPESNEGRRRWTWRMWMAHRQTTSSVPVTSKKQFEKEEKELIKKIQLTTKETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHNLEMENMEARENKQEFKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIQERLVELNLSCKDEQEKTSNLETQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHTQNPPSSSDESSSDESSYSTCPAWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F8VQM2-1", "protein_name": "C-C motif chemokine ligand 26", "gene_name": "Ccl26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFFDLGLLVLLAIFLSVQLGVATCGSSIAMSCCPNFSYYVIPWSWVYSYKFTDKSCTSDGVIFFTKTGKQFCVQPGAKWVQRFISLVNTRNHL", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3GSG1-1", "protein_name": "Ferritin", "gene_name": "LOC100767129", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGFLRKSHRRQRHRCPLRVSRATVAYPLVFMTPPIISPPSQVRQNYHFDCKTAVNNHVQLQLHNSSVYLAMAFYFDSEDVAQKNLASFFLNKSHECTAQAEMFLELQNQRGGRISLGSIREADRNNWLGGLQAMECALQLELSTNQSLVALHQLASSKSDAHLCSFLKNHFLTKQVEVLKEISGYVTKLRQMGSPDDGIAEYLFGKLTLDDNKGK", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3GWA3-1", "protein_name": "60S ribosomal protein L18a", "gene_name": "LOC100764432", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKASGTLREYKVVGRCLLTPKCHTPPLYLMRIFALNHVVAKSRFWSQLKKMKSSGEIVHCGEVRPEVPLQVKNFAIWLHYDSRNGTYNMCREYWDLTVTQCYRDMGAQHCARTHCIHIMKVEEIASGKCQRPAVKQFHDSKIKFLLPHRVLRCQHKPHFTTKRLNTFF", "length": 168 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H156-1", "protein_name": "Prefoldin subunit 4", "gene_name": "LOC100773780", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVATMKKAAAEDVNVTFEDQQKINKFARDTSRITEQKEIEVKKNHLQNLEDTFNDIMLADGDCFMTQYLIRDVLISHSQEEAQEMLEEAKKTLQEEIDALESRVGAIQWVLANLKVQLYTKFGSNINLGVDES", "length": 133 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H2T6-1", "protein_name": "Histone H4", "gene_name": "LOC100757199", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H8X2-1", "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase gamma", "gene_name": "Agpat3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGLLAYLKTQFVVHLLIGFVFVVSGLVINFTQLCTLALWPISKQLYRRINCRLAYSLWSQLVMLLEWWSCTECTLFTDQATVDHFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKRELLCVPLIGWTWYFLEIVFCKRKWEEDRDIVKEGLQCLSDYPEYMWFLLYCEGTRFTETKHRISMEVAASKGLPPLKYHLLPRTKGFTTTVQCLRGTVAAIYDVTLNFRGSKNPSLLGILYGKKYEADMCVRRFPLEDIPADENDAAQWLHKLYQEKDALQEMYKQKGVFPGEPIKPARRPWTLLNFLCWATILLSPLISFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTEIEKGSSYGNQELKKKE", "length": 376 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HAB3-1", "protein_name": "40S ribosomal protein S15", "gene_name": "LOC100759804", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEVEQKKKRTFRKFTYCGVDLDQLLDMSCEQLMQLCSTRQRLLLNCSLWRKQHSLLKSLRKAKKKVPPMEKPEVGKTHLRDMIILPEMAGSMVDVYNGKTFNQVEIKPKMIGHYLGEFSITYKPVKHGGPGVGATHSSRFIPLK", "length": 145 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HDI6-1", "protein_name": "Lipid transferase CIDEB", "gene_name": "Cideb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEYLSALNPNGLLRSVSTMGSELGRRVWNSGPPPQRPFRVCDHKRTVRKGLTAATRQELLDKVLETLLLSGVLTLVLEEDGTAVESEDFFQMLEDDTCLMALERGQSWSPRSGMLSYGLGREKPKHSQDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKKVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGAERWQWHKQNHLRS", "length": 219 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HDS5-1", "protein_name": "Histone H3", "gene_name": "LOC100773314", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 136 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HGI3-1", "protein_name": "PHD finger protein 6", "gene_name": "Phf6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSSIEQKKGSTRQRKCGFCKSNRDKECGQLLVSENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEETFNEHELEPSSPKTKKKSRKGRPRKTNFKGLTEDSRSTSSHGTDEMESSSYRDRSPHRSSPNDTRPKCGFCHVGEEETEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGRLAIDQQLTQQQLNGN", "length": 364 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HJW3-1", "protein_name": "Calcium homeostasis modulator protein 6-like", "gene_name": "LOC100774768", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKFKAVLDLQSKHRSALGYGLVTLLTAGGEKIFSEVVFQCPCSATWNLPYGLVFLLVPALALFLLGYALRTRTWRLLTGCCSWSASAQSSSGLQRVFVCAQISAAAALPPLTWVAVALLGGSFYQCAVSGSEAMARHLCKGRDPSCAAKLPQVPCKKQEAEMQDILSQLKAQSQVLGWILIAAIIILLLVVKSVTRCLSPVSYLQLKFWEIYLEKERQILQGEAMEHATQLAKENVRCFFDCTNPKDCSTPSSKAWQQISALYTFNPKNHFYSMLHKYVNRKDMSGSLRSVEGDAVVPVLGFVDASGMATTHGV", "length": 315 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HQ40-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B", "gene_name": "LOC100767578", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDLGSSSDSAPDCWDQVDMEVPGSAPSGDGFTSASTAAAEAAEAEAQRQHLSMAFSSQLNIHAKPFVPRVSAAEFVQSFLPGSAQPPAPTTSSSDETCTGAGDPQGKRLGWGAPVEPSKDGPLMSWEGSNSAVTMELSEPVVENGEVEMALEESWELKEVSEAKPGGSLGDSGPPEESGKEMMEEKEVIRKSKSMAIPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 631 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HQN5-1", "protein_name": "Transcription factor 19 isoform X1", "gene_name": "Tcf19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLPCFQLLRIGGGRGGDLYTFHPPSRSGCTYRLGCRADLCDVALRPQQEPGLISGVHALLHAELQGDDWRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGPEGQAGTSSSEFYFMFQQVRVKPQDFAAITVPRSRGEAGTGFQPMVPSQGAPQRPLSTLSSAPKATLILNSIGSLSKLQPQPLTFSRGGGRPQSLAVPTQPGEVGASPPAPPTRNRRKSVHRVLAELDDENETSLSPLSVLMEPRKKLRLEKAALVSSGRD", "length": 266 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HWQ5-1", "protein_name": "Zinc finger protein 219", "gene_name": "Znf219", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGSRPRILVGHLEPSPPAFDGELDLQHYSNGPGVSTGSPGMGAVGWSETRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREAQLGRARSSGGMQATPATEGLARPQVPSSSAFPCPFCKGKFRTSAERERHLHILHRPWKCSLCSFGSSQEEELLHHSLTAHGASERPLAATSTPEPQPPPQPEPRSALEPEPEPEPRPEPEHEANPAPTPAPPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGSTPARAPQPPDMSLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSVRAGEVRPNGEGADPGAGRSYGGGFRPLPSALPNRARRHRTEEPEEEEEVVEAEEESWARGRSLGTLTSLHPHPGEGSGQSAPAVGAQARPTGTQEENGLLVGGARSEAGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSSAGPGPPPEPPPPSPRGAASLQPQSGAKPTQASATWVEGTASTRPSSSGTGAGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGSGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRQPRADTSPPYVRAPSGETPPSPPLEEEGSPGLSRSGEAGLGGQER", "length": 725 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3I071-1", "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "LOC100753244", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKIKARDLRGKKEELLKQLDDLKVELSQLRVAKVTGSAASKLSKIRVVQKSIVRVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMHRQLTKHEEKLKTKKQQRKERLYPLRKYAFKA", "length": 122 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3I1Z3-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "Ddit4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPSLWDRFSSSSSSSSSSSSGTPATDRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC", "length": 231 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IAH8-1", "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "LOC100755128", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASNNTASIAQARKLVEQLKMEANIDRIKLSKAAADLMACCAAHAKEDPLLTPVPASENPFREKSFCTIL", "length": 70 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IG76-1", "protein_name": "Olfactory receptor 7E24 isoform X2", "gene_name": "LOC100765597", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYILALFGNLLIILTVSSDSHLHTPMYFFLSNLSMIDIGYISTTVPRVIVDIQTHCPVISYVGCLTQMSLIIIFACMDDMLLSVMAYDRFVAICHPLYYQVIMNPSSCGVLLLGSFLLSLVNLLLHYVAVLSFSNCEDIFEISNFFCGPSELFKLACFDTFTTNIVRYCAGALFGLLPISGIIFSYFKIVSSIMRSSSSSNGKWKTFSTCGSHLSIVCLFYGTALGMYFSSSLSLSPKTNAVASVMYTVVTPMLNPFIYSLRNKDIKTALRKILSRTF", "length": 278 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IGD7-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100770882", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGANSSSLTPEFFVLNGIPGLEDAHVWISLPFCFMYMIAVVGNCGLMYLIGHEEALHRPMYYFLTLLSFTDITLCTTTVPNTLCIFWFNLKKIGFKACLAQMFFVHTFTATESGMLMLMALDRYVAICYPLRYGTILTNPVIAKASLATFLRSVAFILPFTFLTKRLPYCRGNTIPHAYCDHMSVAKISCGNVKVNAIYGLLVALVVCAFDIFCITVSYTMILRAVMNLSSADARHKAFSTCTSHICAIVITYVPAFFNFFTHRFGGHTIPHHIHIIVANLYLLLPATMNPIVYGVKTKQIRESVIKFFSGDKSGITEIKGLQNK", "length": 326 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3INQ1-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100763177", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFCNTSTPGHSTFLLTGFPGLEASHHWVSIPINLICVVSILGNSIILFLIRTDPALHEPMYIFLSMLAASDLGLCASTFPTMVRLFWLGIRELPFDLCAAQMFFIHAFTYVESGVLLAMAFDRFIAIRDPLHYATILPHSAVAKVGAAVLIRAILLNLPGPILLRRLLFPQVSVLSHCYCLHCDLVGLACSDTRINSLVGLVSILLSLGLDSSLIMLSYVLILRTVLSIASPGERLKALNTCVSHLCIVLIFYLPKLGLSVLHRVEKHSYPALAVLMANLHFLVPPFMNPVVYCIKSKQIRQGFLKRFQQKRVDVS", "length": 316 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3MYE2-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRQEGKTDYYARKRLVIQDKNKYNTPKYRMIICVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAVAYCTGLLLACRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGALTCYLDAGLARTTTGNKFFGALKGAVDGGLSIPHSTKQFPGYDSESKEFSAEVHRKHIMGQNVADYMRYLTEDEDAYKKQFSQYIKNNVTPDMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLGQENDRVAQKKASFLRAQERAAES", "length": 295 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3MZM9-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC107131211", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTRAEFKQTKLQELRRRLLIIVIGTLITGYMVTCTCLLHYRCDSKEAHKAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKPTWPPSLQCRVKPTKTPLPYPKNQSFPEHSSADKLTKRQRYLKLKCPASAGRAEILSRPQPVKFCRCYKEKCLVCRAVSEPFITHVSEANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSPNN", "length": 361 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3UW31-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r176", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKSVKTTVEVTLQILLLCQVGVGTVVNIFLFVHNLSPFLNGSQQRPIKVILANLALGNTLILLFAFPNNIRVFIPREFPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQFVTLAPGTWGRVMLPGRAPNFLRYTCYSCWLFSVLNNAHIPMKVSGPQKTHNDSNSKSKWVCSTSGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSTNQKLRVHAETRASHTILLLVVTFVTCYLLDCICTVCNISFVDSRVWLRRVKEILSVSFPTFSPLLLIFRDPKDPCSLLFGC", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3UY92-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r158", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQLLLLCQFGVGTVAKVFLFVRNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLESFSHLVARSTNLCSTCVLSFHQFVTLVPLNRGKGKLVLRASVTNMASYSSYSCWFFSVLSNIHIPIKVSGPQIKDNNTDSNRKLFCSTSGFSVGTVLLQFAYDATFMSIMVWASVSMVLLLHRHRQRMQHILTPNQDARGQAESRATRTILMLVVTFVSFYLLNFICIMLHALFMHSHFFVRLVSEILTAVFPSISPLLLIFRDPKDPCSVLFNC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3V9M0-1", "protein_name": "Cystatin S like 1", "gene_name": "Cyssl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACLLYTQLFLLNTFILFLNLSLNPVLGQILAGIEKSIIEEEGALEALNFAVSEYNENNSDLYLSRVVEVKTVKTVQQQIEAGKTLLFDVILGKTACLKTQDDLSDCPLNEPTDLQEREFCSFEVHLPDWANAINLLSSICNRI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3X693-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "RVFLPLLLLGVILPGGDNEDGPTSFHLIQISTFVNNTWAQNQGSGWLDDLQIHGWESDSGTAIFLKPWSKGNFSDDEVTELVDLFRAYFIGFTREVQDRVNEFQLEYPFVIQVTAGCELHSGEAIESSLRGALGGLDFVSIQNHSCVPAPDGSSRGQKFCALTTQYQGISDIIERLLSETCPRYLLGVLDAGKAELQRQVKPEAWLSSGPTPGPGRLLLVCHVSGFYPKPVRVMWMRGEQEQPGTQQGDLMPIGEAAGLNCRVKHSSLGDQDIILYWGHPTSIGLILVAIIVPSLILLICLAFGVLRFMGSHRIGHD", "length": 317 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3X9Q9-1", "protein_name": "Predicted gene 6526", "gene_name": "Gm6526", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGDQGETRPRQKESAIPSCKKRRMKSFWGRHMSAGKKSSQNCNITNHMKNMNKLEDMKFYIRKINAKRLELFPILDIDMNTDLNYRMNIEFTIIKSQHEKTMLDMEKMTQSISDTIETYKEFIEDKDSYSFTHSYLLKECNQLKEKVRMLLNENRKLLVEQADQEASYGEEKRFCDESSKNIHPKC", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G5E8X8-1", "protein_name": "Oocyte maturation, alpha", "gene_name": "Omt2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTLVFTKVHLESWVYKGLRGQHDSILELLKENLHHYLCIEFDEGLNDTVVYIIGFKFFAMFAMFVIVSLACNLRTKRNRARAWARGLQSPVWWNRRYFI", "length": 100 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BJ46-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLSFMSSLLENILYFQAGLGVLANIFLLVFYIFIILGHRPKPMDLISCQLTFVHIMMFLAGENFWLANIFESLNVENDFKCKATFYTKRVMRGLSICITCLLSVFQAVMISHRNSLLAKFKHKLKIYMINALFYIWTFNLSLSSNLIFYVGGFTNMSQTKQLKVTKSCSLIPMNYIIRGLILTVISSRDMFLVGVMLTTSTYMVIILCRHQRQCKHLHSTSHLRASPEKRATQTILLLVVFFVIMYWVDFIISSTSILLWMYDPVIMIVQKFVVNAYPAITPFVQISSDTRVIRVVKNWHS", "length": 303 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BJ88-1", "protein_name": "Vomeronasal 2, receptor 3", "gene_name": "Vmn2r3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMAIRKKCLILELTVFLCVELYAQYEDQNMTCRLMRKFNLTGYVEAENHHFVIGGQFPVHYRTIPTSDSDEEPESPMCEGFNFRGFRWMKTMIHTIKEINERKDILPEHTLGYQIFDNCFSTTKAMESSMVFLTGQDEYKPKWRNSTGKYLIGIIGAGGSTMSLAGARILLLNDVVQVGYASSSSILTEYLNVYRTIPSDKFQTEAIVNLIRHFGWVWIGAIASDDDYGKHGVKSFRKILETNNLCIAFSETIPKVYSNEKMQIAIDAVKSSTAKVIVLYATDFDLSPFVLEVIHHNIAHRTWIATEAWITSALIAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKDPNDVLTIEFWQTAFNCTWPNSSVPYNVDHRVNMTGKEDRLYDMSDHLCTGKEKLKDLKNTYLDTSQLRITNNVRQAVYLMAYGLDRLIRVLIKEYREYLLHPKILAFMSYKLFEYIRKVKFTTHDGRKIELNVHGDIENGYYDILNWQMDNTGDIAIVKVGEYKFTRSKYELVLPKNSTLFWNTESSRLPDSVCTKVCPPGTRKGFITGQPVCCFDCIPCEDGYVSEKPGQRLCNPCSEDDWSNAEKNKCVPKHVEFLAYEEALGFTLVILSIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQISLVITVLSTMLFIGKPCNWSCMARQVTLALGFCLCLSSILGKTISLFFAYRISISKTQLISMHPSFRKLIVLLCVFGEIGVCASYLVLKPPSMFKNIERQNVKIIFECNEGSVEFLCSIFGFDVLLALLCFVTTFMARQLPDNYYEGKCITFGMLFFFIVWISFVPAYLSTKGKFKVAVEIFAILASSYGLLGCLFLPKCFIILLRPKRNTDETVGGRVPTVDRSIQLTSASVSSELNSTMVSTVLDE", "length": 909 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BKT1-1", "protein_name": "piRNA-mediated silencing protein C19orf84 homolog", "gene_name": "Gm52993", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDELEDGALSNGDNLSLPSAGTESWPTSATPGLPPSLLSTLDPTHLGLPEQLASVTVPIRLDTLSYLLHSALLGTYNLQQSLPPCSCTAQPSHIWPDTVRRPPRRSGQARGGWEVRRRPSRGWGRGRGRGRVWAQSQRGPERAEERERNMAGEPGAGPSTPPVTPPSQDGQKEAGGLSEDWEADY", "length": 185 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BLP0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLTNILYFQAGLGILANTFLLCFYTFTILCHRSKPMDLTSCQLTLAHILFLLAGGDNWLAVILESLNIENDFKCKAIFYTNRVMRGFSICITCLLSVFQAVTISPHTSLLAKFKHKLKTYIIYAVFYIWFYNFLVCSHLLVYVGGFNNVSETNQMRVTESCSLFLMNYIISGLIFTVTTFRDVFLVGVMLITNAYIVIILFRHQRHCKHLHSIRHLRVSPEKRATQTILLLMVFFVVMYWVEIIISSTSLLLWMYDPGFLTVQKLIVTVYPTITPLVQISSDKRVINVLKNLQSKCQQIF", "length": 302 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3ITL1-1", "protein_name": "Gap junction protein", "gene_name": "gjc4a.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSWDFLTHLLDEISNHSTFVGKIWLTLLIVFRIVLTVVGGETIYDDEQSEFVCNTLQPGCKNVCYDAFAPLSHVRFWVFQIIMISTPSVMYLGFAMHKIARMADNEYQPRKHKMLSTVHQRMNRDYDMVDEMTEEVPMIPEEIEPSEKDNKSAASTKTTAASDAAVKHDGRRRIKRDGLMKVYVLQLISRVAFEIAFLFGQCILYGFEVSPSYICTRSPCPHTVDCFVSRPTEKTIFLLIMYVVSVLCLALTVLEILHLGIGGLRDSFRSRANRRLPVHRPSTSTICHRLSSAPPGYQAVQKKYSSGKLKAEFLSDSGRESLADDNTTRDLDRLRRHLKIAQQHLDQAYHTEEVGASHNSGPDSKSIAAEQNRLNQAQGGFGSTEEKVFKEAHA", "length": 394 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3L8A5-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "FPSRQERTMRRENQSSISEFLLLGLPIPPEQQGVFFALFLGMYLTTMLGNLLIILLIRLDPRLHTPMYFFLSHLALTDISFSSVTVPKMLMNMQTQDQSIPYAGCVTQMYFFMFFACLDNFLLTSMAYDRYVAICHPLRYTSIMRGGLCTLLVTVSWILSCANALCHTLLLAQLSICAENTIPNFFCDLGALLKLSCSDTSFNDLAIFIAGVATIMLPLLCILVSYGHIGATILKIPSTKGICKALSTCGSHLSVVFLYYGTIIGLYLVPSSSTSSHKDIVASVMYTVVTPLLNPFIYTLRNRDMKGALEKLFHKAPVLS", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3L8Z8-1", "protein_name": "LRRC37A/B like protein 1 C-terminal domain-containing protein", "gene_name": "LOC100514982", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMTLELEKLILPSHMACCLCQFKSNIEVVCKTVKLHCDRCLKNSTRCDKETSLGDVEGSFMKVLQARKKNTSTELMIEPERPSSDKSGVSLSSFMNEQLDFSDESDVISALNYILPYFSEGNLEDVESTLLPFIQLLFSNVAEADIPPGHLKTHTGNPPVNPESGTSGYTNKLRQLRFLENLLDAEIQEKIDEVMKKEKTAMLIYSNILSPKLRRQILRKKLETARTQAESLEEIESVDKRPLKVNRVLKGPRGIKKRHFRAMRRQSIRRKETAQPFVETTTKGSKLGGPSARELEQLWVVQRPRKRVADSLQKEPSFGREHKAEVSSFLKQYSRGRPAASIHPKAPATVKKTSEDLSDTLFVLVDANARVKNRKASETISYPRKIDSFHPSHSPVLHRTPEPQNRQAFRDKGSSYRLLLALRPLSSAVRSLINSPSQEASSPSGELTLQEQPSPESFSPSEPSTEHIISEKDTPQVVFEELPTSGTTTLSGPIPGPTAQGTLPTEYSATTADNVMPTGQHTSAIQWEHHNVGTDVASTPTSFISPGVSSPGSQFEAQLNQQLQSLIPNNDVRRLISHVIRTLKMDCSEPQVQLACAKLISRTGLLMKLLSEQQEAKASKAEWDTDQWKTENYINENTEAQGEQKESSELTKDVPGYGYNNKLILAISVAVVLMLLIVILCLIEVYSRRRTLREGKVGRRRGFFGFLLRKRRSGESESEGFFWRRRPLWLRDTYRPLSATRKKNMAEKLHDKESSDEEEIFHKGAGEVSEAPADVILTIESDVEDLGEETDTAPEGPPE", "length": 799 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LBH4-1", "protein_name": "Large ribosomal subunit protein uL11", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPKFNPNEIKAMYLRCTSGEISAKSALAPKIGPLGLSPKEVGDDIAKAAGDWKGLRITVKPTIQNRQAQMEVVPSASALIIKAPKELPRDRKKQKNIKHSGNITFDEIVNIARQMRRCSLARELSGTIKEILGTAQSVGCNVNGRRPHDIIDDISSGAVECQAS", "length": 165 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LC12-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFGANLTIFHPTVFILLGMPGLEIYHTWLSIPFCLMSIVAVLGIGALILVVLSESTLHEPMHVFLSMLAGTDNLLSTTTVPKALAIFWFHAGEIAFDACITQMFFIHVAFVAELGILLAMAFDRYVAICALLRYTAVLTPSTIVKLTLAIWGWGIGTIFPIIFLLKRLPYCRTNIIPHSYCEHIGVARLACADITVNIWYGFSVPMASVLVDVAFIAVSYTLILQAVFRLPSQDAQHKALNTCGSHIGVILLFFIPSFFTFLTHRFGKNIPHHIHILLANLYVLIPPMLNPIIYGAKTKQIRDSLAHMLSRVGMS", "length": 315 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LEQ2-1", "protein_name": "All-trans retinoic acid induced differentiation factor", "gene_name": "ATRAID", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARPGFRSPSSLVPRAAALLLVLSVPRALALPEICIQCPGDVQNLSEVALYCKQTPELMLQGRCCLNGKGTILGLDLQNCSLKDPGPDFAQAHTAVIIDLQANPFEGDWANTFRGFTQLQTLILPQGVNCPGGINAWDVVTFYITNQTCQGQRTFATALGTQKRVLRMDLVLLMVLVSCSVFVLMASMATSVCARAHSHCSCSSVFWDPQHYPFPSCFGGLNAEKPRLHEPQRSSY", "length": 236 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "J3QM75-1", "protein_name": "Secretoglobin, family 2B, member 19", "gene_name": "Scgb2b19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLITGELSFQTTEACVPFFEGYASVVSGSRVWLYHELQSFDATAEEKVALEKIQGCYREERLRNILLEPKIMEAMVASPECRSYYSLNNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMG8-1", "protein_name": "T cell receptor alpha variable 13N-3", "gene_name": "Trav13n-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRLLCSLLGLLCTQVCWVKGQQVQQSPPASLVLQEGENAELQCTYSTTLNSMQWFYQRPGGRLVSLLYSPSWAEQRGGRLTSSAASNESRSSLHISSSQITDSGTYLCAME", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QML3-1", "protein_name": "BTB domain containing 35, family member 29", "gene_name": "Btbd35f29", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHQGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKKVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIIWDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDALTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMQ9-1", "protein_name": "Predicted gene, 20873", "gene_name": "Gm20873", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRESSSNTLRNIVGRRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPGLYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANLSVYFIKFHGDIHIYVYTMVPKILEVEKS", "length": 232 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMS5-1", "protein_name": "BTB domain containing 35, family member 2", "gene_name": "Btbd35f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEDIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKKVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMW5-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADIILKYSPDEARSLKAYGELPEHAKINEMDTFGAGDDDEIMFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMW9-1", "protein_name": "BTB domain containing 35, family member 6", "gene_name": "Btbd35f6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLQTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QN64-1", "protein_name": "BTB domain containing 35, family member 22", "gene_name": "Btbd35f22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDMKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYIDNISFLESEEGLIFQPVFKKLRFQHIIWDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QNQ5-1", "protein_name": "BTB domain containing 35, family member 24", "gene_name": "Btbd35f24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEGIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKDTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIIYDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP08-1", "protein_name": "Histone H2A", "gene_name": "H2al1k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKKMQRRRRQKRTRSQRGELPLSLVDRFLREEFHSSRLSSSALSFLTSVLEYLTSNILELAGEVAHTTGRKRIAPEDVRLVVQNNEQLRQLFKPGGTSVNEDDN", "length": 105 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP87-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLEAMCFDGVRRLCNIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNQDEARSLKAYGELPEHAKINETDTFGAGDDDEIVFDDIGDEDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP96-1", "protein_name": "PRAME like 3C", "gene_name": "Pramel3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPDISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSRMNHLKELSLSSFCLTDHLETVLRVLSADLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD", "length": 463 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QPI8-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLTKKVWINTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINEMDTFGAGDDDQIVFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QQ02-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLESMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINEMDTFGPGDDDEIVFDDIGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7GP63-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "K7N5V5-1", "protein_name": "Predicted gene 5862", "gene_name": "Gm5862", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLEENLIKKKLVILQQESKEVHADWATIHQSLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N660-1", "protein_name": "Predicted gene 10220", "gene_name": "Gm10220", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARKLGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPSWE", "length": 267 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6B6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r168", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSQNGAMKTTEEVALQIVLLCQFGIGTMANILLFVHNFSPLLTGCQLRPKEVICANMAVSSILILFMTVFPNNVFVAQRNLLNDLQCKLEYFVYMVARSTNLCSTCVLSTYQFVTLVPGNFSELMVRGRSPKVISYSCCSCWLFGILYNVYIPMKVSGPQNRHNKTSTKSKWVCFTSGFSVGIVFLSFAHDAIFISIMVWASVSMVRLLYRHYQRLQYIFPPHQGNRGYAEIRAAHSIVLLVVTFVSFYLLHCICFILHIVFVDSNLWLRHIGEVLTSSFPTISPLLLIFRDPSYPCSLIFNYKKPVI", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6B7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Gm10670", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVRGKSLKTTEEVALQIILLCQFGVGTMANDFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTVFPNNMMAFAPRNPPTELKCKLKFFSHLVTRSTNLCSTCVLSMHQFVTLVPISRGKLLLRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSKFFCSTSGFTVRIVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAESRATNTILMLVVTFVSFYLLNFICIIFHTFFIHYNLFIRLLGEILAAGFPTISPLLLIFRDPKNPCLELFHCFKPESLQNLKHRRQLH", "length": 321 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6G6-1", "protein_name": "Predicted gene 16440", "gene_name": "Gm16440", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLCQKENGDEGEIRTTEKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKITKQRSKINELEELKLDMRKISNDMEEMGGILELYIYEDLNYRMNTEFNIIKSQHEKTMLDMNEMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLSEKVRILLNENRKLLVEQAGTQLSHEEEKRFCEEASKNICASSAKEQQCVNSSRNRNMAQTTT", "length": 218 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6J5-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r127", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLTAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6P1-1", "protein_name": "Reproductive homeobox 2H", "gene_name": "Rhox2h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKRSINYLLDVGPEEDEENANGVKTLMVLLAGEGRNEGESGRGLPGSGVSAAEGYRAGELSAGGPAAPVAGLMDNSNQEDLSATGCAQEKETQPEEPVPDSMGDLENVKPMSGPWSTVNPVRVLVPKFRHLWRHNFNVLQLQELESIFQCNHYISTTEENRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6T9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r175", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLQNKSVKTTEEVALQVLLLCQVGFGTAVNIFLIVHNLSPILNGSQQRPIKVILANLAVGNTLILLFAFPNNMTLFVPKDPPTDLKCKLGYFIWLVARSTNMCSTCFLSTYQLVTLAPGTWGRVMLRGRAPKFVRYICYSCWLFSVLNNAHIPMKVNGPQKTHNDTNTKNKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSTNQKLRVHAETRASHTILLLVVTFVTCYLLDCICTVCNISFLDSRVWLRRVKQILDVSFPTFSPLLLIFRDPKDPCSLLFCC", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6U2-1", "protein_name": "Predicted gene 3542", "gene_name": "Gm3542", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSRLLRLCQKENGDEGETRPKKKEEGILSHEKGRRKSFWRRHRSARNTSTQNSNITNQISNINKVEELKLHIRKTSNERKEMCGILNVYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNEKVRILLNENRKLLVEQAGTQVSCEEERGSLRRPARTSVPQVQRNSSFPKCETVQQKLEHGTDHDMISLKEKCWWKRTGCAQEIHHCCLSSLITMAVMGCMLLLYFGFLGMNRP", "length": 270 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6W5-1", "protein_name": "Predicted gene 17019", "gene_name": "Gm17019", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRDTREGRKDADLPSERNEGRRRWTWRMWMALRQTSSPVPVISKKQFEKEEKKLIKEIQLTTEETNELRDRLIYVTEGSMNKRPYHRQNPLYEKLKLKEKEIMTFLHNLEMENMEAQENKQELKKETHFYRNLHSRLLMEENLIKKKSMTLQQESKEVQADWAIIHQRLVELNLSVKDEQENSNLETPEYQVSEAARELGLATAEEDSILQNELPGQEAPAEHHLQHPQSSSDESSSI", "length": 255 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6W9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r170", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLQNKSVKTTEEVALQVLLLCQVGVGTAVNIFLIVHNLSPNLNGSQQRPIKVILANLAVGNTLILLFAFPNNMTLFVPKDPPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQLVTLAPGTWGRVMLRGRAPKFVRYICYSCWLFSVLNNAHIPMKVSGPQKTHNDTNTKNKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHHRLQHIQSTNQKLRVHAESRASHTILMLVVTFVTCYHLDCICTFCNISFLDSQLWLRRVKQILDASFPTFSPLLLIFRDPKDPCSLLFCC", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6X3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r94", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPKFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVIFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6X7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r103", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIYQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHISIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVSLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQYRRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSISPLLLIFRGPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6Y3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r115", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPKFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSIILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFYIHSRLFIRLVSEVLAAVFPSICLHNGVLLSY", "length": 295 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6Z0-1", "protein_name": "Predicted gene 17026", "gene_name": "Gm17026", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "XRSSWVPKQACCPCSSGYFRERIEYTQTPDQGRRRPAAHHGGKGQETTGHGEGSAGAASPQAPTINDQEKRHERLEKLKRELQNIKNARDELQGILANYTNKDLNDRINFETFMLQMQHDQVMTDLKRMPQDISEALYKCKQLTKENQFYCFRNCHLLIESNLIQHKVRMLRKENRQLLREQIALEECNIETKILCKEGSQKIKDHYTKQQQI", "length": 213 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N701-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r159", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMSVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNTRGQAESKATRTILMLVFTFVSFYLLNFICIIFHTLLMHSHFFIRLVSEVLAAVFPSISPFLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N708-1", "protein_name": "Predicted gene 10128", "gene_name": "Gm10340", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNTSVI", "length": 205 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N731-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r57", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVLALNILLLCHVVVGTVGNILLFVHNFSPNLTDSRLRPIQVILINLAVANAFMLLFSTYSYDLIDFVPRKPPTDLKCKLAYFFHMVARGTIMCSTCVLSTYQFVTLVPGNWARVMFREISPKVVSYSCFSCWLFSVLNNAYIPMNVSGPQKSHNDSDSKDNWICSISGVSVDMNFLRFSHDIIFLGIMAWTSVSMVIHLNRHHQRMNHIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCIIILFHITFVESRLSLRHVTKLLSLSFPTISPLLLIFREPRGHCSLLFSVGLEIHVTGGVITEEQ", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N744-1", "protein_name": "Predicted gene 8104", "gene_name": "Gm8104", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGNQGETRPRQKESAIPSCKNRRMKSFWGRHMSAGKTSSQNCNITNHMKNMNKLDDMKFYIRKINAERLELFRILDIDMNTDLNYRMNIDFTIIKSQHEKTMLDMEKMTQSISDTIEKYKEFIEDKDSYSFTHTYLLKECNQLKEKVRMLLNENRKLLVEQADQETSYGEEKRFCDETSKNIHPKC", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N751-1", "protein_name": "Predicted gene 3696", "gene_name": "Gm3696", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPKKKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPQEHLCPKCQGTAV", "length": 203 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N757-1", "protein_name": "Predicted gene 3667", "gene_name": "Gm3667", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNEKVRILLNENRRLLVEQAGHKCPVGKKRGSLRKPARTSVSQVPRNSSVK", "length": 205 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7F4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r260", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGNSLKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLESFSHLVVRSTNLCSTCVLSVHQFVTLVPLNRGKGKLVLRASVTNMASYSSCSCWFFSVLSNIHIPIKFSGPQITDNNTDSKRKLFCSTSGFSVGIVFLQFAYDATFMSIMVWTSVSMVLLLRRHRQRMQHILTPNQNPRGQAESKATHTILMLVFTFVSFYLLNCICIIVHALFMHSHFFVRLVSEILTAIFPSISPLLLIFRDPKDPCSVLFNC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7G0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r163", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVMTGSKKRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLKFSHDATFMTIMVWTSVSMVLLLHRHHQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPNICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7G4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r242", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPVSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSLLFKC", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7H2-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r256", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILGHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSLLVARSTNLCSTCVLSIHQFFTLFPVSRGKGKLILRASVQNLASYSFYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDDTFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAESRATHTILMLVFTFVSFYLLNCICIIFHAFSIHSCLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9JA28-1", "protein_name": "Interferon lambda receptor 1", "gene_name": "IFNLR1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAWRIRVLATLCFLWQPRVHGQLPPPQNVTLLSKDFDMILTWTPGEGSPPDVLYTVRYESKTRMDKWIKVPHCRNIHSVSCNLTCVIPNFFIKFRAQVKATSGRFHSPWVKSQFKEYHLDVELAPPLLNVNVKENVIHVNATFPMAICVESLPWMYDFNLWEAGSEDKKQYKSIFRKKAVTIDTTALRGNYCFNARSSIQSIDFKHSKFSQPVCMQLNYEGEWKFPFSATIPVFVLLILLTSASIIWLLKQDAKHKKMPQTLDLSNCKIAGPTFCCELRENEFLTDCLICTDKPMSQGKKNKTLAQNNQMWMASFLPSSSSEEEEEEEEEDSSSFIPYTEMLQFPRKHFNFQTPRTADAETILDSTSGVLSVVGGSTLDLSALGFSFFPIRKNEMDTSGSQGNEKASHSHSSSLGRISLTDVRFPGPREHGQHGTDSNDCLEVSLLHTLMNSSCTRLPADEHCLYKKDHDFTICYQKPTLDQPVQVSENPLLNEDPSMEKFIYLQTLQVAEDEGFASDCDSGNFTEGTPPASTVLSDELRISDMEKRYDKKFKFKGYQHSHYMRRS", "length": 567 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "L7MU37-1", "protein_name": "Reproductive homeobox 3H", "gene_name": "Rhox3h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSISNWIHSNVEPAGRNLFQVNGHRSALLPELPQDYHRASRSVNGCETKMDSTQGTKVLPAEESRNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEAPRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREQYRWYKRL", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU51-1", "protein_name": "Olfactory receptor", "gene_name": "Or4a76", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQSNNVTEFVLLGFTQDPAGQKALSVMFSLIYIVTMVGNLLIVGTVIASPSLGSPMYFFLASLSLMDAIYSTAITPKLIVDLLCEKKTISFRACISQLFIDHLFGGVDIVILLAMAYDRYVAICKPLHYLIIMNRRVCILFLVMAWAGGLAHALFQVLAVYNFPFCGPNIIDHFGCDIYPLLLLACTDTYFLGLSIIGNNGAMCIVIFTLLLLSYGIILRFLKNHSQEGRRKALSTCGSHITVVFLFFVPCIFMYVRPVSSFPIDKFITVIYTIVTPMLNPLIYTLRNSEMKNSMEKLLQKTLSPSRIRLSSCCLCY", "length": 318 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU81-1", "protein_name": "BTB domain containing 35, family member 17", "gene_name": "Btbd35f17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANTWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU83-1", "protein_name": "BTB domain containing 35, family member 18", "gene_name": "Btbd35f18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDQVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MUB9-1", "protein_name": "Reproductive homeobox 2G", "gene_name": "Rhox2g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSINYKLDVGPEEDEENANGIKTLMVLLAGEGRNEGESGRGLPGSGVSAAEGYRAGELSAGGLAAPVADLMDNNNQEDLGATGCAQEKEKQPEEPVPDSMGDLENVKPMSGPWSTVNPVRVLVPEFLHGWQQSFNVLQLQELESIFQCNHYISTTEAKCLARSMGVSKATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1X6-1", "protein_name": "F-box/WD repeat-containing protein 15", "gene_name": "Fbxw15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIHLPCLPMMKILSYLDAYSLLQAAQVNKDWNELASSDVLWRKLCQKRWLYCDMDTLQLQGKETWKQFFIDRIWQERAKFRAKAKDFTYKEIPLMCGLFGYACYISGCGLTRKGQDKSVVCMVNSKNTISTWDVHKSVITWKSPEQPASIKLLTTLPEMHIAVTVDIQSTIKLWDCHNREALATNNLKSPCKSLKAVFTKDGPIVLIGDTLGNIHIFRIPDLYLISTVNVLPYGFDGIYCSPQKKWVLLSKKHPHILPKVFYMSSFLRTSEFSAPVSTVLKLSLYERVFWTPRREDRITLMSRSGFPQVKMFETYDIKLEEFGNKRIVKGKLIASFELQCHKVNPQRFGVSDKNVIVCSTESSLLLFDINGLRLKTFQYCPEMIVKLSVDPLHVIVICNTGSMDVYAWEERSLLLRKCYRLHIERPLPLYGFIYKAACDDVSIIQLITDELSLSSLTSYALNICS", "length": 466 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1X9-1", "protein_name": "Demilune cell and parotid protein 1", "gene_name": "Dcpp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQLEAMLALLILAFLGTPTVLTQDYHGPEVGKHSCTSAPEGKNITSIRVFLKGRLIVGIQLNYDDNKDGQVYGSTAGKEMVARLSKEEHIIAAQGTYTPSALTQIIFTTNQPRQLMVGYYVGNSEYSSFPNDPSHVLKGACVSWRAGGIKSILFLWGSENSSCVKYGHSG", "length": 171 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1Y3-1", "protein_name": "PRAME like 51", "gene_name": "Pramel51", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIHSKERKYRLGLLEPGVTAFPCPNMVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGHIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSPGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFTLGDSEKLDEETIFSLISQLPTLHCLQKLYINDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPFCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELVSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPIECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVEL", "length": 520 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1Y5-1", "protein_name": "Olfactory receptor", "gene_name": "Or11g25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLSSPSNSSTITGFILLGFAYPREGQILLFVIFFIVYILILMGNASIICAVYCDQRLHTPMYLLLANFSFMEIGYVTSTVPNMLANFLSDTKVISFSGCFLQFYFFFSFGSTECFFLAVMAFDRYLAICRPLHYSSLMTGRLRNTLVTSCWVLGFLWFPVPIIIISQMSFCGSRIIDHFLCDPGPLLALACSRVPLIEVFWSIIMSMLLVIPFLFIMGTYILVLRAVFRLPSREGQKKAFSTCGSHLTVVSLFYCSVMIMYLSPTSEHEAGMQKLVTLFYSVGTPLLNPMIYSLRNKDMKNALQKILRT", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N227-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r125", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSMKTTEEVALQIILLCQFGIGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFARKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNFANYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N255-1", "protein_name": "Predicted gene 3099", "gene_name": "Gm3099", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSRLLRLCLKGNGDEGETRPKKKEEGILSHEKGRRKLFWRRHRSARNTSTQNSNITNQISNINEVEELKLHIRKISNERKEMCEILNVYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMTQFIIGSMQYSMELIEDNYSYSIKEDHLLRECTQLNKKVRILLNENRKLLVEQAGTQVSCGEEKRFCEEASKNICASSAKEQQLP", "length": 205 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N259-1", "protein_name": "Demilune cell and parotid protein 3", "gene_name": "Dcpp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQLEAMLALLILAFLGTPTVLTQDYHGPEVGKHSCTSTPEEKNITSIRVFLQARSIVGIQFNYDDKDGQVYGSTAGKEMVARLSKEEHITGVEGSYSPSALTQIVFTTTQPRQLMVGYHVGIYQYSSYPDDPSFVLKGACVSWRAGGIKSILFLWGSENSSCVKYGHSG", "length": 170 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N270-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r123", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILIHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVPVNRGKGKLILRASIPNLWNYSCYNCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFAYDATFMIIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHAFSIHSHLFIRLVSVVLAAVFPSICPLLLIFRDPKDPCSVIFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N273-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r118", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSVHQFVTLFPVSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSLLFKC", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N275-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r169", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKSVKTTVEVALQILLLCQVGVGTVVNIFLFVHNLSPFLNGSQQRPIKVILANLALGNTLILLFAFPNNIRVFIPREFPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQLVTLAPGTWGRVMLHGRAPKFVRYTCYSCWLFSVLNNAHIPMKVSGPQKTHNDTNTKSKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSPNQKLRFHAETRAAHTILMLVVTFVTCYLLDCICTSLHISFVDSRVWLRRVKEILAVSFPTFSPLLLIFRDPKDPCSLPFSC", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N288-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r151", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQILLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIYQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHISIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVSLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQYRRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSISPLLLIFRGPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2A6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r116", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFFHNFSPVLTGSKQRPRQVFLSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2B4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKKRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMTIMVWTSVSMVLLLHRHHQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLGAVFPNICPLLLIFRDPKDPFSVLFKC", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2C2-1", "protein_name": "Predicted gene 2974", "gene_name": "Gm2974", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKERRKWFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNSSVI", "length": 205 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N474-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1E", "gene_name": "Speer1e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "ARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKESSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMSITQNQKNKEVEIDWALIEKYLVDVNLNGRTGADQQP", "length": 154 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0QWR4-1", "protein_name": "Aly/REF export factor family member 14", "gene_name": "Alyreffm17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADKMDMSLEDIIKLTKIQQRRHDRPDSRVNRGTGSKRYRPAFTHGGRNRLAPYCRPKQLPDKWQHDLFIGGFRGQNHVDTGGKLFLSNLHFGVSDADIQLLFAEFGTLKKSAVHYDRCGRSLGTAQVHFERKADALKAMREYNGAPLDGRPMNIQLATSQIDRQGRPAQSKNRGGMTRNPGSGVLSGGGTKKWTLGGSQGRGRGTIRNSKLQQQQQQQKQKQQQQQQKQQQKQQQKQQQQLSAEELDAQLDAYQEMMDTS", "length": 261 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0R3T3-1", "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "ENSRNOG00000067174", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRFLVLCLILSLGDYGAFPLIQSRIHRGCKGERHSQPWQVAMYHYDKAVGWGWHPSPTTMSTSPSHNKVRLGQHSLDADGDTGQDVPVRHSIPHPLYNRSLQMPTFLSPDADNSHNLMLRQLREPANTTEAVRVTEEPTEEAKLGSRCLASGWGSTRPDKCMPGMLQCVDLTLMSSDVCTYAYSQRVTESMLCAGHQEGSRDTCMGDSGTTLICDRMLQGITSWGGNPCA", "length": 230 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R777-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Smokwl5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASKSKEKTLGSHYKILSYLGQGSFGTVNLAWHLKTQALVAIKMLEISKETISSILSERAILETLHHPNIIRLFQVLITSSHVNFVLEYAPGGSLFELIKEGGPLQEEVAKKIFGQTVSAVKYCHNLDIVHRDIKPQNILTDAEGNGKLTDFGLATKFRPGTLLKELCGTKEFYAPELVLREPYNGKKTDVWSLGVLLYFISTGYCPFRGVTTKDMEKKIATGTYTIPTYFSGQLENLIHQILTVSPEMRPSIEDIEKHPWVRKCEVNIPTITCPDYKIVEMLCGMGYNANKILESLQKKKYDEPMAAYLILKDKVRQEIEHGTTTSDMPVDQGPLPPQSPAHHSVSGLPLKRRASEPNFGLLHIWPPGEQVARHNVARSVSMPPIALYGTKKQNSTSTSALHSRPVASPCVCNTILEIEIPLPTKQDFDMKTSSPPQRIGYFQRLCQRIRDCLSRLCCFLWAPKVHSPRKWLP", "length": 474 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R9M1-1", "protein_name": "Olfactory receptor family 52 subfamily N member 1B", "gene_name": "Or52n1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLLNVSSLTPASLILNGIPGLEEVNLCIFFPLFTMYSIALTGNFGLIYLIYSEEVLHRPMYIFLALLSFTDVLMCTSTIPNTLFISWFNFKKIDFKACLAQMFFVHTFTGMESGVLVLMVLDLYIAMCYPLRYATILTNVVIAKAGMLTFLRGVALVIPFIFLTKRFPYCKGNVIPHTYCDHISVAKISCGNVQINAIYGLMVVLLIGDFDIPCITVSYTMILWAAVSLSSADARQKAFSTCTAHICAIVITYVPAFFTFFTHRFGWHTIPSHIHIIMANLYLLMPPTMNPIVYGVKTKQIQKRVIRFFFKGRENSSHKF", "length": 321 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R9X6-1", "protein_name": "Paired immunoglobin-like type 2 receptor beta 1 like 2", "gene_name": "Pilrb2l4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLVSLPEQNLAMAWILLLLLLAACLHTGNSAGYQKTQDYGVNQPEQLTGIQGGSIEIPFSFYFPWELAKDPQMSIAWRWKVFFGEVIYNSTLLFLHEHFKGRLIMNWTQGQTSGVLRILNLKANDQSTYFSRIFLQATEGMKLWQSRAGTKLIIHALSTTMASPSIIPSAVPTAGLENTRGQRNPSLLNLGAMVGMVMAKVVVIIPLYGWVIFLWWKQRLPTARISHQVSLHHTPCIPQSSMSSLWESELVAAGFSCESHSWITPTSAMGARIPSPWNQGPPVCLWA", "length": 289 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RAD6-1", "protein_name": "Olfactory receptor", "gene_name": "Or1f19f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSTNQSSVSEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILVISTDSHLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILSSQAISFSGCLTQLYFLCVSVNMDNFLLAVMAYDRFVAICHPLYYTTKMTHQLCVLMVSGSWVTASLNALLHTLLMARLSFCGDNIIHHFFCDVTPLLKLSCTATNLNELMILTEGAVIMVTPFVCILISYIYITNAVLRVSSFRGGWKAFSTCGSHLAVVCLFYGTIIAVYFNPVSSHSSEKDTAATVLYTVVTPMLNPFIYSLRNNDLKGALRKVVHRKI", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RBH5-1", "protein_name": "Surfactant associated 2", "gene_name": "Sfta2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPSMCLFLLLTLLCSSLAGPTKVTLQVKLTEASQAKTSQDSGFLDMLQKICLLLHLSPGTNVTLHHKGPPHHLTCRA", "length": 78 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCJ6-1", "protein_name": "EF-hand domain-containing protein", "gene_name": "AABR07013776.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADQLTEEQIAEFKEAFPLFDRDGDQTVTTKELGMVMGSLGQNPTEAELQDMISEVDADGNGTINFPEFLTMMARKMKGTDVEEEIREAFRVFDKDGYTSAAEFRHVMTTLGEKLTDEEVDGMIREADMDGDGQVIYEEFVQMVTAK", "length": 147 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCP1-1", "protein_name": "Leukocyte immunoglobulin like receptor B3", "gene_name": "Lilrb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSTLTALAYLGLILGSENPVLSGAFTKPTIKMVPSNVVTTGKQVTIFCEGSSHAKEYRLHKEGSPDYLTPTTFLETENKAKFSISPIQWNNAGQYWCSYRSLTNKLRQSDIMELVVTGVILGEVTLSALPSYVVTSGRNVTLQCASQVVYDRFILMKEDEKFSTAMPSWKIYPVLWGAIFTLGPVTSNQRWRFTCYGYYLSSSLIWSKPSNHLELLVSGTLHKPILWAHPGSMVTSGSPVTIWCEGDQETQTYVLYRQGSLESWNRQTQKDYNNKAEFTIPSVTYLNAGHYFCYSYTSAGWSEHSDTLELVVTGVYKKPIFLALKNPIVNLGVTVTISCTSNQSFNCFLLMDDDQKIYRFFDLQYSYSGESLARFQVGPITSRQRWRFRCYGYYTDNPQVWSEASDPLDFLVSGNLQKPTLWAEPGSVIESGNSVTIWCEGTMETQIYFLYKEGSPSSWLRQTPKEPGNKAMFFIAFMEKHNAGQYRCYCYNFGGWSQHSDTLELVMTGVHHGKPTLSAFPSPMVTSGGNVTLYCASSTIYDWYIVTGQDLKFSRFQRAQFIPTEMSQALFSEISVASRKKGPFRCYGFNESTPHLWSEASNPLEIHVSGVSRKPSLLNQQGPVLAPGENLTLRCSSELSYDRFSLSKEGRSDLPQLSVSQSQTGEYYANFFLYSVDFSIAGQYRCYGASRFSSEWSAPSVPQDILVTGHPPITPSLSVNPGTIVSSGENVTLLCQSSIPMDTFFLFKKGDAYPYMHQRLKFQGPQCKAEFSLSAVTPNIGGIFTCFGSQSSSPYLLSHPSVPVEIKVSGLAKYQKSLIWVSVVFFLLFFVLTLFFFLRLWHQNKHRKGVQTKIDLQHPEGAVEPKSIVGHLQKSSRPAPAIQEEILCEKRWPGREITEVSASDATVKVTRSADNVELGILSQHQDDPSIHLYAQVKPARLRRAQTTSSSLFPKELQHSKHRQKNRDQVIDQQADTSQDSHAVIYAQLHIMTPRQGRQTSLFPGRIC", "length": 1008 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCQ2-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100361204", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFGLAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIPLLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLLSLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPVTKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCANPIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQSSIP", "length": 328 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCW7-1", "protein_name": "Uncharacterized protein", "gene_name": "Pilrb1l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLVSLPEQNLAMAQLLLLLLSAACLHTGNSAGYPKKNVFSVDQPAVLSGVQGGSIEISFSFYFPWELAKVPQMSIAWRWKNYHGEYIYNSTQPFIHEHFKGRLIVNWSQGQTSGVLRILNLKENDKATYFSRVFLPTTEGMKSWQSVAGTQLIIIHAPSTTVVSPSIIPSVVPIAGLEDTRGKRTPSLLNLGAMVRMVVSKVVVIIALYGWVIFLWWKQRSAWSLLSFLTTWKSEEQMQMNTAPAPKEFK", "length": 252 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCY4-1", "protein_name": "Retinoic acid early-inducible protein 1 domain-containing protein", "gene_name": "AABR07000137.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSAPLGSLGRKSKNQSLGLDMLGTVLSTDSLSCTFTVKYRSSPGQCSVNGKPLLLFNDERQNSPVGKPEKKGNATKVCAELNQSLKDIFQKMMNLESWLFESKGNHTLQVTVQSQYNQGIFMDGCWVFTIDRQYPFYFYPKIMTWRESHPDASRTVSQWQNNRQVAQSLRTCSMGDFSQCLRKLLTDSREVPRSTITTLDPTQPSSAIQIPPTVDSASSVFTTWSQYIFVLILCLAILIINALIP", "length": 246 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RD07-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000064269", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRMMAMQMMTNSISDAMERYKELIQVNSSYNIRQSQLLREQAQLKNNIQILLNEKRELLVEETELPASSVEAKRLCEEAGMNICDPRAKQQQV", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RDP5-1", "protein_name": "Zinc finger protein 353", "gene_name": "Zfp353", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVAETPGASQTVPCNTQPSPVESSQLVSGQSSEMPTWKKTVMASACCNPQETACTQNSTAHPGKASDFYFGEPSETASFIQQVVSAEQKSSPAGSCLMNLSSTTKSCLSHPLKTEVLDTRKTLCNEGHWGRTLNSDKTLLIQITTMYESQWRTLGNHPVAPSGYHEGQAPNMDHLVDSVSNQTFIGDLEMEPSCNHVLYTDQFITSFSEQNPFGDQQRSPVADNRFYADQKILPNGYQTFYEPQMSTNYQITCVCGQNVCRCQEILLSGEHLLSEYQTSGYRYDQDLIVNLQVTSPIGGEPLHDSQIPNSNFDTTSCGTKRTTSSEEDNLAWHPETSLSSEETFLDQMRTSVDQNVYPSHNGTLKIEESLEPQVTSLSNQAPYVGESSDTSNSPLIQIQPQEISSASGLDQGQHPEIKLDLKTQSPVSLKNPHNSKRYCCTYQGCKKSYKKSQHLKDHMKKHTGVKPYMCNKPGCDWKFFRLVDLNRHKQKHSGERPYPCPMCNKNYSRFYYLKQHLRSHIQASPTTAT", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9MSI7-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG42818", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFIHQREQLPFKHNEQDPNYLAPVIQKRKPMDKDPRNPLKRLKFLQEFPTQSSKGDLDDLKYPTQLEGRHDSPKYDKTFHTEIHANNETDSQELENIILEKNLQDSKTEFQENRASQPKNMHSFQIPEAIESHFNNKELQNENDLHKGLKQQYRSGSEQDKSGPENVREIASKLILQWAENQRSLLDSFVKAITDVLKVHDSKLNMKINISPRDIMILKDMLKQLLESIMQLREGSTSTRARIVLNKWIETQKSLIDSFSQAIQNTNQNVDNIANVYEVMENLNKNLRELVILLSDKESFPTTESSSSQQTTSIYATTTFYLTSSTFGSTHPIVDENINRVNIMGNLIKGLRNIMVQMDETNKTSSSTSYTTTESTYIQPSTSTYLNAEVTTSHPTTSTYEVTNIITDESKIKDMFNLIKGIEDLISQYNGKHKFTSTTSLTGKSNSREPTMTTYSSAGGITSHSFTTTSPKTVTTSSSHSTTESSPSHPTTSNYEVTVFDQDSHKFKVMKNLIKELKGLIEHFSDTKNITSTTYSTGDSKSFQPTATTPDSTDRSSSQPITFPESTTSTTNLQSTITNHLSTESTSSQLNTTLSITGTTTPNLTTSTHDFKDQINDDDSKSLKHLIKILSDLVYSLNDKNNIKSTSQLTTESTFNSSINITNSTTVASSTFSTTESMAIHSTPYLSTREITVFQFNDVENINPIISNNSTTVTTNIHSSTYTTSTTDNTTSYPNLSTTESSPTFDSTISHSNTSSQTRSLGSYKDKIKNIVELLKKLRKIQKTLADKSKGQLSPMLISRIKAVLKQIVAGNIDSVNGDSTELEILLSTTVNPNEDTTDLTMEKLLKLFDDFERMYNVLLDDSIQSTTQSTTQNNTIFSTTYSTIFSTTQSISTTSPTQYALTSSTPNTSTTSHSSTPSSINNLRSDESNNHQPIVDAIQQLKMALYHDFYAFKKSQEERMEKILQLLNGKPIDRRTKTIAKPRTIRKKVSREIQKRNSDVKEDKIHHYKADKFIKNPKNGNQDSHIPKPILNSARSKIKDVPLKLSAIKVNGGLKHLPSKRKANEEVSAMHEIFPEPVSILPHK", "length": 1085 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O08640-1", "protein_name": "Keratin-associated protein 14", "gene_name": "Krtap14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCNSCSGTFSQSFGGQLQYPISSCGSSYPNNVFYSTDLQTPITHQLGSSLHSGCQETFCEPTNCQTAYVVSRPCQRPFYSQRIRGPCRPCQSTFSGSLGFGSRGFQSFGCGYPSQGFGSHGFQSVGCGTPTFSSLNCGSSFYRPTCFSTKSCQSVSYQPTCGTGFF", "length": 167 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O21032-1", "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "mrpl16", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKIPNRQKFTKNHKRNLITKETRKTGLVLGNYGIKATETGYLKMKQMERIKGDLVKKLKDNMDIYFNFYPLFGLTNKGTARMGAGKGEVSEWYVLVKKGSIVVEFIKSRMTAGAMQKVIRYSANKWPIKVRMTQIKQGLYEKKI", "length": 144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O21042-1", "protein_name": "Cytochrome c oxidase subunit 1+2", "gene_name": "2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKILEIYDKQIAEKEGNIFIFISKWIISVDHKNIGTMYTNFSILAGIVGTLLSLVIRMELSTGNMLDGDGQQYNVIVTAHGLIMIFFVVMPAMLGGFANWFIPIMVGSPDVAFPRLNNISLWLIIVSFFLLLTSSCVGIGVGTGWTVYPPLSTMEYHPGHAVDVGILSLHIAGASSLLGAINFLTTVFNMKIAGLSWSKVSLFVWSILITAVLLVLSLPVLAGGLTMLITDRNFETTFFDPIGGGDPILYQHLFWFFGHPEVYILILPGFGLVSIILSKYSNKGIFGVKGMISAMSAIGFLGFLVWAHHMYTVGLDVDTRAYFTAATMIIAIPTGIKIFSWLATLWGGVIKITTPMLFVIGFLVLFTIGGLTGVVLANGGLDISLHDTYYVVAHFHYVLSMGAIFAIFAGYYYYYSIMNSTRLFGVVRYNEQLGRIHFWTMFIGVNVTFFPMHFLGLAGMPRRIGDYPDAYIGWNLIASYGSLITAFGLLFFVVNIFTPYIRRSVNIKNGAIILMGLDFARDWQIGFQDPATPIMEGIIDLHNYIFFYLIVVAVFIGWVMGRILWRFSYKWSYPTIGDIEIFKNFTAYNQIIHGTVIEIVWTLIPTVILYLIAIPSFTLLYAMDEIINPTVTIKIIGHQWYWSYEYGDNASNLIEFDSYMVYERDLAEGQLRLLEVDNAMVVPVKTHIRLIITSGDVLHSWAIPSFGIKVDAVPGRLNQIGLYVKREGTFYGQCSELCGVDHGFMPIKVQAVKLGEYFSKLNEK", "length": 764 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O21049-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "cox3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKGFFENLFRQNVRSVINTGKKVGARAAAREIINQEWGYPLANHEVLFLTNVYQPKHMKRHPFHIVRGTVAPLAVTLPLGFFVLNYFGVISSKLGLLIALSSFIGGLVIWTISIIFDSLYDQQHTYEVKRGLVMGMMMFIISEVMFFFSFFWSYFYISLSPNIAIGCVWPPYGLTVYSYMGLPLLNTVLLLLSGAILTDGYTILTEQKAVHEKNEKVLAVEEAFKNLMNLYKTKNSINTLTFVDERRDKFFGKESRQEDKIAEQKLIAISAGVKELRDLDWDLYFFENPENIEPNYKEPTNLSVIEYALITIYLKKRNKVIKTRLYFTLLCAVVFLACQGYEYFFAPFSMNDGIYGSLFFLLTGFHGFHVLVGSILIGIITIRFIVGNFNLLNVGTNFQIYKNKSTGFACTLFYWHFVDIVWIFLYIVIYWWGSR", "length": 435 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O23373-1", "protein_name": "Formin-like protein 3", "gene_name": "FH3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGRLRLAFLAISLVVFVCVSEEIFSRGGLNLLRFSVYGEDVAEQTWIHQNPRRKLISYPKKFSVSAPNLAFGPAPSFAPGPGPSFAPGPAPNPRSYDWLAPASSPNEPPAETPDESSPSPSEETPSVVAPSQSVPGPPRPPPQREKKDDILMKLIIAVASTAVLTFVFVALMFLCCFKRNCNNAVGSRDGPRDEGPLLRLSTGSTENSPTVASTSRKMFSVASSKKRSFLSRVSLKRNGHEFSTAESSSAAGLPPLKLPPGRSAPPPPPAAAPPPQPPPPPPPKPQPPPPPKIARPPPAPPKGAAPKRQGNTSSGDASDVDSETGAPKTKLKPFFWDKMANPDQKMVWHEISAGSFQFNEEAMESLFGYNDGNKNKNGQKSTDSSLRESPLQYIQIIDTRKAQNLSILLRALNVTTEEVVDAIKEGNELPVELLQTLLKMAPTSEEELKLRLYSGDLHLLGPAERFLKILVDIPFAFKRIESLLFMISLQEEVSGLKEALGTLEVACKKLRNSRLFLKLLEAVLKTGNRMNVGTFRGDAQAFKLDTLLKLSDVKGTDGKTTLLHFVVLEIIRSEGVRALRLQSRSFSSVKTDDSNADSSPQSVERYRSTGLQVVTGLTTELEDVKRAAIIDADGLAATLANISGSLTNAREFLKTMDEESDFERALAGFIERADADFKWLKEEEERIMVLVKSSADYFHGKSAKNEGLRLFAIVRDFLIMLEKVCREVKETTKTTNHSGKKESEMTTSDSNQPSPDFRQRLFPAIAERRMDSSDDSDDEEDSSPS", "length": 785 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O35698-1", "protein_name": "RNA-binding motif protein, Y chromosome", "gene_name": "Rbmy", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETNQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRLADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDDPPSKRSATSAQTRSNTGLRGREPHRREISRNMPRGEPASSRRDEYPLPRDYGQSSNDRKYESTSRGYCDYGNYHSREESASKVFSDHAGYLGGRDRDFSEYLSGNSYRDTYRSYGRFHEAPSARGGNNRYDDYSNSQDGYGGRGEPYISNRSNIYSSDYERSGRQEVLPPPIDREYFDREGRQERGHSPKDGLYSASRESYSSNTKIWGIPWRSWRKQI", "length": 380 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O60309-1", "protein_name": "Leucine-rich repeat-containing protein 37A3", "gene_name": "LRRC37A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSAQCPALACVMSPLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPEPWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGELPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQLPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLIVPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIIEPEEPSDSSGINLSGFGSEQLDTNDESDVTSTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGKNRQRLNRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENTAEEKRLGSPAPRELKQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNMKTSKPIVHSRKKYRFHKTRSRMTHRTPKVKKSPKVRKKSYLSRLMLSNRLPFSAAKSLINSPSQGAFSSLRDLSPQENPFLEVSAPSEHFIENNNTKDTTARNAFEENVFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWKTENYINESTEAQSEQKEKSLEFTKELPGYGYTKKLILALIVTGILTILIILLCLIEICCHRRSLQEDEEGFSRDSEAPTEEESEALP", "length": 1634 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O80489-1", "protein_name": "small monomeric GTPase", "gene_name": "SARA1A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MFLFDWFYGILASLGLCKKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKINFKAFDLGGHQIARRVWKDCYAKVDAVVYLVDAYDRDRFVESKRELDALLSDEALANVPCLILGNKIDIPYASSEDELRYYLGLTNFTTGKGIVNLEDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIK", "length": 193 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O80614-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSDMRDERFFYHRYLSVTNRTTPTTATNLPTSTSNMRSTSLMTPRVAHTSMSSGGDFPDDRFFHARHQSATDRAASNRSRAIMPISTTNVPSSTSNSPRVLQTSMSRRGTSPMSSSTRRSVQASMSARETVPSSTSTRSMQTSTSTPEIMPTSSRNVITSSEEVANTFTQTSYIQFGSLWETNTTPSTRSWPTVPSSNSPRVLQTSMSRRGTSPMSSSTRRNVQSSMSGRETVSSSTSTSSMQTSMSTPEIMPTSSRNVITRSEEVANTFSTQTPYIQFGRLWETNTTSSTRSRTTVPTSTTNVPSSNSSRVLQTSMSTRGTFPMSSSTRMSVQASMLAPGTVSSSMSTVEIMPTSARNMITMSEEVANSFTQTSYIQFGSLWETFKTVTKLSRVAMVENGECVICLEEWRKETYVTSSTSNMRTSSLMTLTRFIDEQISLRATVSSTRTTARLLTNESPATIRAVAMLPRVAMVEKGECVICFEEWSKSDMETELPCKHKYHLECVEKWLKIHTSCPQCRYKLSCVYKSFLML", "length": 535 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O81153-1", "protein_name": "Proteasome subunit beta type-3-B", "gene_name": "PBC2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSIFEYNGSAVVAMVGKNCFAIASDRRLGVQLQTIATDFQRISKIHDHLFIGLSGLATDVQTLYQRLVFRHKLYQLREERDMKPETFASLVSAILYEKRFGPFLCQPVIAGLGDDNKPFICTMDSIGAKELAKDFVVSGTASESLYGACEAMFKPDMEAEELFETISQALLSSVDRDCLSGWGGHVYVVTPKEVKERILKGRMD", "length": 204 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P00757-1", "protein_name": "Kallikrein 1-related peptidase-like b4", "gene_name": "Klk1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQCGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGILQGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP", "length": 256 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P01241-1", "protein_name": "Somatotropin", "gene_name": "GH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF", "length": 217 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P02762-1", "protein_name": "Major urinary protein 6", "gene_name": "Mup6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04071-1", "protein_name": "Kallikrein 1-related peptidase b16", "gene_name": "Klk1b16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWQVAVYYHKEHICGGVLLDRNWVLTAAHCYVDECEVWLGKNQLFQEEPSAQNRLVSKSFPHPGFNMTLLTFEKLPPGADFSNDLMLLRLSKPADITDVVKPIDLPTKEPKLDSTCLVSGWGSITPTKWQKPDDLQCMFTKLLPNENCAKAYLLKVTDVMLCTIEMGEDKGPCVGDSGGPLICDGVLQGTVSIGPDPCGIPGVSAIYTNLVKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04644-1", "protein_name": "Small ribosomal subunit protein eS17", "gene_name": "Rps17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKNLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P05817-1", "protein_name": "Prestalk D11 protein", "gene_name": "ampA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLNKLILLLILSSCLVLSVKSEVNVDCSLVRCAQPICKPHYRLNMTDSCCGRCEPCTDVACTLQVKYCQDGEVPTGCCPCTLPPTKPDCSLVKCARPVCKPYYRLNMTDSCCGRCEPCTGVACTLQIKYCKDGEVPTGCCPCTPQPTKKPDCSKVPCPKILKYCQEGELPTGCCPCTPQPTKKPDCSRVPCPKILKYCKEGELPTGCCPCTPQPTKKPDCSDVMCTMDIRYCKNGELPTGCCPCTPQETKVPDCSKAMCTMDIKYCKPGEKPFGCCPCRENLTQ", "length": 284 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P06325-1", "protein_name": "T-cell receptor gamma chain V region 5/10-13", "gene_name": "Tcrg-V1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLRWPTFCCLWVFGLGQLEQTELSVTRATDESAQISCIVSLPYFSNTAIHWYRQKAKKFEYLIYVSTNYNQRPLGGKNKKIEASKDFQTSTSTLKINYLKKEDEATYYCAVCRSGTSWVKIFAKGTKLVVIPP", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06349-1", "protein_name": "Histone H1t", "gene_name": "H1-6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSETAPAASSTLVPAPVEKPATKRRGKKPGMATARKPRGFSVSKLIPEALSMSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKLGLSRASRSPKSSKTKVVKKPKATPTKGSGSRRKTKGAKGLQQRKSPAKARATNSNSGKSKMVMQKTDLRKAAGRK", "length": 208 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P07628-1", "protein_name": "Kallikrein 1-related peptidase b8", "gene_name": "Klk1b8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYDNKEHICGGVLLERNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLTLKEIPPGADFSNDLMLLRLSKPADITDAVKPITLPTKESKLGSTCLASGWGSITPTKWQKPDDLQCVFLKLLPIKNCIENHNVKVTDVMLCAGEMSGGKNICKGDSGGPLICDSVLQGITSTGPIPCGKPGVPAMYTNLIKFNSWIKDTMTKNS", "length": 261 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P07647-1", "protein_name": "Submandibular glandular kallikrein-9", "gene_name": "Klk9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGQIDAAPPGQSRVVGGYNCETNSQPWQVAVIGTTFCGGVLIDPSWVITAAHCYSKNYRVLLGRNNLVKDEPFAQRRLVSQSFQHPDYIPVFMRNHTRQRAYDHNNDLMLLHLSKPADITGGVKVIDLPTEEPKVGSICLASGWGMTNPSEMKLSHDLQCVNIHLLSNEKCIETYKNIETDVTLCAGEMDGGKDTCTGDSGGPLICDGVLQGLTSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P08932-1", "protein_name": "T-kininogen 2", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLITILLLCSRLLPSLAQEEGAQEMDCNDETVFQAVDTALKKYNAELESGNQFLLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALTEVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPFLREDCVPLPYGDHGECRGHTYVDIHNTIAGFSQSCDLYPGDDLFSLLPKKCFGCPKNIPVDSPELKEALGHSIAQLNAQHNHLFYFKIDTVKKATSQVVAGTKYVIEFIARETNCSKQTNTELTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVQVQETKEGTTRLLNSCEYKGRLSKAGAGPAPDHQAEASTVTP", "length": 430 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C0S7-1", "protein_name": "Histone H2A.Z", "gene_name": "H2az1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV", "length": 128 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C2B7-1", "protein_name": "Large ribosomal subunit protein mL52", "gene_name": "MRPL52", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MAALGMLLSTGVRRLHCGSAARAGSQWRLRQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAQREKFARRVVLLSQEMDAGLQAWQLRQQEKLQEEKRKQQNALKPKGVLLQNPGPSQ", "length": 124 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P0C644-1", "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "Ppip5k1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSLTANEDEDESATAHFFLGAGDEGLGTCGIGMRTGESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPPCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLTMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASSEGQDLQREPPAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETKDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPAKPSDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPAGLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDNPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNTQMIEEKQGLGLLQETPGDGTPEFHIELAESTQSPQEPPVEISPPGSQDDTEVNQTCQEVPDTIQPCHDILEEIGQPNQEVPDISQLLLKNHDTATNTCQPCQASQLSKKVYEEICQLCQDNPEESNQLCQEVSVELGRMVHRFPVSIGSTTQETLMEIGRPTQEIPEEPCQEFSEKVGMLTQKASAISELSQDILETDNPSQELSEETDLQAQEVSEEIDQEPEVVDELSNEDIS", "length": 1434 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C7H9-1", "protein_name": "Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7", "gene_name": "USP17L7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDDSLYLGGDWQFNHFSKLTSSRLDAAFAEIQRTSLSEKSPLSSETRFDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQKIGNTFYVNVSLQCLTYTLPLSNYMLSREDSQTCHLHKCCMFCTMQAHITWALHSPGHVIQPSQVLAAGFHRGEQEDAHEFLMFTVDAMKKACLPGHKQLDHHSKDTTLIHQIFGAYWRSQIKYLHCHGVSDTFDPYLDIALDIQAAQSVKQALEQLVKPKELNGENAYHCGLCLQKAPASKTLTLPTSAKVLILVLKRFSDVTGNKLAKNVQYPKCRDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASGITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATQESTLDHWKFPQEQNKTKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTKPTDQESMNTGTLASLQGSTRRSKGNNKHSKRSLLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0CW02-1", "protein_name": "Lymphocyte antigen 6C1", "gene_name": "Ly6c1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTSHTTKSCVLILLVALLCAERAQGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDPNIRERTSCCSEDLCNAAVPTAGSTWTMAGVLLFSLSSVVLQTLL", "length": 131 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P0DKL4-1", "protein_name": "Spliceosome-associated protein 130 A", "gene_name": "SAP130A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYLYSLTLQQATGIVCAINGNFSGGKTQEIAVARGKILDLLRPDENGKIQTIHSVEVFGAIRSLAQFRLTGAQKDYIVVGSDSGRIVILEYNKEKNVFDKVHQETFGKSGCRRIVPGQYVAVDPKGRAVMIGACEKQKLVYVLNRDTTARLTISSPLEAHKSHTICYSLCGVDCGFDNPIFAAIELDYSEADQDPTGQAASEAQKHLTFYELDLGLNHVSRKWSNPVDNGANMLVTVPGGADGPSGVLVCAENFVIYMNQGHPDVRAVIPRRTDLPAERGVLVVSAAVHKQKTMFFFLIQTEYGDVFKVTLDHNGDHVSELKVKYFDTIPVASSICVLKLGFLFSASEFGNHGLYQFQAIGEEPDVESSSSNLMETEEGFQPVFFQPRRLKNLVRIDQVESLMPLMDMKVLNIFEEETPQIFSLCGRGPRSSLRILRPGLAITEMAVSQLPGQPSAVWTVKKNVSDEFDAYIVVSFTNATLVLSIGEQVEEVNDSGFLDTTPSLAVSLIGDDSLMQVHPNGIRHIREDGRINEWRTPGKRSIVKVGYNRLQVVIALSGGELIYFEADMTGQLMEVEKHEMSGDVACLDIAPVPEGRKRSRFLAVGSYDNTVRILSLDPDDCLQILSVQSVSSAPESLLFLEVQASIGGDDGADHPANLFLNSGLQNGVLFRTVVDMVTGQLSDSRSRFLGLKPPKLFSISVRGRSAMLCLSSRPWLGYIHRGHFHLTPLSYETLEFAAPFSSDQCAEGVVSVAGDALRIFMIDRLGETFNETVVPLRYTPRKFVLHPKRKLLVIIESDQGAFTAEEREAARKECFEAGGVGENGNGNADQMENGADDEDKEDPLSDEQYGYPKAESEKWVSCIRVLDPKTATTTCLLELQDNEAAYSVCTVNFHDKEYGTLLAVGTVKGMQFWPKKNLVAGFIHIYRFVEDGKSLELLHKTQVEGVPLALCQFQGRLLAGIGPVLRLYDLGKKRLLRKCENKLFPNTIISIQTYRDRIYVGDIQESFHYCKYRRDENQLYIFADDCVPRWLTASHHVDFDTMAGADKFGNVYFVRLPQDLSEEIEEDPTGGKIKWEQGKLNGAPNKVDEIVQFHVGDVVTCLQKASMIPGGSESIMYGTVMGSIGALHAFTSRDDVDFFSHLEMHMRQEYPPLCGRDHMAYRSAYFPVKDVIDGDLCEQFPTLPMDLQRKIADELDRTPAEILKKLEDARNKII", "length": 1214 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DKL6-1", "protein_name": "Spliceosome-associated protein 130 B", "gene_name": "SAP130B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYLYSLTLQQATGIVCAINGNFSGGKTQEIAVARGKILDLLRPDENGKIQTIHSVEVFGAIRSLAQFRLTGAQKDYIVVGSDSGRIVILEYNKEKNVFDKVHQETFGKSGCRRIVPGQYVAVDPKGRAVMIGACEKQKLVYVLNRDTTARLTISSPLEAHKSHTICYSLCGVDCGFDNPIFAAIELDYSEADQDPTGQAASEAQKHLTFYELDLGLNHVSRKWSNPVDNGANMLVTVPGGADGPSGVLVCAENFVIYMNQGHPDVRAVIPRRTDLPAERGVLVVSAAVHKQKTMFFFLIQTEYGDVFKVTLDHNGDHVSELKVKYFDTIPVASSICVLKLGFLFSASEFGNHGLYQFQAIGEEPDVESSSSNLMETEEGFQPVFFQPRRLKNLVRIDQVESLMPLMDMKVLNIFEEETPQIFSLCGRGPRSSLRILRPGLAITEMAVSQLPGQPSAVWTVKKNVSDEFDAYIVVSFTNATLVLSIGEQVEEVNDSGFLDTTPSLAVSLIGDDSLMQVHPNGIRHIREDGRINEWRTPGKRSIVKVGYNRLQVVIALSGGELIYFEADMTGQLMEVEKHEMSGDVACLDIAPVPEGRKRSRFLAVGSYDNTVRILSLDPDDCLQILSVQSVSSAPESLLFLEVQASIGGDDGADHPANLFLNSGLQNGVLFRTVVDMVTGQLSDSRSRFLGLKPPKLFSISVRGRSAMLCLSSRPWLGYIHRGHFHLTPLSYETLEFAAPFSSDQCAEGVVSVAGDALRIFMIDRLGETFNETVVPLRYTPRKFVLHPKRKLLVIIESDQGAFTAEEREAARKECFEAGGVGENGNGNADQMENGADDEDKEDPLSDEQYGYPKAESEKWVSCIRVLDPKTATTTCLLELQDNEAAYSVCTVNFHDKEYGTLLAVGTVKGMQFWPKKNLVAGFIHIYRFVEDGKSLELLHKTQVEGVPLALCQFQGRLLAGIGPVLRLYDLGKKRLLRKCENKLFPNTIISIQTYRDRIYVGDIQESFHYCKYRRDENQLYIFADDCVPRWLTASHHVDFDTMAGADKFGNVYFVRLPQDLSEEIEEDPTGGKIKWEQGKLNGAPNKVDEIVQFHVGDVVTCLQKASMIPGGSESIMYGTVMGSIGALHAFTSRDDVDFFSHLEMHMRQEYPPLCGRDHMAYRSAYFPVKDVIDGDLCEQFPTLPMDLQRKIADELDRTPAEILKKLEDARNKII", "length": 1214 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DML3-1", "protein_name": "Chorionic somatomammotropin hormone 2", "gene_name": "CSH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF", "length": 217 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DMV2-1", "protein_name": "Cancer/testis antigen family 45 member A9", "gene_name": "CT45A9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETAFSPKSQQEINADIKRQLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI", "length": 189 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DOV1-1", "protein_name": "Interferon-activable protein 211", "gene_name": "Ifi211", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYTTIQIANMMEEKFPADSGLGKLIEFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEAGPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQAGTSTAQAGTSTAQKRKSMREEETGVKKSKAAKEPDQPPCCEEPTAMCQSPILHSSSSASSNILSAKNQKSQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMFHATVATVSQYFHVKVFNIDLKEKFTKNNFITISNYFESKGILEINETSSVLEAAPKQMIEVPNCITRNANASPKICDIQKGTSGTVFYGVFTLHKKKVKTQNTSYEIKDGSGSIEVVGSGQWHNINCKEGDKLHLFCFHLKRERGQPKLVCGDHSFVKVTKAGKKKEASTVQ", "length": 425 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P0DTA3-1", "protein_name": "Speedy protein E11", "gene_name": "SPDYE11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVSGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DUD3-1", "protein_name": "Speedy protein E14", "gene_name": "SPDYE14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DUD4-1", "protein_name": "Speedy protein E15", "gene_name": "SPDYE15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW11-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 6", "gene_name": "TAF11L6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW12-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 7", "gene_name": "TAF11L7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW13-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 8", "gene_name": "TAF11L8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW14-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 10", "gene_name": "TAF11L10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P11588-1", "protein_name": "Major urinary protein 1", "gene_name": "Mup1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEKHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11589-1", "protein_name": "Major urinary protein 2", "gene_name": "Mup2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEKSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAKLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P13255-1", "protein_name": "Glycine N-methyltransferase", "gene_name": "Gnmt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANWLTLDKDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGAGRDGAPGFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVLGDFKPYRPGQAYVPCYFIHVLKKTG", "length": 293 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P13675-1", "protein_name": "Y-linked testis-specific protein 1", "gene_name": "Ssty1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVSCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYFVKYDGIDSIYVLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFERKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKILEVEKS", "length": 232 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15515-1", "protein_name": "Histatin-1", "gene_name": "HTN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKFFVFALVLALMISMISADSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN", "length": 57 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P16374-1", "protein_name": "Zinc finger protein 60", "gene_name": "Zfp60", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANSSSQHMVCGSVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAVVGRCIPKPDLIVLLEPEKEPWMAVKKETGRPSQGLETGFEAENRSPKNHVYNKKLPKQTIQQLSKTSDVQGVSVSNGPGYSVIKEPQNYQEGDANRNITNKKEMSTYTSKTLAHNKEKPYKCKDCGKCFGCKSNLHQHESIHTGEKPYECKDCGKTFRLPQMLSRHQKSHSDERPFECNICGKSFHLPTLLQYHKNIHTGLKPFECEECGKSFKSFNRISTLFQHRTIHAGMKPYKCNVCGKAFNRRSNLLQHQKIHSEDRPFHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNGSYLLRHYDTHTNEKPFECNICGKAFRLHLYLSEHQKTHTDEKPFKCKLCESAFRRKYQLSEHQRIHTDGKPYQCKDCWEFFRRRSNFIEHQSIHTGKKPFECKDCGKVFRLNIHLIRHQRFHSDEKPFECKECGKAFHFSSQLNNHKTSHTGQTPFECKECGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNLMQHEKIHSDERPFECKDCGKAFTVLAQLTRHQTIHNGKKSYECEQCGSAFRLPYQLTQHQRIHYDVKPFQCKECGRAFVRSTGLRIHERIHTGEKPFQCKECGEAFQYHYQFLGHFRIHTGKNPYECSECGKYFTYGRDLKVHQSIHNLEKP", "length": 707 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P20816-1", "protein_name": "Cytochrome P450 4A2", "gene_name": "Cyp4a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR", "length": 504 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P21571-1", "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "Atp5pf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVQRIFRLSSVLRSAVSVHLRRNIGVTAVAFNKELDPVQKLFLDKIREYKAKRLASGGPVDTGPEYQQEVDRELFKLKQMYGKGEMDKFPTFNFEDPKFEVLDKPQS", "length": 108 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22237-1", "protein_name": "NADH-ubiquinone oxidoreductase subunit 9", "gene_name": "nad9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKDYKNELKVKINLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNIEEIKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVNDKKIIYKPIELMQEYRNYNFGAVWGDYERKVYLENIIK", "length": 209 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P22283-1", "protein_name": "Cystatin-related protein 2", "gene_name": "Crp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYKTLCGTQLLLAIFVLFLNFSHATAKGTRGPMEIFKKNFMEKNKLNDVYDIFKFLYNKFSHDTYLSNIKNQSFTMNTWGFGEIEVVKTKCRKIDSDFYKCSFQWEFCNIKRTPGVTIYYITLPGSVRCRKLLSKLVNCPFEEQTEQLKREICYFQLYPDYIEQNIRSVRFNCYTK", "length": 176 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P23266-1", "protein_name": "Olfactory receptor 1f45", "gene_name": "Or1f45", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILAIGTDSRLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILGSQAISFSGCLTQLYFLAVFGNMDNFLLAVMSYDRFVAICHPLHYTTKMTRQLCVLLVVGSWVVANMNCLLHILLMARLSFCADNMIPHFFCDGTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITCAVLRVSSPRGGWKSFSTCGSHLAVVCLFYGTVIAVYFNPSSSHLAGRDMAAAVMYAVVTPMLNPFIYSLRNSDMKAALRKVLAMRFPSKQ", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24049-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "Rpl17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24868-1", "protein_name": "G2/mitotic-specific cyclin-1", "gene_name": "CLB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSRSLLVENSRTINSNEEKGVNESQYILQKRNVPRTILGNVTNNANILQEISMNRKIGMKNFSKLNNFFPLKDDVSRADDFTSSFNDSRQGVKQEVLNNKENIPEYGYSEQEKQQCSNDDSFHTNSTALSCNRLIYSENKSISTQMEWQKKIMREDSKKKRPISTLVEQDDQKKFKLHELTTEEEVLEEYEWDDLDEEDCDDPLMVSEEVNDIFDYLHHLEIITLPNKANLYKHKNIKQNRDILVNWIIKIHNKFGLLPETLYLAINIMDRFLCEEVVQLNRLQLVGTSCLFIASKYEEIYSPSIKHFAYETDGACSVEDIKEGERFILEKLDFQISFANPMNFLRRISKADDYDIQSRTLAKFLMEISIVDFKFIGILPSLCASAAMFLSRKMLGKGTWDGNLIHYSGGYTKAKLYPVCQLLMDYLVGSTIHDEFLKKYQSRRFLKASIISIEWALKVRKNGYDIMTLHE", "length": 471 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P25389-1", "protein_name": "Probable serine/threonine-protein kinase KCC4", "gene_name": "KCC4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLSSSSSLLLNNRSIQSTPRRRTSKRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELAKREKAELQRKVQEAKRQSVNAQKINEDEFGSEVSDGMKELKKINDKVSSPLINYEFSQQELLQDIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIETIRRSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFTTANNRRSVLSLYAKDSIKDLNEFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQYDEDDSKDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNASGLGLYQREPSKVTLPSLTSNNSSVGENIEDGAEKGTESEKIAASLSDDDLKEDNDKKDNDTVNAPTTVKKPPNSVLLKKFSKGKILELEIHAKIPEKRLYEGLHKLLEGWKQYGLKNLVFNITNMIITGKLVNDSILFLRSTLFEIMVLPNGDGRSLIKFNKKTGSTKTLTKLATEIQIILQKEGVLDK", "length": 1037 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P28312-1", "protein_name": "Alpha-defensin 5", "gene_name": "Defa5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTFVLLSALVLLAFQVQADPIHKTDEETNTEEQPGEEDQAVSISFGGQEGSALHEELSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P28742-1", "protein_name": "Kinesin-like protein KIP1", "gene_name": "KIP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ", "length": 1111 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P29314-1", "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "Rps9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED", "length": 194 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P33579-1", "protein_name": "Prolactin-8A5", "gene_name": "Prl8a5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELALSQPSFFGTLLMLVVSNLLLWEKAASIPACMVEDGGCWDPLREAFNSATQRAETLRNLSDQLYVEFFQNQFSSRQFADLSSQLIRKDETVLKAGTYCHSNRAKPKSRGVNIDIEEYLKMSINFCGFMDQPLFHLVIELSAMEGVPETILSKAKDLEENNRQLLDDLRWILTKVFPTAEIKEEFPSWDYLSFLKSSNKNHKFLAIFNLSSCLDYDTQVHYTLSQILNCLITGKDC", "length": 238 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P36006-1", "protein_name": "Myosin-3", "gene_name": "MYO3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAVIKKGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLNLFNSNPYFELRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRPPTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRDYGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKVFILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKSNKKPKNPGGLSGKPIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAATAAQAAYNPKPDKTVPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSAKQNQVSMPPSKGVEKNKEPLKETTATATANIPIPPPPPPMGQPKDPKFEAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTRNTVPVAATGAVNDVTNQKSSQIDNTISSAQEGVQFGSATVGPTSDNQSNPVGTFSDGLASALAARANKMRAESADDDDNDDGDDDDDW", "length": 1272 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P36046-1", "protein_name": "Mitochondrial intermembrane space import and assembly protein 40", "gene_name": "MIA40", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLRNLVVRNACRNRPSIQVARGLCRHQTRRLMASSPQFGRNSNQEKTAGFIMGILSMAGALYFIAPNRKPLFASRKVESDKTAEEELSSGGEQSPENEDDNNSKSDENGDDNDSKNDETEAGPQLGGDKIGASKVAEDGELVVLAEEDNKSSEDKDTDESKVSTKDDEQSNEDNATANNQKDENISSENSEENTSDKTLDNNAGSSEKKDPEHSDDEKSQQGQSDDKTTTEDNNGEEESSKKTVSDSENSAKQSESSDEEKEELRKQEEKQMGPTEEEVQHEGAYNPDTGEINWDCPCLGGMAHGPCGEEFKSAFSCFVYSEAEPKGIDCVEKFQHMQDCFRKYPEHYAEQLKETSDDEEPQDKVKVNTIESAPNVSSAKENAAKKAEQSDVKKEPLNEESKP", "length": 403 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P37106-1", "protein_name": "Signal recognition particle subunit SRP54 1", "gene_name": "SRP-54A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVLAELGGRITRAIQQMNNVTIIDEKVLNDFLNEITRALLQSDVSFGLVEKMQTNIKKIVNLDDLAAGHNKRLIIEQAIFKELCRMLDPGKPAFAPKKAKPSVVMFVGLQGAGKTTTCTKYAYYHQKKGYKAALVCADTFRAGAFDQLKQNATKAKIPFYGSYTESDPVKIAVEGVDRFKKEKCDLIIVDTSGRHKQAASLFEEMRQVAEATEPDLVIFVMDSSIGQAAFEQAEAFKETVSVGAVIITKMDGHAKGGGALSAVAATKSPVIFIGTGEHMDEFEVFDVKPFVSRLLGKGDWSGLVDKLQEVVPKDLQNELVENLSQGNFTLRSMYDQFQCSLRIPLNQLFSMLPGISAEMMPKGHGEESRVKMKRYMTMMDSMTNKELDSPNPKIFNESRIMRIARGSGRLVREVMEMLEEYKRIAKTMKGIKIPKNGDMSKVIPPQMLKQMGGMSGLQSLMKQMGSAKDMMGMFGGGGK", "length": 479 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P38150-1", "protein_name": "Inactive deaminase YBR284W", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVQNNESVFFVECDSYKESPSTSPIRLDDLDGNDAVSDQGLAFDGDVGITSQARVRNPRAQIFEDSNTDVVLHLDDLDMVPLNTKFDMQMEMGSPMAMPAETPPPVEPLKTKDLAYSSLAHLPSYFFEQTHFRIDRKCLLEMSKLRRNYLTISKQDALSCPQLHSRVAGGYLKPVKEKLFGIRHFLDLEESNTVNLLQDGNYMTELFNSQINIPTFKEFREDFEWCLKIIRDRSLSRFSEKRLQYLVNKFPVFQHLHSKEEMRQSKKVPHKDFYNCRKIDLNLLLSGCFSQWQLTEFIWTKLRKEPDRVIHQAFNGSHITLSQLFKVNFEETGQFFNGLKIIDDSFLEWYKVIYLAKYHLVNDEMEIHTGSHGKQLRYYLIAKTFLEFDNYINGEYLAELLKTFLIKPQEESKYQLCQLSVDFQFYLHYDNSDVDNWWMVFANWLNHYNIFSNNIRWNIRISRIYPELYHTGKVKNFQEYLNLIFKPLFNAENYLHKSLGPILLKFLSQVSSIDLCIQDTDNYIWKNFTAVSCLPKDWTSGGDNPTISQYMYYVYVNLTKLNHIRQALHQNTFTLRSSCSPTSMNRTSQFSNTLNFTEHTEAILNNFLLACGGFLNAENLWNAPPSLVYLFYLSQIPMVVAPLNSIVDSKPTMLQEQAPTGLVLEPSKPYKKNPFMKFFEMGFKISLSSESILYNNSYTKEPIIEEYSVAASIYRLHSADLCELLRNSVITSGFSSTLKNKWLGVSLASHDYFVENTGFVDKWYDCKPNTSLEHNVPIIRRQYRSSTLAGEWRLIIA", "length": 797 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P40002-1", "protein_name": "Transcriptional regulator MIT1", "gene_name": "MIT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLIVSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSAVITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKYTGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIVAMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSANKNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNSNNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDFINPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPTESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPYYNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYAMASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKNFAMGHANNNILNITNNDTMNNLNTNTSTTTQ", "length": 666 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P42222-1", "protein_name": "Enolase-related protein 3", "gene_name": "ERR3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIHEAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSDLCVTNQKGIDELMISLDGTSNKSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAHAGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPDIDTAEDALDMIVKAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSPAQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARAIEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLRCGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL", "length": 437 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P43356-1", "protein_name": "Melanoma-associated antigen 2", "gene_name": "MAGEA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43357-1", "protein_name": "Melanoma-associated antigen 3", "gene_name": "MAGEA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE", "length": 314 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43537-1", "protein_name": "Uncharacterized membrane protein YFL067W", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MESIILSIAIFIGVLLGTSVGAGSGSSISPDVDAGSGSRTSPDVDAGSGSRISAGVGTFSGSSTSPDVDAGSGSSTSPDVGAGSGSSISAGVGSRIGTGIGSRIGTGIGTGIGSRISTSIGSRISPDVGTSSGNRISTGVSTGISTTMNARVAVLITAAILSAPVTAIALLEARR", "length": 175 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P46162-1", "protein_name": "Beta-defensin 4", "gene_name": "DEFB4", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRLHHLLLAVLFLVLSAGSGFTQRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR", "length": 63 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P46169-1", "protein_name": "Beta-defensin 11", "gene_name": "DEFB11", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRLHHLLLALLFLVLSAGSGISGPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW", "length": 60 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P47102-1", "protein_name": "ARF guanine-nucleotide exchange factor 1", "gene_name": "GEA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MHDVPMETVLAVNPATMIVKECINLCSAMNKQSRDKSQTSVAALLGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQRSEVLRKTAEVTIAGITVKLFTKLKLLDPPTKTEKYINDESYTDNNLKDDIIGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYEKAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYFQIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQLVSPKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMINISNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRTEKVAVDNLLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRVLNVFNKYVDDPTVERQLQELIISKREIEKE", "length": 1408 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P53563-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "Bcl2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK", "length": 233 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P56840-1", "protein_name": "Protein TCL1B1", "gene_name": "Tcl1b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAFDPLGPLPVYLVSVRLGIYEDEHHRVWIVANVETSHSSHGNRRRTHVTVHLWKLIPQQVIPFNPLNYDFLPTTWKLESRNIYWATDGTHWRLLDHSQLGDTEQLILMLVLG", "length": 116 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56841-1", "protein_name": "Protein TCL1B2", "gene_name": "Tcl1b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAGFYPPRLLPQVLISTGPGFYEDEHHRLWMVAKLETCSHSPYCNKIETCVTVHLWQMTRYPQEPAPYNPMNYNFLPMTWRLASMNTYRGTDAMHWRLLNHSQVGDTVQLILMLE", "length": 117 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56842-1", "protein_name": "Protein TCL1B3", "gene_name": "Tcl1b3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSVHFPWMPFPPRFLVCTRDDIYEDENGRQWVVAKVETSRSPYGSRIETCITVHLQHMTTIPQEPTPQQPINNNSLPTMWRLESMNTYTGTDGTYWRLLDHSQMGDTLQLILDIVICEVD", "length": 122 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56844-1", "protein_name": "Protein TCL1B4", "gene_name": "Tcl1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSVRFPCMPFPPCFLVCTRDDIYEDEHGRQWVAAKVETSSHSPYCSKIETCVTVHLWQMTTLFQEPSPDSLKTFNFLPRTWRLESRNTYRGADAMHWRLVNHSQFYGTEELVLMLDSR", "length": 120 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P59528-1", "protein_name": "Taste receptor type 2 member 123", "gene_name": "Tas2r123", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSQKINYSHLFTFSITLYVEIVTGILGHGFIALVNIMDWVKRRRISSVDQILTALALTRFIYVLSMLICILLFMLCPHLPRRSEMLSAMGIFWVVNSHFSIWLTTCLGVFYFLKIANFSNSFFLYLKWRVKKVILIIILASLIFLTLHILSLGIYDQFSIAAYVGNMSYSLTDLTQFSSTFLFSNSSNVFLITNSSHVFLPINSLFMLIPFTVSLVAFLMLIFSLWKHHKKMQVNAKQPRDVSTMAHIKALQTVFSFLLLYAIYLLFLIIGILNLGLMEKIVILIFDHISGAVFPISHSFVLILGNSKLRQASLSVLPCLRCQSKDMDTMGL", "length": 333 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61314-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62246-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62425-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "Rpl7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62802-1", "protein_name": "Histone H4", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P62963-1", "protein_name": "Profilin-1", "gene_name": "Pfn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY", "length": 140 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62982-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "Rps27a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK", "length": 156 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P70709-1", "protein_name": "Eosinophil cationic protein", "gene_name": "Rnase3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLKLLESRLCLLLSLGLVLMLASCQPPTPSQWFEIQHIYNRAYPRCNDAMRHRNRFTGHCKDINTFLHTSFASVVGVCGNRNIPCGNRTYRNCHNSRYRVSITFCNLTTPARIYTQCRYQTTRSRKFYTVGCDPRTPRDSPMYPVVPVHLDRIF", "length": 155 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P81278-1", "protein_name": "Prolactin-releasing peptide", "gene_name": "Prlh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALKTWLLCLLLLSLVLPGASSRAHQHSMETRTPDINPAWYTGRGIRPVGRFGRRRATPRDVTGLGQLSCLPLDGRTKFSQRG", "length": 83 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P83883-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P83884-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "RPL36A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P97876-1", "protein_name": "Basic leucine zipper transcriptional factor ATF-like 3", "gene_name": "Batf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQGPPAGGVLQSSVAAPGNQPQSPKDDDRKVRRREKNRVAAQRSRKKQTQKSDKLHEEHESLEQENSVLRREIAKLKEELRHLTEALKEHEKMCPLLLCPMNFVQLRPDPVASWSAHDAPDHPSFIWLGTLV", "length": 133 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q00729-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2bc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEVSAKGTTISKKGFKKAVTKTQKKEGRKRKRCRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 127 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q01534-1", "protein_name": "Testis-specific Y-encoded protein 1", "gene_name": "TSPY1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS", "length": 308 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q03764-1", "protein_name": "Ethanolamine kinase", "gene_name": "EKI1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF", "length": 534 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q04902-1", "protein_name": "Probable glutathione-independent glyoxalase SNO4", "gene_name": "SNO4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFEVDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIFFASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGKAITGFPLEGEIALGVDDILRSRKLTTVERVANKNRAKYLAPIHPWDDYSITDGKLVTGVNANSSYSTTIRAINALYS", "length": 237 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q0D2J5-1", "protein_name": "Zinc finger protein 763", "gene_name": "ZNF763", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPVACEDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSIGKKWKDQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHERTHSAKKPYECKQCGKALSYKFSNTPKNALWRKTL", "length": 394 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q0WX57-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 24", "gene_name": "USP17L30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDDSLYLRGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LYG5-1", "protein_name": "Elongation factor 2a.1", "gene_name": "eef2a.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENFNVDQIRATMDKKSNIRNMSVIGAFDHGKSTLTDWLVSEAGIVSSARAGETRFMDTRRDEQERCITIKSTAISIFYELAEKDLAFIKECKDGSGFLLNLIDSPGHVDFSSEVTAALRITDGALLVVDCVSGVCLQTETVLRQAIGERIKPVLMINKMDRALLELQLVPEELYQIFQRIVEKVNVTISTYAEDEKGPMGNVMIDPVIGNLAFGSGLHGWAFTLKQFAELYVKKFAGKAQLGPEEYIKKVEDMIKRLWGDSYFDSTTGKFSESATSPDGKKLPRTFVHLVLDPIFKVFDAIMNFKKEETVKLIEKMGIKLDVEDKEKEGKILLKAVMRCWLPAGEALLQMITIHLPSPVTAQIYRCELLYEGPGDDEAAMGIKNCDPKAPLMMYISKMIPTSDKGCFYAFGRVFSGCVSTGLNVRIMGPNFTPGKKDDLYLKPIQRTVLMMGRYVEPIEDVPCGNIVGLLGVDQFLVKTGTITTFTKAYNMRVMKFSVSPVVRVSVEVMDPADLPKLVEGLKHLAKSDPMLQCIIEDTGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPFASYRETVSDGSKQLCLAKTPNKHSRLFMKACPLADGLAEDIDKGRVTASQEMNARAQYLAENYKWEVTEARKIWCFGPEGTGPNILVDLTKRVQYLNEIKDSVIAGFQWATREGVLCAENMRGIRFDIHDATLTSTAIHRGPGQIIVATRRVLYGCQLTAEPRLSEPIYLVEMQCPESVIGNVYGELVRRRGVVFSESQVMGTPVYLLKAYLPVSESFGFTADLCANTSGQAFSQCVFDHWQILPGDPMDPTSKVAHIMADIRKSKGLDEAIPALHCYLD", "length": 854 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q1PEY5-1", "protein_name": "Probable 3-hydroxyisobutyryl-CoA hydrolase 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASHSQVLVEEKSSVRILTFNRPKQLNALSFHMVSRLLQLFLAYEEDPSVKLVVLKGQGRAFSAGGDIPPIVRDILQGKLIRGAHYFKVGYTLNYVLSTYRKPQVSILNGIVMGGGAGLSTNGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSISLTALEAELYKVGSSNQTFISTILDAYAEYPHLNQHSSYHRLDVIDRCFSKRTVEEIFSALEREVTQKPNDWLLATIQALEKASPSCLKISLRSIREGRLQGVGQCLIREYRMVCHVMKGDISKDFVEGCRAVLIDKDRNPKWQPRRLEDVTDSMVDQYFERVEDEEGWEDLKFPPRNNLPALAIAAKL", "length": 378 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q1ZXA5-1", "protein_name": "ADP-ribosylation factor-like protein DDB_G0292332", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDFIISFIKNLFGFLTIKKVMILGVENVGKTTLLYNIYKFYSENITTTTLSSLPIPIPTNGFNVESIVIEQVKFDIWDIGGKETNRICYRHYLTSEIDSIIFVFDSSDINSLEESKKEYQYLKNQISLKNVPFLLVANKQDLKQQTIEIDEILKTYFDKSSINETILMSQNNNDDLIKCINWIFSN", "length": 186 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q1ZXJ4-1", "protein_name": "Acetyl-coenzyme A transporter 1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLFTLLKRHFGNELNNIVWLVLLYLIQGIPIGLSFGTIPFLLHKHATYTQIGIFTISTYPYSLKLLWSPIVDSYFVQSFGRRKSWIVPIQILAGIVFITISFFIETLLEHAETKIIYITIVFFLLIFLMATQDIAVDAWALTILSKPYLHYASTCQTIGLNTGYFLSYTIFLTLSSPKFANKFLRSVPSEEGIITLPGYLQFWGILFIILSIYLAFFKDEESTTITTTTTRHDNYNNNNNDDKNKQVKSKIENESIESKSMRSSPSSLSPSLLSSPVKKQNKKNKQHISIDKKDITIIKENNENNEIIDNNNSNNNYDNGKKSIVQETYGMDISESDLTPKQVYYLLWKIITLPHIKILSILFIISKIVFQPNESALNLKLLEKGLRKEDIASFSLIQFPSIIIFSIISSKWVKNKPLTIWSNAYLVGVFFILVNMCSVFYFPNLNGGEISWSHFFLLLMISLFSSFSYNLMSVSQGSFFLKISDKSIGGTYVTLLNTIANFAGTYPKLFILMLIDKLTTSECIVNISNDNSSSSSSSSSLISTSSNNLTTTTTIIQEQQQQVIIHDNISKELCAEQNGKYRIERDGYYLVATGAIIYGVFIYFVLKRYLTPIEKLKL", "length": 618 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q23888-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "mrpl2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVLNWRGVKSRLYSGKRRIDGRNKGLIAIRSRGGALKRKYRYIEHYKQKWMDKWLFVMRIEYDPNRSAHIALCSILKEGIYFYVISIAKLEVGSLIITSALKLGTLQVGNTTKIKNIPEGLLINNIELIENSGSKISRAAGTSSLIIKKYNKKYSLVKLSSKECRLISNECYATIGTVSNIERKLKQNKKASYSRKRGIRPIVRGLAMNPVDHPHGGRTKGGVHWKSFSGKLAYNVSSRKKTKMTSRYIIIGHRKQKIMDKQIKNG", "length": 266 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q24113-1", "protein_name": "Protein no-on-transient A", "gene_name": "nonA-l", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEGAVKKNSLNSSPLPQRQQRGNSTNKNLGKPTPPKLNAASDGNPAEKKARLGGNTQNGGGVAGGGGTGGGGGGGGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQKQINESPKPAAGNVPAKNNELSAGGGGQNQPNHSNKGQGNQGDQGEQGNQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQGDNKGGQGQRGAGGGKHQRGNRSRRSGGSGIMNSSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQEGFGGSNSGFEHFDSPFEVFGNNSNNSTMAGPGGPDNSDGNQHGHIDSWGHRRF", "length": 630 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q2PRK7-1", "protein_name": "Odorant receptor 106-10", "gene_name": "or80a10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANETFVKNVDSFIITGFDHLQNQKLLGSLILISYMFILLGNGINLCIISTDRHLHKPMYILICNLAVVDIMYSSTCSTTMISVLLAEIKTVSYYSCISRTYFFNLGDLTECMALTLMAIDRLIAINLPLRYHSFVTNSRILWLIFLTWIFSFAVIGFLTYVADTLPYCQPIIKYVFCSYSSLVRAACVDPEPYFAISTVYSMVTLCGLFPFILCTYAVLAYSVTKLANSSRKQMINTCLSHIIVLFSFYLPKIVYILLTRIGLVLTLTERNAVLIVSCFVSLLVNPTVYCIRTKGIRKRITDIFLYTQKITK", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3L180-1", "protein_name": "Alpha-defensin 26", "gene_name": "Defa26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLVLLSALFLLAFQVQADPIQNTDEETNTEVQPQEEDQAVSVSFGNPEGSDLQEESLRDLGCYCRKRGCTRRERINGTCRKGHLMYTLCCL", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3TR54-1", "protein_name": "Gasdermin-C4", "gene_name": "Gsdmc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPRSGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVGYVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSATKKKMTFPDRPLKLYDLPVTLRYQEEVIETGSWIDDIDPIGTIEEPANLNFMCLQHEVSEQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELNQLGHMDGPGGKILDELRKDSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSILQTNFKYSSNTPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLQKANSSSKPSLSPGYI", "length": 480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3U0I6-1", "protein_name": "Endoregulin", "gene_name": "Erln", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQMVPPRSIQNEDFWKNPWDVGGLTVIGLFTSTFLLFVLFAVVFGYVEKAVFEEE", "length": 56 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3URS2-1", "protein_name": "Zinc finger and SCAN domain containing protein 4F", "gene_name": "Zscan4f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIMQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSAPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3ZCQ0-1", "protein_name": "Required for drug-induced death protein 1", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVGARLRSKASSLVGRGPLGRLRRAGDEETDAIVEHLEGEDEDPESQDCEREEDGRRAGTPSARRVHLAALPERYDSLEEPAPGDKPKKRYRRKLKKYGKNVGKAISKGCRYIVIGLQGFAAAYSAPFGVATSVVSFVR", "length": 140 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4JEI3-1", "protein_name": "Defensin alpha 3", "gene_name": "Defa3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTLTLLTTLLLLALHTQAESPQGCTEDQKLLIMEDQDISISFTGDKGTALQDADVKSGVICNCRPRGCSFKERVYGECGYNGHILRLCCQPLNTMNKKSPSVI", "length": 104 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4JEI6-1", "protein_name": "Defensin alpha 8", "gene_name": "Defa8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTLVLLSALVLLAFQVQADHIQEAEEETKTEEQPADEDQDMSVSFEGPEASALQNLEIGWPLKQCHCRKFCRPYEKAEGSCRPGLFIKRKICCIQQWTPGRT", "length": 103 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4KL71-1", "protein_name": "Small proline-rich protein 2A3", "gene_name": "Sprr2a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK", "length": 83 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q504N7-1", "protein_name": "Pyrin and HIN domain-containing protein 1-like", "gene_name": "Ifi214", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNEYKRIVLLTGLMGINDHDFRMVKSLLSKELKLNKMQDEYDRVKIADLMEDKFPKDAGVVQLIKLYKQIPGLGDIANKLKNEKAKAKRKGKGKRKTAAKRQRQEEPSTSQPMSTTNEDAEPESGRSTPDTQVAQLSLPTASRRNQAIQISPTIASSSGQTSSRSSETLQSIIQSPETPTRSSSRILDPPVSLGTAYSSAQALGVLLATPAKRQRLKNVPKEPSEENGYQQGSKKVMVLKVTEPFAYDMKGEKMFHATVATETEFFRVKVFDIVLKEKFIPNKVLTISNYVGCNGFINIYSASSVSEVNDGEPMNIPLSLRKSANRTPKINYLCSKRRGIFVNGVFTVCKKEERGYYICYEIGDDTGMMEVEVYGRLTNIACNPGDKLRLML", "length": 393 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54B59-1", "protein_name": "O-methyltransferase 12", "gene_name": "omt12", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDWDKTMDLLFGFVTGHIHSRMFETILKFSICDLLEDGPKHYSEISKIIGFKNESYCYRLMRYFVPYKLFNESVVQVGLFSKTPSSTQFSKNGTLKNLGRFHCQDHHYRIFESLPKTLEMGKNQGPSSIGLSSFWEHFETDESYKQLFHNAMKDYTSLIIDRLISKISLSPNFKTVVDIGGSHGFLIGKLLESNPNIHGINFDLENIINSSTSKNENFQHPRLKHVSGDFFNSVPEADCYILKYILHDWSDEKCITILNNIHKSLKPNGKLFINDLVLDPSNYTKEAVFKDILMMQYFDAKERSINEWHQLFEKCGFKIDSVDTSISPQLMIVSKINSSNINLNDCTNFNSEIVEEKLKNSLPQFVNC", "length": 369 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54B60-1", "protein_name": "Probable inactive O-methyltransferase 11", "gene_name": "omt11", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MECSESLELVDKFACGHILSRMFNVVMKHSICDLLEDGPKHYSEISKIIGFKDDSYCYRLMRYFVPRKLFKESVVQVGVFSKTPFSTEFSNNGTLKKLAKFHCNSFHYKLSQVLPETLEIGENQGPSSIGLSDYWEQIEKNEIYKNEFNDGMIGYTTHILKFLKGKIDLSKFETVVDIGGSHGYLIGSLLDRYPNVNGINFDTDMVINSSNEKYQHPRLKHVAGDFFKSVPEADCYLMKLILRCFSDEKCCELLKIISKSMKSNAKIIILDIILDSSKYLNFDTYLDILMMETLDGKQRSLSEWIKLFEMSGFKIDKYESGSPNYLIISKE", "length": 331 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54B86-1", "protein_name": "Hly-III related family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPRLDHKKNKEEKDNEPLMMVNNYNIGIQTDNNQEDIQNDYHHFNDLSINIKNNKNNNNNNNKCNSLHHKHYHNRFIINGGNNNNDNNNNNNGDDCCANIELFVDLMLSENEYILSGFRLHTKNSYMECTKSIFKLHNDTLNIWSHLLGALFYLVLFFTSIIKIIKLNNNDGGGGGGIGNNFILNSDEIKLLETIDLPSNFNYLFFQLSCFICFLSSTIYHTYRSHSIVVFKTTLMLDVASIALLILSSVCLIIDSELSCWPYFKRIYLFSFLILILISFLSLPKIMREKRYGLRTFLFAILALQGLVGHLFKIYLQGYFDKDPNQFYNLIGAYTLFGLALSIRRFKVPESFKPGHFDVWVNITFNIVYNII", "length": 372 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54BG8-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNINITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSSSQIHRIKNPSNGKIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54C66-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKTKKYKNPFPTNSYKEPENDSDNEYILHNEEDNEDYGSNNNNINNDGFSYEDNIENSDTEDEREDYGYINYNTNNEEDDEPIDLSTPIKKKKANNKSFKPPYKNTTTTTTTTTTTPPTPPPSKSNNNNNNNNNNNNNNNNNKNKENINKESEYELNKFLDLYNDFKSESDNKVKPTATTTTTTTTTTSTSTSKLNKDKKGVIVIESDEEKEDNTIKINKRNGKRKEGEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGNEDNLKSENFNKFKKLKSFSNQPTPLPPMLSNPFLNNSGNSHNNNNNRILFNSQFTNASNLNNNINNNINNNINNNINNNINNNINNRNNNTNNYTNNNNNNNNNNNNTNNNNSNNNINNNNYNNNNNNSFSFLPIRSNTLPTIVTRRTGIQSSSSDNGNSNSNHSSSMNKRNTSKSNNKKSTTTTKTVLPPPLSSRTQEEEDYALALSISEGLNGGSGGGSGSGSGSSDNSTKTKRSKSENDLPNEETRHQVEMDRRFAEQLHREQHENINQIQQLQRRLHLNQQRTNNINRNHHGDEDEEDIEMLNLRAYQQIQQQFNQHFNQQLNQLANHPLANLFSHASRGRGRGARRIPHHPHHHHHPHQAQYLTGLSQEQLNLMTRDFSSNDYELLLQLDENINNKGATTSDIENLPVHTLNKPTATTTSTTTTTNSSTSDDNKKNEPTTDVTCCICLCEMEPGDAVRTLPCKHFFHVSCIDQWLKVNKVCPIDKKAIDEK", "length": 766 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54CY8-1", "protein_name": "Obg-like ATPase homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKGIKLFNNFTNTKQILFFRSFSTAAKGDRLKASHYVKTRGSCKSISIVGLPNIGKSTFFNALTSSNAAMAANFPFCTIDPNIGKVFVPDERLDYISDLLKTKSKIGVQLEFVDVAGLIKGAADGEGLGNKFLGNIRQTSLICHLVRCFEDKGITHVSDEIDPIRDIETIETELILADLQSLEKMLTEGKKKQSNPELQMKFDLVKRISEYLHKGLPARDVEITDMEWPVFHSLHLLTSKPTIYTCNVAEGDAATGNKYTDLVKEYSKSKGLEIEPVVISAKIESELANMEGNDETKKEFLQLYGLENNGLSKVINGAYKLLGLQSYYTASSNECHAWTFKAGWTAPKAAGVIHSDFEKGFIKCDTISYNDFIECKGDEKIAKEKGKQRSEGKAYIVNDGDILFFKFN", "length": 409 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54D44-1", "protein_name": "Probable polyketide synthase 42", "gene_name": "pks42", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIESQREFNCIGGDNQNGVAVIGVGFKIPLDLENCLSSPSELYSALFNEFDSVTKNTSSRWSDNYFKNGDIVSLSAGLLPLREIKSFDPTFFGINPSDADLIDPQQRLLLKCVWNALEDGGIDPISIRSSDTSVYIGCSTIDYFLLNRNPVDPHNHGIQTASYSIPNRISYCFDFRGESLFVDTACSSSLNAVHLGYNSIINLKSKLSIVGGSNLILDPQNSIFFSKQQVNGPSGKCNSFSEEADGFVRSETVGVVVLKNLKDAIKDGDRIYCVIQGSNSNVDGNYEKLNYISPSKLSQAENITKALKSTNGAVNASDIDYFECHGTGTPTGDPIELEGISIALNRTQQSTTLSNPLLIGSIKSNIGHGEASSGIASLIKCCVMFKYRQFLPNINFKTPNPLIKFKEWNLKVVTEPVPFNNNKQTIMAINNFGVSGSNCCIILSEYKSNNNNNNDFKATTHLKSKKFIIPFSSNSSTSLDNYKSLLSNETNNFQDFVIKQINNKSTSLIQRSVIIASNWSEFNESSNEIQSNIKKSIISNITIKKKNAVTVFVFCGQGSQYNKMALSLYENEHIFKSTMDKLDKELSKHYGYSILEKLRSITDEDLVTIHQPILAIPVNVMVQVSLYELYKHWGIKSDIMVGHSFGEIACSYCSGMVDFKTLCYLTYHRSVAQNKTIGSGKMLSINIGAKEYLDSYSTKYPSVEIACYNSETSIVIAGNEELLNEISKDLKSKDIFTAMLPSLSAFHTTHQSVIKDDICSLNFKSTLSKITVFSTVTSNQFGINNNNNNNNNQLNSNYLFQNVIQPVKFSETISNIYKYIESNDMGNEITFIEIAPHPTLQYYLNQMKSQQSEYFNNGEKISIYSACNKKKNDYNEFLKTISTLFVNGYNNINFKSQIINNNNNDNNNNFNLPLYQWDDNEYYKIHPTWKKANKNGPSINHLGNLNDSSIKSFKTYINTRKPQFQWLKGHSLKGKVVFPGMGYISNLLSVYNMNQDITINEIQFKSAFILVDGVNNCLETSIVPLTKNEFNIKFHFKDLKTNKWVLCANANYSLFKHNDNNDKLDIEKLKSNCNYTIISKDELYNNIRAKSGLIYKGLFQGVKEAFIGNRCSLTVLSLNEIENQQEFKHLLENRNFNSLFNTAILDSCLHGSLHSKEQSQIYFDKCEGFKYYSNNINLATSKRNEYKEINVYIETNPVINSTVIVSLKIMLPDGTLLIEIQKVVCKSSIPIIDSTSVIQPSPKDLHTPYYQPKNSLIKPPQSFKHLHCMKEFASIESDNREMVYMSIYHLIFKAINARSPTKINLESLENLTLDQFKELIKDSAANIQRSNQFIYECLKLYHTNHSNYKKNQIKDFIKECEDFNGYNQIIFKTIKIYAKSLFPLPDDDPFTDTIQSLFEDDQLENVYIHLKHLYPVNNLLSEIVFQSIKPIINQTSTFRILEIGAGYGTISQLIFDKLEQLLADNFTSSRIDIEYTFTDISNTFLPRAKERYSKYKRFNIIYKLLDLELPLTEGIQDFRPLYYDIVVMSNVLHVVKDINFSTNEIYKVLKQNGQLIFVEPTYKNLYLDTIFGIFPQWWSFNDDIRTDRCCLEPSKWFEFLETINFKDTIILGQDNKEILKNVENSIILVQTRKPSQLELSINNSPSTNQFKSFENIILYTDDNQQPNDCSEIIDLLKSLELPIKIINNIDQFNQIIKTQYNNNNNNNNNNNNNNNNNNNNTNNNLIIFLKSVNQLNTNNYKDITFEYVQINQILVKLELEENYKLLLITNNSQSSNYLSNSLIGTSRYLFADIVSSKLDIITIDFDTVSIKNHQNVISVINHLLDSKDNSEREYYIINNEINIERYKNESNIKHQLKSKTFQENKDELMVQLDSNLEYRLKSKSKQELKSTHVEIQVKAIGINYKDYATYSGLIDSIIEIDKDKEKDENYDQNYPSIGNDFSGVITRIGSDVRKFKVGDEVCGLAPKTSASHIITEEGYLCKKPSNISHSEAASSVTVYTTSFQSIYSIGDLKKNETILIHSGSGGIGLSALEILKWKNHQGYIFATVGSEDKVKYLTDTYGSFITGIYSSRDKDYQDQIKEKLKSLGCDIDHQGVDLILNTLSVEYMDSNFKCLNQKGRCIDLSITHLTPFDYMDYNKFKFNVSYGNIELVVLPSKIIKDHLKKMLKAFSLGSLRFIPIVEFSNLNIRNAVEYINQRKHIGKIVVKNDVDFINKLFIEQQQQQNSVENNEILMKDKYDISNLELGKNILLTGQTGIILTILKWLYKHSNNSIENIIIISKSKLKWELELFINESTNNRIKIHYKQADVGNNNELNQCFEELRLRHSIEDINSIFHFAFINDIGQFEDVNMNRMDIAHHAKAIGSLNLHNQSIERKWNIKQFVLASSALSVFGGDNQCCYISACSVLDSLSKYRKSIGLPSLSINFGGVTSTGFVSRSGAVEANLESSIINLITPQSLISSLDLFIQNSQTFSNYTHFNFIYDNIESYSLNRMLFKFDYLINQHSSLVSNKRLGGINENNNIGDLLVSKIGELLSIEPSKLNLDFRLVDYGLDSLVIVQLKNFIDKQFQPHLISILQLQNNKISTTIEIIIKGYNNNQNKKIKNEQSNDIPSVVQKETIKDNNENKDDIKIDMDDKKENLKGKKENIDDKKENNN", "length": 2655 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54E06-1", "protein_name": "Transmembrane protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTIINNDNISLATSAKLSQFIVSGDYKGPFTIIGLKTKILSFSLVIEFILLKIELIKERKDGLKINFDDSISGSCNYELNYTKQDTLFQRFQSKFKIEHTINPENGETINTGITLKKLFIISIPMSILFVALNWIWMLAISMTEVSISTALYLKILKTISVIIFMGGIVGIAITTVGTSKGEYPHAIKGEILMIISAAMWGLYEVLTSKFIGDANRTIVHTYMGLIAFVNLILGIPVIVILNVTNFEPFSVPSISVFGMLLLNAFVGFSVNYLINWGLSVTSPLFVRSGELMVIVATLLFDIIIKHMKLPLLALPGYSLIVIGFILSVYIESRDIKQQQEKEKEKQKNNNGETESLLNY", "length": 359 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54EC9-1", "protein_name": "DUF781 family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLNKIILIFFLINNIFSIVVSSTKLNPWVFEERIKLYDILINSTKVEIFGDDNLNNCFQGFKIQLEWQKTTGRSMIIDNSNISVNSWWGSMNYYESIIPFISAMNLGIIQPPIELVNIGDDRFCTDYSECDKELMEPWDLYFQFLIKIKDEKYSYSIQQQILKYNWDGHMKSLSIGLKLFNDKLNYLSKNEIKFSTGFVHFVDIISLINFNTNYSQILPIFDSLPPRMLTNSDHPPFFKGFTRTQNFYTVSVLSINELHENQILWNYFLNLLKTKTENEKCRDFINQEIINFTKYPESTLVKLLLKLLLNNC", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ED6-1", "protein_name": "Probable polyketide synthase 41", "gene_name": "pks41", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDSKNLVDENCNKVAIIGIGFRFPNLKGDITPNELWSKLLNRYDGIVKNDRWNESFFKSGDISTNYAGFIPFEELKSFDPLFFGINPSEGIHMCPQQRLLLKCTWEALEDSGIDPIEIRGSNTSVFIGCSGADYQNLNKNDNKVQQEIFSSSTHSISNRVSYCFDLHGESMTIDTACSSSSNAIRRGYKSIIDGSSNISVVGGINILLDPNISKSYSRLNILSKDGKCKSFDAGADGYVRSDAAGIAILKNLNDAIKDDNNIYCVIDGSASNVDGNGFSDKSNFYSPSKSSQVECIRLALESTNGQVNENDIVYFEAHGTGTPTGDPIELESVSIALKTSENRSSDNPLLIGSFKPNIGHTESASGISSLIKCCLILKNQCFVPNLNFNKPNPLIKFDQWNLKVVTDPIDFSTLNYINKRVSIAINNFGVTGSNCCLIVSSFKGNQIRNNINNKSKSPKQYLIPFSTNSIKSLDLYKSRIDNNVEFKEFAENQIKSKSKKLIQRSVVIASNWDEFNLKSNTINTSNDKLTSNMLVSSNKKNVTMVFVFCGQGAQYSTMAKNLYDNEPIFKKSMDKIDSKLNEYYGFSILEKLRSFNENDLKGIQYSIIAQPSTCMVQISLFELYCHWGIKPSIIVGHSLGEISSSYCSGMIDLDTFCYLIYHRSMVQSKTNGLGRMLSISIGENEYNSKYSSRYPELEIACYNSPSSIVIAGKELILNEIIKELKKDGVFCAILGSPTSFHTSSQLSVKDEILKISFKSKQPTIPIFSTVTTNLYDEMNPFDTKYVYDNIINPVRFTNTISNIYKHIELNYSVNNNSNEVIFIEIAPHPTLSFYLKQMVPEDKKQSVSIFSPLSKKKSNDLFEIQKLISELYCLGYNGIGFNIQLSDHNNTNNQTRVNLPLYQWEDQEYWKLDNLHQYHLSNGPSINHLGISNSNHTPIKSYQTHINIQKKPFQWLKGHQIKGKYYFPGCGYIDNILKIFGESKTDTNPNKELPDILISFIEFKTPLIFMDGISQCLQTNIHSTGKKEYKALFHFKDEKSSSDWVQTSTANFQLFSRGPNLNEDDEQSLFMYNINDLISNQCNLTKLSKQELYSHIKTKCGLNYSGDFQRVDKCYLGYNCSLSEISIIQGVNENRSTFFDSSIIDCCLHGSIGLIDENCQLVFEKLEELTYYSSKVPKTTSQHSKIYVYSKLKPRIGDSYSASIIVMLENGTVLFEMENASFKSTTKIKDPLAMEYPTNEIYSCNLQSKDSLIPSLSSFDHIFKRKIPNEYVDQINIYESFIPKLLFSNINKRCPEITIDEIQSSEIEQLLLKYYKIKEDNDNKWLSRLFTFAFESIKQWYHNEDYDFENVLSPHNFKIFSKSTKIISKLLFPLENDNDEDSPQSLFEGGLLDKFYSSGFSAQNELVGEIIQESIKPILNEKLVFRILEFGGGVGSLSLLVLEKINSLLIQYPNYQIDIEYTWSDISPSFITEAKAKFEKFNDRFNIIYKALNLEQPLIGEKQGLKPQYFDYIIMFNVLHVIKDVKYGVEQIYQLLVPNGHLLFIEPIYKSIIGDGIFGVFDQWWSFQDTEIRKDRCCMKQKTWYKLLKSVNFNDDIRMTPELTCFVIQAQKPSISNLSFSKSETTNYDSIIVFGNKYASNLSNHFIKSIDNGNLQFISTIEELNKIGKYISNESIIYFIKSIDELSVDNFVNITHEYTQINQKLMELNCKCKHVLITNDSTTTNYLSSSLIGAARYYHECPLELFILNFDTPSIIENQNLFKTIEPLINSSINIQREFIINNHKVYYERIKNETKLKSIFKNSSSFESLEQVDNFMISLTPNLEYKVKVKPTSILKENEVEIKVMSTGLNYKDYLIYAGLVESVEPIFGIEFSGIITRISTGSKEFKVGDHVYGIGKSTTSSHIITDIDVISHKPSNISHSEASSIPVVYLTSYHSLYNIGALKNNETILIHSATGGVGLSTLEILKWKGHSGLIFVTVGSNEKEEYLRENYGDMISGIYSTRNKNFVKQIKSKISKLNPFGKSGVDFILNTLSSSDYMDSNFKCLNMSGRIVDLSITHLNSNEFTDNKKFKYNYGYHNIELQYVDKKIIKSTLSIISNAVSSNDLQLIPITHYSIEKVKESIEFINERVHMGKIIINHENQDSIINELIEKQKSINKFDQSIFKQNYKLEPSLLGRNILLTGQSGIVLEILKWILRNSENNSIGNIIILSKSSIKWEMEYLINKVKLINKLGNFFNNIKFHFKSVDISDSGLIDESINKLLIENPDINNIDSIFHFAYTQATCNSDEVDLHHLTQSHSAKSMGAINLHNQSIKRNWKLKNFIMSSSVSSKTSTANQCGYISSNNVLDALSKYRISIGLPTICTNYGLIESTGFVSRNESVAALLSGEGFIPISANLILGTLDLQLQNQAQSSNLILSNFNFTSLNGLPQKSLISKFDYQININEENEKSKSLLKDDNVELTVDQLITFKISEILSTDILKLNKDIILVDYGIDSLVIIQLKNWVDKEFSIPNELTIQKIQNSTINSFIQLVKNSMDKNKK", "length": 2542 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ED7-1", "protein_name": "Probable polyketide synthase 40", "gene_name": "pks40", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDYKNKYQSNENCNKVAIIGIGFRFPNLKGDLTPNGLWSQLLNKYDGIVKNDRWNESFYKTGDIPTKYAGLIPFEELKSFDPLFFGINPSEVIHMCPQQRILLKCTWEALEDSGIDPIEIRDSNTSVFLGCSNFDYQNLNKNNNKIQQNIFASSSHSVSNRISYCFDLHGESMTIDTACSSSSNAIRRGYKSIIDGSSNISVVGGINILLDPNTSKSYSQLNMLGKDGKCKTFDADADGYVRSESAGIAILKNLNDAIKDGNNIYCVIDGSASNVDGNGFSDKSNFYSPSKSSQVECIRLALESTNGGVNENDIVYFEAHGTGTPTGDPIELESVSIALKTSENRSSNNPLLIGSFKPNIGHSECASGISSLIKCCLILKNQCFVPNINYNKPNPNIKFNQWNLKVVTDPIDFSTLKLSNKPISIAINNFGVTGSNCCLIVSSFKGNQTNNNNNKSKSPKQYLIPFSTNSIKSLDLYKSRIDNNVEFKEFAENQIKSKSKKLIQRSVAIASNWDEFNLKSNTINTSNDKLTSNMLVSSNKKNATMVFVFCGQGAQYSTMAKNLYDNEPIFKKSMDKIDSKLSEYYGFSILEKLRSFNENDLKGIQYSIIAQPSTCMVQISLFELYCHWGIKPSIIVGHSLGEISSSYCSGMIDLDTFCYLIYHRSMVQSKTNGLGRMLSISIGENEYNSKYSSRYPELEIACYNSPSSIVIAGKELILNEIIKELKQDGVFCTILGSPTSFHTSSQIPVKDEILKISFKSKQSTYPIFSTVTTNLYDEMNPFDTKYVYDNIINPVRFTNTISNIYKHIELNYSVNNNSNEIIFIEIAPHPTLSFYLKQMVPEDKKQSVSIFSPLSKKKSNDLFEIQKLISELYCLGYNGIGFNIQLSNLNENDNIQTSLSLPLYQWEEQEYWKLDSLYQHHLSNGPSINHLGISNSNHTPYIKSYQTHIDIQKKPFQWLKGHQIKGKYYFPGCGYIDNILKIFGDNSESTTNPNKELPDILISFIEFKTPLIFMDGVNQCLQTNIHSTGKKEYKALFHFKDEKSSSDWVQTSTANFQLFSRGQGLNEDDEESLFKYNINDLISNQCNLTKLSKQELYSHIKTKCGLNYSGDFQRVEKCYFGNNCSLSELSLSQGVNENRSTFFDSSIIDCCLHGSIGLIDENCQLVFEKLEGLTYYSSKVPTTTSQHSKIYVYSKLKPRIGDSYSASIIVMLENGTVLFEMENASFKSTTKIKDSLAMEYPTNEIYSCYLQSKDSLIPSLSSFDHIFKRKITDEYVDQIKIYESFIPKLLFSNINKRCPEITIAEIQSSEIEQLLLKYYKIKEDNDNKWLSRLFTFAFESIKQWYHNEDYDFENVLSPHNFKIFSKSTKIISKLLFPLENDNDEDSPQSLFEGGLLDKFYSSGFSAQNELVGEIIQESIKPILNEKLVFRILEFGGGVGSLSLLVLEKINSLLIQYPNYQIDIEYTWSDISPSFITEAKAKFEKFNDRVNIIYKALNLEQPLIGEKQGLKPQYFDYIIMFNVLHVIKDVKYGVEQIYQLLVPNGHLLFIEPIYKSIVGDGIFGVFDQWWSFQDTEIRKDRCCMNQQTWYKLLKSVNFNDDIKMTPELTCFVIQAQKPSISNLSFSKSETTNYNNIIVFGNKDDSNLSNNFIKSIDNGNLQFISTIEEFNKMTKYISNESIIYFIKSIDELSVDNFVNITHEYTQINQKLMELNSKCKHVLITNDSTTTNYLSSSLIGAARYYHECPLELFILNFDTPSIIENQNLFKTIEPLINSSINIQREFIINNHKVYYERIKNETKLKSIFKNSSSFESLEQVDNFMISLTPNLEYKVKVKPTSILKENEVEIKVMSTGLNYKDYLIYAGLVESVEPIFGIEFSGIITNIGSGNKEFKVGDSVYGTGKSTTSSHIITDIDVISHKPSNISHSEASSIPVVYLTSYHSLYNIGALKNNETILIHSATGGVGLSTLEILKWKGHSGLIFVTVGSNEKEEYLRENYGDMISGIYSTRNKNFVKQIKSKISKLNPFGKSGVDFILNTLSSSDYMDSNFKCLNMSGRIVDLSITHLNSNEFTDNKKFKYNYGYHNIELQYVDKKIIKSTLSIISNAVSSNDLQLIPITEYSIENVKDSIEFINERVHMGKIVVDHENQDSIINELIEKQKSIDKFDQSIFKQNYKLEPSLLGKNILITGQSGIVLEILKWILRNSENNSIDNIIILSKSSIKWEMELLINKTKLLNSNSINSMGNYLNKIKFHFKSVDISDSGLTDKGIHELLIENPDINNIDSIFHFAYTQATCNSDEVDLHHLTQSHSAKSMGAINLHNQSIKRNWKIINFIMSSSITSKTSSANQCGYISSNNVLDALSKYRISIGLPTICTNYGLIQSTGFVSRNESVAALLSGEGLLPISTNLILGTLDLQLQNQAQSSNLILSNFNFTSLNGLPQKSLISKFDYQININEENEKSKSLLKDDNVELTVDQLITFKISELLSTDILKLNKDIILVDYGVDSLVIIQLKNWVDKEFSIPNALTIQQVQNSTINSFIQLVKNSIDKKNKK", "length": 2552 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54EN3-1", "protein_name": "Alkyl transferase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNCSNNSENCNINDNKKKEENVKNQNSNKNSNNNNNKSNIESIILNKKSKFSSEKELDEKENKDLKDLSNNKPINIDEYEGLPRFENEQNARSKSSLWSKLCDWMYDQNFKIASSTLKNGPIPKHIGVIMDGNRRFAERNHLETKEGHKKGFNTMLDLCQWGLTLGVKIISVYAFSIENFKRSKSEVQDLMELANNKFTEMISKSHKLQQLGVRIRVVGDHSHIPEKTKSILAKAVKSTENNTKALLNICLSYTSHEEILHSMKILSKGVNQEKKIEIEDIDQDLFENCLYIKEDLDILIRTSGEYRLSDFMLWQSCFTNLALVNTLWPDFSFFHFIYIIFLYQFNSKTLKNEIQNQYKFNNNNNNNTDNNNNLKENIKNLKSDQRVKEFINHLKISEEKLFDEFISKYNEEEEEEEEI", "length": 420 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54F52-1", "protein_name": "Saposin B domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLIFIVCLLLIFNYFIGISFGNKQINSNQQQQIINTDKNYNHNKNNKIIVSHNKNNNNNNNYNEIETENLGCTFCKYLTEKVEEYLQANSTEKEIISYLDEECELLNSPNLVLTCQNLVQQYTPIVIELIDNNESPSVICENVNICPTSSSSSSSSSIEEEIIKKLNIDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEEEEVNTCEICNLVSNLIEKYIKINNEVDEIRELIENECELLSNSKVSSCYSLVDQYFEHFYVTIENNYSANEICQLFQFCPIESSSSSSSSDIINNIPLQDSGCTVCTVLANYAYKVQANESIPEIIGSMDEICNKIGAWRDICNSIMRSGGQQLVEDIVNKGEGVYTACSNIGYCQSSSSATGTSGFSSGGSGTSTGGGYSTGDFYYKPLK", "length": 416 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54GT5-1", "protein_name": "Endoplasmic reticulum junction formation protein lunapark", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGNLFSKKNGFEKQLLDMETKILNLEDKLSNSRIFHQKVLHKIVLYSFAIEFFIILFTYVKSRSLESIPEKLFCCIYLVLFPIFILILTKVYGFVYKYLIKKNEVRLDSLKTGLQKKLDERKRETDYENTQKLLDRYEKNPPSPTNKPLGPPNLNNNNNNNNNNNNNNNNNNNNNNNNTLGNSMRNRNQPFNISSQQNQQQQRMIQPQQLSPQQLQLLQQQQRLSQQIVPSQQQQSQSQPQQQQPILNQPYNINNNNNNNKPPPPIQLPPQQSSQYIGNQQRLPPQQYQNEQKSKWWLDKLVDYLISDGPTHGSPLICSNCHSHNGYVPVEELSNIQFRCRVCKTFNQRDSVNNSTTNDDRNNSQNTGSNQQQSQSLQDQQPSIEEIDKNFSVTEQKNETNNENYSDSEKQLEENNNNNNIDNDSGSSSSQNTPNKKKGKGKGKGTPTKKTN", "length": 452 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54H60-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLDFFHLKDVDEFFRLLEKKNLQNLDNQIDGPGNLNWRTTYTEKDFSKVPKFRGIIHIVQIRDLGTKIHRDLLYEIMFEKLLDIARLNNESKLLKNEIQDLKTKLDEYHNNNSTTNTDLIINSFINVIDTTTTTTTTKTTMGATSIDKKQSEGDSIDKSIELDFFKIKSDQSQQSSPSHKLEEKQNQVNNITNEIPQESIKTVKQQTQTETNQQTFSSTSPSHQNEEKQDKQEEVKQEEVKQKEGIQKEDKKEEDKKEEGKQKYGEIFIIEIPQEEEKQKEEGKQQDGENFIIEIPQEEDKQKEDKKEEDKKEDKQEEDKQKEEKLEDKQKNGEEFIIEIPQNETLEIKVDTHPRSSNDDVSTAEMEVEALKTPLFAETTFVTKQQVITNKKLLVYKQSDFFPNMTTLLQSRLKDVTVQEVKDLTKIGLNDNSYSVGDFENVFVLYAVSCMGARTDSERDAFKIKSIRSIIGDKVPIIYGVFMIGKNGPTRIKVEHTQTSISITHSMSDIGRNLQNNENLKQLQSFLQQ", "length": 529 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54H72-1", "protein_name": "Tudor domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNIDFEDYEFYDDSDFEINTVDESVMTYSSVFDFLRFGKIPKFDTQTKMKHFKDNISKYRIESKDILHTNVDSKILRRLSEIPRVEKIFPDPNTLQLEVFKPNHELRNSNGELLSKHRPLQETLKLIEKQYYWECKFIHTSMEVDITKLYSFCDLCSQSSVSRDMDIDSNDEDKILEQMDIVEKSFSNDRNNNNNNDDNNKSIDEKDKMNICGIGIDLEAIKEGKLFEDELAEALGFPEYNSSVDNSFNSSVNNSNLNNSSLNNSLNNSKNNNNNDDDNNNNNNNNNDDNNNNNNNNNNNNNIISNIDNNNNNNNNNNNISNIDNSNNNNNNNNNNNNPVNDDFSFIIPKDYQSKNHLNDNENKDDEKDDDKDDDKDDDKDDKDDDKDDDKDDDKDDSKDNGYIKTNVSLSSSSSSDNERDDGDSHSDKSVDNDENNNNNINNIISDCNNNNNNNNNNNKINGRTFTSRRTRSDSNTSNSSVGSYISNSSKSSANSYDFSSSDQDYKSPNSPTVKKTRGASLVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNSILKPKLKSKRASASTAINSFISQFITPKHPPKSSSRLKRANRSNDSSDSGDSSSNNSSRSSSDSSDNENNNSYYLPIQSRRSTSKQILKDHLKSPTKKPRRIIEEDFYHVEEKKSPTSKISTPISRSASYNFGRSSPGSSPGSSPSLSPYSSPPQSPPHVYNHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYNNNNNNNNNIRSILKSPQSPSISPIKTPRRSPQQQQQLQLQLQNYIPMPTKTKTPTKAPYVPNYALAPIEPKPTQKTPVHVFGGNQLSVKKRQTIEDMITEVLKMNVDTAALKLPLPKVGQHVEGKSNMEDYKDAWFKGVVKEVLPNDFFLISYIDGGEEELSYTRLKPNLTSELEPLKLEEIVVGGEYLGSYRNFYYNVYVLEILRHSIRVYFADLEMAKTIKYSQLYLLSSFVKR", "length": 998 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54HE0-1", "protein_name": "Conserved oligomeric Golgi complex subunit 5", "gene_name": "cog5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNNNNNNEGVSSSSSSSSSPLPNISSPNLISNSNIENDIEIKKKSNNNNNNIFEGDNSHIYNQFLGEDFNVVHYTSNALKVSSISLSLNTLTSCTRELGQELTENITTNYDDLFKLANNIKELDQLTDTLKLGVSNLEESIQRMKNDISEPYNKVKSHIGQLKRVQDSCELLRKLIRYIQLVKKLKNHLQAGSRDLSKSAQCINEINLLKKDSDLTGINIIDSQVVWIKTCSDQIITISSTLLYQGMENQNQTDVANSLQVFHNMTILNEKVYSIVNLTTEKVIKNIKALLNVNKLIADLPKTTITNNINNNNSNNNITTNNNNNNYNNNNNNNNNNNIISTSTDKSIWLKFESLIDTLYSSLIQILHLQRVLLKIKDPLTHKSLMEVLLIKQHQLQQQQQQQQQQQQQQQQQQQQQQQQQQQVGTTSNNTQPILIEMISTLFWKSILKVLENNLLVAAKSSNIIENTFIREYPKVSKFFLDFIKKLQNYIDIHQMDIQQQFMIVLSNINQIIGNNNSNNSNSNSNNSIESSLSTSSSSSSSSSSSSSTTTTATTSLILLSADDYKLSLFKSIGLFEKAYLEYSQSKMSTIVNGLFPQSTWSSRSTLPVIPNGKQLVDLSKTIWSEIEWLVGNNDRQLLGKLMLVVSKVIDLFSSKIESMVQPPGLIVLNSNIGSSSSTGGVNNNSNSNNNNEIITINENSKPTPSQTVNTLLFNVSIQLNSSIQSLLTSQPLERESIIVIEKSLNSLITICTNIITPLMNSFFTHIEQIFSTIHNEDWYNEKTTKMLINKSNQTCSSYMESFKTLVNYFQNQYLMRFTPCQLLNNQIKSMISKIFIVYLKYCSLLKQPFSENGKLKMVNDLTHLEFAVTPLLVSGGIKEIGESYNLIRNYKQSIFN", "length": 898 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54IX3-1", "protein_name": "Probable polyketide synthase 26", "gene_name": "pks26", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METNNNKNIQEDIAIIGFRIPGCQDNTPSELWNNLMNKFSGVGKTTERWSDNYHLSGDINNGNSGLLPLKEWKKFDPAFFGINPTMVSTIDPQQRILLKCTWEALEDAGIDPIKLRGSNTSIFIGCSTGDYLDMVKSNNEIQTNLFGSVNHSLSNRISYCFDFHGASMTIDSACSSSLNTVLLGCQSINQGKSNLCIAGGVNFILDTTIPTAFSFLNILSKNGKCMTYDEGADGFVRGEGAGLVVLKSLKDAIKDGNNIYCIIKGGNTNVDGNGNADKANFFQPSKQSQSDNIKLALESIKKKSMLDIDIDYVETHGTGTPTGDPIEVEGISKVFKENHSPENPLLIGSLKSNIGHMEAASGVTSLIKCCLMFKNKSFAPNVNFQKINPKIKLDEWNIKVVTEAIPFKKNKITSMVVNSFGVTGSNCCLVLTESINNNNNSNVDKITKNEKEYLIPFSANSNQSLKNYIEEVSKIDESLQFEDFVYKQLSNKSTSLFQRFVVTSKDWKELKYKLSQPLPLKEISSSISVKKPNPITVFVFCGQGSQFNKMGLELYNNDKNFRNYIDRFDKKLLEYYGYSVISKLRSIDDNDLITIHDPIIAQPATAILQISLFELYKHWGINPSFIVGHSLGELPMAFCSGMIDFDTVCYLLYHRSLAQSKTNGCGKMLSCNISSEEFVKNYSPRYPFLEIACYNSPNSIVVAGKESILLELSKEFKNSGIFCAMLGSLSSFHTSSQLEVKDHIYSLKFESKEPVIPTFSTVTTHLFNSNKLYDNDYIFQNIMKPVLFNETISNLYKHVENNQLGSEMIFIELAPHQTLSFYLKQLIPKDSNYFSNSNSITILSPLHKKKNDYLEIQQTISTCYCKGYDVNFKSQILIESKTNISNKSLPLYQWDDKEFWKDLEKQKRILQGPPMDTLGFSNEKSPILKSFETKIDIKKKPFQYLKGHIVKGKIYFPGVGYIENLLKMYPSQDIDIDSMEFEAPLILIEGIVTCLQSNVYKIGKNEFKVQFHFQDQKTKQWIQSSFANYHLSHRDDFDPTTNKLNIQNLISNNCNLTKLSKNQFYNFIKAKAGLSYNGEFQGVEKCYLGDNCSLVEIPFDTSNQDVETNINMIPILDSCLHGVHILYVEQCQMVLEKIEGLKYYSSTLILSKQKEQQKLYVFTRIENKDLINNSISASIIVMISDGTVFFEIESVSLKSLIPLKDPISIENPTDELFSSYLQSIDSLISEPSSYKSIYKRNEFISSGMSDLSRSDYQQFISTLLYTNLIKRNQSIESDLRNQIEFEEIKAKYCKNSKFERLFTFVIETIKQYDGINGNLNSWNEGNIDIYKILIKSTRIISKLLFPLQGEDTTIDTPQSLFENNLLDDFYNINGNTVIQNQLVGEIITQSIKPLINEKMVFRILEFGGGVGSLSIVTLNKINQLLEQHPNFQIDIEYTWTDISPSFIPDAKKLLSNIKGVTIIYRSLDLEESLIEKQLLKPSYYDFVIMSNVLHVIKEIKFGIDEIYKVLSPNGQLLFIETPYRMLICDSIFGVFDQWWGFTDTGIRVDRCCMKQKTWFKLLSESNYQDIIMSDDIKDCCFVIQAKKPSISSLEYKLKIDSQENDKIIVFGENDTFMKYLENKSTKQIIKIKTCQQFSDLITSNSKEINNQSIIYFIKTLNQLLIENFKEITLEYIQINQLLLSSGLSCKHILLLNQSTSENYLGSSISGAARYFDEFPPLKLYSFDFDKYSLNNESINIIDDIIEPIIKSMNNSNIRKELLVRNNKIFFERYKQEKRIKENYKSTSFENDKSLFVHLNANLEYELKSKQVKLKQNEIEVNVKATGINYKDYLVYTAMTPSELINHKGESNPEFGHDFSGIITRIGDDDGDNDNEFKVGDQVYGIWFNTTASHIIVDKEFLCHKPSKLSHTIASSIPVVYITSLYSLYNIGNIQNDESILIHSASGGIGLSALNILKWKNHKSHIFVTVGSKEKEKYIHDTYGDFITGIYSSRNKDYLKLIKRKLTELGSNKKGVDIILNTLSSSEHMVSNFKCLNHRGRIIDLSITHLNHNEYTCNNNFKYNYGYHNVEVLFVKGDIISKLLKNITSAIENGSLSTGIPIIEFNDSDCFNAIEFINKRQHIGKIVVNHNKENLIQELIKKTNLPIIKSNYQINSDHLGKNILVTGQSGIILEILKWIVKYSTNVENIIILSRSSLKWELELLVNKNKNKLNFIYKSVDVGNSLEIEKVIDEILMENPQINNVDSIFHYAFTQISCKEHEIDQVHLNVSHQAKTMGAINLHNQSIKRNWKLINFIMASSAAGLIGSTDQCSYVCSSNVLDTFSKYRKHVLGLPSICINYGLIESTGFVSRNQSVAVMLDGQGIRPMQTNQILGSLDLFIQNPSKSTNIILTSFNFNEFATGNLQQSNVHKFDFQFNCCLSQKSKLMANNQASENPVKDLLINNICELLSIDESKLNIDIRLIDYGSDSLTIVQIKNLIDKNLLIPNLISIQMLQNNSISDNIKILTDSYNKKKQNEQNELKNIKVGSFTKK", "length": 2531 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K45-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTKILYLIIYLTLTIVKGAPLYNCKKLNCSSMNTNCKVFGCSPMFGCFETSKCPQSNVDICHTNHCDENTGSCYQIADTCNDGNNNTIDSCGPYGCVNTPVNPPEPTQSCEQKCNDNNPCTVDFCDFRGDCYHYETRCSDYDACTLDTCGEKGCEYRPMNCDDNNPCTADFCSMLYGCYHEPIECSVKVPCRTDSQCNRNNFCETYSCDLSSNICDYYTRDCGGNPCINNECRTGTITN", "length": 239 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K50-1", "protein_name": "Phospholipase D Y", "gene_name": "pldY", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIINRLFIIIVLFFVNVNSKIISESTLNSCQGGTIQIAESIPLGLDISTNLSTHDAWMDLITNAQESIDLGFFYFTLLGGSDLDPVYGGQLGIDIFNAIVEAHSRGINVRIVQNEPSESFPDTETQTLAKLGIQVRSIDWVSLVGSGVLHTKLIIIDESSAYVGSANADWSSLAQVKELGIVLKNCPTMVADTEIAFQQYWNAADFTSLPINDWGSNYQALFNNTNMASLSLNNNNNNNNKNKNNDNDGSGTNQMYEMFLAVSPPQFQSTYRTGDIDALMDAINNADQSICITVMDYTPTTLYNDPNTYWPLIDNALRAAAFNRNVQVRMLISHWNYTSPIIPQWLHSLNQVDNIQVRWFVVPDFSTNPQIPYTRVNHAKFMVTEKQSYVGTSNWSQDYFTVTGGLSYNVFNNDFTNQLQSIFNRDWNSPYTQPIQNF", "length": 438 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K65-1", "protein_name": "Band 7 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSIKKLSTTAIKFTKQTQRFNKRGFFKILNQYERGVVFNFGKFHTVKEAGFHIVIPFIQKCDIVDIRTFTYTLDKQKIISKDNINLTVDALVVFRIHDPKLAVTKANDCILLVNEMAQIKVCEILSHNTLDQVLHNRDKISNQIHDELKEALNKYGVTIEYLKLKDIHFDETIAKAIAKKVEAANLRDIKN", "length": 192 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KF5-1", "protein_name": "Protein LEG1 homolog", "gene_name": "leg1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKSNKTIFLILLFLINFNSIYSFNFKKEIKISNDKINLPTYNPWIFQDRFNLYSILINSTNIPVFGEDNSNNCLHGLQLQFEWQNRSGRLEINQGHVNTKSWWGDMNYYLSIIPYLSAMKMGLVPVVEIVSINDQRFCSTYEDCDQEVLNNWDNFFQQIINIRNNGSEGDDQQLLKFMWTAHIGSIDKATKLFTDSLLLLPKNELRFGNGWAHFVDVIATVNFNTNYSTVYHLGQQLPPIMLNSNDTHPSSIESFTKEQRNVVLTMYEINDLSSNNLVWNSFMYLLKKMTKNEICRNLINNEINIFLNSPVPTIIEILFDILTNNC", "length": 326 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KK9-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTEVPNQKHNDGGVGVTVGNFVKDNETNVNNNNNINGKGENDNNNNNNNNTIIDEPKLLNNNNNNILVIPLTTNIIDNELNQQKQHTLPLPLPPPPLPTQPQQITPPLPTQTQLPNNMLPSPRPIQQPKIRQQTQQQQAQMQQLQLQIQQEIQLQLQQQQQQQLQLQQKQNESEINGLFSPNFSSSSSSSLSTTPNMHSPLFNNNNNNNTTTTTTTTTTTTNSSTNNTNSSTQTKNASTNKISQDVIGVFDDTDTESEGEEYHSGRSIDFWNKDYKDIAWRCNWIDLQIRDLQYQSMVCDQLYHKVRRSKQKIIPDNKSLSSSIDNNNNNNLKSIPIETIDHSNNAITSSNIPYSNNEEEQQEQQQHPSQSIRTTSVVKLRKPRKLIRRPTVKLSAKQMTTDLEAHPLFTFHKGYFKFENAIKTNIINEMEIKYQEKEKPPKLLTLSEERLKQYINSNEDVDVVNLFATNESKRLSEKRRGRIPSDKKEKVSSHRLKSGDEIDGTSSSTATATTATTTTTTTTTTTTTNKKSRRSRREKKKEKEREKQEKEKHIKTKDEQKDREKKEKAREKELEKERKREKERIKEKERQEKERLKKEKELEKNKKKEKKLLKEKEKEIKEKKVKLKNQENIIEKDLTINNTTTKTTKSKKSSSKVKKSEQEGVKLENVEIEDEEVEEEEEEEEEVEDEEEEEEEEEEEEEEEEEEIEEVEDNEEEKRKEERRRRRRKRRILRRRKKLRRKQRKRQLFLQKQQQQQLLQQQQQQQQQKLLQQLKKRDESNGLSYKEIITPEWRDISSFANNDPSLPSPLLLSNPLLAQDIKNITTTTTTITTSEPISKFSTITEEELLIRQTTNGIDGTPMNGIGEDSESSGSEIELDEDAMKIIHARNEIEEKRRFFNTIKQIQMENPVPSYKRKKESLPVEFVAPTVEELLPSYHFNKKSIKLLGKSWNGDFEYYSSSDEDDYDDSDDYDSDDDNDDEDDDDSDSDDEDESDSDDYDSEYDSDLSDSDDSESESSDNELDGLYSSESEINHNSSGDEDEMDVELNNHHIPSKNSKNSKKQPVNNNVNNSNNLNGSSGGGKINSKPSKQQPRNSKANPPSKQQPTPLKQQPTPLKQQPTPLKQTTTPSKATPSPKQQSQQQQQQQQQQQQQPQQPQQPQQQQQQSPKPTPPLVSTTPPLSSVPLSPPTKTIRSTRGVSSLSNSTSSLPKQTNTPPISILSRKRNQSQSSVTDAPLSPTTTATTTTSPKPTTRRKGKLQETIPVEETKIIEETKPFEETVPIKENSTTTPLKRTRRQTKQQLVNGETTTPLTNGDNHVEKTDSNSTDVKVDPTSWWGDKQYKIQPVMEATVIRFKRVKNDDGDDDDQIQNNQKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNINNTEDLESKIKETKSINIPMEISTNGNDFQMKEKEGE", "length": 1472 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KU3-1", "protein_name": "Probable polyketide synthase 25", "gene_name": "pks25", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDNSYLNNPQFDINNGNKEVTDDDNNKNNQDNLVAIVGVGFRLPSGENERNNTPQALWNNLINGFDGVVKTSERFNDNFFKNHEIANNYSGLLPLDEVKSFDPLFFGITPNEAQTIDPHQRLLLKCTWEALEDSLIDPISIKGTDTSVFIGSSTNDYLTLNRNEVKSNVFGSMAHSIANRVSYCYDLHGNSITLDTACSSSLNAIALGYDSIKNKKSKMSIVGGVNILLDPYPYKAFSILNMLSKSNGRCKSFDASADGFVRGECIGVVILKNLKDAIKDGNRIYCTINGASANVDGIGYSDKSNFYSPSSISQSENLKNAIQSTNGTVKPSDIDYVEAHGTGTPNGDPVETEGISKVFKDTRSTDTPLLIGSFKSNIGHCEAASGIASLIKCCLMYKNKCFAPNIHFKTPNPAIKFKEWNLKVVTEPIPFNENKNTSMIINNFGVTGSNCCLVLSQFNNTNKQKQQMKTKINNYLIPFSANSVESLKKYQSLIINSKENELKYSFEEFVKNQVFIKPTSLYQRSVIVAKDWNDFNNVENQVKYQTSSSTSSNITITNKNNNPITVFVFCGQGSQYNTMALELYKNEKVFRNSMDMLDNKMKNYFGYSILEKLRAIQDSDKRSVHEQTMAQPSTVIIQVSLYELYKHWGIKASFMLGHSLGEVTTAYCSGMIDIDQLCYLIYHRSTLQIRTNGLGKMLSINISSDEYKTNYMSRYPTIEIACYNSPSSIVIAGNEQILNEISKELKEKEIFSAMLGSLSSFHTSSQNIIKDDILNLNIQSSQPVIPTFSTVTSNLFNESTIFDSEYFFDNISKPVSFTQTISNLYKHIEDNQIGSNIVFIEIAPHPTLSFYLKQMIPKQSQYFRNGESISVYSTLHKKKNDVEEFQKSISQLFCDDAYDINFKCQFNNINSNIEAISNFNLPLYQWDDQHYWLNKSIEHKNNLIGPPISILGNSMQDSNPFIKSYQTIIDTGKDAFKYLKGHNVSDKCYFPGAGYIDNLLKLYPNQDLTINSIEFKTPLILSDDNGQFLQTNVYQTGKSDYRAQFHFKDNRTNVWVQTCTANFQLYNNGKVDKLNLEEIKSTKCNLSSIPWDKFYPHIKNRTGLNYKDKFQNTIECYLGDNCSLTEISLELPENFHDQESFFNTPILDICFHGSIVLIKDNCKLVLDKIDGFKLYTSNIPKNRFDHLSIFVYTTMKSTKSNSYNSTYTVMLEDGTVILEVENLICTSLTPVKDPLLIEIPTDMYYTPYLQSKDSQIQSPLEFKSIYQNNQDNDSLLIPNVVLETIKPLINEQMEFRILEFGGNNLSNSTLLLNSINSLLEENPHYEIDIEYTWSDNNSSILKDAKLELSKVDKGYLSILYRSLGLDVDNSLLEKQKLNPSYYDLIIVSNISNLTKDIKYSLNQIYQILTPNGNLIINEQQPNNENNENNEDSLKNLLVNCNFNSDIMMKSSSVSDSDIKSIIIQAQKPSLKLQPKTINTFDQVILYCNQDEQFQQQQQLINKFESHYNNNCKIIKVSTIEEFYKLSTTITNNSIIYFIKSIEQLTLENFKSITFEYVQINQKLYEFKSKCTHVLITYDSQSSNYLSSSILGAARYFDEIPTLQLFTFDFDKDSLINLDISVIDHLIDPKQNTLIEFFIKKNGKVYFERFKKGLKKNSFKSESYHQITNEQEILISKLDENLDYQLKSKDSILKPYDIEVEIKATGLNYKDYLVYSGLIKLKGDSVDFGLDFSGRVSRVGIKSSKEFKVGDEVYGIGQSTSSSHIIIDSMHACHKPSKITHVQAASIPAVYATSIHSLYNIGNLREGESILIHSGSGGVGLSALEILKSNNHSSPIFVTVGSEEKKQYLINTYGNLITGIYSTRDTNYQKQIKNKLIELGYETHGVDLIINTLSSEFMDSNFKCLNPEGRIVDLTITHLNPNEFIDNNKFKYNFGYHNIELYYCEKPTIKKLLQSISKSIENNTLNYLIPITEFSNSNIKKAIEYINERKHVGKIVISHDTDITNKLIENQPKIDYSLLKSNYKIKNLGKNVLVTGQTGLILDIINWIMKYNSTVENIIILSKSSMKWEMEFLINNNKTKIKFYYKRCDIGGDSDSINKTFDKLFTENPTITNIDSIFHFAVVQITRKVKDIDMKSLNISHDAKTIGAINLHNQSIKRDWKLSNFILASSILSKVGSLDQCGYVSACCVLDSFSKYRLSIGLPALSINIGAMGGSGMVARSELVETVLNGQGYNLTSTNQLLGTIDLLIQNPGQESNNLMVGNFNFPVFNNFKQKIHQKFDFIFNALDSNSENGDGSNIKNSTNIKDKFLNKVSEFLSIDSSKINNDIKLMNYGADSLITVQLKNWVDKEWSPNLITIHQIQSNSIGMVCQIINDNFEKKK", "length": 2380 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KU5-1", "protein_name": "Probable polyketide synthase 24", "gene_name": "pks24", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKQNKINKAEILQVDDKHVEENLVAIVGVGFRLPSGSIENERNNTPQTLWNNLINGFDGVVKTSERFNDNFFKNHEIANNYSGLLPLDEVKSFDPLFFGINPNEAPTIDPIQRLLLKCTWEALEDSLIDPISIKGTDTSVFIGCTESDYHNINKNEVKSNVFSSLNHAISNRISYCYDLHGNSITLDTACSSSLNAIALGYDSIKNKKSKMSIVGGVNILLDSYFFKAYSSLNILSKSNGRCKSFDASADGYVRSECIGVVVLKNLKDAIKDGNRIYCTINGASANVDGIGYSDKSNFYSPSSISQSENLKNAIQSTNGTVKPSDIDYVEAHGTGTPTGDPIEVEGISKVFKDTRSTDTPLLIGSFKSNIGHCEAASGIASLIKCCLMYKNKCFAPNIHFKTPNPAIKFKEWNLKVVTEPIPFNKFKNTSMVVNNFGATGSNCCLVLSQFNYNTINNNINNHNNNHNHNHNHNNIKINNYLIPFSANSVESLKKYQSLIIENKEYESQYSFEEFVKNQIYNKSTSLYQRSVIVAKDWNDFNNVENQVKYQTSSSTSSNITITNKNNNPITVFVFCGQGSQYNTMALELYKNEKVFRNSMDMLDNKMKNYFGYSILEKLRAIQDSDKCSVHEQTMAQPSTVIIQVSLYELYKHWGIKASFMLGHSLGEVTTAYCSGMIDIDQLCYLIYHRSTLQIRTNGSGKMLSINISSDEYKTNYMSRYPTIEIACYNSPSSIVIAGNEQILNEISKELKEKEIFSAMLGSLSSFHTSSQNIIKDDILNLNIQSSQPVIPTFSTVTSNLFNESTIFDSEYFFDNISKPVSFTQTISNLYKHIEDNQIGSNIVFIEIAPHPTLSFYLKQMIPKQSQYFRNGESISVYSTLHKKKNDVEEFQKSISQLFCDDAYDINFKCQFNNINSNIEAISNFNLPLYQWDDQHYWLNKSIEHKNNLIGPPISILGNSMQDSNPFIKSYQTIIDTGKDAFKYLKGHNVSDKCYFPGTGYIDNIFKLYPNQDLTINSIEFKVPFVLTDGIGQCLQTNVYQTGKSEYRAQFHLKDEMNNQWINTSNSNFHLNSNDNYHEEKQKLDIQDIKQTKCNLSSIPWDEFYSLMKTQLGANFYGIFSKVVECYIGDNCSLTEISLELPENFHDEQSFFNCPLIDACFHGTVILYIQKNCKIVTDKVEGLRYYASNIPKNRDEHSSIFIYSTLKSSPSDDLLSSSIVVMLEDGTVIIEVDNLVVKSLTPVKDPLLIETPSDFIYTPYLQSKDSQIQSPLEFKSIYQNNQVDDGLLIPNVVIETIKPLINRKMEFRILEFGGNNLSKSTLLLNEINSLLEENPHYEIDIEYTWSDNNSSILKDAKLELSKVDKGYLSILYRSLGLDVDNSLLEKQKLNPSYYDLIIVSNISNLTKDIEYSLNQIYQILTPNGYLIINEQQQQQQQQQQQQQQQQQQQQQLLNNENNKESLKNLLVNCNFNSDIMIKSSSISDSDIKSIIIQAQKPSLKLQPKTINTFDQVILYCYQDEQLQQQQLINKFENHYNNCKIIKVSTIEEFYKLSTTITNNSIIYFIKSIEQLTLENFKSVTFEYVQINQKLYELKSKCTHVLITCDSQSSNYLSSSVLGAARYFDEIPTLQLFTLDFDKDSLTNDLDLFKTIDYLINPKNNIQREFYIKNSGTVYFEMYKKELKNLKNSYKSESYHDLSKQQDQLVSKLDEHFEYQLNSKQIDLEPYEIEVKVKATGINYKDYLKYNEMIKVNEAGIGFDFSGVVSRVGIKSSKEFKVGDQVYGIAYETSSSHIIIDSLLACHKPSKITHVQAASIPAVYSTSLYCLYDVGNLRDEESVLIHSGSGGVGLSGLEILKSNNHSSPIFVTVGSEEKKQYLINTYGDLITGIYSTRDTNYQKQIKNKLIELGYETHGVDLIINTLSSEFMDTNFKCLNPKGRIVDLTTTHLNPNEFIDNSRYRYNIGYNSIEILKVGKSTIKKLLQSISKSIENETLNALIPITEFSNSNIKKSIESIKERKHVGKIVISHDTDIIDKLIEKESMIDYSILKSDYKIKNLGKNVLVTGQTGLILEVLKWITKYNSTVENIIILSKSSLKWELEFLMNYNNNNNNNNNNNKIKYHFKKCDISNWNLINKTIDQVLKDNPTITNIDSIFHFAALQINKKLKDIDMNSLNVSHSAKTFGAVNLHNLSIKRDWKIINFILASSVVSVLGSFDQCSYVSACCVVDSLSQYRKSIGLPSFTINIGGVSDRGYLSRHKLVEAVLGGQGVELISPNQLLGTLDLQIQNPNMPTNAFVNNFNWPLFKSFKQKLHQKFDFILNPINVDNSISMENDTNQSSSSTNVKNKFLNKVSELLSIDPSKINTNIKMINYGADSLITVQLKNWVDKEWSPHLITIQQIQSNSIGMVYQIINDSLDKKKKEMDEKLLPITAKTTTTTKNDPNDKTEYKYIAGGDCCREFSIKFHYSSVVNFII", "length": 2471 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54LI2-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "mcm2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQNNNNNNNNNNNNNNNNNNKRKTKTPSSVNHNNTKINEDKDLYNFIDKIRDKTDKSHLEDEYDEDDNTKDGKFNKVEDEIKNDIDSEEDDDDIIEDNEHLYDGDEDSENLSSEGEGDDLLDEDLQDQDEEEVLGDEDNHYEMEGLDNETYEDIDKDKKTEVDSILTKRDREEQKTRQATNRHQYRISSFLLDENDENMVDEDTENNKLLEKRKANLIKKRRETIRQQNDNIKKDYDGSVPSFKDGFVNSERYFEDGDGDDDDDDDDFDIGDNGQVVNLEEPDKDKCLREYVCMSGPRNEISKQFAKFLLEFKEKDGFNPIYQESIQKMCAANKESLMINFTHLCASTVFGVWVAEIPTEMIEIFDEVALKVVLRIYPNYRNIVKSIHVRITHLPICESLRDIRQSNLNKLTKVGGVITRRSNVYPQLKHVKYDCVKCKTTLGPFSLDGTFNDSKPPIGLCPQCQSKGPFVMNSEQTVYRDFQKVTLQESPGTVPPGRLPRTKDIILMDDLIDTVRPGEEVEITGIYKHNFDLKLNYSQGFPVFSTIIEANHINKKEDLLSSFILTDEDEREIRKLSKDSNIAQKIIQSIAPSIYGHEDIKTGLALALFGGTPKDVNNKHRIRGDINVLLIGDPGVAKSQFLKYVEKTAHRAVYTTGQGASAVGLTAAVRMDPLTREWTLEGGALVLADRGVCMIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLTARCSVIAAANPKRGKYDSGLNLLQNVELTEPILSRFDIICVVKDTIDSFKDRELARFVVASHINSHPDNQNNPENDYLNRATKQSPISQELLRKYIIYAKRIKPRITDIDKNKISQLYTDLRRESRAGGFAMTVRHVESIVRMAEAHAKMHLRDYVTDFDVNTSIRVMLDSFINAQKNSMYKNLRTKFAPYVIFQKDINQLLTQLLQTLARDFSNYHFARSGDIPDQINIPYDDFDTKARELGISDITSFFRSNEFTSNNQFTLKKDKSTIIYYRNK", "length": 1008 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54LX5-1", "protein_name": "U1-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKITESNNNNNNNKKDNNKHWCKYCKIFIQDNISVKNHEEGWRHKNNVTRFVSTQNRDKKYQERDQKEAEREINRIKNTGARSFREKDLSRVLDEKKHQQQPQQQPQQPQQQQRIFNNNSNNNNNNNNNNNNNNNNNNNNNNNSNNNNNYHQPQYPTTTTTTTTTNTTASNKNCDNADSKFKEIQEQQRQLLSNNDYYNYYQDRQQLIYDYYQNEGNQPIPEPPLNTSLYGYTESPLLKSRLDSSTDTLSSSSSSTIISPSHQKKRKQDDTNSPIPAKISKDECVNNENKDKSNEKENELNNNNNNNKSGEGEEGEESDDNDDDEEESGSGSESESESSEVDQSESIIGQWQTVDPIESAFGSTRKDSDDEKDKKDKKNKKDNDENKRDEKDYSDVSDADSEEESVNITKRAMANHKKPITLTNVISPTIPSTSKNFESVLSFNKSGVFSLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEPPQPTPQITLKFNKPLKQRNTRKTNIEDKQS", "length": 514 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54M95-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLISILFFLFGILFFLKNVESASDVVCSFGYQACGNNCYSPSSGQKCYPGGVVCSFGYEACGNNCYSPSSGQKCNPGGVICSFGYQACGNSCYSPSSGQKCYPGGIICSFGYEACGRSCYSPSSGQKCYPGGVICSFGYQACGNTCYNPSAGQRCFN", "length": 158 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54N59-1", "protein_name": "G domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDLDYAIIVLRHHLESNGRFFEISKDDVKNRVTIKNKLTQEERYIDFGEIQNFIQYDEFEYNLLANGFQENLSILKNSILPLTKAPDSCSSNRGKTIGNSSLLINKVNGLIDDDKDTIYLLLIGITGVGKSTFVNMVVNYIEYSNLKDALENATLEQIYTIASKIEIQDENKTHKFSLGDVEDYKIGSSVTQYSRQYRIKLPDGKTLCLIDAPGVGDPQGTLQDNKHFENILHEISSLKKLNAICILMRPDETRATVLFKYCLNQLLLHLHSSAKDNIFFCFTHTRGTMYKPGPTRAILEDHLKKMKDQSDIEINANEKTFCFDNESFNYLAVKKYNATAGIETNFSEDDEFDFGRSWDRSSKEFKRLLEEISKVQPHDVANTICINNARTMISNLAQPMSTCISNINTNIKLMEQQSEKLRNNSIGDESLLYIPVSVVIAEKLENSLLVCTKNGCSSNTDNPCNIDVVSPKWYSSLYWCDNINKMGTCKKCSNTGVLPCLWFDHQVVTIKETPQLNQLPGTDKKTIGQRTKSEIFNERELLVTKMGERKIQFQEEYDTIKTAIVDFSVFLWHHSLIKFNRYYEDYINMQIKQLENSENSQELIQKLNEHLSEYKASVEEIKHNVQNNKASVKTQKEIFATFDKLLTLPNVGYIIQNQIKLKQSSHYKSEAVEIDLFSKMKNKTKQIIK", "length": 689 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ND5-1", "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "mipp1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMVKIKNIIILFCIFGLLSNVSSLSSSSSSSQSSDNNGNLSPIQDYDLEFLSKHLTTKTPYWILTKNGDSNSQGDGSSGNSNSNSNSNSNSNSNSDSSNEPPEQCKLISIDFIARHGSRMPVLNSIEKLKEMTTSILEYKEQVNQGFNWIFNYSVPYPSDIAGNLILQGQYEHYNISKRLLKKYPLFFEPMKYKPQSYSITSTAISRTGISASAFSYGLLQGTGSLGVDGFQPVFIETASLDQDILLRFFATCNQYVDQLKNGTLINKDEQTKWNQMVFPNISNEISERLGLSDIWLPTSNVISDIFEACAYEISINNISDHWCSLLSKQNILDWEYSQDLSNYWLKSYGHEINYQIATPLLNDILSGFDIYINNNNNGSSSSSSSSSSNNGDNSGSNGSSGSGSSTSTSSNDNGSTNNNDNKVEPTSILRFGHAETIIPFISLLGLYKDEQKLFANSSTEQIENRKFRTSVVSPYASNIAMFLFDCGSAADGFKILVQHNELPVLVPGCDEIYCDYQQFKSIFKQGIDNFKWNSYCNINDDDSGSSGGDSGNGNGNDSHSKKSSYFLAIFIPITFLVGGTIGGIFTYFSYEKIMQVKNRKKLTQYGNDEFISSPKSKSFSFKPTKFDSRSPLIQ", "length": 635 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54NT2-1", "protein_name": "SH3 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNKITTQFARTRQMLFTKTGHSEETIDVQYHYEKERTFSTEERLVKIQKNSKKLIELYKDLNKITTDIAQDACDLYDTQDPMWTPGSKLRDVATNNDKHLLDYTEQMAEPYTKPLSDYISQYKEARKRTEELTTRKVDMDRYKNEVGKLREKGAGSSSKAKLAPTEEKLRICKEGYDSLHEELLNDLPRLNEDKLIFIDYLVASLIKYQSEFHKKVSYEWSPLPSLTKHVDEYSGRDHQPVITSVERSAASINLRSDPVFKSNASIKMKPGAQDQQQYSTVDKDIHQSPNPSNLNLQKSTPNPYGGASAPPPLYGGGGSSTATALYDFTGVDSSELSFRAGDIITIHKSEGEWWEGELNGIYGFAPGSYLRMN", "length": 374 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54PW0-1", "protein_name": "Annexin I", "gene_name": "nxnB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEYKEKEINTSSPSSPSKTQISNIENDSISEKAQEPISEKVQDPISEKAQESISEKEHIESNNVSEIIDLIKSGDQHLNNNNNNNNNNNNNNNNNNNEEENQEINYNDNQLSNEEIVEDVKNSNINNNNTIEKGNSSQNNNKNNNNNYHTEKCDYCLICKCYDYGEITHNIVEDSEILKQSIRYSYVDDTSINSILAHRNYAEKEAIMKKFNDKYNKSLETELASHTHQKYRRTLISILTEPSIYDTLNIENSIKTKNSNTLLEILLTRTNEQKELIKRIYLVKYGKNIEHDIIAKFSNGANVNGNMMKQLLISMLNNDRDSNSNQSLDMNLINTDSNRLYQAGEHKKGTDHEVFIEILSKRSFSHLSELDRVYENSNPKGHSLRKAIELEFGVSKSIKQVKISLLDILLFSKEPSKYWAEQFNRALTSGSWGINEIDLTRLTITQQHQASKIKQAYISHYDNSLINEVSSKTSFRYKKIILSMLTV", "length": 487 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54QB4-1", "protein_name": "Kinetochore protein Ndc80", "gene_name": "ndc80", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MHNNNLTYQQYQQQQLLIQQQQQQLLYQQQLLQQQQQQQQQQQQQKQYSHGRPSTLGLPSRKPPPMQPQPQPQIQAPIQLTFQQQQQLLQQQQYQFNNNLNTINNNNNNNITNRHSMVTPSTNLGGRSSLGPPSAMLTNNNNNNSNIRNTTFISNSGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNNNNNIHTQVQPKKSIAPSKSNTISSNTTTTTTAASSSSSSNPSITLRQETRPVNDSKFQSQCLLRLQQFLSQSEKGYPRAITKDNLMSEINGLMKFLCLHIDPHFKLPTEKPEEEIISFFKMMGYRSAGFTKRVFSQVGNAHTRGHLLGAIIWMVELIEYDQIIRQMDSHIEREILNGNTIDENGNLTTTTSATNTNEDGNFNLTTQIFSKHVFKSYEAFLKGDDGNHVDQFLEEKFNEVNELIVKECEESMERQKKIKQEIVNLTQYITNDDIDQLNFKLEQTNQEIIATHDLINDNELEDQKLDQEIDQNQTHFQELEIQQKEHQKKKQEFESRIQIQQSNSVDAKRINQETFELKEELDKVQREQSRHDQLKQEKSKEIKQSINEIEKLIQSYKEICCKASLVTNDNLIIEKYRIIFTHTLNNNNNNNNTNNSSILNISNNIINNNNNNNNNNNNNYEEGIISISDLKLVIKNLQELNLEISQNISKIKQDLLKTSNLNDIQKESISDKELELARIKQKHDKQKNILKQEKQDQTFDITQREENIEQLKSSNKKLIDDGVRELEKTIQLLESQREEHSRLKIDLKQSSEQMKLQYLKRIERFISHRQLIGSQIFDTLRQMEELSLTQKILFPPPPPPPQLSQQHQQLMQQQHQNNTIDIDE", "length": 855 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54QD2-1", "protein_name": "Probable cytochrome P450 517A1", "gene_name": "cyp517A1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIINVFLFLIILFLVKDFVKKNKKIHTKSPSGPIAFPILGNVVQIRFWELFKIQEHELFGGYSKKYNGVVRAWFGERLFFFVSNYDVVKYFQKDENFHNRPSVLVPGWRYASSNGLGVMSSSDDKWKRAKSSVSQSLRVRTTKKLMEEKAIEFIDSLEKISNNNEIFYPKGHIQGYACSMLFKYMFNQDLSVESGMSRTIGNAVEHVFGNLSKLTAFDCFEIFSPLYDWFFTRRLKGCDIVRQIISSQNENHLKSIDPSKPRDLMDDLLIEYGLNEITKEDTMQINQICFDIFGPAVGTVTITMNWVILQLCNRPELQEIAYQEIKKAVKDDEYVNLNHKQNAPYIVAFIKETMRLCSNGFGLPRTAKNDQICGDFFIPKDAIIFINYLEISQNEEIFKNAKEFNPTRYLDESLPVPNIHFGVGQRACPGRFVAIDKMFLGISNLLLKYKLKTQNGEKIDDSIQFSVSLKAKDYGIKLEKRI", "length": 483 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54RM4-1", "protein_name": "Peptidase S8 and S53 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKVILIYFIVIYLINISFSLKPYQQQQQLHNFNIIENNNNNNRNEKVIIAHPKIPPYWLIENEISNPNDLISFKILLKQNNLNKLNYLFEEISDPKSKIYGEFLSINEINELVKSSESDFNVVLEYLKSFNIGNIENGSEIKVFSDYILVETTIEKVSSMFNSKFSNYKNKNNGNTRNRLNGPAYLPKQLLNSIDFVTGLSEFFENNFKIENYLNNNNKNNGDSDSDSGSGSGSGSSNSYNGGLDDILITPKVLKSYYNVPNELIGKFENNSIGVIAFNDYFSMGALELFDEKFNITTTKDNLKIIGNDCLGKGCDQYESDLDIQYIRSMGENISTDFISFNDAQWILDYLHSVLLMEKPPLVQSISYGWAELLQCDVSNGCSTFGYDSKQYVDRTNSEFQKLALLGISVLVSSGDDGAPSMGGSSGNCPIDGTVYCPTGGCNHTKTMCPEFTIYNLNGGSDSGGSSDSYCFFPMGIASSGCTNILGDPSVLDSGMKIFSEKNKQCNLAIEYDRTNLPHVYSECECKDLVNVTFRNYHFTQYQFNENNGALFVAEYPSSSPFVTSVGATQFLSRDEKITTEVGCTILQGAKITTGGGFSSFQSQPKYQQYAISQFFNTSFNSLPPSFSYCPTNRGVPDISMVGHNYKIYSSDGNNKDFNQCPCKSLPVDGTSCSSPTLAGLIGLINDQLLLNGKTQLGFLNPLLYQMAIDEPRIFNDITGDSSNRCSRSYCCLYGWSTSSNTWDPVTGLGSIDFNLFLSYVLKLKGI", "length": 767 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54RX1-1", "protein_name": "Translationally-controlled tumor protein homolog 2", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLYKDLIGNSHDDLLTDRYEIKVGDVTFEVKTKMITKDLNVVVNNNSLGGSISTTVDNNNSITLSTNLEDEFENVEAAGTFQINNLVEQLRLVETSFDKKSYLAYMKLYIKDLINHIKQQPSNSDNEKIEHIQKGIQSFVKTMMDGENFKKYSFFTGSSMDANGLVALMYYKDDDPTTPTFVFIKYGLLQVDV", "length": 194 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54S19-1", "protein_name": "PHD zinc finger-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKNCIVCSKVGQYPLNLVKCYECKSYYHKFCLQSTKIPRGEWYCSSCEIERKNKKNKKRKLDGAGKKNKKNNKDDDDDNDDDDDEGENDEDDEDHQDEDSGEEEDEEEDEEEEDDDDEEEEEGNEKNKIKKRKRIPINQSPSIKKRTKDIDSEEEEEEEEEEEENDSEEERRIQKRKNKIKQQQQLKMKEKKQREKLRKRRRRTRSSRKDDNDQDDDDDDDDNNSNNSDDNDQDENKNKQKRKRRKDKKKDDDDDDDQEEEEEEEEEIVTGKRKRRSLNKVQPNQHLNNENEEDNEEEEEEEEEEEEEEETDSSEEFLENLVCSSCNTGKDEDKILLCDTDNCSRGYHMYCLRYPITSVPKGDWICDFCRFGDISADLHSADDDEDGAINSQKEIEKQKQKQKEKEKEREREREREKEKEKERERERERREKEKKDALRSSFSNIPIPKINNINGSNGSNSNNNNNSNNNGSGVNRQSPPKVISKKSPQQSPKPLKSPTSSSSSTTSSPPPLHQQSKVTSKISPNSQQSIPTINSNINKSPPSQSKNSPPLKPLTPDLKKQIPITNITTSSTTTTATTTTTTTTTANTSNVATTTTLLKPSSQKKPTILSDKKQLNTSGTNLPMNGKKKEDLESSASHSILDMIPPNNKLFNNSIQSAPISWDLSGSQHKLSTSSSSLPNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIKLQQQLQQQQQQLHQQLQQQQLQQQQQQLHQQLQQQKLKQKQIEEEQEKEREQKRLENEQKLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEFIDQKELEDKLLSQFDNQNLKSPLSLTSTTSSTLSHLPQSTFESSTILSNKTIKQKWKSRILFETDQICQCEIIQIYGMDFKVNPFQNNITSKTLELSFNQVSFDNLPKPIRDEFITKSSTPSTCLDIGAIDLPNSALLIFLPEIPNQSSLYHLIIHFIENRVAGFIDLSNDLSLYIYPYQTSIISLDLIGILIDKKSLSPPSLILNQQQKQQKQQQQEQEQQNQSFDIKNICYIGINHISMNKILTSQGKNYFSFSNFNELTLSSDIKNFDLVVVDNKMVNNQTINKEINNLMQLQPTTNNNNNNNDINNNHDTLLLVIKDVEFSKWLVSQKKFPNSLEIQKIFQQQILFKQSRCIFLLDNSIIIENESSYFVEFISSFGKFKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSNDWTIKISSTIFDELLPFGHQSNVKKKIDEIKRGINQQLIVSYDFSPMVPKQSSDFLLLALRIAHSKKYKQVFLITSNKIIQNQSKRYSNLNLNCLSLEGGIDYIKNINNKFSLKI", "length": 1361 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54S56-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDLFSHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVGECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54SW0-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "NQAKSSTIQQPTQTQQSNINNNTAKPRAAPPLKLVITNSNPSLKQKPQSQQTIPQQSVPQQSIPQQTIQQSVPQQQPNQSQQVNVNRTINPQQQQQQQQQQQQQQQQQNINRTAPLPQQSNYKPQPGVIYQQQQQTQYRVGTPLTINRSPMVGMVSKQPMSSSQQQSQSQQNIQRVPCQGKCCAGLAVKPLVPINSITAKPPPYSTMGPRGPISGGFVRTSPTGAIIGPSPQQQTMSRAMVNSMPIQPQIQIKPKPSPLNNGGIPITTTTTTTTNPLNKSSPSTLTQSSNTLASSNNNITTSNSLSSSTSSLPTTSTTPTTKPKSKPRSKSNSNSQTSSSTTSSSSTPSTPTTNSTKNKENTTPNKGDDSGTDNEKSSLSNSSKLLPTAYTMDQVLPFNPNQMFLGPEDKYIKSATRTYHKIPTNPSVMSNNRGAEIPSSLEYILDIPIIHDEPSSKNNPTWGRLILDALRRLVANKKTTRITERLKLDNMYKDMDSRSNQDKLDWKNGLVNEAQLNYLLSFLSNTIPFPDTPEKNKNKYLSSSDSQIINSNDQSNSLNSNNSSNNSTTNNNNSSTTTNSTNNIINNNNNNNTSSVPNSTNNSNNSSPEQQDVIDMELKLEPDNSMNFPIEINMDSLGSYIDDSFTFDNSSYDDTATISSDDKNLPITTVMPPTTSTTSTPQTITNTIPTTTPTIISPPTITTTTTTTKTTSPPTITTTTSPPTITTTTSPPTITTTTTTINSITPTTSTSSTINSNTTPMLDIVIDPVISLELLDENHQQQQNKEVKEENVHSKQQPPQQQQQQQQQQQQQQQQQQQQQQQQQQQQEDFMIQVQTSDLETQTQIQQDKEEIQVKPIVDSKKSGNSPTQIQQQQQHQQQQHHHQHNTLTQGFEFGMMMDIMNSPSSTSSMKRKRDDVDQPINQINNSSMVVQQNNDFFSDFNTIEAPFSSSHHSSQLSFQTPFSPDIVIDSDFQNKKRIVS", "length": 981 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54T36-1", "protein_name": "Probable polyketide synthase 19", "gene_name": "pks19", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEFGNKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSITMGFQSIQNGTSNLSIVGGASLLLDPYVSKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSTTSTPSKPLLIGSLKSNIGHCEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNINEKPVSMVINNFGVTGSNCCLILSQFIEHSISLNGNNPSYPIESQQQIFLIPFSANSVKSLKNYEDLIINDNNLSTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTSNDKSSNITIKRNQPLIVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLDLKENNIFCAFLGSLSSFHTSSQNSTKNEILPLEIPSRQSTIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDINFKCQFNHNDDDVNSIRNNSTIILPNYQFDEQYYWKVDINFEQYRLNGPNVFNNLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNKDIVINNLEFLAPFVLKENVKHILQTNVYQLGNTDYRVTFNIKDNKANQWVQTCTGNFQLISLKDNNNNNNNNHSSKYNINQLLSECNFTTLSKQEVYKYSKLRSGITHLGTFQGIEEFHFGNDLTIARIQINYENFDINGKPVYQTFDKSFFNIALLDNCIQAITGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLEADSYKSSVLVLLEDGTKLLEIEHISFRSTLPLIDELLLNNPTNELFTNNLQCKDSLVNILSIDNNETSSSSGSSNTVTEIIKQTIKPIINEKIVFRILQSFSDSELSKQIIEALNQIFDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDETIIKPIFNILSSNGLLLLIIEDDIGIRFNINNLIGVGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKHSKYTNEFKKLISNNHTNRKQTTISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGASRYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNEIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISDENKNCEFKVGDNVFGVSHDATASHVITDVLYVSHKPNNISHIEAASLPIIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIEFMHINKRVVSRLLKSISNALNENKVKLIPITTFQIENVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKIVDVGDSIEMRKSINQILLENPNIDNIDSIFHYAFTQVTKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCTYVSANLVLDSLSRYRKSIGLPSTCTNWGTIKSSGFVSRNDSVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKYSNLIVSKFNYDSIKKFASETSTFQRLDFILNSIKEKDNDNNGGENISISESIQMKFLNKISELLSIEQSKINTDIRLGEYGADSLTSVQLKNFIDKENKSNVITLQQLQNNTIGVNIQIILEQIKKLDSNETKGKSKKIIKKDSAPSLEYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKVKVIVGNLASPLLGLSKLDFGFVSNQINLIINSGADINLASNYEESKVVNIGGLIELIKLSTTGDYQKPIVGFSSISVFFESPNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLFREAAKRGIPSMLIRLPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPNIDKNILTSPIGWIGLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSSIKSSFSFLEKQYGCEMVEYEQWKNIINQSKILSCIKFKTFHSLDRLNGVYNLGHGFGVSKKTKELLQSMNSYEGGMVNEKIIQNHINYIFKN", "length": 2778 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54TD0-1", "protein_name": "Peptidase S8 and S53 domain-containing protein", "gene_name": "V4-7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISKTSLLLLLLSIVALASAISVQRVPIADVTSAPAHFVQNKLAKSYELVQFKILLKQRNLDILEEKFWDVSSPKSENYGKFLSKEEIDSIVAPSPKDVKVVVNWLIDNGLSKNEMIVHSDFIQVRTNVGKASTLFETSFAHYSSSRTALKRIRVVGQASMPMHVLAKVDLVLGLSDFIEDNKMSESMRATKKQVQGSTVSITPAVIKQYYGIPTGQIGVESENFQSIAAFSDFYSSGALQFFDQKFGIDSSTVRVKNVGQNCIAQNCDQMESDLDVQYMTAIGNNITTLFLSSGNGEWIIDWATAIQQYNPIPKIASISYGWAEVEQCEITNSCSTLGIDSVVYVARSNVELQKVGLRGVSVFVSSGDDGAPSFGAASGNCPIDGTKQYCPLGGCNHKSSQCPMITIMESNGTQCFFPMGSESNTCQSMLQNQNIVNGINEFVSSNSKCQVALEQDTQQNYHIYSSCTCDKLKPYSDSDAGFKIVGYSYDQDAGTLFQPDYPASSPFITSVGATQITDVTKPEIVCSVATGAIITGGGGVAITQAQPSYQADAVATYIKSGTLPPSYSYNATNRFYPDLTLVGHAYEIAVPNTLTSNTCPCALESVDGTSCSSPTLAGMISLINDKLIGAGKPTLGFLNPLLYQAAKEQPNVFNDITTGANNCNRAYCCQYGYTATTGYDAASGLGSINFKNFEQYVLSLN", "length": 702 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54TX3-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNFERIDHGSGKGTGIAIENRDTRKGHISINFKDDDGRILSIKYNSFNSINILLIYAPATISERNTFIINSKSLFKKYNSINHQIIAGDFNNNHDCNSFFGTELRKIIDQDMLLDTGIEENTPTFPRSMKRLDRIYCHPTLLNQNSKLVVHNTVFNKSDHFPITITIQTNRETTTTTTTKLERLPWTLCKEILNNKHIHDGLSELISKNKDKIKSVEEWTKFKNNVIRDYFKKEQNKIKKEKNKRKYVIHKLLGNSDIIPKMRKELNEEISRILEEERKVKAWDIKLKLHLHQETPSKYLTSILKSRAKDKSIFQIKDKDNKTISDKENIAKRFVEFYQDQYEEKEDNEETHKKLLEKWEVDVDLIKKLEIDRPIRIHEVTKAIKTSSIHKSPGLDGINALFYKYHINSIARILTIAFNDLLTNKKEIPTKFKEGVITTIFKKGDELNISNRRPITLLNTDYKILSKILNSRLLDITSKIINKFQNGFVPNRFIQDNIQIMKEVIEISNKRKNNTLITFYDFNKAFDSISHKSITRTLEHIGIPPKFTAILLNLLKDTKNKIKINDFLVNGITIRTGTKQGDPISPTIFALVLEPLLIDIINDNTIKGFTLPNSKSLKLTAFADDIATFTNSTEELMKINTKIQKYCSATSSSLNKEKTVMIAIGDKPHDLPFQESTVPERYLGLNFTKTGLNSKYNTLIQEMKNNLIKWKSQAITMKAKMTILKTYVLSKLTYHQYMDNLNEEQIEEINNMTRWFLFSSVKNTYTEERKYKTMMKIDRAYADWKEGGIKLWDIELRHIAFKIWYMNRLLHNNYNNNNNTLQEWYMEQLSRKKAHTSTLNDMCRHWGVFRVKFYQNHPKINELPDCIRNDNDEPLKLKEIYELMIKDRHPTPRRTEWQKLWAVRYNTAIPKVFININSISHQKGRNTLFRFFSRSLPGINHERDTRCKICGHLFRDPYSHLFTLCQDILDIEKTIISTVNKLSFIKIHRWSMDTLDISKYNRTERIFPNLIGIIAHQLWKIICHKLFNTDESKPEPKFEQKVIETELLNLIETEKFITLKKIKHDEAILKNTNQDLHKYKFNKAWQTPAAPNPLPI", "length": 1097 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54U20-1", "protein_name": "Peptidase S54 rhomboid domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIYGDTREFRNIHFHLNNIRIVGAIFGQDGFIHKKIPLATKVISIICSILFALSLVAPSMFGSYKTCLSIESLTNSFLDNLYRIILSNFAHLSIYHIVYNMITFLDLAKLERLTFGTLKYFYLLFLFGIITNLICLFIYFIGRNNVCHLGFSGVLFALIYIESNSSGRDVFLFNAVKIPSKLYPWAMLILAHVFVPRSSFIGHFSGIVVGILFIKGYLDIFILSNQKLSEIESSQLMNIFTTKNSYFPIIKFGGSRRSYNTDRKSLDGLFFELKNLFNPQQQQQRQQQRQQQQPQSPQPQQPQQPQQQPQQQPQQQPQQHQRDNFRNDNNDNSNNYDEYDFSK", "length": 343 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54VC1-1", "protein_name": "ABC transporter C family member 15", "gene_name": "abcC15", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKKIKNIINKIINFFSTIYILCKIYLYYNIKNRYEAYNILSVYGDDDFFNKPCPEDSSNWKDKLTFKWVERIIFVGFFRAPLNLNDISDLPSSLKVENTAPLLKDIIFNDSTIPLIKHIYSKFLPRNYIATGLFVFVSVFSFITPLILKNFLSYVEKIDEQKHIYIGIIQCFLLFLSSFINMASQQYSYWFGFKTSLEVKGALETIIFEKMTKLSNLSKKNYNIGSMLNLMSVDTDFFQYFFCHYYIEIFLFPIQILSLLGFLIYVIGIAGFVGFLVMLITIPLSSFLGTQISKNLSTSMGYADTRISLTGELINGIKFLKQYAWEKMFCERIEEQRKLQLKYLYIRIIYWVLVQIVTQASSGLVLVSTFTTYTLLGYEVSLEIAFTSITILQNLRRPIESLPDCLHKFISLIASAKRIETFLQSSELQNQPFIHNQSGLNDILIRNINFNWNEHNLKLKNNKNNQNNNQNKRSIILSSGEQFEITNDFTFDGIDIQDDNYDYEKEYKINYNNNEEEENFMTDCLLKIKPLIKDRRLQQQQADYQDLLSINLPPPPSENVDFKAPKGLLTIISGGVRSGKTSLASGLLGEICKAVDKSSPDSVNSILSTIQQPFLQSTSFRENILFGKPMNMERYIKVIEACCLAPDLLAMGEGKDLTEIGERGINLSNGLKHRIQLARALYADSDCYILDEILSSVDPEIANYIFQHCIKGMMKGKTVILVTHQIQFISSADHVVVVDNGVLIQGTYLELLRMGIDFEMILKEKENRIEKQIVQLQEDEDYYEEVEILDFTMNNNNNNNNNNNNNNSNFNGNNKLKRSSISLPKGISIESIISKDFDQTTIEKAKLFVQEDRNKGDPGWIIYKKYIRMGSSISFFIFTCIIYLTSQIILLLSDYWLQSWASHDRLNVSEPTDVHYLLIYLAYIGGFVFTLGVRYLLIAKITFGSAETLHRSLLKSIIRAPLTFFEQNPVGRILNRFGKDISDIDILLLDCFSDVLYCGACLVTSIGIIIYISPYIAIPFVILIAINYIFQLFYNYSVLELKRIQSISRSPVYSLLSEVYNGLTTIRSFGQQERFFNMMKDNININLRVFFYNFAVSRWIGIRVEFLSAIVVLMSALFSIFNDNPGLSALGVTTALGITFNLNWFMRQFGELESRINSVERVQSYISIPKEKETNEDEFIQTGFIWPSRGEIEFKNVEIRYRPNSIATLRNFSMKINAQERIGIIGRSGSGKSTIGMSLFRMIECSSGSILIDGDDISQIDLKRLRSSIGIVPQDPFIFSGSIRLNLDPFDQFTDNEIWEALSKVKLKKMVSTMPMKLESLVQGGDGLTIGNKQLLCLCRAILRNSKIVLFDEATNSIDFQTTRLIKQTIEENFKDCTILTIAHNIDTILDSDKIAIIDEGELIEFDTPLNLIKDSTSRFSKLIKLNNNQKNKLN", "length": 1436 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54VG9-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKSIIILSFILSIISFSNGTIVKCTSASCSSLNNNCVNHYCNPRAGCYGIDKCVRIDACHIVSCDLNNGSCINTKANCDDGDPCTDDFCHNGYGCFSLPNNKHPSVICQKNCNDNNPCTDDFCDFTNTCQHTLKNCEDNDFCTIDSCGPNGCVHTNISCDDNDPCTSDFCSIMYGCYHEQIECSIKVPCSTDIECNRYNLCETYTCDLISNICKYSTKFCNGFPCINNECMTGVIYN", "length": 237 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WA9-1", "protein_name": "Short-chain dehydrogenase/reductase family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIKKNIFFITGCSGIGFGGLMVKKLLSRGDYVAATSRNKNKLIQDIGSNENDQFLPIEMNLADESNVKEAIEKCIEKFGRIDILISNAAMGILAPLEETTDKDARTLFDINFFGPLNLIRNSLPYLRNNQFLKNNNDNNNSKLNGPRIIIIDSICGYSSLFNGCSIYCSSKFALHAISETMSIELKPFNIHCCNIAPGYFQTSFLSSCLIPDTRIAEYKDTHSFLDEIVKLNGSRFLGDLSKAVDVIIEISLSYSPPNHVLVGSDAFELFDLKYKKLTNDILINKEICSNTDKN", "length": 295 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WC3-1", "protein_name": "Cln5-like protein 2", "gene_name": "cln5lb", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKLIFIIICLGIVDKTISSDFKSYNDGIYSFTYDNICSFKNSIRDQDVYELYYVQAPLLYATYGNLLEKINAYHSGIVLYNKNNGPNITIDYYAIPSFEATLFPKSIIKDSQGNYNITWDTHGLIEVTNYINETYWNKRQLIMYDLSGIQIKQYLSWAPIYNKTHTFYNLFNIESDLSISNSSKIYKNSSTCDDFVWASFDVLYKLGGTIASVQSDPQRDDIKLFISSGEPKIVDYNDSIKRNQIASFFNELKDFANLGKNKTALEIFNELITFFNGYFYCYIDGEYYEMKLSKQNPISFTYLPSPIPIGKRNFNEIKKLGFCK", "length": 325 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WW7-1", "protein_name": "Probable serine/threonine-protein kinase DDB_G0279405", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGCIFTKPSPEQQKFDGEDYECENKKNLNLISYIRNLLFGNNSHQQLYNEIIPTTTSTTSTTTNSVYQNIGLDGYNNNNNNNNNNNNNNNIMNNYGYDDYGYSYEEDEDYYDEMPIPTIVAQPQPQPQPQPQPQPQPQQPIRIVSQNQQIPTTPPQQISQFNITGNKSPSSIGSRHRSKPKETLRAHKKRHKDGHKMVNEYVFVRKLGKGTFGKVKLAYHHDTHHLYAIKIFNKIRLKKQTMGIGRPNAFDDVLKEIAIMKKMNHINVVKLYEVINDPQEEYIYIVMEYIEGGSIMSANETSEDLARKYFRDIVFGLEYLHEQKVIHKDLKPENLLVNSEGVVKITDFGVSHIFDDDDVVRCSRGSPAFLAPELCRNESQPISGKGVDVWALGVSLYCLIFARTPFISKTNSLLDIYDQIVNHEPTYPREISNDLMDLFKRLLDKNPLTRIQIAEIKSHKWTTISGTWPMNELDHLILSVTDQEMIDAISTDHTIKPSDNTTTDEDDSDLSSSSGGESSGIIGSSNESKSMYNNVNSKQKIQNQNQNQNQNQNQNQNQNQNQNHNQNQNQNQNQNNNNNSLIEKSNISIPASSSSISNNDSCYENRNVYIKDEEMNMICNDSVIMDPIKELNKIDGLNYGCDFQIGKEYSDFQYNSGHFIYDLVDENESQISRESANDYYLPFKTNKYLNNKSIV", "length": 695 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WX7-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MARTDNVQLPLENTSIEFEEEIIDSQNDISQQKNYQDFLKNIPTDLNERKEYISSLKKLIKLEKRNHQQIQGEQPNQQEGLNSDRPPPNHHGDHHHSLPPPNHHGDHHHHSQPPPNHHGDHHHHSPPPPHHHGGHHHCPPPHHGGHHHCPPPPPHHHGGHHHHCPPPPHHHGGHHHHCPPPPPPHHHSHHHHCPPPPPPHHHGGHHHHTPPHPPPHHHGGHHHHCPPSPHHHGGHHHHSPPPPPPHHHGGHHHHCPPPPHDGNEYLPQSQTNIEQCICRLNRKKELLIAKIQSIDSIIYNLECLNKQNYQNNYLPSIQLQPTQQPQQPQQTSIKPQQMCQQFFIPQTPNFPQMNNSAPLMYVSQIPVQQSFNNN", "length": 374 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54Y59-1", "protein_name": "Small GTPase", "gene_name": "rsmH", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNIFLSKSKDVYRVTSHKKEVKICVLGDANVGKTNFINQFTKSSFNEEYTPTIESRQNKLYKFNRKQFQIQIYDTAGSKELNLFVSDSISQCEGFIIVFSLNDRNSILKIQHYKTLIKNIFKDVEMPIVLVGTKMDLKKEITISKNECKITSVNNNIPNLFYTSAKNKESIIPVFKKLVDLIISKEKKVKKETESNNIKINNQNKIKKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHVFKTRSNSTLRMKKYLKLF", "length": 272 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54YJ4-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKKVYQDEEFSFFEIGGKKIADLYVRDIITEIRKRGKEITGLGLKSKYELLCILVNRMKEENPSLNIPPKKRVLDFGSLSSTTSNGILQDSNKFFKKDNTHQHQQQQQQQQQQQQQQQQQQQQQQQQHSNNSDDDDDTHNYNDDSDESDDEYIITEEEEIELHKNLNLGDDENLLTLEIKLLESQLENKKFRKSLLLKDKKIKHLENIIQQQQQQLLEQQHQQQQQQQQQQQQQQQQQQRQEEEQQKEQQQKEEQEQEQSSLKNNLKFKDGANLFSIESISNLYNKILNEFNFKKIITEFGDSSLKIHEEFVKFIILKSINLNHNNNKNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNSSNNLPNGDVNKNNNNNGEIIELVPPPKIDEFWKLMVLDTVGYQQFSNILGAKVNYDTDINPTRKGYQRLKDMKNLYFPPPPSTTELTTDEIWPNHYLLPIQPSPQKQHIQKQQLPSSSSSSSSSSSSSSSSQQHQQHQPQHKQQHQLQQIQEQQPQQQQHQQQQHQQPLQQQIQQQQQQQQQHQPQQQHQPQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQQQQKKQQQQHQQQKNKENNKENNKENNKQNNKENNKLNDNNLNIEVHEDEGNRIINFLISPDTPLRNLFVAYAKEIGENFNSFKFYFGNELLCQNETPSQLLMRNGTKIQAFYLNKKEIKK", "length": 702 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54YV1-1", "protein_name": "Rho GTPase-activating protein gacII", "gene_name": "gacII", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVRKLFNTSHKKELILDVDTTIVKIGTPKNVVLLTKWLDANGAIKEEGVFRVNGNTTTMEQIKKNFSQGKDDLTKYTSADIHSMAGCLKFILRELPEPIFTWDFYPIFIKIQCLQDESRKLFFLKMLIHGLPYTSRTLVFQLFGFLSKFSVHQDQNKMTPKNLATVFAPNVLRPKKEEDNFQLMNNQDSIGVIETLIEEFQYISNIQKNTLNSQEIKVKSVLPFDETTNAITQQSLVEDYLIAKANTPQESSSFKKNLPFKKGDIIKLLYIKNDGNFIGEINGITGNLSQTYVDIIDISELAEAFTLTPPPIPTLPIASTILHTPPTSSSSSSSSSSSSILLTDNQPKLCSSTPRINNSPSSFSPSLSSTTPQLLVQQSPRQSPRQIPSISLIVEPNNTNQPSFGHGTLQRTSTGYFSSKPLSISQPINMSKPTNMSPPTHHAMSMHNLPPSNTTRENHLPPLPTKPPPLTIPSSSSLPTTPIKQQPQQPIQQPLTPQNHHHHHHHNNLSSSVNTANTGNCANILSPNSDRYLSSRSQSSVHLSGSSSSSSSSSSSSSSSSSSSSSTSNRKFDFSLKSKSSKNSPSKNLPPQPTTTSTLTPPPPPTITTTTTTTTTTTTTTIATTPPPPSKPLPNIPVKDQQFNTLKRSTIEIPPPTITSTNINNNNNTINPRTLNYSFSSFSITYNNSQLGGQLSQEEPPGGVKSQSSYLDNNNLPSRNTNIPNLPPRPPPLNIPQQQQQYKPLPSPPQLQSPQSSLNQSLQIPLQQQQQVQQQKLTTHYILPPQNTNLSGKNLQRSSTSMLLNKLPPPPFSFNKN", "length": 817 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZA1-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNLNITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSGSQIHRIKNPSNGEIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZA6-1", "protein_name": "Alpha/beta hydrolase fold-1 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKINQTPKKHKIIEPNRKGYSIVGKNTGKPNKIYFETFGNGPKKILFITGFLSSSKGWCKQIDYFTNKKDQYEICVFDNRGIGKSNIDSKYSYNFSTKSMAMDAIDLLEDTLKWDKVHICGLSMGGMASIHLSSIIPEKVQSLVIACVPNGYFLPFFSMGVFNYIRAFFFTFNEKKKARIFQSLMYSDNYLDEKTNGSDETRSEQMFKKNSTGFKDDGPSFLTILGHQIGYITNRFSKKSLEVIKKYSIPTIVINSKKDSLVTIDITKKQIVNPLKPLNFHVIEGGHLSQLENPTFFNKLVENHVDKHSNWDHSTFFQVEKQQFQRQSFMTQNILYSKNYLSSNTLSSSFLNCNTLRSFFNKIKV", "length": 366 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZT3-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKSGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q551H6-1", "protein_name": "t-SNARE coiled-coil homology domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATRDITSSYILSRTECKNRAKIINSAININIKKSGSGYKRLEEENYQDIDIDNNNNNNNINNNNINNNDNDNDTTNNIKNSNNNNDIQLNILDTEINIEQLNSLPPWILKLNDIDENIKKIISLIEKFKKYLKEDIDKILAEDIEMESRIDCERSIELLTMETIRLFHKTFDMIKYLNKSNNSSQGENKMKKNTQRMKSAKLKALLITFKHIQRSYLALLKKVSSLQRSLSSSFLYRSGEYDVNNDNEDYGENSSISNSHYLQHHHNNNHHHEDDHDHEEDHEEIMDELNEMATTLIERQRVSQLIKETSHLIQDVGSMCVKKDSIFDRIDYNLAEGEELEFNGTILICDGITNGYERPENEKRKKLLLIFAVLIIVILFIFILKYVIEI", "length": 391 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q551V5-1", "protein_name": "EGF-like domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKYLFRFFIFLFCITRINSQTGCFFRETGADYNIDSVFSVFYVDNLFNIFGMTFYMKTCTYVTCDPWRQTMICGNYNSTTFQLGPYQSQKVTLNKNGISIEYLSDKTPPNHPCPTITTTVKFICDKSVLSVPKSDYDYVGTCGVQIKLFAIDYCQTCSKCIASHGSCNSTSGWCTCDSYTMGLNCDQLKASISSVVAPTIDGGSVIISGDFSSIYSLGPSLVITIGSLVCSQVSFAASTTQISCTIGAGQGYQNLTISDGSGSTLQYKQFYYHYPCQEDCTPYGTCNDVIGKCTCNYKYSIGADCKTLNLQLTSVKPTLLDGGQAYLVGDFSNVTGLTLSVKIGIKECTDVNFNETTLQCTIGSGEGIKDIIITSDLLTYSKIGAYEYQYYTCPLGCLHGTCNKYNGLCVCNNGTYGDQCQYIECPLDCSTPNGVCDKDTGICDCDDKYSGEGCDFIKCPLDCSTPNGVCDGKTGICNCDEKHSGDSCQFLQCPLNCSNPNGICNRNTGICSCDSKYSGEGCDFIKCPTDCSTPNGTCDGKTGTCKCNNPYTGENCDEIAKCKQECSLKHGTCDSHTLDCICDTQTKGLSCEESRLLIESADPTSLDGGTTTITGYFGTTTSLLSIKIGDSQCTNIKVESDTKLKCDIGPGEGTHNVTVTDDDLSFTGVGMFQYVGQINKISKISGGAIAGIAAGCVVGVSVLGAGGYYQYRKNKKIELFMS", "length": 722 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q554Y8-1", "protein_name": "ADP-ribosylation factor-related", "gene_name": "arrB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGMGFSFIEKKDFKRFLILGIDNSGKKKIMYRLKFNKDIPTRPEKGFFVETFERRFKYNNEDVCGQNMIRPLWPNYYTDETNGLIFVVDSSDQERIEEVRLEIKKLDENIKIFKNHPFLIFANKQDLKNSLSIEQLIDKLELNKLSLNRKWHIQSSNAITGDGLEFGLNWLFSSSHNFT", "length": 179 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q555E8-1", "protein_name": "Putative fatty acid elongase DDB_G0274669", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METVQSIITEWTDPKSWEKLVQHSFKDSNWKELIDPVNYKFNFGVTPFSQFQIIPIVLVIYLVTIFSIKFLMKNRKPFSLKFISILHNAILCIWSLIMCVGVLYEIIKRVSNEGPLFTVCEDPNGGFDKGVTYYWSYIFYISKFYELLDTVIIVLKKKPLIFLHVYHHCKTVWWKKYITMIQILQFVCLGIAGVLHVYTINTIGCFTHYPAFAAAYSINFSFLFLFSKFFVKSYTPKNSNSNTNIKSKKID", "length": 251 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q555Q5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRSIRIKKINFHIKQGEEQLKQELNNYCEETSLKYISARIKKRHNDFTINAVKDAQGRTINKQELIEEEYVKYYSNLYDYKEDDAPSHYEMLENWTVTRDSTWDNLENEFTTQEILEVIKQLNPHKSPGPDGIPNLFYITHKEKLAPILASAFNDTLRNPHLISKNYKEGLIITIPKKGDPELIKNRRPITLANCIYKIHSKLINNRIIPILTKVINHNQKGFVPGRFIIDNIISMNELINYCNDKRINGIITLYDFEKAFDSISHGSILRSLQHINIPTNIINLIMNLLTKSEARIEINGRTTIPFEIKRGVKQGDPLSPTLFVLVIEALARKILQDDRITGLPLNNSDHREKFQSFADDSASMVPDSQQLELVLQHFNSFCKATSSKLNIDKSSSILIGNPDNTNQRIPISTNPERYLGYFFTGKGITRKIPEILNTIRSSLVLWKTTDSTIKTKTNILKAFALSKLTYYSYVENFKEEELNQINKLVEWFLSAPNTKMLVDFKITPKLSPTAKKDQEVNADYANHRFHKEYFEWNYKAIDYDLTRSFAYRNLMALILHNIWIWICNQIYSEDPLTDESLSYSSLLKKWHKLATLEYIKKAKDLKNLSAKDHNNFKDPKILLTSTIKLRKTTANYYCIPESSLPNIISFDQFI", "length": 655 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556H5-1", "protein_name": "Cofilin-3", "gene_name": "cofD-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTPKPTIAKISPECQTHFQDIKFRNKYQGILLKVNEESNMVVDKTLVAEGEFSELAQSLPTDQCRIIIYRYKSGEGSKLFFIYWGPDSAPQQDKLIYGNAKVTLAITLKGIDHKISASNLKEISEQVFIDRITPKTA", "length": 138 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556J5-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MWNHNLCHAINLDRQFDHINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNSYDYSFSVHSSQQYSRHYPNSCNNEQTKPKDYYDHASRSQHDYHANGSNNGNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNCDSNYNSNNNNSNNISIANIKYQQDQHYQHSDTYTSHQYNSFNDNNNNNNNNNNNNNNNNNINNDNDNNGYNQYDESEEDEEEQDDYDEFDIQDSASSYNDNCGVLNSNTYIYDYQSPQQPLYSNEYQNNNHQPQQTDSYNYNNTNNDNNSYNINNNNNNNSYNNNNNYNNSNNNNNIGNIDSNTNNNNYNYNYSNNGDVYNGYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNMNNMNNMNNNIITSNREQFYSNNNHNNINQYQYQSQQQQTQQQQQQTQQQQQQTQQQQQTQQQQTQQQQQYLTQYYQQELYSQSYKCRPYYQNSFVISKC", "length": 480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556P1-1", "protein_name": "CWH43-like N-terminal domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISSSLKPSVLLWILAILIPSTLITTYTLTVLLFHGIRRTVPYISDTIDFSPESCIGTFFISISAFLVFIVVFVKHFLLQNNINQNFNIDIILNENENEKKKNRAKMLNRISTFLGLICGVCIHGVSSFQYHNTGLVHSIFAASFFFTGFIYIFTQTYLDHKFSKLPKRILILRRVISLTTSVFIGYIILQFFIDNLAPILKIISALSIFFYLISFFYEFSKITINFQINTISQIEHQKEYNENSALLISQ", "length": 251 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556R5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNFERIDHGSGKGTGIAIENRDTRKGHISINFKDDDGRILSIKYNSFNSINILLINAPATISERNTFIINSKSLFKKYNSINHQIIAGDFNNNHDCNSFFGTELRKIIDQDMLLDTGIEENTPTFPRSMKRLDRIYCHPTLLNQNSKLVVHNTVFNKSDHFPITITIQTNRETTTTTTTTKLERLPWTLCKEILNNKHIHDGLSELISKNKDKIKSVEEWTKFKNNVIRDYLKKEQNKIKKEKNKRKYVIHKLLGNSDIIPKMRKELNEEISRILEEERKVKAWDIKLKLHLHQETPSKYLTSILKSRAKDKSIFQIKDKDNKTISDKENIAKRFVEFYQDQYEEKEDNEETHKKLLEKWEVDVDLIKKLEIDRPIRIHEVTKAIKTSSIHKSPGLDGINALFYKYHINSIARILTIAFNDLLTNKKEIPTKFKEGVITTIFKKGDELNISNRRPITLLNTDYKILSKILNSRLLDITSKIINKFQNGFVPNRFIQDNIQIMKEVIEISNKRKNNTLITFYDFNKAFDSISHKSITRTLEHIGIPPKFTAILLNLLKDTKNKIKINDFLVNGITIRTGTKQGDPISPTIFALVLEPLLIDIINDNTIKGFTLPNSKSLKLTAFADDIATFTNSTEELMKINTKIQKYCSATSSSLNKEKTVMIAIGDKPHDLPFQESTVPERYLGLNFTKTGLNSKYNTLIQEMKNNLIKWKSQAITMKAKMTILKTYVLSKLTYHQYMDNLNEEQIEEINNMTRWFLFSSVKNTYTEERKYKTMMKIDRAYADWKEGGIKLWDIELRHIAFKIWYMNRLLHNNYNNNNNTLQEWYMEQLSRKKPTLQPSTICADTGVYSESNFTKTIQR", "length": 861 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556X2-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q557C9-1", "protein_name": "Homeobox protein 5", "gene_name": "hbx5-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METIVNNQNNGQQNTVPTQSFSSSVYMNYDFFDSQQLQQPQHQPQHYQQQDSFVSPNLDNNNPQIHVQSNNYNQNGFVGYNNSNNNNNNNQHMNNQYSNSFHNNNSSGFMAFQNNSSNFNNQNNNNSNNNNNNNNINSYDYNNSNNNNYNNNNNTHSNNSNNNNNNNNSNYWNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNHHHHHHQQQSQPTSPYNNPIQHNPNDMKFNGQHNPFNGNQMVMDNNNNNNNNNNSNVFNSNSNSNVFNSNSGSFLQINNNNGSFSSYNNNNNNNNNNNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNQFSQSYDSTLGNNRFSSMMGQPIQQQQSPPQQQQQQSFIQSSPQAIPASNCNGNGSTSSSTSPLSPTLIGSAPGTPTSMLATTLFGFNLSSSPTSSPSSPVKKGKSQSALALSSSGGSGGSSGRKKPQKHDSMSSITNTNLKSTQASTLKESKRSNSSPNLKKQMQLQQLQQQQKLNENGTLIPPLPFASISENITNNNNNNNNNNNNNNNNNNNNNITNNPLSGSMEFPNSNNINQSSDSINGEFNIGQPESPKMYNSSPSPPPNATSTTKGGKKSKKSLHISTTQQSPSLNGSTGGSMLTPTMSGLSLSGGGSGGGFSPLISPTGTTSNKDLQSSPSPSPLLKSMSMGKLDLQDSIDSMSSPLSPNSSLSSSNGLLPPPPNSNNMNSSGGIPTPSTPTSPPPLTHHINIFSNLEFVKQLKDHLLPNDFKPEEHALERNLLRFQQFVKTLAEPLQRDVVTSMFELSVDAQLQYGSNLDNDNLSALMLFRRKILNFNLFRMMMLNDPNSFIPLPSPFPIQTTTISSNGTIVNPTNVNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTSANTVQSGTTSNSNLVFQQTSNSNTLSPSQQQQQQTQQQQSINGSSTGSLSDAQYQDLGIHLDTSSANSGCGINVSIGSSIGGGGGGSSLNGSNLNGSSSISGSISGGSSNGGGQFIMSPQFSLDGAYQQQQPSSYNINNEMELAEKDEDEIFNNNNKDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSINSNINNVNNCNINNNSNSNNGSINSPRPSTPTTLNSSGKRSKKIYRGDSFGAGNDISTGLMASSDQIIPPPQQQQHQQLVNNNNNNMNNSENNILLADSNKGLSVSLGSLPTNTPSSMEIEQQQQQQQQQQQQQQQQHLNQQQILHQQLHHHLSSSLGGAQFTNIQQQQQQQSGNIFYNSPYNSSQVYMNPYGTSITNTSLAGPSTTSSAMQHMITNMTSSNIIVNNQNNNNNDQNNNNNNNNNNNSTTNSNVNNNNNTTNTPSSPPQPNNCTPTQTSIITSNGVVVPSLQMRGTITNPPPVLPTPDTLVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQETPHTPTSNSISSPRSSPVHQQSPSNTNTTTTSTTTIRHSAVTQLSFAGLHNQQVSPISPRSPRSPHGTSGDYNDGSQSPSSRRKNRFTDFQIKRMNDCFENLDKNNNGKFTSEEICQIATELGLTDQQVRVFFQNKRARSRPSPRGQPTNPLTSSTNNGNNSNLALQHLQQQHLQQVQQQQQQLLQLQQQQQQQQQQLHQQSANTTPQLNSMNPNSINYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNITTINE", "length": 1723 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q557D0-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTGSNNLNSLNNNNNNKISLQETIQDIIKCSICLNSPKNPRFCPRCSALFCLECIDRWIISNPTCPACRDTLTSDNLNSNLIVSNILNELVKSEQEEYTSSDICNYHGYERLYYCSTCQEPICSDCALFKHKDHKIEKLSINFNKNLEILKIEEEALKKRQEELIELNSFLELDAETLLKNKSQIEKEISKVVITMKARLKYDFERRYNTILESQEKINNELTHLDFIYNDLLNHYKKSPSSFVLTSQQFIGVLQSVHKNSIMDIYTPINTDLTSELIPPFENRLLKFENFTTGDCLFSSRIAFYGMTWEIKCGIEEDNCFLNLKVLECNSDGKYFYMFTIVNQKTNVNKLIEFDLPFQAGETFYIPNFSSKQTLIDEGFILPENDILLLQFSFRPQNYFCYSNDLKRYIDILEYRHRGYFGEEDEDDGTIETTVTKLPNDKSTILGSDNYNDNYNDDGIGDLDEDEEEEEDDEDDDDNLDDHLQYDNDDDEDEEEDDEEQNEEDNDEEGTNIPTSEYEDLDTSSASVISNINRRDRFKNNNINNNNQFVNSNNNNNKYNTTNSNNSIVGSSRYINNNNNNNNNNNNNNNNNNNNNNNNNNNNNYILNRSYSTNKIYNFYQDEEEEEEDDDSNIDDQDEDEEEEDSEEESSLSSSDLQDLDSSGDQSSLEFSFSKYTNNYYSNNNNNYNSGGGGGVGGAGDNNKIECIRRDFNNLLKRINFTNSQLTNLKPGVPKDGDLLNDDENDKKCNIPLNEDEEEDEDEEDDVNKNKTTSTTTTTTTATTTNEVVTINPNTISNNSQDEEEVKSDIVKLLENGIANMLNNSNSSNRSSNNLKQQQQQQQQLQKDDQKQKDEQQNKSNTGCDIDQLNILSKLSIKESCDSIKNNDNDSLGNSTNNNNNNNLNNNNNNNNNNNNNNNNNNNNNNSNNNNLQSFLQSNENTENETDFNDNNTNPETNTETENEYLTSSNMNLDGGESEFDSNKSYEGSSTDENFNSDEDYQDEDNFNQDATGSESANNDDYLDDNEREGSDSIENYDEDIEKVLTSHNIITTPSIPPSQQPQPQLQTQPQTQPQSQPQSQPQLQPQSQPQPQTQPQLQPQLQPQLQPQLQPQLQPQLQPQLQPQTQPQQQKKYDDLSENQIQTENRNKKIKEEINNKTNNDNNNELGKSSKSNTSSSSSSSSSSSSSYSESESSESDSNNEYDNEDEDDIVNQVSNFNFNFNDASNFKNFSFRPKFPSDENDNDDNDDDYEINIDLKNIQKISPILRAIENGESNINHYQSPVSLSSSSSVSSFSGSGNSVPITATTTTTTTTTTTTTTTTDDDSGINMPISPLSASPPSPPPQNEPQINNETNDNDVKLPQI", "length": 1364 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559A9-1", "protein_name": "Probable polyketide synthase 13", "gene_name": "pks13", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENFKYRNNENDVAIIGIGFRLPGCKNFTPNELWNNLKNGFNGVVELSNRWSDNFYTMGKVSSAYAGLLPFDELKSFDPLFFGINPTEVPTIDPQQRILLKCTWEAFEDAGIDPIKIRGSNTSVFIGTSTNDYQRIIREKDQTITNAFGTSLHATSNRISYCFDFRGPSMTLDTACSSSLNCVKLGYQSIRDGTSNLSIAGGVNLIIDPYFTASISDLNILSKTGSCKTFDASADGFARAEGSGIIVMKNLKQAMIDGDKIYCVIKGASSNVDGGGLQDKSNFYAPSSLSQCNNIKMALKSTNGTVEPKDISYFECHGTGTPTGDPIETRGISMVFNDESRSKENPLLIGSIKSNIGHLEAGSGIASLIKCCLMFKNKCFAPNINFKVPNPKIKFEEWNLKVVTEPIQFTKSNTCIGLSNFGVTGSNCCLILSQFNNNNNDNQIVGNNNNIKSNKEYLIPFSSNSVKSLENYQQLLIKNGENEFKFLEFIKHQIFTKPTSLYQRSVVIASSWDQFNNAKIMKTSNSKSSNISIERNNPITVFVFCGQGSQYDRMGLELYNNDFIFKESMDLLDNKLSKYYGYSVLEKLRNCDSKSIQHPMIAQPVMCMFNISLFELYKHWGIEVSFIIGHSLGEIPAAYCSGMINIDTLCYLIYHRSIAQTKTHTNGRMLSINISADEYFSQYSKQYPDIEIACFNSPTSIVIAGNEQKLNEISEILKEKGIFSAMLASLSSFHTSSQNKVKEDIVNKQFDSKQSEIPIFSTVTTNLFDSVTSPFNSSYVFNNIVSPVKFSQTISNLYKHIESNQLGNDIVFIELAPHPTLQFYLKQMIPKPTNDDNSIEFKVSVYSALNKKNNDIEEIQRTISQLYCDNGYNVNFKCQFQHDDTHGSINSNINQLSNISLPHYQWDDEKYWKEDPSISKLIVNGPQTDNLGYLNENSPNSKSYETFIDIKRPPFQYLKGHMVKGKYYFPGCGYIDNLLKIYKSQDLTINQMGFKSPLIFIEGVNQALQTNIFKKSTSNTTTNNNDEFRVEYHFNDQKTNRWILSSFGDFQLSNHSSNSDNLEKINIKQLIQNQCNLTKLSRDELYSHIKSKTGLTYNGVFQGVNKCYLGENCSLSEVSLELKREPSSFFNTAVLDTCLHGMLCLLEEQSQLVFDRIEGFKYHSSNVPTSEEEMKIHSNIYVYSTINPSRIGDSYSASIVIMMEDGTVLIEIENAVCTSLTPIKESISVKYPTNQLFSMYLQSKDSPIPSPLNFKSLYNQNQQQLKIDKQFTDWMQKCEKFISNQFFKNIEKRNPEINLEILNSKTIIELKSKYCQNLKNERLFQFVFETIKQLGVNAYDDDDDLTIDSSEDRKSIYEILIKSTKVIPKLLFPLEDEDLTIDSPQSLFENGLLDRFYNNPNLMTNQCQLIAQIIKESLKPLLNKKMVFRILEMGGGTCSLSVVVLNLINQLLLENPSFEIDIEYTWSDISPSFISAAKEKLSHIDKRINILYRSIDIEQPFIEKQDLSPSYYDFVIMSNVLHVVKKLSPSLDEIHKILTPNGHLLFVEIPYKELISDSIFGAFNQWWAFEDTDIRKDRCSIPPNQWIQVLSNHNYKDTIVSDNKECTWCCFVIHSQKPSLLELSKKIECNQYDNIIVFGNENSQDNFTKSIKLSYNNNIIKWVSNIVEIKKFIKLNIITNNSIIYFTKGIEELTIDNFKLINFQYIQINQLLLKYESKCKNVLVTRDCDGSNYLASSLIGAARYFDEYRQLELFTLDFDNDTIQSCDECSSSSCSNLIKLIEPLIDPKINIQREFLIRNNRVYFERAKLETNLKKSFKSESFENSNKLISTLNFNLDYQLQSKPFKQLLQNEIEVEIKATGINYRDYLVFTGSLPIEKTNHNGISNQPEFGVDFSGIVTKVGGGGGNGEFKVGDRVYGIGHNTTSSHITIDSRYASLIPNSLDYIEASSITSSYILSLYGIFDIGNLDIQDNESILIHSGTGGIGLSALNSLRWKGHKSHLFVTVSSKEKEQYLRDNYGSFITGIYSNKDKNYPKLIKEKLNQLGSNKQGVDLILSSLPNGDDNLNFKCLAKNGRIIDLSNNIDLFNISKSKIKKLLNTINDGFESGELQVIPIIEFSNSNIRDAIEFINERQHIGKIVISHDDSNLLIDLINKHSNQPNYSILKSDYQISQSNLGKNILITGQSGIVLEILKWIIKFSNSIENVIILSKSLMKWELELLIGKTMKKANNKIKFHFKSVDVSDSIQVENSINQILNDNPNIVNIDSIFHFAFTQITKKVEEIDMESLNVSHNAKTIGAINLHNQSINRNWRLNNFVMASSATSIIGSTDQCSYVCANTVLDSLSKYRKSIGLPSICTNYGAIESAGFVSKNESVAAMFNGIGIISISTDLILGTLDLQIQNQQSSTNLMLSDFNFLNFVNNNLQLSLISKFDFQTNLAKNQVNEKLQNQTQNQNLQIQSPSSTTDCQTIIKDSFLHKISEVLSIDISKLNLDLKLLDYGADSLAIVQIKNWIDMEVSPNLIVIQQLQTFTITSSIQYTINSFLKKKVQSQE", "length": 2551 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559I8-1", "protein_name": "Uncharacterized protein DDB_G0272530", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKIKLILVLIVFLTIVNVNNSIDLCLSNPKKALVNQACKYSTDCEYPLFCGSGNGYGKNATCSKNIETGGSCESNNQCTPCNVCFNAKCKVKLYLGDACDENKSYCSSSVCIKGKCSIQGDVCTANNQCKFNNYCKSGKCVPLEKEGSSCDKDSSCSLTNACVGGKCVTKYQKPLGAVCNSSNECQVFSGHVCGANGKCSVYNQLLSKCKENSDCGPNGMCMCKSETENVCVDLSVGALKNDKCPSLLSSFSSCMTRERCTENTPTGCPKCYPIFMCYQYSCFYMNQFIRSTQNYYKSFCS", "length": 301 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559Z2-1", "protein_name": "E2F/DP family winged-helix DNA-binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNISLLLNNRNRNRNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNGNANESASLNNGSEEIRSNPSSNFSSPIQSSLSSSSSSLSSNQATTPKKRSHAHKNSLKCQSPQMSPQMSPQMSPQMSPPLQYFPQHQMQHLSQYQLDHLQQQQQLIQQEQQEKQQQQQQHQHQQQQQEQQKQQQKQQQRLSPQPRSSQPRSSPPRSSPQRSPQLNQQEGHINSVQTYSGNNINDKNQNNTNNNNNNMSNNNNFHDDNNCNVNYNNIRNNSNNNNNNNTNNNNNNNNNNNNNNNNNNNNINNNNNNNNNSNNNNWNNNYCNNSFADETNKNNTYGMEYINISEENQYNNNNNNNNSNNNNNYNNYNNYNNNNNNNNNNNNSNNSNSNNNNNNNNNNNNNNNNNRNNIINSNINNSNNNNYNDNGYNNNSNINSNDSYNNNNNNNNNFNNNNFNNNNNNNNNNNNNNNNNNNNNKNNNNSNSYNNNNNNYNNNNNNFHNNNNNSAHNNNNNNYNNNNNNNYYNSNNNNNFHNNNNNNNNNGNNFNNNNNNNGNNGNMFTNVNSIDNVNRNNYNNYNGNNNYNGNNSNNNNNSNNEVSQITTTSLPVKKTKVFKAPREKKFKRGPDQDIREIKPATALLKQYFIGNSITEFNAERVGSILKINHEKLKDILDIMECASLVINNHSNNYVWLGLDNPGFLKLVFNVFHCSSNLVTKEPEFACLKCKENAYRCPTSVDLPKDTRLGSTVCQFMKLLLSKRIRTNPVNDFLTIYQVCFNFNFCSEGRCPEEDFKYLRNTAKVKRCYDVANVFNGLNILEKVGKSKIHSYQWCGDFTIQDCENGCPFGHPLLTPGTAYTTNPSPNPFNQFSNAYISSSAQSSLSNSPFIQGGFHGNNNNSNNNNINGNNINGNNNYGYNNNNNYNNYNSNNSNGFNNGNSFFQQQQPLVNSGVSMVRNNNYSYSP", "length": 964 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55A39-1", "protein_name": "Transcription initiation factor TFIID subunit", "gene_name": "taf9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSNETLPNSEQENNSKTDTKNDNKNIGDENKIIDTDKDMKDNDTINGKENGNININSNNNNNNNIDTDKEMKETSSIEEDDNNNNKNQNNNNNNNIKEENDNLTELKNNNNKENKENKEETIKEDKEKENNKEPVKNKEETNNINNNNNKNNNSDNINNNNNNNSKETLNKISSMSKVSLTSESSEINGQVNTGVVNNNTNIDITQTNLDEPRDSRVIKSILKTMGIQAHEPRVVNQLLEFMYKYVFEVLQDAMIYGEHSGKTDIDVSDVRLSIQSRVNYQISTPPPRELLLSIAEEKNKTPLPPIPNRYGVFLPPDEYCLTNPNYQANPTKPVFQPVQPLVGNTSRGNYNKKQSDKQVSIKFNSMSNNSTTTTTTTPPTIGSQNGTTIVSPPNLGSLGTTTTTTTTTITPPPPILPLSSNIKPPTLSIPSSITSPPTVTTKNTSTPIIGLGSTTVAPPKTSSSSSTIAPPVLSLPTSITSPPTVTASSTTTTTTAPTTTSPTIPSLSSPTTAATTITVKKEDVKMDDFDDFDGQMKDDITPSSTPQQPSQPTESETTTTATATTTPAVTTTTIPPTTTSTTPPTTATTSTTPPPSTTTTSTPPTTSTTPPPQIKEEK", "length": 619 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55B17-1", "protein_name": "Amine oxidase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKKILLIFALFILVNINFASSEFKKNETESANLKSLYASYLMKNNNNTKYNNNDNSNNTNIYNDSVTKNKSKNKNELTVGIIGGGIAGLYAGMLFIKSMIFDDLGIDYTILEANKERVGGRVYTHKFDDHKYSYTDLGAMRIPLTPLMDRIVSNQNYSLFSKLAKGGYQIPTVPFLISVNNEISYYNGIRVLKGSPVLNPSDPFNYSDSNNGGPGKGIPDEYANRTVDSLILPVFYQFINNLTVDFYNGFKQMLKYDSYSARDYLKTFHNYPNSVIEYIENLSTISGRLDQTSITELLMSVFDFSGEKFVCVEGGTGLIVKSMSQIIKKKVEMGSFVTKISKSFDKKNNEIDGLNVEVVRDSNFGGSDTEILKFKHVISTTTLPALQRIDTSDLKLPLKLKVAIRSLKYTGAIKLAINFKYRWWEDSEFMSGKPIRGGSSNTDLLLRQVVYPSYGINNGTKGVSGVLLASYSGGLESIRISSMIGKKDKERKLLNIVLRDLAEIHNVDLKKLKNLYKDHFFQSWDNDEFSSGAFALFSTSQYTELFPSTGQSHVDGRFHLSGELTSVHHAWMIGGLNSAYRSVDLILKNEGFEDLRIKLRNNWGTIEQAEYPSLDWYKYDSDINHYKLY", "length": 630 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55BT6-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLLYIVVFLLFAIKLCCSEYCGETYCVENRNCYSFIGCRNSTCLYETIDLDDEVDCTVDTCSDRYGVKNTPNNSLCPPENLCDMFLCDTQSGCVAIPKVNCPAPNPCQIPLGCNRETGICEYDEIDCHDDNECTNDYCDPILGECVHFSNDTICSNKASNFSTCVLSGVCGEFGCKYVEDNCNDGNPCTDDYCDFKNGCVSQKNDWNCDSLSACSEGICTDNGCVQQEVDCDDDNPCSEDFCHPLFGCGSILNDTICTNGNKCVNSTCTEDGCSLPVPIVCQDGNPCSDDTCNPSTGCQFTLNNSNCNDGKKCTIDQCGLNGCTHTNITCPPKRVVDIILIGLICRNHYCDQSTGNCVPDMNSVSLLCI", "length": 370 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55C69-1", "protein_name": "Chromo domain-containing protein", "gene_name": "hcpC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGKTNKKKIEEESEEEEAGDVFEVEKILDKRVQHGRIQYNIRWKGFSADYDTWEDEANVVGCPELVREFESSRIKEKKKNRKRKNVIIDEDPTEEISSSLSSILSSPQPQPPPPLQLTNHSPASSELAITTNTFLISNCTSTSNKTKISIENEEIIKNDHARYGVPYVEGIGFENGDCVDEIVGCKPFGENNLLYFFIRWRGKEKLSWVSNESIKQKEPLQLIEFYESRLKFGYKGEEN", "length": 239 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CH5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKNNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CH7-1", "protein_name": "SsDNA-binding transcriptional regulator", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIFKITRTKRRWTKNQKKILVMKVVEKKVVVKKSKTPNTSPSSSSSSSSSSSSSSSSSSTNDKSFNLSDKRKISYSNFKGLERIDIREFFEDKSGELKPSSKGISLTREQLVVILENGDTIKDWIKESK", "length": 129 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CJ7-1", "protein_name": "diaminopimelate epimerase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEPSIDNKPSFRINFTKMHGAGNDFVVFEKNKVERLNGDKSTVTFEEIVGFTTKIAHRKLGIGFDQLIVIDDNPIDKNAAYGMDVINCDGNIEVMCGNGVRCFSKYIVDNKVLSKNLKEQLNFDGDDDIEQIIETKSGIVKTYPLLKHHLNNKDNDVIMVKVNMGTPKVSRFINEIDRHIPKVLTNQSPIESYMYTIDIGLPYCSKLECVYVTVGGNQCVVFIDRNIELGYLDSSYGDHTKFSTIDFKEISDIIQSNVNGFDDIPNVEFVIQSPQDKLENKVISRVVERGNGETLACGTGACGVAISSILKGYCNENTEITVEMPGGKLLIQWNPNNEIFKTGPATSVFKSQILI", "length": 355 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CV8-1", "protein_name": "Lipocalin/cytosolic fatty-acid binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MELLVGGTILGALTYAYSSLKRTIPEGAHACSPFYPEKYVGKWYEIARLDFYYERDMNNVSAEYTLNKDGTISVINSGYNYVEKKRESVNGKALFVHGSDEAMLKVSFFGPFYAGYNVIAIDPDYKYALVAGRSLDYLWILSRETSIPDHIKKQYLELAESIGYNTSKLIWTEHDNINNKKD", "length": 182 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55D49-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNINITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSSSQIHRIKNPSNGEIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55D57-1", "protein_name": "J domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIQVKNKIKIISILITLFILTINQVVECKSSLYYSILNDYEKGIDYYKILNVTKDSTYSEIKKSFRKLSLKHHPDRNVEKSSHSLYILLNQAHSVLTTDETRKEYDELLVNGIPWHENYYGKYAYRYTGISHDLRHVLLGLIIVITIGKFVYQYNKHHSMIKRAKQTDQYKKRLAQLDGDEDEIQLVIQGADKPTISSLFIIQLFFIFPFKILKSIYTFIFINKFKFIQKTDEEKEEEYRLKMGYTKEDWEYHKKKSIERMEKLKQSGKYKKYLRSKNK", "length": 279 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E25-1", "protein_name": "DRBM domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNKSHTSEKVQLNEFLQKKKQPIPIYHTESKGSEHNKDFKSIVVVNGKQIESDWKKSKKESEKDCAKNILEFIETLDGYPIYFTPFSKDPPQNNKKIYDEKLQAVYNSVSSGIEGLNNNSFFTKIENNNNNSSSNNNNNLDHNHSNDSSHTSTDNNDNNSNNHNNNNNNQINIDLTMENVNISQSKTITNEGTLNNDNDNNNNSIQQQQHQPQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQCFDKDKTNLKKKKKIPFSYNTDLIEHIDLFKRQDFPQTYPSRTTYTDTGHTQQLQKQVFLLTEKIGLMELFYKKQIRVILKSHHNLETELSALKSFVEDCSVTPIEGLELYSIPVPLNPNAKPSAGTTPVLSKSETQNEIIQPTKPPTKPPASCLIKKKIPNVNMKATNKTTTTTSTSTSNSSTTIKTTDSFKNTTNNQHPNTLKPMVSKINQQTSDFIFPLPKPIIRRNPIGNGNLEKKIEKKNSKPNTIVLGVDTQSQSKTKITPSPTTPPPETTPTTPTTTATPTTPTTPTTPTTTATPPPTTTATPPPTTTATPPPTATTPPPTTATTTPPPPPIIATTKTTATATATTIPIDLNEIQIPIRSPQDLTVNQSMISTAMMIASAAQRNPKLTMKLKRKLEESPTLMSKLQKIQFEKEEEILCSQDLHSPIMSPQSPTHQPKTLEPLSPTKKSTQKSPPPTSPSPIVTRARASSNLLPIQNLISKK", "length": 733 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E47-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEEYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKSGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E48-1", "protein_name": "thioredoxin-dependent peroxiredoxin", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTKLKVGNIAPDFEAKNYLGQIVTLKEFKEKSQPIVLYFYPKDNSPECQKSCEFRDKYQKSIEAGAEVIGVSSDGEDSHKSFVSKYSLPFTLLTDKHSKLAKLYGVNGILLPGRKTFIIDKHGFMAVFMMVYSVQLLMSMNL", "length": 142 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55ED8-1", "protein_name": "Decapping nuclease", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKQTLNVIGLINFIKKQRSFNKSPITITKPLEITRFSYEGNQLFPAKLKKFKNPTIDSDLLVGFQGPDSIESDSQTPLSLVLNKLIETKHDVSKSNFISFRNSFRKLFESMYDSEKWNIQVQRINSTIHLGMDNPTQDFHQLKNFHLKSMYSGNYFEKISTIDNNNNPNDNKHKYCSIIQSKLFNNNFILACEIDCWKKSIQNNNNNQNNNNNENNNNDDDDENYNIDDYVELKTSRDIEDSKANYQFRSKKLIRIWFQAYIAGVSKIFLGIRNDDFFLKKCLNFNTHDLPNQAINWNKDEMLIYGNEILEFIKNNTCSGKSYTLSFNYPIISLVESDSINIINDQYLQYYLNIPKNFENNYNQNNNQNNNNNNNNENNSDDTKNNNIQNNNENNNIQNNNENNNQNNNEKNQKRNFGEEKEIKGDENEERLSKKQKKLE", "length": 440 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55EZ2-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEEYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55F94-1", "protein_name": "Dynamin-like protein A", "gene_name": "dlpA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVFKKKDKSDDKKKKHDEETPQGTFQPASQSTSNTNLNSLASSVNNGASVGSTNGSTPNNSNGSTPTYNHNNSAEELEKQKKEEDEKRKKSELEAAAAVVAKKKEDEEKQRKEQVELERKRRDEEIRRTNAAAANAANKELNEQVEISSLEQMGKLDPSSTIHDMFSFFPNEVYNSYEKLQYFSRDLNTAVSHPEIVFVGPRSSGKSSLIEAFIGRALNIVGGGNIVGVGGSNANGCSKRVLYLQFTNNIDFEVPKVTIKKDNTIKEFDHDIIVSIEQLNENLAKRNQLTNDYIEEPIYVSIESRTTLNLTLIDSPGLLFDQSQAESNKIESIVSSLLRPSHRLIIAVESCSQDWKSMSMGQYLKKIDPELSRSTFVFTKFHHTVRGFSSTRDINKYLSGTVPDIKGFFVTLPNHQVRASYSEANRFQEKIYQAHKRDMHALEQLQYDKRYERTIGVAPLRRYILNIVWKSYQDTIPRILKHLRSKRQTAEATLNELQKQSSSLDSTKLRSIASNYTVTFLQITEKLLSGTSEGNPSANGQTLDEEKSQQGDCGEWVDAYKEAIYIDPEEWNIPYWSSKLYGGQQLERLMAEFKAVCDNSKISEVKMDDIATASGINKLNNIPNYAWAASDLTSLISRDTFVPLIEQLCERAMYIMKRLTDIADKVIDSRRKSRCIGSSPFGGNGLNNINSGGNNGININDRLSNTDMDSLDQYPFFTHHVKNLYYDFVHRAAKGCKEKCMDEFYSSRTIYWELTEHPDSSLPSIRNDHHETKTAVCQLATKLFDSIRQRITKNVLLKLYNFFLVPMQTDLWNEIQAQITCLSNEQLEQLFEVQATREQLKQEEKKQQQILEKYSQIDEQFLKAASLFCRPLSNPTPSA", "length": 880 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55FX4-1", "protein_name": "SET domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDINSNHIKKINDFKDKGNKEFNKEKNKDKLNKRAITYFQLGIKYFNDEKHKIEINDQINKLISILYSNLSLMYLKGDEIILSLEASNKSIEFNNQNSKAFYYQSICKSYLCDYKGSMESIDKAISISKQDEKVVQQRNRLIEITNNKVKEDVYFENVLKNQKLENVAYENSIEKGRYLISKRLIKRGEEILRIAPFSFSLNGKYVSKFCGVCYQKKSIDNLLKCKDCDDFAICKECKAPNEPLSKYHPNDLCVLYKLNNEYYKMNNFEIANEDNKERGLTDERRLYINTIYNIFKNKTNNKAVVEVDNAISSSVIDVLNLSKKLLNHTNESQRAYSDSTKMKTDILELIFKSFYGANTLKKDEISNIIRIVDCNSHGYSDVISQKKKASGLYPFSCYTNHSCIPNSDYFIDKHGVMVLYASSDIQESEAITISYIYFLNRVEKRRKDLLNGHNFFCTCDQCSFQSSLTEEVCDKCNEIIPSTIGNSNLVYKEPKSLKETGFNYICPKGHTKSSLVYDIDNDQLYPTIAENYSKCKDLRNFRKINIFKEMLENRDFVKKLTPREFEVTPLAKYIANPKKSNSMLFEELINLVRGSVECGLTKSIEESNYSTYLVYDYYDLYKSLLLESKPQILKLNSIRDIIIKLLTPMVYNQNKPRIDKKLNKHLSNKINLKKNK", "length": 676 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55G93-1", "protein_name": "Tubulin-specific chaperone D", "gene_name": "tbcd", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENSEDISLNSSEKSIESSVVNLEDQQQSQQQTQQQTCQKTFVQEAPELTILIDKLIQLKHSNKDELISNTTRIIYIIDQYLEQPTLLDIHLNDIIQPLINFIKSNYINNSNNNNTTTTTTTIMTETEIVIKKLSIKNSFRIIYVLSKVRGFKTIVKLFQHEAIDLLPVLDQLEISYHQWVNINKQRDRLNEISVSYSSGINLKNYIKPEEESEQEVVDENNNNINNNHNIDDEYNENIISWEEVYVLALWVSLLVIIPFKFSSLDSASSGTASAAGDGGDGDGDGQLKSISSRILKLGKLALSDVSKIRDSFSELLSKLLNRPDMKFEQKQFIKWCTNSIQLISNNNNNNNQNNSSNNNILLIIGIYSTLATMFKKGNRLDFLPIDMNLYEKIMEANKYLSLSGSERITKKIFLKLLQRIAIIMLPPVSASWRYQKIIKPLLLKGELIKQINNNNNNNNNENNNEEGEEEEEEIPEEIDEILEEIMKSLKDKDTIIRWTSAKAIGRIVNLLPKDMGDQVIGLVIDQMFEKNEFIDADPSAWHGGCLALAELARRGLLLPERLDVVVPLVIRALFFDIIKGTYSIGSHVRDSACYLCWALARTYHNSILSPYLLPICRNLVVVSLYDREINCRKSASAAFQEMVGRHQGLVPNGIEIVTSADFFTVGNKNNSFTSLTTFIGKFQIDYYPIVIKHLATIKIYNWDLEIRQLASKSIHLLTNINPNDIVSNYLPLIIPNTQSDLVHVKHGASLAISEILISLFENNNINLLSDNLKMMILMTIKNTKNEKLFKGKGGVLIRIGMCKIIYSICLVEFSLDKNLSEIKKPTESTSTNGNEDRAAALKLKIAMLKAKTASQINKPIITPPSSKSTTNNNNNNNNNNLNDNEIAFNIILGYLNENLNHPNEEVQKEASKAFELLFSKYISSNEKISLLLELIDSHCKTLKFDINRSARRGSSLLLGSLPFNSANLSYDLLSKVVNELILSIFQDDPKFKDIETRVNSISSLYKIGIYILNLIFKNQENEQKEEEDFKKSKNYNLFIKIWNCLGLATNDYSIDKRGDIGSWVRELSCKVLFDFIKFIITNQNSSTTTTTASTTDLSIENLINEKMITEFICKLFQLSGEKLDKIRDVACKIIHELLWIENPSSINNIPHKEELKKIIVKDQDVHFNWFRTEESLPLICKVLKFNCYLYPLLFGLFSSLGGTSKYLINDSIQSIKQYFSSFDNDEKERFEKIISFSKAILEITNNTTQRMIQPTFRSIYNLLSTHIFDFLIINNLNEQSIFETILFNCYQIIESNQDDIYLLLNSIELFSYFFIQFENNNNEYIKDYSLKALLLLLSNLKYPKVRKLASDQLKKSTRLFINNNGDDETPSLIKSLIFNTKWDDSVDLIIEPLKSLLLLLNQKHLLELLSENPTKKPIPLAPPITSIEELKDKIQNPHKQSDDNNNNNNGELINNNTENNNNNNFDDNLPEDSQDLMEI", "length": 1480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55GP8-1", "protein_name": "Rho GTPase-activating protein gacO", "gene_name": "gacO", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKLPPPPVQSSPQGFQLPSLHSVQLKPVRPPPQPTQQQLASNTSPREVGTSLSPQSPSNNINPSSSSSSPSSSIRQSPSSSPNVARKVPPTPTNNNGGPPTTTTTTTTTMPPPPAFIKKLSPSSSPILPKRIVSSPPLNGNTAPPPPPIVHLPPPPPTNLPPPPTLSPSSSTTTSPSSSSLNLSGGVPLPPRILRNSDGSANNNNNSNNNSNNNINSLNLSTSGGIPPPPSFFNNNNNNNNNSGSFVNSASSNGSPSLQSQNSVGYFKPPPPPVPTRSASLDPKQMGQFIKPQQNQNNSNNINNINNNNNNIILPPPPNININNNNFVPYIPSNNNQQQSTTPPPIVSISPLKRNSIDNSVVNKRLSQDLNTMLVNRLQHGLSPPVATPFFDDKILGSASKSAELKEKRDQEERERRERERIKKEKEDSEKKEKKEKKGKEEQEKKDKKKKEEQEKKDKKKKEEEEKKSKSSSSSSSSSKKSSSDNTIVNQNIFNNTLSQIMENQRDAQSLSPSSLPYPLILKLLTESIMSLNGPYTEGIFRITGSGTEVNRLKKQINEHDFSLDTQDPHVLAGLLKLWLRELVHPIIPSELYNDAIKSRSKEEVSRIISLIPDQNKEVLNFLIPFLKNVSQPHYAQYSKMDIDNVAMVFSPGLLRSTVLTTDLLLNSQYEKDFVKCLIEMSP", "length": 684 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55GR8-1", "protein_name": "Thiamin pyrophosphokinase thiamin-binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKQEEEVQQQQQQQQQQQQPDKNNKETITWDVAEYGGYLFDKKLKAHNPLNHQMPLQYHHSQSTPHIPSSLSTSSTTSIKKPSSSLSDDESGGSSSSTPHSSNTPRKQFSFDDHCALILANQKLPKKLVDYFWDKCSVRICADGGANRLYSLGTKINQSSRWIPDYIKGDLDSLHEGVSDFFSKKGSSIVLDSSQDTSDLQKCFELIIDLEKGSGIKYRKIFILGGLGGSFSHEFANVNTLFDHPGRKIILASKDNLAWLLSSTYNHNIICRSETKCSLIPLSSKASQVTTSGLKWNLVKQSLNFGELISTSNVSLDNKVCVETSNPLIFIVDINP", "length": 337 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q561S0-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "Ndufa10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRLLRLVPASASARGLAAGAQRVGRIHTSVHCKLRYGLLASILGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKHYPEAGIQYSSSTTGDGRPLDIEFSGSCSLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSDALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVSEIQSRIQKKGDPHEMKVTSAYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTKVVEDIEYLNYNKGPWLKQDDRTFHNLRMLVQDKREVLNYTTVPVYLPEITIGAHQGSRIYDSFRELPGRKYAPGYNADVGDKWIWLK", "length": 355 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q568T5-1", "protein_name": "Chondrolectin", "gene_name": "chodl", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRATLRILCALTFLVSCSRGARVVSGQTVCQGNPEHPCYKIAYFKDVSSRVAFWEALQACEMDGGSLLSIENTAEQKHIEHLLRELSVSSSTGPASITDGDFWIGLTREEGDNAQEPGAFASCPNLYRWTDGSVSLFRNWYADEPSCGGEACVVMYHQPTALAGPGGPYLYQWNDDRCNMKHNFICKYEPESHLVKVQSDRPGGHDVDLSTEDKEDRRTPPTDEDESPRLIIAGPSSMLLIYVIIPTIPLLLLILVASGTCCFQMLSKSKPRTKTSVNQSTLWISKTPKIDSGMEV", "length": 296 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5HYN5-1", "protein_name": "Cancer/testis antigen family 45 member A1", "gene_name": "CT45A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKAKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI", "length": 189 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5I0J8-1", "protein_name": "PHD finger protein 11-like", "gene_name": "Phf11l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQEEPGGSNSVLNGDANSDKKMEKWTCALCPEGHDWSVIYFEPSSNIAAHENCLLYSSGLVECGPHDPRNPARSFAVKSVKKEIWRGRRLKCSFCNNKGATVGCDLQSCPKNYHLHCAKEDRAILQVDEDYGTYKLFCQRHAPGGQEPTQVDAAVKASFLKKCLEAGLLTELFEQIQQKMISIHGRFMDDTASESDYEGIKILLFDCGLFKDTLIKFEEAIKSKACECEERLNQMKQQLELLADLQQNLRSFQECGVLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL", "length": 293 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3E6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSKDLAIGVIFILQCSMGILRHFILLSYYLMLHYNKHSLKPIDLILMNMFIANFLIIFPKSMLQTVEAFGIKLLFSVFVCKFLLYIERVGRSVSIATVCLLSVFQAITISPRNSCLYGLKVKVPKYISLSIFLCWALYFVVNMILPVYAYIKWSSNNMTYKRTLKYCFSVGHDEFTGSFFTILFVFPEVFLAILIVWSGSSMVVILYRHKQQVQHIYCNYASTRTSPESRATKSIVVLVSVFICFYSISSILYGCIALFCDNSWSLINIANIISLCFPVLGSFVVSHNPDFPRFSLSWIRNTRRV", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3E9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNDRMESKDLAVGVIFILQCSMGILRHFTLLSYYLMLHYNKHTLKPIDLILMNMFIANFLLIFSKSVLQTVEIFGMELFFNVFVCKFLLYIERVGRSVSVATVCLLSVFQAITISPRNSCLNGLKVKVPKYINLSIFFCWPLYFVINMILPVYGCIKWNSNNMTYKRSVKYCFSIGHDELTSSIFTILFVFPEVFLAILIVLSGSSMVVTLYRHKQQVQHIYCNYACTRTSPESRATKSIVVLVSVFICFYSVSSILYGCIALFCDDSWWLINIAHIISLCFPIFGSFLVSHNPALSRFSLSWIKNTRRV", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3F0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "LOC100911184", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDFWNLAIRIIFLSQIIIGILGNVSLLFYYLVLYYREFTLKSTELILMHLMVANIIIIFSAGVPQTMTIWGMKQFLNDFGCKLLLYIHAVGRSVSICTTCLLSVFQAMTIRPQKFCGNDHKVTMERYLGCFISFLWVLYFLVNFIFLVYTYIKKNSNNETRKRDFGYCSTVGSDKISDSLYATLVMCPEVFFSVLIAWSSGSMIVILYRHKQKVKYIYSTHVSRRDYPESRATQNILAQMFTFLAFYTLSSTLRGSIALLSNHSWWLMNINHFTSLCFPSFGPFVLMSHYSIVSRFILFWLRKNCSNFLL", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5JQC4-1", "protein_name": "Cancer/testis antigen 47A", "gene_name": "CT47A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSATGDRHPTQGDQEAPVSQEGAQAEAAGAGNQEGGDSGPDSSDVVPAAEVVGVAGPVEGLGEEEGEQAAGLAAVPRGGSAEEDSDIGPATEEEEEEEGNEAANFDLAVVARRYPASGIHFVLLDMVHSLLHRLSHNDHILIENRQLSRLMVGPHAAARNLWGNLPPLLLPQRLGAGAAARAGEGLGLIQEAASVPEPAVPADLAEMAREPAEEAAEEKLSEEATEEPDAEEPATEEPTAQEATAPEEVTKSQPEKWDEEAQDAAGEEEKEQEKEKDAENKVKNSKGT", "length": 288 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5JRM2-1", "protein_name": "Uncharacterized protein CXorf66", "gene_name": "CXorf66", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVSSKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYSEVDSDKVIIITCDRGYNQVTSEVTLND", "length": 361 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5QNN9-1", "protein_name": "Trace amine associated receptor 12e", "gene_name": "taar12e", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMSLNETQTENILLCYPLLSNSCPKLHRLAVVQVGLYVFLLLMILTTVFGNLLIIISISHFKHLQSPTHLIVRSLAACDCLLGLLVMPYSMVRSVEGCWYLGDVVCKVHSSLDMTFCISSLLHLGLISVDRYWAICDPLRYRLRVTNITVTVFIVFIWLFSFVYSFYVVFSGVNTVGLETFIMQVYCVGSCVLYFNKQWGLICPILVFFLPGAIMSSLYMKIFHVARKHAKVMSERVTGGLKSQSSAQRERKAAKILAIVMGVFLFCWLPFFTVNALDPFFNFFTPADIFDAVIWFAYLNSTCNPLIYGFFYPCFQKAFKILIFTYICGVRNLDTFA", "length": 337 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5QNP0-1", "protein_name": "Trace amine associated receptor 12g", "gene_name": "taar12g", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSNESENIQLCYPLLSNSCPKLHRLAVVQVGLYICLLLMILTTVFGNLLIIISISHFKHLQSPTHLIVRSLAACDCLLGSLVMPNSMVRSVEGCWYLGDVVCKVHSSLDMTLCISSLLHLGLISVDRYLAICDPLRYRIRVTNTTVTVFTVFIWLFSVVYSFYVKFSGITAVGLEMLILQTYCVGRCVVFFNKQWGLICPVLAFFLPGAIMSSLYMKIFHVARKQAKVISERVTGGLKSQSSAQRERKAAKTLAIVMGVFLFCWMPFFTLTALDPFFNFLSSADVFDALFWFAYLNSACNPLIYGFFYPCFQKAFKILIFTYICGVKKANTLTFE", "length": 336 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5R1F6-1", "protein_name": "T cell receptor alpha variable 5N-4", "gene_name": "Trav5d-4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTYAPTLFMFLWLQLDGMSQGEQVEQLPSILRVQEGSSASINCTYENSASNYFPWYKQEPGENPKLIIDIRSNMERKQTQGLIVLLDKKAKRFSLHITDTQPGDSAMYFCAAS", "length": 114 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5RKI7-1", "protein_name": "Solute carrier family 7 member 13", "gene_name": "Slc7a13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMDIEKKIYLKRQLGYFWGTNFLIINIIGAGIFVSPKGVLQYSSMNVGVSLCVWVFCAVLSMTSTLCAAEIGITFPYTVAHYYFLKRCFGPFVAFLRLWTSLFTGPGVLASQALLLAEYGIQPFYPSCSAPAVPKKCLALAMLWIVGILNSRGVKELSWLQTVSMVLKMGILSFISLSGLFLLVTGRKENVRRLQNAFDAEFPEVSRLIEAIFQGYFAFSGGGSFTYVAGELKEPSKTIPRCIFTALPLVTVVYLLANLSYLTVLSPQELLSSDAVALTWTDRVIPQLTWSVPFAISASLFSNLVTSVFETSRTSYIASRNGQLPLLCSTLNVHSSPFIAVLLDVSMGSIAIVLTNLIELINYLFFVFSIWTVLSVIGILKLRYQEPNLHRPYKVFSPFLFITAAISLSMVLIPLIKSPKMQYIYVFLFFLGGLLFYVPLIHFKLKLIWFQKLTCYLQLLFNICIPDVSDEHVAEEES", "length": 479 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5XHX8-1", "protein_name": "Sperm microtubule associated protein 2", "gene_name": "Spmap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGELGEHRSRSSLLSIPVLDTKTSGGSEYRESDGSLDLQSTLFEDHWLQSSQATTERNTDDPEEEIPPEEMVGEELPEVSNLEDSLRRDLEVEVVGMSHLSINERTTPTTSSAKCRKKKNHRLLELAKPKFNWQCLKDRTGRCCKGHVWISPRKTNLQFCLYWPSVYWTERFIEDTTLTITVPEVSRRVEELSRPKRFYQEYYNNNRTTPIWPIPRSTLEYQASNRLKRLATPKIRNNIWSINMSEVSQVSRAAQMAVPTPRTLRLAKPRAPATLLEEWDPMPKPKPYVSDYNRLLQLATPKALSEKCVPDRSPQWEVLNVTKNAVASSRIISLAQPKIRKDLNEGYNPYYISPASLVAQASPRIYELAVPKHITKKV", "length": 378 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q63550-1", "protein_name": "BPI fold containing family A, member 2F", "gene_name": "Bpifa2f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFQLGSLVVLCGLLIGTSGSLFDIFQNPELDVESVWSEINYRIRYALETMDLDMLADYLSKRGIELKIKDLRILNLNHEVSPNGDEVTLKMPMALNASLSLPARDLTTDVSISMEAITSFAIEKDPKTGRRVLNMQRCSLNTDNTSISLLNRKSNFVNLALDSALYLIKRGLTLPVRRQLCPVLQLIISNTFHPDEISNPQTAIST", "length": 206 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64583-1", "protein_name": "Cytochrome P450 2B15", "gene_name": "Cyp2b15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKGALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFINTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFTGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMFLGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTLKKSEAFLPFSTGKRICLGEGIAQNELFIFFTAILQNFSLASPVAPEDIDLSPINSGISKIPSPYQIHFLSRCVG", "length": 495 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q66X01-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 9C", "gene_name": "Nlrp9c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEKFKLKPLSWTKIKNTSKEDLVTQLYTHYPRQVWDMVLNLFLQVNRKDLSTMAQIERRDKQNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIIDRQYKALLDIFDSESDPATAVVLGTRGKGKTVFLRKAMLDWASGVLLQNRFQYVFFFSVFSLNNTTELSLAELISSKLPECSETLDDILSNPKRILFVLDGFDYLKFDLELRTNLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLELGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQLGVEVFKDLKKNEPLFTLCSNPSMLWMICSSLMWGHYSREEVISSSESTSAIHTIFIMSAFKSIFGLGSSKYKRFKLKTLCTLAVEGMWKQVYVFDSEDLRRNKISESDKTVWLKMKFLQIQGNNIMFYHSTLQWYFATLFYFLKQDKDTYHPVIGSLPQLLGEIYAHKQNQWTHAQTFFFGIATKHVITLLKPCFGNISFKTIRQEIIRYLKSLSQPECNEKLVHPKKLFFCLIENQEERFVSQVMNLFEEITVDISDSDDLGAAEYSLLRASKLKNLHLHIQKKVFSEIHDPEYGSLENFKLDQKFSAINWTMLSILFCNLHVLDLGSCHFNKKVIEVLCNSLSPTPNMPLTVFKLQRLLCSFMTNFGDGSLFCTFLQIPQLKYLNLYGTDLSNDVVEMLCSALKCSTCRVEELLLGKCDISSEACGIMATFLINSKVKHLSLVENPLKNKGVMFLCKMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNKHLSLLDLGSNFLEDIGVNLLCEALKYPNCTLKELWLPGCYLTSECCEEISAVLTCNKNLKTLKLGNNNIQDTGVKRLCEALCHPKCKVQCLGLDMCELSNDCCEDLALALITCNTLKSLNLDWNALHHSGLVMLCEALNHKKCKLNMLGLDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN", "length": 1004 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q675C0-1", "protein_name": "Taste receptor type 2 member 102", "gene_name": "Tas2r102", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPVIYSFATLLIHVEFIFGNLSNGFIVLSNFWDWVIKRKLSTIDKILLTLAISRITLIWEIYTWFTSVYGPSSFAIGMKLQILYFTWILSSHFSLWFATALSIFYLLRIANCSWKIFLYLKWRLKQVIVGMLLASLVFLPGILTQRTLEERPYRYGGNTSEDSMETDFARFTELILFNLTIFSVIPFSLASISFLLLIFSLWKHLRKMQLSSRGHGDPSTKAHTNALRIMVSFLLLYSIYFLSLLLSWIAQKHHSKLVDIIGIITGLMYPSAHSFILILGNSKLMQTSLWILSHLRCRLKGENILNPSGNQVTSCYIFCIANKSVS", "length": 327 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q68FP3-1", "protein_name": "C-C motif chemokine 6", "gene_name": "Ccl6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRHSKTAISFFILVAVLGSQAGLIQDTVKEDRPFNPTIIHQGFQDSSDCCFSYASQIPCSRFIYYFPTSGGCTKPGIIFVTRKRKRVCANPSDQRVQTCISTLKLGPRSGNSAIA", "length": 115 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6EKJ0-1", "protein_name": "General transcription factor II-I repeat domain-containing protein 2B", "gene_name": "GTF2IRD2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVEKSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT", "length": 949 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NXT2-1", "protein_name": "Histone H3.3C", "gene_name": "H3-5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 135 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P3W6-1", "protein_name": "NBPF family member NBPF10", "gene_name": "NBPF10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRSLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAFDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ", "length": 3795 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6UGQ3-1", "protein_name": "Secretoglobin family 2B member 2", "gene_name": "Scgb2b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLALLVTGELGFQRTEACIPFFGVYLGILSGNRIGLHTELAPFDPTVEEKEAFEKIQDCYEEEGLKAKTEDMKLMTTILFSSECRSYYTKEVLKNILVKFSKKLTHGS", "length": 114 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6YCH2-1", "protein_name": "TD and POZ domain-containing protein 4", "gene_name": "Tdpoz4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGELEAKSRGDTQSHEQKLCYRWTISNFSFFVEETEEYITSLVFSLEDNDKMTWCLRVYPTGVDEKNKDYVSLYLILLSCEKGSVWAKFEVCILNAKGEKCNTERIPSFSRIQPHQPFGFEKFITRDSFLSPAQVLTPDDKFTLLCKVSVLQDSFSISGQNPRPAIKVTRCTLENDVGELWENPLFTDCSLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLTNCVEIHDLDPQVFKEMMGFIYTGKVPHLHSHSMACDLLAAADRYGLEDLMVMCEDALCRSLSVENAAHTLIVADLHSTEHLKTQALDFIIVYASEVSKTSGWMSMVESHPRLVAEAFHSLASAQRVFWALPFKQLKWSLRPTQL", "length": 370 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZMA2-1", "protein_name": "Olfactory receptor", "gene_name": "Or1o1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNCTQSPGFILLGLSSDPEKWQLFFSIFLALYLLGFLGNLLLLLAIGADVHLHTPMYFFLSQLSLVDLCFITTTAPKMLEALWTGDGSISFSGCLTQMCLFGVFADMDNLLLAVMAIDRYAAICQPLLYPLLMTPCRCGVLACGSWGIAHCASLVYTLLLSQLSFHSNQEIPHFFCDSRPLLWLSCSDTHLNEFLMMVLSALLGISALLCIVSSYGCIFCAVARVPSAKGRRKALATCSSHLSVVLLFYSTVFATYLKPPSTSHSSGEVVAAVMYTLITPTLNPFIYSLRNKDVKNSLKKLLNMEKPLD", "length": 309 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q70YC5-1", "protein_name": "Protein ZNF365", "gene_name": "ZNF365", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQKAFEESRYPWQESFENVAVCLPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTKCSLFPSLKDTDLVTSSELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSKDRKPFEVVAERPVSYVQTYTAMDLHADSLDGTRSGPGLPTSDTKASFEAHVREKFNRMVEAVDRTIEKRIDKLTKELAQKTAELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVVTFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQASGFVRDLSGHVLTDISSNRKPKCLSRGHPHSVCNHPDLKAHFHPKGRNHLKKAKDDRASMQPAKAIHEQAESSRDLCRPPKKGELLGFGRKGNIRPKMAKKKPTAIVNII", "length": 407 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q71LE2-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 136 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7KR10-1", "protein_name": "Probable cytochrome P450 12d1 distal, mitochondrial", "gene_name": "Cyp12d1-d", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNTLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFLMEPAITFPFKFTDIEQ", "length": 521 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q7M715-1", "protein_name": "Taste receptor type 2 member 117", "gene_name": "Tas2r117", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKHFWKILSVISQSTLSVILIVELVIGIIGNGFMVLVHCMDWVKKKKMSLVNQILTALSISRIFQLCLLFISLVINFSYTDLTTSSRMIQVMYNAWILANHFSIWIATCLTVLYFLKIANFSNSFFLYLKWRVEKVVSVTLLVSLLLLILNILLTNLETDMWTNEYQRNISCSFSSHYYAKCHRQVLRLHIIFLSVPVVLSLSTFLLLIFSLWTHHKRMQQHVQGGRDARTTAHFKALQTVIAFFLLYSIFILSVLIQIWKYELLKKNLFVVFCEVVYIAFPTFHSYILIVGDMKLRQACLPLCIIAAEIQTTLCRNFRSLKYFRLCCIF", "length": 330 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7M719-1", "protein_name": "Taste receptor type 2", "gene_name": "Tas2r115", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCAVLRSILTIIFILEFFIGNLGNGFIALVQCMDLRKRRTFPSADHFLTALAISRLALIWVLFLDSFLFIQSPLLMTRNTLRLIQTAWNISNHFSIWFATSLSIFYLFKIAIFSNYLFFYLKRRVKRVVLVILLLSMILLFFNIFLEIKHIDVWIYGTKRNITNGLSSNSFSEFSRLILIPSLMFTLVPFGVSLIAFLLLIFSLMKHVRKMQYYTKGCKDVRTMAHTTALQTVVAFLLLYTTFFLSLVVEVSTLEMDESLMLLFAKVTIMIFPSIHSCIFILKHNKLRQDLLSVLKWLQYWCKREKTLDS", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7RTZ2-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 1", "gene_name": "USP17L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHCKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEVQWYKMDDAEVTVCSIISVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVGKVEGTLPPNALVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASLQGRTRRAKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TMR7-1", "protein_name": "Monocarboxylate transporter 7", "gene_name": "Slc16a6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTQKNSKLCSRANVYTQVPDGGWGWVVAASFFFIEVFTYGVIKSFGVFFNDLMDSFDESNSKISWIISICVFIMTFTAPLSTILTNRFGHRLVVMGGGLLISVGMIAASFSQRVYQMYISIGIVSGLGYCFSFLPTVTILSQYFDKRRSMVTAVASTGECFAMFAFAPAITALKEHIGWRYSLLFVGLLQLNVMVCGALLRPIIIKGPGSPKAIPLEPRREVQYMLENEKTRTSIDSIDSGVELTTSPKNVPSEAKREQEVRVEQQQTLVVGPKHSQKRAPLLDFSILKDRSFICYTLFGLFATLGFFAPSLYIIPLGISLGIHPDRAAFLLSTMAIAEVFGRIGMGLVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKKGLCQNPHSGENQTDGHRGKALQDIPEDFLEMDLGKCEPRAHMKMDPV", "length": 522 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TN50-1", "protein_name": "Mas-related G protein-coupled receptor member B8", "gene_name": "Mrgprb8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFGLAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIPLLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLLSLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPVTKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCANPIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQNSIP", "length": 328 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TPX8-1", "protein_name": "Oogenesin-2", "gene_name": "Oog2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFYSPPTLMELARQCLLRDEYLAISALKDLPNMMFPVMFKEAFIDGHTKILTAMIPVWPFPYLSVGTMLKNLNLDTLKAVLEEIDILISKPVFSSRCKLREITLSHDLVVVWAGSHEVEGLPEFMEQEKPVENSPGYGTKNKLKVTTELQFMEGHLDECSTYLLQWAYQREDSIHLHCRKLKIYGLTKAAVIEMFKIVHAEYIEDLELSCLCLEYLDFLNPYLKQMSNLLSLTLDEIIYTLNIDDYRNLNEEKVITVISHLPTFHHLQELYVHGVIFIECLRCLKKPLEVLSFTDCDLSQSDLDYLPYCLNIFELRSLHLTDVRLSNLLLEPLGFLLERVRHTLKSLQLMSCEMGETHFNALLPALSQCYQLTVVNFYGNELSLLFLKKLLHHTAKLSQLADELYPAPQECYDNRDVVLSHRLENFCSELLDILRAIREPKKVTFGTIKCSKCGGSYVYDLETQCCFFEKNPPWA", "length": 476 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TQY5-1", "protein_name": "Olfactory receptor", "gene_name": "Or4k38", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSNRTVSSEFIFQGLCSSRQLEIFLLLPFSILYLMAVVGNLFVVILIIIDHHLHSPMYFLLANLSFIDFCLSSVTTPKLTIDLLKENKTISFVGYMRQIVCVHFFAGGEMVLLVTMAYDRYVAICRPLHYSSIMDRQKCIWLVVISWIVGFVHAISQMLLILDLPFCGPRVIDSFFCDIPLVMKLACMNTDTLEILINADSGILATTCFILLLISYTYILLTVQHRSKDGSSKALSTCTSHIIVVLLFFGPIIFIYLWPVSITWVDKFLAVFYSVITPLLNPAIYTLRNKDIKNAIKKLISHK", "length": 305 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TR72-1", "protein_name": "Olfactory receptor", "gene_name": "Or8k25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKYNLTIVTEFILVGITNHHEFQVPLFGLYLIIYLTSLVDNLGMIILTIVDSRLQTPMYFFLRHLATTDLGYSTAVGPKMLRNFLVDQNIISFYACAIQSSFFGMFIVCEFFILSAMSYDRYVAICKPLLYTVIMSQKACWILVTIPYLYSIIVSLLVNIKIFTLSFCGYNVISHFYCDALPLLTLACSNTHEIEAIILIFSAFNLLSSLLIVIGSYLLILMAILRINSAEGKWKAFSTCGSHLTVVIVFYGTLIFMYLQPTFTHSIDTGKVISIFYTQVIPMLNPLTYSLRNKDVKDVLKKPMEKVHNLFS", "length": 313 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TSF0-1", "protein_name": "Desmoglein-1-gamma", "gene_name": "Dsg1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENTLHSQLLQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAVKNLQLCIGVRNVAEFHQSIISQYRLTVTLITVTVLNVVKGCVFQPGSKTFIVDSRMEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDSGIITLRNRVTMEQYERLNKRYEGTVLSIHDSLQRTCTGTIIMVLCGFWTTTEHPTTSTEKPVTLSITPNVDNVHFGPAGIGLLIMGFLVLGLVPFLLISCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPGGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDPSWPPQSTEPICPQHMEQLASGHPSISPHFGKTTVISENAYPSGPGVQHPMLIPDPLGYGNITVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPALRDGTNVIVTERVIAPGSSLPNSLTIPNPRETSNVVVTERVIQPTSGMIGNLSIPP", "length": 911 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q803M0-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "ppp1r3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPIELAMSLYLSSDEFLNPRASKYSRPLQPCLNQCKSSKLSFSSLKEQSEFNGVSRALMIPGRAKKHVSFADHKGLALTVVKIFSEFDDPIDIPDNIDNFFTSSLTVSEGKDKLTLDFDQPSADYLKFRQRIENDHVCLEHCMLKEKSIMGTVKVKNISFEKSVKLRITFNTWKNHTDVECQYVKDTYTGSNRDTFSFEASLPEQVPSHERIEFAICYEVNGDTLWDNNQGKNYRIIQSALRKSSNESNGGHQQYSQSDWDIHFDRYGSPRCSRGIFPHWPSYVGYEDIGPYY", "length": 293 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80SW5-1", "protein_name": "Embryonic testis differentiation protein", "gene_name": "Etd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEKNPEAVPRPPEQNTELVPPKKSKSKKPANILIYLIDRHLGRPRNDMDLFEWVWTLK", "length": 59 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80VJ6-1", "protein_name": "Zinc finger and SCAN domain containing protein 4C", "gene_name": "Zscan4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIIQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSAPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSENDPREVPGLQSRQEQPISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80VT8-1", "protein_name": "S100 calcium-binding protein, ventral prostate", "gene_name": "S100vp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQNLTSTEQEIMELLMILQEFSVKKIDKLDVQEVKRLFREELPNFLKAMDEATKNKILNDKGKEMPFDEIWDMIGRMALEYRKKNSNALKD", "length": 92 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80XZ1-1", "protein_name": "Polypyrimidine tract-binding protein", "gene_name": "Smptb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRNSPPAAEGNGSKRFKGDSWGTRDPSRLVHILRLPSCVTEGEILCLALPFGEVSNLLFLRAKNQAFVEMSTEESANTMINYYTWMPPVLRGQPVHIQFAHYRELKVSSSPSQEISLSQAGDSREATASSLVAVPGQAAASGQTAVPSQLGAQPCLPPEDSYQAGTVALAPPASAVDTELVVAWQSPVLRILVENYFYRVTLEVLHQIFSRFGTVLKIITCTKNNRFQALLQYAHVMSAERAKLFLDGQNIYDACCTLRISFSGLTNLMVKYNNDKSRDYMRPDLPSDDSQPSPVQVQNMASALPAPAMSSASPYASIALPHTFAIPQAAGLANPEVFKTLHPQAIQEVAMASSSSSSSTAAAAVGAAEIAAAAVPGAEGSMVTSGSPGVGSPVLLVANLNQEKVTPRSLFILFGAYGDVHRVKILFNRKENALVQMADGSQAELALRHLNGHKLYGKALCILLSKHQSVKLPREGKEDQGLTKDYANSPLHRFKKPGSKNFQNIFPPSATLHLSNLPSLVSEEELKNLFSSNGYAVKAFRFFPKNHKMALIRMGSTEEAIQALVDLHGHLLGQNHHMRVSFSRMTI", "length": 588 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q810J1-1", "protein_name": "Pregnancy-specific glycoprotein 22", "gene_name": "Psg22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVSSELLSNGWTSWQRVLLTASLLTCWLLPITAGVTIESVPPKLVEGENVLLRVDNLPENLRVFVWYRGVTDMSLGIALYSLDYSTSVTGPKHSGRETLYRNGSLWIQNVTREDTGYYTLQTISKNGKVVSNTSIFLQVNSSLFICGRPSPPALLTIESVPASVAEGGSVLLLVHSLPDNLQSLLWYKGLTVFNKVEIARHRTVKNSSEMGPAYSGREIVYSNGSLLLQNVTWEDTGFYTLQIVNRYWKMELAHIYLQVDTSLSSCCDDFNSVQLRINPVPPHAAEGERVLLQVHNLPEDVQTFLWYKGVYSTQSFKITEYSIVTESLINGYAHSGREILFINGSLLLQDVTEKDSGFYTLVTIDSNVKVETAHVQVNVNKLVTQPVMRVTDSTVRIQGSVVFTCFSDNTGVSIRWLFNNQNLQLTERMTLSPSKCQLRIHTVRKEDAGEYQCEAFNPVSSKTSLPVRLTVMNE", "length": 475 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q863C3-1", "protein_name": "Gastrin-releasing peptide", "gene_name": "GRP", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRGREVPLVLLALVLCLAPRGWAAPVTAGRGGALAKMYTRGNHWAVGHLMGKKSVAESPQLHEEESLKEQLREYAQWEEATRNLLSLLQAKGARGHQMPPWEPLSIHQPAWDSEDVSNFKDTGPQHEGRNPQLN", "length": 134 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q869X2-1", "protein_name": "Probable polyketide synthase 17", "gene_name": "pks17", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTFNNIKDENNDDIAIIGMGFRFPGGGNNPYQFWNQLSNKMDGISKIPTEKWSRSFYEQKYINNEYGGVLKDEEWKNFDPLFFGISPKEAPIIDPQQRLLMTTLWEAFEDANIKPSTFRGSDTAVFIGMMNTDYQRCQFRDISYVNPYITPGTAGSFISNRLSFSFDLRGPSMTLDTACSSSLNAVYLGCQAIANGDSKMAIVGGVNGIFDPCFSMTFSGLNMLGHKGQCRSFDAGADGYIRSEGGGVCILKKYSDAIKDGDRIYCVIKGGSSNVDGYNAKTNIIQPSMKAQGENIEIALKKSGVNPSDIYYIEAHGTGTPVGDPIEIEAISRIFKDNHTPDAPLYIGSVKSNIGHLESAAGIASLIKVALSLKNRSLVPNIHFEKPNPLIKFEDWNIRVVTDEIQFPINKLINMGINCFGLSGSNCHMILSEAPINYDELLKTTNNNSTSSSSNDDKKEYLIPFSANCNISLDKYIEKLISNQSIYKDTILFKDFVKHQTISKSNLIKRKVITASDWDDFLNKRNETTSTSSLTSTISAPASSTPVIYVFTGQGPQWRDMGKALYETESVFKDAIDHCDKLLANYFGYSILQKLLSLESEDSPEIHHPILAQPSIFLIQVGLVALYKSFGISPSIVVGHSFGEIPSALFSDVISLETAVKIVYYRGLAQNLTMGTGRLLSIGIGADAYLEKCALLYPEIEIACYNDPNSIVITGSEQDLLGAKSTLSAEGVFCAFLGTPCSFHSSKQEMIKEKIFKDLSDLPESNVPCVPFFSTITGSQLSHKGFYNVQYIYDNLRMPVEFTKAISNIFNFIEENESYKNAIFLEIGPHPTLGFYIPKCKPSNSTITSKPIIVSPLHKKKEELTQFKLAISTLYCNGVEIDFASGQQLLPTSSSSGGGDISSFKESTNKLPRYQWDFEEYWDEPNQSKMVKRGPSNNLLGHDQFAGNTLMELFIDIDKSAHQYLKGHKIKGKYLFPGSGYIDNILRQFNGQDITIFNLEFSNPFFLKDGVQHHLQTSITPTTKGEFKVEFFIKDNRNSTKWTKTSNGRIGLFKHNPKNNKLDIEKLKSQCSFTTLTKSEVYNKLLLLSLPYGPTFQRVESCSIGDGCSFFKLSMSPCSEFDKDFLNPSIIDCAFHGLLVLSEGPQEIVFDRLQDMKFYSSNVPSTRPQFIYAFAKFDKIEGNSTHGSLNIILEDGTLLISIKNVKCTSLIRLKKQSIKYPSQNVYSHHWQSKDSPLTLIENQLIEEKSSESKINFEKLLNDKLFNYYLIRLLNQSIKSEFIEFDYKTSTVDTLDIGSKNAKLLEKIQSILNPIDSLDQSIDITSLKQAIIVKSSFKNEIKLVEKSIKRIVSLLKGGESEHFSPSNPSSPNDTPRNNSNNCSSKNNAASSDDADDDTNNEETINQLNNEPFNFSNSQFISNQNQLISKTIVNSFDRLINSIEIGEKKLIKIIDLSSIYQNYQLSKLLLLQLNQLLINLSNNNNIEIEYTIPSNTKNIDSITEETKSISNVLNIKYRSFDLQDDLESNGYLNSNYDLIITSLLLVSTNSIDSNEVLSKLYKLLLPKGQLILMEPPKGVLSFNLLFANDFKQSLEIKSEQEIKSLIIYCGFTKIETNLNTKDDEEQQQPPPPSILIVQAEKRDIESMSLTFSSDPKSLNSSYSNCIFIVSKEQKENPTSYIQEYFDITEFFCQNATIIEADDSELLTKTIESGVGKNDIIFFLVSLEELTIENYKQVTMQYTLVNQILLRNNLSTRFALLTYDSQNGGKNYLGSSLIGTFRYFLEFRSLNIFSIDVDKDSIDNLTLFLRLVDLSTIGDRETIVRNNKIFVQKIFKEPKLLSPSNNYEKNTNNLFLYSNSNLDFSFQSKEKLLHGCVEIKVMSTGINYKDSLFYRGLLPQEVFSKGDIYSPPFGLECAGYITRVAPSGVTRFKVGDQVVGFASHSLSSHVTTHQNKIVLKPENISFNEAAAVCVVYATSYYSIFHIGAFIADKESILVHSATGGVGLASLNLLKWKRNQLKKHGNSEISNDASIYATVGSKEKIDYLQEKYGDLITAIYNSRDTEYCDEIKQQSAQGGVDLILNTLSGDYLSSNFRSLSQVGRIMDLSVTQLVENDSLDFSNFKYHVGYNTIDLDRATKYNSKIIRDILTEVFDAISDGSLENIPVKVFPAIQVKTAIEYINERVHIGKIVVDFENFEQDILKPALQEKENPIQLNKVKKLEHTCDTLNNTILITGQTGIAVHILKWIISGSVLNSNKSQQQVTDFIILSRSSLKWELENLINQTKHKYGDRFRFHYKSVNIADLNSTRTAIDQVYSSCKNVSPIKSVLHFATVYEYILPENITQTVIDNTHNPKAVGAINLHNLSIEKDWKLENFILFSSIGAIIGGSKQCAYSSANLVLDSLSNYRKSIGLASTSINWGGLDAGGVAATDKSVASFLEGQGILLVSLSKILGCLDSVFQPSNSHLSNFMLSSFNIDNLLSSAPQMKRKMDHHLTNYKTSSASSDDSLGDSGSTQAKVISTISELLSIHPSKLNLDTRLKDYGIDSLLTVQLKNWIDKEFTKNLFTHLQLSSSSINSIIQRISSKSTSTSTPNPTNTSKQTATKKT", "length": 2604 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q869Z5-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHLTPKPNVLNVYGAGTPNFVKVQILLEEKNIPHVYHKIDFSKNEQFDPEFLKFSPNNKIPAIVDNTVEPNGISVFESAAILMYLSEKHQFTDLYADFKTDPALHAKHLEFLFFQMSGVGPMTGQLGWFLRQPEPKNTQAIERYSEEVKRLYRVLDKILSTNTWVAGEQYSIADISLLGWALYFLKGYYDDHITREQFPNVYRWLDLAAKRPAIIKVLETIQPKQK", "length": 227 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86AE3-1", "protein_name": "Probable polyketide synthase 9/36", "gene_name": "pks9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGNLKNINLKEKGVAIVGIGFRIPSGNNENSISSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFKEWKSFDPLFFGINPSEAPLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSTIDYLHTNKHQDSVLKNAIAQSTSAISNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSNMSIVGGVNLILDVDIIKAYSILSMLSKTHGKCKTFDESGDGFTRGECVGVVVLKNLQDAVKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNDKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRNNEKPVSMMINNFGVTGSNCCLLISEFKNNNNFKENINLESQSVNDRVLIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNFLYQRSVVIASNSNELFENISNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGFSVWEKVKTIKDDDLTSIHDPIFAQPALCMISVSLFELYYHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYQRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTTMLGSLSSFHTSSQQCTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLNNEIVFIEIAPHPTLLFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNQSINLPLYQWDEELYFTQAQTLEQHRKEGPPIDHLGTSNSYNSPFNNSYRTSIDIKNKPFLYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHGNDIPPKYNIKEIIENKCNLSKLTKNELYTHIKSKTGLNYTGVFQGVTECYIGGDCTLSVVSLESQTNSFLNIPILDTCLHGMIGLSNDQCQIVFDKAIGFKYYSSNIPANLKDYKDSVYVYSHLKSKSVDSFFGSIIVMLSDGSVLYEIEEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSPIPTPSSFKSIIYENDFFHSALNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSLEENDDAYFEFNEVIIKSSRIISKLLFPLESDNDNEDLPQSLFQNGLMDKIYKCRYLRKKNQMISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIIALLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGFNVIYRPLKIDESLIETQSINPSYYDFVIMSNVLHVVKNIKQAVEQMYQLLTPNGQLLFLEPPYKSVLNDSIVGSFEQWWSFTDTDIRKDRCSMSQQSWCQLLKTCNFKDIAMSKECIFVGIVIHAQKPPISLLNSQPKRDNIIIYGGGNPIFVENIKLYSNSKSLIQIETIQEFNQLLSQSTITNDSIIYFIKTLETLSLDNFKQITLEYIEINRKLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLNTLDFDYDSTQNYINSNNKDMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNYKKIQIKPSNLSHNEASSIPIDYLTSFMSLFNIGSLNIEDNESILIHLGSDGFGLSTFEILKWKGFNSNLFVTVNSYETKRYLQDNYGDFITGIYSNTDKSYVTEINKKLIKLGSKKKGVDLILNTLPSDFMDSNFKLLAKYGRIIDLTSNHLNQSEFLKNINFKYNHGYHNFELSLIQKNKIHKCLYEISNAFENGELKTIPIKEFTNLNIKDAIKYITNNKIEKITVSHDHEIYSDIIYRSLDEKEFSILKSNYQINSNNLGKNILVTGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINETKLSNNNIKFHFKSVDIGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAINLHNQSIKRNWKLINFVMASSAISLIGSTDLCTYVCANALLDSFSKYRESLGLPSTCICLGAIESTGFVSKNESVSVFLDGGGFHPTPINQVLGLLDLQIQNAGKFTNSMLSNFKPSKFKNNQQTSLFLKFDYLMNLKNNSEETKIENTGNKNIDELFIEKVSELFSMDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTISTSMKMILNSLMKNNQNIDDNNKDLPSNRIDYWKNEMKFEESIKPISNEIQSRNNSEKIILLTGTTGFLGGFLLFNMVRLDSCKLIYCLIRNKSKSNNPLDEIINNLKYHQLYEKLNQSQISKIIPIIGDLSMNKLGLSNDDYETISKNVNLIINPGADINQKSSYQDCKLVNVNGVKEIIKLSLSSLKQRIPIVNFSSFSVFFNQSLDKNFDESVLPSIDNIDNLPTEYMKSKVVGEYILLEASKKYNIPSILIRPPSIFLNPETGIGHISDFSLLSIQSCYELGYYPNQFENDFILINTITWLSNNITNIIMNDNCWTDSKMNIYNVHGKQIQSSLIIKPLEKHFNCKHINTNDWIDMVNNSNKKSCIKLKSFHSLDIILKSENNRYKPNENQSISLSTKSLLESMGSYNTDLEITDKMIISHINQIFNLNETI", "length": 2931 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86AF8-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFSKFSIKENKPKKVKSNSSKGFNNNEINSTNNNNNNNNNNNNNNNDSDNFINNNDSNNNNNFNNNNNNNSNNINNKTEDSNDISLLINQFIGSSPAPSTCSGSDKFSIKPKKIVTPSKRKNSTSGSDIIDFNNCNNNNNSKSNSDSNNNKYNNSNSNNNSCNNTNNGNERKMKGYDYGNNNSNNNYSSSSRDYNSNNNSSPRDYNNNNNNNNNNNNNNNNNSNNNSPRDYNNSRDYNNNNTNNNSSPRDSNSNNNRNSSSRDFSNNNSSPRDYNNSRNSNNSFLNNNNNNNNNSNNSNDNSPRDYNYSSSNSSPRDYNNNNDTFSKKRNNVGNSILEIKSNPTSPRIKPIMVWPRSSPRIVNKLPPVQSLVDLTEIEMIDDNNNNNNNNNNNNNNNNNNNNNNNSNNNNNKSGSNNNFSDSDSDKDNYNNNNNTNNNSFNSDSDNYNNSNNNNSNSNSNSNSNSNSNSNNNNNNNNNSNNNNNNNNNNNSNNSNKSNNNFSNIKILEKRRKSINEISDNLTTRNIEEIDSKMAHEFEHPFLEKLIFAGQRPPFVECDDYFLKRYKNQFQYYLDISMKSIINTRDIGEGDDDDEINSVPFKCTLCSYEYDEENNNENTNGFIDEADKIYNRSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNNNNNNNFYDKKYFKNNYFQHLLSKHLNQIKAKGIQDTNVYNDEANIPLGSKKCDHLECSEIILKNEFTKHIKKLHHHHKDEDIDICPRCKILKKSIQKRIVKFSKKKQEKDDDNNSKPVSNKVATISHNPSPNNIDKDINNNNNNKNNKNNTNNLENDNNDNSSNNNYLENEEEPEIVFQDIKPNNNNNNNNNNNNNDDNNNDNNDNNDNENNNDNNNDNENSNNNNNNS", "length": 901 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86BK9-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Dmel\\CG32971", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDSKDEALLKSFKTQLKDNVLSMLLNFEELLKLVSPRTPGQITNDTEQELNAFEMQVRAGNFVRAGEALIKLVHDVKEYQIIYDYSNIEEEMDRQSEAMHAKVTEYDQTLIKMVKDLEEELSELEYEYYEKSGGPDLDSKDLLV", "length": 145 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q86IJ5-1", "protein_name": "Uncharacterized protein DDB_G0272718", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPPHGHHHHHHGHHGHHEHITITPVYAPPQVVQPIYAPPPVVQPVYVQPPVVYPQATIVLETGHHHGHHHHHGHHGHHDHHHHGHHGHH", "length": 89 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86IV6-1", "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNFFEKKNNNNNNSSNNNNNNNNNKNNNNKNLDKNNSSDRNNNNNGDKNNLKPTQKSLIDLWFQVDDEDEEYELSSLSNDGGSSFNSFKVNNRDTSIGSDIYSKTITPSSLALSTSSLISSTLTPPTQSPPFSKKNEKTSSFLNSPSSQKSKSNNSNVKEKLSPQYSSSSQLSDFFKKKKRPLLDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTISSLNTNSNNNSSGSSNGSSSSSSGGGNKSSNNKKQKVSQSTSSTSLKEKQSQQSILSYLNPTPSLPTPIFDKPIERSDSNLATSSFSKLNFDDIPLDDEELSQKINTPSPKLILKNTFSSTPTQKSPSLSSTPPNKIKITDKKLPNSSSSSSSPPPSSAKSKLSHRSQSSPLSPLITNLNQNKSNEFDDINFNFNIPSPLKEINNKPNIKSNSKETLTPLTQIFHSSSPPPSIIIESSPSVCFSPTPTKNQSPTLSNLSPTFSFLSDTSPVKSPSQLFEFTFDDPLSPKLISSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNTFISKNNLINLFNEQSNQENVSTTTTTTTTTTTSTSTNNNNNNRYERVLIINVFYEVTQIFNNSNDKIHKKTLSGFSESIGESREIQLLDEWIYTPVRPGDIVNVIGEFDDNGEIIINNIQNLLILHPDILITGTELGGSLTCTRRSVLKEQIRVGNSNSSTVPIFGSIVHEIFQECLKNNRFHLDDINTFKQEIIGKSTFQLGLSSLGETQDTALNHLENWLPTIDKFAKTFILPSSSSSSASSLKKNLIEINSEKWHLSISKILEIEENIWSLMYGLKGKIDSSLEIKLVKQQQDEKQSKQSKQSKKKKQQTTSPNNNNNNNNNNNNNNNNNNNNNNNNNNGPTTCYLNVPFEIKTGKPYQIPYISHSSQVLIYTLLMNDRYDQDIEMGILYYLKSQEFKSVGLNYGLLHPILFERNQIRSLIVSRNLLAYFLNLNSQPLLKPNPILPEMLRDYHSCTKCYSIDPCVLYHKAIENGDQFTSSLGDLFLEKTNHLSSIHINYLKNWNKIISLEYSIKNNKRKLIWNKSRKFGEKNNSCIGELILISEEYSEITETFSYRFRVNPDKLLNSSISEGDYLLISVEDKYYGMGSGQLSNIINDIITITCREKLSEPPSLLSDYTTPNCNNNDPSYFGNYRNKPLIYIEYEDADQQQQQQQQQQQQQQQQQQQQQQQSQKQQKQKQPNFTQLRGLNNYVNNSKLTPFKWRVDIDEQLSGLSIVKSNLFNLFLKENQKLRSLIVDLEAPIFDKLEQENYWKSIDFQNDYPLLNIDQRNAIIKTLSAKDYSLIHGMPGTGKTTLVISLIHILWRLGKKVLITSFTHTSLDHLLLKFNKQYPNIEMLRVASSLNQIDPSLHRFTLEKQSFGNITQSKQYLERQQLVATSCLGINHQCLLKMQFDYCIIDEASILSQPISMGPILKCKSFVLVGDHHQLPPIVNNKEAGKLGLDISLFKQLSTSHPSSVSNLYHQYRMCNSIMSLSNHLIYNNRLVCGNQSISNLSLQTNYYHNNNNTTHIDLLDHINNWPQIICNPNSSVIFVNTDQLNNSTESSNGDLFYNQTEANIVAILTNCLINKLNINQSQIGIITPIRFQLNFIKKSILKYLSIENNNNNNNNNNNSNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQNNNQNYLKKIENLDILTIDKFQGKDKDCIIISFVRSNEKKEIGELIKDWKRMNVAFTRAKKKLIFVGSKSSLSKFPFFLDFFEFLDSKNWIYNLNNKIQF", "length": 1838 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86JI5-1", "protein_name": "Probable polyketide synthase 5", "gene_name": "pks5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDMKLNDIENENFINQMKGVAIVGIGFRIPSGNSENSISSPDDLFNNLKNGFDGVSSTSERWSDNYHKLGEISSPNAGLLPLNEWKSFDPLFFGINPSDAHHIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSTIDYLHANKHPDLILKNAIGFSPSTLSNRISYCFDIHGPSLSIDTACSSSMNAVTQGYHSILNGTSNMSIVGGVNFVIDVETIKGFSYLNMLSKTHGKCKAFDESGDGFTRGECAGVVVLKKLDDAIRDGNRIYCIINGISSNIDGNGIADKANFYSPSKQSQFNNINLAFKSTNGKISVNDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVVSLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNRNNEKSVSMMINNFGVTGSNCCLLISEFKKQDYESYENNIGSINKNILVPFSANSPKSLDQYQSKIKNIINNQFNFIDFANNQIYSKSNYLYQRSVVIANNSNDLVNKILNKKHIQTKNPIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGYSVLEKLRSIGDDDTTSIHDPTIAQPAMCMFSVSLFELYKHWGVNPSFILGHSLGEIPTSYCSGMIDLDTFCYTVYQRSIAQTKTHGNGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSILQLNIESKKSKVPTFSTVTTNLFNESDPFNSQYVYDNIINPVKFTQTISNIYKHIESNQLDNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNQKINLPLYQWDDELYFAQTQVLEQHRKEGPPIDHLGLSNSYYSPFKNSYRTFIDIKNKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQCLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHTIEMPPKYNIEEIIKNKCTLARLTKNEIYTHIKSKTGLNYTAMFQGATECYIGVDCTLSVVSIESQTNSFLNIPILDSVFHGNISLINDQCQIVFDKVHGLKYYSSNIPNDYKDKSVYVYAKLKSKTSDSYSASFTVLLSDGTVVYEIDEAFSKSLIPIKELLKIEYPNDELFSINLQPKDSPIPAPSTFKSLIYENDRFNAEPPMVENLFQYISTIFYKNIINRCPEINIDIIKSLSIDEIISNFSKISKHERLFKYVFETIKENGILNSLEEKDDTYFVFNEVLIKSSRVISKLLFPLENDNDNEDTPQLLFQNGLMDKVYKCRYLKNKNQMIAHIIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIVTLLQENPNYQVEIEYTWSDISPAFIVDTKNKINKIIKGAGITNGLNVIYHPLTIDESLVELQSIKPSYYDFVIMSNVLHVVKDIKQAVEQMYQLLIPNGQLLFVEPPYKSIICDSLFGSFEQWWAFTDTDIRKDHCCLSQDGWYKLLKWSNFESIEMSTESKFMGSVIQAQKPSFTSLINQQPKYDNIIIFGNNCPNFIDNIKPFSNFNEFIQIETIQEFDQLINKSTITNDSIIYFIKSINQLSLDNYKQATLEYIEINQKLLQINSLCKHVLIVNDSRKTNYLASSIVGAARYFDEFQQLKLHTLDFDYDSTQNYLISKNNKMVQFINNLIDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFEQQDNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINNKDYLVYSGLEGSVNSNTPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSNIIVNHERIQIKPSNISHIEAASIPIDYLTSFMSLFNVGCLNIEDNESILIHLGSDSFGLSTFEILKWKGFKSNLFVTVNSDEIKQYLLNNYGDLITAIYSNTDKGYVSQIKNKLIEQGSNDNGVDLILNTLPSDFMDSNFQLLAINGRIIDLSNDHLNQSEYMKNVNFTLNRGYHNFDLMSQRNSRINRSLLTISKAIENGELKLIPIKEFSNSDINDAIEFIIEENRIDKIVVSHDHEVYQELYAKFSNENDFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINEILNENQEIINIHSIFHFAFTQIACKVQEINMKHLDISHGAKTMGAINLHNQSIKRNWKLINFVISSSIASLVGSTDQCSYVCANALLDSFSKYRVSLGLPSTSINLGAIESTGFVSKNESISVFLDGSGIIPTPINQVLGLLDLQIQNPGKFTNSMVAKFNPLNFSNNEQINLLLKMDYIFNLHSNGYTKVKESAGSKNVDELFIKKISDLFSIDESKINKDIRLIDYGADSLVIVQLKNWVDQEIGFNLITIQQLQNNTINVSIKIILNFLKKINK", "length": 2512 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86KS1-1", "protein_name": "DNA cross-link repair 1 protein", "gene_name": "dclre1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDDEDDINLYITRSKNNENKKTNKNRLIDNNIQKTKTTTAVLTTRTTTTTTTTTASTQLKWDYGDEDDDDYSAPKDIDEEQSSKQFNYQNNQIVVKQDHDDYSAPKDMDEEQSSRQFNYQNDQTLVKQDDDHDDYNEPKDIDSQSLIDEDCDFEFDNSDFFFDDGTTNNNDNNNKNNKNNNNNNNNNNNNNNYNNNNNKNYKRKYYQSYNNSNNINNNNNNNNDKFEKRLSDLKKTGKEEAKKRGYQVRKTPTKEKKIPPSFKVIDGTNFLVDGFQYKSEDFTHYFLTHFHSDHYVGITKTWSFGNIYCTEETGKLVSHKLGVDQRYIVKCEWNKLIEIQGVKVAFLDSNHCPGSALILFIIPLRNKDGEIIGEESILHTGDFRYNQSMNNYPLLKGRTISKLYLDNTYCDPQYVFPPQPEIIKQVASIVRKENDGETLFLFGTYVIGKERILLEIAKQEGKPVHVSNEKYAILCCLSTCLDINKFTTNELITPFRAVTMSMLSYHNMLSLLDSSNNKYKRVIGFRPTGWTQAKKSITYLNRGPTTFYSVAYSEHSSFNELRDCIDHFRPTQIIPTVDCDSPIKVKNILAHFSDLYEKKKQLTIASFFSAQPVTNFFQSFFKSKSEPIIDEDNKKLIPITTTTTTNINTLTATDTTTTKIKTSNTLIKDEFTDDLIWDCSDDLISDRKLLTQSDNSSALCKIEKEENFNDLSENNNNSNNNNNNNNNNNNNNNNNNNNNNNNNKLIIENDIKEEIIDFDDPVFISQQKWIEKQIYNNNNNSNNNNFTTPTKTNGNLSNNAKLNLTPTQTQTQTPTQNNKKQKTTNVSPTSYNSNNSSQQSGLKRSKSDPNVKKNQLQTSQPPSQSLITSFFQKCASPTSLFSATPPTPSITTTSNQSTKNKNSTTTTSTSTSNNKPFKN", "length": 920 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86KX6-1", "protein_name": "TNF receptor-associated factor family protein DDB_G0272348", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEFELEDITIEQSSFTNNNSNNNNNNNNNSNSNNNNNNNNNNINNNNNHNNNNKNNSNNKNEINNQLDIPISNLVVDKENISKKYFCTICSDLLVNSFHADKFKAVQCKNGHYTTCLNCWEKHLEKKKNCIQCGVDVESIESLSSNLLVTQKFTTFKIHCPNSFFDTIDFIKDEVNGCKEIIQINELEEHLKECQYGFISCKNCEEFSKLPFQEFTQCPDFRKNTKEQHDLICPYVKISCEYCGDIINKINKESHNANWCQEITIKCLDCHLPFKKKEINQHQKSFCPETIIQCRYSKGGCNAMIRRSKLSQHLTEGDNHHQFISNILNQQDLKINELELKNTEFCLLLNGQNKKITELEILFKELNDSILIQKQQQKQQQQQQQQQQQQQQQQQQQQQSQQQQSQQQQQSQQQQQSQQSQQNNNSNSHFINNNNNNINNVQMSDSPNGGSLPQAVYKNKWVISNYSEQEQQGISKDYIKSPLFKIGNSTFFLKWFPFGKKKLNYCSIFLYKTQDDKSIIVNYYIHLVNNQISDEVYEKRGCQKYDSENGSAGYGSSQFIKRADLLNDANGFLINDSITIEIEIFATEEILPLQS", "length": 595 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BI41-1", "protein_name": "Syncytin-B", "gene_name": "Synb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGFWVLCFVLFPSSLSYPESWMPLVNLTHHILRDTNSSLFSNCWVCLSTQTQRSLAVPAPLSIWTDTPMKLHLTYSVRPFSGSFSISDIERRLRLFRPLTASYSFHNPDRRAIAFLQLVSSTGIFRIITRITSVIYPHKDRFFESAQRPLWGPLFTETVLRSQAPLCISRFFKVSAYATFVGNLSASLCNYTMHISPSTSHENLDLSTTHTFKQAMKRPDAKWKNPLRFSGPPSLIFSKPAYYPCPTDIKHCHTSPATPWMHCPQAPFGTCYNLTLFEPDNSTHPVTMSVNPTHFKVKLQGHRDPYPLSHYQPLTGAALSGQYSVWENEITVQENWDITSNIFSHLLSFSYAFCLNSSGVFFLCGTSTYICLPANWSGVCTLVFQYPDIELLPNNQTVPVPLFASVLSSDSVLRPKRSPHLFPFLAGLGISSALGTGIAGLATSTLYFQQLSKVLSETLEEIAASITTLQNQIDSLAGVVLQNRRALDLITAEKGGTCLFLQEECCFYVNQSGIVRDAARKLQERASELGQHSDSWGQWPDLGRWLPWLTPFLGPLLFLFFLLTFGSCLLNCLTRFVSQRLGSFVQDTAKRHVDSILQNFQYKKLPQDSPDEDTIPT", "length": 618 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BYG0-1", "protein_name": "Tetratricopeptide repeat protein 24", "gene_name": "Ttc24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSSRQYGLSDVLRALEESRKLADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALALCQHEPSSVRERLVAKLADAMRTFVAQEKIAQARFLPSAPGKLQTSRKAKTSARVQSSAEDAQESQWEGEASEGGHEKKEMEGLVNTATVLGPQRQNRATTHLPSGGPSPSGEEYPFIIAPKKLRVSRSSTWAKEALGRNFQRTRIQSGLCSIM", "length": 334 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C1N8-1", "protein_name": "Alpha-defensin 22", "gene_name": "Defa22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKLVLLSALVLLAYQVQTDPIQNTDEETNTEEQPGEEDQAVSVSFGGQEGSALHEKLSRDLICLCRKRRCNRGELFYGTCAGPFLRCCRRRR", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C1P2-1", "protein_name": "Alpha-defensin 21", "gene_name": "Defa21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLVLLSALILLAYQVQTDPIQNTDEETNTEEQPGEDDQAVSVSFGGQEGSALHEKLSRDLICLCRNRRCNRGELFYGTCAGPFLRCCRRRR", "length": 93 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C5Y2-1", "protein_name": "Mitochondrial sheath formation-associated protein", "gene_name": "Misfa", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVLGWMLFVGLATYMGTFPEAMPPTLKWKERLPGQENKARRRIQALEEELLL", "length": 53 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CDW1-1", "protein_name": "Protein FAM228A", "gene_name": "Fam228a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADTKTSKCDEHFSVEKLKEWPEPESVSLMELLAREDIDEAVHAVLFRENYVVKRLDTYLQHLAVFKERRKEMLHKKWVENVVQPLQQRITDKITSYRRPGKNQVKYEHCLKQTNKPTKVSSSCLFQKQQEFREAKGTSYQHGRGKTHDTQKEAKETEKGLSFTPFSLRPHCSSPRERQRASARLMQSKPGGRNRYKGASSEKPVFTLKSHLPKEEKTVSRSQLVFERQFRASRLSQDIKEAEKKGLVVGTGPQRPRSWAAADSVPRPSLVGRRVMTAEILGEHLVSLHQAARSGLQWP", "length": 299 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CEK3-1", "protein_name": "Serine protease inhibitor kazal-like protein, minor form", "gene_name": "Spinkl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSTWIKFLFILTLVLLPYSVFSVNIFAGPENVIKEPNCTMYKSKSECSNIAENPVCADDRNTYYNECYFCIEKVVEKLKYRYHGICIYK", "length": 90 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZP1-1", "protein_name": "TBC1 domain family member 3", "gene_name": "TBC1D3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K072-1", "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "Reep4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSWMICRLVVLIFGMLYPAYASYKAVKSKNIREYVRWMMYWIVFAIFMAAETFTDIFISWFPFYYEFKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDACIVQAKERSYETMLSFGKRSLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSIPDTPVPTYQDPLYLEDQVPRRRPPIGYRPGGLQGSDTEDECWSDNEIVPQPPVRPREKPLGRSQSLRVVKRKPLTREGTSRSLKVRTRKKAMPSDMDS", "length": 257 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MP30-1", "protein_name": "Uncharacterized histidine-rich protein DDB_G0274557", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIKYFLVLLVGFLLVLPSIVNPYRKGVTITNQQPKINIYQLDVNNPHNPNNNPHNPHNPNNNPHHPHHLHHHHHHHHHHHHHHHHHHHHHHHHHHPHHPHHHPHHHHHPHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHPHHHPHPHPHPHPHPHLHPNPHPHPHPHPHPHPHPHHHPNPNPHPHPHPHPHHHHHHQEASECLSYQGNRNRLFIKRDY", "length": 233 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8NG83-1", "protein_name": "Olfactory receptor 2M3", "gene_name": "OR2M3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARENSTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYLLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYTSLLGSECFLLAVMAYDRYTAICHPLRYTNLMSPKICGLMTAFSWILGSTDGIIDVVATFSFSYCGSREIAHFFCDFPSLLILSCSDTSIFEKILFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLLVVGMYYGAALFMYIRPTSDRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSGE", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8NGV6-1", "protein_name": "Olfactory receptor 5H6", "gene_name": "OR5H6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLYLCFIFQRTCSEEMEEENATLLTEFVLTGFLHQPDCKIPLFLAFLVIYLITIMGNLGLIVLIWKDPHLHIPMYLFLGSLAFVDASLSSTVTPKMLINFLAKSKMISLSECMVQFFSLVTTVTTECFLLATMAYDRYVAICKALLYPVIMTNELCIQLLVLSFIGGLLHALIHEAFSFRLTFCNSNIIQHFYCDIIPLLKISCTDSSINFLMVFIFAGSVQVFTIGTILISYTIILFTILEKKSIKGIRKAVSTCGAHLLSVSLYYGPLTFKYLGSASPQADDQDMMESLFYTVIVPLLNPMIYSLRNKQVIASFTKMFKSNV", "length": 325 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R264-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r215", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNWNNIIHTIIFLSLTGPGIVGNMLIFIRHIYMPALGTEKKPVDLIVIHLAFSNMITICTTGIKDIATVFYFRNFLGDIGCKAVVFLARMARGLSICTTCLLSVVQAITISPRTSLWTKLKPQTACQIIPFILVFWIFNGLISSNLLSYIKGGSSLNRSVAATFIGHCYMLQSRHTIKWIFLSLMTLRDVIFQSLMGWSSGSMALNLYKHHKRVLYLYSSRFANNSPPEIRATWSVLILMTCFLLFYWADFILSFYHGFTVTHESILLNIKVFLELGYVSFSPYVLISRYIHPPNVFHAH", "length": 300 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R272-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r220", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLQFIKKTIFLFMTMVGILGNMSVSVHYMFSWWGSPEKKPIHLILTHLTFTNIILLLAKGLQKTIIVFGLRNFLDDIGCKIIVYLERVARGLSICTSSVLTVVQAIIISPRASGWRRLRPKSAWHILPFFSFFWILNAFISVNLIHSIRSKGMNTSQHKNSDDYCYLTPESQKIKWIVLPLMVLRDAVFQGAMGGASGYMVFLLHKHHQHVLYLQNSKLLYRTPPELRAAQSVLLLMLCFLFFYWTDCALSLFLSLSLGDSSLMINIQGFLTLGYAIFSPFVLIQRDGLIPVCWHAQ", "length": 298 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R278-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r213", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLALRNYIQINTPWCMCLFVTPLTPCLPEYWDPDSLRVEGPTESSLRHNTASCTLKNTIMQNVQFRSMSSITDAFFKMYLHTRKEEMILKILKEITFLIMTVLGILGNMSVSVNYMFSWWGSPEKKPIHLILIHLIFTNIIILLVKGLPKTIAAFGLRNFLDDIGCKIIVYMERLARGLSICTSSLLTVVQAIIISPRASGWRRLRLKSAWHILLFFLFFWILNALISVNLIHSTTNTRLNVSQLKSDDNYCYFMLPIQKIKWIVLPLMVVRDAVFQGAMGGASGYVAFLLHKHHQHVLYFQNSKLLYRTPPELRAAQSVLLLMLCFVFFYWTDCAFSLFLTLSSEVNILMVNTRDFLTLGYATFSPFVLIHRDGLLVECRHVQ", "length": 384 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2A9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r229", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDFGNLAMGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNDLFDDVGCKLIMYVRRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIEFCHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAFYTLSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFVMSRDFTVSRFCFTCIGNLKLP", "length": 306 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r178", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHDKSLKTTDDMTLQILLLCQFVVGTVANVFLFLHNISPVLTGSKQRPRQLILSHMSVANALILFLTSFPDMMAFAPRNSPTHLKCKLEYFSRLVARSTNMCSTCVLSIHQFVTLVPVNRGKAILRASVPNLTSYSCYSCWFFSVLSNIYIAIKVTGPQITDNNTDSKSKLFCFTSGFSVGIFFLRIFHDGTFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNFICIIFYTFSIDSRLFMSHFSKVFAAGFPTISPLLLIFRDPKYPCSVLFNC", "length": 304 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r64", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKTLKTMEVLALQILLLCQVVVGTVGNIFLFVHNFSPVLTDSRLRPIQVILINLAVANAFMLLLFAYSYDLIDFVPRKPPTDLKCKLAYFFNMVAQGTIMCSTCLLSTYQFVTLVPGNWARVMFREISPKVVSYCCYSCWLFSVLNNAYMPMYVSGPQKTHNDSDSKDNWICSISGVSVDMNFLRFSHDIIFIGIMAWTSVSMVIHLNRHHHRMHYLHNPNQINRGHAETKAAHTIMMLVVTFVSLYILDCICSLFHISFVESRLWLIDVIELLHLSFPTVSPFLLICRDPMGPCSLLFIVGLEIHVTVGAITEEQ", "length": 320 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r59", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMLALQILLLCQVVVGTVGNILLFVHNFSPVLTDSRLRPIQVILINLAVANAFMLLLLTYSHDMIDFVPRKPPTDLKCKLAYFFHMVAQGTIMCSTCVLSTYQFVTVVPGTWARVMFREISPKVVSYSCFSCWLFSVLHNAYIPMNVSGPQKTHNDSDSKGNSICSISGVNVDMHFLRFSHDIIFLGIMAWTSVSMMIHLNRHHQRMNRIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCISILFHISFVESRLWSRHVIKVLALSFPTISPLLLIFRDPRGHCSLLFSVGLEIHVTGGVITEEQ", "length": 310 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2C0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r62", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVLALQILLLCHVVVGTVGNILLFVHNFSPILTDSRLRPIQVILINLAVANAFMLLLFAYSYDLTDIVPRKPPTDLKCKLAYFFHLVARGTIMCSTCVLSTYQFVTLVPGTWARVMFSEISPKVVSYCCYSCWLFSVLNNAYMLMNVSGPQKSHNDSDSKSNSICSISGVSVDMNILRFSHDIIFLSIMAWTSVSMVIHLHRHHQRMNHIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCISILFYISFVESRLWLRYVTKLLALSFPTISPLLLIFRDSKGHCSLHIMSVWKST", "length": 300 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R4R9-1", "protein_name": "Protein phosphatase 1 regulatory subunit 14C", "gene_name": "Ppp1r14c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVVTGGGEAAGGTSGGGARVFFQSPRGGTGGSRESSSHSGSSREDSAPVATVAAAGQVQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEEEEMPDVEIDIDDLLDADSEEERASKLQEALVDCYKPTEEFIRELLSRIRGMRKLSPPQKKSV", "length": 164 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R4V1-1", "protein_name": "NFAT activation molecule 1", "gene_name": "Nfam1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESWLLRRGARVRCLHPPSWLPAWCFLCLLPVPQTLQLTGLVSLTHTSLPIMVSLANTDVFFSCRIEDFTRLQRDLPVKLFHTDIHGRRRWEKQINCQHRPGMENHTRDCMVKLSQANTSATGIYYFIVEGEETYQSDGVVILVRDTVYQPPAFKVQEALMLGFTSLMSVLGVLGTALLLWKKKQISVLGKHTAKTCSGLKSTVGTTKPPAESVYTSLQRRETEVYACMKEETGSPVFSQSPATKEKLNRFEDDNEFNLVYENL", "length": 264 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8T277-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma", "gene_name": "prkag", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MWYPGDEDEEFTSIIENIEKKETQEIKIKTEKLRQASLNQLPIEQSEGVGGGELSEYNNNTTNNNTPTNTTTTTNTNTTTMNNSNNNNERILSTSNGFDIRLPPNSIEQPSPSFISSSQDGVLTVDPLAVDGEKGNKESQSPPNGDNQILNNNNMFFKDITSLPSTDNKSSTNTNNNNNENPLKQTISSSPSKSTTTTTTSTSTTTTPSLSSLSSNNNNNSNSNNNYINHSSISTVSEGLENLNLKSGIKKIDSETEKYIEEGKQVFVNFLKGHTCYDVIPISGKVVVLDTKLAVKSAFYALEENGIKSAPLWNSEQHDFTGMITVSDFIDILLYYYKKPKSNNIFQDMGIHRIETFWREISVERPSSLISTEPETNLYDAASLLLCYKIHRLPVVDKKDTNSILHILTHSRILAFMMKSFPQLPEKLLSIPIGSLGIGTFATVVTVMTHTPLVEVLELLSEKKISAVPIIDSETSKIVDVYSKSDVTLMSKQGILSPSDLNLPVHQVLSTFTKLWQRPEQIYTCTRFDKLGDVIERCIKKRVHRLVCIDSSKKVEGILSLSDILNYLLNDVKSINH", "length": 577 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VEU4-1", "protein_name": "Olfactory receptor", "gene_name": "Or14j2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVENITTMRGFLLMGFSDNHELQILQALLFLVTYLLGSAGNVIIITITTLDPQLQSPMYYFLKHLSILDLSSLSVTVPQYVDICLTQSGYISYAQCMLQIFFFTGFAWGEVAILTVMSYDRYVAVCLPLHYEVIMGPSKCRWAVTAVWLSSVIPGTLYIASIFSIRFCGDRIIHQFFCDVPQVLKFSCSDDYLVTVGVADFLSAVAFACFIGIVNSYVHIFSTVLRMPSAESRSKVFSTCLPHLFVVLLFLSTGIFAYLNPTSDSPTALQFLVSIFYTVLPPTLNPVIYSLRNETIKSVIRKLLLSSKFTG", "length": 312 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VFX0-1", "protein_name": "Olfactory receptor", "gene_name": "Or5b101", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENRTEVRCFILVGLTNDPSLQLPLSITFLLIYIITLIGNLGLILMILLDSRLHTPMYIFLGNLSLVDFCYSSTVTPKVIAGFLTGDKIMSYNACASQMFFFANFGDVENYLLASMAYDRYVAVCKPLHYATTMTTHMCASLVIGCYICGFLSASIYTMDALSLSFCESNVIHHFFCDVLAVMIVSCSDSHVNELILIYVVSFNMFFALIIILISYMFIFTNILKIHSSAGYHKAVSTCASHFTAVSIFYGTIIFMYLQPSSSHTMDTDKIASVFYTMVICMLNPLVYSLRSKDVKSAFTKIVLRSK", "length": 307 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VY69-1", "protein_name": "Vesicle-associated membrane protein 723", "gene_name": "VAMP723", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAQQSLFYSFIARGTVILVEFTDFKGNFTSVAAQYLENLPSSNNKFTYNCDGHTFNDLVENGFTYCVVAVDSAGREIPMAFLERVKEDFYKRYGGEKAATDQANSLNKEFGSNLKEHMQYCMDHPDEISNLAKAKAQVSEVKSLMMENIEKVLARGVICEMLGSSESQPQAFYIKRTQMKRKKWFQNMKIKLIVLAIIIALILIIILSVCGGFNCGK", "length": 217 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8VZ67-1", "protein_name": "Uncharacterized zinc finger CCHC domain-containing protein At4g19190", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGEGEGSGIRLSKRFAGGKVTGGSLEVDYKTKSGTAWSHSFLNQKPWHPLSYPNQRRKWIAEQTHAQHDRRAEEVAREFAQEQEFFKQAALISKKEREKIETMKAVSFMYVRPPGYDPESAKAAEYKDEKHKGQGSSTQDPVADDNVGSRPEESQGGGERTQERKKPRPKDVFGRALPTEEEFEVLKNAPRMETGIPGRVKPFAVEVRNVKCLRCGNFGHQSGDRDCPLKDAVMPNEELRLKRDDPLTAIIAHTDPSEPLKWELKQKPGLSPPRGGFDPDDPNQQIVAEDIFDEYGGFLEGSIPIEILKSMSSDKKRKSKKNKRHKKHSSRTVEETDESSTGSEDSREKRGSKKRKKLKKKSKKQYDSDSLSFEGSGSDSYRLSRRRHTKHVDPSASLKSEVYHQGNSHREKHYYDEKHQKRKEIVDRPSASSDDSDYYRSNSSRKKRSEDDYKSHHRERKQVHSNDPVSEKSQKQHYSESGKIQRVEKEHRYDERRHRYVDMESENRNRSEKKPRYDDRDSEKHHRSVKGKEKHVYEASDDPEEFSDRYRSTKKTESDSESNRRSRKKKHELSSEEEEGESRKHRYSTNRRRN", "length": 595 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q91V82-1", "protein_name": "Beta-defensin 8", "gene_name": "Defb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIHYLLFTFLLVLLSPLAAFSQKINEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK", "length": 60 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q923B3-1", "protein_name": "Neurotrophin receptor-interacting factor 1", "gene_name": "Nrif1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYREIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNSFPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEASRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKFRVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAAEVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNRELTPDSPIPVVKPIHDPNTNDLSRNGTQSTVFESILEDGVKEMHSIESNQVGNLQEKGHPQKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIRKQQKDSVEWQGRSGSTPVTHGSSIKKQQQGSEQGKPGTSRDPITLTVPAKVYQKATGSEESIFMDSSDAMVPDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDNSLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKNHLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIHKGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGERPYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL", "length": 828 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q924S2-1", "protein_name": "Inactive 2'-5' oligoadenylate synthetase 1C", "gene_name": "Oas1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENGLCSIQARELDEFICDYLFPDTTFLTELRADIDSISAFLKERCFQGAAHPVRVSRVVMGGSYDEHTALKGKSEAKMVLFFNNLTSFEEQLKRRGEFVEEIQKHLCQLQQEKPFKVKFEVQSSEEPNSRSLSFKLSSPELQQEVEFDVQPAYDVLYELRNNTYAEPQFYNKVYAQLIHECTTLEKEGDFSICFTDLHQNFMRYRAPKLWNLIRLVKHWYQLCKEKLREPLPPQYALELLTVYVWEHSNKNQEKVTTAKNFRTFLELVAYYKNLRIYWTWYYDFRHQEVCAYLCRQLKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWMQSSCFRNCDMSFVPTWDLSPERQECAFQ", "length": 362 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q925U0-1", "protein_name": "Oocyte-secreted protein 1", "gene_name": "Oosp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPFVGLLGLLLLLSFMKTCADDWTAISLQCADHWFHLRIRPTIFHNIFMEPDEVFLGIGCPVTTTWPNDTYEFIYRTYSCGIANKVLCDVTLLKTQLTYISKNASLQAEMSLSCVMHNQSPHFCEAESRGDFTGDPPGWTEDMRARRDEQTVPMVQPNLSTSSEDHHVSTEPWASETSRSEAAEVPSFMDQNFSVFHFSRM", "length": 202 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q94490-1", "protein_name": "Ubiquitin conjugating enzyme E2 B", "gene_name": "ubcB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAAHKRLQKEITDMLKTPPSWCSAHLVDDNLQKWKATVQGPEGSPFEKGVFSMDIDIPADYPFKPPTLKFTTKIYHPNIKTSDGAICAEVFSTWSPQLKILDVLTTIRSILTDPNPDNPLETEIAQQFKTDRNAFNKTAKEWTKKYAK", "length": 148 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q945S5-1", "protein_name": "Vacuolar cation/proton exchanger 4", "gene_name": "CAX4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSISTESSSNLSLLENGGGGSDKPTAETSRRVRRTVSASSLIRKRSDLKLISRVRWEFMRRILTNLQEVLLGTKLFILFPAVPLAVVAHRYDCPRAWVFALSLLGLTPLAERISFLTEQIAFHTGPTVGGLMNATCGNATEMIIAILAVGQRKMRIVKLSLLGSILSNLLFVLGTSLFLGGISNLRKHQSFDPRQGDMNSMLLYLALLCQTLPMIMRFTMEAEEYDGSDVVVLSRASSFVMLIAYLAFLIFHLFSSHLSPPPPPLPQREDVHDDDVSDKEEEGAVIGMWSAIFWLIIMTLLVALLSDYLVSTIQDAADSWGLSVGFIGIILLPIVGNAAEHAGAVIFAFRNKLDITLGIALGSATQIALFVVPVTVLVAWTMGIEMDLNFNLLETACFALSILVTSLVLQDGTSNYMKGLVLLLCYVVIAACFFVSNSPSSKLLF", "length": 446 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q96AK3-1", "protein_name": "DNA dC->dU-editing enzyme APOBEC-3D", "gene_name": "APOBEC3D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ", "length": 386 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99N64-1", "protein_name": "Germ cell-less protein-like 2", "gene_name": "Gmcl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C7P4-1", "protein_name": "Putative zinc finger CCCH domain-containing protein 9", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADAGDNQQEAERRSDETESRSIKEPKEKEDEDENPQDQIQSKERMRQSSPYPVRPGKKDCQFYLKNGLCRYRSSCRFNHPTQRPQELPVRICKHIMDRNVAEPMYQDWRESESERRFDERTQRTFGDERTQRRYGIEYSGARPEKRSKIVPDFQMRDPRHHDTEWRFERERMERIERQRREAEENLQEQRQRDSIERQRREAEENLQEQRQRDSIERQRREAQENLQQQRQRDSIERQRREAQENLQQQRLQDMPENHNVDDQQNLQEQRRISIEKERTEARLRLEQIRPTVSFPINEFIRAVVLLRELIENWDDKAWKK", "length": 321 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9C8M4-1", "protein_name": "DNA-directed RNA polymerase subunit 12-like protein", "gene_name": "NRPB12L", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLQQSETDDKQPEQLVIYVCGDCGQENILKRGDVFQCRDCGFRILYKKRILDKKETRIGV", "length": 61 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CQK8-1", "protein_name": "Small proline-rich protein 2A1", "gene_name": "Sprr2a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK", "length": 83 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9CWP4-1", "protein_name": "Lymphocyte antigen 6K", "gene_name": "Ly6k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL", "length": 154 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9D541-1", "protein_name": "Coiled-coil domain-containing protein 7A", "gene_name": "Ccdc7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCAKHPSTISMKLTSVPELPYKKGLLNSSPKPKEKHNAKSKYGKNESMVLRSPPTGESIVRFALPIPLSKTKDKISADEMVRRITTNLKMVVSNLEDTYGACYDNGEKAAEKSEAEGLSIGDDVSSFLLCCSQFTSQLEEAVKEECGALESLYKWFQQQVNQMEEISKDQSNLEELQSDGKTASLNIVQIAKLARKFEDFKSRLKTRKEVMQTKNEDKEIMAETLKHYGLMEKQIEEFITSHSALESQTETESQSGTPSVTTRMARMIKIFENQSTMLEKALNDQQTIESKYKQLETDFQMLIMEKTLLEAEIRRLREIERVKSAAKEEQTKKSGKSEKKKFKEKEKNLSPNREFKSIEELLQIQKEAELLKTEKKTLQGQLKWALEEAERNKTQLEFVLHQKMEMFKEESKTKVGQSQNKSKVKIEDSKDSLPKKSDTQLGGQRKDQISSDQSKRPKKKQLADIDPSAVEDFPPETFKSFTVMPLIEEHRESISSQPKEEMAKASEQSEAEDIEGPLEIPSESSNEDDDLLPEDESPMMEQVTDVGRYKSIYISAEPIDTMSLISRTQSEMETLEAINYDNVLNEGEEQDKKIGKDSDTGRKSKRKRSSKIRKLSTHEEESDIVHYEEATKAKVPSKKRASDPYGDEAYESRGSVSKAQTYTKKQGTHQRGRGSASDAYGDEAYESRGSISKAQTYTRKQGTHQRGRGSVQEEESDTVHYEEVTRAKVPSKKQASDPYGDEAYESQGSVSKAHTHTKKQGTHQRGRGSVHEEESDTMNYEVPRKSKISSRRKGFALPITHQVEMHSSESQGSISKSNTETKKQGTHKRGRDSDADGARTPVSQGSDSKADTERKKHRSKEESTISKDSIPVLDEVQDKTFEHQESGLRLEVQAKKLTFSSQNIHNEESATDIKVEYQNVPSSSQVQLKKQKPLGGEIFTTHFVVPAESHAQLYQTHTPETQIERGTTSGTARLTTIPVEHPKKEASPDNLFPEKKLYITRAPTQTKKQYPPWDAKAETQKKTVKEVQGISEPQTKLNPTMSGIILHLDMDRVVETDLENLEETIVPHVLRSELEIGTDAKNMPETPTSREAVRTEAKGNQDVTISIAKGMKLIGKLKDQHGLSSFASKDTISPGKSLIKSSRDNQDDSLLETKPQENTSDKYHPSKTFPTKVINMLPFSEKSLGSTSANVDVAPKPVYRASRGRSRISKALQQLLKTSEHLKPTSTKNQNADLEKHLYISVRSANKHTQKDKKHGQSNNQKLKKQGALSSTKKQKHKEQPKTETIVENNDKFDDNLMMTTSSPNIKIIKELSKTLNLDGGDIELSDFVFKTASAAKKLENKGPSKTKNLNKESSRDIHILHLTTSAIRTLLLDEEAKIRSLEKKLMKQSTILQKSVSSMKKFMFEEPSRETKMKRKKREKRKIVVKSPHILPITTTQKHTIKEKSEISNLEKPIVRGTDILKKSTSARKKRVLKGKSKSATLPKKCDNFPFDLVRSSSDSSKQEVEEQPKPGNVDKKVSDDSYSPDISTTPTKKHTLKGQSKSRTIYEKGVDLPNNLVLSKSASSIQEFEEQPQPGNVDKKVSDDSYSPDISTSPTKKHTLKGQPKSENSDEKGIKRPNNLHMSASVARKRLLKALSTIP", "length": 1642 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9D5R2-1", "protein_name": "WD repeat-containing protein 20", "gene_name": "Wdr20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEGRGKETNEIKTHFTTREGLYRLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQTGNGNRLCFSVGRELYVYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSDSLFLVAHSSGNMYSYNVEHTYGTTAPHYQLLKQGESFAVHNCKSKSTRDLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSAELHGTMKSYFGGLLCLCWSPDGKYIVTGGEDDLVTVWSFLDCRVIARGRGHKSWVSVVAFDPYTTSVEESDPMEFSDSDKNFQDLLHFGRDRANSTQSRLSKQNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARAHANVMNATGLPAGSNGSAVTTPGNSVPPPLPRSNSLPHSAVSNAASKGSVMDGAITSGVSKFALLSLHDRKERHHEKDRKRNHSMGHISSKSSDKLNLVNKAKTDPAKTLGTSLCPRMEDVPLLEPLICKKIAHERLTVLVFLEDCIVTACQEGFICTWARPGKVSKFQP", "length": 567 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9DAF8-1", "protein_name": "Uncharacterized protein C4orf51 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTHFLYLTPEILLPFSPLTSTEFELIRRKAQQLWQDETRWSASSMTTYSGSYREKQLDEATCNRLAQRVGQPQFEYKPTPLPGSSAYNTLPGHAGSQEAADGKGRLPDIASPSRDSPLNIKHKVAHQIWGSEVPCPTFLAYRGLRMSPCMQPKKPGFELLMSYRNRGKALLKRLQRQWDYESKLGSSEDSGTDRFSSNTSGSSGRKFK", "length": 208 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EPV9-1", "protein_name": "Beta-defensin 5", "gene_name": "Defb5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIHYLLFAFLLVLLSPLAGVFSKTINNPVSCCMIGGICRYLCKGNILQNGSCGVTSLNCCKRK", "length": 64 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EPX4-1", "protein_name": "P2Y purinoceptor 12", "gene_name": "P2ry12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM", "length": 343 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ER80-1", "protein_name": "Receptor-transporting protein 4", "gene_name": "Rtp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLFPDDFSTWEQTFQELMQEEKPGAKWSLHLDKNIVPDGAALGWRQHQQTVLGRFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEACSLNSHGRCALAHKVKPPRSPSPLPKSSSPSKSCPPPPQTRNTDFGNKTFQDFGNRTFQGCREPPQREIEPPLFLFLSIAAFALFSLFTR", "length": 249 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FFP9-1", "protein_name": "Serine/threonine-protein kinase SRK2H", "gene_name": "SRK2H", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDKYEVVKDLGAGNFGVARLLRHKETKELVAMKYIERGRKIDENVAREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEAEARYFFQQLICGVDYCHSLQICHRDLKLENTLLDGSPAPLLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKHADVWSCGVTLYVMLVGGYPFEDPDDPRNFRKTIQRIMAVQYKIPDYVHISQECRHLLSRIFVTNSAKRITLKEIKKHPWYLKNLPKELTEPAQAAYYKRETPSFSLQSVEDIMKIVGEARNPAPSSNAVKGFDDDEEDVEDEVEEEEEEEEEEEEEEEEEEDEYEKHVKEAHSCQEPPKA", "length": 360 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9FLZ3-1", "protein_name": "SNF1-related protein kinase catalytic subunit alpha KIN12", "gene_name": "KIN12", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGSSEKTTNKLVSILPNYRIGKTLGHGSFAKVKLALHVATGHKVAIKILNRSKIKNMGIEIKVQREIKILRFLMHPHIIRQYEVIETPNDIYVVMEYVKSGELFDYIVEKGKLQEDEARHLFQQIISGVEYCHRNMIVHRDLKPENVLLDSQCNIKIVDFGLSNVMHDGHFLKTSCGSPNYAAPEVISGKPYGPDVDIWSCGVILYALLCGTLPFDDENIPNVFEKIKRGMYTLPNHLSHFARDLIPRMLMVDPTMRISITEIRQHPWFNNHLPLYLSIPPLDTIDQAKKIEEEIIQNVVNIGFDRNHVVDSLANRIQNEATVAYHLILDNRNQNSVPNDPFQSKFKEISDGIFNSTLPVQNITSHVGHSFSALYGLKSNVKDDKTWTLGLQSQGSPYDIMTEIFKALQNLKICWKKIGLYNIKCRWVRSFAYYKNHTIEDECAIILPTVIKFEIQLYKVREGKYLLDILRIDGPQFIFFDLCVAFLRELGVL", "length": 494 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9FVV4-1", "protein_name": "DEAD-box ATP-dependent RNA helicase 55", "gene_name": "RH55", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSSPPNTIIEEAPPRFSELKPPLSEDIIEALDRSGFEVCTPVQAETIPFLCSHKDVVVDAATGSGKTLAFLLPFIEIIRRSNSYPPKPHQVMGVIISPTRELSAQIHKVARAVRLDFAKCREVEADMNTLEEEGANLLIGTPGRLSDMMKRMEFLDFRNLEILILDEADRLLDMGFQKQVNYIISRLPKQRRTGLFSATQTQAVADLAKAGLRNPYLKCEADQKSSQLVHLLIENKNKKLVVFFMTCACVDYWGLVISKIPSLKSISFFPTHGKMDQKGRDTALASFTEASSGVLLCTDVAARGLDIPGIVYIRSLAIKDREVLEKGLKAFVSFVRAYKEHQCSYIFSWKGLEIGKLAMGYGILSFPYISEVKQDRIGIVGFTPVQGITFEDIKFKNKSREKQRQQNLLARKDKLQQEKRGKRKKSSKEAVDDSNKASRKRKLTGRQRQTIQTAQDEEEMNLRL", "length": 465 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JI02-1", "protein_name": "Secretoglobin family 2B member 20", "gene_name": "Scgb2b20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACLPFFEGYASVLSGSRVWLYQELQAFNATAEEKVALEKIQDCFSEERIRNILLEPKIMEAMVASPECLSYYGLDNIRSILDYISKLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JJQ7-1", "protein_name": "X-linked lymphocyte-regulated 4B", "gene_name": "Xlr4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKIKGRPPKQPKVTPALPSNDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHLKNLQAIKCCRRKAIIEEARKLMDYLEKRVTEETVHVNKQEAKDGVQSSLLSLLIS", "length": 215 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JLV9-1", "protein_name": "Prolactin-2C5", "gene_name": "Prl2c5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPSLIQPCSWILLLLLVNSSLLWKNVASLPMCAMRNDRCFMFFEDTFELAGSLSHNISIEVSELFTEFEKHYSNVPGLRDKSPMRCHTSFLPTPENKEQARHIRYEALLKSGDMILDAWENPLDYLVSELSTIKNVPDIIISKATDIKKKINAVQNGVNALMSTMNGDEENKNPAWFLQSDNEDARIRSSYGMISCLDNDFKKVDIYLNILKCYMLKIDNC", "length": 222 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LJY9-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 18", "gene_name": "CYP705A18", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATLISVDFQHCFMYIILLCLFSLLCYSLFFRKPKGTRVGCDLPPSPPSLPIIGHLHHLLSSLTHKSLQKLSSKYGPFLHLRIFSVPIILVSSASVAYEIFKAHDVNVSSRGAAAIDESLLFGSSSFIYAPYGDYWKFMKKIFATKLLRPQVLENSRGVRAEELKRFYRRILDKARKNENIEISKESAMLMNNILCRMSMGRSFSEENGEAERVRGLVGESYALVKKIFFAATLRRLLEKLRIPLFRKEIMGVSDRFDELLERIIVEHKDKLEKEHQVMDMMDVLLAAYRDKNAEYKITRNHIKSFFVDLFVGGTDTSVQTTQWTMAEIINNPNILQTLRKEIDSVVGKSRLIHETDIPNLPYLQAVVKEGLRLHPPGPLLIRTFQERCEMKGFYIPEKTTLVINAYAVMRDPDSWEDPDEFKPERFLSYSRSGQEDEKEQTLKYLSFGGGRRGCPGVNLGYIFVGTAIGMMVQCFDWKIEGDKVNMEETYGGMNLTMVNPLKCTPVPRTQPFSFTSNLEILSS", "length": 524 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LSY1-1", "protein_name": "SKP1-like protein 8", "gene_name": "ASK8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSTKKIMLKSSEGKTFEIEEETARQCQTIAHMIEAECTDNVILVLKMTSEILEMVIEYCNKHHVDAANPCSDDDLEKWDKEFMEKDKSTIFALTNAANFLNNKSLLHLAGQTVADMIKGNTPKQMREFFNIENDLTPEEEAAIRRENKWAFE", "length": 152 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LTG5-1", "protein_name": "Callose synthase 4", "gene_name": "CALS4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNQPNRGQILQTVFSHFFPVASPDSELVPSSLHEDITPILRVAKDVEDTNPRSLFLQDLDIKSVDDSINILSGHSHALDKANELDPTSSGRDVRQFKNTILQWLEKNNESTLKARQKSSDAHEMQSFYQQYGDEGINDLLNAGAGSSSSQRTKIYQTAVVLYDVLDAVHRKANIKVAAKILESHAEVEAKNKIYVPYNILPLDPDSKNHAMMRDPKIVAVLKAIRYTSDLTWQIGHKINDDEDVLDWLKTMFRFQKDNVSNQREHLILLLANVQMRQTQRQPNLLDDRALDTVMEKLLGNYNKWCNHVGLESSLRFPKDKQQKVVQQRKLLYTGLYLLIWGEAANLRFMPECLCYIYHHMAFELFEMLESKGSKKKYKPKNPTYSGKDEDFLTKVVTPVYKTIAEEAKKSGEGKHSEWRNYDDLNEYFWSKQYLDKLGWPMKANADFFCKTSQQLGLNKSEKKPDLGDGCVGKVNFVEIRTFWHLFRSFDRMWSFYILSLQAMIIIAWNETSESGGAVFHKVLSVFITAAKLNLFQAFLDIALSWKARHSMSTHVRQRYIFKAVAAAVWVLLMPLTYAYSHTSIFIVAILIYLSPNMLPEMLLLIPSIRRTLEKSDFRPVKLIMWWSQPELYIGRGMHESAWSIYKYMMFWIVLLTSKLAFSYYVEQIKPLMGPTKEIMSVPMPGYWLPEFFPHVKNNRGVVITLWSPVILVYFMDTQIWYAIVSTLVGGLYGAFRHIGEIQTLGMLRSRFQSLPGAFNACLIPNENTKEKGIKLAFSRKCHKIPNTNGKEAKQFSQMWNTIINSFREEDLISNRELELLLMSCWAYPDLDFIRWPIFLLASKIPIAVDIAKKRNGKHRELKNILAEDNCMSCAVRECYASIKKLLNTLVTGNSDLMLITTVFTIIDTHIEKDTLLTELNLSVLPDLHGHFVKLTEYVLQNKDKDKIQIVNVLLKILEMVTKDILKEEIKRLHLLLTVKESAMDVPSNLEARRRLTFFSNSLFMEMPGAPKIQNMLSFSALTPYYSEDVLFSTFDLEKENDGVSILFYLQKIFPDEWKNFLERVKCGTEEELDAIDYLKEEIRLWASYRGQTLTKTVRGMMYYQKALELQAFFDLANERELMKGYKSAEASSSGSSLWAECQALADIKFTYVVACQQYSIHKRSGDQRAKDILTLMTTYPSLRVAYIDEVEQTHIYSKGTSENFYYSALVKAAPQTYSTDSSDSGHMLDQVIYQIKLPGPPIIGEGKPENQNNAIIFTRGEALQTIDMNQDYYIEEAFKMRNLLQEFLEKNGGVRYPTILGLREHIFTRSVSCLAWFMSNQEHSFVTIGQRVLANPLKVRFHYGHPDVFDRVFHLTRGGVSKASKVINLSEDIFAGFNSTLREGTVSHHEYIQVGKGRDVGLNQISMFEAKIANGSGEQTLSRDLYRLGHQFDFFRMLSCYFTTVGFYFCSMLTVLTVYVFLYGRLYLVLSGVEKELGNKPMMMEIILASQSFVQIVFLMAMPMIMEIGLERGFYDALFDFVLMQLQLASVFFTFQLGTKFHYYCKTLLHGGAEYRGTGRGFVVFHAKFAENYRFYSRSHFVKATELGILLLVYHIFGPTYIGLFTISIWFMVGTWLFAPFLFNPSGFEWHEIVEDWADWKKWIEYDNGGIGVPPEKSWESWWEKDIEHLQHSGKWGIVVEIFFALRFFIFQYGLVYQLSAFKNKYSSLWVFGASWLLILILLLTVTVLDYARRRLGTEFQLLFRIIKVSLFLAFMAIFITLMTCRLILPQDVFLCMLALIPTGWGLLLIAQSCKPLIQQPGIWSWVMTLAWVYDLVMGSLLFIPIAFMAWFPFISEFQTRMLFNQAFSRGLHISRILSGQRKHRSSKNKD", "length": 1871 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LU95-1", "protein_name": "Pyruvate kinase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEMLLGGQATNGALRSKTKIVCTLGPASRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILCAVMLDTKSPVIRTGFLKEGKPIQLKQGQEITISIDYKIQGDSNTISMSYKKLAEDLKPGDVILCSDGTISLNVLSCDKYLGLVRCRCENSALLGERKNVNLPGIVVDLPTLTEKDKEDIMQWGVPNKIDIIALSFVRKGSDLIQVRKLLGEHSKSIMLMSKVENQEGVMNFDKILENSDAFMVARGDLGMEIPIEKMFLAQKTMINKANAHGKPVVTATQMLESMTVSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFIDYDILHKKTLGMVSLPLSPIESLAASAVSTARSVFASAIVVLTRGGYTAELVAKYRPSVPILSVIMPEIAECSDSVAHVARRGLIYRGIIPVVGCSARDSTEEMIRLAIGFAKTKGICKTGDSIVALHKIDGSSIVRIVSVE", "length": 497 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LX08-1", "protein_name": "Annexin D6", "gene_name": "ANN6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASLKIPANIPLPEEDSEQLHKAFKGWGTNEGMIISILAHRNATQRSFIRAVYAANYNKDLLKELDGELSGDFERVVMLWTLDPTERDAYLANESTKLFTKNIWVLVEIACTRPSLEFFKTKQAYHVRYKTSLEEDVAYHTSGNIRKLLVPLVSTFRYDGNADEVNVKLARSEAKTLHKKITEKAYTDEDLIRILTTRSKAQINATLNHFKDKFGSSINKFLKEDSNDDYVQLLKTAIKCLTYPEKYFEKVLRRAINRMGTDEWALTRVVTTRAEVDLERIKEEYLRRNSVPLDRAIANDTSGDYKDMLLALLGHDHA", "length": 318 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LXS7-1", "protein_name": "Citrate synthase 1, peroxisomal", "gene_name": "CSY1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEISERARARLAVLNAHLTVSEPNQVLPAIEPWCTSAHITAAPHGSLKGNLKIVDERTGNEYQVPVSEHGTVKTVDLKKITTGKDDKGLNLYDPGYLNTAPVRSSISYIDGDEGILRYRGYPVEELAEKSTYTEVTYLLIYGNLPSQRQLADWEFAISQNSAVPQGVLDMIQSMPNDVHPVGALVTAMSALSIFYPDANPSLMGLGVYKSKQVRDKQIVRVLGQAPTIAAAAYLRKAGKPPVQPLSNLSYSENFLYMVESMGDRSYKPNPRLARVLDILFILQAEHEMNCSTAAARHLSSSGGDVYTAVSGGVGAIYGPLHGGAVEATINMLSEIGTVENIPEFIESVKNKKRRLSGFGHRIYKNYDPRGKVVKKLADEVFSILGRDPLVEVGDALEKAALSDEYFVKRKLYPNVDFYSGLINRAMGIPSSFTAVSRIAGYLSHWRESLDDPDTKIMRPQQVYTGAGIRHYETVRERTKL", "length": 480 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LY06-1", "protein_name": "Glycine/proline-rich protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MITCILKISISSFIVLRIFSFLWFSRWFCCGLCGRFWFRCWFCCWFQFWFRCRFYCRFDTGFDVRFAAGFAADLTIGFTIGFDSGFATFLDVGLDDGFATGLDISFAGGFVTGFATDFDVGFDTGFTIGFDTGFDVGLPAVFSIGFDTGFAVGFAISFTVGFDAGFPTGFFVSLDVGFVADFVIGFATGIGVGFEVDFATDFDTCFATGFAVSFDVGFAGGFSIGFAADFANGFTVGFDGGFDASFFVGLDVGFVVGFVTSFAAGLDVGFAIDFATGFDTGFAFGLAFGFDVGFAAGFAVGFATGFTVVFDVGFASDFFVGLDVGFLTGFATDFDIGFVVDFDIGFATGFVVGFDDGSIVGLVVGLPASLDDGLAIDFVVGLDIGFVTGLFVGLVDGLTTDLDVGLVDGLDDGLDDGLDVDLVVVGFVVDGLAVDLDVGLGVGLTVGFVDGLDVGFDDGLDADTVDGLDVGLDDGLDVDLVDGLDIGLDDGLDVGLDDGLDFGLVDGLDVDLDDGLDVDLVDGLDIGLDDGLDVGLDDGLDFGLVDDGLVVGLFDVFVGTGLSWEIPPPGKLPPDASPLGIGSFGVGPPGASPFIASPSGEGPLSEGLLGIRSFGISPLSIRPLGISPLGISPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDPLGAGSLGISPLGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLLGAGPPGVGPVIASPPGEGPRDAGPLGAGSLGISPLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPPDVGPFGISPPIIDPPGESESDGDPAGKLPLDISPLSKGPSCVSPLGVGPVIASPPGEGPLDAGPLGAGSLGISPLNIRRLSISPFGISPSSIDSPVAGTSIGGPPDEGASDGGPPDVGPFGISPPIIDPPGEDASDGDPPGKFPLDISPLGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAGPLGAGSLGISPLNIRRLGISPFGISPPNIDLPVAGTSIGGPLDEGASDGGPPDVGPFGISPSIIDPPGEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAGPPGDGPVIASPPGESPLDAGPLGAGSLGISPFGISPPNIDWPVAGTSFGGPPGEGASNGGPLVVGPFDMPVVGASDGDALEKLPLDISLPGKGPSDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPPDTDSFGGDPLCASPLGIDPPIVDASDGDPFGAGSPDEDPSNENASGEGASGESPPCSDVSCKGPSSAGASIGCSLDNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAALVTLPSGKDPFDISPPIVALLDVSPLGKTSSDAYSSGISPGIFEKSFPLVKLQTIEYM", "length": 1504 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9M2S0-1", "protein_name": "Probable mannose-1-phosphate guanylyltransferase 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKALILVGGFGTRLRPLTLSLPKPLVDFANKPMILHQIEALKAIGVDEVVLAINYEPEQLLVMSKFSNDVEATLGIKITCSQETEPLGTAGPLALARDKLVDGSGQPFFVLNSDVISDYPLEEMIAFHNAHGGEASIMVTKVDEPSKYGVVVMEEATGRVERFVEKPKLFVGNKINAGIYLLNPSVLDRIELRPTSIEKEIFPQIAEAEKLYAMLLPGFWMDIGQPRDYITGLRLYLDSLRKKSPSKLATGPHILGNVLVDETAEIGEGCLIGPNVAIGPGCVVESGVRLSHCTVMRGVHVKRYACISSSIIGWHSTVGQWARVENMSILGKNVYVCDEIYCNGGVVLHNKEIKSDILKPDIVM", "length": 364 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NR96-1", "protein_name": "Toll-like receptor 9", "gene_name": "TLR9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE", "length": 1032 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QUG3-1", "protein_name": "Prion-like protein doppel", "gene_name": "Prnd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK", "length": 179 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SAC9-1", "protein_name": "AP-1 complex subunit mu-1", "gene_name": "AP1M1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGAASALFLLDIKGRVLVWRDYRGDVTAAQAERFFTKLIETEGDSQSNDPVAYDNGVTYMFVQHSNIYLMIASRQNCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDFGYPQFTEARILSEFIKTDAYRMEVTQRPPMAVTNSVSWRSEGLKFKKNEVFLDVIESVNILVNSNGQIVRSDVVGALKMRTYLSGMPECKLGLNDRILLEAQGRAIKGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGSFDLMTYRLSTQVKPLIWVEAHIERHSRSRVEMLVKARSQFKDRSYATSVEIELPVPTDAYNPDVRTSLGSAAYAPEKDALVWKIQYFYGNKEHTLKADFHLPSIAAEEATPERKAPIRVKFEIPKFIVSGIQVRYLKIIEKSGYQAHPWVRYITMAGEYELRLM", "length": 428 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SCN2-1", "protein_name": "Cytochrome P450 71B31", "gene_name": "CYP71B31", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSMFLGLLFLFPLFFILFKNLLPPRKKLPPGPTGLPLIGNLHQLGRLLHSSLHKLSLEHGPVMLVRWGVVPMAVFSSNEAAKEVLKTHDLETCNRPKLVANGLFTHGYKDIGFTQYGEEWREMKKFVGLELFSPKKHKSFRYIREEEGDLLVKKISNYAQTQTLVDLRKSLFSYTASIIFREAFGQNFRECDYINMDKLEELVQETETNVCSLAFTDFFPRGLGWLVDRISGQHSRMNIAFSKLTTFFEDVIDELLKTKQLDDHSDLVTAMLDVINRPRKFGSLKITYDHLIAMMSDVVLAGVNAGTVTMIWTMTELTRHPRVMKKLQEEIRATLGPNKERITEEDLEKVEYLNLVIKESFRLHPPAPLLLPRETMSDIEIQGYHIPKNAHVKINTYAIGRDPKRWTNPEEFNPERFLNTSINYKGQHYELLPFGAGRRNCPGMTLGITILELGLLNILYYFDWSLPSGMTIKDIDMEEDGALNIAKKVPLQLVPTLP", "length": 498 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SJ39-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 6", "gene_name": "CYP705A6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAILSVDFQNCFIFIVLCLFSLFCYSLFFKKPKHPRGCDLPPSPPSLPIIGHLHLLFSPLTHKSLQKLSSKYGHLLHLRIFNVPVILVSSASVAYEIFRAHDVNVSSRGVAAIDESLLFGSSGIITAPYGDYWKFMKKLIATKLLRPQSLESSRGIRGEELTRFYNSLLDKARMTESVEISTEAMKLVNNTLCRMSMGRSFSEENGEAEKIRGLVGESYALTKKMFLASLLRKPLKKLRISLFEKEIMGVSDRLDELLERILVEHEEKLHEEHQGTDMMDVLLAASGDENAEYNITRNHIKSFFVEIFIGATDTSVQTTQWTMAEILNHPNVLERLRKDIDSVVGKTRLIHETDLPNLPYLQAVVKEGLRLHPPGPLLVRTFQERCKIKGFYIPEKTTLVINAYAVMRDPDSWEDPDEFKPERFLRAPPMGGSLDKFIEFS", "length": 442 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SMT4-1", "protein_name": "Large ribosomal subunit protein eL13y", "gene_name": "RPL13C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKHNNVIPNGHFKKKWENYVKTSFNQPAMKTRRRIARQNKAVKIFPRPTAGPIRPVVHAQTLTYNMKVRAGKGFTLEELKAAGIPKKLAPTIGISVDHHRKNRSLEGFQTNVQRLKTYKAKLVIFPRCARTVKVGDSAQQELANATQVQVDHMPIVREMPTMELVKLTSDMKLFNAYDKIRLEGINKRHAGVRAKRAAEAEKEEKK", "length": 206 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SSB4-1", "protein_name": "26S proteasome regulatory subunit 7 homolog B", "gene_name": "RPT1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIIRDIMEDPENEGPHNMRSDFEPLLSVLRLRDYETGDIIEFDSTEASEEALSDITEFGSTEASEAHFEEPYSARIKKVEKEINELAEKICNLGIKESDTGLAPPNQWDLVSDKQMMQEEQPLLVATCTQIISPNTEDAKYVVDIKKIGKYVVGLGDKASPTDIEAGMRVGVDQKKYQIQIPLPPKIDPSVTMMTVEEKPDATYSDIGGCKEQIEKIREVVELPMLHPEKFVRLGIDPPKGVLCYGPPGSGKTLVARAVANRTGACFIRVVGSELVQKYIGEGARMVRELFQMARSKKACILFFDEIDAIGGARFDDGVGSDNEVQRTMLEILYQLDGFDARGNIKVLMATNRPDILDPALLRPGRLDRKVEFCLPDLEGRTQIFKIHTRTMSCERDIRFELLAGLCPNSTGADIRSVCIEAGMYAIGARRKSVTEKDFLDAVNKVVKGYQKFSATPKYMAYYI", "length": 464 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SVM4-1", "protein_name": "Serine hydroxymethyltransferase 5", "gene_name": "SHM5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEPVYSWGNTHLDFVDPEIYDLIEKEKHRQCRGIELIAAENFTSVAVMEALGSCLTNKYSEGMPGNRYYGGTEFIDEIESLCRSRSLEAFHCNPEKWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHITHGYYSSGGKNISATSIYFENLPYKVDSKTGYIDYDKLEEKAMDFRPKLIICGGTSYPREWDYARFRAVADKVGAFLLCDMAHNSALVAAQEAADPFEYCDVVTTSTHKSLRGPRAGMIFYRKGPKPAKKGQPEGEVYDFDAKINSAVFPALQSGPHNNKIGALAVALKQVMAPSFKVYAKQVKANAACLASYLINKGYTLVTDGTDNHLILWDLRPLGLTGNKVEKVCELCYITLNRNAVFGDTSFLAPGGVRIGTPAMTSRGLVEKDFEKIGEFLHRAVTITLDIQEQYGKVMKDFNKGLVNNKEIDEIKADVEEFTYDFDMPGFFISESRND", "length": 470 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SWH4-1", "protein_name": "Syntaxin-42", "gene_name": "SYP42", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATRNRTTVYRKHRDACKSARAPLSLSASDSFGGPVIEMVSGSFSRSNHSSYAPLNSYDPGPSSSDAFTIGMPPAWVDDSEEITFNIQKVRDKMNELAKAHSKALMPTFGDNKGIHREVEMLTHEITDLLRKSEKRLQMLSTRGPSEESNLRKNVQRSLATDLQNLSMELRRKQSTYLKRLQQQKEGQDEVDLEFNVNGKMSRLDEEDELGGMGFDEHQTIKLKEGQHVSAEREREIQQVLGSVNDLAQIMKDLSALVIDQGTIVDRIDYNVQNVSTSVEEGYKQLQKAERTQREGAMVKCATILLVLCLIMIVLLILKNILF", "length": 323 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SYN6-1", "protein_name": "SOUL heme-binding family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEAALSIFKLSFLLTLLSGGSDLIDSLPPNCNRAECPSYEVVHAGNGYEIHRYNTTVWISTEPIQDISLNEASGNGWNQLSDYMNGNNDYHQRIEIALPYITQVSQNLSTFIVSFFVPKAFQPDPPPGNNLHVQRWDSRYVAVKQISGYVADHKIGKQVAELKASLQGTVWAKAIEKSRETGGVGSAWAYTVAQFSWPFQWSQRVNEIWFPFEMEDEETVSIVTQ", "length": 225 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SZB4-1", "protein_name": "Putative DEAD-box ATP-dependent RNA helicase 43", "gene_name": "RH43", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEVDDGYVEYVPVEERLAQMKRKVVEEPGKGMMEHLSDKKKLMSVGELARGITYTEPLSTWWKPPLHVRKMSTKQMDLIRKQWHITVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEGPIALVICPSRELAKQTYDVVEQFVASLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQKTTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQSEITLLDLKHLLQEAKQRIPPVLAELNGPMEETETIANASGVKGCAYCGGLGHRILQCPKFEHQKSVAISSSRKDHFGSDGYRGEV", "length": 542 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9T0E0-1", "protein_name": "Putative ATPase, plasma membrane-like", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATGDSLEDIKIEIDDDLEKIPIEEVFKKLRCSREGLSGAEGKERLKIFGPNKLENKKKEHITLRFFALMFKPLSWVIQAAAIMAMLFANGDGRQLFLGIVCLLIVNTIICYLKEDDAANVVAMARAGLSPKTKVLRDGKWSEQEASILVPGDIVSIKPGDIIPCDARLLEGDTLKVDQSALTGEFGPITKGPGEEVFSGTTCKQGEMEAVVIATGVHTFSGTTAHLVDNRTNKVGHFRKVVTEIENLCVISIAIGISIEVIVMYWIQRRNFSDVINNLLVLVIGGIPLAMPTVLYVIMVTGSLRLYRTGTITQRITAIEDMAAIDVLCSDKTGTLTLNKLSVDKNLIKVYSKDVEKEQVLLLAARASRIENRDGIDAAMVGSLADPKEARAGIREVHFNLVDKRTALTYIDGNGDWHRVSKGTPEQILDLCNARDDLRKSVHSAIRNYAERGLKSFAISWFRNTNCNTVFFFPYQLCSEHKYHIVNKLQERHICGLIGDGVDDVPSLKKADVGIAVANATEAARAASDIVLTEPGLSVIIDAVLASRAILQQMKHYTIYAVSITIRVVFGFMFIALIWKFDFSPFMVLAIALLNEETTKAITMDNVTNPSPTPDSLKLKEIFATGVVYGSYMALITVVFFWAAYRTDIFPRTFHVRDLRGNEAEMMCALYLQVSIMSQALFFVIQSRSWFFVERPGELLFLSFVTVQTIATTLAVYASWETARIEGIGWSWAGVIWLYNIIFFFPLDIMKFGIRYILTGKAQSLFDNMVHLVLNSYAKLSNGIYNHTQADHTYSLLEVSTPPSQDLRGVGWV", "length": 813 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9T0H7-1", "protein_name": "Histone H2A.8", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVCNTNILKDVSTKISAFENVRMIMVEGEMFQVARIHKQLKNRVSAHSSVGATDVVYMTSILEYLTTEVLQLAENTSKDLKVKRITPRHLQLAIRGDEELDTLIKGTIIGGSVIPHIH", "length": 118 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VXF6-1", "protein_name": "Calnexin 14D", "gene_name": "Cnx14D", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAWKMLFAILLLLSAAKTGYLAPESENSVEDVQIEPGAIYGDEKFAYKSPVIDAEKFYFADHFDDVEASRKRWVLSQAKKNDIADEIAKYDGIWNWESPQRIFWANDLGLVLKSKAKHAAIAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGGSYLKLLSAGKGTEQLNRFNDKTPYTIMFGPDKCGNNLKMHFIFRHVNPLNGNITEKHCKKPNARLGVPFTDKLPHLYQLVVRPDNSFEIRLDHKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLPDTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKGKWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINAVGLELWSMSSDILFDNLIITDDVELARDFAANSFDIKRLYIDRESFGNKVVELARANRAIWGIVIVAIAVPVAITIFCKFGLGPSRVAAAKKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEKKEEEEEEEKEENKEEKKEEEKDDEKEMKDCEEEEDDEEKDDEEKTDERAAGDTNKESTPLSASPKKNQKSYLDNNEDEEDTLKNKEPTPKKRKRKALKE", "length": 639 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W240-1", "protein_name": "K Homology domain-containing protein", "gene_name": "cg3927", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "METPSELTEKQNQDQPTYQPRLNEVAQKFLADLDAERKRLSAEFPLCALLIDESVDRVYSTGRIPGKEPFADVYQQKPMKIIQKVFVPVNKFPKFNFTGKILGPKGNSLRRLQEETHCKIVIKGRNSMRDRNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRKYLIPDDNDDVWHEQQRELMEMNPKSAKKSNGLNMAPYRSNFDKAIGAIRNRAPKYNNQIRRVTENPREVAYMEEVEYDYDEHLMFCSPVVRL", "length": 270 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W4G6-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2861", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDYEIIEFVRRHISHIDISAETRMRYPDPISNNNFDWNSIGLGEQEDAIGQDQQSQALNENANNVSPDVPPSTIAEPTLEPSTIEGNQGQNPRIISSMPDMMPMANSFNPLININQEAGVVINTGINSIDNGLPSTYSEHISQPTNTESTRNMNSSIFDIPSDLDNNSSNESGDEVTQPTAKQSKINANFVCKIESDTNMDKLPTTSNNTNDKPPNNTDSDSDIISISDLIEDLNLDFNQLPITSCDVETHPADTQSNIDANLPYDLISAINMDFVNPANRTYMSAANSTRGTAYKIRKPRTVKRIIKAPSKSNIGKLLREAAKKENAAAGTQRPKKATSTITSSVQNFPNPNNWPACPFPMQNGTMPADEPNDLMPTVSQSLTVPAAQNRPIQTIGKIIKPPVKRTYTKRANKTNNTNIPNKNSTGVIQSNGVAPTIRQGLVEPGGTNILMPWNRQIPMVSVAENPRVQTIDKIIVPPPKRTYKKRVNKTVNTNQSSESAVGDGAPSAPIQSIPKVRKPRGPGKKTAKMVPGQESQQDIPLGVPPNGEAPQTSSQAPVPRVKRAYRKRANNTNNTNILNVNSTGVMESNGGGPTIPNSQQIPNVAVVLNLPIQPIKPKAPRKPRAKKVCNQQPGTDIPFGVSAQGQTAQIKPKPKPRAPRVPKEPKAPKEPKAPKVPKAPRVPKAPRVPKAPRVPKAPRVPKPPKEPKPPKEPKPPKQPKAPRVPKEPKPPKVPKEPKAPRAPRAPRVPKAPKEPKVPKIPKNPRVPKAPRQPKASMNKIQNTVKVPLPIEPVPLETPTYINPINTPVQSTVGEILALGSMPPISPIKFPVLFDEHAAQHTVANSNMPQSSLPTLDIPQLPTRNNKQPSTKSAEDTEILGLGKNKNAMKSDGRIKQGRVSKPSLRFSPSSSSLRPVVRSLSSSSSSSSSWSSCTTCSTCSSCSTCSSSSDSSQSSRSRNRKRRSPKVPIPHKLFESNGEINFQLGQPTRLESPSPPPPVPMQACGTFEEHLTDLTLVRVHAISPLRSPTYDFDFDLPEPMLSEESSSSSSESNDESNVNCQMAPNSQNVSMHFLKVMVFYNCYVLFQQLEKKHQSLFEESSSSSSSESNDETNVNCQMTPNSQNQKKLQSAPIREPSPDQPPEAASRSSNGGTIGPCNLKAFRRDFMISNAENTGFTNPSELNLKKCATKVCTPMERNSGSQLPIQNRFILPNSNKEEGKMNVEPVMPKHKPSRIPIRTKTPIALNLMKEPEDNARKPKNILKPFFSNADVNPCSSTDYEPNFKPCESPLPAKQNDFKLINKDKKSWVSHYQEQESQELKENSFFYAKFNLPNIPKKSFKDSKANAERRCTKTFEDVRKEAQQSRYTKAINKRQNKKAMLESALGNAITEDPTVNCNLADNPNDQVEMPRNPDIVEPTVKPVKFKAFVSASIKPKSSKKRKLMNSASNSKLFKFKIFESEVNKDENEEEDVIPDNLIIPVKRKQNISELLDMQPSTSKAAATITSQPKIAQLKRMPSKLLNEKMKSYAKKRSNDDENKDTKNTGMHMHRYKIPKLSANKPQNTSTTQSPTRGFSRLPGMYQEPNFQNAQHPFSTRGYYPYQRAYPLHRPTSQYHMNQPQPLRLHHSMYVDAEPSFESVFPAPRYQPYNINPSMRHHYSYPGEPSPSTYPMGGIPFQNNNTLYPPMRNDLCYPRGRLNYPVRNLPPMNSQGTYPPNYPQNFLPNYPPSRQFLLSMQRLADINKQIASGSIESVGGFIQMAYAGRKYRTLKDLRERTMLSKDSLRKIFKCMCKIKRPKWRISKFYLYAYWCEISGIPQSSEFGKPLELNAAYRKVISSYAENKFLRMESLMEKTGFGKSKLKRVLKMIGRKRSTKWRLLNYRKPLIHLHRSQDM", "length": 1893 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W6A5-1", "protein_name": "Green-sensitive opsin-1", "gene_name": "opn1mw1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNGTEGSNFYIPMSNRTGLVRSPYDYTQYYLAEPWKFKALAFYMFLLIIFGFPINVLTLVVTAQHKKLRQPLNYILVNLAFAGTIMVIFGFTVSFYCSLVGYMALGPLGCVMEGFFATLGGQVALWSLVVLAIERYIVVCKPMGSFKFSANHAMAGIAFTWFMACSCAVPPLFGWSRYLPEGMQTSCGPDYYTLNPEYNNESYVMYMFSCHFCIPVTTIFFTYGSLVCTVKAAAAQQQESESTQKAEREVTRMVILMVLGFLFAWVPYASFAAWIFFNRGAAFSAQAMAVPAFFSKTSAVFNPIIYVLLNKQFRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA", "length": 349 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9XK79-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "nad4L", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLIDLILIAIYVIGISGLIFNKNNIINILIISELNLGTLGMLFVLASVELNDILGELSGLYILTFTAAESAIGLAIVVILYSKTGIINIRHLNKLKG", "length": 98 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9Y2B0-1", "protein_name": "Protein canopy homolog 2", "gene_name": "CNPY2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGWGWLALLLGALLGTAWARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESSELDLQGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVKDKLCSKRTDLCDHALHISHDEL", "length": 182 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1X0-1", "protein_name": "C-C motif chemokine 27", "gene_name": "Ccl27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMEGLSPASSLPLLLLLLSPAPEAALPLPSSTSCCTQLYRQPLPSRLLRRIVHMELQEADGDCHLQAVVLHLARRSVCVHPQNRSLARWLERQGKRLQGTVPSLNLVLQKKMYSHPQQQN", "length": 120 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "S4R2L0-1", "protein_name": "Secretoglobin, family 2B, member 12", "gene_name": "Scgb2b12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGILLLLGLLITGELSFQTTEACVPFFEVYASVLSGSRVWLYHELQSFDATAEEKVALEKIQGCYREERLRNILLEPKIMEAMVASPECRSYYSLDNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "W4VSP8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFKNVLYFQAGLGVLANMVLLLFYIFIILGHRPKPTDLISCQLTFVHIIMVLTGGDILLTDLFELLNIENDLKCKTIFYISRVMRGLSICTTCLLSVFQAVTISPNTSLMAKFKQKLKKYMACVFLCIWSFNLAFSTNRIFYVGGFTNVSETNQMQVTKSCSLLPMNIIIRGFIFTISTSRDVFLVGVMLTTSVYMVITMFRYHRQCKYLYSISHLRESPEKRATQTIVLLVSFFVVMYWVDFIISFTSDMIWMYDPLILTVQKFMMYAYPTITPLVQISSDNRIIIMLKNLQSKHQQRFFNKDIFFSL", "length": 311 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "X1WF74-1", "protein_name": "Uncharacterized protein LOC100334758 precursor", "gene_name": "si:dkey-52p2.5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MARTSENMIGKVLFVLFLLSGPTSVLTDFHSLQILGTYIKGDTLFPQISFTFMLDDLTVGLYITERDEFIPRDNTTNEDETVSDMLDKIKNELQPLLKGTLIFQNSTESPQLFQIAWHCELLDNNKTGQMILKIAFSGSTTDEVSFYGNNFTCQCQNNMATVPLEYFQMQFKSIYYPVCMTTLGGYLVKRQVQVNRKVQPKVRLIKKVHPKSGGFRLSCLASEFYPYFINLTLLRDGQPVSDHEVTGGDLLPNGDGTYQMRKSLEIRADEREKHKYTCSAKHLDKNLDVDFEFDPSYPVKIVIPVVVLLSLVLVLTAVLIHKCMNKQAASPPEQQEPIEMGGRLRK", "length": 346 }, "evidence": [ { "id": "Q2YDJ5", "url": "https://omabrowser.org/oma/group/Q2YDJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ5", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDJ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDJ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDJ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 24 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 }, { "start_pos": 223, "end_pos": 225 }, { "start_pos": 24, "end_pos": 26 }, { "start_pos": 323, "end_pos": 325 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBE1-1", "uniprot_ac": "Q3ZBE1", "uniprot_id": "ARMC1_BOVIN", "mass": { "chemical_mass": 31280.0, "monoisotopic_mass": 31280.0 }, "refseq": { "ac": "NP_001015594", "name": "armadillo repeat-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015594" }, "gene_names": [ { "name": "ARMC1", "type": "recommended", "evidence": [ { "id": "Q3ZBE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ] }, { "name": "ARMC1", "type": "synonym", "evidence": [ { "id": "NP_001015594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015594" } ] } ], "protein_names": [ { "name": "Armadillo repeat-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1/entry#names_and_taxonomy" } ] }, { "name": "RasGEF domain family, member 1A", "type": "synonym", "evidence": [ { "id": "NP_001015594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015594" } ] }, { "name": "armadillo repeat-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015594" } ] } ], "function": [ { "annotation": "In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1#function" }, { "database": "UniProtKB", "id": "Q9NVT9", "url": "https://www.uniprot.org/uniprotkb/Q9NVT9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARMC1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1", "locus": { "chromosome": "14", "start_pos": 30000050, "end_pos": 30024834, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015901", "url": "https://www.ensembl.org/id/ENSBTAG00000015901" } ] } } ], "crossref": [ { "id": "Q3ZBE1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015901", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015901", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514000", "url": "https://www.ncbi.nlm.nih.gov/gene/514000", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514000", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514000", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VNEMNSC", "url": "https://omabrowser.org/oma/group/VNEMNSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBE1", "url": "https://www.orthodb.org/?gene=Q3ZBE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46840", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46840", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46840:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46840:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015594", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TVC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSSSSTMNEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKSTTPGETKLLASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282, "header": "sp|Q3ZBE1-1|ARMC1_BOVIN Isoform 1 of Armadillo repeat-containing protein 1 OS=Bos taurus OX=9913 GN=ARMC1 PE=2 SV=1 CANONICAL=Q3ZBE1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TVC9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1/entry#A0AAA9TVC9-1", "sequence": { "sequence": "MSARPYFIYGPSQPPCCPFSFARSSILGRVPCQPRKDERRAGNDVKLAKCYTESRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 180, "header": "tr|A0AAA9TVC9-1|A0AAA9TVC9_BOVIN Computationally mapped isoform of Armadillo repeat containing 1 OS=Bos taurus OX=9913 GN=ARMC1 PE=4 SV=1 CANONICAL=Q3ZBE1-1" }, "locus": { "chromosome": "14", "start_pos": 30019495, "end_pos": 30002044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104110.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104110.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101366.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101366.1" } ] } }, { "isoform_ac": "Q3ZBE1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1/entry#Q3ZBE1-1", "sequence": { "sequence": "MNSSSSTMNEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKSTTPGETKLLASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282, "header": "sp|Q3ZBE1-1|ARMC1_BOVIN Isoform 1 of Armadillo repeat-containing protein 1 OS=Bos taurus OX=9913 GN=ARMC1 PE=2 SV=1 CANONICAL=Q3ZBE1-1" }, "locus": { "chromosome": "14", "start_pos": 30019611, "end_pos": 30002044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021138.3", "url": "https://www.ensembl.org/id/ENSBTAT00000021138.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021138.2", "url": "https://www.ensembl.org/id/ENSBTAP00000021138.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 137, "end_pos": 137, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "site_lbl": "Thr137" }, { "start_pos": 189, "end_pos": 189, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "site_lbl": "Ser189" }, { "start_pos": 246, "end_pos": 246, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "site_lbl": "Ser246" }, { "start_pos": 260, "end_pos": 260, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "site_lbl": "Ser260" }, { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "site_lbl": "Ser267" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514000", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514000", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B0BN83-1", "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "Armc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSSSSTVNEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPSVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEIYDILQSSNMADGDSFNEINSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDAPVEVEENTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RTB0-1", "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "ARMC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNSSSSTMNEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q55CP4-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSALSMVQSLHKLAKDVDNREHIVKDQGCLAVLVMLLGSNEEDVEMVLLCLETLELLSHNQNNKQPMLKEPGLVSTLKKLQQKDQYKSIVDKVLINIEGSSDKGTINETTKIDTTTTTNTATATSYSTAPKKSASTSFSMLIGEKLPIKDTPVKSNNTASQVSSSKSIDPALIKTLLLHVKGMNNESTKKQLEECLLKTKGVISFMIDLSQCHATVRTSLSSDEIKLVIRNNVGLSASLIIDGQEEVESTPDYLPEPYNPNNSNSSKRWGWGSIISFGAQEQKQEGNWGWNSFSKVLFG", "length": 299 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZMQ0-1", "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "ARMC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNSTMSDEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFLDHPSPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEVYDILQSSNMSDMDNVNEMNYRRRKAQFFLGSTNKRAKTVVLHIDGLDDSSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALATAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTDLPEYLPEDESPSKEQDKAVSRVGSHPEGAASWLSTAANFLSRSFYW", "length": 279 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9D7A8-1", "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "Armc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSSSTMNEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEIYDILQSSNLADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDAPVEVEENTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVT9-1", "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "ARMC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSSTSTMSEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW", "length": 282 }, "evidence": [ { "id": "Q3ZBE1", "url": "https://omabrowser.org/oma/group/Q3ZBE1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular distribution of mitochondria", "id": "GO:0048312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048312", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBE1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 282, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBE1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBE1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 137, 189, 246, 260, 267 ], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0D6-1", "uniprot_ac": "Q3T0D6", "uniprot_id": "LEG4_BOVIN", "mass": { "chemical_mass": 37171.0, "monoisotopic_mass": 37171.0 }, "refseq": { "ac": "NP_001029940", "name": "galectin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940" }, "gene_names": [ { "name": "LGALS4", "type": "recommended", "evidence": [ { "id": "Q3T0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" } ] }, { "name": "LGALS4", "type": "synonym", "evidence": [ { "id": "NP_001029940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940" } ] } ], "protein_names": [ { "name": "Galectin-4", "type": "recommended", "evidence": [ { "id": "Q3T0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6/entry#names_and_taxonomy" } ] }, { "name": "Gal-4", "type": "synonym", "evidence": [ { "id": "Q3T0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6/entry#names_and_taxonomy" } ] }, { "name": "gal-4", "type": "synonym", "evidence": [ { "id": "NP_001029940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940" } ] }, { "name": "galectin-4", "type": "synonym", "evidence": [ { "id": "NP_001029940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940" } ] }, { "name": "lectin, galactoside-binding, soluble, 4 (galectin 4)", "type": "synonym", "evidence": [ { "id": "NP_001029940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940" } ] } ], "function": [ { "annotation": "Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D6", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6#function" }, { "database": "UniProtKB", "id": "G5E5J2", "url": "https://www.uniprot.org/uniprotkb/G5E5J2#function" }, { "database": "UniProtKB", "id": "ARBA00055823", "url": "https://www.uniprot.org/uniprotkb/ARBA00055823#function" }, { "database": "UniProtKB", "id": "A0AAA9TXM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXM2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0D6", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LGALS4", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6", "locus": { "chromosome": "18", "start_pos": 48537032, "end_pos": 48543978, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016312", "url": "https://www.ensembl.org/id/ENSBTAG00000016312" } ] } } ], "crossref": [ { "id": "Q3T0D6", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0D6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00070", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00070", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614804", "url": "https://www.ncbi.nlm.nih.gov/gene/614804", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614804", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614804", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SFVINFM", "url": "https://omabrowser.org/oma/group/SFVINFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G5E5J2", "url": "https://www.orthodb.org/?gene=G5E5J2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T0D6", "url": "https://www.orthodb.org/?gene=Q3T0D6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029940", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TXM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5J2", "url": "https://www.uniprot.org/uniprotkb/G5E5J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5J2-1", "url": "https://www.uniprot.org/uniprotkb/G5E5J2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0D6", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0D6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFVPAPGYQPTYNPTLPYHNPIPGGLRVGMSVYIQGVASEHMKRFFVNFEVGQGQGADVAFHFNPRFDGWDKVVLNSKQNGSWGQEERKMSMPFRKGAAFELVFMVMTEHFKVVVNGTPFHEFKHRIPLQMVTHLHVDGDLMLQSINFIGGQPPSNQMPMPAQAYPMPMSAQAYPSPGQYYQQQSRLPTMEGPPAFNPPVPFNGRLQGGLIVRRTIIIKGYIPPTAKSFVINFKVGSSGDVALHINPRMTEGAVVRNSFLNGSWGSEERKVSYNPFGPGQFFDLSVRCGADRFKVYANGKHLFDFSHRLSAFQRVDLVEIHGDVTLSYVQI", "length": 332, "header": "sp|Q3T0D6-1|LEG4_BOVIN Isoform 1 of Galectin-4 OS=Bos taurus OX=9913 GN=LGALS4 PE=2 SV=1 CANONICAL=Q3T0D6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TXM2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6/entry#A0AAA9TXM2-1", "sequence": { "sequence": "MGNCPLECGQGYSPPCPARFFVNFEVGQGQGADVAFHFNPRFDGWDKVVLNSKQNGSWGQEERKMSMPFRKGAAFELVFMVMTEHFKVRAVGAGPPRPAPPSLLFFLSSCLPACLPFFPYSFPPAVSFFFFPLSLSPPSSLFSFLFLLSCLLANSFSFNFFFILELFKYKFSHLFFLFPFLHRGDPSDMFRVYHLAPLCSCEIEICVSRFRRIQLFATPWTAARQAPLSLKFSRATRKAQTHAKGSTELWETLLSWARADSCQFQVVVNGTPFHEFKHRIPLQMVTHLHVDGDLMLQSINFIGGQPPSNQMPMPAQAYPMPMSAQAYPSPGQYYQQQSRLPTMEGPPAFNPPVPFNGRLQGGLIVRRTIIIKGYIPPTAKSFVINFKVGSSGDVALHINPRMTEGAVVRNSFLNGSWGSEERKVSYNPFGPGQFFDLSVRCGADRFKVYANGKHLFDFSHRLSAFQRVDLVEIHGDVTLSYVQI", "length": 484, "header": "tr|A0AAA9TXM2-1|A0AAA9TXM2_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LGALS4 PE=1 SV=1 CANONICAL=Q3T0D6-1" }, "locus": { "chromosome": "18", "start_pos": 48541793, "end_pos": 48537133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111776.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111776.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102226.1" } ] } }, { "isoform_ac": "G5E5J2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6/entry#G5E5J2-1", "sequence": { "sequence": "MAFVPAPGYQPTYNPTLPYHNPIPGGLRVGMSVYIQGVASEHMKRFFVNFEVGQGQGADVAFHFNPRFDGWDKVVLNSKQNGSWGQEERKMSMPFRKGAAFELVFMVMTEHFKVVVNGTPFHEFKHRIPLQMVTHLHVDGDLMLQSINFIGGQPPSNQVPWGPHPGQYYQQQSRLPMLGCCVFFPQPVPFNGRLQGGLIVRRTIIIKGYIPPTAKSFVINFKVGSSGDVALHINPRMTEGAVVRNSFLNGSWGSEERKVSYNPFGPGQFFDLSVRCGADRFKVYANGKHLFDFSHRLSAFQRVDLVEIHGDVTLSYVQI", "length": 319, "header": "tr|G5E5J2-1|G5E5J2_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LGALS4 PE=1 SV=2 CANONICAL=Q3T0D6-1" }, "locus": { "chromosome": "18", "start_pos": 48543918, "end_pos": 48537133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021701.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021701.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021701.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021701.6" } ] } }, { "isoform_ac": "Q3T0D6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6/entry#Q3T0D6-1", "sequence": { "sequence": "MAFVPAPGYQPTYNPTLPYHNPIPGGLRVGMSVYIQGVASEHMKRFFVNFEVGQGQGADVAFHFNPRFDGWDKVVLNSKQNGSWGQEERKMSMPFRKGAAFELVFMVMTEHFKVVVNGTPFHEFKHRIPLQMVTHLHVDGDLMLQSINFIGGQPPSNQMPMPAQAYPMPMSAQAYPSPGQYYQQQSRLPTMEGPPAFNPPVPFNGRLQGGLIVRRTIIIKGYIPPTAKSFVINFKVGSSGDVALHINPRMTEGAVVRNSFLNGSWGSEERKVSYNPFGPGQFFDLSVRCGADRFKVYANGKHLFDFSHRLSAFQRVDLVEIHGDVTLSYVQI", "length": 332, "header": "sp|Q3T0D6-1|LEG4_BOVIN Isoform 1 of Galectin-4 OS=Bos taurus OX=9913 GN=LGALS4 PE=2 SV=1 CANONICAL=Q3T0D6-1" }, "locus": { "chromosome": "18", "start_pos": 48543918, "end_pos": 48537133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089640.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089640.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091917.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091917.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D6", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" } ], "site_lbl": "Ser267" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614804", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614804", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LGZ8-1", "protein_name": "Galectin", "gene_name": "LGALS4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFVPAPGYQPTYNPTLPYYKPIPGGLRGMSVYIQGVANEHMKRFFVNFVVGQGPGADVAFHFNPRFDGWDKVVFNSQQDGKWGNEEKKRSMPFRKGAAFELVIMVLPEHYKVVVNGDPFYEFGHRIPVQLVTHLQVDGDLTLQSINFIGGQPAPSPGPMPNPGTQGPGKHNQQPCNLPCMEGAPTFNPPVPYKARLQGGLVARRTIVIKGYVPPSGKSLVINFKVGSSGDVLHINPRLTEGIVVRNSYLNGKWGAEERKSSFNPFAPGQYFDLSIRCGLDRFKVYANGQHLFDFSHRLSNFQGVDTLEIQGDVTLSYVQI", "length": 321 }, "evidence": [ { "id": "Q3T0D6", "url": "https://omabrowser.org/oma/group/Q3T0D6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P38552-1", "protein_name": "Galectin-4", "gene_name": "Lgals4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAYVPAPGYQPTYNPTLPYKRPIPGGLSVGMSIYIQGIAKDNMRRFHVNFAVGQDEGADIAFHFNPRFDGWDKVVFNTMQSGQWGKEEKKKSMPFQKGHHFELVFMVMSEHYKVVVNGTPFYEYGHRLPLQMVTHLQVDGDLELQSINFLGGQPAASQYPGTMTIPAYPSAGYNPPQMNSLPVMAGPPIFNPPVPYVGTLQGGLTARRTIIIKGYVLPTAKNLIINFKVGSTGDIAFHMNPRIGDCVVRNSYMNGSWGSEERKIPYNPFGAGQFFDLSIRCGTDRFKVFANGQHLFDFSHRFQAFQRVDMLEIKGDITLSYVQI", "length": 324 }, "evidence": [ { "id": "Q3T0D6", "url": "https://omabrowser.org/oma/group/Q3T0D6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P56470-1", "protein_name": "Galectin-4", "gene_name": "LGALS4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTLEIQGDVTLSYVQI", "length": 323 }, "evidence": [ { "id": "Q3T0D6", "url": "https://omabrowser.org/oma/group/Q3T0D6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K419-1", "protein_name": "Galectin-4", "gene_name": "Lgals4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAYVPAPGYQPTYNPTLPYKRPIPGGLSVGMSVYIQGMAKENMRRFHVNFAVGQDDGADVAFHFNPRFDGWDKVVFNTMQSGQWGKEEKKKSMPFQKGKHFELVFMVMPEHYKVVVNGNSFYEYGHRLPVQMVTHLQVDGDLELQSINFLGGQPAAAPYPGAMTIPAYPAGSPGYNPPQMNTLPVMTGPPVFNPRVPYVGALQGGLTVRRTIIIKGYVLPTARNFVINFKVGSSGDIALHLNPRIGDSVVRNSFMNGSWGAEERKVAYNPFGPGQFFDLSIRCGMDRFKVFANGQHLFDFSHRFQAFQMVDTLEINGDITLSYVQI", "length": 326 }, "evidence": [ { "id": "Q3T0D6", "url": "https://omabrowser.org/oma/group/Q3T0D6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q3T0D6", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0D6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 332, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0D6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0D6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" }, { "id": "PRU00639", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00639" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galectin 1", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 150, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D6" }, { "id": "PRU00639", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00639" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galectin 2", "eco_id": "ECO_0000255", "start_pos": 203, "end_pos": 332, "start_aa": "Phe", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 267 ], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E996-1", "uniprot_ac": "Q5E996", "uniprot_id": "NOP16_BOVIN", "mass": { "chemical_mass": 21139.0, "monoisotopic_mass": 21139.0 }, "refseq": { "ac": "NP_001014856", "name": "nucleolar protein 16", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" }, "gene_names": [ { "name": "NOP16", "type": "recommended", "evidence": [ { "id": "Q5E996", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ] }, { "name": "HSPC111", "type": "synonym", "evidence": [ { "id": "NP_001014856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" } ] }, { "name": "NOP16", "type": "synonym", "evidence": [ { "id": "NP_001014856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" } ] } ], "protein_names": [ { "name": "Nucleolar protein 16", "type": "recommended", "evidence": [ { "id": "Q5E996", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E996/entry#names_and_taxonomy" } ] }, { "name": "NOP16 nucleolar protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001014856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" } ] }, { "name": "nucleolar protein 16 homolog", "type": "synonym", "evidence": [ { "id": "NP_001014856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" } ] }, { "name": "nucleolar protein 16", "type": "synonym", "evidence": [ { "id": "NP_001014856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOP16", "url": "https://www.uniprot.org/uniprotkb/Q5E996", "locus": { "chromosome": "7", "start_pos": 37851239, "end_pos": 37856056, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010734", "url": "https://www.ensembl.org/id/ENSBTAG00000010734" } ] } } ], "crossref": [ { "id": "Q5E996", "url": "https://alphafold.ebi.ac.uk/entry/Q5E996", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506421", "url": "https://www.ncbi.nlm.nih.gov/gene/506421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506421", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506421", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IDYVKHM", "url": "https://omabrowser.org/oma/group/IDYVKHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E996", "url": "https://www.orthodb.org/?gene=Q5E996", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13243:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13243:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014856", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TZS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E996-1", "url": "https://www.uniprot.org/uniprotkb/Q5E996-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDQTKSVRQNLAEMGLAMDPNRAVPLLKRKVKAMEVDVEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGENYKAMARDEKNYYQDTPKQIRNKINVYKRFYPAEWQAFTDSLQKNKMEVE", "length": 178, "header": "sp|Q5E996-1|NOP16_BOVIN Isoform 1 of Nucleolar protein 16 OS=Bos taurus OX=9913 GN=NOP16 PE=2 SV=1 CANONICAL=Q5E996-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TZS8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E996/entry#A0AAA9TZS8-1", "sequence": { "sequence": "MVRRLGFRRQETSARTASEMTVPRPPSFFPRSSHIRHAWDQTKSVRQNLAEMGLAMDPNRAVPLLKRKVKAMEVDVEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGENYKAMARDEKNYYQDTPKQIRNKINVYKRFYPAEWQAFTDSLQKNKMEVE", "length": 174, "header": "tr|A0AAA9TZS8-1|A0AAA9TZS8_BOVIN Computationally mapped isoform of Nucleolar protein 16 OS=Bos taurus OX=9913 GN=NOP16 PE=3 SV=1 CANONICAL=Q5E996-1" }, "locus": { "chromosome": "7", "start_pos": 37855857, "end_pos": 37851536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103091.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103091.1" } ] } }, { "isoform_ac": "A0AAF6YVN9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E996/entry#A0AAF6YVN9-1", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDQTKSVRQNLAEMGLAMDPNRAVPLLKRKVKAMEVDVEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGENYKVSGSGLAGGTTWVRGYPGPFGV", "length": 153, "header": "tr|A0AAF6YVN9-1|A0AAF6YVN9_BOVIN Computationally mapped isoform of Nucleolar protein 16 OS=Bos taurus OX=9913 GN=NOP16 PE=3 SV=1 CANONICAL=Q5E996-1" }, "locus": { "chromosome": "7", "start_pos": 37855961, "end_pos": 37852377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014212.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014212.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014212.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014212.5" } ] } }, { "isoform_ac": "Q5E996-1", "url": "https://www.uniprot.org/uniprotkb/Q5E996/entry#Q5E996-1", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDQTKSVRQNLAEMGLAMDPNRAVPLLKRKVKAMEVDVEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGENYKAMARDEKNYYQDTPKQIRNKINVYKRFYPAEWQAFTDSLQKNKMEVE", "length": 178, "header": "sp|Q5E996-1|NOP16_BOVIN Isoform 1 of Nucleolar protein 16 OS=Bos taurus OX=9913 GN=NOP16 PE=2 SV=1 CANONICAL=Q5E996-1" }, "locus": { "chromosome": "7", "start_pos": 37855961, "end_pos": 37851536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082497.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "site_lbl": "Thr144" }, { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "site_lbl": "Thr8" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506421", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506421", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YNA0-1", "protein_name": "Nucleolar protein 16", "gene_name": "NOP16", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKAKGKNRRQKFAYGLNRKRLYRSARRKAAPRIECSHIRHAWDATKSVAQNLAEMGLAGDPNKAVPIAKRRLQRMETESDGQEQDKMLVRKPYVLSEMEFEASLPEKKSNTLSRDLIDYVRYMIQNHGENYKEMARDEKNYYQDTPKQIKRKISVYKNFYPEEYKDFVASLKQEKMDVQ", "length": 180 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S398-1", "protein_name": "Nucleolar protein 16", "gene_name": "NOP16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIQCSHIRHAWDQTKSVRQNLAEMGLAMDPNRAVPLIKRKVKAMEVDREERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRNKINVYKRFYPADWQAFVDSLEKNKMEVD", "length": 178 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H196-1", "protein_name": "Nucleolar protein 16", "gene_name": "Nop16", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDHTRSVRQNLAEMGLAVDPNKAVPLRKRKVKAMEVDMEERPKDLVRKPYVLNDLEAEASLPEKKGNTLSRDLIEYVHYMVANHGEDYKAMARDEKNYYQDTPKQIRNKINVYKRFYPSEWQTFMDSLQNKKMEVD", "length": 178 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1RP77-1", "protein_name": "Nucleolar protein 16", "gene_name": "Nop16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDHTKSVRQNLAEMGLAMDPNKAVPLRKRKVKAMEVDTEERPKDLVRKPYVVNDLEAEASLPEKKGNTLSRDLIDYVHYMVENHGEDYKAMARDEKNYYQDTPKQIRNKINVYKRFYPTEWQVFVASLQNKKMEVD", "length": 178 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DGI3-1", "protein_name": "Nucleolar protein 16", "gene_name": "nop16", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGKIKKSRKRNTFNYNKNKKKLKKKLRRKEKPHIECPQIRKAWDEHKTVKQNLQDMGLAPGTKGMLPIKPKKNTKVEPMETNVLKPYVIEEMEAEASVRGNDRTTCSTDMIEYVQHMVKEHNEDYKAMARDEKNYYQDTPKQIKRKVELYKRCHPEQYAAFIASLQSQKST", "length": 171 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CPT5-1", "protein_name": "Nucleolar protein 16", "gene_name": "Nop16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDHTKSVRQNLAEMGLAMDPNKAVPLRKKKVKAMEVDTEERPRDLVRKPYVVNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRNKINVYKRFYPTEWQAFIDSLQSKKMEVD", "length": 178 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V9U9-1", "protein_name": "Nucleolar protein 16", "gene_name": "BcDNA:RE07994", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKIRKNHARKRYRYNVNRKTMNKTRSSTGKIKDPRMKKMWMEDQRVGTNFSEMGLAKDVNKAIAIPSYKKDRLLAARVVNGFLEEELDEDERRVLGLKKPVVEEGPKRGHVVQELEQLASERADPEFRLPKGVVKELSYFLNKHKFNYKAMVADRKNFGQWTWRQFRLKIRRFMSIPEQFNVYLEQKKLPVGVKPDWEEYESDSEWK", "length": 207 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3C1-1", "protein_name": "Nucleolar protein 16", "gene_name": "NOP16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKAKGKTRRQKFGYSVNRKRLNRNARRKAAPRIECSHIRHAWDHAKSVRQNLAEMGLAVDPNRAVPLRKRKVKAMEVDIEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRSKINVYKRFYPAEWQDFLDSLQKRKMEVE", "length": 178 }, "evidence": [ { "id": "Q5E996", "url": "https://omabrowser.org/oma/group/Q5E996/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q5E996", "url": "https://www.uniprot.org/uniprotkb/Q5E996" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E996-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E996-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E996" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 8, 144 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBS9-1", "uniprot_ac": "Q3ZBS9", "uniprot_id": "NNAT_BOVIN", "mass": { "chemical_mass": 9246.0, "monoisotopic_mass": 9246.0 }, "refseq": { "ac": "NP_001188253", "name": "neuronatin isoform alpha", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188253" }, "gene_names": [ { "name": "NNAT", "type": "recommended", "evidence": [ { "id": "Q3ZBS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ] }, { "name": "NNAT", "type": "synonym", "evidence": [ { "id": "NP_001188253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188253" } ] } ], "protein_names": [ { "name": "Neuronatin", "type": "recommended", "evidence": [ { "id": "Q3ZBS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9/entry#names_and_taxonomy" } ] }, { "name": "neuronatin isoform alpha", "type": "synonym", "evidence": [ { "id": "NP_001188253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188253" } ] } ], "function": [ { "annotation": "May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NNAT", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9", "locus": { "chromosome": "13", "start_pos": 66467760, "end_pos": 66464849, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003212", "url": "https://www.ensembl.org/id/ENSBTAG00000003212" } ] } } ], "crossref": [ { "id": "Q3ZBS9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003212", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003212", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "353114", "url": "https://www.ncbi.nlm.nih.gov/gene/353114", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:353114", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353114", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IAENECI", "url": "https://omabrowser.org/oma/group/IAENECI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBS9", "url": "https://www.orthodb.org/?gene=Q3ZBS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15285", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15285", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15285:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15285:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27808", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27808", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001188253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS9-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRHVLGERRQRAPN", "length": 81, "header": "sp|Q3ZBS9-1|NNAT_BOVIN Isoform 1 of Neuronatin OS=Bos taurus OX=9913 GN=NNAT PE=3 SV=1 CANONICAL=Q3ZBS9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YKK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9/entry#A0AAF6YKK8-1", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSVQVLPAEAGIHGVENRTARAGRAPPAGPQLRPQPPPLGGRVTRCSCAIPPAWEPAPRRNGASPVPSRQRSTCQGQ", "length": 125, "header": "tr|A0AAF6YKK8-1|A0AAF6YKK8_BOVIN Computationally mapped isoform of Neuronatin OS=Bos taurus OX=9913 GN=NNAT PE=3 SV=2 CANONICAL=Q3ZBS9-1" }, "locus": { "chromosome": "13", "start_pos": 66466756, "end_pos": 66465243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004170.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004170.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004170.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004170.6" } ] } }, { "isoform_ac": "Q3ZBS9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9/entry#Q3ZBS9-1", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRHVLGERRQRAPN", "length": 81, "header": "sp|Q3ZBS9-1|NNAT_BOVIN Isoform 1 of Neuronatin OS=Bos taurus OX=9913 GN=NNAT PE=3 SV=1 CANONICAL=Q3ZBS9-1" }, "locus": {} }, { "isoform_ac": "Q3ZBS9-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9/entry#Q3ZBS9-2", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFRYSLQKLAYTVSRTGRHVLGERRQRAPN", "length": 54, "header": "sp|Q3ZBS9-2|NNAT_BOVIN Isoform 2 of Neuronatin OS=Bos taurus OX=9913 GN=NNAT PE=3 SV=1 CANONICAL=Q3ZBS9-1" }, "locus": { "chromosome": "13", "start_pos": 66466619, "end_pos": 66465243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004171.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004171.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004171.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004171.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Analysis of imprinted messenger RNA expression during bovine preimplantation development.", "journal": "Biol. Reprod.", "date": "2004", "authors": "Ruddock Nancy T, Wilson Katrina J, Cooney Melissa A, Korfiatis Natasha A, Tecirlioglu R Tayfur, French Andrew J", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ], "reference": [ { "type": "PubMed", "id": "14668210", "url": "https://glygen.org/publication/PubMed/14668210" } ] } ], "pathway": [ { "id": "bta:353114", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353114", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q0Q043-1", "protein_name": "Neuronatin", "gene_name": "NNAT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRHVLGERRQRAPN", "length": 81 }, "evidence": [ { "id": "Q3ZBS9", "url": "https://omabrowser.org/oma/group/Q3ZBS9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q16517-1", "protein_name": "Neuronatin", "gene_name": "NNAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRQVLGERRQRAPN", "length": 81 }, "evidence": [ { "id": "Q3ZBS9", "url": "https://omabrowser.org/oma/group/Q3ZBS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61979-1", "protein_name": "Neuronatin", "gene_name": "Nnat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAHTVSRTGRQVLGERRQRAPN", "length": 81 }, "evidence": [ { "id": "Q3ZBS9", "url": "https://omabrowser.org/oma/group/Q3ZBS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 81, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32KM6-1", "uniprot_ac": "Q32KM6", "uniprot_id": "MORN3_BOVIN", "mass": { "chemical_mass": 27829.0, "monoisotopic_mass": 27829.0 }, "refseq": { "ac": "NP_001035640", "name": "MORN repeat-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035640" }, "gene_names": [ { "name": "MORN3", "type": "recommended", "evidence": [ { "id": "Q32KM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KM6" } ] }, { "name": "MORN3", "type": "synonym", "evidence": [ { "id": "NP_001035640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035640" } ] } ], "protein_names": [ { "name": "MORN repeat-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q32KM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KM6/entry#names_and_taxonomy" } ] }, { "name": "MORN repeat-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001035640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035640" } ] } ], "function": [ { "annotation": "Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (By similarity). May play a role in the regulation of spermatogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6#function" }, { "database": "UniProtKB", "id": "Q6PF18", "url": "https://www.uniprot.org/uniprotkb/Q6PF18#function" }, { "database": "UniProtKB", "id": "Q8C5T4", "url": "https://www.uniprot.org/uniprotkb/Q8C5T4#function" }, { "database": "UniProtKB", "id": "A0AAF6YMI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI0#function" }, { "database": "UniProtKB", "id": "ARBA00045851", "url": "https://www.uniprot.org/uniprotkb/ARBA00045851#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MORN3", "url": "https://www.uniprot.org/uniprotkb/Q32KM6", "locus": { "chromosome": "17", "start_pos": 53605588, "end_pos": 53594582, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004458", "url": "https://www.ensembl.org/id/ENSBTAG00000004458" } ] } } ], "crossref": [ { "id": "Q32KM6", "url": "https://alphafold.ebi.ac.uk/entry/Q32KM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004458", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004458", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531482", "url": "https://www.ncbi.nlm.nih.gov/gene/531482", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR003409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531482", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531482", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHGRFFH", "url": "https://omabrowser.org/oma/group/GHGRFFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KM6", "url": "https://www.orthodb.org/?gene=Q32KM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46511", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46511", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46511:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46511:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF02493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035640", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YMI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KM6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPIFKCPQKSEPLWKEWDQKAQKNGLRHQVFAVNGDHYVGEWKDNVKHGKGTQVWKKNGAIYEGDWKSGKRDGYGTLSLPDQETGKYKRAYSGWWKGDKKCGYGIQFFGPKEYYEGDWCGNQRSGWGRMYYSNGDIYEGQWRNDKPEGEGMLRLKNGNRYEGNWQRGVKNGSGRFFHLDHGQLFEGFWVDDVAKCGTMIDFGRDEAPQPTQFPIPEVKILDPDGVLEEALAMFKKTKEEGD", "length": 241, "header": "sp|Q32KM6-1|MORN3_BOVIN Isoform 1 of MORN repeat-containing protein 3 OS=Bos taurus OX=9913 GN=MORN3 PE=1 SV=1 CANONICAL=Q32KM6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YMI0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM6/entry#A0AAF6YMI0-1", "sequence": { "sequence": "TAGSDRSWRLRAATPSLFARDSRSRLRPPGERRSSQHAYIQVPAKVGAPVEGVGPEGPEEWTEAPGVRCQWRPLRGRVEGQRETRLCGKPVVWTEPWTKSQDAGVLSLALLLRGCVTLGKGTQVWKKNGAIYEGDWKSGKRDGYGTLSLPDQETGKYKRAYSGWWKGDKKCGYGIQFFGPKEYYEGDWCGNQRSGWGRMYYSNGDIYEGQWRNDKPEGEGMLRLKNGNRYEGNWQRGVKNGSGRFFHLDHGQLFEGFWVDDVAKCGTMIDFGRDEAPQPTQFPIPEVKILDPDGVLEEALAMFKKTKEEGD", "length": 311, "header": "tr|A0AAF6YMI0-1|A0AAF6YMI0_BOVIN Computationally mapped isoform of MORN repeat-containing protein 3 OS=Bos taurus OX=9913 GN=MORN3 PE=4 SV=1 CANONICAL=Q32KM6-1" }, "locus": { "chromosome": "17", "start_pos": 53604785, "end_pos": 53594664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005841.4", "url": "https://www.ensembl.org/id/ENSBTAT00000005841.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005841.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005841.3" } ] } }, { "isoform_ac": "Q32KM6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM6/entry#Q32KM6-1", "sequence": { "sequence": "MPIFKCPQKSEPLWKEWDQKAQKNGLRHQVFAVNGDHYVGEWKDNVKHGKGTQVWKKNGAIYEGDWKSGKRDGYGTLSLPDQETGKYKRAYSGWWKGDKKCGYGIQFFGPKEYYEGDWCGNQRSGWGRMYYSNGDIYEGQWRNDKPEGEGMLRLKNGNRYEGNWQRGVKNGSGRFFHLDHGQLFEGFWVDDVAKCGTMIDFGRDEAPQPTQFPIPEVKILDPDGVLEEALAMFKKTKEEGD", "length": 241, "header": "sp|Q32KM6-1|MORN3_BOVIN Isoform 1 of MORN repeat-containing protein 3 OS=Bos taurus OX=9913 GN=MORN3 PE=1 SV=1 CANONICAL=Q32KM6-1" }, "locus": { "chromosome": "17", "start_pos": 53604785, "end_pos": 53597024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110661.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110661.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101266.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531482", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531482", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HPK9-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "Morn3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVNKCPKKSEPLWKDWDRKALKNGMRHQVFAVNGDHYVGEWKDNLKHGKGTQVWKKSGAIYEGDWKFGKRDGYGTFSRPDPETGKYRREYSGWWKGDKKSGYGIQFFGPKDYYEGEWCGNQRCGWGRMYYSNGQIYEGQWRNDKPEGEGMLRLKNGNRYEGSWERGMKNGHGRFFHLDHGQLFEGFWVDDVAKCGTMIDFGRDEAPEPTQFPIPKVEIEDPDGVLREAIAALMNSKKEED", "length": 241 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1ZB08-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "Dmel\\CG14490", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSRTSGYSSGVRSQRYPGGQYQGKWLGQQPHGFGVKQTSSGLVYEGHWQKGQRHGIGSLRRKELDGRMERIYVGQWRENKRSGEGKQFYPDGSVYFGQWLADQRSGEGILWQADGGIYVGEWLRDKMHEKGLLFTATGNRYVGQFEGGCKSGSGVFYHASNGQRIQHGFWSKDICRTSLLSLPQDKNNEFMSKALL", "length": 197 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1RNQ2-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "MORN3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPISKCPKKSDPLWKEWDQKSQKNGLRHQVYAVNGDHYVGEWKDNMKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQKTGKHRRVYSGWWRGDKKSGYGIQFFGPKAYYEGDWCGNQRSGWGRMYYSNGDIYEGQWCNDKPDGEGMLRLKNGNRYEGYWERGMKNGLGRFFHLDHGQLFEGFWVDSVAKCGTMIDFGRDEAPEPTKFPIPEVKILDPDGVLEEAMAMFKKTQEED", "length": 240 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R7B3-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "Morn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSWQLSHKFRPAAGTWRTFPEKQRNAVSMPVTKCPRKSEPLWKGWDQKAQKNGLRHQVFAVNGDHYVGEWKGNLKHGKGTQVWKQSGAMYEGDWKFGKRDGYGILSHPDPETGKLKRVYSGWWKGDKKSGYGIQFFGPKEYYEGEWCSNQRSGWGRMYYNNGDIYEGQWKNDKPDGEGMLRLKNGNRYEGSWERGMKNGHGRFFHLDHGQLFEGFWVDNVAKCGTMIDFGRDEAPEPTQFPIPKVEILDPDGVLKEALDKLKKPEEEED", "length": 269 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PF18-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "MORN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWKDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD", "length": 240 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C5T4-1", "protein_name": "MORN repeat-containing protein 3", "gene_name": "Morn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVTKCPRKVEPPWKGWDRKAQKNGLRHQVFAVNGDHYVGEWKGNLKHGKGTQVWKKSGAVYEGDWKFGKRDGYGSLSHPDPETGKLRRVYSGWWKGDKKSGYGIQFFGPKEYYEGEWCNNQRSGWGRMYYNNGDIYEGQWQNDKPEGEGMLRLKNGNRYEGIWERGMKNGHGRFFHLDHGQLFEGYWVDNVAKCGTMIDFGRDEAPEPTQFPIPKVEILDPDGVLKEALDKLMKPEEEEG", "length": 241 }, "evidence": [ { "id": "Q32KM6", "url": "https://omabrowser.org/oma/group/Q32KM6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of signal transduction by p53 class mediator", "id": "GO:1901797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901797", "evidence": [ { "database": "UniProtKB", "id": "Q32KM6", "url": "https://www.uniprot.org/uniprotkb/Q32KM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KM6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KM6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KM6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCA1-1", "uniprot_ac": "Q3ZCA1", "uniprot_id": "LRAT1_BOVIN", "mass": { "chemical_mass": 33127.0, "monoisotopic_mass": 33127.0 }, "refseq": { "ac": "NP_001029831", "name": "protein LRATD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" }, "gene_names": [ { "name": "LRATD1", "type": "recommended", "evidence": [ { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ] }, { "name": "FAM84A", "type": "synonym", "evidence": [ { "id": "NP_001029831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" }, { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ] }, { "name": "LRATD1", "type": "synonym", "evidence": [ { "id": "NP_001029831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" } ] } ], "protein_names": [ { "name": "Protein LRATD1", "type": "recommended", "evidence": [ { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1/entry#names_and_taxonomy" } ] }, { "name": "LRAT domain-containing 1", "type": "synonym", "evidence": [ { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM84A", "type": "synonym", "evidence": [ { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 84 member A", "type": "synonym", "evidence": [ { "id": "NP_001029831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" } ] }, { "name": "protein FAM84A", "type": "synonym", "evidence": [ { "id": "NP_001029831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" } ] }, { "name": "protein LRATD1", "type": "synonym", "evidence": [ { "id": "NP_001029831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831" } ] } ], "function": [ { "annotation": "May play a role in cell morphology and motility.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1#function" }, { "database": "UniProtKB", "id": "Q96KN4", "url": "https://www.uniprot.org/uniprotkb/Q96KN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRATD1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1", "locus": { "chromosome": "11", "start_pos": 83656670, "end_pos": 83676703, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004948", "url": "https://www.ensembl.org/id/ENSBTAG00000004948" } ] } } ], "crossref": [ { "id": "Q3ZCA1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004948", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004948", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539071", "url": "https://www.ncbi.nlm.nih.gov/gene/539071", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539071", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539071", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IYEHDDQ", "url": "https://omabrowser.org/oma/group/IYEHDDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCA1", "url": "https://www.orthodb.org/?gene=Q3ZCA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46341", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46341", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46341:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46341:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04970", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029831", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YMY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCA1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKAPPGCAPCPESPSRHHHHHHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLCQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLADNKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE", "length": 297, "header": "sp|Q3ZCA1-1|LRAT1_BOVIN Isoform 1 of Protein LRATD1 OS=Bos taurus OX=9913 GN=LRATD1 PE=2 SV=1 CANONICAL=Q3ZCA1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YMY4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1/entry#A0AAF6YMY4-1", "sequence": { "sequence": "MAFLALGPRQVLGVQWGFFTPRFSFTAWICSSGQSTIPGGWCARLRSVAAAAGRGGKRAAQIPAPGPRLAASLMGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKAPPGCAPCPESPSRHHHHHHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLCQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLADNKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE", "length": 370, "header": "tr|A0AAF6YMY4-1|A0AAF6YMY4_BOVIN Computationally mapped isoform of LRAT domain containing 1 OS=Bos taurus OX=9913 GN=LRATD1 PE=3 SV=1 CANONICAL=Q3ZCA1-1" }, "locus": { "chromosome": "11", "start_pos": 83676665, "end_pos": 83674099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006512.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006512.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006512.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006512.6" } ] } }, { "isoform_ac": "Q3ZCA1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1/entry#Q3ZCA1-1", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKAPPGCAPCPESPSRHHHHHHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLCQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLADNKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE", "length": 297, "header": "sp|Q3ZCA1-1|LRAT1_BOVIN Isoform 1 of Protein LRATD1 OS=Bos taurus OX=9913 GN=LRATD1 PE=2 SV=1 CANONICAL=Q3ZCA1-1" }, "locus": { "chromosome": "11", "start_pos": 83674989, "end_pos": 83674099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090010.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090010.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086282.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086282.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ], "site_lbl": "Ser38" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539071", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539071", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QK19-1", "protein_name": "LRAT domain containing 1", "gene_name": "LRATD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKGPPGCAPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE", "length": 292 }, "evidence": [ { "id": "Q3ZCA1", "url": "https://omabrowser.org/oma/group/Q3ZCA1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LDI9-1", "protein_name": "Protein LRATD1", "gene_name": "Lratd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKGPPGCSPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVTGGPQGADLSVYTVTALPAICEPGDLLELLWLQPATEQPAPAPHWAVYVGGGQIIHLYQGEIRQDSLYQAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLEENKVHTARFHSLEDLIREKRRIDASGRLRVLQELEDFVDDKE", "length": 292 }, "evidence": [ { "id": "Q3ZCA1", "url": "https://omabrowser.org/oma/group/Q3ZCA1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BWY1-1", "protein_name": "LRAT domain containing 1", "gene_name": "FAM84A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKYSVKGSGSPDQETPTHHLHHQLVLNETQFSAFRGQECIFSKVSSGPQAGDLSVYSVSALPALCKPGDLLELLYLGPSEQPPPHWAVYVGSGQIIHLHQGQIRQDSLYEAPAGNVGRVVNSWYRFRPLVAELVVQNACGHLGLKSDEICWTNSESFAAWCRFGKREFKAGGELQAAAGTQQQYYLKIHLAENKVHTVRFHSLEDLIREKRRIDASGKLRVIKDLAIVDGKE", "length": 282 }, "evidence": [ { "id": "Q3ZCA1", "url": "https://omabrowser.org/oma/group/Q3ZCA1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q96KN4-1", "protein_name": "Protein LRATD1", "gene_name": "LRATD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDDEEDLDERGQPDKFGVKAPPGCTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE", "length": 292 }, "evidence": [ { "id": "Q3ZCA1", "url": "https://omabrowser.org/oma/group/Q3ZCA1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D650-1", "protein_name": "Protein LRATD1", "gene_name": "Lratd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKGPPGCSPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVTGGPQGADLSVYAVTALPAICEPGDLLELLWLQPATEQPAPAPHWAVYVGGGQVIHLHQGEIRQDSLYQAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLEENKVHTARFHSLEDLIREKRRIDASGRLRVLQELEDFVDDKE", "length": 292 }, "evidence": [ { "id": "Q3ZCA1", "url": "https://omabrowser.org/oma/group/Q3ZCA1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ], "pmid": "" }, { "name": "cell motility", "id": "GO:0048870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048870", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCA1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCA1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCA1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCA1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCA1" }, { "id": "PRU01283", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01283" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRAT", "eco_id": "ECO_0000255", "start_pos": 138, "end_pos": 233, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 38 ], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBW5-1", "uniprot_ac": "Q2TBW5", "uniprot_id": "ZNHI2_BOVIN", "mass": { "chemical_mass": 42819.0, "monoisotopic_mass": 42819.0 }, "refseq": { "ac": "NP_001035650", "name": "zinc finger HIT domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035650" }, "gene_names": [ { "name": "ZNHIT2", "type": "recommended", "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" } ] }, { "name": "ZNHIT2", "type": "synonym", "evidence": [ { "id": "NP_001035650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035650" } ] } ], "protein_names": [ { "name": "Zinc finger HIT domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger HIT domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001035650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035650" } ] }, { "name": "zinc finger, HIT type 2", "type": "synonym", "evidence": [ { "id": "NP_001035650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035650" } ] } ], "function": [ { "annotation": "May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW5", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "database": "UniProtKB", "id": "Q9UHR6", "url": "https://www.uniprot.org/uniprotkb/Q9UHR6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBW5", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNHIT2", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5", "locus": { "chromosome": "29", "start_pos": 43306427, "end_pos": 43325247, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063864", "url": "https://www.ensembl.org/id/ENSBTAG00000063864" } ] } } ], "crossref": [ { "id": "Q2TBW5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005073", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005073", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23024", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23024", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539138", "url": "https://www.ncbi.nlm.nih.gov/gene/539138", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539138", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539138", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMPDYKP", "url": "https://omabrowser.org/oma/group/LMPDYKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBW5", "url": "https://www.orthodb.org/?gene=Q2TBW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15555:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15555:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04438", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04438", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YNF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBW5", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBW5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPAGPCGFCPTGEAQPARYTCPRCNVPYCSLRCYRAHGSCAEEFYRDQVLGELRGRSASPSRLATALRRLRQQRETEDEPGDAGLRPGPAPGGLSGLWERLAPAEKVAFERLLSRGEAGRLLPPWRPWWWGRGAGPRLLEELGDAPSGDAEELEPSPARMPPEPVRDEPAAVEQVLGDLPGACPPAVPTRIPALASLSRGRTSPLVRFQLPNVLFAYAHTLALYHGGDEALLSDFCATLLGVSGALGAQQVFASAEEALQAAAHVLEAGEHPPGPLGTRGAMREAARILLGEGPANQKSYTLAALGDLAQTLGRARKQAVAPEERDRLYRARKKCQFLLSWTNENEDALTPLALDCATAHRAHTVAAEDVAALTGELEQLWGGPLPPARRTLIEELPG", "length": 399, "header": "sp|Q2TBW5-1|ZNHI2_BOVIN Isoform 1 of Zinc finger HIT domain-containing protein 2 OS=Bos taurus OX=9913 GN=ZNHIT2 PE=2 SV=1 CANONICAL=Q2TBW5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YNF1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5/entry#A0AAF6YNF1-1", "sequence": { "sequence": "MEPAGPCGFCPTGEAQPARYTCPRCNVPYCSLRCYRAHGSCAEEFYRDQVLGELRGRSASPSRLATALRRLRQQRETEDEPGDAGLRPGPAPGGLSGLWERLAPAEKVAFERLLSRGEAGRLLPPWRPWWWGRGAGPRLLEELGDAPSGDAEELEPSPARMPPEPVRDEPAAVEQVLGDLPGACPPAVPTRIPALASLSRGRTSPLVRFQLPNVLFAYAHTLALYHGGDEALLSDFCATLLGVSGALGAQQVFASAEEALQAARILLGEGPANQKSYTLAALGDLAQTLGRARKQAVAPEERDRLYRARKKCQFLLSWTNENEDALTPLALDCATAHRAHTVAAEDVAALTGELEQLWGGPLPPARRTLIEELPG", "length": 375, "header": "tr|A0AAF6YNF1-1|A0AAF6YNF1_BOVIN Computationally mapped isoform of Zinc finger HIT-type containing 2 OS=Bos taurus OX=9913 GN=ZNHIT2 PE=4 SV=1 CANONICAL=Q2TBW5-1" }, "locus": { "chromosome": "29", "start_pos": 43324007, "end_pos": 43322811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006686.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006686.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006686.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006686.4" } ] } }, { "isoform_ac": "Q2TBW5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5/entry#Q2TBW5-1", "sequence": { "sequence": "MEPAGPCGFCPTGEAQPARYTCPRCNVPYCSLRCYRAHGSCAEEFYRDQVLGELRGRSASPSRLATALRRLRQQRETEDEPGDAGLRPGPAPGGLSGLWERLAPAEKVAFERLLSRGEAGRLLPPWRPWWWGRGAGPRLLEELGDAPSGDAEELEPSPARMPPEPVRDEPAAVEQVLGDLPGACPPAVPTRIPALASLSRGRTSPLVRFQLPNVLFAYAHTLALYHGGDEALLSDFCATLLGVSGALGAQQVFASAEEALQAAAHVLEAGEHPPGPLGTRGAMREAARILLGEGPANQKSYTLAALGDLAQTLGRARKQAVAPEERDRLYRARKKCQFLLSWTNENEDALTPLALDCATAHRAHTVAAEDVAALTGELEQLWGGPLPPARRTLIEELPG", "length": 399, "header": "sp|Q2TBW5-1|ZNHI2_BOVIN Isoform 1 of Zinc finger HIT domain-containing protein 2 OS=Bos taurus OX=9913 GN=ZNHIT2 PE=2 SV=1 CANONICAL=Q2TBW5-1" }, "locus": { "chromosome": "29", "start_pos": 43306427, "end_pos": 43305654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100058.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100058.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081884.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539138", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539138", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RQU8-1", "protein_name": "Zinc finger HIT-type containing 2", "gene_name": "ZNHIT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPAGPCGICPAGEAQPARYTCPRCNVPYCSLRCYRAHGTCAEDFYRDQVLGELRGRSASPSRLASALRRLRQQRETEDEPEDAGLRPGPAPGGLSGLWERLAPAEKAAFERLLSRGEAGRLLPPWRPWWWGRGAGPRLLEELGDAPGRDADELEPAPAGSPPEPVKDEPAAAGPTPGDAPGVCAPAVPTRIPTLASLSRGRASPLVRFQLPNVLFAYAHTLALYHGGDEALLSDFCATLLGVSGALGAQQVFTSAEEALQAAAHVLEAGEHPPGPLGTRGAMREAARILLGEGPANQKGYTLAALGDLAQTLGRARKQAVATEERDRLYRARKKCQFLLAWTNENEVALTPLALDCARAHRAHAVAAEEVAALTGELEQLWGGPLPPAPRTLIEELPG", "length": 399 }, "evidence": [ { "id": "Q2TBW5", "url": "https://omabrowser.org/oma/group/Q2TBW5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7FG21-1", "protein_name": "Zinc finger, HIT-type containing 2", "gene_name": "Znhit2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCRKEASPALHAHKSGNNQRSAGSGGTGTGQAAPVSMEPAGLCGFCPAGEAVPARYTCPRCNAPYCSLRCYRAHGACAEDFYRDQVLRELRGRNASPSRLAGALRRLREQREAEDEPEETGLRPGTRPGGLSGLWERLAPAEKAAFERLLSRGEAGRLLPPWRPWWWGRGTGPRFLEELDDDASRDLAEPELLPARTGLESVDDAAAAGEPLAEDSSVARPPAMPARIPALASLSRSPTSPLVRFQLPNVLFAYAHTLALYHGGDDDALLSDFCATLLDVSGALGTQQVFHSTEEALQAAAHVLEAGEHPPGPLGTRGAMQEVARILLGEGPINQKGYTLIALGHLAQTLGRARKQAALTPLALDCARAHRAHAVTVEEMATLTGELERLWGGPVPPAPRILIEELPG", "length": 408 }, "evidence": [ { "id": "Q2TBW5", "url": "https://omabrowser.org/oma/group/Q2TBW5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7KSA2-1", "protein_name": "HIT-type domain-containing protein", "gene_name": "Dmel\\CG31223", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSEADEKCHFCREVSFKYTCPKCNALYCSVGCYKSKEHLKCSEAFYKSCIQDELTQNTVTQESQEDMRKIYDILKRMRETDSGFNPQEFDTDGLENSLDSDGGEEGESEEDEAEENVTEGDILDEDLEEDIATRLKGVDINDADEVWSRLTTEEQDEFQKLITNGDIMKLMPDYKPWWIKPKNSKIVIIPTPEEAAKKESRVPEIFGSIAKFSDICKKTPSPCLHYNLWNILSAYACVARFFGGEQRTNASEAVAHLVNLSATLKYGTNFEDAEDAIVSVEMEAITTGNGPAGAAAVGSAAGGANFLVDNREQLQQDARQLMATKEHKLAALSDVLYLLQQTKAISRRKNTQEAEFQKLFALASGSVQLDRTKLAQLVRKIEFMLSYVAREEVL", "length": 394 }, "evidence": [ { "id": "Q2TBW5", "url": "https://omabrowser.org/oma/group/Q2TBW5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9FN06-1", "protein_name": "HIT-type Zinc finger family protein", "gene_name": "MGI19.3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMPEKTIISSESSNSSPLNPSSTRIICHVCNKQFSQYTCPRCNFRYCSLPCYKSHSVQCTESFMRDNVNDELKQVRSDDQTKRKMLEILKRFHEEEEEDDGGIDSITDDEGLSLPEEIIQKIMNGDEVSLDDLSLEERKGFQRALASGELSKMIQPWDPWWLLASARTINLGLGGTQLVQCVEDEEETTVVSEIPRGPDTPLISLSKLTSTNPSPLLPIHLIDIAYSYCFTLRIYNGEWQSDSLGAATMVLTVSSVLGHNGQPETIKEVLSFCLEQTCSSAYKNLGGGLKFGLNLVDDVICFLSLGSGAMVCLLGDLQRLILGAIKEVKSSSGRDLKKKLKLAERKVFYMMCWVNEQNSEVWEALEPSVRAEKNSVVELNDYRGFPEMKKKDQFRKGGGVVIEEIE", "length": 406 }, "evidence": [ { "id": "Q2TBW5", "url": "https://omabrowser.org/oma/group/Q2TBW5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW5", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBW5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 399, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBW5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBW5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 10, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 10, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 22, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 22, "end_pos": 22, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 25, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 25, "end_pos": 25, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 30, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 30, "end_pos": 30, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 34, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 34, "end_pos": 34, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 38, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 38, "end_pos": 38, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 41, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 41, "end_pos": 41, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5#function" }, { "id": "Q2TBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW5" }, { "id": "PRU00453", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00453" } ], "binding_site_uniprot": 7, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 7, "end_pos": 7, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DS4-1", "uniprot_ac": "Q58DS4", "uniprot_id": "TM171_BOVIN", "mass": { "chemical_mass": 34911.0, "monoisotopic_mass": 34911.0 }, "refseq": { "ac": "NP_001014951", "name": "transmembrane protein 171", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951" }, "gene_names": [ { "name": "TMEM171", "type": "recommended", "evidence": [ { "id": "Q58DS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS4" } ] }, { "name": "PRP2", "type": "synonym", "evidence": [ { "id": "NP_001014951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951" } ] }, { "name": "TMEM171", "type": "synonym", "evidence": [ { "id": "NP_001014951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951" } ] } ], "protein_names": [ { "name": "Transmembrane protein 171", "type": "recommended", "evidence": [ { "id": "Q58DS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS4/entry#names_and_taxonomy" } ] }, { "name": "proline-rich protein PRP2", "type": "synonym", "evidence": [ { "id": "NP_001014951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951" } ] }, { "name": "transmembrane protein 171", "type": "synonym", "evidence": [ { "id": "NP_001014951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DS4", "url": "https://www.uniprot.org/uniprotkb/Q58DS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM171", "url": "https://www.uniprot.org/uniprotkb/Q58DS4", "locus": { "chromosome": "20", "start_pos": 8497859, "end_pos": 8508386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008494", "url": "https://www.ensembl.org/id/ENSBTAG00000008494" } ] } } ], "crossref": [ { "id": "Q58DS4", "url": "https://alphafold.ebi.ac.uk/entry/Q58DS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008494", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008494", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538802", "url": "https://www.ncbi.nlm.nih.gov/gene/538802", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538802", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538802", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WHTIQLN", "url": "https://omabrowser.org/oma/group/WHTIQLN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DS4", "url": "https://www.orthodb.org/?gene=Q58DS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31617", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31617", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31617:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31617:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15471", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15471", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YS80", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YS80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YS80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YS80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DS4", "url": "https://www.uniprot.org/uniprotkb/Q58DS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DS4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPAAAAEPDGVRGDRHVSKLIFFLFVIGAILLCVGVLLSIFGFQACQYKTFPDCSMMLKIAGPACAVVGLGAVILARSRARLQQTEERLRGNNQADSDRPFLCGESRQFVQCLIFGFLFLTSGMLISVLGIWVPGCGSDWMQESLNETDTADSEPQICGFLSLQILGPLIVLVGLCFFVVAHVKKRSNLNGDQDASESEERQTQSLEPIQVTVGDAVIIFPPPPPPYFPESSASAAARSPGTDGLLPDESPPSYYSIFQSGSPTPEGQGAASERDCELIYTISGTASSSETSHTLHLLSELPPRYEEKETATTTSLSPSSEPSPP", "length": 326, "header": "sp|Q58DS4-1|TM171_BOVIN Isoform 1 of Transmembrane protein 171 OS=Bos taurus OX=9913 GN=TMEM171 PE=2 SV=1 CANONICAL=Q58DS4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YS80-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS4/entry#A0AAF6YS80-1", "sequence": { "sequence": "MALALGTQSLALSWDHGGKWHRICFKFSFFEAAKTIEGNPYIPPTSGKGPLLAMSPAAAAEPDGVRGDRHVSKLIFFLFVIGAILLCVGVLLSIFGFQACQYKTFPDCSMMLKIAGPACAVVGLGAVILARSRARLQQTEERLRGNNQADSDRPFLCGESRQFVQCLIFGFLFLTSGMLISVLGIWVPGCGSDWMQESLNETDTADSEPQICGFLSLQILGPLIVLVGLCFFVVAHVKKRSNLNGDQDASESEERQTQSLEPIQVTVGDAVIIFPPPPPPYFPESSASAAARSPGTDGLLPDESPPSYYSIFQSGSPTPEGQGAASERDCELIYTISGTASSSETSHTLHLLSELPPRYEEKETATTTSLSPSSEPSPP", "length": 379, "header": "tr|A0AAF6YS80-1|A0AAF6YS80_BOVIN Computationally mapped isoform of Transmembrane protein 171 OS=Bos taurus OX=9913 GN=TMEM171 PE=4 SV=1 CANONICAL=Q58DS4-1" }, "locus": { "chromosome": "20", "start_pos": 8506593, "end_pos": 8497944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011197.4", "url": "https://www.ensembl.org/id/ENSBTAT00000011197.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011197.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011197.3" } ] } }, { "isoform_ac": "Q58DS4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS4/entry#Q58DS4-1", "sequence": { "sequence": "MSPAAAAEPDGVRGDRHVSKLIFFLFVIGAILLCVGVLLSIFGFQACQYKTFPDCSMMLKIAGPACAVVGLGAVILARSRARLQQTEERLRGNNQADSDRPFLCGESRQFVQCLIFGFLFLTSGMLISVLGIWVPGCGSDWMQESLNETDTADSEPQICGFLSLQILGPLIVLVGLCFFVVAHVKKRSNLNGDQDASESEERQTQSLEPIQVTVGDAVIIFPPPPPPYFPESSASAAARSPGTDGLLPDESPPSYYSIFQSGSPTPEGQGAASERDCELIYTISGTASSSETSHTLHLLSELPPRYEEKETATTTSLSPSSEPSPP", "length": 326, "header": "sp|Q58DS4-1|TM171_BOVIN Isoform 1 of Transmembrane protein 171 OS=Bos taurus OX=9913 GN=TMEM171 PE=2 SV=1 CANONICAL=Q58DS4-1" }, "locus": { "chromosome": "20", "start_pos": 8505318, "end_pos": 8497944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036824.3", "url": "https://www.ensembl.org/id/ENSBTAT00000036824.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000036676.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 265, "start_aa": "Thr", "end_pos": 265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr265", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DS4", "url": "https://www.uniprot.org/uniprotkb/Q58DS4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538802", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538802", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0TB45-1", "protein_name": "Transmembrane protein 171", "gene_name": "TMEM171", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPVAAAESDGVHRDRHVSKLIFFLFVMGAILLCVGVLLSIFGFQACQYETLPDCSMVLKIAGPACAVVGLGAVILARSRARLQQSEGRLRGNQGDSDRAFLCGESRQFVQCLIFGFLFLTSGMLISVLGIWVPGCGSDWAQEPLNETDTADSESQICGFLSLQILGPLIVLVGLCFFVVAHVKKRNNLNGGQDASESEERQPQHMEPVQVTVGDAVIIFPPPPPPYFPETSAAAASQGPGADDLLPNESPPSYYSIFHYGTPPPEGQGVTSERDCDSIYTISGTAPTSETSHTPSLSSELPPRYEEKETAATTSLSPSSEPSPP", "length": 325 }, "evidence": [ { "id": "Q58DS4", "url": "https://omabrowser.org/oma/group/Q58DS4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4KL18-1", "protein_name": "Transmembrane protein 171", "gene_name": "Tmem171", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSVGTAEPDGDQRDRHVSKLIFFLFVFGAALLCVGVLLSIFGYQACQYKPLSHCSIVLKIAGPSCAVVGLGAVILARSRARLHLRERQRQGLQDPDQSFFCGESRQFAQCLIFGFLFLTSGMLISILGIWVPGCDSDWAQEPLNETNTGEGEPQICGFLSLQIMGPLVVLVGLCFFVVAHVKKKNNLSSSRDTSEVEGGHAHSTEPVHITVGDSVIIFPPPPPPYFPESSAAAPSPGANSLHQIENPPSYSSLFNYGTPTPENQGAASEREQELIYTISGQGSSSERSYTGHLPLDLPPRYEEKETAPATPLGAPSDASPP", "length": 322 }, "evidence": [ { "id": "Q58DS4", "url": "https://omabrowser.org/oma/group/Q58DS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6K0P5-1", "protein_name": "Transmembrane protein 171", "gene_name": "Tmem171", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSVGTAEPDGDQRDRQVSKLIFFLFVFGAVLLCVGVLISIFGYQACQYKPLSHCSMVLKIAGPSCAVMGLGTVILARSRARLQLRERQRQGHQDPDQSFFCGESRQFAQCLIFGFLFLTSGMLISILGIWVPGCGSDWAQEPLNETNSGEGEPQICSFLSLQIMGPLIVLVGLCFFVVAHVKKKSNLSSSRDTSEIEGGHTHSTEPVHITVGDSVIIFPPPPPPYFAESSAAAPSPGANSLHRIENPPSYSSLFNLSRTPTPENQGAASERDREVIYTISGPGSSSESSHTGHLPLDLPPRYEEKETAPATPLGAPSESSPP", "length": 323 }, "evidence": [ { "id": "Q58DS4", "url": "https://omabrowser.org/oma/group/Q58DS4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WVE6-1", "protein_name": "Transmembrane protein 171", "gene_name": "TMEM171", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPAAAAEPDGDQQDRHVSKLIFCFFVFGAVLLCVGVLLSIFGFQACQYKPLPDCPMVLKVAGPACAVVGLGAVILARSRAQLQLRAGLQRGQQMDPDRAFICGESRQFAQCLIFGFLFLTSGMLISVLGIWVPGCGSNWAQEPLNETDTGDSEPRMCGFLSLQIMGPLIVLVGLCFFVVAHVKKRNTLNAGQDASEREEGQIQIMEPVQVTVGDSVIIFPPPPPPYFPESSASAVAESPGTNSLLPNENPPSYYSIFNYGRTPTSEGAASERDCESIYTISGTNSSSEASHTPHLPSELPPRYEEKENAAATFLPLSSEPSPP", "length": 324 }, "evidence": [ { "id": "Q58DS4", "url": "https://omabrowser.org/oma/group/Q58DS4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58DS4", "url": "https://www.uniprot.org/uniprotkb/Q58DS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DS4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 265 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2NL23-1", "uniprot_ac": "Q2NL23", "uniprot_id": "CC107_BOVIN", "mass": { "chemical_mass": 28441.0, "monoisotopic_mass": 28441.0 }, "refseq": { "ac": "NP_001069149", "name": "coiled-coil domain-containing protein 107 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069149" }, "gene_names": [ { "name": "CCDC107", "type": "recommended", "evidence": [ { "id": "Q2NL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL23" } ] }, { "name": "CCDC107", "type": "synonym", "evidence": [ { "id": "NP_001069149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069149" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 107", "type": "recommended", "evidence": [ { "id": "Q2NL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL23/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 107 precursor", "type": "synonym", "evidence": [ { "id": "NP_001069149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069149" } ] }, { "name": "coiled-coil domain-containing protein 107", "type": "synonym", "evidence": [ { "id": "NP_001069149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069149" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL23", "url": "https://www.uniprot.org/uniprotkb/Q2NL23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC107", "url": "https://www.uniprot.org/uniprotkb/Q2NL23", "locus": { "chromosome": "8", "start_pos": 59838963, "end_pos": 59833726, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011413", "url": "https://www.ensembl.org/id/ENSBTAG00000011413" } ] } } ], "crossref": [ { "id": "Q2NL23", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514786", "url": "https://www.ncbi.nlm.nih.gov/gene/514786", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514786", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514786", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQAWEEP", "url": "https://omabrowser.org/oma/group/NQAWEEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL23", "url": "https://www.orthodb.org/?gene=Q2NL23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37345:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37345:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001069149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069149", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YWE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL23", "url": "https://www.uniprot.org/uniprotkb/Q2NL23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL23-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVVSLAGTLGLLLVSALPEVLGDRRSPDRRAHPGDAGQVGPAAAEPRRQSPPSKNQRERARSGALPLGALYTAAAVAFVLYKCLQQGKDEAAVLQEEADKKDSLQSEQHLAQLTQQLVQTEQHLNSLMAQLDPLFERVTTLAGAQQELLHMKLQTIHQLLQDSKPNKGVEVPEPEASIPFLEDFCIEEDEEEAGDNQAWEEPLNWNTGTRNLTPPREMQPTLRRRCRKSAAQGLSHSPHWKEGKTVDGLVKQSLFL", "length": 258, "header": "sp|Q2NL23-1|CC107_BOVIN Isoform 1 of Coiled-coil domain-containing protein 107 OS=Bos taurus OX=9913 GN=CCDC107 PE=2 SV=1 CANONICAL=Q2NL23-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YWE7-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL23/entry#A0AAF6YWE7-1", "sequence": { "sequence": "MASVVSLAGTLGLLLVSALPEVLGDRRSPDRRAHPGDAGQVGPAAAEPRRQSPPSKNQRERARSGALPLGALYTAAAVAFVLYKCLQQGKDEAAVLQEEADKKDSLQSEQHLAQLTQQLVQTEQHLNSLMAQLDPLFERVTTLAGAQQELLHMKLQTIHQLLQDSKPNKGVEVPEPGTGLGENFEEQFVPGERQWDRSHESPQRLRAAIVQMQNSKRSWLSRGEFTHCWSLCRGRGSRSWS", "length": 241, "header": "tr|A0AAF6YWE7-1|A0AAF6YWE7_BOVIN Computationally mapped isoform of Coiled-coil domain containing 107 OS=Bos taurus OX=9913 GN=CCDC107 PE=4 SV=1 CANONICAL=Q2NL23-1" }, "locus": { "chromosome": "8", "start_pos": 59838884, "end_pos": 59833774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015165.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015165.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015165.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015165.4" } ] } }, { "isoform_ac": "Q2NL23-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL23/entry#Q2NL23-1", "sequence": { "sequence": "MASVVSLAGTLGLLLVSALPEVLGDRRSPDRRAHPGDAGQVGPAAAEPRRQSPPSKNQRERARSGALPLGALYTAAAVAFVLYKCLQQGKDEAAVLQEEADKKDSLQSEQHLAQLTQQLVQTEQHLNSLMAQLDPLFERVTTLAGAQQELLHMKLQTIHQLLQDSKPNKGVEVPEPEASIPFLEDFCIEEDEEEAGDNQAWEEPLNWNTGTRNLTPPREMQPTLRRRCRKSAAQGLSHSPHWKEGKTVDGLVKQSLFL", "length": 258, "header": "sp|Q2NL23-1|CC107_BOVIN Isoform 1 of Coiled-coil domain-containing protein 107 OS=Bos taurus OX=9913 GN=CCDC107 PE=2 SV=1 CANONICAL=Q2NL23-1" }, "locus": { "chromosome": "8", "start_pos": 59836250, "end_pos": 59833774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089924.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089924.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514786", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514786", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ADG1-1", "protein_name": "Coiled-coil domain containing 107", "gene_name": "Ccdc107", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "KSSRAENEPRVVGAYKVALPASLGELTDDTPPHAARLAPEGSLLGGLTVTCGGSLRACARGTLCPWSGDFPLGERIRNKVPQRRSQVGPGATEPRRQPPPKDQRERARAGSLSLGALYTAAIVAFVLFKCLQGPDEAAVPREEKNKKKSSQSEQQLVQLTQQLAQTEEHLNNLMTQLDPLFERVTTLVGTQRELLNAKLKTIHHLLQDCKPGIGVEAPEPEAPIHFPEDLGKEDQEDAGNSQAWEEPINWSSETWNLAPSWEVEQGLRRRWHKTKGPAVNGGQALKV", "length": 287 }, "evidence": [ { "id": "Q2NL23", "url": "https://omabrowser.org/oma/group/Q2NL23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WV48-1", "protein_name": "Coiled-coil domain-containing protein 107", "gene_name": "CCDC107", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAVSLLGVVGLLLVSALSGVLGDRANPDLRAHPGNAAHPGSGATEPRRRPPLKDQRERTRAGSLPLGALYTAAVAAFVLYKCLQGKDETAVLHEEASKQQPLQSEQQLAQLTQQLAQTEQHLNNLMAQLDPLFERVTTLAGAQQELLNMKLWTIHELLQDSKPDKDMEASEPGEGSGGESAGGGDKVSETGTFLISPHTEASRPLPEDFCLKEDEEEIGDSQAWEEPTNWSTETWNLATSWEVGRGLRRRCSQAVAKGPSHSLGWEGGTTAEGRLKQSLFS", "length": 283 }, "evidence": [ { "id": "Q2NL23", "url": "https://omabrowser.org/oma/group/Q2NL23/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCC3-1", "protein_name": "Coiled-coil domain-containing protein 107", "gene_name": "Ccdc107", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGAGPVLSILGLLLVSAPFGVLGERPSADLGAHPERGSQVSPGTTEPRRQPPPKDQRERARAGSLSLGALYTAAVVAFVLFKCLQGPDEAAVLREEKNKKKSSQSEQQLVQLTQQLAQTEQHLNHLMTQLDPLFEQVTTLVGTQRELLDTKLKTIHHLLQDCQPGTGVEVPEPEASIPFTEDLGKEDQEAGNSQAWEEPITWSPETRNLAPSWEVEQGLRRRWHKTVTKGPAVNGEQPLKV", "length": 242 }, "evidence": [ { "id": "Q2NL23", "url": "https://omabrowser.org/oma/group/Q2NL23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2NL23", "url": "https://www.uniprot.org/uniprotkb/Q2NL23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL23-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL23-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL23" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZY7-1", "uniprot_ac": "Q3SZY7", "uniprot_id": "ZFAN6_BOVIN", "mass": { "chemical_mass": 22519.0, "monoisotopic_mass": 22519.0 }, "refseq": { "ac": "NP_001029632", "name": "AN1-type zinc finger protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" }, "gene_names": [ { "name": "ZFAND6", "type": "recommended", "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ] }, { "name": "ZA20D3", "type": "synonym", "evidence": [ { "id": "NP_001029632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ] }, { "name": "ZFAND6", "type": "synonym", "evidence": [ { "id": "NP_001029632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" } ] } ], "protein_names": [ { "name": "AN1-type zinc finger protein 6", "type": "recommended", "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7/entry#names_and_taxonomy" } ] }, { "name": "AN1-type zinc finger protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" } ] }, { "name": "Zinc finger A20 domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7/entry#names_and_taxonomy" } ] }, { "name": "zinc finger A20 domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" } ] }, { "name": "zinc finger, A20 domain containing 3", "type": "synonym", "evidence": [ { "id": "NP_001029632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFAND6", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7", "locus": { "chromosome": "21", "start_pos": 26098392, "end_pos": 26043924, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012321", "url": "https://www.ensembl.org/id/ENSBTAG00000012321" } ] } } ], "crossref": [ { "id": "Q3SZY7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514167", "url": "https://www.ncbi.nlm.nih.gov/gene/514167", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514167", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514167", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCAMHRY", "url": "https://omabrowser.org/oma/group/YCAMHRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZY7", "url": "https://www.orthodb.org/?gene=Q3SZY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10634", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10634", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10634:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10634:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01428", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01428", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029632", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YXB8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY39", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY39-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZY7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAPSVTSLSESLPVQCTDGSVPEAQSALDSTASSVQPSPVSNQSLLSESVASSQVDSTSVDKAIPETEDLQASVSETAQQASEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 208, "header": "sp|Q3SZY7-1|ZFAN6_BOVIN Isoform 1 of AN1-type zinc finger protein 6 OS=Bos taurus OX=9913 GN=ZFAND6 PE=2 SV=1 CANONICAL=Q3SZY7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YXB8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7/entry#A0AAF6YXB8-1", "sequence": { "sequence": "QRRAPANRGALPRSRVTGRTTKQKSLINSGRRGRRRRGRSYQGFGGLTCPHSPAATGGGRQRVRRREPPPAPSVTSLSESLPVQCTDGSVPEAQSALDSTASSVQPSPVSNQSLLSESVASSQVDSTSVDKAIPETEDLQASVSETAQQASEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 227, "header": "tr|A0AAF6YXB8-1|A0AAF6YXB8_BOVIN Computationally mapped isoform of Zinc finger AN1-type containing 6 OS=Bos taurus OX=9913 GN=ZFAND6 PE=4 SV=1 CANONICAL=Q3SZY7-1" }, "locus": { "chromosome": "21", "start_pos": 26098049, "end_pos": 26043926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016349.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016349.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016349.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016349.6" } ] } }, { "isoform_ac": "A0ABI0NY39-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7/entry#A0ABI0NY39-1", "sequence": { "sequence": "MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPVQCTDGSVPEAQSALDSTASSVQPSPVSNQSLLSESVASSQVDSTSVDKAIPETEDLQASVSETAQQASEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 196, "header": "tr|A0ABI0NY39-1|A0ABI0NY39_BOVIN Computationally mapped isoform of AN1-type zinc finger protein 6 OS=Bos taurus OX=9913 GN=ZFAND6 PE=4 SV=1 CANONICAL=Q3SZY7-1" }, "locus": { "chromosome": "21", "start_pos": 26098049, "end_pos": 26089373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149457.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149457.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106235.1" } ] } }, { "isoform_ac": "Q3SZY7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7/entry#Q3SZY7-1", "sequence": { "sequence": "MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAPSVTSLSESLPVQCTDGSVPEAQSALDSTASSVQPSPVSNQSLLSESVASSQVDSTSVDKAIPETEDLQASVSETAQQASEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 208, "header": "sp|Q3SZY7-1|ZFAN6_BOVIN Isoform 1 of AN1-type zinc finger protein 6 OS=Bos taurus OX=9913 GN=ZFAND6 PE=2 SV=1 CANONICAL=Q3SZY7-1" }, "locus": { "chromosome": "21", "start_pos": 26098049, "end_pos": 26089373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066020.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066020.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056063.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056063.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "site_lbl": "Ser49" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514167", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514167", "resource": "KEGG Pathway" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1USH9-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "ZFAND6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAPSVSSLSESLPVQCTDGSVPEAQSTLDSTSSSLQPSPVPNQSLLSESVASSQVDSTSVDKAIPETEDLQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 208 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z4W8-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "ZFAND6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLALILVEPRCVEEEKMAQETNRSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSNGRISPPATSVSSITESLPVQCTEGSAQETQSTLDSSSTQSMQPSPVSSQSLLTESVASSQPDSTAVDKTVPETEELQASVSENAEPTPEEQDKSLDKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGMHRYSDVHSCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 225 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IHH7-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "Zfand6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSSGRISPPAASVSSLSESLPVQCTDGSVAGAQSALESTSSSLQPGPVSNQSLLSESVAPSQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 223 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6DGF4-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "Zfand6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAASVSSLSESLPVQCADGSVPDAQSALDSTSSSMQPGPVSNQSLLSESVAPSQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 223 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6FIF0-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "ZFAND6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPATSVSSLSESLPVQCTDGSVPEAQSALDSTSSSMQPSPVSNQSLLSESVASSQLDSTSVDKAVPETEDVQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 208 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCH6-1", "protein_name": "AN1-type zinc finger protein 6", "gene_name": "Zfand6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAASVSSLSESLPVQCADGSVPDAQSALDSTSSSMQPGPVSNQSLLSESVAPSQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI", "length": 223 }, "evidence": [ { "id": "Q3SZY7", "url": "https://omabrowser.org/oma/group/Q3SZY7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" }, { "name": "polyubiquitin modification-dependent protein binding", "id": "GO:0031593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031593", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein targeting to peroxisome", "id": "GO:0006625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006625", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" }, { "name": "regulation of canonical NF-kappaB signal transduction", "id": "GO:0043122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043122", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY7", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZY7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00451", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00451" } ], "binding_site_uniprot": 14, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 14, "end_pos": 14, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 149, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 149, "end_pos": 149, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 152, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 152, "end_pos": 152, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 163, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 163, "end_pos": 163, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 165, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 165, "end_pos": 165, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 170, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 170, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 173, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 173, "end_pos": 173, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 179, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 179, "end_pos": 179, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00451", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00451" } ], "binding_site_uniprot": 18, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 18, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00449", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00449" } ], "binding_site_uniprot": 181, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 181, "end_pos": 181, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00451", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00451" } ], "binding_site_uniprot": 30, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 30, "end_pos": 30, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7#function" }, { "id": "Q3SZY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY7" }, { "id": "PRU00451", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00451" } ], "binding_site_uniprot": 33, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 33, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 49 ], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBJ9-1", "uniprot_ac": "Q3ZBJ9", "uniprot_id": "BEX5_BOVIN", "mass": { "chemical_mass": 13179.0, "monoisotopic_mass": 13179.0 }, "refseq": { "ac": "NP_001069203", "name": "protein BEX5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" }, "gene_names": [ { "name": "BEX5", "type": "recommended", "evidence": [ { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ] }, { "name": "BEX5", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" } ] }, { "name": "NGFRAP1L1", "type": "synonym", "evidence": [ { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ] } ], "protein_names": [ { "name": "Protein BEX5", "type": "recommended", "evidence": [ { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9/entry#names_and_taxonomy" } ] }, { "name": "BEX family member 5", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" } ] }, { "name": "Brain-expressed X-linked protein 5 homolog", "type": "synonym", "evidence": [ { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9/entry#names_and_taxonomy" } ] }, { "name": "NGFRAP1-like 1", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" } ] }, { "name": "NGFRAP1-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" }, { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9/entry#names_and_taxonomy" } ] }, { "name": "brain-expressed X-linked protein 5 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" } ] }, { "name": "protein BEX5", "type": "synonym", "evidence": [ { "id": "NP_001069203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BEX5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9", "locus": { "chromosome": "X", "start_pos": 50185920, "end_pos": 50182720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014670", "url": "https://www.ensembl.org/id/ENSBTAG00000014670" } ] } } ], "crossref": [ { "id": "Q3ZBJ9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014670", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014670", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516056", "url": "https://www.ncbi.nlm.nih.gov/gene/516056", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516056", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516056", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GNIRGEW", "url": "https://omabrowser.org/oma/group/GNIRGEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBJ9", "url": "https://www.orthodb.org/?gene=Q3ZBJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19430:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19430:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069203", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKDPKERREEEQAPVQNEEACPMGGGEGPKPRENVRGDWDPPAQDFREDMPNGLVNNIDIIDGDADDMERFMEEMRELRRKIRELQLRYSLRILIGDPPHHDHHDEFCLMP", "length": 112, "header": "sp|Q3ZBJ9-1|BEX5_BOVIN Isoform 1 of Protein BEX5 OS=Bos taurus OX=9913 GN=BEX5 PE=3 SV=1 CANONICAL=Q3ZBJ9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0G6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9/entry#A0AAF6Z0G6-1", "sequence": { "sequence": "MEDLVGGIQEAPRVEEWVFRSVGAADFKAERGRLLLIPAGRRSGKKNLKMEKDPKERREEEQAPVQNEEACPMGGGEGPKPRENVRGDWDPPAQDFREDMPNGLVNNIDIIDGDADDMERFMEEMRELRRKIRELQLRYSLRILIGDPPHHDHHDEFCLMP", "length": 161, "header": "tr|A0AAF6Z0G6-1|A0AAF6Z0G6_BOVIN Computationally mapped isoform of Brain expressed X-linked 5 OS=Bos taurus OX=9913 GN=BEX5 PE=3 SV=1 CANONICAL=Q3ZBJ9-1" }, "locus": { "chromosome": "X", "start_pos": 50185042, "end_pos": 50183055, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019530.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019530.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019530.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019530.3" } ] } }, { "isoform_ac": "Q3ZBJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9/entry#Q3ZBJ9-1", "sequence": { "sequence": "MEKDPKERREEEQAPVQNEEACPMGGGEGPKPRENVRGDWDPPAQDFREDMPNGLVNNIDIIDGDADDMERFMEEMRELRRKIRELQLRYSLRILIGDPPHHDHHDEFCLMP", "length": 112, "header": "sp|Q3ZBJ9-1|BEX5_BOVIN Isoform 1 of Protein BEX5 OS=Bos taurus OX=9913 GN=BEX5 PE=3 SV=1 CANONICAL=Q3ZBJ9-1" }, "locus": { "chromosome": "X", "start_pos": 50185042, "end_pos": 50184707, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111142.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111142.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085713.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516056", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516056", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RYG4-1", "protein_name": "Brain expressed X-linked 5", "gene_name": "BEX5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENFPKENKGKEQAQMRNEEAHPFGGGEGQRPGENVPGDWVPPAQDFREDLPNRLVNNIDMIDGDADDMERFMEEMRELRRKIRELQLRYSLRILIGDLPHHDHHDEFCLMP", "length": 112 }, "evidence": [ { "id": "Q3ZBJ9", "url": "https://omabrowser.org/oma/group/Q3ZBJ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5H9J7-1", "protein_name": "Protein BEX5", "gene_name": "BEX5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENVPKENKVVEKAPVQNEAPALGGGEYQEPGGNVKGVWAPPAPGFGEDVPNRLVDNIDMIDGDGDDMERFMEEMRELRRKIRELQLRYSLRILIGDPPHHDHHDEFCLMP", "length": 111 }, "evidence": [ { "id": "Q3ZBJ9", "url": "https://omabrowser.org/oma/group/Q3ZBJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 112, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBJ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9#function" }, { "id": "Q3ZBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ9" } ], "binding_site_uniprot": 109, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared with FEM1B", "eco_id": "ECO_0000250", "start_pos": 109, "end_pos": 109, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T138-1", "uniprot_ac": "Q3T138", "uniprot_id": "BOLA1_BOVIN", "mass": { "chemical_mass": 14355.0, "monoisotopic_mass": 14355.0 }, "refseq": { "ac": "NP_001029524", "name": "bolA-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524" }, "gene_names": [ { "name": "BOLA1", "type": "recommended", "evidence": [ { "id": "Q3T138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T138" } ] }, { "name": "BOLA1", "type": "synonym", "evidence": [ { "id": "NP_001029524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524" } ] } ], "protein_names": [ { "name": "BolA-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3T138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T138/entry#names_and_taxonomy" } ] }, { "name": "bolA homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001029524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524" } ] }, { "name": "bolA-like 1", "type": "synonym", "evidence": [ { "id": "NP_001029524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524" } ] }, { "name": "bolA-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524" } ] } ], "function": [ { "annotation": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGE1#function" }, { "database": "UniProtKB", "id": "ARBA00053549", "url": "https://www.uniprot.org/uniprotkb/ARBA00053549#function" }, { "database": "UniProtKB", "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138#function" }, { "database": "UniProtKB", "id": "Q9Y3E2", "url": "https://www.uniprot.org/uniprotkb/Q9Y3E2#function" }, { "database": "UniProtKB", "id": "Q3E793", "url": "https://www.uniprot.org/uniprotkb/Q3E793#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOLA1", "url": "https://www.uniprot.org/uniprotkb/Q3T138", "locus": { "chromosome": "3", "start_pos": 20712339, "end_pos": 20724343, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006050", "url": "https://www.ensembl.org/id/ENSBTAG00000006050" } ] } } ], "crossref": [ { "id": "Q3T138", "url": "https://alphafold.ebi.ac.uk/entry/Q3T138", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006050", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006050", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509530", "url": "https://www.ncbi.nlm.nih.gov/gene/509530", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509530", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509530", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLGGFGK", "url": "https://omabrowser.org/oma/group/CLGGFGK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T138", "url": "https://www.orthodb.org/?gene=Q3T138", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46229:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46229:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01722", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01722", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T138-1", "url": "https://www.uniprot.org/uniprotkb/Q3T138-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSGQLVVRLFSMASRVCMSRGSAGSGVIGPVEAAIRTKLEQALNPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALSEELAGPVHALAIQARTPAQWKENPQLDTSPACLGGSKKSRN", "length": 135, "header": "sp|Q3T138-1|BOLA1_BOVIN Isoform 1 of BolA-like protein 1 OS=Bos taurus OX=9913 GN=BOLA1 PE=2 SV=1 CANONICAL=Q3T138-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGE1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T138/entry#A0AAF6ZGE1-1", "sequence": { "sequence": "MARPMLSGQLVVRLFSMASRVCMSRGSAGSGVIGPVEAAIRTKLEQALNPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALSEELAGPVHALAIQARTPAQWKENPQLDTSPACLGGSKKSRN", "length": 139, "header": "tr|A0AAF6ZGE1-1|A0AAF6ZGE1_BOVIN Computationally mapped isoform of BolA-like protein 1 OS=Bos taurus OX=9913 GN=BOLA1 PE=3 SV=1 CANONICAL=Q3T138-1" }, "locus": { "chromosome": "3", "start_pos": 20724144, "end_pos": 20713716, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007946.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007946.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043360.2" } ] } }, { "isoform_ac": "Q3T138-1", "url": "https://www.uniprot.org/uniprotkb/Q3T138/entry#Q3T138-1", "sequence": { "sequence": "MLSGQLVVRLFSMASRVCMSRGSAGSGVIGPVEAAIRTKLEQALNPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALSEELAGPVHALAIQARTPAQWKENPQLDTSPACLGGSKKSRN", "length": 135, "header": "sp|Q3T138-1|BOLA1_BOVIN Isoform 1 of BolA-like protein 1 OS=Bos taurus OX=9913 GN=BOLA1 PE=2 SV=1 CANONICAL=Q3T138-1" }, "locus": { "chromosome": "3", "start_pos": 20714120, "end_pos": 20713716, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096294.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096294.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080372.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080372.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 81, "end_pos": 81, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138" } ], "site_lbl": "Ser81" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509530", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509530", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AE96-1", "protein_name": "BolA family member 1", "gene_name": "LOC107049580", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPPPTLSALPSGPVARSILSKLTAALQPTHLHLEDHSPRHGAPPGSETHFGLLVVSGRFEGLSPIERHRLVHAVLGAELRGPLHALSIVARTPQQWERDPNIPQPPPCMGGSKRDKRQAEGDAAASQ", "length": 127 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SDF8-1", "protein_name": "BolA family member 1", "gene_name": "BOLA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSGQLVGRLFSMAGRVCLSRSSTGAGTIGPVEAAIRMKLEQALNPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHTALSEELAGPVHALAIQARTPAQWRENPQLDTSPPCLGGSKKTRGTP", "length": 137 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q06C60-1", "protein_name": "BolA-like protein 1", "gene_name": "Bola1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSARLARCMVSMATRACVSRGSAGSAAGGPVEAAIRAKLEQALSPEVLELRNESGGHAVPAGSETHFRVAVVSSRFEGMSPLQRHRLVHEALSEELAGPVHALAIQAKTPAQWRENPQLDISPPCLGGSKKTRGTS", "length": 137 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54G84-1", "protein_name": "BolA family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIRNLINGQLFKTSIETVKVRYFVVNNNNNNNNNNGGGEPIKNTIIEKLSNQFKPIHLDVVNESYMHSVPRGSETHFKVIIVSDIFNGKSVVAQHRLINDTLKNEMKNGVHALSIHCSTPDKWDESTISPSPGCMGGSKKEKQQKQQKDEK", "length": 151 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9D8S9-1", "protein_name": "BolA-like protein 1", "gene_name": "Bola1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSARSAQCMVSMATRSCVSRGSAGSAAAGPVEAAIRAKLEQALSPEVLELRNESGGHAVPAGSETHFRVAVVSSRFEGMSPLQRHRLVHEALSEELAGPVHALAIQAKTPAQWRENPQLDISPPCLGGSKKTRGTS", "length": 137 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VC53-1", "protein_name": "BolA-like protein DDB_G0274169", "gene_name": "CG13621", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLNFTLRRLTGVSIRNLNQLTPTISSLGQILPRATMSQEAGQYPPIESAMRKALNTELKPVYLEVINESPQHNVPKRSESHFRVFVVSEKFNDLTLIKRHRLVNDTVKNALKEAGFEFMHALSIEAKTPKQWEPEQEPEKSPPCLGGHGK", "length": 150 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3E2-1", "protein_name": "BolA-like protein 1", "gene_name": "BOLA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSGRLVLGLVSMAGRVCLCQGSAGSGAIGPVEAAIRTKLEEALSPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQARTPAQWRENSQLDTSPPCLGGNKKTLGTP", "length": 137 }, "evidence": [ { "id": "Q3T138", "url": "https://omabrowser.org/oma/group/Q3T138/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138" } ], "pmid": "" }, { "name": "iron-sulfur cluster assembly complex", "id": "GO:1990229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990229", "evidence": [ { "database": "UniProtKB", "id": "Q3T138", "url": "https://www.uniprot.org/uniprotkb/Q3T138" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T138-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 135, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T138-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T138" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 81 ], "sequon_annotation_sites": [ { "start_pos": 53, "end_pos": 55 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KU6-1", "uniprot_ac": "Q32KU6", "uniprot_id": "TSN6_BOVIN", "mass": { "chemical_mass": 27524.0, "monoisotopic_mass": 27524.0 }, "refseq": { "ac": "NP_001033198", "name": "tetraspanin-6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033198" }, "gene_names": [ { "name": "TSPAN6", "type": "recommended", "evidence": [ { "id": "Q32KU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ] }, { "name": "TSPAN6", "type": "synonym", "evidence": [ { "id": "NP_001033198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033198" } ] } ], "protein_names": [ { "name": "Tetraspanin-6", "type": "recommended", "evidence": [ { "id": "Q32KU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU6/entry#names_and_taxonomy" } ] }, { "name": "Tspan-6", "type": "synonym", "evidence": [ { "id": "Q32KU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU6/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-6", "type": "synonym", "evidence": [ { "id": "NP_001033198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033198" } ] }, { "name": "tspan-6", "type": "synonym", "evidence": [ { "id": "NP_001033198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033198" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6", "locus": { "chromosome": "X", "start_pos": 49636433, "end_pos": 49644611, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045550", "url": "https://www.ensembl.org/id/ENSBTAG00000045550" } ] } } ], "crossref": [ { "id": "Q32KU6", "url": "https://alphafold.ebi.ac.uk/entry/Q32KU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045550", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045550", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03161", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03161", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514741", "url": "https://www.ncbi.nlm.nih.gov/gene/514741", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514741", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514741", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YRNWEDT", "url": "https://omabrowser.org/oma/group/YRNWEDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KU6", "url": "https://www.orthodb.org/?gene=Q32KU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033198", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZY71", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZY71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZY71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZY71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KU6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIGTGTVIILLGTFGCFATCRASAWMLKLYAMFLTLIFLVELVAAIIGFVFRHEIKNSLKNNYEKALKQYNATGDYRSDAVDKIQSMLHCCGVTNYRDWKDTNYYSEKGFPESCCKLEDCSPQRDADKVNNEGCFIMVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV", "length": 245, "header": "sp|Q32KU6-1|TSN6_BOVIN Isoform 1 of Tetraspanin-6 OS=Bos taurus OX=9913 GN=TSPAN6 PE=2 SV=1 CANONICAL=Q32KU6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZY71-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU6/entry#A0AAF6ZY71-1", "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIGTGTVIILLGTFGCFATCRASAWMLKLYAMFLTLIFLVELVAAIIGFVFRHEIKNSLKNNYEKALKQYNATGDYRSDAVDKIQSMLHCCGVTNYRDWKDTNYYSEKGFPESCCKLEDCSPQRDADKVNNELIGIFLAYCLSRAITNNQYEIV", "length": 217, "header": "tr|A0AAF6ZY71-1|A0AAF6ZY71_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN6 PE=3 SV=1 CANONICAL=Q32KU6-1" }, "locus": { "chromosome": "X", "start_pos": 49641060, "end_pos": 49637373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086776.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086776.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060038.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060038.2" } ] } }, { "isoform_ac": "Q32KU6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU6/entry#Q32KU6-1", "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIGTGTVIILLGTFGCFATCRASAWMLKLYAMFLTLIFLVELVAAIIGFVFRHEIKNSLKNNYEKALKQYNATGDYRSDAVDKIQSMLHCCGVTNYRDWKDTNYYSEKGFPESCCKLEDCSPQRDADKVNNEGCFIMVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV", "length": 245, "header": "sp|Q32KU6-1|TSN6_BOVIN Isoform 1 of Tetraspanin-6 OS=Bos taurus OX=9913 GN=TSPAN6 PE=2 SV=1 CANONICAL=Q32KU6-1" }, "locus": { "chromosome": "X", "start_pos": 49641060, "end_pos": 49637373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063874.2", "url": "https://www.ensembl.org/id/ENSBTAT00000063874.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056037.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056037.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 134, "start_aa": "Asn", "end_pos": 134, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn134", "evidence": [ { "id": "Q32KU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514741", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514741", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F7ESS4-1", "protein_name": "Tetraspanin", "gene_name": "Tspan6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIGTGTVIILLGTFGCFATCRASAWMLKLYAMFLTLIFLVELVAAIVGFVFRHEIKNSFKSNYENALKEYNSTRDYRSEAVDKIQSTLHCCGVTNYRDWKGTNYYSETGFPKSCCKLEGCYPQRDADKVNEEGCFIKVMTTIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV", "length": 245 }, "evidence": [ { "id": "Q32KU6", "url": "https://omabrowser.org/oma/group/Q32KU6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H5Y9-1", "protein_name": "Tetraspanin", "gene_name": "Tspan6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIGTGTVIILLGTFGCFATCRASAWMLKLYAMFLTLIFLVELVAAIVGFVFRHEIKNSFKNNYENALKEYNATRDYRSEAVDKIQSTLHCCGVTNYRDWKGTTYYSETGFPKSCCKLEGCSPQRDADKVNEEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV", "length": 245 }, "evidence": [ { "id": "Q32KU6", "url": "https://omabrowser.org/oma/group/Q32KU6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O43657-1", "protein_name": "Tetraspanin-6", "gene_name": "TSPAN6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV", "length": 245 }, "evidence": [ { "id": "Q32KU6", "url": "https://omabrowser.org/oma/group/Q32KU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ], "pmid": "" }, { "name": "negative regulation of cytoplasmic pattern recognition receptor signaling pathway", "id": "GO:0039532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039532", "evidence": [ { "database": "UniProtKB", "id": "Q32KU6", "url": "https://www.uniprot.org/uniprotkb/Q32KU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KU6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 245, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KU6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KU6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 134 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SWX0-1", "uniprot_ac": "Q3SWX0", "uniprot_id": "NIPA2_BOVIN", "mass": { "chemical_mass": 39036.0, "monoisotopic_mass": 39036.0 }, "refseq": { "ac": "NP_001029470", "name": "magnesium transporter NIPA2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470" }, "gene_names": [ { "name": "NIPA2", "type": "recommended", "evidence": [ { "id": "Q3SWX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ] }, { "name": "NIPA2", "type": "synonym", "evidence": [ { "id": "NP_001029470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470" } ] } ], "protein_names": [ { "name": "Magnesium transporter NIPA2", "type": "recommended", "evidence": [ { "id": "Q3SWX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0/entry#names_and_taxonomy" } ] }, { "name": "Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog", "type": "synonym", "evidence": [ { "id": "Q3SWX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0/entry#names_and_taxonomy" } ] }, { "name": "magnesium transporter NIPA2", "type": "synonym", "evidence": [ { "id": "NP_001029470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470" } ] }, { "name": "non imprinted in Prader-Willi/Angelman syndrome 2", "type": "synonym", "evidence": [ { "id": "NP_001029470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470" } ] }, { "name": "non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470" } ] } ], "function": [ { "annotation": "Acts as a selective Mg(2+) transporter.", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0#function" }, { "database": "UniProtKB", "id": "Q9JJC8", "url": "https://www.uniprot.org/uniprotkb/Q9JJC8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIPA2", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0", "locus": { "chromosome": "2", "start_pos": 1064844, "end_pos": 1044509, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016895", "url": "https://www.ensembl.org/id/ENSBTAG00000016895" } ] } } ], "crossref": [ { "id": "Q3SWX0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016895", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016895", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507430", "url": "https://www.ncbi.nlm.nih.gov/gene/507430", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507430", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507430", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMVYISI", "url": "https://omabrowser.org/oma/group/PMVYISI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SWX0", "url": "https://www.orthodb.org/?gene=Q3SWX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5223345", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29827", "url": "https://www.rhea-db.org/rhea/29827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF7A2B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A2B1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2B1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWX0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQGHGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSTRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVSLILIFVVGPRHGQTNILVYITICSVIGAVSVSCAKGLGIAIKELFAGKPVLQHPLTWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVITCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLSSLPVSFRKDEKAVNGSLSSMYEVLNNNEESLTCGIEQHTAENISRRNGNLTAF", "length": 360, "header": "sp|Q3SWX0-1|NIPA2_BOVIN Isoform 1 of Magnesium transporter NIPA2 OS=Bos taurus OX=9913 GN=NIPA2 PE=2 SV=1 CANONICAL=Q3SWX0-1" }, "isoforms": [ { "isoform_ac": "A0AAF7A2B1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0/entry#A0AAF7A2B1-1", "sequence": { "sequence": "MRIKGFIYEEMRMNKSSLTSSSLLFIRDHIKLTLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVSLILIFVVGPRHGQTNILVYITICSVIGAVSVSCAKGLGIAIKELFAGKPVLQHPLTWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVITCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLSSLPVSFRKDEKAVNGSLSSMYEVLNNNEESLTCGIEQHTAENISRRNGNLTAF", "length": 328, "header": "tr|A0AAF7A2B1-1|A0AAF7A2B1_BOVIN Computationally mapped isoform of NIPA magnesium transporter 2 OS=Bos taurus OX=9913 GN=NIPA2 PE=3 SV=1 CANONICAL=Q3SWX0-1" }, "locus": { "chromosome": "2", "start_pos": 1064792, "end_pos": 1045583, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080383.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080383.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062068.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062068.2" } ] } }, { "isoform_ac": "Q3SWX0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0/entry#Q3SWX0-1", "sequence": { "sequence": "MSQGHGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSTRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVSLILIFVVGPRHGQTNILVYITICSVIGAVSVSCAKGLGIAIKELFAGKPVLQHPLTWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVITCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLSSLPVSFRKDEKAVNGSLSSMYEVLNNNEESLTCGIEQHTAENISRRNGNLTAF", "length": 360, "header": "sp|Q3SWX0-1|NIPA2_BOVIN Isoform 1 of Magnesium transporter NIPA2 OS=Bos taurus OX=9913 GN=NIPA2 PE=2 SV=1 CANONICAL=Q3SWX0-1" }, "locus": { "chromosome": "2", "start_pos": 1064792, "end_pos": 1053489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079943.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079943.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067128.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507430", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507430", "resource": "KEGG Pathway" }, { "id": "R-BTA-5223345", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "resource": "Reactome", "description": "Miscellaneous transport and binding events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LHS3-1", "protein_name": "Magnesium transporter NIPA2", "gene_name": "Nipa2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLSEMSHKLGDPGFVVFATFVVIVAFIFIFVVGPRHGQTNILVYITICSMIGAFSVSCVKGLGITIKELLAGKPVLQHPLAWILLLSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLACSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAVNGSLSSMYEVLNNNEEGLPCGIEHTTGDTISRRNGNLTSF", "length": 360 }, "evidence": [ { "id": "Q3SWX0", "url": "https://omabrowser.org/oma/group/Q3SWX0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZUV1-1", "protein_name": "NIPA magnesium transporter 2", "gene_name": "Nipa2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGITIKELLAGKPVLQHPLAWILLLSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVTFRKDEKAVNGNLSNMYEVLNNNEEDLPCGIEHTGENISRRNGNLTSF", "length": 359 }, "evidence": [ { "id": "Q3SWX0", "url": "https://omabrowser.org/oma/group/Q3SWX0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NBX2-1", "protein_name": "Non imprinted in Prader-Willi/Angelman syndrome 2", "gene_name": "NIPA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQARGRYDFCIGLVLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSFFLNEKLNLHGKIGCLLSILGSTVMVIHAPQEEEVETLDEMSNKLRDPGFVVFATLVVIVSLILIVVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKELFAGKPVLKRPLSWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVIFTTSVLTCSAILFKEWQHMAADDIIGTFSGFLTIIVGIFLLHAFKDVNFTLANLPVSLRKDDRAANGSLLSTYDCFNHDEESSTCVSEIQSTESLSARRNGSLSAY", "length": 361 }, "evidence": [ { "id": "Q3SWX0", "url": "https://omabrowser.org/oma/group/Q3SWX0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8N8Q9-1", "protein_name": "Magnesium transporter NIPA2", "gene_name": "NIPA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSNMYEVLNNNEESLTCGIEQHTGENVSRRNGNLTAF", "length": 360 }, "evidence": [ { "id": "Q3SWX0", "url": "https://omabrowser.org/oma/group/Q3SWX0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJC8-1", "protein_name": "Magnesium transporter NIPA2", "gene_name": "Nipa2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLAGKPVLQHPLAWILLFSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSSMYEVLNNNEDDLPCGIEHTGENISRRNGNLPSF", "length": 359 }, "evidence": [ { "id": "Q3SWX0", "url": "https://omabrowser.org/oma/group/Q3SWX0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "magnesium ion transport", "id": "GO:0015693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015693", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX0", "url": "https://www.uniprot.org/uniprotkb/Q3SWX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29827", "name": "", "equation": "Mg(2+)(in) = Mg(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29827" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWX0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 360, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWX0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWX0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 244, "end_pos": 246 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 356, "end_pos": 358 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC34-1", "uniprot_ac": "Q3ZC34", "uniprot_id": "RBMS2_BOVIN", "mass": { "chemical_mass": 43820.0, "monoisotopic_mass": 43820.0 }, "refseq": { "ac": "NP_001029537", "name": "RNA-binding motif, single-stranded-interacting protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029537" }, "gene_names": [ { "name": "RBMS2", "type": "recommended", "evidence": [ { "id": "Q3ZC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ] }, { "name": "RBMS2", "type": "synonym", "evidence": [ { "id": "NP_001029537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029537" } ] } ], "protein_names": [ { "name": "RNA-binding motif, single-stranded-interacting protein 2", "type": "recommended", "evidence": [ { "id": "Q3ZC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif, single-stranded-interacting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001029537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029537" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBMS2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34", "locus": { "chromosome": "5", "start_pos": 56836859, "end_pos": 56889692, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017830", "url": "https://www.ensembl.org/id/ENSBTAG00000017830" } ] } } ], "crossref": [ { "id": "Q3ZC34", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017830", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017830", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12471", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12471", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12474", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12474", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509798", "url": "https://www.ncbi.nlm.nih.gov/gene/509798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509798", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509798", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PNASWMH", "url": "https://omabrowser.org/oma/group/PNASWMH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC34", "url": "https://www.orthodb.org/?gene=Q3ZC34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029537", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF7AF30", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AF30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AF30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AF30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Y8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Y8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC34-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPSSSTPNSSSGSTAHDQLSKTNLYIRGLQPSTTDQDLVKLCQSYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPSTALQNGFYPAPYNLAPNRMLTQSALSPYLPSPMTSYQRVTQTSPLQAPSPSWMHHQSYLMQPSGSVLTPGMDHPISLQPASMVGPLTQQLGHLSLSSTGTYVPTAAAMQGAYLSQYTPVPSSSVSVEESGSQQSQVPVDAPSEHGVYSFQFNK", "length": 407, "header": "sp|Q3ZC34-1|RBMS2_BOVIN Isoform 1 of RNA-binding motif, single-stranded-interacting protein 2 OS=Bos taurus OX=9913 GN=RBMS2 PE=2 SV=1 CANONICAL=Q3ZC34-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AF30-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34/entry#A0AAF7AF30-1", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPSSSTPNSSSGSTAHDQLSKTNLYIRGLQPSTTDQDLVKLCQSYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPSTALQNGFYPAPYNLAPNRMLTQSALSPYLPSPMTSYQYVPTAAAMQGAYLSQYTPVPSSSVSVEESGSQQSQVPVDAPSEHGVYSFQFNK", "length": 344, "header": "tr|A0AAF7AF30-1|A0AAF7AF30_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 2 OS=Bos taurus OX=9913 GN=RBMS2 PE=4 SV=1 CANONICAL=Q3ZC34-1" }, "locus": { "chromosome": "5", "start_pos": 56889622, "end_pos": 56837301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069723.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069723.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068222.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068222.2" } ] } }, { "isoform_ac": "A0ABI0P0Y8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34/entry#A0ABI0P0Y8-1", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPSSSTPNSSSGSTAHDQLSKTNLYIRGLQPSTTDQDLVKLCQSYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPSTALQNGFYPAPYNLAPNRMLTQSALSPYLPSPMTSYQRVTQTSPLQAPSPSWMHHQSYLMQPSGSVLTPGMDHPISLQPASMVGPLTQQLGHLSLSSTGTVKQDIPLINSCHTRNTCVRLLGLNTLG", "length": 381, "header": "tr|A0ABI0P0Y8-1|A0ABI0P0Y8_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 2 OS=Bos taurus OX=9913 GN=RBMS2 PE=4 SV=1 CANONICAL=Q3ZC34-1" }, "locus": { "chromosome": "5", "start_pos": 56889622, "end_pos": 56838390, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152712.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152712.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104238.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104238.1" } ] } }, { "isoform_ac": "Q3ZC34-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34/entry#Q3ZC34-1", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPSSSTPNSSSGSTAHDQLSKTNLYIRGLQPSTTDQDLVKLCQSYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPSTALQNGFYPAPYNLAPNRMLTQSALSPYLPSPMTSYQRVTQTSPLQAPSPSWMHHQSYLMQPSGSVLTPGMDHPISLQPASMVGPLTQQLGHLSLSSTGTYVPTAAAMQGAYLSQYTPVPSSSVSVEESGSQQSQVPVDAPSEHGVYSFQFNK", "length": 407, "header": "sp|Q3ZC34-1|RBMS2_BOVIN Isoform 1 of RNA-binding motif, single-stranded-interacting protein 2 OS=Bos taurus OX=9913 GN=RBMS2 PE=2 SV=1 CANONICAL=Q3ZC34-1" }, "locus": { "chromosome": "5", "start_pos": 56889622, "end_pos": 56837301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023705.4", "url": "https://www.ensembl.org/id/ENSBTAT00000023705.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023705.3", "url": "https://www.ensembl.org/id/ENSBTAP00000023705.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "site_lbl": "Ser106" }, { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "site_lbl": "Ser280" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "site_lbl": "Ser285" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509798", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509798", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JYJ7-1", "protein_name": "RNA binding motif, single stranded interacting protein 2", "gene_name": "Rbms2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKLYVAQQMAPPSPRNGTPNSSSGSGGNDQLSKTNLYIRGLQPSTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSSAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTTGASRGVGFARMESTEKCEAIITHFNGKYIKTPPGVAAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPTTALQNGFYTAPYSLAHSRMLAQSALAPYLPSPVSSYQRVTQTSPVQVPNTSWMQQQSYLMQPSGSVLTPGMDHPLSLQPASMMGPLTQQLGHLSLNSLGTFMPAAAAMQGTYISQYPAVPSSSVSVEESNGQQSQLAVEPPSDHGVYPFQFSK", "length": 405 }, "evidence": [ { "id": "Q3ZC34", "url": "https://omabrowser.org/oma/group/Q3ZC34/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A4X1W8B8-1", "protein_name": "RNA binding motif single stranded interacting protein 2", "gene_name": "RBMS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPSNSTPNSSNGSNVNDQLSKTNLYIRGLQPGTTDQDLVKLCQSYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGLALTYDPTTALQNGFYPAPYNITPNRMLSQSALSPYLPSPVSSYQRVTQTSPLQVPNPSWMHHQSYLMQPSGSVLTPGMDHPISLQPASMMGPLTQQLGHLSLSSMGTYMPAAAAVQGAYISQFTPVPSSSVSLEESGGQQSQVTAEAPSDHGVYSFQFNK", "length": 407 }, "evidence": [ { "id": "Q3ZC34", "url": "https://omabrowser.org/oma/group/Q3ZC34/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F5K2-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 2 isoform X1", "gene_name": "Rbms2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPRNSTPNSSSGSNGHDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVTAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPTTALPNGFYPTPYNIAHSRVLAQAALSPYLPSPVSSYQRLTQPSLQVPSPSWMQHQSYLMQPSVSVQKWADKETTGCKEKPRALMTGYVGGSVLTPGMDHPLSLQPASMMGPLTQQLGHLSLNSLGTFMPTAAAIQGAYIPQYPPGPSSNVSVEESSGQQNQVAVETPSDHGVYPFQFSK", "length": 433 }, "evidence": [ { "id": "Q3ZC34", "url": "https://omabrowser.org/oma/group/Q3ZC34/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q15434-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 2", "gene_name": "RBMS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSGSVLTPGMDHPISLQPASMMGPLTQQLGHLSLSSTGTYMPTAAAMQGAYISQYTPVPSSSVSVEESSGQQNQVAVDAPSEHGVYSFQFNK", "length": 407 }, "evidence": [ { "id": "Q3ZC34", "url": "https://omabrowser.org/oma/group/Q3ZC34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VC70-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 2", "gene_name": "Rbms2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLSVTSRPGISTFGYNKNNKKLYVAQQMAPPSPRNSTPNSSGGGGGGSGGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSSAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGASRGVGFARMESTEKCEAIITHFNGKYIKTPPGVAAPSDPLLCKFADGGPKKRQSQGRYVQNGRAWPRNGDMGGMALTYDPTAALQNGFYAAPYSIAHSRMLAQSALAPYLPSPVSSYQGSVLTPGMDHPLSLQPASMMGPLTQQLGHLSLNSLGTFMPAAAAMHGAYISQYPAVPSSSVSAEESNGQQNQLAVEPPSDHGVYPFQFSK", "length": 383 }, "evidence": [ { "id": "Q3ZC34", "url": "https://omabrowser.org/oma/group/Q3ZC34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC34", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 407, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 1", "eco_id": "ECO_0000255", "start_pos": 56, "end_pos": 129, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC34" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 2", "eco_id": "ECO_0000255", "start_pos": 135, "end_pos": 220, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 106, 280, 285 ], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9F5-1", "uniprot_ac": "Q5E9F5", "uniprot_id": "TAGL2_BOVIN", "mass": { "chemical_mass": 22426.0, "monoisotopic_mass": 22426.0 }, "refseq": { "ac": "NP_001013617", "name": "transgelin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013617" }, "gene_names": [ { "name": "TAGLN2", "type": "recommended", "evidence": [ { "id": "Q5E9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ] }, { "name": "TAGLN2", "type": "synonym", "evidence": [ { "id": "NP_001013617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013617" } ] } ], "protein_names": [ { "name": "Transgelin-2", "type": "recommended", "evidence": [ { "id": "Q5E9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5/entry#names_and_taxonomy" } ] }, { "name": "transgelin-2", "type": "synonym", "evidence": [ { "id": "NP_001013617", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013617" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAGLN2", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5", "locus": { "chromosome": "3", "start_pos": 9769006, "end_pos": 9761198, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002068", "url": "https://www.ensembl.org/id/ENSBTAG00000002068" } ] } } ], "crossref": [ { "id": "Q5E9F5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9F5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002068", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002068", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21280", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21280", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282379", "url": "https://www.ncbi.nlm.nih.gov/gene/282379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282379", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282379", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WIKTITG", "url": "https://omabrowser.org/oma/group/WIKTITG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9F5", "url": "https://www.orthodb.org/?gene=Q5E9F5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001013617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013617", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF7AGM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AGM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AGM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AGM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9F5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINGLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRYFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199, "header": "sp|Q5E9F5-1|TAGL2_BOVIN Isoform 1 of Transgelin-2 OS=Bos taurus OX=9913 GN=TAGLN2 PE=2 SV=3 CANONICAL=Q5E9F5-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AGM7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5/entry#A0AAF7AGM7-1", "sequence": { "sequence": "MSAFSLASAPRLGGVSPPQPLPPASGMANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINGLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRYFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 225, "header": "tr|A0AAF7AGM7-1|A0AAF7AGM7_BOVIN Computationally mapped isoform of Transgelin OS=Bos taurus OX=9913 GN=TAGLN2 PE=1 SV=1 CANONICAL=Q5E9F5-1" }, "locus": { "chromosome": "3", "start_pos": 9768352, "end_pos": 9763215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080925.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080925.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068950.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068950.2" } ] } }, { "isoform_ac": "Q5E9F5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5/entry#Q5E9F5-1", "sequence": { "sequence": "MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINGLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRYFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199, "header": "sp|Q5E9F5-1|TAGL2_BOVIN Isoform 1 of Transgelin-2 OS=Bos taurus OX=9913 GN=TAGLN2 PE=2 SV=3 CANONICAL=Q5E9F5-1" }, "locus": { "chromosome": "3", "start_pos": 9768352, "end_pos": 9766742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002674.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002674.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002674.2", "url": "https://www.ensembl.org/id/ENSBTAP00000002674.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "site_lbl": "Ser11" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "site_lbl": "Ser163" }, { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "site_lbl": "Thr180" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:282379", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282379", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VV05-1", "protein_name": "Transgelin", "gene_name": "TAGLN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINGLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H7Z2-1", "protein_name": "Transgelin", "gene_name": "Tagln2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MANRGPAYGLSREVQQKIEKQYDGDLEQILIQWITTQCRKPVDRPQPGRENFHNWLKDGTVLCELINSLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEAKNMACVQRTLMNLGGLAVARNDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P37802-1", "protein_name": "Transgelin-2", "gene_name": "TAGLN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q08873-1", "protein_name": "Transgelin", "gene_name": "SCP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSYDKKADVTSLDEDLRQLRESKFSPEAIQNIKIWVYKSVLKEIAPPGDLLECLKDGTVLCKLANILYEADTGEANHISWKSSKMPFVQMDQISQFLSFSRKYGVPEDELFQTIDLFEKKDPAIVFQTLKSLSRYANKKHTDRFPVLGPQLSTKKPRPPVKSKPKHLQDGTGWSTFEYGYMKGASQATEGVVLGQRRDIV", "length": 200 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5XFX0-1", "protein_name": "Transgelin-2", "gene_name": "Tagln2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANRGPSYGLSREVQQKIEKQYDPDLEQILIQWITTQCRKGVSQPQPGRENFQNWLKDGTVLCELINSLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VZI1-1", "protein_name": "Transgelin", "gene_name": "Chd64", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASNRAAKSGFAAEAQRKINSKYSEELAQESLEWIKAVTEEPINTSGDTDNFFEVLKDGVILCKLANALQPGSIKKINESKMAFKCMENISAFLACAKNFGVPTQETFQSVDLWERQNLNSVVICLQSLGRKASNFNKPSIGPKEADKNVRNFSDEQLRAGANVISLQYGSNKGATQSGINFGNTRHM", "length": 188 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WVA4-1", "protein_name": "Transgelin-2", "gene_name": "Tagln2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANRGPSYGLSREVQQKIEKQYDADLEQILIQWITTQCREDVGQPQPGRENFQKWLKDGTVLCKLINSLYPEGQAPVKKIQASSMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL", "length": 199 }, "evidence": [ { "id": "Q5E9F5", "url": "https://omabrowser.org/oma/group/Q5E9F5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F5", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9F5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 199, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9F5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9F5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F5" }, { "id": "PRU00044", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 136, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11, 163, 180 ], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PD0-1", "uniprot_ac": "Q32PD0", "uniprot_id": "FCF1_BOVIN", "mass": { "chemical_mass": 23370.0, "monoisotopic_mass": 23370.0 }, "refseq": { "ac": "NP_001032529", "name": "rRNA-processing protein FCF1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529" }, "gene_names": [ { "name": "FCF1", "type": "recommended", "evidence": [ { "id": "Q32PD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ] }, { "name": "C14orf111", "type": "synonym", "evidence": [ { "id": "NP_001032529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529" } ] }, { "name": "FCF1", "type": "synonym", "evidence": [ { "id": "NP_001032529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529" } ] } ], "protein_names": [ { "name": "rRNA-processing protein FCF1 homolog", "type": "recommended", "evidence": [ { "id": "Q32PD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD0/entry#names_and_taxonomy" } ] }, { "name": "FCF1 small subunit", "type": "synonym", "evidence": [ { "id": "NP_001032529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529" } ] }, { "name": "rRNA-processing protein FCF1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001032529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529" } ] } ], "function": [ { "annotation": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHY1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHY1#function" }, { "database": "UniProtKB", "id": "ARBA00035000", "url": "https://www.uniprot.org/uniprotkb/ARBA00035000#function" }, { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0#function" }, { "database": "UniProtKB", "id": "Q9Y324", "url": "https://www.uniprot.org/uniprotkb/Q9Y324#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FCF1", "url": "https://www.uniprot.org/uniprotkb/Q32PD0", "locus": { "chromosome": "10", "start_pos": 85998914, "end_pos": 85988488, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020381", "url": "https://www.ensembl.org/id/ENSBTAG00000020381" } ] } } ], "crossref": [ { "id": "Q32PD0", "url": "https://alphafold.ebi.ac.uk/entry/Q32PD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020381", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020381", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09864", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09864", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508270", "url": "https://www.ncbi.nlm.nih.gov/gene/508270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508270", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508270", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GMMDCLL", "url": "https://omabrowser.org/oma/group/GMMDCLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PD0", "url": "https://www.orthodb.org/?gene=Q32PD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04900", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04900", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF7AHY1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKQKKTRKYATMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 198, "header": "sp|Q32PD0-1|FCF1_BOVIN Isoform 1 of rRNA-processing protein FCF1 homolog OS=Bos taurus OX=9913 GN=FCF1 PE=2 SV=1 CANONICAL=Q32PD0-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AHY1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD0/entry#A0AAF7AHY1-1", "sequence": { "sequence": "VFVITLLHSPVGGKRFVIIFERQRLSLSCVPAPDNSSIFERKNGKTPAAAAAAAAKLLQSCPTLCDPIDSSPPGSPVLGFSSKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 256, "header": "tr|A0AAF7AHY1-1|A0AAF7AHY1_BOVIN Computationally mapped isoform of rRNA-processing protein FCF1 homolog OS=Bos taurus OX=9913 GN=FCF1 PE=3 SV=1 CANONICAL=Q32PD0-1" }, "locus": { "chromosome": "10", "start_pos": 85998836, "end_pos": 85989787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070689.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070689.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069268.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069268.2" } ] } }, { "isoform_ac": "Q32PD0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD0/entry#Q32PD0-1", "sequence": { "sequence": "MGKQKKTRKYATMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 198, "header": "sp|Q32PD0-1|FCF1_BOVIN Isoform 1 of rRNA-processing protein FCF1 homolog OS=Bos taurus OX=9913 GN=FCF1 PE=2 SV=1 CANONICAL=Q32PD0-1" }, "locus": { "chromosome": "10", "start_pos": 85998836, "end_pos": 85988520, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027167.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027167.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027167.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027167.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508270", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508270", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RUD3-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "FCF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGKQKKARKYAVMKRMISLRDHRINEKDRAKAPAKKKEDPSAIKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQRYRVALRIAKDPRFERLPCMHKGTYADDCLVQRVTQHKCYIVATVDKELKRRIRKIPGVPIMYISRHRYNIERMPDDYGAPRF", "length": 198 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TD48-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "FCF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKQKKTRKYAIMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 198 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MDU6-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Fcf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 198 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O82346-1", "protein_name": "PIN domain-like family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGKAKKPQKFAVVKKMISHKALKHYKEEVLNPNKKDLTELPRNVPSVPAGLFFSYNSTLVPPYRVLVDTNFINFSIQNKIDLEKGMRDCLYANCTPCITDCVMAELEKLGQKYRVALRIAKDPHFERLPCIHKGTYADDCLVDRVTQHKCFIVATCDRDLKRRIRKIPGVPIMYVTNRKYSIEKLPEATLGGAPRY", "length": 196 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q05498-1", "protein_name": "rRNA-processing protein FCF1", "gene_name": "FCF1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGKAKKTRKFGLVKRTLNTKKDQRLKKNQENIKTKEDPELTRNIPQVSSALFFQYNQAIKPPYQVLIDTNFINFSIQKKVDIVRGMMDCLLAKCNPLITDCVMAELEKLGPKYRIALKLARDPRIKRLSCSHKGTYADDCLVHRVLQHKCYIVATNDAGLKQRIRKIPGIPLMSVGGHAYVIEKLPDVF", "length": 189 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q1RP75-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Fcf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "GKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYLSNHRYNIERMPDDYGAPRF", "length": 197 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55GM5-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "fcf1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MARKPGLAPKKVPLQKLNKTNPNFSNRQKQIQRSKQEDEHRKKLEEIPEDNTSHMFFSYNEALVPPYHVIIDTNFINFSISHKLDIIHSLMDCLYAKCIPYISDCVAAEIERLGSKFKVALKISKDPRFQRLTCSHKGTYADDCIINRITMHRMFIVATCDADLRRRIRKIPGVPIVYLKGKKYTVERMPDLLQ", "length": 194 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CTH6-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Fcf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKFRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYLSNHRYNIERMPDDYGAPRF", "length": 198 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VL75-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Bka", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGKHKKTQKVKKQRNAQLKRIIKPTDARLKDQIRVKRKKAEDPHQIKVHEATQQSSALFFQYNTQLGPPYHIVLDTNFINFSIKNKLDIVQGMMDCLYAKCIPYISDCVRAELEKLGNKYKLALRIISDPRFERLPCLHKGTYADDCLVERVRQHKCYIVATNDKDLKNRIRKIPGVPIMYVAAHKYAIERMPEAYGVKA", "length": 200 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y324-1", "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "FCF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKQKKTRKYATMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF", "length": 198 }, "evidence": [ { "id": "Q32PD0", "url": "https://omabrowser.org/oma/group/Q32PD0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q32PD0", "url": "https://www.uniprot.org/uniprotkb/Q32PD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PD0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PD0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PD0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHH6-1", "uniprot_ac": "Q3MHH6", "uniprot_id": "PYRD2_BOVIN", "mass": { "chemical_mass": 62987.0, "monoisotopic_mass": 62987.0 }, "refseq": { "ac": "NP_001029704", "name": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704" }, "gene_names": [ { "name": "PYROXD2", "type": "recommended", "evidence": [ { "id": "Q3MHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6" } ] }, { "name": "C10orf33", "type": "synonym", "evidence": [ { "id": "NP_001029704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704" } ] }, { "name": "C26H10orf33", "type": "synonym", "evidence": [ { "id": "NP_001029704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704" } ] }, { "name": "PYROXD2", "type": "synonym", "evidence": [ { "id": "NP_001029704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704" } ] } ], "protein_names": [ { "name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q3MHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#names_and_taxonomy" } ] }, { "name": "1.-.-.-", "type": "synonym", "evidence": [ { "id": "Q3MHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#names_and_taxonomy" } ] }, { "name": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001029704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704" } ] } ], "function": [ { "annotation": "Probable oxidoreductase that may play a role as regulator of mitochondrial function.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6#function" }, { "database": "UniProtKB", "id": "Q8N2H3", "url": "https://www.uniprot.org/uniprotkb/Q8N2H3#function" }, { "database": "UniProtKB", "id": "A0AAF7ANF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ANF5#function" }, { "database": "UniProtKB", "id": "ARBA00037217", "url": "https://www.uniprot.org/uniprotkb/ARBA00037217#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQS4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQS4#function" }, { "database": "UniProtKB", "id": "F1MN72", "url": "https://www.uniprot.org/uniprotkb/F1MN72#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PYROXD2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6", "locus": { "chromosome": "26", "start_pos": 19468910, "end_pos": 19494297, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014313", "url": "https://www.ensembl.org/id/ENSBTAG00000014313" } ] } } ], "crossref": [ { "id": "Q3MHH6", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014313", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014313", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519120", "url": "https://www.ncbi.nlm.nih.gov/gene/519120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519120", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519120", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GLYHCGS", "url": "https://omabrowser.org/oma/group/GLYHCGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQS4", "url": "https://www.orthodb.org/?gene=A0A3Q1LQS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MN72", "url": "https://www.orthodb.org/?gene=F1MN72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHH6", "url": "https://www.orthodb.org/?gene=Q3MHH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10668", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10668", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10668:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10668:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13450", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13450", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029704", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQS4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ANF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ANF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ANF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ANF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN72", "url": "https://www.uniprot.org/uniprotkb/F1MN72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN72-1", "url": "https://www.uniprot.org/uniprotkb/F1MN72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTICGRGLRRAVGASPRPTWRRALSDTRGRLKPEYDAVVVGAGHNGLVAAAYLQRFGVNTAVFERRHVIGGAAVTEEIVPGFKFSRASYLLSLLRPQIYSELELKKHGLRLHLRNPYSFTPMLEEGTGGKVPRSLLLGTDMVENQKQIAQFSKKDAQAFPKYEAFMDRLALAIDPLLDSAPVDLEAFQRGSLLQRLKSLSTLKPLWQAGCILGAQLPQYYQVLTAPAAKVLDQWFESEPLKATLATDAVIGAMTNPYIPGSGYVLLHHVMGSLEGVRGAWGYVQGGMGALSDAIASSATAHGVSIFTEKTVAKVQVSSGGRVQGVVLQDGSEVRSKVVLSNASPQITFLKLTPQEWLPEEFVARIAQLDTKSPVTKINVAVNRLPDFLAAPNTPGDQPLPHHQCSIHLNCEDTLLVHQAFEDTLDGLPSKRPLIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKAWDEQQRNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERVFGLPGGNIFHCAMSLDQLYFARPVPLHSSYCSPLRGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLRSM", "length": 581, "header": "sp|Q3MHH6-1|PYRD2_BOVIN Isoform 1 of Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PYROXD2 PE=2 SV=1 CANONICAL=Q3MHH6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQS4-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#A0A3Q1LQS4-1", "sequence": { "sequence": "MTICGRGLRRAVGASPRPTWRRALSDTRGRLKPEYDAVVVGAGHNGLVAAAYLQRFGVNTAVFERRHVIGGAAVTEEIVPGFKFSRASYLLSLLRPQIYSELELKAFPKYEAFMDRLALAIDPLLDSAPVDLEAFQRGSLLQRLKSLSTLKPLWQAGCILGAQLPQYYQVLTAPAAKVLDQWFESEPLKATLATDAVIGAMTNPYIPGSGYVLLHHVMGSLEGVRGAWGYVQGGMGALSDAIASSATAHGVSIFTEKTVAKVQVSSGGRVQGVVLQDGSEVRSKVVLSNASPQITFLKLTPQEWLPEEFVARIAQLDTKSPVTKINVAVNRLPDFLAAPNTPGDQPLPHHQCSIHLNCEDTLLVHQAFEDTLDGLPSKRPLIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKAWDEQQRNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERVFGLPGGNIFHCAMSLDQLYFARPVPLHSSYCSPLRGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLRSM", "length": 529, "header": "tr|A0A3Q1LQS4-1|A0A3Q1LQS4_BOVIN Computationally mapped isoform of Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PYROXD2 PE=3 SV=1 CANONICAL=Q3MHH6-1" }, "locus": {} }, { "isoform_ac": "A0AAF7ANF5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#A0AAF7ANF5-1", "sequence": { "sequence": "MTICGRGLRRAVGASPRPTWRRALSDTRGRLKPEYDAVVVGAGKVGWAGAAYLQRFGVNTAVFERRHVIGGAAVTEEIVPGFKFSRASYLLSLLRPQIYSELELKKHGLRLHLRNPYSFTPMLEEGTGGKVPRSLLLGTDMVENQKQIAQFSKKDAQAFPKYEAFMDRLALAIDPLLDSAPVDLEAFQRGSLLQRLKSLSTLKPLWQAGCILGAQLPQYYQVLTAPAAKVLDQWFESEPLKATLATDAVIGAMTNPYIPGSGYVLLHHVMGSLEGVRGAWGYVQGGMGALSDAIASSATAHGVSIFTEKTVAKVQVSSGGRVQGVVLQDGSEVRSKVVLSNASPQITFLKLTPQEWLPEEFVARIAQLDTKSPVTKINVAVNRLPDFLAAPNTPGDQPLPHHQCSIHLNCEDTLLVHQAFEDTLDGLPSKRPLIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKAWDEQQRNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERVFGLPGGNIFHCAMSLDQLYFARPVPLHSSYCSPLRGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLRSM", "length": 581, "header": "tr|A0AAF7ANF5-1|A0AAF7ANF5_BOVIN Computationally mapped isoform of Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PYROXD2 PE=3 SV=1 CANONICAL=Q3MHH6-1" }, "locus": { "chromosome": "26", "start_pos": 19494232, "end_pos": 19469098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072106.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072106.2" } ] } }, { "isoform_ac": "F1MN72-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#F1MN72-1", "sequence": { "sequence": "MTICGRGLRRAVGASPRPTWRRALSDTRGRLKPEYDAVVVGAGKVGWAGAAYLQRFGVNTAVFERRHVIGGAAVTEEIVPGFKFSRASYLLSLLRPQIYSELELKKHGLRLHLRNPYSFTPMLEEGTGGKVPRSLLLGTDMVENQKQIAQFSKKDAQAFPKYEAFMDRLALAIDPLLDSAPVDLEAFQRGSLLQRLKSLSTLKPLWQAGCILGAQLGVLDQWFESEPLKATLATDAVIGAMTNPYIPGSGYVLLHHVMGSLEGVRGAWGYVQGGMGALSDAIASSATAHGVSIFTEKTVAKVQVSSGGRVQGVVLQDGSEVRSKVVLSNASPQITFLKLTPQEWLPEEFVARIAQLDTKSPVTKINVAVNRLPDFLAAPNTPGDQPLPHHQCSIHLNCEDTLLVHQAFEDTLDGLPSKRPLIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKAWDEQQRNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERVFGLPGGNIFHCAMSLDQLYFARPVPLHSSYCSPLRGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLRSM", "length": 569, "header": "tr|F1MN72-1|F1MN72_BOVIN Computationally mapped isoform of Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PYROXD2 PE=3 SV=2 CANONICAL=Q3MHH6-1" }, "locus": { "chromosome": "26", "start_pos": 19494232, "end_pos": 19469098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032952.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032952.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032879.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032879.3" } ] } }, { "isoform_ac": "Q3MHH6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6/entry#Q3MHH6-1", "sequence": { "sequence": "MTICGRGLRRAVGASPRPTWRRALSDTRGRLKPEYDAVVVGAGHNGLVAAAYLQRFGVNTAVFERRHVIGGAAVTEEIVPGFKFSRASYLLSLLRPQIYSELELKKHGLRLHLRNPYSFTPMLEEGTGGKVPRSLLLGTDMVENQKQIAQFSKKDAQAFPKYEAFMDRLALAIDPLLDSAPVDLEAFQRGSLLQRLKSLSTLKPLWQAGCILGAQLPQYYQVLTAPAAKVLDQWFESEPLKATLATDAVIGAMTNPYIPGSGYVLLHHVMGSLEGVRGAWGYVQGGMGALSDAIASSATAHGVSIFTEKTVAKVQVSSGGRVQGVVLQDGSEVRSKVVLSNASPQITFLKLTPQEWLPEEFVARIAQLDTKSPVTKINVAVNRLPDFLAAPNTPGDQPLPHHQCSIHLNCEDTLLVHQAFEDTLDGLPSKRPLIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKAWDEQQRNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERVFGLPGGNIFHCAMSLDQLYFARPVPLHSSYCSPLRGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLRSM", "length": 581, "header": "sp|Q3MHH6-1|PYRD2_BOVIN Isoform 1 of Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PYROXD2 PE=2 SV=1 CANONICAL=Q3MHH6-1" }, "locus": { "chromosome": "26", "start_pos": 19494232, "end_pos": 19469098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079932.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079932.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059457.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059457.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:519120", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519120", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1Q815-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "pyroxd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVSVRAGRAHRAFISVTQRCSHSSTALKPQYDAVIIGAGHNGLIASAYLQKGGLRTAVLERRHVLGGAAVSEEIIPGFHFSRASYLLSLLRPHIYQDLELKKHGLKVYMRDPYSFTPMLEDGVGGRPPRSLLLGSDLTNTRQEIGKFSEKDAKVYPDFLRYLETLACAIHPLLDAPPVDIPGLTQGSLTKRLSALRSLKPLVKSGLKLGKNIPDFYELVTAPAMKVLNRWFESEPLIATLATDSVIGANTSPNNPGSGYVLLHHVMGELEKEKGSWGYVEGGMGGVPQSIARSARSLGADIFTNTDVEQVLIGPDGSAKGVVLTDGTEVHSKVVLSNATPHVTFKRLTPQDALPEAFITAVDQIDYTSPVTKINVAVDKLPDFLAAPNGADGKAGPHHQCSIHLNCESVEVLEDAYWEGQHGRPSSRPMIEMTIPSVLDPTLAPPGCHVVSLFIQFTPYLLEGRRAWTDEDKERFGDTVFDWVERYAPGFKASIVGKDILTPADLERVFGLTGGNIFHGSMSLDQLYLARPLPSIADYRSPVKGLYLCGSGSHPGGGVMGAAGWSSALRVLADFKRL", "length": 578 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S8W9-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "PYROXD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAACGQGFSRAVRASPHPAWRQAHSDTTRGRLKSEYDAVVIGAGHNGLVAVAYLQRLGVNTVVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLRLHLRNPYSFTPMLEEGTGGKVPRSLLLGTDMAENQKQIAQFSRKDAQAFPKYEAFMNRLALAIEPLLDAAPVDMEAFQRGSLLQRLKSLSTFKPLLQAGRTLGAQLPQYYQVLTAPSVKVLDQWFESEPLKATLATDAVIGAMTSPHIPGSGYVLLHHVMGGLEGMRGAWAYVEGGMGALSEAIASSATAHGASIFTEKTVASVQVSSGGRVQGVVLQDGSEVRSRVVLSNASPQSTFLKLTPQEWLPEEFVQRISQLDTQSPVTKINVAVNRLPNFLAAPNTPRGQPLPHHQCSTHLNCEDTLRIHQAFEDAVDGLPSHRPIIELCIPSSLDPTLAPPGCHVISLFTQYTPYTLAGGKAWDELERNTYADRVFDCIEAYAPGFKGSVVGRDILTPPDLERIFDLPGGNIFHCAMTLDQLYFARPVPLHSSYRCPLPGLYLCGSGAHPGGGVMGAAGRNAARVVFRDLRSM", "length": 582 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4K658-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MWRRSFSTLPKKKWDAVVIGGGHNGLTAAAYLARGGLSVAVLERRHVIGGAAVTEEIVPGFKFSRCSYLQGLLRPCIIRELELGRHGLKLLKRSPSSFTPCLDGRYLLLGPDQDLNHSEISKFSKHDADAYPRYEKQLERFCGFMDPLLDSTPPESLQSASSFNDKLSNKMYKSAFWARCLRQAVSLGHKDMVAFMDLLLAPASKVLNNWFESDVLKASLATDAVIGSTASVHTPGSGYVLLHHVMGETDGEKGIWSYVEGGMGSVSMAIANAAKEAGAEIFTNAEVSEILTEDSSIVKGVLLADGTRVESSAILSNATPYRTYVELVPTNVLPENFVSAIKNSDYSSATTKINLAVDKLPQFQCCNTNHSGPGPEHFGTIHIGAESMDEVHSACHDSENGLPSRRPVIEMTIPSTLDNTISPPGKHVINLFIQYTPYKPSDGSWEDPTYREAFAQRCFKLIDEYAPGFSSSIISYDMLTPPDLEREIGLTGGNIFHGAMGLDSLFLMRPVKGWSNYRSPLKGLYLCGSGAHPGGGVMGAPGRNAAHVVLQDLKRI", "length": 556 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q3U4I7-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "Pyroxd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGGRGLIRALHSSPCPTWKRAQSGANGRLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQICTDLELKKHGLKLHLRDPYSFTPMLEEGTLNRLPRSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPVDTTAFQHGSLLQRLRALSTLKPLLKAGRTLGAQLPQYYEVLTAPISKVLDQRFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGTQGAWSYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVNSEGRAQGVTLQDGEEVRSRVVLSCASPQVTFLELTPQEWLPGAFVKRISQLDTQSPVTKINVAVDRLPNFQAAPNAPGDQPQGHHQCSIHLNCEDTLLLHQAFEDAKGGLPSQKPMIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKVWNEQEKNTYADKVFDCIEAYAPGFKRSVLARDILTPPDLERIFRLPGGNIFHGAMSLDQLYFARPVPQHSDYRCPVQGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLKNM", "length": 581 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q68FT3-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "Pyroxd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASGRGLSRALHSTPCPAWKRVQSGANGCLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLKLHLRNPYSFTPMLEEGTLSKPPRSLLLGTDVAENQKQISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPVDIAALQHGSLLQRLRALSTLRPLLKAGRTLGAQLPQYYEVLTAPISKVLDQWFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGMQGAWSYVQGGMGALSDAIASSATAHGASIFTEKTVAKVQVNSEGRVQGVVLQGGEEVRSRVVLSCASPQVTFLELTPQEWLPGAFVKRISQLDTQSPVTKINVAVDRLPNFQAAPNAPGDQPQAHHQCSIHLNCEDTLLLHQAFEDAKGGLPSQRPMIELCIPSSLDPTLAPTGCHVVSLFTQYTPYTLAGGKVWDEQKKNTYADKVFDCIEAYAPGFKRSVLGRDILTPQDLERIFGLPGGNIFHGAMSLDQLYFARPVPQHSDYRCPVQGLYLCGSGAHPGGGVMGAAGRNAAHIVFRDLKNM", "length": 581 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N2H3-1", "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "PYROXD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASGRGLCKAVAASPFPAWRRDNTEARGGLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLRLHLRNPYSFTPMLEEGAGSKVPRCLLLGTDMAENQKQIAQFSQKDAQVFPKYEEFMHRLALAIDPLLDAAPVDMAAFQHGSLLQRMRSLSTLKPLLKAGRILGAQLPRYYEVLTAPITKVLDQWFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGGLEGMQGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVNSEGCVQGVVLEDGTEVRSKMVLSNTSPQITFLKLTPQEWLPEEFLERISQLDTRSPVTKINVAVDRLPSFLAAPNAPRGQPLPHHQCSIHLNCEDTLLLHQAFEDAMDGLPSHRPVIELCIPSSLDPTLAPPGCHVVSLFTQYMPYTLAGGKAWDEQERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPDLERIFGLPGGNIFHCAMSLDQLYFARPVPLHSGYRCPLQGLYLCGSGAHPGGGVMGAAGRNAAHVAFRDLKSM", "length": 581 }, "evidence": [ { "id": "Q3MHH6", "url": "https://omabrowser.org/oma/group/Q3MHH6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH6", "url": "https://www.uniprot.org/uniprotkb/Q3MHH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 581, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHH6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 341, "end_pos": 343 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIK2-1", "uniprot_ac": "Q2KIK2", "uniprot_id": "MP17L_BOVIN", "mass": { "chemical_mass": 22328.0, "monoisotopic_mass": 22328.0 }, "refseq": { "ac": "NP_001040067", "name": "mpv17-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" }, "gene_names": [ { "name": "MPV17L", "type": "recommended", "evidence": [ { "id": "Q2KIK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ] }, { "name": "MPV17L", "type": "synonym", "evidence": [ { "id": "NP_001040067", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" } ] } ], "protein_names": [ { "name": "Mpv17-like protein", "type": "recommended", "evidence": [ { "id": "Q2KIK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2/entry#names_and_taxonomy" } ] }, { "name": "M-LP homolog", "type": "synonym", "evidence": [ { "id": "NP_001040067", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" }, { "id": "Q2KIK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2/entry#names_and_taxonomy" } ] }, { "name": "M-LPH", "type": "synonym", "evidence": [ { "id": "NP_001040067", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" }, { "id": "Q2KIK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2/entry#names_and_taxonomy" } ] }, { "name": "MPV17 mitochondrial membrane protein-like", "type": "synonym", "evidence": [ { "id": "NP_001040067", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" } ] }, { "name": "mpv17-like protein", "type": "synonym", "evidence": [ { "id": "NP_001040067", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067" } ] } ], "function": [ { "annotation": "Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Protective against the mitochondrial apoptotic cascade.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2#function" }, { "database": "UniProtKB", "id": "Q2QL34", "url": "https://www.uniprot.org/uniprotkb/Q2QL34#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPV17L", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2", "locus": { "chromosome": "25", "start_pos": 13822182, "end_pos": 13816668, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047520", "url": "https://www.ensembl.org/id/ENSBTAG00000047520" } ] } } ], "crossref": [ { "id": "Q2KIK2", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "617491", "url": "https://www.ncbi.nlm.nih.gov/gene/617491", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617491", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617491", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIK2", "url": "https://www.orthodb.org/?gene=Q2KIK2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040067", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIK2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSWWQALTRAAGRYPWPANVLLYAGFFSGGDALQQVLRGGPADWQHTRHVATVAVAFHANLNYVWLNLLERALPGRAPRTILAKVLCDQALGGPVYVSTFYAGMSILQGKDDIFLDMRQKFWNTYKSGLMYWPFVQLINFSLIPIRWRTAYTGLCGFLWATFLCFSQQEGDGTFKSAFTFRRIKVTNEVEKPSEK", "length": 196, "header": "sp|Q2KIK2-1|MP17L_BOVIN Isoform 1 of Mpv17-like protein OS=Bos taurus OX=9913 GN=MPV17L PE=2 SV=1 CANONICAL=Q2KIK2-1" }, "isoforms": [ { "isoform_ac": "Q2KIK2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2/entry#Q2KIK2-1", "sequence": { "sequence": "MVSWWQALTRAAGRYPWPANVLLYAGFFSGGDALQQVLRGGPADWQHTRHVATVAVAFHANLNYVWLNLLERALPGRAPRTILAKVLCDQALGGPVYVSTFYAGMSILQGKDDIFLDMRQKFWNTYKSGLMYWPFVQLINFSLIPIRWRTAYTGLCGFLWATFLCFSQQEGDGTFKSAFTFRRIKVTNEVEKPSEK", "length": 196, "header": "sp|Q2KIK2-1|MP17L_BOVIN Isoform 1 of Mpv17-like protein OS=Bos taurus OX=9913 GN=MPV17L PE=2 SV=1 CANONICAL=Q2KIK2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617491", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617491", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901029", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK2", "url": "https://www.uniprot.org/uniprotkb/Q2KIK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIK2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIK3-1", "uniprot_ac": "Q2KIK3", "uniprot_id": "SIM14_BOVIN", "mass": { "chemical_mass": 10773.0, "monoisotopic_mass": 10773.0 }, "refseq": { "ac": "NP_001040008", "name": "small integral membrane protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" }, "gene_names": [ { "name": "SMIM14", "type": "recommended", "evidence": [ { "id": "Q2KIK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3" } ] }, { "name": "C4orf34", "type": "synonym", "evidence": [ { "id": "NP_001040008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" } ] }, { "name": "C6H4orf34", "type": "synonym", "evidence": [ { "id": "NP_001040008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" } ] }, { "name": "SMIM14", "type": "synonym", "evidence": [ { "id": "NP_001040008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 14", "type": "recommended", "evidence": [ { "id": "Q2KIK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3/entry#names_and_taxonomy" } ] }, { "name": "small integral membrane protein 14", "type": "synonym", "evidence": [ { "id": "NP_001040008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" } ] }, { "name": "uncharacterized protein C4orf34 homolog", "type": "synonym", "evidence": [ { "id": "NP_001040008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIK3", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM14", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3", "locus": { "chromosome": "6", "start_pos": 58631894, "end_pos": 58690833, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014522", "url": "https://www.ensembl.org/id/ENSBTAG00000014522" } ] } } ], "crossref": [ { "id": "Q2KIK3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014522", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014522", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614774", "url": "https://www.ncbi.nlm.nih.gov/gene/614774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614774", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ACTDTEC", "url": "https://omabrowser.org/oma/group/ACTDTEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIK3", "url": "https://www.orthodb.org/?gene=Q2KIK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31019:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31019:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040008", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z064", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z064", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z064-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z064-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIK3", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIK3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQELPGPSSDNGISITMILMAWMVIAVILFLLRPPNLRGSNLTGKPASPHNGQDPPAPPVD", "length": 99, "header": "sp|Q2KIK3-1|SIM14_BOVIN Isoform 1 of Small integral membrane protein 14 OS=Bos taurus OX=9913 GN=SMIM14 PE=3 SV=1 CANONICAL=Q2KIK3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z064-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3/entry#A0AAF6Z064-1", "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQEWTRSTSPSCGLTLWIWEVKIV", "length": 62, "header": "tr|A0AAF6Z064-1|A0AAF6Z064_BOVIN Computationally mapped isoform of Small integral membrane protein 14 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=Q2KIK3-1" }, "locus": { "chromosome": "6", "start_pos": 58662403, "end_pos": 58632930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019303.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019303.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019303.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019303.4" } ] } }, { "isoform_ac": "Q2KIK3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3/entry#Q2KIK3-1", "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQELPGPSSDNGISITMILMAWMVIAVILFLLRPPNLRGSNLTGKPASPHNGQDPPAPPVD", "length": 99, "header": "sp|Q2KIK3-1|SIM14_BOVIN Isoform 1 of Small integral membrane protein 14 OS=Bos taurus OX=9913 GN=SMIM14 PE=3 SV=1 CANONICAL=Q2KIK3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614774", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614774", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QMS3-1", "protein_name": "Small integral membrane protein 14", "gene_name": "SMIM14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQELPGPSSDNGISITMILMAWMVIAVILFLLRPPNLRGSNLTGKPTSPHNGQDPPAPPVD", "length": 99 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YVD2-1", "protein_name": "Small integral membrane protein 14", "gene_name": "SMIM14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLAISAASAHSPPPPSRAQRAPPPPLPLDNSRPHQNGGGCRACAVFTEKFRFIQGTMAEGGFDPCECICSHEHAMRRLINLLRQSQSYCTDTECLQELPGPNYSGDNVVSFAMVVMAWVVIAFVLFLLRPSNLRNSSAAGKPTSPHNGQEPPAPPLD", "length": 157 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IBF9-1", "protein_name": "Small integral membrane protein 14", "gene_name": "Smim14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEGGFDPCECICSHEHAMRRLINLLRQSQSYCTDTECLRELPGPSSDSGVSITVILMAWMVIAVLLFLLRPPNLRGSSLPGKPSSPHSGQDPPAPPVD", "length": 99 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q0E8W6-1", "protein_name": "Small integral membrane protein 14", "gene_name": "BcDNA:AT28250", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDDFDGCECVWSQEYAMQRLINFIRQNQNACGDNECYDVTGRTPHQAQIAGRGDDSGFSVAMIFLIVAMFMYIVNPSTWGNFTSNKRAGGRRDNNQDGSPPQPPPPAIN", "length": 110 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q498C7-1", "protein_name": "Small integral membrane protein 14", "gene_name": "Smim14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEGGFDPCECICSHEHAMRRLINLLRQSQSYCTDTECLRELPGPSGDSGISITVILMAWMVIAVLLFLLRPPNLRGSSLPGKPSSPHSGQDPPAPPVD", "length": 99 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91VT8-1", "protein_name": "Small integral membrane protein 14", "gene_name": "Smim14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLRELPGPSSDSGISITVILMAWMVIAMLLFLLRPPNLRGSSLPGKPSSPHSGQDPPAPPVD", "length": 99 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96QK8-1", "protein_name": "Small integral membrane protein 14", "gene_name": "SMIM14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQELPGPSGDNGISVTMILVAWMVIALILFLLRPPNLRGSSLPGKPTSPHNGQDPPAPPVD", "length": 99 }, "evidence": [ { "id": "Q2KIK3", "url": "https://omabrowser.org/oma/group/Q2KIK3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK3", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2KIK3", "url": "https://www.uniprot.org/uniprotkb/Q2KIK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIK3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 99, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIK3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIK3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIL5-1", "uniprot_ac": "Q2KIL5", "uniprot_id": "PDIA5_BOVIN", "mass": { "chemical_mass": 59673.0, "monoisotopic_mass": 59673.0 }, "refseq": { "ac": "NP_001039556", "name": "protein disulfide-isomerase A5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039556" }, "gene_names": [ { "name": "PDIA5", "type": "recommended", "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ] }, { "name": "PDIA5", "type": "synonym", "evidence": [ { "id": "NP_001039556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039556" } ] } ], "protein_names": [ { "name": "Protein disulfide-isomerase A5", "type": "recommended", "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5/entry#names_and_taxonomy" } ] }, { "name": "5.3.4.1", "type": "synonym", "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5/entry#names_and_taxonomy" } ] }, { "name": "protein disulfide-isomerase A5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039556" } ] }, { "name": "protein disulfide-isomerase A5", "type": "synonym", "evidence": [ { "id": "NP_001039556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039556" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDIA5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5", "locus": { "chromosome": "1", "start_pos": 67504230, "end_pos": 67411388, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018877", "url": "https://www.ensembl.org/id/ENSBTAG00000018877" } ] } } ], "crossref": [ { "id": "Q2KIL5", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018877", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018877", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02997", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02997", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511603", "url": "https://www.ncbi.nlm.nih.gov/gene/511603", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511603", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FCKKMKP", "url": "https://omabrowser.org/oma/group/FCKKMKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIL5", "url": "https://www.orthodb.org/?gene=Q2KIL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45672", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45672", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45672:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45672:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039556", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIL5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARVVPAWLLLPLAVWVVLPTWLSSAKFSSLIERISDPKDLKKLLRTRNNVLVLYSKSEAAAESHLKLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSAKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHIDNEKDFRRLLKKEEKPILMMFYAPWCSVCKRIMPHFQKAATQLRGQFVLAGMNVYPSEFENIKEEYSVRGYPTICYFEKGRFLFQYDSYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLSDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGEGDSSGVLAAVDATVNKALAERFHIAEFPTLKYFKNGEKYAVPALRTKKSFIEWMRNPESPPPPDPAWEEQQTSVLHLSGDNFRETLKRKKHALVMFYAPWCPHCKKAIPHFTAAADAFKDDRKIACAAIDCVKENNKDLCQQEAVKAYPTFHYYHYGKFVEKYDTNPTELGFTSFIRTLREGDHERLGKKKEEL", "length": 521, "header": "sp|Q2KIL5-1|PDIA5_BOVIN Isoform 1 of Protein disulfide-isomerase A5 OS=Bos taurus OX=9913 GN=PDIA5 PE=2 SV=1 CANONICAL=Q2KIL5-1" }, "isoforms": [ { "isoform_ac": "Q2KIL5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5/entry#Q2KIL5-1", "sequence": { "sequence": "MARVVPAWLLLPLAVWVVLPTWLSSAKFSSLIERISDPKDLKKLLRTRNNVLVLYSKSEAAAESHLKLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSAKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHIDNEKDFRRLLKKEEKPILMMFYAPWCSVCKRIMPHFQKAATQLRGQFVLAGMNVYPSEFENIKEEYSVRGYPTICYFEKGRFLFQYDSYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLSDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGEGDSSGVLAAVDATVNKALAERFHIAEFPTLKYFKNGEKYAVPALRTKKSFIEWMRNPESPPPPDPAWEEQQTSVLHLSGDNFRETLKRKKHALVMFYAPWCPHCKKAIPHFTAAADAFKDDRKIACAAIDCVKENNKDLCQQEAVKAYPTFHYYHYGKFVEKYDTNPTELGFTSFIRTLREGDHERLGKKKEEL", "length": 521, "header": "sp|Q2KIL5-1|PDIA5_BOVIN Isoform 1 of Protein disulfide-isomerase A5 OS=Bos taurus OX=9913 GN=PDIA5 PE=2 SV=1 CANONICAL=Q2KIL5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511603", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511603", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SQ40-1", "protein_name": "Protein disulfide-isomerase A5", "gene_name": "PDIA5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLWQTWHRELGGGERLGSGGGCCTRRCCGRGSPRGDRSRPWAAAAGMARVGPAWLLLLAVWVVLPAWLSSTKVSSLIEKISDPKDLKKLLRTRNNVLVLYSKSEAAAESHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSAKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKKEEKPILMMFYASWCSVCKRIMPHFQKAATQLRGQFVLAGMNVYSSEFENIKEEYGVRGYPTICYFEKGRFLFQYDSYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFENAAEVLHGEADSSGVLAAVDATVHKALAERFHISEFPTLKYFKNGEKYAVPALRTKKNFVEWMRNPEAPPPPDPTWEEQQTSVLHLSGDNFRETLKRKKHTLVMFYAPWCPHCKKVIPHFTATADVFKDDRKIACAAVDCIKEKNQDLCQQEAVKAYPTFHYYHYGKLAEKYDSDRTELGFTSFIRTLREGDHERLGKKKEEL", "length": 566 }, "evidence": [ { "id": "Q2KIL5", "url": "https://omabrowser.org/oma/group/Q2KIL5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14554-1", "protein_name": "Protein disulfide-isomerase A5", "gene_name": "PDIA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAAENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL", "length": 519 }, "evidence": [ { "id": "Q2KIL5", "url": "https://omabrowser.org/oma/group/Q2KIL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5I0H9-1", "protein_name": "Protein disulfide-isomerase A5", "gene_name": "Pdia5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARAWGLLLAIGVILPTWLSSTKVSSLIERISDPKDLKKLLRTRNNVLVLYSESEVAAESHLKLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKKEEKPLLMMFYAPWCSMCKRIMPHFQKAATQVRGHTVLAGMNVYPPEFENIKEEYNVRGYPTICYFEKGRFLFQYENYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATINEALAERFHISAFPTLKYFKNGEQQAVPALRTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQESVKAYPTFHYYHYGKLVEKYESDRTELGFTSFIRTLREGDLKRLEKRREDL", "length": 517 }, "evidence": [ { "id": "Q2KIL5", "url": "https://omabrowser.org/oma/group/Q2KIL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q921X9-1", "protein_name": "Protein disulfide-isomerase A5", "gene_name": "Pdia5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARAWGLLLAIGVVLPTWLSSTKVSSLIERISDPKDLKKLLRTRNNVLVLYSESEVAAESHLKLLSTVAQAVKGQGTVCWVDCGDAESRKLCKKMKVDLSPKDKKIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKREEKPLLMMFYAPWCSMCKRIMPHFQKAATQVRGHIVLAGMNVYPSEFENIKEEYNVRGYPTICYFEKGRFLFPYENYGSTAEDIVEWLKNPLPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATVNEALAGRFHISAFPTLKYFKNGEQQAVPALRTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRDTLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKEDRKIACAAVDCVKDKNQDLCQQEAVKAYPTFHYYHYGKLVEKYESDRTELGFTSFIRTLREGDLKRLEKRREEL", "length": 517 }, "evidence": [ { "id": "Q2KIL5", "url": "https://omabrowser.org/oma/group/Q2KIL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VJZ1-1", "protein_name": "Thioredoxin domain-containing protein", "gene_name": "anon-WO0118547.80", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MWITGQFVFLLLVALVAAKSKTSAVQDDIAEYKDFKKLLRTKNNVLALYVTSAKSAAAELKIFREAAEAIRGTGTMLLLDCGQQDRKKLCKKLKVSPDPYAIKHYKDGDFHKDYDRQLSVSSMITFMRDPSGDLPWEEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFTYEGENNKEALVSFMLNPNAKPTPKPKEPEWSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLAALDATKEPSIAEKYKVKGYPTVKFFSNGVFKFEVNVREASKIVEFMRDPKEPPPPPPPEKSWEEEEDSKEVLFLDDDNFSSTLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCAKYNVRGYPTILYFSYLKTKLDYNGGRTSKDFIAYMNNPPTSADRTEL", "length": 510 }, "evidence": [ { "id": "Q2KIL5", "url": "https://omabrowser.org/oma/group/Q2KIL5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein disulfide isomerase activity", "id": "GO:0003756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003756", "evidence": [ { "database": "UniProtKB", "id": "Q2KIL5", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 521, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" }, { "id": "PRU10138", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10138" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Prevents secretion from ER", "eco_id": "ECO_0000255", "start_pos": 518, "end_pos": 521, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" }, { "id": "PRU00691", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00691" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin 1", "eco_id": "ECO_0000255", "start_pos": 136, "end_pos": 263, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" }, { "id": "PRU00691", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00691" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin 2", "eco_id": "ECO_0000255", "start_pos": 274, "end_pos": 386, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KIL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIL5" }, { "id": "PRU00691", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00691" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin 3", "eco_id": "ECO_0000255", "start_pos": 387, "end_pos": 508, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.3.4.1", "ec_name": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "5.3.4.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.4.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIM1-1", "uniprot_ac": "Q2KIM1", "uniprot_id": "ADSSP_BOVIN", "mass": { "chemical_mass": 19559.0, "monoisotopic_mass": 19559.0 }, "refseq": { "ac": "NP_001039670", "name": "adipose-secreted signaling protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" }, "gene_names": [ { "name": "ADISSP", "type": "recommended", "evidence": [ { "id": "Q2KIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ] }, { "name": "ADISSP", "type": "synonym", "evidence": [ { "id": "NP_001039670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" } ] }, { "name": "C13H20orf27", "type": "synonym", "evidence": [ { "id": "NP_001039670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" } ] } ], "protein_names": [ { "name": "Adipose-secreted signaling protein", "type": "recommended", "evidence": [ { "id": "Q2KIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1/entry#names_and_taxonomy" } ] }, { "name": "UPF0687 protein C20orf27 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" } ] }, { "name": "adipose-secreted signaling protein", "type": "synonym", "evidence": [ { "id": "NP_001039670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" } ] }, { "name": "chromosome 13 C20orf27 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670" } ] } ], "function": [ { "annotation": "Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1#function" }, { "database": "UniProtKB", "id": "Q9D1K7", "url": "https://www.uniprot.org/uniprotkb/Q9D1K7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADISSP", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1", "locus": { "chromosome": "13", "start_pos": 51443739, "end_pos": 51430704, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018735", "url": "https://www.ensembl.org/id/ENSBTAG00000018735" } ] } } ], "crossref": [ { "id": "Q2KIM1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018735", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018735", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515589", "url": "https://www.ncbi.nlm.nih.gov/gene/515589", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515589", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515589", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GVRCIGM", "url": "https://omabrowser.org/oma/group/GVRCIGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIM1", "url": "https://www.orthodb.org/?gene=Q2KIM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13287", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13287", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13287:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13287:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15006", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15006", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039670", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P1W3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1W3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIM1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAANKGNKSRVRSIRFATSHDAESSQSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVRETPVPSLHLKLLSVMPIPEGYSVKCEYSAHKEGVLKEEMLLACEGGSDTCVRVIVQARVMDRHHGTPMLLDGVRCVGAELEYDSEHSDWRGFD", "length": 174, "header": "sp|Q2KIM1-1|ADSSP_BOVIN Isoform 1 of Adipose-secreted signaling protein OS=Bos taurus OX=9913 GN=ADISSP PE=2 SV=1 CANONICAL=Q2KIM1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P1W3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1/entry#A0ABI0P1W3-1", "sequence": { "sequence": "EAAAPSRRSRVRSIRFATSHDAESSQSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVRETPVPSLHLKLLSVMPIPEGYSVKCEYSAHKEGVLKEEMLLACEGGSDTCVRVIVQARVMDRHHGTPMLLDGVRCVGAELEYDSEHSDWRGFD", "length": 173, "header": "tr|A0ABI0P1W3-1|A0ABI0P1W3_BOVIN Computationally mapped isoform of Adipose-secreted signaling protein OS=Bos taurus OX=9913 GN=ADISSP PE=3 SV=1 CANONICAL=Q2KIM1-1" }, "locus": { "chromosome": "13", "start_pos": 51443194, "end_pos": 51438696, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150921.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150921.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104997.1" } ] } }, { "isoform_ac": "Q2KIM1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1/entry#Q2KIM1-1", "sequence": { "sequence": "MAAANKGNKSRVRSIRFATSHDAESSQSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVRETPVPSLHLKLLSVMPIPEGYSVKCEYSAHKEGVLKEEMLLACEGGSDTCVRVIVQARVMDRHHGTPMLLDGVRCVGAELEYDSEHSDWRGFD", "length": 174, "header": "sp|Q2KIM1-1|ADSSP_BOVIN Isoform 1 of Adipose-secreted signaling protein OS=Bos taurus OX=9913 GN=ADISSP PE=2 SV=1 CANONICAL=Q2KIM1-1" }, "locus": { "chromosome": "13", "start_pos": 51443194, "end_pos": 51438004, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024937.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024937.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024937.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024937.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "site_lbl": "Thr147" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515589", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515589", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJN3-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "ADISSP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAANKGNKPRVRSIRFATGHDAEGSQSHVHFDEKLHDSVVMVSQESESSFLVKVGFLKILHRYEITFTLPPVHRLSKDVREAPVPSLHLKLLSVMPIPEGYSVKCEYSAHKEGVLKEEMLLACEGGTGTCVRVVVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD", "length": 174 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H427-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "C6H20orf27", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAANRGNKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPSVRRLSKDIREAPVHSLHLKLLSVTPIPEGYSIKCEYSAHKEGVLKEEMLLACEGDTGTCVRVMVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD", "length": 174 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KM45-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "Adissp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAANRGSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPAVRRLSKDIREAPVHSLHLKLLSVTPIPEGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVHVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD", "length": 174 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D1K7-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "Adissp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAANRGSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPPVRRLSKDIRETPVHSLHLKLLSVTPTSEGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEQSDWLGFD", "length": 174 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GZN8-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "ADISSP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAANKGNKPRVRSIRFAAGHDAEGSHSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVREAPVPSLHLKLLSVVPVPEGYSVKCEYSAHKEGVLKEEILLACEGGTGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD", "length": 174 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VSK4-1", "protein_name": "Adipose-secreted signaling protein", "gene_name": "Dmel\\CG6983", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCDESIENVEHQDHHVHFDTNTVKDDFESDSCVTYQRSGDTIVVSLGFLQIRHRYLIELKLPTSLFGDAKTLASKFEPVISATPSLHCRITEFEGTKHDEHDFFEMKIEFFAYKEKLLREVLHIVSSSNAKELLQLVIAARVLGKGKGTPMLRTGIHCIGVERDDDESEASDFAGFDSKP", "length": 180 }, "evidence": [ { "id": "Q2KIM1", "url": "https://omabrowser.org/oma/group/Q2KIM1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" }, { "name": "adaptive thermogenesis", "id": "GO:1990845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990845", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase 1 binding", "id": "GO:0008157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008157", "evidence": [ { "database": "UniProtKB", "id": "Q2KIM1", "url": "https://www.uniprot.org/uniprotkb/Q2KIM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 174, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIM1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 147 ], "sequon_annotation_sites": [ { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIN1-1", "uniprot_ac": "Q2KIN1", "uniprot_id": "DPM2_BOVIN", "mass": { "chemical_mass": 9395.0, "monoisotopic_mass": 9395.0 }, "refseq": { "ac": "NP_001039733", "name": "dolichol phosphate-mannose biosynthesis regulatory protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" }, "gene_names": [ { "name": "DPM2", "type": "recommended", "evidence": [ { "id": "Q2KIN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ] }, { "name": "DPM2", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" } ] } ], "protein_names": [ { "name": "Dolichol phosphate-mannose biosynthesis regulatory protein", "type": "recommended", "evidence": [ { "id": "Q2KIN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1/entry#names_and_taxonomy" } ] }, { "name": "DPM synthase subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" }, { "id": "Q2KIN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1/entry#names_and_taxonomy" } ] }, { "name": "Dolichol-phosphate mannose synthase subunit 2", "type": "synonym", "evidence": [ { "id": "Q2KIN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1/entry#names_and_taxonomy" } ] }, { "name": "dolichol phosphate-mannose biosynthesis regulatory protein", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" } ] }, { "name": "dolichol-phosphate mannose synthase subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" } ] }, { "name": "dolichyl-phosphate mannosyltransferase 2", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" } ] }, { "name": "dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit", "type": "synonym", "evidence": [ { "id": "NP_001039733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733" } ] } ], "function": [ { "annotation": "Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1#function" }, { "database": "UniProtKB", "id": "O94777", "url": "https://www.uniprot.org/uniprotkb/O94777#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPM2", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1", "locus": { "chromosome": "11", "start_pos": 98600692, "end_pos": 98603745, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003388", "url": "https://www.ensembl.org/id/ENSBTAG00000003388" } ] } } ], "crossref": [ { "id": "Q2KIN1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "523737", "url": "https://www.ncbi.nlm.nih.gov/gene/523737", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523737", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523737", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIN1", "url": "https://www.orthodb.org/?gene=Q2KIN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15039", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15039", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15039:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15039:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039733", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIN1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATGTDQVVGLGLVALSLIIFTYYTAWVILLPFIDSQHVIHKYFLPRAYAIAIPLAAGHLLLLFVGIFITYVMLKNQNDTKKTQ", "length": 84, "header": "sp|Q2KIN1-1|DPM2_BOVIN Isoform 1 of Dolichol phosphate-mannose biosynthesis regulatory protein OS=Bos taurus OX=9913 GN=DPM2 PE=3 SV=3 CANONICAL=Q2KIN1-1" }, "isoforms": [ { "isoform_ac": "Q2KIN1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1/entry#Q2KIN1-1", "sequence": { "sequence": "MATGTDQVVGLGLVALSLIIFTYYTAWVILLPFIDSQHVIHKYFLPRAYAIAIPLAAGHLLLLFVGIFITYVMLKNQNDTKKTQ", "length": 84, "header": "sp|Q2KIN1-1|DPM2_BOVIN Isoform 1 of Dolichol phosphate-mannose biosynthesis regulatory protein OS=Bos taurus OX=9913 GN=DPM2 PE=3 SV=3 CANONICAL=Q2KIN1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523737", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523737", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "id": "GO:0000506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000506", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" }, { "name": "dolichol-phosphate-mannose synthase complex", "id": "GO:0033185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033185", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme regulator activity", "id": "GO:0030234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030234", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" }, { "name": "dolichol phosphate mannose biosynthetic process", "id": "GO:0180047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180047", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIN1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 84, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIN1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIN1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIN6-1", "uniprot_ac": "Q2KIN6", "uniprot_id": "MPV17_BOVIN", "mass": { "chemical_mass": 19586.0, "monoisotopic_mass": 19586.0 }, "refseq": { "ac": "NP_001039394", "name": "mitochondrial inner membrane protein Mpv17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394" }, "gene_names": [ { "name": "MPV17", "type": "recommended", "evidence": [ { "id": "Q2KIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ] }, { "name": "MPV17", "type": "synonym", "evidence": [ { "id": "NP_001039394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394" } ] } ], "protein_names": [ { "name": "Mitochondrial inner membrane protein Mpv17", "type": "recommended", "evidence": [ { "id": "Q2KIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#names_and_taxonomy" } ] }, { "name": "MPV17, mitochondrial inner membrane protein", "type": "synonym", "evidence": [ { "id": "NP_001039394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394" } ] }, { "name": "Protein Mpv17", "type": "synonym", "evidence": [ { "id": "Q2KIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial inner membrane protein Mpv17", "type": "synonym", "evidence": [ { "id": "NP_001039394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394" } ] }, { "name": "protein Mpv17", "type": "synonym", "evidence": [ { "id": "NP_001039394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394" } ] } ], "function": [ { "annotation": "Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6#function" }, { "database": "UniProtKB", "id": "P39210", "url": "https://www.uniprot.org/uniprotkb/P39210#function" }, { "database": "UniProtKB", "id": "P19258", "url": "https://www.uniprot.org/uniprotkb/P19258#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPV17", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6", "locus": { "chromosome": "11", "start_pos": 72335057, "end_pos": 72325001, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018269", "url": "https://www.ensembl.org/id/ENSBTAG00000018269" } ] } } ], "crossref": [ { "id": "Q2KIN6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018269", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018269", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505763", "url": "https://www.ncbi.nlm.nih.gov/gene/505763", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505763", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505763", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WYQSKLA", "url": "https://omabrowser.org/oma/group/WYQSKLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIK0", "url": "https://www.orthodb.org/?gene=A0A3Q1MIK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIU8", "url": "https://www.orthodb.org/?gene=A0A452DIU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIN6", "url": "https://www.orthodb.org/?gene=Q2KIN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039394", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIU8", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIU8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNA5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNA5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIN6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRDFPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 176, "header": "sp|Q2KIN6-1|MPV17_BOVIN Isoform 1 of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=2 SV=1 CANONICAL=Q2KIN6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIK0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#A0A3Q1MIK0-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRDFPDALITNYYLWPAVQLANFYLVPLHYREDLSTALISIPPGLSL", "length": 170, "header": "tr|A0A3Q1MIK0-1|A0A3Q1MIK0_BOVIN Computationally mapped isoform of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=3 SV=2 CANONICAL=Q2KIN6-1" }, "locus": { "chromosome": "11", "start_pos": 72333231, "end_pos": 72325461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086308.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086308.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070553.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070553.2" } ] } }, { "isoform_ac": "A0A452DIU8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#A0A452DIU8-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRVSWPGLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 170, "header": "tr|A0A452DIU8-1|A0A452DIU8_BOVIN Computationally mapped isoform of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=3 SV=3 CANONICAL=Q2KIN6-1" }, "locus": { "chromosome": "11", "start_pos": 72334021, "end_pos": 72325461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024316.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024316.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024316.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024316.7" } ] } }, { "isoform_ac": "A0AAA9TPD8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#A0AAA9TPD8-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRDFPDALITNYYVGCGPVCCCYLELLPVLEGTSALSRLHPITSAL", "length": 169, "header": "tr|A0AAA9TPD8-1|A0AAA9TPD8_BOVIN Computationally mapped isoform of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=3 SV=2 CANONICAL=Q2KIN6-1" }, "locus": { "chromosome": "11", "start_pos": 72334053, "end_pos": 72325461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132892.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132892.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098883.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098883.2" } ] } }, { "isoform_ac": "A0AAF7A7G6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#A0AAF7A7G6-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVDFPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 113, "header": "tr|A0AAF7A7G6-1|A0AAF7A7G6_BOVIN Computationally mapped isoform of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=3 SV=2 CANONICAL=Q2KIN6-1" }, "locus": { "chromosome": "11", "start_pos": 72334021, "end_pos": 72325461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085989.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085989.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064043.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064043.3" } ] } }, { "isoform_ac": "A0ABI0NNA5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#A0ABI0NNA5-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRVSWPGVGMLSGWWTGRPGGMMQGRVEMQAEPSSGGEELGGCGAVVSSLSRNLCVILMPVGSWHQEV", "length": 191, "header": "tr|A0ABI0NNA5-1|A0ABI0NNA5_BOVIN Computationally mapped isoform of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=3 SV=1 CANONICAL=Q2KIN6-1" }, "locus": { "chromosome": "11", "start_pos": 72332557, "end_pos": 72325461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148855.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148855.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106788.1" } ] } }, { "isoform_ac": "Q2KIN6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6/entry#Q2KIN6-1", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQAHQAGRTLTMASLGCGFVGPVVGGWYRVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLQRDFPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 176, "header": "sp|Q2KIN6-1|MPV17_BOVIN Isoform 1 of Mitochondrial inner membrane protein Mpv17 OS=Bos taurus OX=9913 GN=MPV17 PE=2 SV=1 CANONICAL=Q2KIN6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505763", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505763", "resource": "KEGG Pathway" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AZQ7-1", "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "MPV17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALWRAYQRALTAHPWKVQVLTAGSLMGLGDVISQQLVERRGLQEHQTGRTLTMVSLGCGFVGPVVGGWYKVLDRLIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGTLNGLSAQDNWAKLRRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 176 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P19258-1", "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "Mpv17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF", "length": 176 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P39210-1", "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "MPV17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQEHQRGRTLTMVSLGCGFVGPVVGGWYKVLDRFIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGALNGLSAQDNWAKLQRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL", "length": 176 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5BK62-1", "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "Mpv17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQQHQTGRTLTMASLGCGFVGPVVGGWYRVLDHLIPGTTKVNALKKMLLDQGGFAPCFLGCFLPLVGVLNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVVWNSYLSWKAHQL", "length": 176 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5TZ51-1", "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "mpv17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGLWRSYQALMAKHPWKVQIITAGSLVGVGDVISQQLIERRGLANHNARRTAKMMSIGFFFVGPVVGGWYKVLDKLVTGGTKSAALKKMLVDQVGFAPCFLGAFLGITGTLNGLTVEENVAKLQRDYTDALISNYYLWPPVQIANFYFIPLHHRLAVVQIVAVVWNSYLSWKANKM", "length": 177 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9LV46-1", "protein_name": "Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLKLWRWYQRCLTVHPVKTQVISSGFLWGFGDVTAQYITHSTAKRRLLRLTETNKDADADAEIKVKWKQDAEFKVNWKRVAITSMFGFGFVGPVGHFWYEGLDKFIKLKLRYVPKSTRFVAAKVAMDGLIFGPVDLLVFFTYMGFATGKNTAEVKEGLKRDFLPALALEGGAWPLLQIANFRYVPVQYQLLYVNIFCLVDSAFLSWVEQQKDAAWKQWFTSSFQPLKERGGQGGV", "length": 235 }, "evidence": [ { "id": "Q2KIN6", "url": "https://omabrowser.org/oma/group/Q2KIN6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "channel activity", "id": "GO:0015267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015267", "evidence": [ { "database": "UniProtKB", "id": "Q2KIN6", "url": "https://www.uniprot.org/uniprotkb/Q2KIN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIN6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIN6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIN6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIP5-1", "uniprot_ac": "Q2KIP5", "uniprot_id": "PDZ1I_BOVIN", "mass": { "chemical_mass": 12269.0, "monoisotopic_mass": 12269.0 }, "refseq": { "ac": "NP_001039986", "name": "PDZK1-interacting protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039986" }, "gene_names": [ { "name": "PDZK1IP1", "type": "recommended", "evidence": [ { "id": "Q2KIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5" } ] }, { "name": "MAP17", "type": "synonym", "evidence": [ { "id": "Q2KIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5" } ] }, { "name": "PDZK1IP1", "type": "synonym", "evidence": [ { "id": "NP_001039986", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039986" } ] } ], "protein_names": [ { "name": "PDZK1-interacting protein 1", "type": "recommended", "evidence": [ { "id": "Q2KIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5/entry#names_and_taxonomy" } ] }, { "name": "PDZK1-interacting protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039986", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039986" } ] } ], "function": [ { "annotation": "Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1 (By similarity). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP5", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5#function" }, { "database": "UniProtKB", "id": "Q13113", "url": "https://www.uniprot.org/uniprotkb/Q13113#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIP5", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDZK1IP1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5", "locus": { "chromosome": "3", "start_pos": 99062244, "end_pos": 99043980, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002555", "url": "https://www.ensembl.org/id/ENSBTAG00000002555" } ] } } ], "crossref": [ { "id": "Q2KIP5", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "613915", "url": "https://www.ncbi.nlm.nih.gov/gene/613915", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613915", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIP5", "url": "https://www.orthodb.org/?gene=Q2KIP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15296:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15296:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039986", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIP5", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIP5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVLSLVVLSLLMALPPASCQQGRGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQEKPAPINMVMTIGNKADGILVGTDGKYSSMAASFRSSEHENAYENIPEEEGKVCSTPM", "length": 114, "header": "sp|Q2KIP5-1|PDZ1I_BOVIN Isoform 1 of PDZK1-interacting protein 1 OS=Bos taurus OX=9913 GN=PDZK1IP1 PE=3 SV=1 CANONICAL=Q2KIP5-1" }, "isoforms": [ { "isoform_ac": "Q2KIP5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5/entry#Q2KIP5-1", "sequence": { "sequence": "MSVLSLVVLSLLMALPPASCQQGRGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQEKPAPINMVMTIGNKADGILVGTDGKYSSMAASFRSSEHENAYENIPEEEGKVCSTPM", "length": 114, "header": "sp|Q2KIP5-1|PDZ1I_BOVIN Isoform 1 of PDZK1-interacting protein 1 OS=Bos taurus OX=9913 GN=PDZK1IP1 PE=3 SV=1 CANONICAL=Q2KIP5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP5", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5" } ], "site_lbl": "Ser85" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613915", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613915", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q2KIP5", "url": "https://www.uniprot.org/uniprotkb/Q2KIP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIP5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 114, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIP5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIP5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 85 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIR4-1", "uniprot_ac": "Q2KIR4", "uniprot_id": "RP25L_BOVIN", "mass": { "chemical_mass": 17770.0, "monoisotopic_mass": 17770.0 }, "refseq": { "ac": "NP_001039576", "name": "ribonuclease P protein subunit p25-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" }, "gene_names": [ { "name": "RPP25L", "type": "recommended", "evidence": [ { "id": "Q2KIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ] }, { "name": "C8H9orf23", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] }, { "name": "C9orf23", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] }, { "name": "RPP25L", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] } ], "protein_names": [ { "name": "Ribonuclease P protein subunit p25-like protein", "type": "recommended", "evidence": [ { "id": "Q2KIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4/entry#names_and_taxonomy" } ] }, { "name": "RNase P protein subunit-like p25", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" }, { "id": "Q2KIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4/entry#names_and_taxonomy" } ] }, { "name": "Rpp25-like protein", "type": "synonym", "evidence": [ { "id": "Q2KIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4/entry#names_and_taxonomy" } ] }, { "name": "alba-like protein C9orf23 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] }, { "name": "ribonuclease P protein subunit p25-like protein", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] }, { "name": "rpp25-like protein", "type": "synonym", "evidence": [ { "id": "NP_001039576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576" } ] } ], "function": [ { "annotation": "May be a component of ribonuclease P or MRP.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPP25L", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4", "locus": { "chromosome": "8", "start_pos": 75975776, "end_pos": 75980347, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016295", "url": "https://www.ensembl.org/id/ENSBTAG00000016295" } ] } } ], "crossref": [ { "id": "Q2KIR4", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016295", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016295", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512203", "url": "https://www.ncbi.nlm.nih.gov/gene/512203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512203", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512203", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNLPVIW", "url": "https://omabrowser.org/oma/group/RNLPVIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIR4", "url": "https://www.orthodb.org/?gene=Q2KIR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13516", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13516", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13516:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13516:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01918", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01918", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039576", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIR4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRAGSKIRNLLGLALERLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLYQLTKLRFLQTEDSWVPTSPDTGLDPLTVRSHVPAVWVLLSRDPLDPNEYGYQPPGAPPDLGPTPASSCGPQPRRRARDTRF", "length": 163, "header": "sp|Q2KIR4-1|RP25L_BOVIN Isoform 1 of Ribonuclease P protein subunit p25-like protein OS=Bos taurus OX=9913 GN=RPP25L PE=2 SV=1 CANONICAL=Q2KIR4-1" }, "isoforms": [ { "isoform_ac": "Q2KIR4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4/entry#Q2KIR4-1", "sequence": { "sequence": "MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRAGSKIRNLLGLALERLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLYQLTKLRFLQTEDSWVPTSPDTGLDPLTVRSHVPAVWVLLSRDPLDPNEYGYQPPGAPPDLGPTPASSCGPQPRRRARDTRF", "length": 163, "header": "sp|Q2KIR4-1|RP25L_BOVIN Isoform 1 of Ribonuclease P protein subunit p25-like protein OS=Bos taurus OX=9913 GN=RPP25L PE=2 SV=1 CANONICAL=Q2KIR4-1" }, "locus": { "chromosome": "8", "start_pos": 75979305, "end_pos": 75978817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021677.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021677.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021677.2", "url": "https://www.ensembl.org/id/ENSBTAP00000021677.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 145, "start_aa": "Thr", "end_pos": 145, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr145", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512203", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y2F2-1", "protein_name": "Ribonuclease P/MRP subunit p25 like", "gene_name": "RPP25L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MENYKKTKIVEKPCPLPFTDLPPDIIEMKVKDGSKIRNLMGYAIGKMELDSVRQILFTGSGKAVSKTITCVEIMKRRLKELHQITKVLFKQIEEIWEPIVPEAGLDALTVKRNIPAICVLLSKDALDPQEPGYQAPGSFDAFWIETLKAESQAQMKRKQVECLGSPEQSPETERLVGVAWGFYRNQPAALAGKLLLNTGLQSC", "length": 203 }, "evidence": [ { "id": "Q2KIR4", "url": "https://omabrowser.org/oma/group/Q2KIR4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SEB9-1", "protein_name": "Ribonuclease P protein subunit p25-like protein", "gene_name": "RPP25L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPTSPDTGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGPMPSSSCGPRPRRRARDTRF", "length": 163 }, "evidence": [ { "id": "Q2KIR4", "url": "https://omabrowser.org/oma/group/Q2KIR4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N5L8-1", "protein_name": "Ribonuclease P protein subunit p25-like protein", "gene_name": "RPP25L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPASPDTGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGSMPSSSCGPRSRRRARDTRS", "length": 163 }, "evidence": [ { "id": "Q2KIR4", "url": "https://omabrowser.org/oma/group/Q2KIR4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99JH1-1", "protein_name": "Ribonuclease P protein subunit p25-like protein", "gene_name": "Rpp25l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQYRRAGSVELPASSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSTRHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPTSPDTGLDPLTVRRHVPAVWVLLSRDPLDPSECGYQPPGAPPGLGSIPSPSCGPRPRRRARDTRS", "length": 163 }, "evidence": [ { "id": "Q2KIR4", "url": "https://omabrowser.org/oma/group/Q2KIR4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ], "pmid": "" }, { "name": "ribonuclease MRP complex", "id": "GO:0000172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000172", "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA 5'-leader removal", "id": "GO:0001682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001682", "evidence": [ { "database": "UniProtKB", "id": "Q2KIR4", "url": "https://www.uniprot.org/uniprotkb/Q2KIR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIR4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIR4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIR4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 145 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIS3-1", "uniprot_ac": "Q2KIS3", "uniprot_id": "UBL7_BOVIN", "mass": { "chemical_mass": 40380.0, "monoisotopic_mass": 40380.0 }, "refseq": {}, "gene_names": [ { "name": "UBL7", "type": "recommended", "evidence": [ { "id": "Q2KIS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein 7", "type": "recommended", "evidence": [ { "id": "Q2KIS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3#function" }, { "database": "UniProtKB", "id": "Q96S82", "url": "https://www.uniprot.org/uniprotkb/Q96S82#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBL7", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3", "locus": { "chromosome": "21", "start_pos": 34223394, "end_pos": 34209831, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000010", "url": "https://www.ensembl.org/id/ENSBTAG00000000010" } ] } } ], "crossref": [ { "id": "Q2KIS3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01815", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01815", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14326", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14326", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q2KIS3", "url": "https://www.orthodb.org/?gene=Q2KIS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10677", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10677", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10677:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10677:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIS3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSDWHLAVKLADQPLAPKSILRLPETELGEYSLGGYSISFLKQLIAGKLQESVPDPELIDLIYCGRKLKDDQTLDFYGIQPGSTVHVLRKSWPEPDQKPEPVDKVAALREFRVLHTALHSSSSYREAVFKMLSNKESLDQIIVATPGLSSDPIALGVLQDKDLFSVFADPNMLDTLVPAHPALVNAIVLVLHSVAGSTPMPGADSSSRGMPSSAYRDMPGGFLFEGLSDDEDDFHPSARSTPSSSTPSSRPASLGYSGAAGPRPITQSELATALALASTPESSSHTPTPGTQGQSSGTSPMSSSVQSGTPITNDLFSQALQHALQASGQPSLQSQWQPQLQQLRDMGIQDDELSLRALQATGGDIQAALELIFAGGAP", "length": 380, "header": "sp|Q2KIS3-1|UBL7_BOVIN Isoform 1 of Ubiquitin-like protein 7 OS=Bos taurus OX=9913 GN=UBL7 PE=2 SV=1 CANONICAL=Q2KIS3-1" }, "isoforms": [ { "isoform_ac": "Q2KIS3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3/entry#Q2KIS3-1", "sequence": { "sequence": "MSLSDWHLAVKLADQPLAPKSILRLPETELGEYSLGGYSISFLKQLIAGKLQESVPDPELIDLIYCGRKLKDDQTLDFYGIQPGSTVHVLRKSWPEPDQKPEPVDKVAALREFRVLHTALHSSSSYREAVFKMLSNKESLDQIIVATPGLSSDPIALGVLQDKDLFSVFADPNMLDTLVPAHPALVNAIVLVLHSVAGSTPMPGADSSSRGMPSSAYRDMPGGFLFEGLSDDEDDFHPSARSTPSSSTPSSRPASLGYSGAAGPRPITQSELATALALASTPESSSHTPTPGTQGQSSGTSPMSSSVQSGTPITNDLFSQALQHALQASGQPSLQSQWQPQLQQLRDMGIQDDELSLRALQATGGDIQAALELIFAGGAP", "length": 380, "header": "sp|Q2KIS3-1|UBL7_BOVIN Isoform 1 of Ubiquitin-like protein 7 OS=Bos taurus OX=9913 GN=UBL7 PE=2 SV=1 CANONICAL=Q2KIS3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 243, "start_aa": "Thr", "end_pos": 243, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr243", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 248, "start_aa": "Thr", "end_pos": 248, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr248", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 290, "start_aa": "Thr", "end_pos": 290, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr290", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 230, "end_pos": 230, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "site_lbl": "Ser230" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "polyubiquitin modification-dependent protein binding", "id": "GO:0031593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031593", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS3", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIS3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" }, { "id": "PRU00212", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00212" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000255", "start_pos": 333, "end_pos": 377, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KIS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS3" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 98, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 243, 248, 290 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 230 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIS6-1", "uniprot_ac": "Q2KIS6", "uniprot_id": "DAAF8_BOVIN", "mass": { "chemical_mass": 38831.0, "monoisotopic_mass": 38831.0 }, "refseq": {}, "gene_names": [ { "name": "DNAAF8", "type": "recommended", "evidence": [ { "id": "Q2KIS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ] }, { "name": "DAAP1", "type": "synonym", "evidence": [ { "id": "Q2KIS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ] } ], "protein_names": [ { "name": "Dynein axonemal assembly factor 8", "type": "recommended", "evidence": [ { "id": "Q2KIS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6/entry#names_and_taxonomy" } ] }, { "name": "Dynein axonemal-associated protein 1", "type": "synonym", "evidence": [ { "id": "Q2KIS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6/entry#names_and_taxonomy" } ] }, { "name": "Uncharacterized protein C16orf71 homolog", "type": "synonym", "evidence": [ { "id": "Q2KIS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6#function" }, { "database": "UniProtKB", "id": "A0A1L8EYB2", "url": "https://www.uniprot.org/uniprotkb/A0A1L8EYB2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAAF8", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6", "locus": {} } ], "crossref": [ { "id": "Q2KIS6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "618674", "url": "https://www.ncbi.nlm.nih.gov/gene/618674", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618674", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618674", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIS6", "url": "https://www.orthodb.org/?gene=Q2KIS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35977:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35977:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIS6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPDEDGRPSLPNPWDAILEAVKHQLPSLDSDSSASDCEDEELFIFQRNQTVLIPDLSEELADDPAGAWVTSSGSPPGLAAVPVESAMEPWGEWNAWPRPKESAPLEGRAPSKSSSLLRMSAETPPRQDDDAGGTLNTSASQSPRQGPQGEATRSPQEAGLQTEPLGAASQAQEGSDAASRKALRRERRKMIEKDILHKVTWDGRNPACPDASRGKEKACDAVEVPSEGPPGCLPVLSLQELEEWDLDQVLLSLTGREEDRGDGAPGAAWWAAGRLQGQDHTEPSTQDRLMERLSLLCARQSRETCRAQPGYGTARERVGSSSSSGHLGRRPLGLSCPPARVLSVRRLRPLEIRPGPALG", "length": 361, "header": "sp|Q2KIS6-1|DAAF8_BOVIN Isoform 1 of Dynein axonemal assembly factor 8 OS=Bos taurus OX=9913 GN=DNAAF8 PE=2 SV=1 CANONICAL=Q2KIS6-1" }, "isoforms": [ { "isoform_ac": "Q2KIS6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6/entry#Q2KIS6-1", "sequence": { "sequence": "MASPDEDGRPSLPNPWDAILEAVKHQLPSLDSDSSASDCEDEELFIFQRNQTVLIPDLSEELADDPAGAWVTSSGSPPGLAAVPVESAMEPWGEWNAWPRPKESAPLEGRAPSKSSSLLRMSAETPPRQDDDAGGTLNTSASQSPRQGPQGEATRSPQEAGLQTEPLGAASQAQEGSDAASRKALRRERRKMIEKDILHKVTWDGRNPACPDASRGKEKACDAVEVPSEGPPGCLPVLSLQELEEWDLDQVLLSLTGREEDRGDGAPGAAWWAAGRLQGQDHTEPSTQDRLMERLSLLCARQSRETCRAQPGYGTARERVGSSSSSGHLGRRPLGLSCPPARVLSVRRLRPLEIRPGPALG", "length": 361, "header": "sp|Q2KIS6-1|DAAF8_BOVIN Isoform 1 of Dynein axonemal assembly factor 8 OS=Bos taurus OX=9913 GN=DNAAF8 PE=2 SV=1 CANONICAL=Q2KIS6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "site_lbl": "Ser142" }, { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "site_lbl": "Ser144" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618674", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618674", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "pmid": "" }, { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS6", "url": "https://www.uniprot.org/uniprotkb/Q2KIS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIS6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIS6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIS6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 142, 144 ], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIS9-1", "uniprot_ac": "Q2KIS9", "uniprot_id": "TSN8_BOVIN", "mass": { "chemical_mass": 26208.0, "monoisotopic_mass": 26208.0 }, "refseq": { "ac": "NP_001073097", "name": "tetraspanin-8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073097" }, "gene_names": [ { "name": "TSPAN8", "type": "recommended", "evidence": [ { "id": "Q2KIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9" } ] }, { "name": "TSPAN-8", "type": "synonym", "evidence": [ { "id": "NP_001073097", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073097" } ] }, { "name": "TSPAN8", "type": "synonym", "evidence": [ { "id": "NP_001073097", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073097" } ] } ], "protein_names": [ { "name": "Tetraspanin-8", "type": "recommended", "evidence": [ { "id": "Q2KIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9/entry#names_and_taxonomy" } ] }, { "name": "Tspan-8", "type": "synonym", "evidence": [ { "id": "Q2KIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-8", "type": "synonym", "evidence": [ { "id": "NP_001073097", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073097" } ] } ], "function": [ { "annotation": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS9", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9#function" }, { "database": "UniProtKB", "id": "P19075", "url": "https://www.uniprot.org/uniprotkb/P19075#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIS9", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN8", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9", "locus": { "chromosome": "5", "start_pos": 809196, "end_pos": 875163, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019425", "url": "https://www.ensembl.org/id/ENSBTAG00000019425" } ] } } ], "crossref": [ { "id": "Q2KIS9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "617508", "url": "https://www.ncbi.nlm.nih.gov/gene/617508", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617508", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617508", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIS9", "url": "https://www.orthodb.org/?gene=Q2KIS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073097", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIS9", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIS9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVLALAFGLAAIEVLGLIFSIVLYCQMRKK", "length": 238, "header": "sp|Q2KIS9-1|TSN8_BOVIN Isoform 1 of Tetraspanin-8 OS=Bos taurus OX=9913 GN=TSPAN8 PE=2 SV=1 CANONICAL=Q2KIS9-1" }, "isoforms": [ { "isoform_ac": "Q2KIS9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9/entry#Q2KIS9-1", "sequence": { "sequence": "MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVLALAFGLAAIEVLGLIFSIVLYCQMRKK", "length": 238, "header": "sp|Q2KIS9-1|TSN8_BOVIN Isoform 1 of Tetraspanin-8 OS=Bos taurus OX=9913 GN=TSPAN8 PE=2 SV=1 CANONICAL=Q2KIS9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 118, "start_aa": "Asn", "end_pos": 118, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn118", "evidence": [ { "id": "Q2KIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617508", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617508", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2KIS9", "url": "https://www.uniprot.org/uniprotkb/Q2KIS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 238, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 118 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIT0-1", "uniprot_ac": "Q2KIT0", "uniprot_id": "HP20_BOVIN", "mass": { "chemical_mass": 20646.0, "monoisotopic_mass": 20646.0 }, "refseq": { "ac": "NP_001040049", "name": "protein HP-20 homolog precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040049" }, "gene_names": [ { "name": "HP-20", "type": "synonym", "evidence": [ { "id": "NP_001040049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040049" } ] }, { "name": "MGC137014", "type": "synonym", "evidence": [ { "id": "NP_001040049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040049" } ] } ], "protein_names": [ { "name": "Protein HP-20 homolog", "type": "recommended", "evidence": [ { "id": "Q2KIT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0/entry#names_and_taxonomy" } ] }, { "name": "protein HP-20 homolog precursor", "type": "synonym", "evidence": [ { "id": "NP_001040049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040049" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIT0", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0", "locus": {} } ], "crossref": [ { "id": "Q2KIT0", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026666", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026666", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616715", "url": "https://www.ncbi.nlm.nih.gov/gene/616715", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616715", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616715", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DVELQHC", "url": "https://omabrowser.org/oma/group/DVELQHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIT0", "url": "https://www.orthodb.org/?gene=Q2KIT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040049", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIT0", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIT0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLRILVSIILMTNAVLEKGGCTGPPGPPGHPGPPGIRGPPGIRGIPGLPGPPGTPGPSVKCPCHRQSAFTVKLSGQLPSPSKPVPFTEVLYNAQRDLQEDTGVFTCRVPGNYHFLFDVDLHHCKVTVQLMRDKSSVLEKHQVSTKEPRSLSGMLTLPLHVGEKVWLEAKVETEKPEQARVTIYFSGFLT", "length": 191, "header": "sp|Q2KIT0-1|HP20_BOVIN Isoform 1 of Protein HP-20 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KIT0-1" }, "isoforms": [ { "isoform_ac": "Q2KIT0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0/entry#Q2KIT0-1", "sequence": { "sequence": "MADLRILVSIILMTNAVLEKGGCTGPPGPPGHPGPPGIRGPPGIRGIPGLPGPPGTPGPSVKCPCHRQSAFTVKLSGQLPSPSKPVPFTEVLYNAQRDLQEDTGVFTCRVPGNYHFLFDVDLHHCKVTVQLMRDKSSVLEKHQVSTKEPRSLSGMLTLPLHVGEKVWLEAKVETEKPEQARVTIYFSGFLT", "length": 191, "header": "sp|Q2KIT0-1|HP20_BOVIN Isoform 1 of Protein HP-20 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KIT0-1" }, "locus": { "chromosome": "5", "start_pos": 71732251, "end_pos": 71727070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105040.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105040.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 56, "start_aa": "Thr", "end_pos": 56, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr56", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616715", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616715", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1APX5-1", "protein_name": "C1q domain-containing protein", "gene_name": "LOC110258309", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGIWILASIILAAVLEKGGCVGPPGPRGPPGPPGLMGFPGFRGPPGLPGLPGYPGPNTKCPCKRESAFTVKLSGKLPSPSKPVNFTEVLYNAQKDFGEDTGVFTCELPGNYHFVFDVELRHCKVIIWLMKDKSPVLEKHQVSTQEIRNLSGMLTLPLSKGDKVWLEAEVETKDPEQALAIIYFSGFLI", "length": 189 }, "evidence": [ { "id": "Q2KIT0", "url": "https://omabrowser.org/oma/group/Q2KIT0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT0", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIT0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 191, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIT0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIT0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT0" }, { "id": "PRU00368", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00368" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000255", "start_pos": 64, "end_pos": 191, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 56 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIT4-1", "uniprot_ac": "Q2KIT4", "uniprot_id": "DNJB4_BOVIN", "mass": { "chemical_mass": 37851.0, "monoisotopic_mass": 37851.0 }, "refseq": { "ac": "NP_001039968", "name": "dnaJ homolog subfamily B member 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039968" }, "gene_names": [ { "name": "DNAJB4", "type": "recommended", "evidence": [ { "id": "Q2KIT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ] }, { "name": "DNAJB4", "type": "synonym", "evidence": [ { "id": "NP_001039968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039968" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily B member 4", "type": "recommended", "evidence": [ { "id": "Q2KIT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily B, member 4", "type": "synonym", "evidence": [ { "id": "NP_001039968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039968" } ] }, { "name": "dnaJ homolog subfamily B member 4", "type": "synonym", "evidence": [ { "id": "NP_001039968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039968" } ] } ], "function": [ { "annotation": "Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4#function" }, { "database": "UniProtKB", "id": "Q9UDY4", "url": "https://www.uniprot.org/uniprotkb/Q9UDY4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJB4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4", "locus": { "chromosome": "3", "start_pos": 66664318, "end_pos": 66707306, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021752", "url": "https://www.ensembl.org/id/ENSBTAG00000021752" } ] } } ], "crossref": [ { "id": "Q2KIT4", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541274", "url": "https://www.ncbi.nlm.nih.gov/gene/541274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541274", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541274", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPIRKEG", "url": "https://omabrowser.org/oma/group/MPIRKEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIT4", "url": "https://www.orthodb.org/?gene=Q2KIT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24078:SF288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24078:SF288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039968", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIT4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKDYYCILGIEKGASDEDIKKAYRKQALRFHPDKNKSPQAEERFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSDEMEVDGDPFGAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNPDGRSYRTEDKILTIEIKKGWKEGTKITFPREGDETPTSIPADIVFVIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTMDGRTIPMTINDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS", "length": 337, "header": "sp|Q2KIT4-1|DNJB4_BOVIN Isoform 1 of DnaJ homolog subfamily B member 4 OS=Bos taurus OX=9913 GN=DNAJB4 PE=2 SV=1 CANONICAL=Q2KIT4-1" }, "isoforms": [ { "isoform_ac": "Q2KIT4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4/entry#Q2KIT4-1", "sequence": { "sequence": "MGKDYYCILGIEKGASDEDIKKAYRKQALRFHPDKNKSPQAEERFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSDEMEVDGDPFGAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNPDGRSYRTEDKILTIEIKKGWKEGTKITFPREGDETPTSIPADIVFVIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTMDGRTIPMTINDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS", "length": 337, "header": "sp|Q2KIT4-1|DNJB4_BOVIN Isoform 1 of DnaJ homolog subfamily B member 4 OS=Bos taurus OX=9913 GN=DNAJB4 PE=2 SV=1 CANONICAL=Q2KIT4-1" }, "locus": { "chromosome": "3", "start_pos": 66672819, "end_pos": 66664384, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028994.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028994.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028994.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028994.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "site_lbl": "Ser122" }, { "start_pos": 148, "end_pos": 148, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "site_lbl": "Ser148" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541274", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A098KXB5-1", "protein_name": "DnaJ homolog subfamily B member 4 isoform X1", "gene_name": "Dnajb4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKDYYYILGIEKGATDEDIKKAYRKQALRFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDNEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIFSGCTKRMKISRKRLNPDGRSYRSEDKILTIDIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKEHPKFKRDGSNIVYTAKISLREALCGCSINVPTMDGRNIPMSISDIVKPGMRRRIIGYGLPFPKNPDQRGDLLVEFEVSFPDAISSSSKEILRKHLPAS", "length": 337 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8D1UUV8-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member B4", "gene_name": "DNAJB4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKDYYCILGIEKGASDEDIKKAYRKQALRFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEDMEVDGDPFSAFGFNMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNPDGRSYRTEDKILTIEIKKGWKEGTKITFPREGDETPTSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSVNVPTMDGRTIPMSINDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS", "length": 337 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q24133-1", "protein_name": "DnaJ protein homolog 1", "gene_name": "DnaJ-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGKDFYKILGLERKASDDEIKKAYRKLALKYHPDKNKSPQAEERFKEIAEAYEVLSDKKKRDIFDNYGEDGLKGGQPGPDGGGQPGAYTYQFHGDPRATFAQFFGSSDPFGAFFTGGDNMFSGGQGGNTNEIFWNIGGDDMFAFNAQAPSRKRQQDPPIEHDLFVSLEEVDKGCIKKMKISRMATGSNGPYKEEKVLRITVKPGWKAGTKITFPQEGDSAPNKTPADIVFIIRDKPHSLFKREGIDLKYTAQISLKQALCGALVSVPTLQGSRIQVNPNHEIIKPTTTRRINGLGLPVPKEPSRRGDLIVSFDIKFPDTLAPSLQNQLSELLPN", "length": 334 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q5XIP0-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member B4", "gene_name": "Dnajb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKDYYHILGIEKGATDEDIKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGANPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPIIHELKVSLEEIYSGCTKRMKISRKRLNPDGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKEHPKFKRDGSNIVYTAKISLREALCGCSINVPTMDGRNIPMSVTDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFDVSFPDVISAASKEILRKHLPAS", "length": 337 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D832-1", "protein_name": "DnaJ homolog subfamily B member 4", "gene_name": "Dnajb4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKDYYHILGIDKGATDEDVKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPIIHELKVSLEEIYSGCTKRMKISRKRLNPDGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFVIKDKEHPKFKRDGSNIVYTAKISLREALCGCSLNVPTMDGRNLPMSVTDIVKPGMRRRVIGYGLPFPKNPDQRGDLLIEFDVSFPDVISAASKEILRKHLPAS", "length": 337 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UDY4-1", "protein_name": "DnaJ homolog subfamily B member 4", "gene_name": "DNAJB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKDYYCILGIEKGASDEDIKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS", "length": 337 }, "evidence": [ { "id": "Q2KIT4", "url": "https://omabrowser.org/oma/group/Q2KIT4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" }, { "name": "ATPase activator activity", "id": "GO:0001671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001671", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT4", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIT4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 337, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIT4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIT4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT4" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 70, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 122, 148 ], "sequon_annotation_sites": [ { "start_pos": 36, "end_pos": 38 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIT6-1", "uniprot_ac": "Q2KIT6", "uniprot_id": "PNMA2_BOVIN", "mass": { "chemical_mass": 41370.0, "monoisotopic_mass": 41370.0 }, "refseq": { "ac": "NP_001039938", "name": "paraneoplastic antigen Ma2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039938" }, "gene_names": [ { "name": "PNMA2", "type": "recommended", "evidence": [ { "id": "Q2KIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6" } ] }, { "name": "PNMA2", "type": "synonym", "evidence": [ { "id": "NP_001039938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039938" } ] } ], "protein_names": [ { "name": "Paraneoplastic antigen Ma2 homolog", "type": "recommended", "evidence": [ { "id": "Q2KIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6/entry#names_and_taxonomy" } ] }, { "name": "paraneoplastic Ma antigen 2", "type": "synonym", "evidence": [ { "id": "NP_001039938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039938" } ] }, { "name": "paraneoplastic antigen Ma2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039938" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIT6", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNMA2", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6", "locus": { "chromosome": "8", "start_pos": 73748699, "end_pos": 73757238, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037986", "url": "https://www.ensembl.org/id/ENSBTAG00000037986" } ] } } ], "crossref": [ { "id": "Q2KIT6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "540301", "url": "https://www.ncbi.nlm.nih.gov/gene/540301", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540301", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540301", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIT6", "url": "https://www.orthodb.org/?gene=Q2KIT6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23095", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23095:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039938", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIT6", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIT6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALALLEDWCRILSVDDQKSLMVMGIPVDCSEDEIQEVLQEILKPLGRYKLLGKIFRKQENANAVLLELLEDPEVSVIPSKVQGKGGIWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGHQGLSPAAMPCISPELLAHVLGQVIAHPPQPLLPMRYRKLRVFSGSAVPAPEEEPFEVWLEQATEIVKEWPVAEAEKKRWLMESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGNLESRRTSQVKYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRNIADQIRLEQVMAGASLSEVLWCRLRELKDQGRPPSFLQLMKVIREEEEEEATFENENTEEPEGGDGYGHWGNEAND", "length": 364, "header": "sp|Q2KIT6-1|PNMA2_BOVIN Isoform 1 of Paraneoplastic antigen Ma2 homolog OS=Bos taurus OX=9913 GN=PNMA2 PE=2 SV=1 CANONICAL=Q2KIT6-1" }, "isoforms": [ { "isoform_ac": "Q2KIT6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6/entry#Q2KIT6-1", "sequence": { "sequence": "MALALLEDWCRILSVDDQKSLMVMGIPVDCSEDEIQEVLQEILKPLGRYKLLGKIFRKQENANAVLLELLEDPEVSVIPSKVQGKGGIWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGHQGLSPAAMPCISPELLAHVLGQVIAHPPQPLLPMRYRKLRVFSGSAVPAPEEEPFEVWLEQATEIVKEWPVAEAEKKRWLMESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGNLESRRTSQVKYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRNIADQIRLEQVMAGASLSEVLWCRLRELKDQGRPPSFLQLMKVIREEEEEEATFENENTEEPEGGDGYGHWGNEAND", "length": 364, "header": "sp|Q2KIT6-1|PNMA2_BOVIN Isoform 1 of Paraneoplastic antigen Ma2 homolog OS=Bos taurus OX=9913 GN=PNMA2 PE=2 SV=1 CANONICAL=Q2KIT6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540301", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540301", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2KIT6", "url": "https://www.uniprot.org/uniprotkb/Q2KIT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIT6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 364, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIT6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIT6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIU3-1", "uniprot_ac": "Q2KIU3", "uniprot_id": "HP252_BOVIN", "mass": { "chemical_mass": 22911.0, "monoisotopic_mass": 22911.0 }, "refseq": { "ac": "NP_001039544", "name": "protein HP-25 homolog 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039544" }, "gene_names": [ { "name": "MGC137211", "type": "recommended", "evidence": [ { "id": "Q2KIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3" } ] }, { "name": "MGC137211", "type": "synonym", "evidence": [ { "id": "NP_001039544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039544" } ] } ], "protein_names": [ { "name": "Protein HP-25 homolog 2", "type": "recommended", "evidence": [ { "id": "Q2KIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3/entry#names_and_taxonomy" } ] }, { "name": "HP-27", "type": "synonym", "evidence": [ { "id": "NP_001039544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039544" } ] }, { "name": "protein HP-25 homolog 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039544" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIU3", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3", "locus": {} } ], "crossref": [ { "id": "Q2KIU3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018556", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018556", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511239", "url": "https://www.ncbi.nlm.nih.gov/gene/511239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1870978", "url": "https://www.iedb.org/epitope/1870978", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511239", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511239", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGYNLEA", "url": "https://omabrowser.org/oma/group/FGYNLEA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIU3", "url": "https://www.orthodb.org/?gene=Q2KIU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q2KIU3", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q2KIU3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001039544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S697", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S697", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S697-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S697-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM63", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM63-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY41", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY41-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIU3", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIU3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGRGGQSLSMVCVDVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG", "length": 215, "header": "sp|Q2KIU3-1|HP252_BOVIN Isoform 1 of Protein HP-25 homolog 2 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KIU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S697-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3/entry#A0AAA9S697-1", "sequence": { "sequence": "MPGRGGQSLSMVCVDVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG", "length": 212, "header": "tr|A0AAA9S697-1|A0AAA9S697_BOVIN Computationally mapped isoform of C1q domain-containing protein OS=Bos taurus OX=9913 GN= PE=1 SV=1 CANONICAL=Q2KIU3-1" }, "locus": { "chromosome": "5", "start_pos": 71712209, "end_pos": 71707095, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102547.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102547.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079381.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079381.1" } ] } }, { "isoform_ac": "A0ABI0NM63-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3/entry#A0ABI0NM63-1", "sequence": { "sequence": "KKENVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG", "length": 204, "header": "tr|A0ABI0NM63-1|A0ABI0NM63_BOVIN Computationally mapped isoform of C1q domain-containing protein OS=Bos taurus OX=9913 GN=MGC137211 PE=1 SV=1 CANONICAL=Q2KIU3-1" }, "locus": { "chromosome": "5", "start_pos": 71712209, "end_pos": 71709931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149467.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149467.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106400.1" } ] } }, { "isoform_ac": "A0ABI0NY41-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3/entry#A0ABI0NY41-1", "sequence": { "sequence": "MQETWVPSVGQKDPLEKEIVTHSSTLAWKIPWTEKPDVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG", "length": 237, "header": "tr|A0ABI0NY41-1|A0ABI0NY41_BOVIN Computationally mapped isoform of C1q domain-containing protein OS=Bos taurus OX=9913 GN=MGC137211 PE=1 SV=1 CANONICAL=Q2KIU3-1" }, "locus": { "chromosome": "5", "start_pos": 71712209, "end_pos": 71707999, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150269.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150269.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104812.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104812.1" } ] } }, { "isoform_ac": "Q2KIU3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3/entry#Q2KIU3-1", "sequence": { "sequence": "MPGRGGQSLSMVCVDVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG", "length": 215, "header": "sp|Q2KIU3-1|HP252_BOVIN Isoform 1 of Protein HP-25 homolog 2 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2KIU3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "1870978", "url": "https://www.iedb.org/epitope/1870978" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] } ], "pathway": [ { "id": "bta:511239", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511239", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU3", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIU3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU3" }, { "id": "PRU00368", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00368" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 215, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 152, "end_pos": 154 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIU7-1", "uniprot_ac": "Q2KIU7", "uniprot_id": "RSPH9_BOVIN", "mass": { "chemical_mass": 31294.0, "monoisotopic_mass": 31294.0 }, "refseq": { "ac": "NP_001039732", "name": "radial spoke head protein 9 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" }, "gene_names": [ { "name": "MAD2L1BP", "type": "recommended", "evidence": [ { "id": "Q2KIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ] }, { "name": "RSPH9", "type": "recommended", "evidence": [ { "id": "Q2KIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ] }, { "name": "C23H6orf206", "type": "synonym", "evidence": [ { "id": "NP_001039732", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" } ] }, { "name": "C6orf206", "type": "synonym", "evidence": [ { "id": "NP_001039732", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" } ] }, { "name": "RSPH9", "type": "synonym", "evidence": [ { "id": "NP_001039732", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" } ] } ], "protein_names": [ { "name": "Radial spoke head protein 9 homolog", "type": "recommended", "evidence": [ { "id": "Q2KIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#names_and_taxonomy" } ] }, { "name": "radial spoke head 9 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039732", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" } ] }, { "name": "radial spoke head protein 9 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039732", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732" } ] } ], "function": [ { "annotation": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7#function" }, { "database": "UniProtKB", "id": "Q9D9V4", "url": "https://www.uniprot.org/uniprotkb/Q9D9V4#function" }, { "database": "UniProtKB", "id": "Q5TYW6", "url": "https://www.uniprot.org/uniprotkb/Q5TYW6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSPH9", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7", "locus": { "chromosome": "23", "start_pos": 17177978, "end_pos": 17164825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009549", "url": "https://www.ensembl.org/id/ENSBTAG00000009549" } ] } } ], "crossref": [ { "id": "Q2KIU7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009548", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009548", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000009549", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009549", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523327", "url": "https://www.ncbi.nlm.nih.gov/gene/523327", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR009511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523327", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523327", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TFYHVPN", "url": "https://omabrowser.org/oma/group/TFYHVPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPT8", "url": "https://www.orthodb.org/?gene=A0A3S5ZPT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIU7", "url": "https://www.orthodb.org/?gene=Q2KIU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15681", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15681", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15681:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15681:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22069", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22069", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22069:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22069:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF06581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039732", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPT8", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPT8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T063", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T063", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T063-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T063-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P312", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P312", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P312-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P312-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIU7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAESLLLALELASGSGQGLSPDRRASLLTSLMLVKRDYRFDRVLFWGRILGLVADYYIAQGVSEDQLAPRKTLYSLNCMEWSLLPPATKEMETQTSVVKGRFMGDPSHEYEHTELQKVNEGEKVFEEEVVVQIKEETRLVSVIDQIDKAVAVIPRGALFKTPFGPINVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKAELDPSLDFMDSLEHDIPKGSWSVQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYIYVGTGEKNLDLPFML", "length": 276, "header": "sp|Q2KIU7-1|RSPH9_BOVIN Isoform 1 of Radial spoke head protein 9 homolog OS=Bos taurus OX=9913 GN=RSPH9 PE=1 SV=1 CANONICAL=Q2KIU7-1" }, "isoforms": [ { "isoform_ac": "A0A3S5ZPT8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#A0A3S5ZPT8-1", "sequence": { "sequence": "MDAEKPLPHSRGAPPTSGPAEQEVEARASHEAPRGAYSNRMENGKEVVMAAPEPEVQPPATVPDLEWCEKSEETQDPQIELLETTSTQEPPNPLEPFRPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKPFPQAEDVVKKKPRATAEVSSRKCQQTLAELESVLSHLEGLFARTLVPRVLILLGGNALSPKEFYELDLSRLAPNSMDPSLSTAACLRRLFRAIFLADAFSELQVPPLMGTIVMAQGHRDCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPAIPATTWEDYIWFQAPLTLKGFHE", "length": 322, "header": "tr|A0A3S5ZPT8-1|A0A3S5ZPT8_BOVIN Computationally mapped isoform of MAD2L1 binding protein OS=Bos taurus OX=9913 GN=MAD2L1BP PE=4 SV=2 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17161864, "end_pos": 17157944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012561.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012561.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012561.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012561.4" } ] } }, { "isoform_ac": "A0AAA9SAR3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#A0AAA9SAR3-1", "sequence": { "sequence": "MEDLEWCEKSEETQDPQIELLETTSTQEPPNPLEPFRPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKPFPQAEDVVKKKPRATAEVSSRKCQQTLAELESVLSHLEGLFARTLVPRVLILLGGNALSPKEFYELDLSRLAPNSMDPSLSTAACLRRLFRAIFLADAFSELQVPPLMGTIVMAQGHRDCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPAIPATTWEDYIWFQAPLTLKGFHE", "length": 261, "header": "tr|A0AAA9SAR3-1|A0AAA9SAR3_BOVIN Computationally mapped isoform of MAD2L1 binding protein OS=Bos taurus OX=9913 GN=MAD2L1BP PE=4 SV=1 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17161864, "end_pos": 17155427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101159.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101159.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080995.1" } ] } }, { "isoform_ac": "A0AAA9T063-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#A0AAA9T063-1", "sequence": { "sequence": "MFWTWRAEEFRATCPSSLLVPPMPQFLPQWHACLLDLEWCEKSEETQDPQIELLETTSTQEPPNPLEPFRPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKPFPQAEDVVKKKPRATAEVSSRKCQQTLAELESVLSHLEGLFARTLVPRVLILLGGNALSPKEFYELDLSRLAPNSMDPSLSTAACLRRLFRAIFLADAFSELQVPPLMGTIVMAQGHRDCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPAIPATTWEDYIWFQAPLTLKGFHE", "length": 294, "header": "tr|A0AAA9T063-1|A0AAA9T063_BOVIN Computationally mapped isoform of MAD2L1 binding protein OS=Bos taurus OX=9913 GN=MAD2L1BP PE=4 SV=1 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17161864, "end_pos": 17153958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090856.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090856.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089904.1" } ] } }, { "isoform_ac": "A0AAA9T3C0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#A0AAA9T3C0-1", "sequence": { "sequence": "MDADLEWCEKSEETQDPQIELLETTSTQEPPNPLEPFRPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKPFPQAEDVVKKKPRATAEVSSRKCQQTLAELESVLSHLEGLFARTLVPRVLILLGGNALSPKEFYELDLSRLAPNSMDPSLSTAACLRRLFRAIFLADAFSELQVPPLMGTIVMAQGHRDCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPAIPATTWEDYIWFQAPLTLKGFHE", "length": 262, "header": "tr|A0AAA9T3C0-1|A0AAA9T3C0_BOVIN Computationally mapped isoform of MAD2L1 binding protein OS=Bos taurus OX=9913 GN=MAD2L1BP PE=4 SV=1 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17161864, "end_pos": 17157944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110526.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110526.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093288.1" } ] } }, { "isoform_ac": "A0ABI0P312-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#A0ABI0P312-1", "sequence": { "sequence": "MENGKEVVMAAPEPEVQPPATVPDLEWCEKSEETQDPQIELLETTSTQEPPNPLEPFRPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKPFPQAEDVVKKKPRATAEVQIKEETRLVSVIDQIDKAVAVIPRGALFKTPFGPINVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKAELDPSLDFMDSLEHDIPKGSWSVQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYIYVGTGEKNLDLPFML", "length": 271, "header": "tr|A0ABI0P312-1|A0ABI0P312_BOVIN Computationally mapped isoform of Radial spoke head protein 9 homolog OS=Bos taurus OX=9913 GN=MAD2L1BP PE=3 SV=1 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17177915, "end_pos": 17158204, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140878.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140878.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105507.1" } ] } }, { "isoform_ac": "Q2KIU7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7/entry#Q2KIU7-1", "sequence": { "sequence": "MDAESLLLALELASGSGQGLSPDRRASLLTSLMLVKRDYRFDRVLFWGRILGLVADYYIAQGVSEDQLAPRKTLYSLNCMEWSLLPPATKEMETQTSVVKGRFMGDPSHEYEHTELQKVNEGEKVFEEEVVVQIKEETRLVSVIDQIDKAVAVIPRGALFKTPFGPINVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKAELDPSLDFMDSLEHDIPKGSWSVQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYIYVGTGEKNLDLPFML", "length": 276, "header": "sp|Q2KIU7-1|RSPH9_BOVIN Isoform 1 of Radial spoke head protein 9 homolog OS=Bos taurus OX=9913 GN=RSPH9 PE=1 SV=1 CANONICAL=Q2KIU7-1" }, "locus": { "chromosome": "23", "start_pos": 17177915, "end_pos": 17164854, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012563.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012563.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012563.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012563.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523327", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523327", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAI9-1", "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "Rsph9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDADSLLLSLELASGSGQGLSPDRRASLLTSLMLVKRDYRFARVLFWGRILGLVADYYIAQGLSEDQLAPRKTLYSLNCTEWSLLPPATEEMVTQTSVVSGRFMGDPSHEYEHTELQKVSEGDKVFDEEVVVQIKEETRLVSIIDQIDKAVAIVPRGALFKTPFGVTHVNRTFEGLPLSEIKKLSSYFHFREAIDLKNKTLLEKADLEPSLDFLDSLEYDIPRALDCLFPLGSWSIQMERGNALVVLRSLLWPGLTFYHAPRSKNYGYIYVGTGEKNMDLPFML", "length": 284 }, "evidence": [ { "id": "Q2KIU7", "url": "https://omabrowser.org/oma/group/Q2KIU7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RRH7-1", "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "RSPH9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSESLLLSLELASGSGQGLSPDRRASLLTSLTLVKRDYRFDRVLFWGRILGLIADYYIAQGLSEDQLAPRKTLYSLNCMEWSLLPPATEEMVTQTSVVKGRFMGDPSHEYEHTELQKVNEGEKVFEEEVVVQIKEETRLVSIIDQIDKAVAVIPRGALFKTPFGPIHVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKADLDPSLDFMDSLEHDIPKGSWSIQTERGNALVVLRSLLWPGLTFYHAPRTKNCGYIYVGTGEKNMDLPFML", "length": 276 }, "evidence": [ { "id": "Q2KIU7", "url": "https://omabrowser.org/oma/group/Q2KIU7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5TYW6-1", "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "rsph9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSDSLHYSLDLAAANGLTLSSEQRAALQSSLLIVKRNYKFSRVLFWGKILGIKSDYFIAQGVEDDELKNRKSLYSLNCVDWHLLPPATESMIADVALAATGRFTGDPSHEYEHTEIRTEGEGDEATHEEVTVKVIEASRLAAIVSNIDKDVSVVPRGAFIKSPNGKVQTNRSFGGLHPTEAAKLRNYLHFREPVNLRNKSILEMSELNPALDFLDPLSEDILKGSWSLQLDRGGTVCVLRSLLWLGFTFFHVPQTPQHGYIYMGDGLMNLDLPFML", "length": 277 }, "evidence": [ { "id": "Q2KIU7", "url": "https://omabrowser.org/oma/group/Q2KIU7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D9V4-1", "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "Rsph9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDADSLLLSLELASGSGQGLSPDRRASLLTSLMLVKRDYRFARVLFWGRILGLVADYYIAQGLSEDQLAPRKTLYSLNCTEWSLLPPATEEMAMQISVVSGRFMGDPSHEYEHTELQKVNEGEKVFDEEVVVQIKEETRLVSIIDQIDKAVAIIPRGALFKTPFGVTHVNRTFEGLPLSEVRKLSSYFHFREAIDLKNKTLLEKSDLEPSLDFLDSLEYDIPRGSWSIQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYIYVGTGEKNMDLPFML", "length": 276 }, "evidence": [ { "id": "Q2KIU7", "url": "https://omabrowser.org/oma/group/Q2KIU7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H1X1-1", "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "RSPH9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDADSLLLSLELASGSGQGLSPDRRASLLTSLMLVKRDYRYDRVLFWGRILGLVADYYIAQGLSEDQLAPRKTLYSLNCTEWSLLPPATEEMVAQSSVVKGRFMGDPSYEYEHTELQKVNEGEKVFEEEIVVQIKEETRLVSVIDQIDKAVAIIPRGALFKTPFGPTHVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKADLDPSLDFMDSLEHDIPKGSWSIQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYVYVGTGEKNMDLPFML", "length": 276 }, "evidence": [ { "id": "Q2KIU7", "url": "https://omabrowser.org/oma/group/Q2KIU7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cilium movement involved in cell motility", "id": "GO:0060294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060294", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "motile cilium assembly", "id": "GO:0044458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044458", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "deactivation of mitotic spindle assembly checkpoint", "id": "GO:1902426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902426", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "regulation of exit from mitosis", "id": "GO:0007096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007096", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "kinocilium", "id": "GO:0060091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060091", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "radial spoke head", "id": "GO:0001535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001535", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q2KIU7", "url": "https://www.uniprot.org/uniprotkb/Q2KIU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIU7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 276, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIU7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIU7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIV0-1", "uniprot_ac": "Q2KIV0", "uniprot_id": "NOL12_BOVIN", "mass": { "chemical_mass": 24707.0, "monoisotopic_mass": 24707.0 }, "refseq": { "ac": "NP_001040022", "name": "nucleolar protein 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040022" }, "gene_names": [ { "name": "NOL12", "type": "recommended", "evidence": [ { "id": "Q2KIV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ] }, { "name": "NOL12", "type": "synonym", "evidence": [ { "id": "NP_001040022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040022" } ] } ], "protein_names": [ { "name": "Nucleolar protein 12", "type": "recommended", "evidence": [ { "id": "Q2KIV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0/entry#names_and_taxonomy" } ] }, { "name": "nucleolar protein 12", "type": "synonym", "evidence": [ { "id": "NP_001040022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040022" } ] } ], "function": [ { "annotation": "Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAS5#function" }, { "database": "UniProtKB", "id": "ARBA00057078", "url": "https://www.uniprot.org/uniprotkb/ARBA00057078#function" }, { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0#function" }, { "database": "UniProtKB", "id": "Q9UGY1", "url": "https://www.uniprot.org/uniprotkb/Q9UGY1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOL12", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0", "locus": { "chromosome": "5", "start_pos": 109524629, "end_pos": 109519280, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060113", "url": "https://www.ensembl.org/id/ENSBTAG00000060113" } ] } } ], "crossref": [ { "id": "Q2KIV0", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051118", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051118", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615252", "url": "https://www.ncbi.nlm.nih.gov/gene/615252", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615252", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615252", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LHMHSRK", "url": "https://omabrowser.org/oma/group/LHMHSRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIV0", "url": "https://www.orthodb.org/?gene=Q2KIV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14577", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14577", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14577:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14577:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040022", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIV0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRNKKKRDGDDRRQRLILSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQKKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPTPEQGAGSGPEEEVSSMEKPTRALPRKSRDPLLSQRISSLTASLHAHSRKKVKKKRLRRAQDTTKKPPSATRTSKTRRRRLTGKARHSGE", "length": 213, "header": "sp|Q2KIV0-1|NOL12_BOVIN Isoform 1 of Nucleolar protein 12 OS=Bos taurus OX=9913 GN=NOL12 PE=2 SV=1 CANONICAL=Q2KIV0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAS5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0/entry#A0AAA9TAS5-1", "sequence": { "sequence": "MGRNKKKRDGDDRRQRLILSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQKKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPTPEQGAGSGPEEEVSSMEKPTRALPRKSRDPLLSQRVNLRPRPHQHSSHRISSLTASLHAHSRKKVKKKRLRRAQDTTKKPPSATRTSKTRRRRLTGKARHSGE", "length": 227, "header": "tr|A0AAA9TAS5-1|A0AAA9TAS5_BOVIN Computationally mapped isoform of Nucleolar protein 12 OS=Bos taurus OX=9913 GN=NOL12 PE=3 SV=1 CANONICAL=Q2KIV0-1" }, "locus": {} }, { "isoform_ac": "Q2KIV0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0/entry#Q2KIV0-1", "sequence": { "sequence": "MGRNKKKRDGDDRRQRLILSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQKKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPTPEQGAGSGPEEEVSSMEKPTRALPRKSRDPLLSQRISSLTASLHAHSRKKVKKKRLRRAQDTTKKPPSATRTSKTRRRRLTGKARHSGE", "length": 213, "header": "sp|Q2KIV0-1|NOL12_BOVIN Isoform 1 of Nucleolar protein 12 OS=Bos taurus OX=9913 GN=NOL12 PE=2 SV=1 CANONICAL=Q2KIV0-1" }, "locus": { "chromosome": "5", "start_pos": 109523625, "end_pos": 109519316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088819.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088819.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093747.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093747.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615252", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615252", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JHB1-1", "protein_name": "Nucleolar protein 12", "gene_name": "Nol12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSTQGTLPAPPLDVPDQAGWCRPLSTRRFRPAQSCALDHPNPARSMVPAHSQLLVVVDKREYLTGFHKRKVERKKAAIEEIKQRLKQEQKKLREERHQEYLKMLAEREEALEEADELERLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPLPEQGDLDGSQEEVSCMEKPTKALPRKSKDPLLSQRISSLTATLHAHSRKKVKRKHPRRAQDSTKKPPSATRTSKTQRRRRMTGKARHSGE", "length": 247 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LFR6-1", "protein_name": "Nucleolar protein 12", "gene_name": "NOL12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRNKKKKRDGDSRRPRLILSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQKKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEQGAGHGPEEETSSVEKPSRALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQESTKKPPSATRTSKTQRRRLTGKARHSGE", "length": 214 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5D1Z3-1", "protein_name": "Nucleolar protein 12", "gene_name": "Nol12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRNKKKKRDGDDRRPRLILNFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKQEQKKLREERHQEYLKMLAEREEALEEADELERLVTAKTESVQYDHPNHTVTVTTVSDLDLSGARLLGLPLPEQGDQDGSQEEEVSSMEKPTKALPKKSKDPLLSQRISSLTATLHAHSRKKVKRKHPRRAQDSTKKPPSATRTSKTQRRRRMTGKARHNGE", "length": 216 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7ZWE7-1", "protein_name": "Nucleolar protein 12", "gene_name": "nol12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGKSDRLQQGSKGKGGGKRKHGKCVLMFDDKDRQDFLTGFHKRKLERRRAALEEMKSKLKEEQKRLREERHKEYLKMLQERRQALDEADELEEAITATTECVQYDHPNHTVTVTTISDLDLSADRLLEPAQRDGGDGEERERTEALPKQAGNPLLSKKIQSLTASLNSLVKQKKRRKQKRRQEAKQRSHQSDRKSSSSAFVHNNKQKQGKSTKRQRRRQTGRNERSQD", "length": 228 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BG17-1", "protein_name": "Nucleolar protein 12", "gene_name": "Nol12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRNKKKKKRDGDDRRPRLVLNFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKQEQKKLREERHQEYLKMLAEREEALEEADELERLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPLPEQGDQDGSQEEEMSSLEKPTKALPRKSKDPLLSQRISSLTATLHAHSRKKVKRKHPRRAQDSTKKPPSATRTSKTQRRRRMTGKARHNGE", "length": 217 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UGY1-1", "protein_name": "Nucleolar protein 12", "gene_name": "NOL12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE", "length": 213 }, "evidence": [ { "id": "Q2KIV0", "url": "https://omabrowser.org/oma/group/Q2KIV0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV0", "url": "https://www.uniprot.org/uniprotkb/Q2KIV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIV0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 213, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIV0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIV0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIV2-1", "uniprot_ac": "Q2KIV2", "uniprot_id": "TIM9_BOVIN", "mass": { "chemical_mass": 10378.0, "monoisotopic_mass": 10378.0 }, "refseq": { "ac": "NP_001039719", "name": "mitochondrial import inner membrane translocase subunit Tim9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039719" }, "gene_names": [ { "name": "TIMM9", "type": "recommended", "evidence": [ { "id": "Q2KIV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ] }, { "name": "TIMM9", "type": "synonym", "evidence": [ { "id": "NP_001039719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039719" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim9", "type": "recommended", "evidence": [ { "id": "Q2KIV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim9", "type": "synonym", "evidence": [ { "id": "NP_001039719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039719" } ] }, { "name": "translocase of inner mitochondrial membrane 9 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039719" } ] } ], "function": [ { "annotation": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM9", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2", "locus": { "chromosome": "10", "start_pos": 70683493, "end_pos": 70699660, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010503", "url": "https://www.ensembl.org/id/ENSBTAG00000010503" } ] } } ], "crossref": [ { "id": "Q2KIV2", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010503", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010503", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521073", "url": "https://www.ncbi.nlm.nih.gov/gene/521073", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521073", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521073", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDFLRMY", "url": "https://omabrowser.org/oma/group/QDFLRMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIV2", "url": "https://www.orthodb.org/?gene=Q2KIV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13172", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13172", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIV2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEETTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89, "header": "sp|Q2KIV2-1|TIM9_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim9 OS=Bos taurus OX=9913 GN=TIMM9 PE=3 SV=1 CANONICAL=Q2KIV2-1" }, "isoforms": [ { "isoform_ac": "Q2KIV2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2/entry#Q2KIV2-1", "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEETTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89, "header": "sp|Q2KIV2-1|TIM9_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim9 OS=Bos taurus OX=9913 GN=TIMM9 PE=3 SV=1 CANONICAL=Q2KIV2-1" }, "locus": { "chromosome": "10", "start_pos": 70686554, "end_pos": 70683779, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013873.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013873.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013873.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013873.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521073", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521073", "resource": "KEGG Pathway" }, { "id": "R-BTA-1268020", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SSK4-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEENTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IMX4-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "Timm9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNRLTESCFLDCVKDFTTREVKPEEVTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O74700-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM9", "gene_name": "TIM9", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDALNSKEQQEFQKVVEQKQMKDFMRLYSNLVERCFTDCVNDFTTSKLTNKEQTCIMKCSEKFLKHSERVGQRFQEQNAALGQGLGR", "length": 87 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5ZIR8-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "TIMM9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGQISETDQIKQFKEFLGTYNKITENCFMDCIRDFTTREVKPEEITCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLSQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9VYD7-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Tim9a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAKTPENIAIDQLDKDQIKTFSDFLMSYNKLSETCFTDCIRDFTTRDVKDSEEKCSLNCMEKYLKMNQRVSQRFQEFQVIAHENALAMAQKTGKL", "length": 95 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W762-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "timm9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAQVTESDQIKQFKEFLGTYNKLTENCFMDCVKDFTTREVKPEETTCSESCLQKYLKMTQRISMRFQEYHIQQNERWPQKPDY", "length": 84 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9WV97-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Timm9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEEVTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WV98-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Timm9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEEVTCSEHCLQKYLKMTQRISVRFQEYHIQQNEALAAKAGLLGQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9XGX9-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM9", "gene_name": "TIM9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDASMMAGLDGLPEEDKAKMASMIDQLQLRDSLRMYNSLVERCFVDCVDSFTRKSLQKQEETCVMRCAEKFLKHTMRVGMRFAELNQNAPTQD", "length": 93 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9Y5J7-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "TIMM9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEETTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR", "length": 89 }, "evidence": [ { "id": "Q2KIV2", "url": "https://omabrowser.org/oma/group/Q2KIV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial intermembrane space chaperone complex", "id": "GO:0042719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042719", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" }, { "name": "protein transporter activity", "id": "GO:0140318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140318", "evidence": [ { "database": "UniProtKB", "id": "Q2KIV2", "url": "https://www.uniprot.org/uniprotkb/Q2KIV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 89, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIV2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIW0-1", "uniprot_ac": "Q2KIW0", "uniprot_id": "NXT1_BOVIN", "mass": { "chemical_mass": 15832.0, "monoisotopic_mass": 15832.0 }, "refseq": { "ac": "NP_001069273", "name": "NTF2-related export protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069273" }, "gene_names": [ { "name": "NXT1", "type": "recommended", "evidence": [ { "id": "Q2KIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ] }, { "name": "NXT1", "type": "synonym", "evidence": [ { "id": "NP_001069273", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069273" } ] } ], "protein_names": [ { "name": "NTF2-related export protein 1", "type": "recommended", "evidence": [ { "id": "Q2KIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0/entry#names_and_taxonomy" } ] }, { "name": "NTF2-like export factor 1", "type": "synonym", "evidence": [ { "id": "NP_001069273", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069273" } ] }, { "name": "NTF2-related export protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069273", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069273" } ] } ], "function": [ { "annotation": "Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NXT1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0", "locus": { "chromosome": "13", "start_pos": 42022739, "end_pos": 42019420, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004993", "url": "https://www.ensembl.org/id/ENSBTAG00000004993" } ] } } ], "crossref": [ { "id": "Q2KIW0", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00780", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00780", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520351", "url": "https://www.ncbi.nlm.nih.gov/gene/520351", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520351", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520351", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIW0", "url": "https://www.orthodb.org/?gene=Q2KIW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12612", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12612", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02136", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02136", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069273", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIW0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVDFKTYVGQACRAAEEFVNVYYSTMDKRRRLLSRLYMGTATLVWNGNAVSGQESLSEFFEMLPSSEFQINVVDCQPVHDEATPSQTTVLVVICGTVKFEGNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAC", "length": 140, "header": "sp|Q2KIW0-1|NXT1_BOVIN Isoform 1 of NTF2-related export protein 1 OS=Bos taurus OX=9913 GN=NXT1 PE=2 SV=1 CANONICAL=Q2KIW0-1" }, "isoforms": [ { "isoform_ac": "Q2KIW0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0/entry#Q2KIW0-1", "sequence": { "sequence": "MASVDFKTYVGQACRAAEEFVNVYYSTMDKRRRLLSRLYMGTATLVWNGNAVSGQESLSEFFEMLPSSEFQINVVDCQPVHDEATPSQTTVLVVICGTVKFEGNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAC", "length": 140, "header": "sp|Q2KIW0-1|NXT1_BOVIN Isoform 1 of NTF2-related export protein 1 OS=Bos taurus OX=9913 GN=NXT1 PE=2 SV=1 CANONICAL=Q2KIW0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 85, "start_aa": "Thr", "end_pos": 85, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr85", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:520351", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520351", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "pmid": "" }, { "name": "nuclear pore central transport channel", "id": "GO:0044613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044613", "evidence": [ { "database": "UniProtKB", "id": "Q2KIW0", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIW0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW0" }, { "id": "PRU00137", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00137" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000255", "start_pos": 16, "end_pos": 135, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 85 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIX1-1", "uniprot_ac": "Q2KIX1", "uniprot_id": "GA45G_BOVIN", "mass": { "chemical_mass": 17294.0, "monoisotopic_mass": 17294.0 }, "refseq": { "ac": "NP_001039366", "name": "growth arrest and DNA damage-inducible protein GADD45 gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039366" }, "gene_names": [ { "name": "GADD45G", "type": "recommended", "evidence": [ { "id": "Q2KIX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ] }, { "name": "GADD45G", "type": "synonym", "evidence": [ { "id": "NP_001039366", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039366" } ] } ], "protein_names": [ { "name": "Growth arrest and DNA damage-inducible protein GADD45 gamma", "type": "recommended", "evidence": [ { "id": "Q2KIX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1/entry#names_and_taxonomy" } ] }, { "name": "growth arrest and DNA damage-inducible protein GADD45 gamma", "type": "synonym", "evidence": [ { "id": "NP_001039366", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039366" } ] } ], "function": [ { "annotation": "Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1#function" }, { "database": "UniProtKB", "id": "A0A452DI17", "url": "https://www.uniprot.org/uniprotkb/A0A452DI17#function" }, { "database": "UniProtKB", "id": "ARBA00055285", "url": "https://www.uniprot.org/uniprotkb/ARBA00055285#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GADD45G", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1", "locus": { "chromosome": "8", "start_pos": 88508026, "end_pos": 88509997, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003033", "url": "https://www.ensembl.org/id/ENSBTAG00000003033" } ] } } ], "crossref": [ { "id": "Q2KIX1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003033", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003033", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504939", "url": "https://www.ncbi.nlm.nih.gov/gene/504939", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504939", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504939", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI17", "url": "https://www.orthodb.org/?gene=A0A452DI17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIX1", "url": "https://www.orthodb.org/?gene=Q2KIX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039366", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI17", "url": "https://www.uniprot.org/uniprotkb/A0A452DI17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI17-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLEELRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGTGDESGAPVDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPNITLPE", "length": 159, "header": "sp|Q2KIX1-1|GA45G_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 gamma OS=Bos taurus OX=9913 GN=GADD45G PE=2 SV=1 CANONICAL=Q2KIX1-1" }, "isoforms": [ { "isoform_ac": "A0A452DI17-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1/entry#A0A452DI17-1", "sequence": { "sequence": "MKSAGSSLPGNTPTKAADLRHCHPPHPSPRGLLARAAGSRLICIRKPARANGLAGSRQLAAPPGSAYIRAHRGAGAHSQAVGSPGWVVDFPSSLASAPPSVLVDNLLLADRNMTLEELRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGTGDESGAPVDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPNITLPE", "length": 271, "header": "tr|A0A452DI17-1|A0A452DI17_BOVIN Computationally mapped isoform of Growth arrest and DNA damage-inducible protein GADD45 gamma OS=Bos taurus OX=9913 GN=GADD45G PE=3 SV=1 CANONICAL=Q2KIX1-1" }, "locus": { "chromosome": "8", "start_pos": 88509798, "end_pos": 88508521, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003943.4", "url": "https://www.ensembl.org/id/ENSBTAT00000003943.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003943.3", "url": "https://www.ensembl.org/id/ENSBTAP00000003943.3" } ] } }, { "isoform_ac": "Q2KIX1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1/entry#Q2KIX1-1", "sequence": { "sequence": "MTLEELRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGTGDESGAPVDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPNITLPE", "length": 159, "header": "sp|Q2KIX1-1|GA45G_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 gamma OS=Bos taurus OX=9913 GN=GADD45G PE=2 SV=1 CANONICAL=Q2KIX1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504939", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504939", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIX7-1", "uniprot_ac": "Q2KIX7", "uniprot_id": "HP251_BOVIN", "mass": { "chemical_mass": 22556.0, "monoisotopic_mass": 22556.0 }, "refseq": { "ac": "NP_001039545", "name": "protein HP-25 homolog 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039545" }, "gene_names": [ { "name": "LOC511240", "type": "recommended", "evidence": [ { "id": "Q2KIX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7" } ] }, { "name": "HP-25", "type": "synonym", "evidence": [ { "id": "NP_001039545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039545" } ] }, { "name": "LOC511240", "type": "synonym", "evidence": [ { "id": "NP_001039545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039545" } ] } ], "protein_names": [ { "name": "Protein HP-25 homolog 1", "type": "recommended", "evidence": [ { "id": "Q2KIX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7/entry#names_and_taxonomy" } ] }, { "name": "protein HP-25 homolog 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039545" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIX7", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7", "locus": {} } ], "crossref": [ { "id": "Q2KIX7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030683", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030683", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511240", "url": "https://www.ncbi.nlm.nih.gov/gene/511240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511240", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511240", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNIAGFW", "url": "https://omabrowser.org/oma/group/MNIAGFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KIX7", "url": "https://www.orthodb.org/?gene=Q2KIX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039545", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P4P4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4P4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX7", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIX7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGGRRRVGSMNIAGFWILAQFVLLLVANVKSSADSELCGPRGARGPPGLSGLPGPPGYTGPIGMPGLTGRPGLPGLVEKCPPLPQSAFSVKLSGPFPGPSQPIVFQEVLYNHQGHFDPATGVFNCSVPGVYHFGFDIELFQSAVKVGLMRNGIQIRDKRAEAGDSHEQASGSSVLELEKGDRVWLESKLDREESEKGTTHAVFYGFLLNGN", "length": 212, "header": "sp|Q2KIX7-1|HP251_BOVIN Isoform 1 of Protein HP-25 homolog 1 OS=Bos taurus OX=9913 GN= PE=1 SV=1 CANONICAL=Q2KIX7-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P4P4-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7/entry#A0ABI0P4P4-1", "sequence": { "sequence": "MAGGSESMRGFWILAQFVLLLVANVKSSADSELCGPRGARGPPGLSGLPGPPGYTGPIGMPGLTGRPGLPGLVEKCPPLPQSAFSVKLSGPFPGPSQPIVFQEVLYNHQGHFDPATGVFNCSVPGVYHFGFDIELFQSAVKVGLMRNGIQIRDKRAEAGDSHEQASGSSVLELEKGDRVWLESKLDREESEKGTTHAVFYGFLLNGN", "length": 207, "header": "tr|A0ABI0P4P4-1|A0ABI0P4P4_BOVIN Computationally mapped isoform of C1q domain-containing protein OS=Bos taurus OX=9913 GN=LOC511240 PE=1 SV=1 CANONICAL=Q2KIX7-1" }, "locus": { "chromosome": "5", "start_pos": 71702381, "end_pos": 71700263, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152341.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152341.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106399.1" } ] } }, { "isoform_ac": "Q2KIX7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7/entry#Q2KIX7-1", "sequence": { "sequence": "MPGGRRRVGSMNIAGFWILAQFVLLLVANVKSSADSELCGPRGARGPPGLSGLPGPPGYTGPIGMPGLTGRPGLPGLVEKCPPLPQSAFSVKLSGPFPGPSQPIVFQEVLYNHQGHFDPATGVFNCSVPGVYHFGFDIELFQSAVKVGLMRNGIQIRDKRAEAGDSHEQASGSSVLELEKGDRVWLESKLDREESEKGTTHAVFYGFLLNGN", "length": 212, "header": "sp|Q2KIX7-1|HP251_BOVIN Isoform 1 of Protein HP-25 homolog 1 OS=Bos taurus OX=9913 GN= PE=1 SV=1 CANONICAL=Q2KIX7-1" }, "locus": { "chromosome": "5", "start_pos": 71702381, "end_pos": 71699610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149445.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149445.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104394.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104394.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 125, "start_aa": "Asn", "end_pos": 125, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn125", "evidence": [ { "id": "Q2KIX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Strategies for proteomics with incompletely characterized genomes: the proteome of Bos taurus serum.", "journal": "Electrophoresis", "date": "2002", "authors": "Wait Robin, Miller Ingrid, Eberini Ivano, Cairoli Fausto, Veronesi Cristina, Battocchio Massimiliano, Gemeiner Manfred, Gianazza Elisabetta", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX7", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7" } ], "reference": [ { "type": "PubMed", "id": "12373772", "url": "https://glygen.org/publication/PubMed/12373772" } ] } ], "pathway": [ { "id": "bta:511240", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511240", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AFE3-1", "protein_name": "C1q domain-containing protein", "gene_name": "LOC110258312", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGERGRAGSMSIAGFWILALFVPLLVANVQSSADSEPCGPHGPQGPPGPQGPPGPRGLTGAQGAPGPGGIPGPPGAIEKCPSPPQSAFSVKLSGPFSGPSQPIVFQEVLYNDQGHFDPATGVFTCTVPGVYHFGFDIILFQNAVNVSLMWNGFQIRDKQVEAKNSHEQASGSSILQLKKGDRVWLEFKLHREEHEKETIQTVFYGFLLNEN", "length": 212 }, "evidence": [ { "id": "Q2KIX7", "url": "https://omabrowser.org/oma/group/Q2KIX7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2KIX7", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIX7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIX7" }, { "id": "PRU00368", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00368" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 212, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "Asn125" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 125 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KIY0-1", "uniprot_ac": "Q2KIY0", "uniprot_id": "COMD6_BOVIN", "mass": { "chemical_mass": 9725.0, "monoisotopic_mass": 9725.0 }, "refseq": { "ac": "NP_001421981", "name": "COMM domain-containing protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421981" }, "gene_names": [ { "name": "COMMD6", "type": "recommended", "evidence": [ { "id": "Q2KIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ] }, { "name": "COMMD6", "type": "synonym", "evidence": [ { "id": "NP_001421981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421981" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 6", "type": "recommended", "evidence": [ { "id": "Q2KIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 6", "type": "synonym", "evidence": [ { "id": "NP_001421981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421981" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Down-regulates activation of NF-kappa-B (By similarity). Inhibits TNF-induced NFKB1 activation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0#function" }, { "database": "UniProtKB", "id": "Q7Z4G1", "url": "https://www.uniprot.org/uniprotkb/Q7Z4G1#function" }, { "database": "UniProtKB", "id": "A0A3Q1LTW1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTW1#function" }, { "database": "UniProtKB", "id": "ARBA00093393", "url": "https://www.uniprot.org/uniprotkb/ARBA00093393#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD6", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0", "locus": {} } ], "crossref": [ { "id": "Q2KIY0", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054578", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054578", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616226", "url": "https://www.ncbi.nlm.nih.gov/gene/616226", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616226", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616226", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTW1", "url": "https://www.orthodb.org/?gene=A0A3Q1LTW1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIY0", "url": "https://www.orthodb.org/?gene=Q2KIY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421981", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTW1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTW1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEESSEPQLDAKSKVTSQLIDFEWKLGMAVSSDSCRSLKYPYVAVMLKVADHSGQVKNKSFEMTIPQFQNFYRQFKEIAAIIETV", "length": 85, "header": "sp|Q2KIY0-1|COMD6_BOVIN Isoform 1 of COMM domain-containing protein 6 OS=Bos taurus OX=9913 GN=COMMD6 PE=3 SV=1 CANONICAL=Q2KIY0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTW1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0/entry#A0A3Q1LTW1-1", "sequence": { "sequence": "MVGALNRAMEESSEPQLDAKSKGSLKLIDFEWKLGMAVSSDSCRSLKYPYVAVMLKVADHSGQVKNKSFEMTIPQFQNFYRQFKEIAAIIETV", "length": 93, "header": "tr|A0A3Q1LTW1-1|A0A3Q1LTW1_BOVIN Computationally mapped isoform of COMM domain-containing protein 6 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=Q2KIY0-1" }, "locus": { "chromosome": "12", "start_pos": 50593094, "end_pos": 50573022, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072353.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072353.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060536.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060536.2" } ] } }, { "isoform_ac": "Q2KIY0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0/entry#Q2KIY0-1", "sequence": { "sequence": "MEESSEPQLDAKSKVTSQLIDFEWKLGMAVSSDSCRSLKYPYVAVMLKVADHSGQVKNKSFEMTIPQFQNFYRQFKEIAAIIETV", "length": 85, "header": "sp|Q2KIY0-1|COMD6_BOVIN Isoform 1 of COMM domain-containing protein 6 OS=Bos taurus OX=9913 GN=COMMD6 PE=3 SV=1 CANONICAL=Q2KIY0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616226", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616226", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY0", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 85, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIY0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY0" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 85, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIY1-1", "uniprot_ac": "Q2KIY1", "uniprot_id": "PXMP2_BOVIN", "mass": { "chemical_mass": 22259.0, "monoisotopic_mass": 22259.0 }, "refseq": { "ac": "NP_001039473", "name": "peroxisomal membrane protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039473" }, "gene_names": [ { "name": "PXMP2", "type": "recommended", "evidence": [ { "id": "Q2KIY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1" } ] }, { "name": "PXMP2", "type": "synonym", "evidence": [ { "id": "NP_001039473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039473" } ] } ], "protein_names": [ { "name": "Peroxisomal membrane protein 2", "type": "recommended", "evidence": [ { "id": "Q2KIY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1/entry#names_and_taxonomy" } ] }, { "name": "peroxisomal membrane protein 2, 22kDa", "type": "synonym", "evidence": [ { "id": "NP_001039473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039473" } ] }, { "name": "peroxisomal membrane protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039473" } ] } ], "function": [ { "annotation": "Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PXMP2", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1", "locus": { "chromosome": "17", "start_pos": 44510299, "end_pos": 44523163, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007510", "url": "https://www.ensembl.org/id/ENSBTAG00000007510" } ] } } ], "crossref": [ { "id": "Q2KIY1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000054166", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054166", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508609", "url": "https://www.ncbi.nlm.nih.gov/gene/508609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MIWPAAN", "url": "https://omabrowser.org/oma/group/MIWPAAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI69", "url": "https://www.orthodb.org/?gene=A0A452DI69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIY1", "url": "https://www.orthodb.org/?gene=Q2KIY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11266:SF80", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11266:SF80", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9603798", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9603798", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039473", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI69", "url": "https://www.uniprot.org/uniprotkb/A0A452DI69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI69-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAASKLRAEAGLGPLPRRALSQYLRLLRLYPVLTKAATSGILSALGNFLAQLIEKKQKKENCSQKLDVSGPLRYAIYGFFFTGPLGHFFYLLMERWIPSEVPLAGIKRLLLDRLLFAPAFLSLFFLVMNFLEGQDTAAFAAKMKSGFWPALRMNWRVWTPVQFININYIPVQFRVLFANLVALFWYAYLASLGK", "length": 196, "header": "sp|Q2KIY1-1|PXMP2_BOVIN Isoform 1 of Peroxisomal membrane protein 2 OS=Bos taurus OX=9913 GN=PXMP2 PE=2 SV=3 CANONICAL=Q2KIY1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJI9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1/entry#A0A3Q1MJI9-1", "sequence": { "sequence": "MTLARSRKRPTAQSGGSSHPAPQSSNRRRRPRGRWPVRESGKSARRCALRNQGSVPGGTAGRGGAGNVRPSPPRALGPAPGKPGVGSVPPGGRGPGKTMAPAASKLRAEAGLGPLPRRALSQYLRLLRLYPVLTKAATSGILSALGNFLAQLIEKKQKKENCSQKLDVSGPLRYAIYGFFFTGPLGHFFYLLMERWIPSEVPLAGIKRLLLDRLLFAPAFLSLFFLVMNFLEGQDTAAFAAKMKSGFWPALRMNWRVWTPVQFININYIPVQVQV", "length": 275, "header": "tr|A0A3Q1MJI9-1|A0A3Q1MJI9_BOVIN Computationally mapped isoform of Peroxisomal membrane protein 2 OS=Bos taurus OX=9913 GN=PXMP2 PE=3 SV=2 CANONICAL=Q2KIY1-1" }, "locus": { "chromosome": "17", "start_pos": 44522964, "end_pos": 44510804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070951.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070951.2" } ] } }, { "isoform_ac": "A0A452DI69-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1/entry#A0A452DI69-1", "sequence": { "sequence": "MTLARSRKRPTAQSGGSSHPAPQSSNRRRRPRGRWPVRESGKSARRCALRNQGSVPGGTAGRGGAGNVRPSPPRALGPAPGKPGVGSVPPGGRGPGKTMAPAASKLRAEAGLGPLPRRALSQYLRLLRLYPVLTKAATSGILSALGNFLAQLIEKKQKKENCSQKLDVSGPLRYAIYGFFFTGPLGHFFYLLMERWIPSEVPLAGIKRLLLDRLLFAPAFLSLFFLVMNFLEGQDTAAFAAKMKSGFWPALRMNWRVWTPVQFININYIPVQFRVLFANLVALFWYAYLASLGK", "length": 294, "header": "tr|A0A452DI69-1|A0A452DI69_BOVIN Computationally mapped isoform of Peroxisomal membrane protein 2 OS=Bos taurus OX=9913 GN=PXMP2 PE=3 SV=1 CANONICAL=Q2KIY1-1" }, "locus": { "chromosome": "17", "start_pos": 44522964, "end_pos": 44512935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009885.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009885.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009885.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009885.3" } ] } }, { "isoform_ac": "A0AAA9SCT0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1/entry#A0AAA9SCT0-1", "sequence": { "sequence": "MTLARSRKRPTAQSGGSSHPAPQSSNRRRRPRGRWPVRESGKSARRCALRNQGSVPGGTAGRGGAGNVRPSPPRALGPAPGKPGVGSVPPGGRGPGKTMAPAASKLRAEAGLGPLPRRALSQYLRLLRLYPVLTKAATSGILSALGNFLAQLIEKKQKKENCSQKLDVSGPLRYAIYGFFFTGPLGHFFYLLMERWIPSEVPLAGIKRLLLDRLLFAPAFLSLFFLVMNFLEGQDTAAFAAKMKSGFWPALRMNWRVWTPVQFININYIPVQVRPASCQRGATGGFKLPYSPAFFPSLGSSQVLDSS", "length": 307, "header": "tr|A0AAA9SCT0-1|A0AAA9SCT0_BOVIN Computationally mapped isoform of Peroxisomal membrane protein 2 OS=Bos taurus OX=9913 GN=PXMP2 PE=3 SV=1 CANONICAL=Q2KIY1-1" }, "locus": { "chromosome": "17", "start_pos": 44522964, "end_pos": 44515349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101069.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101069.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083932.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083932.1" } ] } }, { "isoform_ac": "Q2KIY1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1/entry#Q2KIY1-1", "sequence": { "sequence": "MAPAASKLRAEAGLGPLPRRALSQYLRLLRLYPVLTKAATSGILSALGNFLAQLIEKKQKKENCSQKLDVSGPLRYAIYGFFFTGPLGHFFYLLMERWIPSEVPLAGIKRLLLDRLLFAPAFLSLFFLVMNFLEGQDTAAFAAKMKSGFWPALRMNWRVWTPVQFININYIPVQFRVLFANLVALFWYAYLASLGK", "length": 196, "header": "sp|Q2KIY1-1|PXMP2_BOVIN Isoform 1 of Peroxisomal membrane protein 2 OS=Bos taurus OX=9913 GN=PXMP2 PE=2 SV=3 CANONICAL=Q2KIY1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508609", "resource": "KEGG Pathway" }, { "id": "R-BTA-9603798", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9603798", "resource": "Reactome", "description": "Class I peroxisomal membrane protein import" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIY1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIY1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIY1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIY7-1", "uniprot_ac": "Q2KIY7", "uniprot_id": "BT3L4_BOVIN", "mass": { "chemical_mass": 17315.0, "monoisotopic_mass": 17315.0 }, "refseq": { "ac": "NP_001091575", "name": "transcription factor BTF3 homolog 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091575" }, "gene_names": [ { "name": "BTF3L4", "type": "recommended", "evidence": [ { "id": "Q2KIY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7" } ] }, { "name": "BTF3L4", "type": "synonym", "evidence": [ { "id": "NP_001091575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091575" } ] } ], "protein_names": [ { "name": "Transcription factor BTF3 homolog 4", "type": "recommended", "evidence": [ { "id": "Q2KIY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7/entry#names_and_taxonomy" } ] }, { "name": "Basic transcription factor 3-like 4", "type": "synonym", "evidence": [ { "id": "Q2KIY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7/entry#names_and_taxonomy" } ] }, { "name": "transcription factor BTF3 homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001091575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091575" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIY7", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTF3L4", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7", "locus": { "chromosome": "3", "start_pos": 94255802, "end_pos": 94278872, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011025", "url": "https://www.ensembl.org/id/ENSBTAG00000011025" } ] } } ], "crossref": [ { "id": "Q2KIY7", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011025", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011025", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539753", "url": "https://www.ncbi.nlm.nih.gov/gene/539753", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539753", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539753", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RMQQSVR", "url": "https://omabrowser.org/oma/group/RMQQSVR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIE1", "url": "https://www.orthodb.org/?gene=A0A452DIE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KIY7", "url": "https://www.orthodb.org/?gene=Q2KIY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10351", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10351", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01849", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01849", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001091575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091575", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIE1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIE1-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY7", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKTPKPEDIDEEEDDVPDLVENFDEASKNEAN", "length": 158, "header": "sp|Q2KIY7-1|BT3L4_BOVIN Isoform 1 of Transcription factor BTF3 homolog 4 OS=Bos taurus OX=9913 GN=BTF3L4 PE=2 SV=1 CANONICAL=Q2KIY7-1" }, "isoforms": [ { "isoform_ac": "A0A452DIE1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7/entry#A0A452DIE1-1", "sequence": { "sequence": "MELQGDCKLQNATRPLHLPLFYWEAQSGLAFVVRICDPRIGCSCEREAGQDVSRGSHSRRRGRLRLSLSRLRQPSCCCRVLVLEDPPCFRFTNSMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKTPKPEDIDEEEDDVPDLVENFDEASKNEAN", "length": 252, "header": "tr|A0A452DIE1-1|A0A452DIE1_BOVIN Computationally mapped isoform of Transcription factor BTF3 OS=Bos taurus OX=9913 GN=BTF3L4 PE=1 SV=1 CANONICAL=Q2KIY7-1" }, "locus": { "chromosome": "3", "start_pos": 94277918, "end_pos": 94256213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014646.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014646.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014646.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014646.4" } ] } }, { "isoform_ac": "A0AAA9SAA5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7/entry#A0AAA9SAA5-1", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEECWIAKPQNQKTLMRRRMMFQIS", "length": 78, "header": "tr|A0AAA9SAA5-1|A0AAA9SAA5_BOVIN Computationally mapped isoform of Basic transcription factor 3 like 4 OS=Bos taurus OX=9913 GN=BTF3L4 PE=4 SV=1 CANONICAL=Q2KIY7-1" }, "locus": { "chromosome": "3", "start_pos": 94274446, "end_pos": 94256251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079109.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079109.1" } ] } }, { "isoform_ac": "Q2KIY7-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7/entry#Q2KIY7-1", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKTPKPEDIDEEEDDVPDLVENFDEASKNEAN", "length": 158, "header": "sp|Q2KIY7-1|BT3L4_BOVIN Isoform 1 of Transcription factor BTF3 homolog 4 OS=Bos taurus OX=9913 GN=BTF3L4 PE=2 SV=1 CANONICAL=Q2KIY7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 111, "end_pos": 111, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KIY7", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7" } ], "site_lbl": "Thr111" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539753", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539753", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1WB15-1", "protein_name": "Transcription factor BTF3", "gene_name": "BTF3L4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A3I4-1", "protein_name": "Transcription factor BTF3", "gene_name": "Btf3l4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GVZ1-1", "protein_name": "Transcription factor BTF3", "gene_name": "Btf3l4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q02642-1", "protein_name": "Nascent polypeptide-associated complex subunit beta-1", "gene_name": "EGD1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPIDQEKLAKLQKLSANNKVGGTRRKLNKKAGSSAGANKDDTKLQSQLAKLHAVTIDNVAEANFFKDDGKVMHFNKVGVQVAAQHNTSVFYGLPQEKNLQDLFPGIISQLGPEAIQALSQLAAQMEKHEAKAPADAEKKDEAIPELVEGQTFDADVE", "length": 157 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6PC91-1", "protein_name": "Transcription factor BTF3 homolog 4", "gene_name": "btf3l4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLVVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAETKQLTEMLPGILSQLGADSLTSLRKLAEQFPRQVLDNKAPKAEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96K17-1", "protein_name": "Transcription factor BTF3 homolog 4", "gene_name": "BTF3L4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CAT7-1", "protein_name": "Nascent polypeptide-associated complex subunit beta", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNREKLMKMANTVRTGGKGTVRRKKKAVHKTTTTDDKRLQSTLKRVGVNSIPAIEEVNIFKDDVVIQFINPKVQASIAANTWVVSGTPQTKKLQDILPQIISQLGPDNLDNLKKLAEQFQKQAPGAGDVPATIQEEDDDDDVPDLVVGETFETPATEEAPKAAAS", "length": 165 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CQH7-1", "protein_name": "Transcription factor BTF3 homolog 4", "gene_name": "Btf3l4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN", "length": 158 }, "evidence": [ { "id": "Q2KIY7", "url": "https://omabrowser.org/oma/group/Q2KIY7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 158, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIY7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KIY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIY7" }, { "id": "PRU00507", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00507" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NAC-A/B", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 98, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 111 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KIZ9-1", "uniprot_ac": "Q2KIZ9", "uniprot_id": "CCDB1_BOVIN", "mass": { "chemical_mass": 39664.0, "monoisotopic_mass": 39664.0 }, "refseq": { "ac": "NP_001040069", "name": "cyclin-D1-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040069" }, "gene_names": [ { "name": "CCNDBP1", "type": "recommended", "evidence": [ { "id": "Q2KIZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9" } ] }, { "name": "CCNDBP1", "type": "synonym", "evidence": [ { "id": "NP_001040069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040069" } ] } ], "protein_names": [ { "name": "Cyclin-D1-binding protein 1", "type": "recommended", "evidence": [ { "id": "Q2KIZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9/entry#names_and_taxonomy" } ] }, { "name": "cyclin-D1-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001040069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040069" } ] } ], "function": [ { "annotation": "May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KIZ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KIZ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNDBP1", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9", "locus": { "chromosome": "10", "start_pos": 38403862, "end_pos": 38393597, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013032", "url": "https://www.ensembl.org/id/ENSBTAG00000013032" } ] } } ], "crossref": [ { "id": "Q2KIZ9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KIZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "617512", "url": "https://www.ncbi.nlm.nih.gov/gene/617512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617512", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KIZ9", "url": "https://www.orthodb.org/?gene=Q2KIZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15492", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15492", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15492:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15492:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20936", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20936", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040069", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KIZ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KIZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESAAVSAAPDATLDPPLEQLRHLAGELRQLLPGVRVGEAQETTKEFDREAFWRRFNEAAVTVSREATTLTVAFSRLPLPSPQETQRFCEQVHAAIKAIIGVYYLFPKDQGITLRKLVRSATLDIVDDMAQLVEALYINPAQSSPENLISYNSVWDACQHVPQIPKDNKAAALSVLTKSVDLVKDAHEEMEQAVEECDPYCGLLNDIEEDSSDNHVDEDILGCPNNRDSYWSEEDQELIIPCLALARASKACLKKIRLSVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPVCPLTVRINSAKLASVLKKALEITKASHVTPQPEDSWIPLLINAVDHCMNRIKELTQNEVES", "length": 358, "header": "sp|Q2KIZ9-1|CCDB1_BOVIN Isoform 1 of Cyclin-D1-binding protein 1 OS=Bos taurus OX=9913 GN=CCNDBP1 PE=2 SV=1 CANONICAL=Q2KIZ9-1" }, "isoforms": [ { "isoform_ac": "Q2KIZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9/entry#Q2KIZ9-1", "sequence": { "sequence": "MESAAVSAAPDATLDPPLEQLRHLAGELRQLLPGVRVGEAQETTKEFDREAFWRRFNEAAVTVSREATTLTVAFSRLPLPSPQETQRFCEQVHAAIKAIIGVYYLFPKDQGITLRKLVRSATLDIVDDMAQLVEALYINPAQSSPENLISYNSVWDACQHVPQIPKDNKAAALSVLTKSVDLVKDAHEEMEQAVEECDPYCGLLNDIEEDSSDNHVDEDILGCPNNRDSYWSEEDQELIIPCLALARASKACLKKIRLSVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPVCPLTVRINSAKLASVLKKALEITKASHVTPQPEDSWIPLLINAVDHCMNRIKELTQNEVES", "length": 358, "header": "sp|Q2KIZ9-1|CCDB1_BOVIN Isoform 1 of Cyclin-D1-binding protein 1 OS=Bos taurus OX=9913 GN=CCNDBP1 PE=2 SV=1 CANONICAL=Q2KIZ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617512", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617512", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KIZ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KIZ9", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KIZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KIZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KIZ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ18-1", "uniprot_ac": "Q2KJ18", "uniprot_id": "C2C4A_BOVIN", "mass": { "chemical_mass": 38570.0, "monoisotopic_mass": 38570.0 }, "refseq": { "ac": "NP_001039772", "name": "C2 calcium-dependent domain-containing protein 4A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" }, "gene_names": [ { "name": "C2CD4A", "type": "recommended", "evidence": [ { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" } ] }, { "name": "C2CD4A", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" } ] }, { "name": "C2CD4B", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" } ] }, { "name": "FAM148A", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" }, { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" } ] }, { "name": "NLF1", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" }, { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" } ] } ], "protein_names": [ { "name": "C2 calcium-dependent domain-containing protein 4A", "type": "recommended", "evidence": [ { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18/entry#names_and_taxonomy" } ] }, { "name": "C2 calcium-dependent domain-containing protein 4A-like", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" } ] }, { "name": "C2 calcium-dependent domain-containing protein 4A", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" } ] }, { "name": "Nuclear-localized factor 1", "type": "synonym", "evidence": [ { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM148A", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" }, { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18/entry#names_and_taxonomy" } ] }, { "name": "nuclear-localized factor 1", "type": "synonym", "evidence": [ { "id": "NP_001039772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772" } ] } ], "function": [ { "annotation": "May be involved in inflammatory process. May regulate cell architecture and adhesion (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ18", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ18", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C2CD4A", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18", "locus": {} } ], "crossref": [ { "id": "Q2KJ18", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ18", "database": "AlphaFoldDB", "categories": [] }, { "id": "529849", "url": "https://www.ncbi.nlm.nih.gov/gene/529849", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529849", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529849", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJ18", "url": "https://www.orthodb.org/?gene=Q2KJ18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47226:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47226:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001039772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJ18", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ18-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLGKLRASAASSAPLEPAFSNVLTPNRIPEFFIPPRLPTPYAPESSPPAAALPRRCAAEPDLWLRGADDGAGRTDWDPRSQAALSLPHLPRALTAYGFCALLESPHTRRKESLFLGSPSSAALPPAPRPRAHTYGGGGGDAPLAPGARSPIATPAARGGPSPSLDTLAPPPRCRRLLRAPEGLLRRALRAGRSRGLARARSVSSGDGEDDDEDESRASPGSPTQAPVTSLSPHRDPRPERLEAEGTVTLGRAGGALRLAAEYNRASGRLRVRLLRAEGPAGGAAEPRAPVGCRISFVLKPRGAVVRRSRRAVLEQDLCLDGLSEDEVRRLAVRVKAENRGRGLERGRLLGQGELLLGPLLLL", "length": 364, "header": "sp|Q2KJ18-1|C2C4A_BOVIN Isoform 1 of C2 calcium-dependent domain-containing protein 4A OS=Bos taurus OX=9913 GN=C2CD4A PE=2 SV=1 CANONICAL=Q2KJ18-1" }, "isoforms": [ { "isoform_ac": "Q2KJ18-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18/entry#Q2KJ18-1", "sequence": { "sequence": "MRLLGKLRASAASSAPLEPAFSNVLTPNRIPEFFIPPRLPTPYAPESSPPAAALPRRCAAEPDLWLRGADDGAGRTDWDPRSQAALSLPHLPRALTAYGFCALLESPHTRRKESLFLGSPSSAALPPAPRPRAHTYGGGGGDAPLAPGARSPIATPAARGGPSPSLDTLAPPPRCRRLLRAPEGLLRRALRAGRSRGLARARSVSSGDGEDDDEDESRASPGSPTQAPVTSLSPHRDPRPERLEAEGTVTLGRAGGALRLAAEYNRASGRLRVRLLRAEGPAGGAAEPRAPVGCRISFVLKPRGAVVRRSRRAVLEQDLCLDGLSEDEVRRLAVRVKAENRGRGLERGRLLGQGELLLGPLLLL", "length": 364, "header": "sp|Q2KJ18-1|C2C4A_BOVIN Isoform 1 of C2 calcium-dependent domain-containing protein 4A OS=Bos taurus OX=9913 GN=C2CD4A PE=2 SV=1 CANONICAL=Q2KJ18-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 155, "start_aa": "Thr", "end_pos": 155, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr155", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529849", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529849", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ18", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 364, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ18" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ18" }, { "id": "PRU00041", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000255", "start_pos": 254, "end_pos": 364, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 155 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ24-1", "uniprot_ac": "Q2KJ24", "uniprot_id": "MTM9L_BOVIN", "mass": { "chemical_mass": 60786.0, "monoisotopic_mass": 60786.0 }, "refseq": { "ac": "NP_001039721", "name": "myotubularin-related protein 9-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" }, "gene_names": [ { "name": "MTMR9L", "type": "recommended", "evidence": [ { "id": "Q2KJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ] }, { "name": "LOC521746", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] }, { "name": "MTMR9L", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] }, { "name": "MTMR9", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] } ], "protein_names": [ { "name": "Myotubularin-related protein 9-like", "type": "recommended", "evidence": [ { "id": "Q2KJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24/entry#names_and_taxonomy" } ] }, { "name": "Inactive phosphatidylinositol 3-phosphatase 9-like", "type": "synonym", "evidence": [ { "id": "Q2KJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24/entry#names_and_taxonomy" } ] }, { "name": "inactive phosphatidylinositol 3-phosphatase 9-like", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] }, { "name": "myotubularin-related protein 9-like", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] }, { "name": "myotubularin-related protein 9", "type": "synonym", "evidence": [ { "id": "NP_001039721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721" } ] } ], "function": [ { "annotation": "Probable pseudophosphatase.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTMR9L", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24", "locus": {} } ], "crossref": [ { "id": "Q2KJ24", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014390", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014390", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14536", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14536", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521746", "url": "https://www.ncbi.nlm.nih.gov/gene/521746", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521746", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521746", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVKTKTH", "url": "https://omabrowser.org/oma/group/EVKTKTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ24", "url": "https://www.orthodb.org/?gene=Q2KJ24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10807", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10807:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039721", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ24-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFAEMIRTGQAQAELLRGPEEPPLRGTLCITGHHLLLSPGPQATPDLWLLLLRNVDSIEKRVAGDSGTITLRCKDLRVLQLDIEGVEATLDIARSIEALSSLESVITSFPFFYRPKGLRLGDAWHFHPPECYYKRVARETNAWRLSEANEDFSLCPSYPRAVIVPRAVDDSAVARSARFRQGGRFPVLSYYHAPSGTVLLRAGQPLTGPQKRRCSEDEELLRAVLAGARPGARGFIVDTRSPQAAKQARMTGGGTEAKAAYPGWKRLHRPLERGRPLQESFVRLVEACGDLEQSMDRWLNRLESCRWLSHVKETLSTACLAAQSMEQEGACILVHGAEGTDSTLLITSLAQLILDPLSRTMAGFQELIEREWVQAGHPFQLRCAHSAFSHARPKHEAPTFLLFLDCVWQLGRQFPLSLEFGEGMLLALFDHAYASPFGTFLCNNEKERCLCEVRTRTHSLWSGLSQPKEQRKLRNPLYVPNPLAIWPSAEPQSLRLWQGLFLRGTRPPEPSEVAWEKVWQIVTDQEKTEGSQPTDSASEPGP", "length": 543, "header": "sp|Q2KJ24-1|MTM9L_BOVIN Isoform 1 of Myotubularin-related protein 9-like OS=Bos taurus OX=9913 GN=MTMR9L PE=2 SV=1 CANONICAL=Q2KJ24-1" }, "isoforms": [ { "isoform_ac": "Q2KJ24-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24/entry#Q2KJ24-1", "sequence": { "sequence": "MEFAEMIRTGQAQAELLRGPEEPPLRGTLCITGHHLLLSPGPQATPDLWLLLLRNVDSIEKRVAGDSGTITLRCKDLRVLQLDIEGVEATLDIARSIEALSSLESVITSFPFFYRPKGLRLGDAWHFHPPECYYKRVARETNAWRLSEANEDFSLCPSYPRAVIVPRAVDDSAVARSARFRQGGRFPVLSYYHAPSGTVLLRAGQPLTGPQKRRCSEDEELLRAVLAGARPGARGFIVDTRSPQAAKQARMTGGGTEAKAAYPGWKRLHRPLERGRPLQESFVRLVEACGDLEQSMDRWLNRLESCRWLSHVKETLSTACLAAQSMEQEGACILVHGAEGTDSTLLITSLAQLILDPLSRTMAGFQELIEREWVQAGHPFQLRCAHSAFSHARPKHEAPTFLLFLDCVWQLGRQFPLSLEFGEGMLLALFDHAYASPFGTFLCNNEKERCLCEVRTRTHSLWSGLSQPKEQRKLRNPLYVPNPLAIWPSAEPQSLRLWQGLFLRGTRPPEPSEVAWEKVWQIVTDQEKTEGSQPTDSASEPGP", "length": 543, "header": "sp|Q2KJ24-1|MTM9L_BOVIN Isoform 1 of Myotubularin-related protein 9-like OS=Bos taurus OX=9913 GN=MTMR9L PE=2 SV=1 CANONICAL=Q2KJ24-1" }, "locus": { "chromosome": "2", "start_pos": 121298036, "end_pos": 121291172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019137.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019137.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019137.2", "url": "https://www.ensembl.org/id/ENSBTAP00000019137.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 45, "start_aa": "Thr", "end_pos": 45, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521746", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521746", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BG39-1", "protein_name": "Myotubularin phosphatase domain-containing protein", "gene_name": "LOC106510645", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEFSELIRTGQAQAELLRGSETPPLRGTLCVTGHHLLLSPGAQATPDLWLLLLRSVDSIEKRVEGDSGTITLRCKDLRVLQLEIEGVEATLDIARSIEALSSLESVITSFPFFYRPKSLRLGDAWHFHPPESYYKRVARETNAWRLSEANEDFSLCPSYPRAVIVPRAVNNDALARSARFRQGGRFPVLSYYHAPSGTAVLRSSQPLTGPQKRRCAEDEELLRAVLAGARPGAQGFIVDTRSTQAAKQARMTGGGTESKAAYPGWKRLHRPLERGRPLQESFVRLVEACGDLEQSMDRWLSRLEGCRWLSHVKETLSTACLAAHSMEREGACILVHGAEGTDSTLLVTSLAQIILDPLSRTMAGFQELIEREWIQAGHPFQLRCAHSAFSHARPKHEAPTFLLFLDCVWQLGRQFPLSLEFGEGMLLALFDHSYASPFGTFLCNSEKERCLCEVRTRTHSLWSGLNQPKEQRKLRNPLYVPNPSAIWPSVEPQSLRLWQGLFLRWTRPPEPSEVAWEKVWQIVTDQEKAEGSQPTVSASEPQP", "length": 543 }, "evidence": [ { "id": "Q2KJ24", "url": "https://omabrowser.org/oma/group/Q2KJ24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase binding", "id": "GO:0019903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ24", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 543, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ24-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ24" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ24" }, { "id": "PRU00669", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00669" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myotubularin phosphatase", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 502, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 45 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ25-1", "uniprot_ac": "Q2KJ25", "uniprot_id": "PSD12_BOVIN", "mass": { "chemical_mass": 53053.0, "monoisotopic_mass": 53053.0 }, "refseq": { "ac": "NP_001039893", "name": "26S proteasome non-ATPase regulatory subunit 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893" }, "gene_names": [ { "name": "PSMD12", "type": "recommended", "evidence": [ { "id": "Q2KJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ] }, { "name": "PSMD12", "type": "synonym", "evidence": [ { "id": "NP_001039893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 12", "type": "recommended", "evidence": [ { "id": "Q2KJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome non-ATPase regulatory subunit 12", "type": "synonym", "evidence": [ { "id": "NP_001039893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893" } ] }, { "name": "26S proteasome regulatory subunit RPN5", "type": "synonym", "evidence": [ { "id": "NP_001039893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893" }, { "id": "Q2KJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) 26S subunit, non-ATPase, 12", "type": "synonym", "evidence": [ { "id": "NP_001039893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25#function" }, { "database": "UniProtKB", "id": "O00232", "url": "https://www.uniprot.org/uniprotkb/O00232#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD12", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25", "locus": { "chromosome": "19", "start_pos": 49515377, "end_pos": 49331839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002423", "url": "https://www.ensembl.org/id/ENSBTAG00000002423" } ] } } ], "crossref": [ { "id": "Q2KJ25", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002423", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002423", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538204", "url": "https://www.ncbi.nlm.nih.gov/gene/538204", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q2KJ25", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q2KJ25*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538204", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538204", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AENEMFK", "url": "https://omabrowser.org/oma/group/AENEMFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ25", "url": "https://www.orthodb.org/?gene=Q2KJ25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169091", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1234176", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1236978", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174084", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174154", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174184", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-187577", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871837", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-349425", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-349425", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-350562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5358346", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5607761", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607761", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5607764", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607764", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5610780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5610785", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610785", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5668541", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5676590", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676590", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5687128", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69481", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69601", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854050", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939902", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939902", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8941858", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9762114", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9766229", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9766229", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9929356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9929491", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9932298", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ25-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 456, "header": "sp|Q2KJ25-1|PSD12_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=2 SV=3 CANONICAL=Q2KJ25-1" }, "isoforms": [ { "isoform_ac": "Q2KJ25-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25/entry#Q2KJ25-1", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 456, "header": "sp|Q2KJ25-1|PSD12_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=2 SV=3 CANONICAL=Q2KJ25-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538204", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538204", "resource": "KEGG Pathway" }, { "id": "R-BTA-1169091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "resource": "Reactome", "description": "Activation of NF-kappaB in B cells" }, { "id": "R-BTA-1234176", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "resource": "Reactome", "description": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" }, { "id": "R-BTA-1236978", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "resource": "Reactome", "description": "Cross-presentation of soluble exogenous antigens (endosomes)" }, { "id": "R-BTA-174084", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "resource": "Reactome", "description": "Autodegradation of Cdh1 by Cdh1:APC/C" }, { "id": "R-BTA-174154", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Securin" }, { "id": "R-BTA-174178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-BTA-174184", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-BTA-187577", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "resource": "Reactome", "description": "SCF(Skp2)-mediated degradation of p27/p21" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-202424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "resource": "Reactome", "description": "Downstream TCR signaling" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2871837", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "resource": "Reactome", "description": "FCERI mediated NF-kB activation" }, { "id": "R-BTA-349425", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-349425", "resource": "Reactome", "description": "Autodegradation of the E3 ubiquitin ligase COP1" }, { "id": "R-BTA-350562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-450408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-BTA-4608870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-BTA-4641257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-5358346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-BTA-5607761", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607761", "resource": "Reactome", "description": "Dectin-1 mediated noncanonical NF-kB signaling" }, { "id": "R-BTA-5607764", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607764", "resource": "Reactome", "description": "CLEC7A (Dectin-1) signaling" }, { "id": "R-BTA-5610780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610780", "resource": "Reactome", "description": "Degradation of GLI1 by the proteasome" }, { "id": "R-BTA-5610785", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610785", "resource": "Reactome", "description": "GLI3 is processed to GLI3R by the proteasome" }, { "id": "R-BTA-5632684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-BTA-5668541", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "resource": "Reactome", "description": "TNFR2 non-canonical NF-kB pathway" }, { "id": "R-BTA-5676590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676590", "resource": "Reactome", "description": "NIK-->noncanonical NF-kB signaling" }, { "id": "R-BTA-5687128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "resource": "Reactome", "description": "MAPK6/MAPK4 signaling" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-BTA-69481", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69481", "resource": "Reactome", "description": "G2/M Checkpoints" }, { "id": "R-BTA-69601", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "resource": "Reactome", "description": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A" }, { "id": "R-BTA-75815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75815", "resource": "Reactome", "description": "Ubiquitin-dependent degradation of Cyclin D" }, { "id": "R-BTA-8852276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852276", "resource": "Reactome", "description": "The role of GTSE1 in G2/M progression after G2 checkpoint" }, { "id": "R-BTA-8854050", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "resource": "Reactome", "description": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" }, { "id": "R-BTA-8939236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939236", "resource": "Reactome", "description": "RUNX1 regulates transcription of genes involved in differentiation of HSCs" }, { "id": "R-BTA-8939902", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939902", "resource": "Reactome", "description": "Regulation of RUNX2 expression and activity" }, { "id": "R-BTA-8941858", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "resource": "Reactome", "description": "Regulation of RUNX3 expression and activity" }, { "id": "R-BTA-8948751", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9020702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" }, { "id": "R-BTA-9755511", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-BTA-9762114", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "resource": "Reactome", "description": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" }, { "id": "R-BTA-9766229", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9766229", "resource": "Reactome", "description": "Degradation of CDH1" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" }, { "id": "R-BTA-9929356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "resource": "Reactome", "description": "GSK3B-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9929491", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "resource": "Reactome", "description": "SPOP-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9931269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "resource": "Reactome", "description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" }, { "id": "R-BTA-9932298", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "resource": "Reactome", "description": "Degradation of CRY and PER proteins" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SWJ9-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "PSMD12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 436 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NPQ0-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "PSMD12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEGGAERADGRIVKMEVDYSATVDQRLPECERLAQEGRLQEVIENLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKDWDALNENIILLSKRRSQLKQAVAKMVQQCCTYVEDITDLPVKLRLIDTLRTVTEGKIYVEIERARLTKTLATIKEQNGEVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILSPYDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWTALVEEYGKELREGSLDSPATDVFGCTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEEFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNILNDWSHKLNSLMALVNKTTHLIAKEEMIHNLQ", "length": 456 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O00232-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "PSMD12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 456 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q12250-1", "protein_name": "26S proteasome regulatory subunit RPN5", "gene_name": "RPN5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMHGLQAK", "length": 445 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54UJ0-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "psmD12", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTIGLEPAVSSKTKDKMEQDLSPIADKSCKENRELAKSGKLIEAIENLLITEKQCRQAEDSPSTSKIAAEIIKLCYEAGRLDLVNEKLVLLSKRRGQLRPAIKAIVQESMVYVDQITDMKQKLELIDTLRTISDGKIFVENERARLTKTLSKIKEDEGDIASAAKILQDLQVETYGTMEKREKITFFIDQMRICMNNKDFIRAQLIGNKVNRKTLAEDENQDLKIDYFKQMIRYFSHSANYIEIARCYLSIYDTPSVEKDTPQLLQTLKYICIYVILSASSNEQSDLLNRVYEFKPLTDIQNYKDLLNQFKTLELIRWSTFFELNKPELDSQTVFKTEPNAWEDLRKRVIEHNIRVISTYYQKISTARLAELLDLSLDESEKFVSDLVSNKTIFAKIDRPAGIATFTTTNDPNKVLNAWANNITSLLDLVEKTNHLVQREFMLHKIN", "length": 447 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9D8W5-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "Psmd12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 456 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FIB6-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 12 homolog A", "gene_name": "RPN5A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGDSGKLEATIDRLLNEEKQMRLAENVAGTRKAATEILQLCFDAKDWKLLNEQILNLSKKRGQLKQAVQSMVQQAMQYIDQTPDIETRIELIKTLNNVSAGKIYVEIERARLTKKLAKIKEEQGQIAEAADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDRQDFVRAQILSRKINPRVFDADTKKDKKKPKEGDNMVEEAPADIPTLLELKRIYYELMIRYYSHNNEYIEICRSYKAIYDIPSVKETPEQWIPVLRKICWFLVLAPHDPMQSSLLNATLEDKNLSEIPDFKMLLKQVVTMEVIQWTSLWNKYKDEFEKEKSMIGGSLGDKAGEDLKLRIIEHNILVVSKYYARITLKRLAELLCLSMEEAEKHLSEMVVSKALIAKIDRPSGIVCFQIAKDSNEILNSWAGNLEKLLDLVEKSCHQIHKETMVHKAALRP", "length": 442 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V3Z4-1", "protein_name": "Regulatory particle non-ATPase 5", "gene_name": "Rpn5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDTYLFDGGRITKMEVDYEPACNEKIPLAKELAKKNPDAFHEAIEMMLQLEKQTRLGADMVSCSRVLVAICQICFDASNWNALNEYVSLLVRRRSQLKQAVVKMIQECVTYVDKTPDKETKLKLIDTLRSVTEGKIYVEIERARLTKILADIKEADGDVAGAATVMEELQVETYGSMDKREKVELILEQMRLCLLKEDYVSTQIIAKKISIKFFDDPAQHDLKLKFYYLMIQLNRDTSFLNTSRHYQAIAEPPRKKTGLTPVDSAASTDEQKKKDDDKKKKEEDDKDKKPEVATEAEVEIELTEEQKKELTEKLVCAVLYCVLAPFDNEQSDMMAHLSKNKKLEEVPAYKEILRLFMSKELINFDTFNADFGLVLAENEMFKDSTKHGKKCITELKDRLIEHNIRIIAMYYSRLHLARMSELLNLPTSRCEEYLSKLANTDTIRVKIDRPAGIIYFTQKKSASDILNNWATDVNQLMSLVNKTCHLINKEECVYSVMCAVED", "length": 502 }, "evidence": [ { "id": "Q2KJ25", "url": "https://omabrowser.org/oma/group/Q2KJ25/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ], "pmid": "" }, { "name": "proteasome regulatory particle, lid subcomplex", "id": "GO:0008541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008541", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ25", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 456, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ25" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ25" }, { "id": "PRU01185", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01185" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000255", "start_pos": 242, "end_pos": 420, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 399, "end_pos": 401 }, { "start_pos": 440, "end_pos": 442 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ29-1", "uniprot_ac": "Q2KJ29", "uniprot_id": "PCGF3_BOVIN", "mass": { "chemical_mass": 28081.0, "monoisotopic_mass": 28081.0 }, "refseq": { "ac": "NP_001040032", "name": "polycomb group RING finger protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040032" }, "gene_names": [ { "name": "PCGF3", "type": "recommended", "evidence": [ { "id": "Q2KJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ] }, { "name": "PCGF3", "type": "synonym", "evidence": [ { "id": "NP_001040032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040032" } ] } ], "protein_names": [ { "name": "Polycomb group RING finger protein 3", "type": "recommended", "evidence": [ { "id": "Q2KJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29/entry#names_and_taxonomy" } ] }, { "name": "polycomb group RING finger protein 3", "type": "synonym", "evidence": [ { "id": "NP_001040032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040032" } ] } ], "function": [ { "annotation": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29#function" }, { "database": "UniProtKB", "id": "Q8BTQ0", "url": "https://www.uniprot.org/uniprotkb/Q8BTQ0#function" }, { "database": "UniProtKB", "id": "Q3KNV8", "url": "https://www.uniprot.org/uniprotkb/Q3KNV8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCGF3", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29", "locus": { "chromosome": "6", "start_pos": 117552024, "end_pos": 117594127, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014017", "url": "https://www.ensembl.org/id/ENSBTAG00000014017" } ] } } ], "crossref": [ { "id": "Q2KJ29", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ29", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014017", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014017", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16735", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16735", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17083", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17083", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615967", "url": "https://www.ncbi.nlm.nih.gov/gene/615967", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615967", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615967", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHITCEI", "url": "https://omabrowser.org/oma/group/EHITCEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ29", "url": "https://www.orthodb.org/?gene=Q2KJ29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45893", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45893", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040032", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ29-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGLEVPGDIKGETCSAKQHLDPHRNGETKADDSSNKEAAEEKQEEDGDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 242, "header": "sp|Q2KJ29-1|PCGF3_BOVIN Isoform 1 of Polycomb group RING finger protein 3 OS=Bos taurus OX=9913 GN=PCGF3 PE=2 SV=1 CANONICAL=Q2KJ29-1" }, "isoforms": [ { "isoform_ac": "Q2KJ29-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29/entry#Q2KJ29-1", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGLEVPGDIKGETCSAKQHLDPHRNGETKADDSSNKEAAEEKQEEDGDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 242, "header": "sp|Q2KJ29-1|PCGF3_BOVIN Isoform 1 of Polycomb group RING finger protein 3 OS=Bos taurus OX=9913 GN=PCGF3 PE=2 SV=1 CANONICAL=Q2KJ29-1" }, "locus": { "chromosome": "6", "start_pos": 117576980, "end_pos": 117552710, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018621.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018621.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018621.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018621.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615967", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615967", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T6D0-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "PCGF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGLEVPGDVKGETCSAKQHLDSHRNGETKAEDSSNKEAAEEKQEEDGDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 242 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YG32-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "PCGF3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNPHGRIYTSGHLWPWKSLQYSRYTSQHPCLWIRPCQNTLKPTGDGKRGRYPTPPRLPSPPLALPLPTKDGQGRAGRRRLAERRTPPAAGDRAPPRTRTRRRPPPRQTPKMLTRKIKLWDINAHITCRLCNGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMKKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKTDENSNKETSEEKQEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 352 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7EV63-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "Pcgf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEGELMLFSSSSELGFGSWTQTLSSQHPYFPHAIVLDSPLDAQKKVRHTQKHGHSLLRRKSQIFICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 235 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HEE1-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "Pcgf3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGEACSAKQHLDPRNGETKADDSSNKETAEEKQEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 241 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3KNV8-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "PCGF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 242 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTQ0-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "PcgF3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGEACSAKQHLDPRNGETKADDNSNKETAEEKQEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL", "length": 241 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VV77-1", "protein_name": "Polycomb group RING finger protein 3", "gene_name": "l(3)73Ah", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MERRVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQYISFDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDITQNHEDDNEKVMDAHAESDFHRLDEQVNVCLECISNNFKNLQRRFIRCSSQATITHLKKLVAKKILNGIEKYREIDILCNEELLGKDHTLKFVYVTRWRFRDPPLRLQFRPRVEL", "length": 222 }, "evidence": [ { "id": "Q2KJ29", "url": "https://omabrowser.org/oma/group/Q2KJ29/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "random inactivation of X chromosome", "id": "GO:0060816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060816", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "PcG protein complex", "id": "GO:0031519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031519", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "PRC1 complex", "id": "GO:0035102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035102", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "X chromosome", "id": "GO:0000805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000805", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" }, { "name": "histone H2AK119 ubiquitin ligase activity", "id": "GO:0140862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140862", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ29", "url": "https://www.uniprot.org/uniprotkb/Q2KJ29" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ29-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 242, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ29-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ29" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ69-1", "uniprot_ac": "Q2KJ69", "uniprot_id": "RLIG1_BOVIN", "mass": { "chemical_mass": 37430.0, "monoisotopic_mass": 37430.0 }, "refseq": { "ac": "NP_001070515", "name": "RNA ligase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" }, "gene_names": [ { "name": "C5H12orf29", "type": "recommended", "evidence": [ { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ] }, { "name": "RLIG1", "type": "recommended", "evidence": [ { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ] }, { "name": "C12orf29", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] }, { "name": "C5H12orf29", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] }, { "name": "RLIG1", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] }, { "name": "Rnl", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] } ], "protein_names": [ { "name": "RNA ligase 1", "type": "recommended", "evidence": [ { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#names_and_taxonomy" } ] }, { "name": "6.5.1.3", "type": "synonym", "evidence": [ { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#names_and_taxonomy" } ] }, { "name": "RNA ligase 1", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] }, { "name": "RNA ligase", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" }, { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#names_and_taxonomy" } ] }, { "name": "Rnl", "type": "synonym", "evidence": [ { "id": "Q2KJ69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C12orf29 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515" } ] } ], "function": [ { "annotation": "Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS).", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69#function" }, { "database": "UniProtKB", "id": "Q8N999", "url": "https://www.uniprot.org/uniprotkb/Q8N999#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5I8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5I8#function" }, { "database": "UniProtKB", "id": "ARBA00045151", "url": "https://www.uniprot.org/uniprotkb/ARBA00045151#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RLIG1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69", "locus": { "chromosome": "5", "start_pos": 17840960, "end_pos": 17826844, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018743", "url": "https://www.ensembl.org/id/ENSBTAG00000018743" } ] } } ], "crossref": [ { "id": "Q2KJ69", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018743", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767986", "url": "https://www.ncbi.nlm.nih.gov/gene/767986", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR041211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767986", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767986", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQFMYSA", "url": "https://omabrowser.org/oma/group/KQFMYSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ69", "url": "https://www.orthodb.org/?gene=Q2KJ69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31219:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31219:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17720", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17720", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070515", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5I8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ69-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSTKREHQPFKVLATETLSHKALDADIHNAIPTEKVDGTCCYVTNYKGQPYLWARLDRKPNKLAEKRFKNFLHLKQNSKEFFWNVEEDFKPVPECWIPAKEIEQINGNPIPDENGHIPGWVPVEKNSKQHCWHSSVVDYESEIALVLRHHPDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHSDLLSWFDGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYMNSKPVIINMNLNKYEYAFDAKCLFNHFSKIDNQKFGRLKDIILTV", "length": 325, "header": "sp|Q2KJ69-1|RLIG1_BOVIN Isoform 1 of RNA ligase 1 OS=Bos taurus OX=9913 GN=RLIG1 PE=2 SV=1 CANONICAL=Q2KJ69-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z5I8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#A0AAF6Z5I8-1", "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSTKREHQPFKVLATETLSHKALDADIHNAIPTEKVDGTCCYVTNYKGQPYLWARLDRKPNKLAEKRFKNFLHLKQNSKEFFWNVEEDFKPVPECWIPAKEIEQINGNPIPDENGHIPGWVPVEKNSKQHCWHSSVVDYESEIALVLRHHPDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHSDLLSWFDGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYMNSKPVIINMNLNKYEEKTRFRSVRVCPNNRYQN", "length": 313, "header": "tr|A0AAF6Z5I8-1|A0AAF6Z5I8_BOVIN Computationally mapped isoform of RNA ligase 1 OS=Bos taurus OX=9913 GN=C5H12orf29 PE=4 SV=1 CANONICAL=Q2KJ69-1" }, "locus": { "chromosome": "5", "start_pos": 17840756, "end_pos": 17827001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024959.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024959.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024959.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024959.4" } ] } }, { "isoform_ac": "Q2KJ69-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69/entry#Q2KJ69-1", "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSTKREHQPFKVLATETLSHKALDADIHNAIPTEKVDGTCCYVTNYKGQPYLWARLDRKPNKLAEKRFKNFLHLKQNSKEFFWNVEEDFKPVPECWIPAKEIEQINGNPIPDENGHIPGWVPVEKNSKQHCWHSSVVDYESEIALVLRHHPDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHSDLLSWFDGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYMNSKPVIINMNLNKYEYAFDAKCLFNHFSKIDNQKFGRLKDIILTV", "length": 325, "header": "sp|Q2KJ69-1|RLIG1_BOVIN Isoform 1 of RNA ligase 1 OS=Bos taurus OX=9913 GN=RLIG1 PE=2 SV=1 CANONICAL=Q2KJ69-1" }, "locus": { "chromosome": "5", "start_pos": 17836704, "end_pos": 17827001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142573.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142573.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106017.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:767986", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767986", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RLE3-1", "protein_name": "RNA ligase 1", "gene_name": "C12orf29", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRRGAVQRKVPCLFVTEVKEEPSVKRERQPFKVLATETLSEKALEADIYNAVPTEKVDGTCCYVTTYKGQPYLWARLDRRPNKQAEKRFKRFLYSVEDCKEFIWNVEEDFKPVPDTWIPAKEIEFSNGNPLPDENGHMPGWVPVEKNSKQYCWHSSVVSYETEMALVLKHHADPGLLEIRPVSLSELLEQTLELIGTNINANPYGLGSKKQPIHLLVPHGAFEIKNPPTLKQSDIVSWFEGCSEGKVEGIVWHCRDGCLIKLHRHHLGLCWPLAETYLNSQPVVISFNRNDYDCDFGPKSLFHQFSKLDGQRFDRLKDIKFDD", "length": 324 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2MLK5-1", "protein_name": "RNA ligase 1", "gene_name": "C1H12orf29", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAIATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKDNSKAFLWNMEEDFKPVPECWIPAKEIEQQNGKPVPDENGHIPGWVPVEKNSKQYCWHSSVVNYEFGIALVLRHDPDEPGLLEICAVPLSELLEQTLELIGTNINGNPYGLGSKKSPLHFLIPHGAFPVRNLPTLKHNDLLSWFEDCREGKIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIVNMNLNKYDCAFDNECLFNQFLKKDKQKFDRLKDIMLDV", "length": 325 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SPZ1-1", "protein_name": "RNA ligase 1", "gene_name": "RLIG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSAKREHQPFKVLATETISHKALEADIYSAIPTEKVDGTCCYVTTYKGQPYLWARLDRKPNKLAEKRFKNFLHSKQNSKEFFWNVEEDFKPVPECWIPAKDTEQLNGSPMPDENGHIPGWVPVEKNNKQYCWHSSVVNYEFEIALVLKHHSDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHNDLLSWFEGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYLNSKPVTINMNLNKYEYAFDAKCLFNYFSKIDNQKFSRLKDIVFSV", "length": 325 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5PR55-1", "protein_name": "RNA ligase 1", "gene_name": "", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRLGSVQQKIPCVFLTEVRDEPSRKRDCQQFQVVATENVSPAALASDVHCAAATEKVDGTCCYVTTFNGEPYLWARLDRKPTKQADKRFKKYQYSQKTCKGFVWNVNEDFREVPEFWMAAHRVQHENGHPVPDEHGHIPGWVPVDHTNKQYCWHSSVVNYGTGVALVLKTHGEDEGQLEIVSVPLADLMEQTLELIGTNVNGNPYGLGSKKHPVHVLVPHGVLRIRNPPAVEFQQICSWFQECQEGRVEGIVWHCDDGMLIKIHRHHLGLKWPVADTFLNTRPVVVHVDESDADPCASEKDLFKSFSSVNRQTFSSVRDIQFEP", "length": 325 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AXM9-1", "protein_name": "RNA ligase 1", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKENAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKNSKQYCWHSSVVSYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTNINGNPYGLGSKKYPLHFLTPHGAFQVRNLPTLKHNDLLSWFEGCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLDKYDCAFDHQSLFNKFSKIDKQKFDRLKDITLDI", "length": 325 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHN7-1", "protein_name": "RNA ligase 1", "gene_name": "Rlig1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKESAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKGSKQYCWHSSVVNYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTSINGNPYGLGSKKSPLHFLTPHGAFQVRNLPTLKHNDLLSWFEDCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLNLNNYDCAFDNQSLFNQFSKIDKQKFERLKDIILDV", "length": 327 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N999-1", "protein_name": "RNA ligase 1", "gene_name": "RLIG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRLGSVQRKMPCVFVTEVKEEPSSKREHQPFKVLATETVSHKALDADIYSAIPTEKVDGTCCYVTTYKDQPYLWARLDRKPNKQAEKRFKNFLHSKENPKEFFWNVEEDFKPAPECWIPAKETEQINGNPVPDENGHIPGWVPVEKNNKQYCWHSSVVNYEFEIALVLKHHPDDSGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPSLKHNDLVSWFEDCKEGKIEGIVWHCSDGCLIKVHRHHLGLCWPIPDTYMNSRPVIINMNLNKCDSAFDIKCLFNHFLKIDNQKFVRLKDIIFDV", "length": 325 }, "evidence": [ { "id": "Q2KJ69", "url": "https://omabrowser.org/oma/group/Q2KJ69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ], "pmid": "" }, { "name": "RNA ligase (ATP) activity", "id": "GO:0003972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003972", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to reactive oxygen species", "id": "GO:0000302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000302", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ], "pmid": "" }, { "name": "RNA repair", "id": "GO:0042245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042245", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ69", "url": "https://www.uniprot.org/uniprotkb/Q2KJ69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ69-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 325, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ69-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ69" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.5.1.3", "ec_name": "ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.", "evidence": [] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJ96-1", "uniprot_ac": "Q2KJ96", "uniprot_id": "ARL5A_BOVIN", "mass": { "chemical_mass": 20656.0, "monoisotopic_mass": 20656.0 }, "refseq": { "ac": "NP_001039710", "name": "ADP-ribosylation factor-like protein 5A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039710" }, "gene_names": [ { "name": "ARL5A", "type": "recommended", "evidence": [ { "id": "Q2KJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ] }, { "name": "ARL5A", "type": "synonym", "evidence": [ { "id": "NP_001039710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039710" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 5A", "type": "recommended", "evidence": [ { "id": "Q2KJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like 5A", "type": "synonym", "evidence": [ { "id": "NP_001039710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039710" } ] }, { "name": "ADP-ribosylation factor-like protein 5A", "type": "synonym", "evidence": [ { "id": "NP_001039710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039710" } ] } ], "function": [ { "annotation": "Lacks ADP-ribosylation enhancing activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL5A", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96", "locus": { "chromosome": "2", "start_pos": 44378831, "end_pos": 44355417, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002293", "url": "https://www.ensembl.org/id/ENSBTAG00000002293" } ] } } ], "crossref": [ { "id": "Q2KJ96", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJ96", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002293", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002293", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04153", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04153", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519694", "url": "https://www.ncbi.nlm.nih.gov/gene/519694", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519694", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519694", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ILFARIW", "url": "https://omabrowser.org/oma/group/ILFARIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJ96", "url": "https://www.orthodb.org/?gene=Q2KJ96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039710", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S807", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S807-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJE0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL93", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL93-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJ96-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179, "header": "sp|Q2KJ96-1|ARL5A_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 5A OS=Bos taurus OX=9913 GN=ARL5A PE=2 SV=1 CANONICAL=Q2KJ96-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S807-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#A0AAA9S807-1", "sequence": { "sequence": "MNIQRPSLEISFLHALLSLGIVFRRDVFFFFPEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTELCEGEM", "length": 185, "header": "tr|A0AAA9S807-1|A0AAA9S807_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 5A OS=Bos taurus OX=9913 GN=ARL5A PE=3 SV=1 CANONICAL=Q2KJ96-1" }, "locus": { "chromosome": "2", "start_pos": 44375087, "end_pos": 44365946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094728.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094728.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078280.1" } ] } }, { "isoform_ac": "A0AAA9SD12-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#A0AAA9SD12-1", "sequence": { "sequence": "MSASQAGAAAAAAGPQARPGGPGGWRGVRCPRMGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 211, "header": "tr|A0AAA9SD12-1|A0AAA9SD12_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 5A OS=Bos taurus OX=9913 GN=ARL5A PE=3 SV=2 CANONICAL=Q2KJ96-1" }, "locus": { "chromosome": "2", "start_pos": 44378171, "end_pos": 44355924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125332.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125332.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080204.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080204.2" } ] } }, { "isoform_ac": "A0AAF6YJE0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#A0AAF6YJE0-1", "sequence": { "sequence": "MALWKKGRKNAKASNPEPPVPIRSPLCLTEVPPPTEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 199, "header": "tr|A0AAF6YJE0-1|A0AAF6YJE0_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 5A OS=Bos taurus OX=9913 GN=ARL5A PE=3 SV=1 CANONICAL=Q2KJ96-1" }, "locus": { "chromosome": "2", "start_pos": 44378171, "end_pos": 44355616, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002959.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002959.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002959.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002959.3" } ] } }, { "isoform_ac": "A0ABI0NL93-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#A0ABI0NL93-1", "sequence": { "sequence": "MNSFPQHARGRISRKSHRRVRTATSLTFSEPWPGPQQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 201, "header": "tr|A0ABI0NL93-1|A0ABI0NL93_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 5A OS=Bos taurus OX=9913 GN=ARL5A PE=3 SV=1 CANONICAL=Q2KJ96-1" }, "locus": { "chromosome": "2", "start_pos": 44378171, "end_pos": 44360037, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148628.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148628.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105745.1" } ] } }, { "isoform_ac": "Q2KJ96-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96/entry#Q2KJ96-1", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKGCMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179, "header": "sp|Q2KJ96-1|ARL5A_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 5A OS=Bos taurus OX=9913 GN=ARL5A PE=2 SV=1 CANONICAL=Q2KJ96-1" }, "locus": { "chromosome": "2", "start_pos": 44378171, "end_pos": 44356151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105431.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519694", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519694", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A3R6-1", "protein_name": "ADP ribosylation factor like GTPase 5A", "gene_name": "ARL5A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N3G7-1", "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "Arl5a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVVNNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YCY3-1", "protein_name": "ARF like GTPase 5A", "gene_name": "ARL5A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLLSAIPAPGAELWEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVVNNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTKEELYKMLAHEDLKKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P51646-1", "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "Arl5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVVNNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DHP0-1", "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "arl5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGIIFTKLWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVVNNTHFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYRMLAHEDLKKAGLLIFANKQDVKGCLTVAEISQSLQLTSVKDHQWHIQACCALTGEGLCQGLEWMMSRLRVR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80ZU0-1", "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "Arl5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVVNNTRFLMWDIGGQESLRPSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VSG8-1", "protein_name": "ADP-ribosylation factor-like 5", "gene_name": "Arl5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGLLLSRLWRMFGNEEHKLVMVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEVVWRNIHFLVWDLGGQQSLRAAWSTYYTNTELVIMVIDSTDRERLAVTREELYRMLQHEDLSKASLLVYANKQDLKGSMSAAEISRQLDLTSIKKHQWHIQACCALTGEGLYQGLEWIVQRIKNK", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y689-1", "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "ARL5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR", "length": 179 }, "evidence": [ { "id": "Q2KJ96", "url": "https://omabrowser.org/oma/group/Q2KJ96/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" }, { "name": "protein localization to Golgi membrane", "id": "GO:1903292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903292", "evidence": [ { "database": "UniProtKB", "id": "Q2KJ96", "url": "https://www.uniprot.org/uniprotkb/Q2KJ96" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJ96-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 179, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJ96-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJ96" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9S807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807#function" }, { "id": "A0AAA9S807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 47, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 47, "end_pos": 47, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0#function" }, { "id": "A0AAF6YJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 50, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 50, "end_pos": 50, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0ABI0NL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93#function" }, { "id": "A0ABI0NL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 52, "amino_acid": "Val", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 52, "end_pos": 52, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12#function" }, { "id": "A0AAA9SD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 62, "amino_acid": "Phe", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 62, "end_pos": 62, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807#function" }, { "id": "A0AAA9S807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S807" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 64, "amino_acid": "Met", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 64, "end_pos": 64, "start_aa": "Met", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0#function" }, { "id": "A0AAF6YJE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJE0" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 67, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 67, "end_pos": 67, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0ABI0NL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93#function" }, { "id": "A0ABI0NL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL93" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 69, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 69, "end_pos": 69, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12#function" }, { "id": "A0AAA9SD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD12" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 79, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 79, "end_pos": 79, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJA2-1", "uniprot_ac": "Q2KJA2", "uniprot_id": "ABCF2_BOVIN", "mass": { "chemical_mass": 71475.0, "monoisotopic_mass": 71475.0 }, "refseq": { "ac": "NP_001039601", "name": "ATP-binding cassette sub-family F member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601" }, "gene_names": [ { "name": "ABCF2", "type": "recommended", "evidence": [ { "id": "Q2KJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ] }, { "name": "ABCF2", "type": "synonym", "evidence": [ { "id": "NP_001039601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601" } ] } ], "protein_names": [ { "name": "ATP-binding cassette sub-family F member 2", "type": "recommended", "evidence": [ { "id": "Q2KJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette sub-family F member 2", "type": "synonym", "evidence": [ { "id": "NP_001039601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601" } ] }, { "name": "ATP-binding cassette, sub-family F (GCN20), member 2", "type": "synonym", "evidence": [ { "id": "NP_001039601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601" } ] }, { "name": "ATP-binding cassette, sub-family F, member 2", "type": "synonym", "evidence": [ { "id": "NP_001039601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCF2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2", "locus": { "chromosome": "4", "start_pos": 113788362, "end_pos": 113803182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000607", "url": "https://www.ensembl.org/id/ENSBTAG00000000607" } ] } } ], "crossref": [ { "id": "Q2KJA2", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000607", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000607", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03221", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03221", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513061", "url": "https://www.ncbi.nlm.nih.gov/gene/513061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513061", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYEGTML", "url": "https://omabrowser.org/oma/group/QYEGTML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJA2", "url": "https://www.orthodb.org/?gene=Q2KJA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19211", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19211", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19211:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19211:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12848", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12848", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039601", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJA2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVGEEPQPTRRTHNV", "length": 625, "header": "sp|Q2KJA2-1|ABCF2_BOVIN Isoform 1 of ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=2 SV=1 CANONICAL=Q2KJA2-1" }, "isoforms": [ { "isoform_ac": "Q2KJA2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2/entry#Q2KJA2-1", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVGEEPQPTRRTHNV", "length": 625, "header": "sp|Q2KJA2-1|ABCF2_BOVIN Isoform 1 of ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=2 SV=1 CANONICAL=Q2KJA2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "site_lbl": "Thr220" }, { "start_pos": 514, "end_pos": 514, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "site_lbl": "Ser514" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513061", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513061", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A096MIV5-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "Abcf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAVTEPQVAEEKNETNGRETTGDGEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAVGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV", "length": 627 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7H8T9-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "LOC100760577", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDTVTEPQVAEEKNEEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSEKTPLECVMEVDTERAMLEREAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV", "length": 625 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1QZ64-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "abcf2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARGRTRKPEDGVNGDAEKPEIQENGAAEVNGVDSLAKELDEFELKKTEARAVTGVLASHPNSTDVHISSLSLTFHGQELLSDTSLELNSGRRYGLIGLNGTGKSMLLSAISHREVPIPEHIDIYHLTREMAPSEKTALQCVMEVDEERIKLEKEAERLAHEDSECEKLMELYERLEELDADKASMRASRILHGLGFTTSMQQKKLKDFSGGWRMRVALARALFLKPFMLLLDEPTNHLDLDACVWLEEELSQFKRILVLISHSQDFLNGVCTNIIHLHQRKLKYYTGNYDQYVKTREELEENQMKRFNWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMVASGLTERVVNDKTLSFYFPPCGKIPPPVIMVQNVSFRYSENTPYIYKNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPSDGMIRKHSHVKIGRYHQHLTEQLELDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCFAWLAWQNPHMLFLDEPTNHLDIETIDALAEAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWSRDILAYKEHLKSKIDKQMHDL", "length": 613 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P40024-1", "protein_name": "ABC transporter ATP-binding protein ARB1", "gene_name": "ARB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPPVSASKAKRDAKKAEREAKKAAAGKTIRKLGRKKEAAAEESEVDAAAREIKMMKLQQDKDGLSDRVVTGVLSSLETSRDIKLSSVSLLFHGKVLIQDSGLELNYGRRYGLLGENGCGKSTFLKALATREYPIPEHIDIYLLDEPAEPSELSALDYVVTEAQHELKRIEDLVEKTILEDGPESELLEPLYERMDSLDPDTFESRAAIILIGLGFNKKTILKKTKDMSGGWKMRVALAKALFVKPTLLLLDDPTAHLDLEACVWLEEYLKRFDRTLVLVSHSQDFLNGVCTNMIDMRAQKLTAYGGNYDSYHKTRSELETNQMKQYNKQQEEIQHIKKFIASAGTYANLVKQAKSRQKILDKMEADGLVQPVVPDKVFSFRFPQVERLPPPVLAFDDISFHYESNPSENLYEHLNFGVDMDSRIALVGPNGVGKSTLLKIMTGELTPQSGRVSRHTHVKLGVYSQHSQDQLDLTKSALEFVRDKYSNISQDFQFWRGQLGRYGLTGEGQTVQMATLSEGQRSRVVFALLALEQPNVLLLDEPTNGLDIPTIDSLADAINEFNGGVVVVSHDFRLLDKIAQDIFVVENKTATRWDGSILQYKNKLAKNVVL", "length": 610 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q99LE6-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "Abcf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAVTEPQVAEEKIEEANGRETTGDGEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSEKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV", "length": 628 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FJH6-1", "protein_name": "ABC transporter F family member 1", "gene_name": "ABCF1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVSDASKKKAAQKKAAAAAKRGGKAAAPSKSAATSSNGVDSLSSGVDALQISDRTCTGVLCSHPQSRDIRIESLSVTFHGYDLIVDSMLELNYGRRYGLLGLNGCGKSTLLTAIGRREIPIPDQMDIYHLSHEIEATDMSSLEAVVSCDEERLRLEKEVEILVQQDDGGGERLQSIYERLDAMDAETAEKRAAEILFGLGFDKEMQAKKTKDFSGGWRMRIALARALFIMPTILLLDEPTNHLDLEACVWLEESLKNFDRILVVVSHSQDFLNGVCTNIIHMQSKQLKYYTGNFDQYCQTRSELEENQMKQYRWEQEQISHMKEYIARFGHGSAKLARQAQSKEKTLAKMERGGLTEKVARDSVLVFRFADVGKLPPPVLQFVEVSFGYTPDYLIYKNIDFGVDLDSRVALVGPNGAGKSTLLKLMTGELHPTEGMVRRHNHLKIAQYHQHLAEKLDLELPALLYMMREFPGTEEEKMRAAIGRFGLTGKAQVMPMKNLSDGQRSRVIFAWLAYKQPNMLLLDEPTNHLDIETIDSLAEALNEWDGGLVLVSHDFRLINQVAHEIWVCEKQCITKWNGDIMDFKRHLKAKAGLED", "length": 595 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UG63-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "ABCF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV", "length": 623 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VXR5-1", "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "Dmel\\CG9281", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSAAKKREAQKKKDARNKKIQQIPSTKKANGVPERELTEEEKLCAKLEEEARISAEARSCTGSLAVHPRSRDVKIANFSITFFGSELLQDTMLELNCGRRYGLIGLNGCGKSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSALQCVMEVDEERIKLEKLAEELAMSEEDDAQEQLIDIYERLDDMSADLAEVKAARILHGLGFDKAMQQKQAKDFSGGWRMRIALARALFVKPHLLLLDEPTNHLDLDACVWLEEELKTYKRILVLISHSQDFLNGVCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVSDDKVLNFYFPSCGKVPPPVIMVQNVNFRYNDETPWIYKNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLVPTSGMIRKNSHLRIARYHQHLHELLDLDASPLEYMMRAFPDVKEKEEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPHLLLLDEPTNHLDMETIDALADAINDFDGGMVLVSHDFRLINQVAEEIWVCEKETVTKWKGGILDYKDHLKNKITSENEKKAKAGK", "length": 611 }, "evidence": [ { "id": "Q2KJA2", "url": "https://omabrowser.org/oma/group/Q2KJA2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA2", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 625, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJA2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" }, { "id": "PRU00434", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00434" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter 1", "eco_id": "ECO_0000255", "start_pos": 88, "end_pos": 327, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2KJA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA2" }, { "id": "PRU00434", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00434" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter 2", "eco_id": "ECO_0000255", "start_pos": 398, "end_pos": 615, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 220, 514 ], "sequon_annotation_sites": [ { "start_pos": 402, "end_pos": 404 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 84, "end_pos": 86 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KJA6-1", "uniprot_ac": "Q2KJA6", "uniprot_id": "INT9_BOVIN", "mass": { "chemical_mass": 73837.0, "monoisotopic_mass": 73837.0 }, "refseq": { "ac": "NP_001039828", "name": "integrator complex subunit 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039828" }, "gene_names": [ { "name": "INTS9", "type": "recommended", "evidence": [ { "id": "Q2KJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ] }, { "name": "INTS9", "type": "synonym", "evidence": [ { "id": "NP_001039828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039828" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 9", "type": "recommended", "evidence": [ { "id": "Q2KJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6/entry#names_and_taxonomy" } ] }, { "name": "Int9", "type": "synonym", "evidence": [ { "id": "Q2KJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6/entry#names_and_taxonomy" } ] }, { "name": "int9", "type": "synonym", "evidence": [ { "id": "NP_001039828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039828" } ] }, { "name": "integrator complex subunit 9", "type": "synonym", "evidence": [ { "id": "NP_001039828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039828" } ] } ], "function": [ { "annotation": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6#function" }, { "database": "UniProtKB", "id": "Q9NV88", "url": "https://www.uniprot.org/uniprotkb/Q9NV88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS9", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6", "locus": { "chromosome": "8", "start_pos": 9967280, "end_pos": 9840507, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008845", "url": "https://www.ensembl.org/id/ENSBTAG00000008845" } ] } } ], "crossref": [ { "id": "Q2KJA6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16294", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16294", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533964", "url": "https://www.ncbi.nlm.nih.gov/gene/533964", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533964", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533964", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJA6", "url": "https://www.orthodb.org/?gene=Q2KJA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46094:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46094:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21382", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21382", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039828", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJA6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDSMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSIPFYFISPVANSSLEFSQIFAEWLCHNKQTKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPTPAQSHRMDLMVDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHVLQPPPRPTQPTGGKKRKRASDDIPDCKVLKPLLSGSIPVDQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDDDEVLRVRLRDLVLKFLQKF", "length": 658, "header": "sp|Q2KJA6-1|INT9_BOVIN Isoform 1 of Integrator complex subunit 9 OS=Bos taurus OX=9913 GN=INTS9 PE=2 SV=1 CANONICAL=Q2KJA6-1" }, "isoforms": [ { "isoform_ac": "Q2KJA6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6/entry#Q2KJA6-1", "sequence": { "sequence": "MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDSMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSIPFYFISPVANSSLEFSQIFAEWLCHNKQTKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPTPAQSHRMDLMVDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHVLQPPPRPTQPTGGKKRKRASDDIPDCKVLKPLLSGSIPVDQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDDDEVLRVRLRDLVLKFLQKF", "length": 658, "header": "sp|Q2KJA6-1|INT9_BOVIN Isoform 1 of Integrator complex subunit 9 OS=Bos taurus OX=9913 GN=INTS9 PE=2 SV=1 CANONICAL=Q2KJA6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 479, "start_aa": "Thr", "end_pos": 479, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr479", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:533964", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533964", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "INTAC complex", "id": "GO:0160232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160232", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway", "id": "GO:0090101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090101", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "regulation of cellular response to growth factor stimulus", "id": "GO:0090287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090287", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" }, { "name": "RNA polymerase II transcription initiation surveillance", "id": "GO:0160240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160240", "evidence": [ { "database": "UniProtKB", "id": "Q2KJA6", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 658, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJA6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJA6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 566, "end_pos": 570, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 479, 560 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 334, "end_pos": 336 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJB6-1", "uniprot_ac": "Q2KJB6", "uniprot_id": "VA0D2_BOVIN", "mass": { "chemical_mass": 40497.0, "monoisotopic_mass": 40497.0 }, "refseq": { "ac": "NP_001039566", "name": "V-type proton ATPase subunit d 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" }, "gene_names": [ { "name": "ATP6V0D2", "type": "recommended", "evidence": [ { "id": "Q2KJB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ] }, { "name": "ATP6V0D2", "type": "synonym", "evidence": [ { "id": "NP_001039566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" } ] } ], "protein_names": [ { "name": "V-type proton ATPase subunit d 2", "type": "recommended", "evidence": [ { "id": "Q2KJB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6/entry#names_and_taxonomy" } ] }, { "name": "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2", "type": "synonym", "evidence": [ { "id": "NP_001039566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" } ] }, { "name": "V-ATPase subunit d 2", "type": "synonym", "evidence": [ { "id": "NP_001039566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" }, { "id": "Q2KJB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6/entry#names_and_taxonomy" } ] }, { "name": "V-type proton ATPase subunit d 2", "type": "synonym", "evidence": [ { "id": "NP_001039566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" } ] }, { "name": "Vacuolar proton pump subunit d 2", "type": "synonym", "evidence": [ { "id": "Q2KJB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6/entry#names_and_taxonomy" } ] }, { "name": "vacuolar proton pump subunit d 2", "type": "synonym", "evidence": [ { "id": "NP_001039566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566" } ] } ], "function": [ { "annotation": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6#function" }, { "database": "UniProtKB", "id": "P61420", "url": "https://www.uniprot.org/uniprotkb/P61420#function" }, { "database": "UniProtKB", "id": "Q80SY3", "url": "https://www.uniprot.org/uniprotkb/Q80SY3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LJQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ0#function" }, { "database": "UniProtKB", "id": "PIRNR018497", "url": "https://www.uniprot.org/uniprotkb/PIRNR018497#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATP6V0D2", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6", "locus": { "chromosome": "14", "start_pos": 76530194, "end_pos": 76586295, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021092", "url": "https://www.ensembl.org/id/ENSBTAG00000021092" } ] } } ], "crossref": [ { "id": "Q2KJB6", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021092", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021092", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511839", "url": "https://www.ncbi.nlm.nih.gov/gene/511839", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511839", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511839", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETLFPTC", "url": "https://omabrowser.org/oma/group/ETLFPTC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJQ0", "url": "https://www.orthodb.org/?gene=A0A3Q1LJQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KJB6", "url": "https://www.orthodb.org/?gene=Q2KJB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1222556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1222556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77387", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77387", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-917977", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917977", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983712", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983712", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJB6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLESAELNFNADHGYLEGLVRGCKAGLLTRRDYVNLVQCENLEDLKIHLQTTDYGNFLANQATPLTVSVIDTEMRKKLCREFEYFRNHSLEPLSTFFTYMTCSYMIDNVILLMNGALQNKPVKDVLVKCHPLGHFTEMEAVNIAETPSDLFNAILVETPLAPFFQDCTSENALDELNIEILRNKLYKSYIEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITLNSFGTELSKEDRETLYPTCGKLHPEGLRLLAQAEDFEQMKRVADSYGVYKPLFEAVSDSSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYTKLKEQEMRNIVWIAECISQRQRTKINSYIPIL", "length": 351, "header": "sp|Q2KJB6-1|VA0D2_BOVIN Isoform 1 of V-type proton ATPase subunit d 2 OS=Bos taurus OX=9913 GN=ATP6V0D2 PE=2 SV=1 CANONICAL=Q2KJB6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJQ0-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6/entry#A0A3Q1LJQ0-1", "sequence": { "sequence": "MLESAELNFNADHGYLEGLVRGCKAGLLTRRDYVNLVQCENLEDLKIHLQTTDYGNFLANQATPLTVSVIDTEMRKKLCREFEYFRNHSLEPLSTFFTYMTCSYMIDNVILLMNGALQNKPVKDVLVKCHPLGHFTEMEAVNIAETPSDLFNAILVETPLAPFFQDCTSENALDELNIEILRNKLYKFEADRRAFIITLNSFGTELSKEDRETLYPTCGKLHPEGLRLLAQAEDFEQMKRVADSYGVYKPLFEAVSDSSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYTKLKEQEMRNIVWIAECISQRQRTKINSYIPIL", "length": 325, "header": "tr|A0A3Q1LJQ0-1|A0A3Q1LJQ0_BOVIN Computationally mapped isoform of V-type proton ATPase subunit OS=Bos taurus OX=9913 GN=ATP6V0D2 PE=3 SV=1 CANONICAL=Q2KJB6-1" }, "locus": { "chromosome": "14", "start_pos": 76586146, "end_pos": 76530968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087046.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087046.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059690.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059690.1" } ] } }, { "isoform_ac": "Q2KJB6-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6/entry#Q2KJB6-1", "sequence": { "sequence": "MLESAELNFNADHGYLEGLVRGCKAGLLTRRDYVNLVQCENLEDLKIHLQTTDYGNFLANQATPLTVSVIDTEMRKKLCREFEYFRNHSLEPLSTFFTYMTCSYMIDNVILLMNGALQNKPVKDVLVKCHPLGHFTEMEAVNIAETPSDLFNAILVETPLAPFFQDCTSENALDELNIEILRNKLYKSYIEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITLNSFGTELSKEDRETLYPTCGKLHPEGLRLLAQAEDFEQMKRVADSYGVYKPLFEAVSDSSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYTKLKEQEMRNIVWIAECISQRQRTKINSYIPIL", "length": 351, "header": "sp|Q2KJB6-1|VA0D2_BOVIN Isoform 1 of V-type proton ATPase subunit d 2 OS=Bos taurus OX=9913 GN=ATP6V0D2 PE=2 SV=1 CANONICAL=Q2KJB6-1" }, "locus": { "chromosome": "14", "start_pos": 76586146, "end_pos": 76530968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028091.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028091.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028091.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028091.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511839", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511839", "resource": "KEGG Pathway" }, { "id": "R-BTA-1222556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1222556", "resource": "Reactome", "description": "ROS and RNS production in phagocytes" }, { "id": "R-BTA-77387", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77387", "resource": "Reactome", "description": "Insulin receptor recycling" }, { "id": "R-BTA-917977", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917977", "resource": "Reactome", "description": "Transferrin endocytosis and recycling" }, { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" }, { "id": "R-BTA-983712", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983712", "resource": "Reactome", "description": "Ion channel transport" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RXD2-1", "protein_name": "V-type proton ATPase subunit", "gene_name": "ATP6V0D2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFEGAELYFNVDHGYLEGLVRGCKAGLLTQQDYINLVQCETLEDLKIHLQTTDYGNFLANQPNPLTVSIIDTEMRKKLCREFEYFRNHSLEPLSTFLTYMTCSYMIDNVILLMNGALQKKSVKEILVKCHPLGRFTEMEAVNIAETPSDLFNAILVETPLAPFFQDCMSENTLDELNIEILRNKLYKSYIETFYKFCKNHGDVTAEIMCPILEFEADRRAFIITLNSFGTELSKEDRKTLYPTCGKLYPEGLRLLAQAEDFEQMKRVADHYGVYKPLFEAVGDGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYTKLKEQEIRNVVWIAECISQRHRTKINSYIPIL", "length": 351 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5FVL0-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "Atp6v0d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLETAELYFNVDHGYLEGLVRGCKASLLTQQDYVNLVQCETLEDLKIHLQTTDYGNFLAHETNPLTVSKIDTEMRKKLCREFDYFRNHSLEPLSTFFTYMTCSYMIDNIILLMNGALQKKSVKEVLAKCHPLGRFTEMEAVNIAESASELFKAVLVETPLAPFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKDHGDVTAEVMCPILEFEADRRALIITLNSFGTELSKEDRETLFPTCGKLYPEGLRLLAQAEDFEHMKRVADNYGVYKPLFDAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAECISQRHRTKINSYIPIL", "length": 350 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZHL0-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGYSEFYFNVDHGYLEGLVRGFKAGILTSADYVNLAQCETLEDLKLHLQTTDYGNFLANESGPLTISTIDDKLKTKLLTEFHYFRNHAFEPLTTFLNFITYSYMIDNIILLITGTLHQRPIAELVPKCHPLGSFEQMEAVSIASNPTELFNAILVDTPLAAFFQDCLSENDLDEMNVEIMRNKLYKSYLEAFYKFCEKQGGTTAEIMKPILEFEADRRAFIITINSFGTELSKEDREKLYPTCGKLYPEGLHLLANADDYEQVKCVADYYAEYKAVFEGVGNDSGEKTLEDAFFEHEIKLNVLAFNNQFHFGVFYAYIKLKEQECRNIVWIAECISQRHRTKINNYIPIF", "length": 351 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q80SY3-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "Atp6v0d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLETAELYFNVDHGYLEGLVRGCKASLLTQQDYVNLVQCETLEDLKIHLQTTDYGNFLANETNPLTVSKIDTEMRKKLCREFDYFRNHSLEPLSTFLTYMTCSYMIDNIILLMNGALQKKSVKEVLAKCHPLGRFTEMEAVNIAETPSDLFKAVLVETPLAPFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKDHGDVTADVMCPILEFEADRRALIITLNSFGTELSKEDRETLFPTCGRLYPEGLRLLAQAEDFEQMKRVADNYGVYKPLFDAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAECISQRHRTKINSYIPIL", "length": 350 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLEGAELYFNVDHGYLEGLVRGCKASLLTQQDYINLVQCETLEDLKIHLQTTDYGNFLANHTNPLTVSKIDTEMRKRLCGEFEYFRNHSLEPLSTFLTYMTCSYMIDNVILLMNGALQKKSVKEILGKCHPLGRFTEMEAVNIAETPSDLFNAILIETPLAPFFQDCMSENALDELNIELLRNKLYKSYLEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITLNSFGTELSKEDRETLYPTFGKLYPEGLRLLAQAEDFDQMKNVADHYGVYKPLFEAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEIRNIVWIAECISQRHRTKINSYIPIL", "length": 350 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9LJI5-1", "protein_name": "V-type proton ATPase subunit d1", "gene_name": "VHA-d1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYGFEALTFNIHGGYLEAIVRGHRAGLLTTADYNNLCQCENLDDIKMHLSATKYGSYLQNEPSPLHTTTIVEKCTLKLVDDYKHMLCQATEPMSTFLEYIRYGHMIDNVVLIVTGTLHERDVQELIEKCHPLGMFDSIATLAVAQNMRELYRLVLVDTPLAPYFSECLTSEDLDDMNIEIMRNTLYKAYLEDFYKFCQKLGGATAEIMSDLLAFEADRRAVNITINSIGTELTREDRKKLYSNFGLLYPYGHEELAICEDIDQVRGVMEKYPPYQAIFSKMSYGESQMLDKAFYEEEVRRLCLAFEQQFHYAVFFAYMRLREQEIRNLMWISECVAQNQKSRIHDSVVYMF", "length": 351 }, "evidence": [ { "id": "Q2KJB6", "url": "https://omabrowser.org/oma/group/Q2KJB6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vacuolar transport", "id": "GO:0007034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007034", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" }, { "name": "vacuolar acidification", "id": "GO:0007035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007035", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" }, { "name": "vacuolar proton-transporting V-type ATPase complex", "id": "GO:0016471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016471", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" }, { "name": "proton-transporting V-type ATPase, V0 domain", "id": "GO:0033179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033179", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" }, { "name": "plasma membrane proton-transporting V-type ATPase complex", "id": "GO:0033181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033181", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proton-transporting ATPase activity, rotational mechanism", "id": "GO:0046961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046961", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB6", "url": "https://www.uniprot.org/uniprotkb/Q2KJB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJB6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJB9-1", "uniprot_ac": "Q2KJB9", "uniprot_id": "MSD4_BOVIN", "mass": { "chemical_mass": 41132.0, "monoisotopic_mass": 41132.0 }, "refseq": { "ac": "NP_001039543", "name": "myb/SANT-like DNA-binding domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039543" }, "gene_names": [ { "name": "MSANTD4", "type": "recommended", "evidence": [ { "id": "Q2KJB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ] }, { "name": "MSANTD4", "type": "synonym", "evidence": [ { "id": "NP_001039543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039543" } ] } ], "protein_names": [ { "name": "Myb/SANT-like DNA-binding domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q2KJB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9/entry#names_and_taxonomy" } ] }, { "name": "Myb/SANT-like DNA-binding domain containing 4 with coiled-coils", "type": "synonym", "evidence": [ { "id": "NP_001039543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039543" } ] }, { "name": "myb/SANT-like DNA-binding domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001039543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039543" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSANTD4", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9", "locus": { "chromosome": "15", "start_pos": 1776398, "end_pos": 1765992, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023989", "url": "https://www.ensembl.org/id/ENSBTAG00000023989" } ] } } ], "crossref": [ { "id": "Q2KJB9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023989", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023989", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511226", "url": "https://www.ncbi.nlm.nih.gov/gene/511226", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511226", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511226", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WLKANIK", "url": "https://omabrowser.org/oma/group/WLKANIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJB9", "url": "https://www.orthodb.org/?gene=Q2KJB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21732", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21732:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21732:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13873", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13873", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJB9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKKMKANIKLVGSGFPLPTSDLDDSLTEEIDEKIGFRSDTNFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRSAYDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLESELGQGEKSIHQPQDIETEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLQ", "length": 345, "header": "sp|Q2KJB9-1|MSD4_BOVIN Isoform 1 of Myb/SANT-like DNA-binding domain-containing protein 4 OS=Bos taurus OX=9913 GN=MSANTD4 PE=2 SV=1 CANONICAL=Q2KJB9-1" }, "isoforms": [ { "isoform_ac": "Q2KJB9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9/entry#Q2KJB9-1", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKKMKANIKLVGSGFPLPTSDLDDSLTEEIDEKIGFRSDTNFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRSAYDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLESELGQGEKSIHQPQDIETEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLQ", "length": 345, "header": "sp|Q2KJB9-1|MSD4_BOVIN Isoform 1 of Myb/SANT-like DNA-binding domain-containing protein 4 OS=Bos taurus OX=9913 GN=MSANTD4 PE=2 SV=1 CANONICAL=Q2KJB9-1" }, "locus": { "chromosome": "15", "start_pos": 1774756, "end_pos": 1773376, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033028.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033028.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032954.2", "url": "https://www.ensembl.org/id/ENSBTAP00000032954.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ], "site_lbl": "Ser106" }, { "start_pos": 188, "end_pos": 188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ], "site_lbl": "Thr188" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511226", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511226", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C0N5-1", "protein_name": "Myb/SANT DNA binding domain containing 4 with coiled-coils", "gene_name": "MSANTD4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEIRKRREVLFSKQLNTTINEMKRKAWEEIAECVNAVGEGEQRTGTEVKRRYLDWRALMKRKRLNANIKAVGAGFHLPSSDLDDSLNEDMDDKMGFANESSFEWQNITDFREAGGSLTEIKVEEEEEDPQNFEFPIEEEEIFSSVLPDSKKENDLPDFTHIEEFGNLSSAQARLAYEDSHLLINLEKQKVELEKQRLDIEAERLQVEKERLQIEKERLRHIDLEHERLQLEKERLQIEREKLRLETLRAEKPALENDLTQSEKPIIQPLDLETEKLKLEKERLQLEKERLQFLKFESEKLQIEKERLQVEKERLRIQREGLLQ", "length": 344 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SV33-1", "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "MSANTD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANIKLVGSGFPLPTSDLDDSLTEEIDEKIGFRNDTNFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRSAFDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLENELGQGEKSIHQPPDIETEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLQ", "length": 345 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HPN2-1", "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "Msantd4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANMKLVGSGFPLPTSDLDDSLTEEIDEKIAFRNDANFDWQNVSDFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRESELPDFPHIDEFFTLNSTPSRPSYDEPHLLMNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDLEHERLQLEKERLQIEREKWRLQLVSAEKPAIDNELGQGEKSMLQPQDIEAEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLP", "length": 345 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q501L3-1", "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "Msantd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANMKLVGSGFPLPTSDLDDSLTEDIDEKIAFRNDANFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRPTYDEPHLLMNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDLEHERLQLEKERLQIEREKWRLQLVSTEKPALENELGQGEKSMLQPQDIEAEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLP", "length": 345 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NCY6-1", "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "MSANTD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANIKLVGSGFPLPSSDLDDSLTEEIDEKIGFRNDANFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRSAYDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLENELGQGEKSMLQPQDIETEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKDRLRIQKEGHLQ", "length": 345 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91YU3-1", "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "Msantd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANMKLVGSGFPLPTSDLDDSLTEDIDEKIAFRNDANFEWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRPTYDEPHLLMNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDLEHERLQLEKERLQIEREKWRLQLVSTEKPALENELGQGEKSMLQPQDIEAEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKERLRIQKEGHLP", "length": 345 }, "evidence": [ { "id": "Q2KJB9", "url": "https://omabrowser.org/oma/group/Q2KJB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2KJB9", "url": "https://www.uniprot.org/uniprotkb/Q2KJB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJB9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 106, 188 ], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2KJE1-1", "uniprot_ac": "Q2KJE1", "uniprot_id": "GPTC4_BOVIN", "mass": { "chemical_mass": 46797.0, "monoisotopic_mass": 46797.0 }, "refseq": { "ac": "NP_001071597", "name": "G patch domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071597" }, "gene_names": [ { "name": "GPATCH4", "type": "recommended", "evidence": [ { "id": "Q2KJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ] }, { "name": "GPATC4", "type": "synonym", "evidence": [ { "id": "NP_001071597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071597" }, { "id": "Q2KJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ] }, { "name": "GPATCH4", "type": "synonym", "evidence": [ { "id": "NP_001071597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071597" } ] } ], "protein_names": [ { "name": "G patch domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q2KJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#names_and_taxonomy" } ] }, { "name": "G patch domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001071597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071597" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPATCH4", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1", "locus": { "chromosome": "3", "start_pos": 14240973, "end_pos": 14232932, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000406", "url": "https://www.ensembl.org/id/ENSBTAG00000000406" } ] } } ], "crossref": [ { "id": "Q2KJE1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000406", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768314", "url": "https://www.ncbi.nlm.nih.gov/gene/768314", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768314", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768314", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M6E2", "url": "https://www.orthodb.org/?gene=A0A3Q1M6E2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJX1", "url": "https://www.orthodb.org/?gene=A0A3Q1MJX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2KJE1", "url": "https://www.orthodb.org/?gene=Q2KJE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23149:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23149:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6E2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6E2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJX1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJE1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSITPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTYGVGHDPAKEFTNHWWNDLFNKTAANLVVETRQDGVQIRRLSKETTRQDHAKPNLLYQKFVKTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 408, "header": "sp|Q2KJE1-1|GPTC4_BOVIN Isoform 1 of G patch domain-containing protein 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=2 SV=1 CANONICAL=Q2KJE1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6E2-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#A0A3Q1M6E2-1", "sequence": { "sequence": "MSITPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTYGVGHDPAKEFTNHWWNDLFNKTAANLVVETRQTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 379, "header": "tr|A0A3Q1M6E2-1|A0A3Q1M6E2_BOVIN Computationally mapped isoform of G patch domain-containing protein 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=4 SV=2 CANONICAL=Q2KJE1-1" }, "locus": { "chromosome": "3", "start_pos": 14240518, "end_pos": 14236220, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074677.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074677.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065937.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065937.2" } ] } }, { "isoform_ac": "A0A3Q1MJX1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#A0A3Q1MJX1-1", "sequence": { "sequence": "MSITPEVKSRGMKFAEEQLLKHGWTQGRGMTSPEFTFLWQVGHDPAKEFTNHWWNDLFNKTAANLVVETRQDGVQIRRLSKETTRQDHAKPNLLYQKFVKTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 397, "header": "tr|A0A3Q1MJX1-1|A0A3Q1MJX1_BOVIN Computationally mapped isoform of G-patch domain containing 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=4 SV=1 CANONICAL=Q2KJE1-1" }, "locus": { "chromosome": "3", "start_pos": 14240518, "end_pos": 14236220, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070800.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070800.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071694.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071694.1" } ] } }, { "isoform_ac": "A0AAA9RTN8-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#A0AAA9RTN8-1", "sequence": { "sequence": "MQTVWRGKGLGRKENGITQALRVTLKQDTYGVGHDPAKEFTNHWWNDLFNKTAANLVVETRQDGVQIRRLSKETTRQDHAKPNLLYQKFVKTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 388, "header": "tr|A0AAA9RTN8-1|A0AAA9RTN8_BOVIN Computationally mapped isoform of G patch domain-containing protein 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=4 SV=1 CANONICAL=Q2KJE1-1" }, "locus": { "chromosome": "3", "start_pos": 14240518, "end_pos": 14236576, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122332.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122332.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075312.1" } ] } }, { "isoform_ac": "A0AAF6ZBJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#A0AAF6ZBJ5-1", "sequence": { "sequence": "MDDSDCFFSSESLKIVTFLTMSITPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTYGVGHDPAKEFTNHWWNDLFNKTAANLVVETRQDGVQIRRLSKETTRQDHAKPNLLYQKFVKTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 428, "header": "tr|A0AAF6ZBJ5-1|A0AAF6ZBJ5_BOVIN Computationally mapped isoform of G patch domain-containing protein 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=4 SV=1 CANONICAL=Q2KJE1-1" }, "locus": { "chromosome": "3", "start_pos": 14240518, "end_pos": 14234071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033914.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033914.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033817.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033817.4" } ] } }, { "isoform_ac": "Q2KJE1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1/entry#Q2KJE1-1", "sequence": { "sequence": "MSITPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTYGVGHDPAKEFTNHWWNDLFNKTAANLVVETRQDGVQIRRLSKETTRQDHAKPNLLYQKFVKTATLTSSGEKPDKDWESCSDDDSQEPKPPNVLTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLAQLKGQDPGVPQLQSESKSPKKKKKKRKQKEEEEPTTTERSAEKYSEHTDESIRKSKKKKRQHQEERVTDEREGTAIENEEETIRTGGLGELKNREHVDRSFRKKKRRGQHHEERAELAVLDNEGGKVAVSEVGTEEAERRVYTHPCGRSKKRRQHEEEDLNTEDEEVEEALVDSGTREAESRSCSDQKRGRSKKKRRQYQEEEVLDGPGVNTAQKAKKKKQKKRD", "length": 408, "header": "sp|Q2KJE1-1|GPTC4_BOVIN Isoform 1 of G patch domain-containing protein 4 OS=Bos taurus OX=9913 GN=GPATCH4 PE=2 SV=1 CANONICAL=Q2KJE1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 116, "end_pos": 116, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "site_lbl": "Thr116" }, { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "site_lbl": "Ser128" }, { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "site_lbl": "Ser130" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "site_lbl": "Thr4" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768314", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768314", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q2KJE1", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJE1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 408, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJE1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJE1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE1" }, { "id": "PRU00092", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00092" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 57, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 4, 116, 128, 130 ], "sequon_annotation_sites": [ { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJF9-1", "uniprot_ac": "Q2KJF9", "uniprot_id": "T2EB_BOVIN", "mass": { "chemical_mass": 32731.0, "monoisotopic_mass": 32731.0 }, "refseq": { "ac": "NP_001039530", "name": "general transcription factor IIE subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" }, "gene_names": [ { "name": "GTF2E2", "type": "recommended", "evidence": [ { "id": "Q2KJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ] }, { "name": "GTF2E2", "type": "synonym", "evidence": [ { "id": "NP_001039530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" } ] } ], "protein_names": [ { "name": "General transcription factor IIE subunit 2", "type": "recommended", "evidence": [ { "id": "Q2KJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9/entry#names_and_taxonomy" } ] }, { "name": "TFIIE-beta", "type": "synonym", "evidence": [ { "id": "NP_001039530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" }, { "id": "Q2KJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9/entry#names_and_taxonomy" } ] }, { "name": "Transcription initiation factor IIE subunit beta", "type": "synonym", "evidence": [ { "id": "Q2KJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor IIE subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001039530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" } ] }, { "name": "general transcription factor IIE, polypeptide 2, beta 34kDa", "type": "synonym", "evidence": [ { "id": "NP_001039530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" } ] }, { "name": "transcription initiation factor IIE subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001039530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530" } ] } ], "function": [ { "annotation": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9#function" }, { "database": "UniProtKB", "id": "P29084", "url": "https://www.uniprot.org/uniprotkb/P29084#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF2E2", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9", "locus": { "chromosome": "27", "start_pos": 26642015, "end_pos": 26783526, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012691", "url": "https://www.ensembl.org/id/ENSBTAG00000012691" } ] } } ], "crossref": [ { "id": "Q2KJF9", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07977", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07977", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510921", "url": "https://www.ncbi.nlm.nih.gov/gene/510921", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510921", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510921", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJF9", "url": "https://www.orthodb.org/?gene=Q2KJF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12716:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12716:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18121", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18121", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039530", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJF9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSLLRERELFKKRALSTPAVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDIAPGK", "length": 289, "header": "sp|Q2KJF9-1|T2EB_BOVIN Isoform 1 of General transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=2 SV=1 CANONICAL=Q2KJF9-1" }, "isoforms": [ { "isoform_ac": "Q2KJF9-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9/entry#Q2KJF9-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPAVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDIAPGK", "length": 289, "header": "sp|Q2KJF9-1|T2EB_BOVIN Isoform 1 of General transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=2 SV=1 CANONICAL=Q2KJF9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "site_lbl": "Ser59" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510921", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510921", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "transcription factor TFIIE complex", "id": "GO:0005673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005673", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "Q2KJF9", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJF9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 289, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJF9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJF9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2KJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJF9" }, { "id": "PRU00682", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00682" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "TFIIE beta", "eco_id": "ECO_0000255", "start_pos": 64, "end_pos": 144, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 59 ], "sequon_annotation_sites": [ { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJG3-1", "uniprot_ac": "Q2KJG3", "uniprot_id": "SYNC_BOVIN", "mass": { "chemical_mass": 64399.0, "monoisotopic_mass": 64399.0 }, "refseq": { "ac": "NP_001040037", "name": "asparagine--tRNA ligase, cytoplasmic", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" }, "gene_names": [ { "name": "NARS", "type": "recommended", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ] }, { "name": "NARS1", "type": "synonym", "evidence": [ { "id": "NP_001040037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" } ] }, { "name": "NARS", "type": "synonym", "evidence": [ { "id": "NP_001040037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" } ] } ], "protein_names": [ { "name": "Asparagine--tRNA ligase, cytoplasmic", "type": "recommended", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.22", "type": "synonym", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3/entry#names_and_taxonomy" } ] }, { "name": "AsnRS", "type": "synonym", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3/entry#names_and_taxonomy" } ] }, { "name": "Asparaginyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3/entry#names_and_taxonomy" } ] }, { "name": "asnRS", "type": "synonym", "evidence": [ { "id": "NP_001040037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" } ] }, { "name": "asparagine--tRNA ligase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001040037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" } ] }, { "name": "asparaginyl-tRNA synthetase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001040037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NARS", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3", "locus": {} } ], "crossref": [ { "id": "Q2KJG3", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00776", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00776", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04323", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04323", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616033", "url": "https://www.ncbi.nlm.nih.gov/gene/616033", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004522", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004522", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616033", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616033", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJG3", "url": "https://www.orthodb.org/?gene=Q2KJG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22594", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22594:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00152", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00152", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01336", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01336", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20917", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20917", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040037", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11180", "url": "https://www.rhea-db.org/rhea/11180", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJG3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLEVVRAAAGMVLAELYVSDREGNDVTGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWDVISKSQMKNIRKLWHREQMKSESREKKEAEDNLRREKNLEEAKKITIKNDPSLPEPKCVKIRELKGYRGQRIKVFGWVHRLRRQGKNLMFLVLRDGTGFLQCVLSDDLCQCYNGVVLSTESSVAVYGVLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSVITRCFRDHFFDRGYHEITPPTLVQTQVEGGATLFKLDYFGEEAYLTQSSQLYLETCIPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFEELLNRLEDLVCDVVDRVLKSPAGNIVRDLNPNFKPPKRPFKRMNYSDAIVWLKEHNIKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRIWDNEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILDRYHIRDVCLYPRFVQRCKP", "length": 559, "header": "sp|Q2KJG3-1|SYNC_BOVIN Isoform 1 of Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=NARS PE=2 SV=3 CANONICAL=Q2KJG3-1" }, "isoforms": [ { "isoform_ac": "Q2KJG3-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3/entry#Q2KJG3-1", "sequence": { "sequence": "MSLEVVRAAAGMVLAELYVSDREGNDVTGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWDVISKSQMKNIRKLWHREQMKSESREKKEAEDNLRREKNLEEAKKITIKNDPSLPEPKCVKIRELKGYRGQRIKVFGWVHRLRRQGKNLMFLVLRDGTGFLQCVLSDDLCQCYNGVVLSTESSVAVYGVLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSVITRCFRDHFFDRGYHEITPPTLVQTQVEGGATLFKLDYFGEEAYLTQSSQLYLETCIPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFEELLNRLEDLVCDVVDRVLKSPAGNIVRDLNPNFKPPKRPFKRMNYSDAIVWLKEHNIKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRIWDNEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILDRYHIRDVCLYPRFVQRCKP", "length": 559, "header": "sp|Q2KJG3-1|SYNC_BOVIN Isoform 1 of Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=NARS PE=2 SV=3 CANONICAL=Q2KJG3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 508, "start_aa": "Thr", "end_pos": 508, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr508", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 72, "end_pos": 72, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "site_lbl": "Ser72" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616033", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616033", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "pmid": "" }, { "name": "asparagine-tRNA ligase activity", "id": "GO:0004816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004816", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "asparaginyl-tRNA aminoacylation", "id": "GO:0006421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006421", "evidence": [ { "database": "UniProtKB", "id": "Q2KJG3", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11180", "name": "", "equation": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJG3-1", "A0A3Q1M1K1-1" ], "evidence": [ { "id": "11180", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11180" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M1K1", "gene_name": "NARS1", "activity": [ { "ec_number": "6.1.1.22", "activity": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0A3Q1M1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ] }, { "ec_number": "6.1.1.22", "activity": "", "evidence": [ { "id": "A0A3Q1M1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ] } ] }, { "uniprot_ac": "Q2KJG3", "gene_name": "NARS", "activity": [ { "ec_number": "6.1.1.22", "activity": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ] }, { "ec_number": "6.1.1.22", "activity": "", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJG3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 559, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJG3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJG3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.22", "ec_name": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.22" }, { "id": "6.1.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.22" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 508 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 72 ], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 403, "end_pos": 405 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJH5-1", "uniprot_ac": "Q2KJH5", "uniprot_id": "CFA97_BOVIN", "mass": { "chemical_mass": 58670.0, "monoisotopic_mass": 58670.0 }, "refseq": { "ac": "NP_001039464", "name": "cilia- and flagella-associated protein 97", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039464" }, "gene_names": [ { "name": "CFAP97", "type": "recommended", "evidence": [ { "id": "Q2KJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ] }, { "name": "CFAP97", "type": "synonym", "evidence": [ { "id": "NP_001039464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039464" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein 97", "type": "recommended", "evidence": [ { "id": "Q2KJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5/entry#names_and_taxonomy" } ] }, { "name": "cilia- and flagella-associated protein 97", "type": "synonym", "evidence": [ { "id": "NP_001039464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039464" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP97", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5", "locus": { "chromosome": "27", "start_pos": 15497436, "end_pos": 15516152, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013211", "url": "https://www.ensembl.org/id/ENSBTAG00000013211" } ] } } ], "crossref": [ { "id": "Q2KJH5", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "508280", "url": "https://www.ncbi.nlm.nih.gov/gene/508280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508280", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508280", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2KJH5", "url": "https://www.orthodb.org/?gene=Q2KJH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23035:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23035:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13879", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13879", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039464", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJH5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRFDDISEGEVDHSFFDSDFEEARKGDSSSVFDKQDDDAEERTDKDTENVNLKLGLQRKEDDLTEKGTESSGKTPPEEHPVEGDNAQTGNSSSSTTSSRSKLGNARVEHKIHLPTPNSLPQTVKDGEHDYYTDGEESTDDEKKHHVRSKSAKLPNNFKKSLSKKYSRSSSSSSLSLSSSSSDTGCSDTGSDVGLSDSSPSPKKHLPGATHLSPKLKYKPGEKSPGAHASGTKPKVGDDAEESEDTVTDVTPLSTPDISPVQSFELGASSDRKMKVKRQENVRQEVYENVEDLKNNSKSLKSAKKGKEKHEPSLTSKSTALDSSLDHRYKQKVLHDTMDLNHLLKAFLQLDKKRPQKHHFDQPSVAPRKNYSFTREEVRQIDRENQRLLKELSRQAEKPGSKSMIPRSTGPPPKLYHSALNRQREQQRIERENLAFLKRLEAVKPTVGMKRSEQLMDYHRNMGYLSSSPISRRVRSTLSQYSSLKGASRTSSATSGLSCKSERSAFNTTGGGLLLRPKPPNVRTAWL", "length": 527, "header": "sp|Q2KJH5-1|CFA97_BOVIN Isoform 1 of Cilia- and flagella-associated protein 97 OS=Bos taurus OX=9913 GN=CFAP97 PE=2 SV=1 CANONICAL=Q2KJH5-1" }, "isoforms": [ { "isoform_ac": "Q2KJH5-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5/entry#Q2KJH5-1", "sequence": { "sequence": "MDRFDDISEGEVDHSFFDSDFEEARKGDSSSVFDKQDDDAEERTDKDTENVNLKLGLQRKEDDLTEKGTESSGKTPPEEHPVEGDNAQTGNSSSSTTSSRSKLGNARVEHKIHLPTPNSLPQTVKDGEHDYYTDGEESTDDEKKHHVRSKSAKLPNNFKKSLSKKYSRSSSSSSLSLSSSSSDTGCSDTGSDVGLSDSSPSPKKHLPGATHLSPKLKYKPGEKSPGAHASGTKPKVGDDAEESEDTVTDVTPLSTPDISPVQSFELGASSDRKMKVKRQENVRQEVYENVEDLKNNSKSLKSAKKGKEKHEPSLTSKSTALDSSLDHRYKQKVLHDTMDLNHLLKAFLQLDKKRPQKHHFDQPSVAPRKNYSFTREEVRQIDRENQRLLKELSRQAEKPGSKSMIPRSTGPPPKLYHSALNRQREQQRIERENLAFLKRLEAVKPTVGMKRSEQLMDYHRNMGYLSSSPISRRVRSTLSQYSSLKGASRTSSATSGLSCKSERSAFNTTGGGLLLRPKPPNVRTAWL", "length": 527, "header": "sp|Q2KJH5-1|CFA97_BOVIN Isoform 1 of Cilia- and flagella-associated protein 97 OS=Bos taurus OX=9913 GN=CFAP97 PE=2 SV=1 CANONICAL=Q2KJH5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 446, "start_aa": "Thr", "end_pos": 446, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr446", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Thr133" }, { "start_pos": 138, "end_pos": 138, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser138" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser19" }, { "start_pos": 213, "end_pos": 213, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser213" }, { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser243" }, { "start_pos": 324, "end_pos": 324, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser324" }, { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2KJH5", "url": "https://www.uniprot.org/uniprotkb/Q2KJH5" } ], "site_lbl": "Ser8" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508280", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508280", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 527, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 446 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 8, 19, 133, 138, 213, 243, 324 ], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 507, "end_pos": 509 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2KJI1-1", "uniprot_ac": "Q2KJI1", "uniprot_id": "CKS2_BOVIN", "mass": { "chemical_mass": 9860.0, "monoisotopic_mass": 9860.0 }, "refseq": { "ac": "NP_001106790", "name": "cyclin-dependent kinases regulatory subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106790" }, "gene_names": [ { "name": "CKS2", "type": "recommended", "evidence": [ { "id": "Q2KJI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ] }, { "name": "CKS2", "type": "synonym", "evidence": [ { "id": "NP_001106790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106790" } ] } ], "protein_names": [ { "name": "Cyclin-dependent kinases regulatory subunit 2", "type": "recommended", "evidence": [ { "id": "Q2KJI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1/entry#names_and_taxonomy" } ] }, { "name": "CKS-2", "type": "synonym", "evidence": [ { "id": "NP_001106790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106790" }, { "id": "Q2KJI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1/entry#names_and_taxonomy" } ] }, { "name": "cyclin-dependent kinases regulatory subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001106790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106790" } ] } ], "function": [ { "annotation": "Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKS2", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1", "locus": { "chromosome": "8", "start_pos": 88791408, "end_pos": 88796302, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001938", "url": "https://www.ensembl.org/id/ENSBTAG00000001938" } ] } } ], "crossref": [ { "id": "Q2KJI1", "url": "https://alphafold.ebi.ac.uk/entry/Q2KJI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767985", "url": "https://www.ncbi.nlm.nih.gov/gene/767985", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767985", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767985", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MHEPEPH", "url": "https://omabrowser.org/oma/group/MHEPEPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2KJI1", "url": "https://www.orthodb.org/?gene=Q2KJI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01111", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01111", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001106790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106790", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2KJI1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK", "length": 79, "header": "sp|Q2KJI1-1|CKS2_BOVIN Isoform 1 of Cyclin-dependent kinases regulatory subunit 2 OS=Bos taurus OX=9913 GN=CKS2 PE=3 SV=1 CANONICAL=Q2KJI1-1" }, "isoforms": [ { "isoform_ac": "Q2KJI1-1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1/entry#Q2KJI1-1", "sequence": { "sequence": "MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK", "length": 79, "header": "sp|Q2KJI1-1|CKS2_BOVIN Isoform 1 of Cyclin-dependent kinases regulatory subunit 2 OS=Bos taurus OX=9913 GN=CKS2 PE=3 SV=1 CANONICAL=Q2KJI1-1" }, "locus": { "chromosome": "8", "start_pos": 88796200, "end_pos": 88791693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002522.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002522.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002522.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002522.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767985", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PGD2-1", "protein_name": "Cyclin-dependent kinases regulatory subunit", "gene_name": "CKS2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAHKDIYYSDKYFDEQYEYRHVMLPRELLKRMPKAHLLSEEEWRSLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDDQK", "length": 79 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1SFE7-1", "protein_name": "Cyclin-dependent kinases regulatory subunit", "gene_name": "CKS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK", "length": 79 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6ACB4-1", "protein_name": "Cyclin-dependent kinases regulatory subunit", "gene_name": "Cks2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVHKQIYYSDKYFDEQYEYWHVMLPRELSKQVLKTHLMSEEEWRRLGVQQSLGWAHDMIHEPEPHSLLFRRPLPKEQQK", "length": 79 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P33552-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 2", "gene_name": "CKS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK", "length": 79 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P56390-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 2", "gene_name": "Cks2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK", "length": 79 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SJJ5-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 2", "gene_name": "CKS2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGQIQYSDKYFDDTFEYRHVVLPPEVAKLLPKNRILSESEWRAIGVQQSRGWVHYAIHRPEPHIMLFRRPLNYQQEHQAQIAK", "length": 83 }, "evidence": [ { "id": "Q2KJI1", "url": "https://omabrowser.org/oma/group/Q2KJI1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "Q2KJI1", "url": "https://www.uniprot.org/uniprotkb/Q2KJI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2KJI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 79, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2KJI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2KJI1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2S5-1", "uniprot_ac": "Q2M2S5", "uniprot_id": "COA6_BOVIN", "mass": { "chemical_mass": 9417.0, "monoisotopic_mass": 9417.0 }, "refseq": { "ac": "NP_001193571", "name": "cytochrome c oxidase assembly factor 6 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193571" }, "gene_names": [ { "name": "COA6", "type": "recommended", "evidence": [ { "id": "Q2M2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ] }, { "name": "C28H1orf31", "type": "synonym", "evidence": [ { "id": "NP_001193571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193571" } ] }, { "name": "COA6", "type": "synonym", "evidence": [ { "id": "NP_001193571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193571" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly factor 6 homolog", "type": "recommended", "evidence": [ { "id": "Q2M2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5/entry#names_and_taxonomy" } ] }, { "name": "cytochrome c oxidase assembly factor 6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001193571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193571" } ] } ], "function": [ { "annotation": "Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5#function" }, { "database": "UniProtKB", "id": "Q5JTJ3", "url": "https://www.uniprot.org/uniprotkb/Q5JTJ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COA6", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5", "locus": {} } ], "crossref": [ { "id": "Q2M2S5", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051467", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051467", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00926", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00926", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768072", "url": "https://www.ncbi.nlm.nih.gov/gene/768072", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768072", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768072", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DAPRCEK", "url": "https://omabrowser.org/oma/group/DAPRCEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2M2S5", "url": "https://www.orthodb.org/?gene=Q2M2S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46690:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46690:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193571", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2S5-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPTMKERQACWGARDEYWKCLDENTEDASKCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGDFQPSKMTAKS", "length": 79, "header": "sp|Q2M2S5-1|COA6_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 6 homolog OS=Bos taurus OX=9913 GN=COA6 PE=3 SV=1 CANONICAL=Q2M2S5-1" }, "isoforms": [ { "isoform_ac": "Q2M2S5-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5/entry#Q2M2S5-1", "sequence": { "sequence": "MAAPTMKERQACWGARDEYWKCLDENTEDASKCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGDFQPSKMTAKS", "length": 79, "header": "sp|Q2M2S5-1|COA6_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 6 homolog OS=Bos taurus OX=9913 GN=COA6 PE=3 SV=1 CANONICAL=Q2M2S5-1" }, "locus": { "chromosome": "28", "start_pos": 7196865, "end_pos": 7189393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105376.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768072", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768072", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XR31-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "COA6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAPTMEERKACWAARDEFWRCLDTHTEDAPRCEKLRRSFESLCPQQWVKYFDKRRDFLKYKEKLETEGFHPAETDGKS", "length": 79 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LE58-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "Coa6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERKVQGASCMANLSFTVTQSQRSLESDLLLNTQRREHGAGSVSSAHSESLLSQSGPPQLRTVFPHGAEGGTNQTLVSVHGPRLRGRKLPAREKDANGSPALPFADGGQDQSIRGGHFRSELPCTVGGPAGRQCSTHSPHRAPTWADPRVARHVAPRVTPAGMAAPSMKERQACWGARDLYWRCLDDNAEDAARCQKLRSSFEASCPQQWIKYFDKRRDYLKFKEKFEAGEFQSSPSTENS", "length": 242 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B8A5J2-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "coa6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAPNASQRKACWDARDELWKCLDVNKDLTSACEKHQREFEANCPAQWVKYFSKRRDFLKYKEKIEKEGYEPTEGASKL", "length": 79 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GWZ0-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "LOC100761903", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPSMKERQVCWGARDLYWRCLDDNAEDAARCRQLRSSFEASCPQQWIKYFDKRRDYLKFKEKFEAGEFQPSQSTENS", "length": 79 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5JTJ3-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "COA6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPGGPLLSPSRGFLLCKTGWHSNRLLGDCGPHTPVSTALSFIAVGMAAPSMKERQVCWGARDEYWKCLDENLEDASQCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGQFEPSETTAKS", "length": 125 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BGD8-1", "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "Coa6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPSMKERQACWGARDLYWRCLDDNAEDAARCQKLRSSFEASCPQQWIKYFDKRRDYLKFKEKFEAGGFQSSQSTENS", "length": 79 }, "evidence": [ { "id": "Q2M2S5", "url": "https://omabrowser.org/oma/group/Q2M2S5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "pmid": "" }, { "name": "respiratory chain complex IV assembly", "id": "GO:0008535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008535", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S5", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2S5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 79, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2S5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2S5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2M2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000255", "start_pos": 9, "end_pos": 52, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2M2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx10C motif", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 44, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2M2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S5" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif", "eco_id": "ECO_0000255", "start_pos": 12, "end_pos": 22, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2S9-1", "uniprot_ac": "Q2M2S9", "uniprot_id": "LYRM7_BOVIN", "mass": { "chemical_mass": 11923.0, "monoisotopic_mass": 11923.0 }, "refseq": { "ac": "NP_001069973", "name": "complex III assembly factor LYRM7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973" }, "gene_names": [ { "name": "LYRM7", "type": "recommended", "evidence": [ { "id": "Q2M2S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ] }, { "name": "LYRM7", "type": "synonym", "evidence": [ { "id": "NP_001069973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973" } ] }, { "name": "MZM1L", "type": "synonym", "evidence": [ { "id": "Q2M2S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ] } ], "protein_names": [ { "name": "Complex III assembly factor LYRM7", "type": "recommended", "evidence": [ { "id": "Q2M2S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9/entry#names_and_taxonomy" } ] }, { "name": "LYR motif-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001069973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973" }, { "id": "Q2M2S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9/entry#names_and_taxonomy" } ] }, { "name": "Lyrm7 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973" } ] }, { "name": "complex III assembly factor LYRM7", "type": "synonym", "evidence": [ { "id": "NP_001069973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973" } ] } ], "function": [ { "annotation": "Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYRM7", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9", "locus": { "chromosome": "7", "start_pos": 23243185, "end_pos": 23272728, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010961", "url": "https://www.ensembl.org/id/ENSBTAG00000010961" } ] } } ], "crossref": [ { "id": "Q2M2S9", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20267", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20267", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618451", "url": "https://www.ncbi.nlm.nih.gov/gene/618451", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618451", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618451", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2M2S9", "url": "https://www.orthodb.org/?gene=Q2M2S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46749", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46749", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46749:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46749:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069973", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2S9-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQAAKVLQLFKTLHRTRQQVFKNDARALEAARKKINEEFKCNKTETSPKKIEELIKIGSDVELILRTSVIQGIHTDHNTLKLVPRKDLLIENVPYCDAPTQKQ", "length": 104, "header": "sp|Q2M2S9-1|LYRM7_BOVIN Isoform 1 of Complex III assembly factor LYRM7 OS=Bos taurus OX=9913 GN=LYRM7 PE=3 SV=1 CANONICAL=Q2M2S9-1" }, "isoforms": [ { "isoform_ac": "Q2M2S9-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9/entry#Q2M2S9-1", "sequence": { "sequence": "MGQAAKVLQLFKTLHRTRQQVFKNDARALEAARKKINEEFKCNKTETSPKKIEELIKIGSDVELILRTSVIQGIHTDHNTLKLVPRKDLLIENVPYCDAPTQKQ", "length": 104, "header": "sp|Q2M2S9-1|LYRM7_BOVIN Isoform 1 of Complex III assembly factor LYRM7 OS=Bos taurus OX=9913 GN=LYRM7 PE=3 SV=1 CANONICAL=Q2M2S9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ], "site_lbl": "Ser60" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618451", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618451", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex III assembly", "id": "GO:0034551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034551", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q2M2S9", "url": "https://www.uniprot.org/uniprotkb/Q2M2S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2S9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2S9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2S9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 60 ], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2T3-1", "uniprot_ac": "Q2M2T3", "uniprot_id": "MPCX_BOVIN", "mass": { "chemical_mass": 19167.0, "monoisotopic_mass": 19167.0 }, "refseq": { "ac": "NP_001069277", "name": "mitochondrial pyruvate carrier-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069277" }, "gene_names": [ { "name": "MPC1L", "type": "synonym", "evidence": [ { "id": "NP_001069277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069277" } ] } ], "protein_names": [ { "name": "Mitochondrial pyruvate carrier-like protein", "type": "recommended", "evidence": [ { "id": "Q2M2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3/entry#names_and_taxonomy" } ] }, { "name": "Brain protein 44-like protein 2", "type": "synonym", "evidence": [ { "id": "Q2M2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3/entry#names_and_taxonomy" } ] }, { "name": "brain protein 44-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001069277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069277" } ] }, { "name": "mitochondrial pyruvate carrier-like protein", "type": "synonym", "evidence": [ { "id": "NP_001069277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069277" } ] } ], "function": [ { "annotation": "May mediate the uptake of pyruvate into mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3#function" }, { "database": "UniProtKB", "id": "P63030", "url": "https://www.uniprot.org/uniprotkb/P63030#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3", "locus": {} } ], "crossref": [ { "id": "Q2M2T3", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2T3", "database": "AlphaFoldDB", "categories": [] }, { "id": "520682", "url": "https://www.ncbi.nlm.nih.gov/gene/520682", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520682", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520682", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2M2T3", "url": "https://www.orthodb.org/?gene=Q2M2T3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2T3-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVVALCRKAMETVKTKEFRDYLASTHFWGPVANWGLPLAAFRDMRASPDIISGRMTTALIFYSMAFMRFAYRVQPRNLLLMACHGTNIVAQSMQAGRYLNYHYGGGTTAATTAAVSAASATSTGSVDSSATSTGSVDSSATSTGSVDSSAATTPAAEDPVAHSNCQEITCCYLVTWDCD", "length": 181, "header": "sp|Q2M2T3-1|MPCX_BOVIN Isoform 1 of Mitochondrial pyruvate carrier-like protein OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2M2T3-1" }, "isoforms": [ { "isoform_ac": "Q2M2T3-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3/entry#Q2M2T3-1", "sequence": { "sequence": "MAAVVALCRKAMETVKTKEFRDYLASTHFWGPVANWGLPLAAFRDMRASPDIISGRMTTALIFYSMAFMRFAYRVQPRNLLLMACHGTNIVAQSMQAGRYLNYHYGGGTTAATTAAVSAASATSTGSVDSSATSTGSVDSSATSTGSVDSSAATTPAAEDPVAHSNCQEITCCYLVTWDCD", "length": 181, "header": "sp|Q2M2T3-1|MPCX_BOVIN Isoform 1 of Mitochondrial pyruvate carrier-like protein OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2M2T3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520682", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520682", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "pyruvate transmembrane transporter activity", "id": "GO:0050833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050833", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "pyruvate import into mitochondria", "id": "GO:0006850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006850", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T3", "url": "https://www.uniprot.org/uniprotkb/Q2M2T3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2T3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 181, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2T3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2T3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2T9-1", "uniprot_ac": "Q2M2T9", "uniprot_id": "TERB2_BOVIN", "mass": { "chemical_mass": 25381.0, "monoisotopic_mass": 25381.0 }, "refseq": { "ac": "NP_001070546", "name": "telomere repeats-binding bouquet formation protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" }, "gene_names": [ { "name": "TERB2", "type": "recommended", "evidence": [ { "id": "Q2M2T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ] }, { "name": "C10H15orf43", "type": "synonym", "evidence": [ { "id": "NP_001070546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" } ] }, { "name": "C15orf43", "type": "synonym", "evidence": [ { "id": "NP_001070546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" } ] }, { "name": "TERB2", "type": "synonym", "evidence": [ { "id": "NP_001070546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" } ] } ], "protein_names": [ { "name": "Telomere repeats-binding bouquet formation protein 2", "type": "recommended", "evidence": [ { "id": "Q2M2T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9/entry#names_and_taxonomy" } ] }, { "name": "telomere repeats-binding bouquet formation protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" } ] }, { "name": "uncharacterized protein C15orf43 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546" } ] } ], "function": [ { "annotation": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9#function" }, { "database": "UniProtKB", "id": "Q9D494", "url": "https://www.uniprot.org/uniprotkb/Q9D494#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TERB2", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9", "locus": { "chromosome": "10", "start_pos": 103245518, "end_pos": 103201542, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005954", "url": "https://www.ensembl.org/id/ENSBTAG00000005954" } ] } } ], "crossref": [ { "id": "Q2M2T9", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005954", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005954", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768019", "url": "https://www.ncbi.nlm.nih.gov/gene/768019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768019", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WFCRSVS", "url": "https://omabrowser.org/oma/group/WFCRSVS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2M2T9", "url": "https://www.orthodb.org/?gene=Q2M2T9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35345:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35345:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15101", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15101", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070546", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2T9-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQGQRGWFCGSVSHDLRQFWVAEGGTISDPRAADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAEIKNSVALGHFILPPASLQKEIRRKIGSFIWEQDQHFLIEKHDEVTSNELKVFRESSVLATDHKKDLSKSTEKHFIRTPVVEKQMYFPLQHYPVNNMVTGYISIDAMKKFLGELHDFIPGSSGYLAYHVQNEINMSAIKNKLKNKY", "length": 221, "header": "sp|Q2M2T9-1|TERB2_BOVIN Isoform 1 of Telomere repeats-binding bouquet formation protein 2 OS=Bos taurus OX=9913 GN=TERB2 PE=2 SV=1 CANONICAL=Q2M2T9-1" }, "isoforms": [ { "isoform_ac": "Q2M2T9-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9/entry#Q2M2T9-1", "sequence": { "sequence": "MFQGQRGWFCGSVSHDLRQFWVAEGGTISDPRAADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAEIKNSVALGHFILPPASLQKEIRRKIGSFIWEQDQHFLIEKHDEVTSNELKVFRESSVLATDHKKDLSKSTEKHFIRTPVVEKQMYFPLQHYPVNNMVTGYISIDAMKKFLGELHDFIPGSSGYLAYHVQNEINMSAIKNKLKNKY", "length": 221, "header": "sp|Q2M2T9-1|TERB2_BOVIN Isoform 1 of Telomere repeats-binding bouquet formation protein 2 OS=Bos taurus OX=9913 GN=TERB2 PE=2 SV=1 CANONICAL=Q2M2T9-1" }, "locus": { "chromosome": "10", "start_pos": 103245512, "end_pos": 103201564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007813.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007813.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007813.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007813.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768019", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768019", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LNB2-1", "protein_name": "Telomere repeats-binding bouquet formation protein 2", "gene_name": "Terb2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFQGQRGWFCRSVSQDLRQFWVDEGGTVSDVQAADFLFSCDASHPDTLRIYQSLEYIEDNATVFHAYYLSAVANTEMKNSVALGHFVLPPACLQKEIRRKIGSFIWEQDENFLVKKHDRITSNERESSEPTTEHKKELYESAENHFVRTPVVEKQMYFPLQNYPVNNMVTGYISIDALEKFLGELHDFIPGSSGYLAYHVQNEINMSAIKNKLRRKLS", "length": 218 }, "evidence": [ { "id": "Q2M2T9", "url": "https://omabrowser.org/oma/group/Q2M2T9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A1L6-1", "protein_name": "Telomere repeat binding bouquet formation protein 2", "gene_name": "Terb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFQGQRGWFCRSVSQALRQFWVDQGGMVSDAQAADFLFSCDASHPDTLRIYQSLEYTEDSATVFHAYYLAAVANAEKKNSVALGHFVLPPACLQKEIRRKIGSFIWEQDEKFQIEKHSRATSSVKGSTGPTTEHKQELSKSTENHLIRTPAIEKQTCFPLQNYPVNNMVTGYVSIDTLEKFLGELRDFIPGNSGYLAYHVQNEINMSVIKNKLRRKLS", "length": 218 }, "evidence": [ { "id": "Q2M2T9", "url": "https://omabrowser.org/oma/group/Q2M2T9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SN26-1", "protein_name": "Telomere repeat binding bouquet formation protein 2", "gene_name": "TERB2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFQGQRGWFCGSVSGDLRQFWVAEGGTISDLRAADYLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAEIKNSVALGHFILPPACLQKEIRRKIGNFIWEQDQRFLLEKHDEVTPNEIKAFRESSELATDHKKELSTSTEKHFIRTPVVEKQMYFPLQNYPVNNMVTGYISIDAMKKFLGELHDFIPGSSGYLAYHVQNEINMSAIKNKLKRKY", "length": 221 }, "evidence": [ { "id": "Q2M2T9", "url": "https://omabrowser.org/oma/group/Q2M2T9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NHR7-1", "protein_name": "Telomere repeats-binding bouquet formation protein 2", "gene_name": "TERB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFQGQRGWFCGSVSQDLRQFWVAEGGTISDPRAADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAKIKNSVALGHFILPPACLQKEIRRKIGSFIWEQDQHFLIEKHDEVTPNEIKTLRENSELATEHKKELSKSPEKHFIRTPVVEKQMYFPLQNYPVNNMVTGYISIDAMKKFLGELHDFIPGTSGYLAYHVQNEINMSAIKNKLKRK", "length": 220 }, "evidence": [ { "id": "Q2M2T9", "url": "https://omabrowser.org/oma/group/Q2M2T9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D494-1", "protein_name": "Telomere repeats-binding bouquet formation protein 2", "gene_name": "Terb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQGQRGWFCGSVSQDLRQIWEDEGGMVSDVKAADFLFSCDASHPDTLRIYQSLEYIEDNATVFHAYYLAAIANTEMKNSVALGHFVLPPACLQKEIRRKIGSFIWEQDEKFQIEKHDRMASSDKENIRPTPEHKQELSKSAEHHLTRTPVIEKQMCFPLHSYPVNNMVTGYISIDALEKFLGELHDFTPGSSGYLAYHIQDEINMSAIKNKLRRKLS", "length": 218 }, "evidence": [ { "id": "Q2M2T9", "url": "https://omabrowser.org/oma/group/Q2M2T9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "meiotic attachment of telomere to nuclear envelope", "id": "GO:0070197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070197", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "pmid": "" }, { "name": "meiotic telomere clustering", "id": "GO:0045141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045141", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "Q2M2T9", "url": "https://www.uniprot.org/uniprotkb/Q2M2T9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2T9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 221, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2T9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2T9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 }, { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2M2U4-1", "uniprot_ac": "Q2M2U4", "uniprot_id": "RNH2C_BOVIN", "mass": { "chemical_mass": 18349.0, "monoisotopic_mass": 18349.0 }, "refseq": { "ac": "NP_001039386", "name": "ribonuclease H2 subunit C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" }, "gene_names": [ { "name": "RNASEH2C", "type": "recommended", "evidence": [ { "id": "Q2M2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4" } ] }, { "name": "RNASEH2C", "type": "synonym", "evidence": [ { "id": "NP_001039386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" } ] } ], "protein_names": [ { "name": "Ribonuclease H2 subunit C", "type": "recommended", "evidence": [ { "id": "Q2M2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4/entry#names_and_taxonomy" } ] }, { "name": "AYP1 protein", "type": "synonym", "evidence": [ { "id": "NP_001039386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" } ] }, { "name": "RNase H2 subunit C", "type": "synonym", "evidence": [ { "id": "NP_001039386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" }, { "id": "Q2M2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4/entry#names_and_taxonomy" } ] }, { "name": "Ribonuclease HI subunit C", "type": "synonym", "evidence": [ { "id": "Q2M2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease H2 subunit C", "type": "synonym", "evidence": [ { "id": "NP_001039386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" } ] }, { "name": "ribonuclease HI subunit C", "type": "synonym", "evidence": [ { "id": "NP_001039386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386" } ] } ], "function": [ { "annotation": "Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNASEH2C", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4", "locus": { "chromosome": "29", "start_pos": 43886446, "end_pos": 43887621, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005577", "url": "https://www.ensembl.org/id/ENSBTAG00000005577" } ] } } ], "crossref": [ { "id": "Q2M2U4", "url": "https://alphafold.ebi.ac.uk/entry/Q2M2U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005577", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09271", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09271", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505618", "url": "https://www.ncbi.nlm.nih.gov/gene/505618", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013924", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013924", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505618", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505618", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FDQFIGA", "url": "https://omabrowser.org/oma/group/FDQFIGA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2M2U4", "url": "https://www.orthodb.org/?gene=Q2M2U4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47063", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47063", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47063:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47063:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2M2U4-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENSYEETIDKRRVHLRPDTLRDPAPASLHLLPCEVPVNRPTPVGRFFTPAIRMGRDGLEASFRGRSLRGEEVVVPPGFVGYVVTEEKAEVLMGKQDDHERQEQELLEPPEALERDCDRFMGATASFSSFTVWGLESIPGPDAKLRGALSWPSLAAAIHAQVPED", "length": 165, "header": "sp|Q2M2U4-1|RNH2C_BOVIN Isoform 1 of Ribonuclease H2 subunit C OS=Bos taurus OX=9913 GN=RNASEH2C PE=2 SV=1 CANONICAL=Q2M2U4-1" }, "isoforms": [ { "isoform_ac": "Q2M2U4-1", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4/entry#Q2M2U4-1", "sequence": { "sequence": "MENSYEETIDKRRVHLRPDTLRDPAPASLHLLPCEVPVNRPTPVGRFFTPAIRMGRDGLEASFRGRSLRGEEVVVPPGFVGYVVTEEKAEVLMGKQDDHERQEQELLEPPEALERDCDRFMGATASFSSFTVWGLESIPGPDAKLRGALSWPSLAAAIHAQVPED", "length": 165, "header": "sp|Q2M2U4-1|RNH2C_BOVIN Isoform 1 of Ribonuclease H2 subunit C OS=Bos taurus OX=9913 GN=RNASEH2C PE=2 SV=1 CANONICAL=Q2M2U4-1" }, "locus": { "chromosome": "29", "start_pos": 43887579, "end_pos": 43886549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007327.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007327.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007327.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007327.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505618", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505618", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JDW6-1", "protein_name": "Ribonuclease H2 subunit C isoform X1", "gene_name": "Rnaseh2c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MESSDEAADSKQRVHLRPDSLRAAAPATLHLLPCEVQVSRPAPVERFFTPAVRHGVDGLQVSFRGRGLRGEEVAVPPGFSGFVMVTEEMGEGLIGKLNFSGDAEDKTEETQEPLERDFDRFMGATGSFSHFTLWGLETVPGPDAKVHKALGWPSLAAAAHRSTWKLSQNRI", "length": 171 }, "evidence": [ { "id": "Q2M2U4", "url": "https://omabrowser.org/oma/group/Q2M2U4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A434-1", "protein_name": "Ribonuclease H2, subunit C", "gene_name": "Rnaseh2c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKNPEEAGDDKQRIHLRPGSLRGAAPAKLHLLPCDVLVSRPAPVERFFTPAVRHGADGLQVSFRGRGLRGEDVAVPPGFAGFVMVTEEMGEGLIGKLNFSGDAEDKADEAQEPLERDFDRFIGATGSFSHFTLWGLETVPGPDAKVHRALGWPSLAAAIHAQVPED", "length": 166 }, "evidence": [ { "id": "Q2M2U4", "url": "https://omabrowser.org/oma/group/Q2M2U4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RRK5-1", "protein_name": "Ribonuclease H2 subunit C", "gene_name": "RNASEH2C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESSDEESVHRRRVHLRPFTLRSPAPVTLHLLPCEVPVSRPAPVGRFFTPAIRQGPYGLEASFRGRSLRGEEVAVPPGLVGYVMTEEQGEVSVGKQDFSEGSEEDHEVMESPETLERDFDRFIGATASFSSFTLWGLETIPGPDSKVRGALTWPSLAAAIHAQVPED", "length": 167 }, "evidence": [ { "id": "Q2M2U4", "url": "https://omabrowser.org/oma/group/Q2M2U4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8TDP1-1", "protein_name": "Ribonuclease H2 subunit C", "gene_name": "RNASEH2C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED", "length": 164 }, "evidence": [ { "id": "Q2M2U4", "url": "https://omabrowser.org/oma/group/Q2M2U4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQ18-1", "protein_name": "Ribonuclease H2 subunit C", "gene_name": "Rnaseh2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNPEEAADGKQRIHLRPGSLRGAAPAKLHLLPCDVLVSRPAPVDRFFTPAVRHDADGLQASFRGRGLRGEEVAVPPGFAGFVMVTEEKGEGLIGKLNFSGDAEDKADEAQEPLERDFDRLIGATGSFSHFTLWGLETVPGPDAKVHRALGWPSLAAAIHAQVPED", "length": 166 }, "evidence": [ { "id": "Q2M2U4", "url": "https://omabrowser.org/oma/group/Q2M2U4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4" } ], "pmid": "" }, { "name": "ribonuclease H2 complex", "id": "GO:0032299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032299", "evidence": [ { "database": "UniProtKB", "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA catabolic process", "id": "GO:0006401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006401", "evidence": [ { "database": "UniProtKB", "id": "Q2M2U4", "url": "https://www.uniprot.org/uniprotkb/Q2M2U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2M2U4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2M2U4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2M2U4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKR1-1", "uniprot_ac": "Q2NKR1", "uniprot_id": "TIM10_BOVIN", "mass": { "chemical_mass": 10333.0, "monoisotopic_mass": 10333.0 }, "refseq": { "ac": "NP_001039597", "name": "mitochondrial import inner membrane translocase subunit Tim10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039597" }, "gene_names": [ { "name": "TIMM10", "type": "recommended", "evidence": [ { "id": "Q2NKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ] }, { "name": "TIM10", "type": "synonym", "evidence": [ { "id": "Q2NKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ] }, { "name": "TIMM10", "type": "synonym", "evidence": [ { "id": "NP_001039597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039597" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim10", "type": "recommended", "evidence": [ { "id": "Q2NKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim10", "type": "synonym", "evidence": [ { "id": "NP_001039597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039597" } ] }, { "name": "translocase of inner mitochondrial membrane 10 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039597" } ] } ], "function": [ { "annotation": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM10", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1", "locus": { "chromosome": "15", "start_pos": 80788220, "end_pos": 80790815, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024701", "url": "https://www.ensembl.org/id/ENSBTAG00000024701" } ] } } ], "crossref": [ { "id": "Q2NKR1", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024701", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024701", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512818", "url": "https://www.ncbi.nlm.nih.gov/gene/512818", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512818", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512818", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VGENMQK", "url": "https://omabrowser.org/oma/group/VGENMQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKR1", "url": "https://www.orthodb.org/?gene=Q2NKR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11038:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11038:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKR1-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRAQQSSGPV", "length": 90, "header": "sp|Q2NKR1-1|TIM10_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim10 OS=Bos taurus OX=9913 GN=TIMM10 PE=3 SV=1 CANONICAL=Q2NKR1-1" }, "isoforms": [ { "isoform_ac": "Q2NKR1-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1/entry#Q2NKR1-1", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRAQQSSGPV", "length": 90, "header": "sp|Q2NKR1-1|TIM10_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim10 OS=Bos taurus OX=9913 GN=TIMM10 PE=3 SV=1 CANONICAL=Q2NKR1-1" }, "locus": { "chromosome": "15", "start_pos": 80790259, "end_pos": 80788448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034384.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034384.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034279.3", "url": "https://www.ensembl.org/id/ENSBTAP00000034279.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512818", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512818", "resource": "KEGG Pathway" }, { "id": "R-BTA-1268020", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VQG5-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BXY8-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDPLRAQQLAAELEVDMMADMYNRMTQACHLKCVPPHYKEAELSKGESVCLDRCVAKYLDVHERMGKKLTELSLQDEELLKRMQQGTGTA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HRI3-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "Timm10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P62072-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "TIMM10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62073-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "Timm10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62074-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "Timm10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA", "length": 90 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P87108-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM10", "gene_name": "TIM10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF", "length": 93 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6DI06-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "timm10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPMKAQQLAAELEVEMMADMYNRMTNACHRKCVPPHYKEAELSKGEAVCLDRCVAKYLDLHERLGRKLTELSVQDEEVMRKAAAGTG", "length": 88 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9ZW33-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM10", "gene_name": "TIM10", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASPIPVGVTKEQAFSMAQTEMEYRVELFNKLAQTCFNKCVDKRYKEAELNMGENSCIDRCVSKYWQVNGMVGQLLSAGKPPV", "length": 83 }, "evidence": [ { "id": "Q2NKR1", "url": "https://omabrowser.org/oma/group/Q2NKR1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial intermembrane space chaperone complex", "id": "GO:0042719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042719", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" }, { "name": "TIM22 mitochondrial import inner membrane insertion complex", "id": "GO:0042721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042721", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" }, { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 90, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKR1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKR3-1", "uniprot_ac": "Q2NKR3", "uniprot_id": "COXM2_BOVIN", "mass": { "chemical_mass": 9489.0, "monoisotopic_mass": 9489.0 }, "refseq": { "ac": "NP_001106646", "name": "COX assembly mitochondrial protein 2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646" }, "gene_names": [ { "name": "CMC2", "type": "recommended", "evidence": [ { "id": "Q2NKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" } ] }, { "name": "C18H16orf61", "type": "synonym", "evidence": [ { "id": "NP_001106646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646" } ] }, { "name": "CMC2", "type": "synonym", "evidence": [ { "id": "NP_001106646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646" } ] } ], "protein_names": [ { "name": "COX assembly mitochondrial protein 2 homolog", "type": "recommended", "evidence": [ { "id": "Q2NKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3/entry#names_and_taxonomy" } ] }, { "name": "COX assembly mitochondrial protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001106646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646" } ] }, { "name": "uncharacterized protein C16orf61 homolog", "type": "synonym", "evidence": [ { "id": "NP_001106646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646" } ] } ], "function": [ { "annotation": "May be involved in cytochrome c oxidase biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR3", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKR3", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CMC2", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3", "locus": { "chromosome": "7", "start_pos": 79109528, "end_pos": 79108807, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030274", "url": "https://www.ensembl.org/id/ENSBTAG00000030274" } ] } } ], "crossref": [ { "id": "Q2NKR3", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017009", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017009", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614078", "url": "https://www.ncbi.nlm.nih.gov/gene/614078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905951", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905951", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:614078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLRNEYI", "url": "https://omabrowser.org/oma/group/CLRNEYI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKR3", "url": "https://www.orthodb.org/?gene=Q2NKR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22977:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22977:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001106646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106646", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKR3", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKR3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPDLSPHLHTEECNVLINLLKECHKNHSILKFFGHCNDLDREMRKCLKNEYMEKRNKSRELGNAMRKRLFNPPEESEN", "length": 79, "header": "sp|Q2NKR3-1|COXM2_BOVIN Isoform 1 of COX assembly mitochondrial protein 2 homolog OS=Bos taurus OX=9913 GN=CMC2 PE=3 SV=1 CANONICAL=Q2NKR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDE3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3/entry#A0AAA9TDE3-1", "sequence": { "sequence": "MHPDLSPHLHTEECNVLINLLKECHKNYMEKRNKSRELGNAMRKRLFNPPEESEN", "length": 55, "header": "tr|A0AAA9TDE3-1|A0AAA9TDE3_BOVIN Computationally mapped isoform of COX assembly mitochondrial protein OS=Bos taurus OX=9913 GN=CMC2 PE=3 SV=2 CANONICAL=Q2NKR3-1" }, "locus": { "chromosome": "18", "start_pos": 7693223, "end_pos": 7686324, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092398.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092398.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094160.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094160.2" } ] } }, { "isoform_ac": "A0AAF6Z3C2-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3/entry#A0AAF6Z3C2-1", "sequence": { "sequence": "MTELVSRCSAVFHLLLKMHPDLSPHLHTEECNVLINLLKECHKNHSILKFFGHCNDLDREMRKCLKNEYMEKRNKSRELGNAMRKRLFNPPEESEN", "length": 96, "header": "tr|A0AAF6Z3C2-1|A0AAF6Z3C2_BOVIN Computationally mapped isoform of COX assembly mitochondrial protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q2NKR3-1" }, "locus": { "chromosome": "18", "start_pos": 7693223, "end_pos": 7686324, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022619.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022619.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022619.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022619.3" } ] } }, { "isoform_ac": "Q2NKR3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3/entry#Q2NKR3-1", "sequence": { "sequence": "MHPDLSPHLHTEECNVLINLLKECHKNHSILKFFGHCNDLDREMRKCLKNEYMEKRNKSRELGNAMRKRLFNPPEESEN", "length": 79, "header": "sp|Q2NKR3-1|COXM2_BOVIN Isoform 1 of COX assembly mitochondrial protein 2 homolog OS=Bos taurus OX=9913 GN=CMC2 PE=3 SV=1 CANONICAL=Q2NKR3-1" }, "locus": { "chromosome": "7", "start_pos": 79109218, "end_pos": 79108982, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138218.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138218.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106127.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101905951", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905951", "resource": "KEGG Pathway" }, { "id": "bta:614078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614078", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A471-1", "protein_name": "COX assembly mitochondrial protein", "gene_name": "Cmc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHPDLSPHLHTEECNVLINLLKECHKNHNILKFFGHCNDLDREMRKCLKNEYMEKRNRSREHGAAMRSRLSDPPEETGR", "length": 79 }, "evidence": [ { "id": "Q2NKR3", "url": "https://omabrowser.org/oma/group/Q2NKR3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NRP2-1", "protein_name": "COX assembly mitochondrial protein 2 homolog", "gene_name": "CMC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHPDLSPHLHTEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKLFNPPEESEK", "length": 79 }, "evidence": [ { "id": "Q2NKR3", "url": "https://omabrowser.org/oma/group/Q2NKR3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2NKR3", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKR3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 79, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKR3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKR3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 55, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 1", "eco_id": "ECO_0000255", "start_pos": 14, "end_pos": 24, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKR3" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 2", "eco_id": "ECO_0000255", "start_pos": 37, "end_pos": 47, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKS3-1", "uniprot_ac": "Q2NKS3", "uniprot_id": "PSMG3_BOVIN", "mass": { "chemical_mass": 12901.0, "monoisotopic_mass": 12901.0 }, "refseq": { "ac": "NP_001039524", "name": "proteasome assembly chaperone 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039524" }, "gene_names": [ { "name": "PSMG3", "type": "recommended", "evidence": [ { "id": "Q2NKS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ] }, { "name": "PSMG3", "type": "synonym", "evidence": [ { "id": "NP_001039524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039524" } ] } ], "protein_names": [ { "name": "Proteasome assembly chaperone 3", "type": "recommended", "evidence": [ { "id": "Q2NKS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) assembly chaperone 3", "type": "synonym", "evidence": [ { "id": "NP_001039524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039524" } ] }, { "name": "proteasome assembly chaperone 3", "type": "synonym", "evidence": [ { "id": "NP_001039524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039524" } ] } ], "function": [ { "annotation": "Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMG3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3", "locus": { "chromosome": "25", "start_pos": 41387986, "end_pos": 41386821, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000050", "url": "https://www.ensembl.org/id/ENSBTAG00000000050" } ] } } ], "crossref": [ { "id": "Q2NKS3", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000050", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000050", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510741", "url": "https://www.ncbi.nlm.nih.gov/gene/510741", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510741", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510741", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHVCAKN", "url": "https://omabrowser.org/oma/group/IHVCAKN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKS3", "url": "https://www.orthodb.org/?gene=Q2NKS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31051:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31051:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKS3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGKPLLTSKQKTAVVCGVPTQVVCTAFSSHILVVVTQLGKMGTLVSLEPSSVTSDVGKPVLTTKVLLGKDEPLVHVFAKNLVAFVSQEAGNRAVLLALATKDKSMEAVKALQEVIQACQVW", "length": 122, "header": "sp|Q2NKS3-1|PSMG3_BOVIN Isoform 1 of Proteasome assembly chaperone 3 OS=Bos taurus OX=9913 GN=PSMG3 PE=2 SV=1 CANONICAL=Q2NKS3-1" }, "isoforms": [ { "isoform_ac": "Q2NKS3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3/entry#Q2NKS3-1", "sequence": { "sequence": "MEGKPLLTSKQKTAVVCGVPTQVVCTAFSSHILVVVTQLGKMGTLVSLEPSSVTSDVGKPVLTTKVLLGKDEPLVHVFAKNLVAFVSQEAGNRAVLLALATKDKSMEAVKALQEVIQACQVW", "length": 122, "header": "sp|Q2NKS3-1|PSMG3_BOVIN Isoform 1 of Proteasome assembly chaperone 3 OS=Bos taurus OX=9913 GN=PSMG3 PE=2 SV=1 CANONICAL=Q2NKS3-1" }, "locus": { "chromosome": "25", "start_pos": 41387678, "end_pos": 41386855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000055.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000055.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000055.2", "url": "https://www.ensembl.org/id/ENSBTAP00000000055.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510741", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510741", "resource": "KEGG Pathway" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZIU2-1", "protein_name": "Proteasome assembly chaperone 3", "gene_name": "Psmg3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDKPLVVSKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSNVANDISKPVLTTKVLLGQDEPLIHVFAKNLVAFVSEEAGDRAVLLAMAVKEKNMERLKALKEVIRLCQVW", "length": 122 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RIW5-1", "protein_name": "Proteasome assembly chaperone 3", "gene_name": "PSMG3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGKPLVMSKQTTAVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLESSSMTSDISKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLALAVKDKSMEGVTALKEVIRTCQVW", "length": 122 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GVG0-1", "protein_name": "Proteasome assembly chaperone 3", "gene_name": "Psmg3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDKPLVFSKQKTEVVCGVPTQVICTAFSSHILVVVTQFGKMGTLVSLEPSSVANDISKPVLTTKVLLGQDEPLIHVFAKNLVSFVSQEAGNRAVLLAMAVKDKSMEGLKALKEVIRTCQVW", "length": 122 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9BT73-1", "protein_name": "Proteasome assembly chaperone 3", "gene_name": "PSMG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQVW", "length": 122 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZH3-1", "protein_name": "Proteasome assembly chaperone 3", "gene_name": "Psmg3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDKPLVVSKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSNVANDISKPVLTTRVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAMAVKDKSMERLKALKEVIRLCQVW", "length": 122 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LER5-1", "protein_name": "Proteasome assembly chaperone-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MESLDTNFPVRHRKVSFESKGNKTEIVICSYEDHILIIATQIGAMGTILHARKEEGMSVEPTFSVSVIFGKRDEPMLTATARRLIEHISSIVPSKPLVLSLGLKDHSSETLKEIVATVIENRLW", "length": 124 }, "evidence": [ { "id": "Q2NKS3", "url": "https://omabrowser.org/oma/group/Q2NKS3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome assembly", "id": "GO:0043248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043248", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "pmid": "" }, { "name": "chaperone-mediated protein complex assembly", "id": "GO:0051131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051131", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q2NKS3", "url": "https://www.uniprot.org/uniprotkb/Q2NKS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 122, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKS3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKT1-1", "uniprot_ac": "Q2NKT1", "uniprot_id": "PROF4_BOVIN", "mass": { "chemical_mass": 14492.0, "monoisotopic_mass": 14492.0 }, "refseq": { "ac": "NP_001068845", "name": "profilin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068845" }, "gene_names": [ { "name": "PFN4", "type": "recommended", "evidence": [ { "id": "Q2NKT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ] }, { "name": "PFN4", "type": "synonym", "evidence": [ { "id": "NP_001068845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068845" } ] } ], "protein_names": [ { "name": "Profilin-4", "type": "recommended", "evidence": [ { "id": "Q2NKT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1/entry#names_and_taxonomy" } ] }, { "name": "profilin IV", "type": "synonym", "evidence": [ { "id": "NP_001068845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068845" } ] }, { "name": "profilin-4", "type": "synonym", "evidence": [ { "id": "NP_001068845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068845" } ] } ], "function": [ { "annotation": "Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1#function" }, { "database": "UniProtKB", "id": "Q8NHR9", "url": "https://www.uniprot.org/uniprotkb/Q8NHR9#function" }, { "database": "UniProtKB", "id": "Q9D6I3", "url": "https://www.uniprot.org/uniprotkb/Q9D6I3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFN4", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1", "locus": { "chromosome": "11", "start_pos": 74978079, "end_pos": 74974219, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003404", "url": "https://www.ensembl.org/id/ENSBTAG00000003404" } ] } } ], "crossref": [ { "id": "Q2NKT1", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKT1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003404", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003404", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508874", "url": "https://www.ncbi.nlm.nih.gov/gene/508874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508874", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508874", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGQKFML", "url": "https://omabrowser.org/oma/group/QGQKFML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKT1", "url": "https://www.orthodb.org/?gene=Q2NKT1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11604", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11604", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11604:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11604:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00235", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00235", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068845", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKT1-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDSAALIKLQERSLCVASPGFSVMPSDVRTLVNGFAKNPLKTRREGLYFKEKDYKCVRADDYSLYAKNENTGVIVVKTHLYLLVATYSEGMYPSVCVEATEKLGDYLRRKGN", "length": 129, "header": "sp|Q2NKT1-1|PROF4_BOVIN Isoform 1 of Profilin-4 OS=Bos taurus OX=9913 GN=PFN4 PE=2 SV=1 CANONICAL=Q2NKT1-1" }, "isoforms": [ { "isoform_ac": "Q2NKT1-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1/entry#Q2NKT1-1", "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDSAALIKLQERSLCVASPGFSVMPSDVRTLVNGFAKNPLKTRREGLYFKEKDYKCVRADDYSLYAKNENTGVIVVKTHLYLLVATYSEGMYPSVCVEATEKLGDYLRRKGN", "length": 129, "header": "sp|Q2NKT1-1|PROF4_BOVIN Isoform 1 of Profilin-4 OS=Bos taurus OX=9913 GN=PFN4 PE=2 SV=1 CANONICAL=Q2NKT1-1" }, "locus": { "chromosome": "11", "start_pos": 74978018, "end_pos": 74975414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004412.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004412.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004412.2", "url": "https://www.ensembl.org/id/ENSBTAP00000004412.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508874", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508874", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HWX0-1", "protein_name": "Profilin", "gene_name": "Pfn4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDGAALIKLHERSLCVASPGFSVMPNDVRTLVNGFAKNPLITRREGLYFREKDYKCVRADDYSLYAKNENTGVIVVKTHLYLLVATYTAGMYPSVCVEATEKLGEYLRKKGN", "length": 129 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1TZQ3-1", "protein_name": "Profilin", "gene_name": "PFN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDCAALIKLQERSLCVASPGFSVMPSDIRTLVNVFAKNPLKARREGLYFKEKDYKCVRADDYSLYAKNENTGVVVVKTHLYLLVATYTNGMYPSVCVEATEKLGEYLRRKGN", "length": 129 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P07274-1", "protein_name": "Profilin", "gene_name": "PFY1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSWQAYTDNLIGTGKVDKAVIYSRAGDAVWATSGGLSLQPNEIGEIVQGFDNPAGLQSNGLHIQGQKFMLLRADDRSIYGRHDAEGVVCVRTKQTVIIAHYPPTVQAGEATKIVEQLADYLIGVQY", "length": 126 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P26199-1", "protein_name": "Profilin-1", "gene_name": "proA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSWQQYVDEQLTGAGLSQGAILGANDGGVWAKSSGINITKPEGDGIAALFKNPAEVFAKGALIGGVKYMGIKGDPQSIYGKKGATGCVLVRTGQAIIVGIYDDKVQPGSAALIVEKLGDYLRDNGY", "length": 126 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5IRJ7-1", "protein_name": "Profilin-4", "gene_name": "Pfn4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDGAALIKLQEKTLCVTSPGFSVMPCDVRTLLNGFAKNPLLTRREGLYFREKDYKCVRADDCSLYAKKENTGVVVVKTHMYLLVATYTAGMYPSVCVEATEKLGEYLRKKGN", "length": 129 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NHR9-1", "protein_name": "Profilin-4", "gene_name": "PFN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHLQSLLLDTLLGTKHVDSAALIKIQERSLCVASPGFNVTPSDVRTLVNGFAKNPLQARREGLYFKGKDYRCVRADEYSLYAKNENTGVVVVKTHLYLLVATYTEGMYPSICVEATESLGDYLRKKGS", "length": 129 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6I3-1", "protein_name": "Profilin-4", "gene_name": "Pfn4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHLQNLLLDTLLGTKHVDSAALIKLQEKTLCVTSPGFSVMPSDVRTLLNGFAKNPLLTRREGLYFKEKDYKCVRADDYSLYAKNENTGVVVVKTNMYLVVATYTAGMYPSVCVEATEKLGEYLRKKGN", "length": 129 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "X1WCU6-1", "protein_name": "Profilin", "gene_name": "pfn4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNPLPKLLEDCLISTKHVERAAVFVAKTCDITAASNFTVCLEEIQIFLDAFKHLNETMKKGLIFRDKPYTCVRADKHSIYAKNEGRGLILVRTALYVIVATYSQTMHPSICVEAVEKLGDYLREKGK", "length": 127 }, "evidence": [ { "id": "Q2NKT1", "url": "https://omabrowser.org/oma/group/Q2NKT1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" }, { "name": "manchette assembly", "id": "GO:1905198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905198", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" }, { "name": "sperm flagellum assembly", "id": "GO:0120316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120316", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT1", "url": "https://www.uniprot.org/uniprotkb/Q2NKT1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKT1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 129, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKT1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKT1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKV2-1", "uniprot_ac": "Q2NKV2", "uniprot_id": "APC13_BOVIN", "mass": { "chemical_mass": 8521.0, "monoisotopic_mass": 8521.0 }, "refseq": { "ac": "NP_001106700", "name": "anaphase-promoting complex subunit 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" }, "gene_names": [ { "name": "ANAPC13", "type": "recommended", "evidence": [ { "id": "Q2NKV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ] }, { "name": "ANAPC13", "type": "synonym", "evidence": [ { "id": "NP_001106700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit 13", "type": "recommended", "evidence": [ { "id": "Q2NKV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2/entry#names_and_taxonomy" } ] }, { "name": "APC13", "type": "synonym", "evidence": [ { "id": "NP_001106700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" }, { "id": "Q2NKV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2/entry#names_and_taxonomy" } ] }, { "name": "Cyclosome subunit 13", "type": "synonym", "evidence": [ { "id": "Q2NKV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2/entry#names_and_taxonomy" } ] }, { "name": "anaphase-promoting complex subunit 13", "type": "synonym", "evidence": [ { "id": "NP_001106700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" } ] }, { "name": "cyclosome subunit 13", "type": "synonym", "evidence": [ { "id": "NP_001106700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" } ] }, { "name": "cylosome subunit 13", "type": "synonym", "evidence": [ { "id": "NP_001106700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2#function" }, { "database": "UniProtKB", "id": "Q9BS18", "url": "https://www.uniprot.org/uniprotkb/Q9BS18#function" } ] }, { "annotation": "Polymorphisms and mutations in non-coding regions of the ANAPC13 gene significantly affect body measurement traits. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001106700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" }, { "database": "PubMed", "id": "22782628", "url": "https://glygen.org/publication/PubMed/22782628" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANAPC13", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2", "locus": { "chromosome": "1", "start_pos": 134845010, "end_pos": 134837731, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014461", "url": "https://www.ensembl.org/id/ENSBTAG00000014461" } ] } } ], "crossref": [ { "id": "Q2NKV2", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614347", "url": "https://www.ncbi.nlm.nih.gov/gene/614347", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "5A31", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5A31&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "5G05", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5G05&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR008401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614347", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614347", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHDDIAV", "url": "https://omabrowser.org/oma/group/PHDDIAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKV2", "url": "https://www.orthodb.org/?gene=Q2NKV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28672", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28672", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28672:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28672:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00005a31", "url": "https://www.rcsb.org/structure/pdb_00005a31", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00005g05", "url": "https://www.rcsb.org/structure/pdb_00005g05", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A31", "url": "https://www.rcsb.org/structure/5A31", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5G05", "url": "https://www.rcsb.org/structure/5G05", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKV2-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN", "length": 74, "header": "sp|Q2NKV2-1|APC13_BOVIN Isoform 1 of Anaphase-promoting complex subunit 13 OS=Bos taurus OX=9913 GN=ANAPC13 PE=1 SV=1 CANONICAL=Q2NKV2-1" }, "isoforms": [ { "isoform_ac": "Q2NKV2-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2/entry#Q2NKV2-1", "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN", "length": 74, "header": "sp|Q2NKV2-1|APC13_BOVIN Isoform 1 of Anaphase-promoting complex subunit 13 OS=Bos taurus OX=9913 GN=ANAPC13 PE=1 SV=1 CANONICAL=Q2NKV2-1" }, "locus": { "chromosome": "1", "start_pos": 134844455, "end_pos": 134840472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019228.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019228.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019228.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019228.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of ANAPC13 gene polymorphisms associated with body measurement traits in Bos taurus.", "journal": "Genetics and molecular research : GMR", "date": "2012-08-29", "authors": "Jiang B J, Zhan X L, Fu C Z, Wang H B, Cheng G, Zan L S", "evidence": [ { "database": "RefSeq", "id": "NP_001106700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106700" } ], "reference": [ { "type": "PubMed", "id": "22782628", "url": "https://glygen.org/publication/PubMed/22782628" } ] } ], "pathway": [ { "id": "bta:614347", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614347", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A427-1", "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "Anapc13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLSELPEPEQDNGGTTESVKEQEMKWTDLALQGLHENVPPTGN", "length": 74 }, "evidence": [ { "id": "Q2NKV2", "url": "https://omabrowser.org/oma/group/Q2NKV2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FFM7-1", "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "anapc13", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSEVQRDGRVLDLTDDAWREDRLPYEDVTIPLSELPEAEQDNGGSTESVKEQEMKWSDLALQSLHENTPNVGT", "length": 74 }, "evidence": [ { "id": "Q2NKV2", "url": "https://omabrowser.org/oma/group/Q2NKV2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HD29-1", "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "Anapc13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLSELPEPEQDNGGTTESVKEQEMKWTDLALQCLHENVPPAGN", "length": 74 }, "evidence": [ { "id": "Q2NKV2", "url": "https://omabrowser.org/oma/group/Q2NKV2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8R034-1", "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "Anapc13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLSELPEPEQDNGGTTESVKEQEMKWTDLALQGLHENVPPAGN", "length": 74 }, "evidence": [ { "id": "Q2NKV2", "url": "https://omabrowser.org/oma/group/Q2NKV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BS18-1", "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "ANAPC13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN", "length": 74 }, "evidence": [ { "id": "Q2NKV2", "url": "https://omabrowser.org/oma/group/Q2NKV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "anaphase-promoting complex", "id": "GO:0005680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV2", "url": "https://www.uniprot.org/uniprotkb/Q2NKV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 74, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKV2" }, { "pdb_id": "5g05", "pdb_chain": "m", "start_pos": 1, "end_pos": 74, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/5g05.pdb", "url_external": "https://www.rcsb.org/structure/5g05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2NKV8-1", "uniprot_ac": "Q2NKV8", "uniprot_id": "GOT1A_BOVIN", "mass": { "chemical_mass": 14817.0, "monoisotopic_mass": 14817.0 }, "refseq": { "ac": "NP_001068829", "name": "vesicle transport protein GOT1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068829" }, "gene_names": [ { "name": "GOLT1A", "type": "recommended", "evidence": [ { "id": "Q2NKV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ] }, { "name": "GOLT1A", "type": "synonym", "evidence": [ { "id": "NP_001068829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068829" } ] } ], "protein_names": [ { "name": "Vesicle transport protein GOT1A", "type": "recommended", "evidence": [ { "id": "Q2NKV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8/entry#names_and_taxonomy" } ] }, { "name": "Golgi transport 1 homolog A", "type": "synonym", "evidence": [ { "id": "Q2NKV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8/entry#names_and_taxonomy" } ] }, { "name": "vesicle transport protein GOT1A", "type": "synonym", "evidence": [ { "id": "NP_001068829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068829" } ] } ], "function": [ { "annotation": "May be involved in fusion of ER-derived transport vesicles with the Golgi complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8#function" }, { "database": "UniProtKB", "id": "Q9Y3E0", "url": "https://www.uniprot.org/uniprotkb/Q9Y3E0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLT1A", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8", "locus": { "chromosome": "16", "start_pos": 1964614, "end_pos": 1968444, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010177", "url": "https://www.ensembl.org/id/ENSBTAG00000010177" } ] } } ], "crossref": [ { "id": "Q2NKV8", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKV8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508464", "url": "https://www.ncbi.nlm.nih.gov/gene/508464", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508464", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508464", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FFFQRPK", "url": "https://omabrowser.org/oma/group/FFFQRPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKV8", "url": "https://www.orthodb.org/?gene=Q2NKV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21493:SF245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21493:SF245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKV8-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISITEWQKIGVGTTGFGIFFILFGMLLYFDSVLLAFGNLLFLTGLSLIIGLRRTFSFFFQRHKFKGTSFFLGGVVIVLLRWPLLGMCLETYGFFSLFRGFFPVAFGFLGSASNIPFLSALFQRLQGTSSMV", "length": 132, "header": "sp|Q2NKV8-1|GOT1A_BOVIN Isoform 1 of Vesicle transport protein GOT1A OS=Bos taurus OX=9913 GN=GOLT1A PE=2 SV=1 CANONICAL=Q2NKV8-1" }, "isoforms": [ { "isoform_ac": "Q2NKV8-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8/entry#Q2NKV8-1", "sequence": { "sequence": "MISITEWQKIGVGTTGFGIFFILFGMLLYFDSVLLAFGNLLFLTGLSLIIGLRRTFSFFFQRHKFKGTSFFLGGVVIVLLRWPLLGMCLETYGFFSLFRGFFPVAFGFLGSASNIPFLSALFQRLQGTSSMV", "length": 132, "header": "sp|Q2NKV8-1|GOT1A_BOVIN Isoform 1 of Vesicle transport protein GOT1A OS=Bos taurus OX=9913 GN=GOLT1A PE=2 SV=1 CANONICAL=Q2NKV8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508464", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508464", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1ABG2-1", "protein_name": "Golgi transport 1A", "gene_name": "GOLT1A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MICRMTWGLKGFPRVTAGKRPTRRAVGQNGDSERLPDPSSAGIGVGLVGFGIFFILFGMLLYFDSVLLAFGNILFLSGLVFIIGFRRTFTFFFQRQKMKGSSFFLGGVLIVLMRWPLLGMLLEAYGFITLFRSAWTHTAPSVPPASATAGLTEPFVSVQEFFPRGFRLFGLTGEYPHSEEGEQGAGQGGHLWMWSLGDRNCWHCWIKAASWACRRRSAWPPCSSWTIVLLIRNGSSCSSWRNWVTAAP", "length": 248 }, "evidence": [ { "id": "Q2NKV8", "url": "https://omabrowser.org/oma/group/Q2NKV8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZFB0-1", "protein_name": "Golgi transport 1A", "gene_name": "Golt1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIGVGITGFGVFFILFGILLYFDSVLLAFGNLLFLTGLSLIIGLRRTFSFFFQRHKLKGTSFFLGGVAIVLLRWPLLGMLLEAYGFVSLFKGFFPVVFGFLGNAFNIPFLSALFQRLQGSSSSMV", "length": 126 }, "evidence": [ { "id": "Q2NKV8", "url": "https://omabrowser.org/oma/group/Q2NKV8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S377-1", "protein_name": "KiSS-1 metastasis suppressor", "gene_name": "GOLT1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MISITEWQKIGVGTTGFGIFFILFGMLLYFDSVLLAFGNLLFLTGLSLIIGLRKTFSFFFQRHKLKGTSFFLGGVLVVLLRWPLLGMCLETYGFFSLFKGFFPVAFGFLGNTSNIPFLSALFRRLQGTSSMV", "length": 132 }, "evidence": [ { "id": "Q2NKV8", "url": "https://omabrowser.org/oma/group/Q2NKV8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6ZVE7-1", "protein_name": "Vesicle transport protein GOT1A", "gene_name": "GOLT1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MISITEWQKIGVGITGFGIFFILFGTLLYFDSVLLAFGNLLFLTGLSLIIGLRKTFWFFFQRHKLKGTSFLLGGVVIVLLRWPLLGMFLETYGFFSLFKGFFPVAFGFLGNVCNIPFLGALFRRLQGTSSMV", "length": 132 }, "evidence": [ { "id": "Q2NKV8", "url": "https://omabrowser.org/oma/group/Q2NKV8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCQ3-1", "protein_name": "Vesicle transport protein GOT1A", "gene_name": "Golt1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MISITEWQKIGVGITGFGVFFILFGILLYFDSVLLAFGNLLFLTGLSLIIGLRRTFAFFFQRHKLKGTSFFLGGVAIVLLRWPLLGMLLEAYGFISLFKGFFPVVFGFLGSAFNIPFLSTLFQKLQGSSSSMV", "length": 133 }, "evidence": [ { "id": "Q2NKV8", "url": "https://omabrowser.org/oma/group/Q2NKV8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "Q2NKV8", "url": "https://www.uniprot.org/uniprotkb/Q2NKV8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKV8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 132, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKV8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKV8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKZ5-1", "uniprot_ac": "Q2NKZ5", "uniprot_id": "CST15_BOVIN", "mass": { "chemical_mass": 14955.0, "monoisotopic_mass": 14955.0 }, "refseq": { "ac": "NP_001071543", "name": "probable cystatin-15 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071543" }, "gene_names": [ { "name": "LOC617402", "type": "synonym", "evidence": [ { "id": "NP_001071543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071543" } ] } ], "protein_names": [ { "name": "Probable cystatin-15", "type": "recommended", "evidence": [ { "id": "Q2NKZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5/entry#names_and_taxonomy" } ] }, { "name": "probable cystatin-15 precursor", "type": "synonym", "evidence": [ { "id": "NP_001071543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071543" } ] }, { "name": "probable cystatin-15", "type": "synonym", "evidence": [ { "id": "NP_001071543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071543" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ5", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5", "locus": {} } ], "crossref": [ { "id": "Q2NKZ5", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027420", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027420", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617402", "url": "https://www.ncbi.nlm.nih.gov/gene/617402", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617402", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617402", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCVERSW", "url": "https://omabrowser.org/oma/group/TCVERSW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKZ5", "url": "https://www.orthodb.org/?gene=Q2NKZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NKZ5", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFWKLPLLLGLLALGPHVCSWMFEDIGKTGQEFSMCVEFAIHHFNEHQPDENAYKLLWVRRSQHKKFSLTYLMDLHLGRTICKKHDEDIDNCPLQEGPEGKKVNCTFIVDSRPLYTKFTLLNSTCQQI", "length": 128, "header": "sp|Q2NKZ5-1|CST15_BOVIN Isoform 1 of Probable cystatin-15 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2NKZ5-1" }, "isoforms": [ { "isoform_ac": "Q2NKZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5/entry#Q2NKZ5-1", "sequence": { "sequence": "MFWKLPLLLGLLALGPHVCSWMFEDIGKTGQEFSMCVEFAIHHFNEHQPDENAYKLLWVRRSQHKKFSLTYLMDLHLGRTICKKHDEDIDNCPLQEGPEGKKVNCTFIVDSRPLYTKFTLLNSTCQQI", "length": 128, "header": "sp|Q2NKZ5-1|CST15_BOVIN Isoform 1 of Probable cystatin-15 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q2NKZ5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 104, "start_aa": "Asn", "end_pos": 104, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn104", "evidence": [ { "id": "Q2NKZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617402", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617402", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SAT1-1", "protein_name": "Cystatin domain-containing protein", "gene_name": "LOC100515765", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPKVPLFLGVLLLGPHVCSWNFENVSKTMDYFSICVEFAVFHFNQHQPDEYAYKLLWVGRSQRKKFTWIYLMDLKLGRTICKKHDEDIDNCPLQEGPEKKTAKCTFIVDVRPWYTQFNLLNSTCEQK", "length": 128 }, "evidence": [ { "id": "Q2NKZ5", "url": "https://omabrowser.org/oma/group/Q2NKZ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VII2-1", "protein_name": "Cystatin-12", "gene_name": "Cst12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWKSVLPVALIVLGIHDCSFKFIEIDKNEEEFAMSMEHVLFHFNENQNDDFAYKFLRVRRSLRKKYTQKYLVDLEMGRTLCGKYDEDIDNCPLQEGPGEKKVRCTYIVETRVWVTEFTILNSTCVQT", "length": 128 }, "evidence": [ { "id": "Q2NKZ5", "url": "https://omabrowser.org/oma/group/Q2NKZ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DAN8-1", "protein_name": "Cystatin-12", "gene_name": "Cst12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLWKSVLSVALIVLGIHDCSFKFLEIDKNEEEFAISVEHVVFHFNENQDDDFAYKFLRVRRSLRQKYTLKYLVDLEMGRTLCGKYDEDIDNCPLQEGPGERKVRCTYIVETEAWVTKFTILNSTCVQT", "length": 128 }, "evidence": [ { "id": "Q2NKZ5", "url": "https://omabrowser.org/oma/group/Q2NKZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ5", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ5", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKZ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 104 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 122, "end_pos": 124 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL01-1", "uniprot_ac": "Q2NL01", "uniprot_id": "GPX8_BOVIN", "mass": { "chemical_mass": 23983.0, "monoisotopic_mass": 23983.0 }, "refseq": { "ac": "NP_001039553", "name": "probable glutathione peroxidase 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553" }, "gene_names": [ { "name": "GPX8", "type": "recommended", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ] }, { "name": "GPX8", "type": "synonym", "evidence": [ { "id": "NP_001039553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553" } ] } ], "protein_names": [ { "name": "Protein peroxidase GPX8", "type": "recommended", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#names_and_taxonomy" } ] }, { "name": "5.3.4.1", "type": "synonym", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#names_and_taxonomy" } ] }, { "name": "GPx-8", "type": "synonym", "evidence": [ { "id": "NP_001039553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553" }, { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#names_and_taxonomy" } ] }, { "name": "GSHPx-8", "type": "synonym", "evidence": [ { "id": "NP_001039553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553" }, { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#names_and_taxonomy" } ] }, { "name": "probable glutathione peroxidase 8", "type": "synonym", "evidence": [ { "id": "NP_001039553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553" } ] } ], "function": [ { "annotation": "Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage.", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01#function" }, { "database": "UniProtKB", "id": "Q8TED1", "url": "https://www.uniprot.org/uniprotkb/Q8TED1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPX8", "url": "https://www.uniprot.org/uniprotkb/Q2NL01", "locus": { "chromosome": "20", "start_pos": 23951563, "end_pos": 23956371, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021960", "url": "https://www.ensembl.org/id/ENSBTAG00000021960" } ] } } ], "crossref": [ { "id": "Q2NL01", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021960", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021960", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511575", "url": "https://www.ncbi.nlm.nih.gov/gene/511575", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511575", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511575", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTWNFCK", "url": "https://omabrowser.org/oma/group/PTWNFCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL01", "url": "https://www.orthodb.org/?gene=Q2NL01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3299685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039553", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Q9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL01-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPLTAYPLRCSGPKAKAFAVLLSMVLCTVMLFLLQLKFLKPKINSFYTFEVKDANGRVVSLEKFKGKVALVVNVASDCQLTDRNYLALQELHKEFGPFHFSVLAFPCNQFGESEPRPSKEVVSFARNNFGVTFPIFHKIKILGSEAEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKTWRPEEPIEVIRPEIAALIRQMIIKKKEDL", "length": 209, "header": "sp|Q2NL01-1|GPX8_BOVIN Isoform 1 of Protein peroxidase GPX8 OS=Bos taurus OX=9913 GN=GPX8 PE=2 SV=1 CANONICAL=Q2NL01-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P0Q9-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#A0ABI0P0Q9-1", "sequence": { "sequence": "MEPLTAYPLRCSGPKAKAFAVLLSMVLCTVMLFLLQLKFLKPKINSFYTFEVKDANGRVVSLEKFKGKILQRRNQGGTFGSIWSTLKVKL", "length": 90, "header": "tr|A0ABI0P0Q9-1|A0ABI0P0Q9_BOVIN Computationally mapped isoform of Glutathione peroxidase 8 (putative) OS=Bos taurus OX=9913 GN=GPX8 PE=4 SV=1 CANONICAL=Q2NL01-1" }, "locus": { "chromosome": "20", "start_pos": 23956347, "end_pos": 23952092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136350.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136350.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106224.1" } ] } }, { "isoform_ac": "Q2NL01-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL01/entry#Q2NL01-1", "sequence": { "sequence": "MEPLTAYPLRCSGPKAKAFAVLLSMVLCTVMLFLLQLKFLKPKINSFYTFEVKDANGRVVSLEKFKGKVALVVNVASDCQLTDRNYLALQELHKEFGPFHFSVLAFPCNQFGESEPRPSKEVVSFARNNFGVTFPIFHKIKILGSEAEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKTWRPEEPIEVIRPEIAALIRQMIIKKKEDL", "length": 209, "header": "sp|Q2NL01-1|GPX8_BOVIN Isoform 1 of Protein peroxidase GPX8 OS=Bos taurus OX=9913 GN=GPX8 PE=2 SV=1 CANONICAL=Q2NL01-1" }, "locus": { "chromosome": "20", "start_pos": 23956347, "end_pos": 23951997, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029279.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029279.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029279.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029279.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511575", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511575", "resource": "KEGG Pathway" }, { "id": "R-BTA-3299685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "resource": "Reactome", "description": "Detoxification of Reactive Oxygen Species" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JGT2-1", "protein_name": "Glutathione peroxidase", "gene_name": "Gpx8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPFAAYPLKCSGSKAKVFAVLLSMVLCTVMLFLLQLKFLKPRINSFYSFEVKDAKGKIVSLEKFKGKEASLVVNVASDCRYTDKSYLTLKELHKEFGPYHFNVLAFPCNQFGESEPRSSTEVESFARRNYGVTFPIFHKIKILGPEAEPAFRFLVDSSKKEPMWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMVGQMILKKKEDL", "length": 210 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZPW7-1", "protein_name": "Glutathione peroxidase", "gene_name": "Gpx8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPLGAYPLKCSGPKAKIFAVLLSMVLCTVMLFLLQLKFLKPRINSFYSFEVKDAKGRMVSLEKFKGKASLVVNVASDCRFTDKSYETLRELHKEFGPYHFNVLAFPCNQFGESEPKSSKEVESFARKNYGVTFPIFHKIKILGPEAEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMIGQIILKKKEDL", "length": 209 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P36014-1", "protein_name": "Glutathione peroxidase-like peroxiredoxin 1", "gene_name": "GPX1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIVAFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGIKMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI", "length": 167 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8L910-1", "protein_name": "Probable glutathione peroxidase 4", "gene_name": "GPX4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGASASVPERSVHQFTVKDSSGKDLNMSIYQGKVLLIVNVASKCGFTETNYTQLTELYRKYKDQDFEILAFPCNQFLYQEPGTSQEAHEFACERFKAEYPVFQKVRVNGQNAAPIYKFLKASKPTFLGSRIKWNFTKFLVGKDGLVIDRYGTMVTPLSIEKDIKKALEDA", "length": 170 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8TED1-1", "protein_name": "Protein peroxidase GPX8", "gene_name": "GPX8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL", "length": 209 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7B7-1", "protein_name": "Protein peroxidase GPX8", "gene_name": "Gpx8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPFAAYPLKCSGPKAKIFAVLLSMVLCTVMLFLLQLKFLKPRTNSFYSFEVKDAKGRTVSLEKFKGKASLVVNVASDCRFTDKSYQTLRELHKEFGPYHFNVLAFPCNQFGESEPKSSKEVESFARQNYGVTFPIFHKIKILGPEAEPAFRFIVDSSKKEPRWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMIGQIILKKKEDL", "length": 209 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "R4GGB2-1", "protein_name": "Glutathione peroxidase", "gene_name": "GPX8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPLTAAYPLKYSVPKARVFVVFLSMVFCTAVLCLLQLRFFKPKTKDFYSFEIKDSRGRIVSLEKYRGKATLVVNVASYCQHTDKNYIALQDLHREFGPSHFTVLAFPCNQFGESEPGSSQEIEAFAKGNYGVTFPVFHKIKILGSEAEPAFKFLIDSSKKEPRWNFWKYLVSPEGKVVKFWRPEEPIESIKPEIASLIRQIIMKKREDL", "length": 210 }, "evidence": [ { "id": "Q2NL01", "url": "https://omabrowser.org/oma/group/Q2NL01/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peroxidase activity", "id": "GO:0004601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "pmid": "" }, { "name": "glutathione peroxidase activity", "id": "GO:0004602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", "evidence": [ { "database": "UniProtKB", "id": "Q2NL01", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-3341296", "name": "GPX7,8 catalyze peroxidation of P4HB (PDI)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [ "R-ALL-3341383", "R-BTA-174692" ], "output_participant_list": [], "enzyme_list": [ "Q2NL01-1", "A5PJN2-1", "F6Q9Q9-1", "A6QLY2-1" ], "evidence": [ { "id": "R-BTA-3341296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3341296" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-3341383", "participant_name": "H2O2 [endoplasmic reticulum lumen]", "crossref": [ { "id": "16240", "database": "ChEBI", "url": "" }, { "id": "C00027", "database": "COMPOUND", "url": "" }, { "id": "11533079", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003125", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-BTA-174692", "participant_name": "P4HB [endoplasmic reticulum lumen]", "crossref": [ { "id": "F6Q9Q9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006045", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000007943", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000007943", "database": "ENSEMBL", "url": "" }, { "id": "32538", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A5PJN2", "gene_name": "ERO1A", "activity": [ { "ec_number": "1.8.3.2", "activity": "2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.", "evidence": [ { "id": "A5PJN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJN2" } ] }, { "ec_number": "1.8.3.2", "activity": "", "evidence": [ { "id": "A5PJN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJN2" } ] } ] }, { "uniprot_ac": "A6QLY2", "gene_name": "GPX7", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ] } ] }, { "uniprot_ac": "F6Q9Q9", "gene_name": "P4HB", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] } ] }, { "uniprot_ac": "Q2NL01", "gene_name": "GPX8", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 209, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL01" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.3.4.1", "ec_name": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "5.3.4.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.4.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2Q0J1-1", "uniprot_ac": "Q2Q0J1", "uniprot_id": "OOSP1_BOVIN", "mass": { "chemical_mass": 18506.0, "monoisotopic_mass": 18506.0 }, "refseq": { "ac": "NP_001033776", "name": "oocyte-secreted protein 1 precursor", "summary": "This gene encodes a secreted protein that is exclusively expressed in oocytes. Multiple transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" }, "gene_names": [ { "name": "OOSP1", "type": "recommended", "evidence": [ { "id": "Q2Q0J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1" } ] }, { "name": "OOSP1", "type": "synonym", "evidence": [ { "id": "NP_001033776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] }, { "name": "OOSP2", "type": "synonym", "evidence": [ { "id": "NP_001033776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] } ], "protein_names": [ { "name": "Oocyte-secreted protein 1", "type": "recommended", "evidence": [ { "id": "Q2Q0J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1/entry#names_and_taxonomy" } ] }, { "name": "oocyte secreted protein 1 (pseudogene)", "type": "synonym", "evidence": [ { "id": "NP_001033776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] }, { "name": "oocyte-secreted protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] }, { "name": "oocyte-secreted protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] } ], "function": [ { "annotation": "May be involved in cell differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q2Q0J1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1#function" } ] }, { "annotation": "This gene encodes a secreted protein that is exclusively expressed in oocytes. Multiple transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001033776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2Q0J1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OOSP1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1", "locus": {} } ], "crossref": [ { "id": "Q2Q0J1", "url": "https://alphafold.ebi.ac.uk/entry/Q2Q0J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616216", "url": "https://www.ncbi.nlm.nih.gov/gene/616216", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616216", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616216", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IWTCAED", "url": "https://omabrowser.org/oma/group/IWTCAED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2Q0J1", "url": "https://www.orthodb.org/?gene=Q2Q0J1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14380:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14380:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001033776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033776", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2Q0J1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2Q0J1-1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2Q0J1-2", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPSSGLRGLLVLFSLTWTCAGDWSAVKVRCSYFWFYAKIKPTLFHNLYMNPDEAFLGNDCPVTYVSPDAHYEFFYYSNKCGIITKTFQETLLLQTKIKYMSSNSGDTAEMPVSCVVTQQACMYHLSNETESGDDETSSEDMEVSYIMQSQNDLNTTFSLCAK", "length": 163, "header": "sp|Q2Q0J1-1|OOSP1_BOVIN Isoform 1 of Oocyte-secreted protein 1 OS=Bos taurus OX=9913 GN=OOSP1 PE=2 SV=1 CANONICAL=Q2Q0J1-1" }, "isoforms": [ { "isoform_ac": "Q2Q0J1-1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1/entry#Q2Q0J1-1", "sequence": { "sequence": "MKPSSGLRGLLVLFSLTWTCAGDWSAVKVRCSYFWFYAKIKPTLFHNLYMNPDEAFLGNDCPVTYVSPDAHYEFFYYSNKCGIITKTFQETLLLQTKIKYMSSNSGDTAEMPVSCVVTQQACMYHLSNETESGDDETSSEDMEVSYIMQSQNDLNTTFSLCAK", "length": 163, "header": "sp|Q2Q0J1-1|OOSP1_BOVIN Isoform 1 of Oocyte-secreted protein 1 OS=Bos taurus OX=9913 GN=OOSP1 PE=2 SV=1 CANONICAL=Q2Q0J1-1" }, "locus": { "chromosome": "15", "start_pos": 83102974, "end_pos": 83095401, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039223.3", "url": "https://www.ensembl.org/id/ENSBTAT00000039223.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039023.2", "url": "https://www.ensembl.org/id/ENSBTAP00000039023.2" } ] } }, { "isoform_ac": "Q2Q0J1-2", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1/entry#Q2Q0J1-2", "sequence": { "sequence": "MKPSSGLRGLLVLFSLTWTCAGDWSDFPGDSSASD", "length": 35, "header": "sp|Q2Q0J1-2|OOSP1_BOVIN Isoform 2 of Oocyte-secreted protein 1 OS=Bos taurus OX=9913 GN=OOSP1 PE=2 SV=1 CANONICAL=Q2Q0J1-1" }, "locus": { "chromosome": "15", "start_pos": 83100690, "end_pos": 83095401, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055939.2", "url": "https://www.ensembl.org/id/ENSBTAT00000055939.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000051497.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification and characterization of a novel bovine oocyte-specific secreted protein gene.", "journal": "Gene", "date": "2006", "authors": "Tremblay Karine, Vigneault Christian, McGraw Serge, Morin Guillaume, Sirard Marc-Andr\u00e9", "evidence": [ { "database": "UniProtKB", "id": "Q2Q0J1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1" } ], "reference": [ { "type": "PubMed", "id": "16580794", "url": "https://glygen.org/publication/PubMed/16580794" } ] } ], "pathway": [ { "id": "bta:616216", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616216", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A8MZH6-1", "protein_name": "Putative oocyte-secreted protein 1 homolog", "gene_name": "OOSP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTILGFKGLFYLHSLIWTCAGDWSAIQVHCTQFWFFARIKPTIFYNLYVNPDEVFLGDGCHVTHVLPNVYYEFFYHPHDCGIVTQPLQEVLLLKTKIRYISRDSTVRSEMPLSCVVHKQKCQ", "length": 123 }, "evidence": [ { "id": "Q2Q0J1", "url": "https://omabrowser.org/oma/group/Q2Q0J1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q08849-1", "protein_name": "Syntaxin-3", "gene_name": "Stx3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDRLEQLKAKQLTQDDDTDEVEIAIDNTAFMDEFFSEIEETRLNIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKTTDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDNIELNVMHTVDHVEKARDETKRAMKYQGQARKKLIIIIVIVVVLLGILALIIGLSVGLK", "length": 289 }, "evidence": [ { "id": "Q2Q0J1", "url": "https://omabrowser.org/oma/group/Q2Q0J1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2Q0J1", "url": "https://www.uniprot.org/uniprotkb/Q2Q0J1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2Q0J1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2Q0J1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2Q0J1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 155, "end_pos": 157 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2T9M0-1", "uniprot_ac": "Q2T9M0", "uniprot_id": "CFA96_BOVIN", "mass": { "chemical_mass": 34503.0, "monoisotopic_mass": 34503.0 }, "refseq": { "ac": "NP_001033225", "name": "cilia-and flagella-associated protein 96", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" }, "gene_names": [ { "name": "CFAP96", "type": "recommended", "evidence": [ { "id": "Q2T9M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0" } ] }, { "name": "C27H4orf47", "type": "synonym", "evidence": [ { "id": "NP_001033225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" } ] }, { "name": "CFAP96", "type": "synonym", "evidence": [ { "id": "NP_001033225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" } ] } ], "protein_names": [ { "name": "Cilia-and flagella-associated protein 96", "type": "recommended", "evidence": [ { "id": "Q2T9M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0/entry#names_and_taxonomy" } ] }, { "name": "UPF0602 protein C4orf47 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" } ] }, { "name": "chromosome 27 C4orf47 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" } ] }, { "name": "cilia-and flagella-associated protein 96", "type": "synonym", "evidence": [ { "id": "NP_001033225", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9M0", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP96", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0", "locus": { "chromosome": "27", "start_pos": 15689692, "end_pos": 15675423, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034430", "url": "https://www.ensembl.org/id/ENSBTAG00000034430" } ] } } ], "crossref": [ { "id": "Q2T9M0", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9M0", "database": "AlphaFoldDB", "categories": [] }, { "id": "523361", "url": "https://www.ncbi.nlm.nih.gov/gene/523361", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR029358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523361", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523361", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9M0", "url": "https://www.orthodb.org/?gene=Q2T9M0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31144", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31144", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31144:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31144:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF15239", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15239", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033225", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9M0", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9M0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAEGGKTDMERIGLFSEMEYITVGDKYVSQFNRPFNESASKNRQILPGGSKEMSNLQAGYFDPHFVRIFEGESYVNPNQVRRRYMMEEAKKNLSKAFLPSNGEKKPCGLGSYYGTIGGPVPFFSAQSKPKEKYEPPGKNLYTNPGKKGTGYGYANITIGKQFSHSSDLYDAAKLNNKKENEEHRRLLKGTAFKLNLYTREYFDTNPYMSEKPLPPIKKVEKKETVGNPFKPSSPGKKAGGMKAGTFDPYPSHSADPYVVKLKSPSSKSAKVFHPPGGPKSRPIESIMALNVKRALNMKNYKTASVQSY", "length": 309, "header": "sp|Q2T9M0-1|CFA96_BOVIN Isoform 1 of Cilia-and flagella-associated protein 96 OS=Bos taurus OX=9913 GN=CFAP96 PE=1 SV=1 CANONICAL=Q2T9M0-1" }, "isoforms": [ { "isoform_ac": "Q2T9M0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0/entry#Q2T9M0-1", "sequence": { "sequence": "MPAEGGKTDMERIGLFSEMEYITVGDKYVSQFNRPFNESASKNRQILPGGSKEMSNLQAGYFDPHFVRIFEGESYVNPNQVRRRYMMEEAKKNLSKAFLPSNGEKKPCGLGSYYGTIGGPVPFFSAQSKPKEKYEPPGKNLYTNPGKKGTGYGYANITIGKQFSHSSDLYDAAKLNNKKENEEHRRLLKGTAFKLNLYTREYFDTNPYMSEKPLPPIKKVEKKETVGNPFKPSSPGKKAGGMKAGTFDPYPSHSADPYVVKLKSPSSKSAKVFHPPGGPKSRPIESIMALNVKRALNMKNYKTASVQSY", "length": 309, "header": "sp|Q2T9M0-1|CFA96_BOVIN Isoform 1 of Cilia-and flagella-associated protein 96 OS=Bos taurus OX=9913 GN=CFAP96 PE=1 SV=1 CANONICAL=Q2T9M0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523361", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523361", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M0", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M0", "url": "https://www.uniprot.org/uniprotkb/Q2T9M0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9M0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9M0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9M0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9M9-1", "uniprot_ac": "Q2T9M9", "uniprot_id": "JHY_BOVIN", "mass": { "chemical_mass": 87993.0, "monoisotopic_mass": 87993.0 }, "refseq": { "ac": "NP_001033297", "name": "jhy protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" }, "gene_names": [ { "name": "JHY", "type": "recommended", "evidence": [ { "id": "Q2T9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9" } ] }, { "name": "C11orf63", "type": "synonym", "evidence": [ { "id": "NP_001033297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" } ] }, { "name": "C15H11orf63", "type": "synonym", "evidence": [ { "id": "NP_001033297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" } ] }, { "name": "JHY", "type": "synonym", "evidence": [ { "id": "NP_001033297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" } ] } ], "protein_names": [ { "name": "Jhy protein homolog", "type": "recommended", "evidence": [ { "id": "Q2T9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9/entry#names_and_taxonomy" } ] }, { "name": "jhy protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001033297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" } ] }, { "name": "uncharacterized protein C11orf63 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297" } ] } ], "function": [ { "annotation": "Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M9", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9#function" }, { "database": "UniProtKB", "id": "E9Q793", "url": "https://www.uniprot.org/uniprotkb/E9Q793#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9M9", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JHY", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9", "locus": { "chromosome": "15", "start_pos": 33584763, "end_pos": 33502740, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013989", "url": "https://www.ensembl.org/id/ENSBTAG00000013989" } ] } } ], "crossref": [ { "id": "Q2T9M9", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9M9", "database": "AlphaFoldDB", "categories": [] }, { "id": "615337", "url": "https://www.ncbi.nlm.nih.gov/gene/615337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9M9", "url": "https://www.orthodb.org/?gene=Q2T9M9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14726", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14726", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14726:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14726:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033297", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9M9", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9M9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHSKFIPTVSIQSPVHHTNIKVQSTEPSFKKEDLHLISKDSLESDSESPTQKIKSQSDLEDQIQDNDMEPDSLEEENLSETEEEASRKAAQRAKKENLHTQDAAAINSRQPTEDKYSHIRYDPNWKSKKEEGKLLPVEALPESVDSSTENLTLNPLYPSKEPSMDLSAGKGEQKSPRSTASLLGSEFVSPNYELSTHRTEPFSVLSDSDPEEKSSNLSRYLKSSSSRSEAFLPGSRGPRRRKSKQYFVEKNKLTLGLPTPRMDSYLQLHNKKRGEGHLEQISYPVRVTDKTSIQNARETGNVAIDPEDKWHQRAQQLKDYQEHWSQYEHEKSSSGPRGQSSETTNGQQPSRKPAKHKIRKQRRHRHGPKSLVTEELVVSQGNQNNTPRHQQNPNKPIDTEVTQETVVIMNATNDDLQYSSVLRSQDPTVTSNQYAPLHQISDKVLYKNPARYYPVTNANRERGHNDQEEKRFSYQQLHIDTLSDMHLNYLHELNKKHPSGSQKGSQSVSNINRQASTEKKKQPKLAYTETKYKNLEILWKFHSSSEEQPAKASPDSRLSQIMEQHQQALLQLTEVQPHEGASPGLTLPPILPRVESESQLSSERSQRNQVKISRSNSESYLFQLEKGKKHRKRSSIKSSKLKGYQNRDVKLGGLGPDLESIRDKMQKLIQQKEYAKQVKEYNMKALSIPSKPQTAITENKSAVPRQKALEYAKTIPKPKPSNLSDQASKEKKTPTHAGKEDTLPEISLLEVLQNRHEREKQAVAAFKVLHIV", "length": 773, "header": "sp|Q2T9M9-1|JHY_BOVIN Isoform 1 of Jhy protein homolog OS=Bos taurus OX=9913 GN=JHY PE=2 SV=1 CANONICAL=Q2T9M9-1" }, "isoforms": [ { "isoform_ac": "Q2T9M9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9/entry#Q2T9M9-1", "sequence": { "sequence": "MSHSKFIPTVSIQSPVHHTNIKVQSTEPSFKKEDLHLISKDSLESDSESPTQKIKSQSDLEDQIQDNDMEPDSLEEENLSETEEEASRKAAQRAKKENLHTQDAAAINSRQPTEDKYSHIRYDPNWKSKKEEGKLLPVEALPESVDSSTENLTLNPLYPSKEPSMDLSAGKGEQKSPRSTASLLGSEFVSPNYELSTHRTEPFSVLSDSDPEEKSSNLSRYLKSSSSRSEAFLPGSRGPRRRKSKQYFVEKNKLTLGLPTPRMDSYLQLHNKKRGEGHLEQISYPVRVTDKTSIQNARETGNVAIDPEDKWHQRAQQLKDYQEHWSQYEHEKSSSGPRGQSSETTNGQQPSRKPAKHKIRKQRRHRHGPKSLVTEELVVSQGNQNNTPRHQQNPNKPIDTEVTQETVVIMNATNDDLQYSSVLRSQDPTVTSNQYAPLHQISDKVLYKNPARYYPVTNANRERGHNDQEEKRFSYQQLHIDTLSDMHLNYLHELNKKHPSGSQKGSQSVSNINRQASTEKKKQPKLAYTETKYKNLEILWKFHSSSEEQPAKASPDSRLSQIMEQHQQALLQLTEVQPHEGASPGLTLPPILPRVESESQLSSERSQRNQVKISRSNSESYLFQLEKGKKHRKRSSIKSSKLKGYQNRDVKLGGLGPDLESIRDKMQKLIQQKEYAKQVKEYNMKALSIPSKPQTAITENKSAVPRQKALEYAKTIPKPKPSNLSDQASKEKKTPTHAGKEDTLPEISLLEVLQNRHEREKQAVAAFKVLHIV", "length": 773, "header": "sp|Q2T9M9-1|JHY_BOVIN Isoform 1 of Jhy protein homolog OS=Bos taurus OX=9913 GN=JHY PE=2 SV=1 CANONICAL=Q2T9M9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615337", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M9", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M9", "url": "https://www.uniprot.org/uniprotkb/Q2T9M9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 700, "end_pos": 702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9M9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 773, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9M9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9M9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 411, "end_pos": 413 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 723, "end_pos": 725 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9N0-1", "uniprot_ac": "Q2T9N0", "uniprot_id": "FSCB_BOVIN", "mass": { "chemical_mass": 87760.0, "monoisotopic_mass": 87760.0 }, "refseq": { "ac": "NP_001070014", "name": "fibrous sheath CABYR-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070014" }, "gene_names": [ { "name": "FSCB", "type": "recommended", "evidence": [ { "id": "Q2T9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ] }, { "name": "FSCB", "type": "synonym", "evidence": [ { "id": "NP_001070014", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070014" } ] } ], "protein_names": [ { "name": "Fibrous sheath CABYR-binding protein", "type": "recommended", "evidence": [ { "id": "Q2T9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0/entry#names_and_taxonomy" } ] }, { "name": "fibrous sheath CABYR-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001070014", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070014" } ] } ], "function": [ { "annotation": "May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0#function" }, { "database": "UniProtKB", "id": "A1EGX6", "url": "https://www.uniprot.org/uniprotkb/A1EGX6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSCB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0", "locus": { "chromosome": "21", "start_pos": 54269490, "end_pos": 54272713, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031934", "url": "https://www.ensembl.org/id/ENSBTAG00000031934" } ] } } ], "crossref": [ { "id": "Q2T9N0", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9N0", "database": "AlphaFoldDB", "categories": [] }, { "id": "767821", "url": "https://www.ncbi.nlm.nih.gov/gene/767821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q2T9N0", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q2T9N0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR043375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9N0", "url": "https://www.orthodb.org/?gene=Q2T9N0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36135", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36135", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36135:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36135:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001070014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070014", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9N0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEKDESEQSISAGRQEIRKRRRPSQPMVDKSQQTEVTEKKKQLSIPQSSGPKAALSIGNIPGSKLNYECHRVSSQLQQTWIKRKRVQDMADKSLQTETIAEEKKEEIKLVCEAVVPEEKPAAVEVGPEFPESVREVEVPPNRYSVQVKIDRSQQTTCTGDWTMMNFPQKEKLDKEQQTYFSESEIVVIGWPTNSFSKSKEGAQKRKSSGNIFLSEHPEFQPTTSSNEEIRRPSISRTVSISPTKKDSPVPLEDEKDVPVEVQPPAAEEISAEEQLPLAETTSEEVPVAVQPPPAEEPPLEAQPSPTEEAPGDEAPAKVEPTPAEEALSEKPPAEEALVEIQPSPVEEAAGDEAPAKVEATSSEETLLKEPLTEVQPPAAEEAPIQDTPELQLSPAVEAPAEEAPAEAEPPPAEEAPAEEAPEVQSPPAEEAPAEEPPEIQSPPAEEAPAEEPPEVQSPPAEEAPAEEAPEVQSPPAEEAPAEEPPEVQSPPAEEVPAGEPPEVQSPPAEEAPAEEAPEVQSPPAEEVPAEEALAEVEPPPAEEAPAGEPSEVQSPPAEEAPAEEAPEVQSPPSEEAPAEEAPEVQSVPAGQAPAEEPLEVQPPPAEDATEEEASEVQSLPTDEAPAEEGLGFQSPPADKAPEEEAPEVQSPPAEEAPAEEPPEVQSLPADEAPAEEATEEVQSPPTEESPAEEAPAELQPPSTEETTSEMVSVEKQPSLTEEPFITPISLEETSAEVLLPPFEQTPADEALVENVSPVDQAPKEADVLVEKLESGNLDDKPKSEEPLERDTIPKDSSGTKNEGVSFEIKGVIHIELE", "length": 818, "header": "sp|Q2T9N0-1|FSCB_BOVIN Isoform 1 of Fibrous sheath CABYR-binding protein OS=Bos taurus OX=9913 GN=FSCB PE=2 SV=1 CANONICAL=Q2T9N0-1" }, "isoforms": [ { "isoform_ac": "Q2T9N0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0/entry#Q2T9N0-1", "sequence": { "sequence": "MEEKDESEQSISAGRQEIRKRRRPSQPMVDKSQQTEVTEKKKQLSIPQSSGPKAALSIGNIPGSKLNYECHRVSSQLQQTWIKRKRVQDMADKSLQTETIAEEKKEEIKLVCEAVVPEEKPAAVEVGPEFPESVREVEVPPNRYSVQVKIDRSQQTTCTGDWTMMNFPQKEKLDKEQQTYFSESEIVVIGWPTNSFSKSKEGAQKRKSSGNIFLSEHPEFQPTTSSNEEIRRPSISRTVSISPTKKDSPVPLEDEKDVPVEVQPPAAEEISAEEQLPLAETTSEEVPVAVQPPPAEEPPLEAQPSPTEEAPGDEAPAKVEPTPAEEALSEKPPAEEALVEIQPSPVEEAAGDEAPAKVEATSSEETLLKEPLTEVQPPAAEEAPIQDTPELQLSPAVEAPAEEAPAEAEPPPAEEAPAEEAPEVQSPPAEEAPAEEPPEIQSPPAEEAPAEEPPEVQSPPAEEAPAEEAPEVQSPPAEEAPAEEPPEVQSPPAEEVPAGEPPEVQSPPAEEAPAEEAPEVQSPPAEEVPAEEALAEVEPPPAEEAPAGEPSEVQSPPAEEAPAEEAPEVQSPPSEEAPAEEAPEVQSVPAGQAPAEEPLEVQPPPAEDATEEEASEVQSLPTDEAPAEEGLGFQSPPADKAPEEEAPEVQSPPAEEAPAEEPPEVQSLPADEAPAEEATEEVQSPPTEESPAEEAPAELQPPSTEETTSEMVSVEKQPSLTEEPFITPISLEETSAEVLLPPFEQTPADEALVENVSPVDQAPKEADVLVEKLESGNLDDKPKSEEPLERDTIPKDSSGTKNEGVSFEIKGVIHIELE", "length": 818, "header": "sp|Q2T9N0-1|FSCB_BOVIN Isoform 1 of Fibrous sheath CABYR-binding protein OS=Bos taurus OX=9913 GN=FSCB PE=2 SV=1 CANONICAL=Q2T9N0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 322, "start_aa": "Thr", "end_pos": 322, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr322", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 182, "end_pos": 182, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "site_lbl": "Ser182" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "site_lbl": "Ser25" }, { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "site_lbl": "Ser57" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767821", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sperm fibrous sheath", "id": "GO:0035686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035686", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of protein sumoylation", "id": "GO:0033234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033234", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N0", "url": "https://www.uniprot.org/uniprotkb/Q2T9N0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 755, "end_pos": 757, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9N0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 818, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9N0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9N0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 322 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 25, 57, 182 ], "sequon_annotation_sites": [ { "start_pos": 755, "end_pos": 757 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9N1-1", "uniprot_ac": "Q2T9N1", "uniprot_id": "F1142_BOVIN", "mass": { "chemical_mass": 54825.0, "monoisotopic_mass": 54825.0 }, "refseq": { "ac": "NP_001033166", "name": "protein FAM114A2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033166" }, "gene_names": [ { "name": "FAM114A1", "type": "recommended", "evidence": [ { "id": "Q2T9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1" } ] }, { "name": "FAM114A1", "type": "synonym", "evidence": [ { "id": "NP_001033166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033166" } ] }, { "name": "FAM114A2", "type": "synonym", "evidence": [ { "id": "NP_001033166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033166" } ] } ], "protein_names": [ { "name": "Protein FAM114A2", "type": "recommended", "evidence": [ { "id": "Q2T9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1/entry#names_and_taxonomy" } ] }, { "name": "protein FAM114A2", "type": "synonym", "evidence": [ { "id": "NP_001033166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033166" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9N1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM114A1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1", "locus": { "chromosome": "6", "start_pos": 58156095, "end_pos": 58091445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033160", "url": "https://www.ensembl.org/id/ENSBTAG00000033160" } ] } } ], "crossref": [ { "id": "Q2T9N1", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9N1", "database": "AlphaFoldDB", "categories": [] }, { "id": "511198", "url": "https://www.ncbi.nlm.nih.gov/gene/511198", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511198", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511198", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9N1", "url": "https://www.orthodb.org/?gene=Q2T9N1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12842:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12842:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05334", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05334", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033166", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9N1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9N1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNKDDLETAVITEATPIREDENCEPVKNFESVDQSAKSESKSEPVASTRKRPESKPSSDLETEVLPVQASQAAGKETVSKDVPQSGWGYWGSWGKSLLSSASATVATVGQGISNVIEKAETSLGIPSPSEISTEVQYATGETSAKENGNSSPMSGPFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRTSTLSQVLREAKEKEELWTSNEVTMETDKKTHYGLLFDEFQGLSHLEALEMLSRESEIKVKSILNSLSGEELETLKLELEQLKEAFSLAELCEEEEEEKKGGEDFTKEITELFSQLHVSSKPEKLARARNTAYEWIRTSLAKPLKEKEEGEKQLEAENTEQINNKSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTTIERSRALCQMTVLLCKELSCLSKEFTTCLTTAGVKEKADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISFIENKTELPEA", "length": 500, "header": "sp|Q2T9N1-1|F1142_BOVIN Isoform 1 of Protein FAM114A2 OS=Bos taurus OX=9913 GN=FAM114A1 PE=2 SV=1 CANONICAL=Q2T9N1-1" }, "isoforms": [ { "isoform_ac": "Q2T9N1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1/entry#Q2T9N1-1", "sequence": { "sequence": "MSNKDDLETAVITEATPIREDENCEPVKNFESVDQSAKSESKSEPVASTRKRPESKPSSDLETEVLPVQASQAAGKETVSKDVPQSGWGYWGSWGKSLLSSASATVATVGQGISNVIEKAETSLGIPSPSEISTEVQYATGETSAKENGNSSPMSGPFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRTSTLSQVLREAKEKEELWTSNEVTMETDKKTHYGLLFDEFQGLSHLEALEMLSRESEIKVKSILNSLSGEELETLKLELEQLKEAFSLAELCEEEEEEKKGGEDFTKEITELFSQLHVSSKPEKLARARNTAYEWIRTSLAKPLKEKEEGEKQLEAENTEQINNKSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTTIERSRALCQMTVLLCKELSCLSKEFTTCLTTAGVKEKADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISFIENKTELPEA", "length": 500, "header": "sp|Q2T9N1-1|F1142_BOVIN Isoform 1 of Protein FAM114A2 OS=Bos taurus OX=9913 GN=FAM114A1 PE=2 SV=1 CANONICAL=Q2T9N1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1" } ], "site_lbl": "Ser152" }, { "start_pos": 215, "end_pos": 215, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1" } ], "site_lbl": "Ser215" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9N1", "url": "https://www.uniprot.org/uniprotkb/Q2T9N1" } ], "site_lbl": "Ser93" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511198", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511198", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9N1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 500, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9N1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9N1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 93, 152, 215 ], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 493, "end_pos": 495 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9P0-1", "uniprot_ac": "Q2T9P0", "uniprot_id": "EFCB3_BOVIN", "mass": { "chemical_mass": 50198.0, "monoisotopic_mass": 50198.0 }, "refseq": { "ac": "NP_001033230", "name": "EF-hand calcium-binding domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033230" }, "gene_names": [ { "name": "EFCAB3", "type": "recommended", "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" } ] }, { "name": "EFCAB3", "type": "synonym", "evidence": [ { "id": "NP_001033230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033230" } ] } ], "protein_names": [ { "name": "EF-hand calcium-binding domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0/entry#names_and_taxonomy" } ] }, { "name": "EF-hand calcium-binding domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001033230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033230" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9P0", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0", "locus": { "chromosome": "19", "start_pos": 46862871, "end_pos": 46771087, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006943", "url": "https://www.ensembl.org/id/ENSBTAG00000006943" } ] } } ], "crossref": [ { "id": "Q2T9P0", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9P0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524320", "url": "https://www.ncbi.nlm.nih.gov/gene/524320", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524320", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524320", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9P0", "url": "https://www.orthodb.org/?gene=Q2T9P0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22656:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22656:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF13833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033230", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9P0", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9P0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVSEIKAKFKLNPLTKVPNFHSRRDKDLPGLLPCQLQHKERKLSPSQMRAFQDAYNFFNKDKTGCIDLHGMMCTLAKLGMNLTKHDVHNELRCADIDQDGKVNFSDFLKVLTDKNRFLKAVVPEKGTCLDLAGNPGILLFEILSKLIETSALPKKAISEIVSYFRRKFQETTSGMVWSPDTTGYGKRRFKPDICTPPSSSTAAFANAARIAIMKEKDLFKFLDELKKCNPPSDSPYSKIPIFPLFPNVDGVVMGKPFKDIQKLEMLKRKEPLNFFENYFFHKKDWKTQEANIKPVDPTSGYTTDILTIDQMLKRKQNWTVADAAAIKPHVKRATETYNLGIALEHRKQMLNLWRKIRGDLIGIESKNESFYDTFSTYTWSWNVCQELLSPKDLKLYDAHVNRNALHNSVFSSSSDISECDTDTGRKRKRKGFKGFRQ", "length": 438, "header": "sp|Q2T9P0-1|EFCB3_BOVIN Isoform 1 of EF-hand calcium-binding domain-containing protein 3 OS=Bos taurus OX=9913 GN=EFCAB3 PE=1 SV=1 CANONICAL=Q2T9P0-1" }, "isoforms": [ { "isoform_ac": "Q2T9P0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0/entry#Q2T9P0-1", "sequence": { "sequence": "MAVSEIKAKFKLNPLTKVPNFHSRRDKDLPGLLPCQLQHKERKLSPSQMRAFQDAYNFFNKDKTGCIDLHGMMCTLAKLGMNLTKHDVHNELRCADIDQDGKVNFSDFLKVLTDKNRFLKAVVPEKGTCLDLAGNPGILLFEILSKLIETSALPKKAISEIVSYFRRKFQETTSGMVWSPDTTGYGKRRFKPDICTPPSSSTAAFANAARIAIMKEKDLFKFLDELKKCNPPSDSPYSKIPIFPLFPNVDGVVMGKPFKDIQKLEMLKRKEPLNFFENYFFHKKDWKTQEANIKPVDPTSGYTTDILTIDQMLKRKQNWTVADAAAIKPHVKRATETYNLGIALEHRKQMLNLWRKIRGDLIGIESKNESFYDTFSTYTWSWNVCQELLSPKDLKLYDAHVNRNALHNSVFSSSSDISECDTDTGRKRKRKGFKGFRQ", "length": 438, "header": "sp|Q2T9P0-1|EFCB3_BOVIN Isoform 1 of EF-hand calcium-binding domain-containing protein 3 OS=Bos taurus OX=9913 GN=EFCAB3 PE=1 SV=1 CANONICAL=Q2T9P0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 299, "start_aa": "Thr", "end_pos": 299, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr299", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P0", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" } ], "site_lbl": "Tyr279" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524320", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524320", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P0", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9P0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 438, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9P0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9P0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 1", "eco_id": "ECO_0000255", "start_pos": 47, "end_pos": 82, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 2", "eco_id": "ECO_0000255", "start_pos": 83, "end_pos": 118, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0#function" }, { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "binding_site_uniprot": 100, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 100, "end_pos": 100, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0#function" }, { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "binding_site_uniprot": 102, "amino_acid": "Lys", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 102, "end_pos": 102, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0#function" }, { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "binding_site_uniprot": 107, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 107, "end_pos": 107, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0#function" }, { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "binding_site_uniprot": 96, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 96, "end_pos": 96, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0#function" }, { "id": "Q2T9P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P0" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "binding_site_uniprot": 98, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 98, "end_pos": 98, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 299 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 279 ], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9P5-1", "uniprot_ac": "Q2T9P5", "uniprot_id": "CC50C_BOVIN", "mass": { "chemical_mass": 39022.0, "monoisotopic_mass": 39022.0 }, "refseq": { "ac": "NP_001033239", "name": "cell cycle control protein 50C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033239" }, "gene_names": [ { "name": "TMEM30C", "type": "recommended", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ] }, { "name": "CDC50C", "type": "synonym", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ] }, { "name": "TMEM30C", "type": "synonym", "evidence": [ { "id": "NP_001033239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033239" } ] } ], "protein_names": [ { "name": "Cell cycle control protein 50C", "type": "recommended", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 30C", "type": "synonym", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5/entry#names_and_taxonomy" } ] }, { "name": "cell cycle control protein 50C", "type": "synonym", "evidence": [ { "id": "NP_001033239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033239" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM30C", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5", "locus": { "chromosome": "1", "start_pos": 44508871, "end_pos": 44483988, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013667", "url": "https://www.ensembl.org/id/ENSBTAG00000013667" } ] } } ], "crossref": [ { "id": "Q2T9P5", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9P5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013667", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013667", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531379", "url": "https://www.ncbi.nlm.nih.gov/gene/531379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531379", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531379", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDIFWLH", "url": "https://omabrowser.org/oma/group/NDIFWLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9P5", "url": "https://www.orthodb.org/?gene=Q2T9P5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10926", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10926", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10926:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10926:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033239", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9P5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRKCQDYESRLPDNTAVKQQQLPAFRLQLTASEILSGFFAIGLFCLGMGIILLLSAKSIKEVEINYTEKCATCAKLREEATNFDKECNCSISFYLPQKMEGNVYLYYKLYGFYQNLYRYILSRSNIQLVGADVKDVRNCAPFRTSDNGLPIAPCGAIANSMFNDTIVLWYNFNSSTHIRVPMVRTETAWWTDKYVKFQNPAFQNLSSAFAGTAKPPNWPKPVYELDENDPGNNGFINDDFIVWMRTAAFPNFKKLYRRLHRIGNFTEGLPAGSYSFIINYNFPVSRFQGQKAVVLSTLTWSGGSSLFLALAYLVTGAVTLLASFSMMALHLKLKERKTFFLQ", "length": 343, "header": "sp|Q2T9P5-1|CC50C_BOVIN Isoform 1 of Cell cycle control protein 50C OS=Bos taurus OX=9913 GN=TMEM30C PE=2 SV=1 CANONICAL=Q2T9P5-1" }, "isoforms": [ { "isoform_ac": "Q2T9P5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5/entry#Q2T9P5-1", "sequence": { "sequence": "MKRKCQDYESRLPDNTAVKQQQLPAFRLQLTASEILSGFFAIGLFCLGMGIILLLSAKSIKEVEINYTEKCATCAKLREEATNFDKECNCSISFYLPQKMEGNVYLYYKLYGFYQNLYRYILSRSNIQLVGADVKDVRNCAPFRTSDNGLPIAPCGAIANSMFNDTIVLWYNFNSSTHIRVPMVRTETAWWTDKYVKFQNPAFQNLSSAFAGTAKPPNWPKPVYELDENDPGNNGFINDDFIVWMRTAAFPNFKKLYRRLHRIGNFTEGLPAGSYSFIINYNFPVSRFQGQKAVVLSTLTWSGGSSLFLALAYLVTGAVTLLASFSMMALHLKLKERKTFFLQ", "length": 343, "header": "sp|Q2T9P5-1|CC50C_BOVIN Isoform 1 of Cell cycle control protein 50C OS=Bos taurus OX=9913 GN=TMEM30C PE=2 SV=1 CANONICAL=Q2T9P5-1" }, "locus": { "chromosome": "1", "start_pos": 44508634, "end_pos": 44485049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018165.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018165.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018165.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018165.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 164, "start_aa": "Asn", "end_pos": 164, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn164", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 205, "start_aa": "Asn", "end_pos": 205, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn205", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 265, "start_aa": "Asn", "end_pos": 265, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn265", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 66, "start_aa": "Asn", "end_pos": 66, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn66", "evidence": [ { "id": "Q2T9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531379", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531379", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R6H6-1", "protein_name": "Cell cycle control protein 50C", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKRKSQDSQSRLPDNTAVKQQQLPAYRLQLSAKEILSGFFATGVFCLGIGIILLLSAKSIKEIEINYTEKCANCAKLRENAANFAKECACSIPFYLSEAMRGNVYMYYKLYGFYQNLYRYILSRSNSQLVGTDIKDVTNCSPFKNSPNGTPIAPCGAIANSIFNDTIILSYNLNSSIHIKVPMLRSGITWWTDKYVKFQNPSSHNLSSAFAGTTKPPYWPKPAYELDEEDPGNNGFINDDFIVWMRTAAFPTFKKLYRRLHRVQHFTEGLPAGDQVYLHHDNPKVSEKRRLWGDSTGNQSDKHRRQEEQEKAILKCQTLESKLVNLAREARKSEGGDCQDREE", "length": 343 }, "evidence": [ { "id": "Q2T9P5", "url": "https://omabrowser.org/oma/group/Q2T9P5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M9X1-1", "protein_name": "Cell cycle control protein", "gene_name": "LOC100755866", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEVMPQYDLSRLPENTALKQQKLPAHRLDLSASVVLSIFFATGGFCLCMGVILILSAKSTKELEINYTNICANCAQLREDSSNFDKECTCSVPFYLPENMEGNVYMYYKLYGFHQNLYRYILSRSNRQLLGKDIWDVKDCSPFQVSRNSTPIIPCGAIANSIFNDTITLSYNLNSSIHIEVPMLKSGLAWWTDKYVKFQNPRASDLASAFAGSAKPLHWTKPVYELDTDDPGNNGFVNEDLIVWMRTAAFPTFKKLYRRLKRVDYFAVGLPAGNYSFNISYNFPVTVFRGEKSVVLSTLTWIGGGGLFLGLTYTVTGALTLLASFAILAIHLMLKRTKKNFL", "length": 342 }, "evidence": [ { "id": "Q2T9P5", "url": "https://omabrowser.org/oma/group/Q2T9P5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XS32-1", "protein_name": "Cell cycle control protein", "gene_name": "TMEM30CP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKNKKSSAPQEAETRPSRCPDNSAFKQQKLPAWKPQLTAASVLSTFFLTGAFCLSVGVSLIVAAKSVREIQVDYSDKCSHCSKLRENSSNWNSECLCSINITLAEDMLGDVFMYYGLQNFYQNHRRYALSRSDEQLLGRNVDVQNSYCAPFATYQNGTPMAPCGAIANSMFNDTIDLFYNFNSSVIQVPLLKTGNSWWTDKNVKFRNPESHNLSAAFAGTARPPYWHKAVYLLDEEDEKNNGYINDDFIIWMRVSAFATFRNLYRRISRKGQFTDGLPAGNYTFHISYNFPVSKFKGKKYVILSTMVWSGGSNPFLGIAYLVCGAAATLTDALKLFPECRNNAEELRSRIA", "length": 351 }, "evidence": [ { "id": "Q2T9P5", "url": "https://omabrowser.org/oma/group/Q2T9P5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4AAH8-1", "protein_name": "Cell cycle control protein", "gene_name": "Tmem30c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEMVPQYDLSRLPENTALKQQTLPAQQLNLSASIVLSIFFATGGFCLSVGVILLLFAKSTKEIEINYTNMCANCAQLREDSSNFDKECNCSLPLYLPEKMEGDVYMYYKLYGFYQNLYRYILSRSNSQLVGKDIWDTTNCSPFQVSKNDTPIIPCGAIANSIFNDTITLSYNLNSSTQIEVPMLRSGLTWWTDKYVKFRNPRTSNFTSTFAGSSKPLHWAKPVYELDLEDPGNNGFVNEDFIVWMRTAAFPTFRKLYRRLRREDSFADGLPAGNYSLSISYNFPVTMFQGEKSVILSTLTWFGGGGLFLGLTYTVTGALTLLASFAILAVHLKLKRNKLSFL", "length": 342 }, "evidence": [ { "id": "Q2T9P5", "url": "https://omabrowser.org/oma/group/Q2T9P5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D4D7-1", "protein_name": "Cell cycle control protein 50C", "gene_name": "Tmem30c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMMPQYDLSRLPENTALKQQTLPTQQLNLSASVVLSIFFITGGFCLSIGIILLLSAKSTKKIEINYTKTCANCAQLRENSSNFDKACNCSLPFYLPEKMEGDVYMYYKLYGFYQNLYQYILSRSNSQLVGKDIWDTTNCDPFQVSHNDTPIIPCGAIANSIFNDTITLSYNLNSSTQIEVPMLKSGLTWWTDKYVKFRNPRSSNFTSTFAGSSKPLHWAKPIYELDLDDPGNNGFLNEDFIVWMRTAAFPTFKKLYRRLKRVHAFAEGLPAGNYSLSISYNFPVTMFQGEKSIVLSTLTWIGGGGLFLGLTYTVTGALTLLASFAILTIHLMLKRSKLNFL", "length": 342 }, "evidence": [ { "id": "Q2T9P5", "url": "https://omabrowser.org/oma/group/Q2T9P5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aminophospholipid flippase activity", "id": "GO:0015247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015247", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P5", "url": "https://www.uniprot.org/uniprotkb/Q2T9P5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9P5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 343, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9P5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9P5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 66, 164, 205, 265 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Q2-1", "uniprot_ac": "Q2T9Q2", "uniprot_id": "UBL4B_BOVIN", "mass": { "chemical_mass": 18879.0, "monoisotopic_mass": 18879.0 }, "refseq": { "ac": "NP_001074203", "name": "ubiquitin-like protein 4B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074203" }, "gene_names": [ { "name": "UBL4B", "type": "recommended", "evidence": [ { "id": "Q2T9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2" } ] }, { "name": "UBL4B", "type": "synonym", "evidence": [ { "id": "NP_001074203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074203" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein 4B", "type": "recommended", "evidence": [ { "id": "Q2T9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-like protein 4B", "type": "synonym", "evidence": [ { "id": "NP_001074203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074203" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q2", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBL4B", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2", "locus": { "chromosome": "3", "start_pos": 33316136, "end_pos": 33317748, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016389", "url": "https://www.ensembl.org/id/ENSBTAG00000016389" } ] } } ], "crossref": [ { "id": "Q2T9Q2", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Q2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016389", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016389", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529388", "url": "https://www.ncbi.nlm.nih.gov/gene/529388", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529388", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529388", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ASINVIM", "url": "https://omabrowser.org/oma/group/ASINVIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9Q2", "url": "https://www.orthodb.org/?gene=Q2T9Q2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47905:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47905:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001074203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074203", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9Q2", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Q2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLTVKLLLGRRCSLKVSGQESVAMLKKLVSERLHVPEEQQHLLFRGQLLADDKRLSDYRIGPNASISVVVRPLEKPAPEDTRLPQPLWHHLGQVLAKHFGPQDTEAMLQLLRREHEECLQRISLGDLEQLARYLLTKEPLAQPTGEREPEVLSPNKEEEKEAVQ", "length": 165, "header": "sp|Q2T9Q2-1|UBL4B_BOVIN Isoform 1 of Ubiquitin-like protein 4B OS=Bos taurus OX=9913 GN=UBL4B PE=2 SV=1 CANONICAL=Q2T9Q2-1" }, "isoforms": [ { "isoform_ac": "Q2T9Q2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2/entry#Q2T9Q2-1", "sequence": { "sequence": "MFLTVKLLLGRRCSLKVSGQESVAMLKKLVSERLHVPEEQQHLLFRGQLLADDKRLSDYRIGPNASISVVVRPLEKPAPEDTRLPQPLWHHLGQVLAKHFGPQDTEAMLQLLRREHEECLQRISLGDLEQLARYLLTKEPLAQPTGEREPEVLSPNKEEEKEAVQ", "length": 165, "header": "sp|Q2T9Q2-1|UBL4B_BOVIN Isoform 1 of Ubiquitin-like protein 4B OS=Bos taurus OX=9913 GN=UBL4B PE=2 SV=1 CANONICAL=Q2T9Q2-1" }, "locus": { "chromosome": "3", "start_pos": 33317557, "end_pos": 33317063, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021793.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021793.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021793.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021793.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529388", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529388", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6B3P4-1", "protein_name": "Ubiquitin-like 4B", "gene_name": "Ubl4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFLTVKLLLGRRCSLKVSGKESVATLKKLVSQHLQVPEEQQHLLFRGQLLADDKYLSDYSIGPNASINVIMRPQEDVALDKTHQTQPLWLQLGQVLDKHFGSKDAKTVLGFLRQEHEERLQRLSLEGLEQLVGQLLAQQQLDELAEEKEAPAVASELQQNDEGEGGGTGGGGKEEEEKEEAEKGADQ", "length": 187 }, "evidence": [ { "id": "Q2T9Q2", "url": "https://omabrowser.org/oma/group/Q2T9Q2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N7F7-1", "protein_name": "Ubiquitin-like protein 4B", "gene_name": "UBL4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLTVKLLLGQRCSLKVSGQESVATLKRLVSRRLKVPEEQQHLLFRGQLLEDDKHLSDYCIGPNASINVIMQPLEKMALKEAHQPQTQPLWHQLGLVLAKHFEPQDAKAVLQLLRQEHEERLQKISLEHLEQLAQYLLAEEPHVEPAGERELEAKARPQSSCDMEEKEEAAADQ", "length": 174 }, "evidence": [ { "id": "Q2T9Q2", "url": "https://omabrowser.org/oma/group/Q2T9Q2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQ84-1", "protein_name": "Ubiquitin-like protein 4B", "gene_name": "Ubl4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLTVKLLLGRRCSLKVSGKESVATLKKLVSQHLQVPEEQQHLLFRGQLLADDKYLSDYSIGPNASINVIMRPPEDAALDKTHQTQPLWLQLGQVLDKHFGAKDAKTVLGFLRQEHEERLQRLSLEALEQLVGQLLAQQQLDELAEEKEAPAVASELEQNNGGGGGGGGTGGEGGGKKEEEEGEEADQ", "length": 188 }, "evidence": [ { "id": "Q2T9Q2", "url": "https://omabrowser.org/oma/group/Q2T9Q2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q2", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Q2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Q2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Q2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q2" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 76, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Q3-1", "uniprot_ac": "Q2T9Q3", "uniprot_id": "CFA68_BOVIN", "mass": { "chemical_mass": 20139.0, "monoisotopic_mass": 20139.0 }, "refseq": { "ac": "NP_001033266", "name": "cilia- and flagella-associated protein 68", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" }, "gene_names": [ { "name": "CFAP68", "type": "recommended", "evidence": [ { "id": "Q2T9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ] }, { "name": "C15H11orf1", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] }, { "name": "CFAP68", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein 68", "type": "recommended", "evidence": [ { "id": "Q2T9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3/entry#names_and_taxonomy" } ] }, { "name": "UPF0686 protein C11orf1 homolog-like", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] }, { "name": "UPF0686 protein C11orf1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] }, { "name": "chromosome 15 C11orf1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] }, { "name": "cilia- and flagella-associated protein 68", "type": "synonym", "evidence": [ { "id": "NP_001033266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE6#function" }, { "database": "UniProtKB", "id": "ARBA00035003", "url": "https://www.uniprot.org/uniprotkb/ARBA00035003#function" }, { "database": "UniProtKB", "id": "G3N358", "url": "https://www.uniprot.org/uniprotkb/G3N358#function" }, { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3#function" }, { "database": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" }, { "database": "UniProtKB", "id": "A0AAF6YN86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN86#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP68", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3", "locus": { "chromosome": "15", "start_pos": 22232756, "end_pos": 22228117, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004951", "url": "https://www.ensembl.org/id/ENSBTAG00000004951" } ] } } ], "crossref": [ { "id": "Q2T9Q3", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Q3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004951", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004951", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538766", "url": "https://www.ncbi.nlm.nih.gov/gene/538766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR009524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538766", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538766", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9Q3", "url": "https://www.orthodb.org/?gene=Q2T9Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31180:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31180:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF06608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033266", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N358", "url": "https://www.uniprot.org/uniprotkb/G3N358", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N358-1", "url": "https://www.uniprot.org/uniprotkb/G3N358-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Q3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTATDYHCYSEFFQRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQFGHYFETTYDTSYNNRRPLSTHRFKREPHWFPGHQPELVPPPYKCTEKSTYMTSYSKPQTDHHSVCVWNPSNCQFQSP", "length": 169, "header": "sp|Q2T9Q3-1|CFA68_BOVIN Isoform 1 of Cilia- and flagella-associated protein 68 OS=Bos taurus OX=9913 GN=CFAP68 PE=1 SV=1 CANONICAL=Q2T9Q3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAE6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3/entry#A0AAA9SAE6-1", "sequence": { "sequence": "VIWVIILSLPGELGRPGLVSSLVLKNMERQSKVCCYSAIKSSDTSSSTSKYSSSEKRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQFGHYFETTYDTSYNNRRPLSTHRFKREPHWFPGHQPELVPPPYKCTEKSTYMTSYSKPQTDHHSVCVWNPSNCQFQSP", "length": 211, "header": "tr|A0AAA9SAE6-1|A0AAA9SAE6_BOVIN Computationally mapped isoform of Cilia and flagella associated protein 68 OS=Bos taurus OX=9913 GN=CFAP68 PE=4 SV=1 CANONICAL=Q2T9Q3-1" }, "locus": { "chromosome": "15", "start_pos": 22232634, "end_pos": 22230007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109063.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109063.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082308.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082308.1" } ] } }, { "isoform_ac": "A0AAF6YN86-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3/entry#A0AAF6YN86-1", "sequence": { "sequence": "MTATDYHCYSEFFQRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQGLSENLTGSQDINLSWFLLHTNAQKSQLT", "length": 120, "header": "tr|A0AAF6YN86-1|A0AAF6YN86_BOVIN Computationally mapped isoform of Cilia and flagella associated protein 68 OS=Bos taurus OX=9913 GN=CFAP68 PE=4 SV=1 CANONICAL=Q2T9Q3-1" }, "locus": { "chromosome": "15", "start_pos": 22232554, "end_pos": 22228480, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006511.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006511.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006511.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006511.5" } ] } }, { "isoform_ac": "G3N358-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3/entry#G3N358-1", "sequence": { "sequence": "IHLRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQFGHYFETTYDTSYNNRRPLSTHSRFHCIFREPHWFPGHQPELVPPPYKCTEKSTYMTSYSKPQTDHHSVCVWNPSNCQFQSP", "length": 162, "header": "tr|G3N358-1|G3N358_BOVIN Computationally mapped isoform of Cilia and flagella associated protein 68 OS=Bos taurus OX=9913 GN=CFAP68 PE=4 SV=3 CANONICAL=Q2T9Q3-1" }, "locus": { "chromosome": "15", "start_pos": 22232634, "end_pos": 22231053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064006.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064006.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056332.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056332.3" } ] } }, { "isoform_ac": "Q2T9Q3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3/entry#Q2T9Q3-1", "sequence": { "sequence": "MTATDYHCYSEFFQRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQFGHYFETTYDTSYNNRRPLSTHRFKREPHWFPGHQPELVPPPYKCTEKSTYMTSYSKPQTDHHSVCVWNPSNCQFQSP", "length": 169, "header": "sp|Q2T9Q3-1|CFA68_BOVIN Isoform 1 of Cilia- and flagella-associated protein 68 OS=Bos taurus OX=9913 GN=CFAP68 PE=1 SV=1 CANONICAL=Q2T9Q3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023-06-22", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:538766", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538766", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q3", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Q3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 169, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Q3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Q3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2T9T0-1", "uniprot_ac": "Q2T9T0", "uniprot_id": "SAXO4_BOVIN", "mass": { "chemical_mass": 47759.0, "monoisotopic_mass": 47759.0 }, "refseq": { "ac": "NP_001033133", "name": "stabilizer of axonemal microtubules 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" }, "gene_names": [ { "name": "SAXO4", "type": "recommended", "evidence": [ { "id": "Q2T9T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ] }, { "name": "C11orf66", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" } ] }, { "name": "C29H11orf66", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" } ] }, { "name": "PPP1R32", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" }, { "id": "Q2T9T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ] }, { "name": "SAXO4", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" } ] } ], "protein_names": [ { "name": "Stabilizer of axonemal microtubules 4", "type": "recommended", "evidence": [ { "id": "Q2T9T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0/entry#names_and_taxonomy" } ] }, { "name": "IIIG9 protein", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" } ] }, { "name": "Protein phosphatase 1 regulatory subunit 32", "type": "synonym", "evidence": [ { "id": "Q2T9T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0/entry#names_and_taxonomy" } ] }, { "name": "stabilizer of axonemal microtubules 4", "type": "synonym", "evidence": [ { "id": "NP_001033133", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAXO4", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0", "locus": { "chromosome": "29", "start_pos": 39962267, "end_pos": 39953733, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014830", "url": "https://www.ensembl.org/id/ENSBTAG00000014830" } ] } } ], "crossref": [ { "id": "Q2T9T0", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9T0", "database": "AlphaFoldDB", "categories": [] }, { "id": "506337", "url": "https://www.ncbi.nlm.nih.gov/gene/506337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR031410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9T0", "url": "https://www.orthodb.org/?gene=Q2T9T0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34349", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34349", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34349:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34349:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF15691", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15691", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033133", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9T0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGKLPLGVVSPYVKMSSGGCTDPLKFYATSYCTAYGREDFKPRVGSHRGTGYKSNYRPVVFYQPHLDALDNTATGEQGCNNFQTVTSQSYRPLEVPDGTHPLPWNLHQTNSGYSREKASAVTPIKEVRKVHFDTQDYGPQAITGLEPKDAPLLHQQQNKGSLEWENAGHGPRFMTSEYNSKYLKEPSHQPDLLQKNSVGAKEETGFTEESNKNPIVFQPPSQALPGDPVLLPGRSVTKSDFLPISHPHGDEFLPVLARGSERETGFSRVNERTLNPRVPPPCPEPSSMNHWQFQSPQRMQQTNVALLGRETVGNKEPSGFSLNNPSYVRSPYDPDMDNRYLTTYNQGYFENIPKGLDREGWTRGGLQPQKPGGYALNQPVTRLEATPTPTESLRRLHPHLGRTLISVDPFYRTAPPSGHVSRFTAPN", "length": 428, "header": "sp|Q2T9T0-1|SAXO4_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 4 OS=Bos taurus OX=9913 GN=SAXO4 PE=1 SV=1 CANONICAL=Q2T9T0-1" }, "isoforms": [ { "isoform_ac": "Q2T9T0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0/entry#Q2T9T0-1", "sequence": { "sequence": "MMGKLPLGVVSPYVKMSSGGCTDPLKFYATSYCTAYGREDFKPRVGSHRGTGYKSNYRPVVFYQPHLDALDNTATGEQGCNNFQTVTSQSYRPLEVPDGTHPLPWNLHQTNSGYSREKASAVTPIKEVRKVHFDTQDYGPQAITGLEPKDAPLLHQQQNKGSLEWENAGHGPRFMTSEYNSKYLKEPSHQPDLLQKNSVGAKEETGFTEESNKNPIVFQPPSQALPGDPVLLPGRSVTKSDFLPISHPHGDEFLPVLARGSERETGFSRVNERTLNPRVPPPCPEPSSMNHWQFQSPQRMQQTNVALLGRETVGNKEPSGFSLNNPSYVRSPYDPDMDNRYLTTYNQGYFENIPKGLDREGWTRGGLQPQKPGGYALNQPVTRLEATPTPTESLRRLHPHLGRTLISVDPFYRTAPPSGHVSRFTAPN", "length": 428, "header": "sp|Q2T9T0-1|SAXO4_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 4 OS=Bos taurus OX=9913 GN=SAXO4 PE=1 SV=1 CANONICAL=Q2T9T0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 389, "start_aa": "Thr", "end_pos": 389, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr389", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 391, "start_aa": "Thr", "end_pos": 391, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr391", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:506337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506337", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T0", "url": "https://www.uniprot.org/uniprotkb/Q2T9T0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9T0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 428, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9T0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9T0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 389, 391 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2T9T5-1", "uniprot_ac": "Q2T9T5", "uniprot_id": "LRC61_BOVIN", "mass": { "chemical_mass": 28012.0, "monoisotopic_mass": 28012.0 }, "refseq": { "ac": "NP_001069899", "name": "leucine-rich repeat-containing protein 61", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069899" }, "gene_names": [ { "name": "LRRC61", "type": "recommended", "evidence": [ { "id": "Q2T9T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5" } ] }, { "name": "LRRC61", "type": "synonym", "evidence": [ { "id": "NP_001069899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069899" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 61", "type": "recommended", "evidence": [ { "id": "Q2T9T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 61", "type": "synonym", "evidence": [ { "id": "NP_001069899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069899" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9T5", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC61", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5", "locus": { "chromosome": "4", "start_pos": 112752952, "end_pos": 112745938, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031059", "url": "https://www.ensembl.org/id/ENSBTAG00000031059" } ] } } ], "crossref": [ { "id": "Q2T9T5", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9T5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031059", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031059", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616659", "url": "https://www.ncbi.nlm.nih.gov/gene/616659", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616659", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616659", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YWESWPT", "url": "https://omabrowser.org/oma/group/YWESWPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR18849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18849:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18849:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069899", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9T5", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9T5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRGEKSGEADGVRVTPQLLKARSGEFALESILLLKLRGLGLVGLGCLGDCLGLEWLDLSGNALTQLGPLASLRQLAVLNVADNRLTGLEPLAACENLQCLNAAGNLLAGPAQLQCLAGLRGLERLRLRDPLARLSNPLCASPCYWASVRELLPGLKVLDGERVSGRGSDFYQLCRDLDSSLSPDPGAPGPRPMEAQPWVEPGYWEALPPRSSSILEEACRQFQDTLQECHDLDRQAWDSLAQAMRALSPAGATAASFVF", "length": 261, "header": "sp|Q2T9T5-1|LRC61_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 61 OS=Bos taurus OX=9913 GN=LRRC61 PE=2 SV=1 CANONICAL=Q2T9T5-1" }, "isoforms": [ { "isoform_ac": "Q2T9T5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5/entry#Q2T9T5-1", "sequence": { "sequence": "MEPRGEKSGEADGVRVTPQLLKARSGEFALESILLLKLRGLGLVGLGCLGDCLGLEWLDLSGNALTQLGPLASLRQLAVLNVADNRLTGLEPLAACENLQCLNAAGNLLAGPAQLQCLAGLRGLERLRLRDPLARLSNPLCASPCYWASVRELLPGLKVLDGERVSGRGSDFYQLCRDLDSSLSPDPGAPGPRPMEAQPWVEPGYWEALPPRSSSILEEACRQFQDTLQECHDLDRQAWDSLAQAMRALSPAGATAASFVF", "length": 261, "header": "sp|Q2T9T5-1|LRC61_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 61 OS=Bos taurus OX=9913 GN=LRRC61 PE=2 SV=1 CANONICAL=Q2T9T5-1" }, "locus": { "chromosome": "4", "start_pos": 112748924, "end_pos": 112748142, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043967.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043967.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041497.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041497.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 17, "start_aa": "Thr", "end_pos": 17, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616659", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H8K1-1", "protein_name": "Leucine-rich repeat-containing protein 61", "gene_name": "Lrrc61", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPSGEKPGEAEGLSITPQLLKSRSGEFALDSILLLKLRGLGLVDLGCLGECLSLEWLDLSGNALTHLGPLAPLNQLAVLNVSNNRLTGLEPLAACENLQSLNVAGNLLATPGQLQCLAGLQGLEYLRLRDPLARLSNPLCATPSYWAVVRELLPGLKVIDGERVSGRGSDLYQLCRDLDSSLRRSSSPGPIAIEAQLWVDPDYWESCPMQSSSILEEACRQFQDTLQECLDLDRQAGDSLAQAQQALSAAEATSSVVF", "length": 259 }, "evidence": [ { "id": "Q2T9T5", "url": "https://omabrowser.org/oma/group/Q2T9T5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1ADD4-1", "protein_name": "Leucine rich repeat containing 61", "gene_name": "LRRC61", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "METQTEKGEDGEGTRITAQLLKASTGEFALESILLLKLRGRGIADLGCLGDCTNLEWLDLSGNAISQLGPLAGLKALAVLNLSRNRISSLEPLSSCESLQSLNLAGNQVSSLQQLRCLAGLRRLESLRLRDALGQLSNPVCATAAYRAALPELLPGLRDIDGERVSGRGSELFQLCQDLDSSLGHGPGPAAPRAAQPWVQAGFWEPPPLRRSSIVEEAYRQFGEALRECRELGRRADDTIAQAERALSGRADPGSYVF", "length": 258 }, "evidence": [ { "id": "Q2T9T5", "url": "https://omabrowser.org/oma/group/Q2T9T5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZA60-1", "protein_name": "Leucine-rich repeat-containing protein 61", "gene_name": "Lrrc61", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPPGEKPGEAEALIITPQLLKSHSGEFALDSILLLKLRGLGVVDLGCLGECLNLEWLDLSGNALTHLGPLASLHQLAVLNVSNNRLTGLEPLAACENLQSLNAAGNLLTNPGQLQCLAGLQGLEHLRLRDPLARLSNPLCVNPSYWAAVRELLPGLKVIDGERVSGRGSELYQLCRDLDSSLRSSTSLGPRAIEVQPWVEPGYWESWPIRSSSILEEACRQFQDTLQECLDLDRQASDSLAQAQQALRPAKTTSSFVF", "length": 259 }, "evidence": [ { "id": "Q2T9T5", "url": "https://omabrowser.org/oma/group/Q2T9T5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R2R5-1", "protein_name": "Leucine-rich repeat-containing protein 61", "gene_name": "Lrrc61", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPPGEKPGEAEALSITPQLLKSHSGEFALDSILLLKLRGLGVVDLGCLGECLNLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLAACENLQSLNAAGNLLTTPGQLQCLAGLQALEHLRLRDPLARLSNPLCANASYWAVVRELLPGLKVIDGERVSGRGSELYQLCRDLDSSLRSGSSPGPRAIEAQPWVEPGYWESWPIRSSSILEEACRQFQDTLQECLDLDRQASDSLAQAQQALSPAETTSSFVF", "length": 259 }, "evidence": [ { "id": "Q2T9T5", "url": "https://omabrowser.org/oma/group/Q2T9T5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BV99-1", "protein_name": "Leucine-rich repeat-containing protein 61", "gene_name": "LRRC61", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDSLAQAEQVLSSAGPTSSFVF", "length": 259 }, "evidence": [ { "id": "Q2T9T5", "url": "https://omabrowser.org/oma/group/Q2T9T5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T5", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T5", "url": "https://www.uniprot.org/uniprotkb/Q2T9T5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9T5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9T5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9T5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 17 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9T9-1", "uniprot_ac": "Q2T9T9", "uniprot_id": "FBXW9_BOVIN", "mass": { "chemical_mass": 50654.0, "monoisotopic_mass": 50654.0 }, "refseq": { "ac": "NP_001033240", "name": "F-box/WD repeat-containing protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033240" }, "gene_names": [ { "name": "FBXW9", "type": "recommended", "evidence": [ { "id": "Q2T9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9" } ] }, { "name": "FBXW9", "type": "synonym", "evidence": [ { "id": "NP_001033240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033240" } ] } ], "protein_names": [ { "name": "F-box/WD repeat-containing protein 9", "type": "recommended", "evidence": [ { "id": "Q2T9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9/entry#names_and_taxonomy" } ] }, { "name": "F-box and WD-40 domain-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033240" }, { "id": "Q2T9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9/entry#names_and_taxonomy" } ] }, { "name": "F-box/WD repeat-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033240" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9T9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXW9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9", "locus": { "chromosome": "7", "start_pos": 12813796, "end_pos": 12806967, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020924", "url": "https://www.ensembl.org/id/ENSBTAG00000020924" } ] } } ], "crossref": [ { "id": "Q2T9T9", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "532538", "url": "https://www.ncbi.nlm.nih.gov/gene/532538", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532538", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532538", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9T9", "url": "https://www.orthodb.org/?gene=Q2T9T9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19855:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19855:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033240", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9T9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9T9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELPPGPRDDPHAWDDDSDPELEPDTDAQAEAYVARLLSPPKLGLAPPRAPPLPAPTVSFGSLEPRAASKGPTVAVPGLLSLPPELLLEICAYLDARLVLHVLPRVCHALRDLVRDRVTWRLRAQRRVRAPYPVVEEEDFDWPTACIELEQHLSRWADDGRRAEYFCLADGHFASIDSVLLLQGGTLCLSGSRDRNVNLWDLQQLGVEPSRVLVKTLGTQKNSTHKGWVWSLAALDHRVCSGSWDSTVKLWDMAADGQQFGEIKGKAAVLCLSYRPDILVTGTYDKKVTVYDPRVGPALLKSRRLHSSAVLALLADDRHIISGSEDHTLVVFDRRANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRSGCFQLVRSFDVGHRSQITGIKHSLGALYTTSTDKTIRVHVPTDPPRTICTRSHHNVLNGICAEGNLVVAASGGLSLEVWRLQA", "length": 458, "header": "sp|Q2T9T9-1|FBXW9_BOVIN Isoform 1 of F-box/WD repeat-containing protein 9 OS=Bos taurus OX=9913 GN=FBXW9 PE=2 SV=1 CANONICAL=Q2T9T9-1" }, "isoforms": [ { "isoform_ac": "Q2T9T9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9/entry#Q2T9T9-1", "sequence": { "sequence": "MELPPGPRDDPHAWDDDSDPELEPDTDAQAEAYVARLLSPPKLGLAPPRAPPLPAPTVSFGSLEPRAASKGPTVAVPGLLSLPPELLLEICAYLDARLVLHVLPRVCHALRDLVRDRVTWRLRAQRRVRAPYPVVEEEDFDWPTACIELEQHLSRWADDGRRAEYFCLADGHFASIDSVLLLQGGTLCLSGSRDRNVNLWDLQQLGVEPSRVLVKTLGTQKNSTHKGWVWSLAALDHRVCSGSWDSTVKLWDMAADGQQFGEIKGKAAVLCLSYRPDILVTGTYDKKVTVYDPRVGPALLKSRRLHSSAVLALLADDRHIISGSEDHTLVVFDRRANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRSGCFQLVRSFDVGHRSQITGIKHSLGALYTTSTDKTIRVHVPTDPPRTICTRSHHNVLNGICAEGNLVVAASGGLSLEVWRLQA", "length": 458, "header": "sp|Q2T9T9-1|FBXW9_BOVIN Isoform 1 of F-box/WD repeat-containing protein 9 OS=Bos taurus OX=9913 GN=FBXW9 PE=2 SV=1 CANONICAL=Q2T9T9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 57, "start_aa": "Thr", "end_pos": 57, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr57", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 73, "start_aa": "Thr", "end_pos": 73, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr73", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9" } ], "site_lbl": "Ser18" }, { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9T9", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9" } ], "site_lbl": "Ser59" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532538", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532538", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9T9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 458, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9T9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9T9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9T9" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 76, "end_pos": 123, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 57, 73 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 18, 59 ], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 373, "end_pos": 375 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9U5-1", "uniprot_ac": "Q2T9U5", "uniprot_id": "REXO5_BOVIN", "mass": { "chemical_mass": 88254.0, "monoisotopic_mass": 88254.0 }, "refseq": { "ac": "NP_001033243", "name": "RNA exonuclease 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033243" }, "gene_names": [ { "name": "REXO5", "type": "recommended", "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ] }, { "name": "REXO5", "type": "synonym", "evidence": [ { "id": "NP_001033243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033243" } ] } ], "protein_names": [ { "name": "RNA exonuclease 5", "type": "recommended", "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5/entry#names_and_taxonomy" } ] }, { "name": "Putative RNA exonuclease NEF-sp", "type": "synonym", "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5/entry#names_and_taxonomy" } ] }, { "name": "RNA exonuclease 5", "type": "synonym", "evidence": [ { "id": "NP_001033243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033243" } ] }, { "name": "putative RNA exonuclease NEF-sp", "type": "synonym", "evidence": [ { "id": "NP_001033243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033243" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REXO5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5", "locus": { "chromosome": "25", "start_pos": 18617436, "end_pos": 18556283, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006449", "url": "https://www.ensembl.org/id/ENSBTAG00000006449" } ] } } ], "crossref": [ { "id": "Q2T9U5", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9U5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006449", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006449", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06145", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06145", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532864", "url": "https://www.ncbi.nlm.nih.gov/gene/532864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532864", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532864", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHICIQY", "url": "https://omabrowser.org/oma/group/PHICIQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9U5", "url": "https://www.orthodb.org/?gene=Q2T9U5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801:SF82", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801:SF82", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00929", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00929", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033243", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9U5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPERKRSGSTLKKGRKRRLIPSKVVGAAEATRSHWDLEEKQQPIAKKARLSTVLFAENCEVTHGQLCELLKYAVLGKSSFPKPSWCQLFHQNHLKNVVVFILQGLSQLHFYKFYLEFGFLRKAFKHKFRMPPPSSDFLADIIGLQKKQIIGNLPKAMEGSLPFASSKVSINLQKDPIIQKYGFKKVGLTRCLLTKEEMKTYHFPLQGFLDCENFVPTKCNGSVTDNSPLFGLDCEMCLTSKGRELTRISLVAEGGGCVMDELVKPDNKIVDYLTSFSGITKKILNPVTTKLKDVQRRLKILLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKAILGKDIQCPDRLGHDATEDARTTLELARYFLKYGPKKIAELNLEALFSYQESQEPRNTAEGVQRLNTSVLECLDSVGQKLLFLTQEADASALSSSKNCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFEPFSPNLTQEMNKRIKIKWTEMSTVYAGPFNKNCNLSALKRLFKSFGPVQLMTLVLETHQPHLCIQYEVLEAAQLAIESLDGVLVEGSCIKVQRPVTELTLDCDTLVNELEQDSENRGTIYLSGVSETFKEHLLQHCSIFLGLEAMILPKDLKSGKQKGYCFLRFKTFGSAQRALNILTGKDWKLRGRHALTPRHLHAWLRGLARESRLPGVRVIPPPSEQEAWQMLNVDHPKIAAWHWGRKIEKLYHNLCPGTLCLILLPGTKSTHGSLSGLGLMGIKDEEESTIPQTCVCESAHHLPGVIS", "length": 783, "header": "sp|Q2T9U5-1|REXO5_BOVIN Isoform 1 of RNA exonuclease 5 OS=Bos taurus OX=9913 GN=REXO5 PE=2 SV=1 CANONICAL=Q2T9U5-1" }, "isoforms": [ { "isoform_ac": "Q2T9U5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5/entry#Q2T9U5-1", "sequence": { "sequence": "MEPERKRSGSTLKKGRKRRLIPSKVVGAAEATRSHWDLEEKQQPIAKKARLSTVLFAENCEVTHGQLCELLKYAVLGKSSFPKPSWCQLFHQNHLKNVVVFILQGLSQLHFYKFYLEFGFLRKAFKHKFRMPPPSSDFLADIIGLQKKQIIGNLPKAMEGSLPFASSKVSINLQKDPIIQKYGFKKVGLTRCLLTKEEMKTYHFPLQGFLDCENFVPTKCNGSVTDNSPLFGLDCEMCLTSKGRELTRISLVAEGGGCVMDELVKPDNKIVDYLTSFSGITKKILNPVTTKLKDVQRRLKILLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKAILGKDIQCPDRLGHDATEDARTTLELARYFLKYGPKKIAELNLEALFSYQESQEPRNTAEGVQRLNTSVLECLDSVGQKLLFLTQEADASALSSSKNCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFEPFSPNLTQEMNKRIKIKWTEMSTVYAGPFNKNCNLSALKRLFKSFGPVQLMTLVLETHQPHLCIQYEVLEAAQLAIESLDGVLVEGSCIKVQRPVTELTLDCDTLVNELEQDSENRGTIYLSGVSETFKEHLLQHCSIFLGLEAMILPKDLKSGKQKGYCFLRFKTFGSAQRALNILTGKDWKLRGRHALTPRHLHAWLRGLARESRLPGVRVIPPPSEQEAWQMLNVDHPKIAAWHWGRKIEKLYHNLCPGTLCLILLPGTKSTHGSLSGLGLMGIKDEEESTIPQTCVCESAHHLPGVIS", "length": 783, "header": "sp|Q2T9U5-1|REXO5_BOVIN Isoform 1 of RNA exonuclease 5 OS=Bos taurus OX=9913 GN=REXO5 PE=2 SV=1 CANONICAL=Q2T9U5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532864", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532864", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A111-1", "protein_name": "RNA exonuclease 5", "gene_name": "REXO5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPERERTGRAPKRGKKRRRVANQLVGAAEAMRARWDLEERQQPEAKKARLSTILFAENCEITHGQLCELLKYAVLGKSSVPKPSWCQLFHQNHLNNVVVFILQGMSQLHFYRFYLEFGFLRKAFRHKFRLPPPSSDFLADIIGLQRKKKIGDLSKTMEGSLPSVSSKVSISPQNDPIIQKYGSKKVGLTRCLLTKEEMKAYHFPLQGFPDCENFVPTKCNGSITDNSPLFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPDNKIVDYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKTILGKDIQCPDRLGHDAIEDARTTLELARYFLKYGPKKIAELNLETVASHQELQAAGQEPRNTAEVVQQLNAGVLECLDSLGQKLLFLTREADASELSSSKTCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFEPFSPNLTEEMNKRMLIKWTEMSTVYAGPFSKNCNLRALKKLFKSFGPVRSMTLVLETHQPHLCIQYEVLEAAQLAIESLDGILVEGACIKVQRPVTELTLDCDTLVNELEHDSENRGTIYLSGVRETFKEHLLQRSSLFLGLEAVILPKDLKSGKQKKYCFLRFKTFGRAQRALDILTGKDWKLKGRHALTPRHLQAWLRGLPLESRRPPGLRVIPPPSEQEALQMLKVDHPKIAAWRWGRKIGKLYHSLCPGTLCLILLPGTKRQKLSSLLICCSTHGSLSGLGLMGIKDEEESSTPNMCL", "length": 787 }, "evidence": [ { "id": "Q2T9U5", "url": "https://omabrowser.org/oma/group/Q2T9U5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z4K9-1", "protein_name": "RNA exonuclease 5", "gene_name": "REXO5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLSGGVNGCKRPAGEDAEGLRAGGKRSRAGRREAKEKSSHLCAALLGEDCEISPEQLHELLQYAALGKHHNAAQPSWCHIYHQSRLAGVVVIVLHEMSQLHFYKFYLQFKHLRKVFQHRFTLPPPSANFLASLCGEGSSLNPQGTAQGLISTGAECIPKSSGLQCDPIIRKYGKEKRGLTSYTLTSEELKKNDYPMRDSPGCKGYMYTECDLQRTDSSPLFGLDCEMCLTARGNEVVRVSLVDAEGQCLLNELVKPESVIVNYCTRYSGVTRKMLLPVKTRLPDIQTRLKKILPHDAVLVGHSLNADLQALQMIHPSVIDTSLLFARNEGRRFKLKFLAKAVLGKEIQCEQRLGHDPAEDARAALELAQFFIKKGPVKVAELNLEMLLAAERQTEVLPKKSVMQPQRCGVQKQLNDTPHLSKPCFLACLQGMGQKPLLLGRQELDSSGFCQSDLSASNKQILQRALEDVPLSTFSIIQFSLDPEYVASHRLAGFCEKVRNKLTDMLTIYAGPFEEDFCLKSVKKEFGKCGPIHSLTVVSETYQPYVCIQYGVLEAAQLAVESLNGAEVAGSCIKVQRPITAATLDCDVLIKELELDIENEGVIYVAGIKKSLTETDLQEEFSPLKDLETLFLPKDLQSGKHSTCCFLKFQKSQSAADALEAINGWAVKGSTLRSRHALASGHLWRWIWQMNHSSEKQGGNSLSEKMAPLSDSEQDVKKKVKKLDHHIKKLYRSLQDNTLCVVLFPGTNSIHGSQSGLGMMGIKDDGGSSAC", "length": 773 }, "evidence": [ { "id": "Q2T9U5", "url": "https://omabrowser.org/oma/group/Q2T9U5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1A5R7-1", "protein_name": "RNA exonuclease 5", "gene_name": "Rexo5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELEEEENPRKRKETPNSALTTELDRPSWDVQDPEPQAKKARLSTILFTDNCEVTHRQLCELLKYAILGKSTLPKPSWCQLLHQKQLNNVVVFILKGMSQLHFYRFYLEFRFLRKTFRHKFSLPPPTSSFLFDIIGLQKKKSARGCPRTVEGPLISATLKSSIDLQNDPIIQKYGYKNVSLTRCLLTKEEMKTFHFPLQGSPNCENFILLKYSGFITDSSPLFGLDCEVCLTSMGKELTRISLVAEGGYCLMDELVKPDFKILDYLTSFSGITKEILNPVTTKLKDVQKLLRELLPPDAVLVGHCLDLDLRVLKIIHPYVIDTSLLYIGKQGRRFKLTFLAKVILGKDIQCPNKLGHDGIEDARTALELVQYFLKYGPKKIAEFNLEALAANQEQGNKEGATHMRSVLECLDSMGQKLLFLTQDIDELSSYRNCQTVKCSSNKEVLEQARVEVPLFPFNIVQFSFRPFPPLFAEEMKNNMKTRWTEMSTIYAGPFSKDCNVGSLKKVFSSLGPVQSITLVLETYRPYFSIQYELLEAAQLAIETMNGTILEGSCIRVHRLLTELTLECDTLVRELEQDSENQGTIYVAGIGETFKEHLLEQSNLFPDLEAVILPKELKSRKQKNYCFLKFKTFNSAQVALEVLKGKDWKLKGRNALTSRHLQAWLKNIHPEPSMPMGLRIVPPLLERHIFRTLKANHPKIVAWRWSRRIEKLYHSLSPGTFCLILLPGTKNTFGSHPGLGLMKIKEEEGGDTLL", "length": 754 }, "evidence": [ { "id": "Q2T9U5", "url": "https://omabrowser.org/oma/group/Q2T9U5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3YW29-1", "protein_name": "RNA exonuclease 5", "gene_name": "Rexo5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQEKEEANSRKRKEAPNSSASATERDGPPSHIQDREPQAKKARLSTILFTDNCEVTHRQLCELLKYAVLGKSAVPKPSWCQLSHQKQLNNVVVFILKGMSQLHFYRFYLEFRFLRKTFRHKFSLPSPTSSFLFDIIGLQKKKSARSFRRTVEGPLISATLRSSIDLQNDPIIQKYGYKNVGLTKCLLTKEEMKTFHFPLPGSPNYENFILTKYTGFITDSSPLFGLDCEVCLTSMGKELTRISLVTEGGYCLIDELVKPDLKILDYLTSFTGITKEILNPVTTKLKDVQKLLRELLPPDAVLVGHCLDLDLRVLKMIHPYVIDTSLLYAGKQGRRFKLTFLARVILGKDIQCPNKLGRDGIEDARAALELLQYFLKYGPKKIAEFNLEALAANQEQGDKEEAAHMRCVLKCLESMGQKLLFLTQDINELSSYRNCQTIKCSSNKKVLEQARVEVPLFPFNIVEFSFQPFPPLFAEEMKNSMKTKWTQMSTVYAGPFSKDCNVGALKKVFSSLGPVHSITLVLETYRPYFSIQYEVLEAAQLALETMNGSLLEGSCIRVRRLVTELTLECDTLVRELEQDSENQGTIYVAGIGETFKEHLLEQSNLFPDLEAVILPKEVKSRKQKNYCFLKFKTVNSAQVALEILKGKDWKLKGRNALTPRHLQAWLKDIHPEPAMPMGLRIVPPLMERHIFRTRKVNHPKIVAWRWSRKIEKLYHSLSPGTFCLILMPGTKNAFGSHPGLGLMKIKEEEESDTPGVRV", "length": 759 }, "evidence": [ { "id": "Q2T9U5", "url": "https://omabrowser.org/oma/group/Q2T9U5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96IC2-1", "protein_name": "RNA exonuclease 5", "gene_name": "REXO5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCEVTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCLRKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKYGSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDRLGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNTSVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLETRQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQGSIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNILTGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAWRWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS", "length": 774 }, "evidence": [ { "id": "Q2T9U5", "url": "https://omabrowser.org/oma/group/Q2T9U5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA 3'-end processing", "id": "GO:0031125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031125", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ], "pmid": "" }, { "name": "exonuclease activity", "id": "GO:0004527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004527", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U5", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9U5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 783, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9U5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9U5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 1", "eco_id": "ECO_0000255", "start_pos": 503, "end_pos": 577, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2T9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U5" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 2", "eco_id": "ECO_0000255", "start_pos": 598, "end_pos": 677, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 221, "end_pos": 223 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 515, "end_pos": 517 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9V7-1", "uniprot_ac": "Q2T9V7", "uniprot_id": "PREY_BOVIN", "mass": { "chemical_mass": 12620.0, "monoisotopic_mass": 12620.0 }, "refseq": {}, "gene_names": [ { "name": "PREY", "type": "recommended", "evidence": [ { "id": "Q2T9V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7" } ] } ], "protein_names": [ { "name": "Protein preY, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2T9V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9V7", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PREY", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7", "locus": {} } ], "crossref": [ { "id": "Q2T9V7", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9V7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33505:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33505:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2T9V7", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9V7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSGVCARLASALRGTRAPPSAVALRCLHASSSRPSADKRDRTEKPPRAFDQALLEFLVCPLSKKPLRYEASTNELINEELGIAYPIIDGIPNMIPQAARMTHQNKKQEEVEQH", "length": 114, "header": "sp|Q2T9V7-1|PREY_BOVIN Isoform 1 of Protein preY, mitochondrial OS=Bos taurus OX=9913 GN=PREY PE=3 SV=1 CANONICAL=Q2T9V7-1" }, "isoforms": [ { "isoform_ac": "Q2T9V7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7/entry#Q2T9V7-1", "sequence": { "sequence": "MLSGVCARLASALRGTRAPPSAVALRCLHASSSRPSADKRDRTEKPPRAFDQALLEFLVCPLSKKPLRYEASTNELINEELGIAYPIIDGIPNMIPQAARMTHQNKKQEEVEQH", "length": 114, "header": "sp|Q2T9V7-1|PREY_BOVIN Isoform 1 of Protein preY, mitochondrial OS=Bos taurus OX=9913 GN=PREY PE=3 SV=1 CANONICAL=Q2T9V7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V7", "url": "https://www.uniprot.org/uniprotkb/Q2T9V7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9V7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 114, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9V7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9V7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W6-1", "uniprot_ac": "Q2T9W6", "uniprot_id": "LRRF2_BOVIN", "mass": { "chemical_mass": 45494.0, "monoisotopic_mass": 45494.0 }, "refseq": { "ac": "NP_001033159", "name": "leucine-rich repeat flightless-interacting protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159" }, "gene_names": [ { "name": "LRRFIP2", "type": "recommended", "evidence": [ { "id": "Q2T9W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ] }, { "name": "LRRFIP2", "type": "synonym", "evidence": [ { "id": "NP_001033159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat flightless-interacting protein 2", "type": "recommended", "evidence": [ { "id": "Q2T9W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6/entry#names_and_taxonomy" } ] }, { "name": "LRR FLII-interacting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001033159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159" }, { "id": "Q2T9W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6/entry#names_and_taxonomy" } ] }, { "name": "leucine rich repeat (in FLII) interacting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001033159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159" } ] }, { "name": "leucine-rich repeat flightless-interacting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001033159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159" } ] } ], "function": [ { "annotation": "May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRFIP2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6", "locus": { "chromosome": "22", "start_pos": 10455986, "end_pos": 10347060, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016760", "url": "https://www.ensembl.org/id/ENSBTAG00000016760" } ] } } ], "crossref": [ { "id": "Q2T9W6", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "510368", "url": "https://www.ncbi.nlm.nih.gov/gene/510368", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510368", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510368", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9W6", "url": "https://www.orthodb.org/?gene=Q2T9W6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19212", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19212", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19212:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19212:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09738", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09738", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033159", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIDREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRVSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 400, "header": "sp|Q2T9W6-1|LRRF2_BOVIN Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=2 SV=1 CANONICAL=Q2T9W6-1" }, "isoforms": [ { "isoform_ac": "Q2T9W6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6/entry#Q2T9W6-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIDREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRVSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 400, "header": "sp|Q2T9W6-1|LRRF2_BOVIN Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=2 SV=1 CANONICAL=Q2T9W6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 100, "end_pos": 100, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser100" }, { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser101" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser18" }, { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser77" }, { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser80" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser88" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser92" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Ser96" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "site_lbl": "Thr99" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510368", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510368", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W6", "url": "https://www.uniprot.org/uniprotkb/Q2T9W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 18, 77, 80, 88, 92, 96, 99, 100, 101 ], "sequon_annotation_sites": [ { "start_pos": 292, "end_pos": 294 }, { "start_pos": 392, "end_pos": 394 }, { "start_pos": 71, "end_pos": 73 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W9-1", "uniprot_ac": "Q2T9W9", "uniprot_id": "CAAP1_BOVIN", "mass": { "chemical_mass": 38487.0, "monoisotopic_mass": 38487.0 }, "refseq": { "ac": "NP_001033209", "name": "caspase activity and apoptosis inhibitor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" }, "gene_names": [ { "name": "CAAP1", "type": "recommended", "evidence": [ { "id": "Q2T9W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ] }, { "name": "C8H9orf82", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] }, { "name": "C9orf82", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] }, { "name": "CAAP1", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] }, { "name": "CAAP", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" }, { "id": "Q2T9W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ] } ], "protein_names": [ { "name": "Caspase activity and apoptosis inhibitor 1", "type": "recommended", "evidence": [ { "id": "Q2T9W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9/entry#names_and_taxonomy" } ] }, { "name": "CAAP", "type": "synonym", "evidence": [ { "id": "Q2T9W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9/entry#names_and_taxonomy" } ] }, { "name": "Conserved anti-apoptotic protein", "type": "synonym", "evidence": [ { "id": "Q2T9W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9/entry#names_and_taxonomy" } ] }, { "name": "caspase activity and apoptosis inhibitor 1", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] }, { "name": "conserved anti-apoptotic protein", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] }, { "name": "uncharacterized protein C9orf82 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209" } ] } ], "function": [ { "annotation": "Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAAP1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9", "locus": { "chromosome": "8", "start_pos": 17402867, "end_pos": 17332244, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001223", "url": "https://www.ensembl.org/id/ENSBTAG00000001223" } ] } } ], "crossref": [ { "id": "Q2T9W9", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001223", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001223", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515858", "url": "https://www.ncbi.nlm.nih.gov/gene/515858", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515858", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515858", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QVPEKKD", "url": "https://omabrowser.org/oma/group/QVPEKKD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9W9", "url": "https://www.orthodb.org/?gene=Q2T9W9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14740:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14740:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGKKSSREKRRKRSGQEAAAALAAPDLVPAVGGSGSGSTSGCGSASGCGSVTCCGNTSVSGSVTGGGSGGSCWGGSSVERGERRKRRSTDSSSSVSGSLQQEAKYLLPPLEKELFLAEHSDLEEGGLDLTVALKPVSFYISDKKEMLRQCFCIIGEKKLQKMLPDVLKNCSIEEIKRLCQEQLELLSEKKILKILEGDNGMDSEMEEEADDGSKMVSDVVNQQDSCVDSTSSLRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEVPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPKEPKAATLTVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA", "length": 362, "header": "sp|Q2T9W9-1|CAAP1_BOVIN Isoform 1 of Caspase activity and apoptosis inhibitor 1 OS=Bos taurus OX=9913 GN=CAAP1 PE=2 SV=1 CANONICAL=Q2T9W9-1" }, "isoforms": [ { "isoform_ac": "Q2T9W9-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9/entry#Q2T9W9-1", "sequence": { "sequence": "MTGKKSSREKRRKRSGQEAAAALAAPDLVPAVGGSGSGSTSGCGSASGCGSVTCCGNTSVSGSVTGGGSGGSCWGGSSVERGERRKRRSTDSSSSVSGSLQQEAKYLLPPLEKELFLAEHSDLEEGGLDLTVALKPVSFYISDKKEMLRQCFCIIGEKKLQKMLPDVLKNCSIEEIKRLCQEQLELLSEKKILKILEGDNGMDSEMEEEADDGSKMVSDVVNQQDSCVDSTSSLRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEVPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPKEPKAATLTVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA", "length": 362, "header": "sp|Q2T9W9-1|CAAP1_BOVIN Isoform 1 of Caspase activity and apoptosis inhibitor 1 OS=Bos taurus OX=9913 GN=CAAP1 PE=2 SV=1 CANONICAL=Q2T9W9-1" }, "locus": { "chromosome": "8", "start_pos": 17402857, "end_pos": 17332303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001617.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001617.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001617.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001617.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 121, "end_pos": 121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "site_lbl": "Ser121" }, { "start_pos": 204, "end_pos": 204, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "site_lbl": "Ser204" }, { "start_pos": 313, "end_pos": 313, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "site_lbl": "Ser313" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "site_lbl": "Ser89" }, { "start_pos": 90, "end_pos": 90, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "site_lbl": "Thr90" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515858", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515858", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AC58FX91-1", "protein_name": "Caspase activity and apoptosis inhibitor 1 isoform X1", "gene_name": "caap1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQEGKKREKEKKRSHCDRELDDGQMKRRKSGPSMEECRQPLEPPEGPQEPSELEDGGLDLSRSFKPISGYMQERREMLEQCFSVLGENKLQEMLPDGLKDCSLNEIKKLCWDQLLQISDIHLLEILDGKELSVLAAPEQKSCTDSQQDSNVDSTSSLRDNPDTEEKQGKINTYQRSTPQFPARFVCLCFCVCAFVCFIYLCVLFVCVVCVSVFVCFIYLCVLFICACVCVCVFVCAFVCLSICVCMCVCLCVFVCAFVCVMFVCVYVCVCVSVCAFVCFIYLCVCVCLFLCVLLCFVCVCVCFCVCFLFLSICVCACVYVCVCVFVCACVFYLCVCVCVLLCVLFVCVCVCVCVCVCVCVLLCVLCVCVCVCVCVLCVLFVFLSICVLFVCVRVCLCFCVCLCVLFVCVCVCAFVCFVCVCVCVCVCVCVCFVCAFCFICVCACVSVCIFVCVCVWGGVVNVCICFFHLHVCV", "length": 473 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BSD0-1", "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "CAAP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGRKSSKEKKRRRSRSCCPDGAAGGDRKRRSAESGRAAPEEEKCNVPSGEKVEEPEQFSDVEEGGLDLSVSLKPVSFYIADKKEMLQQCFCVIGEKKLQKMLPDILKSCSMDEIKRLCLEQLEMLSEKKLLKILEGKSGADSDTDEDGDGEDKTGGESVSQQDNSIDSTSSLREDKLEGQESKQGKGEDSDVLSINADAYDSDIEGPCDEEGSPDMQEDTVRSGAGQIDDLQKDIEKSVNEILGLAESSPKESKAASLAVPPLEDVQPSAQQLELLELEMRARAIKALMKAGDVKKQP", "length": 299 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SP80-1", "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "CAAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGKKSSREKRRKRSGQEAAAALAAPELVPAVAGSGSGSTSGCGSASGCGSVTCCGNTSFSGSVTGTGSGGSCWGGSGVERSERRKRRSTDSSSSVSGSLQQEAKYLLPTLDKELFLAEHSDLEEGGLDLTVALKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNAVDSDMEEEADDGSKMGSELVSQQDICTDSTSSLKENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEVPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPKEPKAATLTVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA", "length": 362 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V6Y7-1", "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "Caap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGKKSSREKRRKRSGQEAAAALAAPDLVPVLSGSAGGCGSVGCCGVAGGGTSVAGGAERSERRKRRSTDSSSSVSGSLQQETKYLLPSLEKELILAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEQKLQKMLPDVLKNCSVEEIKKLCQEQLELLSEKKILKILEGDNGLDSDMEEEADRGSKVAPDLISQQDTCVDSTSSLRENKQPEGLESKQGKGEDSDVLSINADAYDSDIEGPSNEEAAASATAAPTATAVATAASASEVPGGTVQSEAAQIDDLERDIEKSVNEILGLVESSPKEPKAAILTVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPV", "length": 358 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VDY9-1", "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "Caap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGKKSSREKRRKRSGQEAAASLAAPDLVPVLSGSAGGCGSGGCCGVAGGGTSVAGGAERSERRKRRSTDSSSSVSGSLQQETKYLLPSLEKELFLAEHSDLEEGGLDLNVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSVEEIKKLCQEQLELLSEKQILKILEGDNGLDSDMEEEADDGCKVAPDLISQQDTCVDSTSSLRENKQPEVLESKQGKGEDSDVLSINADAYDSDIEGPSIDEAAAAATATPAATAVATAASEVPENTVQSEAGQIDDLERDIEKSVNEILGLAESSPKEPKVATLTVPPAEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPV", "length": 356 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H8G2-1", "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "CAAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRSTDSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA", "length": 361 }, "evidence": [ { "id": "Q2T9W9", "url": "https://omabrowser.org/oma/group/Q2T9W9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 362, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 89, 90, 121, 204, 313 ], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9X3-1", "uniprot_ac": "Q2T9X3", "uniprot_id": "SPRY7_BOVIN", "mass": { "chemical_mass": 21638.0, "monoisotopic_mass": 21638.0 }, "refseq": { "ac": "NP_001033295", "name": "SPRY domain-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" }, "gene_names": [ { "name": "SPRYD7", "type": "recommended", "evidence": [ { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3" } ] }, { "name": "C12H13orf1", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" } ] }, { "name": "CLLD6", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" }, { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3" } ] }, { "name": "SPRYD7", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" } ] } ], "protein_names": [ { "name": "SPRY domain-containing protein 7", "type": "recommended", "evidence": [ { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#names_and_taxonomy" } ] }, { "name": "CLL deletion region gene 6 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" }, { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#names_and_taxonomy" } ] }, { "name": "Chronic lymphocytic leukemia deletion region gene 6 protein homolog", "type": "synonym", "evidence": [ { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#names_and_taxonomy" } ] }, { "name": "SPRY domain-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" } ] }, { "name": "chronic lymphocytic leukemia deletion region gene 6 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001033295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9X3", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPRYD7", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3", "locus": { "chromosome": "12", "start_pos": 19397591, "end_pos": 19416305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018829", "url": "https://www.ensembl.org/id/ENSBTAG00000018829" } ] } } ], "crossref": [ { "id": "Q2T9X3", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9X3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018829", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018829", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12880", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12880", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615298", "url": "https://www.ncbi.nlm.nih.gov/gene/615298", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615298", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615298", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMGNEVV", "url": "https://omabrowser.org/oma/group/HMGNEVV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9X3", "url": "https://www.orthodb.org/?gene=Q2T9X3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20951:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20951:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033295", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUD2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUD2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z629", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z629", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z629-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z629-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9X3", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9X3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASVFCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196, "header": "sp|Q2T9X3-1|SPRY7_BOVIN Isoform 1 of SPRY domain-containing protein 7 OS=Bos taurus OX=9913 GN=SPRYD7 PE=2 SV=1 CANONICAL=Q2T9X3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUD2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#A0A3Q1LUD2-1", "sequence": { "sequence": "MAASVFCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYEIIIGEGTGTPLQYFCLENLMDRGAWKAAVHGVAKSWTRLKRLHFHFSLSCIGEGNGNPLQCSCLENPGDGGA", "length": 237, "header": "tr|A0A3Q1LUD2-1|A0A3Q1LUD2_BOVIN Computationally mapped isoform of SPRY domain-containing protein 7 OS=Bos taurus OX=9913 GN=SPRYD7 PE=4 SV=2 CANONICAL=Q2T9X3-1" }, "locus": { "chromosome": "12", "start_pos": 19416075, "end_pos": 19399009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066562.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066562.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060952.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060952.2" } ] } }, { "isoform_ac": "A0AAF6Z629-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#A0AAF6Z629-1", "sequence": { "sequence": "MAASVFCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 157, "header": "tr|A0AAF6Z629-1|A0AAF6Z629_BOVIN Computationally mapped isoform of SPRY domain containing 7 OS=Bos taurus OX=9913 GN=SPRYD7 PE=4 SV=1 CANONICAL=Q2T9X3-1" }, "locus": { "chromosome": "12", "start_pos": 19416075, "end_pos": 19398611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025061.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025061.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025061.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025061.4" } ] } }, { "isoform_ac": "Q2T9X3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3/entry#Q2T9X3-1", "sequence": { "sequence": "MAASVFCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196, "header": "sp|Q2T9X3-1|SPRY7_BOVIN Isoform 1 of SPRY domain-containing protein 7 OS=Bos taurus OX=9913 GN=SPRYD7 PE=2 SV=1 CANONICAL=Q2T9X3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615298", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615298", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HTD4-1", "protein_name": "SPRY domain-containing protein 7", "gene_name": "Spryd7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSASAWCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANNLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TFQ1-1", "protein_name": "SPRY domain-containing protein 7", "gene_name": "Spryd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASAWCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5M7T2-1", "protein_name": "SPRY domain-containing protein 7", "gene_name": "Spryd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASAWCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5W111-1", "protein_name": "SPRY domain-containing protein 7", "gene_name": "SPRYD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5ZHV7-1", "protein_name": "SPRY domain-containing protein 7", "gene_name": "SPRYD7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAASVFCCLRWCRDGGAGHIPLKEMPAVQLDTQRMGTDVVIVKNGRRICGTGGCLANAPLHQNKSYFEFKIQSTGIWGIGVATQKANLNQIPLGRDVHSLVMRNDGALYYNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF", "length": 196 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9VED7-1", "protein_name": "SPRY domain-containing protein", "gene_name": "Dmel\\CG7785", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFCCLRTCLNGGHIRKPTATSRLREPDVHLDAAHMGPDVILLSHQLRVTGTGGVLATAPLVQSKSYFEVKIQHGGSWSVGLATRQTDLSRKSGGGDRESWCLCSDNATRHNDREEFRPVVQSACTTQPARTSNGILNNSAAKAAGLIAIEDLQQEDLLMTTGVASSDVDIGDSLIASPQRDFPDEGDIVGVAFDHVELNFYFNGKNLEVPFRNVRGAALFPVIYVGNGAILDIILDNFSHGPPPGFERILLEQSLL", "length": 256 }, "evidence": [ { "id": "Q2T9X3", "url": "https://omabrowser.org/oma/group/Q2T9X3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9X3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9X3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9X3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X3" }, { "id": "PRU00548", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00548" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 184, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9X5-1", "uniprot_ac": "Q2T9X5", "uniprot_id": "SACDR_BOVIN", "mass": { "chemical_mass": 23438.0, "monoisotopic_mass": 23438.0 }, "refseq": { "ac": "NP_001069954", "name": "sperm acrosome developmental regulator", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" }, "gene_names": [ { "name": "SPACDR", "type": "recommended", "evidence": [ { "id": "Q2T9X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5" } ] }, { "name": "C25H7orf61", "type": "synonym", "evidence": [ { "id": "NP_001069954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" } ] }, { "name": "SPACDR", "type": "synonym", "evidence": [ { "id": "NP_001069954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" } ] } ], "protein_names": [ { "name": "Sperm acrosome developmental regulator", "type": "recommended", "evidence": [ { "id": "Q2T9X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5/entry#names_and_taxonomy" } ] }, { "name": "chromosome 25 C7orf61 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" } ] }, { "name": "sperm acrosome developmental regulator", "type": "synonym", "evidence": [ { "id": "NP_001069954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" } ] }, { "name": "uncharacterized protein C7orf61 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954" } ] } ], "function": [ { "annotation": "May play an important role in acrosome formation and nucleus shaping during spermiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5#function" }, { "database": "UniProtKB", "id": "Q8IZ16", "url": "https://www.uniprot.org/uniprotkb/Q8IZ16#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPACDR", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5", "locus": { "chromosome": "25", "start_pos": 36091628, "end_pos": 36087967, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016765", "url": "https://www.ensembl.org/id/ENSBTAG00000016765" } ] } } ], "crossref": [ { "id": "Q2T9X5", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9X5", "database": "AlphaFoldDB", "categories": [] }, { "id": "617958", "url": "https://www.ncbi.nlm.nih.gov/gene/617958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9X5", "url": "https://www.orthodb.org/?gene=Q2T9X5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR39221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39221:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39221:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069954", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9X5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVIKFFRWIWQKISRWVFFWKHKAKSVIMDHTDSKKNELKAEKAFKVSETFKLVEPPKEAKVSKMDVSPKVVDPCLLAKTTMDGAAVEAGRRRRSLLKLPQAAVKSVSMLMASALQSGWQMCSWKSSVSSTSVASQMKTRSPLESREAAMLREVYLVLWAIRKQLRQVARRQERRRRHHLRAHMGPQPDPAQGLKQDARSPL", "length": 204, "header": "sp|Q2T9X5-1|SACDR_BOVIN Isoform 1 of Sperm acrosome developmental regulator OS=Bos taurus OX=9913 GN=SPACDR PE=2 SV=1 CANONICAL=Q2T9X5-1" }, "isoforms": [ { "isoform_ac": "Q2T9X5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5/entry#Q2T9X5-1", "sequence": { "sequence": "MAVVIKFFRWIWQKISRWVFFWKHKAKSVIMDHTDSKKNELKAEKAFKVSETFKLVEPPKEAKVSKMDVSPKVVDPCLLAKTTMDGAAVEAGRRRRSLLKLPQAAVKSVSMLMASALQSGWQMCSWKSSVSSTSVASQMKTRSPLESREAAMLREVYLVLWAIRKQLRQVARRQERRRRHHLRAHMGPQPDPAQGLKQDARSPL", "length": 204, "header": "sp|Q2T9X5-1|SACDR_BOVIN Isoform 1 of Sperm acrosome developmental regulator OS=Bos taurus OX=9913 GN=SPACDR PE=2 SV=1 CANONICAL=Q2T9X5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5" } ], "site_lbl": "Ser65" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617958", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X5", "url": "https://www.uniprot.org/uniprotkb/Q2T9X5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9X5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9X5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9X5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 65 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Z7-1", "uniprot_ac": "Q2T9Z7", "uniprot_id": "KLHL9_BOVIN", "mass": { "chemical_mass": 69403.0, "monoisotopic_mass": 69403.0 }, "refseq": { "ac": "NP_001070424", "name": "kelch-like protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070424" }, "gene_names": [ { "name": "KLHL9", "type": "recommended", "evidence": [ { "id": "Q2T9Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ] }, { "name": "KLHL9", "type": "synonym", "evidence": [ { "id": "NP_001070424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070424" } ] } ], "protein_names": [ { "name": "Kelch-like protein 9", "type": "recommended", "evidence": [ { "id": "Q2T9Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 9", "type": "synonym", "evidence": [ { "id": "NP_001070424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070424" } ] }, { "name": "kelch-like protein 9", "type": "synonym", "evidence": [ { "id": "NP_001070424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070424" } ] } ], "function": [ { "annotation": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL9", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7", "locus": { "chromosome": "8", "start_pos": 22904861, "end_pos": 22841555, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012375", "url": "https://www.ensembl.org/id/ENSBTAG00000012375" } ] } } ], "crossref": [ { "id": "Q2T9Z7", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Z7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767834", "url": "https://www.ncbi.nlm.nih.gov/gene/767834", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767834", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767834", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9Z7", "url": "https://www.orthodb.org/?gene=Q2T9Z7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070424", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Z7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDTDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS", "length": 617, "header": "sp|Q2T9Z7-1|KLHL9_BOVIN Isoform 1 of Kelch-like protein 9 OS=Bos taurus OX=9913 GN=KLHL9 PE=2 SV=1 CANONICAL=Q2T9Z7-1" }, "isoforms": [ { "isoform_ac": "Q2T9Z7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7/entry#Q2T9Z7-1", "sequence": { "sequence": "MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDTDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS", "length": 617, "header": "sp|Q2T9Z7-1|KLHL9_BOVIN Isoform 1 of Kelch-like protein 9 OS=Bos taurus OX=9913 GN=KLHL9 PE=2 SV=1 CANONICAL=Q2T9Z7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767834", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767834", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Z7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 617, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Z7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Z7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z7" }, { "id": "PRU00037", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000255", "start_pos": 50, "end_pos": 119, "start_aa": "Cys", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA05-1", "uniprot_ac": "Q2TA05", "uniprot_id": "SPO16_BOVIN", "mass": { "chemical_mass": 20622.0, "monoisotopic_mass": 20622.0 }, "refseq": { "ac": "NP_001033113", "name": "protein SPO16 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" }, "gene_names": [ { "name": "SPO16", "type": "recommended", "evidence": [ { "id": "Q2TA05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ] }, { "name": "C1orf146", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] }, { "name": "C3H1orf146", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] }, { "name": "SCRE", "type": "synonym", "evidence": [ { "id": "Q2TA05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ] }, { "name": "SPO16", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] } ], "protein_names": [ { "name": "Protein SPO16 homolog", "type": "recommended", "evidence": [ { "id": "Q2TA05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA05/entry#names_and_taxonomy" } ] }, { "name": "Synaptonemal complex reinforcing element", "type": "synonym", "evidence": [ { "id": "Q2TA05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA05/entry#names_and_taxonomy" } ] }, { "name": "protein SPO16 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] }, { "name": "synaptonemal complex reinforcing element", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] }, { "name": "uncharacterized protein C1orf146 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113" } ] } ], "function": [ { "annotation": "Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05#function" }, { "database": "UniProtKB", "id": "Q3KQP7", "url": "https://www.uniprot.org/uniprotkb/Q3KQP7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPO16", "url": "https://www.uniprot.org/uniprotkb/Q2TA05", "locus": {} } ], "crossref": [ { "id": "Q2TA05", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027936", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027936", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504212", "url": "https://www.ncbi.nlm.nih.gov/gene/504212", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504212", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504212", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QNHDTCR", "url": "https://omabrowser.org/oma/group/QNHDTCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA05", "url": "https://www.orthodb.org/?gene=Q2TA05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31408:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31408:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033113", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA05-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAESDGKEKIKWTTTIIISSSLKSYEVAAALENRSHKVRYSDSVENGSIIFSLSGVAFLLMDARECFMSAEETFLAKIEKFINIHQNSFLVLFAALHGPEEWKLMFRIQQRFLGSNLRILPVHNTVNAINLMCTIAKITSKSYIDSICYRMITTKAYIIEQSPVWKTLQKIKLSSDTFNPN", "length": 181, "header": "sp|Q2TA05-1|SPO16_BOVIN Isoform 1 of Protein SPO16 homolog OS=Bos taurus OX=9913 GN=SPO16 PE=2 SV=1 CANONICAL=Q2TA05-1" }, "isoforms": [ { "isoform_ac": "Q2TA05-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA05/entry#Q2TA05-1", "sequence": { "sequence": "MAESDGKEKIKWTTTIIISSSLKSYEVAAALENRSHKVRYSDSVENGSIIFSLSGVAFLLMDARECFMSAEETFLAKIEKFINIHQNSFLVLFAALHGPEEWKLMFRIQQRFLGSNLRILPVHNTVNAINLMCTIAKITSKSYIDSICYRMITTKAYIIEQSPVWKTLQKIKLSSDTFNPN", "length": 181, "header": "sp|Q2TA05-1|SPO16_BOVIN Isoform 1 of Protein SPO16 homolog OS=Bos taurus OX=9913 GN=SPO16 PE=2 SV=1 CANONICAL=Q2TA05-1" }, "locus": { "chromosome": "3", "start_pos": 51177819, "end_pos": 51167307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040290.5", "url": "https://www.ensembl.org/id/ENSBTAT00000040290.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040067.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040067.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504212", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504212", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GE02-1", "protein_name": "Uncharacterized protein C1orf146 homolog", "gene_name": "CUNH1orf146", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDSSGGKERIKWTTTIIISSSLKSYEISTALENRSHKVRYSDTLERGSIVFSLSGVAFLLMDAKECMISAEEIFLTKIEKFINIHQNSFLVLFAPLHGPEEWTLMFRIHQRFLGSNLRILPVHNTVNAVDLMCTIAKTTSKPTIDSICYRMITTKAYIIEQSPVWRTLQKIKLSTDSVSPNLEY", "length": 184 }, "evidence": [ { "id": "Q2TA05", "url": "https://omabrowser.org/oma/group/Q2TA05/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NUG9-1", "protein_name": "C1orf146 homolog", "gene_name": "C1orf146", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTDNSRQEQSKWSTTVIMSTGLQNHEISTILQRQQHRVRYSESVEIGSVIFSLSGVAFLLADIQDLLARGEEQFLERIQKFINIHRNGFLVLSAALHGPQEWNVMFRIQRRILGSNLRIIPVHNTAETVKLMLTIAKMNSKPRADDVSQKMAMTKTHIIENSPVWKMLQEYQQLHSN", "length": 177 }, "evidence": [ { "id": "Q2TA05", "url": "https://omabrowser.org/oma/group/Q2TA05/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3KQP7-1", "protein_name": "Protein SPO16 homolog", "gene_name": "Spo16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMDERRGKERVQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSFLVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQKIKLSSDSVSADSGE", "length": 186 }, "evidence": [ { "id": "Q2TA05", "url": "https://omabrowser.org/oma/group/Q2TA05/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5VVC0-1", "protein_name": "Protein SPO16 homolog", "gene_name": "SPO16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESGKEKIKWTTTIIISSSLKSYEVATALENRSHKVRYSDSVENGSIIFSLSGVAFLLMDTKECLLSTEEIFLAKIEKFINIHQNSFLVLSAALHGPEEWKLMFRIQQRFLGCNLRILPVHNTVNAINLMCTIAKTTSKPYIDSICYRMITAKAYIIEQSPVWKTLQKIKLNSDSVNPN", "length": 180 }, "evidence": [ { "id": "Q2TA05", "url": "https://omabrowser.org/oma/group/Q2TA05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "synaptonemal complex assembly", "id": "GO:0007130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "database": "UniProtKB", "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ], "pmid": "" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q2TA05", "url": "https://www.uniprot.org/uniprotkb/Q2TA05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 181, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA35-1", "uniprot_ac": "Q2TA35", "uniprot_id": "TM2D2_BOVIN", "mass": { "chemical_mass": 23241.0, "monoisotopic_mass": 23241.0 }, "refseq": { "ac": "NP_001033145", "name": "TM2 domain-containing protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033145" }, "gene_names": [ { "name": "TM2D2", "type": "recommended", "evidence": [ { "id": "Q2TA35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA35" } ] }, { "name": "TM2D2", "type": "synonym", "evidence": [ { "id": "NP_001033145", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033145" } ] } ], "protein_names": [ { "name": "TM2 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q2TA35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA35/entry#names_and_taxonomy" } ] }, { "name": "TM2 domain-containing protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033145", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033145" } ] }, { "name": "TM2 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001033145", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033145" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA35", "url": "https://www.uniprot.org/uniprotkb/Q2TA35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM2D2", "url": "https://www.uniprot.org/uniprotkb/Q2TA35", "locus": { "chromosome": "27", "start_pos": 34146047, "end_pos": 34152126, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003516", "url": "https://www.ensembl.org/id/ENSBTAG00000003516" } ] } } ], "crossref": [ { "id": "Q2TA35", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003516", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003516", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507906", "url": "https://www.ncbi.nlm.nih.gov/gene/507906", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507906", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507906", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIDHKGN", "url": "https://omabrowser.org/oma/group/PIDHKGN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA35", "url": "https://www.orthodb.org/?gene=Q2TA35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21016:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21016:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033145", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA35", "url": "https://www.uniprot.org/uniprotkb/Q2TA35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA35-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLGGYPVSYLLLCGQAALLLGNLLLLHCVSRSHSHNATAEPELTSAGAAHPEGSPGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNTTAFQELGYGCLKFGGQAYRDVEHTRVQCRALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTIY", "length": 214, "header": "sp|Q2TA35-1|TM2D2_BOVIN Isoform 1 of TM2 domain-containing protein 2 OS=Bos taurus OX=9913 GN=TM2D2 PE=2 SV=1 CANONICAL=Q2TA35-1" }, "isoforms": [ { "isoform_ac": "Q2TA35-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA35/entry#Q2TA35-1", "sequence": { "sequence": "MVLGGYPVSYLLLCGQAALLLGNLLLLHCVSRSHSHNATAEPELTSAGAAHPEGSPGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNTTAFQELGYGCLKFGGQAYRDVEHTRVQCRALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTIY", "length": 214, "header": "sp|Q2TA35-1|TM2D2_BOVIN Isoform 1 of TM2 domain-containing protein 2 OS=Bos taurus OX=9913 GN=TM2D2 PE=2 SV=1 CANONICAL=Q2TA35-1" }, "locus": { "chromosome": "27", "start_pos": 34151903, "end_pos": 34146305, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004567.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004567.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004567.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004567.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 37, "start_aa": "Asn", "end_pos": 37, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn37", "evidence": [ { "id": "Q2TA35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA35#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn92", "evidence": [ { "id": "Q2TA35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA35#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507906", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507906", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P3V1-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "TM2D2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPRRGGSLGYALLCGQAVLLLGNLLLLHGASRGLPHNGSEPEAPGSEPAAATWAYSDPRAPLVLCTYLPEEFVECDEPVDHGGNATAQQELGHGCVKFGGQAHGDVDHTRVQCRALDGIECAEPRSFLRGSRPCVRYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 207 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H1K7-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "Tm2d2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSFNATAELDLTPSGAAHPEGPVAPSWEYSDPHSPVILCSYLPDEFVDCDAPVDHVGNATASQELGYGCLKFGGQAYSDVEHTAVQCRALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 213 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LTJ8-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "TM2D2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSHNTTAEPEFTTAGAAQLEGSTGALSWEYGDPQSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCRALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 214 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q566R2-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "Tm2d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSFNATAELDLTPSGAAHLEGPAASSWEYSDPNSPVILCSYLPDEFVDCDAPVDHVGNATAYQELGYGCLKFGGQAYSDVEHTAVQCRALEGIECASPRTFLRKNKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 213 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DHN3-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "tm2d2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQISVNYILLCGQFLLFFTVLLLQCLEGIHSQNSTEPPGNRVTTSKPVLFSEQPEENVTESGSVIPTETSNHTEQYEYNPPSPVVLCRYLPEEFIFCQDPVDHGGNVSAFQELGYGCVKFGGQVYKDVNHTQVLCTALDGIECAGPREFLRGNEPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLTPSDSSNWCTFY", "length": 229 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8R0I4-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "Tm2d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSFNATAELDLTPSGAAHLEGPAASSWEYSDPNSPVILCSYLPDEFVDCDAPVDHVGNATASQELGYGCLKFGGQAYSDVQHTAVQCRALEGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 213 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BX73-1", "protein_name": "TM2 domain-containing protein 2", "gene_name": "TM2D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY", "length": 214 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VY86-1", "protein_name": "TM2 domain-containing protein amaretto", "gene_name": "amrt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRIFYGLLAFLVARQHDAQAIQARSDKEQPQTVVSGTAVQSVVPVQAQLGSGMGPSSSSSSASSASGGAGNSAFYPLGPNVMCSFLPRDFLDCKDPVDHRENATAQQEKKYGCLKFGGSTYEEVEHAMVWCTVFADIECYGNRTFLRAGVPCVRYTDHYFVTTLIYSMLLGFLGMDRFCLGQTGTAVGKLLTMGGVGVWWIIDVILLITNNLLPEDGSNWNPYV", "length": 224 }, "evidence": [ { "id": "Q2TA35", "url": "https://omabrowser.org/oma/group/Q2TA35/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TA35", "url": "https://www.uniprot.org/uniprotkb/Q2TA35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA35-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 214, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA35-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA35" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TA35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA35" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TM2", "eco_id": "ECO_0000255", "start_pos": 147, "end_pos": 195, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 37, 92 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 37, "end_pos": 39 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA42-1", "uniprot_ac": "Q2TA42", "uniprot_id": "ARGL1_BOVIN", "mass": { "chemical_mass": 33216.0, "monoisotopic_mass": 33216.0 }, "refseq": { "ac": "NP_001033279", "name": "arginine and glutamate-rich protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033279" }, "gene_names": [ { "name": "ARGLU1", "type": "recommended", "evidence": [ { "id": "Q2TA42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ] }, { "name": "ARGLU1", "type": "synonym", "evidence": [ { "id": "NP_001033279", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033279" } ] } ], "protein_names": [ { "name": "Arginine and glutamate-rich protein 1", "type": "recommended", "evidence": [ { "id": "Q2TA42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA42/entry#names_and_taxonomy" } ] }, { "name": "arginine and glutamate-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033279", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033279" } ] } ], "function": [ { "annotation": "Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1. Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (By similarity). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (By similarity). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (By similarity). May also indirectly modulate alternative splicing (By similarity). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization. Regulates splicing of genes involved in neurogenesis and chromatin organization. Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42#function" }, { "database": "UniProtKB", "id": "Q9NWB6", "url": "https://www.uniprot.org/uniprotkb/Q9NWB6#function" }, { "database": "UniProtKB", "id": "Q3UL36", "url": "https://www.uniprot.org/uniprotkb/Q3UL36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARGLU1", "url": "https://www.uniprot.org/uniprotkb/Q2TA42", "locus": { "chromosome": "12", "start_pos": 82297128, "end_pos": 82322844, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015124", "url": "https://www.ensembl.org/id/ENSBTAG00000015124" } ] } } ], "crossref": [ { "id": "Q2TA42", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA42", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015124", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540543", "url": "https://www.ncbi.nlm.nih.gov/gene/540543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540543", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540543", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VNSHGRH", "url": "https://omabrowser.org/oma/group/VNSHGRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31711:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31711:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15346", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15346", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033279", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA42-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 273, "header": "sp|Q2TA42-1|ARGL1_BOVIN Isoform 1 of Arginine and glutamate-rich protein 1 OS=Bos taurus OX=9913 GN=ARGLU1 PE=2 SV=1 CANONICAL=Q2TA42-1" }, "isoforms": [ { "isoform_ac": "Q2TA42-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA42/entry#Q2TA42-1", "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 273, "header": "sp|Q2TA42-1|ARGL1_BOVIN Isoform 1 of Arginine and glutamate-rich protein 1 OS=Bos taurus OX=9913 GN=ARGLU1 PE=2 SV=1 CANONICAL=Q2TA42-1" }, "locus": { "chromosome": "12", "start_pos": 82322611, "end_pos": 82297181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020126.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020126.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020126.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020126.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Ser266" }, { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Ser58" }, { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Ser60" }, { "start_pos": 61, "end_pos": 61, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Thr61" }, { "start_pos": 76, "end_pos": 76, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Ser76" }, { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "site_lbl": "Ser77" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540543", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540543", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RFB3-1", "protein_name": "Arginine and glutamate rich 1", "gene_name": "ARGLU1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "PGTCGARNQRLVTASSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 279 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UL36-1", "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "Arglu1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 271 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BJT0-1", "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "Arglu1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 271 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZL35-1", "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "ARGLU1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKNRSRSRSRSREKERARKRSKSRESKRNRRRESRSRSRSNTAPSSRRDRERERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLKIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKSQD", "length": 276 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7ZVW9-1", "protein_name": "Arginine and glutamate-rich protein 1-B", "gene_name": "arglu1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGRSRSRSSSRSKHSKTSKHSKKRSRSRSRSRDRERKRRSKSRESKRNRRRESRSRSRSNTATSRRDRERAASPPERIDIFGRALSKRSAVDEKQKKEEEEKKVEMERQRRIRQQEIEERLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILVDNNRKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQKQQKEEQKMILGKGKSRPKLSFSLKASE", "length": 269 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9LYU2-1", "protein_name": "Arginine/glutamate-rich 1 protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARNDSRSRSPSHRRRYSRSPVTHRSSRRTRRDRSRSPYTSRHKKSRSPAPRQHQRDRSSSLSPSEHRIAIEVKKEQEDKARLQHEAELKRLEEETAQRIEEAVRKNVEERMKTEEVKEEIERRTKEAYEKMFLDVEIQLKKEKEAALNEARRKEEQARREREELDKMLEENSRRVEESQRREAMELQRKEEERYRELELLQRQKEEAARRKKLEEEEEIRNSSKLSNGNRSRSKLHFGMGL", "length": 242 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NWB6-1", "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "ARGLU1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD", "length": 273 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VL63-1", "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "Arglu1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGSRSRTPSPSGKRRHHKSKHKKRSKSHHDHERPSTRTDRDKSSEVNNHGRHRERDRDRERDRHRSDRHTERDYRHSPSILKSRKRSSSSSSDSQYSEQESQRSKQKRSRFKKLDEQNQMQVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMEREMMLELERRREQIREEERRREEDEKQKREELEEILAENNRKIEEAQRKLAEERLAIIEEQRLMDEERQRMRKEQEKRVKEEQKVILGKNNSRPKLSFSLKPGAL", "length": 290 }, "evidence": [ { "id": "Q2TA42", "url": "https://omabrowser.org/oma/group/Q2TA42/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pre-mRNA binding", "id": "GO:0036002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036002", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q2TA42", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA42-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 273, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA42-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA42" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TA42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "LXXLL motif 1; degenerate", "eco_id": "ECO_0000250", "start_pos": 172, "end_pos": 176, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TA42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA42" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "LXXLL motif 2; degenerate", "eco_id": "ECO_0000250", "start_pos": 201, "end_pos": 205, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 58, 60, 61, 76, 77, 266 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA46-1", "uniprot_ac": "Q2TA46", "uniprot_id": "UBL3_BOVIN", "mass": { "chemical_mass": 13157.0, "monoisotopic_mass": 13157.0 }, "refseq": { "ac": "NP_001033233", "name": "ubiquitin-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233" }, "gene_names": [ { "name": "UBL3", "type": "recommended", "evidence": [ { "id": "Q2TA46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA46" } ] }, { "name": "UBL3", "type": "synonym", "evidence": [ { "id": "NP_001033233", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein 3", "type": "recommended", "evidence": [ { "id": "Q2TA46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA46/entry#names_and_taxonomy" } ] }, { "name": "MUB", "type": "synonym", "evidence": [ { "id": "NP_001033233", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233" }, { "id": "Q2TA46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA46/entry#names_and_taxonomy" } ] }, { "name": "Membrane-anchored ubiquitin-fold protein", "type": "synonym", "evidence": [ { "id": "Q2TA46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA46/entry#names_and_taxonomy" } ] }, { "name": "membrane-anchored ubiquitin-fold protein", "type": "synonym", "evidence": [ { "id": "NP_001033233", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233" } ] }, { "name": "ubiquitin-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001033233", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA46", "url": "https://www.uniprot.org/uniprotkb/Q2TA46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBL3", "url": "https://www.uniprot.org/uniprotkb/Q2TA46", "locus": { "chromosome": "12", "start_pos": 30854060, "end_pos": 30806229, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012170", "url": "https://www.ensembl.org/id/ENSBTAG00000012170" } ] } } ], "crossref": [ { "id": "Q2TA46", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012170", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012170", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526950", "url": "https://www.ncbi.nlm.nih.gov/gene/526950", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526950", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526950", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPDEWYE", "url": "https://omabrowser.org/oma/group/WPDEWYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA46", "url": "https://www.orthodb.org/?gene=Q2TA46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13169:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13169:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13881", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13881", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033233", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA46", "url": "https://www.uniprot.org/uniprotkb/Q2TA46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA46-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117, "header": "sp|Q2TA46-1|UBL3_BOVIN Isoform 1 of Ubiquitin-like protein 3 OS=Bos taurus OX=9913 GN=UBL3 PE=3 SV=1 CANONICAL=Q2TA46-1" }, "isoforms": [ { "isoform_ac": "Q2TA46-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA46/entry#Q2TA46-1", "sequence": { "sequence": "MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117, "header": "sp|Q2TA46-1|UBL3_BOVIN Isoform 1 of Ubiquitin-like protein 3 OS=Bos taurus OX=9913 GN=UBL3 PE=3 SV=1 CANONICAL=Q2TA46-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526950", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526950", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B7A4-1", "protein_name": "Ubiquitin-like protein", "gene_name": "UBL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117 }, "evidence": [ { "id": "Q2TA46", "url": "https://omabrowser.org/oma/group/Q2TA46/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GWG6-1", "protein_name": "Ubiquitin-like protein", "gene_name": "Ubl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSHVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117 }, "evidence": [ { "id": "Q2TA46", "url": "https://omabrowser.org/oma/group/Q2TA46/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95164-1", "protein_name": "Ubiquitin-like protein 3", "gene_name": "UBL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117 }, "evidence": [ { "id": "Q2TA46", "url": "https://omabrowser.org/oma/group/Q2TA46/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2M6-1", "protein_name": "Ubiquitin-like protein 3", "gene_name": "Ubl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSHVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL", "length": 117 }, "evidence": [ { "id": "Q2TA46", "url": "https://omabrowser.org/oma/group/Q2TA46/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2TA46", "url": "https://www.uniprot.org/uniprotkb/Q2TA46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA46-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 117, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA46-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA46" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TA46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA46" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 88, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBG7-1", "uniprot_ac": "Q2TBG7", "uniprot_id": "ISCA2_BOVIN", "mass": { "chemical_mass": 16436.0, "monoisotopic_mass": 16436.0 }, "refseq": { "ac": "NP_001033772", "name": "iron-sulfur cluster assembly 2 homolog, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" }, "gene_names": [ { "name": "ISCA2", "type": "recommended", "evidence": [ { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ] }, { "name": "HBLD1", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" }, { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ] }, { "name": "ISCA2", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" } ] } ], "protein_names": [ { "name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7/entry#names_and_taxonomy" } ] }, { "name": "HESB like domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" } ] }, { "name": "HESB-like domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" }, { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7/entry#names_and_taxonomy" } ] }, { "name": "iron-sulfur cluster assembly 2 homolog, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" } ] }, { "name": "iron-sulfur cluster assembly 2 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772" } ] } ], "function": [ { "annotation": "Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7#function" }, { "database": "UniProtKB", "id": "Q86U28", "url": "https://www.uniprot.org/uniprotkb/Q86U28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISCA2", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7", "locus": { "chromosome": "10", "start_pos": 85786093, "end_pos": 85783280, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021956", "url": "https://www.ensembl.org/id/ENSBTAG00000021956" } ] } } ], "crossref": [ { "id": "Q2TBG7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021956", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613290", "url": "https://www.ncbi.nlm.nih.gov/gene/613290", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613290", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613290", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SFQIHNP", "url": "https://omabrowser.org/oma/group/SFQIHNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBG7", "url": "https://www.orthodb.org/?gene=Q2TBG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43011:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43011:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1362409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9854311", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVRGLTAVALRVVTPWQRSRLLAASRGPRALREVSFSSPEAGEGQIHLTDSCVQRLLEITEGSEFLRLEVEGGGCSGFQYKFSLDTVINPDDRVFEKGGARVVVDSDSLAFVKGAHVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSVKL", "length": 152, "header": "sp|Q2TBG7-1|ISCA2_BOVIN Isoform 1 of Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Bos taurus OX=9913 GN=ISCA2 PE=2 SV=1 CANONICAL=Q2TBG7-1" }, "isoforms": [ { "isoform_ac": "Q2TBG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7/entry#Q2TBG7-1", "sequence": { "sequence": "MAAVRGLTAVALRVVTPWQRSRLLAASRGPRALREVSFSSPEAGEGQIHLTDSCVQRLLEITEGSEFLRLEVEGGGCSGFQYKFSLDTVINPDDRVFEKGGARVVVDSDSLAFVKGAHVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSVKL", "length": 152, "header": "sp|Q2TBG7-1|ISCA2_BOVIN Isoform 1 of Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Bos taurus OX=9913 GN=ISCA2 PE=2 SV=1 CANONICAL=Q2TBG7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613290", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613290", "resource": "KEGG Pathway" }, { "id": "R-BTA-1362409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "resource": "Reactome", "description": "Mitochondrial iron-sulfur cluster biogenesis" }, { "id": "R-BTA-9854311", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "resource": "Reactome", "description": "Maturation of TCA enzymes and regulation of TCA cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZSL2-1", "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "Isca2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAARALSLTVEAFGAPIPRRQGRLLAAFPRLLTRWETTSSIPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDNLAYVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKI", "length": 154 }, "evidence": [ { "id": "Q2TBG7", "url": "https://omabrowser.org/oma/group/Q2TBG7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I937-1", "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "Isca2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAATRPLSLTAAAFRAVIPWPRGRLLAPSPGLLTRWEATSSNPEAGEGQIRLTESCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKIRHNDR", "length": 159 }, "evidence": [ { "id": "Q2TBG7", "url": "https://omabrowser.org/oma/group/Q2TBG7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q86U28-1", "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "ISCA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAWGSSLTAATQRAVTPWPRGRLLTASLGPQARREASSSSPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKL", "length": 154 }, "evidence": [ { "id": "Q2TBG7", "url": "https://omabrowser.org/oma/group/Q2TBG7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCB8-1", "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "Isca2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASRALSLTAEAVRAVIPRRSGRLLAVFPRLLTRWETTSSIPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSVKV", "length": 154 }, "evidence": [ { "id": "Q2TBG7", "url": "https://omabrowser.org/oma/group/Q2TBG7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VC65-1", "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "Dmel\\CG13623", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAFLLRQVARSGLQRNLILMRHATASTSANPELSVQVSESCLKRLREICVDGSFLRVTVEGGGCSGFQYKFDLDKQLNEDDRQFGEAEAKVVIDTVSLEYCSGATVDYHSELIRAGFRMVANPLAEQGCSCGSSFSIKL", "length": 139 }, "evidence": [ { "id": "Q2TBG7", "url": "https://omabrowser.org/oma/group/Q2TBG7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" }, { "name": "mitochondrial [4Fe-4S] assembly complex", "id": "GO:0120510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120510", "evidence": [ { "database": "UniProtKB", "id": "Q2TBG7", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBG7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7#function" }, { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "binding_site_uniprot": 142, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 142, "end_pos": 142, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7#function" }, { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "binding_site_uniprot": 144, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 144, "end_pos": 144, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7#function" }, { "id": "Q2TBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBG7" } ], "binding_site_uniprot": 77, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 77, "end_pos": 77, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBH0-1", "uniprot_ac": "Q2TBH0", "uniprot_id": "CMA1A_BOVIN", "mass": { "chemical_mass": 27634.0, "monoisotopic_mass": 27634.0 }, "refseq": { "ac": "NP_001073721", "name": "ciliary microtubule associated protein 1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" }, "gene_names": [ { "name": "CIMAP1A", "type": "recommended", "evidence": [ { "id": "Q2TBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ] }, { "name": "CIMAP1A", "type": "synonym", "evidence": [ { "id": "NP_001073721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" } ] }, { "name": "ODF3", "type": "synonym", "evidence": [ { "id": "NP_001073721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" }, { "id": "Q2TBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ] } ], "protein_names": [ { "name": "Ciliary microtubule associated protein 1A", "type": "recommended", "evidence": [ { "id": "Q2TBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0/entry#names_and_taxonomy" } ] }, { "name": "Outer dense fiber of sperm tails protein 3", "type": "synonym", "evidence": [ { "id": "Q2TBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0/entry#names_and_taxonomy" } ] }, { "name": "Outer dense fiber protein 3", "type": "synonym", "evidence": [ { "id": "Q2TBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0/entry#names_and_taxonomy" } ] }, { "name": "ciliary microtubule associated protein 1A", "type": "synonym", "evidence": [ { "id": "NP_001073721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" } ] }, { "name": "outer dense fiber of sperm tails protein 3", "type": "synonym", "evidence": [ { "id": "NP_001073721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" } ] }, { "name": "outer dense fiber protein 3", "type": "synonym", "evidence": [ { "id": "NP_001073721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721" } ] } ], "function": [ { "annotation": "Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0#function" }, { "database": "UniProtKB", "id": "Q920N1", "url": "https://www.uniprot.org/uniprotkb/Q920N1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIMAP1A", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0", "locus": {} } ], "crossref": [ { "id": "Q2TBH0", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "509757", "url": "https://www.ncbi.nlm.nih.gov/gene/509757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR010736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBH0", "url": "https://www.orthodb.org/?gene=Q2TBH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21580", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21580", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21580:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21580:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073721", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEVWVGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFVKQTPTKLRAPAYSFRGAPMLLAENCSPGPRYSVNPKILRTGKDLGPAYSILGRYHTKTTLTPGPGDYFPEKSTKHVFDSAPSHSISARTKTFRVDSTPGPAAYMLPMVMGPHTIGKVSQPSFSIKGRSKLGSFSDDLHKTPGPAAYRQTDVQVTKFKAPQYTMAARVEPPGDKTLKPGPGAHSPEKVTMTRPCAPVVSFGIKHSDYMTPLVVDVD", "length": 254, "header": "sp|Q2TBH0-1|CMA1A_BOVIN Isoform 1 of Ciliary microtubule associated protein 1A OS=Bos taurus OX=9913 GN=CIMAP1A PE=1 SV=1 CANONICAL=Q2TBH0-1" }, "isoforms": [ { "isoform_ac": "Q2TBH0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0/entry#Q2TBH0-1", "sequence": { "sequence": "MAEEVWVGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFVKQTPTKLRAPAYSFRGAPMLLAENCSPGPRYSVNPKILRTGKDLGPAYSILGRYHTKTTLTPGPGDYFPEKSTKHVFDSAPSHSISARTKTFRVDSTPGPAAYMLPMVMGPHTIGKVSQPSFSIKGRSKLGSFSDDLHKTPGPAAYRQTDVQVTKFKAPQYTMAARVEPPGDKTLKPGPGAHSPEKVTMTRPCAPVVSFGIKHSDYMTPLVVDVD", "length": 254, "header": "sp|Q2TBH0-1|CMA1A_BOVIN Isoform 1 of Ciliary microtubule associated protein 1A OS=Bos taurus OX=9913 GN=CIMAP1A PE=1 SV=1 CANONICAL=Q2TBH0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509757", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "outer dense fiber", "id": "GO:0001520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001520", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH0", "url": "https://www.uniprot.org/uniprotkb/Q2TBH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBH0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBH0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBH0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBH1-1", "uniprot_ac": "Q2TBH1", "uniprot_id": "CENPM_BOVIN", "mass": { "chemical_mass": 19635.0, "monoisotopic_mass": 19635.0 }, "refseq": { "ac": "NP_001033775", "name": "centromere protein M", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033775" }, "gene_names": [ { "name": "CENPM", "type": "recommended", "evidence": [ { "id": "Q2TBH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ] }, { "name": "CENPM", "type": "synonym", "evidence": [ { "id": "NP_001033775", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033775" } ] } ], "protein_names": [ { "name": "Centromere protein M", "type": "recommended", "evidence": [ { "id": "Q2TBH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#names_and_taxonomy" } ] }, { "name": "CENP-M", "type": "synonym", "evidence": [ { "id": "NP_001033775", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033775" }, { "id": "Q2TBH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#names_and_taxonomy" } ] }, { "name": "centromere protein M", "type": "synonym", "evidence": [ { "id": "NP_001033775", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033775" } ] } ], "function": [ { "annotation": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1#function" }, { "database": "UniProtKB", "id": "A0AAF6YUJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUJ3#function" }, { "database": "UniProtKB", "id": "ARBA00053608", "url": "https://www.uniprot.org/uniprotkb/ARBA00053608#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPM", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1", "locus": { "chromosome": "5", "start_pos": 112916337, "end_pos": 112928665, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009956", "url": "https://www.ensembl.org/id/ENSBTAG00000009956" } ] } } ], "crossref": [ { "id": "Q2TBH1", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009956", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615953", "url": "https://www.ncbi.nlm.nih.gov/gene/615953", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615953", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615953", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTLPLDI", "url": "https://omabrowser.org/oma/group/CTLPLDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MS72", "url": "https://www.orthodb.org/?gene=A0A3Q1MS72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBH1", "url": "https://www.orthodb.org/?gene=Q2TBH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34436", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34436", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34436:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34436:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11111", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11111", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033775", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S432", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S432", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S432-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S432-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSALRPLDKLPGLNTATILLVGTEDALLQQLADSMLKADCTSELKVHLARSLPLPCSVNRPRIDLIVFVVNLHSKLSLQSVEESLCHLDAAFFLGKVAFLATGAGRDSHCSIHRNTVVKLAHTYRSPLLFCDLEIEDFRAAMAQRLVRLLQICAGHVPGVSALNLLSLMRGSENPSLEDL", "length": 180, "header": "sp|Q2TBH1-1|CENPM_BOVIN Isoform 1 of Centromere protein M OS=Bos taurus OX=9913 GN=CENPM PE=2 SV=1 CANONICAL=Q2TBH1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MS72-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#A0A3Q1MS72-1", "sequence": { "sequence": "MSALRPLDKLPGLNTATILLVGTEDALLQQLADSMLKADCTSELKVHLARSLPLPCSVNRPRIDLIVFVVNLHSKLSLQSVEESLCHLDAAFFLGKVAFLATGAGRDSHCSIHRNTVVKLAHTYRSPLLFCDLEPVQCCSRLSGGSIEQSSVNTPNPVLVEETR", "length": 164, "header": "tr|A0A3Q1MS72-1|A0A3Q1MS72_BOVIN Computationally mapped isoform of Centromere protein M OS=Bos taurus OX=9913 GN=CENPM PE=4 SV=2 CANONICAL=Q2TBH1-1" }, "locus": { "chromosome": "5", "start_pos": 112928654, "end_pos": 112917341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084158.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084158.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072800.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072800.2" } ] } }, { "isoform_ac": "A0AAA9S432-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#A0AAA9S432-1", "sequence": { "sequence": "MSALRPLDKLPGLNTATILLVGTEDALLQQLADSMLKADCTSELKVHLARSLPLPCSVNRPRIDLIVFVVNLHSKLSLQSVEESLCHLDAAFFLGKVAFLATGDRRLP", "length": 108, "header": "tr|A0AAA9S432-1|A0AAA9S432_BOVIN Computationally mapped isoform of Centromere protein M OS=Bos taurus OX=9913 GN=CENPM PE=4 SV=1 CANONICAL=Q2TBH1-1" }, "locus": { "chromosome": "5", "start_pos": 112928654, "end_pos": 112917328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122851.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122851.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080696.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080696.1" } ] } }, { "isoform_ac": "A0AAF6YUJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#A0AAF6YUJ3-1", "sequence": { "sequence": "MPAVVPSLVGTEDALLQQLADSMLKADCTSELKVHLARSLPLPCSVNRPRIDLIVFVVNLHSKLSLQSVEESLCHLDAAFFLGKVAFLATGAGRDSHCSIHRNTVVKLAHTYRSPLLFCDLEIEDFRAAMAQRLVRLLQICAGHVPGVSALNLLSLMRGSENPSLEDL", "length": 168, "header": "tr|A0AAF6YUJ3-1|A0AAF6YUJ3_BOVIN Computationally mapped isoform of Centromere protein M OS=Bos taurus OX=9913 GN=CENPM PE=4 SV=1 CANONICAL=Q2TBH1-1" }, "locus": { "chromosome": "5", "start_pos": 112928194, "end_pos": 112917204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013133.4", "url": "https://www.ensembl.org/id/ENSBTAT00000013133.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013133.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013133.3" } ] } }, { "isoform_ac": "Q2TBH1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1/entry#Q2TBH1-1", "sequence": { "sequence": "MSALRPLDKLPGLNTATILLVGTEDALLQQLADSMLKADCTSELKVHLARSLPLPCSVNRPRIDLIVFVVNLHSKLSLQSVEESLCHLDAAFFLGKVAFLATGAGRDSHCSIHRNTVVKLAHTYRSPLLFCDLEIEDFRAAMAQRLVRLLQICAGHVPGVSALNLLSLMRGSENPSLEDL", "length": 180, "header": "sp|Q2TBH1-1|CENPM_BOVIN Isoform 1 of Centromere protein M OS=Bos taurus OX=9913 GN=CENPM PE=2 SV=1 CANONICAL=Q2TBH1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615953", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615953", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-606279", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0L681-1", "protein_name": "Centromere protein M", "gene_name": "Cenpm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VGVPVRTWLSRVSRRRPADPSELVSTEDALLQQLAESVLKIDCATELRVHLANSLPLPSNANRPRIDLIVFVINLHSKYSLQKVEESLNHVDSSFFLGKVCFLVTGAGRESHCSVHQNTVMKLAHTYRSPLLFCDLQVESFRAAMAQRLVRVLQVCAGHVPGISALNLLSLLRSPENPPSKEL", "length": 183 }, "evidence": [ { "id": "Q2TBH1", "url": "https://omabrowser.org/oma/group/Q2TBH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IBR2-1", "protein_name": "Centromere protein M", "gene_name": "Cenpm", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSVLRSMDKLPDLNRATILLVGTEDALLQKLAESMLQEHCASELRVHLANSLPLPSTVNRPRIDLIVFVINLHSKYSLRKVEECLSHVDSSFFLGKVCFLATGAGRESHCSIHQNTVIKLARTYRSPLLFCDLEVGSFRATMAQRLVRMLQICAGHVPGISAVNLLSLLRCSDSTPSKEL", "length": 180 }, "evidence": [ { "id": "Q2TBH1", "url": "https://omabrowser.org/oma/group/Q2TBH1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1T7B9-1", "protein_name": "Centromere protein M", "gene_name": "CENPM", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVLRPFDKLPELNSATILLVGAEGGPQQQLAEAMLREKKDFNINIHLASSLPLPSERDHLRPRIDLIAFVIDIKSKYSLKNVQASLAYVDVRFFLGKVCFLVTGVGRANNCSVEMNAIWKLGEDYCSPVIFCELELEGIRVATAQRLLRMLQICAGRVPGVSALYFSLLMRNSAGD", "length": 177 }, "evidence": [ { "id": "Q2TBH1", "url": "https://omabrowser.org/oma/group/Q2TBH1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9CQA0-1", "protein_name": "Centromere protein M", "gene_name": "Cenpm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASELRVHLANSLPLPSNVNRPRIDLIVFVINLHSKYSLQKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVPGVSALNLMSLLRSPENPPSKEL", "length": 180 }, "evidence": [ { "id": "Q2TBH1", "url": "https://omabrowser.org/oma/group/Q2TBH1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NSP4-1", "protein_name": "Centromere protein M", "gene_name": "CENPM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL", "length": 180 }, "evidence": [ { "id": "Q2TBH1", "url": "https://omabrowser.org/oma/group/Q2TBH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBH1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 180, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBH1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBH1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBH9-1", "uniprot_ac": "Q2TBH9", "uniprot_id": "COG8_BOVIN", "mass": { "chemical_mass": 69782.0, "monoisotopic_mass": 69782.0 }, "refseq": { "ac": "NP_001070535", "name": "conserved oligomeric Golgi complex subunit 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070535" }, "gene_names": [ { "name": "COG8", "type": "recommended", "evidence": [ { "id": "Q2TBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ] }, { "name": "COG8", "type": "synonym", "evidence": [ { "id": "NP_001070535", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070535" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 8", "type": "recommended", "evidence": [ { "id": "Q2TBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9/entry#names_and_taxonomy" } ] }, { "name": "COG complex subunit 8", "type": "synonym", "evidence": [ { "id": "NP_001070535", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070535" }, { "id": "Q2TBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 8", "type": "synonym", "evidence": [ { "id": "Q2TBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9/entry#names_and_taxonomy" } ] }, { "name": "conserved oligomeric Golgi complex subunit 8", "type": "synonym", "evidence": [ { "id": "NP_001070535", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070535" } ] } ], "function": [ { "annotation": "Required for normal Golgi function.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG8", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9", "locus": { "chromosome": "18", "start_pos": 36474044, "end_pos": 36480940, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001665", "url": "https://www.ensembl.org/id/ENSBTAG00000001665" } ] } } ], "crossref": [ { "id": "Q2TBH9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "768007", "url": "https://www.ncbi.nlm.nih.gov/gene/768007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBH9", "url": "https://www.orthodb.org/?gene=Q2TBH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21311:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21311:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04124", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04124", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070535", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATATIPSSTTASATTTATAAALGEVEDEGLLASLFRDRFPEAQWRERPDVGRYLRELSGSGLERLRREPERLAEERAQLLQQTRDLAFANYKTFIRGAECTERIHRLFGDVEESLGRLLDRLPSLQQSCRNFVKEAEEISSNRRMNTLTLNRHTEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQQLRTNIQLPACLRVIGFLRQMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEHMVNESAIFHGWVLQKVSQFLQVLETDLNRGIGSRLDSLLGQCMYFGLSFSRVGADFRGQLVPVFQQVAISTFQKAIQEAVEKFQDEMNSYTLISTPAVLGSSALPAAAPVTQPGTLQPPMVLLDFPPLACFLNSILVAFNDLRLCCPVALAQEVTRALEDALDKVTKVILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGIPPTQLSKYGNLGHVNVSVVQEPLAFILPKREPVFCLDKELVPELPAPAPALPPNAPSPEPVTPVTPAVPDAGQEEVESAGPPQPDEPSAGI", "length": 626, "header": "sp|Q2TBH9-1|COG8_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 8 OS=Bos taurus OX=9913 GN=COG8 PE=2 SV=1 CANONICAL=Q2TBH9-1" }, "isoforms": [ { "isoform_ac": "Q2TBH9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9/entry#Q2TBH9-1", "sequence": { "sequence": "MAATATIPSSTTASATTTATAAALGEVEDEGLLASLFRDRFPEAQWRERPDVGRYLRELSGSGLERLRREPERLAEERAQLLQQTRDLAFANYKTFIRGAECTERIHRLFGDVEESLGRLLDRLPSLQQSCRNFVKEAEEISSNRRMNTLTLNRHTEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQQLRTNIQLPACLRVIGFLRQMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEHMVNESAIFHGWVLQKVSQFLQVLETDLNRGIGSRLDSLLGQCMYFGLSFSRVGADFRGQLVPVFQQVAISTFQKAIQEAVEKFQDEMNSYTLISTPAVLGSSALPAAAPVTQPGTLQPPMVLLDFPPLACFLNSILVAFNDLRLCCPVALAQEVTRALEDALDKVTKVILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGIPPTQLSKYGNLGHVNVSVVQEPLAFILPKREPVFCLDKELVPELPAPAPALPPNAPSPEPVTPVTPAVPDAGQEEVESAGPPQPDEPSAGI", "length": 626, "header": "sp|Q2TBH9-1|COG8_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 8 OS=Bos taurus OX=9913 GN=COG8 PE=2 SV=1 CANONICAL=Q2TBH9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 597, "start_aa": "Thr", "end_pos": 597, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr597", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 600, "start_aa": "Thr", "end_pos": 600, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr600", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:768007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768007", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH9", "url": "https://www.uniprot.org/uniprotkb/Q2TBH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 626, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 597, 600 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 316, "end_pos": 318 }, { "start_pos": 550, "end_pos": 552 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBI7-1", "uniprot_ac": "Q2TBI7", "uniprot_id": "IQCC_BOVIN", "mass": { "chemical_mass": 52759.0, "monoisotopic_mass": 52759.0 }, "refseq": { "ac": "NP_001019663", "name": "IQ domain-containing protein C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019663" }, "gene_names": [ { "name": "IQCC", "type": "recommended", "evidence": [ { "id": "Q2TBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7" } ] }, { "name": "IQCC", "type": "synonym", "evidence": [ { "id": "NP_001019663", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019663" } ] } ], "protein_names": [ { "name": "IQ domain-containing protein C", "type": "recommended", "evidence": [ { "id": "Q2TBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7/entry#names_and_taxonomy" } ] }, { "name": "IQ domain-containing protein C", "type": "synonym", "evidence": [ { "id": "NP_001019663", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019663" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBI7", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCC", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7", "locus": { "chromosome": "2", "start_pos": 121316668, "end_pos": 121319689, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015103", "url": "https://www.ensembl.org/id/ENSBTAG00000015103" } ] } } ], "crossref": [ { "id": "Q2TBI7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "507606", "url": "https://www.ncbi.nlm.nih.gov/gene/507606", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR042506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507606", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507606", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBI7", "url": "https://www.orthodb.org/?gene=Q2TBI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16049:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16049:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001019663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019663", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBI7", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI7-2", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERERLVLKVTALQACIRGFLVRRQFQSLRGEYEAIVQEIEGDLGTLQWTEGWIPRPRFLPKKAKSCQTWKATGERAPNPEQELWSRFACKETEKETIREDMILKKSGESFTNASSLPCRDASAWSQDEQSRRTGKPSQETRDVSRKNDPEAAGPGLFHSQTELQELQNHRSHLAMELLWLQQAINSRKEYLVLKQTLRSPEVNQNRHEPSLCQEHGGQSCEKAGSQPGPPLEDQPYRGRTPGEPGHVDASCWRLRSQAHKFPEGLATPDKITAGAKYRDPSYRWPGPQLPTLSEYQATGKRLTKELDCGEEISGETCLQLTTLLEDESHKELKSKGSCPGKARTQLPTLHKDPNIEDNSPRGPCPKELDWQRAVPQELGVSEDHVTWDGSLAEHGGLDLWKNKPPKGQTPSDKSSIERSPSESSHEGWQNQRAVPFRSRPPEKLSTGSGHTGEDHWRGRQWKTGPAG", "length": 468, "header": "sp|Q2TBI7-1|IQCC_BOVIN Isoform 1 of IQ domain-containing protein C OS=Bos taurus OX=9913 GN=IQCC PE=2 SV=1 CANONICAL=Q2TBI7-1" }, "isoforms": [ { "isoform_ac": "Q2TBI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7/entry#Q2TBI7-1", "sequence": { "sequence": "MERERLVLKVTALQACIRGFLVRRQFQSLRGEYEAIVQEIEGDLGTLQWTEGWIPRPRFLPKKAKSCQTWKATGERAPNPEQELWSRFACKETEKETIREDMILKKSGESFTNASSLPCRDASAWSQDEQSRRTGKPSQETRDVSRKNDPEAAGPGLFHSQTELQELQNHRSHLAMELLWLQQAINSRKEYLVLKQTLRSPEVNQNRHEPSLCQEHGGQSCEKAGSQPGPPLEDQPYRGRTPGEPGHVDASCWRLRSQAHKFPEGLATPDKITAGAKYRDPSYRWPGPQLPTLSEYQATGKRLTKELDCGEEISGETCLQLTTLLEDESHKELKSKGSCPGKARTQLPTLHKDPNIEDNSPRGPCPKELDWQRAVPQELGVSEDHVTWDGSLAEHGGLDLWKNKPPKGQTPSDKSSIERSPSESSHEGWQNQRAVPFRSRPPEKLSTGSGHTGEDHWRGRQWKTGPAG", "length": 468, "header": "sp|Q2TBI7-1|IQCC_BOVIN Isoform 1 of IQ domain-containing protein C OS=Bos taurus OX=9913 GN=IQCC PE=2 SV=1 CANONICAL=Q2TBI7-1" }, "locus": {} }, { "isoform_ac": "Q2TBI7-2", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7/entry#Q2TBI7-2", "sequence": { "sequence": "MLNQNVQILGGFSLGALTPLISQKAKSCQTWKATGERAPNPEQELWSRFACKETEKETIREDMILKKSGESFTNASSLPCRDASAWSQDEQSRRTGKPSQETRDVSRKNDPEAAGPGLFHSQTELQELQNHRSHLAMELLWLQQAINSRKEYLVLKQTLRSPEVNQNRHEPSLCQEHGGQSCEKAGSQPGPPLEDQPYRGRTPGEPGHVDASCWRLRSQAHKFPEGLATPDKITAGAKYRDPSYRWPGPQLPTLSEYQATGKRLTKELDCGEEISGETCLQLTTLLEDESHKELKSKGSCPGKARTQLPTLHKDPNIEDNSPRGPCPKELDWQRAVPQELGVSEDHVTWDGSLAEHGGLDLWKNKPPKGQTPSDKSSIERSPSESSHEGWQNQRAVPFRSRPPEKLSTGSGHTGEDHWRGRQWKTGPAG", "length": 429, "header": "sp|Q2TBI7-2|IQCC_BOVIN Isoform 2 of IQ domain-containing protein C OS=Bos taurus OX=9913 GN=IQCC PE=2 SV=1 CANONICAL=Q2TBI7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI7", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507606", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507606", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 468, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBI7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI7" }, { "id": "PRU00116", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQ", "eco_id": "ECO_0000255", "start_pos": 6, "end_pos": 35, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2TBJ9-1", "uniprot_ac": "Q2TBJ9", "uniprot_id": "CABS1_BOVIN", "mass": { "chemical_mass": 42773.0, "monoisotopic_mass": 42773.0 }, "refseq": { "ac": "NP_001035629", "name": "calcium-binding and spermatid-specific protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" }, "gene_names": [ { "name": "CABS1", "type": "recommended", "evidence": [ { "id": "Q2TBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ] }, { "name": "C6H4ORF35", "type": "synonym", "evidence": [ { "id": "NP_001035629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" } ] }, { "name": "CABS1", "type": "synonym", "evidence": [ { "id": "NP_001035629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" } ] }, { "name": "CLPH", "type": "synonym", "evidence": [ { "id": "NP_001035629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" } ] } ], "protein_names": [ { "name": "Calcium-binding and spermatid-specific protein 1", "type": "recommended", "evidence": [ { "id": "Q2TBJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9/entry#names_and_taxonomy" } ] }, { "name": "calcium-binding and spermatid-specific protein 1", "type": "synonym", "evidence": [ { "id": "NP_001035629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" } ] }, { "name": "casein-like phosphoprotein", "type": "synonym", "evidence": [ { "id": "NP_001035629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629" } ] } ], "function": [ { "annotation": "Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9#function" }, { "database": "UniProtKB", "id": "Q8C633", "url": "https://www.uniprot.org/uniprotkb/Q8C633#function" }, { "database": "UniProtKB", "id": "Q68FX6", "url": "https://www.uniprot.org/uniprotkb/Q68FX6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CABS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9", "locus": { "chromosome": "6", "start_pos": 85736670, "end_pos": 85734578, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019849", "url": "https://www.ensembl.org/id/ENSBTAG00000019849" } ] } } ], "crossref": [ { "id": "Q2TBJ9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519098", "url": "https://www.ncbi.nlm.nih.gov/gene/519098", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519098", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519098", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEVNVWM", "url": "https://omabrowser.org/oma/group/DEVNVWM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBJ9", "url": "https://www.orthodb.org/?gene=Q2TBJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22810", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22810", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22810:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22810:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035629", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEDGLPKIYSHPPAESTKTTTEATIFFGADNTIPKSETTITSEGDHVTSVNDYMLENDFSTTTGNKLIPPKERQKSEDDVESHLEKEFATLMDIKNPMANESITENFLPVKTGNISSTDAISLIDFSTDIAKEDILLDTIDPGDKDVSLTSEVSGTPKESTAAIADTPILPNIMGKSDVSNYSSSVKFKVPADGNAHITDSSVPEAEITPTTERNLTTIPDITALTEEKITEIDLILPENDPNVVPKLTDSDEEKFITVFELTTTAERDKDNPEDALLTDEESTDEVSVWMERDMANEEESHSVLLTAVESRYDFVIPASVTMNLTEDLLTEEDLPENNRMESVTKNTDELSGTTPDLDAFSHKEDNFTTETGVFKLLKEEPDEFLI", "length": 388, "header": "sp|Q2TBJ9-1|CABS1_BOVIN Isoform 1 of Calcium-binding and spermatid-specific protein 1 OS=Bos taurus OX=9913 GN=CABS1 PE=2 SV=1 CANONICAL=Q2TBJ9-1" }, "isoforms": [ { "isoform_ac": "Q2TBJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9/entry#Q2TBJ9-1", "sequence": { "sequence": "MAEDGLPKIYSHPPAESTKTTTEATIFFGADNTIPKSETTITSEGDHVTSVNDYMLENDFSTTTGNKLIPPKERQKSEDDVESHLEKEFATLMDIKNPMANESITENFLPVKTGNISSTDAISLIDFSTDIAKEDILLDTIDPGDKDVSLTSEVSGTPKESTAAIADTPILPNIMGKSDVSNYSSSVKFKVPADGNAHITDSSVPEAEITPTTERNLTTIPDITALTEEKITEIDLILPENDPNVVPKLTDSDEEKFITVFELTTTAERDKDNPEDALLTDEESTDEVSVWMERDMANEEESHSVLLTAVESRYDFVIPASVTMNLTEDLLTEEDLPENNRMESVTKNTDELSGTTPDLDAFSHKEDNFTTETGVFKLLKEEPDEFLI", "length": 388, "header": "sp|Q2TBJ9-1|CABS1_BOVIN Isoform 1 of Calcium-binding and spermatid-specific protein 1 OS=Bos taurus OX=9913 GN=CABS1 PE=2 SV=1 CANONICAL=Q2TBJ9-1" }, "locus": { "chromosome": "6", "start_pos": 85736670, "end_pos": 85736566, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026444.4", "url": "https://www.ensembl.org/id/ENSBTAT00000026444.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026444.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026444.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "site_lbl": "Thr280" }, { "start_pos": 312, "end_pos": 312, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "site_lbl": "Ser312" }, { "start_pos": 344, "end_pos": 344, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "site_lbl": "Ser344" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519098", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519098", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ARG0-1", "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "CABS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEDGFQKIYSQPPTESTKTTTETTIFFGADNTIPKSESTITSEGDHITSVNDYMLESDFSTTTSNKLTSPKERLTSEDDVESHLEKELATLMDTKNPMANESITENFMPVKTGNISPPAEVSLIDFSTDVAKEAILVDTTEPGDEDVSLTFEVSGTLKESTASIADTPALPAKMGEPDGNNYSSLVKSNVTADDTVQITESSIPEAKISPATEKNSTIPDIIALPEETITEIDLILPEDGPNARADSDEEKFITVFELTTTIERDNDNPEDILLTDEESTDGVNTWMGRDKAKEAENHPVLLTAVESRYDFVVPVSVAMNLMDSHEFIADSAAMTKDDLSENNRMESLSKDTEALSGTTPDPDTLNHKEDAFTTEMGVFKLLKEEPDEFLI", "length": 392 }, "evidence": [ { "id": "Q2TBJ9", "url": "https://omabrowser.org/oma/group/Q2TBJ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FX6-1", "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "Cabs1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEDGSPKIYSRPPRDSSKTPTEADIFFGADNTIPKSETTITSEGDHITSVNDCTADGDFSTTVNKLTPTKEKLKLEEDIEASLKSTTLPEKEITTPTETTNSKPKESITENFIPVKIGNISSPVGTVSLIDFSSNMAKEDILLATIDAEDKEVKPTTELSETQEDSSANDEDTSVPPDENTETDVSSSTSSDVPDDGAVQVTDSFSPESDVPPSTEKEVTTIPDNVAEDKVTKIDLIVSEDRPKTVTKLSDSEEEKFITVFELTNSAEKAKDNPEDPLTDEEPADGVNTWVEKDAANEAESHAVLLTAVESRYDFVVTASETNSVVVEEPHVDTKNSPEKDAAESVTNVTEEFPSVTSVVEQSGNKEDLSTNDSGIFKLLKEEPDELMM", "length": 390 }, "evidence": [ { "id": "Q2TBJ9", "url": "https://omabrowser.org/oma/group/Q2TBJ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C633-1", "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "Cabs1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEDGSPKIYSRPPRDNSKTPTEADIFFGADNTIPKSETTITSEGDHVTSVNDCTPDGDFSTTVNKLTPTKEKLKLEDDIEGCLKLTTLPEKEITTPTETPNSKPKGSITENFIPVKIGNTSSPVGTVSLIDFSSNTAKEDIFLTTIDTGEKEVVPTTEFSGTLEDSAADVEDASGFPDESTETDVPSSATSDAPDDGAVQVTDSFSPEAGVPPSTEKEVTTIPDITNIAEENVTEIKLIVSEDRPKTVTKLSDSEEEKFITVFELTNSAEKAKDNVEDPLNDEESTDGANDWMEKETASEAESHAVLLTAVESRYDFIVTASETDNVMEESHVNTTDLPENETTESVTNVTEELPSVTSIVDTLKDKEDLSTTNSGLFKLLKEEPDDLMM", "length": 391 }, "evidence": [ { "id": "Q2TBJ9", "url": "https://omabrowser.org/oma/group/Q2TBJ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96KC9-1", "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "CABS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEDGLPKIYSHPPTESSKTPTAATIFFGADNAIPKSETTITSEGDHVTSVNEYMLESDFSTTTDNKLTAKKEKLKSEDDMGTDFIKSTTHLQKEITSLTGTTNSITRDSITEHFMPVKIGNISSPVTTVSLIDFSTDIAKEDILLATIDTGDAEISITSEVSGTLKDSSAGVADAPAFPRKKDEADMSNYNSSIKSNVPADEAVQVTDSTIPEAEIPPAPEESFTTIPDITALEEEKITEIDLSVLEDDTSAVATLTDSDEKFITVFELTTSAEKDKDKREDTLLTDEETTEGASIWMERDTANEAETHSVLLTAVESRYDFVVPASIATNLVEESSTEEDLSETDNTETVPKITEPFSGTTSVLDTPDYKEDTSTTETDIFELLKEEPDEFMI", "length": 395 }, "evidence": [ { "id": "Q2TBJ9", "url": "https://omabrowser.org/oma/group/Q2TBJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q2TBJ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 388, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBJ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 280, 312, 344 ], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 115, "end_pos": 117 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 325, "end_pos": 327 }, { "start_pos": 368, "end_pos": 370 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBK3-1", "uniprot_ac": "Q2TBK3", "uniprot_id": "PLAC9_BOVIN", "mass": { "chemical_mass": 10747.0, "monoisotopic_mass": 10747.0 }, "refseq": { "ac": "NP_001033610", "name": "placenta-specific protein 9 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610" }, "gene_names": [ { "name": "PLAC9", "type": "recommended", "evidence": [ { "id": "Q2TBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3" } ] }, { "name": "PLAC9", "type": "synonym", "evidence": [ { "id": "NP_001033610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610" } ] } ], "protein_names": [ { "name": "Placenta-specific protein 9", "type": "recommended", "evidence": [ { "id": "Q2TBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3/entry#names_and_taxonomy" } ] }, { "name": "placenta specific 9", "type": "synonym", "evidence": [ { "id": "NP_001033610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610" } ] }, { "name": "placenta-specific protein 9 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610" } ] }, { "name": "placenta-specific protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBK3", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLAC9", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3", "locus": { "chromosome": "28", "start_pos": 35166730, "end_pos": 35179137, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020939", "url": "https://www.ensembl.org/id/ENSBTAG00000020939" } ] } } ], "crossref": [ { "id": "Q2TBK3", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510496", "url": "https://www.ncbi.nlm.nih.gov/gene/510496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CDTHVAV", "url": "https://omabrowser.org/oma/group/CDTHVAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBK3", "url": "https://www.orthodb.org/?gene=Q2TBK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37355:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37355:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033610", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBK3", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBK3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLLCALAGLALLRAPGAFAADEPFIPSRGDSAQSTGCDTYMAVHSRLDVIEETVEKTVEHLEAEVKGLLGQLEELAWNLPPGPFSPIPDLLGDGDDRF", "length": 100, "header": "sp|Q2TBK3-1|PLAC9_BOVIN Isoform 1 of Placenta-specific protein 9 OS=Bos taurus OX=9913 GN=PLAC9 PE=3 SV=1 CANONICAL=Q2TBK3-1" }, "isoforms": [ { "isoform_ac": "Q2TBK3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3/entry#Q2TBK3-1", "sequence": { "sequence": "MRLLLCALAGLALLRAPGAFAADEPFIPSRGDSAQSTGCDTYMAVHSRLDVIEETVEKTVEHLEAEVKGLLGQLEELAWNLPPGPFSPIPDLLGDGDDRF", "length": 100, "header": "sp|Q2TBK3-1|PLAC9_BOVIN Isoform 1 of Placenta-specific protein 9 OS=Bos taurus OX=9913 GN=PLAC9 PE=3 SV=1 CANONICAL=Q2TBK3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510496", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LPB6-1", "protein_name": "Placenta associated 9", "gene_name": "Plac9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERLPLRWDPGLRLLSGYGGASRGGGQVLWSQNPEPPRNFGSDCISSGRAGAIPRRRLRTNGCTRWLPTMQPLLCALAGLALLRAGAGEWSQGPRDIPGRRDPLSSSWTTEVFLEARGHNISWNWRYIAGSFRRPIKLTAAESPSGPGEDLAWSPGCDRHMAVQGRLNIVEETVEKTVEHLEAEVTGLLGLLEELASNLPPGPFSPKPDLLGDDGF", "length": 216 }, "evidence": [ { "id": "Q2TBK3", "url": "https://omabrowser.org/oma/group/Q2TBK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SER5-1", "protein_name": "Placenta associated 9", "gene_name": "PLAC9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPLLCALAGLALLRAAGAYAAAAEPFIPSGGDPSRSTACDRYMAIHSRLNVIEETVEKTVEHLEAEVKGLLGQLEELAWNLPPGPFSPIPDLLGDGDSS", "length": 100 }, "evidence": [ { "id": "Q2TBK3", "url": "https://omabrowser.org/oma/group/Q2TBK3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5JTB6-1", "protein_name": "Placenta-specific protein 9", "gene_name": "PLAC9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPLLCALTGLALLRAAGSLAAAEPFSPPRGDSAQSTACDRHMAVQRRLDVMEEMVEKTVDHLGTEVKGLLGLLEELAWNLPPGPFSPAPDLLGDGF", "length": 97 }, "evidence": [ { "id": "Q2TBK3", "url": "https://omabrowser.org/oma/group/Q2TBK3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K262-1", "protein_name": "Placenta-specific protein 9", "gene_name": "Plac9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQALLCALAGLALLRAGTGEWGQGPRDTPGRRAAESPSSPGDLAGSPGCDRHAAVQRRLDIMEETVEKTVEHLEAEVTGLLGLLEELASNLPTGPFSPKPDLLGDDGF", "length": 108 }, "evidence": [ { "id": "Q2TBK3", "url": "https://omabrowser.org/oma/group/Q2TBK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK3", "url": "https://www.uniprot.org/uniprotkb/Q2TBK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBK3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 100, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBK3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBK3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBM9-1", "uniprot_ac": "Q2TBM9", "uniprot_id": "SRAC1_BOVIN", "mass": { "chemical_mass": 74196.0, "monoisotopic_mass": 74196.0 }, "refseq": { "ac": "NP_001033639", "name": "protein SERAC1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033639" }, "gene_names": [ { "name": "SERAC1", "type": "recommended", "evidence": [ { "id": "Q2TBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ] }, { "name": "SERAC1", "type": "synonym", "evidence": [ { "id": "NP_001033639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033639" } ] } ], "protein_names": [ { "name": "Protein SERAC1", "type": "recommended", "evidence": [ { "id": "Q2TBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#names_and_taxonomy" } ] }, { "name": "Serine active site-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q2TBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#names_and_taxonomy" } ] }, { "name": "protein SERAC1", "type": "synonym", "evidence": [ { "id": "NP_001033639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033639" } ] }, { "name": "serine active site-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033639" } ] } ], "function": [ { "annotation": "Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication. Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway. May have acyltransferase activity although the mechanism for PG remodeling has not been determined.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9#function" }, { "database": "UniProtKB", "id": "Q96JX3", "url": "https://www.uniprot.org/uniprotkb/Q96JX3#function" }, { "database": "UniProtKB", "id": "A0A3Q1MKP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKP1#function" }, { "database": "UniProtKB", "id": "ARBA00093375", "url": "https://www.uniprot.org/uniprotkb/ARBA00093375#function" }, { "database": "UniProtKB", "id": "A0AAA9SDP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP1#function" }, { "database": "UniProtKB", "id": "A0AAA9TWR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWR7#function" }, { "database": "UniProtKB", "id": "A0A3Q1LNR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNR3#function" }, { "database": "UniProtKB", "id": "A0AAF6ZTB6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERAC1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9", "locus": { "chromosome": "9", "start_pos": 94662437, "end_pos": 94714692, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011509", "url": "https://www.ensembl.org/id/ENSBTAG00000011509" } ] } } ], "crossref": [ { "id": "Q2TBM9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011509", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011509", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519860", "url": "https://www.ncbi.nlm.nih.gov/gene/519860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519860", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRTEYIY", "url": "https://omabrowser.org/oma/group/RRTEYIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNR3", "url": "https://www.orthodb.org/?gene=A0A3Q1LNR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MKP1", "url": "https://www.orthodb.org/?gene=A0A3Q1MKP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBM9", "url": "https://www.orthodb.org/?gene=Q2TBM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48182", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48182", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48182:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48182:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033639", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKP1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWI7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTB6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBM9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRNIIKFTGSLILGGSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHGITYQARKELHKAVRKVLATSARIFRGPFADTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 654, "header": "sp|Q2TBM9-1|SRAC1_BOVIN Isoform 1 of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=2 SV=1 CANONICAL=Q2TBM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNR3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0A3Q1LNR3-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRITYQARKELHKAVRKVLATSARIFRGPFADTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 596, "header": "tr|A0A3Q1LNR3-1|A0A3Q1LNR3_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068857.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068857.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061674.1" } ] } }, { "isoform_ac": "A0A3Q1MKP1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0A3Q1MKP1-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRNIIKFTGSLILGGSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHGITYQARKELHKAVRKVLATSARIFRGPFADYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 610, "header": "tr|A0A3Q1MKP1-1|A0A3Q1MKP1_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073645.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073645.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071479.1" } ] } }, { "isoform_ac": "A0AAA9SDP1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0AAA9SDP1-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDINTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 566, "header": "tr|A0AAA9SDP1-1|A0AAA9SDP1_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126337.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126337.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083514.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083514.1" } ] } }, { "isoform_ac": "A0AAA9TWR7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0AAA9TWR7-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDISSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHDTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 611, "header": "tr|A0AAA9TWR7-1|A0AAA9TWR7_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124806.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124806.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101909.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101909.1" } ] } }, { "isoform_ac": "A0AAF6YWI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0AAF6YWI7-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRNIIKFTGSLILGGSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHGITYQARKELHKAVRKVLATSARIFRGPFADTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSI", "length": 609, "header": "tr|A0AAF6YWI7-1|A0AAF6YWI7_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663441, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015295.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015295.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015295.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015295.4" } ] } }, { "isoform_ac": "A0AAF6ZTB6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#A0AAF6ZTB6-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRNIIKFTGSLILGGSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHDTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 624, "header": "tr|A0AAF6ZTB6-1|A0AAF6ZTB6_BOVIN Computationally mapped isoform of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=3 SV=1 CANONICAL=Q2TBM9-1" }, "locus": { "chromosome": "9", "start_pos": 94701355, "end_pos": 94663310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075870.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075870.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057129.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057129.2" } ] } }, { "isoform_ac": "Q2TBM9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9/entry#Q2TBM9-1", "sequence": { "sequence": "MSLAAYCVICCRRMGTSTPPPKSSTYWRDIRNIIKFTGSLILGGSLFITYEVLALKKSLTLDTQVIEREKMKSYIYVHTVSLDKTENHGITYQARKELHKAVRKVLATSARIFRGPFADTFSTVDIEDHDCAVWLLLRKSRSDDRAARLQAVQEMSEARHWHDYQYRIIAQACDMRTLTGLARSKDSDLRFFLRPPPLPSLKEDSSTEEELRHLLASLPQTDLDECIQCFTALALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEALVKHSEIPTHCDKIEANGGLQLLQRLYQLHKDCPKVQRNIMRILGNMALNEHLHSTIVRSGWVSILAEAIKSQHIMEASHAARTLANLDRETVPDKYHDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDNDQDLTEKVSEDETKYTTCWPKSWLARDCPALRIISVEYDTSLSDWRARCPTERKSIAFRSNELLRKLRAAGVGDRPVVWVSHSMGGLLVKKMLLEASKRPEMNTIINNTRGIIFYSVPHHGSHLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLSFVETLPTYIGSMIKLHVVPLDSADLGLGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIRDALAKDLEN", "length": 654, "header": "sp|Q2TBM9-1|SRAC1_BOVIN Isoform 1 of Protein SERAC1 OS=Bos taurus OX=9913 GN=SERAC1 PE=2 SV=1 CANONICAL=Q2TBM9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519860", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519860", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6B543-1", "protein_name": "Protein SERAC1", "gene_name": "Serac1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLAASYCVICCRRIGTFVPRSKSHTSWRNIRNIVRFTGSLIVGGSLFITYQVLALKKSLTLDTQVVEREKMKSYIYVHKALVDSLDNHGIVWQARKELHRAVRKVLAAAAKVLRSPFAGPFSTVDIEDHDCAVWLLLRKSRQDDLAARLEAVREMSEAHHWHDYQYRIIAQACDPRTLIGLARSKESDLRFFLPPPPLPSLKEDSSTEEEFGHLLASLPQTELDECLQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGETPSATVEMLSLEAIVKHSEIPSHCDYIEAGGGLQLLQRLYQLHKDCPKIQRSVLRIIGNMALNEHLHPAIVHSGWVSLLAEALKSCHIMEASHAARTLANLDRETVSEKYQDGVYVLHPQCRTSQPIKADVLFIHGLMGAAFKTWRQHDSQRALTENALVDEDSYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLSKLRAAGVGERPVIWVSHSMGGLLVKKMLLEASQKPELSALINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKMLQDEFLELVKDKDLQVLNFVETQPTFIGSMIKLQVVPVESADLGIGDLIPVDVNHLNICKPKTKDAFLYQRTLQFICETLARDLEN", "length": 655 }, "evidence": [ { "id": "Q2TBM9", "url": "https://omabrowser.org/oma/group/Q2TBM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U213-1", "protein_name": "Protein SERAC1", "gene_name": "Serac1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLAAYCVICCRRIGSFAPRSKSRTPWRNIRNIIRFTGSLIVGGSLFITYEVLALKKSLMLDTQVVEREKMKSYIYVHKAPVDRLDNRGIVWQARKELHRAVRKLLAAAAKVLRSPFADSFSTVDIEDHDCAVWLLLRKSREDDLAARLQAVREMSEAHHWHDYQYRIIAQACDPRTLIGLARSKESDLRFFLPPPPLPSLKEDSSTEEELRHLLASLPQTELDECLQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGKVPSATVEMFCLEAIVKHSEIPSHCDHIEAGGGLQLLQRLYQLHKDCPKVQRNVMRIIGNMALNEHLHPAIVHSGWVSLMAEALKSSHIMEASHAARTLANLDRETVGEKYQDGVYVLHPQCRTSQPIKADVLFIHGLMGAAFKTWRQHDSQRALTESAVVDEDRYTTCWPKTWLAKDCPSLRIISVEYDTSLSDWRARCPMERKSIAFRSNELLSKLRAAGVGDRPMIWISHSMGGLLVKKMLLEASKKPELNALINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETQPTFIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKTKDAFLYQRTLQFICETLARDLEN", "length": 654 }, "evidence": [ { "id": "Q2TBM9", "url": "https://omabrowser.org/oma/group/Q2TBM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5SNQ7-1", "protein_name": "Protein SERAC1", "gene_name": "serac1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVSALRLIRVRRLSTSGPAVKRALPWRDIRRIAKVTGAIVFGGCVFITYEVVTLNQALTIDTSAILQEKQKSYIYPTHSTNREQESLASGLTIKTRRELHKAARKFLEITSRVLHHPLDEHLSHLDADPHECALWVLLKRSRSADRAVRHLAVQELAHNHHWRDYQYQTAAQVVDQRTAVALARIPNVDLRFFLPPPPLPHTEDDISIEDGLRQLLASLPQSDVDQCVQYFTSLALRESSQSLASQRGGLWCFGGNGLPYAQSLTSTPSEKVETFCLQALVQHSKVRSHCEHIVANGGLQLLQRVYQLRRDSPKIQRNIVRIIGNLALNENLHTTIVQSGWMSVLAEMIQSPHIMQASHAARALANLDRDAVRQKYQDGVYILHPQCRTNQPIKADVLFVHGLLGAAFKTWRQKDCDVTDDEKLEGVREDYTECWPKSWLAADCPNLRILSVEYDTHLSDWNSKCPVENQRKSLAFRSQELLRKLKDAGVGERPVIWVAHSMGGLLVKKMLLDAAKDPDLSSLIKNTKGILFYSVPHHGTFMAEYSVSVRYLLFPSIEVKELCRDSPALRDLNENFLNIAKDREFKVLSFAETVPTYIGPMLKILVVPAHSADLGIGDLIQVDVDHLNICKPEKKDTFLYKRTLQFIQDALGGRRIK", "length": 658 }, "evidence": [ { "id": "Q2TBM9", "url": "https://omabrowser.org/oma/group/Q2TBM9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96JX3-1", "protein_name": "Protein SERAC1", "gene_name": "SERAC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVTLDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADPFSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIGLARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQLLQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAARILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVIEKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLRKLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN", "length": 654 }, "evidence": [ { "id": "Q2TBM9", "url": "https://omabrowser.org/oma/group/Q2TBM9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VJ64-1", "protein_name": "SERAC1 N-terminal domain-containing protein", "gene_name": "Dmel\\CG10383", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLEDLKIKLRRHPKLLGLGGVGLITAAGFLLYESPQVRRFLSQYVDKKSPEPDKRRAEYIYIKYHIYRESMRKLKQKEEDEKKWISVIINPIGKWWKAAKHSVAWRLLNIAQTGSQPERLKAVQQLICMDHLKDWDFRHLAQICDARTAVSLARCNADTRWFMPVPRRGCIKNPKMLLSELHVMLARLRPMACIDHFFSKYFPEQDPIEDIHEYLTQEQTIVLSTADTDLLKEIISFLHHITKDPEVSARLMRDGGLVHLMELRKIFNDDNETLSTLCKVLANMSLVPDAVEHFFTSGWVGALAEWQQCPDLRLQVISAKTMANLDHDDPNQCTYPPNVYPLHPRVRTRRKPKADIVFVHGLLGGVFITWRQRDRKPTELGLYGKNAFYTSETDDVFLVGEQKRLSGGKLKPGEAVKNVNGNQKTETIKDPVLKASKKVEEQRLNISDAATKEFVETLRNEAELDSDWEVVHPDVPLNANEECEGKFSVCGSEWRNQDTSEEYTNCWPMEWLPDDYPDSRILGIDYTSAVTEWSANFTKYCPCEKGQGHIDVRANTLLDRISASDVGNDRPIVWIGHSMGGLLTKLILLKSLDSQEPKVQQLTKNTKGIVFLGTPHRGSPIAKWKQHMQMILSPSIEVKEMEENSPKLLEMHRRFMGCLHTLLRHVKVVSVAEGSPTMLTSFKFPLRIVTEESSKIDFGDFYLLKDDHLSLSKPIYRQSFLYQRLLHVIREAIKERSDPKDQDGQSQSTSNQDVVLVKIVAALLEGAKGLFESLPRVALRFST", "length": 784 }, "evidence": [ { "id": "Q2TBM9", "url": "https://omabrowser.org/oma/group/Q2TBM9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "phosphatidylglycerol acyl-chain remodeling", "id": "GO:0036148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036148", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" }, { "name": "intracellular cholesterol transport", "id": "GO:0032367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032367", "evidence": [ { "database": "UniProtKB", "id": "Q2TBM9", "url": "https://www.uniprot.org/uniprotkb/Q2TBM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 654, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBM9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 522, "end_pos": 524 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBN4-1", "uniprot_ac": "Q2TBN4", "uniprot_id": "MED28_BOVIN", "mass": { "chemical_mass": 19764.0, "monoisotopic_mass": 19764.0 }, "refseq": { "ac": "NP_001033627", "name": "mediator of RNA polymerase II transcription subunit 28", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033627" }, "gene_names": [ { "name": "MED28", "type": "recommended", "evidence": [ { "id": "Q2TBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ] }, { "name": "MED28", "type": "synonym", "evidence": [ { "id": "NP_001033627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033627" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 28", "type": "recommended", "evidence": [ { "id": "Q2TBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 28", "type": "synonym", "evidence": [ { "id": "Q2TBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 28", "type": "synonym", "evidence": [ { "id": "NP_001033627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033627" } ] }, { "name": "mediator of RNA polymerase II transcription, subunit 28", "type": "synonym", "evidence": [ { "id": "NP_001033627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033627" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED28", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4", "locus": { "chromosome": "6", "start_pos": 37175026, "end_pos": 37157899, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019441", "url": "https://www.ensembl.org/id/ENSBTAG00000019441" } ] } } ], "crossref": [ { "id": "Q2TBN4", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "513972", "url": "https://www.ncbi.nlm.nih.gov/gene/513972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513972", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513972", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBN4", "url": "https://www.orthodb.org/?gene=Q2TBN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13512", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13512", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13512:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13512:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033627", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBN4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPLGGMFSGQQPGPPQPPPGLLGQASLLQATPGVPRTSNSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIKKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINMQHKKPADIPQGSLAYLEQASANIPAPMKQT", "length": 178, "header": "sp|Q2TBN4-1|MED28_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 28 OS=Bos taurus OX=9913 GN=MED28 PE=2 SV=1 CANONICAL=Q2TBN4-1" }, "isoforms": [ { "isoform_ac": "Q2TBN4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4/entry#Q2TBN4-1", "sequence": { "sequence": "MAAPLGGMFSGQQPGPPQPPPGLLGQASLLQATPGVPRTSNSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIKKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINMQHKKPADIPQGSLAYLEQASANIPAPMKQT", "length": 178, "header": "sp|Q2TBN4-1|MED28_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 28 OS=Bos taurus OX=9913 GN=MED28 PE=2 SV=1 CANONICAL=Q2TBN4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513972", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN4", "url": "https://www.uniprot.org/uniprotkb/Q2TBN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 41, "end_pos": 43 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBN5-1", "uniprot_ac": "Q2TBN5", "uniprot_id": "COMD9_BOVIN", "mass": { "chemical_mass": 21781.0, "monoisotopic_mass": 21781.0 }, "refseq": { "ac": "NP_001033609", "name": "COMM domain-containing protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033609" }, "gene_names": [ { "name": "COMMD9", "type": "recommended", "evidence": [ { "id": "Q2TBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ] }, { "name": "COMMD9", "type": "synonym", "evidence": [ { "id": "NP_001033609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033609" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 9", "type": "recommended", "evidence": [ { "id": "Q2TBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033609" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5#function" }, { "database": "UniProtKB", "id": "Q9P000", "url": "https://www.uniprot.org/uniprotkb/Q9P000#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5", "locus": { "chromosome": "15", "start_pos": 66742647, "end_pos": 66755667, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019045", "url": "https://www.ensembl.org/id/ENSBTAG00000019045" } ] } } ], "crossref": [ { "id": "Q2TBN5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510280", "url": "https://www.ncbi.nlm.nih.gov/gene/510280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510280", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510280", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBN5", "url": "https://www.orthodb.org/?gene=Q2TBN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15663:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15663:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033609", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBN5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALTAENFAALQSLLKASSKDVVRQLCQESFSSSALGSKNLLDVTCSSLSVTQEEAEQLLQALHRLTRLAVFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSAWRAEAQVNQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDRPSVSDVTVELSKETLDTMLDGLGRIRDQLSAVASK", "length": 198, "header": "sp|Q2TBN5-1|COMD9_BOVIN Isoform 1 of COMM domain-containing protein 9 OS=Bos taurus OX=9913 GN=COMMD9 PE=2 SV=1 CANONICAL=Q2TBN5-1" }, "isoforms": [ { "isoform_ac": "Q2TBN5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5/entry#Q2TBN5-1", "sequence": { "sequence": "MAALTAENFAALQSLLKASSKDVVRQLCQESFSSSALGSKNLLDVTCSSLSVTQEEAEQLLQALHRLTRLAVFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSAWRAEAQVNQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDRPSVSDVTVELSKETLDTMLDGLGRIRDQLSAVASK", "length": 198, "header": "sp|Q2TBN5-1|COMD9_BOVIN Isoform 1 of COMM domain-containing protein 9 OS=Bos taurus OX=9913 GN=COMMD9 PE=2 SV=1 CANONICAL=Q2TBN5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510280", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510280", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ], "pmid": "" }, { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN5", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBN5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBN5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN5" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 122, "end_pos": 196, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBP5-1", "uniprot_ac": "Q2TBP5", "uniprot_id": "TMM53_BOVIN", "mass": { "chemical_mass": 33161.0, "monoisotopic_mass": 33161.0 }, "refseq": { "ac": "NP_001033661", "name": "transmembrane protein 53", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033661" }, "gene_names": [ { "name": "TMEM53", "type": "recommended", "evidence": [ { "id": "Q2TBP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ] }, { "name": "TMEM53", "type": "synonym", "evidence": [ { "id": "NP_001033661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033661" } ] } ], "protein_names": [ { "name": "Transmembrane protein 53", "type": "recommended", "evidence": [ { "id": "Q2TBP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 53", "type": "synonym", "evidence": [ { "id": "NP_001033661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033661" } ] } ], "function": [ { "annotation": "Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5#function" }, { "database": "UniProtKB", "id": "Q6P2H8", "url": "https://www.uniprot.org/uniprotkb/Q6P2H8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM53", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5", "locus": { "chromosome": "3", "start_pos": 101389010, "end_pos": 101355060, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012372", "url": "https://www.ensembl.org/id/ENSBTAG00000012372" } ] } } ], "crossref": [ { "id": "Q2TBP5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012372", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012372", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540738", "url": "https://www.ncbi.nlm.nih.gov/gene/540738", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540738", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540738", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIG8", "url": "https://www.orthodb.org/?gene=A0A452DIG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBP5", "url": "https://www.orthodb.org/?gene=Q2TBP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12265", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12265", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12265:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12265:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIG8", "url": "https://www.uniprot.org/uniprotkb/A0A452DIG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIG8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAQLDYTIEIPDQPCRSQENSPDQGGKEAGTRLPLVILLGWGGCSDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSETLGIPSLRVLAQKLLELLFDYEVEKEPLLFHVFSNAGVMLYRYVLELLQTHQRFCHLRVVGTIFDSGPGDSNLLGALRALAVVLEHRPAALRLLLLVAFTLVAFLFHVLLAPLTALFHTHFYDRLLDAASRWPELYLYSRADEVVLARDVERMVEARLAHQVLVRSVDFVSSAHVSHLRDYPTYYTTLCINFMHSCVHCSGPCPPHLTSAPEINA", "length": 294, "header": "sp|Q2TBP5-1|TMM53_BOVIN Isoform 1 of Transmembrane protein 53 OS=Bos taurus OX=9913 GN=TMEM53 PE=2 SV=1 CANONICAL=Q2TBP5-1" }, "isoforms": [ { "isoform_ac": "A0A452DIG8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5/entry#A0A452DIG8-1", "sequence": { "sequence": "MASAQLDYTIEIPDQPCRSQENSPDQGGKEAGTRLPLVILLGWGGCSDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSETLGIPSLRVLAQKLLELLFDYEVEKEPLLFHVFSNAGVMLYRYVLELLQTHQRFCHLRVVGTIFDSGPGDSNLLGALRALAVVLEHRPAALRLLLLVAFTLVAFLFHVLLAPLTALFHTHFYDRLLDAASRWPELYLYSRADEVVLARDVERMVEARLAHQVLVRSVDFVSSAHVSHLRDYPTYYTTLCINFMHSCVHCSGAPAGLPDGCIPVSEMLQIHHSSSPWLSLPCLSPSNLRKALTTTPSGTGLLHGLLFAALAVAGRWHLCRDREGTHTLARWAAQPFLHCLLLQVVSAHKPAHSYIMSSPQETPSLGLLSTCLPHLGRVGRGQTGLQGHPNPGPGHPVPHGPAWQVYPGESRLAKACQSHTAEPSANVLILAGRSLPAKTPGSCSN", "length": 473, "header": "tr|A0A452DIG8-1|A0A452DIG8_BOVIN Computationally mapped isoform of Transmembrane protein 53 OS=Bos taurus OX=9913 GN=TMEM53 PE=3 SV=2 CANONICAL=Q2TBP5-1" }, "locus": { "chromosome": "3", "start_pos": 101381192, "end_pos": 101355102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016415.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016415.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016415.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016415.6" } ] } }, { "isoform_ac": "A0AAA9SIK1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5/entry#A0AAA9SIK1-1", "sequence": { "sequence": "MASAQLDYTIEIPDQPCRSQENSPDQGGKEAGTRLPLVILLGWGGCSDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSETLGIPSLRVLAQKLLELLFDYEVEKEPLLFHVFSNAGVMLYRYVLELLQTHQRFCHLRVVGTIFDSGPGDSNLLGALRALAVVLEHRPAALRLLLLVAFTLVAFLFHVLLAPLTALFHTHFYDRLLDAASRWPELYLYSRADEVVLARDVERMVEARLAHQVLVRSVDFVSSAHVSHLRDYPTYYTTLCINFMHSCVHCSGAPAGLPDGCIPVSEMLQIHHSSSPWLSLPCLSPSNLRKALTTTPSGTGLLHGLLFAALAVAGRWHLCRDREGTHTLARWAAQWFWSRTTSHEPVQEPCWGHKGLKATGSGVLTRLGCHLQCITRGGEPPSSLLACSLTIPFPHPNTSILICTSQAGSTVTKKPCQQQFPRGRMDDQPPALASWLPQMATQQRPGRHSATA", "length": 480, "header": "tr|A0AAA9SIK1-1|A0AAA9SIK1_BOVIN Computationally mapped isoform of Transmembrane protein 53 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q2TBP5-1" }, "locus": { "chromosome": "3", "start_pos": 101388708, "end_pos": 101355102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091421.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091421.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083750.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083750.1" } ] } }, { "isoform_ac": "Q2TBP5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5/entry#Q2TBP5-1", "sequence": { "sequence": "MASAQLDYTIEIPDQPCRSQENSPDQGGKEAGTRLPLVILLGWGGCSDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSETLGIPSLRVLAQKLLELLFDYEVEKEPLLFHVFSNAGVMLYRYVLELLQTHQRFCHLRVVGTIFDSGPGDSNLLGALRALAVVLEHRPAALRLLLLVAFTLVAFLFHVLLAPLTALFHTHFYDRLLDAASRWPELYLYSRADEVVLARDVERMVEARLAHQVLVRSVDFVSSAHVSHLRDYPTYYTTLCINFMHSCVHCSGPCPPHLTSAPEINA", "length": 294, "header": "sp|Q2TBP5-1|TMM53_BOVIN Isoform 1 of Transmembrane protein 53 OS=Bos taurus OX=9913 GN=TMEM53 PE=2 SV=1 CANONICAL=Q2TBP5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540738", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540738", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" }, { "name": "nuclear outer membrane", "id": "GO:0005640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005640", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of nucleocytoplasmic transport", "id": "GO:0046822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046822", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" }, { "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" }, { "name": "negative regulation of ossification", "id": "GO:0030279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP5", "url": "https://www.uniprot.org/uniprotkb/Q2TBP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBP5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 294, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBP5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBP5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBP7-1", "uniprot_ac": "Q2TBP7", "uniprot_id": "MYCBP_BOVIN", "mass": { "chemical_mass": 11997.0, "monoisotopic_mass": 11997.0 }, "refseq": { "ac": "NP_001033654", "name": "C-Myc-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" }, "gene_names": [ { "name": "MYCBP", "type": "recommended", "evidence": [ { "id": "Q2TBP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ] }, { "name": "AMY-1", "type": "synonym", "evidence": [ { "id": "NP_001033654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" } ] }, { "name": "AMY1", "type": "synonym", "evidence": [ { "id": "Q2TBP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ] }, { "name": "MYCBP", "type": "synonym", "evidence": [ { "id": "NP_001033654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" } ] } ], "protein_names": [ { "name": "c-Myc-binding protein", "type": "recommended", "evidence": [ { "id": "Q2TBP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7/entry#names_and_taxonomy" } ] }, { "name": "AMY-1", "type": "synonym", "evidence": [ { "id": "Q2TBP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7/entry#names_and_taxonomy" } ] }, { "name": "Associate of Myc 1", "type": "synonym", "evidence": [ { "id": "Q2TBP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7/entry#names_and_taxonomy" } ] }, { "name": "C-Myc-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001033654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" } ] }, { "name": "associate of Myc 1", "type": "synonym", "evidence": [ { "id": "NP_001033654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" } ] }, { "name": "c-myc binding protein", "type": "synonym", "evidence": [ { "id": "NP_001033654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654" } ] } ], "function": [ { "annotation": "May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYCBP", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7", "locus": { "chromosome": "3", "start_pos": 107117818, "end_pos": 107111729, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030337", "url": "https://www.ensembl.org/id/ENSBTAG00000030337" } ] } } ], "crossref": [ { "id": "Q2TBP7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21937", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21937", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539291", "url": "https://www.ncbi.nlm.nih.gov/gene/539291", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539291", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539291", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP7", "url": "https://www.orthodb.org/?gene=Q2TBP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13168", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13168", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13168:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13168:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001033654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKTKLAQYEPPQEEKRAE", "length": 103, "header": "sp|Q2TBP7-1|MYCBP_BOVIN Isoform 1 of c-Myc-binding protein OS=Bos taurus OX=9913 GN=MYCBP PE=3 SV=3 CANONICAL=Q2TBP7-1" }, "isoforms": [ { "isoform_ac": "Q2TBP7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7/entry#Q2TBP7-1", "sequence": { "sequence": "MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKTKLAQYEPPQEEKRAE", "length": 103, "header": "sp|Q2TBP7-1|MYCBP_BOVIN Isoform 1 of c-Myc-binding protein OS=Bos taurus OX=9913 GN=MYCBP PE=3 SV=3 CANONICAL=Q2TBP7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539291", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539291", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 103, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBP7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBQ4-1", "uniprot_ac": "Q2TBQ4", "uniprot_id": "TM270_BOVIN", "mass": { "chemical_mass": 28644.0, "monoisotopic_mass": 28644.0 }, "refseq": { "ac": "NP_001069914", "name": "transmembrane protein 270", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" }, "gene_names": [ { "name": "TMEM270", "type": "recommended", "evidence": [ { "id": "Q2TBQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4" } ] }, { "name": "TMEM270", "type": "synonym", "evidence": [ { "id": "NP_001069914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" } ] }, { "name": "WBSCR28", "type": "synonym", "evidence": [ { "id": "NP_001069914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" } ] } ], "protein_names": [ { "name": "Transmembrane protein 270", "type": "recommended", "evidence": [ { "id": "Q2TBQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4/entry#names_and_taxonomy" } ] }, { "name": "Williams-Beuren syndrome chromosome region 28", "type": "synonym", "evidence": [ { "id": "NP_001069914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" } ] }, { "name": "transmembrane protein 270", "type": "synonym", "evidence": [ { "id": "NP_001069914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" } ] }, { "name": "williams-Beuren syndrome chromosomal region 28 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001069914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ4", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM270", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4", "locus": { "chromosome": "25", "start_pos": 33446069, "end_pos": 33448575, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014810", "url": "https://www.ensembl.org/id/ENSBTAG00000014810" } ] } } ], "crossref": [ { "id": "Q2TBQ4", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "617180", "url": "https://www.ncbi.nlm.nih.gov/gene/617180", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617180", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617180", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBQ4", "url": "https://www.orthodb.org/?gene=Q2TBQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37369:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37369:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15164", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15164", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBQ4", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAIPLVRSSLSGTLLVVVKLSALLIQNRAHLYNFLLLKIFLFNHWLLGLTQEAQGFHPPSKIAGCPVGRVLWAGLTLLEVPVCLALRVPRLVWAGLLGCARALGLGPKWLGAWEQLGLSAATWTDLFLSCLHSLMLAALLLLLLVWRLYQKAQCCSLGRLPRKALLQNRVVRRSLALLKSLYWWVESTAALTSWHLAYLITWTTCLASHLLQAAFEHTAQLAQAQEAEPQKALGLSSETPPPGPPAPGARPVLPEPGTPGE", "length": 262, "header": "sp|Q2TBQ4-1|TM270_BOVIN Isoform 1 of Transmembrane protein 270 OS=Bos taurus OX=9913 GN=TMEM270 PE=2 SV=1 CANONICAL=Q2TBQ4-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4/entry#Q2TBQ4-1", "sequence": { "sequence": "MEAIPLVRSSLSGTLLVVVKLSALLIQNRAHLYNFLLLKIFLFNHWLLGLTQEAQGFHPPSKIAGCPVGRVLWAGLTLLEVPVCLALRVPRLVWAGLLGCARALGLGPKWLGAWEQLGLSAATWTDLFLSCLHSLMLAALLLLLLVWRLYQKAQCCSLGRLPRKALLQNRVVRRSLALLKSLYWWVESTAALTSWHLAYLITWTTCLASHLLQAAFEHTAQLAQAQEAEPQKALGLSSETPPPGPPAPGARPVLPEPGTPGE", "length": 262, "header": "sp|Q2TBQ4-1|TM270_BOVIN Isoform 1 of Transmembrane protein 270 OS=Bos taurus OX=9913 GN=TMEM270 PE=2 SV=1 CANONICAL=Q2TBQ4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 259, "start_aa": "Thr", "end_pos": 259, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr259", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617180", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617180", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ4", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBQ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 262, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBQ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBQ4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 259 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBQ6-1", "uniprot_ac": "Q2TBQ6", "uniprot_id": "HSPB9_BOVIN", "mass": { "chemical_mass": 16784.0, "monoisotopic_mass": 16784.0 }, "refseq": { "ac": "NP_001035667", "name": "heat shock protein beta-9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035667" }, "gene_names": [ { "name": "HSPB9", "type": "recommended", "evidence": [ { "id": "Q2TBQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ] }, { "name": "HSPB9", "type": "synonym", "evidence": [ { "id": "NP_001035667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035667" } ] } ], "protein_names": [ { "name": "Heat shock protein beta-9", "type": "recommended", "evidence": [ { "id": "Q2TBQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6/entry#names_and_taxonomy" } ] }, { "name": "HspB9", "type": "synonym", "evidence": [ { "id": "Q2TBQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6/entry#names_and_taxonomy" } ] }, { "name": "heat shock protein beta-9", "type": "synonym", "evidence": [ { "id": "NP_001035667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035667" } ] }, { "name": "heat shock protein, alpha-crystallin-related, B9", "type": "synonym", "evidence": [ { "id": "NP_001035667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035667" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPB9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6", "locus": { "chromosome": "19", "start_pos": 42258088, "end_pos": 42254230, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024979", "url": "https://www.ensembl.org/id/ENSBTAG00000024979" } ] } } ], "crossref": [ { "id": "Q2TBQ6", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024979", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024979", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614199", "url": "https://www.ncbi.nlm.nih.gov/gene/614199", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614199", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614199", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TAMTCCL", "url": "https://omabrowser.org/oma/group/TAMTCCL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBQ6", "url": "https://www.orthodb.org/?gene=Q2TBQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47896", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47896", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47896:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47896:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035667", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRVGSSLPSGSQSASQCPSVAFTERNQVATLPVQRLTEDAAAVRDNVHTEDGFQMKLYAHGFTPEELLVQVNSGCLVVTGQRQLEGCNPDGTGFRVAQKVHQQMSLPPDLDPAAMTCCLTPSGQLCVRGQCRALPPSEAQTGPASRFRSRGSKKLA", "length": 157, "header": "sp|Q2TBQ6-1|HSPB9_BOVIN Isoform 1 of Heat shock protein beta-9 OS=Bos taurus OX=9913 GN=HSPB9 PE=2 SV=1 CANONICAL=Q2TBQ6-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6/entry#Q2TBQ6-1", "sequence": { "sequence": "MQRVGSSLPSGSQSASQCPSVAFTERNQVATLPVQRLTEDAAAVRDNVHTEDGFQMKLYAHGFTPEELLVQVNSGCLVVTGQRQLEGCNPDGTGFRVAQKVHQQMSLPPDLDPAAMTCCLTPSGQLCVRGQCRALPPSEAQTGPASRFRSRGSKKLA", "length": 157, "header": "sp|Q2TBQ6-1|HSPB9_BOVIN Isoform 1 of Heat shock protein beta-9 OS=Bos taurus OX=9913 GN=HSPB9 PE=2 SV=1 CANONICAL=Q2TBQ6-1" }, "locus": { "chromosome": "19", "start_pos": 42258055, "end_pos": 42257585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034833.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034833.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034717.2", "url": "https://www.ensembl.org/id/ENSBTAP00000034717.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614199", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614199", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LPF7-1", "protein_name": "Heat shock protein family B (small) member 9", "gene_name": "Hspb9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTVGGPFLFAPAPRMWGGGGGSPRALRQQLHSRMQRVGSSFSTGQREPGENRVASRCPSVALSERNQAATLPVRLLKDDLAAAHANGCEEPSFQMKLDAHGFAPEDLVVRIDGQNLMVTGKRQQESNDPSRGRYRLEQSVHRQMQLPMTLDPAAMTCSLTPSGHLWFKGQNKCLPLPEAQTGPQTGQALRFKRGSSKCPNPP", "length": 203 }, "evidence": [ { "id": "Q2TBQ6", "url": "https://omabrowser.org/oma/group/Q2TBQ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S0Q1-1", "protein_name": "Heat shock protein beta-9", "gene_name": "HSPB9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQRVSSGLPNGSQSASRCASVAFTEQNQVATLPVQQLTDDVAAMRDNVHAEDGFQMKMYAHGFTPEELVVQVDGGCLMVTGQRQLEGCSPDGSGFRMAQKVHQQMPLPPGLDPAAMTCCLTPSGQLCVRGQCRALPCPEAQTGPAPRLRSRGSKKGSKLA", "length": 160 }, "evidence": [ { "id": "Q2TBQ6", "url": "https://omabrowser.org/oma/group/Q2TBQ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HLW4-1", "protein_name": "Heat shock protein beta-9", "gene_name": "Hspb9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQRVGSSFSTGQQELGENRVTSRCPSVALSEGYPVAILPVRLLKNDLAVVPSNSRVHANFQMKLDAQGFAPEELMVRVDGQNLTVTGQRQEVSNDGVRGGYRIEQTMHRQMLLPPNLDLAAMTCNLTPSGHLWVLGQKRSLPPPEAQGHGPRFKSRASKHSN", "length": 162 }, "evidence": [ { "id": "Q2TBQ6", "url": "https://omabrowser.org/oma/group/Q2TBQ6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9BQS6-1", "protein_name": "Heat shock protein beta-9", "gene_name": "HSPB9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQRVGNTFSNESRVASRCPSVGLAERNRVATMPVRLLRDSPAAQEDNDHARDGFQMKLDAHGFAPEELVVQVDGQWLMVTGQQQLDVRDPERVSYRMSQKVHRKMLPSNLSPTAMTCCLTPSGQLWVRGQCVALALPEAQTGPSPRLGSLGSKASNLTR", "length": 159 }, "evidence": [ { "id": "Q2TBQ6", "url": "https://omabrowser.org/oma/group/Q2TBQ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAM3-1", "protein_name": "Heat shock protein beta-9", "gene_name": "Hspb9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRVGSSFSTGQREPGENRVASRCPSVALAERNQVATLPVRLLRDEVQGNGCEQPSFQIKVDAQGFAPEDLVVRIDGQNLTVTGQRQHESNDPSRGRYRMEQSVHRQMQLPPTLDPAAMTCSLTPSGHLWLRGQNKCLPPPEAQTGQSQKPRRGGPKSSLQNESVKNP", "length": 168 }, "evidence": [ { "id": "Q2TBQ6", "url": "https://omabrowser.org/oma/group/Q2TBQ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ6", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBQ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 157, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBQ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBQ6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ6" }, { "id": "PRU00285", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00285" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "sHSP", "eco_id": "ECO_0000255", "start_pos": 35, "end_pos": 148, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBR9-1", "uniprot_ac": "Q2TBR9", "uniprot_id": "LLPH_BOVIN", "mass": { "chemical_mass": 15047.0, "monoisotopic_mass": 15047.0 }, "refseq": { "ac": "NP_001033611", "name": "protein LLP homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" }, "gene_names": [ { "name": "LLPH", "type": "recommended", "evidence": [ { "id": "Q2TBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ] }, { "name": "C12orf31", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] }, { "name": "LLPH", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] } ], "protein_names": [ { "name": "Protein LLP homolog", "type": "recommended", "evidence": [ { "id": "Q2TBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9/entry#names_and_taxonomy" } ] }, { "name": "LLP homolog, long-term synaptic facilitation (Aplysia)", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] }, { "name": "Protein LAPS18-like", "type": "synonym", "evidence": [ { "id": "Q2TBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9/entry#names_and_taxonomy" } ] }, { "name": "protein LAPS18-like", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] }, { "name": "protein LLP homolog", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] }, { "name": "uncharacterized protein C12orf31 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611" } ] } ], "function": [ { "annotation": "In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9#function" }, { "database": "UniProtKB", "id": "Q9D945", "url": "https://www.uniprot.org/uniprotkb/Q9D945#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LLPH", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9", "locus": { "chromosome": "5", "start_pos": 47673186, "end_pos": 47669190, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002004", "url": "https://www.ensembl.org/id/ENSBTAG00000002004" } ] } } ], "crossref": [ { "id": "Q2TBR9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002004", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002004", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510518", "url": "https://www.ncbi.nlm.nih.gov/gene/510518", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510518", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510518", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGNYPVW", "url": "https://omabrowser.org/oma/group/YGNYPVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBR9", "url": "https://www.orthodb.org/?gene=Q2TBR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34253:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34253:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBR9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPKELSRLKSILKIDGDVLMKDVQEIATVVEPKHCQEKTQCVVKDETDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKRERKKGKSKVKAMKAAKGLTW", "length": 127, "header": "sp|Q2TBR9-1|LLPH_BOVIN Isoform 1 of Protein LLP homolog OS=Bos taurus OX=9913 GN=LLPH PE=2 SV=1 CANONICAL=Q2TBR9-1" }, "isoforms": [ { "isoform_ac": "Q2TBR9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9/entry#Q2TBR9-1", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPKELSRLKSILKIDGDVLMKDVQEIATVVEPKHCQEKTQCVVKDETDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKRERKKGKSKVKAMKAAKGLTW", "length": 127, "header": "sp|Q2TBR9-1|LLPH_BOVIN Isoform 1 of Protein LLP homolog OS=Bos taurus OX=9913 GN=LLPH PE=2 SV=1 CANONICAL=Q2TBR9-1" }, "locus": { "chromosome": "5", "start_pos": 47672767, "end_pos": 47669197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106944.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106944.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510518", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510518", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B8Z8-1", "protein_name": "Protein LLP homolog", "gene_name": "LLPH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPKELSRLKNILKIGGDVLMKDVQEIATVVEPKRCQEKTQCVEKDETDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKREKKKGKSKAKALKAAKGLAW", "length": 127 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B0BN98-1", "protein_name": "Protein LLP homolog", "gene_name": "Llph", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILKVDGDALMKDVEEIATVVVPKHYQEKMQCDVAVDDEKDDMKMETEIKRNKKTLLDQHGQYPVWMNQRQRKRLKAKREKKRGKSKAKAAKGLAW", "length": 126 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GY09-1", "protein_name": "Protein LLP homolog", "gene_name": "Llph", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILKVDGDTIMKDVEEIATVVVPKQRQEKMQCAAEEEEKDDMKMETEIKRNKKTLLDQNGQYPVWMNQRQRKRLKAKREKKRGKSKAKAAKGLAW", "length": 125 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3B748-1", "protein_name": "Protein LLP homolog", "gene_name": "llph", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKSLRSKWRRKMRAEKRKKVAPKELARLKSALGQGEKGEISMKDVAEIATVVPPEKVKQKPADVDMQEEEADGGKMDLDTKRNKKTMLDEHGRYPVWMNQRQAKKLKAKRVGKNGKPKPKKRLAW", "length": 126 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5ZHK9-1", "protein_name": "Protein LLP homolog", "gene_name": "LLPH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPKELERLKSILRTGADVVMEEVKEVATVLPAKEALEKQDDCKMDVDNKRNKKTLLDQHGQYPIWMNSRQRKKLKAQRLKGKKKSKLPKGLAW", "length": 114 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9BRT6-1", "protein_name": "Protein LLP homolog", "gene_name": "LLPH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPKEASRLKSILKLDGDVLMKDVQEIATVVVPKPKHCQEKMQCEVKDEKDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKREKRKGKSKAKAVKVAKGLAW", "length": 129 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D945-1", "protein_name": "Protein LLP homolog", "gene_name": "Llph", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILRVDGDALMKDVEEIATVVVAKPRQEKMQCEEGRCDGADEEKDDMKMETEIKRNRKTLLDQHGQYPVWMNQRQRKRLKAKREKKRGKSRAKAAKGLAW", "length": 130 }, "evidence": [ { "id": "Q2TBR9", "url": "https://omabrowser.org/oma/group/Q2TBR9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "dendrite extension", "id": "GO:0097484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097484", "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "basal RNA polymerase II transcription machinery binding", "id": "GO:0001099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001099", "evidence": [ { "database": "UniProtKB", "id": "Q2TBR9", "url": "https://www.uniprot.org/uniprotkb/Q2TBR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBR9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBR9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBR9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBS1-1", "uniprot_ac": "Q2TBS1", "uniprot_id": "MTX1_BOVIN", "mass": { "chemical_mass": 35674.0, "monoisotopic_mass": 35674.0 }, "refseq": { "ac": "NP_001035698", "name": "metaxin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035698" }, "gene_names": [ { "name": "MTX1", "type": "recommended", "evidence": [ { "id": "Q2TBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ] }, { "name": "MTX1", "type": "synonym", "evidence": [ { "id": "NP_001035698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035698" } ] } ], "protein_names": [ { "name": "Metaxin-1", "type": "recommended", "evidence": [ { "id": "Q2TBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial outer membrane import complex protein 1", "type": "synonym", "evidence": [ { "id": "Q2TBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1/entry#names_and_taxonomy" } ] }, { "name": "metaxin-1", "type": "synonym", "evidence": [ { "id": "NP_001035698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035698" } ] }, { "name": "mitochondrial outer membrane import complex protein 1", "type": "synonym", "evidence": [ { "id": "NP_001035698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035698" } ] } ], "function": [ { "annotation": "Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTX1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1", "locus": { "chromosome": "3", "start_pos": 15409500, "end_pos": 15414667, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014840", "url": "https://www.ensembl.org/id/ENSBTAG00000014840" } ] } } ], "crossref": [ { "id": "Q2TBS1", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03212", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03212", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "664655", "url": "https://www.ncbi.nlm.nih.gov/gene/664655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:664655", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBS1", "url": "https://www.orthodb.org/?gene=Q2TBS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12289:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12289:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10568", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10568", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035698", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBS1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSHGEVISVPHRIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLKHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE", "length": 317, "header": "sp|Q2TBS1-1|MTX1_BOVIN Isoform 1 of Metaxin-1 OS=Bos taurus OX=9913 GN=MTX1 PE=2 SV=1 CANONICAL=Q2TBS1-1" }, "isoforms": [ { "isoform_ac": "Q2TBS1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1/entry#Q2TBS1-1", "sequence": { "sequence": "MAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSHGEVISVPHRIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLKHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE", "length": 317, "header": "sp|Q2TBS1-1|MTX1_BOVIN Isoform 1 of Metaxin-1 OS=Bos taurus OX=9913 GN=MTX1 PE=2 SV=1 CANONICAL=Q2TBS1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:664655", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:664655", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SAM complex", "id": "GO:0001401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001401", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein insertion into mitochondrial outer membrane", "id": "GO:0045040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045040", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ], "pmid": "" }, { "name": "mitochondrial outer membrane translocase complex assembly", "id": "GO:0070096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070096", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBS1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBS2-1", "uniprot_ac": "Q2TBS2", "uniprot_id": "RM21_BOVIN", "mass": { "chemical_mass": 23183.0, "monoisotopic_mass": 23183.0 }, "refseq": { "ac": "NP_001069982", "name": "large ribosomal subunit protein bL21m precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" }, "gene_names": [ { "name": "MRPL21", "type": "recommended", "evidence": [ { "id": "Q2TBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ] }, { "name": "MRPL21", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein bL21m", "type": "recommended", "evidence": [ { "id": "Q2TBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L21, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" }, { "id": "Q2TBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2/entry#names_and_taxonomy" } ] }, { "name": "L21mt", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" }, { "id": "Q2TBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2/entry#names_and_taxonomy" } ] }, { "name": "MRP-L21", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" }, { "id": "Q2TBS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein bL21m precursor", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" } ] }, { "name": "large ribosomal subunit protein bL21m", "type": "synonym", "evidence": [ { "id": "NP_001069982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL21", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2", "locus": { "chromosome": "29", "start_pos": 46258423, "end_pos": 46268990, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004348", "url": "https://www.ensembl.org/id/ENSBTAG00000004348" } ] } } ], "crossref": [ { "id": "Q2TBS2", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "618609", "url": "https://www.ncbi.nlm.nih.gov/gene/618609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBS2", "url": "https://www.orthodb.org/?gene=Q2TBS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21349", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21349", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21349:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21349:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00829", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00829", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBS2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVAARALPVTFGRLAFACSRSVLRASGPGAASQWSASRRFSSQSASSPQGYVPKTSLSSPPWPEVVLPDPAEEARHHAEVVEKVNELIAGGQYGRLFAVVHFASHQWKVTSEDLILIENKLDIACGERIRMEKVLLVGADDFTLLGRPLLGKDLVRVEATVIEKTESWPRVNMRFQKRKNYKRKRIIVNPQTVLRINTIEIAPRLC", "length": 209, "header": "sp|Q2TBS2-1|RM21_BOVIN Isoform 1 of Large ribosomal subunit protein bL21m OS=Bos taurus OX=9913 GN=MRPL21 PE=1 SV=1 CANONICAL=Q2TBS2-1" }, "isoforms": [ { "isoform_ac": "Q2TBS2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2/entry#Q2TBS2-1", "sequence": { "sequence": "MAAAVAARALPVTFGRLAFACSRSVLRASGPGAASQWSASRRFSSQSASSPQGYVPKTSLSSPPWPEVVLPDPAEEARHHAEVVEKVNELIAGGQYGRLFAVVHFASHQWKVTSEDLILIENKLDIACGERIRMEKVLLVGADDFTLLGRPLLGKDLVRVEATVIEKTESWPRVNMRFQKRKNYKRKRIIVNPQTVLRINTIEIAPRLC", "length": 209, "header": "sp|Q2TBS2-1|RM21_BOVIN Isoform 1 of Large ribosomal subunit protein bL21m OS=Bos taurus OX=9913 GN=MRPL21 PE=1 SV=1 CANONICAL=Q2TBS2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] } ], "pathway": [ { "id": "bta:618609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618609", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS2", "url": "https://www.uniprot.org/uniprotkb/Q2TBS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBS2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 209, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBS2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBS2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2TBT3-1", "uniprot_ac": "Q2TBT3", "uniprot_id": "ECHD2_BOVIN", "mass": { "chemical_mass": 31604.0, "monoisotopic_mass": 31604.0 }, "refseq": { "ac": "NP_001033625", "name": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625" }, "gene_names": [ { "name": "ECHDC2", "type": "recommended", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ] }, { "name": "ECHDC2", "type": "synonym", "evidence": [ { "id": "NP_001033625", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625" } ] } ], "protein_names": [ { "name": "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3/entry#names_and_taxonomy" } ] }, { "name": "enoyl Coenzyme A hydratase domain containing 2", "type": "synonym", "evidence": [ { "id": "NP_001033625", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625" } ] }, { "name": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001033625", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625" } ] }, { "name": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033625", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ECHDC2", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3", "locus": { "chromosome": "3", "start_pos": 93464963, "end_pos": 93434240, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002910", "url": "https://www.ensembl.org/id/ENSBTAG00000002910" } ] } } ], "crossref": [ { "id": "Q2TBT3", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002910", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002910", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06558", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06558", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513795", "url": "https://www.ncbi.nlm.nih.gov/gene/513795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513795", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NMV9", "url": "https://www.orthodb.org/?gene=A0A3Q1NMV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIJ4", "url": "https://www.orthodb.org/?gene=A0A452DIJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N0L3", "url": "https://www.orthodb.org/?gene=G3N0L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBT3", "url": "https://www.orthodb.org/?gene=Q2TBT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11941", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11941", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11941:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11941:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00378", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00378", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16113", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16113", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033625", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20888", "url": "https://www.rhea-db.org/rhea/20888", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NMV9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMV9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIJ4", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0L3", "url": "https://www.uniprot.org/uniprotkb/G3N0L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0L3-1", "url": "https://www.uniprot.org/uniprotkb/G3N0L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBT3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQAPIAVRLSKVAIDRGIEVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE", "length": 296, "header": "sp|Q2TBT3-1|ECHD2_BOVIN Isoform 1 of Enoyl-CoA hydratase domain-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=ECHDC2 PE=2 SV=1 CANONICAL=Q2TBT3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NMV9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3/entry#A0A3Q1NMV9-1", "sequence": { "sequence": "MLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQAPIAVRLSKVAIDRGIEVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE", "length": 265, "header": "tr|A0A3Q1NMV9-1|A0A3Q1NMV9_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=ECHDC2 PE=1 SV=2 CANONICAL=Q2TBT3-1" }, "locus": { "chromosome": "3", "start_pos": 93464387, "end_pos": 93434589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068495.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068495.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073989.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073989.2" } ] } }, { "isoform_ac": "A0A452DIJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3/entry#A0A452DIJ4-1", "sequence": { "sequence": "MSSGFLQAQGAAQGSRPVGGAVCKGLEQSSELSAGGGGGGPSGPFPKWAPMLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQAPIAVRLSKVAIDRGIEVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE", "length": 345, "header": "tr|A0A452DIJ4-1|A0A452DIJ4_BOVIN Computationally mapped isoform of Enoyl-CoA hydratase domain containing 2 OS=Bos taurus OX=9913 GN=ECHDC2 PE=1 SV=2 CANONICAL=Q2TBT3-1" }, "locus": { "chromosome": "3", "start_pos": 93464387, "end_pos": 93434439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003779.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003779.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003779.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003779.7" } ] } }, { "isoform_ac": "G3N0L3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3/entry#G3N0L3-1", "sequence": { "sequence": "MLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQVRLPLSTGGPVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE", "length": 289, "header": "tr|G3N0L3-1|G3N0L3_BOVIN Computationally mapped isoform of Enoyl-CoA hydratase domain containing 2 OS=Bos taurus OX=9913 GN=ECHDC2 PE=3 SV=2 CANONICAL=Q2TBT3-1" }, "locus": { "chromosome": "3", "start_pos": 93464387, "end_pos": 93434589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063029.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063029.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055378.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055378.2" } ] } }, { "isoform_ac": "Q2TBT3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3/entry#Q2TBT3-1", "sequence": { "sequence": "MLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQAPIAVRLSKVAIDRGIEVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE", "length": 296, "header": "sp|Q2TBT3-1|ECHD2_BOVIN Isoform 1 of Enoyl-CoA hydratase domain-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=ECHDC2 PE=2 SV=1 CANONICAL=Q2TBT3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:513795", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513795", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "pmid": "" }, { "name": "enoyl-CoA hydratase activity", "id": "GO:0004300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004300", "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "pmid": "" }, { "name": "3-hydroxyisobutyryl-CoA hydrolase activity", "id": "GO:0003860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003860", "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "Q2TBT3", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20888", "name": "", "equation": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBT3-1", "F1MPK4-1", "Q2HJ73-1" ], "evidence": [ { "id": "20888", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20888" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MPK4", "gene_name": "HIBCH", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ] } ] }, { "uniprot_ac": "Q2HJ73", "gene_name": "HIBCH", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "Q2HJ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ73" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "Q2HJ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ73" } ] } ] }, { "uniprot_ac": "Q2TBT3", "gene_name": "ECHDC2", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBT3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 296, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBT3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBT3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.4", "ec_name": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "3.1.2.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.4" }, { "id": "3.1.2.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBU8-1", "uniprot_ac": "Q2TBU8", "uniprot_id": "MED21_BOVIN", "mass": { "chemical_mass": 15521.0, "monoisotopic_mass": 15521.0 }, "refseq": { "ac": "NP_001033655", "name": "mediator of RNA polymerase II transcription subunit 21", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655" }, "gene_names": [ { "name": "MED21", "type": "recommended", "evidence": [ { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ] }, { "name": "MED21", "type": "synonym", "evidence": [ { "id": "NP_001033655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655" } ] }, { "name": "SURB7", "type": "synonym", "evidence": [ { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 21", "type": "recommended", "evidence": [ { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 21", "type": "synonym", "evidence": [ { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#names_and_taxonomy" } ] }, { "name": "RNA polymerase II holoenzyme component SRB7", "type": "synonym", "evidence": [ { "id": "NP_001033655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655" }, { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#names_and_taxonomy" } ] }, { "name": "RNAPII complex component SRB7", "type": "synonym", "evidence": [ { "id": "NP_001033655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655" }, { "id": "Q2TBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 21", "type": "synonym", "evidence": [ { "id": "NP_001033655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8#function" }, { "database": "UniProtKB", "id": "A0AAA9TM14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM14#function" }, { "database": "UniProtKB", "id": "RU366036", "url": "https://www.uniprot.org/uniprotkb/RU366036#function" }, { "database": "UniProtKB", "id": "ARBA00025687", "url": "https://www.uniprot.org/uniprotkb/ARBA00025687#function" }, { "database": "UniProtKB", "id": "A0A3Q1MRF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF0#function" }, { "database": "UniProtKB", "id": "A0AAF6YND6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YND6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED21", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8", "locus": { "chromosome": "5", "start_pos": 82772595, "end_pos": 82782397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005082", "url": "https://www.ensembl.org/id/ENSBTAG00000005082" } ] } } ], "crossref": [ { "id": "Q2TBU8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005082", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005082", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539496", "url": "https://www.ncbi.nlm.nih.gov/gene/539496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSFPIEA", "url": "https://omabrowser.org/oma/group/DSFPIEA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRF0", "url": "https://www.orthodb.org/?gene=A0A3Q1MRF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2TBU8", "url": "https://www.orthodb.org/?gene=Q2TBU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13381:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13381:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033655", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YND6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YND6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YND6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YND6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBU8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATSLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 144, "header": "sp|Q2TBU8-1|MED21_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus OX=9913 GN=MED21 PE=2 SV=1 CANONICAL=Q2TBU8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRF0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#A0A3Q1MRF0-1", "sequence": { "sequence": "TELSALADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATSLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 135, "header": "tr|A0A3Q1MRF0-1|A0A3Q1MRF0_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus OX=9913 GN=MED21 PE=3 SV=2 CANONICAL=Q2TBU8-1" }, "locus": { "chromosome": "5", "start_pos": 82777758, "end_pos": 82772900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074342.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074342.2" } ] } }, { "isoform_ac": "A0AAA9TM14-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#A0AAA9TM14-1", "sequence": { "sequence": "GWASATSAGVGWRRRLRLEGLRRLRGRAGASGLFACQVEALTAWTVRVHRLALFSRAGFIFLSVLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATSLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 194, "header": "tr|A0AAA9TM14-1|A0AAA9TM14_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus OX=9913 GN=MED21 PE=3 SV=1 CANONICAL=Q2TBU8-1" }, "locus": { "chromosome": "5", "start_pos": 82782198, "end_pos": 82772900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098288.1" } ] } }, { "isoform_ac": "A0AAF6YND6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#A0AAF6YND6-1", "sequence": { "sequence": "ATENLLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATSLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 135, "header": "tr|A0AAF6YND6-1|A0AAF6YND6_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus OX=9913 GN=MED21 PE=3 SV=1 CANONICAL=Q2TBU8-1" }, "locus": { "chromosome": "5", "start_pos": 82774652, "end_pos": 82772900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006696.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006696.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006696.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006696.5" } ] } }, { "isoform_ac": "Q2TBU8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8/entry#Q2TBU8-1", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATSLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 144, "header": "sp|Q2TBU8-1|MED21_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus OX=9913 GN=MED21 PE=2 SV=1 CANONICAL=Q2TBU8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539496", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AA11-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "Med21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSVTHSQSLPDS", "length": 144 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SG80-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "MED21", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTTINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 144 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I0W6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "Med21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSVTRSQSLPDS", "length": 144 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q13503-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "MED21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS", "length": 144 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7ZTI5-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "med21", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCAPPASFSNIQTAINKDQPSNPTEEYAQLFAALIARTAKDVDVLIDSLPSEESTAALQAASLRQLEEENQEAAARLEEVVYRGDALLEKIQTALADIAQSQLRTRSGAPSQQTPPES", "length": 145 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CQ39-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "Med21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSVTHSHSLPDS", "length": 144 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W5P1-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "MED21", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQEDYAQLFAQLIARCAKDIDTLIESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQAQLDMQITLKHDLQ", "length": 142 }, "evidence": [ { "id": "Q2TBU8", "url": "https://omabrowser.org/oma/group/Q2TBU8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q2TBU8", "url": "https://www.uniprot.org/uniprotkb/Q2TBU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBU8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBU8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBU8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBX7-1", "uniprot_ac": "Q2TBX7", "uniprot_id": "CCD86_BOVIN", "mass": { "chemical_mass": 39874.0, "monoisotopic_mass": 39874.0 }, "refseq": { "ac": "NP_001033663", "name": "coiled-coil domain-containing protein 86", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033663" }, "gene_names": [ { "name": "CCDC86", "type": "recommended", "evidence": [ { "id": "Q2TBX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ] }, { "name": "CCDC86", "type": "synonym", "evidence": [ { "id": "NP_001033663", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033663" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 86", "type": "recommended", "evidence": [ { "id": "Q2TBX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 86", "type": "synonym", "evidence": [ { "id": "NP_001033663", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033663" } ] } ], "function": [ { "annotation": "Required for proper chromosome segregation during mitosis and error-free mitotic progression.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7#function" }, { "database": "UniProtKB", "id": "Q9H6F5", "url": "https://www.uniprot.org/uniprotkb/Q9H6F5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC86", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7", "locus": { "chromosome": "29", "start_pos": 37178874, "end_pos": 37170153, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014215", "url": "https://www.ensembl.org/id/ENSBTAG00000014215" } ] } } ], "crossref": [ { "id": "Q2TBX7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "540913", "url": "https://www.ncbi.nlm.nih.gov/gene/540913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBX7", "url": "https://www.orthodb.org/?gene=Q2TBX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13557", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13557", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13557:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13557:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001033663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033663", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBX7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTPLRRSRRLEGLKPESPENPTSVLRVRRVLVEFESNPKETGEPRSPPGLGSPSRQPETSPGSPSLPNGPALGSPRKQPELDSGSPEGHRDPGLNFPQNQPESSPESHLLQPKPSEESPKFSQNQGEADSELPKSKEEPTPGCPRHQLQQDSGSLEPFPGQKAPGPEPSKPLQELTPRSPGSPRDQHEPSKPPAAGEPAREGPAPKKREGSSAQAPASKKPKEEIPVIPKGKPKSGRVWKDRSKKRFSQMVQDKPLRTSWQRKMKDRQERKLAKDFARHLEEEKERRRQEKKKRRAENLRRRLENERKAEIVQVIRNPAKLKRAKKKQLRSIEKRDTLAQLQKQPPQRPATKV", "length": 354, "header": "sp|Q2TBX7-1|CCD86_BOVIN Isoform 1 of Coiled-coil domain-containing protein 86 OS=Bos taurus OX=9913 GN=CCDC86 PE=2 SV=1 CANONICAL=Q2TBX7-1" }, "isoforms": [ { "isoform_ac": "Q2TBX7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7/entry#Q2TBX7-1", "sequence": { "sequence": "MDTPLRRSRRLEGLKPESPENPTSVLRVRRVLVEFESNPKETGEPRSPPGLGSPSRQPETSPGSPSLPNGPALGSPRKQPELDSGSPEGHRDPGLNFPQNQPESSPESHLLQPKPSEESPKFSQNQGEADSELPKSKEEPTPGCPRHQLQQDSGSLEPFPGQKAPGPEPSKPLQELTPRSPGSPRDQHEPSKPPAAGEPAREGPAPKKREGSSAQAPASKKPKEEIPVIPKGKPKSGRVWKDRSKKRFSQMVQDKPLRTSWQRKMKDRQERKLAKDFARHLEEEKERRRQEKKKRRAENLRRRLENERKAEIVQVIRNPAKLKRAKKKQLRSIEKRDTLAQLQKQPPQRPATKV", "length": 354, "header": "sp|Q2TBX7-1|CCD86_BOVIN Isoform 1 of Coiled-coil domain-containing protein 86 OS=Bos taurus OX=9913 GN=CCDC86 PE=2 SV=1 CANONICAL=Q2TBX7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 141, "start_aa": "Thr", "end_pos": 141, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr141", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser105" }, { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser108" }, { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser123" }, { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser183" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser18" }, { "start_pos": 212, "end_pos": 212, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser212" }, { "start_pos": 213, "end_pos": 213, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser213" }, { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser24" }, { "start_pos": 47, "end_pos": 47, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser47" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser53" }, { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Thr60" }, { "start_pos": 61, "end_pos": 61, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser61" }, { "start_pos": 64, "end_pos": 64, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser64" }, { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser75" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "site_lbl": "Ser86" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540913", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "pmid": "" }, { "name": "mitotic nuclear division", "id": "GO:0140014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140014", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX7", "url": "https://www.uniprot.org/uniprotkb/Q2TBX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 141 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 18, 24, 47, 53, 60, 61, 64, 75, 86, 105, 108, 123, 183, 212, 213 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 15 }, { "field": "total_sites", "count": 15 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDD0-1", "uniprot_ac": "Q2YDD0", "uniprot_id": "HSP7E_BOVIN", "mass": { "chemical_mass": 54930.0, "monoisotopic_mass": 54930.0 }, "refseq": { "ac": "NP_001039853", "name": "heat shock 70 kDa protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039853" }, "gene_names": [ { "name": "HSPA14", "type": "recommended", "evidence": [ { "id": "Q2YDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ] }, { "name": "HSPA14", "type": "synonym", "evidence": [ { "id": "NP_001039853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039853" } ] } ], "protein_names": [ { "name": "Heat shock 70 kDa protein 14", "type": "recommended", "evidence": [ { "id": "Q2YDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0/entry#names_and_taxonomy" } ] }, { "name": "heat shock 70 kDa protein 14", "type": "synonym", "evidence": [ { "id": "NP_001039853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039853" } ] }, { "name": "heat shock 70kDa protein 14", "type": "synonym", "evidence": [ { "id": "NP_001039853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039853" } ] } ], "function": [ { "annotation": "Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPA14", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0", "locus": { "chromosome": "13", "start_pos": 29517243, "end_pos": 29492741, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016451", "url": "https://www.ensembl.org/id/ENSBTAG00000016451" } ] } } ], "crossref": [ { "id": "Q2YDD0", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016451", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016451", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10238", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10238", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534751", "url": "https://www.ncbi.nlm.nih.gov/gene/534751", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534751", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534751", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQVLMDH", "url": "https://omabrowser.org/oma/group/DQVLMDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDD0", "url": "https://www.orthodb.org/?gene=Q2YDD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q2YDD0", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q2YDD0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-BTA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDD0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSKNEEVVGLAAKQSRIRNISNTVMKVKQILGRSSDDPQSRKYITESKCLVIEKNGKLLYEIDTGEEKKFVSPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKSALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSISVMEVNSGIYRVLSTNTDNNIGGTHFTETLAQYLASEFQRSFRHDVRGNARAMMKLMNGADTAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIREVLEQSGFTADDINKVVLCGGSSRIPRLQQMIRDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKESLSVEDALQIECSAKDILVKGVDESGANSFKVLFPSGTPLPARRQHTLQAPGSISSVCLELYESEGKNSAKVENKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAITIEVAS", "length": 509, "header": "sp|Q2YDD0-1|HSP7E_BOVIN Isoform 1 of Heat shock 70 kDa protein 14 OS=Bos taurus OX=9913 GN=HSPA14 PE=2 SV=1 CANONICAL=Q2YDD0-1" }, "isoforms": [ { "isoform_ac": "Q2YDD0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0/entry#Q2YDD0-1", "sequence": { "sequence": "MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSKNEEVVGLAAKQSRIRNISNTVMKVKQILGRSSDDPQSRKYITESKCLVIEKNGKLLYEIDTGEEKKFVSPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKSALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSISVMEVNSGIYRVLSTNTDNNIGGTHFTETLAQYLASEFQRSFRHDVRGNARAMMKLMNGADTAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIREVLEQSGFTADDINKVVLCGGSSRIPRLQQMIRDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKESLSVEDALQIECSAKDILVKGVDESGANSFKVLFPSGTPLPARRQHTLQAPGSISSVCLELYESEGKNSAKVENKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAITIEVAS", "length": 509, "header": "sp|Q2YDD0-1|HSP7E_BOVIN Isoform 1 of Heat shock 70 kDa protein 14 OS=Bos taurus OX=9913 GN=HSPA14 PE=2 SV=1 CANONICAL=Q2YDD0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534751", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534751", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R1Z5-1", "protein_name": "Heat shock 70 kDa protein 14", "gene_name": "HSPA14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAVVAYTENEEVVGLAAKQSRIRNISNTVMKVKQILGRSSDDPQAQKYISESKCLVIEKNGKLRYEIDTGEEMKFVNPEDVARLIFSKMKETAHSVLGPDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSISVMQVNSGIYRVLSTNTDNNIGGTHFTETLAQYLASEFQRSFKHDVRGNARAMMKLMNSADTAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLEQSGFTADDINKVVLCGGSSRIPRLQQMIKELFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLKIECSAKDILVKGVDESGANSFRVLFPSGTPLPARRQHMLQAPGSISSVCLELYESDGKNSAKEENKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAITIEVAS", "length": 509 }, "evidence": [ { "id": "Q2YDD0", "url": "https://omabrowser.org/oma/group/Q2YDD0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q99M31-1", "protein_name": "Heat shock 70 kDa protein 14", "gene_name": "Hspa14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSEREQVVGLAAKQSRIRHVSSTVVKVKQILGRSSADPQAQKYISESKCLVIEKNGKLRYEIDTGEETKLVNPEDVARLIFSKMKETAHSVLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDHPTGKSNVLVFKLGGTSLSLSVMEVNSGMYRVLSTNTSDNIGGAHFTDTLAQYLASEFQRLFKHDVRGNARAMMKLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCTEAIRELLRQTGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDDSVMIECSAKDILVKGVDESGADRFTVLFPSGTPLPARRQHTLQAPGRVSSVCLELYESEGKNSAKEEAKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQDTGKCEAITVEVAS", "length": 509 }, "evidence": [ { "id": "Q2YDD0", "url": "https://omabrowser.org/oma/group/Q2YDD0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "heat shock protein binding", "id": "GO:0031072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD0", "url": "https://www.uniprot.org/uniprotkb/Q2YDD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDD0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 509, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDD0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDD0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 294, "end_pos": 296 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDD6-1", "uniprot_ac": "Q2YDD6", "uniprot_id": "SNG4_BOVIN", "mass": { "chemical_mass": 25373.0, "monoisotopic_mass": 25373.0 }, "refseq": { "ac": "NP_001039901", "name": "synaptogyrin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039901" }, "gene_names": [ { "name": "SYNGR4", "type": "recommended", "evidence": [ { "id": "Q2YDD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6" } ] }, { "name": "SYNGR4", "type": "synonym", "evidence": [ { "id": "NP_001039901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039901" } ] } ], "protein_names": [ { "name": "Synaptogyrin-4", "type": "recommended", "evidence": [ { "id": "Q2YDD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6/entry#names_and_taxonomy" } ] }, { "name": "synaptogyrin-4", "type": "synonym", "evidence": [ { "id": "NP_001039901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039901" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDD6", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNGR4", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6", "locus": { "chromosome": "18", "start_pos": 55075090, "end_pos": 55064443, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008546", "url": "https://www.ensembl.org/id/ENSBTAG00000008546" } ] } } ], "crossref": [ { "id": "Q2YDD6", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "538683", "url": "https://www.ncbi.nlm.nih.gov/gene/538683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538683", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538683", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDD6", "url": "https://www.orthodb.org/?gene=Q2YDD6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10838", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10838", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10838:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10838:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039901", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDD6", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDD6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHIPESLQDLADSEAVQFLKRPKAITRIFAGVFSLIVFSSLLTDGYQNKTDNSELHCVLNSNSTACSIAVGAGLLAFLSSLAFLALDAHEVRLASTRFKTAFQLLDLILAVIWAGVWAVGFCFLANQWHRSPPRYFLLGSNSAKAAITFSFFSILVWIFQAYLAFQELRNDAPVPYKRSLDEGGVVLTSLSPPSAASPVNTPTTGPHGPSYASSSLSPYLSTPKAPRLAMMPDN", "length": 234, "header": "sp|Q2YDD6-1|SNG4_BOVIN Isoform 1 of Synaptogyrin-4 OS=Bos taurus OX=9913 GN=SYNGR4 PE=2 SV=1 CANONICAL=Q2YDD6-1" }, "isoforms": [ { "isoform_ac": "Q2YDD6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6/entry#Q2YDD6-1", "sequence": { "sequence": "MHIPESLQDLADSEAVQFLKRPKAITRIFAGVFSLIVFSSLLTDGYQNKTDNSELHCVLNSNSTACSIAVGAGLLAFLSSLAFLALDAHEVRLASTRFKTAFQLLDLILAVIWAGVWAVGFCFLANQWHRSPPRYFLLGSNSAKAAITFSFFSILVWIFQAYLAFQELRNDAPVPYKRSLDEGGVVLTSLSPPSAASPVNTPTTGPHGPSYASSSLSPYLSTPKAPRLAMMPDN", "length": 234, "header": "sp|Q2YDD6-1|SNG4_BOVIN Isoform 1 of Synaptogyrin-4 OS=Bos taurus OX=9913 GN=SYNGR4 PE=2 SV=1 CANONICAL=Q2YDD6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538683", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538683", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD6", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD6", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDD6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDD6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDD6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD6" }, { "id": "PRU00581", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00581" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MARVEL", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 169, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDE2-1", "uniprot_ac": "Q2YDE2", "uniprot_id": "SPT46_BOVIN", "mass": { "chemical_mass": 27521.0, "monoisotopic_mass": 27521.0 }, "refseq": { "ac": "NP_001039925", "name": "spermatogenesis-associated protein 46", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" }, "gene_names": [ { "name": "SPATA46", "type": "recommended", "evidence": [ { "id": "Q2YDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ] }, { "name": "C1orf111", "type": "synonym", "evidence": [ { "id": "NP_001039925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" } ] }, { "name": "C3H1orf111", "type": "synonym", "evidence": [ { "id": "NP_001039925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" } ] }, { "name": "SPATA46", "type": "synonym", "evidence": [ { "id": "NP_001039925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" } ] } ], "protein_names": [ { "name": "Spermatogenesis-associated protein 46", "type": "recommended", "evidence": [ { "id": "Q2YDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 46", "type": "synonym", "evidence": [ { "id": "NP_001039925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" } ] }, { "name": "uncharacterized protein C1orf111 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925" } ] } ], "function": [ { "annotation": "Plays a role in spermiogenesis and fertilization.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2#function" }, { "database": "UniProtKB", "id": "Q4FZF2", "url": "https://www.uniprot.org/uniprotkb/Q4FZF2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA46", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2", "locus": { "chromosome": "3", "start_pos": 7119975, "end_pos": 7112701, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010174", "url": "https://www.ensembl.org/id/ENSBTAG00000010174" } ] } } ], "crossref": [ { "id": "Q2YDE2", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010174", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010174", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539685", "url": "https://www.ncbi.nlm.nih.gov/gene/539685", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539685", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539685", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYQSITV", "url": "https://omabrowser.org/oma/group/QYQSITV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDE2", "url": "https://www.orthodb.org/?gene=Q2YDE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17734", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17734", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPDCILGDAPNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRPGPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYKEQKARPGDRLSLGSGQAFR", "length": 247, "header": "sp|Q2YDE2-1|SPT46_BOVIN Isoform 1 of Spermatogenesis-associated protein 46 OS=Bos taurus OX=9913 GN=SPATA46 PE=2 SV=1 CANONICAL=Q2YDE2-1" }, "isoforms": [ { "isoform_ac": "Q2YDE2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2/entry#Q2YDE2-1", "sequence": { "sequence": "MENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPDCILGDAPNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRPGPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYKEQKARPGDRLSLGSGQAFR", "length": 247, "header": "sp|Q2YDE2-1|SPT46_BOVIN Isoform 1 of Spermatogenesis-associated protein 46 OS=Bos taurus OX=9913 GN=SPATA46 PE=2 SV=1 CANONICAL=Q2YDE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539685", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539685", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZI03-1", "protein_name": "Spermatosis associated 46", "gene_name": "SPATA46", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENFSLLSISGPRISSSVLSTFPDIMSSRATSLPDCILGDPQNGEQLRRNCTIYRPWFSPYSYFVCTDKESHLETYSFPEVQRDEGRGDNCLLEDMAESICSSSSSPENVCLREATKKSRHGLNSMDYITSQDILIASRWHPVQQSGYKCAACCRMYPTLHSLKSHIKGGFKEGFSCKVYYRKLKTLWGKEQKARPGDRLSSGSCQAFK", "length": 209 }, "evidence": [ { "id": "Q2YDE2", "url": "https://omabrowser.org/oma/group/Q2YDE2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZEQ6-1", "protein_name": "Spermatogenesis associated 46", "gene_name": "Spata46", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MENFSLLSTSRPRISSSALSAFPDIMSSLATSLPDLGDTQNGEQLRRNCTIYRPWFSPYSYFVCTDKESHLEAYGFPEVDREEGRGDNCLLEDVAESVCSSSSSQENTYPREANKKSKHGLDSITSQDILMASKWHPAQQNGYKCAACCRMYPTLHSLKSHIKGGFKEGFSCKVYYRKLKTLWGKEQKARTGDRISLGSCQAFK", "length": 204 }, "evidence": [ { "id": "Q2YDE2", "url": "https://omabrowser.org/oma/group/Q2YDE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4FZF2-1", "protein_name": "Spermatogenesis-associated protein 46", "gene_name": "Spata46", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDNYSLLSTPRPRISSSALSAFPDIMSSLATSLPDLGDTQNGEQLRRNCTIYRPWFSPYSYFVCTDKESHLEAYGFPEVDREEGRGDNCLLEDVAESVCSSSSSQENTYPREANRKSKHGLDSITSQDILMASKWHPAQQNGYKCASCCRMYPTLHSLKSHIKGGFKEGFSCKVYYRKLKTLWGKEQKARTGDRISLGSCQAFK", "length": 204 }, "evidence": [ { "id": "Q2YDE2", "url": "https://omabrowser.org/oma/group/Q2YDE2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T0L3-1", "protein_name": "Spermatogenesis-associated protein 46", "gene_name": "SPATA46", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSIIVRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYFVCADKESQLEAYDFPEVQQDEGKWDNCLSEDMAENICSSSSSPENTCPREATKKSRHGLDSITSQDILMASRWHPAQQNGYKCVACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSKEQKARLGDRLSSGSCQAFNSPAEHLRQIGGEAYLCL", "length": 261 }, "evidence": [ { "id": "Q2YDE2", "url": "https://omabrowser.org/oma/group/Q2YDE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDE5-1", "uniprot_ac": "Q2YDE5", "uniprot_id": "CC196_BOVIN", "mass": { "chemical_mass": 22923.0, "monoisotopic_mass": 22923.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC196", "type": "recommended", "evidence": [ { "id": "Q2YDE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5" } ] } ], "protein_names": [ { "name": "Putative coiled-coil domain-containing protein 196", "type": "recommended", "evidence": [ { "id": "Q2YDE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDE5", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC196", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5", "locus": { "chromosome": "10", "start_pos": 78561254, "end_pos": 78535568, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014234", "url": "https://www.ensembl.org/id/ENSBTAG00000014234" } ] } } ], "crossref": [ { "id": "Q2YDE5", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014234", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014234", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR038857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ89", "url": "https://www.orthodb.org/?gene=A0A452DJ89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q2YDE5", "url": "https://www.orthodb.org/?gene=Q2YDE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37863", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37863", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37863:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37863:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ89", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ89-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE5", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSASNSPESYLSSKTRSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKAPKTPSSSRKTKNELETLCAEKGKEIRKRLFLPPGKETEENGMGQVSGTSQHHSE", "length": 198, "header": "sp|Q2YDE5-1|CC196_BOVIN Isoform 1 of Putative coiled-coil domain-containing protein 196 OS=Bos taurus OX=9913 GN=CCDC196 PE=5 SV=1 CANONICAL=Q2YDE5-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ89-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5/entry#A0A452DJ89-1", "sequence": { "sequence": "MTSASNSPESYLSSKTSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKAPKTPSSSRKTKNELETLCAEKGKEIRKEKKQRKMEWVRYQEQANIIQNDFNGKVIELRIETLKNYQKANDLKLSLYIQQNFEPKQEFLNLPRSQGTLDTTTMSRATTCKNESNERILGSKTSTEQQRAKGSQFDDARGRLFFLRSRPDEVLKD", "length": 296, "header": "tr|A0A452DJ89-1|A0A452DJ89_BOVIN Computationally mapped isoform of Coiled-coil domain containing 196 OS=Bos taurus OX=9913 GN=CCDC196 PE=4 SV=2 CANONICAL=Q2YDE5-1" }, "locus": { "chromosome": "10", "start_pos": 78550954, "end_pos": 78537746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043345.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043345.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040920.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040920.3" } ] } }, { "isoform_ac": "A0AAA9SPZ6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5/entry#A0AAA9SPZ6-1", "sequence": { "sequence": "MTSASNSPESYLSSKTRSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKEKKQRKMEWVRYQEQANIIQNDFNGKVIELRIETLKNYQKANDLKLSLYIQQNFEPKQEFLNLPRSQGTLDTTTMSRATTCKNESNERILGSKTSTEQQRAKGSQFDDARGRLFFLRSRPDEVLKD", "length": 269, "header": "tr|A0AAA9SPZ6-1|A0AAA9SPZ6_BOVIN Computationally mapped isoform of Coiled-coil domain containing 196 OS=Bos taurus OX=9913 GN=CCDC196 PE=4 SV=2 CANONICAL=Q2YDE5-1" }, "locus": { "chromosome": "10", "start_pos": 78550954, "end_pos": 78537746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127596.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127596.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088381.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088381.2" } ] } }, { "isoform_ac": "A0AAA9SR90-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5/entry#A0AAA9SR90-1", "sequence": { "sequence": "MTSASNSPESYLSSKTRSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKAPKTPSSSRKTKNELETLCAEKGKEIRKEKKQRKMEWVRYQEQANIIQNDFNGKVIELRIETLKNYQKANDLKLSLYIQQNFEPKQEFLNLPRSQGTLDTTTMSRATTCKNESNESHPPLILVLPVVVQLMLTLWE", "length": 279, "header": "tr|A0AAA9SR90-1|A0AAA9SR90_BOVIN Computationally mapped isoform of Coiled-coil domain containing 196 OS=Bos taurus OX=9913 GN=CCDC196 PE=4 SV=1 CANONICAL=Q2YDE5-1" }, "locus": { "chromosome": "10", "start_pos": 78560250, "end_pos": 78537746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108701.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108701.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087864.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087864.1" } ] } }, { "isoform_ac": "Q2YDE5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE5/entry#Q2YDE5-1", "sequence": { "sequence": "MTSASNSPESYLSSKTRSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKAPKTPSSSRKTKNELETLCAEKGKEIRKRLFLPPGKETEENGMGQVSGTSQHHSE", "length": 198, "header": "sp|Q2YDE5-1|CC196_BOVIN Isoform 1 of Putative coiled-coil domain-containing protein 196 OS=Bos taurus OX=9913 GN=CCDC196 PE=5 SV=1 CANONICAL=Q2YDE5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDE5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDE5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDE5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 135, "end_pos": 137 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDE8-1", "uniprot_ac": "Q2YDE8", "uniprot_id": "GAR2_BOVIN", "mass": { "chemical_mass": 44289.0, "monoisotopic_mass": 44289.0 }, "refseq": { "ac": "NP_001040090", "name": "Golgi-associated RAB2 interactor protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" }, "gene_names": [ { "name": "GARIN2", "type": "recommended", "evidence": [ { "id": "Q2YDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8" } ] }, { "name": "C10H14orf54", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "C14orf54", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "FAM71D", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" }, { "id": "Q2YDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8" } ] }, { "name": "GARIN2", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] } ], "protein_names": [ { "name": "Golgi-associated RAB2 interactor protein 2", "type": "recommended", "evidence": [ { "id": "Q2YDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8/entry#names_and_taxonomy" } ] }, { "name": "Golgi associated RAB2 interactor protein 2", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "Golgi-associated RAB2 interactor protein 2", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "family with sequence similarity 71 member D", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "family with sequence similarity 71, member D ortholog", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] }, { "name": "protein FAM71D", "type": "synonym", "evidence": [ { "id": "NP_001040090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090" } ] } ], "function": [ { "annotation": "Seems to play a role in sperm motility.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE8", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8#function" }, { "database": "UniProtKB", "id": "D3YV92", "url": "https://www.uniprot.org/uniprotkb/D3YV92#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDE8", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GARIN2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8", "locus": { "chromosome": "10", "start_pos": 79149489, "end_pos": 79106952, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010239", "url": "https://www.ensembl.org/id/ENSBTAG00000010239" } ] } } ], "crossref": [ { "id": "Q2YDE8", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "618905", "url": "https://www.ncbi.nlm.nih.gov/gene/618905", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618905", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618905", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDE8", "url": "https://www.orthodb.org/?gene=Q2YDE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040090", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDE8", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE8-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDDTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSDKCKLLN", "length": 397, "header": "sp|Q2YDE8-1|GAR2_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=2 SV=1 CANONICAL=Q2YDE8-1" }, "isoforms": [ { "isoform_ac": "Q2YDE8-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8/entry#Q2YDE8-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDDTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSDKCKLLN", "length": 397, "header": "sp|Q2YDE8-1|GAR2_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=2 SV=1 CANONICAL=Q2YDE8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 71, "start_aa": "Thr", "end_pos": 71, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:618905", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618905", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE8", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE8", "url": "https://www.uniprot.org/uniprotkb/Q2YDE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 397, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDE8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 71 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDE9-1", "uniprot_ac": "Q2YDE9", "uniprot_id": "TES_BOVIN", "mass": { "chemical_mass": 48049.0, "monoisotopic_mass": 48049.0 }, "refseq": { "ac": "NP_001039855", "name": "testin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039855" }, "gene_names": [ { "name": "TES", "type": "recommended", "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ] }, { "name": "TES", "type": "synonym", "evidence": [ { "id": "NP_001039855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039855" } ] } ], "protein_names": [ { "name": "Testin", "type": "recommended", "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9/entry#names_and_taxonomy" } ] }, { "name": "testin", "type": "synonym", "evidence": [ { "id": "NP_001039855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039855" } ] }, { "name": "testis derived transcript (3 LIM domains)", "type": "synonym", "evidence": [ { "id": "NP_001039855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039855" } ] } ], "function": [ { "annotation": "Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TES", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9", "locus": { "chromosome": "4", "start_pos": 52169927, "end_pos": 52224938, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021204", "url": "https://www.ensembl.org/id/ENSBTAG00000021204" } ] } } ], "crossref": [ { "id": "Q2YDE9", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021204", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021204", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09413", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09413", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09829", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09829", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534965", "url": "https://www.ncbi.nlm.nih.gov/gene/534965", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534965", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534965", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHMGPHS", "url": "https://omabrowser.org/oma/group/PHMGPHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDE9", "url": "https://www.orthodb.org/?gene=Q2YDE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24211", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24211", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24211:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24211:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039855", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLEAKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKNEALGVGDVKLPRDMNTQGPNKMYIPGGDRSTTTAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGEIYVMVNDKPVCKPCYVKNHAEVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS", "length": 421, "header": "sp|Q2YDE9-1|TES_BOVIN Isoform 1 of Testin OS=Bos taurus OX=9913 GN=TES PE=2 SV=1 CANONICAL=Q2YDE9-1" }, "isoforms": [ { "isoform_ac": "Q2YDE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9/entry#Q2YDE9-1", "sequence": { "sequence": "MDLEAKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKNEALGVGDVKLPRDMNTQGPNKMYIPGGDRSTTTAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGEIYVMVNDKPVCKPCYVKNHAEVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS", "length": 421, "header": "sp|Q2YDE9-1|TES_BOVIN Isoform 1 of Testin OS=Bos taurus OX=9913 GN=TES PE=2 SV=1 CANONICAL=Q2YDE9-1" }, "locus": { "chromosome": "4", "start_pos": 52224773, "end_pos": 52170004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031716.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031716.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031665.4", "url": "https://www.ensembl.org/id/ENSBTAP00000031665.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Comparative analyses of multi-species sequences from targeted genomic regions.", "journal": "Nature", "date": "2003", "authors": "Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin SQ, Maduro VV, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho SL, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang LH, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler D, Green P, Miller W, Green ED", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "reference": [ { "type": "PubMed", "id": "12917688", "url": "https://glygen.org/publication/PubMed/12917688" } ] } ], "pathway": [ { "id": "bta:534965", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534965", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P47226-1", "protein_name": "Testin", "gene_name": "Tes", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSATHPTRLGTRTKESNACASQGLVRKPPWANEGEGFELHFWRKICRNCNVVKKSMTVLLSNEEDRKVGRLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKSEALGVGDVKFPSEMNAQGDKVHNCGNRHAPAAVASKDKSAESKKTQYSCYCCKHTTNEGEPAIYAERAGYDKLWHPACFICSTCGELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDHILAGKIYVMVTDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKRMMS", "length": 423 }, "evidence": [ { "id": "Q2YDE9", "url": "https://omabrowser.org/oma/group/Q2YDE9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q2LAP6-1", "protein_name": "Testin", "gene_name": "Tes", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLETKMKKMGLGHEQGFGAPCLKCKENCEGFELHFWRKICRNCKCGQEEHDVLLSTEEDRKVGRLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKSEALGVGDVKLPSEMNAQGDKVHNPAGDRNTPAAVGSKDKSAEAKKTQYSCYCCKNTMREGDPAIYAERAGYDKLWHPACFICSTCGELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGKIYVMVRDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS", "length": 419 }, "evidence": [ { "id": "Q2YDE9", "url": "https://omabrowser.org/oma/group/Q2YDE9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2QLE3-1", "protein_name": "Testin", "gene_name": "TES", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLEAKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNISINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKSEALGVGDVKLPREMNAQGPNRMCIPGGDRSTTSAVGAMEDKSAEHKTTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNDKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS", "length": 421 }, "evidence": [ { "id": "Q2YDE9", "url": "https://omabrowser.org/oma/group/Q2YDE9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE9", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDE9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 421, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDE9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDE9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 1", "eco_id": "ECO_0000255", "start_pos": 234, "end_pos": 297, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 2", "eco_id": "ECO_0000255", "start_pos": 299, "end_pos": 359, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 3", "eco_id": "ECO_0000255", "start_pos": 362, "end_pos": 421, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE9" }, { "id": "PRU00636", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00636" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PET", "eco_id": "ECO_0000255", "start_pos": 92, "end_pos": 199, "start_aa": "Met", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 379, "end_pos": 381 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2YDF7-1", "uniprot_ac": "Q2YDF7", "uniprot_id": "JSPR1_BOVIN", "mass": { "chemical_mass": 36954.0, "monoisotopic_mass": 36954.0 }, "refseq": { "ac": "NP_001039496", "name": "junctional sarcoplasmic reticulum protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039496" }, "gene_names": [ { "name": "JSRP1", "type": "recommended", "evidence": [ { "id": "Q2YDF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7" } ] }, { "name": "JSRP1", "type": "synonym", "evidence": [ { "id": "NP_001039496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039496" } ] } ], "protein_names": [ { "name": "Junctional sarcoplasmic reticulum protein 1", "type": "recommended", "evidence": [ { "id": "Q2YDF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7/entry#names_and_taxonomy" } ] }, { "name": "junctional sarcoplasmic reticulum protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039496" } ] } ], "function": [ { "annotation": "Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JSRP1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7", "locus": { "chromosome": "7", "start_pos": 21404532, "end_pos": 21408414, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014956", "url": "https://www.ensembl.org/id/ENSBTAG00000014956" } ] } } ], "crossref": [ { "id": "Q2YDF7", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "509378", "url": "https://www.ncbi.nlm.nih.gov/gene/509378", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509378", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509378", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDF7", "url": "https://www.orthodb.org/?gene=Q2YDF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22397:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22397:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039496", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDF7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRAMEELDGGLGSCQVDEDLSALADPCPSRPQEDSVRATSRLADSSSRSHDSQERVTEGSPTGSVDTKPKKMEKEPVSKVTSGAGKEKLKAGATPRSPARKKAQTASPTQPPPPPALSDELPWGDLTLNKCLVLASLVALLGSAFQLCREAVARDVEAPAPVPESWASSSSSPKGPASTLPKPEAWAPSVRQPEPPSKLEERVQIPRSEEAAEKDEWESEEAADGEHVPLAGRGPKEKLKKEKPRKERPGKEKPQKEERPRKEKPRKEEKPRGAREPQGALPRRWEAREGGHRPWGRDSGAPEDRKRQAWVSLRRPDEEDRPLGRQKRRAGKGRD", "length": 337, "header": "sp|Q2YDF7-1|JSPR1_BOVIN Isoform 1 of Junctional sarcoplasmic reticulum protein 1 OS=Bos taurus OX=9913 GN=JSRP1 PE=2 SV=1 CANONICAL=Q2YDF7-1" }, "isoforms": [ { "isoform_ac": "Q2YDF7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7/entry#Q2YDF7-1", "sequence": { "sequence": "MATRAMEELDGGLGSCQVDEDLSALADPCPSRPQEDSVRATSRLADSSSRSHDSQERVTEGSPTGSVDTKPKKMEKEPVSKVTSGAGKEKLKAGATPRSPARKKAQTASPTQPPPPPALSDELPWGDLTLNKCLVLASLVALLGSAFQLCREAVARDVEAPAPVPESWASSSSSPKGPASTLPKPEAWAPSVRQPEPPSKLEERVQIPRSEEAAEKDEWESEEAADGEHVPLAGRGPKEKLKKEKPRKERPGKEKPQKEERPRKEKPRKEEKPRGAREPQGALPRRWEAREGGHRPWGRDSGAPEDRKRQAWVSLRRPDEEDRPLGRQKRRAGKGRD", "length": 337, "header": "sp|Q2YDF7-1|JSPR1_BOVIN Isoform 1 of Junctional sarcoplasmic reticulum protein 1 OS=Bos taurus OX=9913 GN=JSRP1 PE=2 SV=1 CANONICAL=Q2YDF7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509378", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509378", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "skeletal muscle contraction", "id": "GO:0003009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003009", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sarcoplasmic reticulum", "id": "GO:0016529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum membrane", "id": "GO:0033017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033017", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF7", "url": "https://www.uniprot.org/uniprotkb/Q2YDF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 337, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDG1-1", "uniprot_ac": "Q2YDG1", "uniprot_id": "TM247_BOVIN", "mass": { "chemical_mass": 24443.0, "monoisotopic_mass": 24443.0 }, "refseq": { "ac": "NP_001070537", "name": "transmembrane protein 247", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070537" }, "gene_names": [ { "name": "TMEM247", "type": "recommended", "evidence": [ { "id": "Q2YDG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1" } ] }, { "name": "TMEM247", "type": "synonym", "evidence": [ { "id": "NP_001070537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070537" } ] } ], "protein_names": [ { "name": "Transmembrane protein 247", "type": "recommended", "evidence": [ { "id": "Q2YDG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 247", "type": "synonym", "evidence": [ { "id": "NP_001070537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070537" } ] }, { "name": "transmembrane protein ENSP00000343375 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070537" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDG1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM247", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1", "locus": { "chromosome": "11", "start_pos": 28933551, "end_pos": 28928747, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004105", "url": "https://www.ensembl.org/id/ENSBTAG00000004105" } ] } } ], "crossref": [ { "id": "Q2YDG1", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "768009", "url": "https://www.ncbi.nlm.nih.gov/gene/768009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768009", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768009", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDG1", "url": "https://www.orthodb.org/?gene=Q2YDG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36691:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36691:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070537", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDG1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEDREMMEGRGAGESCPTFPKMAPDDPMSEGKPRASLPQEADTPKPDSSYDYLEEMETCEDGGCPGPPKVLSSKAGPATTKGQAGDGLELAELPSVPATAAPGSPVRERDAEMELEKVRMEFELKRLKYLHEENERQRQHEEVMEQLQQQATPRLFSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMIFFLFSKHYLFCIAAILLCLIKTLWS", "length": 217, "header": "sp|Q2YDG1-1|TM247_BOVIN Isoform 1 of Transmembrane protein 247 OS=Bos taurus OX=9913 GN=TMEM247 PE=2 SV=2 CANONICAL=Q2YDG1-1" }, "isoforms": [ { "isoform_ac": "Q2YDG1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1/entry#Q2YDG1-1", "sequence": { "sequence": "MATEDREMMEGRGAGESCPTFPKMAPDDPMSEGKPRASLPQEADTPKPDSSYDYLEEMETCEDGGCPGPPKVLSSKAGPATTKGQAGDGLELAELPSVPATAAPGSPVRERDAEMELEKVRMEFELKRLKYLHEENERQRQHEEVMEQLQQQATPRLFSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMIFFLFSKHYLFCIAAILLCLIKTLWS", "length": 217, "header": "sp|Q2YDG1-1|TM247_BOVIN Isoform 1 of Transmembrane protein 247 OS=Bos taurus OX=9913 GN=TMEM247 PE=2 SV=2 CANONICAL=Q2YDG1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768009", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768009", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDG1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDG1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDG1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDI3-1", "uniprot_ac": "Q2YDI3", "uniprot_id": "YPEL2_BOVIN", "mass": { "chemical_mass": 13577.0, "monoisotopic_mass": 13577.0 }, "refseq": { "ac": "NP_001072978", "name": "protein yippee-like 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072978" }, "gene_names": [ { "name": "YPEL2", "type": "recommended", "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" } ] }, { "name": "YPEL2", "type": "synonym", "evidence": [ { "id": "NP_001072978", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072978" } ] } ], "protein_names": [ { "name": "Protein yippee-like 2", "type": "recommended", "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3/entry#names_and_taxonomy" } ] }, { "name": "protein yippee-like 2", "type": "synonym", "evidence": [ { "id": "NP_001072978", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072978" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDI3", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YPEL2", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3", "locus": { "chromosome": "19", "start_pos": 10362632, "end_pos": 10314944, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019806", "url": "https://www.ensembl.org/id/ENSBTAG00000019806" } ] } } ], "crossref": [ { "id": "Q2YDI3", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019806", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019806", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616180", "url": "https://www.ncbi.nlm.nih.gov/gene/616180", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616180", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616180", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSRIYGC", "url": "https://omabrowser.org/oma/group/SSRIYGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001072978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072978", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDI3", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDI3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 119, "header": "sp|Q2YDI3-1|YPEL2_BOVIN Isoform 1 of Protein yippee-like 2 OS=Bos taurus OX=9913 GN=YPEL2 PE=3 SV=1 CANONICAL=Q2YDI3-1" }, "isoforms": [ { "isoform_ac": "Q2YDI3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3/entry#Q2YDI3-1", "sequence": { "sequence": "MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 119, "header": "sp|Q2YDI3-1|YPEL2_BOVIN Isoform 1 of Protein yippee-like 2 OS=Bos taurus OX=9913 GN=YPEL2 PE=3 SV=1 CANONICAL=Q2YDI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616180", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616180", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I0R7-1", "protein_name": "Protein yippee-like", "gene_name": "Ypel2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 119 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AAS2-1", "protein_name": "Protein yippee-like", "gene_name": "Ypel2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TAFTCVFRCFPCDPSCGSASWAAPEFAPRSAAPMVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 152 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F3A4-1", "protein_name": "Protein yippee-like", "gene_name": "ypel2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVTMTRSKTFQAYLPNCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKFIIELAHMIKDNGWD", "length": 119 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q55FR5-1", "protein_name": "Protein yippee-like", "gene_name": "ypel", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGRLFKTYLTGPSIICCLNCKTHLTLHDQLISKQFQGRHGTAFLFGTCSNITVGPSEDRTLTTGMHIVADIYCIDCGETLGWKYEFAKEESQKYKVGKYILEKAKIQKEVNFGTQHQPHSLVALENSIM", "length": 129 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q65Z95-1", "protein_name": "Protein yippee-like 2", "gene_name": "Ypel2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 119 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96QA6-1", "protein_name": "Protein yippee-like 2", "gene_name": "YPEL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 119 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W2X7-1", "protein_name": "Protein yippee-like", "gene_name": "Ypel", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVKTFQAYLPSTNRTYSCVHCRAHLASHDELISKSFQGSQGPAYLFNSVVNVACGQTEERVLLTGLHAVADIYCECCKTPLGWKYEHAYESSQKYKEGKFIIELAHMIKENGWD", "length": 114 }, "evidence": [ { "id": "Q2YDI3", "url": "https://omabrowser.org/oma/group/Q2YDI3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI3", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI3", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 119, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDI3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Yippee", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 116, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3#function" }, { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 23, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 23, "end_pos": 23, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3#function" }, { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 26, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 26, "end_pos": 26, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3#function" }, { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 79, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 79, "end_pos": 79, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3#function" }, { "id": "Q2YDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI3" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 82, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 82, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDI7-1", "uniprot_ac": "Q2YDI7", "uniprot_id": "TEKT5_BOVIN", "mass": { "chemical_mass": 56504.0, "monoisotopic_mass": 56504.0 }, "refseq": { "ac": "NP_001039724", "name": "tektin-5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039724" }, "gene_names": [ { "name": "TEKT5", "type": "recommended", "evidence": [ { "id": "Q2YDI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ] }, { "name": "TEKT5", "type": "synonym", "evidence": [ { "id": "NP_001039724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039724" } ] } ], "protein_names": [ { "name": "Tektin-5", "type": "recommended", "evidence": [ { "id": "Q2YDI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7/entry#names_and_taxonomy" } ] }, { "name": "tektin-5", "type": "synonym", "evidence": [ { "id": "NP_001039724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039724" } ] } ], "function": [ { "annotation": "Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme (PubMed:37327785). Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A-tubule of the sperm flagellum (PubMed:37327785).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7#function" }, { "database": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEKT5", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7", "locus": { "chromosome": "25", "start_pos": 9365013, "end_pos": 9414544, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017015", "url": "https://www.ensembl.org/id/ENSBTAG00000017015" } ] } } ], "crossref": [ { "id": "Q2YDI7", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "521940", "url": "https://www.ncbi.nlm.nih.gov/gene/521940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521940", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521940", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDI7", "url": "https://www.orthodb.org/?gene=Q2YDI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19960", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19960", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19960:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19960:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF03148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFLGTTQTATYCGPKKPCGGSVLPSVASGPTVQECYQPYYLPGYRYLNAWRPSLFYKVANAQTCLDEGATCRSALRPPTILPAVRSALFCRYSPQDWDQSNRLQLCGAEASRLWAGRMTGDSMRLMQDKDQLTRQMQEGTCRNLGQRLSDIGFWKSELNYELERLLNENHSLDAIKRRLECAAEELRCPLQVALECLYQREKRIGIDLVHDNVEKNLIREVDMIKCCQEQMRKLAQRIDIQMRENRDAQHALERDLEDKNSAEFIDEKCLNLRNTSDCISFFHGVEKIDGTISVPETWAKFSNDNIRHSQNMRANSIRLREEAQNLFDVLADQLWRQFTNTNLAFNARIAEETDVKNKLQTQLAKTLQEIFQTENTIMLLERSIMAKECPLKVAQTRLECRTRRPNVELCRDSPQFKLVNEVFTIDDTLQTLKLRLRETRDTLQLLVMTKCRLEHELAIKANTLCIDKEKCMAMRKTFPSTPCMGICP", "length": 489, "header": "sp|Q2YDI7-1|TEKT5_BOVIN Isoform 1 of Tektin-5 OS=Bos taurus OX=9913 GN=TEKT5 PE=1 SV=1 CANONICAL=Q2YDI7-1" }, "isoforms": [ { "isoform_ac": "Q2YDI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7/entry#Q2YDI7-1", "sequence": { "sequence": "MEFLGTTQTATYCGPKKPCGGSVLPSVASGPTVQECYQPYYLPGYRYLNAWRPSLFYKVANAQTCLDEGATCRSALRPPTILPAVRSALFCRYSPQDWDQSNRLQLCGAEASRLWAGRMTGDSMRLMQDKDQLTRQMQEGTCRNLGQRLSDIGFWKSELNYELERLLNENHSLDAIKRRLECAAEELRCPLQVALECLYQREKRIGIDLVHDNVEKNLIREVDMIKCCQEQMRKLAQRIDIQMRENRDAQHALERDLEDKNSAEFIDEKCLNLRNTSDCISFFHGVEKIDGTISVPETWAKFSNDNIRHSQNMRANSIRLREEAQNLFDVLADQLWRQFTNTNLAFNARIAEETDVKNKLQTQLAKTLQEIFQTENTIMLLERSIMAKECPLKVAQTRLECRTRRPNVELCRDSPQFKLVNEVFTIDDTLQTLKLRLRETRDTLQLLVMTKCRLEHELAIKANTLCIDKEKCMAMRKTFPSTPCMGICP", "length": 489, "header": "sp|Q2YDI7-1|TEKT5_BOVIN Isoform 1 of Tektin-5 OS=Bos taurus OX=9913 GN=TEKT5 PE=1 SV=1 CANONICAL=Q2YDI7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 32, "start_aa": "Thr", "end_pos": 32, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr32", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023-06-22", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:521940", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521940", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium movement involved in cell motility", "id": "GO:0060294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060294", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI7", "url": "https://www.uniprot.org/uniprotkb/Q2YDI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 489, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDI7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 32 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 275, "end_pos": 277 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2YDK0-1", "uniprot_ac": "Q2YDK0", "uniprot_id": "FHL5_BOVIN", "mass": { "chemical_mass": 32810.0, "monoisotopic_mass": 32810.0 }, "refseq": { "ac": "NP_001069847", "name": "four and a half LIM domains protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069847" }, "gene_names": [ { "name": "FHL5", "type": "recommended", "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ] }, { "name": "FHL5", "type": "synonym", "evidence": [ { "id": "NP_001069847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069847" } ] } ], "protein_names": [ { "name": "Four and a half LIM domains protein 5", "type": "recommended", "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0/entry#names_and_taxonomy" } ] }, { "name": "FHL-5", "type": "synonym", "evidence": [ { "id": "NP_001069847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069847" }, { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0/entry#names_and_taxonomy" } ] }, { "name": "four and a half LIM domains protein 5", "type": "synonym", "evidence": [ { "id": "NP_001069847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069847" } ] } ], "function": [ { "annotation": "May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FHL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0", "locus": { "chromosome": "9", "start_pos": 53186120, "end_pos": 53239319, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001803", "url": "https://www.ensembl.org/id/ENSBTAG00000001803" } ] } } ], "crossref": [ { "id": "Q2YDK0", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09346", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09346", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09347", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09347", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09428", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615499", "url": "https://www.ncbi.nlm.nih.gov/gene/615499", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615499", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615499", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERCFNCA", "url": "https://omabrowser.org/oma/group/ERCFNCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDK0", "url": "https://www.orthodb.org/?gene=Q2YDK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24205:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24205:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069847", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDK0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTPQFYCQYCMASLLGKKYVLKDDNPYCVSCYDRIFSNYCEECKEPIESGSKDLCYKGHHWHEGCFNCTKCNHSLVEKPFAAKDERLLCSECYSNECSSKCFHCKKTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKESGNYCVPCFEKEFAHYCSFCKKVITSGGITFRDQPWHKECFLCSGCRKELCEEEFMSRDDYPFCLDCYNHLYAKKCAACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTHNKEIFCRKCGSGVDTDI", "length": 284, "header": "sp|Q2YDK0-1|FHL5_BOVIN Isoform 1 of Four and a half LIM domains protein 5 OS=Bos taurus OX=9913 GN=FHL5 PE=2 SV=1 CANONICAL=Q2YDK0-1" }, "isoforms": [ { "isoform_ac": "Q2YDK0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0/entry#Q2YDK0-1", "sequence": { "sequence": "MTTPQFYCQYCMASLLGKKYVLKDDNPYCVSCYDRIFSNYCEECKEPIESGSKDLCYKGHHWHEGCFNCTKCNHSLVEKPFAAKDERLLCSECYSNECSSKCFHCKKTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKESGNYCVPCFEKEFAHYCSFCKKVITSGGITFRDQPWHKECFLCSGCRKELCEEEFMSRDDYPFCLDCYNHLYAKKCAACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTHNKEIFCRKCGSGVDTDI", "length": 284, "header": "sp|Q2YDK0-1|FHL5_BOVIN Isoform 1 of Four and a half LIM domains protein 5 OS=Bos taurus OX=9913 GN=FHL5 PE=2 SV=1 CANONICAL=Q2YDK0-1" }, "locus": { "chromosome": "9", "start_pos": 53200079, "end_pos": 53186186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002359.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002359.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002359.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002359.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615499", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615499", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VD49-1", "protein_name": "Four and a half LIM domains protein 5", "gene_name": "FHL5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTAQFDCQYCTASLLGKKYVLKDDNPYCVSCYDRIFSNYCEECKEPIESDSKDLCYKGRHWHEGCFNCAKCNHSLVEKPFAAKDERLLCSECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKENGNYCVPCFEKEFAHYCSFCKKVITSGGITFHDQPWHKECFLCSGCRKELCEEEFMSKDDYPFCLDCYNHLYAKKCSACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTQNKEIFCRKCGSGVDADN", "length": 284 }, "evidence": [ { "id": "Q2YDK0", "url": "https://omabrowser.org/oma/group/Q2YDK0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1C1I0-1", "protein_name": "Four and a half LIM domains protein 5", "gene_name": "FHL5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSNHSDCHYCLQSLRGRKYALKEENAYCVRCYDSLFANSCEECKEPIECDSKDLAYKGRHWHERCFKCTKCSRSLVEKPFAAKDELLLCTECYSNEYSSKCFHCQKTIMPGSRKMEFKGSSWHESCFVCQYCQQPLGTKPLITKDNENYCVPCFEKQFAHRCYSCKKVITSGGVAYHDQPWHKECFVCAGCKTQLSGQRFVSKDEYPYCVDCFSKFYAKKCTACKKPITALGGAKFVSFEECQWHEECFNCARCSVSLVGQGFLTKQDAVLCHECGSS", "length": 279 }, "evidence": [ { "id": "Q2YDK0", "url": "https://omabrowser.org/oma/group/Q2YDK0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5TD97-1", "protein_name": "Four and a half LIM domains protein 5", "gene_name": "FHL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI", "length": 284 }, "evidence": [ { "id": "Q2YDK0", "url": "https://omabrowser.org/oma/group/Q2YDK0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WTX7-1", "protein_name": "Four and a half LIM domains protein 5", "gene_name": "Fhl5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSSQFDCQYCTSSLIGKKYVLKDDNLYCISCYDRIFSNYCEQCKEPIESDSKDLCYKNRHWHEGCFRCNKCHHSLVEKPFVAKDDRLLCTDCYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFRDQIWHKECFLCSGCRKELYEEAFMSKDDFPFCLDCYNHLYAKKCAACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTHNMEILCRKCGSGADTDA", "length": 284 }, "evidence": [ { "id": "Q2YDK0", "url": "https://omabrowser.org/oma/group/Q2YDK0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK0", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDK0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 284, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDK0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDK0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 1", "eco_id": "ECO_0000255", "start_pos": 39, "end_pos": 100, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 2", "eco_id": "ECO_0000255", "start_pos": 101, "end_pos": 160, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 3", "eco_id": "ECO_0000255", "start_pos": 161, "end_pos": 220, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK0" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding 4", "eco_id": "ECO_0000255", "start_pos": 223, "end_pos": 283, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDK1-1", "uniprot_ac": "Q2YDK1", "uniprot_id": "I20L2_BOVIN", "mass": { "chemical_mass": 38639.0, "monoisotopic_mass": 38639.0 }, "refseq": { "ac": "NP_001039682", "name": "interferon-stimulated 20 kDa exonuclease-like 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039682" }, "gene_names": [ { "name": "ISG20L2", "type": "recommended", "evidence": [ { "id": "Q2YDK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ] }, { "name": "ISG20L2", "type": "synonym", "evidence": [ { "id": "NP_001039682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039682" } ] } ], "protein_names": [ { "name": "Interferon-stimulated 20 kDa exonuclease-like 2", "type": "recommended", "evidence": [ { "id": "Q2YDK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "Q2YDK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1/entry#names_and_taxonomy" } ] }, { "name": "interferon stimulated exonuclease gene 20kDa-like 2", "type": "synonym", "evidence": [ { "id": "NP_001039682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039682" } ] }, { "name": "interferon-stimulated 20 kDa exonuclease-like 2", "type": "synonym", "evidence": [ { "id": "NP_001039682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039682" } ] } ], "function": [ { "annotation": "3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISG20L2", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1", "locus": { "chromosome": "3", "start_pos": 14111430, "end_pos": 14106347, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001518", "url": "https://www.ensembl.org/id/ENSBTAG00000001518" } ] } } ], "crossref": [ { "id": "Q2YDK1", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001518", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06149", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06149", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515980", "url": "https://www.ncbi.nlm.nih.gov/gene/515980", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515980", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515980", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCPIVDY", "url": "https://omabrowser.org/oma/group/PCPIVDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDK1", "url": "https://www.orthodb.org/?gene=Q2YDK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00929", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00929", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDK1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTLLLNLDFGEPPPKKALEGNAKHRKFVKKRRLLERKGFLNKKKQPPSKVPKLHSEPSQKGETPRVDGTWKATPLPKKKTTAASSSGSEQSLDKKAAVPWLTPAPSQKAGSVVAKVDLLGEFQSALPKIKSHPTRPQKKGSQKNPPPKNGPQNSTHTHSENKYSGVSQKIPGKMVAIDCEMVGTGPKGHVSSLARCSIVNYDGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARNQILKILAGKIVVGHAIHNDFKALQYIHPKSLTRDTSHIPLLNRKADCPENATMSLKSLTKKLLNRDIQAGKSGHSSVEDAQATMELYKLVEVEWEQHLAQNPPKD", "length": 349, "header": "sp|Q2YDK1-1|I20L2_BOVIN Isoform 1 of Interferon-stimulated 20 kDa exonuclease-like 2 OS=Bos taurus OX=9913 GN=ISG20L2 PE=2 SV=1 CANONICAL=Q2YDK1-1" }, "isoforms": [ { "isoform_ac": "Q2YDK1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1/entry#Q2YDK1-1", "sequence": { "sequence": "MSTLLLNLDFGEPPPKKALEGNAKHRKFVKKRRLLERKGFLNKKKQPPSKVPKLHSEPSQKGETPRVDGTWKATPLPKKKTTAASSSGSEQSLDKKAAVPWLTPAPSQKAGSVVAKVDLLGEFQSALPKIKSHPTRPQKKGSQKNPPPKNGPQNSTHTHSENKYSGVSQKIPGKMVAIDCEMVGTGPKGHVSSLARCSIVNYDGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARNQILKILAGKIVVGHAIHNDFKALQYIHPKSLTRDTSHIPLLNRKADCPENATMSLKSLTKKLLNRDIQAGKSGHSSVEDAQATMELYKLVEVEWEQHLAQNPPKD", "length": 349, "header": "sp|Q2YDK1-1|I20L2_BOVIN Isoform 1 of Interferon-stimulated 20 kDa exonuclease-like 2 OS=Bos taurus OX=9913 GN=ISG20L2 PE=2 SV=1 CANONICAL=Q2YDK1-1" }, "locus": { "chromosome": "3", "start_pos": 14110646, "end_pos": 14107081, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001989.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001989.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001989.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001989.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515980", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515980", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RHI9-1", "protein_name": "Interferon stimulated exonuclease 20 like 2", "gene_name": "ISG20L2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSTLLLNLDFGEPPPKKALEGNAKHRKFVKKRRLLERKGFLNKKQQPPSKVAKLQSESSKKGKSPKVDGAWKAPLLSKKKTAASSGGSGQSLDKPSAVPWLTPAPSQKAGSVVAKVDLLGEFQSALPKIKSHPTRPRKKGSQKNAPQNSTQAHSEKKYSGASQKGPSKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARSQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPLLNRKADCPENATMSLKRLTKKLLDRDIQVGKSGHSSVEDAQATMELYKLVEVEWEQHLIQNPPKD", "length": 343 }, "evidence": [ { "id": "Q2YDK1", "url": "https://omabrowser.org/oma/group/Q2YDK1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U1G5-1", "protein_name": "Interferon-stimulated 20 kDa exonuclease-like 2", "gene_name": "Isg20l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTILLNLDFGQPSKKAFGGNAKHQRFVKKRRFLEQKGFLNKKNQPPNKVSKLNSEPPKKGETSRVDGILKILPCPKKKEAAASKRDSERSKDKKAPLSWLTPAPSKKTASVVSKIDLLGEFQSALPKTKSTQKKGSKKKSLKKKIATENSTQAQSKDKGSKKKPLKKNAVPNSTQARSEDKCPTVPQNLPGKMVAIDCEMVGTGPKGRVSSLARCSIVNYNGDVLYDEYVLPPCYIVNYRTRWSGIRKCHMVNATPFKTARSQILKILSGKVVIGHAIHNDYKALQYFHPKSLTRDTSRIPLLNRKADCPENVTLSLKHLTKKLLSRDIQVGNTGHSSVEDAQATMELYKLVEVEWEQHLAQNPPEN", "length": 368 }, "evidence": [ { "id": "Q2YDK1", "url": "https://omabrowser.org/oma/group/Q2YDK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AXU3-1", "protein_name": "Interferon-stimulated 20 kDa exonuclease-like 2", "gene_name": "Isg20l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTILLNLDFGEPSKKAFGGNAKHQRFVKKRRFLEQKGFLSKKNQPPSKVSKLNSEPPKKGETSRVDSISKILSCLKKKKEAAASKRDSEQSKDKKASLSWLTPAPSKKTDSVVAKIDLLGEFQSALPKPKRRTQKKGSKKPLKKKIATENSTQTQSKDKGSNKKPLKKNAVQNSTQAQPEDKCPKVPQSLPRKMVAIDCEMVGTGPKGRVSSLARCSIVNYNGDVLYDEYIRPPCYIVDYRTRWSGIRKCHMVNATPFKTARSQILKILSGKVVVGHAIHNDYKALQYFHPKSLTRDTSQIPLLNRKADCPENVTLSLKHLTKKLLSRDIQTGLSGHSSVEDAQATLELYKLVEVEWEQHLAQNPPEN", "length": 369 }, "evidence": [ { "id": "Q2YDK1", "url": "https://omabrowser.org/oma/group/Q2YDK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H9L3-1", "protein_name": "Interferon-stimulated 20 kDa exonuclease-like 2", "gene_name": "ISG20L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSKKGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLGEFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNSTQAHSENKCSGASQKLPRKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLARNPPTD", "length": 353 }, "evidence": [ { "id": "Q2YDK1", "url": "https://omabrowser.org/oma/group/Q2YDK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" }, { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" }, { "name": "exonuclease activity", "id": "GO:0004527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004527", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" }, { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-6791218", "name": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPN0-1", "Q2YDK1-1" ], "evidence": [ { "id": "R-BTA-6791218", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791218" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BPN0", "gene_name": "NOL9", "activity": [ { "ec_number": "2.7.1.78", "activity": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+).", "evidence": [ { "id": "E1BPN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPN0" } ] }, { "ec_number": "2.7.1.78", "activity": "", "evidence": [ { "id": "E1BPN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPN0" } ] } ] }, { "uniprot_ac": "Q2YDK1", "gene_name": "ISG20L2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q2YDK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDK1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 294, "end_pos": 296 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDK4-1", "uniprot_ac": "Q2YDK4", "uniprot_id": "HMGN4_BOVIN", "mass": { "chemical_mass": 9583.0, "monoisotopic_mass": 9583.0 }, "refseq": { "ac": "NP_001040012", "name": "high mobility group nucleosome-binding domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040012" }, "gene_names": [ { "name": "HMGN4", "type": "recommended", "evidence": [ { "id": "Q2YDK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ] }, { "name": "HMGN4", "type": "synonym", "evidence": [ { "id": "NP_001040012", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040012" } ] } ], "protein_names": [ { "name": "High mobility group nucleosome-binding domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q2YDK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4/entry#names_and_taxonomy" } ] }, { "name": "high mobility group nucleosome-binding domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001040012", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040012" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HMGN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4", "locus": { "chromosome": "23", "start_pos": 31565100, "end_pos": 31574718, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031747", "url": "https://www.ensembl.org/id/ENSBTAG00000031747" } ] } } ], "crossref": [ { "id": "Q2YDK4", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031747", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031747", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614918", "url": "https://www.ncbi.nlm.nih.gov/gene/614918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614918", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614918", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDK4", "url": "https://www.orthodb.org/?gene=Q2YDK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23087", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23087", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23087:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23087:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01101", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01101", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040012", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TE66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDK4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKRKAKGDAKGDKGKVKDEPQRRSARLSAKPALPKPEPRPKKAPAKKGEKLAKGRKGKAEVSKDGNNPAKNRDASTVQSQKAEGTGDAK", "length": 90, "header": "sp|Q2YDK4-1|HMGN4_BOVIN Isoform 1 of High mobility group nucleosome-binding domain-containing protein 4 OS=Bos taurus OX=9913 GN=HMGN4 PE=3 SV=3 CANONICAL=Q2YDK4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TE66-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4/entry#A0AAA9TE66-1", "sequence": { "sequence": "MSHRGDQHGCLLNLPFQNRSPGQKRPLQRRERSWPKGERGKQKSARMGTTLRKTEMPLQSSHRKQKALGMPNEVYLFDSSVLLVTLLFEILFLNQIL", "length": 97, "header": "tr|A0AAA9TE66-1|A0AAA9TE66_BOVIN Computationally mapped isoform of High mobility group nucleosomal binding domain 4 OS=Bos taurus OX=9913 GN=HMGN4 PE=4 SV=1 CANONICAL=Q2YDK4-1" }, "locus": { "chromosome": "23", "start_pos": 31567341, "end_pos": 31567072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045015.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045015.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042444.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042444.2" } ] } }, { "isoform_ac": "Q2YDK4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4/entry#Q2YDK4-1", "sequence": { "sequence": "MPKRKAKGDAKGDKGKVKDEPQRRSARLSAKPALPKPEPRPKKAPAKKGEKLAKGRKGKAEVSKDGNNPAKNRDASTVQSQKAEGTGDAK", "length": 90, "header": "sp|Q2YDK4-1|HMGN4_BOVIN Isoform 1 of High mobility group nucleosome-binding domain-containing protein 4 OS=Bos taurus OX=9913 GN=HMGN4 PE=3 SV=3 CANONICAL=Q2YDK4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "site_lbl": "Ser80" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614918", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614918", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "pmid": "" }, { "name": "nucleosomal DNA binding", "id": "GO:0031492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031492", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q2YDK4", "url": "https://www.uniprot.org/uniprotkb/Q2YDK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDK4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 90, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDK4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDK4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 80 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDL1-1", "uniprot_ac": "Q2YDL1", "uniprot_id": "STXB6_BOVIN", "mass": { "chemical_mass": 23667.0, "monoisotopic_mass": 23667.0 }, "refseq": { "ac": "NP_001069506", "name": "syntaxin-binding protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069506" }, "gene_names": [ { "name": "STXBP6", "type": "recommended", "evidence": [ { "id": "Q2YDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" } ] }, { "name": "STXBP6", "type": "synonym", "evidence": [ { "id": "NP_001069506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069506" } ] } ], "protein_names": [ { "name": "Syntaxin-binding protein 6", "type": "recommended", "evidence": [ { "id": "Q2YDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1/entry#names_and_taxonomy" } ] }, { "name": "syntaxin binding protein 6 (amisyn)", "type": "synonym", "evidence": [ { "id": "NP_001069506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069506" } ] }, { "name": "syntaxin-binding protein 6", "type": "synonym", "evidence": [ { "id": "NP_001069506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069506" } ] } ], "function": [ { "annotation": "Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STXBP6", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1", "locus": { "chromosome": "21", "start_pos": 35027776, "end_pos": 35306047, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021291", "url": "https://www.ensembl.org/id/ENSBTAG00000021291" } ] } } ], "crossref": [ { "id": "Q2YDL1", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14681", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14681", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15892", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15892", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534718", "url": "https://www.ncbi.nlm.nih.gov/gene/534718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534718", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDL1", "url": "https://www.orthodb.org/?gene=Q2YDL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16092:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16092:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00957", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00957", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15277", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15277", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069506", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDL1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVKGIDPNRDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC", "length": 210, "header": "sp|Q2YDL1-1|STXB6_BOVIN Isoform 1 of Syntaxin-binding protein 6 OS=Bos taurus OX=9913 GN=STXBP6 PE=2 SV=1 CANONICAL=Q2YDL1-1" }, "isoforms": [ { "isoform_ac": "Q2YDL1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1/entry#Q2YDL1-1", "sequence": { "sequence": "MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVKGIDPNRDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC", "length": 210, "header": "sp|Q2YDL1-1|STXB6_BOVIN Isoform 1 of Syntaxin-binding protein 6 OS=Bos taurus OX=9913 GN=STXBP6 PE=2 SV=1 CANONICAL=Q2YDL1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534718", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of SNARE complex assembly", "id": "GO:0035542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035542", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDL1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 210, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDL1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDL1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL1" }, { "id": "PRU00290", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "v-SNARE coiled-coil homology", "eco_id": "ECO_0000255", "start_pos": 151, "end_pos": 210, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDM2-1", "uniprot_ac": "Q2YDM2", "uniprot_id": "INT11_BOVIN", "mass": { "chemical_mass": 67601.0, "monoisotopic_mass": 67601.0 }, "refseq": {}, "gene_names": [ { "name": "INTS11", "type": "recommended", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ] }, { "name": "CPSF3L", "type": "synonym", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 11", "type": "recommended", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#names_and_taxonomy" } ] }, { "name": "3.1.27.-", "type": "synonym", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#names_and_taxonomy" } ] }, { "name": "CPSF3-like protein", "type": "synonym", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#names_and_taxonomy" } ] }, { "name": "Cleavage and polyadenylation-specific factor 3-like protein", "type": "synonym", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#names_and_taxonomy" } ] }, { "name": "Int11", "type": "synonym", "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "database": "UniProtKB", "id": "Q5TA45", "url": "https://www.uniprot.org/uniprotkb/Q5TA45#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS11", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2", "locus": { "chromosome": "16", "start_pos": 51211949, "end_pos": 51201649, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007620", "url": "https://www.ensembl.org/id/ENSBTAG00000007620" } ] } } ], "crossref": [ { "id": "Q2YDM2", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16291", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16291", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q2YDM2", "url": "https://www.orthodb.org/?gene=Q2YDM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11203", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11203", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11203:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11203:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFSDDRRFPDFSYNTRSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTQPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPSLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMDLKAPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADSPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPENVLLVHGEAKKMEFLKQKIEQEFRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPDAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQEMAMRVYSHLKSVLKDHCVQHLPDGSVTVESILVQAAAHSEDPGTKVLLVSWTYQDEELGSYLTSLLKKGLPQAS", "length": 599, "header": "sp|Q2YDM2-1|INT11_BOVIN Isoform 1 of Integrator complex subunit 11 OS=Bos taurus OX=9913 GN=INTS11 PE=2 SV=2 CANONICAL=Q2YDM2-1" }, "isoforms": [ { "isoform_ac": "Q2YDM2-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2/entry#Q2YDM2-1", "sequence": { "sequence": "MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFSDDRRFPDFSYNTRSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTQPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPSLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMDLKAPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADSPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPENVLLVHGEAKKMEFLKQKIEQEFRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPDAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQEMAMRVYSHLKSVLKDHCVQHLPDGSVTVESILVQAAAHSEDPGTKVLLVSWTYQDEELGSYLTSLLKKGLPQAS", "length": 599, "header": "sp|Q2YDM2-1|INT11_BOVIN Isoform 1 of Integrator complex subunit 11 OS=Bos taurus OX=9913 GN=INTS11 PE=2 SV=2 CANONICAL=Q2YDM2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "INTAC complex", "id": "GO:0160232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160232", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "snRNA processing", "id": "GO:0016180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016180", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" }, { "name": "RNA polymerase II transcription initiation surveillance", "id": "GO:0160240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160240", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM2", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDM2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 599, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDM2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDM2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 469, "end_pos": 479, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 157, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 157, "end_pos": 157, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 178, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 178, "end_pos": 178, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 414, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 414, "end_pos": 414, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 68, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 68, "end_pos": 68, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 70, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 70, "end_pos": 70, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 72, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 72, "end_pos": 72, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2#function" }, { "id": "Q2YDM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM2" } ], "binding_site_uniprot": 73, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 73, "end_pos": 73, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDM3-1", "uniprot_ac": "Q2YDM3", "uniprot_id": "M4A13_BOVIN", "mass": { "chemical_mass": 17429.0, "monoisotopic_mass": 17429.0 }, "refseq": { "ac": "NP_001068688", "name": "membrane-spanning 4-domains subfamily A member 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068688" }, "gene_names": [ { "name": "MS4A13", "type": "recommended", "evidence": [ { "id": "Q2YDM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3" } ] }, { "name": "MS4A13", "type": "synonym", "evidence": [ { "id": "NP_001068688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068688" } ] } ], "protein_names": [ { "name": "Membrane-spanning 4-domains subfamily A member 13", "type": "recommended", "evidence": [ { "id": "Q2YDM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3/entry#names_and_taxonomy" } ] }, { "name": "membrane-spanning 4-domains subfamily A member 13", "type": "synonym", "evidence": [ { "id": "NP_001068688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068688" } ] }, { "name": "membrane-spanning 4-domains, subfamily A, member 13", "type": "synonym", "evidence": [ { "id": "NP_001068688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068688" } ] } ], "function": [ { "annotation": "May be involved in signal transduction as a component of a multimeric receptor complex.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM3", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDM3", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MS4A13", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3", "locus": { "chromosome": "15", "start_pos": 83357744, "end_pos": 83332960, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030898", "url": "https://www.ensembl.org/id/ENSBTAG00000030898" } ] } } ], "crossref": [ { "id": "Q2YDM3", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "505705", "url": "https://www.ncbi.nlm.nih.gov/gene/505705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:505705", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDM3", "url": "https://www.orthodb.org/?gene=Q2YDM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "NP_001068688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068688", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDM3", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFFIISGISIIRATWYPSQRQLTCAMLENILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 153, "header": "sp|Q2YDM3-1|M4A13_BOVIN Isoform 1 of Membrane-spanning 4-domains subfamily A member 13 OS=Bos taurus OX=9913 GN=MS4A13 PE=2 SV=1 CANONICAL=Q2YDM3-1" }, "isoforms": [ { "isoform_ac": "Q2YDM3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3/entry#Q2YDM3-1", "sequence": { "sequence": "MTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFFIISGISIIRATWYPSQRQLTCAMLENILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 153, "header": "sp|Q2YDM3-1|M4A13_BOVIN Isoform 1 of Membrane-spanning 4-domains subfamily A member 13 OS=Bos taurus OX=9913 GN=MS4A13 PE=2 SV=1 CANONICAL=Q2YDM3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505705", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505705", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM3", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM3", "url": "https://www.uniprot.org/uniprotkb/Q2YDM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDM3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDN4-1", "uniprot_ac": "Q2YDN4", "uniprot_id": "TEKL1_BOVIN", "mass": { "chemical_mass": 57643.0, "monoisotopic_mass": 57643.0 }, "refseq": { "ac": "NP_001039757", "name": "tektin-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757" }, "gene_names": [ { "name": "TEKTL1", "type": "recommended", "evidence": [ { "id": "Q2YDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ] }, { "name": "CCDC105", "type": "synonym", "evidence": [ { "id": "NP_001039757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757" }, { "id": "Q2YDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ] }, { "name": "TEKTL1", "type": "synonym", "evidence": [ { "id": "NP_001039757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757" } ] } ], "protein_names": [ { "name": "Tektin-like protein 1", "type": "recommended", "evidence": [ { "id": "Q2YDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 105", "type": "synonym", "evidence": [ { "id": "Q2YDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 105", "type": "synonym", "evidence": [ { "id": "NP_001039757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757" } ] }, { "name": "tektin-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in sperm flagellar axoneme, which is required for motile flagellum beating (PubMed:37327785). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (PubMed:37327785).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4#function" }, { "database": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEKTL1", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4", "locus": {} } ], "crossref": [ { "id": "Q2YDN4", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020615", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020615", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528661", "url": "https://www.ncbi.nlm.nih.gov/gene/528661", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR038949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528661", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528661", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YTPECAT", "url": "https://omabrowser.org/oma/group/YTPECAT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDN4", "url": "https://www.orthodb.org/?gene=Q2YDN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35081", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35081", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35081:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35081:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF03148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039757", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDN4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVLIPPVEHSQDTRVGHPAWREATRALAEEAHQLTDRCGQEAVTMWQPNESVRDPHVAHHLCRAAYILPWRFRVEMLKGGSTMEKPPPGEGVTLWKSKMKPPAWHARLPLPMHRDARALQTAEVVQAHARGARLTAARLGRAQHQINGQLRLLQRQREATDRRLSEVRKALLINQQSVKLRGYRPKSETISDKADSMLTWEKEELKSMKRKMEADMEKSEALLKTLASCRDALVFCCKERLQAVELMNQPLDKVLEQAGRHSWVNISRVPTPRTQGLKTPPPDPVGTYTPECAKALYEAKRLLMESKDTLLDMAKNEEDIREQQQQISDRVCASLAQKMRETLELKDRLNMTLGLMRGTIHRCTKFNQEMYITRGLIKGPLSKSHLETREKLDRPLVRMYQRHVGTQLPEAARLAQGTDKLQRHISHVEKNLDELLSMRKKLTWSFNCKKIGHNVDYSVVRLRLRQRHPQVCYEQAQRLVNDWDPRTPPRVKSNTAITK", "length": 500, "header": "sp|Q2YDN4-1|TEKL1_BOVIN Isoform 1 of Tektin-like protein 1 OS=Bos taurus OX=9913 GN=TEKTL1 PE=1 SV=1 CANONICAL=Q2YDN4-1" }, "isoforms": [ { "isoform_ac": "Q2YDN4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4/entry#Q2YDN4-1", "sequence": { "sequence": "MPVLIPPVEHSQDTRVGHPAWREATRALAEEAHQLTDRCGQEAVTMWQPNESVRDPHVAHHLCRAAYILPWRFRVEMLKGGSTMEKPPPGEGVTLWKSKMKPPAWHARLPLPMHRDARALQTAEVVQAHARGARLTAARLGRAQHQINGQLRLLQRQREATDRRLSEVRKALLINQQSVKLRGYRPKSETISDKADSMLTWEKEELKSMKRKMEADMEKSEALLKTLASCRDALVFCCKERLQAVELMNQPLDKVLEQAGRHSWVNISRVPTPRTQGLKTPPPDPVGTYTPECAKALYEAKRLLMESKDTLLDMAKNEEDIREQQQQISDRVCASLAQKMRETLELKDRLNMTLGLMRGTIHRCTKFNQEMYITRGLIKGPLSKSHLETREKLDRPLVRMYQRHVGTQLPEAARLAQGTDKLQRHISHVEKNLDELLSMRKKLTWSFNCKKIGHNVDYSVVRLRLRQRHPQVCYEQAQRLVNDWDPRTPPRVKSNTAITK", "length": 500, "header": "sp|Q2YDN4-1|TEKL1_BOVIN Isoform 1 of Tektin-like protein 1 OS=Bos taurus OX=9913 GN=TEKTL1 PE=1 SV=1 CANONICAL=Q2YDN4-1" }, "locus": { "chromosome": "7", "start_pos": 8158211, "end_pos": 8148835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027472.4", "url": "https://www.ensembl.org/id/ENSBTAT00000027472.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027472.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027472.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 372, "end_pos": 372, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "site_lbl": "Tyr372" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023-06-22", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:528661", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528661", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E7F4M4-1", "protein_name": "Tektin-like protein 1", "gene_name": "tektl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKRRVQSAPQAVVVGPKGWRDATVRSIQRAENLLRQTHVDQLDSSTRYRSHSVAISAYRLPQLTAYSGDESMEKEHSETDWEKKEEFWPKSTGSLLTSGLIGGPFPPPVLREQSAVVSTGLAADYMRSVREVEGHLRKQTGRVTQEATKVEHQRERLEKLLRSLRKALLVNQQSANGRTFRPATTETGRDGADDLLQTERRGLNMLKQELESMLRKTLAQQQALADSSKQLLDCAFLRSSVTELLPQHGSLLAGVKTYPSPLSLKPDPAGPFTPECKQALDSSSAVLQESQQLRENITQVMSDVIRKQTDMHRSASEALLRKITETINLEQHLTLSSAATRQAIYRKQRQMQCAGYSLGRALGPVCRADLFCRERLNRPMTQLYGRHSSVGLPESDLLAQGDTMLRKHLESSGKEIAALQDAHQQLEDDMYGKRAAAGVDSAVVRLRRRLVRPQSVRPATS", "length": 461 }, "evidence": [ { "id": "Q2YDN4", "url": "https://omabrowser.org/oma/group/Q2YDN4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SAN2-1", "protein_name": "Coiled-coil domain containing 105", "gene_name": "CCDC105", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPVEHSPDVRVGPPAWREAAKAIIQKAHQLNDRCGQEAVTMWQPKDSVQDPHMARHLCRAAYILPWRFRVEMLKGGGTMEQPPPGEGVTLWKNKMKPPAWHARLPLPMHRDARALQTAEVVHAHARGARLTAARLGRAQQQINGQMRLLQRQREATDHRLSEVRKGLLINQQSVKLRGYRPKSEKIPDKADTMLTWEKEELKSMKRKMEKDMEKSEALLKTLASCRETLIFCCEERLQAVELMNQPLDKVLEQACRHSWVNLSRVPTPRTQGLKTPPPDPVGTYTPECATALYEAKQLLMESKDTLLDMAKNEEDIREQQQQISDRVCASIAQKMRETLELKDKMNMTLGLMRRTIHRCTKFNQEMYITHGLTKGPLSKTHLETREKLDRPLVRVYQRHVGTQLPEATRLAQGTDKLQRHISLAEKNLKELLAARKNLTWSLNCKKIGHEVDDNVVRLRLRQRHPQVCYEQAQRLVSDWDPRTPPRWESSAAAK", "length": 495 }, "evidence": [ { "id": "Q2YDN4", "url": "https://omabrowser.org/oma/group/Q2YDN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4V7B5-1", "protein_name": "Tektin-like protein 1", "gene_name": "Tektl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVLLPSTDRDQDSRVGAPEWHQAAKATSRKAHLLTDRCGKEAVTMWQPKDSVLDPNVAHHLGRAAYMEPWRFRVEMLKGGGTVEKPPPGEGVTLWKGKMKPPAWYARLPLPMHRDARAQQTAEVVHAHARGARLTAARLGRAQHQINGQLRLLLRQREATDRRLSEVRKGLLINEQSVKLRGYRPKCEKIPDKADSMLVWEREELKSMKRKMEKDMERSEALLKALASCRDTLDFYCQERLQAVGLMNQPLDKVLEQAGRHSWVDITRPPTPRTQGLKTPPPDPVGAYTPACAKALFEAKRLLMESKDILAELAKNEVDIQNQQQEISDRVCNSLAQKMRETLELKERMTMTLGLMRGTIHRCMKFNQEMYVTRGLIKGPLLKRDLEAREKLNRPLVRMYQRHVGTQLPEATRLAQGTDLLTRHNLQMEKNLKELRTTHDNLAWSLNCKKIGHDVDYDVVRLRLRQLHPHVCYEQAKRLINDWDPRTPPPCSRTNTSSK", "length": 500 }, "evidence": [ { "id": "Q2YDN4", "url": "https://omabrowser.org/oma/group/Q2YDN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IYK2-1", "protein_name": "Tektin-like protein 1", "gene_name": "TEKTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVLVPPAERSQDTRVGAPAWREAAQAMARTAHILTDRCGQEAVTMWQPKDSVLDPNVAHHLGRAAYIQPWRFRVEMIKGGGTLEKPPPGEGVTLWKGKMKPPAWYARLPLPLHRKARALQTTEVVHAHARGARLTAARLGRAQHQINGRVRQLLRQREVTDHRLSEVRKGLLINQQSVKLRGYRPKSEKVPDKADSMLTWEKEELKSMKRKMERDMEKSEVLLKTLASCRDTLNFCFKERLQAVDLMNQPLDKVLEQARRHSWVNLSRAPTPRTQGQKTPPPDPVGTYNPACALALNEAKRLLVESKDTLVEMAKNEVDVREQQLQISDRVCASLAQKASETLELKERLNMTLGLMRGTILRCTKYNQELYTTHGLIKGPLSKVHLETAEKLDRPLVRMYQRHVGTQLPEAARLAQGTDKLQCHITYLEKNLDELLATHKNLSWGLNCKNIGHEVDGNVVRLRLRQRQPHVCYEQAQRLVKDWDPRTPPPRSKSSADP", "length": 499 }, "evidence": [ { "id": "Q2YDN4", "url": "https://omabrowser.org/oma/group/Q2YDN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D4K7-1", "protein_name": "Tektin-like protein 1", "gene_name": "Tektl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVLLPSTDPGQDSRVGAPEWRQAAKATSRKAHLLTDRCGQEAVTMWQPKDSVLDPNVAHHLGRAAYMEPWRFRVEMLKGGGTLEKPPPGEGVTLWKGKMKPPAWYARLPLPMHRDARAQQTAEVVHAHARGARLTAARLGRAQHQINGQLRLLLRQREATDRRLSEVRKGLLINQQSVKLRGYRPKCEKIPDKADSLLVWEKKELKSMKRKMEKDMEISEDLLKALASCRDTLDFYCQERLQAVELMNQPLDKVLEQAGRHSWVDITRPPTPRTQGLKTPPPDPIGTYTPACAKALFEAKRLLMESKDILTEMAKNEVDIQNQQQEISNRVCSSLAQKMRETLELKERMTMTLGLMRGTIHRCMKFNQEMYVTRGIIKGPLLKRNLEAREKLNRPLVRMYQRHVGTQLPEATRLAQGTDLLTRHNLHMEKNLKELRTTHDNLAWGLNCKKIGHDVDYDVVRLRLRQRHPHVCYEQAQRLVNDWDPPTPARSQTNTASK", "length": 499 }, "evidence": [ { "id": "Q2YDN4", "url": "https://omabrowser.org/oma/group/Q2YDN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "pmid": "" }, { "name": "axonemal B tubule inner sheath", "id": "GO:0160112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160112", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN4", "url": "https://www.uniprot.org/uniprotkb/Q2YDN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 500, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 372 ], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32KL4-1", "uniprot_ac": "Q32KL4", "uniprot_id": "RMD1_BOVIN", "mass": { "chemical_mass": 35923.0, "monoisotopic_mass": 35923.0 }, "refseq": { "ac": "NP_001032689", "name": "regulator of microtubule dynamics protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" }, "gene_names": [ { "name": "RMDN1", "type": "recommended", "evidence": [ { "id": "Q32KL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ] }, { "name": "FAM82B", "type": "synonym", "evidence": [ { "id": "NP_001032689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" }, { "id": "Q32KL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ] }, { "name": "RMDN1", "type": "synonym", "evidence": [ { "id": "NP_001032689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" } ] } ], "protein_names": [ { "name": "Regulator of microtubule dynamics protein 1", "type": "recommended", "evidence": [ { "id": "Q32KL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL4/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM82B", "type": "synonym", "evidence": [ { "id": "Q32KL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL4/entry#names_and_taxonomy" } ] }, { "name": "RMD-1", "type": "synonym", "evidence": [ { "id": "NP_001032689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" }, { "id": "Q32KL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL4/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 82, member B", "type": "synonym", "evidence": [ { "id": "NP_001032689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" } ] }, { "name": "regulator of microtubule dynamics protein 1", "type": "synonym", "evidence": [ { "id": "NP_001032689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RMDN1", "url": "https://www.uniprot.org/uniprotkb/Q32KL4", "locus": {} } ], "crossref": [ { "id": "Q32KL4", "url": "https://alphafold.ebi.ac.uk/entry/Q32KL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513788", "url": "https://www.ncbi.nlm.nih.gov/gene/513788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513788", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513788", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HILGVWH", "url": "https://omabrowser.org/oma/group/HILGVWH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KL4", "url": "https://www.orthodb.org/?gene=Q32KL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16056:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16056:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21033", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21033", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032689", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KL4-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALAVRFWCLFPVGRSAAWGLRLPAGAAGSRGQRVPWRLGASEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 317, "header": "sp|Q32KL4-1|RMD1_BOVIN Isoform 1 of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=2 SV=1 CANONICAL=Q32KL4-1" }, "isoforms": [ { "isoform_ac": "Q32KL4-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL4/entry#Q32KL4-1", "sequence": { "sequence": "MALAVRFWCLFPVGRSAAWGLRLPAGAAGSRGQRVPWRLGASEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 317, "header": "sp|Q32KL4-1|RMD1_BOVIN Isoform 1 of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=2 SV=1 CANONICAL=Q32KL4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513788", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513788", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q32KL4", "url": "https://www.uniprot.org/uniprotkb/Q32KL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KL4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KL5-1", "uniprot_ac": "Q32KL5", "uniprot_id": "EMC8_BOVIN", "mass": { "chemical_mass": 23777.0, "monoisotopic_mass": 23777.0 }, "refseq": { "ac": "NP_001033163", "name": "ER membrane protein complex subunit 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" }, "gene_names": [ { "name": "EMC8", "type": "recommended", "evidence": [ { "id": "Q32KL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ] }, { "name": "COX4NB", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" }, { "id": "Q32KL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ] }, { "name": "EMC8", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" } ] }, { "name": "NOC4", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 8", "type": "recommended", "evidence": [ { "id": "Q32KL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL5/entry#names_and_taxonomy" } ] }, { "name": "COX4 neighbor", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" } ] }, { "name": "ER membrane protein complex subunit 8", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" } ] }, { "name": "Neighbor of COX4", "type": "synonym", "evidence": [ { "id": "Q32KL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL5/entry#names_and_taxonomy" } ] }, { "name": "neighbor of COX4", "type": "synonym", "evidence": [ { "id": "NP_001033163", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163" } ] } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5#function" }, { "database": "UniProtKB", "id": "O43402", "url": "https://www.uniprot.org/uniprotkb/O43402#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC8", "url": "https://www.uniprot.org/uniprotkb/Q32KL5", "locus": { "chromosome": "18", "start_pos": 11747957, "end_pos": 11759716, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016075", "url": "https://www.ensembl.org/id/ENSBTAG00000016075" } ] } } ], "crossref": [ { "id": "Q32KL5", "url": "https://alphafold.ebi.ac.uk/entry/Q32KL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08060", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08060", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510727", "url": "https://www.ncbi.nlm.nih.gov/gene/510727", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510727", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510727", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KL5", "url": "https://www.orthodb.org/?gene=Q32KL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12941", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12941", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12941:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12941:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03665", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03665", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033163", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KL5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGVKLTTQAYCKMVLHGAKYPHCAVDGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDNSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVVPTIHVYEHHENKWRCRDPHYDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC", "length": 210, "header": "sp|Q32KL5-1|EMC8_BOVIN Isoform 1 of ER membrane protein complex subunit 8 OS=Bos taurus OX=9913 GN=EMC8 PE=2 SV=1 CANONICAL=Q32KL5-1" }, "isoforms": [ { "isoform_ac": "Q32KL5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL5/entry#Q32KL5-1", "sequence": { "sequence": "MPGVKLTTQAYCKMVLHGAKYPHCAVDGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDNSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVVPTIHVYEHHENKWRCRDPHYDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC", "length": 210, "header": "sp|Q32KL5-1|EMC8_BOVIN Isoform 1 of ER membrane protein complex subunit 8 OS=Bos taurus OX=9913 GN=EMC8 PE=2 SV=1 CANONICAL=Q32KL5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510727", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510727", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "Q32KL5", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 210, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL5" }, { "id": "PRU01182", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01182" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MPN", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 150, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KL8-1", "uniprot_ac": "Q32KL8", "uniprot_id": "TBATA_BOVIN", "mass": { "chemical_mass": 37398.0, "monoisotopic_mass": 37398.0 }, "refseq": { "ac": "NP_001033210", "name": "protein TBATA", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" }, "gene_names": [ { "name": "TBATA", "type": "recommended", "evidence": [ { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ] }, { "name": "C28H10orf27", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] }, { "name": "SPATIAL", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" }, { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ] }, { "name": "TBATA", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] } ], "protein_names": [ { "name": "Protein TBATA", "type": "recommended", "evidence": [ { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8/entry#names_and_taxonomy" } ] }, { "name": "Protein SPATIAL", "type": "synonym", "evidence": [ { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8/entry#names_and_taxonomy" } ] }, { "name": "Stromal protein associated with thymii and lymph node homolog", "type": "synonym", "evidence": [ { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8/entry#names_and_taxonomy" } ] }, { "name": "Thymus, brain and testes-associated protein", "type": "synonym", "evidence": [ { "id": "Q32KL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL8/entry#names_and_taxonomy" } ] }, { "name": "protein SPATIAL", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] }, { "name": "protein TBATA", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] }, { "name": "stromal protein associated with thymii and lymph node homolog", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] }, { "name": "thymus, brain and testes-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001033210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210" } ] } ], "function": [ { "annotation": "May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.", "evidence": [ { "database": "UniProtKB", "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBATA", "url": "https://www.uniprot.org/uniprotkb/Q32KL8", "locus": { "chromosome": "28", "start_pos": 26937388, "end_pos": 26951865, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021180", "url": "https://www.ensembl.org/id/ENSBTAG00000021180" } ] } } ], "crossref": [ { "id": "Q32KL8", "url": "https://alphafold.ebi.ac.uk/entry/Q32KL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "515913", "url": "https://www.ncbi.nlm.nih.gov/gene/515913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KL8", "url": "https://www.orthodb.org/?gene=Q32KL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33772", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33772", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33772:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33772:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033210", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KL8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEVRAQLAERSLPSPKGELKLEKKSGCQPRSHGDSGPQKELMIPGIVDFKLIREAVRTSKPQTPSAYRFGRLSHHSFFSRHHPQPQHVTHIQDLTGKPVCVVRDELSLPTISVPVGDPQSNRDPRLYSEAWKKELKDLASRVAIFTKESELKSKEKEEPQREQGAKYSAETGRLIPASTWAMARRHSHQGRNQPASRDEGDQTFVLQDQELLILELLSQILQTDSLNAIQFWLLYAPAKEKDMALGLLQTAVAQLLPQPLVPIPAEKLLNQLLEVQDSLQERHQLPYSQSPKKMKTPPLSKSEKPENIGKAQVLRVHSSQNPEEKAAKAEG", "length": 333, "header": "sp|Q32KL8-1|TBATA_BOVIN Isoform 1 of Protein TBATA OS=Bos taurus OX=9913 GN=TBATA PE=2 SV=1 CANONICAL=Q32KL8-1" }, "isoforms": [ { "isoform_ac": "Q32KL8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KL8/entry#Q32KL8-1", "sequence": { "sequence": "MATEVRAQLAERSLPSPKGELKLEKKSGCQPRSHGDSGPQKELMIPGIVDFKLIREAVRTSKPQTPSAYRFGRLSHHSFFSRHHPQPQHVTHIQDLTGKPVCVVRDELSLPTISVPVGDPQSNRDPRLYSEAWKKELKDLASRVAIFTKESELKSKEKEEPQREQGAKYSAETGRLIPASTWAMARRHSHQGRNQPASRDEGDQTFVLQDQELLILELLSQILQTDSLNAIQFWLLYAPAKEKDMALGLLQTAVAQLLPQPLVPIPAEKLLNQLLEVQDSLQERHQLPYSQSPKKMKTPPLSKSEKPENIGKAQVLRVHSSQNPEEKAAKAEG", "length": 333, "header": "sp|Q32KL8-1|TBATA_BOVIN Isoform 1 of Protein TBATA OS=Bos taurus OX=9913 GN=TBATA PE=2 SV=1 CANONICAL=Q32KL8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515913", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32KL8", "url": "https://www.uniprot.org/uniprotkb/Q32KL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KL8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 333, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KL8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KL8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KM2-1", "uniprot_ac": "Q32KM2", "uniprot_id": "C10_BOVIN", "mass": { "chemical_mass": 13719.0, "monoisotopic_mass": 13719.0 }, "refseq": { "ac": "NP_001068993", "name": "protein C10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068993" }, "gene_names": [ { "name": "C5H12orf57", "type": "synonym", "evidence": [ { "id": "NP_001068993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068993" } ] } ], "protein_names": [ { "name": "Protein C10", "type": "recommended", "evidence": [ { "id": "Q32KM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KM2/entry#names_and_taxonomy" } ] }, { "name": "protein C10", "type": "synonym", "evidence": [ { "id": "NP_001068993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068993" } ] } ], "function": [ { "annotation": "In brain, may be required for corpus callosum development.", "evidence": [ { "database": "UniProtKB", "id": "Q32KM2", "url": "https://www.uniprot.org/uniprotkb/Q32KM2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KM2", "url": "https://www.uniprot.org/uniprotkb/Q32KM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q32KM2", "locus": {} } ], "crossref": [ { "id": "Q32KM2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "511545", "url": "https://www.ncbi.nlm.nih.gov/gene/511545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KM2", "url": "https://www.orthodb.org/?gene=Q32KM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13463", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13463", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13463:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13463:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14974", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14974", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KM2", "url": "https://www.uniprot.org/uniprotkb/Q32KM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KM2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASASAQSAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNACNDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKLKALFLPPMTLPPHGPASGGSVAASLGLALP", "length": 132, "header": "sp|Q32KM2-1|C10_BOVIN Isoform 1 of Protein C10 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KM2-1" }, "isoforms": [ { "isoform_ac": "Q32KM2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM2/entry#Q32KM2-1", "sequence": { "sequence": "MASASAQSAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNACNDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKLKALFLPPMTLPPHGPASGGSVAASLGLALP", "length": 132, "header": "sp|Q32KM2-1|C10_BOVIN Isoform 1 of Protein C10 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KM2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511545", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KM2", "url": "https://www.uniprot.org/uniprotkb/Q32KM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "post-embryonic development", "id": "GO:0009791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009791", "evidence": [ { "database": "UniProtKB", "id": "Q32KM2", "url": "https://www.uniprot.org/uniprotkb/Q32KM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KM2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 132, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KM2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KM2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KN0-1", "uniprot_ac": "Q32KN0", "uniprot_id": "ZN572_BOVIN", "mass": { "chemical_mass": 60371.0, "monoisotopic_mass": 60371.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF572", "type": "recommended", "evidence": [ { "id": "Q32KN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ] } ], "protein_names": [ { "name": "Zinc finger protein 572", "type": "recommended", "evidence": [ { "id": "Q32KN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF572", "url": "https://www.uniprot.org/uniprotkb/Q32KN0", "locus": { "chromosome": "14", "start_pos": 15178243, "end_pos": 15192599, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009072", "url": "https://www.ensembl.org/id/ENSBTAG00000009072" } ] } } ], "crossref": [ { "id": "Q32KN0", "url": "https://alphafold.ebi.ac.uk/entry/Q32KN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768004", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768004", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KN0", "url": "https://www.orthodb.org/?gene=Q32KN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQEQKLLVSDSNGLTKKESLKNTITGDESKNNLKTVQFSNSKADKERASKWSRSDGPENYKDEDTKEILLTGSQGGKTERDDSYENDSNLGSQRNCTEKEEEQPNHWGWSPGDHTGPAGQQNPSFGDKPYKCSECWKSFSNSSHLRIHQRTHSGEKPYRCSECGKCFSNSSHLIQHLRTHTGEKPYQCGECGKSFSNTSHLIIHERTHTGEKPYKCPECAKSLSSSSHLIQHHRSHTGEKPYECPLCGKCFSHSYVLVEHQRTHTGEKPYKCPDCGKSFSQSSSLIRHQRTHTGEKPYKCPECGKGFGCNSTLIKHQRIHTGEKPYQCIECGKNFSRSSNLVTHQKMHTDDKTYQSSEYEESLSQNYSLIEECRIQPGEKPYKCCECGKSFGLSSHLIRHQRTHTGEKPYRCSECWKTFSQSSTLVIHQRTHTGEKPYKCPDCGECFSQSFNLIRHRRTHMGEKPYKCTDCEKCFSRSAYLSQHRKIHVGKSFESPEVEDFPHEWTWKNYSGEIALIPSFSVPSSSPS", "length": 529, "header": "sp|Q32KN0-1|ZN572_BOVIN Isoform 1 of Zinc finger protein 572 OS=Bos taurus OX=9913 GN=ZNF572 PE=2 SV=1 CANONICAL=Q32KN0-1" }, "isoforms": [ { "isoform_ac": "Q32KN0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN0/entry#Q32KN0-1", "sequence": { "sequence": "MEQEQKLLVSDSNGLTKKESLKNTITGDESKNNLKTVQFSNSKADKERASKWSRSDGPENYKDEDTKEILLTGSQGGKTERDDSYENDSNLGSQRNCTEKEEEQPNHWGWSPGDHTGPAGQQNPSFGDKPYKCSECWKSFSNSSHLRIHQRTHSGEKPYRCSECGKCFSNSSHLIQHLRTHTGEKPYQCGECGKSFSNTSHLIIHERTHTGEKPYKCPECAKSLSSSSHLIQHHRSHTGEKPYECPLCGKCFSHSYVLVEHQRTHTGEKPYKCPDCGKSFSQSSSLIRHQRTHTGEKPYKCPECGKGFGCNSTLIKHQRIHTGEKPYQCIECGKNFSRSSNLVTHQKMHTDDKTYQSSEYEESLSQNYSLIEECRIQPGEKPYKCCECGKSFGLSSHLIRHQRTHTGEKPYRCSECWKTFSQSSTLVIHQRTHTGEKPYKCPDCGECFSQSFNLIRHRRTHMGEKPYKCTDCEKCFSRSAYLSQHRKIHVGKSFESPEVEDFPHEWTWKNYSGEIALIPSFSVPSSSPS", "length": 529, "header": "sp|Q32KN0-1|ZN572_BOVIN Isoform 1 of Zinc finger protein 572 OS=Bos taurus OX=9913 GN=ZNF572 PE=2 SV=1 CANONICAL=Q32KN0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768004", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768004", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q32KN0", "url": "https://www.uniprot.org/uniprotkb/Q32KN0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KN0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 529, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KN0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KN0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 170, "end_pos": 172 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 335, "end_pos": 337 }, { "start_pos": 367, "end_pos": 369 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 87, "end_pos": 89 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KP2-1", "uniprot_ac": "Q32KP2", "uniprot_id": "LRC23_BOVIN", "mass": { "chemical_mass": 39588.0, "monoisotopic_mass": 39588.0 }, "refseq": { "ac": "NP_001033288", "name": "leucine-rich repeat-containing protein 23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033288" }, "gene_names": [ { "name": "LRRC23", "type": "recommended", "evidence": [ { "id": "Q32KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ] }, { "name": "LRRC23", "type": "synonym", "evidence": [ { "id": "NP_001033288", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033288" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 23", "type": "recommended", "evidence": [ { "id": "Q32KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP2/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 23", "type": "synonym", "evidence": [ { "id": "NP_001033288", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033288" } ] } ], "function": [ { "annotation": "Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella.", "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2#function" }, { "database": "UniProtKB", "id": "Q53EV4", "url": "https://www.uniprot.org/uniprotkb/Q53EV4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC23", "url": "https://www.uniprot.org/uniprotkb/Q32KP2", "locus": { "chromosome": "5", "start_pos": 103546873, "end_pos": 103554354, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011273", "url": "https://www.ensembl.org/id/ENSBTAG00000011273" } ] } } ], "crossref": [ { "id": "Q32KP2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "613700", "url": "https://www.ncbi.nlm.nih.gov/gene/613700", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613700", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613700", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KP2", "url": "https://www.orthodb.org/?gene=Q32KP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033288", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KP2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDEDDLEDFETDQDDLEREDDEKETEEWEDYRKEGEESEDWISTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEIKDRDLTDIHLLRSYIHLRYVDVSENHLTDLSPLNHLTNLLWLKADGNQLRSARLNELPYLQIASFAYNQITDTEGISHPRLASLDLKGNRIHMVTGLDPQKLISLHTLELRGNQLNSTLGINLPKLKNLFLAQNMLKKVEGLENLSNLTTLHLRDNQIETLSGFSKEMKSLQYLNLRGNMVADLGELAKLRDLPRLRALVLLDNPCTDENDYRQEALVQIAHLERLDKEFYEEEERAEADEIRQRMKEEQEQEAEVEPESELDQSST", "length": 342, "header": "sp|Q32KP2-1|LRC23_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 23 OS=Bos taurus OX=9913 GN=LRRC23 PE=1 SV=1 CANONICAL=Q32KP2-1" }, "isoforms": [ { "isoform_ac": "Q32KP2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP2/entry#Q32KP2-1", "sequence": { "sequence": "MSDEDDLEDFETDQDDLEREDDEKETEEWEDYRKEGEESEDWISTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEIKDRDLTDIHLLRSYIHLRYVDVSENHLTDLSPLNHLTNLLWLKADGNQLRSARLNELPYLQIASFAYNQITDTEGISHPRLASLDLKGNRIHMVTGLDPQKLISLHTLELRGNQLNSTLGINLPKLKNLFLAQNMLKKVEGLENLSNLTTLHLRDNQIETLSGFSKEMKSLQYLNLRGNMVADLGELAKLRDLPRLRALVLLDNPCTDENDYRQEALVQIAHLERLDKEFYEEEERAEADEIRQRMKEEQEQEAEVEPESELDQSST", "length": 342, "header": "sp|Q32KP2-1|LRC23_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 23 OS=Bos taurus OX=9913 GN=LRRC23 PE=1 SV=1 CANONICAL=Q32KP2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613700", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613700", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ], "pmid": "" }, { "name": "radial spoke assembly", "id": "GO:0062177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062177", "evidence": [ { "database": "UniProtKB", "id": "Q32KP2", "url": "https://www.uniprot.org/uniprotkb/Q32KP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KP2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 342, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KP2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KP2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 }, { "start_pos": 219, "end_pos": 221 }, { "start_pos": 222, "end_pos": 224 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KP7-1", "uniprot_ac": "Q32KP7", "uniprot_id": "CHCT1_BOVIN", "mass": { "chemical_mass": 27384.0, "monoisotopic_mass": 27384.0 }, "refseq": { "ac": "NP_001069397", "name": "CHD1 helical C-terminal domain containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" }, "gene_names": [ { "name": "CHCT1", "type": "recommended", "evidence": [ { "id": "Q32KP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP7" } ] }, { "name": "C17orf64", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] }, { "name": "C19H17orf64", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] }, { "name": "CHCT1", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] } ], "protein_names": [ { "name": "CHD1 helical C-terminal domain containing protein 1", "type": "recommended", "evidence": [ { "id": "Q32KP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP7/entry#names_and_taxonomy" } ] }, { "name": "CHD1 helical C-terminal domain containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] }, { "name": "Uncharacterized protein C17orf64 homolog", "type": "synonym", "evidence": [ { "id": "Q32KP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP7/entry#names_and_taxonomy" } ] }, { "name": "chromosome 19 C17orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] }, { "name": "uncharacterized protein C17orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397" } ] } ], "function": [ { "annotation": "May play a role in regulation of apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "Q32KP7", "url": "https://www.uniprot.org/uniprotkb/Q32KP7#function" }, { "database": "UniProtKB", "id": "Q9D979", "url": "https://www.uniprot.org/uniprotkb/Q9D979#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KP7", "url": "https://www.uniprot.org/uniprotkb/Q32KP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHCT1", "url": "https://www.uniprot.org/uniprotkb/Q32KP7", "locus": { "chromosome": "19", "start_pos": 12521668, "end_pos": 12532887, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018391", "url": "https://www.ensembl.org/id/ENSBTAG00000018391" } ] } } ], "crossref": [ { "id": "Q32KP7", "url": "https://alphafold.ebi.ac.uk/entry/Q32KP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018391", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018391", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530096", "url": "https://www.ncbi.nlm.nih.gov/gene/530096", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025260", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025260", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530096", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530096", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FLQHCCR", "url": "https://omabrowser.org/oma/group/FLQHCCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KP7", "url": "https://www.orthodb.org/?gene=Q32KP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069397", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KP7", "url": "https://www.uniprot.org/uniprotkb/Q32KP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KP7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEASDGQADEREEPLEQGTNARSLERRSSTTPAKDSLVRHAKGLDRDTFKICKEYLRPLKKFLRKLHLPKDLPQKKKLKYMKQSLVVLGDHINTFLQHYCRAWEIKHWKKMLWRFVSLFSELEAKQLRKLYKYTKNNQTTKFLMAFCPLDAPESSLLADQEDSLPKLCTAWGLRSHLNGMKERLSKLQAPGHPARLLKELRARGPRRRGSKLPQEPKLKRRRIKEAPDTPETCL", "length": 234, "header": "sp|Q32KP7-1|CHCT1_BOVIN Isoform 1 of CHD1 helical C-terminal domain containing protein 1 OS=Bos taurus OX=9913 GN=CHCT1 PE=2 SV=2 CANONICAL=Q32KP7-1" }, "isoforms": [ { "isoform_ac": "Q32KP7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP7/entry#Q32KP7-1", "sequence": { "sequence": "MEASDGQADEREEPLEQGTNARSLERRSSTTPAKDSLVRHAKGLDRDTFKICKEYLRPLKKFLRKLHLPKDLPQKKKLKYMKQSLVVLGDHINTFLQHYCRAWEIKHWKKMLWRFVSLFSELEAKQLRKLYKYTKNNQTTKFLMAFCPLDAPESSLLADQEDSLPKLCTAWGLRSHLNGMKERLSKLQAPGHPARLLKELRARGPRRRGSKLPQEPKLKRRRIKEAPDTPETCL", "length": 234, "header": "sp|Q32KP7-1|CHCT1_BOVIN Isoform 1 of CHD1 helical C-terminal domain containing protein 1 OS=Bos taurus OX=9913 GN=CHCT1 PE=2 SV=2 CANONICAL=Q32KP7-1" }, "locus": { "chromosome": "19", "start_pos": 12532887, "end_pos": 12521848, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054304.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054304.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047980.2", "url": "https://www.ensembl.org/id/ENSBTAP00000047980.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530096", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530096", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A8L7-1", "protein_name": "CHD1 helical C-terminal domain containing 1", "gene_name": "Chct1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEASDWQVGEGDKPLEKVGSVPCLERSSSTVPAGDVLVRHAKGLSQDTFKICKEYLRPLKKFLRKLNLPKDLPQKKRIKYTKQSLEALGDHINTFLQHYCRAWEIKHWKKMLWRFVSLFSELEAKQLRRLYKYTKTNQTAKFLVALCPLDAPERSLLANQEDSLPRLCSAWGLHGNISGMKERLSKMQAPGQEAILLDESRSSHCSRDSLMKLPQKPKLKKKRIKERPESPKSYS", "length": 235 }, "evidence": [ { "id": "Q32KP7", "url": "https://omabrowser.org/oma/group/Q32KP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86WR6-1", "protein_name": "CHD1 helical C-terminal domain containing protein 1", "gene_name": "CHCT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEASDGQGGEGDKPLEQVTNVSCLETSSSASPARDSLMRHAKGLDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVTFCASDAPERSLLADREDSLPKLCHAWGLHSNISGMKERLSNMQTPGQGSPLPGQPRSQDHVKKDSLRELSQKPKLKRKRIKEAPETPETEP", "length": 236 }, "evidence": [ { "id": "Q32KP7", "url": "https://omabrowser.org/oma/group/Q32KP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D979-1", "protein_name": "CHD1 helical C-terminal domain containing protein 1", "gene_name": "Chct1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASDWQGGEGDKPLEKVGSVPCLERSSSTVPTGDALVRHAKGLSQDTFKICKEYLRPLKKFLRKLNLPKDLPQKKRIKYTKQSLEALGGHINTFLQHYCRAWEIKHWKKMLWRFVSLFSELEAKQLRRLYKYTKTNQTAKFLAALCPLDAPERSLLANQEDCLPRLCSAWGLHGNISGMKERLSKMQAPGQEVVMLEEPRSSHCSRGDSLRKLPQKPKLKKKRIKERLESPKSCS", "length": 236 }, "evidence": [ { "id": "Q32KP7", "url": "https://omabrowser.org/oma/group/Q32KP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KP7", "url": "https://www.uniprot.org/uniprotkb/Q32KP7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KP7", "url": "https://www.uniprot.org/uniprotkb/Q32KP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KP7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KQ2-1", "uniprot_ac": "Q32KQ2", "uniprot_id": "WDR53_BOVIN", "mass": { "chemical_mass": 39242.0, "monoisotopic_mass": 39242.0 }, "refseq": { "ac": "NP_001069240", "name": "WD repeat-containing protein 53", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069240" }, "gene_names": [ { "name": "WDR53", "type": "recommended", "evidence": [ { "id": "Q32KQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2" } ] }, { "name": "WDR53", "type": "synonym", "evidence": [ { "id": "NP_001069240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069240" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 53", "type": "recommended", "evidence": [ { "id": "Q32KQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 53", "type": "synonym", "evidence": [ { "id": "NP_001069240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069240" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KQ2", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR53", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2", "locus": { "chromosome": "1", "start_pos": 71087882, "end_pos": 71100728, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014660", "url": "https://www.ensembl.org/id/ENSBTAG00000014660" } ] } } ], "crossref": [ { "id": "Q32KQ2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014660", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014660", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518441", "url": "https://www.ncbi.nlm.nih.gov/gene/518441", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518441", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518441", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDLMVWG", "url": "https://omabrowser.org/oma/group/GDLMVWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KQ2", "url": "https://www.orthodb.org/?gene=Q32KQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44666", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44666", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44666:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44666:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069240", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KQ2", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVKWTGGHSSPILCLNASQEGLVASGAEGGDLVVWGEDGTLLGHTCFQGAEDVTNVLFSPSCPTKLYASHGETISILDVRSLKEPLDDFHVNEEEINCLSLNETENLLASADDSGTIKILDLENKKISRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWNLRKARPLWITNLQEDETEEMESPQSPGQLLNPALAHSVSVASCGNVFSCGAEDGKVRIFRVMGVKCEQELGFKGHSLGVSQVCFLRESYLLLTGGNDGKIKLWDVSSEIEKKHKSPTKHTHRKKTKRAAYTKQGGGTHASVTGEDEHGKILPKLSIEHGEKVNWLLSTKIKGYRNILVADQTSCISVYPLKEF", "length": 358, "header": "sp|Q32KQ2-1|WDR53_BOVIN Isoform 1 of WD repeat-containing protein 53 OS=Bos taurus OX=9913 GN=WDR53 PE=2 SV=1 CANONICAL=Q32KQ2-1" }, "isoforms": [ { "isoform_ac": "Q32KQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ2/entry#Q32KQ2-1", "sequence": { "sequence": "MAVKWTGGHSSPILCLNASQEGLVASGAEGGDLVVWGEDGTLLGHTCFQGAEDVTNVLFSPSCPTKLYASHGETISILDVRSLKEPLDDFHVNEEEINCLSLNETENLLASADDSGTIKILDLENKKISRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWNLRKARPLWITNLQEDETEEMESPQSPGQLLNPALAHSVSVASCGNVFSCGAEDGKVRIFRVMGVKCEQELGFKGHSLGVSQVCFLRESYLLLTGGNDGKIKLWDVSSEIEKKHKSPTKHTHRKKTKRAAYTKQGGGTHASVTGEDEHGKILPKLSIEHGEKVNWLLSTKIKGYRNILVADQTSCISVYPLKEF", "length": 358, "header": "sp|Q32KQ2-1|WDR53_BOVIN Isoform 1 of WD repeat-containing protein 53 OS=Bos taurus OX=9913 GN=WDR53 PE=2 SV=1 CANONICAL=Q32KQ2-1" }, "locus": { "chromosome": "1", "start_pos": 71092835, "end_pos": 71088060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019520.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019520.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019520.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019520.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518441", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518441", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZVA2-1", "protein_name": "WD repeat domain 53", "gene_name": "WDR53", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVKWTGGHSSPILCLNASQEGLVASGAEGGDLTVWGEDGTPLGHTCFQGADDVTSVLFSPSCPTKLYASHGETISILDVRSLKGSLDHFHVNEEEINCLSLNETENLLASADDSGTIKILDLENKKVSRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWNLQKARPLWITNLQEDEAEEMESPQSPGQLLNPALAHSVSVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTLGISQVCFLPGSYLLLTGGNDGKIMLWDISSEVEKKQKSPAKHTHRKKTKRAIGNKQGRNTHASVTGEDEHGKILPKLSLEHGEKVNWLLGTKIKGYQNILVADQTNCISVYPLKEF", "length": 358 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZZZ2-1", "protein_name": "WD repeat domain 53", "gene_name": "WDR53", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRGVGVPAERSGPAPTAMAVRWEGGHSASVLCLAAGREGLVASGAERGELALWGREGVPAGRLRLSPAEDDVAALAFSPRLPHRLYAAHGAAVALLDVRALREPVERLRFNEEEIGCLALSDAGALLAAADDSGAVKVVDLESKKVVRSLRHANICSSVAFRPQRPQSLVSCGLDMQVMLWNLQKARPLWTTNLQECGTEEDSLQSAGQLFNPPLAHSLSVASCGNVFGCGAQDGKVRIFRVTGLKFERELEFRGHSLGVSQVLFMPESYCLLTGGNDGKVLLWDVSNDIGKQQKSPAKSLHKRKGQAAATARKDGKLNKVASNEHARILPKLTIEHGEKVNWITCAEIKGSRRVLVADQSSSISVYPLPES", "length": 372 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FX19-1", "protein_name": "WD repeat-containing protein 53 isoform X2", "gene_name": "Wdr53", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGLEAAGEVITRRRPRTGRPVLQPIMAVKWTGGHSSSILCLNASKDGLVASGAEGGDLVAWGEDGTLLGRMQLEGADDVTSILFSPSCPTKLYASHGETISVLDIRSLKESVDRFHVNDEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPVWITNLQEDETEEMEGPQSPGQLLNPALAHSVSVASCGNIFSCGAEDGKVRIFRVMGVKCERELGFKGHALGVSQVCFLTESHLLLTGGNDGKIRLWNVSSEMEKKQKSPAKHTHRKKAKRAACPKQGRDSSTTGADEEEHAKVLPKLDIEHGEKVNWLLSSKIKGHQSILVADQTSCVSVYPLNEL", "length": 383 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F4KEM4-1", "protein_name": "Transducin/WD40 repeat-like superfamily protein", "gene_name": "MRA19.19", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATAMEEPRKLRGHKSTATCCIASRDRPGIVLTSGEDGCICWFDLRCKDVQFIIDVGTEPVSSLCFKTGNENILYASCGNEIKSFDVHTLSATSWKPLESYNYNKDEVNQVVCNGRSSFLASADDSGDVKIIDLGQKCLYKTLRAGHTSICSSVQFIPWRPWEVITGGLDSKLVLWDFSKGRSQKIIDFGSDTNNNSGQCLNPAFVHSIAIPEMDMVDKLDKICAVARGDGIVNLINIESELSRKGTSSKGSSSSSSNNVVKRVCLDYSVGGHNSAVSCVAFSLFQEKGRFLISGGNDKTVKIWDCFKCLDPNNNNNNSDLLHLNINLSKKVNWLCTNQSDSENLVVCDTTRVVKVYSIS", "length": 360 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54BI5-1", "protein_name": "WD repeat-containing protein 53 homolog", "gene_name": "wdr53", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTSVDINNNNNNNNNSNSNIIETKLIGHKDTVLCISSHNKKEIIASGSDDCTVRIWDLNTNKSIQSIVEGFQGNPVNNVCFDQDFTLYCSYDNIIVSFDLRQPNVILKEFNTQYKFNTEEINQLSFDSKYQYLAACDDSGQTKIIDVTKNKLVESLNKKHTNIATGCVFRPNSKNELITSSMDFSIIHWDFLKAKVLHRDTFKEGSLPQNISKSQQQQQETTEPNRMLNPPFVTSVDCSNNSKYVAISMGDGTIVINEISSFKQYLKINSIHKSSIQQVHYPKYLENNYQRLISFGNYDKKIVIWDVSEDMNTKVSSSLLSNDEKNNERIKTWLEHSEKINCLTTSNLKNNAIFVADLSNDLKLLSIQ", "length": 368 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7Z5U6-1", "protein_name": "WD repeat-containing protein 53", "gene_name": "WDR53", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF", "length": 358 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DB94-1", "protein_name": "WD repeat-containing protein 53", "gene_name": "Wdr53", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVKWTGGHSSSILCLNANKDGLVASGGEGGDLVAWGEDGTPLGHMQLEGADDVTSVLFSASCPTKLYASHGETISVLDVRSLKGSLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPVWITNLQEDETEETEGPQTPGRLLNPALAHSVSVASCGNIFSCGAEDGKVRIFRVMGVKCERELGFKGHTLGVSQVCFLPESSLLLTGGNDGRIRLWDVSGKMEKLQKSPARHIHRKKAKRAACPTQGGNSRAPGAEDEGHAKILPKLDIEHGEKVNWLLSTKIKGNKSILVADQTSCVSVYPLNEL", "length": 358 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "X1WBQ1-1", "protein_name": "WD repeat-containing protein 53", "gene_name": "wdr53", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSCVWTGGHGTSILCAGVSCESESLVATGAEGGELTLWSHDGSPVSKLRMSADDDVTCVAFSPSAPCMLYASYGRTVAVLDSRNLKSAVAELADAGEEEINCVSVNEAGGALAAADDSGAVRIIDLQQEKVVRTLRKHDNICSSVTFRPHRPQSLVSAGLDMQVSLWNLPKVRPLWTYSLQDTQEEDAHPQKAGQMFNPPLAHCIDVTSCGDVFACAAEDGYVHLLRVSEDSRLRERAMFKAHSQGASQARFINFLSQPYWLATGGNDGLVALWDISREDVLARKSKGHKRRQKGRAKKKPEAQATHTKSEEEEASSSSCSSETAGGKNEPKLTFQHGEKVNWICPAVLKGKKSLLVTDQRPSPTVYSLDQL", "length": 372 }, "evidence": [ { "id": "Q32KQ2", "url": "https://omabrowser.org/oma/group/Q32KQ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KQ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KQ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KQ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KQ5-1", "uniprot_ac": "Q32KQ5", "uniprot_id": "TM225_BOVIN", "mass": { "chemical_mass": 26224.0, "monoisotopic_mass": 26224.0 }, "refseq": { "ac": "NP_001073753", "name": "transmembrane protein 225", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753" }, "gene_names": [ { "name": "TMEM225", "type": "recommended", "evidence": [ { "id": "Q32KQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5" } ] }, { "name": "PMP22CD", "type": "synonym", "evidence": [ { "id": "NP_001073753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753" }, { "id": "Q32KQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5" } ] }, { "name": "TMEM225", "type": "synonym", "evidence": [ { "id": "NP_001073753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753" } ] } ], "protein_names": [ { "name": "Transmembrane protein 225", "type": "recommended", "evidence": [ { "id": "Q32KQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5/entry#names_and_taxonomy" } ] }, { "name": "PMP22 claudin domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001073753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753" } ] }, { "name": "transmembrane protein 225", "type": "synonym", "evidence": [ { "id": "NP_001073753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753" } ] } ], "function": [ { "annotation": "Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ5", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5#function" }, { "database": "UniProtKB", "id": "Q9D9S2", "url": "https://www.uniprot.org/uniprotkb/Q9D9S2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KQ5", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM225", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5", "locus": { "chromosome": "29", "start_pos": 27192754, "end_pos": 27196074, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033502", "url": "https://www.ensembl.org/id/ENSBTAG00000033502" } ] } } ], "crossref": [ { "id": "Q32KQ5", "url": "https://alphafold.ebi.ac.uk/entry/Q32KQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "519985", "url": "https://www.ncbi.nlm.nih.gov/gene/519985", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057351", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057351", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519985", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519985", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KQ5", "url": "https://www.orthodb.org/?gene=Q32KQ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36477", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36477", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36477:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36477:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KQ5", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHILVRKVEATNMFFSSWTLVFLAVGIIIEEWAELKLGPQKPTITHSPWICCTPLWPSDGLEVIRNILIVVLSLSFMHNLLLGFEFTYMIPQTKYTLIMTACLAFLTGILLLGALLLYHHMLRQGESVYYSSYKISWIIFTAYLNVLFLFISGFLSLLQYKQPIDGSGSLIPRSARKSQVMEQHGVSIKVVSLPAGTAMPRSIVRLHSAHMKEDSPERLNIQARRVTWAL", "length": 231, "header": "sp|Q32KQ5-1|TM225_BOVIN Isoform 1 of Transmembrane protein 225 OS=Bos taurus OX=9913 GN=TMEM225 PE=2 SV=2 CANONICAL=Q32KQ5-1" }, "isoforms": [ { "isoform_ac": "Q32KQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5/entry#Q32KQ5-1", "sequence": { "sequence": "MVHILVRKVEATNMFFSSWTLVFLAVGIIIEEWAELKLGPQKPTITHSPWICCTPLWPSDGLEVIRNILIVVLSLSFMHNLLLGFEFTYMIPQTKYTLIMTACLAFLTGILLLGALLLYHHMLRQGESVYYSSYKISWIIFTAYLNVLFLFISGFLSLLQYKQPIDGSGSLIPRSARKSQVMEQHGVSIKVVSLPAGTAMPRSIVRLHSAHMKEDSPERLNIQARRVTWAL", "length": 231, "header": "sp|Q32KQ5-1|TM225_BOVIN Isoform 1 of Transmembrane protein 225 OS=Bos taurus OX=9913 GN=TMEM225 PE=2 SV=2 CANONICAL=Q32KQ5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519985", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal membrane", "id": "GO:0002080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002080", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ5", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KQ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 231, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KQ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KQ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ5" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "RVxF", "eco_id": "ECO_0000250", "start_pos": 225, "end_pos": 229, "start_aa": "Arg", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KQ7-1", "uniprot_ac": "Q32KQ7", "uniprot_id": "CSTP1_BOVIN", "mass": { "chemical_mass": 37423.0, "monoisotopic_mass": 37423.0 }, "refseq": { "ac": "NP_001033126", "name": "centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" }, "gene_names": [ { "name": "CSTPP1", "type": "recommended", "evidence": [ { "id": "Q32KQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7" } ] }, { "name": "C11orf49", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] }, { "name": "C15H11orf49", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] }, { "name": "CSTPP1", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] } ], "protein_names": [ { "name": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "type": "recommended", "evidence": [ { "id": "Q32KQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7/entry#names_and_taxonomy" } ] }, { "name": "UPF0705 protein C11orf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] }, { "name": "centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] }, { "name": "chromosome 15 C11orf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126" } ] } ], "function": [ { "annotation": "Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ7", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7#function" }, { "database": "UniProtKB", "id": "Q9H6J7", "url": "https://www.uniprot.org/uniprotkb/Q9H6J7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KQ7", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSTPP1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7", "locus": { "chromosome": "15", "start_pos": 77063224, "end_pos": 76852584, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009573", "url": "https://www.ensembl.org/id/ENSBTAG00000009573" } ] } } ], "crossref": [ { "id": "Q32KQ7", "url": "https://alphafold.ebi.ac.uk/entry/Q32KQ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505437", "url": "https://www.ncbi.nlm.nih.gov/gene/505437", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505437", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505437", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KQ7", "url": "https://www.orthodb.org/?gene=Q32KQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34252:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34252:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27900", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27900", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033126", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KQ7", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KQ7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSPERLALPDYEYLAQRHVLTYVEDAVCQLLENKEDISQYGIARFFTEYFNSVCQGTHILFREFSFIQATPHNRASFLRAFWRCFRTVGKNGDLLTMREYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLESVAAIYQDLLSGKNPNTVIVPTSSSGQHRHRPSTGEAGTPEGVEASLFYQCLENLCDRHKYSCPPPALVKEVLSNVQRLTFYGFLVALSKHHGINQALGALPDKGDLMHDPAMDEELERLVLRWRPHRSSRQHRAKEPGAFGYQRRDKLEALQTVPPASAPTPCLYQWEPIE", "length": 326, "header": "sp|Q32KQ7-1|CSTP1_BOVIN Isoform 1 of Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 OS=Bos taurus OX=9913 GN=CSTPP1 PE=2 SV=1 CANONICAL=Q32KQ7-1" }, "isoforms": [ { "isoform_ac": "Q32KQ7-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7/entry#Q32KQ7-1", "sequence": { "sequence": "MLSPERLALPDYEYLAQRHVLTYVEDAVCQLLENKEDISQYGIARFFTEYFNSVCQGTHILFREFSFIQATPHNRASFLRAFWRCFRTVGKNGDLLTMREYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLESVAAIYQDLLSGKNPNTVIVPTSSSGQHRHRPSTGEAGTPEGVEASLFYQCLENLCDRHKYSCPPPALVKEVLSNVQRLTFYGFLVALSKHHGINQALGALPDKGDLMHDPAMDEELERLVLRWRPHRSSRQHRAKEPGAFGYQRRDKLEALQTVPPASAPTPCLYQWEPIE", "length": 326, "header": "sp|Q32KQ7-1|CSTP1_BOVIN Isoform 1 of Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 OS=Bos taurus OX=9913 GN=CSTPP1 PE=2 SV=1 CANONICAL=Q32KQ7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 176, "start_aa": "Thr", "end_pos": 176, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr176", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 316, "start_aa": "Thr", "end_pos": 316, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr316", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505437", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505437", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ7", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ7", "url": "https://www.uniprot.org/uniprotkb/Q32KQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KQ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KQ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KQ7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 176, 316 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KQ9-1", "uniprot_ac": "Q32KQ9", "uniprot_id": "CST16_BOVIN", "mass": { "chemical_mass": 14688.0, "monoisotopic_mass": 14688.0 }, "refseq": { "ac": "NP_001033211", "name": "probable cystatin-16 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033211" }, "gene_names": [ { "name": "MGC133636", "type": "synonym", "evidence": [ { "id": "NP_001033211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033211" } ] } ], "protein_names": [ { "name": "Probable cystatin-16", "type": "recommended", "evidence": [ { "id": "Q32KQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9/entry#names_and_taxonomy" } ] }, { "name": "probable cystatin-16 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033211" } ] }, { "name": "probable cystatin-16", "type": "synonym", "evidence": [ { "id": "NP_001033211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033211" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KQ9", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9", "locus": {} } ], "crossref": [ { "id": "Q32KQ9", "url": "https://alphafold.ebi.ac.uk/entry/Q32KQ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515992", "url": "https://www.ncbi.nlm.nih.gov/gene/515992", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515992", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515992", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KQ9", "url": "https://www.orthodb.org/?gene=Q32KQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033211", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KQ9", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLKATLLLGLAVLGMHVWAIQMEFVDISKDLDYFVVSVEFAVAWFNSDNTEEQAYKLLEVRRAQQKSWTMIYLMELDLGRTICKKHDEDIDNCPLQESPGERKVNCTFIVDSRPWFTQFTLLNST", "length": 126, "header": "sp|Q32KQ9-1|CST16_BOVIN Isoform 1 of Probable cystatin-16 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KQ9-1" }, "isoforms": [ { "isoform_ac": "Q32KQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9/entry#Q32KQ9-1", "sequence": { "sequence": "MFLKATLLLGLAVLGMHVWAIQMEFVDISKDLDYFVVSVEFAVAWFNSDNTEEQAYKLLEVRRAQQKSWTMIYLMELDLGRTICKKHDEDIDNCPLQESPGERKVNCTFIVDSRPWFTQFTLLNST", "length": 126, "header": "sp|Q32KQ9-1|CST16_BOVIN Isoform 1 of Probable cystatin-16 OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KQ9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 106, "start_aa": "Asn", "end_pos": 106, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn106", "evidence": [ { "id": "Q32KQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515992", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515992", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ9", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "Q32KQ9", "url": "https://www.uniprot.org/uniprotkb/Q32KQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KQ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 126, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KQ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KQ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 106 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 124, "end_pos": 126 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KT0-1", "uniprot_ac": "Q32KT0", "uniprot_id": "CP087_BOVIN", "mass": { "chemical_mass": 17783.0, "monoisotopic_mass": 17783.0 }, "refseq": { "ac": "NP_001071513", "name": "UPF0547 protein C16orf87 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071513" }, "gene_names": [ { "name": "C18H16orf87", "type": "synonym", "evidence": [ { "id": "NP_001071513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071513" } ] } ], "protein_names": [ { "name": "UPF0547 protein C16orf87 homolog", "type": "recommended", "evidence": [ { "id": "Q32KT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KT0/entry#names_and_taxonomy" } ] }, { "name": "UPF0547 protein C16orf87 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071513" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KT0", "url": "https://www.uniprot.org/uniprotkb/Q32KT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q32KT0", "locus": {} } ], "crossref": [ { "id": "Q32KT0", "url": "https://alphafold.ebi.ac.uk/entry/Q32KT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003503", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003503", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614339", "url": "https://www.ncbi.nlm.nih.gov/gene/614339", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614339", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614339", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHVPVAC", "url": "https://omabrowser.org/oma/group/QHVPVAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KT0", "url": "https://www.orthodb.org/?gene=Q32KT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071513", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KT0", "url": "https://www.uniprot.org/uniprotkb/Q32KT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KT0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHPEKAPSSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 154, "header": "sp|Q32KT0-1|CP087_BOVIN Isoform 1 of UPF0547 protein C16orf87 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KT0-1" }, "isoforms": [ { "isoform_ac": "Q32KT0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KT0/entry#Q32KT0-1", "sequence": { "sequence": "MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHPEKAPSSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 154, "header": "sp|Q32KT0-1|CP087_BOVIN Isoform 1 of UPF0547 protein C16orf87 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32KT0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 91, "end_pos": 91, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KT0", "url": "https://www.uniprot.org/uniprotkb/Q32KT0" } ], "site_lbl": "Ser91" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614339", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614339", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6J5-1", "protein_name": "Chromosome 6 C16orf87 homolog", "gene_name": "C6H16orf87", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHPEKSSSTTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 154 }, "evidence": [ { "id": "Q32KT0", "url": "https://omabrowser.org/oma/group/Q32KT0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A288-1", "protein_name": "Similar to human chromosome 16 open reading frame 87", "gene_name": "C19h16orf87", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGRAQHHGSAHLCVGWWSLVGATPPSERSTALEGVAMGLPWKGRRLLLQPARSPAHAHARLHGRVAAGVRTRCVEQRSQGAASTAAQEGSMSATRAKKVKMATKSCPECDQQIPVACKSCPCGYIFISRKLLNAKHSEKSPPSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSSSAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 245 }, "evidence": [ { "id": "Q32KT0", "url": "https://omabrowser.org/oma/group/Q32KT0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZXE0-1", "protein_name": "C16orf87 homolog", "gene_name": "C16orf87", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNHCSCSHVEYVTAVLLLRKGSSVSSSGTWVSERRNGNEWEVPVACKSCPCGYIFISRKLLHAKRAERSPPITENKSEAKRRRTERVKREKINSAVNKDLENRKRSRSNSHSDHSRRGRGRPKSASAKKHEEEREKQEKEVDMYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 173 }, "evidence": [ { "id": "Q32KT0", "url": "https://omabrowser.org/oma/group/Q32KT0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6PH81-1", "protein_name": "UPF0547 protein C16orf87", "gene_name": "C16orf87", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHSEKSPPSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 154 }, "evidence": [ { "id": "Q32KT0", "url": "https://omabrowser.org/oma/group/Q32KT0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR55-1", "protein_name": "UPF0547 protein C16orf87 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSATRAKKVKMATKSCPECDQQIPVACKSCPCGYIFISRKLLNAKHSEKSPPSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSSSAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL", "length": 154 }, "evidence": [ { "id": "Q32KT0", "url": "https://omabrowser.org/oma/group/Q32KT0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KT0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KT0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KT0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 91 ], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KV8-1", "uniprot_ac": "Q32KV8", "uniprot_id": "ZN414_BOVIN", "mass": { "chemical_mass": 41094.0, "monoisotopic_mass": 41094.0 }, "refseq": { "ac": "NP_001033264", "name": "zinc finger protein 414", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033264" }, "gene_names": [ { "name": "ZNF414", "type": "recommended", "evidence": [ { "id": "Q32KV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ] }, { "name": "ZNF414", "type": "synonym", "evidence": [ { "id": "NP_001033264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033264" } ] } ], "protein_names": [ { "name": "Zinc finger protein 414", "type": "recommended", "evidence": [ { "id": "Q32KV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 414", "type": "synonym", "evidence": [ { "id": "NP_001033264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033264" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF414", "url": "https://www.uniprot.org/uniprotkb/Q32KV8", "locus": { "chromosome": "7", "start_pos": 17112595, "end_pos": 17116261, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007660", "url": "https://www.ensembl.org/id/ENSBTAG00000007660" } ] } } ], "crossref": [ { "id": "Q32KV8", "url": "https://alphafold.ebi.ac.uk/entry/Q32KV8", "database": "AlphaFoldDB", "categories": [] }, { "id": "538455", "url": "https://www.ncbi.nlm.nih.gov/gene/538455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538455", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538455", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KV8", "url": "https://www.orthodb.org/?gene=Q32KV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21695:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21695:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033264", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KV8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEEPSGPSLDMPATAEPSSSETDKGVSPVLAAIDKSSSMEEEPGPDRATTPPVWERGGPTGGTQQGASPAPDSGHSGPGHTLGPTSTVSGTSEDLRPTRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPKQSLEGKLFRCSALSCTETFPNMQELVAHGKLHYKPNRYFKCENCLLRIRTHRSLFKHLHVCAEHAQSPAPPPPPPALDRESPASERPPESDPAPAPGLPYPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGGSPRRPQGGSDAPSGHAAPSRIVWEHTRGRYSCMQCAFSTASRPAMTLHLEDHRPGGPAAPAPGQPRPDAPADPAPLAPKASPLLSEGECPVFSPL", "length": 391, "header": "sp|Q32KV8-1|ZN414_BOVIN Isoform 1 of Zinc finger protein 414 OS=Bos taurus OX=9913 GN=ZNF414 PE=2 SV=1 CANONICAL=Q32KV8-1" }, "isoforms": [ { "isoform_ac": "Q32KV8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KV8/entry#Q32KV8-1", "sequence": { "sequence": "MDEEPSGPSLDMPATAEPSSSETDKGVSPVLAAIDKSSSMEEEPGPDRATTPPVWERGGPTGGTQQGASPAPDSGHSGPGHTLGPTSTVSGTSEDLRPTRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPKQSLEGKLFRCSALSCTETFPNMQELVAHGKLHYKPNRYFKCENCLLRIRTHRSLFKHLHVCAEHAQSPAPPPPPPALDRESPASERPPESDPAPAPGLPYPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGGSPRRPQGGSDAPSGHAAPSRIVWEHTRGRYSCMQCAFSTASRPAMTLHLEDHRPGGPAAPAPGQPRPDAPADPAPLAPKASPLLSEGECPVFSPL", "length": 391, "header": "sp|Q32KV8-1|ZN414_BOVIN Isoform 1 of Zinc finger protein 414 OS=Bos taurus OX=9913 GN=ZNF414 PE=2 SV=1 CANONICAL=Q32KV8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 251, "start_aa": "Thr", "end_pos": 251, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr251", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 61, "start_aa": "Thr", "end_pos": 61, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr61", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538455", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538455", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32KV8", "url": "https://www.uniprot.org/uniprotkb/Q32KV8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KV8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 391, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KV8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KV8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 61, 251 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KX0-1", "uniprot_ac": "Q32KX0", "uniprot_id": "ISOC2_BOVIN", "mass": { "chemical_mass": 22420.0, "monoisotopic_mass": 22420.0 }, "refseq": { "ac": "NP_001033212", "name": "isochorismatase domain-containing protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033212" }, "gene_names": [ { "name": "ISOC2", "type": "recommended", "evidence": [ { "id": "Q32KX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KX0" } ] }, { "name": "ISOC2", "type": "synonym", "evidence": [ { "id": "NP_001033212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033212" } ] } ], "protein_names": [ { "name": "Isochorismatase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q32KX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KX0/entry#names_and_taxonomy" } ] }, { "name": "isochorismatase domain-containing protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033212" } ] }, { "name": "isochorismatase domain-containing protein 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033212" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KX0", "url": "https://www.uniprot.org/uniprotkb/Q32KX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISOC2", "url": "https://www.uniprot.org/uniprotkb/Q32KX0", "locus": { "chromosome": "18", "start_pos": 62060605, "end_pos": 62053844, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015950", "url": "https://www.ensembl.org/id/ENSBTAG00000015950" } ] } } ], "crossref": [ { "id": "Q32KX0", "url": "https://alphafold.ebi.ac.uk/entry/Q32KX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516212", "url": "https://www.ncbi.nlm.nih.gov/gene/516212", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516212", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516212", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KX0", "url": "https://www.orthodb.org/?gene=Q32KX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033212", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KX0", "url": "https://www.uniprot.org/uniprotkb/Q32KX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KX0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KX0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAARPALGRVLPGSSMLFLCDMQEKFRHVVYFRQIVSMAARMLKVARLLSVPTVLTEQYPQGLGPTVPELGAQGLQPYSKTCFSMVPAVQQELDARPQLRSVLLCGVETQACILQTALDLLDRGLQVHVVVDACTSRSQVDRLVALSRLRQSGAFLSTSEGLIFQLVGDATHPQFKEIQKLVKEPSPDSGLLGLFQDQNPLFR", "length": 204, "header": "sp|Q32KX0-1|ISOC2_BOVIN Isoform 1 of Isochorismatase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ISOC2 PE=2 SV=1 CANONICAL=Q32KX0-1" }, "isoforms": [ { "isoform_ac": "Q32KX0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KX0/entry#Q32KX0-1", "sequence": { "sequence": "MAAARPALGRVLPGSSMLFLCDMQEKFRHVVYFRQIVSMAARMLKVARLLSVPTVLTEQYPQGLGPTVPELGAQGLQPYSKTCFSMVPAVQQELDARPQLRSVLLCGVETQACILQTALDLLDRGLQVHVVVDACTSRSQVDRLVALSRLRQSGAFLSTSEGLIFQLVGDATHPQFKEIQKLVKEPSPDSGLLGLFQDQNPLFR", "length": 204, "header": "sp|Q32KX0-1|ISOC2_BOVIN Isoform 1 of Isochorismatase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ISOC2 PE=2 SV=1 CANONICAL=Q32KX0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516212", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516212", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KX0", "url": "https://www.uniprot.org/uniprotkb/Q32KX0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KX0", "url": "https://www.uniprot.org/uniprotkb/Q32KX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KX0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KX0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KX0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 67 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KX1-1", "uniprot_ac": "Q32KX1", "uniprot_id": "ARRD5_BOVIN", "mass": { "chemical_mass": 37043.0, "monoisotopic_mass": 37043.0 }, "refseq": { "ac": "NP_001121980", "name": "arrestin domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121980" }, "gene_names": [ { "name": "ARRDC5", "type": "recommended", "evidence": [ { "id": "Q32KX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ] }, { "name": "ARRDC5", "type": "synonym", "evidence": [ { "id": "NP_001121980", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121980" } ] } ], "protein_names": [ { "name": "Arrestin domain-containing protein 5", "type": "recommended", "evidence": [ { "id": "Q32KX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KX1/entry#names_and_taxonomy" } ] }, { "name": "arrestin domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001121980", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121980" } ] } ], "function": [ { "annotation": "Plays an essential role in spermatogenesis. May be involved in the anchoring of the sperm head to the tail during spermatogenesis by affecting SEC22A-mediated SUN5 and NDC1 transport and localization.", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1#function" }, { "database": "UniProtKB", "id": "Q497K5", "url": "https://www.uniprot.org/uniprotkb/Q497K5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARRDC5", "url": "https://www.uniprot.org/uniprotkb/Q32KX1", "locus": { "chromosome": "7", "start_pos": 19274362, "end_pos": 19254599, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031673", "url": "https://www.ensembl.org/id/ENSBTAG00000031673" } ] } } ], "crossref": [ { "id": "Q32KX1", "url": "https://alphafold.ebi.ac.uk/entry/Q32KX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "617727", "url": "https://www.ncbi.nlm.nih.gov/gene/617727", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617727", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617727", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KX1", "url": "https://www.orthodb.org/?gene=Q32KX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11188:SF172", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11188:SF172", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001121980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121980", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KX1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVVKSIELVLPKDAVYLAGCIIEGQVVLTLNSTLVDPIVKVELVGRGYVEWNEETGASRDYSREVICNNKADYVHKTKTFPVEDNWLSAGSHTFDFHFNLPPRLPSTFTSKIGNIFYFVQASCMGREHILAKKKIYLMVQGTSSIFHSEKSLQNPLFVEAEKKVSYNCCSQGTICLQIQMEKNTFTPGERDIFTTEINNQTSKCIKTVIFALYAHVHYEGFTPNAERRSRVDSSELLRQEANTHITAFNTTKIVSTFHLPPVLSVSGSGSQDSEIMNTQYELVSTVHLPWTLTSVKAKVPIIITSNPVDSNQTAAGCRTRAPLPVSPDQQN", "length": 332, "header": "sp|Q32KX1-1|ARRD5_BOVIN Isoform 1 of Arrestin domain-containing protein 5 OS=Bos taurus OX=9913 GN=ARRDC5 PE=2 SV=2 CANONICAL=Q32KX1-1" }, "isoforms": [ { "isoform_ac": "Q32KX1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1/entry#Q32KX1-1", "sequence": { "sequence": "MSVVKSIELVLPKDAVYLAGCIIEGQVVLTLNSTLVDPIVKVELVGRGYVEWNEETGASRDYSREVICNNKADYVHKTKTFPVEDNWLSAGSHTFDFHFNLPPRLPSTFTSKIGNIFYFVQASCMGREHILAKKKIYLMVQGTSSIFHSEKSLQNPLFVEAEKKVSYNCCSQGTICLQIQMEKNTFTPGERDIFTTEINNQTSKCIKTVIFALYAHVHYEGFTPNAERRSRVDSSELLRQEANTHITAFNTTKIVSTFHLPPVLSVSGSGSQDSEIMNTQYELVSTVHLPWTLTSVKAKVPIIITSNPVDSNQTAAGCRTRAPLPVSPDQQN", "length": 332, "header": "sp|Q32KX1-1|ARRD5_BOVIN Isoform 1 of Arrestin domain-containing protein 5 OS=Bos taurus OX=9913 GN=ARRDC5 PE=2 SV=2 CANONICAL=Q32KX1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617727", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617727", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32KX1", "url": "https://www.uniprot.org/uniprotkb/Q32KX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 332, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KY8-1", "uniprot_ac": "Q32KY8", "uniprot_id": "ASB17_BOVIN", "mass": { "chemical_mass": 34253.0, "monoisotopic_mass": 34253.0 }, "refseq": { "ac": "NP_001069898", "name": "ankyrin repeat and SOCS box protein 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069898" }, "gene_names": [ { "name": "ASB17", "type": "recommended", "evidence": [ { "id": "Q32KY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY8" } ] }, { "name": "ASB17", "type": "synonym", "evidence": [ { "id": "NP_001069898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069898" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 17", "type": "recommended", "evidence": [ { "id": "Q32KY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY8/entry#names_and_taxonomy" } ] }, { "name": "ASB-17", "type": "synonym", "evidence": [ { "id": "NP_001069898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069898" }, { "id": "Q32KY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY8/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 17", "type": "synonym", "evidence": [ { "id": "NP_001069898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069898" } ] } ], "function": [ { "annotation": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q32KY8", "url": "https://www.uniprot.org/uniprotkb/Q32KY8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KY8", "url": "https://www.uniprot.org/uniprotkb/Q32KY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB17", "url": "https://www.uniprot.org/uniprotkb/Q32KY8", "locus": { "chromosome": "3", "start_pos": 68954422, "end_pos": 68936675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005864", "url": "https://www.ensembl.org/id/ENSBTAG00000005864" } ] } } ], "crossref": [ { "id": "Q32KY8", "url": "https://alphafold.ebi.ac.uk/entry/Q32KY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005864", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005864", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616654", "url": "https://www.ncbi.nlm.nih.gov/gene/616654", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616654", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616654", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KLCHKTS", "url": "https://omabrowser.org/oma/group/KLCHKTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KY8", "url": "https://www.orthodb.org/?gene=Q32KY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20966:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20966:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069898", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KY8", "url": "https://www.uniprot.org/uniprotkb/Q32KY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KY8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKSSKLCCKTSCPRSNIFCSLVDKVFKRPSLQSLHQWGYHCYEPRVYRTLAKILRYVDLEGFDILLSDYIAFVEKSGCHLEVNFNLEFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSFNLALIWRTFTPVYCPSPLSGITPLLYVAQTRQSNILKILLQYGILERENNPINIVLTILLYPSRVRIMVDHELVDIEEDAKTCLVLCSRVLSTISIREIEMQLSLGRRPIISNWLDYIPSTRYKDPCELLHLCRITIRAQLLTNNMLPNGIFSLLIPVCLQNYLNLES", "length": 295, "header": "sp|Q32KY8-1|ASB17_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 17 OS=Bos taurus OX=9913 GN=ASB17 PE=2 SV=1 CANONICAL=Q32KY8-1" }, "isoforms": [ { "isoform_ac": "Q32KY8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KY8/entry#Q32KY8-1", "sequence": { "sequence": "MSKSSKLCCKTSCPRSNIFCSLVDKVFKRPSLQSLHQWGYHCYEPRVYRTLAKILRYVDLEGFDILLSDYIAFVEKSGCHLEVNFNLEFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSFNLALIWRTFTPVYCPSPLSGITPLLYVAQTRQSNILKILLQYGILERENNPINIVLTILLYPSRVRIMVDHELVDIEEDAKTCLVLCSRVLSTISIREIEMQLSLGRRPIISNWLDYIPSTRYKDPCELLHLCRITIRAQLLTNNMLPNGIFSLLIPVCLQNYLNLES", "length": 295, "header": "sp|Q32KY8-1|ASB17_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 17 OS=Bos taurus OX=9913 GN=ASB17 PE=2 SV=1 CANONICAL=Q32KY8-1" }, "locus": { "chromosome": "3", "start_pos": 68954345, "end_pos": 68936796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007708.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007708.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007708.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007708.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616654", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616654", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IKE2-1", "protein_name": "Ankyrin repeat and SOCS box protein 17", "gene_name": "Asb17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNNSFKLCRKTSFPRGNIFCNLIDKIVKRPSLQFLGQWGYHCYEPRIYRTLAKILRYVDLDGFDILLTDYIAFVEKSGHRFELNFNLEFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCNLALIWRTFTPVYCPSPLSGITPLLYVAQTRQSNILKILLQYGILEREKNPINIVLTILLYPSRVRIMVDHELIDIQEDAKTCLTLCSRVLSAISVREIETQLSLGRRPIIQNWLDYIPPTRYKDPCELVHLCRITIRTQLLANNMLPNGIFSLLIPARLQNFLNLES", "length": 295 }, "evidence": [ { "id": "Q32KY8", "url": "https://omabrowser.org/oma/group/Q32KY8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8CHM6-1", "protein_name": "Ankyrin repeat and SOCS box protein 17", "gene_name": "Asb17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNSSKLCRKTSFPRGNIFCNLIDKIVKRPSLQFLGQWGYHCYEPRIYRTLAKILRYVDLDGFDILLTDYIAFVEKSGHRFELNFNLEFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCSLALIWRTFTPVYCPSPLSGITPLLYVAQTRQSNILKILLQYGILEREKNPINIVLTILLYPSRVRIMVDHELIDIQEDAKTCLTLCSRVLSVISVREIETQLNLGRRPIIQNWLDYIPPTRYKDPCELVHLCRITIRTQLLANNMLPNGIFSLLIPTRLQNFLNLES", "length": 295 }, "evidence": [ { "id": "Q32KY8", "url": "https://omabrowser.org/oma/group/Q32KY8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHP9-1", "protein_name": "Ankyrin repeat and SOCS box protein 17", "gene_name": "Asb17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNNSSKLCRKTSFPRSNIFCNLVDKIVKRPSLQFLGQWGYHCYEPRIYRTLAKILRYVDLDGFDILLTDYIAFVEKSGHRFELNFNLEFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCSLALIWRTFTPVYCPSPLSGITPLLYVAQTRQSNILKILLQYGILEREKNPINIVLTILLYPSRVRIMVDHELIDIQEDAKTCLMLCSRVLSTISVREIETQLSLGRRPIIQNWLDYIPPTRYKDPCELVHLCRITIRTQLLANNMLPNGIFSLLIPTRLQNFLNLES", "length": 295 }, "evidence": [ { "id": "Q32KY8", "url": "https://omabrowser.org/oma/group/Q32KY8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXJ9-1", "protein_name": "Ankyrin repeat and SOCS box protein 17", "gene_name": "ASB17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKSTKLCGKTSCPRSNIFCNLLDKIVKRPSLQFLGQWGYHCYEPRIYRSLAKILRYVDLDGFDALLTDYIAFVEKSGYRFEVSFNLDFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCNLALIWRTFTPVYCPSPLSGITPLFYVAQTRQSNIFKILLQYGILEREKNPINIVLTIVLYPSRVRVMVDRELADIHEDAKTCLVLCSRVLSVISVKEIKTQLSLGRHPIISNWFDYIPSTRYKDPCELLHLCRLTIRNQLLTNNMLPDGIFSLLIPARLQNYLNLEI", "length": 295 }, "evidence": [ { "id": "Q32KY8", "url": "https://omabrowser.org/oma/group/Q32KY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q32KY8", "url": "https://www.uniprot.org/uniprotkb/Q32KY8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "apical ectoplasmic specialization", "id": "GO:0061831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061831", "evidence": [ { "database": "UniProtKB", "id": "Q32KY8", "url": "https://www.uniprot.org/uniprotkb/Q32KY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KY8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY8" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 232, "end_pos": 295, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L03-1", "uniprot_ac": "Q32L03", "uniprot_id": "MED11_BOVIN", "mass": { "chemical_mass": 13157.0, "monoisotopic_mass": 13157.0 }, "refseq": { "ac": "NP_001033173", "name": "mediator of RNA polymerase II transcription subunit 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033173" }, "gene_names": [ { "name": "MED11", "type": "recommended", "evidence": [ { "id": "Q32L03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ] }, { "name": "MED11", "type": "synonym", "evidence": [ { "id": "NP_001033173", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033173" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 11", "type": "recommended", "evidence": [ { "id": "Q32L03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L03/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 11", "type": "synonym", "evidence": [ { "id": "Q32L03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L03/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 11", "type": "synonym", "evidence": [ { "id": "NP_001033173", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033173" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03#function" }, { "database": "UniProtKB", "id": "Q9P086", "url": "https://www.uniprot.org/uniprotkb/Q9P086#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED11", "url": "https://www.uniprot.org/uniprotkb/Q32L03", "locus": { "chromosome": "19", "start_pos": 26619637, "end_pos": 26621596, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018314", "url": "https://www.ensembl.org/id/ENSBTAG00000018314" } ] } } ], "crossref": [ { "id": "Q32L03", "url": "https://alphafold.ebi.ac.uk/entry/Q32L03", "database": "AlphaFoldDB", "categories": [] }, { "id": "511672", "url": "https://www.ncbi.nlm.nih.gov/gene/511672", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511672", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511672", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L03", "url": "https://www.orthodb.org/?gene=Q32L03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033173", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L03-1", "url": "https://www.uniprot.org/uniprotkb/Q32L03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRLDYARLKLSEVARTCEQMLEN", "length": 117, "header": "sp|Q32L03-1|MED11_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 11 OS=Bos taurus OX=9913 GN=MED11 PE=3 SV=1 CANONICAL=Q32L03-1" }, "isoforms": [ { "isoform_ac": "Q32L03-1", "url": "https://www.uniprot.org/uniprotkb/Q32L03/entry#Q32L03-1", "sequence": { "sequence": "MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRLDYARLKLSEVARTCEQMLEN", "length": 117, "header": "sp|Q32L03-1|MED11_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 11 OS=Bos taurus OX=9913 GN=MED11 PE=3 SV=1 CANONICAL=Q32L03-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511672", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511672", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q32L03", "url": "https://www.uniprot.org/uniprotkb/Q32L03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L03-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 117, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L03-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L03" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L15-1", "uniprot_ac": "Q32L15", "uniprot_id": "RN141_BOVIN", "mass": { "chemical_mass": 25509.0, "monoisotopic_mass": 25509.0 }, "refseq": { "ac": "NP_001035656", "name": "RING finger protein 141", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035656" }, "gene_names": [ { "name": "RNF141", "type": "recommended", "evidence": [ { "id": "Q32L15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ] }, { "name": "RNF141", "type": "synonym", "evidence": [ { "id": "NP_001035656", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035656" } ] } ], "protein_names": [ { "name": "RING finger protein 141", "type": "recommended", "evidence": [ { "id": "Q32L15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L15/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 141", "type": "synonym", "evidence": [ { "id": "NP_001035656", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035656" } ] } ], "function": [ { "annotation": "May be involved in spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF141", "url": "https://www.uniprot.org/uniprotkb/Q32L15", "locus": { "chromosome": "15", "start_pos": 42177567, "end_pos": 42143426, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015824", "url": "https://www.ensembl.org/id/ENSBTAG00000015824" } ] } } ], "crossref": [ { "id": "Q32L15", "url": "https://alphafold.ebi.ac.uk/entry/Q32L15", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015824", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015824", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16545", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16545", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539455", "url": "https://www.ncbi.nlm.nih.gov/gene/539455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539455", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539455", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RHRNCPV", "url": "https://omabrowser.org/oma/group/RHRNCPV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L15", "url": "https://www.orthodb.org/?gene=Q32L15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12109", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12109", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12109:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12109:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035656", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L15-1", "url": "https://www.uniprot.org/uniprotkb/Q32L15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQQISDQTQLVLNKLPEKVAKHVMLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEDADENSASVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 230, "header": "sp|Q32L15-1|RN141_BOVIN Isoform 1 of RING finger protein 141 OS=Bos taurus OX=9913 GN=RNF141 PE=2 SV=1 CANONICAL=Q32L15-1" }, "isoforms": [ { "isoform_ac": "Q32L15-1", "url": "https://www.uniprot.org/uniprotkb/Q32L15/entry#Q32L15-1", "sequence": { "sequence": "MGQQISDQTQLVLNKLPEKVAKHVMLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEDADENSASVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 230, "header": "sp|Q32L15-1|RN141_BOVIN Isoform 1 of RING finger protein 141 OS=Bos taurus OX=9913 GN=RNF141 PE=2 SV=1 CANONICAL=Q32L15-1" }, "locus": { "chromosome": "15", "start_pos": 42177366, "end_pos": 42153022, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021020.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021020.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021020.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021020.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539455", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539455", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJU8-1", "protein_name": "RING finger protein 141", "gene_name": "RNF141", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQQISDQTQLVLNKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTTSEDPDENSSSLTSCQASFWMGRVKQLTDEEECCICMDGRADLILPCTHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 231 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HYL6-1", "protein_name": "RING finger protein 141", "gene_name": "Rnf141", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDVTAKVAAGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQNSTSEEPDGNPSSITSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 230 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ZM74-1", "protein_name": "RING finger protein 141", "gene_name": "RNF141", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGQQISSQTQTVMNKLPEKVAKHASLVQESGFLTYEEFLGRVAELNDVTAKLASGQEKHLLFEVQPGSDSSAFWKVVVRIICTKINKTSGIVEASRILNLYQFVQLYKDITSQAAGVLAQSETSEEAAESLTSVSSSQASLWMGRLKQPTDEDECCICMDGRVDLILPCAHSFCQKCIDKWSDRHRSCPVCRRQVTGAGDSWVVSDAPTEDDIATYILNMVDEVGQPLRP", "length": 230 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6IV56-1", "protein_name": "RING finger protein 141", "gene_name": "rnf141", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGQQLSGQAVTRLPEKLIKHVGLVRDSGYLTYDEFLGRVAELNDVTAKLASGQKKHLLFEVQPGSDSSALWKVAVRIVCTKINKEDGMVEASRIMNLYQFIQLYKDITSQAAEVFSSNVAAEGSSEDTCQASMWMGRVKQLTDEEECCICMDGKADLILPCAHSFCQKCIDKWSGQSRNCPVCRIQVTAANESWVMSDAPTGEDVAGYILNLADEAGHPHRP", "length": 222 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8WVD5-1", "protein_name": "RING finger protein 141", "gene_name": "RNF141", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEEPDENSSSVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 230 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99MB7-1", "protein_name": "RING finger protein 141", "gene_name": "Rnf141", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDVTAKVAAGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEEPDENPSSVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP", "length": 230 }, "evidence": [ { "id": "Q32L15", "url": "https://omabrowser.org/oma/group/Q32L15/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "Q32L15", "url": "https://www.uniprot.org/uniprotkb/Q32L15" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L15-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L15-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L15" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L19-1", "uniprot_ac": "Q32L19", "uniprot_id": "MND1_BOVIN", "mass": { "chemical_mass": 23984.0, "monoisotopic_mass": 23984.0 }, "refseq": { "ac": "NP_001033312", "name": "meiotic nuclear division protein 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033312" }, "gene_names": [ { "name": "MND1", "type": "recommended", "evidence": [ { "id": "Q32L19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L19" } ] }, { "name": "MND1", "type": "synonym", "evidence": [ { "id": "NP_001033312", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033312" } ] } ], "protein_names": [ { "name": "Meiotic nuclear division protein 1 homolog", "type": "recommended", "evidence": [ { "id": "Q32L19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L19/entry#names_and_taxonomy" } ] }, { "name": "meiotic nuclear division protein 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033312", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033312" } ] }, { "name": "meiotic nuclear divisions 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033312", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033312" } ] } ], "function": [ { "annotation": "Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19#function" }, { "database": "UniProtKB", "id": "Q8K396", "url": "https://www.uniprot.org/uniprotkb/Q8K396#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MND1", "url": "https://www.uniprot.org/uniprotkb/Q32L19", "locus": { "chromosome": "17", "start_pos": 4187768, "end_pos": 4298314, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000281", "url": "https://www.ensembl.org/id/ENSBTAG00000000281" } ] } } ], "crossref": [ { "id": "Q32L19", "url": "https://alphafold.ebi.ac.uk/entry/Q32L19", "database": "AlphaFoldDB", "categories": [] }, { "id": "618239", "url": "https://www.ncbi.nlm.nih.gov/gene/618239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618239", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618239", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L19", "url": "https://www.orthodb.org/?gene=Q32L19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31398:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31398:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033312", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L19-1", "url": "https://www.uniprot.org/uniprotkb/Q32L19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITTMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 205, "header": "sp|Q32L19-1|MND1_BOVIN Isoform 1 of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=2 SV=1 CANONICAL=Q32L19-1" }, "isoforms": [ { "isoform_ac": "Q32L19-1", "url": "https://www.uniprot.org/uniprotkb/Q32L19/entry#Q32L19-1", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITTMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 205, "header": "sp|Q32L19-1|MND1_BOVIN Isoform 1 of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=2 SV=1 CANONICAL=Q32L19-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618239", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618239", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "Q32L19", "url": "https://www.uniprot.org/uniprotkb/Q32L19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L19" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L34-1", "uniprot_ac": "Q32L34", "uniprot_id": "HMGB4_BOVIN", "mass": { "chemical_mass": 23021.0, "monoisotopic_mass": 23021.0 }, "refseq": { "ac": "NP_001035652", "name": "high mobility group protein B4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035652" }, "gene_names": [ { "name": "HMGB4", "type": "recommended", "evidence": [ { "id": "Q32L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ] }, { "name": "HMGB4", "type": "synonym", "evidence": [ { "id": "NP_001035652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035652" } ] } ], "protein_names": [ { "name": "High mobility group protein B4", "type": "recommended", "evidence": [ { "id": "Q32L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L34/entry#names_and_taxonomy" } ] }, { "name": "high mobility group protein B4", "type": "synonym", "evidence": [ { "id": "NP_001035652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035652" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HMGB4", "url": "https://www.uniprot.org/uniprotkb/Q32L34", "locus": { "chromosome": "3", "start_pos": 111927003, "end_pos": 111927727, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000335", "url": "https://www.ensembl.org/id/ENSBTAG00000000335" } ] } } ], "crossref": [ { "id": "Q32L34", "url": "https://alphafold.ebi.ac.uk/entry/Q32L34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000335", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000335", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21978", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21978", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21979", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21979", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539195", "url": "https://www.ncbi.nlm.nih.gov/gene/539195", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539195", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539195", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MWSAKTD", "url": "https://omabrowser.org/oma/group/MWSAKTD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L34", "url": "https://www.orthodb.org/?gene=Q32L34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035652", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L34-1", "url": "https://www.uniprot.org/uniprotkb/Q32L34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRDQLKPKANVSSYIHFLLNYRNKFKEQQPNTYLGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQEEMMNYFGRRKKRRKRDPHAPRRPPSSFLLFCQDHYAQLKSENPSWSVVQVAKASGKMWSAKTDVDKQPYEQRAALLRAKYREELSVYRNQFNARKTCLQESATNQCREFEQAESDTTDGSN", "length": 194, "header": "sp|Q32L34-1|HMGB4_BOVIN Isoform 1 of High mobility group protein B4 OS=Bos taurus OX=9913 GN=HMGB4 PE=2 SV=1 CANONICAL=Q32L34-1" }, "isoforms": [ { "isoform_ac": "Q32L34-1", "url": "https://www.uniprot.org/uniprotkb/Q32L34/entry#Q32L34-1", "sequence": { "sequence": "MGKRDQLKPKANVSSYIHFLLNYRNKFKEQQPNTYLGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQEEMMNYFGRRKKRRKRDPHAPRRPPSSFLLFCQDHYAQLKSENPSWSVVQVAKASGKMWSAKTDVDKQPYEQRAALLRAKYREELSVYRNQFNARKTCLQESATNQCREFEQAESDTTDGSN", "length": 194, "header": "sp|Q32L34-1|HMGB4_BOVIN Isoform 1 of High mobility group protein B4 OS=Bos taurus OX=9913 GN=HMGB4 PE=2 SV=1 CANONICAL=Q32L34-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539195", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539195", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LE77-1", "protein_name": "High mobility group protein B4", "gene_name": "HMGB4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKEIQLKPKANVSSYIHFLLNYRNKFKEQQPNTYLGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQEEMRNYVGGKRKRRKRDPQAPRRPPSSFLLFCQDNYAQLKRENPNWSVAQVAKASARMWSTTTDVDKQPYEQRAALLRAKYHEELSVYQKQFNGSKKSPQGVAPIQGKGLGQTESDIADGSNQK", "length": 196 }, "evidence": [ { "id": "Q32L34", "url": "https://omabrowser.org/oma/group/Q32L34/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6P8W9-1", "protein_name": "High mobility group protein B4", "gene_name": "Hmgb4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEKDQLRPKVNVSSYIHFMLNFRNKFKEQQPNTYLGFKEFSRKCSEKWRSISKHEKAKYEALAELDKARYQQEMMNYIGKRRKRRKRDPKAPRKPPSSFLLFSRDHYAMLKQENPDWTVVQVAKAAGKMWSTTDEAEKKPYEQKAALMRAKYFEEQEAYRNQCQGRKGNFLESAKTSLKQ", "length": 181 }, "evidence": [ { "id": "Q32L34", "url": "https://omabrowser.org/oma/group/Q32L34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WW32-1", "protein_name": "High mobility group protein B4", "gene_name": "HMGB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKEIQLKPKANVSSYVHFLLNYRNKFKEQQPNTYVGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQEEMMNYVGKRKKRRKRDPQEPRRPPSSFLLFCQDHYAQLKRENPNWSVVQVAKATGKMWSTATDLEKHPYEQRVALLRAKYFEELELYRKQCNARKKYRMSARNRCRGKRVRQS", "length": 186 }, "evidence": [ { "id": "Q32L34", "url": "https://omabrowser.org/oma/group/Q32L34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "Q32L34", "url": "https://www.uniprot.org/uniprotkb/Q32L34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L34" }, { "id": "PRU00267", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00267" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "HMG box 1", "eco_id": "ECO_0000255", "start_pos": 9, "end_pos": 79, "start_aa": "Pro", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L34" }, { "id": "PRU00267", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00267" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "HMG box 2", "eco_id": "ECO_0000255", "start_pos": 93, "end_pos": 161, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L41-1", "uniprot_ac": "Q32L41", "uniprot_id": "GFRP_BOVIN", "mass": { "chemical_mass": 9557.0, "monoisotopic_mass": 9557.0 }, "refseq": { "ac": "NP_001107998", "name": "GTP cyclohydrolase 1 feedback regulatory protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998" }, "gene_names": [ { "name": "GCHFR", "type": "recommended", "evidence": [ { "id": "Q32L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ] }, { "name": "GCHFR", "type": "synonym", "evidence": [ { "id": "NP_001107998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998" } ] } ], "protein_names": [ { "name": "GTP cyclohydrolase 1 feedback regulatory protein", "type": "recommended", "evidence": [ { "id": "Q32L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L41/entry#names_and_taxonomy" } ] }, { "name": "GFRP", "type": "synonym", "evidence": [ { "id": "NP_001107998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998" }, { "id": "Q32L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L41/entry#names_and_taxonomy" } ] }, { "name": "GTP cyclohydrolase 1 feedback regulatory protein", "type": "synonym", "evidence": [ { "id": "NP_001107998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998" } ] }, { "name": "GTP cyclohydrolase I feedback regulatory protein", "type": "synonym", "evidence": [ { "id": "NP_001107998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998" }, { "id": "Q32L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L41/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCHFR", "url": "https://www.uniprot.org/uniprotkb/Q32L41", "locus": {} } ], "crossref": [ { "id": "Q32L41", "url": "https://alphafold.ebi.ac.uk/entry/Q32L41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013477", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013477", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617650", "url": "https://www.ncbi.nlm.nih.gov/gene/617650", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617650", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617650", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PNLMHYL", "url": "https://omabrowser.org/oma/group/PNLMHYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L41", "url": "https://www.orthodb.org/?gene=Q32L41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16852", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16852", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16852:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16852:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1474151", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474151", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001107998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L41-1", "url": "https://www.uniprot.org/uniprotkb/Q32L41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPYLLISTQIRMEVGPTVVGDEHSDPELMQHLGASKRSVLGNNFSEYYVNDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE", "length": 84, "header": "sp|Q32L41-1|GFRP_BOVIN Isoform 1 of GTP cyclohydrolase 1 feedback regulatory protein OS=Bos taurus OX=9913 GN=GCHFR PE=3 SV=1 CANONICAL=Q32L41-1" }, "isoforms": [ { "isoform_ac": "Q32L41-1", "url": "https://www.uniprot.org/uniprotkb/Q32L41/entry#Q32L41-1", "sequence": { "sequence": "MPYLLISTQIRMEVGPTVVGDEHSDPELMQHLGASKRSVLGNNFSEYYVNDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE", "length": 84, "header": "sp|Q32L41-1|GFRP_BOVIN Isoform 1 of GTP cyclohydrolase 1 feedback regulatory protein OS=Bos taurus OX=9913 GN=GCHFR PE=3 SV=1 CANONICAL=Q32L41-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 17, "start_aa": "Thr", "end_pos": 17, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617650", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617650", "resource": "KEGG Pathway" }, { "id": "R-BTA-1474151", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474151", "resource": "Reactome", "description": "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZT4-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPYLLISTQIRMEVGPTMVGDEHSDPNLMQFLGATKRNMLGNHFWEYYVNDAPRIVLNKLESCGYRVVSMTGVGQTLVWCLHKE", "length": 84 }, "evidence": [ { "id": "Q32L41", "url": "https://omabrowser.org/oma/group/Q32L41/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P30047-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE", "length": 84 }, "evidence": [ { "id": "Q32L41", "url": "https://omabrowser.org/oma/group/Q32L41/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P99025-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "Gchfr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPYLLISTQIRMEVGPTMVGDEHSDPELMQHLGASKRSVLGNNFYEYYVNDPPRIVLDKLECKGFRVLSMTGVGQTLVWCLHKE", "length": 84 }, "evidence": [ { "id": "Q32L41", "url": "https://omabrowser.org/oma/group/Q32L41/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PBT6-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "gchfr", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPYILISTQIRLETGPTMVGDEYSDPSIMNYLGARKITVLGNNFSEYHVDEPPRLVLDKLDKIGYRVVSMTGVGQTLVWCLHKESSNTL", "length": 89 }, "evidence": [ { "id": "Q32L41", "url": "https://omabrowser.org/oma/group/Q32L41/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of biosynthetic process", "id": "GO:0009890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009890", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP cyclohydrolase binding", "id": "GO:0044549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044549", "evidence": [ { "database": "UniProtKB", "id": "Q32L41", "url": "https://www.uniprot.org/uniprotkb/Q32L41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L41-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 84, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L41-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L41" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 17 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L49-1", "uniprot_ac": "Q32L49", "uniprot_id": "GAR5A_BOVIN", "mass": { "chemical_mass": 24228.0, "monoisotopic_mass": 24228.0 }, "refseq": { "ac": "NP_001192304", "name": "Golgi-associated RAB2 interactor protein 5A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" }, "gene_names": [ { "name": "GARIN5A", "type": "recommended", "evidence": [ { "id": "Q32L49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ] }, { "name": "FAM71E1", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" }, { "id": "Q32L49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ] }, { "name": "GARIN5A", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" } ] } ], "protein_names": [ { "name": "Golgi-associated RAB2 interactor protein 5A", "type": "recommended", "evidence": [ { "id": "Q32L49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L49/entry#names_and_taxonomy" } ] }, { "name": "Golgi associated RAB2 interactor protein 5A", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" } ] }, { "name": "Golgi-associated RAB2 interactor protein 5A", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" } ] }, { "name": "family with sequence similarity 71 member E1", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" } ] }, { "name": "protein FAM71E1", "type": "synonym", "evidence": [ { "id": "NP_001192304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304" } ] } ], "function": [ { "annotation": "RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.", "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49#function" }, { "database": "UniProtKB", "id": "A1L3C1", "url": "https://www.uniprot.org/uniprotkb/A1L3C1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GARIN5A", "url": "https://www.uniprot.org/uniprotkb/Q32L49", "locus": { "chromosome": "18", "start_pos": 56607998, "end_pos": 56613659, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020082", "url": "https://www.ensembl.org/id/ENSBTAG00000020082" } ] } } ], "crossref": [ { "id": "Q32L49", "url": "https://alphafold.ebi.ac.uk/entry/Q32L49", "database": "AlphaFoldDB", "categories": [] }, { "id": "617892", "url": "https://www.ncbi.nlm.nih.gov/gene/617892", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617892", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617892", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L49", "url": "https://www.orthodb.org/?gene=Q32L49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192304", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L49-1", "url": "https://www.uniprot.org/uniprotkb/Q32L49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRGHEPKPAFGGAGEAGPGVMAERPLVPACPTGRPGRLQRHLLSGEFDQLRDFRIFESNFVQVTRLGEVANKVTMGVAASSPALELPDLLLLAGPAKENGHLQLFGLFPLQFVQLFVHDESRWQLKVKFRTGRAFYLQLRAPPESRDREFGQWVRLLYRLRFHSAQGAVPFTQDYSALEDDEDDDEDEDRDLPAGELQAMEARLDPQMSELWGL", "length": 215, "header": "sp|Q32L49-1|GAR5A_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 5A OS=Bos taurus OX=9913 GN=GARIN5A PE=2 SV=2 CANONICAL=Q32L49-1" }, "isoforms": [ { "isoform_ac": "Q32L49-1", "url": "https://www.uniprot.org/uniprotkb/Q32L49/entry#Q32L49-1", "sequence": { "sequence": "MKRGHEPKPAFGGAGEAGPGVMAERPLVPACPTGRPGRLQRHLLSGEFDQLRDFRIFESNFVQVTRLGEVANKVTMGVAASSPALELPDLLLLAGPAKENGHLQLFGLFPLQFVQLFVHDESRWQLKVKFRTGRAFYLQLRAPPESRDREFGQWVRLLYRLRFHSAQGAVPFTQDYSALEDDEDDDEDEDRDLPAGELQAMEARLDPQMSELWGL", "length": 215, "header": "sp|Q32L49-1|GAR5A_BOVIN Isoform 1 of Golgi-associated RAB2 interactor protein 5A OS=Bos taurus OX=9913 GN=GARIN5A PE=2 SV=2 CANONICAL=Q32L49-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617892", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617892", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "Q32L49", "url": "https://www.uniprot.org/uniprotkb/Q32L49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L50-1", "uniprot_ac": "Q32L50", "uniprot_id": "SBSPO_BOVIN", "mass": { "chemical_mass": 29310.0, "monoisotopic_mass": 29310.0 }, "refseq": { "ac": "NP_001069337", "name": "somatomedin-B and thrombospondin type-1 domain-containing protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" }, "gene_names": [ { "name": "SBSPON", "type": "recommended", "evidence": [ { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50" } ] }, { "name": "C14H8orf84", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" } ] }, { "name": "RPESP", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" }, { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50" } ] }, { "name": "SBSPON", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" } ] } ], "protein_names": [ { "name": "Somatomedin-B and thrombospondin type-1 domain-containing protein", "type": "recommended", "evidence": [ { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50/entry#names_and_taxonomy" } ] }, { "name": "RPE-spondin", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" }, { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50/entry#names_and_taxonomy" } ] }, { "name": "somatomedin-B and thrombospondin type-1 domain-containing protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" } ] }, { "name": "somatomedin-B and thrombospondin type-1 domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001069337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L50", "url": "https://www.uniprot.org/uniprotkb/Q32L50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SBSPON", "url": "https://www.uniprot.org/uniprotkb/Q32L50", "locus": { "chromosome": "14", "start_pos": 36436043, "end_pos": 36467496, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017249", "url": "https://www.ensembl.org/id/ENSBTAG00000017249" } ] } } ], "crossref": [ { "id": "Q32L50", "url": "https://alphafold.ebi.ac.uk/entry/Q32L50", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017249", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017249", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525332", "url": "https://www.ncbi.nlm.nih.gov/gene/525332", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525332", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525332", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAASPQW", "url": "https://omabrowser.org/oma/group/QAASPQW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L50", "url": "https://www.orthodb.org/?gene=Q32L50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20920:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20920:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069337", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L50", "url": "https://www.uniprot.org/uniprotkb/Q32L50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L50-1", "url": "https://www.uniprot.org/uniprotkb/Q32L50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLWMALCVLARLWPGALAGCADAGRCCPGRDPACFASGWRQDRVYGTCFCDQACRLTGDCCFDYARACPARPCIVGEWSPWSGCASQCRPTARVRRRAVQQEPQNGGEPCPALEERAGCLEYATPQGEDCGHAFVPAFITTSAFNKERTRQAASPHWTTSTEDAGYCMEFKTESLTHHCALENRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVEQCSCPAVHSFIFI", "length": 264, "header": "sp|Q32L50-1|SBSPO_BOVIN Isoform 1 of Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Bos taurus OX=9913 GN=SBSPON PE=2 SV=2 CANONICAL=Q32L50-1" }, "isoforms": [ { "isoform_ac": "Q32L50-1", "url": "https://www.uniprot.org/uniprotkb/Q32L50/entry#Q32L50-1", "sequence": { "sequence": "MRTLWMALCVLARLWPGALAGCADAGRCCPGRDPACFASGWRQDRVYGTCFCDQACRLTGDCCFDYARACPARPCIVGEWSPWSGCASQCRPTARVRRRAVQQEPQNGGEPCPALEERAGCLEYATPQGEDCGHAFVPAFITTSAFNKERTRQAASPHWTTSTEDAGYCMEFKTESLTHHCALENRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVEQCSCPAVHSFIFI", "length": 264, "header": "sp|Q32L50-1|SBSPO_BOVIN Isoform 1 of Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Bos taurus OX=9913 GN=SBSPON PE=2 SV=2 CANONICAL=Q32L50-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 227, "start_aa": "Asn", "end_pos": 227, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn227", "evidence": [ { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:525332", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525332", "resource": "KEGG Pathway" }, { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480WBM1-1", "protein_name": "Somatomedin B and thrombospondin type 1 domain containing", "gene_name": "SBSPON", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTLWMALCALARLWPGALGGCADAGRCCPGRDPACFASGWRLDRVYGTCFCDQACRLTGDCCFDYARACPARPCIVGEWSPWSGCADQCKPTARVRRRAVRQEPQNGGAPCPALEERAGCLEYATAQGQDCGHAFVPAFITTSAFNKERTRRAASPQWSADTEDAGYCMEFKTESLTHHCALENRPLTRWMQYLREGYTVCVGCQPPAMNAVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVEQCSCPAVHSFIFI", "length": 264 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M1QUS9-1", "protein_name": "Somatomedin-B and thrombospondin type-1 domain-containing protein", "gene_name": "sbspon", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGLLSVKQNALLLVATFFGMCHFSDGGCSGRCCQGSDFTCFTTDWRMDHVYGTCYCDEKCLKTKDCCFDYPAECPAQPCVVSEWSNWSGCAQPCQPSFRVRRRNVERLPQNNGEACLSLEEQAGCMEYQDHQGQFCSQTQGAAFITTMEYSKGRTHELYGAPVDAGFCMEFKMESLTAQCMGENRPYARWMQYLREGYTVCVACQPPANHSWGCQGDGNLAERNDLLHWQAVGNPPCRGTWRKVQRLQHCSCPQVHSFIFI", "length": 261 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0X7F1-1", "protein_name": "Somatomedin B and thrombospondin type 1 domain containing", "gene_name": "SBSPON", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTTTILCGVMAAEDISVLYISAKLNAALDPPATRTPVPHLPNPSALHGARGRRGREGRAGKGRAQPSRSPPPGPAARPPAQPAPRYRVSVTVVGDMGAVALSGALCLGLLWRLWAGAGGSCSERCCQGRDAACVSSGWREDGGYGTCYCDGGCRRTRDCCHDHGHACPAHPCIVGEWSHWSGCAEQCKPSLRIRRRYVQQEPTNAGEPCPALEEKAGCLEYLTYQGQDCGHEHVPAFITTSEYDKERKLRAASSPWPSDKETGYCVEFKTESLSHYCALENRPYARWMQYLREGHTVCVACQPPAMNTDTHRCSGDGHNADGGKILHWEAVGNSRCQGTWKKIRQLKQCSCPLVHSFIFT", "length": 360 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZS55-1", "protein_name": "Somatomedin B and thrombospondin, type 1 domain containing", "gene_name": "Sbspon", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRTLWMVLCALARLWPGALAGCAEAGRCCPGRDPACFARGWRLDRVYGTCFCDQACRLTGDCCFDYDRACPARPCFVGEWSPWSGCAGQCQPTMRVRRRSVHQEPLNGGAPCPPLEERAGCLEYSSSQGQDCGHSFVPAFITSSAFNKKRIVQAVSPQWPTHTEDAGYCMEFKTESLTAHCALDSRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLRWQAIGNPRCQGTWKKVRRAEQCSCPDVHRFIFI", "length": 264 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UPR9-1", "protein_name": "Somatomedin-B and thrombospondin type-1 domain-containing protein", "gene_name": "Sbspon", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLWMVLCALARLWPGALAGCAEAGRCCPGRDPACFARGWRLDRVYGTCFCDQACRLTGDCCFDYDRACPARPCFVGEWSPWSGCAGQCQPTTRVRRRSVRQEPLNGGAPCPPLEERAGCLEYSSSQSQDCGHSFVPAFITSSVFNKKRIIQAVSPQWSTHTKDAGYCMEFKTESLTPHCALVNSPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLRWQAIGNPRCQGTWKKVRRVEQCSCPDVHRFIFI", "length": 264 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVN8-1", "protein_name": "Somatomedin-B and thrombospondin type-1 domain-containing protein", "gene_name": "SBSPON", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTLWMALCALSRLWPGAQAGCAEAGRCCPGRDPACFARGWRLDRVYGTCFCDQACRFTGDCCFDYDRACPARPCFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGCLEYSTPQGQDCGHTYVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVDQCSCPAVHSFIFI", "length": 264 }, "evidence": [ { "id": "Q32L50", "url": "https://omabrowser.org/oma/group/Q32L50/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L50-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L50-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L50" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50" }, { "id": "PRU00350", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00350" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SMB", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 75, "start_aa": "Asp", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32L50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L50" }, { "id": "PRU00210", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00210" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TSP type-1", "eco_id": "ECO_0000255", "start_pos": 74, "end_pos": 127, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 227 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L59-1", "uniprot_ac": "Q32L59", "uniprot_id": "TMC5B_BOVIN", "mass": { "chemical_mass": 41358.0, "monoisotopic_mass": 41358.0 }, "refseq": { "ac": "NP_001069077", "name": "transmembrane and coiled-coil domain-containing protein 5B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069077" }, "gene_names": [ { "name": "TMCO5B", "type": "recommended", "evidence": [ { "id": "Q32L59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L59" } ] }, { "name": "TMCO5B", "type": "synonym", "evidence": [ { "id": "NP_001069077", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069077" } ] } ], "protein_names": [ { "name": "Transmembrane and coiled-coil domain-containing protein 5B", "type": "recommended", "evidence": [ { "id": "Q32L59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L59/entry#names_and_taxonomy" } ] }, { "name": "transmembrane and coiled-coil domain-containing protein 5B", "type": "synonym", "evidence": [ { "id": "NP_001069077", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069077" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L59", "url": "https://www.uniprot.org/uniprotkb/Q32L59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMCO5B", "url": "https://www.uniprot.org/uniprotkb/Q32L59", "locus": { "chromosome": "10", "start_pos": 29359775, "end_pos": 29343304, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021414", "url": "https://www.ensembl.org/id/ENSBTAG00000021414" } ] } } ], "crossref": [ { "id": "Q32L59", "url": "https://alphafold.ebi.ac.uk/entry/Q32L59", "database": "AlphaFoldDB", "categories": [] }, { "id": "513290", "url": "https://www.ncbi.nlm.nih.gov/gene/513290", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513290", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513290", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L59", "url": "https://www.orthodb.org/?gene=Q32L59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22422", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22422", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22422:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22422:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069077", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L59", "url": "https://www.uniprot.org/uniprotkb/Q32L59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L59-1", "url": "https://www.uniprot.org/uniprotkb/Q32L59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEAGQDPLDDVRDVMEIPKLEITKQNLDSLNSDLEKDLQRMDEANQVLLKKIQEKEETIQSLERDITLSVRQAREREELDHRTAEKEAALRDLELETAKLEKNKEILSRSVVEVQKEISRKFKNVSLDKEALKQMLAELKVKLQKSTESCASQEKELVKIESDYQSVYQLCEDQAHYIKKYQEILRQMEKEKEMLLLEKEVQRWRSSIQSAKTRPGADCGSDHELLIAKFRLKLKKVGKTTRPFRCKAQNNATQIVKPGSTLVETIQSNMEKTIVKKQKRIFWYRHFRYFIFVVMIFFRLLGYVLFYLQYINPDLLVDALPMVMSRETLTRLRDALFPFLTLEVEEVLPH", "length": 351, "header": "sp|Q32L59-1|TMC5B_BOVIN Isoform 1 of Transmembrane and coiled-coil domain-containing protein 5B OS=Bos taurus OX=9913 GN=TMCO5B PE=2 SV=1 CANONICAL=Q32L59-1" }, "isoforms": [ { "isoform_ac": "Q32L59-1", "url": "https://www.uniprot.org/uniprotkb/Q32L59/entry#Q32L59-1", "sequence": { "sequence": "MEEAGQDPLDDVRDVMEIPKLEITKQNLDSLNSDLEKDLQRMDEANQVLLKKIQEKEETIQSLERDITLSVRQAREREELDHRTAEKEAALRDLELETAKLEKNKEILSRSVVEVQKEISRKFKNVSLDKEALKQMLAELKVKLQKSTESCASQEKELVKIESDYQSVYQLCEDQAHYIKKYQEILRQMEKEKEMLLLEKEVQRWRSSIQSAKTRPGADCGSDHELLIAKFRLKLKKVGKTTRPFRCKAQNNATQIVKPGSTLVETIQSNMEKTIVKKQKRIFWYRHFRYFIFVVMIFFRLLGYVLFYLQYINPDLLVDALPMVMSRETLTRLRDALFPFLTLEVEEVLPH", "length": 351, "header": "sp|Q32L59-1|TMC5B_BOVIN Isoform 1 of Transmembrane and coiled-coil domain-containing protein 5B OS=Bos taurus OX=9913 GN=TMCO5B PE=2 SV=1 CANONICAL=Q32L59-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513290", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513290", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32L59", "url": "https://www.uniprot.org/uniprotkb/Q32L59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L59-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L59-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L59" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 252, "end_pos": 254 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L62-1", "uniprot_ac": "Q32L62", "uniprot_id": "HEMGN_BOVIN", "mass": { "chemical_mass": 51136.0, "monoisotopic_mass": 51136.0 }, "refseq": { "ac": "NP_001070523", "name": "hemogen", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070523" }, "gene_names": [ { "name": "HEMGN", "type": "recommended", "evidence": [ { "id": "Q32L62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ] }, { "name": "HEMGN", "type": "synonym", "evidence": [ { "id": "NP_001070523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070523" } ] } ], "protein_names": [ { "name": "Hemogen", "type": "recommended", "evidence": [ { "id": "Q32L62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L62/entry#names_and_taxonomy" } ] }, { "name": "Hemopoietic gene protein", "type": "synonym", "evidence": [ { "id": "Q32L62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L62/entry#names_and_taxonomy" } ] }, { "name": "hemogen", "type": "synonym", "evidence": [ { "id": "NP_001070523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070523" } ] }, { "name": "hemopoietic gene protein", "type": "synonym", "evidence": [ { "id": "NP_001070523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070523" } ] } ], "function": [ { "annotation": "Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEMGN", "url": "https://www.uniprot.org/uniprotkb/Q32L62", "locus": { "chromosome": "8", "start_pos": 63103270, "end_pos": 63121637, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032206", "url": "https://www.ensembl.org/id/ENSBTAG00000032206" } ] } } ], "crossref": [ { "id": "Q32L62", "url": "https://alphafold.ebi.ac.uk/entry/Q32L62", "database": "AlphaFoldDB", "categories": [] }, { "id": "767995", "url": "https://www.ncbi.nlm.nih.gov/gene/767995", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767995", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767995", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L62", "url": "https://www.orthodb.org/?gene=Q32L62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15993", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15993", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15993:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15993:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001070523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070523", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L62-1", "url": "https://www.uniprot.org/uniprotkb/Q32L62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLGKDQSLSKLHQTPDHHQEESHVPEVIGTWSLRNREQLRKRKAEAQEKQTSQWQYREKKHKRQRTGKRSERGRKRQQNTEMKVELPSQLEKEMMEKAPAPGEKEIEPPGSVTEVLLPAVSPQRVAPAKHLSEVGQESVTLQENSSEYQATAVQNQPSEICQDMAESEDLSPKMCQEIAIFQDQPFKMFRNMAQPEDVSPKTCQEDIAAKVLSSKTSEDTTDLEECSLEAHPKPDMPKASTLETYQKRPEPEEPDSETGQGIVETESFVSNTQQEMAVPKELATEIHQETVEPEHFSHKIYREIAMSKDPSHKTTQETSVPDKYPPEMYQETPGSEEYSLEIYQETTGPEAYAPEIYQETPGPEDLSTKTYKDKDVPKECFPKLYQEIGGPQDQDSKAHQEDAKDVYTFPQEMKENPKAEEPEIIEIPNVPQESNPENDIYSYVLF", "length": 447, "header": "sp|Q32L62-1|HEMGN_BOVIN Isoform 1 of Hemogen OS=Bos taurus OX=9913 GN=HEMGN PE=2 SV=1 CANONICAL=Q32L62-1" }, "isoforms": [ { "isoform_ac": "Q32L62-1", "url": "https://www.uniprot.org/uniprotkb/Q32L62/entry#Q32L62-1", "sequence": { "sequence": "MDLGKDQSLSKLHQTPDHHQEESHVPEVIGTWSLRNREQLRKRKAEAQEKQTSQWQYREKKHKRQRTGKRSERGRKRQQNTEMKVELPSQLEKEMMEKAPAPGEKEIEPPGSVTEVLLPAVSPQRVAPAKHLSEVGQESVTLQENSSEYQATAVQNQPSEICQDMAESEDLSPKMCQEIAIFQDQPFKMFRNMAQPEDVSPKTCQEDIAAKVLSSKTSEDTTDLEECSLEAHPKPDMPKASTLETYQKRPEPEEPDSETGQGIVETESFVSNTQQEMAVPKELATEIHQETVEPEHFSHKIYREIAMSKDPSHKTTQETSVPDKYPPEMYQETPGSEEYSLEIYQETTGPEAYAPEIYQETPGPEDLSTKTYKDKDVPKECFPKLYQEIGGPQDQDSKAHQEDAKDVYTFPQEMKENPKAEEPEIIEIPNVPQESNPENDIYSYVLF", "length": 447, "header": "sp|Q32L62-1|HEMGN_BOVIN Isoform 1 of Hemogen OS=Bos taurus OX=9913 GN=HEMGN PE=2 SV=1 CANONICAL=Q32L62-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "site_lbl": "Ser122" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "site_lbl": "Ser200" }, { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "site_lbl": "Thr217" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "site_lbl": "Ser89" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767995", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767995", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "pmid": "" }, { "name": "regulation of osteoblast differentiation", "id": "GO:0045667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045667", "evidence": [ { "database": "UniProtKB", "id": "Q32L62", "url": "https://www.uniprot.org/uniprotkb/Q32L62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 447, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L62" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 89, 122, 200, 217 ], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L63-1", "uniprot_ac": "Q32L63", "uniprot_id": "VTA1_BOVIN", "mass": { "chemical_mass": 34016.0, "monoisotopic_mass": 34016.0 }, "refseq": {}, "gene_names": [ { "name": "VTA1", "type": "recommended", "evidence": [ { "id": "Q32L63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ] } ], "protein_names": [ { "name": "Vacuolar protein sorting-associated protein VTA1 homolog", "type": "recommended", "evidence": [ { "id": "Q32L63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L63/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VTA1", "url": "https://www.uniprot.org/uniprotkb/Q32L63", "locus": { "chromosome": "9", "start_pos": 79700323, "end_pos": 79629610, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005851", "url": "https://www.ensembl.org/id/ENSBTAG00000005851" } ] } } ], "crossref": [ { "id": "Q32L63", "url": "https://alphafold.ebi.ac.uk/entry/Q32L63", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR023175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q32L63", "url": "https://www.orthodb.org/?gene=Q32L63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46009:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46009:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L63-1", "url": "https://www.uniprot.org/uniprotkb/Q32L63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEEYEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVTSNTIQPTPQTIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 307, "header": "sp|Q32L63-1|VTA1_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus OX=9913 GN=VTA1 PE=2 SV=1 CANONICAL=Q32L63-1" }, "isoforms": [ { "isoform_ac": "Q32L63-1", "url": "https://www.uniprot.org/uniprotkb/Q32L63/entry#Q32L63-1", "sequence": { "sequence": "MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEEYEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVTSNTIQPTPQTIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 307, "header": "sp|Q32L63-1|VTA1_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus OX=9913 GN=VTA1 PE=2 SV=1 CANONICAL=Q32L63-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 242, "start_aa": "Thr", "end_pos": 242, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr242", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ], "pmid": "" }, { "name": "late endosome to vacuole transport via multivesicular body sorting pathway", "id": "GO:0032511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032511", "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "Q32L63", "url": "https://www.uniprot.org/uniprotkb/Q32L63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L63" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 242 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L79-1", "uniprot_ac": "Q32L79", "uniprot_id": "INSL6_BOVIN", "mass": { "chemical_mass": 24001.0, "monoisotopic_mass": 24001.0 }, "refseq": { "ac": "NP_001070989", "name": "insulin-like peptide INSL6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989" }, "gene_names": [ { "name": "INSL6", "type": "recommended", "evidence": [ { "id": "Q32L79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L79" } ] }, { "name": "INSL6", "type": "synonym", "evidence": [ { "id": "NP_001070989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989" } ] } ], "protein_names": [ { "name": "Insulin-like peptide INSL6", "type": "recommended", "evidence": [ { "id": "Q32L79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L79/entry#names_and_taxonomy" } ] }, { "name": "Insulin-like peptide 6", "type": "synonym", "evidence": [ { "id": "Q32L79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L79/entry#names_and_taxonomy" } ] }, { "name": "insulin-like peptide 6", "type": "synonym", "evidence": [ { "id": "NP_001070989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989" } ] }, { "name": "insulin-like peptide INSL6 precursor", "type": "synonym", "evidence": [ { "id": "NP_001070989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989" } ] }, { "name": "insulin-like peptide INSL6", "type": "synonym", "evidence": [ { "id": "NP_001070989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989" } ] } ], "function": [ { "annotation": "May have a role in sperm development and fertilization.", "evidence": [ { "database": "UniProtKB", "id": "Q32L79", "url": "https://www.uniprot.org/uniprotkb/Q32L79#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L79", "url": "https://www.uniprot.org/uniprotkb/Q32L79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INSL6", "url": "https://www.uniprot.org/uniprotkb/Q32L79", "locus": { "chromosome": "8", "start_pos": 39362934, "end_pos": 39351712, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006651", "url": "https://www.ensembl.org/id/ENSBTAG00000006651" } ] } } ], "crossref": [ { "id": "Q32L79", "url": "https://alphafold.ebi.ac.uk/entry/Q32L79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006651", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006651", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "774023", "url": "https://www.ncbi.nlm.nih.gov/gene/774023", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:774023", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:774023", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SIACFPY", "url": "https://omabrowser.org/oma/group/SIACFPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L79", "url": "https://www.orthodb.org/?gene=Q32L79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12004", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12004", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12004:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12004:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070989", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L79", "url": "https://www.uniprot.org/uniprotkb/Q32L79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L79-1", "url": "https://www.uniprot.org/uniprotkb/Q32L79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRFLYLCLGLLLVRVSRELNDISRARRLCGQHLLHEIVKLCGDVNWSHVEKEKPFTQLLSQASEKVESFIPDRSESSQTTFPVWRRATNPVPTSASQEEAINNMKMQSLPEYQYKKANLPFKTRQEESSSSQDISPYIHEIIEFQKKNTNKIKTLSNLFWGNHPQRKRRGYSEKCCQKGCTKEELIIACLPYIDYENLRKHQQL", "length": 205, "header": "sp|Q32L79-1|INSL6_BOVIN Isoform 1 of Insulin-like peptide INSL6 OS=Bos taurus OX=9913 GN=INSL6 PE=2 SV=1 CANONICAL=Q32L79-1" }, "isoforms": [ { "isoform_ac": "Q32L79-1", "url": "https://www.uniprot.org/uniprotkb/Q32L79/entry#Q32L79-1", "sequence": { "sequence": "MPRFLYLCLGLLLVRVSRELNDISRARRLCGQHLLHEIVKLCGDVNWSHVEKEKPFTQLLSQASEKVESFIPDRSESSQTTFPVWRRATNPVPTSASQEEAINNMKMQSLPEYQYKKANLPFKTRQEESSSSQDISPYIHEIIEFQKKNTNKIKTLSNLFWGNHPQRKRRGYSEKCCQKGCTKEELIIACLPYIDYENLRKHQQL", "length": 205, "header": "sp|Q32L79-1|INSL6_BOVIN Isoform 1 of Insulin-like peptide INSL6 OS=Bos taurus OX=9913 GN=INSL6 PE=2 SV=1 CANONICAL=Q32L79-1" }, "locus": { "chromosome": "8", "start_pos": 39362867, "end_pos": 39351794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008739.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008739.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008739.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008739.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:774023", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:774023", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SK47-1", "protein_name": "Insulin like 6", "gene_name": "INSL6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPRLLGLCVLWLGLPLVRFSRELNDISRARKLCGRHLLKEIVRLCGNVSWSQFEEENPLTHLLSQAEQVETFIPDRLESSQTTFSVWGRGSRQVSTSASQEEAINNLKMKSLHEYQYKKANLPFKTRQEIFSSTQDINPYIREIVEFQKKNTNNFKTLSNLFWGYHPQRKRRGYSEKCCLKGCTKEELSIACLPYIDYKNLKKEASAIVTEIY", "length": 213 }, "evidence": [ { "id": "Q32L79", "url": "https://omabrowser.org/oma/group/Q32L79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9QY05-1", "protein_name": "Insulin-like peptide INSL6", "gene_name": "Insl6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKQLCCSCLLWLGLLLTPFSREEEEESRPRKLCGRHLLIEVIKLCGQSDWSRFEMEEQSPMTQFFPHYSRKGKAFNPHPSSSAWRRFTNPVPAGVSQKKGTHTWEPQSLPDYQFEKTELLPKARVFSYHSGKPYVKSVQLQKKSTNKMNTFRSLFWGNHSQRKRRGFADKCCVIGCTKEEMAVACLPFVDF", "length": 191 }, "evidence": [ { "id": "Q32L79", "url": "https://omabrowser.org/oma/group/Q32L79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9WV41-1", "protein_name": "Insulin-like peptide INSL6", "gene_name": "Insl6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKQLCCSCLLWLGLLLAPFSQEQEEVTSPTKLCGRDLLVEVIKLCGQNDWSRFSMEEQSPMTELVPQYTRKVKTFNPHRSSSSWGRFTNPGVSQKKATHTWESQSLPNYQLKKEELLPKTGVHSYHGGKPYVKSVKFQKKNTDKMSTFSGLFWGNHPQRKRRGFADKCCAIGCSKEELAVACLPFVDF", "length": 188 }, "evidence": [ { "id": "Q32L79", "url": "https://omabrowser.org/oma/group/Q32L79/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y581-1", "protein_name": "Insulin-like peptide INSL6", "gene_name": "INSL6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRLLRLSLLWLGLLLVRFSRELSDISSARKLCGRYLVKEIEKLCGHANWSQFRFEEETPFSRLIAQASEKVEAYSPYQFESPQTASPARGRGTNPVSTSWEEAVNSWEMQSLPEYKDKKGYSPLGKTREFSSSHNINVYIHENAKFQKKRRNKIKTLSNLFWGHHPQRKRRGYSEKCCLTGCTKEELSIACLPYIDFKRLKEKRSSLVTKIY", "length": 213 }, "evidence": [ { "id": "Q32L79", "url": "https://omabrowser.org/oma/group/Q32L79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q32L79", "url": "https://www.uniprot.org/uniprotkb/Q32L79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q32L79", "url": "https://www.uniprot.org/uniprotkb/Q32L79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L79-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L79-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L79" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L83-1", "uniprot_ac": "Q32L83", "uniprot_id": "BRI3_BOVIN", "mass": { "chemical_mass": 13560.0, "monoisotopic_mass": 13560.0 }, "refseq": { "ac": "NP_001035673", "name": "membrane protein BRI3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035673" }, "gene_names": [ { "name": "BRI3", "type": "recommended", "evidence": [ { "id": "Q32L83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L83" } ] }, { "name": "BRI3", "type": "synonym", "evidence": [ { "id": "NP_001035673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035673" } ] } ], "protein_names": [ { "name": "Membrane protein BRI3", "type": "recommended", "evidence": [ { "id": "Q32L83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#names_and_taxonomy" } ] }, { "name": "Brain protein I3", "type": "synonym", "evidence": [ { "id": "Q32L83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#names_and_taxonomy" } ] }, { "name": "membrane protein BRI3", "type": "synonym", "evidence": [ { "id": "NP_001035673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035673" } ] } ], "function": [ { "annotation": "Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.", "evidence": [ { "database": "UniProtKB", "id": "Q32L83", "url": "https://www.uniprot.org/uniprotkb/Q32L83#function" }, { "database": "UniProtKB", "id": "O95415", "url": "https://www.uniprot.org/uniprotkb/O95415#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L83", "url": "https://www.uniprot.org/uniprotkb/Q32L83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRI3", "url": "https://www.uniprot.org/uniprotkb/Q32L83", "locus": { "chromosome": "25", "start_pos": 37720255, "end_pos": 37750355, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022825", "url": "https://www.ensembl.org/id/ENSBTAG00000022825" } ] } } ], "crossref": [ { "id": "Q32L83", "url": "https://alphafold.ebi.ac.uk/entry/Q32L83", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022825", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022825", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615390", "url": "https://www.ncbi.nlm.nih.gov/gene/615390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615390", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615390", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEYGPQQ", "url": "https://omabrowser.org/oma/group/YEYGPQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5F1", "url": "https://www.orthodb.org/?gene=A0A3Q1M5F1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32L83", "url": "https://www.orthodb.org/?gene=Q32L83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13551:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13551:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10164", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10164", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5F1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5F1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5F1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SID5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SID5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI50", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L83", "url": "https://www.uniprot.org/uniprotkb/Q32L83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L83-1", "url": "https://www.uniprot.org/uniprotkb/Q32L83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGEFACAPHGYGAIAAAPPPPYPYLVTGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT", "length": 124, "header": "sp|Q32L83-1|BRI3_BOVIN Isoform 1 of Membrane protein BRI3 OS=Bos taurus OX=9913 GN=BRI3 PE=2 SV=1 CANONICAL=Q32L83-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5F1-1", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#A0A3Q1M5F1-1", "sequence": { "sequence": "MPPRPTLPHSSRPSARNGPGPGAFCVPHSCRPQPPALFYWSVRALFLAPSAGSLLPPRGPLLKPAMSTVQAAGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT", "length": 150, "header": "tr|A0A3Q1M5F1-1|A0A3Q1M5F1_BOVIN Computationally mapped isoform of Membrane protein BRI3 OS=Bos taurus OX=9913 GN=BRI3 PE=3 SV=2 CANONICAL=Q32L83-1" }, "locus": { "chromosome": "25", "start_pos": 37750156, "end_pos": 37736379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081431.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081431.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063500.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063500.2" } ] } }, { "isoform_ac": "A0AAA9SID5-1", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#A0AAA9SID5-1", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGEFACAPHGYGAIAAAPPPPYPYLVTGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCSCTRWTACGLSLAVPCVTAMTFTPKGPVRPPHAQCHHSLEVLDAKLQF", "length": 128, "header": "tr|A0AAA9SID5-1|A0AAA9SID5_BOVIN Computationally mapped isoform of Membrane protein BRI3 OS=Bos taurus OX=9913 GN=BRI3 PE=3 SV=1 CANONICAL=Q32L83-1" }, "locus": { "chromosome": "25", "start_pos": 37742796, "end_pos": 37720426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111308.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111308.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083674.1" } ] } }, { "isoform_ac": "A0AAF6ZI50-1", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#A0AAF6ZI50-1", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGEFACAPHGYGAIAAAPPPPYPYLVTGGPGPGPGRGPGAWERTSGGVPPRPLTPKPTFLRTWRRRGARSRGDPGVRTVQGVGDDAVLGTGGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT", "length": 188, "header": "tr|A0AAF6ZI50-1|A0AAF6ZI50_BOVIN Computationally mapped isoform of Membrane protein BRI3 OS=Bos taurus OX=9913 GN=BRI3 PE=3 SV=1 CANONICAL=Q32L83-1" }, "locus": { "chromosome": "25", "start_pos": 37742796, "end_pos": 37736379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055646.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055646.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048073.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048073.4" } ] } }, { "isoform_ac": "Q32L83-1", "url": "https://www.uniprot.org/uniprotkb/Q32L83/entry#Q32L83-1", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGEFACAPHGYGAIAAAPPPPYPYLVTGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT", "length": 124, "header": "sp|Q32L83-1|BRI3_BOVIN Isoform 1 of Membrane protein BRI3 OS=Bos taurus OX=9913 GN=BRI3 PE=2 SV=1 CANONICAL=Q32L83-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615390", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615390", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BJT3-1", "protein_name": "Membrane protein BRI3", "gene_name": "BRI3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGDFACGPHGYGAIPAAAPPPPYPYLVTGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT", "length": 125 }, "evidence": [ { "id": "Q32L83", "url": "https://omabrowser.org/oma/group/Q32L83/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E7FAC9-1", "protein_name": "Membrane protein BRI3", "gene_name": "bri3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDTKPLLQDRPPAYNTVPSAYDYGSIPAAGAPAAGFQPPAPPPYQGFPAAASGYPAAPAPAAAQPAFSTYTIVQPSVVVVGGCPACRVGVLEDDFTCLGIMCAIFFFPLGILFCLALRQRRCPNCGATFG", "length": 130 }, "evidence": [ { "id": "Q32L83", "url": "https://omabrowser.org/oma/group/Q32L83/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O95415-1", "protein_name": "Membrane protein BRI3", "gene_name": "BRI3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIHSRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNCGATFA", "length": 125 }, "evidence": [ { "id": "Q32L83", "url": "https://omabrowser.org/oma/group/Q32L83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P28662-1", "protein_name": "Membrane protein BRI3", "gene_name": "Bri3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPTAPPPPPYPYLVTGIPTSHPRVYNIHSRTVTRYPANSIVVVGGCPVCRVGVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVFT", "length": 125 }, "evidence": [ { "id": "Q32L83", "url": "https://omabrowser.org/oma/group/Q32L83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5PPK1-1", "protein_name": "Membrane protein BRI3", "gene_name": "Bri3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPTAPPPPPYPYLVTGIPTSHPRVYNIHSRAVTRYPANSIVVVGGCPVCRVGVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVFT", "length": 125 }, "evidence": [ { "id": "Q32L83", "url": "https://omabrowser.org/oma/group/Q32L83/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q32L83", "url": "https://www.uniprot.org/uniprotkb/Q32L83" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q32L83", "url": "https://www.uniprot.org/uniprotkb/Q32L83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L83-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 124, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L83-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L83" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L86-1", "uniprot_ac": "Q32L86", "uniprot_id": "T126A_BOVIN", "mass": { "chemical_mass": 21536.0, "monoisotopic_mass": 21536.0 }, "refseq": { "ac": "NP_001032697", "name": "transmembrane protein 126A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032697" }, "gene_names": [ { "name": "TMEM126A", "type": "recommended", "evidence": [ { "id": "Q32L86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ] }, { "name": "TMEM126A", "type": "synonym", "evidence": [ { "id": "NP_001032697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032697" } ] } ], "protein_names": [ { "name": "Transmembrane protein 126A", "type": "recommended", "evidence": [ { "id": "Q32L86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L86/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 126A", "type": "synonym", "evidence": [ { "id": "NP_001032697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032697" } ] } ], "function": [ { "annotation": "Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86#function" }, { "database": "UniProtKB", "id": "Q9H061", "url": "https://www.uniprot.org/uniprotkb/Q9H061#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM126A", "url": "https://www.uniprot.org/uniprotkb/Q32L86", "locus": { "chromosome": "29", "start_pos": 9897293, "end_pos": 9906615, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000451", "url": "https://www.ensembl.org/id/ENSBTAG00000000451" } ] } } ], "crossref": [ { "id": "Q32L86", "url": "https://alphafold.ebi.ac.uk/entry/Q32L86", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000451", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000451", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529762", "url": "https://www.ncbi.nlm.nih.gov/gene/529762", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529762", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529762", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDLHCET", "url": "https://omabrowser.org/oma/group/GDLHCET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L86", "url": "https://www.orthodb.org/?gene=Q32L86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032697", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L86-1", "url": "https://www.uniprot.org/uniprotkb/Q32L86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENHEPDGTIIKENLTDIIARKINQLPEAERNLLENGSTYVGLNAALCGLIANSLFRRILHVTQARIAAGLPMAVIPFLTANVSYKGFVSLPLNTGDLQCETCTVTRGGLVGLVFGGLYPVFLAIPVNGGLAARYNSALLPEKGNILNYWIRISKPVFRKMLFPILLQTGFAAYLGSRQYKLLIKALQLPEPGLEIE", "length": 197, "header": "sp|Q32L86-1|T126A_BOVIN Isoform 1 of Transmembrane protein 126A OS=Bos taurus OX=9913 GN=TMEM126A PE=2 SV=1 CANONICAL=Q32L86-1" }, "isoforms": [ { "isoform_ac": "Q32L86-1", "url": "https://www.uniprot.org/uniprotkb/Q32L86/entry#Q32L86-1", "sequence": { "sequence": "MENHEPDGTIIKENLTDIIARKINQLPEAERNLLENGSTYVGLNAALCGLIANSLFRRILHVTQARIAAGLPMAVIPFLTANVSYKGFVSLPLNTGDLQCETCTVTRGGLVGLVFGGLYPVFLAIPVNGGLAARYNSALLPEKGNILNYWIRISKPVFRKMLFPILLQTGFAAYLGSRQYKLLIKALQLPEPGLEIE", "length": 197, "header": "sp|Q32L86-1|T126A_BOVIN Isoform 1 of Transmembrane protein 126A OS=Bos taurus OX=9913 GN=TMEM126A PE=2 SV=1 CANONICAL=Q32L86-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529762", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529762", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QM83-1", "protein_name": "Transmembrane protein 126A", "gene_name": "tmem126a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTDNSMTMRDASQGLTSSRMRIIEMLNKKFEKLPESDRKMLSRGPLYLAANAGIAGMVANSFYRRVLHVTQGLFTSSLPMAVLPFVTTAALYTATVTTPLLSGDLNCPTCALIRGALVGVVGGGIYPILLALPVNAGLAARYNSAPMPEKGNIIRFWTNLSKPVVKKMSFVLVLQCVIGTFLSSRHFEIYLKMLRMPDSDSEQLNG", "length": 206 }, "evidence": [ { "id": "Q32L86", "url": "https://omabrowser.org/oma/group/Q32L86/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XRM3-1", "protein_name": "Transmembrane protein 126A", "gene_name": "TMEM126A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTGREFLELDSPQRTLYLERVKRMEIIHKLLNELPKSDQTEKITPWLYPSYYSVVALCRICCACTQLQTRLLPQNWELSGMNLCNHGSYFLAGNASLCGLTANNFFRKILNIRKAAIISALPMAVIPFISTVAVYDAFLREPLFSGELDCQVCAVVRGGLIGAVVGSLYPIFMAVPVNGSLAARYSSSPLPGKENLLRFWLSVSQPVFRKMRFGVLIQVLTGVFLATKHHGIYVKVLEQMKPSRDPEELQA", "length": 251 }, "evidence": [ { "id": "Q32L86", "url": "https://omabrowser.org/oma/group/Q32L86/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LJK4-1", "protein_name": "Transmembrane protein 126A", "gene_name": "TMEM126A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENHEPDDTIKENLIDTITRKTNQLPEAERNLLESGSTYIGINAALCGLIANSHFRRILHVTQARIAAGLPMAVIPFLTAHVSYQGFISLPLSTGDLHCETCTIIRGGLVGLVFGGLYPVFLALPVNGGLAARYNSALLPEKGNILNYWMRISKPVFRKMLFPILLQTGFGAYLGSRQYKVLIKALQLPEPGLEMH", "length": 196 }, "evidence": [ { "id": "Q32L86", "url": "https://omabrowser.org/oma/group/Q32L86/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D8Y1-1", "protein_name": "Transmembrane protein 126A", "gene_name": "Tmem126a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESHKPSTSKDDLILNIISRKIKQLPESDRNLLEYGSAYIGLNAAFGGLIANSLFRRILNVTQARLASSLPMAVIPFLTANLSYQSLVSLPLSTGDLNCETCTTTRGALVGLVMGGLYPILLAIPVNGGLAARYESSPLPQRGNIFNYWITVSKPVFRKMLFPTLLQTVFASYLGSRQYKLLIKALQLPEPDLEIH", "length": 196 }, "evidence": [ { "id": "Q32L86", "url": "https://omabrowser.org/oma/group/Q32L86/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H061-1", "protein_name": "Transmembrane protein 126A", "gene_name": "TMEM126A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENHKSNNKENITIVDISRKINQLPEAERNLLENGSVYVGLNAALCGLIANSLFRRILNVTKARIAAGLPMAGIPFLTTDLTYRCFVSFPLNTGDLDCETCTITRSGLTGLVIGGLYPVFLAIPVNGGLAARYQSALLPHKGNILSYWIRTSKPVFRKMLFPILLQTMFSAYLGSEQYKLLIKALQLSEPGKEIH", "length": 195 }, "evidence": [ { "id": "Q32L86", "url": "https://omabrowser.org/oma/group/Q32L86/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "pmid": "" }, { "name": "mitochondrial protein quality control", "id": "GO:0141164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141164", "evidence": [ { "database": "UniProtKB", "id": "Q32L86", "url": "https://www.uniprot.org/uniprotkb/Q32L86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L86-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L86-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L86" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L89-1", "uniprot_ac": "Q32L89", "uniprot_id": "PIGH_BOVIN", "mass": { "chemical_mass": 21006.0, "monoisotopic_mass": 21006.0 }, "refseq": {}, "gene_names": [ { "name": "PIGH", "type": "recommended", "evidence": [ { "id": "Q32L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L89" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit H", "type": "recommended", "evidence": [ { "id": "Q32L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L89/entry#names_and_taxonomy" } ] }, { "name": "PIG-H", "type": "synonym", "evidence": [ { "id": "Q32L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L89/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class H protein", "type": "synonym", "evidence": [ { "id": "Q32L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L89/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32L89", "url": "https://www.uniprot.org/uniprotkb/Q32L89#function" }, { "database": "UniProtKB", "id": "Q14442", "url": "https://www.uniprot.org/uniprotkb/Q14442#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L89", "url": "https://www.uniprot.org/uniprotkb/Q32L89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGH", "url": "https://www.uniprot.org/uniprotkb/Q32L89", "locus": { "chromosome": "10", "start_pos": 79462217, "end_pos": 79474711, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018299", "url": "https://www.ensembl.org/id/ENSBTAG00000018299" } ] } } ], "crossref": [ { "id": "Q32L89", "url": "https://alphafold.ebi.ac.uk/entry/Q32L89", "database": "AlphaFoldDB", "categories": [] }, { "id": "515306", "url": "https://www.ncbi.nlm.nih.gov/gene/515306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515306", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L89", "url": "https://www.orthodb.org/?gene=Q32L89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15231:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15231:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L89", "url": "https://www.uniprot.org/uniprotkb/Q32L89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L89-1", "url": "https://www.uniprot.org/uniprotkb/Q32L89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDERSLSDICGGRLALHRRYYSPSCLEFCLSCPRISLRSITAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDHETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDVIINEAIYMQKVIYYLCILLKDPVEPHGISQVVPIFQSAKPRLDCLIEVYRSCQEILAHQKAASTSP", "length": 188, "header": "sp|Q32L89-1|PIGH_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit H OS=Bos taurus OX=9913 GN=PIGH PE=2 SV=1 CANONICAL=Q32L89-1" }, "isoforms": [ { "isoform_ac": "Q32L89-1", "url": "https://www.uniprot.org/uniprotkb/Q32L89/entry#Q32L89-1", "sequence": { "sequence": "MEDERSLSDICGGRLALHRRYYSPSCLEFCLSCPRISLRSITAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDHETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDVIINEAIYMQKVIYYLCILLKDPVEPHGISQVVPIFQSAKPRLDCLIEVYRSCQEILAHQKAASTSP", "length": 188, "header": "sp|Q32L89-1|PIGH_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit H OS=Bos taurus OX=9913 GN=PIGH PE=2 SV=1 CANONICAL=Q32L89-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515306", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515306", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "id": "GO:0000506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000506", "evidence": [ { "database": "UniProtKB", "id": "Q32L89", "url": "https://www.uniprot.org/uniprotkb/Q32L89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "Q32L89", "url": "https://www.uniprot.org/uniprotkb/Q32L89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L89-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L89-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L89" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L91-1", "uniprot_ac": "Q32L91", "uniprot_id": "ACL7B_BOVIN", "mass": { "chemical_mass": 45563.0, "monoisotopic_mass": 45563.0 }, "refseq": { "ac": "NP_001069165", "name": "actin-like protein 7B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069165" }, "gene_names": [ { "name": "ACTL7B", "type": "recommended", "evidence": [ { "id": "Q32L91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ] }, { "name": "ACTL7B", "type": "synonym", "evidence": [ { "id": "NP_001069165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069165" } ] } ], "protein_names": [ { "name": "Actin-like protein 7B", "type": "recommended", "evidence": [ { "id": "Q32L91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L91/entry#names_and_taxonomy" } ] }, { "name": "actin-like protein 7B", "type": "synonym", "evidence": [ { "id": "NP_001069165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069165" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTL7B", "url": "https://www.uniprot.org/uniprotkb/Q32L91", "locus": { "chromosome": "8", "start_pos": 98461592, "end_pos": 98464193, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019467", "url": "https://www.ensembl.org/id/ENSBTAG00000019467" } ] } } ], "crossref": [ { "id": "Q32L91", "url": "https://alphafold.ebi.ac.uk/entry/Q32L91", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019467", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019467", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515059", "url": "https://www.ncbi.nlm.nih.gov/gene/515059", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q32L91", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q32L91*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515059", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515059", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDCVQNI", "url": "https://omabrowser.org/oma/group/WDCVQNI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L91", "url": "https://www.orthodb.org/?gene=Q32L91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069165", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L91-1", "url": "https://www.uniprot.org/uniprotkb/Q32L91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRNSSSPKPMGTAQGDPGEAGTLPGPDAGIRDTSSATQLKMKPKKVRKIKALITDLGSQYCKCGYAGEPRPTYFISSTVGKRYSEAADSGDTRKETYVGHELLNMEAPLKLINPLKYGIVVDWDCIQSIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLLQLLNEAGHKFTDDHLHIIEHIKKKCCYSALKPEEELSLCLEDLRVDYELPDGKLISIGQERFQCAEMLFKPTLVGSNQPGLPELTAACLNRCQEAGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSAAIYSKC", "length": 417, "header": "sp|Q32L91-1|ACL7B_BOVIN Isoform 1 of Actin-like protein 7B OS=Bos taurus OX=9913 GN=ACTL7B PE=2 SV=1 CANONICAL=Q32L91-1" }, "isoforms": [ { "isoform_ac": "Q32L91-1", "url": "https://www.uniprot.org/uniprotkb/Q32L91/entry#Q32L91-1", "sequence": { "sequence": "MATRNSSSPKPMGTAQGDPGEAGTLPGPDAGIRDTSSATQLKMKPKKVRKIKALITDLGSQYCKCGYAGEPRPTYFISSTVGKRYSEAADSGDTRKETYVGHELLNMEAPLKLINPLKYGIVVDWDCIQSIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLLQLLNEAGHKFTDDHLHIIEHIKKKCCYSALKPEEELSLCLEDLRVDYELPDGKLISIGQERFQCAEMLFKPTLVGSNQPGLPELTAACLNRCQEAGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSAAIYSKC", "length": 417, "header": "sp|Q32L91-1|ACL7B_BOVIN Isoform 1 of Actin-like protein 7B OS=Bos taurus OX=9913 GN=ACTL7B PE=2 SV=1 CANONICAL=Q32L91-1" }, "locus": { "chromosome": "8", "start_pos": 98461593, "end_pos": 98461592, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025932.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025932.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000054716.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "site_lbl": "Ser8" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515059", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515059", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SP30-1", "protein_name": "Actin like 7B", "gene_name": "ACTL7B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATRNNPSPMPMGTAQGDPGEAGTLPGPDAGIRDTSSATQLKTKPKKVRKIKALIIDLGSQYCKCGYAGEPRPTYFISSTVGKRYSEGADAGDTRKETYVGHELLNMEAPLKLINPLKYGIVVDWDCVQNIWEYIFHTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFEAFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLLQLLNEAGHTFTDDHLHIIEHIKKKCCYSALKPEEELGLRLEELRVDYELPDGKLITIGQERFQCAEMLFKPTLVGSNQPGLPALTAACLSRCQEAGFKEEMAANVLLCGGCTMLDGFPERFQRELCLLCPGDSPAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSAAIYTKC", "length": 417 }, "evidence": [ { "id": "Q32L91", "url": "https://omabrowser.org/oma/group/Q32L91/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4QR76-1", "protein_name": "Actin-like protein 7B", "gene_name": "Actl7b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATKNNPSPKPMGTAQGDPGEAGTLPAPEAGIRDTGSTQLKAKPKKIRKIKALVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDTFKETYVGHELLNMEASLKLVNPLKHGVVVDWDCIQNIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELMFETFGIPAMHVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKFSDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELHVDYELPDGKVITIGQERFRCSEMLFKPSLVGSTQPGLPELTATCLDRCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPTVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC", "length": 417 }, "evidence": [ { "id": "Q32L91", "url": "https://omabrowser.org/oma/group/Q32L91/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QY83-1", "protein_name": "Actin-like protein 7B", "gene_name": "Actl7b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATKNSPSPKPMGTAQGDPGEAGTLPAPEAAGIRDTGSTQLKTKPKKIRKIKALVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDNFKETYVGHELLNMEASLKLVNPLKHGVVVDWDCIQNIWEYIFHTAMKIMPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAMHVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKFSDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELHVDYELPDGKIITIGQERFRCSEMLFKPSLVGCTQPGLPELTATCLARCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPTVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC", "length": 418 }, "evidence": [ { "id": "Q32L91", "url": "https://omabrowser.org/oma/group/Q32L91/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y614-1", "protein_name": "Actin-like protein 7B", "gene_name": "ACTL7B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATRNSPMPLGTAQGDPGEAGTRPGPDASLRDTGAATQLKMKPRKVHKIKAVIIDLGSQYCKCGYAGEPRPTYFISSTVGKRCPEAADAGDTRKWTLVGHELLNTEAPLKLVNPLKHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAGHAFTDDHLHIIEHIKKKCCYAAFLPEEELGLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSLAGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSVAIYSKC", "length": 415 }, "evidence": [ { "id": "Q32L91", "url": "https://omabrowser.org/oma/group/Q32L91/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q32L91", "url": "https://www.uniprot.org/uniprotkb/Q32L91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L91-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 417, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L91-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L91" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 8 ], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LA4-1", "uniprot_ac": "Q32LA4", "uniprot_id": "UPP_BOVIN", "mass": { "chemical_mass": 33355.0, "monoisotopic_mass": 33355.0 }, "refseq": { "ac": "NP_001069713", "name": "uracil phosphoribosyltransferase homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" }, "gene_names": [ { "name": "UPRT", "type": "recommended", "evidence": [ { "id": "Q32LA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ] }, { "name": "UPRT", "type": "synonym", "evidence": [ { "id": "NP_001069713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" } ] } ], "protein_names": [ { "name": "Uracil phosphoribosyltransferase homolog", "type": "recommended", "evidence": [ { "id": "Q32LA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LA4/entry#names_and_taxonomy" } ] }, { "name": "UMP pyrophosphorylase", "type": "synonym", "evidence": [ { "id": "NP_001069713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" } ] }, { "name": "UPRTase", "type": "synonym", "evidence": [ { "id": "NP_001069713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" } ] }, { "name": "uracil phosphoribosyltransferase (FUR1) homolog", "type": "synonym", "evidence": [ { "id": "NP_001069713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" } ] }, { "name": "uracil phosphoribosyltransferase homolog", "type": "synonym", "evidence": [ { "id": "NP_001069713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPRT", "url": "https://www.uniprot.org/uniprotkb/Q32LA4", "locus": { "chromosome": "X", "start_pos": 75911721, "end_pos": 75941848, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004549", "url": "https://www.ensembl.org/id/ENSBTAG00000004549" } ] } } ], "crossref": [ { "id": "Q32LA4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540851", "url": "https://www.ncbi.nlm.nih.gov/gene/540851", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540851", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540851", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LA4", "url": "https://www.orthodb.org/?gene=Q32LA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF14681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069713", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LA4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTQNPEPQQAGDLILAHAGGNSDSAATLTLLSGHAHSSVPAELDPQASGGATFNSENNGGTGNYDAPASDSLLGDCEISRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYEECMVTTPTGFKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 306, "header": "sp|Q32LA4-1|UPP_BOVIN Isoform 1 of Uracil phosphoribosyltransferase homolog OS=Bos taurus OX=9913 GN=UPRT PE=2 SV=1 CANONICAL=Q32LA4-1" }, "isoforms": [ { "isoform_ac": "Q32LA4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LA4/entry#Q32LA4-1", "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTQNPEPQQAGDLILAHAGGNSDSAATLTLLSGHAHSSVPAELDPQASGGATFNSENNGGTGNYDAPASDSLLGDCEISRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYEECMVTTPTGFKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 306, "header": "sp|Q32LA4-1|UPP_BOVIN Isoform 1 of Uracil phosphoribosyltransferase homolog OS=Bos taurus OX=9913 GN=UPRT PE=2 SV=1 CANONICAL=Q32LA4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540851", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540851", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ribosylnicotinamide kinase activity", "id": "GO:0050262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050262", "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "pmid": "" }, { "name": "nicotinate riboside kinase activity", "id": "GO:0061769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061769", "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32LA4", "url": "https://www.uniprot.org/uniprotkb/Q32LA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LA4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB0-1", "uniprot_ac": "Q32LB0", "uniprot_id": "WDR70_BOVIN", "mass": { "chemical_mass": 72641.0, "monoisotopic_mass": 72641.0 }, "refseq": { "ac": "NP_001069706", "name": "WD repeat-containing protein 70", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069706" }, "gene_names": [ { "name": "WDR70", "type": "recommended", "evidence": [ { "id": "Q32LB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ] }, { "name": "WDR70", "type": "synonym", "evidence": [ { "id": "NP_001069706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069706" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 70", "type": "recommended", "evidence": [ { "id": "Q32LB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB0/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 70", "type": "synonym", "evidence": [ { "id": "NP_001069706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069706" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR70", "url": "https://www.uniprot.org/uniprotkb/Q32LB0", "locus": { "chromosome": "20", "start_pos": 36690359, "end_pos": 36974107, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033095", "url": "https://www.ensembl.org/id/ENSBTAG00000033095" } ] } } ], "crossref": [ { "id": "Q32LB0", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "540724", "url": "https://www.ncbi.nlm.nih.gov/gene/540724", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540724", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540724", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LB0", "url": "https://www.orthodb.org/?gene=Q32LB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16017", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16017", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16017:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16017:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069706", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERPGPSDGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITIKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 652, "header": "sp|Q32LB0-1|WDR70_BOVIN Isoform 1 of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=2 SV=1 CANONICAL=Q32LB0-1" }, "isoforms": [ { "isoform_ac": "Q32LB0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB0/entry#Q32LB0-1", "sequence": { "sequence": "MERPGPSDGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITIKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 652, "header": "sp|Q32LB0-1|WDR70_BOVIN Isoform 1 of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=2 SV=1 CANONICAL=Q32LB0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 577, "end_pos": 577, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "site_lbl": "Thr577" }, { "start_pos": 619, "end_pos": 619, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "site_lbl": "Ser619" }, { "start_pos": 636, "end_pos": 636, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "site_lbl": "Ser636" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540724", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540724", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "Q32LB0", "url": "https://www.uniprot.org/uniprotkb/Q32LB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 652, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 577, 619, 636 ], "sequon_annotation_sites": [ { "start_pos": 351, "end_pos": 353 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 500, "end_pos": 502 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB6-1", "uniprot_ac": "Q32LB6", "uniprot_id": "TAF1D_BOVIN", "mass": { "chemical_mass": 32071.0, "monoisotopic_mass": 32071.0 }, "refseq": { "ac": "NP_001032675", "name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" }, "gene_names": [ { "name": "TAF1D", "type": "recommended", "evidence": [ { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ] }, { "name": "JOSD3", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" }, { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ] }, { "name": "TAF1D", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" } ] } ], "protein_names": [ { "name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "type": "recommended", "evidence": [ { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6/entry#names_and_taxonomy" } ] }, { "name": "Josephin domain containing 3", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" } ] }, { "name": "TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" } ] }, { "name": "TATA box-binding protein-associated factor 1D", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" }, { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6/entry#names_and_taxonomy" } ] }, { "name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" } ] }, { "name": "TBP-associated factor 1D", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" }, { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6/entry#names_and_taxonomy" } ] }, { "name": "Transcription initiation factor SL1/TIF-IB subunit D", "type": "synonym", "evidence": [ { "id": "Q32LB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB6/entry#names_and_taxonomy" } ] }, { "name": "transcription initiation factor SL1/TIF-IB subunit D", "type": "synonym", "evidence": [ { "id": "NP_001032675", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675" } ] } ], "function": [ { "annotation": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAF1D", "url": "https://www.uniprot.org/uniprotkb/Q32LB6", "locus": { "chromosome": "29", "start_pos": 1086765, "end_pos": 1080813, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003545", "url": "https://www.ensembl.org/id/ENSBTAG00000003545" } ] } } ], "crossref": [ { "id": "Q32LB6", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003545", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003545", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505533", "url": "https://www.ncbi.nlm.nih.gov/gene/505533", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505533", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505533", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKFVHTP", "url": "https://omabrowser.org/oma/group/RKFVHTP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LB6", "url": "https://www.orthodb.org/?gene=Q32LB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14562", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14562", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14562:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14562:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15333", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15333", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5250924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73762", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73772", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73863", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73863", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032675", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSLNYTTACDSAVETENQSDNSSSGSSLFKTQCVPVPPKRRQRNTIRKFVHIPKNTQATESSSDSSIEPRPLTLKAIFERFKNKKRKRKKKKYKPTGRSVGRPKGRRTTRYSQITEKQFKDKRPGFPFLESENGRKPLPWRKILTFEQAVARGFFNYLEKLKYEYYLKESLKQMNVAEDLEKDDLDSRRYRYLDDDGSLSPIEESAAEEETAANLEHDECDIKLVENSYFIISSEFPKKKQNVHLDQEEYTEETALLKKRTSKSKHWIEDKMA", "length": 274, "header": "sp|Q32LB6-1|TAF1D_BOVIN Isoform 1 of TATA box-binding protein-associated factor RNA polymerase I subunit D OS=Bos taurus OX=9913 GN=TAF1D PE=2 SV=1 CANONICAL=Q32LB6-1" }, "isoforms": [ { "isoform_ac": "Q32LB6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB6/entry#Q32LB6-1", "sequence": { "sequence": "MDSLNYTTACDSAVETENQSDNSSSGSSLFKTQCVPVPPKRRQRNTIRKFVHIPKNTQATESSSDSSIEPRPLTLKAIFERFKNKKRKRKKKKYKPTGRSVGRPKGRRTTRYSQITEKQFKDKRPGFPFLESENGRKPLPWRKILTFEQAVARGFFNYLEKLKYEYYLKESLKQMNVAEDLEKDDLDSRRYRYLDDDGSLSPIEESAAEEETAANLEHDECDIKLVENSYFIISSEFPKKKQNVHLDQEEYTEETALLKKRTSKSKHWIEDKMA", "length": 274, "header": "sp|Q32LB6-1|TAF1D_BOVIN Isoform 1 of TATA box-binding protein-associated factor RNA polymerase I subunit D OS=Bos taurus OX=9913 GN=TAF1D PE=2 SV=1 CANONICAL=Q32LB6-1" }, "locus": { "chromosome": "29", "start_pos": 1086496, "end_pos": 1082481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004611.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004611.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004611.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004611.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "site_lbl": "Ser132" }, { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "site_lbl": "Ser20" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "site_lbl": "Ser229" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505533", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505533", "resource": "KEGG Pathway" }, { "id": "R-BTA-5250924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250924", "resource": "Reactome", "description": "B-WICH complex positively regulates rRNA expression" }, { "id": "R-BTA-73762", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "resource": "Reactome", "description": "RNA Polymerase I Transcription Initiation" }, { "id": "R-BTA-73772", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "resource": "Reactome", "description": "RNA Polymerase I Promoter Escape" }, { "id": "R-BTA-73863", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73863", "resource": "Reactome", "description": "RNA Polymerase I Transcription Termination" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XUW2-1", "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "TAF1D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTDTDEAHASGSDYPHAQDLISTRRKKRSKIPECAANAQKEPLCSRQEDATPEESSDELSSTYTSSAEVDSSDSEIDVPAASGSKHHRKCSDAPSKQKRRSQPSRPQAEADAGVPDSESSDSSLPPQSPVRPFEASQEKKSKLNLKAIFAYHFRGRKFKAAAHRKYRSSGSQKTKKPSEHSRRRGGKQPMTASPQERRKRLKDRGFQFPFVEKHYGRKHIPLNMVLSYEQAAAKGYFQYVEMLKYEEHLKKALKALEASEDLERECLAVRKHKYLDDEGPISPIQETNDDDDGDNNCLGSDNPEDFDVRVVDNSSFIISSKIPNKRKSKARTKRVKSAGVVEVKKSAADK", "length": 350 }, "evidence": [ { "id": "Q32LB6", "url": "https://omabrowser.org/oma/group/Q32LB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HSP8-1", "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "Taf1d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQSEVTSVDCMTPDRAADIGHQSDDSSDSLFKTQYVLSPTRKQRNPTTKRVTLPANVDTDTSSDSSIEPRLLTLKAIFERFKKKKRKKRKYKPKLRPRGRPPGIKNARNPRRSQIGVKQIKNKGAVFPFLESENGRKPLPWKKILTYEQAVARGFFHHIEKLKYEHHLKECLKQMHAGEDLEKEDFESRRHKYIDDEGGPLSPIEEPLTEDEATNPESECDIKLVEDTCFIISSEFSKRNLEQGTSKKDSAFSKKAKAKDNAHREHGTQRAWNGRAWKGDLHVNIKEGLS", "length": 291 }, "evidence": [ { "id": "Q32LB6", "url": "https://omabrowser.org/oma/group/Q32LB6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5M948-1", "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "Taf1d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQSEVDSVDCVTSDRDGDIGNQSDDSSNSSLFKTQCVPSPTRKQRIPTVKCVPSLASVETDSSSDSSLEPRPLTLKAIFERFKKKKRKKRKKRKYKPKLRRQGRPSGTRNIRRSQIDAKQIKDKGAVFPFLESESGRKTLPWKKILTYEQAVARGFFHHIEKLKYEHHLKECLSQMHAGEDLEKEDFDSRRHKYMDDDGPLSPIEEPSTEDEATDPQSECDIKLVEDSCFIISTEFPRKRNLEQGKIKKESAFSKKSKAKDATQRGNRRSWKGGEHACLHSEVS", "length": 285 }, "evidence": [ { "id": "Q32LB6", "url": "https://omabrowser.org/oma/group/Q32LB6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H5J8-1", "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "TAF1D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDKSGIDSLDHVTSDAVELANRSDNSSDSSLFKTQCIPYSPKGEKRNPIRKFVRTPESVHASDSSSDSSFEPIPLTIKAIFERFKNRKKRYKKKKKRRYQPTGRPRGRPEGRRNPIYSLIDKKKQFRSRGSGFPFLESENEKNAPWRKILTFEQAVARGFFNYIEKLKYEHHLKESLKQMNVGEDLENEDFDSRRYKFLDDDGSISPIEESTAEDEDATHLEDNECDIKLAGDSFIVSSEFPVRLSVYLEEEDITEEAALSKKRATKAKNTGQRGLKM", "length": 278 }, "evidence": [ { "id": "Q32LB6", "url": "https://omabrowser.org/oma/group/Q32LB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "RNA polymerase transcription factor SL1 complex", "id": "GO:0005668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005668", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q32LB6", "url": "https://www.uniprot.org/uniprotkb/Q32LB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 274, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 20, 132, 229 ], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB7-1", "uniprot_ac": "Q32LB7", "uniprot_id": "VATE2_BOVIN", "mass": { "chemical_mass": 26171.0, "monoisotopic_mass": 26171.0 }, "refseq": { "ac": "NP_001073081", "name": "V-type proton ATPase subunit E 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" }, "gene_names": [ { "name": "ATP6V1E2", "type": "recommended", "evidence": [ { "id": "Q32LB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB7" } ] }, { "name": "ATP6V1E2", "type": "synonym", "evidence": [ { "id": "NP_001073081", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" } ] } ], "protein_names": [ { "name": "V-type proton ATPase subunit E 2", "type": "recommended", "evidence": [ { "id": "Q32LB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB7/entry#names_and_taxonomy" } ] }, { "name": "ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2", "type": "synonym", "evidence": [ { "id": "NP_001073081", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" } ] }, { "name": "V-ATPase subunit E 2", "type": "synonym", "evidence": [ { "id": "NP_001073081", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" }, { "id": "Q32LB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB7/entry#names_and_taxonomy" } ] }, { "name": "V-type proton ATPase subunit E 2", "type": "synonym", "evidence": [ { "id": "NP_001073081", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" } ] }, { "name": "Vacuolar proton pump subunit E 2", "type": "synonym", "evidence": [ { "id": "Q32LB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB7/entry#names_and_taxonomy" } ] }, { "name": "vacuolar proton pump subunit E 2", "type": "synonym", "evidence": [ { "id": "NP_001073081", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081" } ] } ], "function": [ { "annotation": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.", "evidence": [ { "database": "UniProtKB", "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7#function" }, { "database": "UniProtKB", "id": "P11019", "url": "https://www.uniprot.org/uniprotkb/P11019#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATP6V1E2", "url": "https://www.uniprot.org/uniprotkb/Q32LB7", "locus": { "chromosome": "11", "start_pos": 28965693, "end_pos": 28991336, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013734", "url": "https://www.ensembl.org/id/ENSBTAG00000013734" } ] } } ], "crossref": [ { "id": "Q32LB7", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540113", "url": "https://www.ncbi.nlm.nih.gov/gene/540113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1871361", "url": "https://www.iedb.org/epitope/1871361", "database": "IEDB", "categories": [ "Other" ] }, { "id": "530711", "url": "https://www.iedb.org/epitope/530711", "database": "IEDB", "categories": [ "Other" ] }, { "id": "531459", "url": "https://www.iedb.org/epitope/531459", "database": "IEDB", "categories": [ "Other" ] }, { "id": "531460", "url": "https://www.iedb.org/epitope/531460", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR002842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540113", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540113", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRPQDHL", "url": "https://omabrowser.org/oma/group/CRPQDHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LB7", "url": "https://www.orthodb.org/?gene=Q32LB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45715", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45715", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01991", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01991", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q32LB7", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q32LB7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-BTA-1222556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1222556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77387", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77387", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-917977", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917977", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983712", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983712", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001073081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073081", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSDVDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSTLRNQARLKVLRARNDLISELLNDAKLRLSRIVTDPEFYQGLLDKLVLQGLLRLLEPVVIVRCRPQDHFLVEAAVQRAIPQYTAVSHRCVEVQVDKEVQLATDTTGGVEVYSSDQRIMVSNTLESRLDLLSQQKMPEIRKALFGANANRKFFV", "length": 226, "header": "sp|Q32LB7-1|VATE2_BOVIN Isoform 1 of V-type proton ATPase subunit E 2 OS=Bos taurus OX=9913 GN=ATP6V1E2 PE=2 SV=1 CANONICAL=Q32LB7-1" }, "isoforms": [ { "isoform_ac": "Q32LB7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB7/entry#Q32LB7-1", "sequence": { "sequence": "MALSDVDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSTLRNQARLKVLRARNDLISELLNDAKLRLSRIVTDPEFYQGLLDKLVLQGLLRLLEPVVIVRCRPQDHFLVEAAVQRAIPQYTAVSHRCVEVQVDKEVQLATDTTGGVEVYSSDQRIMVSNTLESRLDLLSQQKMPEIRKALFGANANRKFFV", "length": 226, "header": "sp|Q32LB7-1|VATE2_BOVIN Isoform 1 of V-type proton ATPase subunit E 2 OS=Bos taurus OX=9913 GN=ATP6V1E2 PE=2 SV=1 CANONICAL=Q32LB7-1" }, "locus": { "chromosome": "11", "start_pos": 28967024, "end_pos": 28966347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097495.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097495.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "530711", "url": "https://www.iedb.org/epitope/530711" }, { "database": "IEDB", "id": "531459", "url": "https://www.iedb.org/epitope/531459" }, { "database": "IEDB", "id": "531460", "url": "https://www.iedb.org/epitope/531460" }, { "database": "IEDB", "id": "1871361", "url": "https://www.iedb.org/epitope/1871361" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] } ], "pathway": [ { "id": "bta:540113", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540113", "resource": "KEGG Pathway" }, { "id": "R-BTA-1222556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1222556", "resource": "Reactome", "description": "ROS and RNS production in phagocytes" }, { "id": "R-BTA-77387", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77387", "resource": "Reactome", "description": "Insulin receptor recycling" }, { "id": "R-BTA-917977", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917977", "resource": "Reactome", "description": "Transferrin endocytosis and recycling" }, { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" }, { "id": "R-BTA-983712", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983712", "resource": "Reactome", "description": "Ion channel transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0U5A2-1", "protein_name": "ATPase H+ transporting V1 subunit E2", "gene_name": "ATP6V1E2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALSDVDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSTMRNQARLKVLRARNDLISELLNDAKLSLSRIVADQEVYQALLDKLVLQGLLRLLEPVVIIRCRPQDLFLVKAAVQKAIPQYTTISHKHVEVQVDQEVQLATDAAGGVEVYSGDQRIKVSNTLESRLDLLFQQKMPEIRKALFGANANRKYFV", "length": 226 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZJ78-1", "protein_name": "ATPase H+ transporting V1 subunit E2", "gene_name": "Atp6v1e2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALTDIDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMDYFEKKEKQIEQQKKIQLSTMRNQARITVLRARDNLILELLKEAKMRLSRIVSDEEFYQDLLDKLVLQALLRLLEPVMIVRCREQDFYLVQSALLRAIPQYMMLCQKHLEVQIDQTEYLSSNAAGGVEVYSSDRKIKVSNTLESRLNLAALQNMPEIRRTLFGDNSNRKFFT", "length": 226 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I8N5-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "Atp6v1e2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALTDLDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMDYYEKKEKQIEQQKKIQLSTMRNQARLTVLRARDNLILELLKEAKVRLSKIVLDLDIYQELLDKLVLQALIRLLEPVMIVRCRQQDLHLVEAAVQRAIPHYMILCQKHSEVQVDREAYLSSNAAGGVEVYSNDQRIKVSNTLESRLNLAALEKMPEIRKTLFGVNANRKFFT", "length": 226 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALSDVDVKKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEAKLRLSRIVEDPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVQIDKEAYLAVNAAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFGANTNRKFFI", "length": 226 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9C9Z8-1", "protein_name": "V-type proton ATPase subunit E2", "gene_name": "VHA-E2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNDADVSKQIQQMVRFIRQEAEEKANEISISAEEEFNIERLQLLESAKRKLRQDYDRKLKQVDIRKRIDYSTQLNASRIKYLQAQDDVVTAMKDSAAKDLLRVSNDKNNYKKLLKSLIIESLLRLKEPSVLLRCREMDKKVVESVIEDAKRQYAEKAKVGSPKITIDEKVFLPPPPNPKLPDSHDPHCSGGVVLASQDGKIVCENTLDARLDVAFRQKLPQIRTRLVGAPETSRA", "length": 235 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9D593-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "Atp6v1e2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTDIDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMDYFEKKEKQIEQQKKIQLSTMRNQARITVLRARDNLILELLKDAKMRLSRIVSDEEIYQDLLDKLVLQALLRLLEPVMIVRCRPQDLHLVESAVLRAIPQYMRLCQKHLEVQVDQTEHLPSNAAGGVEVYSSDQKIKVSNTLESRLNLAAMQKMPEIRGILFGDNTSRKFFT", "length": 226 }, "evidence": [ { "id": "Q32LB7", "url": "https://omabrowser.org/oma/group/Q32LB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "proton-transporting two-sector ATPase complex, catalytic domain", "id": "GO:0033178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033178", "evidence": [ { "database": "UniProtKB", "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proton-transporting ATPase activity, rotational mechanism", "id": "GO:0046961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046961", "evidence": [ { "database": "UniProtKB", "id": "Q32LB7", "url": "https://www.uniprot.org/uniprotkb/Q32LB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32LD1-1", "uniprot_ac": "Q32LD1", "uniprot_id": "BAP18_BOVIN", "mass": { "chemical_mass": 17960.0, "monoisotopic_mass": 17960.0 }, "refseq": { "ac": "NP_001033181", "name": "BPTF-associated chromatin complex component 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" }, "gene_names": [ { "name": "BACC1", "type": "recommended", "evidence": [ { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ] }, { "name": "C19H17orf49", "type": "recommended", "evidence": [ { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ] }, { "name": "BACC1", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] }, { "name": "BAP18", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" }, { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ] }, { "name": "C17orf49", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] }, { "name": "C19H17orf49", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] } ], "protein_names": [ { "name": "BPTF-associated chromatin complex component 1", "type": "recommended", "evidence": [ { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#names_and_taxonomy" } ] }, { "name": "BPTF-associated chromatin complex component 1", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] }, { "name": "BPTF-associated protein of 18 kDa", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" }, { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#names_and_taxonomy" } ] }, { "name": "Chromatin complex subunit BAP18", "type": "synonym", "evidence": [ { "id": "Q32LD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#names_and_taxonomy" } ] }, { "name": "MLL1/MLL complex subunit C17orf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] }, { "name": "chromatin complex subunit BAP18", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] }, { "name": "chromatin complexes subunit BAP18", "type": "synonym", "evidence": [ { "id": "NP_001033181", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181" } ] } ], "function": [ { "annotation": "Component of chromatin complexes such as the MLL1/MLL and NURF complexes.", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1#function" }, { "database": "UniProtKB", "id": "A0A3Q1N6H0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6H0#function" }, { "database": "UniProtKB", "id": "ARBA00059556", "url": "https://www.uniprot.org/uniprotkb/ARBA00059556#function" }, { "database": "UniProtKB", "id": "A0AAA9SJR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR4#function" }, { "database": "UniProtKB", "id": "A0AAA9S2F7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BACC1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1", "locus": {} } ], "crossref": [ { "id": "Q32LD1", "url": "https://alphafold.ebi.ac.uk/entry/Q32LD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021931", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021931", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512885", "url": "https://www.ncbi.nlm.nih.gov/gene/512885", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512885", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512885", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKWADED", "url": "https://omabrowser.org/oma/group/GKWADED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N6H0", "url": "https://www.orthodb.org/?gene=A0A3Q1N6H0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32LD1", "url": "https://www.orthodb.org/?gene=Q32LD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21397:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21397:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033181", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6H0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6H0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDLVDIEGLGETPPTKKLNFDQA", "length": 172, "header": "sp|Q32LD1-1|BAP18_BOVIN Isoform 1 of BPTF-associated chromatin complex component 1 OS=Bos taurus OX=9913 GN=BACC1 PE=2 SV=1 CANONICAL=Q32LD1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N6H0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#A0A3Q1N6H0-1", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDLVDIEGLGETPPTKKLNFDQGRSPLPPKTAEGMGDGGEGLSRSPLP", "length": 197, "header": "tr|A0A3Q1N6H0-1|A0A3Q1N6H0_BOVIN Computationally mapped isoform of BPTF-associated chromatin complex component 1 OS=Bos taurus OX=9913 GN=C19H17orf49 PE=4 SV=1 CANONICAL=Q32LD1-1" }, "locus": { "chromosome": "19", "start_pos": 26807028, "end_pos": 26804712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079462.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079462.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066070.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066070.1" } ] } }, { "isoform_ac": "A0AAA9S2F7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#A0AAA9S2F7-1", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADSLTLDSGLLLTSADPPLLSC", "length": 157, "header": "tr|A0AAA9S2F7-1|A0AAA9S2F7_BOVIN Computationally mapped isoform of BPTF-associated chromatin complex component 1 OS=Bos taurus OX=9913 GN=C19H17orf49 PE=4 SV=2 CANONICAL=Q32LD1-1" }, "locus": { "chromosome": "19", "start_pos": 26807219, "end_pos": 26804712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112148.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112148.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080094.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080094.2" } ] } }, { "isoform_ac": "A0AAA9SJR4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#A0AAA9SJR4-1", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDLVDIEGLGETPPTKKLNFDQDSLTLDSGLLLTSADPPLLSC", "length": 192, "header": "tr|A0AAA9SJR4-1|A0AAA9SJR4_BOVIN Computationally mapped isoform of BPTF-associated chromatin complex component 1 OS=Bos taurus OX=9913 GN=C19H17orf49 PE=4 SV=1 CANONICAL=Q32LD1-1" }, "locus": { "chromosome": "19", "start_pos": 26807219, "end_pos": 26804712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088624.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088624.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082819.1" } ] } }, { "isoform_ac": "A0AAF6ZA66-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#A0AAF6ZA66-1", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDLVDIEGLGETPPTKKLNFDQA", "length": 138, "header": "tr|A0AAF6ZA66-1|A0AAF6ZA66_BOVIN Computationally mapped isoform of Chromosome 19 C17orf49 homolog OS=Bos taurus OX=9913 GN=C19H17orf49 PE=4 SV=2 CANONICAL=Q32LD1-1" }, "locus": { "chromosome": "19", "start_pos": 26807163, "end_pos": 26804712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029238.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029238.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029238.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029238.5" } ] } }, { "isoform_ac": "Q32LD1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1/entry#Q32LD1-1", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPADSPKKGPKKVASGVLSPPPTAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDLVDIEGLGETPPTKKLNFDQA", "length": 172, "header": "sp|Q32LD1-1|BAP18_BOVIN Isoform 1 of BPTF-associated chromatin complex component 1 OS=Bos taurus OX=9913 GN=BACC1 PE=2 SV=1 CANONICAL=Q32LD1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 114, "start_aa": "Thr", "end_pos": 114, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr114", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "site_lbl": "Ser96" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512885", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512885", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8IXM2-1", "protein_name": "BPTF-associated chromatin complex component 1", "gene_name": "BACC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPAESPKKGPKKVASGVLSPPPAAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDVVDIEGLGETPPAKKLNFDQA", "length": 172 }, "evidence": [ { "id": "Q32LD1", "url": "https://omabrowser.org/oma/group/Q32LD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCT6-1", "protein_name": "BPTF-associated chromatin complex component 1", "gene_name": "Bacc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVSDSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKTTVKRKVYEDSGIPLPAESPKKGPKKMTSGVLSPPNAPPPSSSSVPEAGVPPIKKQKADVTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA", "length": 171 }, "evidence": [ { "id": "Q32LD1", "url": "https://omabrowser.org/oma/group/Q32LD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" }, { "name": "NURF complex", "id": "GO:0016589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016589", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LD1", "url": "https://www.uniprot.org/uniprotkb/Q32LD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 172, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LD1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 114 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 96 ], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LD3-1", "uniprot_ac": "Q32LD3", "uniprot_id": "LYPD4_BOVIN", "mass": { "chemical_mass": 26872.0, "monoisotopic_mass": 26872.0 }, "refseq": { "ac": "NP_001069910", "name": "ly6/PLAUR domain-containing protein 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069910" }, "gene_names": [ { "name": "LYPD4", "type": "recommended", "evidence": [ { "id": "Q32LD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD3" } ] }, { "name": "LYPD4", "type": "synonym", "evidence": [ { "id": "NP_001069910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069910" } ] } ], "protein_names": [ { "name": "Ly6/PLAUR domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q32LD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD3/entry#names_and_taxonomy" } ] }, { "name": "ly6/PLAUR domain-containing protein 4 precursor", "type": "synonym", "evidence": [ { "id": "NP_001069910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069910" } ] }, { "name": "ly6/PLAUR domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001069910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069910" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LD3", "url": "https://www.uniprot.org/uniprotkb/Q32LD3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYPD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD3", "locus": { "chromosome": "18", "start_pos": 51382927, "end_pos": 51363289, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020251", "url": "https://www.ensembl.org/id/ENSBTAG00000020251" } ] } } ], "crossref": [ { "id": "Q32LD3", "url": "https://alphafold.ebi.ac.uk/entry/Q32LD3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020251", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020251", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23621", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23621", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23635", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23635", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617066", "url": "https://www.ncbi.nlm.nih.gov/gene/617066", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617066", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617066", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKLSEGC", "url": "https://omabrowser.org/oma/group/CKLSEGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIY1", "url": "https://www.orthodb.org/?gene=A0A452DIY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32LD3", "url": "https://www.orthodb.org/?gene=Q32LD3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16529", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16529", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16529:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16529:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIY1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIY1-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD3", "url": "https://www.uniprot.org/uniprotkb/Q32LD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPQHLSPMQLLCLLGAISSLPWAEALLCYEATSSLFRAVGLHRWQWFLLRSMVCKLNEGCEETLVFIEAGTRKGILGFKGCSPASSYPPQVSYLVSPPGLSIASYSRVCRTYLCNNLTNMNAILHLKARTPKTLKSSSHSCPTCVGEHSKSCLPNFVSSESCPRDATKCYSSTVKFQAGFLNTTFLLMGCAREHTSVFAHFHHIGSIRVTEVINIVEKALFTGAGTPCRSPSWGILLGLLFAFKG", "length": 246, "header": "sp|Q32LD3-1|LYPD4_BOVIN Isoform 1 of Ly6/PLAUR domain-containing protein 4 OS=Bos taurus OX=9913 GN=LYPD4 PE=2 SV=1 CANONICAL=Q32LD3-1" }, "isoforms": [ { "isoform_ac": "A0A452DIY1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD3/entry#A0A452DIY1-1", "sequence": { "sequence": "MGPQHLSPMQLLCLLGAISSLPWAEALLCYEATSSLFRAVGLHRWQWFLLRSMVCKLNEGCEETLVFIEAGTRKGILGFKGCSPASSYPPQVSYLVSPPGLSIASYSRVCRTYLCNNLTNMNAILHLKARTPKTLKSSSHSCPTCVGEHSKSCLPNFVSSESCPRDATKCYSSTVKVQAGFLNTTFLLMGCAREHTSVFAHFHHIGSIRVTEVINIVEKALFTGAGTPCRSPSWGILLGLLFAFKG", "length": 246, "header": "tr|A0A452DIY1-1|A0A452DIY1_BOVIN Computationally mapped isoform of LY6/PLAUR domain containing 4 OS=Bos taurus OX=9913 GN=LYPD4 PE=4 SV=1 CANONICAL=Q32LD3-1" }, "locus": { "chromosome": "18", "start_pos": 51382859, "end_pos": 51381221, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026978.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026978.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026978.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026978.4" } ] } }, { "isoform_ac": "A0AAA9TUM0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD3/entry#A0AAA9TUM0-1", "sequence": { "sequence": "MSHLFCWSWLLGLLQISGLRILCVRYSGQKSVAEVTSIWTAVQGSSTRQNWKGAEALLCYEATSSLFRAVGLHRWQWFLLRSMVCKLNEGCEETLVFIEAGTRKGILGFKGCSPASSYPPQVSYLVSPPGLSIASYSRVCRTYLCNNLTNMNAILHLKARTPKTLKSSSHSCPTCVGEHSKSCLPNFVSSESCPRDATKCYSSTVKVQAGFLNTTFLLMGCAREHTSVFAHFHHIGSIRVTEVINIVEKALFTGAGTPCRSPSWGILLGLLFAFKG", "length": 276, "header": "tr|A0AAA9TUM0-1|A0AAA9TUM0_BOVIN Computationally mapped isoform of LY6/PLAUR domain containing 4 OS=Bos taurus OX=9913 GN=LYPD4 PE=4 SV=1 CANONICAL=Q32LD3-1" }, "locus": { "chromosome": "18", "start_pos": 51382859, "end_pos": 51374273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089593.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089593.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100822.1" } ] } }, { "isoform_ac": "A0AAA9U1D4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD3/entry#A0AAA9U1D4-1", "sequence": { "sequence": "MCVCLVTQSCQTLCDPMHCIPPGSSAHGDSPAKNRGVGCHALLQGIFPTQGSNPGLLQCRQILYLGSPSSDKVHTILILSANVFCVPTLCKKQSSPIFCSAGTRKGILGFKGCSPASSYPPQVSYLVSPPGLSIASYSRVCRTYLCNNLTNMNAILHLKARTPKTLKSSSHSCPTCVGEHSKSCLPNFVSSESCPRDATKCYSSTVKVQAGFLNTTFLLMGCAREHTSVFAHFHHIGSIRVTEVINIVEKALFTGAGTPCRSPSWGILLGLLFAFKG", "length": 277, "header": "tr|A0AAA9U1D4-1|A0AAA9U1D4_BOVIN Computationally mapped isoform of LY6/PLAUR domain containing 4 OS=Bos taurus OX=9913 GN=LYPD4 PE=4 SV=1 CANONICAL=Q32LD3-1" }, "locus": { "chromosome": "18", "start_pos": 51382859, "end_pos": 51363394, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092903.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092903.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103007.1" } ] } }, { "isoform_ac": "Q32LD3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD3/entry#Q32LD3-1", "sequence": { "sequence": "MGPQHLSPMQLLCLLGAISSLPWAEALLCYEATSSLFRAVGLHRWQWFLLRSMVCKLNEGCEETLVFIEAGTRKGILGFKGCSPASSYPPQVSYLVSPPGLSIASYSRVCRTYLCNNLTNMNAILHLKARTPKTLKSSSHSCPTCVGEHSKSCLPNFVSSESCPRDATKCYSSTVKFQAGFLNTTFLLMGCAREHTSVFAHFHHIGSIRVTEVINIVEKALFTGAGTPCRSPSWGILLGLLFAFKG", "length": 246, "header": "sp|Q32LD3-1|LYPD4_BOVIN Isoform 1 of Ly6/PLAUR domain-containing protein 4 OS=Bos taurus OX=9913 GN=LYPD4 PE=2 SV=1 CANONICAL=Q32LD3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 117, "start_aa": "Asn", "end_pos": 117, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn117", "evidence": [ { "id": "Q32LD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617066", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617066", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZHB4-1", "protein_name": "Ly6/Plaur domain containing 4", "gene_name": "Lypd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLKDWRSLQLLCLLEAISLLPCAEALLCYEATASAFRAVSLHNWKWLLLRSMVCNQREGCEETIVFIETGTRKGILSFKGCSSAFSYPPQITYLVSPPGVSIASYSRVCRSYLCNNLTNLEPFVRLKASQPISTLPSGKSCPTCVGKHDEECLPSFVTTENCPFSASTCHSSTLQFQAGNLNTTFLIMGCARESRKLLSDFQHIGSIRVTEVINILDKSSAVGAGHCSRGPSWSALLCLLRLFRH", "length": 246 }, "evidence": [ { "id": "Q32LD3", "url": "https://omabrowser.org/oma/group/Q32LD3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UWN0-1", "protein_name": "Ly6/PLAUR domain-containing protein 4", "gene_name": "LYPD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPQHLRLVQLFCLLGAISTLPRAGALLCYEATASRFRAVAFHNWKWLLMRNMVCKLQEGCEETLVFIETGTARGVVGFKGCSSSSSYPAQISYLVSPPGVSIASYSRVCRSYLCNNLTNLEPFVKLKASTPKSITSASCSCPTCVGEHMKDCLPNFVTTNSCPLAASTCYSSTLKFQAGFLNTTFLLMGCAREHNQLLADFHHIGSIKVTEVLNILEKSQIVGAASSRQDPAWGVVLGLLFAFRD", "length": 246 }, "evidence": [ { "id": "Q32LD3", "url": "https://omabrowser.org/oma/group/Q32LD3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BVP6-1", "protein_name": "Ly6/PLAUR domain-containing protein 4", "gene_name": "Lypd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILQAWRSLQLLYLLEAISLLPCTEALLCYEATASAFRAVSLHNWKWLLLRSMVCNQREGCEETVVFIETGTSKGVLSFKGCSSAFSYPPQISYLVSPPGVSIASYSRVCRSYLCNNLTNLEPFVRLKASQPMSTLPSAKSCPSCVGKHDQECLPSFVTTENCPFAASSCYSSTLKFQAGNLNTTFLIMGCARDSHKLLADFQHIGSIRVTEVINVLDKSEAVSAGHCSQGISWSVLLCLLILLRD", "length": 246 }, "evidence": [ { "id": "Q32LD3", "url": "https://omabrowser.org/oma/group/Q32LD3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane raft", "id": "GO:0044853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044853", "evidence": [ { "database": "UniProtKB", "id": "Q32LD3", "url": "https://www.uniprot.org/uniprotkb/Q32LD3" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "Q32LD3", "url": "https://www.uniprot.org/uniprotkb/Q32LD3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32LD3", "url": "https://www.uniprot.org/uniprotkb/Q32LD3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LD3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LD3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LD3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 117 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 183, "end_pos": 185 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LE6-1", "uniprot_ac": "Q32LE6", "uniprot_id": "DMRTD_BOVIN", "mass": { "chemical_mass": 39352.0, "monoisotopic_mass": 39352.0 }, "refseq": { "ac": "NP_001033271", "name": "doublesex- and mab-3-related transcription factor C2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033271" }, "gene_names": [ { "name": "DMRTC2", "type": "recommended", "evidence": [ { "id": "Q32LE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ] }, { "name": "DMRTC2", "type": "synonym", "evidence": [ { "id": "NP_001033271", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033271" } ] }, { "name": "Dmrt7", "type": "synonym", "evidence": [ { "id": "NP_001033271", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033271" } ] } ], "protein_names": [ { "name": "Doublesex- and mab-3-related transcription factor C2", "type": "recommended", "evidence": [ { "id": "Q32LE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE6/entry#names_and_taxonomy" } ] }, { "name": "doublesex- and mab-3-related transcription factor C2", "type": "synonym", "evidence": [ { "id": "NP_001033271", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033271" } ] } ], "function": [ { "annotation": "May be involved in sexual development.", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DMRTC2", "url": "https://www.uniprot.org/uniprotkb/Q32LE6", "locus": { "chromosome": "18", "start_pos": 51367681, "end_pos": 51373336, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019273", "url": "https://www.ensembl.org/id/ENSBTAG00000019273" } ] } } ], "crossref": [ { "id": "Q32LE6", "url": "https://alphafold.ebi.ac.uk/entry/Q32LE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "539134", "url": "https://www.ncbi.nlm.nih.gov/gene/539134", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539134", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539134", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LE6", "url": "https://www.orthodb.org/?gene=Q32LE6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12322:SF124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12322:SF124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00751", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033271", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LE6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVRRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 370, "header": "sp|Q32LE6-1|DMRTD_BOVIN Isoform 1 of Doublesex- and mab-3-related transcription factor C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=2 SV=1 CANONICAL=Q32LE6-1" }, "isoforms": [ { "isoform_ac": "Q32LE6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE6/entry#Q32LE6-1", "sequence": { "sequence": "MDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVRRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 370, "header": "sp|Q32LE6-1|DMRTD_BOVIN Isoform 1 of Doublesex- and mab-3-related transcription factor C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=2 SV=1 CANONICAL=Q32LE6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539134", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539134", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" }, { "name": "adult locomotory behavior", "id": "GO:0008344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008344", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" }, { "name": "sex differentiation", "id": "GO:0007548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007548", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q32LE6", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LE6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LE6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LE6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE6" }, { "id": "PRU00070", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00070" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "DM", "eco_id": "ECO_0000255", "start_pos": 42, "end_pos": 89, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LH3-1", "uniprot_ac": "Q32LH3", "uniprot_id": "PIHD2_BOVIN", "mass": { "chemical_mass": 35988.0, "monoisotopic_mass": 35988.0 }, "refseq": { "ac": "NP_001033278", "name": "PIH1 domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033278" }, "gene_names": [ { "name": "PIH1D2", "type": "recommended", "evidence": [ { "id": "Q32LH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ] }, { "name": "PIH1D2", "type": "synonym", "evidence": [ { "id": "NP_001033278", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033278" } ] } ], "protein_names": [ { "name": "PIH1 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q32LH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH3/entry#names_and_taxonomy" } ] }, { "name": "PIH1 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001033278", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033278" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIH1D2", "url": "https://www.uniprot.org/uniprotkb/Q32LH3", "locus": { "chromosome": "15", "start_pos": 22370256, "end_pos": 22382689, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005156", "url": "https://www.ensembl.org/id/ENSBTAG00000005156" } ] } } ], "crossref": [ { "id": "Q32LH3", "url": "https://alphafold.ebi.ac.uk/entry/Q32LH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06464", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06464", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539917", "url": "https://www.ncbi.nlm.nih.gov/gene/539917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539917", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539917", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LH3", "url": "https://www.orthodb.org/?gene=Q32LH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033278", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LH3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSSKGLLTQVTQFWNLLDDLAESNPESYQKFIQQQLKEGKELCAAPEPQLCLQTRILKPKEKLLFINLCQWKRIPAPESATHPVPLSIGRPEDISETSDVYTVIDVAYHPDVLQAAEKDQVKKDQLIRMAMRCIEEQFQFTLSNCYYVTKFRIKGSIQRMKQNLMGIQTNPADLREKMRNELTLEKIRSSTVSNSDQFPQLLLPEDQVSSKTACLIEEISSTEIKVEMKRPAYELKIVADQNEKPLKIELKVELPGVNSVSLCDLSVSEDDILIEVSEKYRLYLNLPESVDTEMTTAKFIKEKATLIVTMPLV", "length": 315, "header": "sp|Q32LH3-1|PIHD2_BOVIN Isoform 1 of PIH1 domain-containing protein 2 OS=Bos taurus OX=9913 GN=PIH1D2 PE=2 SV=1 CANONICAL=Q32LH3-1" }, "isoforms": [ { "isoform_ac": "Q32LH3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH3/entry#Q32LH3-1", "sequence": { "sequence": "MESSSKGLLTQVTQFWNLLDDLAESNPESYQKFIQQQLKEGKELCAAPEPQLCLQTRILKPKEKLLFINLCQWKRIPAPESATHPVPLSIGRPEDISETSDVYTVIDVAYHPDVLQAAEKDQVKKDQLIRMAMRCIEEQFQFTLSNCYYVTKFRIKGSIQRMKQNLMGIQTNPADLREKMRNELTLEKIRSSTVSNSDQFPQLLLPEDQVSSKTACLIEEISSTEIKVEMKRPAYELKIVADQNEKPLKIELKVELPGVNSVSLCDLSVSEDDILIEVSEKYRLYLNLPESVDTEMTTAKFIKEKATLIVTMPLV", "length": 315, "header": "sp|Q32LH3-1|PIHD2_BOVIN Isoform 1 of PIH1 domain-containing protein 2 OS=Bos taurus OX=9913 GN=PIH1D2 PE=2 SV=1 CANONICAL=Q32LH3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539917", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "R2TP complex", "id": "GO:0097255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097255", "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "pmid": "" }, { "name": "box C/D snoRNP assembly", "id": "GO:0000492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000492", "evidence": [ { "database": "UniProtKB", "id": "Q32LH3", "url": "https://www.uniprot.org/uniprotkb/Q32LH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 315, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LH3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LH4-1", "uniprot_ac": "Q32LH4", "uniprot_id": "NIT1_BOVIN", "mass": { "chemical_mass": 36240.0, "monoisotopic_mass": 36240.0 }, "refseq": { "ac": "NP_001033112", "name": "deaminated glutathione amidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112" }, "gene_names": [ { "name": "NIT1", "type": "recommended", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ] }, { "name": "NIT1", "type": "synonym", "evidence": [ { "id": "NP_001033112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112" } ] } ], "protein_names": [ { "name": "Deaminated glutathione amidase", "type": "recommended", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.128", "type": "synonym", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4/entry#names_and_taxonomy" } ] }, { "name": "Nitrilase homolog 1", "type": "synonym", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4/entry#names_and_taxonomy" } ] }, { "name": "dGSH amidase", "type": "synonym", "evidence": [ { "id": "NP_001033112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112" }, { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4/entry#names_and_taxonomy" } ] }, { "name": "deaminated glutathione amidase", "type": "synonym", "evidence": [ { "id": "NP_001033112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112" } ] }, { "name": "nitrilase homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001033112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells. It is also a negative regulator of primary T-cells.", "evidence": [ { "database": "UniProtKB", "id": "Q32LH4", "url": "https://www.uniprot.org/uniprotkb/Q32LH4#function" }, { "database": "UniProtKB", "id": "Q8VDK1", "url": "https://www.uniprot.org/uniprotkb/Q8VDK1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LH4", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIT1", "url": "https://www.uniprot.org/uniprotkb/Q32LH4", "locus": { "chromosome": "3", "start_pos": 8370922, "end_pos": 8377185, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020153", "url": "https://www.ensembl.org/id/ENSBTAG00000020153" } ] } } ], "crossref": [ { "id": "Q32LH4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504199", "url": "https://www.ncbi.nlm.nih.gov/gene/504199", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504199", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504199", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LH4", "url": "https://www.orthodb.org/?gene=Q32LH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23088", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23088", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23088:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23088:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00795", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00795", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033112", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54532", "url": "https://www.rhea-db.org/rhea/54532", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LH4", "url": "https://www.uniprot.org/uniprotkb/Q32LH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LH4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGFIIRPPHQLLSLLSCPGLRIPRFSVLCAPPRLRTMAASSSFSELPLVAVCQVTSTPDKEQNFKTCAELIREAARLGACLAFLPEAFDFIARDPEETRRLSEPLSGNLLEEYTQLARECGLWLSLGGFHERGQDWEQTQKIYNCHVIMNNMGSVVATYRKTHLCDVEIPGQGPMRESNSTIPGPSLESPISTPAGKIGLAICYDMRFPELSLALVQAGAEILTYPSAFGSVTGPAHWEVLLRARAIETQCYVVAAAQCGRHHEKRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLNYLQQLRKQLPVFQHRRPDLYGNLGHPLS", "length": 328, "header": "sp|Q32LH4-1|NIT1_BOVIN Isoform 1 of Deaminated glutathione amidase OS=Bos taurus OX=9913 GN=NIT1 PE=2 SV=1 CANONICAL=Q32LH4-1" }, "isoforms": [ { "isoform_ac": "Q32LH4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LH4/entry#Q32LH4-1", "sequence": { "sequence": "MLGFIIRPPHQLLSLLSCPGLRIPRFSVLCAPPRLRTMAASSSFSELPLVAVCQVTSTPDKEQNFKTCAELIREAARLGACLAFLPEAFDFIARDPEETRRLSEPLSGNLLEEYTQLARECGLWLSLGGFHERGQDWEQTQKIYNCHVIMNNMGSVVATYRKTHLCDVEIPGQGPMRESNSTIPGPSLESPISTPAGKIGLAICYDMRFPELSLALVQAGAEILTYPSAFGSVTGPAHWEVLLRARAIETQCYVVAAAQCGRHHEKRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLNYLQQLRKQLPVFQHRRPDLYGNLGHPLS", "length": 328, "header": "sp|Q32LH4-1|NIT1_BOVIN Isoform 1 of Deaminated glutathione amidase OS=Bos taurus OX=9913 GN=NIT1 PE=2 SV=1 CANONICAL=Q32LH4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:504199", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504199", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32LH4", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "deaminated glutathione amidase activity", "id": "GO:0110050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110050", "evidence": [ { "database": "UniProtKB", "id": "Q32LH4", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54532", "name": "", "equation": "N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LH4-1" ], "evidence": [ { "id": "54532", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54532" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q32LH4", "gene_name": "NIT1", "activity": [ { "ec_number": "3.5.1.128", "activity": "N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate.", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ] }, { "ec_number": "3.5.1.128", "activity": "", "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 328, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LH4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH4" }, { "id": "PRU00054", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CN hydrolase", "eco_id": "ECO_0000255", "start_pos": 47, "end_pos": 299, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.1.128", "ec_name": "N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate.", "evidence": [ { "id": "3.5.1.128", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.128" }, { "id": "3.5.1.128", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.128" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LJ5-1", "uniprot_ac": "Q32LJ5", "uniprot_id": "SPEM1_BOVIN", "mass": { "chemical_mass": 35332.0, "monoisotopic_mass": 35332.0 }, "refseq": { "ac": "NP_001073054", "name": "spermatid maturation protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073054" }, "gene_names": [ { "name": "SPEM1", "type": "recommended", "evidence": [ { "id": "Q32LJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ] }, { "name": "SPEM1", "type": "synonym", "evidence": [ { "id": "NP_001073054", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073054" } ] } ], "protein_names": [ { "name": "Spermatid maturation protein 1", "type": "recommended", "evidence": [ { "id": "Q32LJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5/entry#names_and_taxonomy" } ] }, { "name": "spermatid maturation protein 1", "type": "synonym", "evidence": [ { "id": "NP_001073054", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073054" } ] } ], "function": [ { "annotation": "Required for proper cytoplasm removal during spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPEM1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5", "locus": { "chromosome": "19", "start_pos": 27100767, "end_pos": 27099426, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020253", "url": "https://www.ensembl.org/id/ENSBTAG00000020253" } ] } } ], "crossref": [ { "id": "Q32LJ5", "url": "https://alphafold.ebi.ac.uk/entry/Q32LJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "511321", "url": "https://www.ncbi.nlm.nih.gov/gene/511321", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511321", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511321", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LJ5", "url": "https://www.orthodb.org/?gene=Q32LJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34834", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34834", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34834:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34834:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073054", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMAERPRPGWASYHNPNTNSCQDLGNSILLLLGLIICINIGINMVTLLWRRLRGFLHQVFRVICEKEASKLRSPGKQTQPSKHSSPAVHLRCTMDAVKMTVTPPPTRRRHRRGSSSRRARRPVAWAPDTDDDDDEKPPHQHTAACSHNWDYPEDWEGLQTAQRFWTPWAQDTLEPPTQTIRFQQTIEGRPLKREMQSDLGLEAYVYPVNPPLPSPQILSHKNSGGGAGAGAQAEQEQCAPAEPPILGPANVPDIPRRRSSGRVTYDARDVRRRLRELTREVEALSHCYPLASGSSTAEGTRKDWVYRSMTER", "length": 313, "header": "sp|Q32LJ5-1|SPEM1_BOVIN Isoform 1 of Spermatid maturation protein 1 OS=Bos taurus OX=9913 GN=SPEM1 PE=2 SV=2 CANONICAL=Q32LJ5-1" }, "isoforms": [ { "isoform_ac": "Q32LJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5/entry#Q32LJ5-1", "sequence": { "sequence": "MAMAERPRPGWASYHNPNTNSCQDLGNSILLLLGLIICINIGINMVTLLWRRLRGFLHQVFRVICEKEASKLRSPGKQTQPSKHSSPAVHLRCTMDAVKMTVTPPPTRRRHRRGSSSRRARRPVAWAPDTDDDDDEKPPHQHTAACSHNWDYPEDWEGLQTAQRFWTPWAQDTLEPPTQTIRFQQTIEGRPLKREMQSDLGLEAYVYPVNPPLPSPQILSHKNSGGGAGAGAQAEQEQCAPAEPPILGPANVPDIPRRRSSGRVTYDARDVRRRLRELTREVEALSHCYPLASGSSTAEGTRKDWVYRSMTER", "length": 313, "header": "sp|Q32LJ5-1|SPEM1_BOVIN Isoform 1 of Spermatid maturation protein 1 OS=Bos taurus OX=9913 GN=SPEM1 PE=2 SV=2 CANONICAL=Q32LJ5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511321", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511321", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ], "pmid": "" }, { "name": "sperm individualization", "id": "GO:0007291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007291", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ5", "url": "https://www.uniprot.org/uniprotkb/Q32LJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LJ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LJ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LJ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LK2-1", "uniprot_ac": "Q32LK2", "uniprot_id": "CYTM1_BOVIN", "mass": { "chemical_mass": 11124.0, "monoisotopic_mass": 11124.0 }, "refseq": { "ac": "NP_001071632", "name": "cysteine-rich transmembrane module-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" }, "gene_names": [ { "name": "CYSTM1", "type": "recommended", "evidence": [ { "id": "Q32LK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LK2" } ] }, { "name": "C5orf32", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] }, { "name": "C7H5orf32", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] }, { "name": "CYSTM1", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] } ], "protein_names": [ { "name": "Cysteine-rich transmembrane module-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q32LK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LK2/entry#names_and_taxonomy" } ] }, { "name": "UPF0467 protein C5orf32 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] }, { "name": "cysteine-rich and transmembrane domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] }, { "name": "cysteine-rich transmembrane module-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001071632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LK2", "url": "https://www.uniprot.org/uniprotkb/Q32LK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYSTM1", "url": "https://www.uniprot.org/uniprotkb/Q32LK2", "locus": {} } ], "crossref": [ { "id": "Q32LK2", "url": "https://alphafold.ebi.ac.uk/entry/Q32LK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "777789", "url": "https://www.ncbi.nlm.nih.gov/gene/777789", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:777789", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:777789", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETCLTAC", "url": "https://omabrowser.org/oma/group/ETCLTAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47564", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47564", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47564:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47564:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001071632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071632", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LK2", "url": "https://www.uniprot.org/uniprotkb/Q32LK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LK2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQGNPPPYPGPGPTAPYPPYPSQPMGPGFYPPGPPGGPYPPPQGGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDDLGTSTCLTACWTALCCCCLWDMLT", "length": 103, "header": "sp|Q32LK2-1|CYTM1_BOVIN Isoform 1 of Cysteine-rich transmembrane module-containing protein 1 OS=Bos taurus OX=9913 GN=CYSTM1 PE=3 SV=1 CANONICAL=Q32LK2-1" }, "isoforms": [ { "isoform_ac": "Q32LK2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LK2/entry#Q32LK2-1", "sequence": { "sequence": "MNQGNPPPYPGPGPTAPYPPYPSQPMGPGFYPPGPPGGPYPPPQGGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDDLGTSTCLTACWTALCCCCLWDMLT", "length": 103, "header": "sp|Q32LK2-1|CYTM1_BOVIN Isoform 1 of Cysteine-rich transmembrane module-containing protein 1 OS=Bos taurus OX=9913 GN=CYSTM1 PE=3 SV=1 CANONICAL=Q32LK2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 15, "start_aa": "Thr", "end_pos": 15, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr15", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:777789", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:777789", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LGP8-1", "protein_name": "Cysteine-rich transmembrane module-containing protein 1", "gene_name": "Cystm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTQGGNRREAERRFLCRVSPGSRCIARFLMNPENPPPYPGPGPTAPYPPYPQQPMGPMGAPPPQGYPYPPPQGYPYQGYPQYGWQGGPQEPPKTTDVGGPPRRNGKRKCLQKICMSLVLVDGASRLFLIVYP", "length": 133 }, "evidence": [ { "id": "Q32LK2", "url": "https://omabrowser.org/oma/group/Q32LK2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K353-1", "protein_name": "Cysteine-rich transmembrane module-containing protein 1", "gene_name": "Cystm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNPENPPPYPGPGPTAPYPPYPQQPMGPMGPMGAPPPQGYPYPPPQGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDDLGPSTCLTACWTALCCCCLWDMLT", "length": 104 }, "evidence": [ { "id": "Q32LK2", "url": "https://omabrowser.org/oma/group/Q32LK2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8S8M0-1", "protein_name": "Cysteine-rich and transmembrane domain-containing protein WIH2", "gene_name": "WIH2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSQYNQPPVGVPPPQGYPPEGYPKDAYPPQGYPPQGYPQQGYPPQGYPQQGYPQQGYPPPYAPQYPPPPQHQQQQSSPGFLEGCLAALCCCCLLDACF", "length": 98 }, "evidence": [ { "id": "Q32LK2", "url": "https://omabrowser.org/oma/group/Q32LK2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9H1C7-1", "protein_name": "Cysteine-rich transmembrane module-containing protein 1", "gene_name": "CYSTM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNQENPPPYPGPGPTAPYPPYPPQPMGPGPMGGPYPPPQGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDELGPSTCLTACWTALCCCCLWDMLT", "length": 97 }, "evidence": [ { "id": "Q32LK2", "url": "https://omabrowser.org/oma/group/Q32LK2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32LK2", "url": "https://www.uniprot.org/uniprotkb/Q32LK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 103, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LK2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 15 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LL9-1", "uniprot_ac": "Q32LL9", "uniprot_id": "CENPN_BOVIN", "mass": { "chemical_mass": 39411.0, "monoisotopic_mass": 39411.0 }, "refseq": { "ac": "NP_001033188", "name": "centromere protein N", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033188" }, "gene_names": [ { "name": "CENPN", "type": "recommended", "evidence": [ { "id": "Q32LL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ] }, { "name": "CENP-N", "type": "synonym", "evidence": [ { "id": "NP_001033188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033188" } ] }, { "name": "CENPN", "type": "synonym", "evidence": [ { "id": "NP_001033188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033188" } ] } ], "protein_names": [ { "name": "Centromere protein N", "type": "recommended", "evidence": [ { "id": "Q32LL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL9/entry#names_and_taxonomy" } ] }, { "name": "CENP-N", "type": "synonym", "evidence": [ { "id": "Q32LL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL9/entry#names_and_taxonomy" } ] }, { "name": "centromere protein N", "type": "synonym", "evidence": [ { "id": "NP_001033188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033188" } ] } ], "function": [ { "annotation": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9#function" }, { "database": "UniProtKB", "id": "Q96H22", "url": "https://www.uniprot.org/uniprotkb/Q96H22#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPN", "url": "https://www.uniprot.org/uniprotkb/Q32LL9", "locus": { "chromosome": "18", "start_pos": 7719809, "end_pos": 7700533, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011635", "url": "https://www.ensembl.org/id/ENSBTAG00000011635" } ] } } ], "crossref": [ { "id": "Q32LL9", "url": "https://alphafold.ebi.ac.uk/entry/Q32LL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "513551", "url": "https://www.ncbi.nlm.nih.gov/gene/513551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513551", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LL9", "url": "https://www.orthodb.org/?gene=Q32LL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46790", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46790", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46790:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46790:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LL9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDETLAEFFRRTILKIPMTEMMTILKTWNFMSENQLQTVNFRQRKESIVQDLVLLCEENHASLNDAAHLDIIYTQFHRHQKIWDVFQMSKAPGDDIDLFDMEQFKSSFKKILQRALKNVTVSFRDAEENSVWIRIAWGTQYKKPNQYKPAYVVYYSQTPYAFTSSSRLKSNLPLLGQALTVASKHHQIVKMDLRSRYLDSLKAIVFKQYNQSFETHNCTTSLQEGSLGLDINMDSRIIHENKVEKERVQRVTQEIFGDYPQPRLEFAQYKLETKFKSDLNGGILAEREEPLRCLVKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPNKGKNYFKIRDK", "length": 339, "header": "sp|Q32LL9-1|CENPN_BOVIN Isoform 1 of Centromere protein N OS=Bos taurus OX=9913 GN=CENPN PE=2 SV=1 CANONICAL=Q32LL9-1" }, "isoforms": [ { "isoform_ac": "Q32LL9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LL9/entry#Q32LL9-1", "sequence": { "sequence": "MDETLAEFFRRTILKIPMTEMMTILKTWNFMSENQLQTVNFRQRKESIVQDLVLLCEENHASLNDAAHLDIIYTQFHRHQKIWDVFQMSKAPGDDIDLFDMEQFKSSFKKILQRALKNVTVSFRDAEENSVWIRIAWGTQYKKPNQYKPAYVVYYSQTPYAFTSSSRLKSNLPLLGQALTVASKHHQIVKMDLRSRYLDSLKAIVFKQYNQSFETHNCTTSLQEGSLGLDINMDSRIIHENKVEKERVQRVTQEIFGDYPQPRLEFAQYKLETKFKSDLNGGILAEREEPLRCLVKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPNKGKNYFKIRDK", "length": 339, "header": "sp|Q32LL9-1|CENPN_BOVIN Isoform 1 of Centromere protein N OS=Bos taurus OX=9913 GN=CENPN PE=2 SV=1 CANONICAL=Q32LL9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 226, "end_pos": 226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "site_lbl": "Ser226" }, { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "site_lbl": "Ser235" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513551", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513551", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "pmid": "" }, { "name": "CENP-A containing chromatin assembly", "id": "GO:0034080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034080", "evidence": [ { "database": "UniProtKB", "id": "Q32LL9", "url": "https://www.uniprot.org/uniprotkb/Q32LL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 339, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 226, 235 ], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 217, "end_pos": 219 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LM4-1", "uniprot_ac": "Q32LM4", "uniprot_id": "FBX39_BOVIN", "mass": { "chemical_mass": 52771.0, "monoisotopic_mass": 52771.0 }, "refseq": { "ac": "NP_001032702", "name": "F-box only protein 39", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032702" }, "gene_names": [ { "name": "FBXO39", "type": "recommended", "evidence": [ { "id": "Q32LM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LM4" } ] }, { "name": "FBXO39", "type": "synonym", "evidence": [ { "id": "NP_001032702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032702" } ] } ], "protein_names": [ { "name": "F-box only protein 39", "type": "recommended", "evidence": [ { "id": "Q32LM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LM4/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 39", "type": "synonym", "evidence": [ { "id": "NP_001032702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032702" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "Q32LM4", "url": "https://www.uniprot.org/uniprotkb/Q32LM4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LM4", "url": "https://www.uniprot.org/uniprotkb/Q32LM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO39", "url": "https://www.uniprot.org/uniprotkb/Q32LM4", "locus": { "chromosome": "19", "start_pos": 25139357, "end_pos": 25147638, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018345", "url": "https://www.ensembl.org/id/ENSBTAG00000018345" } ] } } ], "crossref": [ { "id": "Q32LM4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018345", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018345", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539103", "url": "https://www.ncbi.nlm.nih.gov/gene/539103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MATFHNL", "url": "https://omabrowser.org/oma/group/MATFHNL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LM4", "url": "https://www.orthodb.org/?gene=Q32LM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10706:SF160", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10706:SF160", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LM4", "url": "https://www.uniprot.org/uniprotkb/Q32LM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LM4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEEDQLIQPQDQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQMMYSADLWRYRTITFSGRPSRVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLKSLSIQHLELDRLVWRNSIRSSFMKSLSFFLKKMGKHLNYLSLKGARLTTEQGCHILNALSYLRNESTVTELNIEDCFSHHLAVYSSPQFNKTMATFRNLVSLTLNYNCISDELLENLCDNNTGTLRTMNIKCHIHDPHGQVIWGMSWAKLARHATSLKVNFFFERVMKYERLARILLQEIPIRSISLRSCYFSDPDWSMRPTLTDLLPTFRHTLQKLTFEFNNNHESLDEELHLLILSCRKLFYFKIWAFLDVKFVERILKSREEGQCALRTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVIAYPMM", "length": 443, "header": "sp|Q32LM4-1|FBX39_BOVIN Isoform 1 of F-box only protein 39 OS=Bos taurus OX=9913 GN=FBXO39 PE=2 SV=1 CANONICAL=Q32LM4-1" }, "isoforms": [ { "isoform_ac": "Q32LM4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LM4/entry#Q32LM4-1", "sequence": { "sequence": "MDEEDQLIQPQDQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQMMYSADLWRYRTITFSGRPSRVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLKSLSIQHLELDRLVWRNSIRSSFMKSLSFFLKKMGKHLNYLSLKGARLTTEQGCHILNALSYLRNESTVTELNIEDCFSHHLAVYSSPQFNKTMATFRNLVSLTLNYNCISDELLENLCDNNTGTLRTMNIKCHIHDPHGQVIWGMSWAKLARHATSLKVNFFFERVMKYERLARILLQEIPIRSISLRSCYFSDPDWSMRPTLTDLLPTFRHTLQKLTFEFNNNHESLDEELHLLILSCRKLFYFKIWAFLDVKFVERILKSREEGQCALRTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVIAYPMM", "length": 443, "header": "sp|Q32LM4-1|FBX39_BOVIN Isoform 1 of F-box only protein 39 OS=Bos taurus OX=9913 GN=FBXO39 PE=2 SV=1 CANONICAL=Q32LM4-1" }, "locus": { "chromosome": "19", "start_pos": 25142922, "end_pos": 25139570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024410.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024410.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024410.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024410.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539103", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5NBU5-1", "protein_name": "F-box only protein 39", "gene_name": "Fbxo39", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEDCEVTQLQEQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFESALWYIKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQHLELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARLTVEQGCHILNSLSYMQNENMASELNIEDFFSHHLAVYGSSQFNKAMATFRNLTFLTLNYNCISDELLETLSENNAGTLRTMNIKCHVHDPHGQVVWGMSWAKLARQASNLKVNFFFERVMKYERLARILLQEIPVRSISLRSCYFSDPDWSMRPTLTDLLPTFRNTLQKLTFEFNNNHESLDEQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEEGQCSLHTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVVAYPMM", "length": 443 }, "evidence": [ { "id": "Q32LM4", "url": "https://omabrowser.org/oma/group/Q32LM4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q66H10-1", "protein_name": "F-box only protein 39", "gene_name": "Fbxo39", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDEDSEVTQPQDQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQHLELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARLTVEQGCHILNSLSYMRNENVASELNIEDFFSHHLAVYGSSQFNKAMATFHNLTFLTLNYNCISDELLETLSENNAGTLRTMNIKCHVHDPHGQVVWGMSWAKLARQASNLKVNFFFERVMKYERLARILLQEIPVRSISLRSCYFSDPDWSMRPTLTDLLPTFRNTLQKLTFEFNNNHESLDEQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEEGQCSLRTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVIAYPMM", "length": 443 }, "evidence": [ { "id": "Q32LM4", "url": "https://omabrowser.org/oma/group/Q32LM4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N4B4-1", "protein_name": "F-box only protein 39", "gene_name": "FBXO39", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESAVWYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLPTFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWAFLDVSFVERILKSQKERQCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM", "length": 442 }, "evidence": [ { "id": "Q32LM4", "url": "https://omabrowser.org/oma/group/Q32LM4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q32LM4", "url": "https://www.uniprot.org/uniprotkb/Q32LM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q32LM4", "url": "https://www.uniprot.org/uniprotkb/Q32LM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 443, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LM4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LM4" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 16, "end_pos": 61, "start_aa": "Trp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 247, "end_pos": 249 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LM5-1", "uniprot_ac": "Q32LM5", "uniprot_id": "LYRM2_BOVIN", "mass": { "chemical_mass": 10481.0, "monoisotopic_mass": 10481.0 }, "refseq": { "ac": "NP_001106781", "name": "LYR motif-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106781" }, "gene_names": [ { "name": "LYRM2", "type": "recommended", "evidence": [ { "id": "Q32LM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LM5" } ] }, { "name": "LYRM2", "type": "synonym", "evidence": [ { "id": "NP_001106781", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106781" } ] } ], "protein_names": [ { "name": "LYR motif-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q32LM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LM5/entry#names_and_taxonomy" } ] }, { "name": "LYR motif-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001106781", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106781" } ] } ], "function": [ { "annotation": "Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q32LM5", "url": "https://www.uniprot.org/uniprotkb/Q32LM5#function" }, { "database": "UniProtKB", "id": "Q9NU23", "url": "https://www.uniprot.org/uniprotkb/Q9NU23#function" }, { "database": "UniProtKB", "id": "A0AAF6ZD02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD02#function" }, { "database": "UniProtKB", "id": "ARBA00044735", "url": "https://www.uniprot.org/uniprotkb/ARBA00044735#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LM5", "url": "https://www.uniprot.org/uniprotkb/Q32LM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYRM2", "url": "https://www.uniprot.org/uniprotkb/Q32LM5", "locus": { "chromosome": "9", "start_pos": 60555713, "end_pos": 60552551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026604", "url": "https://www.ensembl.org/id/ENSBTAG00000026604" } ] } } ], "crossref": [ { "id": "Q32LM5", "url": "https://alphafold.ebi.ac.uk/entry/Q32LM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026604", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026604", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20262", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20262", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615821", "url": "https://www.ncbi.nlm.nih.gov/gene/615821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YMRDWAR", "url": "https://omabrowser.org/oma/group/YMRDWAR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LM5", "url": "https://www.orthodb.org/?gene=Q32LM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13675:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13675:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106781", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LM5", "url": "https://www.uniprot.org/uniprotkb/Q32LM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LM5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSRLPPATLTLKQFMRRQQVLLLYRRILQAIRQVPNDSDRKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALARS", "length": 88, "header": "sp|Q32LM5-1|LYRM2_BOVIN Isoform 1 of LYR motif-containing protein 2 OS=Bos taurus OX=9913 GN=LYRM2 PE=3 SV=1 CANONICAL=Q32LM5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZD02-1", "url": "https://www.uniprot.org/uniprotkb/Q32LM5/entry#A0AAF6ZD02-1", "sequence": { "sequence": "MATHPSILRGNDMSRGAWWPTAHGIEKGGRTRCRPSPRKPSSPRPVTPPPTSAPARRGFGEPRRQDDMATSRLPPATLTLKQFMRRQQVLLLYRRILQAIRQVPNDSDRKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALARS", "length": 155, "header": "tr|A0AAF6ZD02-1|A0AAF6ZD02_BOVIN Computationally mapped isoform of LYR motif-containing protein 2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q32LM5-1" }, "locus": {} }, { "isoform_ac": "Q32LM5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LM5/entry#Q32LM5-1", "sequence": { "sequence": "MATSRLPPATLTLKQFMRRQQVLLLYRRILQAIRQVPNDSDRKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALARS", "length": 88, "header": "sp|Q32LM5-1|LYRM2_BOVIN Isoform 1 of LYR motif-containing protein 2 OS=Bos taurus OX=9913 GN=LYRM2 PE=3 SV=1 CANONICAL=Q32LM5-1" }, "locus": { "chromosome": "9", "start_pos": 60555097, "end_pos": 60553690, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037876.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037876.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037698.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037698.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615821", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XK83-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "LYRM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAARCGKKDLGLLVGARLNTSQQCAHVAKKANNILACIRNGAANKSREVIVPLCTALFLRRQQVLQLYRRILRALRDVPAEADRRHLQQWAREEFRRNKDATEEDAIRMMITQGHMQLRELQKALKLAKS", "length": 131 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2GV91-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "Lyrm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASRLPPATLTLKQFMRRQQVLLLYRKILRAIKQIPSDSDRKYLQDWAREEFKRNKSATEEDTIRMMITQGNMQLKELERTLALAKS", "length": 88 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S0C3-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "LYRM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATSRLPPATLTLKQFMRRQQVLLLYRRILQAIRQVPNDSDRRYLKDWAREEFKRNKNATEEDTIRMMITQGNMQLKELEKTLALARS", "length": 88 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RIM0-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "lyrm2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVSRLPPAALSLKQFLQRQKVLCLYRDLQRTIRRVPHESDRKYLRDWARDEFRRNKSNTDQDAIRMMISQAHNHLEELRRSLALAGC", "length": 88 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6IGM9-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "CG13191", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKLPKASLSLKQFMLRQEVLKLYREIFRTIRQVPDKNSQLELKSWARHDFQTNRHQSDEVAIKMLLQHGRRSLTELRTSLQLSGVSEGK", "length": 90 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8R033-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "Lyrm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASRLPPAALTLKQFMRRQQVLLLYRKILRAIRQVPSDSDRKYLQDWAREEFKRNKSATEEDTIRMMITQGNMQLKELERTLALANS", "length": 88 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NU23-1", "protein_name": "LYR motif-containing protein 2", "gene_name": "LYRM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS", "length": 88 }, "evidence": [ { "id": "Q32LM5", "url": "https://omabrowser.org/oma/group/Q32LM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32LM5", "url": "https://www.uniprot.org/uniprotkb/Q32LM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q32LM5", "url": "https://www.uniprot.org/uniprotkb/Q32LM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 88, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LM5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LN0-1", "uniprot_ac": "Q32LN0", "uniprot_id": "EHF_BOVIN", "mass": { "chemical_mass": 35004.0, "monoisotopic_mass": 35004.0 }, "refseq": { "ac": "NP_001033125", "name": "ETS homologous factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033125" }, "gene_names": [ { "name": "EHF", "type": "recommended", "evidence": [ { "id": "Q32LN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ] }, { "name": "EHF", "type": "synonym", "evidence": [ { "id": "NP_001033125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033125" } ] } ], "protein_names": [ { "name": "ETS homologous factor", "type": "recommended", "evidence": [ { "id": "Q32LN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN0/entry#names_and_taxonomy" } ] }, { "name": "ETS domain-containing transcription factor", "type": "synonym", "evidence": [ { "id": "NP_001033125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033125" }, { "id": "Q32LN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN0/entry#names_and_taxonomy" } ] }, { "name": "ETS homologous factor", "type": "synonym", "evidence": [ { "id": "NP_001033125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033125" } ] } ], "function": [ { "annotation": "Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EHF", "url": "https://www.uniprot.org/uniprotkb/Q32LN0", "locus": { "chromosome": "15", "start_pos": 65226451, "end_pos": 65195902, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017150", "url": "https://www.ensembl.org/id/ENSBTAG00000017150" } ] } } ], "crossref": [ { "id": "Q32LN0", "url": "https://alphafold.ebi.ac.uk/entry/Q32LN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505422", "url": "https://www.ncbi.nlm.nih.gov/gene/505422", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505422", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505422", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMDSKTF", "url": "https://omabrowser.org/oma/group/MMDSKTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LN0", "url": "https://www.orthodb.org/?gene=Q32LN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033125", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3F3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXX8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXX8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LN0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILEGSGVMNLNPSNNLLHQQPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDVNGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTDPSIMNTWKEENYLYDTNYGSTVDLLDSKTFCRAQISMTTTGHLPIAESPDTKKEQDHPTKPHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300, "header": "sp|Q32LN0-1|EHF_BOVIN Isoform 1 of ETS homologous factor OS=Bos taurus OX=9913 GN=EHF PE=2 SV=1 CANONICAL=Q32LN0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z3F3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN0/entry#A0AAF6Z3F3-1", "sequence": { "sequence": "MSESTQLALEIMILEGSGVMNLNPSNNLLHQQPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDVNGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTDPSIMNTWKEENYLYDTNYGSTVDLLDSKTFCRAQISMTTTGHLPIAESPDTKKEQDHPTKPHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 311, "header": "tr|A0AAF6Z3F3-1|A0AAF6Z3F3_BOVIN Computationally mapped isoform of ETS homologous factor OS=Bos taurus OX=9913 GN=EHF PE=3 SV=1 CANONICAL=Q32LN0-1" }, "locus": { "chromosome": "15", "start_pos": 65226208, "end_pos": 65195985, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022792.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022792.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022792.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022792.4" } ] } }, { "isoform_ac": "A0ABI0NXX8-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN0/entry#A0ABI0NXX8-1", "sequence": { "sequence": "MILEGSGVMNLNPSNNLLHQQPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDVNGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTDPSIMNTWKEENYLYDTNYGSTVAESPDTKKEQDHPTKPHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 277, "header": "tr|A0ABI0NXX8-1|A0ABI0NXX8_BOVIN Computationally mapped isoform of ETS homologous factor OS=Bos taurus OX=9913 GN=EHF PE=3 SV=1 CANONICAL=Q32LN0-1" }, "locus": { "chromosome": "15", "start_pos": 65226208, "end_pos": 65208499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138518.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138518.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106195.1" } ] } }, { "isoform_ac": "Q32LN0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LN0/entry#Q32LN0-1", "sequence": { "sequence": "MILEGSGVMNLNPSNNLLHQQPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDVNGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTDPSIMNTWKEENYLYDTNYGSTVDLLDSKTFCRAQISMTTTGHLPIAESPDTKKEQDHPTKPHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300, "header": "sp|Q32LN0-1|EHF_BOVIN Isoform 1 of ETS homologous factor OS=Bos taurus OX=9913 GN=EHF PE=2 SV=1 CANONICAL=Q32LN0-1" }, "locus": { "chromosome": "15", "start_pos": 65226208, "end_pos": 65208499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153959.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153959.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104917.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104917.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505422", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505422", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A398-1", "protein_name": "ETS homologous factor", "gene_name": "EHF", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIMILEGAGRMSINSSSNLLHQQPSWTDGYSTCNVSSSFYGTQWHEIHPQYWTKFQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTQAAGTAGQLLYSNLQHLKWNGQCGSDMYQSHNVVVKTEQTDPSLMVSWKEDNYLYDSGYGSTVELLDSKTFCRAQISMTTPSHQPPDSSDVKKTQDHTPKSHTKKHNPRGTHLWEFIRDILLNPEKYPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300 }, "evidence": [ { "id": "Q32LN0", "url": "https://omabrowser.org/oma/group/Q32LN0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RYD8-1", "protein_name": "ETS homologous factor", "gene_name": "Ehf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILEGSGVMNLNPANNLLHQPPAWTDSYSACNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDISGEHLCSMSLQEFTRAAGSAGQLLYSNLQHLKWNGQCSSDLFQSAHNVIVKTEQTDPSIMNTWKEENYLYDPSYGSTVDLLDSKTFCRAQISMTTSSHLPVAESPDMKKEQDHPVKSHTKKHNPRGTHLWEFIRDILLSPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300 }, "evidence": [ { "id": "Q32LN0", "url": "https://omabrowser.org/oma/group/Q32LN0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O70273-1", "protein_name": "ETS homologous factor", "gene_name": "Ehf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILEGSGVMNLNPANNLLHQQPAWTDSYPTCNVSSGFFGSQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDISGEHLCSMSLQEFTRAAGSAGQLLYSNLQHLKWNGQCSSDLFQSAHNVIVKTEQTDPSIMNTWKEENYLYDPSYGSTVDLLDSKTFCRAQISMTTSSHLPVAESPDMKKEQDHPVKSHTKKHNPRGTHLWEFIRDILLSPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300 }, "evidence": [ { "id": "Q32LN0", "url": "https://omabrowser.org/oma/group/Q32LN0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZC4-1", "protein_name": "ETS homologous factor", "gene_name": "EHF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN", "length": 300 }, "evidence": [ { "id": "Q32LN0", "url": "https://omabrowser.org/oma/group/Q32LN0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q32LN0", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LN0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 300, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LN0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LN0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" }, { "id": "PRU00237", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00237" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000255", "start_pos": 207, "end_pos": 289, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN0" }, { "id": "PRU00762", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PNT", "eco_id": "ECO_0000255", "start_pos": 29, "end_pos": 115, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LP9-1", "uniprot_ac": "Q32LP9", "uniprot_id": "COR2A_BOVIN", "mass": { "chemical_mass": 59845.0, "monoisotopic_mass": 59845.0 }, "refseq": { "ac": "NP_001033309", "name": "coronin-2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033309" }, "gene_names": [ { "name": "CORO2A", "type": "recommended", "evidence": [ { "id": "Q32LP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ] }, { "name": "CORO2A", "type": "synonym", "evidence": [ { "id": "NP_001033309", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033309" } ] } ], "protein_names": [ { "name": "Coronin-2A", "type": "recommended", "evidence": [ { "id": "Q32LP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LP9/entry#names_and_taxonomy" } ] }, { "name": "coronin, actin binding protein, 2A", "type": "synonym", "evidence": [ { "id": "NP_001033309", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033309" } ] }, { "name": "coronin-2A", "type": "synonym", "evidence": [ { "id": "NP_001033309", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033309" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CORO2A", "url": "https://www.uniprot.org/uniprotkb/Q32LP9", "locus": { "chromosome": "8", "start_pos": 63246399, "end_pos": 63267598, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007659", "url": "https://www.ensembl.org/id/ENSBTAG00000007659" } ] } } ], "crossref": [ { "id": "Q32LP9", "url": "https://alphafold.ebi.ac.uk/entry/Q32LP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617620", "url": "https://www.ncbi.nlm.nih.gov/gene/617620", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617620", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617620", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSCEIFR", "url": "https://omabrowser.org/oma/group/TSCEIFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LP9", "url": "https://www.orthodb.org/?gene=Q32LP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10856", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10856", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10856:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10856:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033309", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LP9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWHPQYRSSKFRHVFGKPASKENCYDSVPITHSVQDNHFCAVNPHFIAVVTECTGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFNDFEIASCSEDATIKIWDIPKQLLTKNLTAFRKELVGHARKVGLVEWHPTAANILFSSGYDYKVMVWNLDSKESVIMSPVKTINCHQDVILSMSFNTNGSLLATACKDRKIRVLDPRAGTVLQEANYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDDLSVPVTEVDLDGSSGVLFPFYDADTNMLYVVGKGDRNIHYYEISANKPHLNYLMEYHSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTASAQPSLTAQEWLSGMNKEPVLMSLRPGAEPLSPQPLPSERTLSMPTAPTSPHLFNQTESLVAEDGRRPFSLLEEKAPRWAAEHRQEEKKTWLSDGFDIFECPPPKTENELLQMFYRQQDEIRRLRELVTQREVQAKQLELEIRNLRMNSPRL", "length": 525, "header": "sp|Q32LP9-1|COR2A_BOVIN Isoform 1 of Coronin-2A OS=Bos taurus OX=9913 GN=CORO2A PE=2 SV=1 CANONICAL=Q32LP9-1" }, "isoforms": [ { "isoform_ac": "Q32LP9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LP9/entry#Q32LP9-1", "sequence": { "sequence": "MSWHPQYRSSKFRHVFGKPASKENCYDSVPITHSVQDNHFCAVNPHFIAVVTECTGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFNDFEIASCSEDATIKIWDIPKQLLTKNLTAFRKELVGHARKVGLVEWHPTAANILFSSGYDYKVMVWNLDSKESVIMSPVKTINCHQDVILSMSFNTNGSLLATACKDRKIRVLDPRAGTVLQEANYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDDLSVPVTEVDLDGSSGVLFPFYDADTNMLYVVGKGDRNIHYYEISANKPHLNYLMEYHSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTASAQPSLTAQEWLSGMNKEPVLMSLRPGAEPLSPQPLPSERTLSMPTAPTSPHLFNQTESLVAEDGRRPFSLLEEKAPRWAAEHRQEEKKTWLSDGFDIFECPPPKTENELLQMFYRQQDEIRRLRELVTQREVQAKQLELEIRNLRMNSPRL", "length": 525, "header": "sp|Q32LP9-1|COR2A_BOVIN Isoform 1 of Coronin-2A OS=Bos taurus OX=9913 GN=CORO2A PE=2 SV=1 CANONICAL=Q32LP9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617620", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617620", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2QC56-1", "protein_name": "Coronin", "gene_name": "Coro2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWNGNSKLRPSPPLLKPNQMSWHPQYRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDIKWNPFDDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELMGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSVISGPVRTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDNLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSTEKPHLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPGSELLDPQALPPERLLSNSVVQVSPQPLEPVKQPAEDGDQAPFSLLEEKVTKWTTEHQLEEKSWLTNGFDIFECPPPKTENELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNLRMVLGQF", "length": 543 }, "evidence": [ { "id": "Q32LP9", "url": "https://omabrowser.org/oma/group/Q32LP9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C0P5-1", "protein_name": "Coronin-2A", "gene_name": "Coro2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSWHPQYRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDIKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSVIAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWNNRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKPHLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPGSELLDSQTLPPERPLSNSMVQVSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTNGFDVFECSPPKTENELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNLRMALGQL", "length": 524 }, "evidence": [ { "id": "Q32LP9", "url": "https://omabrowser.org/oma/group/Q32LP9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q32LP9", "url": "https://www.uniprot.org/uniprotkb/Q32LP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LP9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 525, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LP9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LP9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 191, "end_pos": 193 }, { "start_pos": 428, "end_pos": 430 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LQ1-1", "uniprot_ac": "Q32LQ1", "uniprot_id": "PKHO2_BOVIN", "mass": { "chemical_mass": 54119.0, "monoisotopic_mass": 54119.0 }, "refseq": { "ac": "NP_001069751", "name": "pleckstrin homology domain-containing family O member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" }, "gene_names": [ { "name": "PLEKHO2", "type": "recommended", "evidence": [ { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ] }, { "name": "PLEKHO2", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" } ] }, { "name": "PLEKHQ1", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" }, { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing family O member 2", "type": "recommended", "evidence": [ { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1/entry#names_and_taxonomy" } ] }, { "name": "PH domain-containing family O member 2", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" }, { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1/entry#names_and_taxonomy" } ] }, { "name": "PH domain-containing family Q member 1", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" }, { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1/entry#names_and_taxonomy" } ] }, { "name": "Pleckstrin homology domain-containing family Q member 1", "type": "synonym", "evidence": [ { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1/entry#names_and_taxonomy" } ] }, { "name": "pleckstrin homology domain containing, family O member 2", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" } ] }, { "name": "pleckstrin homology domain containing, family Q member 1", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" } ] }, { "name": "pleckstrin homology domain-containing family O member 2", "type": "synonym", "evidence": [ { "id": "NP_001069751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHO2", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1", "locus": { "chromosome": "10", "start_pos": 45233901, "end_pos": 45256216, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008411", "url": "https://www.ensembl.org/id/ENSBTAG00000008411" } ] } } ], "crossref": [ { "id": "Q32LQ1", "url": "https://alphafold.ebi.ac.uk/entry/Q32LQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd13317", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13317", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613696", "url": "https://www.ncbi.nlm.nih.gov/gene/613696", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613696", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613696", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LQ1", "url": "https://www.orthodb.org/?gene=Q32LQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15871", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15871", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15871:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15871:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069751", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LQ1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEEGVKEGGQRPRSAQTADKAGWIKKSSGGFLGLWKDRYLLLCQAQLLVYENEDEQKCVETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPSGEEKESWIKALNEGINRGKNKAFDEVKVDKSCVLEHVTRDRVRRDQRRRPPTRVHLKEVANAASDGLSRLDLDVPDSGPPVLAPSNDVDAAQPRETPRPPMPPAKPSPAPETSSAGDRMETPVGQSAPAPVPASSEAHPGSQEDLETPVVEDSDSEQPPNRILPDKLKVSWENPSPEEAPDSESAEPPQVPGAETSEAGPREGGKPPTPPPKILSEKLKASMSGMEASGPAQSPGASEASAPGPAEVSVNGVDDSPEPLQSSQAAGPPGTPPKAATTSTTLPPWDLQPQLHPRCSSLGDLLGEGPRRRRQPGEQLHRAQLEVKVASEKTEKLLNKVLGGESASVNAETLLSQAVEQLRQATQVLQEIRDLEEMNREAPGLREKRRELVTLYRRSVP", "length": 499, "header": "sp|Q32LQ1-1|PKHO2_BOVIN Isoform 1 of Pleckstrin homology domain-containing family O member 2 OS=Bos taurus OX=9913 GN=PLEKHO2 PE=2 SV=1 CANONICAL=Q32LQ1-1" }, "isoforms": [ { "isoform_ac": "Q32LQ1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1/entry#Q32LQ1-1", "sequence": { "sequence": "MEEEGVKEGGQRPRSAQTADKAGWIKKSSGGFLGLWKDRYLLLCQAQLLVYENEDEQKCVETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPSGEEKESWIKALNEGINRGKNKAFDEVKVDKSCVLEHVTRDRVRRDQRRRPPTRVHLKEVANAASDGLSRLDLDVPDSGPPVLAPSNDVDAAQPRETPRPPMPPAKPSPAPETSSAGDRMETPVGQSAPAPVPASSEAHPGSQEDLETPVVEDSDSEQPPNRILPDKLKVSWENPSPEEAPDSESAEPPQVPGAETSEAGPREGGKPPTPPPKILSEKLKASMSGMEASGPAQSPGASEASAPGPAEVSVNGVDDSPEPLQSSQAAGPPGTPPKAATTSTTLPPWDLQPQLHPRCSSLGDLLGEGPRRRRQPGEQLHRAQLEVKVASEKTEKLLNKVLGGESASVNAETLLSQAVEQLRQATQVLQEIRDLEEMNREAPGLREKRRELVTLYRRSVP", "length": 499, "header": "sp|Q32LQ1-1|PKHO2_BOVIN Isoform 1 of Pleckstrin homology domain-containing family O member 2 OS=Bos taurus OX=9913 GN=PLEKHO2 PE=2 SV=1 CANONICAL=Q32LQ1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 311, "start_aa": "Thr", "end_pos": 311, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr311", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 373, "start_aa": "Thr", "end_pos": 373, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr373", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Ser167" }, { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Ser237" }, { "start_pos": 238, "end_pos": 238, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Ser238" }, { "start_pos": 273, "end_pos": 273, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Ser273" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Thr298" }, { "start_pos": 311, "end_pos": 311, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Thr311" }, { "start_pos": 399, "end_pos": 399, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "site_lbl": "Ser399" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:613696", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613696", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "macrophage apoptotic process", "id": "GO:0071888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071888", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ1", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LQ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 499, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LQ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LQ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LQ1" }, { "id": "PRU00145", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 119, "start_aa": "Thr", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 311, 373 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 167, 237, 238, 273, 298, 311, 399 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32P59-1", "uniprot_ac": "Q32P59", "uniprot_id": "SLIRP_BOVIN", "mass": { "chemical_mass": 12493.0, "monoisotopic_mass": 12493.0 }, "refseq": { "ac": "NP_001032562", "name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032562" }, "gene_names": [ { "name": "SLIRP", "type": "recommended", "evidence": [ { "id": "Q32P59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ] }, { "name": "C10H14orf156", "type": "synonym", "evidence": [ { "id": "NP_001032562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032562" } ] }, { "name": "SLIRP", "type": "synonym", "evidence": [ { "id": "NP_001032562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032562" } ] } ], "protein_names": [ { "name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q32P59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P59/entry#names_and_taxonomy" } ] }, { "name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001032562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032562" } ] } ], "function": [ { "annotation": "RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59#function" }, { "database": "UniProtKB", "id": "A0A452DJ98", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ98#function" }, { "database": "UniProtKB", "id": "ARBA00057077", "url": "https://www.uniprot.org/uniprotkb/ARBA00057077#function" }, { "database": "UniProtKB", "id": "A0AAA9SHN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLIRP", "url": "https://www.uniprot.org/uniprotkb/Q32P59", "locus": { "chromosome": "10", "start_pos": 88855885, "end_pos": 88846593, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008135", "url": "https://www.ensembl.org/id/ENSBTAG00000008135" } ] } } ], "crossref": [ { "id": "Q32P59", "url": "https://alphafold.ebi.ac.uk/entry/Q32P59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008135", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008135", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12242", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12242", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613614", "url": "https://www.ncbi.nlm.nih.gov/gene/613614", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613614", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613614", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DJ98", "url": "https://www.orthodb.org/?gene=A0A452DJ98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32P59", "url": "https://www.orthodb.org/?gene=Q32P59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11176:SF61", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11176:SF61", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032562", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ98", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ98-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P59-1", "url": "https://www.uniprot.org/uniprotkb/Q32P59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASAARGAMALRTNIGRPVAFVRKIPWTAASSELREHFAQFGHVRKCTVPFDKETGFHKGMGWIHFSSEEELHNALQQENHVIDGVKLHVQPQRPKALQGDQTSDEEKDF", "length": 111, "header": "sp|Q32P59-1|SLIRP_BOVIN Isoform 1 of SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SLIRP PE=3 SV=1 CANONICAL=Q32P59-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ98-1", "url": "https://www.uniprot.org/uniprotkb/Q32P59/entry#A0A452DJ98-1", "sequence": { "sequence": "MAASAARGAVALRTNVGRPVAFVRKIPWTAASSELREHFAQFGHVRKCTVPFDKETGFHKGMGWIHFSSEEELHNALQQENHVIDGVKCLKSPTLRAN", "length": 98, "header": "tr|A0A452DJ98-1|A0A452DJ98_BOVIN Computationally mapped isoform of SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SLIRP PE=4 SV=3 CANONICAL=Q32P59-1" }, "locus": { "chromosome": "10", "start_pos": 88855885, "end_pos": 88846597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043035.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043035.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040631.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040631.4" } ] } }, { "isoform_ac": "A0AAA9SHN7-1", "url": "https://www.uniprot.org/uniprotkb/Q32P59/entry#A0AAA9SHN7-1", "sequence": { "sequence": "MAASAARGAVALRTNVGRPVAFVRKIPWTAASSELREHFAQFGHVRKCTVPFDKETGFHKGMGWIHFSSEEELHNALQQENHVIDGVKLHVQPQRPKALQGDQTSDEEKDF", "length": 111, "header": "tr|A0AAA9SHN7-1|A0AAA9SHN7_BOVIN Computationally mapped isoform of SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SLIRP PE=4 SV=2 CANONICAL=Q32P59-1" }, "locus": { "chromosome": "10", "start_pos": 88853514, "end_pos": 88846597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103779.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103779.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084860.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084860.2" } ] } }, { "isoform_ac": "Q32P59-1", "url": "https://www.uniprot.org/uniprotkb/Q32P59/entry#Q32P59-1", "sequence": { "sequence": "MAASAARGAMALRTNIGRPVAFVRKIPWTAASSELREHFAQFGHVRKCTVPFDKETGFHKGMGWIHFSSEEELHNALQQENHVIDGVKLHVQPQRPKALQGDQTSDEEKDF", "length": 111, "header": "sp|Q32P59-1|SLIRP_BOVIN Isoform 1 of SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SLIRP PE=3 SV=1 CANONICAL=Q32P59-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 104, "end_pos": 104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "site_lbl": "Thr104" }, { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "site_lbl": "Ser105" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613614", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613614", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32P59", "url": "https://www.uniprot.org/uniprotkb/Q32P59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P59-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 111, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P59-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P59" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32P59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P59" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 96, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 104, 105 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P65-1", "uniprot_ac": "Q32P65", "uniprot_id": "NDUF2_BOVIN", "mass": { "chemical_mass": 19658.0, "monoisotopic_mass": 19658.0 }, "refseq": { "ac": "NP_001070497", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" }, "gene_names": [ { "name": "NDUFAF2", "type": "recommended", "evidence": [ { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ] }, { "name": "MMTN", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] }, { "name": "NDUFA12L", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" }, { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ] }, { "name": "NDUFAF2", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2", "type": "recommended", "evidence": [ { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#names_and_taxonomy" } ] }, { "name": "MMTN", "type": "synonym", "evidence": [ { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#names_and_taxonomy" } ] }, { "name": "Mimitin", "type": "synonym", "evidence": [ { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#names_and_taxonomy" } ] }, { "name": "Myc-induced mitochondrial protein", "type": "synonym", "evidence": [ { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] }, { "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 2", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] }, { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] }, { "name": "NDUFA12-like protein", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" }, { "id": "Q32P65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#names_and_taxonomy" } ] }, { "name": "mimitin, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] }, { "name": "myc-induced mitochondrial protein", "type": "synonym", "evidence": [ { "id": "NP_001070497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497" } ] } ], "function": [ { "annotation": "Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone.", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65#function" }, { "database": "UniProtKB", "id": "Q8N183", "url": "https://www.uniprot.org/uniprotkb/Q8N183#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFAF2", "url": "https://www.uniprot.org/uniprotkb/Q32P65", "locus": { "chromosome": "20", "start_pos": 18209414, "end_pos": 18370943, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021607", "url": "https://www.ensembl.org/id/ENSBTAG00000021607" } ] } } ], "crossref": [ { "id": "Q32P65", "url": "https://alphafold.ebi.ac.uk/entry/Q32P65", "database": "AlphaFoldDB", "categories": [] }, { "id": "767961", "url": "https://www.ncbi.nlm.nih.gov/gene/767961", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767961", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767961", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32P65", "url": "https://www.orthodb.org/?gene=Q32P65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32470", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32470", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32470:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32470:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070497", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P65-1", "url": "https://www.uniprot.org/uniprotkb/Q32P65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGWSQRLFGVIRRALSKEVKEQVGTDRFGNKYYYIPEYKNWRGQTIREKRIVEAANKSEIDYEVGDIPTEWEAWIRKTRQTPPTMEEIMKNEKCREEIQMKSQDFYEKEKLLQEESNKELPPPVQTQIKGHASAPYFGKDEPSESPTSTGKTFQPGSWMPHGDKGHSQ", "length": 168, "header": "sp|Q32P65-1|NDUF2_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Bos taurus OX=9913 GN=NDUFAF2 PE=2 SV=1 CANONICAL=Q32P65-1" }, "isoforms": [ { "isoform_ac": "Q32P65-1", "url": "https://www.uniprot.org/uniprotkb/Q32P65/entry#Q32P65-1", "sequence": { "sequence": "MGWSQRLFGVIRRALSKEVKEQVGTDRFGNKYYYIPEYKNWRGQTIREKRIVEAANKSEIDYEVGDIPTEWEAWIRKTRQTPPTMEEIMKNEKCREEIQMKSQDFYEKEKLLQEESNKELPPPVQTQIKGHASAPYFGKDEPSESPTSTGKTFQPGSWMPHGDKGHSQ", "length": 168, "header": "sp|Q32P65-1|NDUF2_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Bos taurus OX=9913 GN=NDUFAF2 PE=2 SV=1 CANONICAL=Q32P65-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "site_lbl": "Ser133" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767961", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767961", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q32P65", "url": "https://www.uniprot.org/uniprotkb/Q32P65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P65-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 168, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P65-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P65" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 133 ], "sequon_annotation_sites": [ { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P66-1", "uniprot_ac": "Q32P66", "uniprot_id": "CZIB_BOVIN", "mass": { "chemical_mass": 18155.0, "monoisotopic_mass": 18155.0 }, "refseq": { "ac": "NP_001033219", "name": "CXXC motif containing zinc binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" }, "gene_names": [ { "name": "CZIB", "type": "recommended", "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ] }, { "name": "C1orf123", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" } ] }, { "name": "C3H1orf123", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" } ] }, { "name": "CZIB", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" } ] } ], "protein_names": [ { "name": "CXXC motif containing zinc binding protein", "type": "recommended", "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66/entry#names_and_taxonomy" } ] }, { "name": "CXXC motif containing zinc binding protein", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" } ] }, { "name": "UPF0587 protein C1orf123 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" }, { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66/entry#names_and_taxonomy" } ] }, { "name": "chromosome 3 C1orf123 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P66", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CZIB", "url": "https://www.uniprot.org/uniprotkb/Q32P66", "locus": { "chromosome": "3", "start_pos": 93022802, "end_pos": 93014858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003484", "url": "https://www.ensembl.org/id/ENSBTAG00000003484" } ] } } ], "crossref": [ { "id": "Q32P66", "url": "https://alphafold.ebi.ac.uk/entry/Q32P66", "database": "AlphaFoldDB", "categories": [] }, { "id": "517857", "url": "https://www.ncbi.nlm.nih.gov/gene/517857", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517857", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517857", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32P66", "url": "https://www.orthodb.org/?gene=Q32P66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12857:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12857:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P66", "url": "https://www.uniprot.org/uniprotkb/Q32P66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P66-1", "url": "https://www.uniprot.org/uniprotkb/Q32P66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKIELQLKATLENVTNLRPVGEDFRWYLKMKCGNCGEISEKWQYIRLMDSVALKGGRGSASMVQKCKLCSRENSIEILSSTIKSYNAEDNEKFKTIVEFECRGLEPVDFQPQAGFAAEGVESGTVFSDINLQEKDWTDYDEKAQESVGIYEVTHQFVKC", "length": 160, "header": "sp|Q32P66-1|CZIB_BOVIN Isoform 1 of CXXC motif containing zinc binding protein OS=Bos taurus OX=9913 GN=CZIB PE=2 SV=1 CANONICAL=Q32P66-1" }, "isoforms": [ { "isoform_ac": "Q32P66-1", "url": "https://www.uniprot.org/uniprotkb/Q32P66/entry#Q32P66-1", "sequence": { "sequence": "MGKIELQLKATLENVTNLRPVGEDFRWYLKMKCGNCGEISEKWQYIRLMDSVALKGGRGSASMVQKCKLCSRENSIEILSSTIKSYNAEDNEKFKTIVEFECRGLEPVDFQPQAGFAAEGVESGTVFSDINLQEKDWTDYDEKAQESVGIYEVTHQFVKC", "length": 160, "header": "sp|Q32P66-1|CZIB_BOVIN Isoform 1 of CXXC motif containing zinc binding protein OS=Bos taurus OX=9913 GN=CZIB PE=2 SV=1 CANONICAL=Q32P66-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32P66", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "site_lbl": "Ser75" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517857", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517857", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32P66", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 160, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P66" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66#function" }, { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "binding_site_uniprot": 33, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 33, "end_pos": 33, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66#function" }, { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "binding_site_uniprot": 36, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 36, "end_pos": 36, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66#function" }, { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "binding_site_uniprot": 67, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 67, "end_pos": 67, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66#function" }, { "id": "Q32P66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P66" } ], "binding_site_uniprot": 70, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 70, "end_pos": 70, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 75 ], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P68-1", "uniprot_ac": "Q32P68", "uniprot_id": "HOATZ_BOVIN", "mass": { "chemical_mass": 19218.0, "monoisotopic_mass": 19218.0 }, "refseq": { "ac": "NP_001070496", "name": "cilia- and flagella-associated protein HOATZ", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" }, "gene_names": [ { "name": "HOATZ", "type": "recommended", "evidence": [ { "id": "Q32P68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ] }, { "name": "C15H11orf88", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] }, { "name": "HOATZ", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein HOATZ", "type": "recommended", "evidence": [ { "id": "Q32P68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P68/entry#names_and_taxonomy" } ] }, { "name": "UPF0722 protein C11orf88 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] }, { "name": "chromosome 15 C11orf88 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] }, { "name": "cilia- and flagella-associated protein HOATZ", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] }, { "name": "protein Hoatz", "type": "synonym", "evidence": [ { "id": "NP_001070496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496" } ] } ], "function": [ { "annotation": "Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4.", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68#function" }, { "database": "UniProtKB", "id": "Q80Y73", "url": "https://www.uniprot.org/uniprotkb/Q80Y73#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOATZ", "url": "https://www.uniprot.org/uniprotkb/Q32P68", "locus": { "chromosome": "15", "start_pos": 21853035, "end_pos": 21818528, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034338", "url": "https://www.ensembl.org/id/ENSBTAG00000034338" } ] } } ], "crossref": [ { "id": "Q32P68", "url": "https://alphafold.ebi.ac.uk/entry/Q32P68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034338", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034338", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767960", "url": "https://www.ncbi.nlm.nih.gov/gene/767960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVCSERQ", "url": "https://omabrowser.org/oma/group/TVCSERQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32P68", "url": "https://www.orthodb.org/?gene=Q32P68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47231:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47231:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070496", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P68-1", "url": "https://www.uniprot.org/uniprotkb/Q32P68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METRPSSSLSSPEESCEAFPQGLLVFTGSSDRDANLAKQFWIGASMYPHNESQLVLSRGSSQRLPVARPSRSSAPEKTYFQPFFLEESKSRDVTAETLKIQESEEKKKYLQKAKKRDEIIQLLRKQREERILKELISLPHKPKGKVHKAKKVISESDKEDQEEVKALD", "length": 168, "header": "sp|Q32P68-1|HOATZ_BOVIN Isoform 1 of Cilia- and flagella-associated protein HOATZ OS=Bos taurus OX=9913 GN=HOATZ PE=2 SV=1 CANONICAL=Q32P68-1" }, "isoforms": [ { "isoform_ac": "Q32P68-1", "url": "https://www.uniprot.org/uniprotkb/Q32P68/entry#Q32P68-1", "sequence": { "sequence": "METRPSSSLSSPEESCEAFPQGLLVFTGSSDRDANLAKQFWIGASMYPHNESQLVLSRGSSQRLPVARPSRSSAPEKTYFQPFFLEESKSRDVTAETLKIQESEEKKKYLQKAKKRDEIIQLLRKQREERILKELISLPHKPKGKVHKAKKVISESDKEDQEEVKALD", "length": 168, "header": "sp|Q32P68-1|HOATZ_BOVIN Isoform 1 of Cilia- and flagella-associated protein HOATZ OS=Bos taurus OX=9913 GN=HOATZ PE=2 SV=1 CANONICAL=Q32P68-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767960", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAL4-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "Hoatz", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METGPRGCPSVRKEPQEICSPGLLVFTGCSEQDANLAKQFWLGASMYPTTESQLVLTRGSSQRLPVARNSKVLVSERNSVKPFPFDHNKEEILFAKAQKVQESEEKANYLQKAKKRDEILQLLRKQREERILKELISLPYKPKAKMPKSEEVLSESDLKDQEEVKALE", "length": 168 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7FSY3-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "Hoatz", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METGHKSSSSCRKDTHEICSPGLLVFTGCSEQDANLAKQFWLGASMYPPAESQLVLTRNSSQRLPVARNSKDLVREKNSAWSFPFDQNKETDVFAKVQKIQESEEKAKFLEKAKKRDEIIQLLRKQREERILKELVSLPHKPKAKVPEAKEVSSESDKQEQEEVKALE", "length": 168 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A5PN52-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "hoatz", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSEELDEEVLDGLTEVEKLYTVFHGASQEDVAYAKLFWNSLSLQPPIESRLVSSDIRQRLKVAKTPNTTNAAANQAPWSKRNEEIQQDAYLRQKQEEKQRYMEMAKNRDQIIALLKKQRDERIKKEMIAYKHKPKKGKLEEKRLAPKTLSSDVDEDQKEVQKLQ", "length": 164 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SUZ8-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "HOATZ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METRPSSGPSSRTESCEICPQGLLVFTGSSDLDANLAKQFWIGASMYPPNESQLVLSRGSSQRLRVARASKSSAPEKSYFQPFFLEKSKNRDGVTETLKIQESEEKKKYLQKAKKRDEIIQLLRKQREERISKELVSLPYKPEAKVHKAKKVISESDKKDREEVKALD", "length": 168 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PI97-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "HOATZ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGPSEEPSGRKESQEMCPPGLLVFAGSSEQDANLAKQFWISASMYPPSESQLVLRRDSSQRLPVARPRRSRGSENSHSSQSFHLASNKNRDIFAEALKIQESEEKVKYLQKAKTREEILQLLRKQREERISKELISLPYKPKAKEHKAKKVVSESDKEDQEEVKTLD", "length": 169 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80Y73-1", "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "Hoatz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METGPRGCPSGRKESQEICSPGLLVFTGCSEQDANLAKQFWLGASMYPTTESQLVLTRGSSQRLPVARNSKVVLREKSSVQPFPFDQDKDAIIFAKAQRIQESEERAKYLQKAKTRDEILQLLRKQREERISKELISLPYKPKDKVPKSKEVLSESGLRDQEEVKALE", "length": 168 }, "evidence": [ { "id": "Q32P68", "url": "https://omabrowser.org/oma/group/Q32P68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q32P68", "url": "https://www.uniprot.org/uniprotkb/Q32P68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 168, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P68" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P76-1", "uniprot_ac": "Q32P76", "uniprot_id": "SERF1_BOVIN", "mass": { "chemical_mass": 7379.0, "monoisotopic_mass": 7379.0 }, "refseq": { "ac": "NP_001106772", "name": "small EDRK-rich factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" }, "gene_names": [ { "name": "SERF1", "type": "recommended", "evidence": [ { "id": "Q32P76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P76" } ] }, { "name": "SERF1A", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] }, { "name": "SERF1B", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] }, { "name": "SERF1", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] } ], "protein_names": [ { "name": "Small EDRK-rich factor 1", "type": "recommended", "evidence": [ { "id": "Q32P76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P76/entry#names_and_taxonomy" } ] }, { "name": "small EDRK-rich factor 1A (telomeric)", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] }, { "name": "small EDRK-rich factor 1B (centromeric)", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] }, { "name": "small EDRK-rich factor 1", "type": "synonym", "evidence": [ { "id": "NP_001106772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772" } ] } ], "function": [ { "annotation": "Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32P76", "url": "https://www.uniprot.org/uniprotkb/Q32P76#function" }, { "database": "UniProtKB", "id": "O75920", "url": "https://www.uniprot.org/uniprotkb/O75920#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P76", "url": "https://www.uniprot.org/uniprotkb/Q32P76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERF1", "url": "https://www.uniprot.org/uniprotkb/Q32P76", "locus": {} } ], "crossref": [ { "id": "Q32P76", "url": "https://alphafold.ebi.ac.uk/entry/Q32P76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034360", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034360", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526395", "url": "https://www.ncbi.nlm.nih.gov/gene/526395", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526395", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526395", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DJE8", "url": "https://www.orthodb.org/?gene=A0A452DJE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32P76", "url": "https://www.orthodb.org/?gene=Q32P76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13596", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13596", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13596:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13596:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04419", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04419", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001106772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJE8", "url": "https://www.uniprot.org/uniprotkb/A0A452DJE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P76", "url": "https://www.uniprot.org/uniprotkb/Q32P76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P76-1", "url": "https://www.uniprot.org/uniprotkb/Q32P76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARGNQRELARQKNMKKSQEISKGKRKEDSLTTSQRKQRDSEIMQQKQKAANERKSMQTREK", "length": 62, "header": "sp|Q32P76-1|SERF1_BOVIN Isoform 1 of Small EDRK-rich factor 1 OS=Bos taurus OX=9913 GN=SERF1 PE=3 SV=1 CANONICAL=Q32P76-1" }, "isoforms": [ { "isoform_ac": "A0A452DJE8-1", "url": "https://www.uniprot.org/uniprotkb/Q32P76/entry#A0A452DJE8-1", "sequence": { "sequence": "PGYRGENPQTPIHLSDSRTRFQDATKLARAKRTLRPTYGATLAAAASEPQQSTAQPRPPGRARAVARRPRRRLLSGLGGRDRRQSPGVSRRGAGGGLVFQINGWGRRLSVRGGRCFSESLSSRLGPVVIMARGNQRELARQKNMKKSQEISKGKRKEDSLTTSQRKQRDSEIMQQKQKAANERKSMQTREK", "length": 191, "header": "tr|A0A452DJE8-1|A0A452DJE8_BOVIN Computationally mapped isoform of Small EDRK-rich factor-like N-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=Q32P76-1" }, "locus": { "chromosome": "20", "start_pos": 10095439, "end_pos": 10091986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048677.3", "url": "https://www.ensembl.org/id/ENSBTAT00000048677.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045674.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045674.3" } ] } }, { "isoform_ac": "Q32P76-1", "url": "https://www.uniprot.org/uniprotkb/Q32P76/entry#Q32P76-1", "sequence": { "sequence": "MARGNQRELARQKNMKKSQEISKGKRKEDSLTTSQRKQRDSEIMQQKQKAANERKSMQTREK", "length": 62, "header": "sp|Q32P76-1|SERF1_BOVIN Isoform 1 of Small EDRK-rich factor 1 OS=Bos taurus OX=9913 GN=SERF1 PE=3 SV=1 CANONICAL=Q32P76-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526395", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526395", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32P76", "url": "https://www.uniprot.org/uniprotkb/Q32P76" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32P76", "url": "https://www.uniprot.org/uniprotkb/Q32P76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P76-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 62, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P76" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P86-1", "uniprot_ac": "Q32P86", "uniprot_id": "DB119_BOVIN", "mass": { "chemical_mass": 9805.0, "monoisotopic_mass": 9805.0 }, "refseq": { "ac": "NP_001095131", "name": "beta-defensin 119 isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" }, "gene_names": [ { "name": "DEFB119", "type": "recommended", "evidence": [ { "id": "Q32P86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P86" } ] }, { "name": "BBD119", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] }, { "name": "DEFB119", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] }, { "name": "DEFB120", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] } ], "protein_names": [ { "name": "Beta-defensin 119", "type": "recommended", "evidence": [ { "id": "Q32P86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P86/entry#names_and_taxonomy" } ] }, { "name": "Defensin, beta 119", "type": "synonym", "evidence": [ { "id": "Q32P86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P86/entry#names_and_taxonomy" } ] }, { "name": "beta-defensin 119 isoform 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] }, { "name": "beta-defensin 119", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] }, { "name": "beta-defensin 120", "type": "synonym", "evidence": [ { "id": "NP_001095131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131" } ] } ], "function": [ { "annotation": "Has antibacterial activity.", "evidence": [ { "database": "UniProtKB", "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DEFB119", "url": "https://www.uniprot.org/uniprotkb/Q32P86", "locus": { "chromosome": "13", "start_pos": 60989366, "end_pos": 60990988, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003364", "url": "https://www.ensembl.org/id/ENSBTAG00000003364" } ] } } ], "crossref": [ { "id": "Q32P86", "url": "https://alphafold.ebi.ac.uk/entry/Q32P86", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003364", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003364", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767957", "url": "https://www.ncbi.nlm.nih.gov/gene/767957", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767957", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767957", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QENRWPK", "url": "https://omabrowser.org/oma/group/QENRWPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32P86", "url": "https://www.orthodb.org/?gene=Q32P86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47902:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47902:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14862", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1461957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1461973", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461973", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095131", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P86-1", "url": "https://www.uniprot.org/uniprotkb/Q32P86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFLFLFLAILLAMEPVVSGRRHMLRCMGDLGICRPACRQSEEPYLYCRNYQPCCLPFYVRIDISGKEGKNDWSRENRWPKVS", "length": 83, "header": "sp|Q32P86-1|DB119_BOVIN Isoform 1 of Beta-defensin 119 OS=Bos taurus OX=9913 GN=DEFB119 PE=3 SV=1 CANONICAL=Q32P86-1" }, "isoforms": [ { "isoform_ac": "Q32P86-1", "url": "https://www.uniprot.org/uniprotkb/Q32P86/entry#Q32P86-1", "sequence": { "sequence": "MKFLFLFLAILLAMEPVVSGRRHMLRCMGDLGICRPACRQSEEPYLYCRNYQPCCLPFYVRIDISGKEGKNDWSRENRWPKVS", "length": 83, "header": "sp|Q32P86-1|DB119_BOVIN Isoform 1 of Beta-defensin 119 OS=Bos taurus OX=9913 GN=DEFB119 PE=3 SV=1 CANONICAL=Q32P86-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767957", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767957", "resource": "KEGG Pathway" }, { "id": "R-BTA-1461957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461957", "resource": "Reactome", "description": "Beta defensins" }, { "id": "R-BTA-1461973", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461973", "resource": "Reactome", "description": "Defensins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8K3I8-1", "protein_name": "Beta-defensin 19", "gene_name": "Defb19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLALLLLAILVATELVVSGKNPILQCMGNRGFCRSSCKKSEQAYFYCRTFQMCCLQSYVRISLTGVDDNTNWSYEKHWPRIP", "length": 83 }, "evidence": [ { "id": "Q32P86", "url": "https://omabrowser.org/oma/group/Q32P86/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N690-1", "protein_name": "Beta-defensin 119", "gene_name": "DEFB119", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLLYLFLAILLAIEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCRNCQSCCLQSYMRISISGKEENTDWSYEKQWPRLP", "length": 84 }, "evidence": [ { "id": "Q32P86", "url": "https://omabrowser.org/oma/group/Q32P86/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "Q32P86", "url": "https://www.uniprot.org/uniprotkb/Q32P86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P86-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 83, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P86-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P86" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P97-1", "uniprot_ac": "Q32P97", "uniprot_id": "UXT_BOVIN", "mass": { "chemical_mass": 18083.0, "monoisotopic_mass": 18083.0 }, "refseq": { "ac": "NP_001032548", "name": "protein UXT", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548" }, "gene_names": [ { "name": "UXT", "type": "recommended", "evidence": [ { "id": "Q32P97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ] }, { "name": "UXT", "type": "synonym", "evidence": [ { "id": "NP_001032548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548" } ] } ], "protein_names": [ { "name": "Protein UXT", "type": "recommended", "evidence": [ { "id": "Q32P97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P97/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitously expressed transcript protein", "type": "synonym", "evidence": [ { "id": "Q32P97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P97/entry#names_and_taxonomy" } ] }, { "name": "protein UXT", "type": "synonym", "evidence": [ { "id": "NP_001032548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548" } ] }, { "name": "ubiquitously expressed transcript protein", "type": "synonym", "evidence": [ { "id": "NP_001032548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548" } ] }, { "name": "ubiquitously-expressed transcript", "type": "synonym", "evidence": [ { "id": "NP_001032548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548" } ] } ], "function": [ { "annotation": "Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97#function" }, { "database": "UniProtKB", "id": "Q9UBK9", "url": "https://www.uniprot.org/uniprotkb/Q9UBK9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UXT", "url": "https://www.uniprot.org/uniprotkb/Q32P97", "locus": { "chromosome": "X", "start_pos": 86023688, "end_pos": 86089900, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015820", "url": "https://www.ensembl.org/id/ENSBTAG00000015820" } ] } } ], "crossref": [ { "id": "Q32P97", "url": "https://alphafold.ebi.ac.uk/entry/Q32P97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23158", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23158", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525680", "url": "https://www.ncbi.nlm.nih.gov/gene/525680", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q32P97", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q32P97*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525680", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525680", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMPDGYK", "url": "https://omabrowser.org/oma/group/HMPDGYK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32P97", "url": "https://www.orthodb.org/?gene=Q32P97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032548", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P97-1", "url": "https://www.uniprot.org/uniprotkb/Q32P97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH", "length": 156, "header": "sp|Q32P97-1|UXT_BOVIN Isoform 1 of Protein UXT OS=Bos taurus OX=9913 GN=UXT PE=2 SV=1 CANONICAL=Q32P97-1" }, "isoforms": [ { "isoform_ac": "Q32P97-1", "url": "https://www.uniprot.org/uniprotkb/Q32P97/entry#Q32P97-1", "sequence": { "sequence": "MATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH", "length": 156, "header": "sp|Q32P97-1|UXT_BOVIN Isoform 1 of Protein UXT OS=Bos taurus OX=9913 GN=UXT PE=2 SV=1 CANONICAL=Q32P97-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525680", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525680", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1F7J7-1", "protein_name": "Protein UXT", "gene_name": "UXT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSNLLTELSDSLTKDSMNIKAHIHMLLEGLRELQGLQNFPEPRH", "length": 156 }, "evidence": [ { "id": "Q32P97", "url": "https://omabrowser.org/oma/group/Q32P97/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54ND3-1", "protein_name": "Protein UXT homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVSHSHSHTHQNQKDIEKEKLLKERLDSIKYYETFINETLNVDLNKSIEDREKVLENLENYLELKSNIELLIENKMDSMKTMINLGSECYVKARVQDTSYIYVDIGLGIHVKYTLEEAIKFINEKETFLNKTVENQTKKINQIKTKIDLIQNGLKELKHLE", "length": 161 }, "evidence": [ { "id": "Q32P97", "url": "https://omabrowser.org/oma/group/Q32P97/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q63ZY7-1", "protein_name": "Protein UXT", "gene_name": "Uxt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATPPKRRALDTVGEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTMVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDSLTKDSMNIKANIHMMLEGLRELQGLQNFPEPSPH", "length": 157 }, "evidence": [ { "id": "Q32P97", "url": "https://omabrowser.org/oma/group/Q32P97/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UBK9-1", "protein_name": "Protein UXT", "gene_name": "UXT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATPPKRRAVEATGEKVLRYETFISDVLQRDLRKVLDHRDKVYEQLAKYLQLRNVIERLQEAKHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSNSLTKDSMNIKAHIHMLLEGLRELQGLQNFPEKPHH", "length": 157 }, "evidence": [ { "id": "Q32P97", "url": "https://omabrowser.org/oma/group/Q32P97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WTZ0-1", "protein_name": "Protein UXT", "gene_name": "Uxt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATPPKRRALDTVGEKVLRYETFISDVLQRDLQKVLDHRDKVYEQLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDSLTKDSMNIKAHIHMMLEGLRELQGLQNFPEPSPH", "length": 157 }, "evidence": [ { "id": "Q32P97", "url": "https://omabrowser.org/oma/group/Q32P97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q32P97", "url": "https://www.uniprot.org/uniprotkb/Q32P97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 156, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P97" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PB1-1", "uniprot_ac": "Q32PB1", "uniprot_id": "PROF3_BOVIN", "mass": { "chemical_mass": 14629.0, "monoisotopic_mass": 14629.0 }, "refseq": { "ac": "NP_001071413", "name": "profilin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071413" }, "gene_names": [ { "name": "PFN3", "type": "recommended", "evidence": [ { "id": "Q32PB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ] }, { "name": "PFN3", "type": "synonym", "evidence": [ { "id": "NP_001071413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071413" } ] } ], "protein_names": [ { "name": "Profilin-3", "type": "recommended", "evidence": [ { "id": "Q32PB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB1/entry#names_and_taxonomy" } ] }, { "name": "profilin-3", "type": "synonym", "evidence": [ { "id": "NP_001071413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071413" } ] } ], "function": [ { "annotation": "Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFN3", "url": "https://www.uniprot.org/uniprotkb/Q32PB1", "locus": { "chromosome": "7", "start_pos": 38897537, "end_pos": 38898247, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020353", "url": "https://www.ensembl.org/id/ENSBTAG00000020353" } ] } } ], "crossref": [ { "id": "Q32PB1", "url": "https://alphafold.ebi.ac.uk/entry/Q32PB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020353", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020353", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521379", "url": "https://www.ncbi.nlm.nih.gov/gene/521379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521379", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521379", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VCVGHTP", "url": "https://omabrowser.org/oma/group/VCVGHTP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PB1", "url": "https://www.orthodb.org/?gene=Q32PB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13936", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13936", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13936:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13936:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00235", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00235", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071413", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PB1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRSTFLQAGLCVAGRRCCVIRDHLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTMHELIHGLRSQGT", "length": 137, "header": "sp|Q32PB1-1|PROF3_BOVIN Isoform 1 of Profilin-3 OS=Bos taurus OX=9913 GN=PFN3 PE=2 SV=1 CANONICAL=Q32PB1-1" }, "isoforms": [ { "isoform_ac": "Q32PB1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1/entry#Q32PB1-1", "sequence": { "sequence": "MGDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRSTFLQAGLCVAGRRCCVIRDHLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTMHELIHGLRSQGT", "length": 137, "header": "sp|Q32PB1-1|PROF3_BOVIN Isoform 1 of Profilin-3 OS=Bos taurus OX=9913 GN=PFN3 PE=2 SV=1 CANONICAL=Q32PB1-1" }, "locus": { "chromosome": "7", "start_pos": 38898174, "end_pos": 38897764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027123.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027123.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000054439.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521379", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521379", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HV28-1", "protein_name": "Profilin", "gene_name": "Pfn3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQTGLSVAGRRCCVIRDYLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTVHDLIGGLREQCS", "length": 137 }, "evidence": [ { "id": "Q32PB1", "url": "https://omabrowser.org/oma/group/Q32PB1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BXG1-1", "protein_name": "Profilin", "gene_name": "PFN3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNCWNYYTDCILSDKYIDDVAIVGLSDNKYVWAAKPGGLLSAVSPREVDLITGQDRITFLTAGISIAGKKCIVIRDSLLVEGDNVMDIRSRGGDSRSICIGKTPKALIFLMGNRGVHGGVLNLKIHDMIAGMTL", "length": 134 }, "evidence": [ { "id": "Q32PB1", "url": "https://omabrowser.org/oma/group/Q32PB1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P60673-1", "protein_name": "Profilin-3", "gene_name": "PFN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQAGLSVGGRRCCVIRDHLLAEGDGVLDARTKGLDARAVCVGRAPRALLVLMGRRGVHGGILNKTVHELIRGLRMQGA", "length": 137 }, "evidence": [ { "id": "Q32PB1", "url": "https://omabrowser.org/oma/group/Q32PB1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAD6-1", "protein_name": "Profilin-3", "gene_name": "Pfn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQTGLSVAGRRCCVIRDYLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTVHDLIGGLREQCS", "length": 137 }, "evidence": [ { "id": "Q32PB1", "url": "https://omabrowser.org/oma/group/Q32PB1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of actin filament bundle assembly", "id": "GO:0032233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032233", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q32PB1", "url": "https://www.uniprot.org/uniprotkb/Q32PB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 137, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PB1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PB1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PB9-1", "uniprot_ac": "Q32PB9", "uniprot_id": "RL38_BOVIN", "mass": { "chemical_mass": 8218.0, "monoisotopic_mass": 8218.0 }, "refseq": { "ac": "NP_001106780", "name": "large ribosomal subunit protein eL38", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106780" }, "gene_names": [ { "name": "RPL38", "type": "recommended", "evidence": [ { "id": "Q32PB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ] }, { "name": "RPL38", "type": "synonym", "evidence": [ { "id": "NP_001106780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106780" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL38", "type": "recommended", "evidence": [ { "id": "Q32PB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB9/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L38", "type": "synonym", "evidence": [ { "id": "NP_001106780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106780" }, { "id": "Q32PB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB9/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL38", "type": "synonym", "evidence": [ { "id": "NP_001106780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106780" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9#function" }, { "database": "UniProtKB", "id": "P63173", "url": "https://www.uniprot.org/uniprotkb/P63173#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL38", "url": "https://www.uniprot.org/uniprotkb/Q32PB9", "locus": { "chromosome": "19", "start_pos": 57192382, "end_pos": 57196476, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030164", "url": "https://www.ensembl.org/id/ENSBTAG00000030164" } ] } } ], "crossref": [ { "id": "Q32PB9", "url": "https://alphafold.ebi.ac.uk/entry/Q32PB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615300", "url": "https://www.ncbi.nlm.nih.gov/gene/615300", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6MTD", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6MTD&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6MTE", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6MTE&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615300", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615300", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCHRFIY", "url": "https://omabrowser.org/oma/group/RCHRFIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PB9", "url": "https://www.orthodb.org/?gene=Q32PB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10965:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10965:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006mtd", "url": "https://www.rcsb.org/structure/pdb_00006mtd", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006mte", "url": "https://www.rcsb.org/structure/pdb_00006mte", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MTD", "url": "https://www.rcsb.org/structure/6MTD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MTE", "url": "https://www.rcsb.org/structure/6MTE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PB9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK", "length": 70, "header": "sp|Q32PB9-1|RL38_BOVIN Isoform 1 of Large ribosomal subunit protein eL38 OS=Bos taurus OX=9913 GN=RPL38 PE=1 SV=4 CANONICAL=Q32PB9-1" }, "isoforms": [ { "isoform_ac": "Q32PB9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB9/entry#Q32PB9-1", "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK", "length": 70, "header": "sp|Q32PB9-1|RL38_BOVIN Isoform 1 of Large ribosomal subunit protein eL38 OS=Bos taurus OX=9913 GN=RPL38 PE=1 SV=4 CANONICAL=Q32PB9-1" }, "locus": { "chromosome": "19", "start_pos": 57196195, "end_pos": 57192492, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042547.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042547.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040182.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040182.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615300", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615300", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BU66-1", "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "RPL38", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK", "length": 70 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O22860-1", "protein_name": "Large ribosomal subunit protein eL38z/eL38y", "gene_name": "RPL38B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPKQIHEIKDFLLTARRKDARSVKIKRSKDIVKFKVRCSRYLYTLCVFDQEKADKLKQSLPPGLSVQDL", "length": 69 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P63173-1", "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "RPL38", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK", "length": 70 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P63174-1", "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "Rpl38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK", "length": 70 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JJI8-1", "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "Rpl38", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKDLK", "length": 70 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W5N2-1", "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "RpL38", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPREIKEVKDFLNKARRSDARAVKIKKNPTNTKFKIRCSRFLYTLVVQDKEKADKIKQSLPPGLQVKEVK", "length": 70 }, "evidence": [ { "id": "Q32PB9", "url": "https://omabrowser.org/oma/group/Q32PB9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ], "pmid": "" }, { "name": "protein-RNA complex assembly", "id": "GO:0022618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022618", "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q32PB9", "url": "https://www.uniprot.org/uniprotkb/Q32PB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 70, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PB9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PD8-1", "uniprot_ac": "Q32PD8", "uniprot_id": "LERL1_BOVIN", "mass": { "chemical_mass": 14405.0, "monoisotopic_mass": 14405.0 }, "refseq": { "ac": "NP_001032539", "name": "leptin receptor overlapping transcript-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032539" }, "gene_names": [ { "name": "LEPROTL1", "type": "recommended", "evidence": [ { "id": "Q32PD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ] }, { "name": "LEPROTL1", "type": "synonym", "evidence": [ { "id": "NP_001032539", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032539" } ] } ], "protein_names": [ { "name": "Leptin receptor overlapping transcript-like 1", "type": "recommended", "evidence": [ { "id": "Q32PD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD8/entry#names_and_taxonomy" } ] }, { "name": "leptin receptor overlapping transcript-like 1", "type": "synonym", "evidence": [ { "id": "NP_001032539", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032539" } ] } ], "function": [ { "annotation": "Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8#function" }, { "database": "UniProtKB", "id": "A0ABI0NUA8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUA8#function" }, { "database": "UniProtKB", "id": "ARBA00037298", "url": "https://www.uniprot.org/uniprotkb/ARBA00037298#function" }, { "database": "UniProtKB", "id": "A0ABI0P121", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P121#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LEPROTL1", "url": "https://www.uniprot.org/uniprotkb/Q32PD8", "locus": { "chromosome": "27", "start_pos": 26290168, "end_pos": 26280234, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013581", "url": "https://www.ensembl.org/id/ENSBTAG00000013581" } ] } } ], "crossref": [ { "id": "Q32PD8", "url": "https://alphafold.ebi.ac.uk/entry/Q32PD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013581", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013581", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513036", "url": "https://www.ncbi.nlm.nih.gov/gene/513036", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007262", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007262", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICARCAN", "url": "https://omabrowser.org/oma/group/ICARCAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PD8", "url": "https://www.orthodb.org/?gene=Q32PD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12050:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12050:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032539", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NUA8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUA8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P121", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P121", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P121-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P121-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARANLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131, "header": "sp|Q32PD8-1|LERL1_BOVIN Isoform 1 of Leptin receptor overlapping transcript-like 1 OS=Bos taurus OX=9913 GN=LEPROTL1 PE=2 SV=1 CANONICAL=Q32PD8-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NUA8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD8/entry#A0ABI0NUA8-1", "sequence": { "sequence": "MAGIKGGERRPVQMQRPRGAAWGECVSSQASKTSFRGPVLNWTKHALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARANLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 171, "header": "tr|A0ABI0NUA8-1|A0ABI0NUA8_BOVIN Computationally mapped isoform of Leptin receptor overlapping transcript-like 1 OS=Bos taurus OX=9913 GN=LEPROTL1 PE=3 SV=1 CANONICAL=Q32PD8-1" }, "locus": { "chromosome": "27", "start_pos": 26289965, "end_pos": 26280433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146882.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146882.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107281.1" } ] } }, { "isoform_ac": "A0ABI0P121-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD8/entry#A0ABI0P121-1", "sequence": { "sequence": "MPGVESLISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARANLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131, "header": "tr|A0ABI0P121-1|A0ABI0P121_BOVIN Computationally mapped isoform of Leptin receptor overlapping transcript-like 1 OS=Bos taurus OX=9913 GN=LEPROTL1 PE=3 SV=1 CANONICAL=Q32PD8-1" }, "locus": { "chromosome": "27", "start_pos": 26289965, "end_pos": 26285696, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147026.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147026.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104657.1" } ] } }, { "isoform_ac": "Q32PD8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD8/entry#Q32PD8-1", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARANLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131, "header": "sp|Q32PD8-1|LERL1_BOVIN Isoform 1 of Leptin receptor overlapping transcript-like 1 OS=Bos taurus OX=9913 GN=LEPROTL1 PE=2 SV=1 CANONICAL=Q32PD8-1" }, "locus": { "chromosome": "27", "start_pos": 26289965, "end_pos": 26280433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136866.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136866.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107610.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513036", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513036", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140T8I0-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "LEPROTL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGIKALISLSFGGAVGLMFLMLGCALPQYNQYWPLFVLFFYILSPIPYCIARRLVDDTDATSNACKELAVFLTTGIVVSAFGLPIVFARAELIYWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A5G2Q7T8-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "LEPROTL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H618-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "Leprotl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPVVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95214-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "LEPROTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNKYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47111-1", "protein_name": "Vacuolar protein sorting-associated protein 55", "gene_name": "VPS55", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MMEFKVSPLTKIISLSGFLALGFLLVILSCALFHNYYPLFDILIFLLAPIPNTIFNAGNKYHTSDFMSDSSNTGQDLAHFLTGMLVTSGIALPVVFYHCQLIGHLSCIMCMIGGLIIYSSIVIFKWFFKKDFNEDDSLFG", "length": 140 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54VP1-1", "protein_name": "Vacuolar protein sorting-associated protein 55 homolog", "gene_name": "vps55", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGHDIKGFSCAFAVGLLFNILACIVSHSGYPIIVVASYFLAPFPNILCRNRDSFSSEKGTFEDIGLFLTGLFITSGFAIPMILAHSDIISGKALAFSMAGGVTVYATIITFLWFFNRHNDEDNNW", "length": 125 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PDU4-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "Leprotl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGVVVSAFGLPVVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8MMD0-1", "protein_name": "Leptin receptor gene-related protein", "gene_name": "BcDNA:RH04491", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATLKALFICAFLTCIGVTFLILACAVPTTKIFYPFFVLLFYVLSVLPVFIARRTTPGNETNPKSEFAHFLTAGMVLSAFALPIVLAHALVITWTASILTIISNIINYGTIFWYAMRDDEPYGSMF", "length": 126 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9AST6-1", "protein_name": "Vacuolar protein sorting-associated protein 55 homolog", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADVPGYLRTCLDMGKIAFLAILVSTGIVLQILACALFNNWWPMLSVIMYVLLPMPLLFFGGSDSTSLFNESDNSWINAAKFLTGASAVGSVAIPSILKHAGLIGWGALALDLSSYVVFLVAILGYICIGDASDNYYSYI", "length": 140 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CQ74-1", "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "Leprotl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPVVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW", "length": 131 }, "evidence": [ { "id": "Q32PD8", "url": "https://omabrowser.org/oma/group/Q32PD8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of growth hormone receptor signaling pathway", "id": "GO:0060400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060400", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "pmid": "" }, { "name": "late endosome to vacuole transport via multivesicular body sorting pathway", "id": "GO:0032511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032511", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32PD8", "url": "https://www.uniprot.org/uniprotkb/Q32PD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PD8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 131, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PD8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PD8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PD9-1", "uniprot_ac": "Q32PD9", "uniprot_id": "SMCO4_BOVIN", "mass": { "chemical_mass": 6738.0, "monoisotopic_mass": 6738.0 }, "refseq": { "ac": "NP_001289597", "name": "single-pass membrane and coiled-coil domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597" }, "gene_names": [ { "name": "SMCO4", "type": "recommended", "evidence": [ { "id": "Q32PD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD9" } ] }, { "name": "C11orf75", "type": "synonym", "evidence": [ { "id": "NP_001289597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597" } ] }, { "name": "C29H11orf75", "type": "synonym", "evidence": [ { "id": "NP_001289597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597" } ] }, { "name": "SMCO4", "type": "synonym", "evidence": [ { "id": "NP_001289597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597" } ] } ], "protein_names": [ { "name": "Single-pass membrane and coiled-coil domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q32PD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD9/entry#names_and_taxonomy" } ] }, { "name": "single-pass membrane and coiled-coil domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001289597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PD9", "url": "https://www.uniprot.org/uniprotkb/Q32PD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMCO4", "url": "https://www.uniprot.org/uniprotkb/Q32PD9", "locus": { "chromosome": "29", "start_pos": 1378453, "end_pos": 1302373, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033621", "url": "https://www.ensembl.org/id/ENSBTAG00000033621" } ] } } ], "crossref": [ { "id": "Q32PD9", "url": "https://alphafold.ebi.ac.uk/entry/Q32PD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033621", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033621", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614071", "url": "https://www.ncbi.nlm.nih.gov/gene/614071", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614071", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614071", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FFIYANT", "url": "https://omabrowser.org/oma/group/FFIYANT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PD9", "url": "https://www.orthodb.org/?gene=Q32PD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34644", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34644", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34644:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34644:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001289597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PD9", "url": "https://www.uniprot.org/uniprotkb/Q32PD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQLKGKPKKETSRDKKERKQAMQEARRQITTVVLPTLAVVVLLIVVFVYVATRPASTE", "length": 59, "header": "sp|Q32PD9-1|SMCO4_BOVIN Isoform 1 of Single-pass membrane and coiled-coil domain-containing protein 4 OS=Bos taurus OX=9913 GN=SMCO4 PE=3 SV=1 CANONICAL=Q32PD9-1" }, "isoforms": [ { "isoform_ac": "Q32PD9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD9/entry#Q32PD9-1", "sequence": { "sequence": "MRQLKGKPKKETSRDKKERKQAMQEARRQITTVVLPTLAVVVLLIVVFVYVATRPASTE", "length": 59, "header": "sp|Q32PD9-1|SMCO4_BOVIN Isoform 1 of Single-pass membrane and coiled-coil domain-containing protein 4 OS=Bos taurus OX=9913 GN=SMCO4 PE=3 SV=1 CANONICAL=Q32PD9-1" }, "locus": { "chromosome": "29", "start_pos": 1377359, "end_pos": 1377183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047769.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047769.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044942.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614071", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614071", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FNY6-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "SMCO4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVVLIVVFVYVATRPTITE", "length": 59 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FVK8-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "Smco4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIAEESQEQTQRCAGSASRRCSNLDCLSGLGQLTVRSSPGSWRRITQITLTGSRLTDITEFEVKRPPAWTEDCGPSSKTSLGTSSHHHLAKMRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPTVTE", "length": 150 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8SY72-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRQLKGKVKETRKQKKERKLDNLETQAKIRTVVLPALGVLAVFLVLFVYLKTRPAVLA", "length": 58 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9JIS3-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "Smco4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPAVTE", "length": 59 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRQ5-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "SMCO4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPTITE", "length": 59 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GG67-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "SMCO4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRQLRGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPNTTE", "length": 59 }, "evidence": [ { "id": "Q32PD9", "url": "https://omabrowser.org/oma/group/Q32PD9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32PD9", "url": "https://www.uniprot.org/uniprotkb/Q32PD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 59, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PD9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PE7-1", "uniprot_ac": "Q32PE7", "uniprot_id": "BAFL_BOVIN", "mass": { "chemical_mass": 10358.0, "monoisotopic_mass": 10358.0 }, "refseq": { "ac": "NP_001035649", "name": "barrier-to-autointegration factor-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649" }, "gene_names": [ { "name": "BANF2", "type": "recommended", "evidence": [ { "id": "Q32PE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ] }, { "name": "BAF-L", "type": "synonym", "evidence": [ { "id": "NP_001035649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649" } ] }, { "name": "BAFL", "type": "synonym", "evidence": [ { "id": "Q32PE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ] }, { "name": "BANF2", "type": "synonym", "evidence": [ { "id": "NP_001035649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649" } ] } ], "protein_names": [ { "name": "Barrier-to-autointegration factor-like protein", "type": "recommended", "evidence": [ { "id": "Q32PE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE7/entry#names_and_taxonomy" } ] }, { "name": "BAF-L", "type": "synonym", "evidence": [ { "id": "Q32PE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE7/entry#names_and_taxonomy" } ] }, { "name": "Barrier-to-autointegration factor 2", "type": "synonym", "evidence": [ { "id": "Q32PE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE7/entry#names_and_taxonomy" } ] }, { "name": "barrier to autointegration factor 2", "type": "synonym", "evidence": [ { "id": "NP_001035649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649" } ] }, { "name": "barrier-to-autointegration factor-like protein", "type": "synonym", "evidence": [ { "id": "NP_001035649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649" } ] } ], "function": [ { "annotation": "May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7#function" }, { "database": "UniProtKB", "id": "A0AAF6YM89", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM89#function" }, { "database": "UniProtKB", "id": "ARBA00059723", "url": "https://www.uniprot.org/uniprotkb/ARBA00059723#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BANF2", "url": "https://www.uniprot.org/uniprotkb/Q32PE7", "locus": { "chromosome": "13", "start_pos": 38080184, "end_pos": 38043770, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004474", "url": "https://www.ensembl.org/id/ENSBTAG00000004474" } ] } } ], "crossref": [ { "id": "Q32PE7", "url": "https://alphafold.ebi.ac.uk/entry/Q32PE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004474", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004474", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538599", "url": "https://www.ncbi.nlm.nih.gov/gene/538599", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538599", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538599", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PE7", "url": "https://www.orthodb.org/?gene=Q32PE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47507", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47507", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47507:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47507:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02961", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02961", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035649", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YM89", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PE7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDHMSPRLRAFLSEPIGEKDVAWVDGISHELAINLVTKGFNKAYVLLGQFLLMHKREAEFQKWLICCCGATEFEARECSNCLKEWCSCFL", "length": 90, "header": "sp|Q32PE7-1|BAFL_BOVIN Isoform 1 of Barrier-to-autointegration factor-like protein OS=Bos taurus OX=9913 GN=BANF2 PE=3 SV=1 CANONICAL=Q32PE7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM89-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE7/entry#A0AAF6YM89-1", "sequence": { "sequence": "EPGGTKEDMDHMSPRLRAFLSEPIGEKDVAWVDGISHELAINLVTKGFNKAYVLLGQFLLMHKREAEFQKWLICCCGATEFEARECSNCLKEWCSCFL", "length": 98, "header": "tr|A0AAF6YM89-1|A0AAF6YM89_BOVIN Computationally mapped isoform of Barrier-to-autointegration factor-like protein OS=Bos taurus OX=9913 GN=BANF2 PE=4 SV=1 CANONICAL=Q32PE7-1" }, "locus": { "chromosome": "13", "start_pos": 38080041, "end_pos": 38043770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152916.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152916.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104761.1" } ] } }, { "isoform_ac": "Q32PE7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE7/entry#Q32PE7-1", "sequence": { "sequence": "MDHMSPRLRAFLSEPIGEKDVAWVDGISHELAINLVTKGFNKAYVLLGQFLLMHKREAEFQKWLICCCGATEFEARECSNCLKEWCSCFL", "length": 90, "header": "sp|Q32PE7-1|BAFL_BOVIN Isoform 1 of Barrier-to-autointegration factor-like protein OS=Bos taurus OX=9913 GN=BANF2 PE=3 SV=1 CANONICAL=Q32PE7-1" }, "locus": { "chromosome": "13", "start_pos": 38080041, "end_pos": 38074242, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005871.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005871.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005871.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005871.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538599", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538599", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UV79-1", "protein_name": "Barrier-to-autointegration factor-like protein", "gene_name": "BANF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDHMSPRLRAFLSEPIGEKDVAWIAGISRELAINLVTKGFNKAYILLGQFLLMHKNEAEFQKWLICCCGATECEAQESSNCLKEWCSCFL", "length": 90 }, "evidence": [ { "id": "Q32PE7", "url": "https://omabrowser.org/oma/group/Q32PE7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BVR0-1", "protein_name": "Barrier-to-autointegration factor-like protein", "gene_name": "Banf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDDMSPRLRAFLSEPIGEKDVAWVDGISRELAINLVTKGFNKAYVLLGQFLLMHKNEAEFQRWIICCCGATECEARQSSTCLKEWCSCFL", "length": 90 }, "evidence": [ { "id": "Q32PE7", "url": "https://omabrowser.org/oma/group/Q32PE7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H503-1", "protein_name": "Barrier-to-autointegration factor-like protein", "gene_name": "BANF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDNMSPRLRAFLSEPIGEKDVCWVDGISHELAINLVTKGINKAYILLGQFLLMHKNEAEFQRWLICCFGATECEAQQTSHCLKEWCACFL", "length": 90 }, "evidence": [ { "id": "Q32PE7", "url": "https://omabrowser.org/oma/group/Q32PE7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "pmid": "" }, { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "Q32PE7", "url": "https://www.uniprot.org/uniprotkb/Q32PE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PE7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 90, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PE7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PE7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PF7-1", "uniprot_ac": "Q32PF7", "uniprot_id": "CA174_BOVIN", "mass": { "chemical_mass": 24768.0, "monoisotopic_mass": 24768.0 }, "refseq": { "ac": "NP_001073258", "name": "UPF0688 protein C1orf174 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073258" }, "gene_names": [ { "name": "C16H1orf174", "type": "recommended", "evidence": [ { "id": "Q32PF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF7" } ] }, { "name": "C16H1orf174", "type": "synonym", "evidence": [ { "id": "NP_001073258", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073258" } ] }, { "name": "C1orf174", "type": "synonym", "evidence": [ { "id": "NP_001073258", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073258" } ] } ], "protein_names": [ { "name": "UPF0688 protein C1orf174 homolog", "type": "recommended", "evidence": [ { "id": "Q32PF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#names_and_taxonomy" } ] }, { "name": "UPF0688 protein C1orf174 homolog", "type": "synonym", "evidence": [ { "id": "NP_001073258", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073258" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PF7", "url": "https://www.uniprot.org/uniprotkb/Q32PF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q32PF7", "locus": {} } ], "crossref": [ { "id": "Q32PF7", "url": "https://alphafold.ebi.ac.uk/entry/Q32PF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024520", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024520", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616142", "url": "https://www.ncbi.nlm.nih.gov/gene/616142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616142", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616142", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FKYDRGH", "url": "https://omabrowser.org/oma/group/FKYDRGH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DKA0", "url": "https://www.orthodb.org/?gene=A0A452DKA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q32PF7", "url": "https://www.orthodb.org/?gene=Q32PF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28491", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28491", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28491:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28491:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073258", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DKA0", "url": "https://www.uniprot.org/uniprotkb/A0A452DKA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DKA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DKA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5D8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5D8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF7", "url": "https://www.uniprot.org/uniprotkb/Q32PF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSRKLAGGVRSSARLRARSCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 237, "header": "sp|Q32PF7-1|CA174_BOVIN Isoform 1 of UPF0688 protein C1orf174 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32PF7-1" }, "isoforms": [ { "isoform_ac": "A0A452DKA0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#A0A452DKA0-1", "sequence": { "sequence": "MAAEKPQGRSPSQTWPSPRPHVKRRLCWITYLGTPSCDWPVFWWRHTPRREPRAAGSLLRWKGLGWARGLGCGAGSGNAPLTLMRSRKLAGGVRSSARLRARSCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 320, "header": "tr|A0A452DKA0-1|A0A452DKA0_BOVIN Computationally mapped isoform of Chromosome 16 C1orf174 homolog OS=Bos taurus OX=9913 GN=C16H1orf174 PE=3 SV=1 CANONICAL=Q32PF7-1" }, "locus": { "chromosome": "16", "start_pos": 49211034, "end_pos": 49205431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044812.3", "url": "https://www.ensembl.org/id/ENSBTAT00000044812.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042269.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042269.2" } ] } }, { "isoform_ac": "A0AAA9S5D8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#A0AAA9S5D8-1", "sequence": { "sequence": "MELAGGVRSSARLRARSCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 234, "header": "tr|A0AAA9S5D8-1|A0AAA9S5D8_BOVIN Computationally mapped isoform of Chromosome 16 C1orf174 homolog OS=Bos taurus OX=9913 GN=C16H1orf174 PE=3 SV=1 CANONICAL=Q32PF7-1" }, "locus": { "chromosome": "16", "start_pos": 49211034, "end_pos": 49206153, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092108.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092108.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078450.1" } ] } }, { "isoform_ac": "A0AAA9SRR7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#A0AAA9SRR7-1", "sequence": { "sequence": "SRSRLRCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 223, "header": "tr|A0AAA9SRR7-1|A0AAA9SRR7_BOVIN Computationally mapped isoform of Chromosome 16 C1orf174 homolog OS=Bos taurus OX=9913 GN=C16H1orf174 PE=3 SV=1 CANONICAL=Q32PF7-1" }, "locus": { "chromosome": "16", "start_pos": 49211034, "end_pos": 49208403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115401.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115401.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089078.1" } ] } }, { "isoform_ac": "A0AAA9TYG2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#A0AAA9TYG2-1", "sequence": { "sequence": "RWAVPGRSLPRAQRLVSPGSGGPKTRQTSASSVDLAPWRRRPRPRPGTQKLAGGVRSSARLRARSCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 282, "header": "tr|A0AAA9TYG2-1|A0AAA9TYG2_BOVIN Computationally mapped isoform of Chromosome 16 C1orf174 homolog OS=Bos taurus OX=9913 GN=C16H1orf174 PE=3 SV=1 CANONICAL=Q32PF7-1" }, "locus": { "chromosome": "16", "start_pos": 49211034, "end_pos": 49204812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129865.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129865.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103390.1" } ] } }, { "isoform_ac": "Q32PF7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF7/entry#Q32PF7-1", "sequence": { "sequence": "MRSRKLAGGVRSSARLRARSCSAASASAQDTHVTTSAQTACQTPSSHKATDRRTSKKFKYDKGHIVKSELQKHRSDSAATPSETPGTHEPLASAEDGASLLGKEAGGSTPQGTAGPLPGRCGTESDASPAETENEPLPPRHGAPVGGESNGGCPARDGAALDLEQGPGAPLLMDGSALLDDDSNQPMPVSRFFGNVELMQDLPPVSSSCPSMSRREFRKMHFRAKDDEEDDADGAET", "length": 237, "header": "sp|Q32PF7-1|CA174_BOVIN Isoform 1 of UPF0688 protein C1orf174 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q32PF7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 80, "start_aa": "Thr", "end_pos": 80, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr80", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF7", "url": "https://www.uniprot.org/uniprotkb/Q32PF7" } ], "site_lbl": "Ser183" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616142", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616142", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1P3V9-1", "protein_name": "Chromosome 1 open reading frame 174", "gene_name": "C1orf174", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGGQARAEAANGAGGGRSRQTSSHKAAGKRPSKRLKCERNSRVKSGLEGCMCGIENPPTPEAPAEGSPSKGTGDRHVIQLEKSESIPETGGEKQEKEHGISSKPPAGKSSSAPSKTESSENLQDCACREEESSCESLLLEGTCLKDEDVPKKLAELDNSAFLDEDSNQPMPLDRFFGNIDFIQDQPAAVLPSTTMSRREYRRLHFIAKEDEEEDEDVL", "length": 220 }, "evidence": [ { "id": "Q32PF7", "url": "https://omabrowser.org/oma/group/Q32PF7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5M951-1", "protein_name": "UPF0688 protein C1orf174 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSRKLTGGVRSSARLRARSCSSTSLASAGDIASSTSAKTTCLASSSHKATDRRTSKKFKYDKGHLLKAELQKVDPKSDISSLPKVVPVAPCENKFAEDGAEAAVPAPENTAPPQGCSKPVSEEPSVKAEEGLPTAPRSAAAAQETHDSSASQAEPVPVLQMDSSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDEDAEG", "length": 222 }, "evidence": [ { "id": "Q32PF7", "url": "https://omabrowser.org/oma/group/Q32PF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80WR5-1", "protein_name": "UPF0688 protein C1orf174 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSRKLTGGVRSSARLRARSYSSASLASARDVTSSTSAKTTCLASSSHKATDRRTSKKFKYDKGHLVKAELQKLDPKSDISSLPKVAPVAPCENKFAEDSAEAAVSVPESREPPQGCSTPASEEPSVKAENGLSTEPSSAAAAQEPDDSSAGQAEPVPRTEEVRASVLQMDSSIFLDDDSNQPMPVSRFFGNVELMQDLPPASSSYPSMSRREFRKMHFRAKDDEDDAEG", "length": 230 }, "evidence": [ { "id": "Q32PF7", "url": "https://omabrowser.org/oma/group/Q32PF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYL3-1", "protein_name": "UPF0688 protein C1orf174", "gene_name": "C1orf174", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLTSSSHKATDTRTSKKFKCDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSALLPGSEAGVSVQQGAASLPLGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQKQNEPGLQTEDVQKPPLQMDNSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDDDDDDDAEM", "length": 243 }, "evidence": [ { "id": "Q32PF7", "url": "https://omabrowser.org/oma/group/Q32PF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PF7", "url": "https://www.uniprot.org/uniprotkb/Q32PF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 237, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 80 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 183 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PG5-1", "uniprot_ac": "Q32PG5", "uniprot_id": "SCND1_BOVIN", "mass": { "chemical_mass": 18688.0, "monoisotopic_mass": 18688.0 }, "refseq": { "ac": "NP_001073059", "name": "SCAN domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073059" }, "gene_names": [ { "name": "SCAND1", "type": "recommended", "evidence": [ { "id": "Q32PG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG5" } ] }, { "name": "SCAND1", "type": "synonym", "evidence": [ { "id": "NP_001073059", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073059" } ] } ], "protein_names": [ { "name": "SCAN domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q32PG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG5/entry#names_and_taxonomy" } ] }, { "name": "SCAN domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001073059", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073059" } ] } ], "function": [ { "annotation": "May regulate transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q32PG5", "url": "https://www.uniprot.org/uniprotkb/Q32PG5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PG5", "url": "https://www.uniprot.org/uniprotkb/Q32PG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCAND1", "url": "https://www.uniprot.org/uniprotkb/Q32PG5", "locus": { "chromosome": "13", "start_pos": 65084902, "end_pos": 65086853, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005573", "url": "https://www.ensembl.org/id/ENSBTAG00000005573" } ] } } ], "crossref": [ { "id": "Q32PG5", "url": "https://alphafold.ebi.ac.uk/entry/Q32PG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005573", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005573", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513983", "url": "https://www.ncbi.nlm.nih.gov/gene/513983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513983", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKSEGAC", "url": "https://omabrowser.org/oma/group/EKSEGAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PG5", "url": "https://www.orthodb.org/?gene=Q32PG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073059", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PG5", "url": "https://www.uniprot.org/uniprotkb/Q32PG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PG5-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATEQSLAPAGSSAPPSGKEEGAGPSSGTEGDPAGSSSTPEAPSIPDSSNPSATVPEANVKPPAAGSAALDLPIGPAPQGPAPVAEASPRSPPGPGGSRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRLRRRTDVRITG", "length": 178, "header": "sp|Q32PG5-1|SCND1_BOVIN Isoform 1 of SCAN domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCAND1 PE=2 SV=1 CANONICAL=Q32PG5-1" }, "isoforms": [ { "isoform_ac": "Q32PG5-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG5/entry#Q32PG5-1", "sequence": { "sequence": "MAATEQSLAPAGSSAPPSGKEEGAGPSSGTEGDPAGSSSTPEAPSIPDSSNPSATVPEANVKPPAAGSAALDLPIGPAPQGPAPVAEASPRSPPGPGGSRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRLRRRTDVRITG", "length": 178, "header": "sp|Q32PG5-1|SCND1_BOVIN Isoform 1 of SCAN domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCAND1 PE=2 SV=1 CANONICAL=Q32PG5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513983", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513983", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A6K0-1", "protein_name": "SCAN domain-containing protein 1", "gene_name": "Scand1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPQPSQAAQSPAAPPEQEEGAGDCAAREPDSMSSPAPELPGAPAALNTAPQADAAPRPGASRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLQAILPEAARARRLRRRPDVRITG", "length": 142 }, "evidence": [ { "id": "Q32PG5", "url": "https://omabrowser.org/oma/group/Q32PG5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S487-1", "protein_name": "SCAN domain-containing protein 1", "gene_name": "SCAND1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAATELSLAATGSLALPLGKEEGAGPSSGPERDSADSFSTPEAPPPAPKPSSPKAEVAEENPTPHSAASASLELPLGPAALGSASFAEAAPRSPPGPGGSRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRLRRRTDVRITG", "length": 179 }, "evidence": [ { "id": "Q32PG5", "url": "https://omabrowser.org/oma/group/Q32PG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P57086-1", "protein_name": "SCAN domain-containing protein 1", "gene_name": "SCAND1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG", "length": 179 }, "evidence": [ { "id": "Q32PG5", "url": "https://omabrowser.org/oma/group/Q32PG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q2M4I6-1", "protein_name": "SCAN domain-containing protein 1", "gene_name": "Scand1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPQPSQDPQSPAAPPEQQEGAGDCAAPSPDSGSSPAPELPGAPAALNTAPYADAALRPGASRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLQAILPEAARARRLRRRADVRITG", "length": 142 }, "evidence": [ { "id": "Q32PG5", "url": "https://omabrowser.org/oma/group/Q32PG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PG5", "url": "https://www.uniprot.org/uniprotkb/Q32PG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PG5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PG5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PG5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG5" }, { "id": "PRU00187", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00187" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000255", "start_pos": 107, "end_pos": 178, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PG9-1", "uniprot_ac": "Q32PG9", "uniprot_id": "FXL12_BOVIN", "mass": { "chemical_mass": 37126.0, "monoisotopic_mass": 37126.0 }, "refseq": { "ac": "NP_001035690", "name": "F-box/LRR-repeat protein 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035690" }, "gene_names": [ { "name": "FBXL12", "type": "recommended", "evidence": [ { "id": "Q32PG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ] }, { "name": "FBXL12", "type": "synonym", "evidence": [ { "id": "NP_001035690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035690" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 12", "type": "recommended", "evidence": [ { "id": "Q32PG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG9/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 12", "type": "synonym", "evidence": [ { "id": "Q32PG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG9/entry#names_and_taxonomy" } ] }, { "name": "F-box/LRR-repeat protein 12", "type": "synonym", "evidence": [ { "id": "NP_001035690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035690" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL12", "url": "https://www.uniprot.org/uniprotkb/Q32PG9", "locus": { "chromosome": "7", "start_pos": 14408570, "end_pos": 14415316, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025148", "url": "https://www.ensembl.org/id/ENSBTAG00000025148" } ] } } ], "crossref": [ { "id": "Q32PG9", "url": "https://alphafold.ebi.ac.uk/entry/Q32PG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025148", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617304", "url": "https://www.ncbi.nlm.nih.gov/gene/617304", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617304", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617304", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RGLPHCM", "url": "https://omabrowser.org/oma/group/RGLPHCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PG9", "url": "https://www.orthodb.org/?gene=Q32PG9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16134:SF153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16134:SF153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PG9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFADLPDSVLLEIFSYLPVRDRIRISRVCHHWKKLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVANLSMVPITSLPCTLRTLELHSCEISMAWLHKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDMGLQELNYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLSVLEGMPALESLCLLGPLVTPEMPSPQEILASCLTMPKLRVLELQGLGWEGQEAERILSKGLPHCMVIVRALPKESMDWWM", "length": 326, "header": "sp|Q32PG9-1|FXL12_BOVIN Isoform 1 of F-box/LRR-repeat protein 12 OS=Bos taurus OX=9913 GN=FBXL12 PE=2 SV=1 CANONICAL=Q32PG9-1" }, "isoforms": [ { "isoform_ac": "Q32PG9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG9/entry#Q32PG9-1", "sequence": { "sequence": "MATFADLPDSVLLEIFSYLPVRDRIRISRVCHHWKKLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVANLSMVPITSLPCTLRTLELHSCEISMAWLHKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDMGLQELNYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLSVLEGMPALESLCLLGPLVTPEMPSPQEILASCLTMPKLRVLELQGLGWEGQEAERILSKGLPHCMVIVRALPKESMDWWM", "length": 326, "header": "sp|Q32PG9-1|FXL12_BOVIN Isoform 1 of F-box/LRR-repeat protein 12 OS=Bos taurus OX=9913 GN=FBXL12 PE=2 SV=1 CANONICAL=Q32PG9-1" }, "locus": { "chromosome": "7", "start_pos": 14415119, "end_pos": 14409237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035207.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035207.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035085.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035085.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617304", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617304", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S3G4-1", "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "FBXL12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRVGGMMATFADLPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTHMEVPTLGIKSELQLLAYITTTTTRDPSHVCDLHHSSRQHQILDPVSGARDRTHILMDTNQMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVANLSMVPITSLPSTLRTLELHSCEISMAWLLKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDMGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLLGPLITPEMPTPAEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM", "length": 393 }, "evidence": [ { "id": "Q32PG9", "url": "https://omabrowser.org/oma/group/Q32PG9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7FJ48-1", "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "Fbxl12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATLFDLPDLVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDSSLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVGGLSAQGLVFLEGMPVLESLCFQGPLITPEMPTPAQIVSSCLTMPKLRVLEVQGLGWEGQEAEKVLCKGLPHCLVIVRACPKESMDWWM", "length": 326 }, "evidence": [ { "id": "Q32PG9", "url": "https://omabrowser.org/oma/group/Q32PG9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H6F3-1", "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "Fbxl12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATLFDLPDLVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVGGLSAQGLVFLEGMPALESLCLQGPLITPEMPTPAQIVTSCLTMPKLRVLEVQGLGWEGQEAEKVLCKGLPHCMVIVRACPKESMDWWM", "length": 326 }, "evidence": [ { "id": "Q32PG9", "url": "https://omabrowser.org/oma/group/Q32PG9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9EPX5-1", "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "Fbxl12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLFDLPDLVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLYSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVGGLSAQGLVFLEGMPVLESLCFQGPLITPDMPTPTQIVSSCLTMPKLRVLEVQGLGWEGQEAEKILCKGLPHCIVIVRACPKESMDWWM", "length": 326 }, "evidence": [ { "id": "Q32PG9", "url": "https://omabrowser.org/oma/group/Q32PG9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NXK8-1", "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "FBXL12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM", "length": 326 }, "evidence": [ { "id": "Q32PG9", "url": "https://omabrowser.org/oma/group/Q32PG9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q32PG9", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PG9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PG9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PG9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG9" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 47, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PH1-1", "uniprot_ac": "Q32PH1", "uniprot_id": "CDCA7_BOVIN", "mass": { "chemical_mass": 42763.0, "monoisotopic_mass": 42763.0 }, "refseq": { "ac": "NP_001032565", "name": "cell division cycle-associated protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032565" }, "gene_names": [ { "name": "CDCA7", "type": "recommended", "evidence": [ { "id": "Q32PH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ] }, { "name": "CDCA7", "type": "synonym", "evidence": [ { "id": "NP_001032565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032565" } ] } ], "protein_names": [ { "name": "Cell division cycle-associated protein 7", "type": "recommended", "evidence": [ { "id": "Q32PH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH1/entry#names_and_taxonomy" } ] }, { "name": "cell division cycle-associated protein 7", "type": "synonym", "evidence": [ { "id": "NP_001032565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032565" } ] } ], "function": [ { "annotation": "Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator.", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1#function" }, { "database": "UniProtKB", "id": "Q9BWT1", "url": "https://www.uniprot.org/uniprotkb/Q9BWT1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDCA7", "url": "https://www.uniprot.org/uniprotkb/Q32PH1", "locus": { "chromosome": "2", "start_pos": 23340522, "end_pos": 23377081, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003458", "url": "https://www.ensembl.org/id/ENSBTAG00000003458" } ] } } ], "crossref": [ { "id": "Q32PH1", "url": "https://alphafold.ebi.ac.uk/entry/Q32PH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003458", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003458", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614893", "url": "https://www.ncbi.nlm.nih.gov/gene/614893", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614893", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614893", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTNVREK", "url": "https://omabrowser.org/oma/group/CTNVREK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PH1", "url": "https://www.orthodb.org/?gene=Q32PH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31169:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31169:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10497", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10497", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032565", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PH1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDARRARQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 374, "header": "sp|Q32PH1-1|CDCA7_BOVIN Isoform 1 of Cell division cycle-associated protein 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=2 SV=1 CANONICAL=Q32PH1-1" }, "isoforms": [ { "isoform_ac": "Q32PH1-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1/entry#Q32PH1-1", "sequence": { "sequence": "MDARRARQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 374, "header": "sp|Q32PH1-1|CDCA7_BOVIN Isoform 1 of Cell division cycle-associated protein 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=2 SV=1 CANONICAL=Q32PH1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "site_lbl": "Ser142" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "site_lbl": "Thr163" }, { "start_pos": 190, "end_pos": 190, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "site_lbl": "Ser190" }, { "start_pos": 196, "end_pos": 196, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "site_lbl": "Thr196" }, { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "site_lbl": "Ser217" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614893", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614893", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32PH1", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PH1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 374, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PH1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PH1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH1" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 160, "end_pos": 176, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 142, 163, 190, 196, 217 ], "sequon_annotation_sites": [ { "start_pos": 258, "end_pos": 260 }, { "start_pos": 266, "end_pos": 268 }, { "start_pos": 331, "end_pos": 333 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PH2-1", "uniprot_ac": "Q32PH2", "uniprot_id": "TM143_BOVIN", "mass": { "chemical_mass": 51449.0, "monoisotopic_mass": 51449.0 }, "refseq": { "ac": "NP_001032524", "name": "transmembrane protein 143", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032524" }, "gene_names": [ { "name": "TMEM143", "type": "recommended", "evidence": [ { "id": "Q32PH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ] }, { "name": "TMEM143", "type": "synonym", "evidence": [ { "id": "NP_001032524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032524" } ] } ], "protein_names": [ { "name": "Transmembrane protein 143", "type": "recommended", "evidence": [ { "id": "Q32PH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 143", "type": "synonym", "evidence": [ { "id": "NP_001032524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032524" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM143", "url": "https://www.uniprot.org/uniprotkb/Q32PH2", "locus": { "chromosome": "18", "start_pos": 55044414, "end_pos": 55064614, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007107", "url": "https://www.ensembl.org/id/ENSBTAG00000007107" } ] } } ], "crossref": [ { "id": "Q32PH2", "url": "https://alphafold.ebi.ac.uk/entry/Q32PH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007107", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007107", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505862", "url": "https://www.ncbi.nlm.nih.gov/gene/505862", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505862", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505862", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERFIPFR", "url": "https://omabrowser.org/oma/group/ERFIPFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PH2", "url": "https://www.orthodb.org/?gene=Q32PH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16095", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16095", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16095:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16095:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12576", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12576", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNW2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PH2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PH2-2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQEFHSTPAEKAALEEFTAHVDFCTLFHYHHVLTQLQALYDPINPDRETLDQPSLTDPQRLSNEKEVLQALEPLLAQANFSPLTEDTLAYALVVHHPQDEVQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 457, "header": "sp|Q32PH2-1|TM143_BOVIN Isoform 1 of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=2 SV=1 CANONICAL=Q32PH2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MNW2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#A0A3Q1MNW2-1", "sequence": { "sequence": "MTVERCLRLRGKGLAMLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 372, "header": "tr|A0A3Q1MNW2-1|A0A3Q1MNW2_BOVIN Computationally mapped isoform of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=4 SV=3 CANONICAL=Q32PH2-1" }, "locus": { "chromosome": "18", "start_pos": 55064614, "end_pos": 55045240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073037.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073037.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071321.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071321.3" } ] } }, { "isoform_ac": "A0AAA9TX08-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#A0AAA9TX08-1", "sequence": { "sequence": "MTVERCLRLRGKGLAMLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQALYDPINPDRETLDQPSLTDPQRLSNEKEVLQALEPLLAQANFSPLTEDTLAYALVVHHPQDEVQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 437, "header": "tr|A0AAA9TX08-1|A0AAA9TX08_BOVIN Computationally mapped isoform of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=4 SV=1 CANONICAL=Q32PH2-1" }, "locus": { "chromosome": "18", "start_pos": 55064614, "end_pos": 55045240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129787.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129787.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103175.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103175.1" } ] } }, { "isoform_ac": "A0AAF6YQH9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#A0AAF6YQH9-1", "sequence": { "sequence": "MTVERCLRLRGKGLAMLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQEFHSTPAEKAALEEFTAHVDFCTLFHYHHVLTQLQALYDPINPDRETLDQPSLTDPQRLSNEKEVLQALEPLLAQANFSPLTEDTLAYALVVHHPQDEVQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 472, "header": "tr|A0AAF6YQH9-1|A0AAF6YQH9_BOVIN Computationally mapped isoform of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=4 SV=1 CANONICAL=Q32PH2-1" }, "locus": { "chromosome": "18", "start_pos": 55064614, "end_pos": 55045240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009350.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009350.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009350.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009350.7" } ] } }, { "isoform_ac": "Q32PH2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#Q32PH2-1", "sequence": { "sequence": "MLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQEFHSTPAEKAALEEFTAHVDFCTLFHYHHVLTQLQALYDPINPDRETLDQPSLTDPQRLSNEKEVLQALEPLLAQANFSPLTEDTLAYALVVHHPQDEVQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 457, "header": "sp|Q32PH2-1|TM143_BOVIN Isoform 1 of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=2 SV=1 CANONICAL=Q32PH2-1" }, "locus": {} }, { "isoform_ac": "Q32PH2-2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2/entry#Q32PH2-2", "sequence": { "sequence": "MLHVTRGVWGSIVRVWPLLPSFLGHSRALSSLEAKMGEYRKMWNPTEPRDWAQQYRERHIPFSKEQLLRLLIQEFHSTPAEKAALEEFTAHVDFCTLFHYHHVLTQLQALYDPINPDRETLDQPSLTDPQRLSNEKEVLQALEPLLAQANFSPLTEDTLAYALVVHHPQDEVQVTINLDQYIYMHFWALGQRVGKMPRKSSVGSKRFFFKSPPAERRYFKRVILAARTKKGHLVLKSFKDTPLEGLEQLLPELKVRTSTLQRAILNVTLIVSGVVFFVNVGMVVLSDLKMATSLLLLLFAAFMGLRAAKMFGHRRSAQALELAHMLYYRSTSNNAELLSALVLRAQDEHTKETLLAHSFLARRPGGAKGPPEAETSQWLQSEVENWLLAQSGCDVAFNGKRALAHLQALPPTVGMYPPPGLPKLDLLATLSSPKSAPSDDNSLEKPLGPAQPSHLVGN", "length": 458, "header": "sp|Q32PH2-2|TM143_BOVIN Isoform 2 of Transmembrane protein 143 OS=Bos taurus OX=9913 GN=TMEM143 PE=2 SV=1 CANONICAL=Q32PH2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 411, "start_aa": "Thr", "end_pos": 411, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr411", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 316, "end_pos": 316, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ], "site_lbl": "Ser316" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505862", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505862", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K513-1", "protein_name": "Transmembrane protein 143", "gene_name": "Tmem143", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFRLWEKGQAMLHVTWGSRVRVWSLVPALLGTPRALSSLENRMGAYRKMWNPKEPCNWAQQYRERFIPFSREQLLRLLIQALYDPINPDRETLDQPSLTDPERLSSEKEVLQALKPLLAQANFSPLSEDALAYALVVHHPQDEVQVTINLDQYIYIQFWALGQRVGQMPHKSSVGSKRGFFRKLPPVERRYFKRVVLAARTKGGHLVLKSFKDTPLEGLEQLLPELKVRTPMMQRALLNLMLVVSGVVFFVNVGMVILSDLKMATSLLLLLFAAFMGIRASKVFGQRRSAQALELAHMLYYRSTSNNSELLSALALRAQEEHIKEALLAHSFLGRQPGGPQGTPEETSRWLQSEVESWLLAQSGCDVTFNGPRALAHLQALTPSFGLFPPPELPQLDPLVLGTPEAPQAALGSSYPSP", "length": 418 }, "evidence": [ { "id": "Q32PH2", "url": "https://omabrowser.org/oma/group/Q32PH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VD26-1", "protein_name": "Transmembrane protein 143", "gene_name": "Tmem143", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTVARWLRLWERGQAMLHVTWGSKVRLWSLVPALLGTPRALSSLENRMGVYRKMWNPKEPCDWAQQYRERFIPFSKEQLLRLLIQEFHSSPAERAALEAFSAHVDFCTLFHYHQLLARLQALYDPINPDRETLDQPSLTDPERLSSEKDVLQALRPLLAQANFSPLSEDALAYALVVHHPQDEVQVTINLDQYIYIQFWALGQRVGQMPHKSSVGSKRGFFRKLPPVERRYFKRVVLAARTKGGHLVLKSFKDTPLEGLEQLLPELKVRTPVLQRALLNLMLVVSGVMIFVNVGMVILSDLKMATSLLLLLFAAFMGVKASKVFGQRRSAQALELAHVLYYRSTSNNSELLSALALRAQEEHIKEALLAHSFLARRPGGSQGKPEETSRWLQSEVESWLLAQSGCDVTFNGPRALAHLQALTPSLGLFPLPELPQLDPMVLGTPEATQAALGSSYPSP", "length": 458 }, "evidence": [ { "id": "Q32PH2", "url": "https://omabrowser.org/oma/group/Q32PH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96AN5-1", "protein_name": "Transmembrane protein 143", "gene_name": "TMEM143", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVELWLRLRGKGLAMLHVTRGVWGSRVRVWPLLPALLGPPRALSSLAAKMGEYRKMWNPREPRDWAQQYRERFIPFSKEQLLRLLIQEFHSSPAEKAALEAFSAHVDFCTLFHYHQILARLQALYDPINPDRETLDQPSLTDPQRLSNEQEVLRALEPLLAQANFSPLSEDTLAYALVVHHPQDEVQVTVNLDQYVYIHFWALGQRVGQMPLKSSVGSRRGFFTKLPPAERRYFKRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTLQRALLNLMLVVSGVAIFVNVGMVVLTDLKVATSLLLLLFAIFMGLRASKMFGQRRSAQALELAHMLYYRSTSNNSELLSALALRAQDEHTKEALLAHSFLARRPGGTQGSPEETSRWLRSEVENWLLAKSGCEVTFNGTRALAHLQALTPSMGLYPPPGFPKLDPVAPITSEPPQATPSSNIS", "length": 459 }, "evidence": [ { "id": "Q32PH2", "url": "https://omabrowser.org/oma/group/Q32PH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32PH2", "url": "https://www.uniprot.org/uniprotkb/Q32PH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PH2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 457, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PH2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PH2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 411 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 316 ], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 266, "end_pos": 268 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3C2I0-1", "uniprot_ac": "Q3C2I0", "uniprot_id": "B2LA1_BOVIN", "mass": { "chemical_mass": 20045.0, "monoisotopic_mass": 20045.0 }, "refseq": { "ac": "NP_001032177", "name": "bcl-2-related protein A1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" }, "gene_names": [ { "name": "BCL2A1", "type": "recommended", "evidence": [ { "id": "Q3C2I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ] }, { "name": "BCL2A1", "type": "synonym", "evidence": [ { "id": "NP_001032177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" } ] } ], "protein_names": [ { "name": "Bcl-2-related protein A1", "type": "recommended", "evidence": [ { "id": "Q3C2I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0/entry#names_and_taxonomy" } ] }, { "name": "B-cell leukemia/lymphoma 2 related protein A1", "type": "synonym", "evidence": [ { "id": "NP_001032177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" } ] }, { "name": "bcl-2-related protein A1", "type": "synonym", "evidence": [ { "id": "NP_001032177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" } ] } ], "function": [ { "annotation": "A high-level expression of BCL2A1 in the conceptus at Day 21 of gestation, and it was expressed and increased in the extraembryonic membrane, cotyledon, and intercotyledon from implantation to term.", "evidence": [ { "database": "RefSeq", "id": "NP_001032177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" }, { "database": "PubMed", "id": "16221993", "url": "https://glygen.org/publication/PubMed/16221993" } ] }, { "annotation": "Regulation of A1 and Bak contribute to mitochondrial membrane stability, reduced caspase-9 activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids", "evidence": [ { "database": "RefSeq", "id": "NP_001032177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" }, { "database": "PubMed", "id": "16675521", "url": "https://glygen.org/publication/PubMed/16675521" } ] }, { "annotation": "Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0#function" }, { "database": "UniProtKB", "id": "Q07440", "url": "https://www.uniprot.org/uniprotkb/Q07440#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL2A1", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0", "locus": { "chromosome": "21", "start_pos": 25981599, "end_pos": 25991429, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000735", "url": "https://www.ensembl.org/id/ENSBTAG00000000735" } ] } } ], "crossref": [ { "id": "Q3C2I0", "url": "https://alphafold.ebi.ac.uk/entry/Q3C2I0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000735", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000735", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282151", "url": "https://www.ncbi.nlm.nih.gov/gene/282151", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282151", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282151", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SKITAMF", "url": "https://omabrowser.org/oma/group/SKITAMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3C2I0", "url": "https://www.orthodb.org/?gene=Q3C2I0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11256:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3C2I0-1", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDTEFGYVHGLAEDYLKYVLQIQQPGSKPSKTSRVLQDVASSVQDEVERTLKQCLDKFDVVSVDTARTIFNQVMEKEFEDGIVNWGRIVTIFAFEGILTKKLLGKCIASDMDMCKDISFFVAEFITENTGEWIKQNGGWENGFVKKFETKSGWLTFLEVTGKICETLCRLKQYY", "length": 175, "header": "sp|Q3C2I0-1|B2LA1_BOVIN Isoform 1 of Bcl-2-related protein A1 OS=Bos taurus OX=9913 GN=BCL2A1 PE=2 SV=1 CANONICAL=Q3C2I0-1" }, "isoforms": [ { "isoform_ac": "Q3C2I0-1", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0/entry#Q3C2I0-1", "sequence": { "sequence": "MTDTEFGYVHGLAEDYLKYVLQIQQPGSKPSKTSRVLQDVASSVQDEVERTLKQCLDKFDVVSVDTARTIFNQVMEKEFEDGIVNWGRIVTIFAFEGILTKKLLGKCIASDMDMCKDISFFVAEFITENTGEWIKQNGGWENGFVKKFETKSGWLTFLEVTGKICETLCRLKQYY", "length": 175, "header": "sp|Q3C2I0-1|B2LA1_BOVIN Isoform 1 of Bcl-2-related protein A1 OS=Bos taurus OX=9913 GN=BCL2A1 PE=2 SV=1 CANONICAL=Q3C2I0-1" }, "locus": { "chromosome": "21", "start_pos": 25991242, "end_pos": 25981774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000977.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000977.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000977.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000977.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta.", "journal": "Biol. Reprod.", "date": "2006", "authors": "Ushizawa Koichi, Takahashi Toru, Kaneyama Kanako, Hosoe Misa, Hashizume Kazuyoshi", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" }, { "database": "RefSeq", "id": "NP_001032177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" } ], "reference": [ { "type": "PubMed", "id": "16221993", "url": "https://glygen.org/publication/PubMed/16221993" } ] }, { "title": "Glucocorticoid modulation of Bcl-2 family members A1 and Bak during delayed spontaneous apoptosis of bovine blood neutrophils.", "journal": "Endocrinology", "date": "2006-08", "authors": "Madsen-Bouterse Sally A, Rosa Guilherme J M, Burton Jeanne L", "evidence": [ { "database": "RefSeq", "id": "NP_001032177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032177" } ], "reference": [ { "type": "PubMed", "id": "16675521", "url": "https://glygen.org/publication/PubMed/16675521" } ] } ], "pathway": [ { "id": "bta:282151", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282151", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3V977-1", "protein_name": "Bcl-2-related protein A1", "gene_name": "Bcl2a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTDCEFMYIHSLAENYLQYVLQVPAFESAPSKTSRVLQRVAFSVQKEVEKNLKPYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVDTYKQVSSFVAEFIMNNTGEWIQQNGGWEDGFTKKFEPKSGWLTFLQMTGKIWEMLFLLKQHY", "length": 175 }, "evidence": [ { "id": "Q3C2I0", "url": "https://omabrowser.org/oma/group/Q3C2I0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O55179-1", "protein_name": "Bcl-2-related protein A1", "gene_name": "Bcl2a1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEYEFMYIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVGAYKQVSSFVAEFIMNNTGEWIRRNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK", "length": 172 }, "evidence": [ { "id": "Q3C2I0", "url": "https://omabrowser.org/oma/group/Q3C2I0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16548-1", "protein_name": "Bcl-2-related protein A1", "gene_name": "BCL2A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC", "length": 175 }, "evidence": [ { "id": "Q3C2I0", "url": "https://omabrowser.org/oma/group/Q3C2I0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "release of cytochrome c from mitochondria", "id": "GO:0001836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001836", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "mitochondrial fusion", "id": "GO:0008053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:0097192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097192", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "channel activity", "id": "GO:0015267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015267", "evidence": [ { "database": "UniProtKB", "id": "Q3C2I0", "url": "https://www.uniprot.org/uniprotkb/Q3C2I0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3C2I0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 175, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3C2I0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3C2I0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHG6-1", "uniprot_ac": "Q3MHG6", "uniprot_id": "GTPBA_BOVIN", "mass": { "chemical_mass": 42932.0, "monoisotopic_mass": 42932.0 }, "refseq": { "ac": "NP_001073783", "name": "GTP-binding protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073783" }, "gene_names": [ { "name": "GTPBP10", "type": "recommended", "evidence": [ { "id": "Q3MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ] }, { "name": "GTPBP10", "type": "synonym", "evidence": [ { "id": "NP_001073783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073783" } ] } ], "protein_names": [ { "name": "GTP-binding protein 10", "type": "recommended", "evidence": [ { "id": "Q3MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6/entry#names_and_taxonomy" } ] }, { "name": "GTP-binding protein 10 (putative)", "type": "synonym", "evidence": [ { "id": "NP_001073783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073783" } ] }, { "name": "GTP-binding protein 10", "type": "synonym", "evidence": [ { "id": "NP_001073783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073783" } ] } ], "function": [ { "annotation": "May be involved in the ribosome maturation process.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTPBP10", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6", "locus": { "chromosome": "4", "start_pos": 74559891, "end_pos": 74533033, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032166", "url": "https://www.ensembl.org/id/ENSBTAG00000032166" } ] } } ], "crossref": [ { "id": "Q3MHG6", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01898", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01898", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613957", "url": "https://www.ncbi.nlm.nih.gov/gene/613957", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613957", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613957", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHG6", "url": "https://www.orthodb.org/?gene=Q3MHG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11702", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11702", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11702:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11702:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073783", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHG6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRCSCVLFRKYGNFIDNLRLFTKGGSGGMGYPRLGGEGGKGGDVWVVAHNRMTLKQLKDKYPQKRFVAGEGANSRVSALKGSKGKDCEIPVPVGVSVTDENGKIIGELNKEKDRLLVAEGGLGGKLLTNFLPLKGQKRVIHLDLKLIADIGLVGFPNAGKSSLLSKISHAKPAIADYAFTTIKPELGKIMYSDFKQISVADLPGLIEGAHMNKGMGHKFLKHIERTKQLLFVVDISGFQLSSQTHYRTAFETIILLSKELELYKEELHTKPALLAVNKMDLPDAQGKFHVLMNQLQNPKEFFHLFEKNMIPERTVEFQHIIPISAITGEGIDELKNCIRKSLDEHTNQENDAYHKKQLLNLHISNTVSYSEPPSKTAVSSPRMDIT", "length": 387, "header": "sp|Q3MHG6-1|GTPBA_BOVIN Isoform 1 of GTP-binding protein 10 OS=Bos taurus OX=9913 GN=GTPBP10 PE=2 SV=1 CANONICAL=Q3MHG6-1" }, "isoforms": [ { "isoform_ac": "Q3MHG6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6/entry#Q3MHG6-1", "sequence": { "sequence": "MVRCSCVLFRKYGNFIDNLRLFTKGGSGGMGYPRLGGEGGKGGDVWVVAHNRMTLKQLKDKYPQKRFVAGEGANSRVSALKGSKGKDCEIPVPVGVSVTDENGKIIGELNKEKDRLLVAEGGLGGKLLTNFLPLKGQKRVIHLDLKLIADIGLVGFPNAGKSSLLSKISHAKPAIADYAFTTIKPELGKIMYSDFKQISVADLPGLIEGAHMNKGMGHKFLKHIERTKQLLFVVDISGFQLSSQTHYRTAFETIILLSKELELYKEELHTKPALLAVNKMDLPDAQGKFHVLMNQLQNPKEFFHLFEKNMIPERTVEFQHIIPISAITGEGIDELKNCIRKSLDEHTNQENDAYHKKQLLNLHISNTVSYSEPPSKTAVSSPRMDIT", "length": 387, "header": "sp|Q3MHG6-1|GTPBA_BOVIN Isoform 1 of GTP-binding protein 10 OS=Bos taurus OX=9913 GN=GTPBP10 PE=2 SV=1 CANONICAL=Q3MHG6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613957", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613957", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG6", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHG6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 387, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHG6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHG6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" }, { "id": "PRU01047", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01047" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OBG-type G", "eco_id": "ECO_0000255", "start_pos": 149, "end_pos": 344, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG6" }, { "id": "PRU01231", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01231" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Obg", "eco_id": "ECO_0000255", "start_pos": 13, "end_pos": 148, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHH2-1", "uniprot_ac": "Q3MHH2", "uniprot_id": "NOL11_BOVIN", "mass": { "chemical_mass": 80290.0, "monoisotopic_mass": 80290.0 }, "refseq": { "ac": "NP_001029697", "name": "nucleolar protein 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029697" }, "gene_names": [ { "name": "NOL11", "type": "recommended", "evidence": [ { "id": "Q3MHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ] }, { "name": "NOL11", "type": "synonym", "evidence": [ { "id": "NP_001029697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029697" } ] } ], "protein_names": [ { "name": "Nucleolar protein 11", "type": "recommended", "evidence": [ { "id": "Q3MHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2/entry#names_and_taxonomy" } ] }, { "name": "nucleolar protein 11", "type": "synonym", "evidence": [ { "id": "NP_001029697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029697" } ] } ], "function": [ { "annotation": "Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2#function" }, { "database": "UniProtKB", "id": "Q9H8H0", "url": "https://www.uniprot.org/uniprotkb/Q9H8H0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOL11", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2", "locus": { "chromosome": "19", "start_pos": 49176026, "end_pos": 49194712, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015951", "url": "https://www.ensembl.org/id/ENSBTAG00000015951" } ] } } ], "crossref": [ { "id": "Q3MHH2", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015951", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015951", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517743", "url": "https://www.ncbi.nlm.nih.gov/gene/517743", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517743", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517743", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGTTGQC", "url": "https://omabrowser.org/oma/group/QGTTGQC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHH2", "url": "https://www.orthodb.org/?gene=Q3MHH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15633", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15633", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15633:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15633:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20998", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20998", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029697", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLEEGFALTAVPLGSGPDGPLGVEQSGKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYIVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRIHSIQGTEPLVLFKEGAVRGLEALLAEPQQKIETVISDEEVIKWTKFFMVFRHPVLIFITEKHGNYFVYVQKFNSRILSKYTLLLGQEEKCVIQSFSTSVGRKFISLMSLSSDGCVYETLIPIHPSEPEKNQRLVQSQLLKSVVSGSARNGVALAILDQDHIAVLGAPLPASKECLSVWNTKFQTLQTSKELPQGTSGQLWYYGENLFMLHGKFLTVVPFKCEVSSLAGALGKLKHSQDPGIHATPHFVNWETSQGCGLGSQNSEQSKRILRRRKVEVSVQPEVPASTQLLATIQKDSEKHIEVELRKFLATKRTPDFHTIIGDVIIGLLGRCKAEPSFYPCNCLMQLVQTHVLSYSLCPGLMEFALEKTDVQILQLCLQQFPDIPESVTCACLKVFLSIGDDTLQDTDINMESVSDYMDPVQDGEMEEQTAFLQNGFSPEEDNCDSCAQKLKEKPQAAADESTSCPVTPKRAALLNAVLHSAYSETFLLPHLKDIPAQHSTLFLQYLYFLYLKCSENATMTLPGTHPPTLSQIMDWICLLLDANFTVVVMIPEAKRLLLSLYKFVKSQISICSELNKIEVSFRELQKLNQEKNNRELYSIEVLELF", "length": 718, "header": "sp|Q3MHH2-1|NOL11_BOVIN Isoform 1 of Nucleolar protein 11 OS=Bos taurus OX=9913 GN=NOL11 PE=2 SV=1 CANONICAL=Q3MHH2-1" }, "isoforms": [ { "isoform_ac": "Q3MHH2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2/entry#Q3MHH2-1", "sequence": { "sequence": "MADLEEGFALTAVPLGSGPDGPLGVEQSGKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYIVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRIHSIQGTEPLVLFKEGAVRGLEALLAEPQQKIETVISDEEVIKWTKFFMVFRHPVLIFITEKHGNYFVYVQKFNSRILSKYTLLLGQEEKCVIQSFSTSVGRKFISLMSLSSDGCVYETLIPIHPSEPEKNQRLVQSQLLKSVVSGSARNGVALAILDQDHIAVLGAPLPASKECLSVWNTKFQTLQTSKELPQGTSGQLWYYGENLFMLHGKFLTVVPFKCEVSSLAGALGKLKHSQDPGIHATPHFVNWETSQGCGLGSQNSEQSKRILRRRKVEVSVQPEVPASTQLLATIQKDSEKHIEVELRKFLATKRTPDFHTIIGDVIIGLLGRCKAEPSFYPCNCLMQLVQTHVLSYSLCPGLMEFALEKTDVQILQLCLQQFPDIPESVTCACLKVFLSIGDDTLQDTDINMESVSDYMDPVQDGEMEEQTAFLQNGFSPEEDNCDSCAQKLKEKPQAAADESTSCPVTPKRAALLNAVLHSAYSETFLLPHLKDIPAQHSTLFLQYLYFLYLKCSENATMTLPGTHPPTLSQIMDWICLLLDANFTVVVMIPEAKRLLLSLYKFVKSQISICSELNKIEVSFRELQKLNQEKNNRELYSIEVLELF", "length": 718, "header": "sp|Q3MHH2-1|NOL11_BOVIN Isoform 1 of Nucleolar protein 11 OS=Bos taurus OX=9913 GN=NOL11 PE=2 SV=1 CANONICAL=Q3MHH2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517743", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517743", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K1A9-1", "protein_name": "Nucleolar protein 11", "gene_name": "Nol11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALEEEFTLSTGVLGAGPEGFLGVEPSDKADQFLVTDRGRTVVLYKVSDQKPLGSWSVKQGQTITCPAVCNFQTGEYIMVHDHKVLRIWNNEDVNLDKVFKATLSAEVHRIHSVQRTEPLVLFRRGAARGLEALLAEPQQNIEAVIPDEEVIEWSEVFMLFKQPVLIFITENHGSYVAYVQLCKSHSLSKYILLLGKEEKSAKPNFTARVDGKFISLVSLGSDGCVYETLVPIYSSDTENNQRLVRALMLKTVVSGSARNGSALTILDQDHIAVLGPPLPASKECLSIWNIKFQTLQTSKELPQGTSGQLWYHGEILFMRHGKSLTVIPYKCEASSLASALGKLKHTQESGSHSVPHFVNWETCSEYELGSYSAKQTRTLRKKTETNLHPEVPGVKELLSIIKKDSEKHIEVELRKFLAKSTPDFHTIIGDIVSGLLGRCKVEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALEHTDVQMLQLCLQQFPDIPESTTCACLKLFLSIGDDCLRDSNVSMESVFDYGDTTQDEKKEMEEQTEIVQNGFGPEDGGCSKDSQQLNKKPGDTAQEPISFPVTLCPVAPKRAALLRNAVLHSAYSEPFLLPHLKDIPAKHITLFLQYLYFLYLKCTGSATMTLPGVSPPTVSQIMDWICLLLDANFTVVLMIPEAKRLLLNLYNFVKSQISIYSELNKIEVSFRELQRLNQEKSSRGLYSIEVLELF", "length": 723 }, "evidence": [ { "id": "Q3MHH2", "url": "https://omabrowser.org/oma/group/Q3MHH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AN63-1", "protein_name": "Nucleolar protein 11", "gene_name": "NOL11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALCEAFTLCGLGPAGGVGLGSGLLALEPGADPDHVLLTDRGRTTTLFKVSDQKPLGCWSVKHGQIITCPVVCNFETHEYIAVHDNKVLRIWKDEDVNLDKVFKATLSAEVYRIHSLPHAEPLVLFKGGGVRTLDVLLEAPQQEIENVISDEVIKWSEAFLESRQPVLIFVTEKDGDFFVYVQKPKMRSLHKYKLEQQELCNPLSFTAYIKKQIITLLCLYSSDSVYKVLIPLQQSSEEEEQTLSKSLLLNLSISGSVLKGTSFVVLDKDHVAVLGSLAASGEESKECLTIWNTKFQTLQASKELPLGTSGQLWCYGEKFFFTHGKVLTVVIYKCETSSLAAAVGKLKDSQTSDLSSFVNWNTLGDEELLVSLQSQQSVALKSESKMTLRSKKSTVANIQPDTSTVGQFLLSIKDASTAAVEDQLRQLLSKAQMPDFQAAIGCIISALINRCKTDPKFYPRNFLVQMIQKGELSYSLCPDLMAVALEKKDVHLLQICLQRFPDIPEEITYACLKVFLSISDDYLERTDVNLESVISYIDIEPNNKEVKTEVVENGFSTELEEDGCDVTGMKETHMMDSVEFCPVGPQKAALLNAVLHSAYSETFLLPHLKDLPAQQAVLFLRYLHYLYVKCSEKINTTLPGILSPTISQIMDWMCLLLDAHFTVMVMLPEAKGLLSSMHRFVRAQVRLYSELNKIEGSLQELQRIKCQKHSQAYSIEVLELI", "length": 723 }, "evidence": [ { "id": "Q3MHH2", "url": "https://omabrowser.org/oma/group/Q3MHH2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BJW5-1", "protein_name": "Nucleolar protein 11", "gene_name": "Nol11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLEEEFTLSTGVLGAGPEGFLGVEQTDKADQFLVTDSGRTVVLYKVSDQKPLGSWSVKQGQSITCPAVCNFQTGEYIMVHDHKVLRIWNNDDVNVDKVFKATLSAEVHRIHSVQRTEPLVLFRGGAARGLEALLVEPQQNIESVIPDEEVIVWSEVFMLFKQPVLIFITENHGHYYAYVRLCKSHSLSKYTLLLEKEEKSVKPNFTARVDGKFISLVSLSSDGCIYETLIPIYSSDTEQNQRLVRALMLKSVVSGGVRNGVALTILDQDHIAVLGPPLSASKECLSIWNIKFQTLQTSKELPQGTSGQLWYHGEVLFMLHGKSLTVIPYKCEESSLAGALGKLKHTQESGTHSVPHFVNWETCSGYELGSSGAEQSRTLRRKKVETNLQPEVPGFKQLLSIIKKDSEKHIEVELRKFLAKSTPAFHTIIGDLVAGLVGRCKAEPSFYPRNCLTQLIQTHVLSYSLCPDLMEIALEHTDVQMLQLCLQQFPDIPESTTCACLKLFLSVGDDCLRDSNINMESVFDYSDSTQDEKKEMEEQIEIVQNGFGPEDGNCSEDSQQLNDKPADTAHEPGSFPVTSCPVAPKRAALLNAVLHSAYSEPFLLPHLKDIPAKHVTLFLQYLYFLYLKCTGSATMTLPGVNPPTVSQIMDWICLLLDANFTVLLMIPEAKRLLLILYNFVKSQISIYSELNKIAVSFRELQRLNREKSSRGLYSIEVLELF", "length": 723 }, "evidence": [ { "id": "Q3MHH2", "url": "https://omabrowser.org/oma/group/Q3MHH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H8H0-1", "protein_name": "Nucleolar protein 11", "gene_name": "NOL11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF", "length": 719 }, "evidence": [ { "id": "Q3MHH2", "url": "https://omabrowser.org/oma/group/Q3MHH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VW10-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG9300", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKFLSYYNLFPIPDPKEFLGLAADRENGNVVTTLARNVVVVLNISTQKQLLSWSLPEKLSSKVIYDPSSQKYVGVFGNHALRLWDVDTSDVSKCKKLKFQKSIAHVVATEQEALILYSDGECQTLSQALASRKDQKEDTAEQLALAASKVISKPTVHALAQGQQVLTYFEETKATGEMQLIRLSLDTADRRKYLIKREEVRLTGYAVVEGDADPQLLTIWSDKRIFMLNLAEATSERSPGQFVSMLAELNVESKLSVHGVSRNFAAIYGANYGQEGASLLVYNTQFKVVNAKQYFKVYLDFSRLWAGNEHILLAMGHNIAAVRYRMNREVLVDMLGSQFSDTHLSPIELDHINEEEYLESLIKFDGSTKPLNYRAVKSQLNKQMPNLDYQKADGRELAYDPPEVVDQEIDEIIKQHVHGEATICENGLEDVSVTLMTNFFDKGPNNTAVQALVRQLERSGAGEEEIIERILTLFIKTDNTEHVLMCLRRYSNISERMLAWSLRYALDKCKPRHAINGDSNAVPTAKSYSNKELLNAVLACRFDATGIEEHLRYRLELSHVQHLMSHLFDLVNDPNVQLEERPSLNCSPIQTEVQAIQWFGCILTSHFTLLIISKDEALLETLSEWATFLSFYEESLFDLANLLPLLTNIVEKRQVKPMYSTNWYGIEEVVLY", "length": 673 }, "evidence": [ { "id": "Q3MHH2", "url": "https://omabrowser.org/oma/group/Q3MHH2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "pmid": "" }, { "name": "t-UTP complex", "id": "GO:0034455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034455", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "pmid": "" }, { "name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901838", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA", "id": "GO:0030490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030490", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH2", "url": "https://www.uniprot.org/uniprotkb/Q3MHH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHH2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 718, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHH2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHH2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 629, "end_pos": 631 }, { "start_pos": 656, "end_pos": 658 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHH3-1", "uniprot_ac": "Q3MHH3", "uniprot_id": "S1PBP_BOVIN", "mass": { "chemical_mass": 47176.0, "monoisotopic_mass": 47176.0 }, "refseq": { "ac": "NP_001029859", "name": "S100P-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029859" }, "gene_names": [ { "name": "S100PBP", "type": "recommended", "evidence": [ { "id": "Q3MHH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ] }, { "name": "S100PBP", "type": "synonym", "evidence": [ { "id": "NP_001029859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029859" } ] } ], "protein_names": [ { "name": "S100P-binding protein", "type": "recommended", "evidence": [ { "id": "Q3MHH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3/entry#names_and_taxonomy" } ] }, { "name": "S100P-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029859" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100PBP", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3", "locus": { "chromosome": "2", "start_pos": 120817208, "end_pos": 120848832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018067", "url": "https://www.ensembl.org/id/ENSBTAG00000018067" } ] } } ], "crossref": [ { "id": "Q3MHH3", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018067", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018067", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539983", "url": "https://www.ncbi.nlm.nih.gov/gene/539983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539983", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHMQNSK", "url": "https://omabrowser.org/oma/group/HHMQNSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHH3", "url": "https://www.orthodb.org/?gene=Q3MHH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14455", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14455", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14455:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14455:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15427", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15427", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMCSLVPSEQSSGTSLLPKDNAPFSWSSLDEDELDDSLLELSDGEDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVEKGEKGSQIPLDTPQEKDSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVTVAPFDPTVCDVALDKDKTYVSEVTSRVTEKPSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPSSNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPNTGSSRRNGSYKSSFEMKLPVSSSSSKDVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQVHHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRLPDFPYGPFVSSHQQ", "length": 422, "header": "sp|Q3MHH3-1|S1PBP_BOVIN Isoform 1 of S100P-binding protein OS=Bos taurus OX=9913 GN=S100PBP PE=2 SV=1 CANONICAL=Q3MHH3-1" }, "isoforms": [ { "isoform_ac": "Q3MHH3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3/entry#Q3MHH3-1", "sequence": { "sequence": "MMCSLVPSEQSSGTSLLPKDNAPFSWSSLDEDELDDSLLELSDGEDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVEKGEKGSQIPLDTPQEKDSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVTVAPFDPTVCDVALDKDKTYVSEVTSRVTEKPSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPSSNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPNTGSSRRNGSYKSSFEMKLPVSSSSSKDVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQVHHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRLPDFPYGPFVSSHQQ", "length": 422, "header": "sp|Q3MHH3-1|S1PBP_BOVIN Isoform 1 of S100P-binding protein OS=Bos taurus OX=9913 GN=S100PBP PE=2 SV=1 CANONICAL=Q3MHH3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 132, "start_aa": "Thr", "end_pos": 132, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr132", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 195, "end_pos": 195, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ], "site_lbl": "Ser195" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539983", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539983", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5K1VN55-1", "protein_name": "S100P-binding protein", "gene_name": "S100PBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTCSLVPSEQSSGASLLPKDSAPFSWGSLDEDGLDDSLLELSEGEDDGHFSFTEEEIQELLKDDDLSNEHLSKERGLLNGDNRNVEKGGKGSQILLDTPHEKNSLYNLGPVTETPGLFKLPQLSTSVGHGPTPKPLNRRFALEKNLIKVTVAPFDPRVCDVVLDKDKTDTSKDIEKPSSLGEEMREDGLSPKENTLCTESEGISPSNSAYNGPPFPSSNNNFQQTVSDKNIPDNKKPTPASSQILDHSETPNLGSSWRNRSHKPNLEVKFPVVSSSSNKKDVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTSSPSDLEKQKQSYLRNVIAHIEDPVDSNQGALGELCTLMDQVHHMQNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNMRSHHRFQRLPDFQYSSFVSSHQQ", "length": 419 }, "evidence": [ { "id": "Q3MHH3", "url": "https://omabrowser.org/oma/group/Q3MHH3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZSX9-1", "protein_name": "S100P-binding protein", "gene_name": "S100pbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTCSLLPSEQSSGTSFLPKDNASFSWGSSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDDGGHNEYRARKSQILPHTPQENSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLDKDKIDSSKETEKPASLQEQTREDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSPSNNNIEQTASDKNIPESKKPTPVFSQISNHSEVPNRKNSGSHKSGCEVRIPVVSSSSNRHAFDKDSGEAKGERRLGKVIPVLQTRTRMFSQSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQVHMQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRLPDFSYSPYVSPHPQ", "length": 396 }, "evidence": [ { "id": "Q3MHH3", "url": "https://omabrowser.org/oma/group/Q3MHH3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H934-1", "protein_name": "S100P-binding protein", "gene_name": "S100pbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTCSLLPSEQSSGTSFLPKDNASFSWGSSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDDGGHEYGERKCQILPGTRRENSLYSLGPAAETPGFFKLPQLSTSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLAKDKVDSSKDTENPASLGERIGEDDLHPNESKHCTEPEGVSPDNSARDGPLLSSPSNNNIEQTASDKNVPESKKPTPVFSQISNHSEVPNRGSSWKNSGSHKSGCEVRIPVVSSSSNRHTFDKDSGEVKSERRLGKVIPVLQTRTRMFSQSDLEKQKDIYLSKVIAHIEDPGDSNQGTLGELDALMDQVHMQNPDWQHPSDLTTRNYARFRQKPLQRYSLSQWVDRNKRSHHRFQRLPDFSYSPYVSSHPQ", "length": 399 }, "evidence": [ { "id": "Q3MHH3", "url": "https://omabrowser.org/oma/group/Q3MHH3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96BU1-1", "protein_name": "S100P-binding protein", "gene_name": "S100PBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVTVAPFNPTVCDALLDKDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSCRNGGSHKSSCEMRSLVVSTSSNKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYARRQKHLQRYSLTQWVDRNMRSHHRFQRLPDFSYS", "length": 408 }, "evidence": [ { "id": "Q3MHH3", "url": "https://omabrowser.org/oma/group/Q3MHH3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D5K4-1", "protein_name": "S100P-binding protein", "gene_name": "S100pbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTCSLLPSEQSSGASFLPKSNASFPWGSLDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDDGGHNEYRPRKSQILPDIPQENSLYSLGPAAETPGFLKLPQLSTSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLDKDKIDSSKETENPASLREQTREDDPQPNESKRCTEPEGVSPNTSAWDGPLLSSPSNNNIEQTASDKNIPESKKPTPVFSQISNHSEVPNRKNSGSHKSGCEVRIPVVSSSSNRHAFDKDSGEAKGERRLGKVIPVLQTRTRMFSQSELEKQKDIYLSKVIAHIEDPGDSNQGTLGELDALMDQVHMQHPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRLPDFSYSPYVSSHQQ", "length": 396 }, "evidence": [ { "id": "Q3MHH3", "url": "https://omabrowser.org/oma/group/Q3MHH3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 422, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHH3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 132 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 195 ], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 264, "end_pos": 266 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHI3-1", "uniprot_ac": "Q3MHI3", "uniprot_id": "S2548_BOVIN", "mass": { "chemical_mass": 33445.0, "monoisotopic_mass": 33445.0 }, "refseq": {}, "gene_names": [ { "name": "SLC25A48", "type": "recommended", "evidence": [ { "id": "Q3MHI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ] } ], "protein_names": [ { "name": "Solute carrier family 25 member 48", "type": "recommended", "evidence": [ { "id": "Q3MHI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mitochondrial transporter that mediates choline import across the inner mitochondrial membrane, thereby regulating mitochondrial choline levels and downstream metabolism, including betaine and purine nucleotide synthesis. Plays a key role in mitochondrial respiration, brown fat thermogenesis, and the maintenance of mitochondrial membrane integrity.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3#function" }, { "database": "UniProtKB", "id": "Q8BW66", "url": "https://www.uniprot.org/uniprotkb/Q8BW66#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC25A48", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3", "locus": { "chromosome": "7", "start_pos": 47313101, "end_pos": 47266190, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018287", "url": "https://www.ensembl.org/id/ENSBTAG00000018287" } ] } } ], "crossref": [ { "id": "Q3MHI3", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "515496", "url": "https://www.ncbi.nlm.nih.gov/gene/515496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHI3", "url": "https://www.orthodb.org/?gene=Q3MHI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45624:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45624:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "32751", "url": "https://www.rhea-db.org/rhea/32751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNFQLEDFVAGWIGGAASVIVGHPLDTVKARLQAGSGYGSTLSCIRTVYRRESVFGFFKGMSFPLASIAVYNSVVFGVFSNTQRFLSHHRCQEPEAGPPHVLSDLLLASMVAGVVSVGLGAPVDLIEIRLQMQTQPFQEANLGLKPRVAALGEQPAYQGPVHCFATIVRTEGLAGLYRGASAMLLRDVPGYCLYFIPYVFLSDWITPEACAGPSPCAVWLAGGMAGAISWGTATPMDVVKSRLQADGVYVNKYRGVLDCMSQSYQKEGLKVFFRGITVNAVRGFPMSAAMFLGYELSLQAIRGDHVVTSP", "length": 311, "header": "sp|Q3MHI3-1|S2548_BOVIN Isoform 1 of Solute carrier family 25 member 48 OS=Bos taurus OX=9913 GN=SLC25A48 PE=2 SV=1 CANONICAL=Q3MHI3-1" }, "isoforms": [ { "isoform_ac": "Q3MHI3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3/entry#Q3MHI3-1", "sequence": { "sequence": "MGNFQLEDFVAGWIGGAASVIVGHPLDTVKARLQAGSGYGSTLSCIRTVYRRESVFGFFKGMSFPLASIAVYNSVVFGVFSNTQRFLSHHRCQEPEAGPPHVLSDLLLASMVAGVVSVGLGAPVDLIEIRLQMQTQPFQEANLGLKPRVAALGEQPAYQGPVHCFATIVRTEGLAGLYRGASAMLLRDVPGYCLYFIPYVFLSDWITPEACAGPSPCAVWLAGGMAGAISWGTATPMDVVKSRLQADGVYVNKYRGVLDCMSQSYQKEGLKVFFRGITVNAVRGFPMSAAMFLGYELSLQAIRGDHVVTSP", "length": 311, "header": "sp|Q3MHI3-1|S2548_BOVIN Isoform 1 of Solute carrier family 25 member 48 OS=Bos taurus OX=9913 GN=SLC25A48 PE=2 SV=1 CANONICAL=Q3MHI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515496", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "pmid": "" }, { "name": "choline transmembrane transporter activity", "id": "GO:0015220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015220", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "choline transport", "id": "GO:0015871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015871", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI3", "url": "https://www.uniprot.org/uniprotkb/Q3MHI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32751", "name": "", "equation": "choline(out) = choline(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9XSA7-1" ], "evidence": [ { "id": "32751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHI7-1", "uniprot_ac": "Q3MHI7", "uniprot_id": "RF1M_BOVIN", "mass": { "chemical_mass": 52548.0, "monoisotopic_mass": 52548.0 }, "refseq": { "ac": "NP_001030185", "name": "peptide chain release factor 1, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" }, "gene_names": [ { "name": "MTRF1", "type": "recommended", "evidence": [ { "id": "Q3MHI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ] }, { "name": "MTRF1", "type": "synonym", "evidence": [ { "id": "NP_001030185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" } ] }, { "name": "MtRF-1", "type": "synonym", "evidence": [ { "id": "NP_001030185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" } ] } ], "protein_names": [ { "name": "Peptide chain release factor 1, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3MHI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#names_and_taxonomy" } ] }, { "name": "MRF-1", "type": "synonym", "evidence": [ { "id": "NP_001030185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" }, { "id": "Q3MHI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#names_and_taxonomy" } ] }, { "name": "MtRF-1", "type": "synonym", "evidence": [ { "id": "Q3MHI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial translational release factor 1", "type": "synonym", "evidence": [ { "id": "NP_001030185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" } ] }, { "name": "peptide chain release factor 1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185" } ] } ], "function": [ { "annotation": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA. Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively. Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7#function" }, { "database": "UniProtKB", "id": "O75570", "url": "https://www.uniprot.org/uniprotkb/O75570#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTRF1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7", "locus": { "chromosome": "12", "start_pos": 11422782, "end_pos": 11461232, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012260", "url": "https://www.ensembl.org/id/ENSBTAG00000012260" } ] } } ], "crossref": [ { "id": "Q3MHI7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012260", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012260", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504754", "url": "https://www.ncbi.nlm.nih.gov/gene/504754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504754", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECQQSRS", "url": "https://omabrowser.org/oma/group/ECQQSRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIH9", "url": "https://www.orthodb.org/?gene=A0A452DIH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHI7", "url": "https://www.orthodb.org/?gene=Q3MHI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43804", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43804", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43804:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43804:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIH9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIH9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHI7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRRHLFAWLFRHLSLNGHLQCHVHRHSHQLTQIPLDTRLWVFRRNRNHTVHRLLNKNCSRRYCHQDTSMLWKHKALQKYMEDLNKEYQTLDHCLHHISASEGDRRSLTRRHAELAPLAVIYKEIQEAEQAIEELESMCKSLNKQDEKQLQELALEERQTIAQKINMLYSELFQSLLPKEKYDKNDVILEVTSGRTTGGDICQQFTREIFDMYQNYSSYKHWRFELLNYTPADYGGLHHAAARISGDNVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPHPDEVDVKVDPKDLRIDTFRAKGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQIKNKEIALRVLRARLYQQIIEKDKCQQRSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRNIKEFLCGEKCLDQLIQRLLQSADEEAITEFLDENLKSVK", "length": 447, "header": "sp|Q3MHI7-1|RF1M_BOVIN Isoform 1 of Peptide chain release factor 1, mitochondrial OS=Bos taurus OX=9913 GN=MTRF1 PE=2 SV=1 CANONICAL=Q3MHI7-1" }, "isoforms": [ { "isoform_ac": "A0A452DIH9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#A0A452DIH9-1", "sequence": { "sequence": "MNRRHLFAWLFRHLSLNGHLQCHVHRHSHQLTQIPLDTRLWVFRRNRNHTVHRLLNKNCSRRYCHQDTSMLWKHKALQKYMEDLNKEYQTLDHCLHHISASEGDRRSLTRRHAELAPLAVIYKEIQEAEQAIEELESMCKSLNKQDEKQLQELALEERQTIAQKINMLYSELFQSLLPKEKYDKNDVILEVTSGRTTGGDICQQFTREIFDMYQNYSSYKHWRFELLNYTPADYGGLHHAAARISGDNVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPHPDEVDVKVDPKDLRIDTFRAKGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQIKNKEIALRVLRARLYQQIIEKDKCQQRSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRNIKAERSVA", "length": 416, "header": "tr|A0A452DIH9-1|A0A452DIH9_BOVIN Computationally mapped isoform of Mitochondrial translation release factor 1 OS=Bos taurus OX=9913 GN=MTRF1 PE=3 SV=2 CANONICAL=Q3MHI7-1" }, "locus": { "chromosome": "12", "start_pos": 11460261, "end_pos": 11427368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016261.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016261.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016261.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016261.7" } ] } }, { "isoform_ac": "A0AAF7AP05-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#A0AAF7AP05-1", "sequence": { "sequence": "MSDSVQPHRRQPTRLLCPWDSPGKNTGVGCHFPLQCLKVKNAEMNRRHLFAWLFRHLSLNGHLQCHVHRHSHQLTQIPLDTRLWVFRRNRNHTVHRLLNKNCSRRYCHQDTSMLWKHKALQKYMEDLNKEYQTLDHCLHHISASEGDRRSLTRRHAELAPLAVIYKEIQEAEQAIEELESMCKSLNKQDEKQLQELALEERQTIAQKINMLYSELFQSLLPKEKYDKNDVILEVTSGRTTGGDICQQFTREIFDMYQNYSSYKHWRFELLNYTPADYGGLHHAAARISGDNVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPHPDEVDVKVDPKDLRIDTFRAKGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQIKNKEIALRVLRARLYQQIIEKDKCQQRSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRNIKEFLCGEKCLDQLIQRLLQSADEEAITEFLDENLKSVK", "length": 490, "header": "tr|A0AAF7AP05-1|A0AAF7AP05_BOVIN Computationally mapped isoform of Mitochondrial translation release factor 1 OS=Bos taurus OX=9913 GN=MTRF1 PE=3 SV=1 CANONICAL=Q3MHI7-1" }, "locus": { "chromosome": "12", "start_pos": 11461153, "end_pos": 11422802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075243.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075243.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072535.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072535.2" } ] } }, { "isoform_ac": "Q3MHI7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7/entry#Q3MHI7-1", "sequence": { "sequence": "MNRRHLFAWLFRHLSLNGHLQCHVHRHSHQLTQIPLDTRLWVFRRNRNHTVHRLLNKNCSRRYCHQDTSMLWKHKALQKYMEDLNKEYQTLDHCLHHISASEGDRRSLTRRHAELAPLAVIYKEIQEAEQAIEELESMCKSLNKQDEKQLQELALEERQTIAQKINMLYSELFQSLLPKEKYDKNDVILEVTSGRTTGGDICQQFTREIFDMYQNYSSYKHWRFELLNYTPADYGGLHHAAARISGDNVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPHPDEVDVKVDPKDLRIDTFRAKGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQIKNKEIALRVLRARLYQQIIEKDKCQQRSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRNIKEFLCGEKCLDQLIQRLLQSADEEAITEFLDENLKSVK", "length": 447, "header": "sp|Q3MHI7-1|RF1M_BOVIN Isoform 1 of Peptide chain release factor 1, mitochondrial OS=Bos taurus OX=9913 GN=MTRF1 PE=2 SV=1 CANONICAL=Q3MHI7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504754", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504754", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" } ], "orthologs": [ { "uniprot_canonical_ac": "A2RVR7-1", "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRVLIRPNFLSNLIRYCSRGTHSHDRSLRSVLSSNMIRLYTTGMEPQLSPDLIKIMDQRLSAIEHRNAVLQKLINQPEYSPEEFSRANKELRKLRDSMLLINDLRAKQKEIDGLKSLVSESSDDKDMLDLAVGELDEAVEEEKRLQTLLLKSLLPKDEADERDCILEVRAGTGGEEASLFAMDIFRMYERYSQKKGWKFDIVDITESDMKGYKEASAAICGASVYGKLKFESGIHRVQRIPITEKSGRIHTSAISVAILPQADEVDVQLRNEDLRIDTYRSGGSGGQHANTTNSAVRIIHLPTGMMVSIQDERSQHMNRAKALKVLCARLYEIERLRIQSSRSKLRSDQIGSGDRSGRIRTYNFPQGRVTDHRVGITHHAIEDMMQGENLDMFIDALLLRQEMDAIASFSSTS", "length": 413 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "E1BXF8-1", "protein_name": "Mitochondrial translation release factor 1", "gene_name": "MTRF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKPPQSIWLFKNLLSSCYCYGQLHNSPLPSVAKKISYVMRLHSCGFWRPESLLDTDRFTLSFHGWLRKKHQDSRALWKHEAVQKYLETLSKEYQQVDHLLNADSKNEFEQRTLRRRRADLSPVATAFQEIREAESELQELETMCRELDSRDEKQLLELALEEKETLDKKINTLCRKLFQLLVPKEKYDKSHVILEVTAGRTTGGDICQQFTKEMFEMYQNYADYKCWTFDILNYVPAEIGGLHHAAAHISGDDVYRHLKYEGGTHRVQRIPETGLSSRMQRIHTGTMSVIVLPQPEEVDVKVDPKDLRIDTFRAKGAGGQHVNKTDSAVRIVHLPTGVVVECQQERSQQMNKEIALRTLRAKLYQQIIEKQLSQEQSARKLQLGTRAQSERIRTYNFTQDRVTDHRISYDARNIKEILSGKEELDKLINRLLEFAEMEALTEYLENLQSVGGEGC", "length": 455 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RJ87-1", "protein_name": "Mitochondrial translation release factor 1", "gene_name": "MTRF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNRHLYVWLCRHPSLHRHRQCHVHLRSHRLTQTHLDTRPGAFRQDRNHLLCRLLNKSWSRRYCHQDTRMQWRHKALQKYMEDLSKEYQTLDRCLQHISAPEGDRRSLNRRHAELAPLAVIYKEIQEAEQAIEELESMCKSLNKQDEKQLQELALEEKRTIAQKINMLYHELFQSLVPKEKYDKNDVILEVTSGRTTGGDICQQFTREIFDMYQNYSSYKHWTFELLNYTPADYGGLHHAAARISGANVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKVDPKDLRIDTFRAKGAGGQHVNTTDSAVRLVHVPTGLVVECQQERSQIKNKEIALRVLRARLYQQIIEKEKCQQQSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRNIKEFLCGEKCLDLLIQRLLQTADEEAITEFLDENLKSAK", "length": 446 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HGU2-1", "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "Mtrf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHHLCIHLFRNPSYTRRHVFLYCQRFRQISLDTRLWDFKQNKSHVLHQVLNKSWSRSYCHQDPKMLWKHKALQKYMEGLNEEYQTLDGCLQDISGNEDSRRALCRRHAKLAPLAAIYQEIQEAEQAIEELESMCKTLHKQDEKQLQELVSEERQIIDQKINTLYSELLEQLVPKEKYDKSDVILEVTSGRTTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPDVGLSSRMQRIHTGTMSVIVLLQPDEVDVKVDPRDLRIDTFRSRGPGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQILEKDKCQQQSARKLQVGTRAQSERIRTYNFTQDRVTDHRIAFEVRDIKEFLRGEKCLDQLIQRLLQSADEEAIAEFLDESLKSVK", "length": 443 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0RDC8-1", "protein_name": "Mitochondrial translation release factor 1", "gene_name": "Mtrf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFHLCVWLFRNLSSLSACSQRHVFLYGQQFRQINLDPRLWNFRQNKTHVLYRLLNKSWSRGYCQGTRKLWKHKALQKYMEGLNDEYQSLDQCLQDISEDEGDRRASHRRHAELAPLVAVYQEIQEAEQAIEELESMCKSLNKQDEKQLQELVSEERQIIDQKIHRLYSELLEHLVPKEKCDRSNVILEVTSGRTTGGDICQQFTREIFDMYQNYSYYKHWRFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKVDPRDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDKCQQQNARKLQEFLRGEKCLDQLIERLLQSADEEAIAEFLDESLQSVK", "length": 413 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75570-1", "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "MTRF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRRYCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQLIQRLLQSADEEAIAELLDEHLKSAK", "length": 445 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54RE7-1", "protein_name": "Peptide chain release factor 1", "gene_name": "prfA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFRSLNKLLISNNLIIKKNNIIIPYNYKFSIKNNNNNNNNFIYRNFCNNNNNKNNNNNNNNIDELFNKTSIPPNIVFRLNLMGKKSKELRNMIDSNMGLGQSEIKKISKELQETAEPLGYFGDLIEKLKELKELQTMLVEETDEDGKQMIKSDINKLKQEEIEPLEKQLLFSLLPGSKDDAGDAILEIRAGTGGSEAQLFTQDVYEMYRSYCLQKGWTFEPLELSVTEVGGYRDVTVSVSGKGVFGFLKYESGVHRVQRVPLTETQGRIHTSTITVAILPEPKDVDIQIHDRDLKVDIYRSSGNGGQSVNTTDSAVRITHLPTGITVAMQDERSQHQNRSKAMKILKARIYERERIRLQNERVSERNAQIGSALRSERIRTYNYPQDRITDHRVSINGNLNSCMNSDGLDSFIDEILVEFHTKELEELLS", "length": 430 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8K126-1", "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "Mtrf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHHLCIWLFRNPFLRACPQRHVFLSCQQFRQISLDTRPWNFRQKKTHVLYQLLNKSWSRGCCHQGTRKLWKHKALQKYMEDLNKEYQTLDQCLQGISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWSDVILEVTSGRTTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRDIKEFLRGEKCLDQLIERLLQSADEEAISEFLDESLQSVK", "length": 446 }, "evidence": [ { "id": "Q3MHI7", "url": "https://omabrowser.org/oma/group/Q3MHI7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial translational termination", "id": "GO:0070126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070126", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "translation release factor activity, codon specific", "id": "GO:0016149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016149", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "pmid": "" }, { "name": "translation release factor activity", "id": "GO:0003747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003747", "evidence": [ { "database": "UniProtKB", "id": "Q3MHI7", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 447, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHI7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHI7" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "GGQ", "eco_id": "ECO_0000250", "start_pos": 313, "end_pos": 315, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHJ5-1", "uniprot_ac": "Q3MHJ5", "uniprot_id": "RM54_BOVIN", "mass": { "chemical_mass": 15951.0, "monoisotopic_mass": 15951.0 }, "refseq": { "ac": "NP_001030277", "name": "large ribosomal subunit protein mL54 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" }, "gene_names": [ { "name": "MRPL54", "type": "recommended", "evidence": [ { "id": "Q3MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ] }, { "name": "MRPL54", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL54", "type": "recommended", "evidence": [ { "id": "Q3MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L54, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" }, { "id": "Q3MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5/entry#names_and_taxonomy" } ] }, { "name": "L54mt", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" }, { "id": "Q3MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5/entry#names_and_taxonomy" } ] }, { "name": "MRP-L54", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" }, { "id": "Q3MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL54 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" } ] }, { "name": "large ribosomal subunit protein mL54", "type": "synonym", "evidence": [ { "id": "NP_001030277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL54", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5", "locus": { "chromosome": "7", "start_pos": 20209218, "end_pos": 20212341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008396", "url": "https://www.ensembl.org/id/ENSBTAG00000008396" } ] } } ], "crossref": [ { "id": "Q3MHJ5", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "511926", "url": "https://www.ncbi.nlm.nih.gov/gene/511926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHJ5", "url": "https://www.orthodb.org/?gene=Q3MHJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28595", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28595", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28595:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28595:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARRLFGATGSWARWRAWELPDPAGSVRLHVRDYAKRPVFKGGKGAKGAAVGETLKDPEVCTDPVQLTTHPMGVNIYKEGQDVVLKPDSEYPEWLFQMNVGPPKKLEELDPETREYWRLLRKHNIWRHNRLSKNQKF", "length": 138, "header": "sp|Q3MHJ5-1|RM54_BOVIN Isoform 1 of Large ribosomal subunit protein mL54 OS=Bos taurus OX=9913 GN=MRPL54 PE=1 SV=1 CANONICAL=Q3MHJ5-1" }, "isoforms": [ { "isoform_ac": "Q3MHJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5/entry#Q3MHJ5-1", "sequence": { "sequence": "MAARRLFGATGSWARWRAWELPDPAGSVRLHVRDYAKRPVFKGGKGAKGAAVGETLKDPEVCTDPVQLTTHPMGVNIYKEGQDVVLKPDSEYPEWLFQMNVGPPKKLEELDPETREYWRLLRKHNIWRHNRLSKNQKF", "length": 138, "header": "sp|Q3MHJ5-1|RM54_BOVIN Isoform 1 of Large ribosomal subunit protein mL54 OS=Bos taurus OX=9913 GN=MRPL54 PE=1 SV=1 CANONICAL=Q3MHJ5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] } ], "pathway": [ { "id": "bta:511926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511926", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3MHJ5", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHJ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 138, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHJ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHJ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHK4-1", "uniprot_ac": "Q3MHK4", "uniprot_id": "CLD11_BOVIN", "mass": { "chemical_mass": 22012.0, "monoisotopic_mass": 22012.0 }, "refseq": { "ac": "NP_001030227", "name": "claudin-11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030227" }, "gene_names": [ { "name": "CLDN11", "type": "recommended", "evidence": [ { "id": "Q3MHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ] }, { "name": "CLDN11", "type": "synonym", "evidence": [ { "id": "NP_001030227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030227" } ] } ], "protein_names": [ { "name": "Claudin-11", "type": "recommended", "evidence": [ { "id": "Q3MHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4/entry#names_and_taxonomy" } ] }, { "name": "claudin 11 (oligodendrocyte transmembrane protein)", "type": "synonym", "evidence": [ { "id": "NP_001030227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030227" } ] }, { "name": "claudin-11", "type": "synonym", "evidence": [ { "id": "NP_001030227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030227" } ] } ], "function": [ { "annotation": "Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4#function" }, { "database": "UniProtKB", "id": "O75508", "url": "https://www.uniprot.org/uniprotkb/O75508#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLDN11", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4", "locus": { "chromosome": "1", "start_pos": 96999963, "end_pos": 97014866, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019060", "url": "https://www.ensembl.org/id/ENSBTAG00000019060" } ] } } ], "crossref": [ { "id": "Q3MHK4", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "508268", "url": "https://www.ncbi.nlm.nih.gov/gene/508268", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508268", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508268", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHK4", "url": "https://www.orthodb.org/?gene=Q3MHK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030227", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHK4-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVMLVLVALCAMVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVIVCCAGDAQAFGENRFYYSSGSSSPTHAKSAHV", "length": 207, "header": "sp|Q3MHK4-1|CLD11_BOVIN Isoform 1 of Claudin-11 OS=Bos taurus OX=9913 GN=CLDN11 PE=2 SV=1 CANONICAL=Q3MHK4-1" }, "isoforms": [ { "isoform_ac": "Q3MHK4-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4/entry#Q3MHK4-1", "sequence": { "sequence": "MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVMLVLVALCAMVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVIVCCAGDAQAFGENRFYYSSGSSSPTHAKSAHV", "length": 207, "header": "sp|Q3MHK4-1|CLD11_BOVIN Isoform 1 of Claudin-11 OS=Bos taurus OX=9913 GN=CLDN11 PE=2 SV=1 CANONICAL=Q3MHK4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "site_lbl": "Ser193" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "site_lbl": "Ser194" }, { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "site_lbl": "Ser197" }, { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "site_lbl": "Ser198" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508268", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508268", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tight junction assembly", "id": "GO:0120192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120192", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q3MHK4", "url": "https://www.uniprot.org/uniprotkb/Q3MHK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHK4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 207, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHK4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHK4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 193, 194, 197, 198 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHR3-1", "uniprot_ac": "Q3MHR3", "uniprot_id": "DYL2_BOVIN", "mass": { "chemical_mass": 10350.0, "monoisotopic_mass": 10350.0 }, "refseq": { "ac": "NP_001106774", "name": "dynein light chain 2, cytoplasmic", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106774" }, "gene_names": [ { "name": "DYNLL2", "type": "recommended", "evidence": [ { "id": "Q3MHR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ] }, { "name": "DYNLL2", "type": "synonym", "evidence": [ { "id": "NP_001106774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106774" } ] } ], "protein_names": [ { "name": "Dynein light chain 2, cytoplasmic", "type": "recommended", "evidence": [ { "id": "Q3MHR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3/entry#names_and_taxonomy" } ] }, { "name": "dynein light chain 2, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001106774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106774" } ] } ], "function": [ { "annotation": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYNLL2", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3", "locus": { "chromosome": "19", "start_pos": 8893225, "end_pos": 8885982, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025313", "url": "https://www.ensembl.org/id/ENSBTAG00000025313" } ] } } ], "crossref": [ { "id": "Q3MHR3", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025313", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025313", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21452", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21452", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540369", "url": "https://www.ncbi.nlm.nih.gov/gene/540369", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540369", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540369", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THEKGHF", "url": "https://omabrowser.org/oma/group/THEKGHF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHR3", "url": "https://www.orthodb.org/?gene=Q3MHR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11886", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11886", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11886:SF113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11886:SF113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-139910", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139910", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3371497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9646399", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9646399", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHR3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89, "header": "sp|Q3MHR3-1|DYL2_BOVIN Isoform 1 of Dynein light chain 2, cytoplasmic OS=Bos taurus OX=9913 GN=DYNLL2 PE=3 SV=1 CANONICAL=Q3MHR3-1" }, "isoforms": [ { "isoform_ac": "Q3MHR3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3/entry#Q3MHR3-1", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89, "header": "sp|Q3MHR3-1|DYL2_BOVIN Isoform 1 of Dynein light chain 2, cytoplasmic OS=Bos taurus OX=9913 GN=DYNLL2 PE=3 SV=1 CANONICAL=Q3MHR3-1" }, "locus": { "chromosome": "19", "start_pos": 8891330, "end_pos": 8889003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150575.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150575.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107056.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540369", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540369", "resource": "KEGG Pathway" }, { "id": "R-BTA-139910", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139910", "resource": "Reactome", "description": "Activation of BMF and translocation to mitochondria" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-5620924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "resource": "Reactome", "description": "Intraflagellar transport" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" }, { "id": "R-BTA-9646399", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9646399", "resource": "Reactome", "description": "Aggrephagy" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SJK3-1", "protein_name": "Dynein light chain", "gene_name": "DYNLL2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H1E5-1", "protein_name": "Dynein light chain", "gene_name": "Dynll2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O96860-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "Cdlc2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDRKAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q02647-1", "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYN2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDENKSTPIVKASDITDKLKEDILTISKDALDKYQLERDIAGTVKKQLDVKYGNTWHVIVGKNFGSYVTHEKGHFVYFYIGPLAFLVFKTA", "length": 92 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q78P75-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "Dynll2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96FJ2-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "DYNLL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D0M5-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "Dynll2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG", "length": 89 }, "evidence": [ { "id": "Q3MHR3", "url": "https://omabrowser.org/oma/group/Q3MHR3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "myosin V complex", "id": "GO:0031475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031475", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "cytoplasmic dynein complex", "id": "GO:0005868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005868", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" }, { "name": "9+0 non-motile cilium", "id": "GO:0097731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097731", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule-based process", "id": "GO:0007017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR3", "url": "https://www.uniprot.org/uniprotkb/Q3MHR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHR3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 89, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHR3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHR3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHW0-1", "uniprot_ac": "Q3MHW0", "uniprot_id": "SRGEF_BOVIN", "mass": { "chemical_mass": 48955.0, "monoisotopic_mass": 48955.0 }, "refseq": { "ac": "NP_001069489", "name": "secretion-regulating guanine nucleotide exchange factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069489" }, "gene_names": [ { "name": "SERGEF", "type": "recommended", "evidence": [ { "id": "Q3MHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ] }, { "name": "SERGEF", "type": "synonym", "evidence": [ { "id": "NP_001069489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069489" } ] } ], "protein_names": [ { "name": "Secretion-regulating guanine nucleotide exchange factor", "type": "recommended", "evidence": [ { "id": "Q3MHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0/entry#names_and_taxonomy" } ] }, { "name": "secretion-regulating guanine nucleotide exchange factor", "type": "synonym", "evidence": [ { "id": "NP_001069489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069489" } ] } ], "function": [ { "annotation": "Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERGEF", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0", "locus": { "chromosome": "15", "start_pos": 34730575, "end_pos": 34481913, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005340", "url": "https://www.ensembl.org/id/ENSBTAG00000005340" } ] } } ], "crossref": [ { "id": "Q3MHW0", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005340", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005340", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534377", "url": "https://www.ncbi.nlm.nih.gov/gene/534377", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534377", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534377", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WRWGCSG", "url": "https://omabrowser.org/oma/group/WRWGCSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHW0", "url": "https://www.orthodb.org/?gene=Q3MHW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22870:SF466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22870:SF466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069489", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHW0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 464, "header": "sp|Q3MHW0-1|SRGEF_BOVIN Isoform 1 of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=2 SV=1 CANONICAL=Q3MHW0-1" }, "isoforms": [ { "isoform_ac": "Q3MHW0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0/entry#Q3MHW0-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 464, "header": "sp|Q3MHW0-1|SRGEF_BOVIN Isoform 1 of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=2 SV=1 CANONICAL=Q3MHW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 427, "end_pos": 427, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "site_lbl": "Ser427" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534377", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534377", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q80YD6-1", "protein_name": "Secretion-regulating guanine nucleotide exchange factor", "gene_name": "Sergef", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARESCASETVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGATEISCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVCQLPAHPVPCQDLKVTCPLPDDTENTESQGAVDRDRLEGETISDLNPDRTRNGGGGCESETVQ", "length": 464 }, "evidence": [ { "id": "Q3MHW0", "url": "https://omabrowser.org/oma/group/Q3MHW0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FN03-1", "protein_name": "Ultraviolet-B receptor UVR8", "gene_name": "UVR8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEDMAADEVTAPPRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSVDGASGQHIESSNIDPSSGKSWVSPAERYAVVPDETGLTDGSSKGNGGDISVPQTDVKRVRI", "length": 440 }, "evidence": [ { "id": "Q3MHW0", "url": "https://omabrowser.org/oma/group/Q3MHW0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of protein secretion", "id": "GO:0050709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050709", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW0", "url": "https://www.uniprot.org/uniprotkb/Q3MHW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 464, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHW0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 427 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHZ1-1", "uniprot_ac": "Q3MHZ1", "uniprot_id": "NAT14_BOVIN", "mass": { "chemical_mass": 21734.0, "monoisotopic_mass": 21734.0 }, "refseq": { "ac": "NP_001032322", "name": "probable N-acetyltransferase 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322" }, "gene_names": [ { "name": "NAT14", "type": "recommended", "evidence": [ { "id": "Q3MHZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ] }, { "name": "KLP1", "type": "synonym", "evidence": [ { "id": "NP_001032322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322" } ] }, { "name": "NAT14", "type": "synonym", "evidence": [ { "id": "NP_001032322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322" } ] } ], "protein_names": [ { "name": "Probable N-acetyltransferase 14", "type": "recommended", "evidence": [ { "id": "Q3MHZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.-", "type": "synonym", "evidence": [ { "id": "Q3MHZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1/entry#names_and_taxonomy" } ] }, { "name": "K562 cell-derived leucine-zipper-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001032322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322" } ] }, { "name": "probable N-acetyltransferase 14", "type": "synonym", "evidence": [ { "id": "NP_001032322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322" } ] } ], "function": [ { "annotation": "May act as a transcription factor regulating the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1#function" }, { "database": "UniProtKB", "id": "Q8WUY8", "url": "https://www.uniprot.org/uniprotkb/Q8WUY8#function" } ] }, { "annotation": "Probable acetyltransferase.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAT14", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1", "locus": {} } ], "crossref": [ { "id": "Q3MHZ1", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019051", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019051", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532809", "url": "https://www.ncbi.nlm.nih.gov/gene/532809", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532809", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532809", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PWVAVWG", "url": "https://omabrowser.org/oma/group/PWVAVWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHZ1", "url": "https://www.orthodb.org/?gene=Q3MHZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13947:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13947:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032322", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFVLASFALALLLPVFLAVAAMKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGSSAGDGARVTRLSVSRWHRRRGVGRRLLAFAESRARAWAGGMGEPRARLVVPVAVAAWGVAGMLEGCGYQAEGSWGCMGYTLVREFSKEL", "length": 206, "header": "sp|Q3MHZ1-1|NAT14_BOVIN Isoform 1 of Probable N-acetyltransferase 14 OS=Bos taurus OX=9913 GN=NAT14 PE=2 SV=1 CANONICAL=Q3MHZ1-1" }, "isoforms": [ { "isoform_ac": "Q3MHZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1/entry#Q3MHZ1-1", "sequence": { "sequence": "MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFVLASFALALLLPVFLAVAAMKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGSSAGDGARVTRLSVSRWHRRRGVGRRLLAFAESRARAWAGGMGEPRARLVVPVAVAAWGVAGMLEGCGYQAEGSWGCMGYTLVREFSKEL", "length": 206, "header": "sp|Q3MHZ1-1|NAT14_BOVIN Isoform 1 of Probable N-acetyltransferase 14 OS=Bos taurus OX=9913 GN=NAT14 PE=2 SV=1 CANONICAL=Q3MHZ1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532809", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532809", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BEB8-1", "protein_name": "Probable N-acetyltransferase 14", "gene_name": "NAT14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFVLASFALALLLPVFLAVAAMKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGSSAGDGARVTRLSVSRWHRRQGVGRRLLAFAESRARAWAGGMGEPRARLVVPVAVAAWGVAGMLEGCGYQAEGSWGCMGYTLVREFSKDL", "length": 206 }, "evidence": [ { "id": "Q3MHZ1", "url": "https://omabrowser.org/oma/group/Q3MHZ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BVG8-1", "protein_name": "Probable N-acetyltransferase 14", "gene_name": "Nat14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPNHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFILASFALALLLPVFLAVAAVKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGANVGDGARVTRLSVSRWHRRRGVGRRLLAFAEARARAWAGSMGEPRARLVVPVAVAAWGVAGLLEACGYQAEGGWGCMGYMLVREFSKDL", "length": 206 }, "evidence": [ { "id": "Q3MHZ1", "url": "https://omabrowser.org/oma/group/Q3MHZ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WUY8-1", "protein_name": "Probable N-acetyltransferase 14", "gene_name": "NAT14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFVLASFALALLLPVFLAVAAVKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGTNAGDGARVTRLSVSRWHRRRGVGRRLLAFAEARARAWAGGMGEPRARLVVPVAVAAWGVGGMLEGCGYQAEGGWGCLGYTLVREFSKDL", "length": 206 }, "evidence": [ { "id": "Q3MHZ1", "url": "https://omabrowser.org/oma/group/Q3MHZ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ], "pmid": "" }, { "name": "N-acetyltransferase activity", "id": "GO:0008080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008080", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ1", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 206, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHZ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ1" }, { "id": "PRU00532", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00532" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-acetyltransferase", "eco_id": "ECO_0000255", "start_pos": 55, "end_pos": 206, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MIC0-1", "uniprot_ac": "Q3MIC0", "uniprot_id": "RL37A_BOVIN", "mass": { "chemical_mass": 10275.0, "monoisotopic_mass": 10275.0 }, "refseq": { "ac": "NP_001030180", "name": "large ribosomal subunit protein eL43", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030180" }, "gene_names": [ { "name": "RPL37A", "type": "recommended", "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ] }, { "name": "RPL37A", "type": "synonym", "evidence": [ { "id": "NP_001030180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030180" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL43", "type": "recommended", "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L37a", "type": "synonym", "evidence": [ { "id": "NP_001030180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030180" }, { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL43", "type": "synonym", "evidence": [ { "id": "NP_001030180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030180" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0#function" }, { "database": "UniProtKB", "id": "P61513", "url": "https://www.uniprot.org/uniprotkb/P61513#function" }, { "database": "UniProtKB", "id": "A0AAA9T3C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3C7#function" }, { "database": "UniProtKB", "id": "ARBA00034092", "url": "https://www.uniprot.org/uniprotkb/ARBA00034092#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL37A", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0", "locus": {} } ], "crossref": [ { "id": "Q3MIC0", "url": "https://alphafold.ebi.ac.uk/entry/Q3MIC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051254", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051254", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504413", "url": "https://www.ncbi.nlm.nih.gov/gene/504413", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504413", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504413", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPRYGRK", "url": "https://omabrowser.org/oma/group/GPRYGRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MIC0", "url": "https://www.orthodb.org/?gene=Q3MIC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48188:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48188:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030180", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MIC0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92, "header": "sp|Q3MIC0-1|RL37A_BOVIN Isoform 1 of Large ribosomal subunit protein eL43 OS=Bos taurus OX=9913 GN=RPL37A PE=3 SV=3 CANONICAL=Q3MIC0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3C7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0/entry#A0AAA9T3C7-1", "sequence": { "sequence": "MHIRAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 95, "header": "tr|A0AAA9T3C7-1|A0AAA9T3C7_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL43 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3MIC0-1" }, "locus": {} }, { "isoform_ac": "Q3MIC0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0/entry#Q3MIC0-1", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92, "header": "sp|Q3MIC0-1|RL37A_BOVIN Isoform 1 of Large ribosomal subunit protein eL43 OS=Bos taurus OX=9913 GN=RPL37A PE=3 SV=3 CANONICAL=Q3MIC0-1" }, "locus": { "chromosome": "2", "start_pos": 104489677, "end_pos": 104487441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133385.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133385.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090198.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090198.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504413", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504413", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UMQ6-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "RPL37A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H3Z5-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "Rpl37a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0CX25-1", "protein_name": "Large ribosomal subunit protein eL43A", "gene_name": "RPL43A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX26-1", "protein_name": "Large ribosomal subunit protein eL43B", "gene_name": "RPL43B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P32046-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "RPL37A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRKAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P61513-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "RPL37A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61514-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "Rpl37a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54UG4-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "rpl37A", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAKRTKKVGVVGKYGTRYGASLRKQVKKMEITQHGTYTCSFCGKDAVRRSSVGIWKCNGCRKVLAGGAWTMSTAAGATVRSTIRRLRELNN", "length": 91 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SRK6-1", "protein_name": "Large ribosomal subunit protein eL43z", "gene_name": "RPL37AB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTKRTKKARIVGKYGTRYGASLRKQIKKMEVSQHNKYFCEFCGKYSVKRKVVGIWGCKDCGKVKAGGAYTMNTASAVTVRSTIRRLREQTES", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VMU4-1", "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "RpL37A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAKRTKKVGIVGKYGTRYGASLRKMVKKMEITQHSKYTCSFCGKDSMKRAVVGIWSCKRCKRTVAGGAWVYSTTAAASVRSAVRRLRETKEQ", "length": 92 }, "evidence": [ { "id": "Q3MIC0", "url": "https://omabrowser.org/oma/group/Q3MIC0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3MIC0", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MIC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 92, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MIC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MIC0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0#function" }, { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "binding_site_uniprot": 39, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 39, "end_pos": 39, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0#function" }, { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "binding_site_uniprot": 42, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 42, "end_pos": 42, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0#function" }, { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "binding_site_uniprot": 57, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 57, "end_pos": 57, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0#function" }, { "id": "Q3MIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MIC0" } ], "binding_site_uniprot": 60, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 60, "end_pos": 60, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SWX1-1", "uniprot_ac": "Q3SWX1", "uniprot_id": "CNPY4_BOVIN", "mass": { "chemical_mass": 27369.0, "monoisotopic_mass": 27369.0 }, "refseq": { "ac": "NP_001029425", "name": "protein canopy homolog 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" }, "gene_names": [ { "name": "CNPY4", "type": "recommended", "evidence": [ { "id": "Q3SWX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1" } ] }, { "name": "CNPY4", "type": "synonym", "evidence": [ { "id": "NP_001029425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" } ] }, { "name": "CNPY", "type": "synonym", "evidence": [ { "id": "NP_001029425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" } ] } ], "protein_names": [ { "name": "Protein canopy homolog 4", "type": "recommended", "evidence": [ { "id": "Q3SWX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1/entry#names_and_taxonomy" } ] }, { "name": "canopy 4 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" } ] }, { "name": "protein canopy homolog 4 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" } ] }, { "name": "protein canopy homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001029425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425" } ] } ], "function": [ { "annotation": "Plays a role in the regulation of the cell surface expression of TLR4.", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWX1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNPY4", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1", "locus": {} } ], "crossref": [ { "id": "Q3SWX1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007016", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505637", "url": "https://www.ncbi.nlm.nih.gov/gene/505637", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505637", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505637", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKFLTME", "url": "https://omabrowser.org/oma/group/CKFLTME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SWX1", "url": "https://www.orthodb.org/?gene=Q3SWX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15382:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15382:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SWX1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPVRLGTLLFILTVYGAWAGTPKEEEDDTERLPSKCEVCKLLSLELQEELSRTGRSREVLELGQVLDTGKRKRHIPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEQFEDVVGDWYFHHQEQPLQHFLCEGHVLPASETACLQETWTGKEKITDGQEKTEEEEQDQEEEEMTNTPVHSQHDPEDL", "length": 239, "header": "sp|Q3SWX1-1|CNPY4_BOVIN Isoform 1 of Protein canopy homolog 4 OS=Bos taurus OX=9913 GN=CNPY4 PE=2 SV=1 CANONICAL=Q3SWX1-1" }, "isoforms": [ { "isoform_ac": "Q3SWX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1/entry#Q3SWX1-1", "sequence": { "sequence": "MGPVRLGTLLFILTVYGAWAGTPKEEEDDTERLPSKCEVCKLLSLELQEELSRTGRSREVLELGQVLDTGKRKRHIPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEQFEDVVGDWYFHHQEQPLQHFLCEGHVLPASETACLQETWTGKEKITDGQEKTEEEEQDQEEEEMTNTPVHSQHDPEDL", "length": 239, "header": "sp|Q3SWX1-1|CNPY4_BOVIN Isoform 1 of Protein canopy homolog 4 OS=Bos taurus OX=9913 GN=CNPY4 PE=2 SV=1 CANONICAL=Q3SWX1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505637", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505637", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQG2-1", "protein_name": "Canopy FGF signaling regulator 4", "gene_name": "CNPY4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPVPLGMLLFILTMYGACAGTMKEEDDDTERLPSKCEVCKLLSLELQEELSRTGRSREVLELGQVLDTGKRKRHIPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVVGDWYFHHQEQPLQRFLCEAHVLPAAETACLQETWTGNEKIADGQEKTAGEEEQDQEEEEEMTDSPGHPKHDPEDL", "length": 241 }, "evidence": [ { "id": "Q3SWX1", "url": "https://omabrowser.org/oma/group/Q3SWX1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JPI0-1", "protein_name": "Protein canopy homolog 4 isoform X1", "gene_name": "Cnpy4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRGLRFVMGPERLEILLFILAAYSAWAGTTKKEEDDTERLPSKCEVCKLLSLELQEELSRTGRSREVLDLGQVLDTGERKRRVPYSLSETRLEEALENLCERILDYSVHAEHKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTLLKKQCETMLEEFEDVVGDWYFHHQEQSLQHFLCEGHVLPASETACLQETWTGKEKSSDGHEEAEEEEEEEITKTSGNRKHDPEDL", "length": 242 }, "evidence": [ { "id": "Q3SWX1", "url": "https://omabrowser.org/oma/group/Q3SWX1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BQ47-1", "protein_name": "Protein canopy homolog 4", "gene_name": "Cnpy4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCGLRFIMGPVRLEILLFILAAYGAWAEATKEEEDDTERLPSKCEVCKLLSMELQEALSRTGRSREVLELGQVLDTGKRKRHVPYSLSETRLEEALENLCERILDYNVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVVGDWYFHHQEQPLQHFLCERHVLPASETACLREAWTGKEKISDGQEEADDEEEEEEEEITKTSGNPKHDPEDL", "length": 245 }, "evidence": [ { "id": "Q3SWX1", "url": "https://omabrowser.org/oma/group/Q3SWX1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N129-1", "protein_name": "Protein canopy homolog 4", "gene_name": "CNPY4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEEEGGDKMTKTGSHPKLDREDL", "length": 248 }, "evidence": [ { "id": "Q3SWX1", "url": "https://omabrowser.org/oma/group/Q3SWX1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VVW7-1", "protein_name": "Canopy b", "gene_name": "CNPYb", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLLKRLPGFVTLWVVLQLAGADSPEEEQGVRYANRCEACKILATELEARLGETGKSHDVIEIGYSVDDVKPKKRTEYRRSELRLLESLENVCERVLEYNLHKERSDSTRFAKGMSQTFQTLHGLVDKGVKVDLGIPYELWDKPPVEVTQMKTQCENLLEEYEETISEWYFKHQDEKSLKKHLCEDHVLKKKAERECLKEQLAPPEAKKAKREKAKGDKEEL", "length": 221 }, "evidence": [ { "id": "Q3SWX1", "url": "https://omabrowser.org/oma/group/Q3SWX1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 239, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX04-1", "uniprot_ac": "Q3SX04", "uniprot_id": "T3HPD_BOVIN", "mass": { "chemical_mass": 37957.0, "monoisotopic_mass": 37957.0 }, "refseq": { "ac": "NP_001029558", "name": "trans-L-3-hydroxyproline dehydratase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" }, "gene_names": [ { "name": "L3HYPDH", "type": "recommended", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ] }, { "name": "C10H14orf149", "type": "synonym", "evidence": [ { "id": "NP_001029558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" } ] }, { "name": "L3HYPDH", "type": "synonym", "evidence": [ { "id": "NP_001029558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" } ] } ], "protein_names": [ { "name": "Trans-L-3-hydroxyproline dehydratase", "type": "recommended", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.77", "type": "synonym", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04/entry#names_and_taxonomy" } ] }, { "name": "Trans-3-hydroxy-L-proline dehydratase", "type": "synonym", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04/entry#names_and_taxonomy" } ] }, { "name": "probable proline racemase", "type": "synonym", "evidence": [ { "id": "NP_001029558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" } ] }, { "name": "trans-3-hydroxy-l-proline dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001029558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" } ] }, { "name": "trans-L-3-hydroxyproline dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001029558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558" } ] } ], "function": [ { "annotation": "Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX04", "url": "https://www.uniprot.org/uniprotkb/Q3SX04#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX04", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "L3HYPDH", "url": "https://www.uniprot.org/uniprotkb/Q3SX04", "locus": { "chromosome": "10", "start_pos": 71661640, "end_pos": 71759825, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030824", "url": "https://www.ensembl.org/id/ENSBTAG00000030824" } ] } } ], "crossref": [ { "id": "Q3SX04", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030824", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030824", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510525", "url": "https://www.ncbi.nlm.nih.gov/gene/510525", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510525", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510525", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHVLWTG", "url": "https://omabrowser.org/oma/group/SHVLWTG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX04", "url": "https://www.orthodb.org/?gene=Q3SX04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33442:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33442:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029558", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10320", "url": "https://www.rhea-db.org/rhea/10320", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX04", "url": "https://www.uniprot.org/uniprotkb/Q3SX04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX04-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPLTVPWMPPHDPGTPALSVVDMHTGGEPLRIVLAGCPEVVGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLNNEGYSSMCGHAVLALGRFALDFGLVPAPPSDAQEALVNIHCPCGLVAAFVECEGCRSRGPVRFHSVPAFVLATDFLVDVPGRGKVVVDIAYGGAFYAFVSAEKLGLDVCSAKMGDLVAAASAVTEAVKAQFKISHPDSEDLAFLYGTILTDGKDTYNEEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLLK", "length": 354, "header": "sp|Q3SX04-1|T3HPD_BOVIN Isoform 1 of Trans-L-3-hydroxyproline dehydratase OS=Bos taurus OX=9913 GN=L3HYPDH PE=2 SV=1 CANONICAL=Q3SX04-1" }, "isoforms": [ { "isoform_ac": "Q3SX04-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX04/entry#Q3SX04-1", "sequence": { "sequence": "MAGPLTVPWMPPHDPGTPALSVVDMHTGGEPLRIVLAGCPEVVGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLNNEGYSSMCGHAVLALGRFALDFGLVPAPPSDAQEALVNIHCPCGLVAAFVECEGCRSRGPVRFHSVPAFVLATDFLVDVPGRGKVVVDIAYGGAFYAFVSAEKLGLDVCSAKMGDLVAAASAVTEAVKAQFKISHPDSEDLAFLYGTILTDGKDTYNEEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLLK", "length": 354, "header": "sp|Q3SX04-1|T3HPD_BOVIN Isoform 1 of Trans-L-3-hydroxyproline dehydratase OS=Bos taurus OX=9913 GN=L3HYPDH PE=2 SV=1 CANONICAL=Q3SX04-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:510525", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510525", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZTS1-1", "protein_name": "trans-L-3-hydroxyproline dehydratase", "gene_name": "L3HYPDH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASRLPVAQLPPHDPGTPALSVVDMHTGGEPLRIVLAGCPEVAGPTLLAKRRYMRQHLDYVRRRLMFEPRGHRDMYGAVLVPSELPEAHLGVLFLHNEGYSSMCGHAVLALGRFALDYGLVSAPPTGAREALVNIHCPCGLVTAFVECEGGRSRGPVRFHSVPAFALATDLLVDVPGRGKVVVDIAYGGAFYAFVSAEKLGLDVCSSKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDTYSEEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLKLNQTRAFKSSATSSIFTGKAVRETKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLLK", "length": 354 }, "evidence": [ { "id": "Q3SX04", "url": "https://omabrowser.org/oma/group/Q3SX04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9PML3-1", "protein_name": "trans-L-3-hydroxyproline dehydratase", "gene_name": "l3hypdh", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAFPKLPPHCGSVLSVVDMHTGGEPLRIILSGFPEVQGDTILAKRRYVREHLDHLRKVLMLEPRGHNDMYGALLVKSELAEADLGVLFLHNEGYSTMCGHAVIALGRFAVDYGLVKEPSSPETQINIHCPCGLVKAFTQYADGKTGAVRFHSVPAFAFATDVSVSVEGYGTVTVDISYGGALYAFVSAEKFGSDVNKSKTRDLVDAATAVSEAVKSQVKLYHPVSEDLAFLYGTILTDGKDAFSEEPTANMCVFADAQVDRSPTGSGVTARVALQYHKGLIRLNQTRSFQSGATGSVFTGTAIEETTCGDFKAVVVEVKGHAHYSGVATFTQESDDPLSGGFLLR", "length": 345 }, "evidence": [ { "id": "Q3SX04", "url": "https://omabrowser.org/oma/group/Q3SX04/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96EM0-1", "protein_name": "Trans-3-hydroxy-L-proline dehydratase", "gene_name": "L3HYPDH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPGHGKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIIEDDDPLRDGFLLK", "length": 354 }, "evidence": [ { "id": "Q3SX04", "url": "https://omabrowser.org/oma/group/Q3SX04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXA2-1", "protein_name": "Trans-L-3-hydroxyproline dehydratase", "gene_name": "L3hypdh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAALAVTRLPPNDPRTPALSVVDMHTGGEPLRIVHAGCPEVAGPTLLAKRRYMRQHLDYIRRRLVFEPRGHRDMYGAILVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPAPPKGAREAQVNIHCPCGLVTAFVECEGGRSCGPVRFHSVPAFVLASDLTVDVPGHGKVLVDIAYGGAFYAFVSAEKLGLDVCSAKTRDLVDAASALTGAVKAQFKINHPESEDLGFLYGSILTDGKDAYSEEATTNICVFADEQVDRSPTGSGVTARIALQYHKGLLQLNQTRAFKSSATGSVFTGCAVREAKCGDFKAVIVEVAGQAHYTGTANLTVEDGDPLRDGFLLK", "length": 354 }, "evidence": [ { "id": "Q3SX04", "url": "https://omabrowser.org/oma/group/Q3SX04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "trans-L-3-hydroxyproline dehydratase activity", "id": "GO:0050346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050346", "evidence": [ { "database": "UniProtKB", "id": "Q3SX04", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ], "pmid": "" }, { "name": "hydro-lyase activity", "id": "GO:0016836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016836", "evidence": [ { "database": "UniProtKB", "id": "Q3SX04", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10320", "name": "", "equation": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX04-1", "A0AAA9TBV7-1" ], "evidence": [ { "id": "10320", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10320" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TBV7", "gene_name": "L3HYPDH", "activity": [ { "ec_number": "4.2.1.77", "activity": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O.", "evidence": [ { "id": "A0AAA9TBV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV7" } ] }, { "ec_number": "4.2.1.77", "activity": "", "evidence": [ { "id": "A0AAA9TBV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV7" } ] } ] }, { "uniprot_ac": "Q3SX04", "gene_name": "L3HYPDH", "activity": [ { "ec_number": "4.2.1.77", "activity": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O.", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ] }, { "ec_number": "4.2.1.77", "activity": "", "evidence": [ { "id": "Q3SX04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX04" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX04" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.77", "ec_name": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O.", "evidence": [ { "id": "4.2.1.77", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.77" }, { "id": "4.2.1.77", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.77" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 293, "end_pos": 295 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX13-1", "uniprot_ac": "Q3SX13", "uniprot_id": "IPKA_BOVIN", "mass": { "chemical_mass": 8016.0, "monoisotopic_mass": 8016.0 }, "refseq": { "ac": "NP_001032709", "name": "cAMP-dependent protein kinase inhibitor alpha", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709" }, "gene_names": [ { "name": "PKIA", "type": "recommended", "evidence": [ { "id": "Q3SX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX13" } ] }, { "name": "PKIA", "type": "synonym", "evidence": [ { "id": "NP_001032709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709" } ] } ], "protein_names": [ { "name": "cAMP-dependent protein kinase inhibitor alpha", "type": "recommended", "evidence": [ { "id": "Q3SX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX13/entry#names_and_taxonomy" } ] }, { "name": "PKI-alpha", "type": "synonym", "evidence": [ { "id": "NP_001032709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709" }, { "id": "Q3SX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX13/entry#names_and_taxonomy" } ] }, { "name": "cAMP-dependent protein kinase inhibitor alpha", "type": "synonym", "evidence": [ { "id": "NP_001032709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709" } ] }, { "name": "protein kinase (cAMP-dependent, catalytic) inhibitor alpha", "type": "synonym", "evidence": [ { "id": "NP_001032709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709" } ] } ], "function": [ { "annotation": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.", "evidence": [ { "database": "UniProtKB", "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PKIA", "url": "https://www.uniprot.org/uniprotkb/Q3SX13", "locus": { "chromosome": "14", "start_pos": 41820938, "end_pos": 41721020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008150", "url": "https://www.ensembl.org/id/ENSBTAG00000008150" } ] } } ], "crossref": [ { "id": "Q3SX13", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX13", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613524", "url": "https://www.ncbi.nlm.nih.gov/gene/613524", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2GNJ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2GNJ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "2UZT", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2UZT&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "2UZU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2UZU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "2UZV", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2UZV&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "2UZW", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2UZW&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3E8C", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3E8C&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3E8E", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3E8E&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3ZO1", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3ZO1&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3ZO2", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3ZO2&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3ZO3", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3ZO3&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3ZO4", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3ZO4&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C33", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C33&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C34", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C34&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C35", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C35&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C36", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C36&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C37", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C37&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4C38", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4C38&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4YXR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4YXR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "5VHB", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5VHB&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "5VI9", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5VI9&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "5VIB", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5VIB&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8SF8", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SF8&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR004171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613524", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613524", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX13", "url": "https://www.orthodb.org/?gene=Q3SX13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00002gnj", "url": "https://www.rcsb.org/structure/pdb_00002gnj", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002uzt", "url": "https://www.rcsb.org/structure/pdb_00002uzt", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002uzu", "url": "https://www.rcsb.org/structure/pdb_00002uzu", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002uzv", "url": "https://www.rcsb.org/structure/pdb_00002uzv", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002uzw", "url": "https://www.rcsb.org/structure/pdb_00002uzw", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003e8c", "url": "https://www.rcsb.org/structure/pdb_00003e8c", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003e8e", "url": "https://www.rcsb.org/structure/pdb_00003e8e", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003zo1", "url": "https://www.rcsb.org/structure/pdb_00003zo1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003zo2", "url": "https://www.rcsb.org/structure/pdb_00003zo2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003zo3", "url": "https://www.rcsb.org/structure/pdb_00003zo3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003zo4", "url": "https://www.rcsb.org/structure/pdb_00003zo4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c33", "url": "https://www.rcsb.org/structure/pdb_00004c33", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c34", "url": "https://www.rcsb.org/structure/pdb_00004c34", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c35", "url": "https://www.rcsb.org/structure/pdb_00004c35", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c36", "url": "https://www.rcsb.org/structure/pdb_00004c36", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c37", "url": "https://www.rcsb.org/structure/pdb_00004c37", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004c38", "url": "https://www.rcsb.org/structure/pdb_00004c38", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004yxr", "url": "https://www.rcsb.org/structure/pdb_00004yxr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00005vhb", "url": "https://www.rcsb.org/structure/pdb_00005vhb", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00005vi9", "url": "https://www.rcsb.org/structure/pdb_00005vi9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00005vib", "url": "https://www.rcsb.org/structure/pdb_00005vib", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008sf8", "url": "https://www.rcsb.org/structure/pdb_00008sf8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2GNJ", "url": "https://www.rcsb.org/structure/2GNJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2UZT", "url": "https://www.rcsb.org/structure/2UZT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2UZU", "url": "https://www.rcsb.org/structure/2UZU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2UZV", "url": "https://www.rcsb.org/structure/2UZV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2UZW", "url": "https://www.rcsb.org/structure/2UZW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3E8C", "url": "https://www.rcsb.org/structure/3E8C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3E8E", "url": "https://www.rcsb.org/structure/3E8E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3ZO1", "url": "https://www.rcsb.org/structure/3ZO1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3ZO2", "url": "https://www.rcsb.org/structure/3ZO2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3ZO3", "url": "https://www.rcsb.org/structure/3ZO3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3ZO4", "url": "https://www.rcsb.org/structure/3ZO4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C33", "url": "https://www.rcsb.org/structure/4C33", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C34", "url": "https://www.rcsb.org/structure/4C34", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C35", "url": "https://www.rcsb.org/structure/4C35", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C36", "url": "https://www.rcsb.org/structure/4C36", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C37", "url": "https://www.rcsb.org/structure/4C37", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C38", "url": "https://www.rcsb.org/structure/4C38", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4YXR", "url": "https://www.rcsb.org/structure/4YXR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VHB", "url": "https://www.rcsb.org/structure/5VHB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VI9", "url": "https://www.rcsb.org/structure/5VI9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VIB", "url": "https://www.rcsb.org/structure/5VIB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SF8", "url": "https://www.rcsb.org/structure/8SF8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF02827", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02827", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX13-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRNSTEQSGEAQGEAAKSES", "length": 76, "header": "sp|Q3SX13-1|IPKA_BOVIN Isoform 1 of cAMP-dependent protein kinase inhibitor alpha OS=Bos taurus OX=9913 GN=PKIA PE=1 SV=3 CANONICAL=Q3SX13-1" }, "isoforms": [ { "isoform_ac": "Q3SX13-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX13/entry#Q3SX13-1", "sequence": { "sequence": "MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRNSTEQSGEAQGEAAKSES", "length": 76, "header": "sp|Q3SX13-1|IPKA_BOVIN Isoform 1 of cAMP-dependent protein kinase inhibitor alpha OS=Bos taurus OX=9913 GN=PKIA PE=1 SV=3 CANONICAL=Q3SX13-1" }, "locus": { "chromosome": "14", "start_pos": 41817526, "end_pos": 41813537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074880.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074880.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068262.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613524", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613524", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FGF5-1", "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "PKIA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLCHDKNSLFSYFATIFSGVKLACHPVTIWLMTQCHYKNHVSSFIDPTLLGSIYVDALICFHRGDSLLCGYLLAMTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRNSTEQSGEAQGEAAKSES", "length": 150 }, "evidence": [ { "id": "Q3SX13", "url": "https://omabrowser.org/oma/group/Q3SX13/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P61925-1", "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "PKIA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSSTEQSGEAQGEAAKSES", "length": 76 }, "evidence": [ { "id": "Q3SX13", "url": "https://omabrowser.org/oma/group/Q3SX13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P63248-1", "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "Pkia", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEDDGQRSSTEQSGEAQGEAAKSES", "length": 76 }, "evidence": [ { "id": "Q3SX13", "url": "https://omabrowser.org/oma/group/Q3SX13/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q90641-1", "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "PKIA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTDVESTYADFIASGRTGRRNALHDILVSSPGGNSSELALKLSELDINKAEGEGDAQRNPSEQTGEAQGEAAKQES", "length": 76 }, "evidence": [ { "id": "Q3SX13", "url": "https://omabrowser.org/oma/group/Q3SX13/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cAMP-dependent protein kinase inhibitor activity", "id": "GO:0004862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004862", "evidence": [ { "database": "UniProtKB", "id": "Q3SX13", "url": "https://www.uniprot.org/uniprotkb/Q3SX13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 76, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX13" }, { "pdb_id": "4c38", "pdb_chain": "i", "start_pos": 6, "end_pos": 25, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/4c38.pdb", "url_external": "https://www.rcsb.org/structure/4c38" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX20-1", "uniprot_ac": "Q3SX20", "uniprot_id": "BORC6_BOVIN", "mass": { "chemical_mass": 37171.0, "monoisotopic_mass": 37171.0 }, "refseq": { "ac": "NP_001035655", "name": "BLOC-1-related complex subunit 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" }, "gene_names": [ { "name": "BORCS6", "type": "recommended", "evidence": [ { "id": "Q3SX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ] }, { "name": "BORCS6", "type": "synonym", "evidence": [ { "id": "NP_001035655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" } ] }, { "name": "C17orf59", "type": "synonym", "evidence": [ { "id": "NP_001035655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" } ] }, { "name": "C19H17orf59", "type": "synonym", "evidence": [ { "id": "NP_001035655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" } ] } ], "protein_names": [ { "name": "BLOC-1-related complex subunit 6", "type": "recommended", "evidence": [ { "id": "Q3SX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX20/entry#names_and_taxonomy" } ] }, { "name": "BLOC-1-related complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001035655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" } ] }, { "name": "uncharacterized protein C17orf59 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655" } ] } ], "function": [ { "annotation": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20#function" }, { "database": "UniProtKB", "id": "Q96GS4", "url": "https://www.uniprot.org/uniprotkb/Q96GS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BORCS6", "url": "https://www.uniprot.org/uniprotkb/Q3SX20", "locus": { "chromosome": "19", "start_pos": 27833760, "end_pos": 27829937, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001711", "url": "https://www.ensembl.org/id/ENSBTAG00000001711" } ] } } ], "crossref": [ { "id": "Q3SX20", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX20", "database": "AlphaFoldDB", "categories": [] }, { "id": "539395", "url": "https://www.ncbi.nlm.nih.gov/gene/539395", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539395", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539395", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX20", "url": "https://www.orthodb.org/?gene=Q3SX20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13440", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13440", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13440:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13440:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035655", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX20-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESPRGRPGPETDLLALGEQQAAIFGDGPGQTPSERPSDLRLSEDEEAENVGGASCHPKASLKTSSCSFVHPPEWEAPEDKPGRGGTFSGAGSRLGAPDPEFDLHGSSRRKDPEPPEAKPESERVCRRGSPVGGGMDVEQKEDDNEAAEAGRGGRSFSSRLQDSRSLDGLSGACGGPASSGGAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPQPPPPAPTRPCSAPTPTPAIPPIDPDVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK", "length": 353, "header": "sp|Q3SX20-1|BORC6_BOVIN Isoform 1 of BLOC-1-related complex subunit 6 OS=Bos taurus OX=9913 GN=BORCS6 PE=2 SV=2 CANONICAL=Q3SX20-1" }, "isoforms": [ { "isoform_ac": "Q3SX20-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX20/entry#Q3SX20-1", "sequence": { "sequence": "MESPRGRPGPETDLLALGEQQAAIFGDGPGQTPSERPSDLRLSEDEEAENVGGASCHPKASLKTSSCSFVHPPEWEAPEDKPGRGGTFSGAGSRLGAPDPEFDLHGSSRRKDPEPPEAKPESERVCRRGSPVGGGMDVEQKEDDNEAAEAGRGGRSFSSRLQDSRSLDGLSGACGGPASSGGAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPQPPPPAPTRPCSAPTPTPAIPPIDPDVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK", "length": 353, "header": "sp|Q3SX20-1|BORC6_BOVIN Isoform 1 of BLOC-1-related complex subunit 6 OS=Bos taurus OX=9913 GN=BORCS6 PE=2 SV=2 CANONICAL=Q3SX20-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 244, "start_aa": "Thr", "end_pos": 244, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr244", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 246, "start_aa": "Thr", "end_pos": 246, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr246", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "site_lbl": "Ser130" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "site_lbl": "Ser166" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "site_lbl": "Thr194" }, { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "site_lbl": "Ser197" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539395", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539395", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "Q3SX20", "url": "https://www.uniprot.org/uniprotkb/Q3SX20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX20-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 353, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX20-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX20" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 244, 246 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 130, 166, 194, 197 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX22-1", "uniprot_ac": "Q3SX22", "uniprot_id": "BSDC1_BOVIN", "mass": { "chemical_mass": 50343.0, "monoisotopic_mass": 50343.0 }, "refseq": { "ac": "NP_001240651", "name": "BSD domain-containing protein 1 isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240651" }, "gene_names": [ { "name": "BSDC1", "type": "recommended", "evidence": [ { "id": "Q3SX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ] }, { "name": "BSDC1", "type": "synonym", "evidence": [ { "id": "NP_001240651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240651" } ] } ], "protein_names": [ { "name": "BSD domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3SX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#names_and_taxonomy" } ] }, { "name": "BSD domain-containing protein 1 isoform b", "type": "synonym", "evidence": [ { "id": "NP_001240651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240651" } ] }, { "name": "BSD domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001240651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240651" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BSDC1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22", "locus": { "chromosome": "2", "start_pos": 121199856, "end_pos": 121176424, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020655", "url": "https://www.ensembl.org/id/ENSBTAG00000020655" } ] } } ], "crossref": [ { "id": "Q3SX22", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020655", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020655", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505545", "url": "https://www.ncbi.nlm.nih.gov/gene/505545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCFLCWF", "url": "https://omabrowser.org/oma/group/TCFLCWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8E3", "url": "https://www.orthodb.org/?gene=A0A3Q1M8E3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIZ0", "url": "https://www.orthodb.org/?gene=A0A452DIZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SX22", "url": "https://www.orthodb.org/?gene=Q3SX22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16019:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16019:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001240651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8E3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8E3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8E3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIZ0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX22-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPGGDGAEDDVGAGIGPPAPGWCLRGRCRVGSQREDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQRDTACTIAATASVVKEKLTTEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 461, "header": "sp|Q3SX22-1|BSDC1_BOVIN Isoform 1 of BSD domain-containing protein 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=2 SV=1 CANONICAL=Q3SX22-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8E3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#A0A3Q1M8E3-1", "sequence": { "sequence": "MMEPGGDGAEDDVGAGIGPPAPGWCLRGRCRVGSQREDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQRDTACTIAATASVVKEKLTTEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 462, "header": "tr|A0A3Q1M8E3-1|A0A3Q1M8E3_BOVIN Computationally mapped isoform of BSD domain containing 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=4 SV=1 CANONICAL=Q3SX22-1" }, "locus": { "chromosome": "2", "start_pos": 121197929, "end_pos": 121176459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067186.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067186.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066383.1" } ] } }, { "isoform_ac": "A0A452DIZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#A0A452DIZ0-1", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQRDTACTIAATASVVKEKLTTEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 430, "header": "tr|A0A452DIZ0-1|A0A452DIZ0_BOVIN Computationally mapped isoform of BSD domain containing 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=4 SV=1 CANONICAL=Q3SX22-1" }, "locus": { "chromosome": "2", "start_pos": 121197929, "end_pos": 121176599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027526.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027526.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027526.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027526.4" } ] } }, { "isoform_ac": "A0AAA9SQA5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#A0AAA9SQA5-1", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQRDTACTIAATASVVKEKLTARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 374, "header": "tr|A0AAA9SQA5-1|A0AAA9SQA5_BOVIN Computationally mapped isoform of BSD domain containing 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=4 SV=1 CANONICAL=Q3SX22-1" }, "locus": { "chromosome": "2", "start_pos": 121197929, "end_pos": 121176599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126348.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126348.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087551.1" } ] } }, { "isoform_ac": "A0AAA9TYB3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#A0AAA9TYB3-1", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 335, "header": "tr|A0AAA9TYB3-1|A0AAA9TYB3_BOVIN Computationally mapped isoform of BSD domain containing 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=4 SV=1 CANONICAL=Q3SX22-1" }, "locus": { "chromosome": "2", "start_pos": 121197929, "end_pos": 121176599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132403.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132403.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103343.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103343.1" } ] } }, { "isoform_ac": "Q3SX22-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX22/entry#Q3SX22-1", "sequence": { "sequence": "MEPGGDGAEDDVGAGIGPPAPGWCLRGRCRVGSQREDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQRDTACTIAATASVVKEKLTTEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELAGVSPTSLKEAKVPVARPSTSPEGGPGPQSPCEENLVTPVEPPTEVTPSESSESVSLVTQIAKPPPASEAPALPKDLSQKLLEASLEEQDLAVDTGETGPPPRAQSKPHTPACRPSGPEPRPPARVETLREEILTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWD", "length": 461, "header": "sp|Q3SX22-1|BSDC1_BOVIN Isoform 1 of BSD domain-containing protein 1 OS=Bos taurus OX=9913 GN=BSDC1 PE=2 SV=1 CANONICAL=Q3SX22-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 306, "start_aa": "Thr", "end_pos": 306, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr306", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Ser123" }, { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Ser197" }, { "start_pos": 387, "end_pos": 387, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Thr387" }, { "start_pos": 418, "end_pos": 418, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Ser418" }, { "start_pos": 419, "end_pos": 419, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Ser419" }, { "start_pos": 449, "end_pos": 449, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "site_lbl": "Ser449" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505545", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RIT3-1", "protein_name": "BSD domain containing 1", "gene_name": "BSDC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEGEDAGWWRSWLQQSYQAVKEKSTEALEFMKRDLAEFTQVVQHDTACTIAATASVVKDRLARTEASGATEKVRKGISDFLGVISDTFAPSPDKTIDCDVITLMATPTGTTEPYDSAKARLYSLQSDPATYCNEPDGPAELLEAWLSRFSLEEKKGEIAELLATSPSIRALYTKMVPAAVSHSEFWQRYFYKVHRLEQDEVRREALKQRAEQSIHQEEPGWEEDEEEFLGMSPLPCANVKFPQAAEKASASAALEGSQPSVHKGPSGESWAILPPELAPAEGSPSESSESVSLVTQIANPASVPVVQLQTGVQPSGNRDLSQRLLEATSEEQSPLPKPPEPGHPSAAAQEPAVCSEQTAVTGPKEVESKAQGRTETLKEEGPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQLALSKVEVSGELEDEEWEDWE", "length": 451 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6AS17-1", "protein_name": "BSD domain containing 1", "gene_name": "Bsdc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGITVLDGRGREDVGWWRSWLQQSYQAVKEKSTEALEFMKRDLTEFTQVVQHDTACTIAATASVVKERLATEGSSGATEKVKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSRFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRADQSISEEPGWEEEEEELERIVPSPKEAKLPQETKTSTAPENEPAPQSPCEEIPVEAPAEATPSESSESISLATQIANPAAAPQPPELPKDLSQKLLEASLEEQSLAEDAGETGPPPPVTSKPLTPAGRASGLEPRPPARVETLREEVPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVEASGELEDVEWEDWE", "length": 434 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2BIJ3-1", "protein_name": "BSD domain-containing protein 1", "gene_name": "bsdc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADGEGGWWGGWLTQSFQSVKDKSAEAYEFIKRDLTEFSSVVQHDTACSVVATANAIKSKLAVEGSSETTEKVKKGITNILGVITDTLAPPPDKTIDCDVITLVATPTGTTEVYDSGKARLYSLQADPATYCNEPDGPPQQFDSWLSTFSLEERKAEISELLVSSPAIRALYTKMVPAAVAHAEFWQRYFYKVFQLEQEEARRVALKQRAEQTDHSESLGWEEEDEEGEFLGATSLSRLDFTPPVEESRVPAVTVADTPESSSPPQAVASLSNVASDVTPSVSSDSVSFPTQIENQAESVTIRVTQPSPAADELSQKLSDTGLQETFPEERPAPREETAREDMAQDLRVFELNSDSGKSTPSNNGKKGSSTDVSEDWEKDFDLDMTEEEVQMALSKVDATEELEDEDWENWE", "length": 412 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H940-1", "protein_name": "BSD domain-containing protein 1 isoform X1", "gene_name": "Bsdc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKSTEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLATEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRADQSISEEPRWEEEEEELEGIAPSPKDVKIPKETKTSTSPEDGPGPQSPCEDTPVEPPAEVTPSESSESISLMTQIANPATAPEAPVLPKDLSQKLLEASLEEQSLAEDEGETGPPPPVPSKPLTPAGRASGPDPRPPARVETLREEVPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASDELEDAEWEDWE", "length": 427 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q80Y55-1", "protein_name": "BSD domain-containing protein 1", "gene_name": "Bsdc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKSTEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLATEGSSGATEKVKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSEFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRADQSISEEPGWEEEEEELEGIVPSPKEAKIPKETKTTTSPEDEPAPQSPCEETPVEPPAEATPSESSESISLVTQVANPAAAPEAPELPKDLSQKLFEASLEEQSLAEDEGETGPPPPPPSKPLTPAGRASGPEPRPPARVETLREEVPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWE", "length": 427 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NW68-1", "protein_name": "BSD domain-containing protein 1", "gene_name": "BSDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLATEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELMGISPISPKEAKVPVAKISTFPEGEPGPQSPCEENLVTSVEPPAEVTPSESSESISLVTQIANPATAPEARVLPKDLSQKLLEASLEEQGLAVDVGETGPSPPIHSKPLTPAGHTGGPEPRPPARVETLREEAPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWE", "length": 430 }, "evidence": [ { "id": "Q3SX22", "url": "https://omabrowser.org/oma/group/Q3SX22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q3SX22", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 461, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX22" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX22" }, { "id": "PRU00036", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00036" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BSD", "eco_id": "ECO_0000255", "start_pos": 177, "end_pos": 229, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 306 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 123, 197, 387, 418, 419, 449 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX46-1", "uniprot_ac": "Q3SX46", "uniprot_id": "C1GLC_BOVIN", "mass": { "chemical_mass": 36441.0, "monoisotopic_mass": 36441.0 }, "refseq": { "ac": "NP_001029747", "name": "C1GALT1-specific chaperone 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029747" }, "gene_names": [ { "name": "C1GALT1C1", "type": "recommended", "evidence": [ { "id": "Q3SX46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX46" } ] }, { "name": "C1GALT1C1", "type": "synonym", "evidence": [ { "id": "NP_001029747", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029747" } ] } ], "protein_names": [ { "name": "C1GALT1-specific chaperone 1", "type": "recommended", "evidence": [ { "id": "Q3SX46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX46/entry#names_and_taxonomy" } ] }, { "name": "C1GALT1-specific chaperone 1", "type": "synonym", "evidence": [ { "id": "NP_001029747", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029747" } ] } ], "function": [ { "annotation": "Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX46", "url": "https://www.uniprot.org/uniprotkb/Q3SX46#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX46", "url": "https://www.uniprot.org/uniprotkb/Q3SX46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1GALT1C1", "url": "https://www.uniprot.org/uniprotkb/Q3SX46", "locus": { "chromosome": "X", "start_pos": 5170113, "end_pos": 5176087, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021410", "url": "https://www.ensembl.org/id/ENSBTAG00000021410" } ] } } ], "crossref": [ { "id": "Q3SX46", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021410", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021410", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531644", "url": "https://www.ncbi.nlm.nih.gov/gene/531644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVMMRKA", "url": "https://omabrowser.org/oma/group/WVMMRKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX46", "url": "https://www.orthodb.org/?gene=Q3SX46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23033:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23033:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029747", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SX46", "url": "https://www.uniprot.org/uniprotkb/Q3SX46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX46-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGSRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCILLVRPKDVSLWAAVKETWTNHCDKVDFFSSENVKVFESINMETNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSMEGGIVLSIESMKRLNSLLSIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDSEGKDIFNTKSVGLFIKEAMTNHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSDND", "length": 318, "header": "sp|Q3SX46-1|C1GLC_BOVIN Isoform 1 of C1GALT1-specific chaperone 1 OS=Bos taurus OX=9913 GN=C1GALT1C1 PE=2 SV=1 CANONICAL=Q3SX46-1" }, "isoforms": [ { "isoform_ac": "Q3SX46-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX46/entry#Q3SX46-1", "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGSRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCILLVRPKDVSLWAAVKETWTNHCDKVDFFSSENVKVFESINMETNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSMEGGIVLSIESMKRLNSLLSIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDSEGKDIFNTKSVGLFIKEAMTNHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSDND", "length": 318, "header": "sp|Q3SX46-1|C1GLC_BOVIN Isoform 1 of C1GALT1-specific chaperone 1 OS=Bos taurus OX=9913 GN=C1GALT1C1 PE=2 SV=1 CANONICAL=Q3SX46-1" }, "locus": { "chromosome": "X", "start_pos": 5173240, "end_pos": 5172287, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028542.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028542.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028542.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028542.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531644", "resource": "KEGG Pathway" }, { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7K2E2-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1galt1c1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEIEYLFNLKSFVMARGKMLSESSSFLKGVMLGSIFYALITTLGHIRIGHRNRTHHHEHHHLQAPNKEDISKISAAERMELSKSFRVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINVDTDDMWLMMRKAYKYAFDKYKEQYNWFFLARPSTFAVIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNSLLSVPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADRKDVFNTKSVGLFIKEAMSNHPNQVVEGCCSNMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSDND", "length": 336 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BSH4-1", "protein_name": "C1GALT1 specific chaperone 1", "gene_name": "C1GALT1C1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSESSSFMKGVLLGGIFCVVVTLLGHVKIGHGTRAHHHEHHHIQAPNKEEVLNLSEDEQLELSQSIRVYCIVLVKPKDIGHWAAVKETWSKHCDKAEFYSSEDVKVFNAVVLNTNDMWTMMRKAYKITYERYKDEFNWFFLAYPTTFAIIENLKYFLLKKDPAQPFYIGHTMKSGDLEYVDGEGGIVLSIESLRRLSHVFEDSDKCPEQGGMIWKLSEDKQLAVCLKYTGVIAENAEDSEGKDVFNTKSVNALIKEAMASRPEQVVDGCCSDMAITFNGLSPNHMHVMMYGVYRLRPYGHTYSDALVFLPPAGSDND", "length": 318 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FBK8-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "c1galt1c1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMSEGSSFMKGMIFGGIFCLIMSFFETFNPGTHSEGHNHLHHHLKPVSKDELQKLSESQMSEFAMQVRVYCLIMVTPKLLVHWATANDTWSKHCDKSVFYTSEASKALDAVDLQEQDEWTRLRKAIQHAYENAGDLHWFFIARPTTFAIIENLKYLVLDKDPSQPFYIGHTEKSGELDYVEYDSGIVLSYEAMRRLMEVFKDEDKCPERGRALWKMSEEKQLATCLKYSGVFAENGEDAQGKGLFNKKSVSSLISDSISQNPGDVVEACCSDMAITFAGMSPSQIQVLMYGVYRLRPYGHDFHDSLTFLPPKDSDND", "length": 317 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RUC2-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITTLGHIRIFHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFQVYCIILVKPKDVSLWAAVKETWTKHCDQAEFFSSENVKVFESINMETNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSVEGGIVLSIESMKRLNSLLDIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDAEGKDVFNTKSVGLFIKEAMTNHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFSDALIFLPPNGSDND", "length": 318 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q499P3-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1galt1c1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITMLGHIRIGNRMHHHEHHHLQAPNKDDILKISETERMELSKSFQVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAYDKYKDQYNWFFLARPTTFAVIENLKYFLLRKDPSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNGLLSVPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLFIKEAMTNQPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSEND", "length": 316 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96EU7-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1GALT1C1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND", "length": 318 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JMG2-1", "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1galt1c1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSESSSFLKGVMLGSIFCALITMLGHIRIGNRMHHHEHHHLQAPNKDDISKISEAERMELSKSFRVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAYDQYRDQYNWFFLARPTTFAVIENLKYFLLKKDQSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNSLLSVPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLFIKEAMTNQPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSEND", "length": 316 }, "evidence": [ { "id": "Q3SX46", "url": "https://omabrowser.org/oma/group/Q3SX46/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SX46", "url": "https://www.uniprot.org/uniprotkb/Q3SX46" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "Q3SX46", "url": "https://www.uniprot.org/uniprotkb/Q3SX46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX46-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 318, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX46-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX46" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00027JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00031MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00032MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00033MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00063MO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00069YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00079IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00094SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00139WK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00164QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00196CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00238CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00241VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00287UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00318OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00372ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00376RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00394CR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00423TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00428HK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00430ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00464AQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00467QU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00468NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00496OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00560KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00653TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00675GF", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G00682IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00707RC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00728SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00729SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00754TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00789VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00803TF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00872ZT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00891GP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00897BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00907IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00932UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00944OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00952LS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00967VH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00978GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00979XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00980BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01040ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01116MS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01155GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01287FH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01302LF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01316HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01357LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01362WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01376HR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01450RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01453BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01464ES", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01471GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01520KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01532FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01534TU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01546PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01577DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01584VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01608UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01614ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01625GQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01643LM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01657UH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01666SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01674VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01682LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01707KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01759NM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01763RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01769GP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01802HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01879FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01912GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01923FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01999VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02020YO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02078ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02127XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02150AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02161CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02288EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02289NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02297WO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G02353KU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02377RY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02379AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02393LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02402NL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02403ZU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02442MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02530VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02539TH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02594WS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02613LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02642GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02684WR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02729OV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02799CL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02844SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02873KW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02912JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02942YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02990AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03003KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03018QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03024EJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03035VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03049NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03129RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03140AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03168RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03200OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03266UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03278MV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03304QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03325JN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03339IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03412UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03425VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03433NI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03438WE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03462LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03505EQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03549GS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03574EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03603IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03605AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03644PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03670RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03714XC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03720YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03796EF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03819IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03825XC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03840OO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03847RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03852KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03900NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03916DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03941EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03975EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03989SP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04014AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04016KC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04043RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04062VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04074KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04088QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04091CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04114CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04116CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04130SK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04137HF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04185QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04267XF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04289KQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04298QC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04324CR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04337AE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04352JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04402ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04421LE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04422XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04428BJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04450CG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04459VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04478DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04483QG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04490OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04505IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04513DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04522ZB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04527KW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04531ET", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04534UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04536JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04540PY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04564SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04608YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04638IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04653HU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04712IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04734LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04737UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04760XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04765GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04842IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04949CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05028TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05106AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05180BW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05183GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05187DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05234QD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05252QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05259MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05278GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05324AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05374TU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05380VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05384EB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G05400IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05402FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05410WY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05411CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05413EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05428SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05456PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05490PJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05543BI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05562YT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05573WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05597SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05620JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05620VJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05633TS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05644LC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05665LK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05670VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05690OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05724WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05774PX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05784LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05784QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05785JJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05835TV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G05848DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05882RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05918XD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05994BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06067PC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06087NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06149AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06225LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06240OP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06317RG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06341YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06342XU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06366AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06404BM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06408QU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06448OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06449JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06453RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06460LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06503AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06507BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06523WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06558RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06563KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06577DG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06593KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06654RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06661NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06662ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06676BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06755AP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06783AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06786CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06864JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06938KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06963BI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06967GN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G06990BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07061BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07061YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07078LK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07099ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07141OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07164WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07191NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07281UF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07293JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07405CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07430HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07435LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07443RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07479EG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07480TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07578MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07610JY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07676GT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07677VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07680WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07692KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07695IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07764JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07779GP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07789RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07819HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07869UA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07898UR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07904XW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07937GC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07982LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08016YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08033FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08046LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08055MG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08115PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08131WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08140FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08201TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08201TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08244KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08244YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08264JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08267YC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08306FC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08308ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08358DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08366OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08382XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08425VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08426DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08465VN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08516DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08566CQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08569VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08660AA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08670DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08700OQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08715FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08772WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08784DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08807HM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08892TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08941LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09079WY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09108HO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09125MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09130SS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09139MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09147XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09153LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09154YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09185DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09207SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09224US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09226UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09287HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09403AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09425PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09441VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09480OP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09583DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09640VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09678FF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09781FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09845DR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09859LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09921KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09938IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09941BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09980KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10023KT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10082ZS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10119AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10148CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10180QX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10204GU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10225UW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10287KB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10290UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10325PN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10343DO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G10372YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10408DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10487BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10514PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10581YA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10604KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10608NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10643IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10679DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10698NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10705PR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10706IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10768ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10816YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10818TP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10831FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10859BP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G10925II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10954DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11061VC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11078XZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11083DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11091XO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11105TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11120EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11198HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11201QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11253PI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11259WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11263YZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11272SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11343WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11350ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11366PY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11373TT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11377IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11411KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11427UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11457RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11466IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11679KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11699WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11737JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11778HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11795BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11819NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11827HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11846US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11848VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11863CH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11876US", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G11889PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11905CY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G11907PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11936KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11940TK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11980DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11985MT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G12019PJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G12032IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12040RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12111NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12133SZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12190QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12193VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12230UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12232OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12350CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12365RQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12389NM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12396GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12405JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12428MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12455XO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12525VG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12526XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12541EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12548MD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12573LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12573WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12604MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12616PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12619FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12680ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12697UE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12720KS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12761QA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12850TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12891KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12900GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12902SM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G13089IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13101AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13104VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13168IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13179FD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13204HV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13205MF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13251BD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13258AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13260JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13292XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13346PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13477DY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13483MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13496UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13500IP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13511YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13610SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13616KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13625HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13684QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13695SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13761UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13764RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13767YY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13782XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13785BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13813GW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13814UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13816ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13858YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13863XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13890JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13894RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13934YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13968BO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G13976VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14009XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14014EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14125ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14130OH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G14133PN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G14138XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14188TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14205YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14238UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14250HG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14259XA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14296RM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14303LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14346JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14375KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14392HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14442NU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14446LS", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G14453LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14514DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14533ZS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14567YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14623FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14646AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14676JD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14693JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14722QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14781HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14812IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14868UU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14919CV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14955CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14965PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14997LZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15003XX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15011KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15023FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15033WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15050SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15099DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15173TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15178AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15220QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15249CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15446MA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15484AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15555MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15618NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15626ED", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15631KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15633AT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15635CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15718TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15756SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15772KA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15779LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15794WJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15849KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15870AR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15876HU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15882EZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16040ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16078YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16079QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16268BN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16327YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16344NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16365JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16370GQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16438UK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16440EL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16458JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16503YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16536QD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G16568AK", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G16576OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16598VU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16607CP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16609LV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16617HJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16682CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16706SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16709FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16739XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16768QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16827DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16867VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16943AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16964KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16970LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16975LY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16982ND", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16984QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17024OR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G17039UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17039ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17041QN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17050CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17055DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17096JA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17100VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17126MK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17133RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17218WW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17241OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17269LY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17280PS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17294JY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17300DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17320JG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17326TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17331IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17331WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17346NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17350RY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17361GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17401LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17454VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17456TE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17457PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17465GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17480GI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17488LP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17527HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17667YX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17673XH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17700LK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G17709UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17733ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17740TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17743FY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17752YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17758YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17766PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17866PG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18067AF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18078JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18117YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18132YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18174LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18214MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18299YA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18347PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18362VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18405WX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18427DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18472TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18516CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18519LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18559LN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G18559VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18561AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18603ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18653BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18695QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18702SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18734SR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18755YY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18800AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18815VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18841NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18853HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18855WX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G18871OL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18890KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18924BG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18930SC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18932FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18946TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18950NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18953GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18963DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18980PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18982QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19002DQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19029ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19043KB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19114BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19122BQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19135OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19203SG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G19238ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19283CF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19342EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19382GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19454WY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19474IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19555CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19562CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19596BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19664QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19722GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19756XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19793PI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19793TF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19807JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19813SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19933AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20016GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20038KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20043VW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20059NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20061RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20064ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20164HH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20210OT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20222KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20251UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20310DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20359JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20435PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20440GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20482JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20557GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20566UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20718YD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20735IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20739VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20745AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20752RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20826OM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20828MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20854YP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20860NB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20867OR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20878US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20879UO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G20884IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20890FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20988ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20993TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21147BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21202EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21217SF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21227CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21297DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21360BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21373SZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21384RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21385AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21507RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21564HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21573GX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21586NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21654MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21672LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21675EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21696DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21755QG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21780GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21827YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21845NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21859TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21877OB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21880FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21905ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21931BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21939VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21939WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21989SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22070LE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22222BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22302YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22327AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22343QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22366MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22498IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22540KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22564NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22609VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22611UR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22733YM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22773YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22782LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22787WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22793FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22815DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22841DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22849VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22852AR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22903MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22970UG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22976NF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22988HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22995SW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G23006CO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23016AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23021IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23048PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23066SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23068ZB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23082UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23113ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23119MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23126IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23193CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23202WP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23252EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23262BU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23262LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23285KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23314QX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23348CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23355WV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23404PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23416ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23425OX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23463KX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23494UZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23502AY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23532MP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23560WQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23580VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23633EE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23674BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23801QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23866EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23888EZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23893ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23975EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23979XZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23999MD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24055UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24120OI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24142JB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24146VR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24151NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24186OV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24218RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24256XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24293BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24296ZA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24296ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24303LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24327KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24363HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24366RG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24371IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24407ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24475OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24508MA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24516WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24525ZJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24548HS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24553WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24569EC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24646NC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24646WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24684JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24720OO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24739SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24768CX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24790YU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24820LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24856YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24862OS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24882EK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24931MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24951IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24970IL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25006JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25040JY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25043OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25061TS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25064SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25065CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25127JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25146DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25153GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25213RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25322NY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25323VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25351JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25380IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25382RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25416CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25436EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25439DD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25443TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25489WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25499LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25529RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25538MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25571LJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25612EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25705WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25716MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25726HS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25733QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25764DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25776XU", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G25778VW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25795DA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25804XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25848FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25865TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25895SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25934VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25935VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25937FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25977RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26021BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26121MN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26176JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26185YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26209TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26224UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26228QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26229QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26301NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26325AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26326PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26341AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26341TZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26392IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26427QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26429CZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26441FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26472EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26493RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26570RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26629OM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G26651YZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26688CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26700PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26702BZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26712CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26725PG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26754XS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26778RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26806EA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26827ST", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26885DO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26913JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26918XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27000YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27071PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27092AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27192WV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27236KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27248RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27326AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27366LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27384IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27400ON", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G27409LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27499KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27520PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27523II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27562JG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27603XJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27605DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27655DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27721RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27796IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27817KG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G27866VO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27868TR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27883TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27893KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27967WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28010TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28023AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28040SC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28077AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28085OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28116PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28132XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28136FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28200CZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28326EU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28329XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28336ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28371PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28378XH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28384MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28465GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28546UC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28561QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28598IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28665FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28694FA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28749YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28750LN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28757BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28801XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28806OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28856KD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28877HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28878FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28881KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28885XK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28886HO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28915JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28989XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29014XV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29098XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29144HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29181KK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29231AT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29260RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29290QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29326OK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29348FH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29386CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29404FC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29418HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29477YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29489PN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29495CE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29539ZA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29546CR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29622NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29624ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29628MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29644TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29667VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29725MK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29818FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29879FQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29914BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29940LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29956GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29971IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30011VO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30086CM", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G30090IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30110UW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30120XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30147IW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30182VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30211JD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30232EU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30255XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30284BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30304DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30365BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30367NE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30372CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30391YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30392XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30425ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30434QC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30443NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30464XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30584YH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30590EC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30591GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30609WQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30614QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30647NK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30651QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30673NA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30736BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30739AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30743FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30832XJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30835JV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30853JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30871VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30872GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30897RJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30933VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31073HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31087MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31101EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31118TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31161GA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31208LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31248ZH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G31288FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31335UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31372TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31457ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31540HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31565JD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G31601FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31676DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31686QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31729QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31776ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31846AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31884XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31894FR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31997DH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G32026LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32112SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32167RW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32216IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32289FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32306SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32333NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32426JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32460TA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32541GR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32588AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32590UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32652KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32660EU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32735YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32853SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32863IR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32877EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32910OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32948PW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32968SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33012HL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33018IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33024FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33064PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33101CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33115WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33159AG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33236UO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33278DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33286MK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33287EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33345BX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33350QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33350UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33368AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33377US", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33401IN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33403VX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33418YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33463NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33479HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33508VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33569OU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33610ZO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33633KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33652MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33658KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33669VL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33696UB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33719VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33758XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33772BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33840DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33841YH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33858ZT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33860PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33886DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33892UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33899KJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33908QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33911NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33961NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34041VO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34049BA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34068FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34096TA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34100DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34123VN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34143CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34162ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34168KI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34180FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34219XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34293SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34336BJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G34449IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34479QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34539VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34592BE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G34705QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34706DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34764BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34824ZD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34854XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34891MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34893KL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34918NO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34962LY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35039IM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35110VT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35127VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35199BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35234CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35238UK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35243PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35252UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35301YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35312VR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35316IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35338HV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35343OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35369GY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35409SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35419IZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35432EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35437KG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35451HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35486FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35528EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35551AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35632SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35656YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35679QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35718GY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35745YL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35750SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35778AN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35799DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35805TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35825BV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35842UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35866KN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35891AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35898DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35900GR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35932XK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35941VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35946GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35947YD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35949CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35977FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36039YA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36046VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36047BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36094GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36138ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36157LL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36171FU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36184OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36185XU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36231CI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36258NK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36359GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36381SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36406GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36410YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36443XA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36460YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36479RD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36480VP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36482YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36502OW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36511AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36588NK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36674QY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36761DZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36774NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36786TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36793ZF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36835IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36839GD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36855EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36856ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36958OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36970ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36983SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37003XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37043BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37093SO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37115PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37134CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37137WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37190OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37222EI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37231JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37239FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37241GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37282LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37283DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37297IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37325HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37354FL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37381UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37416IR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37435GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37510PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37528JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37597VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37638KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37649DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37653KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37716XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37779JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37801HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37843CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37861OJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37885HZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37891WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38002BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38004LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38027UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38065TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38075PP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38078TR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38207GT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38229RW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38234JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38296RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38316MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38335CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38361SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38418FR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G38462TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38465NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38468XG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38506CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38542FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38568EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38616ID", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G38688TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38702PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38722VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38754AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38773BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38799GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38802WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38812YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38823IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38877IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38887TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38975ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38979WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39011WZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39037TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39053QM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39098FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39120NF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39135DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39136MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39147LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39162CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39205FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39246KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39260NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39283IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39305NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39393JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39422JF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39423SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39496AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39516UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39523KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39558MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39611QP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39615UL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39632AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39650IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39676NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39720OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39742GX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G39759RL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39762RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39802SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39815IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39865FQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39890DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39916NT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G39948NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40069TO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40088CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40107NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40119MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40269CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40289VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40294ED", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40319SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40338WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40347YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40393FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40397HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40445LE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40455IF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40468XE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40539YV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40560HO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40565CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40580KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40606LI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40660XA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40681EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40706KD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40737YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40792HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40799GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40813RE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40825DC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40834NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40838GB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G40852TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40957MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40963HH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40979HK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41037IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41165PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41196CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41220ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41245OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41255BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41257VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41321IO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41322DV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41324RH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41330YY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41358UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41403QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41424HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41434QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41444DX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41451JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41498BE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41539MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41540NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41545LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41552DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41552FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41570ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41606JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41732ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41780OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41797KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41816PJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41834QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41836YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41866GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41896LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41919TD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41928NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41964LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42002WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42039AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42051BB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G42065BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42089IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42105TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42120JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42154JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42206TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42239OO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42245KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42300CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42325VD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42368XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42388XF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42393CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42398CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42407QV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G42448YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42468DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42545LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42603RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42611JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42622BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42632OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42665KV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42668PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42750RV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42752PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42772WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42797SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42814RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42828SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42829MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42829WM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42883ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42908EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42927HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42929BO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G42993UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43001RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43025II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43027VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43039PK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43059PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43079BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43145UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43146HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43204BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43220WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43438SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43449ON", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43453MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43506AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43514NA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43572AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43592AC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43619YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43629KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43636EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43639BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43656YN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43662XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43668RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43744JB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G43766HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43825VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43875XT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G43925AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43933MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43972TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44127LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44199IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44236OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44244JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44342ZF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44374JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44397RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44409MI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44414IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44463UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44495BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44504WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44543KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44551BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44597NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44848OP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44886WZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44900DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44917UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44980KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45003LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45047PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45086UC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45089UO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45095CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45129XM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45219EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45235OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45291XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45304AE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45313PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45333LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45333UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45335XP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45367LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45388VA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45402WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45465HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45563VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45579IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45592JO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45596OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45699QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45707SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45709SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45718WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45756EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45767XH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45819SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45911EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45917UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45941OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46026IB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G46029TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46039GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46088YW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G46168RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46174KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46222DM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46241WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46304CE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46320BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46340EI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46341RW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46382BV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46420ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46500XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46501AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46503UI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G46520QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46532VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46609ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46627WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46681XX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46748BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46754UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46758LT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46760LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46785SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46822ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46868TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46915JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46926OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46935AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46960TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46974QL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47174QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47180UC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47190LU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47307MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47325XO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47360UL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G47370LX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47391NN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47452EQ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G47483HJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47519RD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47522FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47537XW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47538PA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47560LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47573PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47590GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47652ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47669CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47690ND", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47709SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47772RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47818EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47867DI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47935HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47952MI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47975LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48089QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48115DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48129FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48235SJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48256FI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48265KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48265YT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48321FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48355MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48365EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48367IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48367ZH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48499NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48503ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48533PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48585WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48678VC", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G48759RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48768RT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48785BB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48789OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48791KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48809BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48809VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48822HK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48823WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48854JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48972NU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49029NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49088AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49104WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49120XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49194KA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49197SK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49221CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49302PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49327HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49332RT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49349BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49370IN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49394FL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49418IP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49426SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49437KN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49460YF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49464XD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G49465QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49485GD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49499SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49520ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49527BY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49529DV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49567XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49582PC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49603LL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49604IR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49609ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49671FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49721KD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49763BM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49773DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49844LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49854OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49944DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50001GD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50003EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50003FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50071OA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50076EU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50077VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50117DJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50165MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50178BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50215WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50223FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50252SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50254UQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50303VE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50362JF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50425IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50562TV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G50574FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50587UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50613GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50617EZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50652EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50685MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50690RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50709IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50755IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50762OP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50769VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50805QB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50808YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50809LR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50849OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50896EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50905UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50937OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50970GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50977JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50999TP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51005JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51018LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51020FB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51071LC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51091HB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51103QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51114IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51116JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51157XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51192NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51216AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51316WJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51318YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51349BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51394GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51473GI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51500KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51502JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51509AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51554PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51557QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51566FN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51586EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51678TA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51709UX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51722JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51726CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51747SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51774AT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51809TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51840MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51842SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51883EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51891WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51914CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51914HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51947OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51992CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51993UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52070NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52071EY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G52120GQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52120NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52144RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52154FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52179YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52188XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52217QW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52232VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52236XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52244NI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52262VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52316LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52318OF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52376IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52380IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52447UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52471BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52515QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52639VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52652AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52738OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52794ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52916PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52937XP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G52953EP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52971SZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52972TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53000BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53016WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53023PP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53064IK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53066XA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53084MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53084TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53151WW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53180NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53188WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53219BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53220ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53225BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53246IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53251NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53303ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53330OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53404LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53435KM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53440PM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53472RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53490OS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53498KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53502ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53522BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53527TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53535QW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53682MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53737KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53778MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53809VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53827VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53834TX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53856PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53864RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53922OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53931RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53933PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54029EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54060QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54083SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54121EO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54125VH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54163UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54190AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54199ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54212AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54264AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54286RT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54370PI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54371SF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54392HP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54394ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54409FD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54410JV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54426UX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54439SD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54451EW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54461SS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54542VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54650UF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54651DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54706BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54727BI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54745KD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G54760IB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54795GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54802EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54847BG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54847JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54896JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54938LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55006MX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G55019GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55025YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55037II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55043JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55051BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55055JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55152EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55174HS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55205VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55223IP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55259BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55282VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55331YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55398ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55407TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55459MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55464VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55480NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55492KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55529NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55567ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55592QU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55636WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55638XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55664FE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55695AY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55700PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55753QM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55866KK", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G55870EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55880FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55967EP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56042JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56067ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56077PT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56111FM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56186MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56194FV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56200PW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56245IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56299XO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56404GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56418NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56427WT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56498UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56506GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56575BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56682BC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56734EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56803IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56882GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56936OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56946CM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56947WF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56961QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56973FQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56979BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57007FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57030TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57046HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57068ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57092PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57144YM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57184TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57249PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57276IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57296XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57385MA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57415BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57482YT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57505PZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57510LQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57545VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57558XS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57568CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57672ST", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57692HM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57734UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57772TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57803ND", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57832UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57836JM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57840ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57857CB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57872KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57925NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57949TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57971KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57993RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58066JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58078TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58106KY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58145JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58181OH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58195CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58201OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58272ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58276QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58325KK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58362DI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58386YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58414HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58450MK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58473ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58486ZT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58489WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58489YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58501OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58511VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58539KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58577QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58582XO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58620PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58645HA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58683GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58695FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58697JA", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G58699ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58776MY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58793GF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58806SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58810QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58814JC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58815WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58846EV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58878NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58952ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58972RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58980RJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59035KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59103LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59155GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59212FY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59332RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59379KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59417ID", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G59432AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59498PG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59588ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59595AB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59658KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59740UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59745LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59746EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59757WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59821JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59853RL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59930AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59944EN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59969VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59970QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59973RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59999BN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60067UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60138JZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60231EF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60234BX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60341PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60403CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60426XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60437DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60457MA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60461BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60558WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60598XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60603HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60615ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60729FR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G60731ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60734PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60740GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60755CL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60799ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60844ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60883HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60884FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60890ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60925RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61072JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61089HL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61094XY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61119KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61159LY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61176JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61238HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61311ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61341GD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61358KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61411XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61459KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61501FW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61582HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61747RH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61757FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61780GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61788PW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61886WA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61887VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61972DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62001NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62014UA", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G62014YU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62015ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62044IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62044ND", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62055DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62070TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62146JX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62189UN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62217NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62218ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62221RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62252OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62274IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62278MB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62311FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62382LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62414VY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62469XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62471ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62574YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62577TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62613QD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62621XS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62680DG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62680UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62713BK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62741IO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62765JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62820PI", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G62824TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62861MP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62980KY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G63020KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63110FE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63161GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63188OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63193BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63194GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63209WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63231BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63242HY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63258OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63309YY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63324SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63342TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63343WQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63349JM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63377SE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63404EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63405JW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63416WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63438EB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63443GA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63474NY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63505HS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63527PL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63550TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63570GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63628UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63660JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63664GB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G63716UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63717SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63727WO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63748AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63754TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63787FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63794QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63826DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63858YS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63932ZM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63978FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64002SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64029DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64050LH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64055WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64165TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64206XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64239KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64242OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64285PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64305XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64354IV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64458EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64476AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64485VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64527IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64560HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64563CQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64566OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64575OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64604UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64610UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64712UU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64774WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64839PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64851ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64852XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64899EB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G64904FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64904QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64937TE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64973KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64981YW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64996BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65037OI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65085NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65124UZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65135MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65191ST", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65200OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65225VD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65237AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65249DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65262KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65285QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65321RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65345RD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65347HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65351EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65363PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65364FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65365ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65369IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65376QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65396UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65447BW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65464AD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65549NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65562ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65600KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65602FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65609NG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65660BL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65667PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65669BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65704VY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65715DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65728QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65777NT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65796KU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65800DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65805JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65809MG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65837AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65867LM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65895VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65909WP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65955VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65978JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66030KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66040YD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66055IE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66160FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66166BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66188DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66191UP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66213WH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66253BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66284CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66289YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66301VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66349AX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66360FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66405LD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66414OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66419SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66421OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66435SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66489LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66505YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66512FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66552NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66576RC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66651WU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66654PP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66662KA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66669IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66685LA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66711OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66741QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66828DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66838AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66858BS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66867PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66872WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66887YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66959DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66967KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67053LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67263AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67274NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67281LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67306YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67326LW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67371HE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67384JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67384KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67407NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67451GS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67471ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67561OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67586UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67590LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67650WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67682CC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67686RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67693JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67695RM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67775HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67796SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67797LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67821CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67878YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67883AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67920QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67935MX", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G67959IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67969CT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68008QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68133RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68175FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68190BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68200GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68207KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68210RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68232HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68264WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68286QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68310FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68384KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68391RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68412PR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G68458SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68480EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68529LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68563JG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68614NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68636XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68672OT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68686HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68713BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68733PD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68776NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68820TX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68893BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68894XH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68924IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68951DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68956JQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68964XC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68986CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68990TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69022KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69033GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69093SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69096ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69118GP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69137GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69176ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69185XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69261IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69281GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69288VJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69327YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69420JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69440CJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69443HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69445ZX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69446XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69479TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69500TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69616MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69627IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69631DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69685RI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69723CB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69735UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69748TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69762CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69765IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69774ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69788BR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69808IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69824GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69831AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69876CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69890SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69969LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70074GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70080NT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70081ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70097NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70122ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70125XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70146PH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70186NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70228DF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70332AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70422TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70444FA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70520NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70539LS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70568SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70572KM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70579MZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70582LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70623QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70631UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70647PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70648DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70651ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70658PP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70688TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70693FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70783BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70815NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70919RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70928KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71057CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71077LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71089OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71091AL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71094KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71121NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71133TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71139HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71174VV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71202JE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71229DV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71234WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71247WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71249CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71283AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71306LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71307CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71362YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71455DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71479KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71487ZS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71502EE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71506JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71520GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71528GY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71538OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71549TN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71575PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71620LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71680KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71695GL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71707QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71713QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71719NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71725KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71767XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71773FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71832QJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71835SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71953WK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71964JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71969OB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71989CT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71994UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71999UY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72008IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72070EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72130HX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72175XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72261BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72263DG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72279PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72287LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72289FX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G72298WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G72303HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72319HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72319UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72336LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72379PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72446TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72526DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72620YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72647JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72647WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72673RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72693SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72729HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72735TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72790LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72827OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72830DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72914LC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72992IV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73019DE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73033IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73076IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73184QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73203OQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73209SM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73323VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73328UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73344QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73351YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73373AY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73382HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73440TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73481KW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73487DJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73507OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73522II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73544PN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G73574DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73609FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73653TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73663RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73678DS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73723ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73760YR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73829NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74012IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74038AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74049SP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74084GS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74179EL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74225AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74241QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74252EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74286WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74294TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74340SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74396CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74410JX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74426IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74463NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74471QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74473MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74484ON", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74489AS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74491LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74503BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74542HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74603OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74607VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74678FD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G74684ZW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74701OU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74702CZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74758HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74782FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74814JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74855JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74855SC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74917JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74918VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74941GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74945NC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74950DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74975UG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75032PM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75039PU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75042KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75120QY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75121VU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75168BA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75171WW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75178DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75212LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75242PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75339KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75376YT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75389LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75407RU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75408KS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75453GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75472OU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75480QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75483WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75549SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75584YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75586OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75594JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75599HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75621PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75637RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75646NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75648IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75687SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75701WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75704MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75709RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75717AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75726JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75749JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75786FQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75851ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75905JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75924IA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75936VJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75975LI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75999PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76031FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76082SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76104SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76200OU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76214JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76247UK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76299ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76387IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76389HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76420FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76459ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76465IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76470HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76500NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76505ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76561LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76603DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76607YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76703CC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76726PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76748ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76789KR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76863NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76876LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76881UY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76910CD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76997PL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77076CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77095CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77109JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77136XW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77149IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77213YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77311AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77395DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77477NL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77481LZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77497MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77503IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77535NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77550KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77557JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77627AJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77633IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77674IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77696IB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77740PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77937PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77938VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77945NE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78011OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78034SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78056MI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78104ML", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78127DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78156NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78202HA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78239OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78262KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78293EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78315FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78369LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78372JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78436BB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78475DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78482II", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G78482IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78519JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78617GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78657XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78695ET", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78729FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78734OE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78744AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78757VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78768PN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78783JO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78788QJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78789AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78792AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78830IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78856SO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78880TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78918BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78928PU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78990OC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78992FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79011EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79019WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79021WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79035QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79083TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79137TM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79168SD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79222ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79224KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79243QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79246GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79464QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79492YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79566BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79745IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79762CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79763SM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79788QE", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G79828LU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79855KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79878OX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G79889QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79968EZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79976GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80027ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80147HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80188JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80204VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80251DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80288AX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80306SV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80308BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80316IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80343TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80346ZU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80403NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80418BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80428YE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80434TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80565QS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80577OW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80643JD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80667HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80700YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80719YH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80726UW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G80738BU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80738PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80903UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80903ZD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80951VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80960YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81013HU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81041HS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81096BD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81167HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81213GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81214EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81303NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81439BR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81466NG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81473HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81520BE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81541IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81632WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81680BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81748GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81778DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81797TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81825YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81832CY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81832XS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81944UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82028JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82054AK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82092PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82133EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82152YZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82155DA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82195SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82216JH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82251ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82264VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82267MT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82286VD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82324DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82334OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82362HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82363EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82366DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82370DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82393KC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82412EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82427FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82469TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82512PT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82621TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82638QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82680KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82693QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82714WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82737ZO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82785ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82870SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82881HF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82882LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82905PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82906DM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82947ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82950HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82952OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83029ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83068AX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83080DP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G83092KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83103PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83104JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83134ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83192EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83206CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83232LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83244OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83261UB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83362WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83364CQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83412BV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G83412LT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83432YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83434MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83476KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83479LG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83491LR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83495JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83514WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83517DN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83519QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83580CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83620XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83697JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83700KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83719UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83754KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83808HF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83831AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83843GL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83920DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83950JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83998HE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G84010XP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G84064VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84071MB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84122DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84146JE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G84168WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84184XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84205RB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84228OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84264WM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84273UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84285WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84332AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84366AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84398ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84504MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84515GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84532IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84559PU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84571QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84596RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84818UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84821OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84827GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84853WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84906AJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84906ML", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84969LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85002XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85020KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85049LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85079IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85083RQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85174VD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85213IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85231EY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85284LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85284MK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85302NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85310SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85315VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85366AQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85392NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85431OK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85463RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85483NO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85493TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85595RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85608AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85633MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85670FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85736BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85828UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85851IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85907UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85947FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85971OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85972OZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85972YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86002IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86013XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86050NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86083AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86085HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86167MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86173MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86186US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86196JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86199GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86239DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86294AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86304WJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G86320XR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86372GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86375CM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86387VT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G86389LM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86407VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86450IC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86469VE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86537AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86557DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86571PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86655NE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86656HK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86669AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86682HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86702JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86718YQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86733FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86736BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86861MW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86979CW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87014UA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87030ZZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87157JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87218FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87249CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87256FP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87280CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87310ZF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87418QZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87420IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87444MS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87514QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87574LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87666TN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87676CC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87683NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87755UZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G87756AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87808DX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87819IQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87847UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87935YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87945CD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G87984PA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87996EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88035KQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88050IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88139CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88188XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88204LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88212BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88216WD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88230UV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88286KJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88313DY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88356CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88357PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88376DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88432QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88449YB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88457GX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88500KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88505QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88508SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88567RB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88599FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88624YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88687UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88708RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88725FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88770MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88780VN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G88815IR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88837PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88856QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88936JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88975RE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89058LG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89104MS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89107UR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89119ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89129AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89137AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89210OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89215CC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89233QM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89242LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89242PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89257WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89270VP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89315II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89337EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89398MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89544LF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89585FG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89603EU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89611JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89661WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89721BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89748NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89753PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89769RM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89816MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89870ED", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89897ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89946SW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89990JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90103MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90135ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90146ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90153WX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90182FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90242XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90251SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90295ID", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90334GI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90350EB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90439ZM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90510OM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90572ER", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90575VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90634OE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90639RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90684PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90689AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90719NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90724OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90739UE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90746ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90767ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90789UO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90791MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90794QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90816KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90818DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90829NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90901EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90926WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90965BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90999PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90999QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91016QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91017HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91021AJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91041PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91043NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91047NA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91069QW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91083FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91143IL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91161VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91166AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91181WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91191RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91227PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91227UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91236EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91322OS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91368WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91410ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91459EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91474LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91484JV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91484XT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91618RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91637SF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91659ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91669BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91687HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91731DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91732VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91775YA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91788FV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91807FJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91809FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91863BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91875JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91883RB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92019ZO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92032WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92115RL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92142RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92155IO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92175OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92179IH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92190YN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92215RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92232VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92252GS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92296LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92324IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92332SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92354TO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92358PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92388MC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92399AI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92399PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92424DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92485YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92501LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92509CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92716MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92834ME", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92838RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92928SW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92933OP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92982UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93000QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93045SX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93088DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93195AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93239VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93279YE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93309ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93333OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93450CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93470LV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93505VZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93520MA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93523MF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93526OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93543SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93577ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93592ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93597FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93636BY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93696JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93706QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93763TV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93801LA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93828IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93861XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93909NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93910CU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93911DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93941QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93984MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93987XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93994EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93996ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94005KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94058TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94062FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94070ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94072JB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94085VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94092LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94146NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94161VQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94217FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94234FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94264FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94304ZN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94351CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94374SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94435QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94477RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94502LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94514IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94517VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94541HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94595ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94599QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94615OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94677FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94682VY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94705OR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94768NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94808XV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94817WU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94824OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94849XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94850KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94941PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95003CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95006CL", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G95035TM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95114RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95144UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95151JF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95259QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95292IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95324VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95329IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95353IZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95415HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95438ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95448VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95532JO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95560ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95586IZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95593KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95615QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95648NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95664HQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95675JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95715FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95715NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95739WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95740GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95889EP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95915TY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G95925PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95981KO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95997AL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96005ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96017QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96018DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96057TO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96066HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96067FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96079CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96119TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96169RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96334ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96373OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96409DQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G96463EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96483ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96540EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96568SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96576WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96599KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96622FI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96631UP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96643WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96653KP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96663HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96691CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96715CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96746BC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96758WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96763TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96820VB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96857WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96915PP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96921JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96943FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96971EN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97118EJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97123YR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97160DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97213ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97263AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97269SV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97271OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97316FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97345NY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97413OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97436XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97473TX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97494HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97515HE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97553OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97578GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97585KM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97586IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97595JJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97608ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97644GG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97647MG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97657WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97763JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97777ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97808FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97857BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97860FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97906UF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97972BA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98008PC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98073MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98074JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98126OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98166ZJ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G98200VV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98264BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98270SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98308VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98319WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98327TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98383AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98393IW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98412TA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98417SQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98473NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98479SI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98518WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98522DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98525PI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98535LH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98540XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98654DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98658WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98689EK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98698LI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98745FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98795OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98798WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98873GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98891IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98925GS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98950NH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G98977CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99019AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99039KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99041WC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99041XF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99069BG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99137GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99236CU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99244AI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99264QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99281CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99315PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99354AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99365LP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99372JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99423WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99448MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99454KR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99517NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99522JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99527BL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99556PB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99567UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99709XR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99730GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99738HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99738PW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99772FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99783GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99785MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99833CR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99938VL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99987ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99991DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99998AA", "type": "O-linked", "subtype": "Core 2" } ], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 313, "end_pos": 315 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYR5-1", "uniprot_ac": "Q3SYR5", "uniprot_id": "APOC4_BOVIN", "mass": { "chemical_mass": 14438.0, "monoisotopic_mass": 14438.0 }, "refseq": { "ac": "NP_001029979", "name": "apolipoprotein C-IV precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" }, "gene_names": [ { "name": "APOC4", "type": "recommended", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ] }, { "name": "APOC4", "type": "synonym", "evidence": [ { "id": "NP_001029979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" } ] } ], "protein_names": [ { "name": "Apolipoprotein C-IV", "type": "recommended", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5/entry#names_and_taxonomy" } ] }, { "name": "Apo-CIV", "type": "synonym", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5/entry#names_and_taxonomy" } ] }, { "name": "ApoC-IV", "type": "synonym", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5/entry#names_and_taxonomy" } ] }, { "name": "Apolipoprotein C4", "type": "synonym", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5/entry#names_and_taxonomy" } ] }, { "name": "apo-CIV", "type": "synonym", "evidence": [ { "id": "NP_001029979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" } ] }, { "name": "apoC-IV", "type": "synonym", "evidence": [ { "id": "NP_001029979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" } ] }, { "name": "apolipoprotein C-IV precursor", "type": "synonym", "evidence": [ { "id": "NP_001029979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" } ] }, { "name": "apolipoprotein C-IV", "type": "synonym", "evidence": [ { "id": "NP_001029979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979" } ] } ], "function": [ { "annotation": "May participate in lipoprotein metabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "APOC4", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5", "locus": { "chromosome": "18", "start_pos": 52654402, "end_pos": 52652024, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020556", "url": "https://www.ensembl.org/id/ENSBTAG00000020556" } ] } } ], "crossref": [ { "id": "Q3SYR5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020556", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020556", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618041", "url": "https://www.ncbi.nlm.nih.gov/gene/618041", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618041", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618041", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KWQWFWG", "url": "https://omabrowser.org/oma/group/KWQWFWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYR5", "url": "https://www.orthodb.org/?gene=Q3SYR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32288:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32288:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15119", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15119", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029979", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFPGCRPQALASLCFCVLVLACVVACQQEEPEGTLSPQPAPARSSWSLVPGKVKEWVEPLVNRTREKWKWFWGPTAFRGFMETYYDDHLKDLGSRARAWLRSSKDNLLNKAHSLCPQLLCRPSDQN", "length": 127, "header": "sp|Q3SYR5-1|APOC4_BOVIN Isoform 1 of Apolipoprotein C-IV OS=Bos taurus OX=9913 GN=APOC4 PE=2 SV=1 CANONICAL=Q3SYR5-1" }, "isoforms": [ { "isoform_ac": "Q3SYR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5/entry#Q3SYR5-1", "sequence": { "sequence": "MSFPGCRPQALASLCFCVLVLACVVACQQEEPEGTLSPQPAPARSSWSLVPGKVKEWVEPLVNRTREKWKWFWGPTAFRGFMETYYDDHLKDLGSRARAWLRSSKDNLLNKAHSLCPQLLCRPSDQN", "length": 127, "header": "sp|Q3SYR5-1|APOC4_BOVIN Isoform 1 of Apolipoprotein C-IV OS=Bos taurus OX=9913 GN=APOC4 PE=2 SV=1 CANONICAL=Q3SYR5-1" }, "locus": { "chromosome": "18", "start_pos": 52654382, "end_pos": 52652059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027391.4", "url": "https://www.ensembl.org/id/ENSBTAT00000027391.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027391.2", "url": "https://www.ensembl.org/id/ENSBTAP00000027391.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 63, "start_aa": "Asn", "end_pos": 63, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn63", "evidence": [ { "id": "Q3SYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:618041", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618041", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZPG0-1", "protein_name": "Apolipoprotein C-IV", "gene_name": "APOC4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLFLGGRPWALPSLCFCILVLACVVACQQAVLEESPTPSPEPKASHAWSLVPGKMKEWVQPLVTRTRERWEWFWGPGAFQGFVQTYYDDHLRDLGSRTKAWIHSSKDSLLNKAHSLCPQLFCGSRD", "length": 126 }, "evidence": [ { "id": "Q3SYR5", "url": "https://omabrowser.org/oma/group/Q3SYR5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P55056-1", "protein_name": "Apolipoprotein C-IV", "gene_name": "APOC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLRNRLQALPALCLCVLVLACIGACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFLESKDSLLKKTHSLCPRLVCGDKDQG", "length": 127 }, "evidence": [ { "id": "Q3SYR5", "url": "https://omabrowser.org/oma/group/Q3SYR5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P55797-1", "protein_name": "Apolipoprotein C-IV", "gene_name": "Apoc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLLRCRQQTLPSLCLSVLFLACFVASMPTESLTPTPGPENSRWSLVRARVMEMVEPLVTRTRDRWRWFWGPRAIQGFVQTYYEDHLKDLGPRTQAWLQSSRDHLLNKTHSLCPRLLCRDWTQG", "length": 124 }, "evidence": [ { "id": "Q3SYR5", "url": "https://omabrowser.org/oma/group/Q3SYR5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61268-1", "protein_name": "Apolipoprotein C-IV", "gene_name": "Apoc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLLRCRPRDLPSVSLSVLFLVSFVASMSTESLSPTPGPESSRWSLVRARVLEMVEPLVTRTRDRWQWFWGPGAVQGFMQTYYEDHLKDLGPRTQAWLQSSRDHLLNKTHSLCPRLLCKDRTQG", "length": 124 }, "evidence": [ { "id": "Q3SYR5", "url": "https://omabrowser.org/oma/group/Q3SYR5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "pmid": "" }, { "name": "triglyceride homeostasis", "id": "GO:0070328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070328", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "pmid": "" }, { "name": "lipid storage", "id": "GO:0019915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019915", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "high-density lipoprotein particle", "id": "GO:0034364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034364", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "pmid": "" }, { "name": "very-low-density lipoprotein particle", "id": "GO:0034361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034361", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR5", "url": "https://www.uniprot.org/uniprotkb/Q3SYR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYR5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 63 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYR7-1", "uniprot_ac": "Q3SYR7", "uniprot_id": "RL9_BOVIN", "mass": { "chemical_mass": 21876.0, "monoisotopic_mass": 21876.0 }, "refseq": { "ac": "NP_001019640", "name": "large ribosomal subunit protein uL6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019640" }, "gene_names": [ { "name": "RPL9", "type": "recommended", "evidence": [ { "id": "Q3SYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ] }, { "name": "RPL9", "type": "synonym", "evidence": [ { "id": "NP_001019640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019640" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL6", "type": "recommended", "evidence": [ { "id": "Q3SYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L9", "type": "synonym", "evidence": [ { "id": "NP_001019640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019640" }, { "id": "Q3SYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL6", "type": "synonym", "evidence": [ { "id": "NP_001019640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019640" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7#function" }, { "database": "UniProtKB", "id": "P32969", "url": "https://www.uniprot.org/uniprotkb/P32969#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL9", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7", "locus": { "chromosome": "6", "start_pos": 58564663, "end_pos": 58569422, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014518", "url": "https://www.ensembl.org/id/ENSBTAG00000014518" } ] } } ], "crossref": [ { "id": "Q3SYR7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014518", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282884", "url": "https://www.ncbi.nlm.nih.gov/gene/282884", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000702", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000702", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282884", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282884", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CASHITN", "url": "https://omabrowser.org/oma/group/CASHITN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYR7", "url": "https://www.orthodb.org/?gene=Q3SYR7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11655:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11655:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019640", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYR7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTILSNQTVDIPENVDINLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192, "header": "sp|Q3SYR7-1|RL9_BOVIN Isoform 1 of Large ribosomal subunit protein uL6 OS=Bos taurus OX=9913 GN=RPL9 PE=2 SV=1 CANONICAL=Q3SYR7-1" }, "isoforms": [ { "isoform_ac": "Q3SYR7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7/entry#Q3SYR7-1", "sequence": { "sequence": "MKTILSNQTVDIPENVDINLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192, "header": "sp|Q3SYR7-1|RL9_BOVIN Isoform 1 of Large ribosomal subunit protein uL6 OS=Bos taurus OX=9913 GN=RPL9 PE=2 SV=1 CANONICAL=Q3SYR7-1" }, "locus": { "chromosome": "6", "start_pos": 58568973, "end_pos": 58564979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019298.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019298.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019298.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019298.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282884", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282884", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140T8T4-1", "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "Rpl9-ps6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTILSNQTVDIPENVEITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFQYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRTGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192 }, "evidence": [ { "id": "Q3SYR7", "url": "https://omabrowser.org/oma/group/Q3SYR7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A287AW71-1", "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFHYKMRSVYAHFPINIVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192 }, "evidence": [ { "id": "Q3SYR7", "url": "https://omabrowser.org/oma/group/Q3SYR7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P05738-1", "protein_name": "Large ribosomal subunit protein uL6A", "gene_name": "RPL9A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGGRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFITEDL", "length": 191 }, "evidence": [ { "id": "Q3SYR7", "url": "https://omabrowser.org/oma/group/Q3SYR7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P17077-1", "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "Rpl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRTGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQPDE", "length": 192 }, "evidence": [ { "id": "Q3SYR7", "url": "https://omabrowser.org/oma/group/Q3SYR7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR7", "url": "https://www.uniprot.org/uniprotkb/Q3SYR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYR7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 192, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYR7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYR7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYS7-1", "uniprot_ac": "Q3SYS7", "uniprot_id": "IQCF1_BOVIN", "mass": { "chemical_mass": 24194.0, "monoisotopic_mass": 24194.0 }, "refseq": { "ac": "NP_001069241", "name": "IQ domain-containing protein F1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069241" }, "gene_names": [ { "name": "IQCF1", "type": "recommended", "evidence": [ { "id": "Q3SYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ] }, { "name": "IQCF1", "type": "synonym", "evidence": [ { "id": "NP_001069241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069241" } ] } ], "protein_names": [ { "name": "IQ domain-containing protein F1", "type": "recommended", "evidence": [ { "id": "Q3SYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7/entry#names_and_taxonomy" } ] }, { "name": "IQ domain-containing protein F1", "type": "synonym", "evidence": [ { "id": "NP_001069241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069241" } ] } ], "function": [ { "annotation": "Involved in sperm capacitation and acrosome reaction.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7#function" }, { "database": "UniProtKB", "id": "Q9D9K8", "url": "https://www.uniprot.org/uniprotkb/Q9D9K8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCF1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7", "locus": { "chromosome": "22", "start_pos": 49006034, "end_pos": 49003339, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000805", "url": "https://www.ensembl.org/id/ENSBTAG00000000805" } ] } } ], "crossref": [ { "id": "Q3SYS7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYS7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000805", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000805", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518447", "url": "https://www.ncbi.nlm.nih.gov/gene/518447", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518447", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518447", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TECIPFS", "url": "https://omabrowser.org/oma/group/TECIPFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYS7", "url": "https://www.orthodb.org/?gene=Q3SYS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21633", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21633", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21633:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21633:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069241", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYS7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METDQPKTVDENTENKPQENKGLVENSLPSEPSPTLEKAEAQQENKAATKGADDADKRSGVVTKPQKKPPVSDPEAVKIQAWWRGTLVRRTLLHAALRVWIIQAWWRVKLARLQDSRRRAALENFTRKEWAAVRLQSWVRMWRIRRRYCRLLDAARIIQAYWRCHSCTSRGFIKGYYRVTANQLHLELEILLGSGPCIVTECIPLPIKQ", "length": 209, "header": "sp|Q3SYS7-1|IQCF1_BOVIN Isoform 1 of IQ domain-containing protein F1 OS=Bos taurus OX=9913 GN=IQCF1 PE=2 SV=1 CANONICAL=Q3SYS7-1" }, "isoforms": [ { "isoform_ac": "Q3SYS7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7/entry#Q3SYS7-1", "sequence": { "sequence": "METDQPKTVDENTENKPQENKGLVENSLPSEPSPTLEKAEAQQENKAATKGADDADKRSGVVTKPQKKPPVSDPEAVKIQAWWRGTLVRRTLLHAALRVWIIQAWWRVKLARLQDSRRRAALENFTRKEWAAVRLQSWVRMWRIRRRYCRLLDAARIIQAYWRCHSCTSRGFIKGYYRVTANQLHLELEILLGSGPCIVTECIPLPIKQ", "length": 209, "header": "sp|Q3SYS7-1|IQCF1_BOVIN Isoform 1 of IQ domain-containing protein F1 OS=Bos taurus OX=9913 GN=IQCF1 PE=2 SV=1 CANONICAL=Q3SYS7-1" }, "locus": { "chromosome": "22", "start_pos": 49006023, "end_pos": 49003419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001065.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001065.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001065.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001065.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518447", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518447", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SET0-1", "protein_name": "IQ motif containing F1", "gene_name": "IQCF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEGQPTTIKEHTKKEPQQNEGLTALSSASSPTVKKEEAKQENIVATKRVDDAHKKPRLMPRIQNRFPITNPEVVKIQAWWRGTLVRRTLLHAALRVWIIQGWWREKLMKLEENRRRAVLETFTRKEWAAVRLQSWVRMWRIRRRYCRLLNAARIIQAYWRCHSCVSRGFIKGHYRVTANQLHLELEILLGSGPCIVTECIPLPIKQ", "length": 207 }, "evidence": [ { "id": "Q3SYS7", "url": "https://omabrowser.org/oma/group/Q3SYS7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZLI2-1", "protein_name": "IQ motif containing F1", "gene_name": "Iqcf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDEEQQKPEELNAPTDDDPQEKQEPADLSSETEKAESQKDQELSEKAQAVKIQAWWRGTLVRRGLLHAALRAWIIQCWWRLILTRIMEKRRQSVLDTFQQEQWAVVRLQAWIRMWRIRRRYCRLLKAVRTIQSYWRCHVCSSRGVIKGQYRISASQMHLELEVLLDSGPCIVTECIPLPIKQ", "length": 182 }, "evidence": [ { "id": "Q3SYS7", "url": "https://omabrowser.org/oma/group/Q3SYS7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N6M8-1", "protein_name": "IQ domain-containing protein F1", "gene_name": "IQCF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEKQPQKTKEPSKEDEPQQKEMPTHLSLGAESKAEAKTPVLVETQTVDNANEKSEKPPENQKKLSDKDTVATKIQAWWRGTLVRRALLHAALSACIIQCWWRLILSKILKKRRQAALEAFSRKEWAAVTLQSQARMWRIRRRYCQVLNAVRIIQAYWRCRSCASRGFIKGQYRVTANQLHLQLEILLDSGPCIVTECIPFSIKE", "length": 205 }, "evidence": [ { "id": "Q3SYS7", "url": "https://omabrowser.org/oma/group/Q3SYS7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9K8-1", "protein_name": "IQ domain-containing protein F1", "gene_name": "Iqcf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEEQQKPEELNAPTDDAPQEKQQPADLSSETEKAKSKKKQELSEKDQVVKIQAWWRGTLVRRSLLHAALSAWIIQCWWRLILPKIMEKRRQSMLDTFQQEQWAVVRLQSWIRMWRIRRRYCRLLKAVRTIQSHWRGHTCSSRGVIKGQYRISTSQMHLELEVLLGSGPCIVTECIPLPIKQ", "length": 182 }, "evidence": [ { "id": "Q3SYS7", "url": "https://omabrowser.org/oma/group/Q3SYS7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of acrosome reaction", "id": "GO:2000344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000344", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ], "pmid": "" }, { "name": "positive regulation of flagellated sperm motility involved in capacitation", "id": "GO:0060474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060474", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS7", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYS7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 209, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYS7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYS7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" }, { "id": "PRU00116", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQ 1", "eco_id": "ECO_0000255", "start_pos": 72, "end_pos": 101, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS7" }, { "id": "PRU00116", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQ 2", "eco_id": "ECO_0000255", "start_pos": 128, "end_pos": 157, "start_aa": "Lys", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYT7-1", "uniprot_ac": "Q3SYT7", "uniprot_id": "PSMD8_BOVIN", "mass": { "chemical_mass": 32538.0, "monoisotopic_mass": 32538.0 }, "refseq": {}, "gene_names": [ { "name": "PSMD8", "type": "recommended", "evidence": [ { "id": "Q3SYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 8", "type": "recommended", "evidence": [ { "id": "Q3SYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome regulatory subunit RPN12", "type": "synonym", "evidence": [ { "id": "Q3SYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7#function" }, { "database": "UniProtKB", "id": "P48556", "url": "https://www.uniprot.org/uniprotkb/P48556#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD8", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7", "locus": { "chromosome": "18", "start_pos": 48192106, "end_pos": 48185748, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031641", "url": "https://www.ensembl.org/id/ENSBTAG00000031641" } ] } } ], "crossref": [ { "id": "Q3SYT7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYT7", "database": "AlphaFoldDB", "categories": [] }, { "id": "512891", "url": "https://www.ncbi.nlm.nih.gov/gene/512891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512891", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512891", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYT7", "url": "https://www.orthodb.org/?gene=Q3SYT7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12387", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12387", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12387:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12387:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10075", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10075", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030283", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYT7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATAVNGVAGTSSSGSAAASGAILQAAAGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDIQEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGINNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV", "length": 287, "header": "sp|Q3SYT7-1|PSMD8_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 8 OS=Bos taurus OX=9913 GN=PSMD8 PE=2 SV=3 CANONICAL=Q3SYT7-1" }, "isoforms": [ { "isoform_ac": "Q3SYT7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7/entry#Q3SYT7-1", "sequence": { "sequence": "MAATAVNGVAGTSSSGSAAASGAILQAAAGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDIQEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGINNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV", "length": 287, "header": "sp|Q3SYT7-1|PSMD8_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 8 OS=Bos taurus OX=9913 GN=PSMD8 PE=2 SV=3 CANONICAL=Q3SYT7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "site_lbl": "Ser43" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512891", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512891", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "pmid": "" }, { "name": "proteasome regulatory particle, lid subcomplex", "id": "GO:0008541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008541", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3SYT7", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYT7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 287, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYT7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYT7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYT7" }, { "id": "PRU01185", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01185" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000255", "start_pos": 99, "end_pos": 268, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 43 ], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYV1-1", "uniprot_ac": "Q3SYV1", "uniprot_id": "TM263_BOVIN", "mass": { "chemical_mass": 11721.0, "monoisotopic_mass": 11721.0 }, "refseq": { "ac": "NP_001029845", "name": "transmembrane protein 263", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" }, "gene_names": [ { "name": "TMEM263", "type": "recommended", "evidence": [ { "id": "Q3SYV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1" } ] }, { "name": "C12orf23", "type": "synonym", "evidence": [ { "id": "NP_001029845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" } ] }, { "name": "C5H12orf23", "type": "synonym", "evidence": [ { "id": "NP_001029845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" } ] }, { "name": "TMEM263", "type": "synonym", "evidence": [ { "id": "NP_001029845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" } ] } ], "protein_names": [ { "name": "Transmembrane protein 263", "type": "recommended", "evidence": [ { "id": "Q3SYV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1/entry#names_and_taxonomy" } ] }, { "name": "UPF0444 transmembrane protein C12orf23 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" } ] }, { "name": "transmembrane protein 263", "type": "synonym", "evidence": [ { "id": "NP_001029845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845" } ] } ], "function": [ { "annotation": "May play a role in bone development.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1#function" }, { "database": "UniProtKB", "id": "Q8WUH6", "url": "https://www.uniprot.org/uniprotkb/Q8WUH6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYV1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM263", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1", "locus": { "chromosome": "5", "start_pos": 70253995, "end_pos": 70228954, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053105", "url": "https://www.ensembl.org/id/ENSBTAG00000053105" } ] } } ], "crossref": [ { "id": "Q3SYV1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "539347", "url": "https://www.ncbi.nlm.nih.gov/gene/539347", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539347", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539347", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31443", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31443", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15475", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15475", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029845", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYV1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQTDKNQQEIPSYLSDEPPEGSMKDHPQQQPGMLSRVTGGIFSVTKGAVGATIGGVAWIGGKSLEVTKTAVTTVPSMGIGLVKGGVSAVAGGVTAVGSAVVNKVPLTGKKKDKSD", "length": 116, "header": "sp|Q3SYV1-1|TM263_BOVIN Isoform 1 of Transmembrane protein 263 OS=Bos taurus OX=9913 GN=TMEM263 PE=3 SV=1 CANONICAL=Q3SYV1-1" }, "isoforms": [ { "isoform_ac": "Q3SYV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1/entry#Q3SYV1-1", "sequence": { "sequence": "MNQTDKNQQEIPSYLSDEPPEGSMKDHPQQQPGMLSRVTGGIFSVTKGAVGATIGGVAWIGGKSLEVTKTAVTTVPSMGIGLVKGGVSAVAGGVTAVGSAVVNKVPLTGKKKDKSD", "length": 116, "header": "sp|Q3SYV1-1|TM263_BOVIN Isoform 1 of Transmembrane protein 263 OS=Bos taurus OX=9913 GN=TMEM263 PE=3 SV=1 CANONICAL=Q3SYV1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 2, "start_aa": "Asn", "end_pos": 2, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2", "evidence": [ { "id": "Q3SYV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539347", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539347", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYV1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 116, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYV1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYV1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 2 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYV7-1", "uniprot_ac": "Q3SYV7", "uniprot_id": "ZN345_BOVIN", "mass": { "chemical_mass": 55270.0, "monoisotopic_mass": 55270.0 }, "refseq": { "ac": "NP_001030404", "name": "zinc finger protein 345", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030404" }, "gene_names": [ { "name": "ZNF345", "type": "recommended", "evidence": [ { "id": "Q3SYV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ] }, { "name": "ZNF345", "type": "synonym", "evidence": [ { "id": "NP_001030404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030404" } ] } ], "protein_names": [ { "name": "Zinc finger protein 345", "type": "recommended", "evidence": [ { "id": "Q3SYV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 345", "type": "synonym", "evidence": [ { "id": "NP_001030404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030404" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF345", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7", "locus": { "chromosome": "18", "start_pos": 47568288, "end_pos": 47584114, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008902", "url": "https://www.ensembl.org/id/ENSBTAG00000008902" } ] } } ], "crossref": [ { "id": "Q3SYV7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008902", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008902", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518207", "url": "https://www.ncbi.nlm.nih.gov/gene/518207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518207", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518207", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRHFSEM", "url": "https://omabrowser.org/oma/group/HRHFSEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYV7", "url": "https://www.orthodb.org/?gene=Q3SYV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030404", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYV7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERLIKNSIAYSRFRGDWECKSQFERKQESQEGHLSQMIFTPEDMPTFNTQHQRIHTDEKLLECKECGKDFSFVSVLIRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPYECNECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSGEKPYECKVCGKSFSFESALTRHHRIHTGEKPYECKDCGKAFGSGSNLTQHRRVHTGEKPYECKGCGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQRMHTGEKPYECKECGKAFSSGSDLTQHQRIHTGEKPYECKECGKAFASGSKLIQHQLIHTGEKPYECRECRKSFSSGSALNRHQRIHTGQKPYECKECEKTFGTGSTLTQHQRMHTAEKLYECKACGKALGRGSEIQQHKKNHAGEKLCELETP", "length": 487, "header": "sp|Q3SYV7-1|ZN345_BOVIN Isoform 1 of Zinc finger protein 345 OS=Bos taurus OX=9913 GN=ZNF345 PE=2 SV=1 CANONICAL=Q3SYV7-1" }, "isoforms": [ { "isoform_ac": "Q3SYV7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7/entry#Q3SYV7-1", "sequence": { "sequence": "MERLIKNSIAYSRFRGDWECKSQFERKQESQEGHLSQMIFTPEDMPTFNTQHQRIHTDEKLLECKECGKDFSFVSVLIRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPYECNECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSGEKPYECKVCGKSFSFESALTRHHRIHTGEKPYECKDCGKAFGSGSNLTQHRRVHTGEKPYECKGCGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQRMHTGEKPYECKECGKAFSSGSDLTQHQRIHTGEKPYECKECGKAFASGSKLIQHQLIHTGEKPYECRECRKSFSSGSALNRHQRIHTGQKPYECKECEKTFGTGSTLTQHQRMHTAEKLYECKACGKALGRGSEIQQHKKNHAGEKLCELETP", "length": 487, "header": "sp|Q3SYV7-1|ZN345_BOVIN Isoform 1 of Zinc finger protein 345 OS=Bos taurus OX=9913 GN=ZNF345 PE=2 SV=1 CANONICAL=Q3SYV7-1" }, "locus": { "chromosome": "18", "start_pos": 47571150, "end_pos": 47569690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026567.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026567.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026567.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026567.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518207", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518207", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14585-1", "protein_name": "Zinc finger protein 345", "gene_name": "ZNF345", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENLTKHSIECSSFRGDWECKNQFERKQGSQEGHFSEMIFTPEDMPTFSIQHQRIHTDEKLLECKECGKDFSFVSVLVRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPFECKECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAFGSGSNLTQHRRIHTGEKPYECKACGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQRMHTGEKPYECKECGKTFSSGSDLTQHHRIHTGEKPYECKECGKAFGSGSKLIQHQLIHTGERPYECKECGKSFSSGSALNRHQRIHTGEKPYECKECGKAFYSGSSLTQHQRIHTGEKLYECKNCGKAYGRDSEFQQHKKSHNGKKLCELETIN", "length": 488 }, "evidence": [ { "id": "Q3SYV7", "url": "https://omabrowser.org/oma/group/Q3SYV7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV7", "url": "https://www.uniprot.org/uniprotkb/Q3SYV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYV7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 487, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYV7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYV7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYW0-1", "uniprot_ac": "Q3SYW0", "uniprot_id": "FBX15_BOVIN", "mass": { "chemical_mass": 51967.0, "monoisotopic_mass": 51967.0 }, "refseq": { "ac": "NP_001030193", "name": "F-box only protein 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030193" }, "gene_names": [ { "name": "FBXO15", "type": "recommended", "evidence": [ { "id": "Q3SYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0" } ] }, { "name": "FBXO15", "type": "synonym", "evidence": [ { "id": "NP_001030193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030193" } ] } ], "protein_names": [ { "name": "F-box only protein 15", "type": "recommended", "evidence": [ { "id": "Q3SYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 15", "type": "synonym", "evidence": [ { "id": "NP_001030193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030193" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW0", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYW0", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO15", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0", "locus": { "chromosome": "24", "start_pos": 4282302, "end_pos": 4244203, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009686", "url": "https://www.ensembl.org/id/ENSBTAG00000009686" } ] } } ], "crossref": [ { "id": "Q3SYW0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009686", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009686", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22093", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22093", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505376", "url": "https://www.ncbi.nlm.nih.gov/gene/505376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MWY3", "url": "https://www.orthodb.org/?gene=A0A3Q1MWY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIC0", "url": "https://www.orthodb.org/?gene=A0A452DIC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SYW0", "url": "https://www.orthodb.org/?gene=Q3SYW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46731", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46731", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46731:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46731:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030193", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWY3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIC0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY12", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY12-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYW0", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYW0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPAGPAALSRRARQDKVCRRPSTGCSASLDSLPSEVLLKILSYLDAAALLCAGCVNRRFYHLANDNFIWIRIYSTAFSPRRSHWRVDPAEKTDLSVNLLSAGDKEAGYWKKEYLTKQIASVKAALARVLKPLHPHTGLPVKTKEALRVSGLGWVIILRAADGREYTMEHADLSVNDSSVTVVWYGKDWPPLATLSTLDLCGATPVFMGQSRTPSRIRPRWHSLITKYQLSQLTESSAVGGDRLMRVFCLPPGLVVGLWKREEELAFVMANLHLHCLVERSMLGSPAVPYELPPHTPVSDDSPERGLHGYRLHVDMHSGGASCLCGSFHNLSASKGYLENEYMKLTVISFKNNTEHLPLIGKVGLSWKTNSFDGCIKSCSIMDLTLLEEYGKPFWCFSSPVCVRCCPGPSDGPSFLGEAYCVDYSDSEGRLHMELVWVEETEEYFIVSLALYLRLAKVNQWFGTQY", "length": 466, "header": "sp|Q3SYW0-1|FBX15_BOVIN Isoform 1 of F-box only protein 15 OS=Bos taurus OX=9913 GN=FBXO15 PE=2 SV=1 CANONICAL=Q3SYW0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MWY3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0/entry#A0A3Q1MWY3-1", "sequence": { "sequence": "MAIGRGRLLQLQWQCLLARPPPLGCFGSAFASPGAAAGRAGFRMRPGAMLPAGPAALSRRARQDKVCRRPSTGCSASLDSLPSEVLLKILSYLDAAALLCAGCVNRRFYHLANDNFIWIRIYSTAFSPRRSHWRVDPAEKTDLSVNLLSAGDKEAGYWKKEYLTKQIASVKAALARVLKPLHPHTGLPVKTKEALRVSGLGWVIILRAADGREYTMEHADLSVNDSSVTVVWYGKDWPPLATLSTLDLCGATPVFMGQSRTPSRIRPRWHSLITKYQLSQLTESSAVGGDRLMRVFCLPPGLVVGLWKREEELAFVMANLHLHCLVERSMLGSPAVPYELPPHTPVSDDSPERGLHGYRLHVDMHSGGASCLCGSFHNLSASKELLYNGPNSSGGVREALLVLQFPGVRAVLPRALRRPQFLGGGILCGLLGFGRKAAHGAGVGRGDGGVLHRQPGPLPAVGESKPVVWDTILSGSNRWQIIIAVCFHRTNWFCSWCLS", "length": 499, "header": "tr|A0A3Q1MWY3-1|A0A3Q1MWY3_BOVIN Computationally mapped isoform of F-box protein 15 OS=Bos taurus OX=9913 GN=FBXO15 PE=4 SV=2 CANONICAL=Q3SYW0-1" }, "locus": { "chromosome": "24", "start_pos": 4281827, "end_pos": 4244211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075750.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075750.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060132.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060132.2" } ] } }, { "isoform_ac": "A0A452DIC0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0/entry#A0A452DIC0-1", "sequence": { "sequence": "MAIGRGRLLQLQWQCLLARPPPLGCFGSAFASPGAAAGRAGFRMRPGAMLPAGPAALSRRARQDKVCRRPSTGCSASLDSLPSEVLLKILSYLDAAALLCAGCVNRRFYHLANDNFIWIRIYSTAFSPRRSHWRVDPAEKTDLSVNLLSAGDKEAGYWKKEYLTKQIASVKAALARVLKPLHPHTGLPVKTKEALRVSGLGWVIILRAADGREYTMEHADLSVNDSSVTVVWYGKDWPPLATLSTLDLCGATPVFMGQSRTPSRIRPRWHSLITKYQLSQLTESSAVGGDRLMRVFCLPPGLVVGLWKGTLMLHECWGVNASGSTHCASRVPCGPAVTVTSYQAVMREEELAFVMANLHLHCLVERSMLGSPAVPYELPPHTPVSDDSPERGLHGYRLHVDMHSGGASCLCGSFHNLSASKGYLENEYMKLTVISFKNNTEHLPLIGKVGLSWKTNSFDGCIKSCSIMDLTLLEEYGKPFWCFSSPVCVRCCPGPSDGPSFLGEAYCVDYSDSEGRLHMELVWVEETEEYFIVSLALYLRLAKVNQWFGTQY", "length": 552, "header": "tr|A0A452DIC0-1|A0A452DIC0_BOVIN Computationally mapped isoform of F-box protein 15 OS=Bos taurus OX=9913 GN=FBXO15 PE=4 SV=2 CANONICAL=Q3SYW0-1" }, "locus": { "chromosome": "24", "start_pos": 4281747, "end_pos": 4244211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012776.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012776.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012776.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012776.4" } ] } }, { "isoform_ac": "A0ABI0NY12-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0/entry#A0ABI0NY12-1", "sequence": { "sequence": "MAIGRGRLLQLQWQCLLARPPPLGCFGSAFASPGAAAGRAGFRMRPGAMLPAGPAALSRRARQDKVCRRPSTGCSASLDSLPSEVLLKILSYLDAAALLCAGCVNRRFYHLANDNFIWIRIYSTAFSPRRSHWRVDPAEKTDLSVNLLSAGDKEAGYWKKEYLTKQIASVKAALARVLKPLHPHTGLPVKTKEALRVSGLGWVIILRAADGREYTMEHADLSVNDSSVTVVWYGKDWPPLATLSTLDLCGATPVFMGQSRTPSRIRPRWHSLITKYQLSQLTESSAVGGDRLMRVFCLPPGLVVGLWKREEELAFVMANLHLHCLVERSMLGSPAVPYELPPHTPVSDDSPERGLHGYRLHVDMHSGGASCLCGSFHNLSASKGYLENEYMKLTVISFKNNTEHLPLIGKVGLSWKTNSFDGCIKSCSIMDLTLLEEYGKPFWCFSSPVCVRCCPGPSDGPSFLGEAYCVDYSDSEGRLHMELVWVEETEEYFIVSLALYLRLAKVNQWFGTQY", "length": 514, "header": "tr|A0ABI0NY12-1|A0ABI0NY12_BOVIN Computationally mapped isoform of F-box protein 15 OS=Bos taurus OX=9913 GN=FBXO15 PE=4 SV=1 CANONICAL=Q3SYW0-1" }, "locus": { "chromosome": "24", "start_pos": 4281747, "end_pos": 4244211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148251.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148251.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105818.1" } ] } }, { "isoform_ac": "Q3SYW0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0/entry#Q3SYW0-1", "sequence": { "sequence": "MLPAGPAALSRRARQDKVCRRPSTGCSASLDSLPSEVLLKILSYLDAAALLCAGCVNRRFYHLANDNFIWIRIYSTAFSPRRSHWRVDPAEKTDLSVNLLSAGDKEAGYWKKEYLTKQIASVKAALARVLKPLHPHTGLPVKTKEALRVSGLGWVIILRAADGREYTMEHADLSVNDSSVTVVWYGKDWPPLATLSTLDLCGATPVFMGQSRTPSRIRPRWHSLITKYQLSQLTESSAVGGDRLMRVFCLPPGLVVGLWKREEELAFVMANLHLHCLVERSMLGSPAVPYELPPHTPVSDDSPERGLHGYRLHVDMHSGGASCLCGSFHNLSASKGYLENEYMKLTVISFKNNTEHLPLIGKVGLSWKTNSFDGCIKSCSIMDLTLLEEYGKPFWCFSSPVCVRCCPGPSDGPSFLGEAYCVDYSDSEGRLHMELVWVEETEEYFIVSLALYLRLAKVNQWFGTQY", "length": 466, "header": "sp|Q3SYW0-1|FBX15_BOVIN Isoform 1 of F-box only protein 15 OS=Bos taurus OX=9913 GN=FBXO15 PE=2 SV=1 CANONICAL=Q3SYW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505376", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW0", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 466, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYW0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYW0" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 27, "end_pos": 73, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 352, "end_pos": 354 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYW5-1", "uniprot_ac": "Q3SYW5", "uniprot_id": "AZI2_BOVIN", "mass": { "chemical_mass": 44917.0, "monoisotopic_mass": 44917.0 }, "refseq": { "ac": "NP_001070473", "name": "5-azacytidine-induced protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070473" }, "gene_names": [ { "name": "AZI2", "type": "recommended", "evidence": [ { "id": "Q3SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ] }, { "name": "AZI2", "type": "synonym", "evidence": [ { "id": "NP_001070473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070473" } ] } ], "protein_names": [ { "name": "5-azacytidine-induced protein 2", "type": "recommended", "evidence": [ { "id": "Q3SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5/entry#names_and_taxonomy" } ] }, { "name": "5-azacytidine-induced protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070473" } ] } ], "function": [ { "annotation": "Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5#function" }, { "database": "UniProtKB", "id": "Q9H6S1", "url": "https://www.uniprot.org/uniprotkb/Q9H6S1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AZI2", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5", "locus": { "chromosome": "22", "start_pos": 2757707, "end_pos": 2798686, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004117", "url": "https://www.ensembl.org/id/ENSBTAG00000004117" } ] } } ], "crossref": [ { "id": "Q3SYW5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004117", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004117", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767932", "url": "https://www.ncbi.nlm.nih.gov/gene/767932", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024581", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024581", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767932", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767932", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PWPSQSC", "url": "https://omabrowser.org/oma/group/PWPSQSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYW5", "url": "https://www.orthodb.org/?gene=Q3SYW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14432", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14432", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14432:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14432:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12845", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12845", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070473", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYW5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDALVEDDICILNHEKAHRRDPVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRILEEKLIGARKDEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVIRNLNPPSSNWEVEKLSCDLKIHGLEQELELLRKECRDLRIELQKAKQTDPSLDDNLNCRDLQRLSVSSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPAAIKKACAPAGCMEDLGKDSTKLHLSNFTAAYKRHAPLSPNGKTLCHATPSPLPGDAKVLSEKAALQSWTDHERSIPHDGTNFQEHNSYSRNSLEDNSWVFPSPPKSSETTFGEMKSKPLPLPNLPPLHYLDQHNQNCHYKH", "length": 393, "header": "sp|Q3SYW5-1|AZI2_BOVIN Isoform 1 of 5-azacytidine-induced protein 2 OS=Bos taurus OX=9913 GN=AZI2 PE=2 SV=1 CANONICAL=Q3SYW5-1" }, "isoforms": [ { "isoform_ac": "Q3SYW5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5/entry#Q3SYW5-1", "sequence": { "sequence": "MDALVEDDICILNHEKAHRRDPVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRILEEKLIGARKDEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVIRNLNPPSSNWEVEKLSCDLKIHGLEQELELLRKECRDLRIELQKAKQTDPSLDDNLNCRDLQRLSVSSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPAAIKKACAPAGCMEDLGKDSTKLHLSNFTAAYKRHAPLSPNGKTLCHATPSPLPGDAKVLSEKAALQSWTDHERSIPHDGTNFQEHNSYSRNSLEDNSWVFPSPPKSSETTFGEMKSKPLPLPNLPPLHYLDQHNQNCHYKH", "length": 393, "header": "sp|Q3SYW5-1|AZI2_BOVIN Isoform 1 of 5-azacytidine-induced protein 2 OS=Bos taurus OX=9913 GN=AZI2 PE=2 SV=1 CANONICAL=Q3SYW5-1" }, "locus": { "chromosome": "22", "start_pos": 2773852, "end_pos": 2757948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005379.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005379.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005379.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005379.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 319, "end_pos": 319, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ], "site_lbl": "Ser319" }, { "start_pos": 354, "end_pos": 354, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ], "site_lbl": "Ser354" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767932", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767932", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MAC7-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "Azi2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDTLVEDDICILNHEKAQRREAVMPLSVYSGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEEKLVGARVDEETSSVGREQVNKAYHAYREVCIDRDNLKNKLEKINKDNTESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSLDLKIHGLEQELEVMRKECHDLKIELQKAKQTGPPQENIPQDRDLIRRSLSREEDGPHQGLLHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAIKKACTPAGCVEDLGKDLAKLHLTNFTATYKRYPPLSPNGKATCYAPPSTLPGDTKVLSDKAVLQSWTDNERLIPNDGTDFQEHNSYGRNSLDDNSWVFPSPPKSSETTFGENKNKTFPLSNLPPLHYLDQHNQNCLYKS", "length": 405 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XAW0-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "AZI2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEELVEDDICILNHEKADNSHKRDGDIPVSAYSGDESVASHFALVTAYEDIKKRLKETEKENSFLKKRVRILEEKLLGSRLEEECSSVGREQVNKAYQAYREVCIDRDNLKSKLDKMTKETAESLKNLNEQLQSKEVELLQLKTEVETQQVMKSLNCCTQTSWEIEKLNSDLKVHSLEQDLENLKQECNSLRKELQKYKQKDQDQDENPLNGDILQRQAVQSVQQAYWELKREMSNLQLVTEVQTEVLRKLKTNITATKKAASSAPVQCVELKNITRQNLMSGVVYKKLSQSDKVHCNAAPPPLPGHVKIPSERVILQAWTDEGPIPVDGETFQEHHSYGKSSLEDNSWVFPSPPKPNENVFWETNKVLSNCPADYLDQCNQNCLHKN", "length": 388 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LKX7-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "AZI2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEALIDDDICILDHEKAHRRDTVTPVSIYSDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRFLEEKLLGARKDEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKINKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVIRNLNPPSSNWEVEKLSCDLKIHGLEQELELMKKECRDLKIELQKAKQTDPPQEDSLKSRDLQRLSTSSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIKKAGTPAGYTEDLGKESTKLHLTNLTAAYRRQPTLSPNSRALCQATPSPLPGDTKVLSERAILQSWTDNEQTILHDNTDFQEHNSYGRNSLEDNSWVFPSPPKSSETPFGEAKNKTLPLPNLPPLHYLDQRNQNCQYKS", "length": 392 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4KMA0-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "Azi2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTLVEDDICILNHEKAHKREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEEKLVGARVEEETSSVGREQVNKAYHAYREVCIDRDNLKSRLEKISKDNSESLRALTEQLQCKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELLRKECSDLRTELQKARQTGPSQEDILQDRDVIRPSLPREEHVPHQGPHHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGKACTQVGCVEDLGRDSAKLHLANCTAAYKRHPPLSPHGKATCYAPPSTLPGDRKAFSDKAVLQSWTDNERLTPNDGADFQEHNSYGRNSLEDNSWVFPSPPKSSETAFGESKSKILPSPNLPPLHYLDQHNQNCLYKS", "length": 404 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H6S1-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "AZI2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN", "length": 392 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QYP6-1", "protein_name": "5-azacytidine-induced protein 2", "gene_name": "Azi2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTGPPQEDILQGRDVIRPSLSREEHVPHQGLHHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKACTPVGCVEDLGRDSTKLHLTNFTATYKRHPSLSPNGKAPCYAPSSPLPGDRKVFSDKAVLQSWTDNERLVPNDGADFPEHSSYGRNSLEDNSWVFPSPPKSSETAFGENKSKILPLSNLPPLHYLDQQNQNCLYKS", "length": 405 }, "evidence": [ { "id": "Q3SYW5", "url": "https://omabrowser.org/oma/group/Q3SYW5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "Q3SYW5", "url": "https://www.uniprot.org/uniprotkb/Q3SYW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYW5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYW5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYW5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 319, 354 ], "sequon_annotation_sites": [ { "start_pos": 278, "end_pos": 280 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYY7-1", "uniprot_ac": "Q3SYY7", "uniprot_id": "OCAD2_BOVIN", "mass": { "chemical_mass": 16845.0, "monoisotopic_mass": 16845.0 }, "refseq": { "ac": "NP_001029430", "name": "OCIA domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029430" }, "gene_names": [ { "name": "OCIAD2", "type": "recommended", "evidence": [ { "id": "Q3SYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ] }, { "name": "OCIAD2", "type": "synonym", "evidence": [ { "id": "NP_001029430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029430" } ] } ], "protein_names": [ { "name": "OCIA domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q3SYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7/entry#names_and_taxonomy" } ] }, { "name": "OCIA domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001029430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029430" } ] } ], "function": [ { "annotation": "Has an essential role in the assembly of mitochondrial respiratory chain complex III. Is also required for STAT3 activation and plays a role in cell migration.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7#function" }, { "database": "UniProtKB", "id": "Q56VL3", "url": "https://www.uniprot.org/uniprotkb/Q56VL3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OCIAD2", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7", "locus": { "chromosome": "6", "start_pos": 67528050, "end_pos": 67539862, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001839", "url": "https://www.ensembl.org/id/ENSBTAG00000001839" } ] } } ], "crossref": [ { "id": "Q3SYY7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505877", "url": "https://www.ncbi.nlm.nih.gov/gene/505877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505877", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505877", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GIGPWSK", "url": "https://omabrowser.org/oma/group/GIGPWSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYY7", "url": "https://www.orthodb.org/?gene=Q3SYY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13336:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13336:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYY7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVSTHENQEKGPHLPPPSKQSLLFCPKSKLHIHRSEISKIIRECQEESFWKRALPFSLVSMLVTQGLVHHGYLAANPRFGSLPKVALAGILGFGLGKASYIGVCQSKFHSFEGQLRGAGFGPGHNRHCLLTCEECKTKHGLSQERSSQPSAS", "length": 154, "header": "sp|Q3SYY7-1|OCAD2_BOVIN Isoform 1 of OCIA domain-containing protein 2 OS=Bos taurus OX=9913 GN=OCIAD2 PE=2 SV=1 CANONICAL=Q3SYY7-1" }, "isoforms": [ { "isoform_ac": "Q3SYY7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7/entry#Q3SYY7-1", "sequence": { "sequence": "MASVSTHENQEKGPHLPPPSKQSLLFCPKSKLHIHRSEISKIIRECQEESFWKRALPFSLVSMLVTQGLVHHGYLAANPRFGSLPKVALAGILGFGLGKASYIGVCQSKFHSFEGQLRGAGFGPGHNRHCLLTCEECKTKHGLSQERSSQPSAS", "length": 154, "header": "sp|Q3SYY7-1|OCAD2_BOVIN Isoform 1 of OCIA domain-containing protein 2 OS=Bos taurus OX=9913 GN=OCIAD2 PE=2 SV=1 CANONICAL=Q3SYY7-1" }, "locus": { "chromosome": "6", "start_pos": 67537344, "end_pos": 67529113, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027443.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027443.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027443.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027443.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505877", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505877", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IEB3-1", "protein_name": "OCIA domain-containing protein 2", "gene_name": "Ociad2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASVSTHGNQEKSPHLPPLSKQSLLFCPKSKLHIHRGEIAKIIRECQEESFWKRALPFSLISMLVTQGLVHQGYLAANPRFGSLPKVALAGLLGFGLGKASYIRVCQSKFHSFEDQLRGAGFGPEHNRHCLLTCEECKTRRGLSEQKGPQPSHS", "length": 154 }, "evidence": [ { "id": "Q3SYY7", "url": "https://omabrowser.org/oma/group/Q3SYY7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q56VL3-1", "protein_name": "OCIA domain-containing protein 2", "gene_name": "OCIAD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMRECQEESFWKRALPFSLVSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS", "length": 154 }, "evidence": [ { "id": "Q3SYY7", "url": "https://omabrowser.org/oma/group/Q3SYY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D8W7-1", "protein_name": "OCIA domain-containing protein 2", "gene_name": "Ociad2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASVSTHGNQEKSPHLPPLSKQSLLFCPKSKLHIHRGEIAKIIRECQEESFWKRALPFSLISMLVTQGLVHQGYLAANPRFGSLPKVALAGLLGFGLGKASYIRVCQSKFHSFEDQLRGAGFGPEHNRHCLLTCEDCKTRRGLSEKAGSQPSAS", "length": 154 }, "evidence": [ { "id": "Q3SYY7", "url": "https://omabrowser.org/oma/group/Q3SYY7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex III assembly", "id": "GO:0034551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034551", "evidence": [ { "database": "UniProtKB", "id": "Q3SYY7", "url": "https://www.uniprot.org/uniprotkb/Q3SYY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYY7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYZ6-1", "uniprot_ac": "Q3SYZ6", "uniprot_id": "XYLB_BOVIN", "mass": { "chemical_mass": 53305.0, "monoisotopic_mass": 53305.0 }, "refseq": { "ac": "NP_001029655", "name": "xylulose kinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029655" }, "gene_names": [ { "name": "XYLB", "type": "recommended", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ] }, { "name": "XYLB", "type": "synonym", "evidence": [ { "id": "NP_001029655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029655" } ] } ], "protein_names": [ { "name": "Xylulose kinase", "type": "recommended", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.17", "type": "synonym", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#names_and_taxonomy" } ] }, { "name": "Xylulokinase", "type": "synonym", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#names_and_taxonomy" } ] }, { "name": "xylulokinase homolog (H. influenzae)", "type": "synonym", "evidence": [ { "id": "NP_001029655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029655" } ] }, { "name": "xylulose kinase", "type": "synonym", "evidence": [ { "id": "NP_001029655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029655" } ] } ], "function": [ { "annotation": "Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NGI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGI1#function" }, { "database": "UniProtKB", "id": "ARBA00003260", "url": "https://www.uniprot.org/uniprotkb/ARBA00003260#function" }, { "database": "UniProtKB", "id": "RU367058", "url": "https://www.uniprot.org/uniprotkb/RU367058#function" }, { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6#function" }, { "database": "UniProtKB", "id": "A0A3Q1MR05", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR05#function" }, { "database": "UniProtKB", "id": "A0AAF6ZAX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAX2#function" }, { "database": "UniProtKB", "id": "A0ABI0NLG3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLG3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LRL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XYLB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6", "locus": { "chromosome": "22", "start_pos": 11817613, "end_pos": 11777008, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011278", "url": "https://www.ensembl.org/id/ENSBTAG00000011278" } ] } } ], "crossref": [ { "id": "Q3SYZ6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYZ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07776", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07776", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515146", "url": "https://www.ncbi.nlm.nih.gov/gene/515146", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515146", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515146", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRL7", "url": "https://www.orthodb.org/?gene=A0A3Q1LRL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR05", "url": "https://www.orthodb.org/?gene=A0A3Q1MR05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NGI1", "url": "https://www.orthodb.org/?gene=A0A3Q1NGI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SYZ6", "url": "https://www.orthodb.org/?gene=Q3SYZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029655", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10964", "url": "https://www.rhea-db.org/rhea/10964", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR05", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR05-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLG3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLG3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYZ6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGPSLLCLVSIY", "length": 490, "header": "sp|Q3SYZ6-1|XYLB_BOVIN Isoform 1 of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=2 SV=1 CANONICAL=Q3SYZ6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRL7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#A0A3Q1LRL7-1", "sequence": { "sequence": "MKASGFDFSQVLALSGAGQRHLCGPRPGTHCVSLGLCSTFLPPAYLLQDSHKHFHPFNSGRPEFSPAQDKTQPPEHGCQGQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGLAAGTDMPFAEIVKLAPNPRLVATPTPGASQPPRFL", "length": 499, "header": "tr|A0A3Q1LRL7-1|A0A3Q1LRL7_BOVIN Computationally mapped isoform of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=1 SV=3 CANONICAL=Q3SYZ6-1" }, "locus": { "chromosome": "22", "start_pos": 11824552, "end_pos": 11783217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076358.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076358.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057700.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057700.3" } ] } }, { "isoform_ac": "A0A3Q1MR05-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#A0A3Q1MR05-1", "sequence": { "sequence": "MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGLAAGTDMPFAEIVKLAPNPRLVATPTPGASQVYEALLQRYAMLEQRVLSQTRGPPE", "length": 509, "header": "tr|A0A3Q1MR05-1|A0A3Q1MR05_BOVIN Computationally mapped isoform of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=1 SV=3 CANONICAL=Q3SYZ6-1" }, "locus": { "chromosome": "22", "start_pos": 11816609, "end_pos": 11777050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077221.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077221.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056800.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056800.3" } ] } }, { "isoform_ac": "A0A3Q1NGI1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#A0A3Q1NGI1-1", "sequence": { "sequence": "MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGLAAGTDMPFAEIVKLAPNPRLVATPTPGASQDYRSR", "length": 516, "header": "tr|A0A3Q1NGI1-1|XYLB_BOVIN Computationally mapped isoform of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=2 SV=2 CANONICAL=Q3SYZ6-1" }, "locus": { "chromosome": "22", "start_pos": 11812127, "end_pos": 11777050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081965.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081965.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070916.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070916.2" } ] } }, { "isoform_ac": "A0AAF6ZAX2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#A0AAF6ZAX2-1", "sequence": { "sequence": "MKASGFDFSQVLALSGAGQRHLCGPRPGTHCVSLGLCSTFLPPAYLLQDSHKHFHPFNSGRPEFSPAQDKTQPPEHGCQGQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGPSLLCLVSIY", "length": 473, "header": "tr|A0AAF6ZAX2-1|A0AAF6ZAX2_BOVIN Computationally mapped isoform of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=1 SV=2 CANONICAL=Q3SYZ6-1" }, "locus": { "chromosome": "22", "start_pos": 11810866, "end_pos": 11783217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030851.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030851.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030820.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030820.4" } ] } }, { "isoform_ac": "A0ABI0NLG3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#A0ABI0NLG3-1", "sequence": { "sequence": "MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGLAAGTDMPFAEIVKLAPNPRLVATPTPGASQVYEALLQRYAMLEQRVLSQTRGPPE", "length": 536, "header": "tr|A0ABI0NLG3-1|A0ABI0NLG3_BOVIN Computationally mapped isoform of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=1 SV=1 CANONICAL=Q3SYZ6-1" }, "locus": { "chromosome": "22", "start_pos": 11816609, "end_pos": 11777050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154204.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154204.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105946.1" } ] } }, { "isoform_ac": "Q3SYZ6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6/entry#Q3SYZ6-1", "sequence": { "sequence": "MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGPSLLCLVSIY", "length": 490, "header": "sp|Q3SYZ6-1|XYLB_BOVIN Isoform 1 of Xylulose kinase OS=Bos taurus OX=9913 GN=XYLB PE=2 SV=1 CANONICAL=Q3SYZ6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515146", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515146", "resource": "KEGG Pathway" }, { "id": "R-BTA-5661270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661270", "resource": "Reactome", "description": "Formation of xylulose-5-phosphate" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "xylulose metabolic process", "id": "GO:0005997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005997", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "pmid": "" }, { "name": "D-xylose metabolic process", "id": "GO:0042732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042732", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "pmid": "" }, { "name": "D-xylulokinase activity", "id": "GO:0004856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004856", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ6", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10964", "name": "", "equation": "D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ6-1" ], "evidence": [ { "id": "10964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10964" } ] }, { "id": "R-BTA-5662466", "name": "XYLB phosphorylates D-xylulose", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-5661281" ], "output_participant_list": [ "R-ALL-29790" ], "enzyme_list": [ "Q3SYZ6-1" ], "evidence": [ { "id": "R-BTA-5662466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5662466" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29790", "participant_name": "XY5P [cytosol]", "crossref": [ { "id": "ZINC000030320708", "database": "ZINC", "url": "" }, { "id": "57737", "database": "ChEBI", "url": "" }, { "id": "C00231", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-5661281", "participant_name": "D-xylulose [cytosol]", "crossref": [ { "id": "17140", "database": "ChEBI", "url": "" }, { "id": "C00310", "database": "COMPOUND", "url": "" }, { "id": "ZINC000100028356", "database": "ZINC", "url": "" }, { "id": "HMDB0001644", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q3SYZ6", "gene_name": "XYLB", "activity": [ { "ec_number": "2.7.1.17", "activity": "D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+).", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ] }, { "ec_number": "2.7.1.17", "activity": "", "evidence": [ { "id": "Q3SYZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYZ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 490, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYZ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYZ6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.17", "ec_name": "D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.17" }, { "id": "2.7.1.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 338, "end_pos": 340 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ01-1", "uniprot_ac": "Q3SZ01", "uniprot_id": "SH3Y1_BOVIN", "mass": { "chemical_mass": 37065.0, "monoisotopic_mass": 37065.0 }, "refseq": { "ac": "NP_001029779", "name": "SH3 domain-containing YSC84-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779" }, "gene_names": [ { "name": "SH3YL1", "type": "recommended", "evidence": [ { "id": "Q3SZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" } ] }, { "name": "SH3YL1", "type": "synonym", "evidence": [ { "id": "NP_001029779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779" } ] } ], "protein_names": [ { "name": "SH3 domain-containing YSC84-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3SZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain containing, Ysc84-like 1", "type": "synonym", "evidence": [ { "id": "NP_001029779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779" } ] }, { "name": "SH3 domain-containing YSC84-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779" } ] }, { "name": "Sh3 domain YSC-like 1", "type": "synonym", "evidence": [ { "id": "NP_001029779", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ01", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH3YL1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01", "locus": { "chromosome": "8", "start_pos": 112825612, "end_pos": 112763373, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020495", "url": "https://www.ensembl.org/id/ENSBTAG00000020495" } ] } } ], "crossref": [ { "id": "Q3SZ01", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020495", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020495", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11525", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11525", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11841", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11841", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534337", "url": "https://www.ncbi.nlm.nih.gov/gene/534337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051702", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051702", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SNCKARN", "url": "https://omabrowser.org/oma/group/SNCKARN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ01", "url": "https://www.orthodb.org/?gene=Q3SZ01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15629", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15629", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15629:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15629:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029779", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ01", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ01-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAILSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFELGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDITRPAQAEDLYEVLDSFTEKYEIEGQRVNARRAAREQKKASAKLPPKPSSRPEQSSAQVQLSSGSQSSRNEYNLYPELSSYRERVGNSNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGRTGIFPANYVTMN", "length": 341, "header": "sp|Q3SZ01-1|SH3Y1_BOVIN Isoform 1 of SH3 domain-containing YSC84-like protein 1 OS=Bos taurus OX=9913 GN=SH3YL1 PE=2 SV=1 CANONICAL=Q3SZ01-1" }, "isoforms": [ { "isoform_ac": "Q3SZ01-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01/entry#Q3SZ01-1", "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAILSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFELGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDITRPAQAEDLYEVLDSFTEKYEIEGQRVNARRAAREQKKASAKLPPKPSSRPEQSSAQVQLSSGSQSSRNEYNLYPELSSYRERVGNSNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGRTGIFPANYVTMN", "length": 341, "header": "sp|Q3SZ01-1|SH3Y1_BOVIN Isoform 1 of SH3 domain-containing YSC84-like protein 1 OS=Bos taurus OX=9913 GN=SH3YL1 PE=2 SV=1 CANONICAL=Q3SZ01-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534337", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UN95-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "SH3YL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAILSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFELGIEVSDLVIILNYGRAVEAFAKGGNLTLGGNCTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDVRAYDILFGDIPRPAQAEDLYEVLDSFTEKYESEGQRINARKAAREQKKAQAKELPPKPLSRPQQSSAQVQLNSGSQSNRNEYKLYPELPSYHERVGSLNQPTEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGELRGQTGIFPANYVTMN", "length": 342 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XHH4-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "SH3YL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDLWSDTTCMYYWEALLLINLQMVGVDTSKIVNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPPHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPNGTWSAPSAIGIAGLGGGFEIGIEVSDLVIILNHERAVEAFAKGGNLTLGGNLTVAIGPLGRNLEGDVALRSSAAVYTYCKSRGLFAGVSLEGTCLIERKETNRKFYGQDIRASAILLGDVPFPAQAEDLYETLASFIEVYENEEQRNNPGKAVNDPPGRPSRPEPHKPSVRPTPPAKKNSNKLYPELPSDYASLSNSTSNPVEVTALYSFEGQQPGDLTFKAGDKIIVTTKTGSQFDWWEGRIGGQTGIFPANYVAISND", "length": 365 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7GA36-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "Sh3yl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLKYILKLDVFSPSVVCFFNLSVNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDKAVEAFAKGGNLTLGGNFTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNKKFYCQDIRAYDILFGDVPQPAQAEDLYEILNSFTEKYENEGQRINLRKVAREQRKAKELPPKPSSRPQQSRAPVQLNSGSQSNGNGYKLYPELSSYHEKNGSLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN", "length": 363 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0BNA1-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "Sh3yl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNFTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDVPQPAQAEDLYEILNSFTEKYETEGQRINLKKVAREQRKAKELPPKPSSRPQPSRPPVQLNAGSQSNRNEYKLYPELSSYHEKTGSLSQPIEVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN", "length": 340 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O08641-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "Sh3yl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNFTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDVPQPAQAEDLYEILNSFTEKYETEGQRINLKKVAREQRKAKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPIEVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN", "length": 340 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P43603-1", "protein_name": "LAS seventeen-binding protein 3", "gene_name": "LSB3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGINNPIPRSLKSETKKAAKILASFVKPNQVFGADQVIPPDVLKRAKGLAIITILKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGIELTDFVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLGRSAEAAASASAGGVAAVFAYSKSKGLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSGRIRPPPAVDPLFRVLESRAFNYRPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASSTRPNTRSTRRRAQSGSRYTFDDDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSYYASHRRSGTAQSRARSSRNRWADDEYDDYDDDYESGYRRGNGRDRTKDREVDDLSNRFSKSRISSASTPQTSQGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV", "length": 459 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q96HL8-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "SH3YL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAILSVIKAGFLVTARGGSGIVVARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN", "length": 342 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WFC4-1", "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "sh3yl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNNPIPANLKSEAKKAAKILREFTEISNRMGPDKLIPAHVIAKAQGLAILSVFKAGFMITARGGSGIVIARLADGSWSAPSAIGIAGLGGGFEIGLESSDFVIILNQRRAVEAFSKGGNLTLGGNFTVAVGPLGRNVEADVAVRSTAAVYSYCKSRGLYAGVSLVGSYLIERKDTNRKFYGKDIRASAILNGDVEPPPEAYDLYTILQDYTEKYTTEWQNKHMRSSSKMSSAPARPRPPTQKSASSYTPRTQAPPAVKPALYPNLNSWDTGSDQASGGALVVTAVHPFTGQQPGDLSFNAGDRITVVTKTDSQYDWWEGELKGQVGIFPANFVSYS", "length": 336 }, "evidence": [ { "id": "Q3SZ01", "url": "https://omabrowser.org/oma/group/Q3SZ01/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of ruffle assembly", "id": "GO:1900027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900027", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ01", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ01", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ01", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ01" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ01" }, { "id": "PRU00192", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000255", "start_pos": 282, "end_pos": 341, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 125, "end_pos": 127 }, { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ07-1", "uniprot_ac": "Q3SZ07", "uniprot_id": "OVCA2_BOVIN", "mass": { "chemical_mass": 24168.0, "monoisotopic_mass": 24168.0 }, "refseq": { "ac": "NP_001029773", "name": "esterase OVCA2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" }, "gene_names": [ { "name": "OVCA2", "type": "recommended", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ] }, { "name": "OVCA2", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" } ] } ], "protein_names": [ { "name": "Esterase OVCA2", "type": "recommended", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.1", "type": "synonym", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07/entry#names_and_taxonomy" } ] }, { "name": "OVCA2 serine hydrolase domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" }, { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07/entry#names_and_taxonomy" } ] }, { "name": "Ovarian cancer-associated gene 2 protein homolog", "type": "synonym", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07/entry#names_and_taxonomy" } ] }, { "name": "candidate tumor suppressor in ovarian cancer 2", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" } ] }, { "name": "esterase OVCA2", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" } ] }, { "name": "ovarian cancer-associated gene 2 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" } ] }, { "name": "ovarian tumor suppressor candidate 2", "type": "synonym", "evidence": [ { "id": "NP_001029773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773" } ] } ], "function": [ { "annotation": "Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07#function" }, { "database": "UniProtKB", "id": "Q8WZ82", "url": "https://www.uniprot.org/uniprotkb/Q8WZ82#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OVCA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07", "locus": { "chromosome": "19", "start_pos": 23065876, "end_pos": 23064483, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047926", "url": "https://www.ensembl.org/id/ENSBTAG00000047926" } ] } } ], "crossref": [ { "id": "Q3SZ07", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ07", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047926", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047926", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513845", "url": "https://www.ncbi.nlm.nih.gov/gene/513845", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513845", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513845", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EEPRGWW", "url": "https://omabrowser.org/oma/group/EEPRGWW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ07", "url": "https://www.orthodb.org/?gene=Q3SZ07", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48070:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48070:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03959", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03959", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029773", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21164", "url": "https://www.rhea-db.org/rhea/21164", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ07-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAQPLLRILCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVVDAAGSEGARPDSGPCPPEEQPQGWWFSEQEADVFLALEEPTACRGLEEALETVAQALNKLGPFDGILGFSQGAALAALVCALGQGGDPRFPLPRFVILVSGFCPRGLGLMEPIMQGPLSLPSLHVFGDTDGVIPSQESMQLCSRFDGAVTLTHSGGHFIPAAAPQRQAYLKFLDQFAD", "length": 227, "header": "sp|Q3SZ07-1|OVCA2_BOVIN Isoform 1 of Esterase OVCA2 OS=Bos taurus OX=9913 GN=OVCA2 PE=2 SV=1 CANONICAL=Q3SZ07-1" }, "isoforms": [ { "isoform_ac": "Q3SZ07-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07/entry#Q3SZ07-1", "sequence": { "sequence": "MAAQPLLRILCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVVDAAGSEGARPDSGPCPPEEQPQGWWFSEQEADVFLALEEPTACRGLEEALETVAQALNKLGPFDGILGFSQGAALAALVCALGQGGDPRFPLPRFVILVSGFCPRGLGLMEPIMQGPLSLPSLHVFGDTDGVIPSQESMQLCSRFDGAVTLTHSGGHFIPAAAPQRQAYLKFLDQFAD", "length": 227, "header": "sp|Q3SZ07-1|OVCA2_BOVIN Isoform 1 of Esterase OVCA2 OS=Bos taurus OX=9913 GN=OVCA2 PE=2 SV=1 CANONICAL=Q3SZ07-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:513845", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513845", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MHB7-1", "protein_name": "Esterase OVCA2", "gene_name": "Ovca2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAARQPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPEAAAPEGAGPDSGPGAPEEQPRGWWFSEQEADVFYALEEPTACRGLEKALETVAQALDTLGPFDGLLGFSQGAALAAFVCALGQAGDLRFPVPRFLILVSGFWPRGLGFKESILQSPLSLPSLHVFGDTDRIIPPQESMQLASQFLGAVTLTHSGGHFIPAAATQRQAYLKFLDQFAE", "length": 227 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q503Y4-1", "protein_name": "Esterase OVCA2", "gene_name": "ovca2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAVPLRILCIHGYRQNGNSFREKTGALRKLLKKQVELVFISAPHQVPAIQEENCGTNQQSQTVSVGDEDQRGWWFSDVQARSFNAKQDCESSLGLEESIEAVKAALKDLGPFSGILGFSQGAALVAMLCALQEQKLEPDFNFRFAILVAGFRSACLEHQRFYEGPVITIPSLHVFGQDDRVIPEEMSRDLLPAFDGAQVLLHPGGHFVPAASSHRQTYQDFLKRFQ", "length": 227 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8WZ82-1", "protein_name": "Esterase OVCA2", "gene_name": "OVCA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE", "length": 227 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99369-1", "protein_name": "Family of serine hydrolases 3", "gene_name": "FSH3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSEKKKVLMLHGFVQSDKIFSAKTGGLRKNLKKLGYDLYYPCAPHSIDKKALFQSESEKGRDAAKEFNTSATSDEVYGWFFRNPESFNSFQIDQKVFNYLRNYVLENGPFDGVIGFSQGAGLGGYLVTDFNRILNLTDEQQPALKFFISFSGFKLEDQSYQKEYHRIIQVPSLHVRGELDEVVAESRIMALYESWPDNKRTLLVHPGAHFVPNSKPFVSQVCNWIQGITSKEGQEHNAQPEVDRKQFDKPQLEDDLLDMIDSLGKL", "length": 266 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9D7E3-1", "protein_name": "Esterase OVCA2", "gene_name": "Ovca2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARQTLRVLCLAGFRQSERGFREKTGALRKTLRGRAELVCLSGPHPVPEAAAPEGSCPDSGPCSPEEQPRGWWFSEEEADVFSALEESTVCRGLQEALETVARALDTLGPFDGLLGFSQGAALAAYVCALGQAGDPRFPLPRFIILVSGFCPRGLKEPILQSPMSLPSLHVFGDTDRVIPSQESMQLASRFLGAVTLTHSGGHFIPAAASQRQAYLKFLDQFAE", "length": 225 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VDL1-1", "protein_name": "Esterase CG5412", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTNNDAAVEAAGSSRASSSKQQLKLEITEKVRVLCLHGYRQNGEAFKNKLGSFRKFANKYAEFVFITAPHVAKALESAAEPVPEQRSWWANKDDGSFKGTNKGGPAFGFQESLRCVEEAWRTQGPFQGLLGFSQGACFVGLICGLAKKKLTSIRPEFAVLASGFLSGSLVHMSAYEEAISIPTLHIYGQTDEIIPKEMSESLAARFKNAEVLEHSGGHYFPATAQQKQTFINFFQDRLQEYLEHEELQQSGNASFVDSGAEDDNDAEVAAMTAELDESD", "length": 279 }, "evidence": [ { "id": "Q3SZ07", "url": "https://omabrowser.org/oma/group/Q3SZ07/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ], "pmid": "" }, { "name": "carboxylesterase activity", "id": "GO:0106435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106435", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ07", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21164", "name": "", "equation": "a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZ07-1" ], "evidence": [ { "id": "21164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21164" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q3SZ07", "gene_name": "OVCA2", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = an alcohol + a carboxylate + H(+).", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q3SZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ07" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ07-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 227, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ07-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ07" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.1", "ec_name": "a carboxylic ester + H2O = an alcohol + a carboxylate + H(+).", "evidence": [ { "id": "3.1.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1" }, { "id": "3.1.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ10-1", "uniprot_ac": "Q3SZ10", "uniprot_id": "RL3L_BOVIN", "mass": { "chemical_mass": 46410.0, "monoisotopic_mass": 46410.0 }, "refseq": { "ac": "NP_001030578", "name": "large ribosomal subunit protein uL3-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030578" }, "gene_names": [ { "name": "RPL3L", "type": "recommended", "evidence": [ { "id": "Q3SZ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ] }, { "name": "RPL3L", "type": "synonym", "evidence": [ { "id": "NP_001030578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030578" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL3-like", "type": "recommended", "evidence": [ { "id": "Q3SZ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L3-like", "type": "synonym", "evidence": [ { "id": "NP_001030578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030578" }, { "id": "Q3SZ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL3-like", "type": "synonym", "evidence": [ { "id": "NP_001030578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030578" } ] } ], "function": [ { "annotation": "Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10#function" }, { "database": "UniProtKB", "id": "E9PWZ3", "url": "https://www.uniprot.org/uniprotkb/E9PWZ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL3L", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10", "locus": { "chromosome": "25", "start_pos": 1507603, "end_pos": 1514414, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009533", "url": "https://www.ensembl.org/id/ENSBTAG00000009533" } ] } } ], "crossref": [ { "id": "Q3SZ10", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009533", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009533", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618440", "url": "https://www.ncbi.nlm.nih.gov/gene/618440", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618440", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618440", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVEDGKM", "url": "https://omabrowser.org/oma/group/HVEDGKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHZ3", "url": "https://www.orthodb.org/?gene=A0A3Q1MHZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ10", "url": "https://www.orthodb.org/?gene=Q3SZ10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11363", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11363", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11363:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11363:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030578", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHZ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ10-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDADGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEVQLNGGTVAEKVAWAQARLEKQVPVHSVFSQNEIIDVIAVTKGRGIKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMEDGKVVKNNASTSYDVTDKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQALENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKEKPETSGDL", "length": 407, "header": "sp|Q3SZ10-1|RL3L_BOVIN Isoform 1 of Large ribosomal subunit protein uL3-like OS=Bos taurus OX=9913 GN=RPL3L PE=2 SV=3 CANONICAL=Q3SZ10-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHZ3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10/entry#A0A3Q1MHZ3-1", "sequence": { "sequence": "MQARRTTGRSLGSVAHFQSGLWDRLAAPPGETPALTYLPSRPQSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDADGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEVQLNGGTVAEKVAWAQARLEKQVPVHSVFSQNEIIDVIAVTKGRGIKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMEDGKVVKNNASTSYDVTDKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQALENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKEKPETSGDL", "length": 449, "header": "tr|A0A3Q1MHZ3-1|A0A3Q1MHZ3_BOVIN Computationally mapped isoform of Ribosomal protein L3 like OS=Bos taurus OX=9913 GN=RPL3L PE=3 SV=1 CANONICAL=Q3SZ10-1" }, "locus": { "chromosome": "25", "start_pos": 1514056, "end_pos": 1507687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000071280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070322.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070322.1" } ] } }, { "isoform_ac": "Q3SZ10-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10/entry#Q3SZ10-1", "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDADGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEVQLNGGTVAEKVAWAQARLEKQVPVHSVFSQNEIIDVIAVTKGRGIKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMEDGKVVKNNASTSYDVTDKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQALENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKEKPETSGDL", "length": 407, "header": "sp|Q3SZ10-1|RL3L_BOVIN Isoform 1 of Large ribosomal subunit protein uL3-like OS=Bos taurus OX=9913 GN=RPL3L PE=2 SV=3 CANONICAL=Q3SZ10-1" }, "locus": { "chromosome": "25", "start_pos": 1514394, "end_pos": 1507687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012541.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012541.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012541.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012541.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618440", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618440", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BKN5-1", "protein_name": "60S ribosomal protein L3-like", "gene_name": "RPL3L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSRRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYRDWHKSKKKAFTKACRRWRDTDGKKQLQRDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMSDGKMVKNNASTSYDMTDKSITPLGGFPRYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRRALENVELKFIDTTSKFGHGRFQTAQEKRIFMGPQKKHLEKETPETSGDL", "length": 407 }, "evidence": [ { "id": "Q3SZ10", "url": "https://omabrowser.org/oma/group/Q3SZ10/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A9G1-1", "protein_name": "60S ribosomal protein L3-like", "gene_name": "Rpl3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSRRHRGKVKSWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDADGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMEDGKMVRNNASTSYDVTDKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRRALENIELKFIDTTSKFGHGCFQTAQEKRAFMGPQKKHLEKEKPETSGNV", "length": 407 }, "evidence": [ { "id": "Q3SZ10", "url": "https://omabrowser.org/oma/group/Q3SZ10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PWZ3-1", "protein_name": "Large ribosomal subunit protein uL3-like", "gene_name": "Rpl3l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSRRHRGKVKSWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDADGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWVQARMEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIYRIGRGLHMEDGKMVRNNASTSYDVTDKSITPLGGFPHYGEVNNDFIMLKGCIAGTKKRVITLRKSLLVHHSRRALENIELKFIDTTSKFGHGCFQTAQEKRAFMGPQKKHLEKEKPETLGNM", "length": 407 }, "evidence": [ { "id": "Q3SZ10", "url": "https://omabrowser.org/oma/group/Q3SZ10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92901-1", "protein_name": "Ribosomal protein uL3-like", "gene_name": "RPL3L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDTDGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIFRIGRGPHMEDGKLVKNNASTSYDVTAKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQAVENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKETPETSGDL", "length": 407 }, "evidence": [ { "id": "Q3SZ10", "url": "https://omabrowser.org/oma/group/Q3SZ10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" }, { "name": "regulation of striated muscle tissue development", "id": "GO:0016202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016202", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" }, { "name": "negative regulation of myotube differentiation", "id": "GO:0010832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010832", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ10", "url": "https://www.uniprot.org/uniprotkb/Q3SZ10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ10-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 407, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ10-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ10" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 302, "end_pos": 304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ12-1", "uniprot_ac": "Q3SZ12", "uniprot_id": "RLP24_BOVIN", "mass": { "chemical_mass": 19597.0, "monoisotopic_mass": 19597.0 }, "refseq": { "ac": "NP_001073824", "name": "probable ribosome biogenesis protein RLP24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824" }, "gene_names": [ { "name": "RSL24D1", "type": "recommended", "evidence": [ { "id": "Q3SZ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12" } ] }, { "name": "RLP24", "type": "synonym", "evidence": [ { "id": "NP_001073824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824" } ] }, { "name": "RSL24D1", "type": "synonym", "evidence": [ { "id": "NP_001073824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824" } ] } ], "protein_names": [ { "name": "Probable ribosome biogenesis protein RLP24", "type": "recommended", "evidence": [ { "id": "Q3SZ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal L24 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q3SZ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12/entry#names_and_taxonomy" } ] }, { "name": "probable ribosome biogenesis protein RLP24", "type": "synonym", "evidence": [ { "id": "NP_001073824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824" } ] }, { "name": "ribosomal L24 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001073824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824" } ] } ], "function": [ { "annotation": "Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12#function" }, { "database": "UniProtKB", "id": "Q07915", "url": "https://www.uniprot.org/uniprotkb/Q07915#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSL24D1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12", "locus": { "chromosome": "10", "start_pos": 55113416, "end_pos": 55099533, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001342", "url": "https://www.ensembl.org/id/ENSBTAG00000001342" } ] } } ], "crossref": [ { "id": "Q3SZ12", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001342", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001342", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00472", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00472", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783948", "url": "https://www.ncbi.nlm.nih.gov/gene/783948", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783948", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783948", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCYFCSG", "url": "https://omabrowser.org/oma/group/TCYFCSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ12", "url": "https://www.orthodb.org/?gene=Q3SZ12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073824", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ12-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDVKEVKQNIHLIRAPLAGKGKQLEDKMVQKLQEDVDMEDVS", "length": 163, "header": "sp|Q3SZ12-1|RLP24_BOVIN Isoform 1 of Probable ribosome biogenesis protein RLP24 OS=Bos taurus OX=9913 GN=RSL24D1 PE=2 SV=1 CANONICAL=Q3SZ12-1" }, "isoforms": [ { "isoform_ac": "Q3SZ12-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12/entry#Q3SZ12-1", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDVKEVKQNIHLIRAPLAGKGKQLEDKMVQKLQEDVDMEDVS", "length": 163, "header": "sp|Q3SZ12-1|RLP24_BOVIN Isoform 1 of Probable ribosome biogenesis protein RLP24 OS=Bos taurus OX=9913 GN=RSL24D1 PE=2 SV=1 CANONICAL=Q3SZ12-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783948", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783948", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZM22-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "RSL24D1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGVMFVRNDCKIFRFCKSKCHKNFKKKRNPRKIRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTVDAMKRVEEIKQKRQARFIMNRLKKSKELQKAEDIKEVKQNIHLLRAPHAGKPKQLEEKMVQKLQEDVAMEEDS", "length": 163 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GRJ5-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "Rsl24d1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWSKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEDTS", "length": 163 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O22165-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "RPL24C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRLEKCWFCSSTIYPGHGIQFVRNDAKIFRFCRSKCHKNFKMKRNPRKVKWTKAFRAAHGKDMTKDTTFEFEKKRNRPERYDRNVTENTLMAIKKIAKIRTAREAKHIENRLKPNKQKKLNDDMKELDQNIHMVQAPGAQKIKVDVSEKKSVQNEAMEE", "length": 159 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q7ZTZ2-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "rsl24d1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRIEKCYFCSAPVYPGHGMMFVRNDCKVFRFCRSKCHKNFKKKRNPRKTRWTKAFRKSAGKELTVDNSLEFEKRRNTPVKYNRELWSKTVEAMRKVESIKHKRQARFIMNRLKKGKELEKAADISEVKKNIHLIKAPHAGQAKQLEDKMVQKLAEDVEMDE", "length": 161 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q86B05-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "rlp24", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRIEKCYFCSGPVYPGHGVMFVRNDCKQFRFCRSKCHKNFKLKRNPRKTRWTKAFRKLNGKEMTVDKTLEFEKKRNRPVKYDRELINNTIIAMARVQKIKERREKTFYKNRMEGVKGMQKKQKLKEINQNLSLIRGPSALNKLQERIKNNAEKIEQLTTTKMQS", "length": 164 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q99L28-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "Rsl24d1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEEAS", "length": 163 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHA3-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "RSL24D1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPIKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEDAP", "length": 163 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VGN9-1", "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "RpL24-like", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRIQTCYFCSSKIYPGHGVQFVRNDCKVFKFCRGKCHKAFKRKKNPRKVGWTKAYRKAAGKELAIDPSFEFEKRRNVPMKYSRETWQKGLEAIKRVTEIKEKRTSHFVMERLRKGRQVEIQMDVKDVQRNMSLIRSPAAGLKQRRAQEAAEEAALMEEDLPEEKITYVDARELEKKLEEGMGVEDLEMLEA", "length": 191 }, "evidence": [ { "id": "Q3SZ12", "url": "https://omabrowser.org/oma/group/Q3SZ12/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ12", "url": "https://www.uniprot.org/uniprotkb/Q3SZ12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ12" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ16-1", "uniprot_ac": "Q3SZ16", "uniprot_id": "IAH1_BOVIN", "mass": { "chemical_mass": 27579.0, "monoisotopic_mass": 27579.0 }, "refseq": { "ac": "NP_001029930", "name": "isoamyl acetate-hydrolyzing esterase 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029930" }, "gene_names": [ { "name": "IAH1", "type": "recommended", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "name": "IAH1", "type": "synonym", "evidence": [ { "id": "NP_001029930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029930" } ] } ], "protein_names": [ { "name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "type": "recommended", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#names_and_taxonomy" } ] }, { "name": "isoamyl acetate-hydrolyzing esterase 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029930" } ] } ], "function": [ { "annotation": "Probable lipase.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16#function" }, { "database": "UniProtKB", "id": "A0AAA9SDL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL8#function" }, { "database": "UniProtKB", "id": "ARBA00024673", "url": "https://www.uniprot.org/uniprotkb/ARBA00024673#function" }, { "database": "UniProtKB", "id": "A0AAA9T503", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T503#function" }, { "database": "UniProtKB", "id": "A0AAF6ZB27", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB27#function" }, { "database": "UniProtKB", "id": "A0AAA9TS64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS64#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IAH1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16", "locus": { "chromosome": "11", "start_pos": 87961968, "end_pos": 87973214, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001140", "url": "https://www.ensembl.org/id/ENSBTAG00000001140" } ] } } ], "crossref": [ { "id": "Q3SZ16", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001140", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001140", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01838", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01838", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614320", "url": "https://www.ncbi.nlm.nih.gov/gene/614320", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614320", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614320", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VIWPKVI", "url": "https://omabrowser.org/oma/group/VIWPKVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ16", "url": "https://www.orthodb.org/?gene=Q3SZ16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14209", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14209", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14209:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14209:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00657", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00657", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17777", "url": "https://www.rhea-db.org/rhea/17777", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40479", "url": "https://www.rhea-db.org/rhea/40479", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41704", "url": "https://www.rhea-db.org/rhea/41704", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T503", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T503", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T503-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T503-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB27", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ16-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALCEAVASGSPLVWPRVLLFGDSITQFSFQQGGWGASLADMLVRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPFLLPYWRDIAEARPELSLLGDGDH", "length": 249, "header": "sp|Q3SZ16-1|IAH1_BOVIN Isoform 1 of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=2 SV=1 CANONICAL=Q3SZ16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDL8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#A0AAA9SDL8-1", "sequence": { "sequence": "MALCEAVASGSPLVWPRVLLFGDSITQFSFQQGGWGASLADMLVRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQQLASCSGKPSDRSWHTVKQMSSKWSMAWESTAARERGWRLSACHVRKNFPGV", "length": 241, "header": "tr|A0AAA9SDL8-1|A0AAA9SDL8_BOVIN Computationally mapped isoform of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=3 SV=1 CANONICAL=Q3SZ16-1" }, "locus": { "chromosome": "11", "start_pos": 87973179, "end_pos": 87962965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130962.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130962.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081661.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081661.1" } ] } }, { "isoform_ac": "A0AAA9T503-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#A0AAA9T503-1", "sequence": { "sequence": "MEGVKTSNMFPCLLPKFSFQQGGWGASLADMLVRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPFLLPYWRDIAEARPELSLLGDGDH", "length": 238, "header": "tr|A0AAA9T503-1|A0AAA9T503_BOVIN Computationally mapped isoform of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=3 SV=1 CANONICAL=Q3SZ16-1" }, "locus": { "chromosome": "11", "start_pos": 87972080, "end_pos": 87962202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126358.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126358.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091794.1" } ] } }, { "isoform_ac": "A0AAA9TS64-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#A0AAA9TS64-1", "sequence": { "sequence": "SSPPTRHGTSESAQPLLHNLCHGGLGRLPWVSEPGRSPTCLSPALPHPHGEARAVSRRALPASSQTHPLPHQSVAAGGRKQFSAHNSPLTFFFHFRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPFLLPYWRDIAEARPELSLLGDGDH", "length": 300, "header": "tr|A0AAA9TS64-1|A0AAA9TS64_BOVIN Computationally mapped isoform of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=3 SV=1 CANONICAL=Q3SZ16-1" }, "locus": { "chromosome": "11", "start_pos": 87966692, "end_pos": 87962202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110106.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110106.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099319.1" } ] } }, { "isoform_ac": "A0AAF6ZB27-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#A0AAF6ZB27-1", "sequence": { "sequence": "IDFSFQQGGWGASLADMLVRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPFLLPYWRDIAEARPELSLLGDGDH", "length": 224, "header": "tr|A0AAF6ZB27-1|A0AAF6ZB27_BOVIN Computationally mapped isoform of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=3 SV=1 CANONICAL=Q3SZ16-1" }, "locus": { "chromosome": "11", "start_pos": 87971674, "end_pos": 87962202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032849.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032849.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032777.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032777.3" } ] } }, { "isoform_ac": "Q3SZ16-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16/entry#Q3SZ16-1", "sequence": { "sequence": "MALCEAVASGSPLVWPRVLLFGDSITQFSFQQGGWGASLADMLVRKCDVLNRGFSGYNTRWAKIILPRLVRKGSGLDSPVAVTIFFGANDSALKDENPKQHVPLEEFVANLRSMVRYLRSVDVPEGRLILITPPPLCEAAWAQECLQQGCKLNRLNSVVGEYARACLQVAQDCGADALDLWSLMQKDGQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPFLLPYWRDIAEARPELSLLGDGDH", "length": 249, "header": "sp|Q3SZ16-1|IAH1_BOVIN Isoform 1 of Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus OX=9913 GN=IAH1 PE=2 SV=1 CANONICAL=Q3SZ16-1" }, "locus": { "chromosome": "11", "start_pos": 87973179, "end_pos": 87962202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143328.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143328.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105693.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614320", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614320", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SA96-1", "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "IAH1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "LDFSFQQGGWGASLADRLVRKCDVLNRGFSGYNTRWANIILPRLLRNGDGSDSPVAVTVFFGANDSALKDENPKQHVPLAEFAANLKSMVQQLRAAGVPAAGLVLITPPPLCEAAWEQECLRQGSKLNRLNAVVGEYARACVQVAQDCGTDALDLWTLMQKDNQDFSSYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPLRFPYWRDVAEATPERSLLGGGDQ", "length": 224 }, "evidence": [ { "id": "Q3SZ16", "url": "https://omabrowser.org/oma/group/Q3SZ16/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2TAA2-1", "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "IAH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALCEAAGCGSALLWPRLLLFGDSITQFSFQQGGWGASLADRLVRKCDVLNRGFSGYNTRWAKIILPRLIRKGNSLDIPVAVTIFFGANDSALKDENPKQHIPLEEYAANLKSMVQYLKSVDIPENRVILITPTPLCETAWEEQCIIQGCKLNRLNSVVGEYANACLQVAQDCGTDVLDLWTLMQDSQDFSSYLSDGLHLSPKGNEFLFSHLWPLIEKKVSSLPLLLPYWRDVAEAKPELSLLGDGDH", "length": 248 }, "evidence": [ { "id": "Q3SZ16", "url": "https://omabrowser.org/oma/group/Q3SZ16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q503L4-1", "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "iah1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSALKRVIWPQIILFGDSITQFAFQANGWGSELCHKLERKCDVINRGLSGYNTRWAKIVLPRIVPVSDAPISAVTVFFGANDCALEDKNPTQHVPLQEFSENLKDIVRFLVSKGVSNDNIIFITPPPLLEADWEKECLLKGSPLNRLNSVAGQYAQACVQAAGESGVDVLDLWTLMQKDGQDFSVYLSDGLHLSDKGNQFVAEHLWTLLERRVSDLPFILPYWGDVDPKCPESSLLCD", "length": 238 }, "evidence": [ { "id": "Q3SZ16", "url": "https://omabrowser.org/oma/group/Q3SZ16/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q711G3-1", "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "Iah1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLCELAASGSSLLWPRVLLFGDSITQFSFQQGGWGTLLADRLVRKCDVLNRGFSGYNTRWAKIILPRIIRKGAGLENPVAVTIFFGANDSTLKDENPKQHVPLDEYSANLRDMVQYLRSVDIPKERVILITPPPLCEAAWEKECILKGCKLNRLNVAVGEYAKACLQVARDCGTDVLDLWTLMQKDNQDFSSYLSDGLHLSPLGNEFLFFHLWPLLDKKVSSLPRLLPDWKDVEETKPELSLLGDGDH", "length": 249 }, "evidence": [ { "id": "Q3SZ16", "url": "https://omabrowser.org/oma/group/Q3SZ16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DB29-1", "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "Iah1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLCERAASGSALLWPRVLLFGDSITQFSFQQGGWGSLLADRLVRKCDVLNRGFSGYNTRWAKIILPRLIRKGPGMENPVAVTIFFGANDSSLKDENPKQHVPLDEYSANLRDMVQYLRSVDVPRERVILITPPPLCEAAWEKECVLKGCKLNRLNSVVGEYANACLQVARDCGTDVLDLWTLMQKDSQDFSSYLSDGLHLSPMGNEFLFLNLCPLLDKKVSSLPWLLPYWKDVEEAKPELSLLGDGDY", "length": 249 }, "evidence": [ { "id": "Q3SZ16", "url": "https://omabrowser.org/oma/group/Q3SZ16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity, acting on ester bonds", "id": "GO:0016788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ], "pmid": "" }, { "name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "id": "GO:0003847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003847", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ16", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17777", "name": "", "equation": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "F1MGH2-1" ], "evidence": [ { "id": "17777", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17777" } ] }, { "id": "40479", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q0VC00-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "E1BB89-1" ], "evidence": [ { "id": "40479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40479" } ] }, { "id": "41704", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF7ABT5-1", "P68401-1", "Q29460-1", "Q3SZ16-1" ], "evidence": [ { "id": "41704", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41704" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF7ABT5", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "F1MGH2", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P79106", "gene_name": "PAFAH2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine.", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] } ] }, { "uniprot_ac": "Q0VC00", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] } ] }, { "uniprot_ac": "Q28017", "gene_name": "PLA2G7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] } ] }, { "uniprot_ac": "Q29460", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] } ] }, { "uniprot_ac": "Q3SZ16", "gene_name": "IAH1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ16-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ16" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.47", "ec_name": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "3.1.1.47", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47" }, { "id": "3.1.1.47", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.47" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ22-1", "uniprot_ac": "Q3SZ22", "uniprot_id": "RM46_BOVIN", "mass": { "chemical_mass": 31726.0, "monoisotopic_mass": 31726.0 }, "refseq": { "ac": "NP_001029884", "name": "large ribosomal subunit protein mL46", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" }, "gene_names": [ { "name": "MRPL46", "type": "recommended", "evidence": [ { "id": "Q3SZ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22" } ] }, { "name": "MRPL46", "type": "synonym", "evidence": [ { "id": "NP_001029884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL46", "type": "recommended", "evidence": [ { "id": "Q3SZ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L46, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" }, { "id": "Q3SZ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22/entry#names_and_taxonomy" } ] }, { "name": "L46mt", "type": "synonym", "evidence": [ { "id": "NP_001029884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" }, { "id": "Q3SZ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22/entry#names_and_taxonomy" } ] }, { "name": "MRP-L46", "type": "synonym", "evidence": [ { "id": "NP_001029884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" }, { "id": "Q3SZ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL46", "type": "synonym", "evidence": [ { "id": "NP_001029884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ22", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL46", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22", "locus": { "chromosome": "21", "start_pos": 19474872, "end_pos": 19484145, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019830", "url": "https://www.ensembl.org/id/ENSBTAG00000019830" } ] } } ], "crossref": [ { "id": "Q3SZ22", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019830", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019830", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04661", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04661", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540720", "url": "https://www.ncbi.nlm.nih.gov/gene/540720", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540720", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540720", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKWDLYA", "url": "https://omabrowser.org/oma/group/EKWDLYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ22", "url": "https://www.orthodb.org/?gene=Q3SZ22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13124:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13124:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029884", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ22", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ22-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPTRRTVLGLARCWRRFESPWSLGSRSLTLAAAPSNSASPWRLLGALCLQRPPLVSKQLTPMQEEMAALLQQMEIERSLYSDHELRALDEAEQLEKKKSDLYEEKDEKNILLVQDLEDMWEQKFLQFKPGARITDADVKNDRSSLHRKLDRNLILLVKDKLGDQDVWMLPQAEWQPGETLRQTAERTLATLSENNLEAKFLGNAPCGHYKFKFPQAVRAEGSLGAKIFFFKALLLTGDFSPAVEKGRHVWASKEELGDYLKPKYLAQVRRFLLDL", "length": 277, "header": "sp|Q3SZ22-1|RM46_BOVIN Isoform 1 of Large ribosomal subunit protein mL46 OS=Bos taurus OX=9913 GN=MRPL46 PE=2 SV=1 CANONICAL=Q3SZ22-1" }, "isoforms": [ { "isoform_ac": "Q3SZ22-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22/entry#Q3SZ22-1", "sequence": { "sequence": "MAAPTRRTVLGLARCWRRFESPWSLGSRSLTLAAAPSNSASPWRLLGALCLQRPPLVSKQLTPMQEEMAALLQQMEIERSLYSDHELRALDEAEQLEKKKSDLYEEKDEKNILLVQDLEDMWEQKFLQFKPGARITDADVKNDRSSLHRKLDRNLILLVKDKLGDQDVWMLPQAEWQPGETLRQTAERTLATLSENNLEAKFLGNAPCGHYKFKFPQAVRAEGSLGAKIFFFKALLLTGDFSPAVEKGRHVWASKEELGDYLKPKYLAQVRRFLLDL", "length": 277, "header": "sp|Q3SZ22-1|RM46_BOVIN Isoform 1 of Large ribosomal subunit protein mL46 OS=Bos taurus OX=9913 GN=MRPL46 PE=2 SV=1 CANONICAL=Q3SZ22-1" }, "locus": { "chromosome": "21", "start_pos": 19484133, "end_pos": 19475019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026420.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026420.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026420.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026420.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540720", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540720", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SRT0-1", "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "MRPL46", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPVRRTMLRVVRGWRRFEGPWAHSLGSRNLALAVAPSSSSSPWRLLGALCLQRPPLVTKPLTPLQEEMADLLQQIEIERSLYSDHELRALDEAQQLAKKKSDLYEEEDEQNILLAQDLEDMWEQKFLHFKLGARLTEADKKDDRTSLHRKLDRNLILLVREKLGDQDIWMLPQSDWQPGETLRQTAERTLATLSENNMEAKFLGNAPCGHYKFKFPQAMRTETSLGAKVFFFKALLLTGDFSQAGKKGHHVWVSKEELGDYLKPKYLAQVRRFLLDL", "length": 279 }, "evidence": [ { "id": "Q3SZ22", "url": "https://omabrowser.org/oma/group/Q3SZ22/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RK00-1", "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "Mrpl46", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPIGRTLLGVAKGWRQLDRLWAGSSRGLSLEAAPSSSRSPWRLSGALCLQRPPLITKPLTPLQEEMAGLLQQVEVERSLYSDHELRALDEAQRLAKKKADLYDEEQDQDVTLAQDLEDMWEQEFLQFRPGARETEADKKNDRTSLHRKLDRNLILLVREKLGDQDLWMLPQVEWQPGETLRGTAERILATLSENNMEAKFLGNAPCGHYKFKFPKAIRTESDLGVKVFFFKALLLTGDFVQTGKKGRHVWASKEELGDYLQPKYLAQVRRFLLDL", "length": 277 }, "evidence": [ { "id": "Q3SZ22", "url": "https://omabrowser.org/oma/group/Q3SZ22/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9EQI8-1", "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "Mrpl46", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPVGRTLLGLARGWRQLDRFWAGSSRGLSLEAASSSSRSPWRLSGALCLQRPPLITKALTPLQEEMAGLLQQIEVERSLYSDHELRALDEAQRLAKKKADLYDEEQEQGITLAQDLEDMWEQAFLQFRPGARETEADKKNDRTSLHRKLDRNLVLLVREKLGDQDVWMLPQVEWQPGETLRGTAERILATLSENNMEAKFLGNAPCGHYKFKFPKAIQTESDLGVKVFFFKALLLTGDFVQAGKKSRHVWASKEELGDYLQPKYLAQVRRFLLDSDGLSCL", "length": 283 }, "evidence": [ { "id": "Q3SZ22", "url": "https://omabrowser.org/oma/group/Q3SZ22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2W6-1", "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "MRPL46", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL", "length": 279 }, "evidence": [ { "id": "Q3SZ22", "url": "https://omabrowser.org/oma/group/Q3SZ22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W086-1", "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "mRpL46", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRRIVQVGARELSRAQSSTASAEKWDLYAGVLVERLPVVSKSLNPLEKQFQDLLWRVEYENSLKSDHELKHEREIVQAELIKQGKIQVDLEDAGSKQTAQDLKDAYVEELKKFQLGSRTTPDDQANRTTSTDRCLDDTLYLLVQQKLGQQEHLILPQGKREEGESMRQTAERVLRESCGQELQVLFYGNAPVGFHKYKYPRNQRTETVGAKVFFYRASLRSGQVPENLTKFEWLPKEALNEKLTNTAYAQSVKKFLL", "length": 258 }, "evidence": [ { "id": "Q3SZ22", "url": "https://omabrowser.org/oma/group/Q3SZ22/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ22", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ22", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ22", "url": "https://www.uniprot.org/uniprotkb/Q3SZ22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 277, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ22" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ31-1", "uniprot_ac": "Q3SZ31", "uniprot_id": "APC15_BOVIN", "mass": { "chemical_mass": 14281.0, "monoisotopic_mass": 14281.0 }, "refseq": { "ac": "NP_001029415", "name": "anaphase-promoting complex subunit 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" }, "gene_names": [ { "name": "ANAPC15", "type": "recommended", "evidence": [ { "id": "Q3SZ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ] }, { "name": "ANAPC15", "type": "synonym", "evidence": [ { "id": "NP_001029415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" } ] }, { "name": "APC15", "type": "synonym", "evidence": [ { "id": "NP_001029415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" } ] }, { "name": "C15H11orf51", "type": "synonym", "evidence": [ { "id": "NP_001029415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit 15", "type": "recommended", "evidence": [ { "id": "Q3SZ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31/entry#names_and_taxonomy" } ] }, { "name": "APC15", "type": "synonym", "evidence": [ { "id": "Q3SZ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31/entry#names_and_taxonomy" } ] }, { "name": "anaphase-promoting complex subunit 15", "type": "synonym", "evidence": [ { "id": "NP_001029415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" } ] }, { "name": "protein HSPC020 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Also required for degradation of CDC20 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31#function" }, { "database": "UniProtKB", "id": "P60006", "url": "https://www.uniprot.org/uniprotkb/P60006#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANAPC15", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31", "locus": { "chromosome": "15", "start_pos": 51742236, "end_pos": 51745678, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002999", "url": "https://www.ensembl.org/id/ENSBTAG00000002999" } ] } } ], "crossref": [ { "id": "Q3SZ31", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002999", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002999", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505356", "url": "https://www.ncbi.nlm.nih.gov/gene/505356", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905242", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905242", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:505356", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505356", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EGTDQDQ", "url": "https://omabrowser.org/oma/group/EGTDQDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LW89", "url": "https://www.orthodb.org/?gene=A0A3Q1LW89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ31", "url": "https://www.orthodb.org/?gene=Q3SZ31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22526", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22526", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22526:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22526:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15243", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15243", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174048", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174048", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174084", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174154", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174184", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176407", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176407", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176412", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176412", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-179409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-179409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559582", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559582", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029415", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW89", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW89-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKM2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ31-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDEDDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 121, "header": "sp|Q3SZ31-1|APC15_BOVIN Isoform 1 of Anaphase-promoting complex subunit 15 OS=Bos taurus OX=9913 GN=ANAPC15 PE=2 SV=1 CANONICAL=Q3SZ31-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW89-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31/entry#A0A3Q1LW89-1", "sequence": { "sequence": "MRLVCPWFWRALPVRQKEVLPGRRRLPPPGALQSIAEKDNNLVPIGKPASEHYDDEEEEDEDDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 112, "header": "tr|A0A3Q1LW89-1|A0A3Q1LW89_BOVIN Computationally mapped isoform of Anaphase promoting complex subunit 15 OS=Bos taurus OX=9913 GN=ANAPC15 PE=3 SV=1 CANONICAL=Q3SZ31-1" }, "locus": { "chromosome": "15", "start_pos": 51745479, "end_pos": 51742540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070358.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070358.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061680.1" } ] } }, { "isoform_ac": "A0AAF6YKM2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31/entry#A0AAF6YKM2-1", "sequence": { "sequence": "LLVPPSLPSPEKPHSPDPPPQELPAHTPLNIKALQLIGRFLESKPHPVTQDPSLIGTTSSHSAFLPVNWPYPAAPFALSDPIRANACPNPAPAFLLVNSTIIIIISREWVVALRRWVGLSELRSLAHQYFCGGEGVLLILLNAPGSCGAMSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDEDDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 270, "header": "tr|A0AAF6YKM2-1|A0AAF6YKM2_BOVIN Computationally mapped isoform of Anaphase promoting complex subunit 15 OS=Bos taurus OX=9913 GN=ANAPC15 PE=3 SV=1 CANONICAL=Q3SZ31-1" }, "locus": { "chromosome": "15", "start_pos": 51745355, "end_pos": 51742540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003902.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003902.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003902.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003902.5" } ] } }, { "isoform_ac": "Q3SZ31-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31/entry#Q3SZ31-1", "sequence": { "sequence": "MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDEDDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 121, "header": "sp|Q3SZ31-1|APC15_BOVIN Isoform 1 of Anaphase-promoting complex subunit 15 OS=Bos taurus OX=9913 GN=ANAPC15 PE=2 SV=1 CANONICAL=Q3SZ31-1" }, "locus": { "chromosome": "1", "start_pos": 42017240, "end_pos": 42016878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151826.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151826.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104616.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104616.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101905242", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905242", "resource": "KEGG Pathway" }, { "id": "bta:505356", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505356", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-174048", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174048", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Cyclin B" }, { "id": "R-BTA-174084", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "resource": "Reactome", "description": "Autodegradation of Cdh1 by Cdh1:APC/C" }, { "id": "R-BTA-174154", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Securin" }, { "id": "R-BTA-174178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-BTA-174184", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-BTA-176407", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176407", "resource": "Reactome", "description": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" }, { "id": "R-BTA-176408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "resource": "Reactome", "description": "Regulation of APC/C activators between G1/S and early anaphase" }, { "id": "R-BTA-176409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176409", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of mitotic proteins" }, { "id": "R-BTA-176412", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176412", "resource": "Reactome", "description": "Phosphorylation of the APC/C" }, { "id": "R-BTA-179409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-179409", "resource": "Reactome", "description": "APC-Cdc20 mediated degradation of Nek2A" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2559582", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559582", "resource": "Reactome", "description": "Senescence-Associated Secretory Phenotype (SASP)" }, { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQX4-1", "protein_name": "Anaphase-promoting complex subunit 15", "gene_name": "Anapc15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPGLKLSLGAMSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 132 }, "evidence": [ { "id": "Q3SZ31", "url": "https://omabrowser.org/oma/group/Q3SZ31/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P60006-1", "protein_name": "Anaphase-promoting complex subunit 15", "gene_name": "ANAPC15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI", "length": 121 }, "evidence": [ { "id": "Q3SZ31", "url": "https://omabrowser.org/oma/group/Q3SZ31/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" }, { "name": "regulation of mitotic cell cycle spindle assembly checkpoint", "id": "GO:0090266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090266", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "anaphase-promoting complex", "id": "GO:0005680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ31", "url": "https://www.uniprot.org/uniprotkb/Q3SZ31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ31-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 121, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ31-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ31" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ43-1", "uniprot_ac": "Q3SZ43", "uniprot_id": "UB2V2_BOVIN", "mass": { "chemical_mass": 16363.0, "monoisotopic_mass": 16363.0 }, "refseq": { "ac": "NP_001029214", "name": "ubiquitin-conjugating enzyme E2 variant 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029214" }, "gene_names": [ { "name": "UBE2V2", "type": "recommended", "evidence": [ { "id": "Q3SZ43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ] }, { "name": "DDVIT1", "type": "synonym", "evidence": [ { "id": "NP_001029214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029214" } ] }, { "name": "UBE2V2", "type": "synonym", "evidence": [ { "id": "NP_001029214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029214" } ] }, { "name": "UEV2", "type": "synonym", "evidence": [ { "id": "Q3SZ43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ] } ], "protein_names": [ { "name": "Ubiquitin-conjugating enzyme E2 variant 2", "type": "recommended", "evidence": [ { "id": "Q3SZ43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-conjugating enzyme E2 variant 2", "type": "synonym", "evidence": [ { "id": "NP_001029214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029214" } ] } ], "function": [ { "annotation": "Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2V2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43", "locus": { "chromosome": "14", "start_pos": 19612894, "end_pos": 19592673, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023218", "url": "https://www.ensembl.org/id/ENSBTAG00000023218" } ] } } ], "crossref": [ { "id": "Q3SZ43", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ43", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023218", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023218", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23807", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23807", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "286803", "url": "https://www.ncbi.nlm.nih.gov/gene/286803", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286803", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286803", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWSREST", "url": "https://omabrowser.org/oma/group/NWSREST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ43", "url": "https://www.orthodb.org/?gene=Q3SZ43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24068", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24068", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029214", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWR9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWR9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ32", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ32-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIV8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIV8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNN0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNN0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRP9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRP9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ43-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 145, "header": "sp|Q3SZ43-1|UB2V2_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 variant 2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=2 SV=3 CANONICAL=Q3SZ43-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWR9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#A0A3Q1LWR9-1", "sequence": { "sequence": "MLGKGVCVLHQQHFLQDRPLSVDREVDSKHLPETHPGFIERLWHSALLMVQFLCVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 193, "header": "tr|A0A3Q1LWR9-1|A0A3Q1LWR9_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 V2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=4 SV=2 CANONICAL=Q3SZ43-1" }, "locus": { "chromosome": "14", "start_pos": 19612161, "end_pos": 19600256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077756.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077756.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059908.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059908.2" } ] } }, { "isoform_ac": "A0A452DJ32-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#A0A452DJ32-1", "sequence": { "sequence": "MTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 105, "header": "tr|A0A452DJ32-1|A0A452DJ32_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 V2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=4 SV=3 CANONICAL=Q3SZ43-1" }, "locus": { "chromosome": "14", "start_pos": 19612161, "end_pos": 19606381, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031581.5", "url": "https://www.ensembl.org/id/ENSBTAT00000031581.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031532.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031532.5" } ] } }, { "isoform_ac": "A0ABI0NIV8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#A0ABI0NIV8-1", "sequence": { "sequence": "MLLRARKTTGSILWRVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 152, "header": "tr|A0ABI0NIV8-1|A0ABI0NIV8_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 V2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=4 SV=1 CANONICAL=Q3SZ43-1" }, "locus": { "chromosome": "14", "start_pos": 19612161, "end_pos": 19605373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136139.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136139.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104223.1" } ] } }, { "isoform_ac": "A0ABI0NNN0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#A0ABI0NNN0-1", "sequence": { "sequence": "MILAFNPSLRVSGCVSGSRKPRGGPAVTHRKPRRGSREPEAAGRAVALPEVARTSRASERCVGLQEKMAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 212, "header": "tr|A0ABI0NNN0-1|A0ABI0NNN0_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 V2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=4 SV=1 CANONICAL=Q3SZ43-1" }, "locus": { "chromosome": "14", "start_pos": 19612161, "end_pos": 19592872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144927.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144927.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107320.1" } ] } }, { "isoform_ac": "A0ABI0NRP9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#A0ABI0NRP9-1", "sequence": { "sequence": "MIPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 138, "header": "tr|A0ABI0NRP9-1|A0ABI0NRP9_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 V2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=4 SV=1 CANONICAL=Q3SZ43-1" }, "locus": { "chromosome": "14", "start_pos": 19612161, "end_pos": 19606244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138091.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138091.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105343.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105343.1" } ] } }, { "isoform_ac": "Q3SZ43-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43/entry#Q3SZ43-1", "sequence": { "sequence": "MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 145, "header": "sp|Q3SZ43-1|UB2V2_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 variant 2 OS=Bos taurus OX=9913 GN=UBE2V2 PE=2 SV=3 CANONICAL=Q3SZ43-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:286803", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286803", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QHC8-1", "protein_name": "Ubiquitin conjugating enzyme E2 V2", "gene_name": "UBE2V2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "FKRDVPFSCLVPVCVLGLAGEEEVLQSQRGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKIECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 169 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15819-1", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "UBE2V2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 145 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5F3Z3-1", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "UBE2V2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGSTVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPTVRFVTKINMNGINNSNGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 144 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6PEH5-1", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "ube2v2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAASSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPARTNYENRIYSLKVECGPKYPEVPPTVRFVTKISMNGINNSNGMVDARSIPILAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYSN", "length": 145 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7M767-1", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "Ube2v2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN", "length": 145 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D2M8-1", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "Ube2v2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTYNN", "length": 145 }, "evidence": [ { "id": "Q3SZ43", "url": "https://omabrowser.org/oma/group/Q3SZ43/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ubiquitin conjugating enzyme complex", "id": "GO:0031371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031371", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ], "pmid": "" }, { "name": "DNA damage tolerance", "id": "GO:0006301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006301", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ43", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ43-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 145, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ43-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ43" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ43" }, { "id": "PRU00388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00388" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 145, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 92, "end_pos": 94 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ59-1", "uniprot_ac": "Q3SZ59", "uniprot_id": "RL36A_BOVIN", "mass": { "chemical_mass": 12441.0, "monoisotopic_mass": 12441.0 }, "refseq": { "ac": "NP_001029488", "name": "large ribosomal subunit protein eL42", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029488" }, "gene_names": [ { "name": "LOC101906221", "type": "recommended", "evidence": [ { "id": "Q3SZ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ] }, { "name": "RPL36A", "type": "recommended", "evidence": [ { "id": "Q3SZ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ] }, { "name": "RPL36A", "type": "synonym", "evidence": [ { "id": "NP_001029488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029488" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL42", "type": "recommended", "evidence": [ { "id": "Q3SZ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L36a", "type": "synonym", "evidence": [ { "id": "NP_001029488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029488" }, { "id": "Q3SZ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL42", "type": "synonym", "evidence": [ { "id": "NP_001029488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029488" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59#function" }, { "database": "UniProtKB", "id": "P83881", "url": "https://www.uniprot.org/uniprotkb/P83881#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL36A", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59", "locus": {} } ], "crossref": [ { "id": "Q3SZ59", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019253", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019253", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508165", "url": "https://www.ncbi.nlm.nih.gov/gene/508165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000552", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000552", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKKHTIH", "url": "https://omabrowser.org/oma/group/CKKHTIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ59", "url": "https://www.orthodb.org/?gene=Q3SZ59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00935", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00935", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z181", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z181-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z181-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ59-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106, "header": "sp|Q3SZ59-1|RL36A_BOVIN Isoform 1 of Large ribosomal subunit protein eL42 OS=Bos taurus OX=9913 GN=RPL36A PE=3 SV=3 CANONICAL=Q3SZ59-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z181-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59/entry#A0AAF6Z181-1", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGG", "length": 95, "header": "tr|A0AAF6Z181-1|A0AAF6Z181_BOVIN Computationally mapped isoform of 60S ribosomal protein L36a-like OS=Bos taurus OX=9913 GN=LOC101906221 PE=3 SV=1 CANONICAL=Q3SZ59-1" }, "locus": {} }, { "isoform_ac": "Q3SZ59-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59/entry#Q3SZ59-1", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106, "header": "sp|Q3SZ59-1|RL36A_BOVIN Isoform 1 of Large ribosomal subunit protein eL42 OS=Bos taurus OX=9913 GN=RPL36A PE=3 SV=3 CANONICAL=Q3SZ59-1" }, "locus": { "chromosome": "10", "start_pos": 42657836, "end_pos": 42657519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145080.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145080.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107296.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107296.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508165", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HLJ9-1", "protein_name": "60S ribosomal protein L36a", "gene_name": "LOC100754891", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O23290-1", "protein_name": "Large ribosomal subunit protein eL42z/eL42y", "gene_name": "RPL36AB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVNIPKTKNTYCKNKECKKHTLHKVTQYKKGKDSLAAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLQCQSCKHFSQRPIKRCKHFEIGGDKKGKGTSLF", "length": 105 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0CX27-1", "protein_name": "Large ribosomal subunit protein eL42A", "gene_name": "RPL42A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX28-1", "protein_name": "Large ribosomal subunit protein eL42B", "gene_name": "RPL42B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P61485-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "rpl36a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVNVPKTRRTYCKKCKKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P83881-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "RPL36A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P83882-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P83883-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" }, { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q969Q0-1", "protein_name": "Ribosomal protein eL42-like", "gene_name": "RPL36AL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGRRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VLT7-1", "protein_name": "Ribosomal protein L36A, isoform B", "gene_name": "RpL36A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVNVPKQRRTFCKKCKVHKLHKVTQYKKSKERKGAQGRRRYDRKQQGFGGQTKPIFRKKAKTTKKIVLRMECTECKYRKQTPLKRCKHFELGGDKKRKGQMIQF", "length": 104 }, "evidence": [ { "id": "Q3SZ59", "url": "https://omabrowser.org/oma/group/Q3SZ59/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ59", "url": "https://www.uniprot.org/uniprotkb/Q3SZ59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ59-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 106, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ59-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ59" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ70-1", "uniprot_ac": "Q3SZ70", "uniprot_id": "CV039_BOVIN", "mass": { "chemical_mass": 11709.0, "monoisotopic_mass": 11709.0 }, "refseq": { "ac": "NP_001035621", "name": "synaptic plasticity regulator PANTS", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621" }, "gene_names": [ { "name": "C17H22orf39", "type": "synonym", "evidence": [ { "id": "NP_001035621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621" } ] } ], "protein_names": [ { "name": "Synaptic plasticity regulator PANTS", "type": "recommended", "evidence": [ { "id": "Q3SZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70/entry#names_and_taxonomy" } ] }, { "name": "Plasticity-associated neural transcript short", "type": "synonym", "evidence": [ { "id": "Q3SZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70/entry#names_and_taxonomy" } ] }, { "name": "UPF0545 protein C22orf39 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621" } ] }, { "name": "plasticity-associated neural transcript", "type": "synonym", "evidence": [ { "id": "NP_001035621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621" } ] }, { "name": "synaptic plasticity regulator PANTS", "type": "synonym", "evidence": [ { "id": "NP_001035621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621" } ] } ], "function": [ { "annotation": "Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70#function" }, { "database": "UniProtKB", "id": "Q3U595", "url": "https://www.uniprot.org/uniprotkb/Q3U595#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70", "locus": {} } ], "crossref": [ { "id": "Q3SZ70", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ70", "database": "AlphaFoldDB", "categories": [] }, { "id": "515651", "url": "https://www.ncbi.nlm.nih.gov/gene/515651", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515651", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515651", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ70", "url": "https://www.orthodb.org/?gene=Q3SZ70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28052:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28052:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035621", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ70-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGEGWRPPRPCEAYRAEWELCRSAGHFLRHYYVHGERPACGQWRRDLASCREWEERRSAEAQADSLPPGPEGEPRVAGAGPNAVTGILTRNQGTERPHGDTR", "length": 104, "header": "sp|Q3SZ70-1|CV039_BOVIN Isoform 1 of Synaptic plasticity regulator PANTS OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3SZ70-1" }, "isoforms": [ { "isoform_ac": "Q3SZ70-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70/entry#Q3SZ70-1", "sequence": { "sequence": "MAEGEGWRPPRPCEAYRAEWELCRSAGHFLRHYYVHGERPACGQWRRDLASCREWEERRSAEAQADSLPPGPEGEPRVAGAGPNAVTGILTRNQGTERPHGDTR", "length": 104, "header": "sp|Q3SZ70-1|CV039_BOVIN Isoform 1 of Synaptic plasticity regulator PANTS OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3SZ70-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515651", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515651", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of long-term synaptic potentiation", "id": "GO:1900272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900272", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ70", "url": "https://www.uniprot.org/uniprotkb/Q3SZ70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ70-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ70-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ70" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ72-1", "uniprot_ac": "Q3SZ72", "uniprot_id": "KCP3_BOVIN", "mass": { "chemical_mass": 25898.0, "monoisotopic_mass": 25898.0 }, "refseq": { "ac": "NP_001030234", "name": "keratinocyte-associated protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030234" }, "gene_names": [ { "name": "KRTCAP3", "type": "recommended", "evidence": [ { "id": "Q3SZ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72" } ] }, { "name": "KRTCAP3", "type": "synonym", "evidence": [ { "id": "NP_001030234", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030234" } ] } ], "protein_names": [ { "name": "Keratinocyte-associated protein 3", "type": "recommended", "evidence": [ { "id": "Q3SZ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72/entry#names_and_taxonomy" } ] }, { "name": "KCP-3", "type": "synonym", "evidence": [ { "id": "NP_001030234", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030234" }, { "id": "Q3SZ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72/entry#names_and_taxonomy" } ] }, { "name": "keratinocyte-associated protein 3", "type": "synonym", "evidence": [ { "id": "NP_001030234", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030234" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ72", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTCAP3", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72", "locus": { "chromosome": "11", "start_pos": 72232726, "end_pos": 72234541, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018156", "url": "https://www.ensembl.org/id/ENSBTAG00000018156" } ] } } ], "crossref": [ { "id": "Q3SZ72", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ72", "database": "AlphaFoldDB", "categories": [] }, { "id": "508550", "url": "https://www.ncbi.nlm.nih.gov/gene/508550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508550", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508550", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ72", "url": "https://www.orthodb.org/?gene=Q3SZ72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030234", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ72", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ72-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCRRLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTTANVISVGSGLLSVSLGLVALLASRNLFRPRLHWALLALALVNLLLSAACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDQGSGHADCPFDPTKIYDTALALWIPSVFMSAAEAALSGYCCVAALTLRGVGPCRKDGLQEQLEELTELEFPKRKWQENVQLLDQTREIRTSQKSWV", "length": 240, "header": "sp|Q3SZ72-1|KCP3_BOVIN Isoform 1 of Keratinocyte-associated protein 3 OS=Bos taurus OX=9913 GN=KRTCAP3 PE=2 SV=1 CANONICAL=Q3SZ72-1" }, "isoforms": [ { "isoform_ac": "Q3SZ72-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72/entry#Q3SZ72-1", "sequence": { "sequence": "MRCRRLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTTANVISVGSGLLSVSLGLVALLASRNLFRPRLHWALLALALVNLLLSAACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDQGSGHADCPFDPTKIYDTALALWIPSVFMSAAEAALSGYCCVAALTLRGVGPCRKDGLQEQLEELTELEFPKRKWQENVQLLDQTREIRTSQKSWV", "length": 240, "header": "sp|Q3SZ72-1|KCP3_BOVIN Isoform 1 of Keratinocyte-associated protein 3 OS=Bos taurus OX=9913 GN=KRTCAP3 PE=2 SV=1 CANONICAL=Q3SZ72-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508550", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508550", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ72", "url": "https://www.uniprot.org/uniprotkb/Q3SZ72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 240, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ72-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ72" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ76-1", "uniprot_ac": "Q3SZ76", "uniprot_id": "COMD3_BOVIN", "mass": { "chemical_mass": 22310.0, "monoisotopic_mass": 22310.0 }, "refseq": { "ac": "NP_001070467", "name": "COMM domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070467" }, "gene_names": [ { "name": "COMMD3", "type": "recommended", "evidence": [ { "id": "Q3SZ76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ] }, { "name": "COMMD3", "type": "synonym", "evidence": [ { "id": "NP_001070467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070467" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q3SZ76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001070467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070467" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76#function" }, { "database": "UniProtKB", "id": "Q9UBI1", "url": "https://www.uniprot.org/uniprotkb/Q9UBI1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD3", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76", "locus": { "chromosome": "13", "start_pos": 23429680, "end_pos": 23425884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003589", "url": "https://www.ensembl.org/id/ENSBTAG00000003589" } ] } } ], "crossref": [ { "id": "Q3SZ76", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ76", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04751", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04751", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767926", "url": "https://www.ncbi.nlm.nih.gov/gene/767926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ76", "url": "https://www.orthodb.org/?gene=Q3SZ76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31159", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31159", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31159:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31159:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21672", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21672", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070467", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ76-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELSEYVQKGFQMLADPGSFDSNTFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHRHAAAATYILEAGKQRADRSTLSTYLEDCKFDSERIELFWTEYQNNRNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLDKMYRPAYLVTLNVENTDSRSHPEISFSCNMEQLQDLVGKLKDASKSLERATQL", "length": 195, "header": "sp|Q3SZ76-1|COMD3_BOVIN Isoform 1 of COMM domain-containing protein 3 OS=Bos taurus OX=9913 GN=COMMD3 PE=2 SV=1 CANONICAL=Q3SZ76-1" }, "isoforms": [ { "isoform_ac": "Q3SZ76-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76/entry#Q3SZ76-1", "sequence": { "sequence": "MELSEYVQKGFQMLADPGSFDSNTFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHRHAAAATYILEAGKQRADRSTLSTYLEDCKFDSERIELFWTEYQNNRNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLDKMYRPAYLVTLNVENTDSRSHPEISFSCNMEQLQDLVGKLKDASKSLERATQL", "length": 195, "header": "sp|Q3SZ76-1|COMD3_BOVIN Isoform 1 of COMM domain-containing protein 3 OS=Bos taurus OX=9913 GN=COMMD3 PE=2 SV=1 CANONICAL=Q3SZ76-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767926", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ], "pmid": "" }, { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ76", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ76-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 195, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ76" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ76" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 193, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ84-1", "uniprot_ac": "Q3SZ84", "uniprot_id": "BOLA3_BOVIN", "mass": { "chemical_mass": 12472.0, "monoisotopic_mass": 12472.0 }, "refseq": { "ac": "NP_001030529", "name": "bolA-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529" }, "gene_names": [ { "name": "BOLA3", "type": "recommended", "evidence": [ { "id": "Q3SZ84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84" } ] }, { "name": "BOLA3", "type": "synonym", "evidence": [ { "id": "NP_001030529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529" } ] } ], "protein_names": [ { "name": "BolA-like protein 3", "type": "recommended", "evidence": [ { "id": "Q3SZ84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84/entry#names_and_taxonomy" } ] }, { "name": "bolA homolog 3", "type": "synonym", "evidence": [ { "id": "NP_001030529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529" } ] }, { "name": "bolA-like 3", "type": "synonym", "evidence": [ { "id": "NP_001030529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529" } ] }, { "name": "bolA-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001030529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529" } ] } ], "function": [ { "annotation": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84#function" }, { "database": "UniProtKB", "id": "Q53S33", "url": "https://www.uniprot.org/uniprotkb/Q53S33#function" }, { "database": "UniProtKB", "id": "P39724", "url": "https://www.uniprot.org/uniprotkb/P39724#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOLA3", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84", "locus": { "chromosome": "11", "start_pos": 10513150, "end_pos": 10505021, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050675", "url": "https://www.ensembl.org/id/ENSBTAG00000050675" } ] } } ], "crossref": [ { "id": "Q3SZ84", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ84", "database": "AlphaFoldDB", "categories": [] }, { "id": "614629", "url": "https://www.ncbi.nlm.nih.gov/gene/614629", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614629", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614629", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ84", "url": "https://www.orthodb.org/?gene=Q3SZ84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46188:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46188:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01722", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01722", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ84-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAWSPAAAVPLLRGTRRLPLLHWAQRMFASQTEAELKVTQILKEKFPRATAIKVTDISGGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIKGMHGLRIFTSVPKH", "length": 110, "header": "sp|Q3SZ84-1|BOLA3_BOVIN Isoform 1 of BolA-like protein 3 OS=Bos taurus OX=9913 GN=BOLA3 PE=3 SV=1 CANONICAL=Q3SZ84-1" }, "isoforms": [ { "isoform_ac": "Q3SZ84-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84/entry#Q3SZ84-1", "sequence": { "sequence": "MAAWSPAAAVPLLRGTRRLPLLHWAQRMFASQTEAELKVTQILKEKFPRATAIKVTDISGGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIKGMHGLRIFTSVPKH", "length": 110, "header": "sp|Q3SZ84-1|BOLA3_BOVIN Isoform 1 of BolA-like protein 3 OS=Bos taurus OX=9913 GN=BOLA3 PE=3 SV=1 CANONICAL=Q3SZ84-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614629", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614629", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ84", "url": "https://www.uniprot.org/uniprotkb/Q3SZ84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ84-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 110, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ84-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ84" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ85-1", "uniprot_ac": "Q3SZ85", "uniprot_id": "PTRD1_BOVIN", "mass": { "chemical_mass": 15973.0, "monoisotopic_mass": 15973.0 }, "refseq": { "ac": "NP_001030568", "name": "putative peptidyl-tRNA hydrolase PTRHD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568" }, "gene_names": [ { "name": "PTRHD1", "type": "recommended", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] }, { "name": "C11H2orf79", "type": "synonym", "evidence": [ { "id": "NP_001030568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568" } ] }, { "name": "PTRHD1", "type": "synonym", "evidence": [ { "id": "NP_001030568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568" } ] } ], "protein_names": [ { "name": "Putative peptidyl-tRNA hydrolase PTRHD1", "type": "recommended", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.29", "type": "synonym", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85/entry#names_and_taxonomy" } ] }, { "name": "Peptidyl-tRNA hydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85/entry#names_and_taxonomy" } ] }, { "name": "peptidyl-tRNA hydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568" } ] }, { "name": "putative peptidyl-tRNA hydrolase PTRHD1", "type": "synonym", "evidence": [ { "id": "NP_001030568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568" } ] } ], "function": [ { "annotation": "As a putative peptidyl-tRNA hydrolase, it might be involved in releasing tRNAs from the ribosome during protein synthesis. Some evidence, however, suggests that it lacks peptidyl-tRNA hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ85", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85#function" }, { "database": "UniProtKB", "id": "Q6GMV3", "url": "https://www.uniprot.org/uniprotkb/Q6GMV3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ85", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTRHD1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85", "locus": { "chromosome": "11", "start_pos": 74443093, "end_pos": 74433206, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065673", "url": "https://www.ensembl.org/id/ENSBTAG00000065673" } ] } } ], "crossref": [ { "id": "Q3SZ85", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015012", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015012", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617088", "url": "https://www.ncbi.nlm.nih.gov/gene/617088", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617088", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617088", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AIIAQCC", "url": "https://omabrowser.org/oma/group/AIIAQCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ85", "url": "https://www.orthodb.org/?gene=Q3SZ85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46194:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46194:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01981", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01981", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030568", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54448", "url": "https://www.rhea-db.org/rhea/54448", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9U072", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U072", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U072-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U072-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ85", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ85-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHRGVGPAFQLSRKMAASGGEPQILVQYLVLRKDLTQPPFSWPAGAVVAQACHAATAALHLHRDHPHTAAYLRELERMRKVVLEAPDETTLKLLAETLQQKNIDHKLWMEQPENIPTCIALRPYPKEEVSQYLKKFRLFK", "length": 140, "header": "sp|Q3SZ85-1|PTRD1_BOVIN Isoform 1 of Putative peptidyl-tRNA hydrolase PTRHD1 OS=Bos taurus OX=9913 GN=PTRHD1 PE=2 SV=2 CANONICAL=Q3SZ85-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U072-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85/entry#A0AAA9U072-1", "sequence": { "sequence": "MHRGVGPAFQLSRKMAASGGEPQILVQYLVLRKDLTQPPFSWPAGAVVAQACHAATAALHLHRDHPHTAAYLRELERMRKVVLEAPDETTLKLLAETLQQKNIDHKLWMEQPENIPTCIALRPYPKEETPPLQKWKY", "length": 137, "header": "tr|A0AAA9U072-1|A0AAA9U072_BOVIN Computationally mapped isoform of peptidyl-tRNA hydrolase OS=Bos taurus OX=9913 GN=PTRHD1 PE=4 SV=1 CANONICAL=Q3SZ85-1" }, "locus": { "chromosome": "11", "start_pos": 74442603, "end_pos": 74433218, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110630.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110630.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102978.1" } ] } }, { "isoform_ac": "Q3SZ85-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85/entry#Q3SZ85-1", "sequence": { "sequence": "MHRGVGPAFQLSRKMAASGGEPQILVQYLVLRKDLTQPPFSWPAGAVVAQACHAATAALHLHRDHPHTAAYLRELERMRKVVLEAPDETTLKLLAETLQQKNIDHKLWMEQPENIPTCIALRPYPKEEVSQYLKKFRLFK", "length": 140, "header": "sp|Q3SZ85-1|PTRD1_BOVIN Isoform 1 of Putative peptidyl-tRNA hydrolase PTRHD1 OS=Bos taurus OX=9913 GN=PTRHD1 PE=2 SV=2 CANONICAL=Q3SZ85-1" }, "locus": { "chromosome": "11", "start_pos": 74436677, "end_pos": 74433218, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107102.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:617088", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617088", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1P8BD66-1", "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "MAJ23.60", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATAVLSAAFRFPIVTRRLSAPAPRIRFYHSTIRFAHFRRFTTASPSMSQQTGEIDAVVDASSAEKPDDVVVQYVVLRRDLIDSWPLGSVVTQGCHASVAAIWSFKDDPVTLQYCDPQHIDSMHKVTLEVKGETQMMNLSEKLKLGGISHKLWMEQPENIPTCIATKPYPKSQVSSFFKKLKLCK", "length": 185 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A8V0Y6G8-1", "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "PTRHD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRGHASPYSNMAAPGTAAGAATATALVQYVVLRGDLARSWSLGAVVAQGCHAALAAAHAHWHHPDTRAYLSAGGAMRTVVLEAPDEAALTALAQTLQQHSIDHEVWTEQPENVPSCLALRPYPKDQVHPHLKKFKLLK", "length": 138 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3Z4S3-1", "protein_name": "Putative peptidyl-tRNA hydrolase PTRHD1", "gene_name": "Ptrhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHRKVRPASLMIRKMACSGVEPQILVQYLVLRKDLSQAPFSWPTGALVAQACHAATAALHLHRDHPHTAAYLRELGRMRKVVLEAADETTLKELAETLQQKNIDHTLWLEQPENIATCIALRPYPKEEVSQYLKKFRLFK", "length": 140 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZBG6-1", "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "Ptrhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRKMRPAILMIRKMAGSGVEPQILVQYLVLRKDLSQAPFSWPTGALVAQACHAATAALHLHRDHPHTAAYLRELGRMRKVVLEAADETTLKELAETLQQKNVDHTLWLEQPENIATCIALRPYPKEEVSQYLKKFRLFK", "length": 140 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5RIN6-1", "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "ptrhd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATPGSGSSRRLVQYVIVRSDLIHSLSWPLGAVITQACHAATAAIHLHYSDPDTQQYLAELDSMHKVVLQAPDEASLSTLSSTLEEKDIAHKLWMEQPENIPTCLALKPYPKETVQPYLKKFKLFK", "length": 126 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6GMV3-1", "protein_name": "Putative peptidyl-tRNA hydrolase PTRHD1", "gene_name": "PTRHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHRGVGPAFRVVRKMAASGAEPQVLVQYLVLRKDLSQAPFSWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNIDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLFK", "length": 140 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VET3-1", "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "Dmel\\CG14903", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNIVQYIVVRSDLRSALSWPLGAVIAQSCHATAAVIHLNSEDADTVAYLNDLDNMHKVVLEAKDESALVKLSEKLKENEIKHKLWIEQPENIPTCIALKPYVKDTVHKYVKHLKLLKE", "length": 119 }, "evidence": [ { "id": "Q3SZ85", "url": "https://omabrowser.org/oma/group/Q3SZ85/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-tRNA hydrolase activity", "id": "GO:0004045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004045", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ85", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54448", "name": "", "equation": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZ85-1", "Q3ZBL5-1", "Q3T116-1", "A0AAA9SGN5-1" ], "evidence": [ { "id": "54448", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54448" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SGN5", "gene_name": "PTRH1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] } ] }, { "uniprot_ac": "Q3SZ85", "gene_name": "PTRHD1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] } ] }, { "uniprot_ac": "Q3T116", "gene_name": "MRPL58", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] } ] }, { "uniprot_ac": "Q3ZBL5", "gene_name": "PTRH2", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ85-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ85-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ85" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.29", "ec_name": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "3.1.1.29", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29" }, { "id": "3.1.1.29", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.29" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ87-1", "uniprot_ac": "Q3SZ87", "uniprot_id": "SSRG_BOVIN", "mass": { "chemical_mass": 21075.0, "monoisotopic_mass": 21075.0 }, "refseq": { "ac": "NP_001070512", "name": "translocon-associated protein subunit gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" }, "gene_names": [ { "name": "SSR3", "type": "recommended", "evidence": [ { "id": "Q3SZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ] }, { "name": "SSR3", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" } ] } ], "protein_names": [ { "name": "Translocon-associated protein subunit gamma", "type": "recommended", "evidence": [ { "id": "Q3SZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#names_and_taxonomy" } ] }, { "name": "SSR-gamma", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" }, { "id": "Q3SZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#names_and_taxonomy" } ] }, { "name": "Signal sequence receptor subunit gamma", "type": "synonym", "evidence": [ { "id": "Q3SZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#names_and_taxonomy" } ] }, { "name": "TRAP-gamma", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" }, { "id": "Q3SZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#names_and_taxonomy" } ] }, { "name": "signal sequence receptor subunit gamma", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" } ] }, { "name": "signal sequence receptor, gamma (translocon-associated protein gamma)", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" } ] }, { "name": "translocon-associated protein subunit gamma", "type": "synonym", "evidence": [ { "id": "NP_001070512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512" } ] } ], "function": [ { "annotation": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87#function" }, { "database": "UniProtKB", "id": "A0ABI0NJA2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA2#function" }, { "database": "UniProtKB", "id": "ARBA00002838", "url": "https://www.uniprot.org/uniprotkb/ARBA00002838#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87", "locus": { "chromosome": "1", "start_pos": 111107054, "end_pos": 111095801, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018471", "url": "https://www.ensembl.org/id/ENSBTAG00000018471" } ] } } ], "crossref": [ { "id": "Q3SZ87", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767980", "url": "https://www.ncbi.nlm.nih.gov/gene/767980", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767980", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767980", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PLWLFWR", "url": "https://omabrowser.org/oma/group/PLWLFWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ87", "url": "https://www.orthodb.org/?gene=Q3SZ87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13399:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13399:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07074", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07074", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070512", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ87-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKGGPKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 185, "header": "sp|Q3SZ87-1|SSRG_BOVIN Isoform 1 of Translocon-associated protein subunit gamma OS=Bos taurus OX=9913 GN=SSR3 PE=2 SV=1 CANONICAL=Q3SZ87-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NJA2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#A0ABI0NJA2-1", "sequence": { "sequence": "MAPKGGPKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERFDSYLKCGNQKGGILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 198, "header": "tr|A0ABI0NJA2-1|A0ABI0NJA2_BOVIN Computationally mapped isoform of Translocon-associated protein subunit gamma OS=Bos taurus OX=9913 GN=SSR3 PE=1 SV=1 CANONICAL=Q3SZ87-1" }, "locus": { "chromosome": "1", "start_pos": 111106821, "end_pos": 111095846, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140019.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140019.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104464.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104464.1" } ] } }, { "isoform_ac": "Q3SZ87-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87/entry#Q3SZ87-1", "sequence": { "sequence": "MAPKGGPKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 185, "header": "sp|Q3SZ87-1|SSRG_BOVIN Isoform 1 of Translocon-associated protein subunit gamma OS=Bos taurus OX=9913 GN=SSR3 PE=2 SV=1 CANONICAL=Q3SZ87-1" }, "locus": { "chromosome": "1", "start_pos": 111106821, "end_pos": 111095846, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154702.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154702.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105867.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105867.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "site_lbl": "Ser105" }, { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "site_lbl": "Ser11" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767980", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767980", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LGD6-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "SSR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPKGGSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 185 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q55GT5-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "ssr3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAEVDEFSAFRHENDVSIEQRIVYFINSLIVALVPVYLYHAIFFMSIDDHMIIYGSVTLFAAIVLTFAYNNIYRMKRLKLSASREHISIASKNKVGDKKKFAAAQKEVQALVTSHEAIAASIMYNNAVFLICVSIFSFIIFKNVPLVYNYIISISLGAGLTSFLSTSSKH", "length": 170 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DCF9-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "Ssr3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPKGGSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 185 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UNL2-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "SSR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK", "length": 185 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VL69-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "CK01296", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGSGKQQKVQSSGFTKEEELLLQDFSRNVSTKSSALFYGNAFIVSAVPIWLFWRIHNMDLWPSSILFVLVTAASTYLMATAYKNIKFQLKHKIAGRREEAVTREVNRQVGDDKKVTRKEKDERILWKKNEVADYEATTFSIFYNNAIYLAVIIFISFFILKNSTPFINYIFSVGIASGALSLFSTSAQTN", "length": 190 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "R4GJK4-1", "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "SSR3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPKGGPGGRQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLVQSAVLYSVMTLISTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIIASFFVLKNFNPTVNYILSISASSGLIALLSTGSK", "length": 187 }, "evidence": [ { "id": "Q3SZ87", "url": "https://omabrowser.org/oma/group/Q3SZ87/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ87", "url": "https://www.uniprot.org/uniprotkb/Q3SZ87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ87-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ87-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ87" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11, 105 ], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 23, "end_pos": 25 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ89-1", "uniprot_ac": "Q3SZ89", "uniprot_id": "TECRL_BOVIN", "mass": { "chemical_mass": 42058.0, "monoisotopic_mass": 42058.0 }, "refseq": { "ac": "NP_001073793", "name": "trans-2,3-enoyl-CoA reductase-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" }, "gene_names": [ { "name": "TECRL", "type": "recommended", "evidence": [ { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ] }, { "name": "SRD5A2L2", "type": "synonym", "evidence": [ { "id": "NP_001073793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" }, { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ] }, { "name": "TECRL", "type": "synonym", "evidence": [ { "id": "NP_001073793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" } ] } ], "protein_names": [ { "name": "Trans-2,3-enoyl-CoA reductase-like", "type": "recommended", "evidence": [ { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89/entry#names_and_taxonomy" } ] }, { "name": "1.3.1.-", "type": "synonym", "evidence": [ { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89/entry#names_and_taxonomy" } ] }, { "name": "Steroid 5-alpha-reductase 2-like 2 protein", "type": "synonym", "evidence": [ { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89/entry#names_and_taxonomy" } ] }, { "name": "steroid 5 alpha-reductase 2-like 2", "type": "synonym", "evidence": [ { "id": "NP_001073793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" } ] }, { "name": "steroid 5-alpha-reductase 2-like 2 protein", "type": "synonym", "evidence": [ { "id": "NP_001073793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" } ] }, { "name": "trans-2,3-enoyl-CoA reductase-like", "type": "synonym", "evidence": [ { "id": "NP_001073793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TECRL", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89", "locus": { "chromosome": "6", "start_pos": 79787721, "end_pos": 79930156, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024826", "url": "https://www.ensembl.org/id/ENSBTAG00000024826" } ] } } ], "crossref": [ { "id": "Q3SZ89", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024826", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024826", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17125", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17125", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616643", "url": "https://www.ncbi.nlm.nih.gov/gene/616643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQVSWTT", "url": "https://omabrowser.org/oma/group/RQVSWTT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ89", "url": "https://www.orthodb.org/?gene=Q3SZ89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21696", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21696", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75876", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001073793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073793", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ89-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFKRHKSLASERRRELISRGATRSILKDDMKNFHFLSQFILSAGPLKSTSAVKHSKTIHFEIEILDAQTKKQICIVDKVTQKSTIHDVKQKFHKACPQWYPSRVGLQLERGGPFLKDNLTIQSVAASSIVTLYFTDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPYIYNMKESSRRLCHPVVHLACFCHCIHYIRYLLETLFVHKVSSGHTSLKNLLKSCAFYWGFTSWIAYYINHPRYTPPSFGYRQVAISAINFLICEAGNHFINVVLSHPSHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTIMTQTLPVGIFTLLMSIQMSLWAKKKHKIYLKKFSSYMHRKSAMIPFIL", "length": 363, "header": "sp|Q3SZ89-1|TECRL_BOVIN Isoform 1 of Trans-2,3-enoyl-CoA reductase-like OS=Bos taurus OX=9913 GN=TECRL PE=2 SV=1 CANONICAL=Q3SZ89-1" }, "isoforms": [ { "isoform_ac": "Q3SZ89-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89/entry#Q3SZ89-1", "sequence": { "sequence": "MFKRHKSLASERRRELISRGATRSILKDDMKNFHFLSQFILSAGPLKSTSAVKHSKTIHFEIEILDAQTKKQICIVDKVTQKSTIHDVKQKFHKACPQWYPSRVGLQLERGGPFLKDNLTIQSVAASSIVTLYFTDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPYIYNMKESSRRLCHPVVHLACFCHCIHYIRYLLETLFVHKVSSGHTSLKNLLKSCAFYWGFTSWIAYYINHPRYTPPSFGYRQVAISAINFLICEAGNHFINVVLSHPSHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTIMTQTLPVGIFTLLMSIQMSLWAKKKHKIYLKKFSSYMHRKSAMIPFIL", "length": 363, "header": "sp|Q3SZ89-1|TECRL_BOVIN Isoform 1 of Trans-2,3-enoyl-CoA reductase-like OS=Bos taurus OX=9913 GN=TECRL PE=2 SV=1 CANONICAL=Q3SZ89-1" }, "locus": { "chromosome": "6", "start_pos": 79930109, "end_pos": 79788215, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034572.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034572.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034462.2", "url": "https://www.ensembl.org/id/ENSBTAP00000034462.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "site_lbl": "Ser37" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616643", "resource": "KEGG Pathway" }, { "id": "R-BTA-75876", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P442-1", "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "TECRL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRRRKTSASELKRDLSAHGGALSMSQNTRTFFNFSQLVLSAGHLKPPPVLKHSKVTYFEVEILDVQSKKQICIVDKIPPSSTLLDVKHKFHKACPQWYPSRVGLQLERNGPYLKDSVNIQSLAASSIITLYFTDLGQQVGWTTFFLTEYTGPLLIYLLFYIRLSTIYDQVESTKNFRHPVVHLACFCHCLHYIRHLLETLFVHKFSGGHTPLKNMIKGCVFYWGFTSWIAYYINHPRYTPPSFGHRQVSLAALAFLMCEAGNHFINVALAHQNHSGNKACFPSPTYNPFTWLFLLVSCPNYTYEVGSWISFTVMTQTLPVGIFAFLMVIQMSLWAQKKHKLYLKKFYPEVRRKAAMIPIVF", "length": 362 }, "evidence": [ { "id": "Q3SZ89", "url": "https://omabrowser.org/oma/group/Q3SZ89/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287ADJ1-1", "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "TECRL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFKRHRSLASERKRELISPGATRSMLKNDMRNFHSLSQFILSAGPLKSIPAVKHAKTIHFEIEILDAQTRKQICIVDKVTQKSTIQDVKQKFHKACPKWYPSRVGLQLERGGPFLKDYRTIQSIAVSSIITLYFTDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPYIYDIKESSRRLRHPVVHLACFCHCIHYLRYLLETLFVHKVSAGHTPLKNLIKSCAFYWGFTSWIAYYINHPRYTPPSFGNKQITVSAINFLICEAGNHFINVMLAHPNHTGSNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTLLISIQMSLWAQKKHKNYLKKFNSYIHKKSAMIPFIL", "length": 363 }, "evidence": [ { "id": "Q3SZ89", "url": "https://omabrowser.org/oma/group/Q3SZ89/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A1Y9-1", "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "Tecrl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFKRHKSLERKRELLFQGLPQFTMKNNTRNFHSLSQLVLSAGPLKTTTAVKHSKTTHFEIEILDAHTRKQICIVDKVTQTSTIYDVKQKFHKACPKWYPSRIGLQLEYGGPYLKDYITIQSVAASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESFRWPRHTVVHLACFCHCIHYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQIIVSAINFLMCEAGNHFINTVLAHPSHTGSNACFPSPTYNPFTWMFFLVSCPNYTYEIGTWISFTIMTQTLPVGIFTMLMTIQMSLWARKKHKIYRKKFNSYVHRKSAIIPFIL", "length": 361 }, "evidence": [ { "id": "Q3SZ89", "url": "https://omabrowser.org/oma/group/Q3SZ89/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5HYJ1-1", "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "TECRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFKRHKSLASERKRALLSQRATRFILKDDMRNFHFLSKLVLSAGPLRPTPAVKHSKTTHFEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPCIYDGKESARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWGFTSWIAYYINHPLYTPPSFGNRQITVSAINFLICEAGNHFINVMLSHPNHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTLLMSIQMSLWAQKKHKIYLRKFNSYIHRKSAMIPFIL", "length": 363 }, "evidence": [ { "id": "Q3SZ89", "url": "https://omabrowser.org/oma/group/Q3SZ89/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BFZ1-1", "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "Tecrl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFKRHKSLERKRELLFQGLPQSTMKNNARNFHSLSQLVLSAGPLKTTTAVKHSKTTHFEIEILDAHTRKQICIVDKVTQTSTIHDVKQKFHKACPKWYPSRIGLQLEYGGPYLRDYITVQSVAASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESTRWPRHPVVHLAFFCHCIHYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQVIVSAINFLFCEAGNHFINTVLAHPNHTGSNACFPSPNYNPFTWLFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTILMTIQMSLWARKKHKIYRKKFNSYVHRKSAIIPLIL", "length": 361 }, "evidence": [ { "id": "Q3SZ89", "url": "https://omabrowser.org/oma/group/Q3SZ89/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sphingolipid metabolic process", "id": "GO:0006665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006665", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "pmid": "" }, { "name": "very long-chain fatty acid biosynthetic process", "id": "GO:0042761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042761", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "very-long-chain enoyl-CoA reductase activity", "id": "GO:0102758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102758", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ89", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-548809" ], "output_participant_list": [], "enzyme_list": [ "Q3ZCD7-1", "Q3SZ89-1" ], "evidence": [ { "id": "R-BTA-548831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-548831" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-548809", "participant_name": "TOD-CoA [cytosol]", "crossref": [ { "id": "71412", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q3SZ89", "gene_name": "TECRL", "activity": [ { "ec_number": "1.3.1.-", "activity": "", "evidence": [ { "id": "Q3SZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ89" } ] } ] }, { "uniprot_ac": "Q3ZCD7", "gene_name": "TECR", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+).", "evidence": [ { "id": "Q3ZCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD7" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q3ZCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ89-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 363, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ89-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ89" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 37 ], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 302, "end_pos": 304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ93-1", "uniprot_ac": "Q3SZ93", "uniprot_id": "TIM8B_BOVIN", "mass": { "chemical_mass": 9372.0, "monoisotopic_mass": 9372.0 }, "refseq": { "ac": "NP_001032718", "name": "mitochondrial import inner membrane translocase subunit Tim8 B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032718" }, "gene_names": [ { "name": "TIMM8B", "type": "recommended", "evidence": [ { "id": "Q3SZ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93" } ] }, { "name": "TIMM8B", "type": "synonym", "evidence": [ { "id": "NP_001032718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032718" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "type": "recommended", "evidence": [ { "id": "Q3SZ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim8 B", "type": "synonym", "evidence": [ { "id": "NP_001032718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032718" } ] } ], "function": [ { "annotation": "Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM8B", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93", "locus": { "chromosome": "15", "start_pos": 22395340, "end_pos": 22397344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002000", "url": "https://www.ensembl.org/id/ENSBTAG00000002000" } ] } } ], "crossref": [ { "id": "Q3SZ93", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002000", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002000", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618131", "url": "https://www.ncbi.nlm.nih.gov/gene/618131", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618131", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618131", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEICWDK", "url": "https://omabrowser.org/oma/group/NEICWDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ93", "url": "https://www.orthodb.org/?gene=Q3SZ93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF02953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032718", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ93-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQRGGQ", "length": 83, "header": "sp|Q3SZ93-1|TIM8B_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim8 B OS=Bos taurus OX=9913 GN=TIMM8B PE=3 SV=1 CANONICAL=Q3SZ93-1" }, "isoforms": [ { "isoform_ac": "Q3SZ93-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93/entry#Q3SZ93-1", "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQRGGQ", "length": 83, "header": "sp|Q3SZ93-1|TIM8B_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim8 B OS=Bos taurus OX=9913 GN=TIMM8B PE=3 SV=1 CANONICAL=Q3SZ93-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618131", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618131", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F2Z5V7-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM8B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNRKSGVGTRPLHRRTQIRRKVARLTRKMAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQKGGQ", "length": 111 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H2H8-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "Timm8b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ", "length": 83 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P57744-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM8", "gene_name": "TIM8", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSLSTSDLASLDDTSKKEIATFLEGENSKQKVQMSIHQFTNICFKKCVESVNDSNLSSQEEQCLSNCVNRFLDTNIRIVNGLQNTR", "length": 87 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P62077-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "gene_name": "Timm8b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGSRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ", "length": 83 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62078-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "gene_name": "Timm8b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGSRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ", "length": 83 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9XGY4-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM8", "gene_name": "TIM8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDPSMANNPELLQFLAQEKERAMVNEMVSKMTSVCWDKCITSAPGSKFSSSESSCLTHCAQRYMDMSMIIMKRFNSQ", "length": 77 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9Y1A3-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8", "gene_name": "Tim8", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDFENLSGNDKELQEFLLIEKQKAQVNAQIHEFNEICWEKCIGKPSTKLDHATETCLSNCVDRFIDTSLLITQRFAQMLQKRGGGDL", "length": 88 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y5J9-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "gene_name": "TIMM8B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQKGGQ", "length": 83 }, "evidence": [ { "id": "Q3SZ93", "url": "https://omabrowser.org/oma/group/Q3SZ93/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ93", "url": "https://www.uniprot.org/uniprotkb/Q3SZ93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ93-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 83, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ93-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ93" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ97-1", "uniprot_ac": "Q3SZ97", "uniprot_id": "SMIM7_BOVIN", "mass": { "chemical_mass": 8617.0, "monoisotopic_mass": 8617.0 }, "refseq": { "ac": "NP_001192305", "name": "small integral membrane protein 7 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305" }, "gene_names": [ { "name": "SMIM7", "type": "recommended", "evidence": [ { "id": "Q3SZ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97" } ] }, { "name": "C7H19orf42", "type": "synonym", "evidence": [ { "id": "NP_001192305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305" } ] }, { "name": "SMIM7", "type": "synonym", "evidence": [ { "id": "NP_001192305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 7", "type": "recommended", "evidence": [ { "id": "Q3SZ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97/entry#names_and_taxonomy" } ] }, { "name": "UPF0608 protein C19orf42 homolog", "type": "synonym", "evidence": [ { "id": "NP_001192305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305" } ] }, { "name": "small integral membrane protein 7 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ97", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM7", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97", "locus": { "chromosome": "7", "start_pos": 6395767, "end_pos": 6384274, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013613", "url": "https://www.ensembl.org/id/ENSBTAG00000013613" } ] } } ], "crossref": [ { "id": "Q3SZ97", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013613", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013613", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613429", "url": "https://www.ncbi.nlm.nih.gov/gene/613429", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613429", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613429", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LWNILVM", "url": "https://omabrowser.org/oma/group/LWNILVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ97", "url": "https://www.orthodb.org/?gene=Q3SZ97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28622", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28622", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28622:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28622:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192305", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIX5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ97", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ97-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNIREFLLSLRYFRIFIALWNVFMMFCMIVLFGS", "length": 75, "header": "sp|Q3SZ97-1|SMIM7_BOVIN Isoform 1 of Small integral membrane protein 7 OS=Bos taurus OX=9913 GN=SMIM7 PE=3 SV=1 CANONICAL=Q3SZ97-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0P1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97/entry#A0AAA9T0P1-1", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGCLVPELQMQNREHTF", "length": 56, "header": "tr|A0AAA9T0P1-1|A0AAA9T0P1_BOVIN Computationally mapped isoform of Small integral membrane protein 7 OS=Bos taurus OX=9913 GN=SMIM7 PE=3 SV=1 CANONICAL=Q3SZ97-1" }, "locus": { "chromosome": "7", "start_pos": 6395681, "end_pos": 6384318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125340.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125340.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092348.1" } ] } }, { "isoform_ac": "A0AAF6ZIX5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97/entry#A0AAF6ZIX5-1", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNIREFLLSLRYFRIFIALWNVFMMFCMIVKISSWIGFPVSVRAIIPILLLMNYETQGK", "length": 100, "header": "tr|A0AAF6ZIX5-1|A0AAF6ZIX5_BOVIN Computationally mapped isoform of Small integral membrane protein 7 OS=Bos taurus OX=9913 GN=SMIM7 PE=3 SV=1 CANONICAL=Q3SZ97-1" }, "locus": { "chromosome": "7", "start_pos": 6389824, "end_pos": 6384318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054391.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054391.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049146.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049146.4" } ] } }, { "isoform_ac": "Q3SZ97-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97/entry#Q3SZ97-1", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNIREFLLSLRYFRIFIALWNVFMMFCMIVLFGS", "length": 75, "header": "sp|Q3SZ97-1|SMIM7_BOVIN Isoform 1 of Small integral membrane protein 7 OS=Bos taurus OX=9913 GN=SMIM7 PE=3 SV=1 CANONICAL=Q3SZ97-1" }, "locus": { "chromosome": "7", "start_pos": 6395647, "end_pos": 6384318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142310.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142310.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106939.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613429", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613429", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QQ31-1", "protein_name": "Small integral membrane protein 7", "gene_name": "SMIM7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNIREFLLSLRYFRIFIALWNVFMMFCMIVLFGS", "length": 75 }, "evidence": [ { "id": "Q3SZ97", "url": "https://omabrowser.org/oma/group/Q3SZ97/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7HBG1-1", "protein_name": "Small integral membrane protein 7 isoform X1", "gene_name": "Smim7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLRQHPGVPTEPEVLPDLHRPVECVHDAVHDCSVWLLRTQSSPAGCRGSVSVLMTSRMFHRKTRDFPRGLELIWMEIVHFPAT", "length": 104 }, "evidence": [ { "id": "Q3SZ97", "url": "https://omabrowser.org/oma/group/Q3SZ97/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5RKS2-1", "protein_name": "Small integral membrane protein 7", "gene_name": "Smim7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESKEPSTGDNIREFLLSLRYFRIFIALWNVFMMLCMIVLFGS", "length": 75 }, "evidence": [ { "id": "Q3SZ97", "url": "https://omabrowser.org/oma/group/Q3SZ97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQ49-1", "protein_name": "Small integral membrane protein 7", "gene_name": "SMIM7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNIREFLLSLRYFRIFIALWNIFMMFCMIVLFGS", "length": 75 }, "evidence": [ { "id": "Q3SZ97", "url": "https://omabrowser.org/oma/group/Q3SZ97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ97", "url": "https://www.uniprot.org/uniprotkb/Q3SZ97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 75, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ97" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZA2-1", "uniprot_ac": "Q3SZA2", "uniprot_id": "FMC1_BOVIN", "mass": { "chemical_mass": 12852.0, "monoisotopic_mass": 12852.0 }, "refseq": { "ac": "NP_001070465", "name": "protein FMC1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" }, "gene_names": [ { "name": "FMC1", "type": "recommended", "evidence": [ { "id": "Q3SZA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2" } ] }, { "name": "C4H7orf55", "type": "synonym", "evidence": [ { "id": "NP_001070465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" } ] }, { "name": "FMC1", "type": "synonym", "evidence": [ { "id": "NP_001070465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" } ] } ], "protein_names": [ { "name": "Protein FMC1 homolog", "type": "recommended", "evidence": [ { "id": "Q3SZA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2/entry#names_and_taxonomy" } ] }, { "name": "UPF0562 protein C7orf55 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" } ] }, { "name": "formation of mitochondrial complexes 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" } ] }, { "name": "protein FMC1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465" } ] } ], "function": [ { "annotation": "Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2#function" }, { "database": "UniProtKB", "id": "Q96HJ9", "url": "https://www.uniprot.org/uniprotkb/Q96HJ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FMC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2", "locus": {} } ], "crossref": [ { "id": "Q3SZA2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053406", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20271", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20271", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767923", "url": "https://www.ncbi.nlm.nih.gov/gene/767923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037667", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037667", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767923", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHASLTY", "url": "https://omabrowser.org/oma/group/HHASLTY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZA2", "url": "https://www.orthodb.org/?gene=Q3SZA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31716:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31716:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13233", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13233", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070465", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALGSPLRTWRGLLRELRYLNAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIREHVALHQEFHGKGERSVEESAGLVGLKLPQQPGGKGWEP", "length": 113, "header": "sp|Q3SZA2-1|FMC1_BOVIN Isoform 1 of Protein FMC1 homolog OS=Bos taurus OX=9913 GN=FMC1 PE=3 SV=1 CANONICAL=Q3SZA2-1" }, "isoforms": [ { "isoform_ac": "Q3SZA2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2/entry#Q3SZA2-1", "sequence": { "sequence": "MAALGSPLRTWRGLLRELRYLNAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIREHVALHQEFHGKGERSVEESAGLVGLKLPQQPGGKGWEP", "length": 113, "header": "sp|Q3SZA2-1|FMC1_BOVIN Isoform 1 of Protein FMC1 homolog OS=Bos taurus OX=9913 GN=FMC1 PE=3 SV=1 CANONICAL=Q3SZA2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767923", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767923", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1V8F5-1", "protein_name": "Protein FMC1 homolog", "gene_name": "FMC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALGSPVRTWRGLLRELRYLNAATGRHYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIREHVALHQEFHGKGERSVEESAGLVGLKLPQQPGGKGWEP", "length": 113 }, "evidence": [ { "id": "Q3SZA2", "url": "https://omabrowser.org/oma/group/Q3SZA2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q0KI97-1", "protein_name": "Protein FMC1 homolog", "gene_name": "Dmel\\CG34117", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGTKVLRSLLHELRQASPNGCIKDSLAARYILAQYKKFATTEQQFCKARNEATFLGQTYLTYLASQRRYLELYKEYHGRGERSVRDTADLVGFKLPSDPK", "length": 101 }, "evidence": [ { "id": "Q3SZA2", "url": "https://omabrowser.org/oma/group/Q3SZA2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q4G012-1", "protein_name": "Protein FMC1 homolog", "gene_name": "Fmc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALGSPARTLRGLLRELRYLNAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIRQHVALHQEFHGKGERSVEESAGLVGLQLPHQPGGKGWEP", "length": 113 }, "evidence": [ { "id": "Q3SZA2", "url": "https://omabrowser.org/oma/group/Q3SZA2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96HJ9-1", "protein_name": "Protein FMC1 homolog", "gene_name": "FMC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALGSPSHTFRGLLRELRYLSAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIRKHVALHQEFHGKGERSVEESAGLVGLKLPHQPGGKGWEP", "length": 113 }, "evidence": [ { "id": "Q3SZA2", "url": "https://omabrowser.org/oma/group/Q3SZA2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR13-1", "protein_name": "Protein FMC1 homolog", "gene_name": "Fmc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALGSPARTLRGLLRELRYLNAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLSSIRQHVALHQEFHGKGERSVEESAGLVGLQLPRQPGGKGWEP", "length": 113 }, "evidence": [ { "id": "Q3SZA2", "url": "https://omabrowser.org/oma/group/Q3SZA2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial proton-transporting ATP synthase complex assembly", "id": "GO:0033615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033615", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA2", "url": "https://www.uniprot.org/uniprotkb/Q3SZA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 113, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZA2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZC0-1", "uniprot_ac": "Q3SZC0", "uniprot_id": "ERH_BOVIN", "mass": { "chemical_mass": 12259.0, "monoisotopic_mass": 12259.0 }, "refseq": { "ac": "NP_001029508", "name": "enhancer of rudimentary homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029508" }, "gene_names": [ { "name": "ERH", "type": "recommended", "evidence": [ { "id": "Q3SZC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0" } ] }, { "name": "ERH", "type": "synonym", "evidence": [ { "id": "NP_001029508", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029508" } ] } ], "protein_names": [ { "name": "Enhancer of rudimentary homolog", "type": "recommended", "evidence": [ { "id": "Q3SZC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0/entry#names_and_taxonomy" } ] }, { "name": "enhancer of rudimentary homolog", "type": "synonym", "evidence": [ { "id": "NP_001029508", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029508" } ] } ], "function": [ { "annotation": "May have a role in the cell cycle.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC0", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZC0", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERH", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0", "locus": { "chromosome": "10", "start_pos": 81171718, "end_pos": 81185845, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017798", "url": "https://www.ensembl.org/id/ENSBTAG00000017798" } ] } } ], "crossref": [ { "id": "Q3SZC0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017798", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508901", "url": "https://www.ncbi.nlm.nih.gov/gene/508901", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508901", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508901", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ESRTWSD", "url": "https://omabrowser.org/oma/group/ESRTWSD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZC0", "url": "https://www.orthodb.org/?gene=Q3SZC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12373", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12373", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12373:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12373:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029508", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZC0", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZC0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104, "header": "sp|Q3SZC0-1|ERH_BOVIN Isoform 1 of Enhancer of rudimentary homolog OS=Bos taurus OX=9913 GN=ERH PE=3 SV=1 CANONICAL=Q3SZC0-1" }, "isoforms": [ { "isoform_ac": "Q3SZC0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0/entry#Q3SZC0-1", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104, "header": "sp|Q3SZC0-1|ERH_BOVIN Isoform 1 of Enhancer of rudimentary homolog OS=Bos taurus OX=9913 GN=ERH PE=3 SV=1 CANONICAL=Q3SZC0-1" }, "locus": { "chromosome": "10", "start_pos": 81184975, "end_pos": 81172722, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023664.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023664.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023664.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023664.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC0", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0" } ], "site_lbl": "Thr11" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508901", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508901", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H9A7-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "LOC100768642", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6GLN9-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "Erh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "CCAQVREDIRIFIEVVFPLQSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 123 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NHW3-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "ERH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQASK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F2Z5J5-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "ERH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P84089-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "Erh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P84090-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "ERH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q24337-1", "protein_name": "Protein enhancer of rudimentary", "gene_name": "e(r)", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSHTILLVQPGARPETRTYCDYESVNECMEGVCKIYEEHLKRRNPNTPTITYDISQLFDFIDTMVDISCMVYQKSTNTYAPYNKDWIKEKIYVLLRQAAFSSNT", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q86A92-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "erh", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHTIVLLQTTMGKSSRTFMDYESVNQAIEGICNMYEQRLKQERPNQKNITYDISQLFKFIDSLADLSCLVYTSHINAYTPYNKEWIKTKIINHLQKLAQ", "length": 100 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q98874-1", "protein_name": "Enhancer of rudimentary homolog", "gene_name": "erh", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFVDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK", "length": 104 }, "evidence": [ { "id": "Q3SZC0", "url": "https://omabrowser.org/oma/group/Q3SZC0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC0", "url": "https://www.uniprot.org/uniprotkb/Q3SZC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZC0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZE2-1", "uniprot_ac": "Q3SZE2", "uniprot_id": "PFD1_BOVIN", "mass": { "chemical_mass": 14223.0, "monoisotopic_mass": 14223.0 }, "refseq": { "ac": "NP_001071530", "name": "prefoldin subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530" }, "gene_names": [ { "name": "PFDN1", "type": "recommended", "evidence": [ { "id": "Q3SZE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ] }, { "name": "PFDN1", "type": "synonym", "evidence": [ { "id": "NP_001071530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530" } ] } ], "protein_names": [ { "name": "Prefoldin subunit 1", "type": "recommended", "evidence": [ { "id": "Q3SZE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2/entry#names_and_taxonomy" } ] }, { "name": "prefoldin subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001071530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530" } ] } ], "function": [ { "annotation": "Antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo", "evidence": [ { "database": "RefSeq", "id": "NP_001071530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530" }, { "database": "PubMed", "id": "16415341", "url": "https://glygen.org/publication/PubMed/16415341" } ] }, { "annotation": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFDN1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2", "locus": { "chromosome": "7", "start_pos": 51426251, "end_pos": 51510386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051779", "url": "https://www.ensembl.org/id/ENSBTAG00000051779" } ] } } ], "crossref": [ { "id": "Q3SZE2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051779", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051779", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616553", "url": "https://www.ncbi.nlm.nih.gov/gene/616553", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616553", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616553", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REMIQQK", "url": "https://omabrowser.org/oma/group/REMIQQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZE2", "url": "https://www.orthodb.org/?gene=Q3SZE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20903:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20903:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZE2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPVDLELKKAFTELQAKVIDTQQKVKLADVQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHNQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122, "header": "sp|Q3SZE2-1|PFD1_BOVIN Isoform 1 of Prefoldin subunit 1 OS=Bos taurus OX=9913 GN=PFDN1 PE=2 SV=1 CANONICAL=Q3SZE2-1" }, "isoforms": [ { "isoform_ac": "Q3SZE2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2/entry#Q3SZE2-1", "sequence": { "sequence": "MAAPVDLELKKAFTELQAKVIDTQQKVKLADVQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHNQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122, "header": "sp|Q3SZE2-1|PFD1_BOVIN Isoform 1 of Prefoldin subunit 1 OS=Bos taurus OX=9913 GN=PFDN1 PE=2 SV=1 CANONICAL=Q3SZE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Stirling PC, Cuellar J, Alfaro GA, El Khadali F, Beh CT, Valpuesta JM, Melki R, Leroux MR", "evidence": [ { "database": "RefSeq", "id": "NP_001071530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071530" } ], "reference": [ { "type": "PubMed", "id": "16415341", "url": "https://glygen.org/publication/PubMed/16415341" } ] } ], "pathway": [ { "id": "bta:616553", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616553", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BED1-1", "protein_name": "Prefoldin subunit 1", "gene_name": "PFDN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHNQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MTB7-1", "protein_name": "Prefoldin subunit 1", "gene_name": "Pfdn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEVIHNQLLEKQKVAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZX38-1", "protein_name": "Prefoldin subunit 1", "gene_name": "Pfdn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEVIHNQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NDS5-1", "protein_name": "Prefoldin subunit 1", "gene_name": "PFDN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPLDLELKKAFTELQAKVIDTQQKVKLADIQIEQLSKTKKHAHLTDTEIMTLVDETRMYEGVGRMFILQSKGVIHNQLLEKQRIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O60925-1", "protein_name": "Prefoldin subunit 1", "gene_name": "PFDN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54JS0-1", "protein_name": "Probable prefoldin subunit 1", "gene_name": "pfdn1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEILDKQAFFETREKLYTLSRSLNIIKQRIQIAENDRKKCLITINELESLSSETKTYKAVGKMFVISPMTSLKTELKQQVQKDEEDVKGLINQSKYIDAQITDTERSLNELVRKK", "length": 115 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5D016-1", "protein_name": "Prefoldin subunit 1", "gene_name": "pfdn1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPVDLELKKAFAELQAKMVDTQQKVKLADLQIEQLSRVKKHANLTHGEITSLPESTRMFEGAGRMFILQSKGEISNQLLEKQKTADDKIKELEQKKTYLERSVKDAEDNIREMLMSRRAQ", "length": 122 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q94AF7-1", "protein_name": "Prefoldin subunit 1", "gene_name": "PFD1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADEATRAAFMEIQASMIELTGKLKQVQNQMRNKEGDRKRAFLTLEELRPLPEETNTYKSIGRTFVLEPKTVLEGEQEQKLKDSEAAVASLQTSKEYLEKQVAEVENNLRELLQQEPGIAQQIMSMSM", "length": 128 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VMH8-1", "protein_name": "Prefoldin 1, isoform A", "gene_name": "Pfdn1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAQMDIELKKAFTEMQINKLETTKKIHMIDMKCDMVKTGKQKYQLTEKGTSSLADDTRVYQSVGRMFLLTDVQNMREDLKARQEKCDKAIELLEKKKEFLQKSLKSQEDGLRELVQQRKEADQTAK", "length": 126 }, "evidence": [ { "id": "Q3SZE2", "url": "https://omabrowser.org/oma/group/Q3SZE2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE2", "url": "https://www.uniprot.org/uniprotkb/Q3SZE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 122, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZF0-1", "uniprot_ac": "Q3SZF0", "uniprot_id": "ACBD7_BOVIN", "mass": { "chemical_mass": 10035.0, "monoisotopic_mass": 10035.0 }, "refseq": { "ac": "NP_001106768", "name": "acyl-CoA-binding domain-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" }, "gene_names": [ { "name": "ACBD7", "type": "recommended", "evidence": [ { "id": "Q3SZF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0" } ] }, { "name": "ACBD7", "type": "synonym", "evidence": [ { "id": "NP_001106768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" } ] } ], "protein_names": [ { "name": "Acyl-CoA-binding domain-containing protein 7", "type": "recommended", "evidence": [ { "id": "Q3SZF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0/entry#names_and_taxonomy" } ] }, { "name": "acyl-CoA-binding domain-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001106768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" } ] }, { "name": "acyl-Coenzyme A binding domain containing 7", "type": "synonym", "evidence": [ { "id": "NP_001106768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" } ] } ], "function": [ { "annotation": "Binds medium- and long-chain acyl-CoA esters.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF0", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0#function" } ] }, { "annotation": "The dimerization property of helix A4 (HA4) of acyl-coenzyme-A-binding protein (ACBP) is maintained in the full-length protein under denaturing conditions, emphasizing the special role of HA4 in structure formation during the denatured state of ACBP.", "evidence": [ { "database": "RefSeq", "id": "NP_001106768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" }, { "database": "PubMed", "id": "15683223", "url": "https://glygen.org/publication/PubMed/15683223" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZF0", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACBD7", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0", "locus": {} } ], "crossref": [ { "id": "Q3SZF0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002858", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002858", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00435", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00435", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508284", "url": "https://www.ncbi.nlm.nih.gov/gene/508284", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000582", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000582", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508284", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508284", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IACPAML", "url": "https://omabrowser.org/oma/group/IACPAML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZF0", "url": "https://www.orthodb.org/?gene=Q3SZF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23310", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23310", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23310:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23310:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00887", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00887", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-77289", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001106768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NY15", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY15-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4S5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4S5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZF0", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZF0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLQADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI", "length": 88, "header": "sp|Q3SZF0-1|ACBD7_BOVIN Isoform 1 of Acyl-CoA-binding domain-containing protein 7 OS=Bos taurus OX=9913 GN=ACBD7 PE=3 SV=1 CANONICAL=Q3SZF0-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NY15-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0/entry#A0ABI0NY15-1", "sequence": { "sequence": "MEPEKFHSLLSASWKPGKLVMSFQSKPNGLIIMGADSLKISFQGQEKADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI", "length": 131, "header": "tr|A0ABI0NY15-1|A0ABI0NY15_BOVIN Computationally mapped isoform of Acyl-CoA binding domain containing 7 OS=Bos taurus OX=9913 GN=ACBD7 PE=4 SV=1 CANONICAL=Q3SZF0-1" }, "locus": { "chromosome": "13", "start_pos": 29671240, "end_pos": 29655365, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104759.1" } ] } }, { "isoform_ac": "A0ABI0P4S5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0/entry#A0ABI0P4S5-1", "sequence": { "sequence": "GRACWRDGLALGPALEWVFLLCLADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI", "length": 107, "header": "tr|A0ABI0P4S5-1|A0ABI0P4S5_BOVIN Computationally mapped isoform of Acyl-CoA binding domain containing 7 OS=Bos taurus OX=9913 GN=ACBD7 PE=4 SV=1 CANONICAL=Q3SZF0-1" }, "locus": { "chromosome": "13", "start_pos": 29658086, "end_pos": 29655365, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106586.1" } ] } }, { "isoform_ac": "Q3SZF0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0/entry#Q3SZF0-1", "sequence": { "sequence": "MSLQADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI", "length": 88, "header": "sp|Q3SZF0-1|ACBD7_BOVIN Isoform 1 of Acyl-CoA-binding domain-containing protein 7 OS=Bos taurus OX=9913 GN=ACBD7 PE=3 SV=1 CANONICAL=Q3SZF0-1" }, "locus": { "chromosome": "13", "start_pos": 29660392, "end_pos": 29655365, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105330.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Reversible dimerization of acid-denatured ACBP controlled by helix A4.", "journal": "Biochemistry", "date": "2005-02-08", "authors": "Fieber Wolfgang, Kragelund Birthe B, Meldal Morten, Poulsen Flemming M", "evidence": [ { "database": "RefSeq", "id": "NP_001106768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106768" } ], "reference": [ { "type": "PubMed", "id": "15683223", "url": "https://glygen.org/publication/PubMed/15683223" } ] } ], "pathway": [ { "id": "bta:508284", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508284", "resource": "KEGG Pathway" }, { "id": "R-BTA-77289", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "resource": "Reactome", "description": "Mitochondrial Fatty Acid Beta-Oxidation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJN9-1", "protein_name": "Acyl-CoA binding domain containing 7", "gene_name": "ACBD7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLQADFDKATEDVRKLKTRPDDQELKELYGLYKQSIIGDIDIECPAMIDLKGKAKWEAWNLQKGLSKEDAMSAYISKAKELIEKYGI", "length": 88 }, "evidence": [ { "id": "Q3SZF0", "url": "https://omabrowser.org/oma/group/Q3SZF0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LDR0-1", "protein_name": "Acyl-CoA-binding domain-containing protein 7", "gene_name": "Acbd7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLQADFDQAAQDVRKLKSRPEDEELKELYGLYKQSIIGDINIACPAMLDLKGKAKWEAWSLQKGLSKEDAMSAYISKARELIEKYGI", "length": 88 }, "evidence": [ { "id": "Q3SZF0", "url": "https://omabrowser.org/oma/group/Q3SZF0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XHQ8-1", "protein_name": "Acyl-CoA binding domain containing 7", "gene_name": "ACBD7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "PSADFDGAAKDVKKLKTRPTDEELKELYGFYKQATVGDINIECPGVLDVKGKAKWEAWNLKRGISKEDAMNAYISKAKAMIEKYGI", "length": 86 }, "evidence": [ { "id": "Q3SZF0", "url": "https://omabrowser.org/oma/group/Q3SZF0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8N6N7-1", "protein_name": "Acyl-CoA-binding domain-containing protein 7", "gene_name": "ACBD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALQADFDRAAEDVRKLKARPDDGELKELYGLYKQAIVGDINIACPGMLDLKGKAKWEAWNLKKGLSTEDATSAYISKAKELIEKYGI", "length": 88 }, "evidence": [ { "id": "Q3SZF0", "url": "https://omabrowser.org/oma/group/Q3SZF0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D258-1", "protein_name": "Acyl-CoA-binding domain-containing protein 7", "gene_name": "Acbd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLQADFDQAAQDVRKLKSRPEDEELKELYGLYKQSVIGDINIACPAMLDLKGKAKWEAWNLQKGLSKEDAMCAYISKARELIEKYGI", "length": 88 }, "evidence": [ { "id": "Q3SZF0", "url": "https://omabrowser.org/oma/group/Q3SZF0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF0", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "fatty-acyl-CoA binding", "id": "GO:0000062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000062", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF0", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZF0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 88, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZF0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZF0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF0" }, { "id": "PRU00573", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00573" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ACB", "eco_id": "ECO_0000255", "start_pos": 3, "end_pos": 88, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZI7-1", "uniprot_ac": "Q3SZI7", "uniprot_id": "COG6_BOVIN", "mass": { "chemical_mass": 73302.0, "monoisotopic_mass": 73302.0 }, "refseq": { "ac": "NP_001030241", "name": "conserved oligomeric Golgi complex subunit 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030241" }, "gene_names": [ { "name": "COG6", "type": "recommended", "evidence": [ { "id": "Q3SZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ] }, { "name": "COG6", "type": "synonym", "evidence": [ { "id": "NP_001030241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030241" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 6", "type": "recommended", "evidence": [ { "id": "Q3SZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7/entry#names_and_taxonomy" } ] }, { "name": "COG complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001030241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030241" }, { "id": "Q3SZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 6", "type": "synonym", "evidence": [ { "id": "Q3SZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7/entry#names_and_taxonomy" } ] }, { "name": "conserved oligomeric Golgi complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001030241", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030241" } ] } ], "function": [ { "annotation": "Required for normal Golgi function.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG6", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7", "locus": { "chromosome": "12", "start_pos": 22698525, "end_pos": 22753200, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016635", "url": "https://www.ensembl.org/id/ENSBTAG00000016635" } ] } } ], "crossref": [ { "id": "Q3SZI7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "509305", "url": "https://www.ncbi.nlm.nih.gov/gene/509305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZI7", "url": "https://www.orthodb.org/?gene=Q3SZI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21506", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21506", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21506:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21506:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06419", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06419", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030241", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZI7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQGPLANLPNLDSVALKAAMVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 657, "header": "sp|Q3SZI7-1|COG6_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=2 SV=1 CANONICAL=Q3SZI7-1" }, "isoforms": [ { "isoform_ac": "Q3SZI7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7/entry#Q3SZI7-1", "sequence": { "sequence": "MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQGPLANLPNLDSVALKAAMVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 657, "header": "sp|Q3SZI7-1|COG6_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=2 SV=1 CANONICAL=Q3SZI7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 293, "start_aa": "Thr", "end_pos": 293, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr293", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509305", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "pmid": "" }, { "name": "retrograde transport, vesicle recycling within Golgi", "id": "GO:0000301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000301", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI7", "url": "https://www.uniprot.org/uniprotkb/Q3SZI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 657, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZI7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 293 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 443, "end_pos": 445 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZK0-1", "uniprot_ac": "Q3SZK0", "uniprot_id": "S2534_BOVIN", "mass": { "chemical_mass": 32258.0, "monoisotopic_mass": 32258.0 }, "refseq": { "ac": "NP_001029669", "name": "solute carrier family 25 member 34", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029669" }, "gene_names": [ { "name": "SLC25A34", "type": "recommended", "evidence": [ { "id": "Q3SZK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0" } ] }, { "name": "SLC25A34", "type": "synonym", "evidence": [ { "id": "NP_001029669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029669" } ] } ], "protein_names": [ { "name": "Solute carrier family 25 member 34", "type": "recommended", "evidence": [ { "id": "Q3SZK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 25 member 34", "type": "synonym", "evidence": [ { "id": "NP_001029669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029669" } ] } ], "function": [ { "annotation": "Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK0", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0#function" }, { "database": "UniProtKB", "id": "Q6PIV7", "url": "https://www.uniprot.org/uniprotkb/Q6PIV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZK0", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC25A34", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0", "locus": { "chromosome": "16", "start_pos": 51819920, "end_pos": 51824310, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018723", "url": "https://www.ensembl.org/id/ENSBTAG00000018723" } ] } } ], "crossref": [ { "id": "Q3SZK0", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018723", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018723", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515553", "url": "https://www.ncbi.nlm.nih.gov/gene/515553", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515553", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515553", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KANCEDH", "url": "https://omabrowser.org/oma/group/KANCEDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZK0", "url": "https://www.orthodb.org/?gene=Q3SZK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45928", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45928", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45928:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45928:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "76595", "url": "https://www.rhea-db.org/rhea/76595", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZK0", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZK0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQKRGTYPRLYRGFVASVVAVVRADGLCGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLSQQPGGTVVAGAVAGALGAFVGSPAYLVKTQLQAQTVAAMAVGHQHHHESLLGALETIWRQQGLAGLWRGVGGAVPRVMVGSAAQLATFASAKAWVQERQWLPEDSWLVALAGGMISSIAVVAVMTPFDVVSTRLYNQPVDGAGRGKLYGGLTDCLVKIWRQEGPLALYKGLGPVYLRLGPHTILSMLFWDELRKLAGWGQHQGS", "length": 304, "header": "sp|Q3SZK0-1|S2534_BOVIN Isoform 1 of Solute carrier family 25 member 34 OS=Bos taurus OX=9913 GN=SLC25A34 PE=2 SV=1 CANONICAL=Q3SZK0-1" }, "isoforms": [ { "isoform_ac": "Q3SZK0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0/entry#Q3SZK0-1", "sequence": { "sequence": "METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQKRGTYPRLYRGFVASVVAVVRADGLCGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLSQQPGGTVVAGAVAGALGAFVGSPAYLVKTQLQAQTVAAMAVGHQHHHESLLGALETIWRQQGLAGLWRGVGGAVPRVMVGSAAQLATFASAKAWVQERQWLPEDSWLVALAGGMISSIAVVAVMTPFDVVSTRLYNQPVDGAGRGKLYGGLTDCLVKIWRQEGPLALYKGLGPVYLRLGPHTILSMLFWDELRKLAGWGQHQGS", "length": 304, "header": "sp|Q3SZK0-1|S2534_BOVIN Isoform 1 of Solute carrier family 25 member 34 OS=Bos taurus OX=9913 GN=SLC25A34 PE=2 SV=1 CANONICAL=Q3SZK0-1" }, "locus": { "chromosome": "16", "start_pos": 51824136, "end_pos": 51821493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024921.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024921.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024921.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024921.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515553", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515553", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NWQ1-1", "protein_name": "Solute carrier family 25 member 34", "gene_name": "SLC25A34", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGTGALGPFPAAALHDFPYPSQTAAPVSHGPPAGGVPPAADLVLGAAAGCMACVLTNPLEVVKTRLQLQGELRAPGTYPRPYRGVLRAVGAVCRADGLRGLQKGLAAGLLYQGLMNGVRFYCYSCALDAGWTGWPGGTVVAGAVAGAVGAFVGSPAYLVKTHLQAQTLSAMAVGHQHNHESISDAFGSIYRQHGVAGLWRGVSGAVPRVAVGSAAQLATFASAKDWVCQHQWFGEGSWAAVLAGGMVSGVAVAVTMTPFDVVSTRLYNQPVEADGTGKLYRGFLDCFAQISSKEGLLGLYKGIGAVYLRLGPHTVLSLFFWDELRRMVRPQPPPGP", "length": 338 }, "evidence": [ { "id": "Q3SZK0", "url": "https://omabrowser.org/oma/group/Q3SZK0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2MUF0-1", "protein_name": "Solute carrier family 25 member 34", "gene_name": "Slc25a34", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPTMDAEDMVSPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQAPGTYPRPYRGFVSSVAAVARADGLWGLQKGLAAGLLYQGLMNSVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYLVKTQLQAQTVAALAVGHQHQHQSVLGALETIWRQQGLLGLWRGVGGAVPRVTVGSAAQLATFASAKAWVQERQWFLEDSWLVTLTGGMISSIAVAAVMTPFDVVSTRLYNQPVDRAGRGQLYGGLADCLVKICQQEGPLALYKGLGLAYLRLGPHTILSMFFWDELRKLAARAQR", "length": 308 }, "evidence": [ { "id": "Q3SZK0", "url": "https://omabrowser.org/oma/group/Q3SZK0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2ADF7-1", "protein_name": "Solute carrier family 25 member 34", "gene_name": "Slc25a34", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPTQAQMAPAMDSREMVSPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQAPGTYPRPYRGFVSSVAAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAAAGALGAFVGSPAYLVKTQLQAQTVATMAVGHQHQHQGVLSALETIWRQQGMLGLWRGVGGAVPRVTVGSAAQLATFTSAKAWVQDRQWFLEDSWLVTLAGGMISSIAVVAVMTPLDVVSTRLYNQPVDRAGRGQLYGGLADCLVKTCQQEGPLALYKGLGPAYLRLGPHTILSMFFWDELRKLVARAQHQGT", "length": 318 }, "evidence": [ { "id": "Q3SZK0", "url": "https://omabrowser.org/oma/group/Q3SZK0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PIV7-1", "protein_name": "Solute carrier family 25 member 34", "gene_name": "SLC25A34", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQHKGT", "length": 304 }, "evidence": [ { "id": "Q3SZK0", "url": "https://omabrowser.org/oma/group/Q3SZK0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK0", "url": "https://www.uniprot.org/uniprotkb/Q3SZK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "76595", "name": "", "equation": "a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "76595", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76595" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZK0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 304, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZK0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZK0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZL5-1", "uniprot_ac": "Q3SZL5", "uniprot_id": "PIGS_BOVIN", "mass": { "chemical_mass": 61786.0, "monoisotopic_mass": 61786.0 }, "refseq": { "ac": "NP_001029388", "name": "GPI-anchor transamidase component PIGS", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" }, "gene_names": [ { "name": "PIGS", "type": "recommended", "evidence": [ { "id": "Q3SZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5" } ] }, { "name": "PIGS", "type": "synonym", "evidence": [ { "id": "NP_001029388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" } ] } ], "protein_names": [ { "name": "GPI-anchor transamidase component PIGS", "type": "recommended", "evidence": [ { "id": "Q3SZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5/entry#names_and_taxonomy" } ] }, { "name": "GPI transamidase component PIG-S", "type": "synonym", "evidence": [ { "id": "NP_001029388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" } ] }, { "name": "GPI-anchor transamidase component PIGS", "type": "synonym", "evidence": [ { "id": "NP_001029388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class S protein", "type": "synonym", "evidence": [ { "id": "Q3SZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol glycan, class S", "type": "synonym", "evidence": [ { "id": "NP_001029388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" } ] }, { "name": "phosphatidylinositol-glycan biosynthesis class S protein", "type": "synonym", "evidence": [ { "id": "NP_001029388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388" } ] } ], "function": [ { "annotation": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5#function" }, { "database": "UniProtKB", "id": "Q96S52", "url": "https://www.uniprot.org/uniprotkb/Q96S52#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGS", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5", "locus": { "chromosome": "19", "start_pos": 20016185, "end_pos": 20028279, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013098", "url": "https://www.ensembl.org/id/ENSBTAG00000013098" } ] } } ], "crossref": [ { "id": "Q3SZL5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "504583", "url": "https://www.ncbi.nlm.nih.gov/gene/504583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504583", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504583", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZL5", "url": "https://www.orthodb.org/?gene=Q3SZL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21072", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21072", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21072:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21072:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10510", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10510", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029388", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATGAAATDLEVVRGKRAALFFATVVIVLGLPLWWKTTETYRAPLPYSQISGLNSLKLRLMVPVTVVFTQESVPLDDQEKLPFTVVHEREIPLKYKLKIKCRFQKAYRRALDHEEAALSLGNIQEAEAMLAEPSEQAEGSLTVYVISERCSLLPQDMMSYIGPKRMAVVRGITHREAFNIIGRRIIQVVQAMSLTEDVLAAALADHLPEDKWSSDKRRPLKSSLGYEITFSLLNPDPKSHDVHWDIEGAVRRYVQPFLSALSAAGNFSVDSQILYYAVLGVNPRFDSASSSYYLAAHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDPKAYNGSQLPVRVEVDMMRVMEVFLAQLRLLFGIAQPQLPPKCLFFGPKSEGIMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYRAVAAVQKAAEELSSGHLASAFAASQEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLFKIFLETRKSWKKPEKTD", "length": 555, "header": "sp|Q3SZL5-1|PIGS_BOVIN Isoform 1 of GPI-anchor transamidase component PIGS OS=Bos taurus OX=9913 GN=PIGS PE=2 SV=3 CANONICAL=Q3SZL5-1" }, "isoforms": [ { "isoform_ac": "Q3SZL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5/entry#Q3SZL5-1", "sequence": { "sequence": "MAATGAAATDLEVVRGKRAALFFATVVIVLGLPLWWKTTETYRAPLPYSQISGLNSLKLRLMVPVTVVFTQESVPLDDQEKLPFTVVHEREIPLKYKLKIKCRFQKAYRRALDHEEAALSLGNIQEAEAMLAEPSEQAEGSLTVYVISERCSLLPQDMMSYIGPKRMAVVRGITHREAFNIIGRRIIQVVQAMSLTEDVLAAALADHLPEDKWSSDKRRPLKSSLGYEITFSLLNPDPKSHDVHWDIEGAVRRYVQPFLSALSAAGNFSVDSQILYYAVLGVNPRFDSASSSYYLAAHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDPKAYNGSQLPVRVEVDMMRVMEVFLAQLRLLFGIAQPQLPPKCLFFGPKSEGIMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYRAVAAVQKAAEELSSGHLASAFAASQEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLFKIFLETRKSWKKPEKTD", "length": 555, "header": "sp|Q3SZL5-1|PIGS_BOVIN Isoform 1 of GPI-anchor transamidase component PIGS OS=Bos taurus OX=9913 GN=PIGS PE=2 SV=3 CANONICAL=Q3SZL5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 267, "start_aa": "Asn", "end_pos": 267, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn267", "evidence": [ { "id": "Q3SZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 370, "start_aa": "Asn", "end_pos": 370, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn370", "evidence": [ { "id": "Q3SZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504583", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504583", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5" } ], "pmid": "" }, { "name": "attachment of GPI anchor to protein", "id": "GO:0016255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016255", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "GPI-anchor transamidase complex", "id": "GO:0042765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042765", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL5", "url": "https://www.uniprot.org/uniprotkb/Q3SZL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 555, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZL5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 267, 370 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 267, "end_pos": 269 }, { "start_pos": 370, "end_pos": 372 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZL9-1", "uniprot_ac": "Q3SZL9", "uniprot_id": "TM50B_BOVIN", "mass": { "chemical_mass": 17936.0, "monoisotopic_mass": 17936.0 }, "refseq": { "ac": "NP_001029958", "name": "transmembrane protein 50B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029958" }, "gene_names": [ { "name": "TMEM50B", "type": "recommended", "evidence": [ { "id": "Q3SZL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9" } ] }, { "name": "TMEM50B", "type": "synonym", "evidence": [ { "id": "NP_001029958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029958" } ] } ], "protein_names": [ { "name": "Transmembrane protein 50B", "type": "recommended", "evidence": [ { "id": "Q3SZL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 50B", "type": "synonym", "evidence": [ { "id": "NP_001029958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029958" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZL9", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM50B", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9", "locus": { "chromosome": "1", "start_pos": 2083566, "end_pos": 2046733, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001258", "url": "https://www.ensembl.org/id/ENSBTAG00000001258" } ] } } ], "crossref": [ { "id": "Q3SZL9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001258", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001258", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615627", "url": "https://www.ncbi.nlm.nih.gov/gene/615627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615627", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LWIMFAD", "url": "https://omabrowser.org/oma/group/LWIMFAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZL9", "url": "https://www.orthodb.org/?gene=Q3SZL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029958", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZL9", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZL9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT", "length": 158, "header": "sp|Q3SZL9-1|TM50B_BOVIN Isoform 1 of Transmembrane protein 50B OS=Bos taurus OX=9913 GN=TMEM50B PE=2 SV=1 CANONICAL=Q3SZL9-1" }, "isoforms": [ { "isoform_ac": "Q3SZL9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9/entry#Q3SZL9-1", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT", "length": 158, "header": "sp|Q3SZL9-1|TM50B_BOVIN Isoform 1 of Transmembrane protein 50B OS=Bos taurus OX=9913 GN=TMEM50B PE=2 SV=1 CANONICAL=Q3SZL9-1" }, "locus": { "chromosome": "1", "start_pos": 2082133, "end_pos": 2065204, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001660.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001660.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001660.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001660.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615627", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615627", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I5Y6-1", "protein_name": "Transmembrane protein 50B isoform X1", "gene_name": "Tmem50b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNIDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT", "length": 158 }, "evidence": [ { "id": "Q3SZL9", "url": "https://omabrowser.org/oma/group/Q3SZL9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A1L1RX69-1", "protein_name": "Transmembrane protein 50B", "gene_name": "TMEM50B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAIASIVAGVLFFTGWWIMIDAAVVYPKPEQMNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYSDGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTNVYPGLAVFFQNALIFFSTLIYKFGRTEELWG", "length": 158 }, "evidence": [ { "id": "Q3SZL9", "url": "https://omabrowser.org/oma/group/Q3SZL9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1U1L0-1", "protein_name": "Transmembrane protein 50B", "gene_name": "TMEM50B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT", "length": 158 }, "evidence": [ { "id": "Q3SZL9", "url": "https://omabrowser.org/oma/group/Q3SZL9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P56557-1", "protein_name": "Transmembrane protein 50B", "gene_name": "TMEM50B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT", "length": 158 }, "evidence": [ { "id": "Q3SZL9", "url": "https://omabrowser.org/oma/group/Q3SZL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D1X9-1", "protein_name": "Transmembrane protein 50B", "gene_name": "Tmem50b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGFLDNFRWPECECIDWSERRNTVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNIDVYPGLAVFFQNALIFFSTLIYKFGRTEELWA", "length": 158 }, "evidence": [ { "id": "Q3SZL9", "url": "https://omabrowser.org/oma/group/Q3SZL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL9", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL9", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "late endosome to vacuole transport via multivesicular body sorting pathway", "id": "GO:0032511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032511", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL9", "url": "https://www.uniprot.org/uniprotkb/Q3SZL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 158, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZM6-1", "uniprot_ac": "Q3SZM6", "uniprot_id": "COXM1_BOVIN", "mass": { "chemical_mass": 12593.0, "monoisotopic_mass": 12593.0 }, "refseq": { "ac": "NP_001070016", "name": "COX assembly mitochondrial protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070016" }, "gene_names": [ { "name": "CMC1", "type": "recommended", "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" } ] }, { "name": "CMC1", "type": "synonym", "evidence": [ { "id": "NP_001070016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070016" } ] } ], "protein_names": [ { "name": "COX assembly mitochondrial protein homolog", "type": "recommended", "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6/entry#names_and_taxonomy" } ] }, { "name": "COX assembly mitochondrial protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001070016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070016" } ] }, { "name": "Cmc1p", "type": "synonym", "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6/entry#names_and_taxonomy" } ] }, { "name": "cmc1p", "type": "synonym", "evidence": [ { "id": "NP_001070016", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070016" } ] } ], "function": [ { "annotation": "Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM6", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZM6", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CMC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6", "locus": { "chromosome": "22", "start_pos": 2754961, "end_pos": 2675935, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035286", "url": "https://www.ensembl.org/id/ENSBTAG00000035286" } ] } } ], "crossref": [ { "id": "Q3SZM6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767824", "url": "https://www.ncbi.nlm.nih.gov/gene/767824", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767824", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767824", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCQETGF", "url": "https://omabrowser.org/oma/group/CCQETGF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZM6", "url": "https://www.orthodb.org/?gene=Q3SZM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22977:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22977:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070016", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZM6", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZM6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALDPSEQHLRHVEKDVLIPKIMREKARERCSEQVQDFTKCCKDSGVLMVVKCRKENSALKDCLTSYYKDPAFYEECKMEYLKEREEFRRTGIPTKKRLQKLPTSM", "length": 106, "header": "sp|Q3SZM6-1|COXM1_BOVIN Isoform 1 of COX assembly mitochondrial protein homolog OS=Bos taurus OX=9913 GN=CMC1 PE=3 SV=1 CANONICAL=Q3SZM6-1" }, "isoforms": [ { "isoform_ac": "Q3SZM6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6/entry#Q3SZM6-1", "sequence": { "sequence": "MALDPSEQHLRHVEKDVLIPKIMREKARERCSEQVQDFTKCCKDSGVLMVVKCRKENSALKDCLTSYYKDPAFYEECKMEYLKEREEFRRTGIPTKKRLQKLPTSM", "length": 106, "header": "sp|Q3SZM6-1|COXM1_BOVIN Isoform 1 of COX assembly mitochondrial protein homolog OS=Bos taurus OX=9913 GN=CMC1 PE=3 SV=1 CANONICAL=Q3SZM6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767824", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767824", "resource": "KEGG Pathway" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8Q586-1", "protein_name": "COX assembly mitochondrial protein", "gene_name": "cmc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPPKAEEPHLRHVERDVLIPKMMREKAKERCVQQVDAFNVCCKDSGFFMVFKCREENAALKECLTQHYRDPVFFEECKQEYLKEKLQYEQTGVPTKSRKQKLPTSM", "length": 107 }, "evidence": [ { "id": "Q3SZM6", "url": "https://omabrowser.org/oma/group/Q3SZM6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XHF8-1", "protein_name": "COX assembly mitochondrial protein", "gene_name": "CMC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKYCISQCIESKQMSKGTAVTPFTLWITHCCLMTPRLSCVSFGCHLDQRRAPTSSCVLLIAFTKCCKETGFLMVVKCREENTALKDCLVGHYADPSFYEECKAEYLKQREEYRATGIKKKRQKITSNV", "length": 128 }, "evidence": [ { "id": "Q3SZM6", "url": "https://omabrowser.org/oma/group/Q3SZM6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZTN2-1", "protein_name": "C-x(9)-C motif containing 1", "gene_name": "Cmc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "EQGKGVWSVLTAEVAHPLSCGKLRAGERLRAQSSLGSSPSRLQSRRVACCFSALRDGAGPRRYWGRRGCEGLGARGQVLQGCVASAVSTSFSPAAGFPLSVTGRPSAARWGSSCSHLRHVEKDVLIPKIMREKARERCSEQVEDFTRCCKDSGILMVLKCRKENSALKDCLTAYYNDPAFYEECKLEYLKEREEFRRTGVPTKKRLQKLPTSM", "length": 213 }, "evidence": [ { "id": "Q3SZM6", "url": "https://omabrowser.org/oma/group/Q3SZM6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z7K0-1", "protein_name": "COX assembly mitochondrial protein homolog", "gene_name": "CMC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSALKECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM", "length": 106 }, "evidence": [ { "id": "Q3SZM6", "url": "https://omabrowser.org/oma/group/Q3SZM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CPZ8-1", "protein_name": "COX assembly mitochondrial protein homolog", "gene_name": "Cmc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALDPAEQHLRHVEKDVLIPKIIREKARERCSEQVEDFTRCCKDSGILMVLKCRKENSALKDCLTAYYNDPAFYEECKLEYLKEREEFRKTGVPTKKRLQKLPTNM", "length": 106 }, "evidence": [ { "id": "Q3SZM6", "url": "https://omabrowser.org/oma/group/Q3SZM6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM6", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM6", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZM6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 106, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZM6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZM6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000255", "start_pos": 28, "end_pos": 71, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 1", "eco_id": "ECO_0000255", "start_pos": 31, "end_pos": 41, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM6" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif 2", "eco_id": "ECO_0000255", "start_pos": 53, "end_pos": 63, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZQ3-1", "uniprot_ac": "Q3SZQ3", "uniprot_id": "SPT19_BOVIN", "mass": { "chemical_mass": 17899.0, "monoisotopic_mass": 17899.0 }, "refseq": { "ac": "NP_001069966", "name": "spermatogenesis-associated protein 19, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069966" }, "gene_names": [ { "name": "SPATA19", "type": "recommended", "evidence": [ { "id": "Q3SZQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ] }, { "name": "SPATA19", "type": "synonym", "evidence": [ { "id": "NP_001069966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069966" } ] } ], "protein_names": [ { "name": "Spermatogenesis-associated protein 19, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3SZQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 19, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001069966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069966" } ] }, { "name": "spermatogenesis-associated protein 19, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001069966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069966" } ] } ], "function": [ { "annotation": "Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3#function" }, { "database": "UniProtKB", "id": "Q9DAQ9", "url": "https://www.uniprot.org/uniprotkb/Q9DAQ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA19", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3", "locus": { "chromosome": "29", "start_pos": 33207406, "end_pos": 33201867, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014651", "url": "https://www.ensembl.org/id/ENSBTAG00000014651" } ] } } ], "crossref": [ { "id": "Q3SZQ3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014651", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014651", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618276", "url": "https://www.ncbi.nlm.nih.gov/gene/618276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHWLKKT", "url": "https://omabrowser.org/oma/group/EHWLKKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZQ3", "url": "https://www.orthodb.org/?gene=Q3SZQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36468:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36468:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIITTWIVYILARKGAGLPFPPKVSSDVEVTETEAVSVVQHWLKKTEEEASQEIKEKMSTNFPPMQGQDVHVTRDVVKHHLSKSGLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEARNEAMRDRIEQVRRSICHLSDEISQELRNRNSYSEC", "length": 154, "header": "sp|Q3SZQ3-1|SPT19_BOVIN Isoform 1 of Spermatogenesis-associated protein 19, mitochondrial OS=Bos taurus OX=9913 GN=SPATA19 PE=2 SV=1 CANONICAL=Q3SZQ3-1" }, "isoforms": [ { "isoform_ac": "Q3SZQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3/entry#Q3SZQ3-1", "sequence": { "sequence": "MIITTWIVYILARKGAGLPFPPKVSSDVEVTETEAVSVVQHWLKKTEEEASQEIKEKMSTNFPPMQGQDVHVTRDVVKHHLSKSGLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEARNEAMRDRIEQVRRSICHLSDEISQELRNRNSYSEC", "length": 154, "header": "sp|Q3SZQ3-1|SPT19_BOVIN Isoform 1 of Spermatogenesis-associated protein 19, mitochondrial OS=Bos taurus OX=9913 GN=SPATA19 PE=2 SV=1 CANONICAL=Q3SZQ3-1" }, "locus": { "chromosome": "29", "start_pos": 33206120, "end_pos": 33201930, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019506.3", "url": "https://www.ensembl.org/id/ENSBTAT00000019506.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019506.2", "url": "https://www.ensembl.org/id/ENSBTAP00000019506.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 116, "end_pos": 116, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "site_lbl": "Ser116" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "site_lbl": "Ser26" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618276", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M3U5-1", "protein_name": "Spermatogenesis-associated protein 19, mitochondrial isoform X1", "gene_name": "Spata19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIITTWIVYIFTRKTIGLPFPPNTNSDIEVVESEAVSVVQHWLNKTEEEASRSIKEKMSNNAPSCHGHDVHVTRDLVKHHLSKSDMSVEPNQELLEERTRIQFIRWSHTRIFQVPSEMIEDVMQERIDQVRRSISHLTCDSYDDPSFRTSCSEC", "length": 154 }, "evidence": [ { "id": "Q3SZQ3", "url": "https://omabrowser.org/oma/group/Q3SZQ3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LDJ2-1", "protein_name": "Spermatogenesis associated 19", "gene_name": "SPATA19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIITTWIVYILARKHTGFPFPPKVSSDVEVVESEAVSVVQHWLKKTEEEASQDIKEKMSASCPPTHGQDVHVTRDVVKHRLSKSGLLTNQSQEVLEERTRIQFIRWSHTRIFQVPSEVRNEVMRDRIEQVRRSMCHLTDESSQELRDRNSCKDC", "length": 154 }, "evidence": [ { "id": "Q3SZQ3", "url": "https://omabrowser.org/oma/group/Q3SZQ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Z5L4-1", "protein_name": "Spermatogenesis-associated protein 19, mitochondrial", "gene_name": "SPATA19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIITTWIVYILARKGVGLPFLPITSSDIDVVESEAVSVLHHWLKKTEEEASRGIKEKLSINHPSQGVREKMSTDSPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEMTEDIMRDRIEQVRRSISRLTDVSAQDFSMRPSSSDC", "length": 167 }, "evidence": [ { "id": "Q3SZQ3", "url": "https://omabrowser.org/oma/group/Q3SZQ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q920Q3-1", "protein_name": "Spermatogenesis-associated protein 19, mitochondrial", "gene_name": "Spata19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIITTWIMYILARKSIGLPFPPRVNSDIEVEETEAVSVVQHWLNKTEEEASRSIKEKISINDPCTQGHDIHVTRDLVKHRLSKCDMLTDPNQEVLEERTRIQFIRWSHTRIFQVPSEMMDDVIQERIDQVRRSVSHLRCDSSSDPCYRNSCSEC", "length": 154 }, "evidence": [ { "id": "Q3SZQ3", "url": "https://omabrowser.org/oma/group/Q3SZQ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DAQ9-1", "protein_name": "Spermatogenesis-associated protein 19, mitochondrial", "gene_name": "Spata19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIITTWIMYIFARKTVGLPFPPRVNSDIEVEESEAVSVVQHWLNKTEEEASRSIREKMSINDSPTHGHDIHVTRDLVKHHLSKSDMLTDPSQEVLEERTRIQFIRWSHTRIFQVPSEVMDDVMQERIDQVRRSVSHLMCDSYNDPSFRTSCSEC", "length": 154 }, "evidence": [ { "id": "Q3SZQ3", "url": "https://omabrowser.org/oma/group/Q3SZQ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "sperm mitochondrion organization", "id": "GO:0030382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030382", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ3", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZQ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZQ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZQ3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 26, 116 ], "sequon_annotation_sites": [ { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZQ6-1", "uniprot_ac": "Q3SZQ6", "uniprot_id": "RL32_BOVIN", "mass": { "chemical_mass": 15874.0, "monoisotopic_mass": 15874.0 }, "refseq": { "ac": "NP_001029955", "name": "large ribosomal subunit protein eL32", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029955" }, "gene_names": [ { "name": "RPL32", "type": "recommended", "evidence": [ { "id": "Q3SZQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ] }, { "name": "RPL32", "type": "synonym", "evidence": [ { "id": "NP_001029955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029955" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL32", "type": "recommended", "evidence": [ { "id": "Q3SZQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L32", "type": "synonym", "evidence": [ { "id": "NP_001029955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029955" }, { "id": "Q3SZQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL32", "type": "synonym", "evidence": [ { "id": "NP_001029955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029955" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6#function" }, { "database": "UniProtKB", "id": "P62910", "url": "https://www.uniprot.org/uniprotkb/P62910#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL32", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6", "locus": { "chromosome": "22", "start_pos": 56348415, "end_pos": 56344651, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015283", "url": "https://www.ensembl.org/id/ENSBTAG00000015283" } ] } } ], "crossref": [ { "id": "Q3SZQ6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015283", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015283", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615556", "url": "https://www.ncbi.nlm.nih.gov/gene/615556", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001515", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001515", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036351", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036351", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615556", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615556", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HPSGYEE", "url": "https://omabrowser.org/oma/group/HPSGYEE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZQ6", "url": "https://www.orthodb.org/?gene=Q3SZQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23413", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23413", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23413:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23413:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01655", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01655", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029955", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRITNPNARLRSEENE", "length": 135, "header": "sp|Q3SZQ6-1|RL32_BOVIN Isoform 1 of Large ribosomal subunit protein eL32 OS=Bos taurus OX=9913 GN=RPL32 PE=2 SV=3 CANONICAL=Q3SZQ6-1" }, "isoforms": [ { "isoform_ac": "Q3SZQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6/entry#Q3SZQ6-1", "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRITNPNARLRSEENE", "length": 135, "header": "sp|Q3SZQ6-1|RL32_BOVIN Isoform 1 of Large ribosomal subunit protein eL32 OS=Bos taurus OX=9913 GN=RPL32 PE=2 SV=3 CANONICAL=Q3SZQ6-1" }, "locus": { "chromosome": "22", "start_pos": 56348365, "end_pos": 56345530, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020323.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020323.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020323.2", "url": "https://www.ensembl.org/id/ENSBTAP00000020323.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 62, "end_pos": 62, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "site_lbl": "Ser62" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615556", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615556", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BVB1-1", "protein_name": "60S ribosomal protein L32", "gene_name": "RPL32", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPTGFRKFLVHNVKELEVLMMSNKSYCAEIAHNVSSKNRKVIVERAAQLAIKITNPNARLRSEENE", "length": 135 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P04359-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "RpL32", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTIRPAYRPKIVKKRTKHFIRHQSDRYAKLSHKWRKPKGIDNRVRRRFKGQYLMPNIGYGSNKRTRHMLPTGFKKFLVHNVRELEVLLMQNRVYCGEIAHGVSSKKRKEIVERAKQLSVRLTNPNGRLRSQENE", "length": 134 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P38061-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "RPL32", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASLPHPKIVKKHTKKFKRHHSDRYHRVAENWRKQKGIDSVVRRRFRGNISQPKIGYGSNKKTKFLSPSGHKTFLVANVKDLETLTMHTKTYAAEIAHNISAKNRVVILARAKALGIKVTNPKGRLALEA", "length": 130 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P49211-1", "protein_name": "Large ribosomal subunit protein eL32z", "gene_name": "RPL32A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVPLLTKKVVKKRSAKFIRPQSDRRITVKESWRRPKGIDSRVRRKFKGVTLMPNVGYGSDKKTRHYLPNGFKKFVVHNTSELELLMMHNRTYCAEIAHNVSTKKRKAIVERASQLDVVVTNRLARLRSQEDE", "length": 133 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P62910-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "RPL32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE", "length": 135 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62911-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "Rpl32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE", "length": 135 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62912-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "Rpl32", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE", "length": 135 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55AB5-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "rpl32", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPSPINRTKIVKKKTTKFNRFQSDLFKRVGASWRKPRGIDNRVRRRFSGSRAMPSIGFGSAKATKDVCPDGFKRFVIRNVQELEVLLMQNRRYAAVIFHGVSAKSRKAIVERAAELNIKVTTPNARLRSEERE", "length": 133 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6QAT0-1", "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "RPL32", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE", "length": 135 }, "evidence": [ { "id": "Q3SZQ6", "url": "https://omabrowser.org/oma/group/Q3SZQ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ6", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZQ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 135, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZQ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZQ6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 62 ], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZR3-1", "uniprot_ac": "Q3SZR3", "uniprot_id": "A1AG_BOVIN", "mass": { "chemical_mass": 23182.0, "monoisotopic_mass": 23182.0 }, "refseq": { "ac": "NP_001035592", "name": "alpha-1-acid glycoprotein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, "gene_names": [ { "name": "ORM1", "type": "recommended", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ] }, { "name": "AGP", "type": "synonym", "evidence": [ { "id": "NP_001035592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ] }, { "name": "ORM1", "type": "synonym", "evidence": [ { "id": "NP_001035592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ] } ], "protein_names": [ { "name": "Alpha-1-acid glycoprotein", "type": "recommended", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3/entry#names_and_taxonomy" } ] }, { "name": "OMD", "type": "synonym", "evidence": [ { "id": "NP_001035592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3/entry#names_and_taxonomy" } ] }, { "name": "Orosomucoid", "type": "synonym", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3/entry#names_and_taxonomy" } ] }, { "name": "alpha-1-acid glycoprotein precursor", "type": "synonym", "evidence": [ { "id": "NP_001035592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ] }, { "name": "alpha-1-acid glycoprotein", "type": "synonym", "evidence": [ { "id": "NP_001035592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ] } ], "function": [ { "annotation": "Alpha1-acid glycoprotein isoforms that can be detected in bovine milk are reported.", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "17692138", "url": "https://glygen.org/publication/PubMed/17692138" } ] }, { "annotation": "As in human AGP and several other lipocalins, a temperature-induced molten globule state has been observed in the denaturation pathway of bovine AGP.", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "24530968", "url": "https://glygen.org/publication/PubMed/24530968" } ] }, { "annotation": "Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#function" } ] }, { "annotation": "Results provide evidence that locally produced alpha-1 acid glycoprotein may be involved in protecting sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "24931131", "url": "https://glygen.org/publication/PubMed/24931131" } ] }, { "annotation": "Studied the regulation and immune function of AGP in cultured bovine oviduct epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "25123565", "url": "https://glygen.org/publication/PubMed/25123565" } ] }, { "annotation": "Study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein and inhibited the chemotaxis of monocytes", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "18577362", "url": "https://glygen.org/publication/PubMed/18577362" } ] }, { "annotation": "The acute phase protein orosomucoid 1 is upregulated in early lactation but does not trigger appetite-suppressing STAT3 signaling via the leptin receptor.", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "32229118", "url": "https://glygen.org/publication/PubMed/32229118" } ] }, { "annotation": "The presence of lipopolysaccharide binding protein (LBP) and alpha1-acid glycoprotein (AGP) was demonstrated in all seven adipose tissue depots. Expression of AGP and LBP suggests that they may have roles as local and systemic inflammatory adipokines.", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" }, { "database": "PubMed", "id": "25542063", "url": "https://glygen.org/publication/PubMed/25542063" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3", "locus": { "chromosome": "8", "start_pos": 103554403, "end_pos": 103550934, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017294", "url": "https://www.ensembl.org/id/ENSBTAG00000017294" } ] } } ], "crossref": [ { "id": "Q3SZR3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19451", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19451", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497200", "url": "https://www.ncbi.nlm.nih.gov/gene/497200", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "16", "url": "https://glyconnect.expasy.org/browser/proteins/16", "database": "GlyConnect", "categories": [ "Glycomics", "Glycoproteomics" ] }, { "id": "1872383", "url": "https://www.iedb.org/epitope/1872383", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:497200", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:497200", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZR3", "url": "https://www.orthodb.org/?gene=Q3SZR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11967", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11967", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11967:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11967:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q3SZR3", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q3SZR3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLWALAVLSHLPLLDAQSPECANLMTVAPITNATMDLLSGKWFYIGSAFRNPEYNKSARAIQAAFFYLEPRHAEDKLITREYQTIEDKCVYNCSFIKIYRQNGTLSKVESDREHFVDLLLSKHFRTFMLAASWNGTKNVGVSFYADKPEVTQEQKKEFLDVIKCIGIQESEIIYTDEKKDACGPLEKQHEEERKKETEAS", "length": 202, "header": "sp|Q3SZR3-1|A1AG_BOVIN Isoform 1 of Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1 CANONICAL=Q3SZR3-1" }, "isoforms": [ { "isoform_ac": "Q3SZR3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3/entry#Q3SZR3-1", "sequence": { "sequence": "MALLWALAVLSHLPLLDAQSPECANLMTVAPITNATMDLLSGKWFYIGSAFRNPEYNKSARAIQAAFFYLEPRHAEDKLITREYQTIEDKCVYNCSFIKIYRQNGTLSKVESDREHFVDLLLSKHFRTFMLAASWNGTKNVGVSFYADKPEVTQEQKKEFLDVIKCIGIQESEIIYTDEKKDACGPLEKQHEEERKKETEAS", "length": 202, "header": "sp|Q3SZR3-1|A1AG_BOVIN Isoform 1 of Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1 CANONICAL=Q3SZR3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G47518TP", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 104, "start_aa": "Asn", "end_pos": 104, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn104", "evidence": [ { "id": "23345538", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23345538" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G56438GL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 104, "start_aa": "Asn", "end_pos": 104, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn104", "evidence": [ { "id": "23345538", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23345538" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 104, "start_aa": "Asn", "end_pos": 104, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn104", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 136, "start_aa": "Asn", "end_pos": 136, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn136", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 34, "start_aa": "Asn", "end_pos": 34, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn34", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#ptm_processing" } ] }, { "glytoucan_ac": "G78182GT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 57, "start_aa": "Asn", "end_pos": 57, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn57", "evidence": [ { "id": "23345538", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23345538" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 57, "start_aa": "Asn", "end_pos": 57, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn57", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 94, "start_aa": "Asn", "end_pos": 94, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn94", "evidence": [ { "id": "Q3SZR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3#ptm_processing" } ] }, { "glytoucan_ac": "G03436RQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G06290IR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G09811YI", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G13269KZ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G14050KB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G15569GG", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G20425TQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G23863VK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G24382MA", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G25965IE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G26495ZQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G28916LJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G29568VE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G29972TM", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G31973KL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G32259BI", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G34381JF", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G34423JR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G37310RN", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G38738YC", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G41940MB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G42512YG", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G43157GC", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G46842SD", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G47012YE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G47518TP", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "Q3SZR3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3SZR3" } ] }, { "glytoucan_ac": "G50045TK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G52527GH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G56491QJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G59536GA", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G68908VL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G70898AL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G73028DK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G73519FS", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G80269JV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G83201DL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G85307IL", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G90202LF", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G90463CM", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G90688JZ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G91438JH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G92793BY", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] }, { "glytoucan_ac": "G99518NJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "evidence": [ { "id": "9740055", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9740055" }, { "id": "16", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Differential expression and secretion of alpha1-acid glycoprotein in bovine milk.", "journal": "The Journal of dairy research", "date": "2007-08", "authors": "Ceciliani Fabrizio, Pocacqua Vanessa, Lecchi Cristina, Fortin Riccardo, Rebucci Raffaella, Avallone Giancarlo, Bronzo Valerio, Cheli Federica, Sartorelli Paola", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "17692138", "url": "https://glygen.org/publication/PubMed/17692138" } ] }, { "title": "Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression.", "journal": "Veterinary research", "date": "2008", "authors": "Lecchi Cristina, Ceciliani Fabrizio, Bernasconi Sergio, Franciosi Federica, Bronzo Valerio, Sartorelli Paola", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "18577362", "url": "https://glygen.org/publication/PubMed/18577362" } ] }, { "title": "Glycoproteomic analysis of the secretome of human endothelial cells.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M", "evidence": [ { "database": "GlyConnect", "id": "16", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ], "reference": [ { "type": "PubMed", "id": "23345538", "url": "https://glygen.org/publication/PubMed/23345538" } ] }, { "title": "Bovine \u03b1\u2081-acid glycoprotein, a thermostable version of its human counterpart: insights from Fourier transform infrared spectroscopy and in silico modelling.", "journal": "Biochimie", "date": "2014-07", "authors": "Baldassarre Maurizio, Galeazzi Roberta, Maggiore Beatrice, Tanfani Fabio, Scir\u00e8 Andrea", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "24530968", "url": "https://glygen.org/publication/PubMed/24530968" } ] }, { "title": "An acute-phase protein as a regulator of sperm survival in the bovine oviduct: alpha 1-acid-glycoprotein impairs neutrophil phagocytosis of sperm in vitro.", "journal": "The Journal of reproduction and development", "date": "2014", "authors": "Liu Jinghui, Marey Mohamed A, Kowsar Rasoul, Hambruch Nina, Shimizu Takashi, Haneda Shingo, Matsui Motozumi, Sasaki Motoki, Hayakawa Hiroyuki, Pfarrer Christiane, Miyamoto Akio", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "24931131", "url": "https://glygen.org/publication/PubMed/24931131" } ] }, { "title": "Evidence for a novel, local acute-phase response in the bovine oviduct: progesterone and lipopolysaccharide up-regulate alpha 1-acid-glycoprotein expression in epithelial cells in vitro.", "journal": "Molecular reproduction and development", "date": "2014-09", "authors": "Kowsar R, Hambruch N, Marey M A, Liu J, Shimizu T, Pfarrer C, Miyamoto A", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "25123565", "url": "https://glygen.org/publication/PubMed/25123565" } ] }, { "title": "Expression of \u03b11-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle.", "journal": "Veterinary journal (London, England : 1997)", "date": "2015-02", "authors": "Rahman Mizanur M, Lecchi Cristina, Sauerwein Helga, Mielenz Manfred, H\u00e4u\u00dfler Susanne, Restelli Laura, Giudice Chiara, Ceciliani Fabrizio", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "25542063", "url": "https://glygen.org/publication/PubMed/25542063" } ] }, { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "1872383", "url": "https://www.iedb.org/epitope/1872383" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] }, { "title": "The acute phase protein orosomucoid 1 is upregulated in early lactation but does not trigger appetite-suppressing STAT3 signaling via the leptin receptor.", "journal": "Journal of dairy science", "date": "2020-05", "authors": "McGuckin M M, Giesy S L, Davis A N, Abyeta M A, Horst E A, Saed Samii S, Zang Y, Butler W R, Baumgard L H, McFadden J W, Boisclair Y R", "evidence": [ { "database": "RefSeq", "id": "NP_001035592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035592" } ], "reference": [ { "type": "PubMed", "id": "32229118", "url": "https://glygen.org/publication/PubMed/32229118" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3SZR3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3SZR3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulphate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein.", "journal": "Electrophoresis", "date": "1998", "authors": "Kuster B, Hunter AP, Wheeler SF, Dwek RA, Harvey DJ", "evidence": [ { "database": "GlyConnect", "id": "16", "url": "https://glyconnect.expasy.org/browser/proteins/16" } ], "reference": [ { "type": "PubMed", "id": "9740055", "url": "https://glygen.org/publication/PubMed/9740055" } ] } ], "pathway": [ { "id": "bta:497200", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:497200", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR3", "url": "https://www.uniprot.org/uniprotkb/Q3SZR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZR3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 202, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZR3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZR3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 34, 57, 94, 104, 136 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 136, "end_pos": 138 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 54 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 47 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_n_linked_sites", "count": 5 }, { "field": "exact_n_linked_glycan_sites", "count": 2 }, { "field": "exact_n_linked_glycans", "count": 3 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 45 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 49 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 47 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "exact_n_linked_glycan_sites", "count": 2 }, { "field": "exact_n_linked_glycans", "count": 3 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 45 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZT1-1", "uniprot_ac": "Q3SZT1", "uniprot_id": "GSG1_BOVIN", "mass": { "chemical_mass": 35634.0, "monoisotopic_mass": 35634.0 }, "refseq": { "ac": "NP_001069401", "name": "germ cell-specific gene 1 protein isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069401" }, "gene_names": [ { "name": "GSG1", "type": "recommended", "evidence": [ { "id": "Q3SZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1" } ] }, { "name": "GSG1", "type": "synonym", "evidence": [ { "id": "NP_001069401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069401" } ] } ], "protein_names": [ { "name": "Germ cell-specific gene 1 protein", "type": "recommended", "evidence": [ { "id": "Q3SZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#names_and_taxonomy" } ] }, { "name": "germ cell-specific gene 1 protein isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001069401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069401" } ] }, { "name": "germ cell-specific gene 1 protein", "type": "synonym", "evidence": [ { "id": "NP_001069401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069401" } ] } ], "function": [ { "annotation": "May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1#function" }, { "database": "UniProtKB", "id": "A0AAA9TKH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH9#function" }, { "database": "UniProtKB", "id": "ARBA00056393", "url": "https://www.uniprot.org/uniprotkb/ARBA00056393#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GSG1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1", "locus": { "chromosome": "5", "start_pos": 96785806, "end_pos": 96766338, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004721", "url": "https://www.ensembl.org/id/ENSBTAG00000004721" } ] } } ], "crossref": [ { "id": "Q3SZT1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZT1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004721", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530502", "url": "https://www.ncbi.nlm.nih.gov/gene/530502", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530502", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530502", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AFYTAWL", "url": "https://omabrowser.org/oma/group/AFYTAWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MED9", "url": "https://www.orthodb.org/?gene=A0A3Q1MED9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZT1", "url": "https://www.orthodb.org/?gene=Q3SZT1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07803", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07803", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069401", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MED9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MED9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MED9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MED9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMY3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT1-2", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTEREILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC", "length": 323, "header": "sp|Q3SZT1-1|GSG1_BOVIN Isoform 1 of Germ cell-specific gene 1 protein OS=Bos taurus OX=9913 GN=GSG1 PE=2 SV=2 CANONICAL=Q3SZT1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MED9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#A0A3Q1MED9-1", "sequence": { "sequence": "MGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGSCLAPSRLISCPPSQREILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC", "length": 324, "header": "tr|A0A3Q1MED9-1|A0A3Q1MED9_BOVIN Computationally mapped isoform of Germ cell associated 1 OS=Bos taurus OX=9913 GN=GSG1 PE=3 SV=1 CANONICAL=Q3SZT1-1" }, "locus": { "chromosome": "5", "start_pos": 96785730, "end_pos": 96778176, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069368.1" } ] } }, { "isoform_ac": "A0AAA9SVA8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#A0AAA9SVA8-1", "sequence": { "sequence": "MVKMGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTERGEKGLLEFATLQGPRHPTLRFGGKRLMEKASLSHPPLGCGKDPLVITGSPVCLHWTTHQFHPATDGLAVHGEPWLQPQAERLCCHLLCLVGPSGDGGPYDVLTGFPGNGQLGSRRLEATRLELWLGFLHGLGLLYLLHGIGGHHLQHLHPAGAGVQVQAQQELPRSPRLPTTSPPVLPAAAGVHSPPGGPRDQLPPVPLSAHPLHLRRGRLLLRTT", "length": 341, "header": "tr|A0AAA9SVA8-1|A0AAA9SVA8_BOVIN Computationally mapped isoform of Germ cell associated 1 OS=Bos taurus OX=9913 GN=GSG1 PE=3 SV=1 CANONICAL=Q3SZT1-1" }, "locus": { "chromosome": "5", "start_pos": 96785657, "end_pos": 96774768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090403.1" } ] } }, { "isoform_ac": "A0AAA9TKH9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#A0AAA9TKH9-1", "sequence": { "sequence": "MSNSSQLIQNVCLTQKMGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTEREILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC", "length": 339, "header": "tr|A0AAA9TKH9-1|A0AAA9TKH9_BOVIN Computationally mapped isoform of Germ cell-specific gene 1 protein OS=Bos taurus OX=9913 GN=GSG1 PE=3 SV=1 CANONICAL=Q3SZT1-1" }, "locus": { "chromosome": "5", "start_pos": 96785730, "end_pos": 96766469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098897.1" } ] } }, { "isoform_ac": "A0AAF6YMY3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#A0AAF6YMY3-1", "sequence": { "sequence": "MSNSSQLIQNVCLTQKMGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTERGEKGLLEFATLQGPRHPTLRFGGKRLMEKASLSHPPLGCGKDPLVITGSPVCLHWTTHQFHPATDGLAVHGEPWLQPQAERLCCHLLCLVGPSGDGGPYDVLTGFPGNGQLGSRRLEATRLELWLGFLHGLGLLYLLHGIGGHHLQHLHPAGAGVQVQAQQELPRSPRLPTTSPPVLPAAAGVHSPPGGPRDQLPPVPLSAHPLHLRRGRLLLRTT", "length": 354, "header": "tr|A0AAF6YMY3-1|A0AAF6YMY3_BOVIN Computationally mapped isoform of Germ cell associated 1 OS=Bos taurus OX=9913 GN=GSG1 PE=3 SV=1 CANONICAL=Q3SZT1-1" }, "locus": { "chromosome": "5", "start_pos": 96785657, "end_pos": 96766469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006198.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006198.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006198.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006198.4" } ] } }, { "isoform_ac": "Q3SZT1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#Q3SZT1-1", "sequence": { "sequence": "MGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTEREILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC", "length": 323, "header": "sp|Q3SZT1-1|GSG1_BOVIN Isoform 1 of Germ cell-specific gene 1 protein OS=Bos taurus OX=9913 GN=GSG1 PE=2 SV=2 CANONICAL=Q3SZT1-1" }, "locus": {} }, { "isoform_ac": "Q3SZT1-2", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1/entry#Q3SZT1-2", "sequence": { "sequence": "MSNSSQLIQNVCLTQKMGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTERGEKGLLEFATLQGPRHPTLRFGGKRLMEKASLSHPPLGLVAKILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC", "length": 380, "header": "sp|Q3SZT1-2|GSG1_BOVIN Isoform 2 of Germ cell-specific gene 1 protein OS=Bos taurus OX=9913 GN=GSG1 PE=2 SV=2 CANONICAL=Q3SZT1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530502", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530502", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2KHT4-1", "protein_name": "Germ cell-specific gene 1 protein", "gene_name": "GSG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKMELSKAFSGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMPVSLDGDTNTSTQEVVQYNWETGDDRFSFRSFRSGMWLSCEETVEEPALLHPQSWKQFRALRSSGTAAAKGERCRSFIELTPPAKREILWLSLGTQITYIGLQFISFLLLLTDLLLTGNPACGLKLSAFAAVSSVLSGLLGMVAHMMYSQVFQATVNLGPEDWRPHVWNYGWAFYMAWLSFTCCMASAVTTFNTYTRMVLEFKCKHSKSFKENPNCLPHHHQCFPRRLSSAAPTVGPLTSYHQYHNQPIHSVSEGVDFYSELRNKGFQRGASQELKEAVRSSVEEEQC", "length": 349 }, "evidence": [ { "id": "Q3SZT1", "url": "https://omabrowser.org/oma/group/Q3SZT1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYL2-1", "protein_name": "Germ cell-specific gene 1 protein", "gene_name": "Gsg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEFQKGPSDQRTFVSAILNMLSLGLSTASLLSSEWFVGAQKVPKPLCGQSLAAKCFDMPMSLDGGITNASAQEVVQYTWEAGDDRFSFLTFRSGMWLSCEETVEEPGEKCRRFIELTPPAQREVLWLSLGAQTAYIGLQFISFLLLLTDLLLTSNPGCGLKLSAFAAVSLVLSGLLGMVAHMLYLQVFQATANLGPEDWRPHSWNYGWAFYTAWVSFTCCMVSAVTTFNTYTRMVLEFKCRHGTSFNTNPSCRAQHHRCFLPPLTCAVHAGEPSTSCHQHPSHPIRSVSESIDLYSAAALQDKKFQQENSQELKEATESSVEEQC", "length": 325 }, "evidence": [ { "id": "Q3SZT1", "url": "https://omabrowser.org/oma/group/Q3SZT1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R1W2-1", "protein_name": "Germ cell-specific gene 1 protein", "gene_name": "Gsg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKMEFQKGSSDQRTFISAILNMLSLGLSTASLLSSEWFVGTQKVPKPLCGQSLAAKCFDMPMSLDGGIANTSAQEVVQYTWETGDDRFSFLAFRSGMWLSCEETMEEPGEKCRRFIELTPPAQRWLSLGAQTAYIGLQLISFLLLLTDLLLTTNPGCGLKLSAFAAVSLVLSGLLGMVAHMLYSQVFQATANLGPEDWRPHSWNYGWAFYTAWVSFTCCMASAVTTFNMYTRMVLEFKCRHSKSFNTNPSCLAQHHRCFLPPPLTCTTHAGEPLSSCHQYPSHPIRSVSEAIDLYSALQDKEFQQGISQELKEVVEPSVEEQR", "length": 324 }, "evidence": [ { "id": "Q3SZT1", "url": "https://omabrowser.org/oma/group/Q3SZT1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZT1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZT1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZT1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZU5-1", "uniprot_ac": "Q3SZU5", "uniprot_id": "SPCS3_BOVIN", "mass": { "chemical_mass": 20313.0, "monoisotopic_mass": 20313.0 }, "refseq": { "ac": "NP_001070461", "name": "signal peptidase complex subunit 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" }, "gene_names": [ { "name": "SPCS3", "type": "recommended", "evidence": [ { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5" } ] }, { "name": "SPC22/23", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] }, { "name": "SPCS3", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] } ], "protein_names": [ { "name": "Signal peptidase complex subunit 3", "type": "recommended", "evidence": [ { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5/entry#names_and_taxonomy" } ] }, { "name": "Microsomal signal peptidase 22/23 kDa subunit", "type": "synonym", "evidence": [ { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5/entry#names_and_taxonomy" } ] }, { "name": "SPC22/23", "type": "synonym", "evidence": [ { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5/entry#names_and_taxonomy" } ] }, { "name": "SPase 22 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] }, { "name": "SPase 22/23 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" }, { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5/entry#names_and_taxonomy" } ] }, { "name": "microsomal signal peptidase 22/23 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] }, { "name": "microsomal signal peptidase 23 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] }, { "name": "signal peptidase complex subunit 3 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] }, { "name": "signal peptidase complex subunit 3", "type": "synonym", "evidence": [ { "id": "NP_001070461", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461" } ] } ], "function": [ { "annotation": "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5#function" }, { "database": "UniProtKB", "id": "P61009", "url": "https://www.uniprot.org/uniprotkb/P61009#function" }, { "database": "UniProtKB", "id": "Q12133", "url": "https://www.uniprot.org/uniprotkb/Q12133#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPCS3", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5", "locus": { "chromosome": "27", "start_pos": 7782843, "end_pos": 7777144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014146", "url": "https://www.ensembl.org/id/ENSBTAG00000014146" } ] } } ], "crossref": [ { "id": "Q3SZU5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014146", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014146", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767917", "url": "https://www.ncbi.nlm.nih.gov/gene/767917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767917", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767917", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWDDGHG", "url": "https://omabrowser.org/oma/group/FWDDGHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZU5", "url": "https://www.orthodb.org/?gene=Q3SZU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12804", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12804", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12804:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12804:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04573", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04573", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-422085", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422085", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9768727", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070461", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZU5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 180, "header": "sp|Q3SZU5-1|SPCS3_BOVIN Isoform 1 of Signal peptidase complex subunit 3 OS=Bos taurus OX=9913 GN=SPCS3 PE=2 SV=1 CANONICAL=Q3SZU5-1" }, "isoforms": [ { "isoform_ac": "Q3SZU5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5/entry#Q3SZU5-1", "sequence": { "sequence": "MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 180, "header": "sp|Q3SZU5-1|SPCS3_BOVIN Isoform 1 of Signal peptidase complex subunit 3 OS=Bos taurus OX=9913 GN=SPCS3 PE=2 SV=1 CANONICAL=Q3SZU5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 141, "start_aa": "Asn", "end_pos": 141, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn141", "evidence": [ { "id": "Q3SZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767917", "resource": "KEGG Pathway" }, { "id": "R-BTA-422085", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422085", "resource": "Reactome", "description": "Synthesis, secretion, and deacylation of Ghrelin" }, { "id": "R-BTA-9768727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "resource": "Reactome", "description": "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "B0G180-1", "protein_name": "Signal peptidase complex subunit 3", "gene_name": "spcs3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MHSLSQRANTIVCFGGIVLVGVLLLNVLSRAFFSDHVDVDIKLNEIHRFNTQRNFEYSFISIDLDANLEPLFNWNTKMLFLYVTAEYRTKQNVLSQVVVWDHILTEKSKANIHEKRLSKYPIINQGLGLKNNTIKLTFNYNVVPISGILTRHQVGTSEFKFPTTYMKEAY", "length": 170 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P28687-1", "protein_name": "Signal peptidase complex subunit 3", "gene_name": "SPCS3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKERSVPVSIAVSRVTLRNVEDFTGPRERSDLAFVTFDITADLQSIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIILRGDNPRLFLKDMKSKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGLLPLVTGSGHMSVPFPDTYETTKSY", "length": 180 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P61009-1", "protein_name": "Signal peptidase complex subunit 3", "gene_name": "SPCS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 180 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q53YF3-1", "protein_name": "Signal peptidase complex subunit 3B", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MHSFGYRANALLTFAVTILAFICAIASFSDNFSNQNPSAQIQILNINWFQKQPHGNDEVSLTLNITADLQSLFTWNTKQVFAFVAAEYETSKNALNQVSLWDAIIPEKEHAKFWIQISNKYRFIDQGHNLRGKDFNLTLHWHVMPKTGKMFADKIVMSGYRLPNAYR", "length": 167 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q6ZWQ7-1", "protein_name": "Signal peptidase complex subunit 3", "gene_name": "Spcs3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 180 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VCA9-1", "protein_name": "Signal peptidase complex subunit 3", "gene_name": "Spase22-23", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHTVLTRGNATVAYTLSVLACLTFSCFLSTVFLDYRTDANINTVRVLVKNVPDYGASREKHDLGFVTFDLQTNLTGIFNWNVKQLFLYLTAEYQTPANQLNQVVLWDKIILRGDNAVLDFKNMNTKYYFWDDGNGLKDNRNVSLYLSWNIIPNAGLLPSVQATGKHLFKFPADYATSSI", "length": 179 }, "evidence": [ { "id": "Q3SZU5", "url": "https://omabrowser.org/oma/group/Q3SZU5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5" } ], "pmid": "" }, { "name": "signal peptide processing", "id": "GO:0006465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006465", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "signal peptidase complex", "id": "GO:0005787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005787", "evidence": [ { "database": "UniProtKB", "id": "Q3SZU5", "url": "https://www.uniprot.org/uniprotkb/Q3SZU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 180, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZU5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 141 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZV2-1", "uniprot_ac": "Q3SZV2", "uniprot_id": "KXDL1_BOVIN", "mass": { "chemical_mass": 19635.0, "monoisotopic_mass": 19635.0 }, "refseq": { "ac": "NP_001029777", "name": "kxDL motif-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" }, "gene_names": [ { "name": "KXD1", "type": "recommended", "evidence": [ { "id": "Q3SZV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ] }, { "name": "C19orf50", "type": "synonym", "evidence": [ { "id": "NP_001029777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" } ] }, { "name": "C7H19orf50", "type": "synonym", "evidence": [ { "id": "NP_001029777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" } ] }, { "name": "KXD1", "type": "synonym", "evidence": [ { "id": "NP_001029777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" } ] } ], "protein_names": [ { "name": "KxDL motif-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3SZV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2/entry#names_and_taxonomy" } ] }, { "name": "UPF0459 protein C19orf50 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" } ] }, { "name": "kxDL motif-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777" } ] } ], "function": [ { "annotation": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2#function" }, { "database": "UniProtKB", "id": "Q9BQD3", "url": "https://www.uniprot.org/uniprotkb/Q9BQD3#function" }, { "database": "UniProtKB", "id": "Q80XH1", "url": "https://www.uniprot.org/uniprotkb/Q80XH1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KXD1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2", "locus": { "chromosome": "7", "start_pos": 4607363, "end_pos": 4614956, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010545", "url": "https://www.ensembl.org/id/ENSBTAG00000010545" } ] } } ], "crossref": [ { "id": "Q3SZV2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "534253", "url": "https://www.ncbi.nlm.nih.gov/gene/534253", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534253", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534253", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZV2", "url": "https://www.orthodb.org/?gene=Q3SZV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13511", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13511", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13511:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13511:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029777", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZV2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPPDSASRVFSSRILSMVNADDVSAIILAQKNMLDRFEKTNEMLLNFNNLSSARLQQMNERFLHHTRTLVEMKRDLDSIFRRIRTLKGKLARQHPEAFSHIPEASLLEDEDEDPIPPSTTTTIATSEQSTGSCDTSPDTVSPSLSPGFEDLSHIRPGSPAINGRSHTDDEEMPGE", "length": 176, "header": "sp|Q3SZV2-1|KXDL1_BOVIN Isoform 1 of KxDL motif-containing protein 1 OS=Bos taurus OX=9913 GN=KXD1 PE=2 SV=1 CANONICAL=Q3SZV2-1" }, "isoforms": [ { "isoform_ac": "Q3SZV2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2/entry#Q3SZV2-1", "sequence": { "sequence": "MDPPDSASRVFSSRILSMVNADDVSAIILAQKNMLDRFEKTNEMLLNFNNLSSARLQQMNERFLHHTRTLVEMKRDLDSIFRRIRTLKGKLARQHPEAFSHIPEASLLEDEDEDPIPPSTTTTIATSEQSTGSCDTSPDTVSPSLSPGFEDLSHIRPGSPAINGRSHTDDEEMPGE", "length": 176, "header": "sp|Q3SZV2-1|KXDL1_BOVIN Isoform 1 of KxDL motif-containing protein 1 OS=Bos taurus OX=9913 GN=KXD1 PE=2 SV=1 CANONICAL=Q3SZV2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534253", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534253", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV2", "url": "https://www.uniprot.org/uniprotkb/Q3SZV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZV2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZV6-1", "uniprot_ac": "Q3SZV6", "uniprot_id": "TIM21_BOVIN", "mass": { "chemical_mass": 27938.0, "monoisotopic_mass": 27938.0 }, "refseq": { "ac": "NP_001030530", "name": "mitochondrial import inner membrane translocase subunit Tim21 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" }, "gene_names": [ { "name": "TIMM21", "type": "recommended", "evidence": [ { "id": "Q3SZV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ] }, { "name": "C17H18orf55", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] }, { "name": "C24H18orf55", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] }, { "name": "TIM21", "type": "synonym", "evidence": [ { "id": "Q3SZV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ] }, { "name": "TIMM21", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim21", "type": "recommended", "evidence": [ { "id": "Q3SZV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6/entry#names_and_taxonomy" } ] }, { "name": "TIM21-like protein, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" }, { "id": "Q3SZV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial TIM21-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim21 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim21", "type": "synonym", "evidence": [ { "id": "NP_001030530", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530" } ] } ], "function": [ { "annotation": "Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6#function" }, { "database": "UniProtKB", "id": "Q9BVV7", "url": "https://www.uniprot.org/uniprotkb/Q9BVV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM21", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6", "locus": { "chromosome": "24", "start_pos": 4237445, "end_pos": 4243534, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009687", "url": "https://www.ensembl.org/id/ENSBTAG00000009687" } ] } } ], "crossref": [ { "id": "Q3SZV6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "614633", "url": "https://www.ncbi.nlm.nih.gov/gene/614633", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038552", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038552", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614633", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614633", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZV6", "url": "https://www.orthodb.org/?gene=Q3SZV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13032", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13032", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13032:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13032:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030530", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZV6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MICTLLRAVRCTERLHGCPGKPWFLPHSVPHRACSQTEPRWRWGLQEQNTTARPRCIWGVTQRSIWTQVRSPQSAKEDGSKQVSVHRSQGGETVLSTSQKVKEAGRDFTYLIVVLIGISITGGLFYTIFRELFSSSSPNKIYGKALEKCRSHPEVISVFGEPVKGYGEVTRRGRRQLVSFIEYKKDGLKHMRVKFYIQGSEPGKQGTVHLEVKENPESGEYEFRYIFVELEPYSRTIVVEDNRS", "length": 244, "header": "sp|Q3SZV6-1|TIM21_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim21 OS=Bos taurus OX=9913 GN=TIMM21 PE=2 SV=1 CANONICAL=Q3SZV6-1" }, "isoforms": [ { "isoform_ac": "Q3SZV6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6/entry#Q3SZV6-1", "sequence": { "sequence": "MICTLLRAVRCTERLHGCPGKPWFLPHSVPHRACSQTEPRWRWGLQEQNTTARPRCIWGVTQRSIWTQVRSPQSAKEDGSKQVSVHRSQGGETVLSTSQKVKEAGRDFTYLIVVLIGISITGGLFYTIFRELFSSSSPNKIYGKALEKCRSHPEVISVFGEPVKGYGEVTRRGRRQLVSFIEYKKDGLKHMRVKFYIQGSEPGKQGTVHLEVKENPESGEYEFRYIFVELEPYSRTIVVEDNRS", "length": 244, "header": "sp|Q3SZV6-1|TIM21_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim21 OS=Bos taurus OX=9913 GN=TIMM21 PE=2 SV=1 CANONICAL=Q3SZV6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614633", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614633", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TIM23 mitochondrial import inner membrane translocase complex", "id": "GO:0005744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005744", "evidence": [ { "database": "UniProtKB", "id": "Q3SZV6", "url": "https://www.uniprot.org/uniprotkb/Q3SZV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 244, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZV6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 242, "end_pos": 244 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZX2-1", "uniprot_ac": "Q3SZX2", "uniprot_id": "IPP2_BOVIN", "mass": { "chemical_mass": 22982.0, "monoisotopic_mass": 22982.0 }, "refseq": { "ac": "NP_001030469", "name": "protein phosphatase inhibitor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030469" }, "gene_names": [ { "name": "PPP1R2", "type": "recommended", "evidence": [ { "id": "Q3SZX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ] }, { "name": "PPP1R2", "type": "synonym", "evidence": [ { "id": "NP_001030469", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030469" } ] } ], "protein_names": [ { "name": "Protein phosphatase inhibitor 2", "type": "recommended", "evidence": [ { "id": "Q3SZX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2/entry#names_and_taxonomy" } ] }, { "name": "IPP-2", "type": "synonym", "evidence": [ { "id": "NP_001030469", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030469" }, { "id": "Q3SZX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase inhibitor 2", "type": "synonym", "evidence": [ { "id": "NP_001030469", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030469" } ] } ], "function": [ { "annotation": "Inhibitor of protein-phosphatase 1.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2", "locus": { "chromosome": "1", "start_pos": 72138818, "end_pos": 72100127, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006724", "url": "https://www.ensembl.org/id/ENSBTAG00000006724" } ] } } ], "crossref": [ { "id": "Q3SZX2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "532726", "url": "https://www.ncbi.nlm.nih.gov/gene/532726", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532726", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532726", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZX2", "url": "https://www.orthodb.org/?gene=Q3SZX2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12398:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12398:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030469", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZX2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASTASHRPIKGILKNKSSTTSSVVSTAEQPGKSVDEELSKKSQKWDEMSILATYHPADKDYGLMKIDEPSTPYHSMVADDEDALSDSETTEALTPDILARKLTAAAAESLEPKYRVREQESSGDEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLNDEEEDEEMSETAAGESMNMEESSQGSATSDQLQNKSQSS", "length": 207, "header": "sp|Q3SZX2-1|IPP2_BOVIN Isoform 1 of Protein phosphatase inhibitor 2 OS=Bos taurus OX=9913 GN=PPP1R2 PE=2 SV=1 CANONICAL=Q3SZX2-1" }, "isoforms": [ { "isoform_ac": "Q3SZX2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2/entry#Q3SZX2-1", "sequence": { "sequence": "MAASTASHRPIKGILKNKSSTTSSVVSTAEQPGKSVDEELSKKSQKWDEMSILATYHPADKDYGLMKIDEPSTPYHSMVADDEDALSDSETTEALTPDILARKLTAAAAESLEPKYRVREQESSGDEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLNDEEEDEEMSETAAGESMNMEESSQGSATSDQLQNKSQSS", "length": 207, "header": "sp|Q3SZX2-1|IPP2_BOVIN Isoform 1 of Protein phosphatase inhibitor 2 OS=Bos taurus OX=9913 GN=PPP1R2 PE=2 SV=1 CANONICAL=Q3SZX2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser123" }, { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser124" }, { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser129" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser132" }, { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by ATM", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser44" }, { "start_pos": 73, "end_pos": 73, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by GSK3", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Thr73" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser87" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Ser89" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Thr92" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "site_lbl": "Thr96" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532726", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532726", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "pmid": "" }, { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase inhibitor activity", "id": "GO:0004864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004864", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX2", "url": "https://www.uniprot.org/uniprotkb/Q3SZX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZX2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 207, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZX2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZX2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 44, 73, 87, 89, 92, 96, 123, 124, 129, 132 ], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 202, "end_pos": 204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZY8-1", "uniprot_ac": "Q3SZY8", "uniprot_id": "SMAKA_BOVIN", "mass": { "chemical_mass": 10969.0, "monoisotopic_mass": 10969.0 }, "refseq": {}, "gene_names": [ { "name": "AKAP19", "type": "recommended", "evidence": [ { "id": "Q3SZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ] } ], "protein_names": [ { "name": "A-kinase anchoring protein 19", "type": "recommended", "evidence": [ { "id": "Q3SZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8/entry#names_and_taxonomy" } ] }, { "name": "Small membrane A-kinase anchor protein", "type": "synonym", "evidence": [ { "id": "Q3SZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8/entry#names_and_taxonomy" } ] }, { "name": "Small membrane AKAP", "type": "synonym", "evidence": [ { "id": "Q3SZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8/entry#names_and_taxonomy" } ] }, { "name": "smAKAP", "type": "synonym", "evidence": [ { "id": "Q3SZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to type I regulatory subunits of protein kinase A (PKA-RI) and anchors/targets them to the plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8#function" }, { "database": "UniProtKB", "id": "Q9BSF0", "url": "https://www.uniprot.org/uniprotkb/Q9BSF0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKAP19", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8", "locus": {} } ], "crossref": [ { "id": "Q3SZY8", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767914", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767914", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QTFPFPN", "url": "https://omabrowser.org/oma/group/QTFPFPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZY8", "url": "https://www.orthodb.org/?gene=Q3SZY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36471", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36471", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36471:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36471:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15127", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15127", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCMKSKQTFPFPTTLESEKRHVSEENFMPEEKFLPRIPSLVNVKEEVKEPPGPQIVVFEFAQHLSQEILSDALQQWAGNNLKYYDIPYIESEGP", "length": 95, "header": "sp|Q3SZY8-1|SMAKA_BOVIN Isoform 1 of A-kinase anchoring protein 19 OS=Bos taurus OX=9913 GN=AKAP19 PE=3 SV=1 CANONICAL=Q3SZY8-1" }, "isoforms": [ { "isoform_ac": "Q3SZY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8/entry#Q3SZY8-1", "sequence": { "sequence": "MGCMKSKQTFPFPTTLESEKRHVSEENFMPEEKFLPRIPSLVNVKEEVKEPPGPQIVVFEFAQHLSQEILSDALQQWAGNNLKYYDIPYIESEGP", "length": 95, "header": "sp|Q3SZY8-1|SMAKA_BOVIN Isoform 1 of A-kinase anchoring protein 19 OS=Bos taurus OX=9913 GN=AKAP19 PE=3 SV=1 CANONICAL=Q3SZY8-1" }, "locus": { "chromosome": "2", "start_pos": 6101048, "end_pos": 6100764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038641.4", "url": "https://www.ensembl.org/id/ENSBTAT00000038641.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038453.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038453.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "site_lbl": "Ser40" }, { "start_pos": 66, "end_pos": 66, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "site_lbl": "Ser66" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "site_lbl": "Ser92" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767914", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767914", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PFG0-1", "protein_name": "A-kinase anchoring protein 19", "gene_name": "C2orf88", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGCIKSKDAFAGSNAIRVEGSREGDEGCTGEKSSLIAGMADEKGPSSAIVLDYAHRLSHEILDQAVKQWAVTESKYSDIPFIESDVP", "length": 87 }, "evidence": [ { "id": "Q3SZY8", "url": "https://omabrowser.org/oma/group/Q3SZY8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287ABE0-1", "protein_name": "A-kinase anchoring protein 19", "gene_name": "C2orf88", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGCMKSKQTFPFSTTIESEKRPASQESFMPEERFLPRIPSLVNIKEEVKEPPGPEIVVSEFAHRLSQEILTDALQQWAGNNIKYYDIPYIESDGP", "length": 95 }, "evidence": [ { "id": "Q3SZY8", "url": "https://omabrowser.org/oma/group/Q3SZY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0C8S0-1", "protein_name": "A-kinase anchoring protein 19", "gene_name": "akap19", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGCMKSKRRDPTQNSDSSEKVDGKPGKHGEKAVLVFSEIGSMEDSVRINPVLLDYAQRLSEEIVARAVQQWAEVDSRYSDIPYIECDVP", "length": 89 }, "evidence": [ { "id": "Q3SZY8", "url": "https://omabrowser.org/oma/group/Q3SZY8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BSF0-1", "protein_name": "A-kinase anchoring protein 19", "gene_name": "AKAP19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNVKEEVKEPPGTNTVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP", "length": 95 }, "evidence": [ { "id": "Q3SZY8", "url": "https://omabrowser.org/oma/group/Q3SZY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase A regulatory subunit binding", "id": "GO:0034237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034237", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY8", "url": "https://www.uniprot.org/uniprotkb/Q3SZY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 95, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZY8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 40, 66, 92 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T016-1", "uniprot_ac": "Q3T016", "uniprot_id": "TSACC_BOVIN", "mass": { "chemical_mass": 13729.0, "monoisotopic_mass": 13729.0 }, "refseq": {}, "gene_names": [ { "name": "TSACC", "type": "recommended", "evidence": [ { "id": "Q3T016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T016" } ] } ], "protein_names": [ { "name": "TSSK6-activating co-chaperone protein", "type": "recommended", "evidence": [ { "id": "Q3T016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T016/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Co-chaperone that facilitates HSP-mediated activation of TSSK6.", "evidence": [ { "database": "UniProtKB", "id": "Q3T016", "url": "https://www.uniprot.org/uniprotkb/Q3T016#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T016", "url": "https://www.uniprot.org/uniprotkb/Q3T016" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSACC", "url": "https://www.uniprot.org/uniprotkb/Q3T016", "locus": { "chromosome": "3", "start_pos": 14479559, "end_pos": 14486476, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055910", "url": "https://www.ensembl.org/id/ENSBTAG00000055910" } ] } } ], "crossref": [ { "id": "Q3T016", "url": "https://alphafold.ebi.ac.uk/entry/Q3T016", "database": "AlphaFoldDB", "categories": [] }, { "id": "767912", "url": "https://www.ncbi.nlm.nih.gov/gene/767912", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767912", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767912", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T016", "url": "https://www.orthodb.org/?gene=Q3T016", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37368", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37368", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37368:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37368:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q3T016", "url": "https://www.uniprot.org/uniprotkb/Q3T016", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T016-1", "url": "https://www.uniprot.org/uniprotkb/Q3T016-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQLPSHPTNRRAKEEGNAVPLCRAKPSPSFINLQASSPPVTLLKILPTKLPSGINHKPKECLGLLECMYANLQLQTQLAQQQMAILENLQASKTQLAPGKENKNSSLPALSRNLLLSHLPQFSK", "length": 125, "header": "sp|Q3T016-1|TSACC_BOVIN Isoform 1 of TSSK6-activating co-chaperone protein OS=Bos taurus OX=9913 GN=TSACC PE=2 SV=1 CANONICAL=Q3T016-1" }, "isoforms": [ { "isoform_ac": "Q3T016-1", "url": "https://www.uniprot.org/uniprotkb/Q3T016/entry#Q3T016-1", "sequence": { "sequence": "MEQLPSHPTNRRAKEEGNAVPLCRAKPSPSFINLQASSPPVTLLKILPTKLPSGINHKPKECLGLLECMYANLQLQTQLAQQQMAILENLQASKTQLAPGKENKNSSLPALSRNLLLSHLPQFSK", "length": 125, "header": "sp|Q3T016-1|TSACC_BOVIN Isoform 1 of TSSK6-activating co-chaperone protein OS=Bos taurus OX=9913 GN=TSACC PE=2 SV=1 CANONICAL=Q3T016-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767912", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767912", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T016", "url": "https://www.uniprot.org/uniprotkb/Q3T016" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q3T016", "url": "https://www.uniprot.org/uniprotkb/Q3T016" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T016-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T016-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T016" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T021-1", "uniprot_ac": "Q3T021", "uniprot_id": "SPAT9_BOVIN", "mass": { "chemical_mass": 28676.0, "monoisotopic_mass": 28676.0 }, "refseq": { "ac": "NP_001029908", "name": "spermatogenesis-associated protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029908" }, "gene_names": [ { "name": "SPATA9", "type": "recommended", "evidence": [ { "id": "Q3T021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T021" } ] }, { "name": "SPATA9", "type": "synonym", "evidence": [ { "id": "NP_001029908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029908" } ] } ], "protein_names": [ { "name": "Spermatogenesis-associated protein 9", "type": "recommended", "evidence": [ { "id": "Q3T021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T021/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 9", "type": "synonym", "evidence": [ { "id": "NP_001029908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029908" } ] } ], "function": [ { "annotation": "May play at role in testicular development/spermatogenesis and may be an important factor in male infertility.", "evidence": [ { "database": "UniProtKB", "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA9", "url": "https://www.uniprot.org/uniprotkb/Q3T021", "locus": { "chromosome": "7", "start_pos": 94976501, "end_pos": 95003346, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007231", "url": "https://www.ensembl.org/id/ENSBTAG00000007231" } ] } } ], "crossref": [ { "id": "Q3T021", "url": "https://alphafold.ebi.ac.uk/entry/Q3T021", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007231", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007231", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613406", "url": "https://www.ncbi.nlm.nih.gov/gene/613406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613406", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613406", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LSEPMFP", "url": "https://omabrowser.org/oma/group/LSEPMFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T021", "url": "https://www.orthodb.org/?gene=Q3T021", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35669", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35669", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35669:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35669:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15824", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15824", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T021-1", "url": "https://www.uniprot.org/uniprotkb/Q3T021-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPIKPVGWICGQVLKNFSGRIEGIQKVIMDLIDEFKDEFPTILRLSQSNQKREPMQKPSKIRMAIALAKINRGTLIQGLNSISRSSKSVAKLLQPQLACRLLELRAISHRLLKEVNAPRQPLYNIQVRKGSLFEIISFPAKTALTSIMCASYAALIYLTVCVNAVLEKIMKIFQEEESIRQNREESENFRNAFSEPVLSEPLFPEGEIKAKPYRSLPEKPDSISDRPKLPANKLSNKIQVLHSVFDQSAEMNE", "length": 253, "header": "sp|Q3T021-1|SPAT9_BOVIN Isoform 1 of Spermatogenesis-associated protein 9 OS=Bos taurus OX=9913 GN=SPATA9 PE=2 SV=1 CANONICAL=Q3T021-1" }, "isoforms": [ { "isoform_ac": "Q3T021-1", "url": "https://www.uniprot.org/uniprotkb/Q3T021/entry#Q3T021-1", "sequence": { "sequence": "MPIKPVGWICGQVLKNFSGRIEGIQKVIMDLIDEFKDEFPTILRLSQSNQKREPMQKPSKIRMAIALAKINRGTLIQGLNSISRSSKSVAKLLQPQLACRLLELRAISHRLLKEVNAPRQPLYNIQVRKGSLFEIISFPAKTALTSIMCASYAALIYLTVCVNAVLEKIMKIFQEEESIRQNREESENFRNAFSEPVLSEPLFPEGEIKAKPYRSLPEKPDSISDRPKLPANKLSNKIQVLHSVFDQSAEMNE", "length": 253, "header": "sp|Q3T021-1|SPAT9_BOVIN Isoform 1 of Spermatogenesis-associated protein 9 OS=Bos taurus OX=9913 GN=SPATA9 PE=2 SV=1 CANONICAL=Q3T021-1" }, "locus": { "chromosome": "7", "start_pos": 95003243, "end_pos": 94976687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009510.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009510.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009510.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009510.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613406", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613406", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MH48-1", "protein_name": "Spermatogenesis-associated protein 9", "gene_name": "Spata9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVRPIGWICGQVLKNFSGRLEGIQKAMMDLLDEFKDELPGILRLSKSKQKKDPVKKTSKIRMALAVAQINRGTLIQGLNSISSSSKSVAKLLQPQLACRLLELRHISHRLLREVNAPSQPLYSMQVRKGSLLDIISFPAKTALTSIIYASYAALIYLAVCVNAVLAKIKNIFQEEESIRQNRESENFRKAFSEPVLPEPMFSEGEIKAKPYRSLPEKPDNLSEHPKPPANKQSNKIQVLHSVFDQSAEVNQ", "length": 252 }, "evidence": [ { "id": "Q3T021", "url": "https://omabrowser.org/oma/group/Q3T021/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9BWV2-1", "protein_name": "Spermatogenesis-associated protein 9", "gene_name": "SPATA9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPIKPVGWICGQVLKNFSGRIEGIQKAIMDLVDEFKDEFPTILRLSQSNQKREPAQKTSKIRMAIALAKINRATLIRGLNSISRSSKSVAKLLHPQLACRLLELRDISGRLLREVNAPRQPLYNIQVRKGSLFEIISFPAKTALTSIIYASYAALIYLAVCVNAVLKKVKNIFQEEESIRQNREESENCRKAFSEPVLSEPMFAEGEIKAKPYRSLPEKPDISDYPKLLANKQSNNIQVLHSVFDQSAEMNEQI", "length": 254 }, "evidence": [ { "id": "Q3T021", "url": "https://omabrowser.org/oma/group/Q3T021/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9R3-1", "protein_name": "Spermatogenesis-associated protein 9", "gene_name": "Spata9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVRPIGWICGQVVKNFSGRLEGLQKAIMDLIDEFKDDLPTILRLSQSSQKTDPVQKTSKVRMALALAKINRGTLIQGLNHISSSSKSVAKLLQPRLAYRLLELRSISHRLLREVNVASQPLHSVQMKRGSLFEIISFPAKTALTSIMYASYAALIYLAVCVNAVLAKIKKIFQEEESIRQNRESENFRKAFSEPALRKPMFSESEIKAKPYRSLPEKPDNLLDQPKPPANKQSNKIQVLHSVFDQLAELNE", "length": 252 }, "evidence": [ { "id": "Q3T021", "url": "https://omabrowser.org/oma/group/Q3T021/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T021", "url": "https://www.uniprot.org/uniprotkb/Q3T021" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T021-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 253, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T021-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T021" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T024-1", "uniprot_ac": "Q3T024", "uniprot_id": "ROP1L_BOVIN", "mass": { "chemical_mass": 24426.0, "monoisotopic_mass": 24426.0 }, "refseq": { "ac": "NP_001069185", "name": "ropporin-1-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069185" }, "gene_names": [ { "name": "ROPN1L", "type": "recommended", "evidence": [ { "id": "Q3T024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ] }, { "name": "ROPN1L", "type": "synonym", "evidence": [ { "id": "NP_001069185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069185" } ] } ], "protein_names": [ { "name": "Ropporin-1-like protein", "type": "recommended", "evidence": [ { "id": "Q3T024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T024/entry#names_and_taxonomy" } ] }, { "name": "ropporin 1-like", "type": "synonym", "evidence": [ { "id": "NP_001069185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069185" } ] }, { "name": "ropporin-1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001069185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069185" } ] } ], "function": [ { "annotation": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024#function" }, { "database": "UniProtKB", "id": "Q9EQ00", "url": "https://www.uniprot.org/uniprotkb/Q9EQ00#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ROPN1L", "url": "https://www.uniprot.org/uniprotkb/Q3T024", "locus": { "chromosome": "20", "start_pos": 62795147, "end_pos": 62814323, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003539", "url": "https://www.ensembl.org/id/ENSBTAG00000003539" } ] } } ], "crossref": [ { "id": "Q3T024", "url": "https://alphafold.ebi.ac.uk/entry/Q3T024", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23019", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23019", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515565", "url": "https://www.ncbi.nlm.nih.gov/gene/515565", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "Q3T024", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T024*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR047844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515565", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515565", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T024", "url": "https://www.orthodb.org/?gene=Q3T024", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "NP_001069185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T024-1", "url": "https://www.uniprot.org/uniprotkb/Q3T024-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLPDTMFCAQQIHIPPELTDILKQFTKAAIRTQPADVLQWSAGYFSALSRGDPLPVKDRIEMPMATQKTDTGLTQGLLKVLHKQCSHKEYVDLADLEQKWKNLCLPVEKFRALLQLDPCEDKIEWIKFLALGCSMLGGSLNTAMKHLCEILTTDPEGGPARIPFGTFSYVYRYLSGLDSDIPESDTEAYLSSLKENAAARKNGMIGLSDFFVLKRKI", "length": 218, "header": "sp|Q3T024-1|ROP1L_BOVIN Isoform 1 of Ropporin-1-like protein OS=Bos taurus OX=9913 GN=ROPN1L PE=1 SV=1 CANONICAL=Q3T024-1" }, "isoforms": [ { "isoform_ac": "Q3T024-1", "url": "https://www.uniprot.org/uniprotkb/Q3T024/entry#Q3T024-1", "sequence": { "sequence": "MPLPDTMFCAQQIHIPPELTDILKQFTKAAIRTQPADVLQWSAGYFSALSRGDPLPVKDRIEMPMATQKTDTGLTQGLLKVLHKQCSHKEYVDLADLEQKWKNLCLPVEKFRALLQLDPCEDKIEWIKFLALGCSMLGGSLNTAMKHLCEILTTDPEGGPARIPFGTFSYVYRYLSGLDSDIPESDTEAYLSSLKENAAARKNGMIGLSDFFVLKRKI", "length": 218, "header": "sp|Q3T024-1|ROP1L_BOVIN Isoform 1 of Ropporin-1-like protein OS=Bos taurus OX=9913 GN=ROPN1L PE=1 SV=1 CANONICAL=Q3T024-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515565", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515565", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "radial spoke", "id": "GO:0001534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001534", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "Q3T024", "url": "https://www.uniprot.org/uniprotkb/Q3T024" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T024-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T024-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T024" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T026-1", "uniprot_ac": "Q3T026", "uniprot_id": "GTSFL_BOVIN", "mass": { "chemical_mass": 19115.0, "monoisotopic_mass": 19115.0 }, "refseq": { "ac": "NP_001073069", "name": "gametocyte-specific factor 1-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073069" }, "gene_names": [ { "name": "GTSF1L", "type": "recommended", "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" } ] }, { "name": "FAM112A", "type": "synonym", "evidence": [ { "id": "NP_001073069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073069" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" } ] }, { "name": "GTSF1L", "type": "synonym", "evidence": [ { "id": "NP_001073069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073069" } ] } ], "protein_names": [ { "name": "Gametocyte-specific factor 1-like", "type": "recommended", "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM112A", "type": "synonym", "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026/entry#names_and_taxonomy" } ] }, { "name": "gametocyte-specific factor 1-like", "type": "synonym", "evidence": [ { "id": "NP_001073069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073069" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T026", "url": "https://www.uniprot.org/uniprotkb/Q3T026" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTSF1L", "url": "https://www.uniprot.org/uniprotkb/Q3T026", "locus": { "chromosome": "13", "start_pos": 72276287, "end_pos": 72277184, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011233", "url": "https://www.ensembl.org/id/ENSBTAG00000011233" } ] } } ], "crossref": [ { "id": "Q3T026", "url": "https://alphafold.ebi.ac.uk/entry/Q3T026", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011233", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011233", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524670", "url": "https://www.ncbi.nlm.nih.gov/gene/524670", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524670", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524670", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DDPQQTF", "url": "https://omabrowser.org/oma/group/DDPQQTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T026", "url": "https://www.orthodb.org/?gene=Q3T026", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073069", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T026", "url": "https://www.uniprot.org/uniprotkb/Q3T026", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T026-1", "url": "https://www.uniprot.org/uniprotkb/Q3T026-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPEALETCPYNPHHRIPLSRFQYHLASCRRKNPKKAKKMASCKYNACHVVPIKKLEEHEAACVNKSTMEEEDSLSPLKVSLPNAGQKGNRNASPVSPRLPNPDLWNVDSTNCHPMFVLKSFIPQKLVCESDTRESETDDHNPIPDCPRRRSSDRESEPPAEDTSLLKA", "length": 169, "header": "sp|Q3T026-1|GTSFL_BOVIN Isoform 1 of Gametocyte-specific factor 1-like OS=Bos taurus OX=9913 GN=GTSF1L PE=2 SV=1 CANONICAL=Q3T026-1" }, "isoforms": [ { "isoform_ac": "Q3T026-1", "url": "https://www.uniprot.org/uniprotkb/Q3T026/entry#Q3T026-1", "sequence": { "sequence": "MEPEALETCPYNPHHRIPLSRFQYHLASCRRKNPKKAKKMASCKYNACHVVPIKKLEEHEAACVNKSTMEEEDSLSPLKVSLPNAGQKGNRNASPVSPRLPNPDLWNVDSTNCHPMFVLKSFIPQKLVCESDTRESETDDHNPIPDCPRRRSSDRESEPPAEDTSLLKA", "length": 169, "header": "sp|Q3T026-1|GTSFL_BOVIN Isoform 1 of Gametocyte-specific factor 1-like OS=Bos taurus OX=9913 GN=GTSF1L PE=2 SV=1 CANONICAL=Q3T026-1" }, "locus": { "chromosome": "13", "start_pos": 72276840, "end_pos": 72276334, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014919.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014919.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014919.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014919.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524670", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524670", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HCY2-1", "protein_name": "Gametocyte-specific factor 1-like", "gene_name": "Gtsf1l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPESIEICPYNPHHRIPLSRFQYHLASCRKKNPKKAKKMASCKYNACHVVPIRKLAEHEATCVNRSSMEEEDTLSPLHVSLPQPQNEDTLQVRWLSNPDTWNVDSANCHPMFVLKSFVPQKLVCESDTQESQRDQPLEDPQSRTRRANL", "length": 150 }, "evidence": [ { "id": "Q3T026", "url": "https://omabrowser.org/oma/group/Q3T026/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6A438-1", "protein_name": "Gametocyte specific factor 1-like", "gene_name": "Gtsf1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPESIEICPYNPHHRIPLSRFQYHLASCRKKNPKKAKKMASCKYNACHVVPIRKLAEHEATCVNRSSMEEEDALGPLQVSLPRPQNEDTLQVRWLSSPDIWNVDGANCHPMFVLKSFVPQKLVCESDIQESPGGDQCPEDPQTRTRKANF", "length": 151 }, "evidence": [ { "id": "Q3T026", "url": "https://omabrowser.org/oma/group/Q3T026/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CWD0-1", "protein_name": "Gametocyte-specific factor 1-like", "gene_name": "Gtsf1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPESIEICPYNPHHRIPLSRFQYHLASCRKKNPKKAKKMASCKYNACHVVPIRKLAEHEATCVNRSSVEEEDTLGPLQVSLPQPQNQDTLQVRWLSNPDIWNVDGANCHPMFVLKSFVPQKLVCESDIQESRGGDQCPEDPQTRTRKANF", "length": 151 }, "evidence": [ { "id": "Q3T026", "url": "https://omabrowser.org/oma/group/Q3T026/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H1H1-1", "protein_name": "Gametocyte-specific factor 1-like", "gene_name": "GTSF1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPEAFEICPYDPHHRIPLSRFQYHLASCRRKNPKKAKKMATCKYNACHVVPIKNLEEHEAVCVNRSAVEEEDTENPLKVSPPSSEQNDDTQQVSPCLPSPDIWNVDGANCQHVFVLKTFFPQKVVCENDTKESARETSPQKILRPGQ", "length": 148 }, "evidence": [ { "id": "Q3T026", "url": "https://omabrowser.org/oma/group/Q3T026/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3T026", "url": "https://www.uniprot.org/uniprotkb/Q3T026" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q3T026", "url": "https://www.uniprot.org/uniprotkb/Q3T026" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T026-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 169, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T026-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T026" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 15, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 15, "end_pos": 15, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 25, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 25, "end_pos": 25, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 29, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 29, "end_pos": 29, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 43, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 43, "end_pos": 43, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 49, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 49, "end_pos": 49, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 59, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 59, "end_pos": 59, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 63, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 63, "end_pos": 63, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026#function" }, { "id": "Q3T026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T026" }, { "id": "PRU01141", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01141" } ], "binding_site_uniprot": 9, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 9, "end_pos": 9, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 65, "end_pos": 67 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T044-1", "uniprot_ac": "Q3T044", "uniprot_id": "P33MX_BOVIN", "mass": { "chemical_mass": 32987.0, "monoisotopic_mass": 32987.0 }, "refseq": { "ac": "NP_001029497", "name": "putative monooxygenase p33MONOX", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029497" }, "gene_names": [ { "name": "P33MONOX", "type": "recommended", "evidence": [ { "id": "Q3T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ] }, { "name": "KIAA1191", "type": "synonym", "evidence": [ { "id": "NP_001029497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029497" } ] }, { "name": "P33MONOX", "type": "synonym", "evidence": [ { "id": "NP_001029497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029497" } ] } ], "protein_names": [ { "name": "Putative monooxygenase p33MONOX", "type": "recommended", "evidence": [ { "id": "Q3T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T044/entry#names_and_taxonomy" } ] }, { "name": "1.-.-.-", "type": "synonym", "evidence": [ { "id": "Q3T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T044/entry#names_and_taxonomy" } ] }, { "name": "putative monooxygenase p33MONOX", "type": "synonym", "evidence": [ { "id": "NP_001029497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029497" } ] } ], "function": [ { "annotation": "Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P33MONOX", "url": "https://www.uniprot.org/uniprotkb/Q3T044", "locus": {} } ], "crossref": [ { "id": "Q3T044", "url": "https://alphafold.ebi.ac.uk/entry/Q3T044", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011608", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011608", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508617", "url": "https://www.ncbi.nlm.nih.gov/gene/508617", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508617", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508617", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TIQAYKG", "url": "https://omabrowser.org/oma/group/TIQAYKG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T044", "url": "https://www.orthodb.org/?gene=Q3T044", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28342:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28342:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029497", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T044-1", "url": "https://www.uniprot.org/uniprotkb/Q3T044-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRQPEVPALEPSGPLGKMSLPIGMYRRAFSYDDALEDPTPMTPPPSDMGSIPWKPVIPERKYQDLAKVEEGEPSVSPPAPAPPPATDSAEKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 305, "header": "sp|Q3T044-1|P33MX_BOVIN Isoform 1 of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=P33MONOX PE=2 SV=1 CANONICAL=Q3T044-1" }, "isoforms": [ { "isoform_ac": "Q3T044-1", "url": "https://www.uniprot.org/uniprotkb/Q3T044/entry#Q3T044-1", "sequence": { "sequence": "MASRQPEVPALEPSGPLGKMSLPIGMYRRAFSYDDALEDPTPMTPPPSDMGSIPWKPVIPERKYQDLAKVEEGEPSVSPPAPAPPPATDSAEKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 305, "header": "sp|Q3T044-1|P33MX_BOVIN Isoform 1 of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=P33MONOX PE=2 SV=1 CANONICAL=Q3T044-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 175, "start_aa": "Thr", "end_pos": 175, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 44, "start_aa": "Thr", "end_pos": 44, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr44", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 175, "end_pos": 175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "site_lbl": "Thr175" }, { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "site_lbl": "Ser183" }, { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "site_lbl": "Thr44" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508617", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508617", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IAV1-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "Kiaa1191", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASRQPEVPALAPSGPLGKMSLPIGMCRRAFSYDDALEDPAPMTPPPSDMGSIPWKPVIPERKYQHLDKTEEGAASVSSLAVTPATATDSSDKTPVVKAKATHVIMNSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETTREEKPPASAQSTPSSTPHSSPKQKSRGWFPSGSSTALPGPNPHTMDSGSGNDKNSADKWSLFGARPLQRSDSGFAVQAYKGAPKPSPMELMRAQATRGGEDPATFKPPKIDVPVVEGKKPPPRTHNLKPRDLNVLTPTGF", "length": 303 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1SLI1-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "KIAA1191", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASRQPEVPALEPSGPLGKMSLPIGMYRRAFSYDDALEDPAPMTPPPSDMGSIPWKPVIPERKYQHLAKVEEGDASASSPAVPLPPATDSADKVPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETNYLRVAEALHKLKLQSGEITREEKQPASTQSTPSSSPHSSPKQKSRGWFTSGSSIALPGPNLSAMDSGSGDKDRSSADKWGLFAPRSLQKSDSGSFATQVYRGAQKPSPMELIRVQATRMAEDPATFQPPKMDIPVIEGKKQLPRTHNLKPRDLNVLTPTGF", "length": 305 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YQF9-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "KIAA1191", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSARQPDAPALEQRGGALPGRMSLPLGVPRRAFSYDDALEDTAPMTPPPADLCANVLWKQPVIPERKYQELAKIEEGDANMNAPVITPSSSTESVNKVPVVKAKATHIIMNSLITKQTQESIQCFEQQAGLRDAGYTPHKGLTAEETKYHRVAEAVHKLKMQSGEMTKDDKQTSSAQSTPSSTPHSSPKHKNRGWFSQGSSASITAPDFVAMEAGGDRLPSERWSFFGPKAIQKSTNDPGGFTIQSYKGAQKPSPMELMRAQATRMTEDPVTFKPPKMDIPVTEGRKQSSHSHNIKPRDLNVLTPTGF", "length": 308 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A4QNZ7-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "p33monox", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVSRPGDLPALEAGPGSSEGLLGGMSIPAGMTRRALSYDDNLERPMSPPPSDINISNLWKRPVIPERKFARLAEEDESEGGVKQSASFESTKPIPVVKAKASSVMNSLIIKQTQESMQKFEKQAGLTDTGYTPHKGLNAEETRYHRLAESMHKLQMQSTDAKEERQPSSNQSTPAGTPQSSPKQKRRGWFNSQGSTASLTGSEMSTSSSSSVDLASAEGPIERWGVFGPRPQVSKSTTDPGTHPDTSGGFALQSYKGAQKPTPMEVMKAQATRLAEDPTNFKAPPKMEIPTMDGKRQVTRPHKLKHRDMNVLTPSGF", "length": 317 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5U2R6-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "P33monox", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASRQPEVPPALAPSGPLSKMSLPIGMCRRAFSYDDALEDPAPMTPPPSDMGSIPWKPVIPERKYQHLDKTEEGAASVSSLAVTPSTATDSSDKAPVVKAKATHIIMNSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETTREEKHPASAQSSPSSTPHSSPKQKSRGWFPSGSSTALPAPNPHSMDPGGGNDRNSADKWSLFGPRPLQKSDSGFAIQAYKGAPKPSPMEVMRAQATRAGEDPAVFKPPKMDVPVVEGKKQPPRTHNLKPRDLNVLTPTGF", "length": 304 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96A73-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "KIAA1191", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRQPEVPALEASAPLGKMSLPIGIYRRAVSYDDTLEDPAPMTPPPSDMGSVPWKPVIPERKYQHLAKVEEGEASLPSPAMTLSSAIDSVDKVPVVKAKATHVIMNSLITKQTQESIQHFERQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGEVTKEERQPASAQSTPSTTPHSSPKQRPRGWFTSGSSTALPGPNPSTMDSGSGDKDRNLSDKWSLFGPRSLQKYDSGSFATQAYRGAQKPSPLELIRAQANRMAEDPAALKPPKMDIPVMEGKKQPPRAHNLKPRDLNVLTPTGF", "length": 305 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DBN4-1", "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "P33monox", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASRQPEVPALAPSGPLGKMSLPIGMCRRAFSYDDALEDPAPMTPPPSDMGSIPWKPVIPERKYQHLDKTEEGAASVSSLAVTPSPATDSSDKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAKEEKHPASAQSTPSSTPHASPKQKSRGWFPSGSSTALPAPNPHTMDPGSGNDRNSADKWSLFGPRPLQKSDSGFAIQAYKGAPRPSPMEVMRAQATRVGEDPATFKPPKMDVPMVEGKKQPLRTHNLKPRDLNVLTPTGF", "length": 303 }, "evidence": [ { "id": "Q3T044", "url": "https://omabrowser.org/oma/group/Q3T044/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q3T044", "url": "https://www.uniprot.org/uniprotkb/Q3T044" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T044-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 305, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T044-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T044" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 44, 175 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 44, 175, 183 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T051-1", "uniprot_ac": "Q3T051", "uniprot_id": "RL39_BOVIN", "mass": { "chemical_mass": 6407.0, "monoisotopic_mass": 6407.0 }, "refseq": { "ac": "NP_001098925", "name": "large ribosomal subunit protein eL39", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098925" }, "gene_names": [ { "name": "RPL39", "type": "recommended", "evidence": [ { "id": "Q3T051", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ] }, { "name": "RPL39", "type": "synonym", "evidence": [ { "id": "NP_001098925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098925" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL39", "type": "recommended", "evidence": [ { "id": "Q3T051", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T051/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L39", "type": "synonym", "evidence": [ { "id": "NP_001098925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098925" }, { "id": "Q3T051", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T051/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL39", "type": "synonym", "evidence": [ { "id": "NP_001098925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098925" } ] } ], "function": [ { "annotation": "RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051#function" }, { "database": "UniProtKB", "id": "P62891", "url": "https://www.uniprot.org/uniprotkb/P62891#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL39", "url": "https://www.uniprot.org/uniprotkb/Q3T051", "locus": { "chromosome": "6", "start_pos": 7252558, "end_pos": 7252850, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034844", "url": "https://www.ensembl.org/id/ENSBTAG00000034844" } ] } } ], "crossref": [ { "id": "Q3T051", "url": "https://alphafold.ebi.ac.uk/entry/Q3T051", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034844", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034844", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767908", "url": "https://www.ncbi.nlm.nih.gov/gene/767908", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101902490", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902490", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:101907518", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907518", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:767908", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767908", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRTKMNI", "url": "https://omabrowser.org/oma/group/RRTKMNI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T051", "url": "https://www.orthodb.org/?gene=Q3T051", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19970", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19970", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19970:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19970:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19970:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19970:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF7A3K8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A3K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3K8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T051-1", "url": "https://www.uniprot.org/uniprotkb/Q3T051-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51, "header": "sp|Q3T051-1|RL39_BOVIN Isoform 1 of Large ribosomal subunit protein eL39 OS=Bos taurus OX=9913 GN=RPL39 PE=3 SV=3 CANONICAL=Q3T051-1" }, "isoforms": [ { "isoform_ac": "A0AAF7A3K8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T051/entry#A0AAF7A3K8-1", "sequence": { "sequence": "QAPEEPSYGTEAKQIPFRTNKRVGTSVSHGLTGAWAERNRQRALVGAQRDLPKPRPRRRLLNTSFRSLPPLFSSPPSYVRLSSFLTMSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 137, "header": "tr|A0AAF7A3K8-1|A0AAF7A3K8_BOVIN Computationally mapped isoform of 60S ribosomal protein L39 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3T051-1" }, "locus": { "chromosome": "X", "start_pos": 4153888, "end_pos": 4150703, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086638.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086638.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062104.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062104.2" } ] } }, { "isoform_ac": "Q3T051-1", "url": "https://www.uniprot.org/uniprotkb/Q3T051/entry#Q3T051-1", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51, "header": "sp|Q3T051-1|RL39_BOVIN Isoform 1 of Large ribosomal subunit protein eL39 OS=Bos taurus OX=9913 GN=RPL39 PE=3 SV=3 CANONICAL=Q3T051-1" }, "locus": { "chromosome": "14", "start_pos": 24496927, "end_pos": 24496775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000064702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054413.1", "url": "https://www.ensembl.org/id/ENSBTAP00000054413.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101902490", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902490", "resource": "KEGG Pathway" }, { "id": "bta:101907518", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907518", "resource": "KEGG Pathway" }, { "id": "bta:767908", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767908", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LLY2-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "LOC100767204", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIWMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LXJ2-1", "protein_name": "60S ribosomal protein L39-like", "gene_name": "LOC100765211", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSHKTCRIKGFLAKKQKQNRPIPQWIQMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2MRW9-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "Rpl39", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "C7G051-1", "protein_name": "60S ribosomal protein L39", "gene_name": "rpl39", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPSNKTLKIKKILGKKQKQNRPVPQWIRLRTDNTIRYNNKRRHWRRTKLGI", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O16130-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RpL39", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAHKSFRIKQKLAKKLKQNRSVPQWVRLRTGNTIRYNAKRRHWRRTKLKL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P04650-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAAQKSFRIKQKMAKAKKQNRPLPQWIRLRTNNTIRYNAKRRNWRRTKMNI", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P51424-1", "protein_name": "Large ribosomal subunit protein eL39z/eL39x", "gene_name": "RPL39C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPSHKSFMIKKKLGKKMRQNRPIPHWIRLRTDNTIRYNAKRRHWRRTKLGF", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P62891-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62892-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "Rpl39", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62893-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "Rpl39", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" }, { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" }, { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" }, { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" }, { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8L8W6-1", "protein_name": "Large ribosomal subunit protein eL39y", "gene_name": "RPL39B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPSHKSFMIKKKLGKKMRQNRPIPNWIRLRTDNKIRYNAKRRHWRRTKLGF", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q98TF5-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSHKTFKIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9CQD0-1", "protein_name": "Large ribosomal subunit protein eL39-like", "gene_name": "Rpl39l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASHKTFRIKRFLAKKQKQNRPIPQWIQMKTGNKIMYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "Q3T051", "url": "https://omabrowser.org/oma/group/Q3T051/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3T051", "url": "https://www.uniprot.org/uniprotkb/Q3T051" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T051-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 51, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T051-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T051" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T056-1", "uniprot_ac": "Q3T056", "uniprot_id": "LDH6B_BOVIN", "mass": { "chemical_mass": 41592.0, "monoisotopic_mass": 41592.0 }, "refseq": { "ac": "NP_001030352", "name": "L-lactate dehydrogenase A-like 6B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030352" }, "gene_names": [ { "name": "LDHAL6B", "type": "recommended", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ] }, { "name": "LDHAL6B", "type": "synonym", "evidence": [ { "id": "NP_001030352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030352" } ] } ], "protein_names": [ { "name": "L-lactate dehydrogenase A-like 6B", "type": "recommended", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.27", "type": "synonym", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056/entry#names_and_taxonomy" } ] }, { "name": "L-lactate dehydrogenase A-like 6B", "type": "synonym", "evidence": [ { "id": "NP_001030352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030352" } ] } ], "function": [ { "annotation": "Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme.", "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056#function" }, { "database": "UniProtKB", "id": "Q6ZMR3", "url": "https://www.uniprot.org/uniprotkb/Q6ZMR3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LDHAL6B", "url": "https://www.uniprot.org/uniprotkb/Q3T056", "locus": {} } ], "crossref": [ { "id": "Q3T056", "url": "https://alphafold.ebi.ac.uk/entry/Q3T056", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509519", "url": "https://www.ncbi.nlm.nih.gov/gene/509519", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T056", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T056*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509519", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509519", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T056", "url": "https://www.orthodb.org/?gene=Q3T056", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43128:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43128:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02866", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02866", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030352", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23444", "url": "https://www.rhea-db.org/rhea/23444", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T056-1", "url": "https://www.uniprot.org/uniprotkb/Q3T056-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWTVGILRASQRAGTVRANFLCLGMAPSPCPPAATPLGGAWAVAPASKMATVKCELMKNFTSEEPVRNSKISIVGTGSVGMACAVSILLKGLSDELALVDVDEGRLKGETMDLQHGSLFVKMPNIVSSRDYVVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMMSSIVQYSPRCKLIVVSNPVDILTYVAWKLSAFPQNRVIGSGCNLDTARFRFLIGQRLSIHSESCHGWILGEHGDSSVPVWSGVNIAGVPLKELNLDIGTDKDPEQWKNVHKDVVASAYEIIKMKGYTYWAIGLSVADLTESILKNLRRVHPVSTRIKGLYGINEEVFLSVPCILGESGITDLIKVKLAPEEEARLQKSAKTLWDIQKELKF", "length": 381, "header": "sp|Q3T056-1|LDH6B_BOVIN Isoform 1 of L-lactate dehydrogenase A-like 6B OS=Bos taurus OX=9913 GN=LDHAL6B PE=2 SV=1 CANONICAL=Q3T056-1" }, "isoforms": [ { "isoform_ac": "Q3T056-1", "url": "https://www.uniprot.org/uniprotkb/Q3T056/entry#Q3T056-1", "sequence": { "sequence": "MSWTVGILRASQRAGTVRANFLCLGMAPSPCPPAATPLGGAWAVAPASKMATVKCELMKNFTSEEPVRNSKISIVGTGSVGMACAVSILLKGLSDELALVDVDEGRLKGETMDLQHGSLFVKMPNIVSSRDYVVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMMSSIVQYSPRCKLIVVSNPVDILTYVAWKLSAFPQNRVIGSGCNLDTARFRFLIGQRLSIHSESCHGWILGEHGDSSVPVWSGVNIAGVPLKELNLDIGTDKDPEQWKNVHKDVVASAYEIIKMKGYTYWAIGLSVADLTESILKNLRRVHPVSTRIKGLYGINEEVFLSVPCILGESGITDLIKVKLAPEEEARLQKSAKTLWDIQKELKF", "length": 381, "header": "sp|Q3T056-1|LDH6B_BOVIN Isoform 1 of L-lactate dehydrogenase A-like 6B OS=Bos taurus OX=9913 GN=LDHAL6B PE=2 SV=1 CANONICAL=Q3T056-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509519", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509519", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-lactate dehydrogenase (NAD+) activity", "id": "GO:0004459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004459", "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lactate metabolic process", "id": "GO:0006089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006089", "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ], "pmid": "" }, { "name": "pyruvate catabolic process", "id": "GO:0042867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042867", "evidence": [ { "database": "UniProtKB", "id": "Q3T056", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23444", "name": "", "equation": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BNS9-1", "Q3T056-1", "A0AAA9SB13-1", "P19858-1", "A0A3Q1LY19-1", "Q5E9B1-1", "A0A3Q1M4R3-1" ], "evidence": [ { "id": "23444", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23444" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LY19", "gene_name": "", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LY19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY19" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1LY19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY19" } ] } ] }, { "uniprot_ac": "A0A3Q1M4R3", "gene_name": "", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0A3Q1M4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4R3" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1M4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4R3" } ] } ] }, { "uniprot_ac": "A0AAA9SB13", "gene_name": "LDHA", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0AAA9SB13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB13" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0AAA9SB13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB13" } ] } ] }, { "uniprot_ac": "E1BNS9", "gene_name": "LDHC", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "E1BNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS9" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "E1BNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS9" } ] } ] }, { "uniprot_ac": "P19858", "gene_name": "LDHA", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "P19858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19858" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "P19858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19858" } ] } ] }, { "uniprot_ac": "Q3T056", "gene_name": "LDHAL6B", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ] } ] }, { "uniprot_ac": "Q5E9B1", "gene_name": "LDHB", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T056-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T056-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T056" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.27", "ec_name": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "1.1.1.27", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27" }, { "id": "1.1.1.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.27" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T067-1", "uniprot_ac": "Q3T067", "uniprot_id": "SCPDL_BOVIN", "mass": { "chemical_mass": 47320.0, "monoisotopic_mass": 47320.0 }, "refseq": { "ac": "NP_001029460", "name": "saccharopine dehydrogenase-like oxidoreductase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029460" }, "gene_names": [ { "name": "SCCPDH", "type": "recommended", "evidence": [ { "id": "Q3T067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ] }, { "name": "SCCPDH", "type": "synonym", "evidence": [ { "id": "NP_001029460", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029460" } ] } ], "protein_names": [ { "name": "Saccharopine dehydrogenase-like oxidoreductase", "type": "recommended", "evidence": [ { "id": "Q3T067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T067/entry#names_and_taxonomy" } ] }, { "name": "1.-.-.-", "type": "synonym", "evidence": [ { "id": "Q3T067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T067/entry#names_and_taxonomy" } ] }, { "name": "probable saccharopine dehydrogenase", "type": "synonym", "evidence": [ { "id": "NP_001029460", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029460" } ] }, { "name": "saccharopine dehydrogenase-like oxidoreductase", "type": "synonym", "evidence": [ { "id": "NP_001029460", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029460" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCCPDH", "url": "https://www.uniprot.org/uniprotkb/Q3T067", "locus": { "chromosome": "16", "start_pos": 30588376, "end_pos": 30617983, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003804", "url": "https://www.ensembl.org/id/ENSBTAG00000003804" } ] } } ], "crossref": [ { "id": "Q3T067", "url": "https://alphafold.ebi.ac.uk/entry/Q3T067", "database": "AlphaFoldDB", "categories": [] }, { "id": "507289", "url": "https://www.ncbi.nlm.nih.gov/gene/507289", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507289", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507289", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T067", "url": "https://www.orthodb.org/?gene=Q3T067", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12286", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12286", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12286:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12286:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029460", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T067-1", "url": "https://www.uniprot.org/uniprotkb/Q3T067-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATQQRPFHLVVFGASGFTGQFVTEEVAREQVSPERTSHLPWAVAGRSREKLLRVLERAAMKLGRPTLSSEVGIIICDITNPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGTSCIDISGEPQFLELMYWKYHEKAAEKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTISSGPEGLCVHDGTWKSAVYGFGDKSNLKKLRNESDMKPVPIVGPKLKRRWPISYCRELNSYSIPFLGADVSVVKRTQRYLHENLEQSPVQYAAYINVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFTWLFSFGYFSKQGPTQKQIDASSFTMTFFGQGFSQGVSPVKNKPNIRICTQVKGPEAGYVSTSIAMVQAAMILLNDASDLPKAGGVFTPGAAFSRTKLIDRLNEHGIEFSVISSTEV", "length": 429, "header": "sp|Q3T067-1|SCPDL_BOVIN Isoform 1 of Saccharopine dehydrogenase-like oxidoreductase OS=Bos taurus OX=9913 GN=SCCPDH PE=2 SV=1 CANONICAL=Q3T067-1" }, "isoforms": [ { "isoform_ac": "Q3T067-1", "url": "https://www.uniprot.org/uniprotkb/Q3T067/entry#Q3T067-1", "sequence": { "sequence": "MATQQRPFHLVVFGASGFTGQFVTEEVAREQVSPERTSHLPWAVAGRSREKLLRVLERAAMKLGRPTLSSEVGIIICDITNPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGTSCIDISGEPQFLELMYWKYHEKAAEKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTISSGPEGLCVHDGTWKSAVYGFGDKSNLKKLRNESDMKPVPIVGPKLKRRWPISYCRELNSYSIPFLGADVSVVKRTQRYLHENLEQSPVQYAAYINVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFTWLFSFGYFSKQGPTQKQIDASSFTMTFFGQGFSQGVSPVKNKPNIRICTQVKGPEAGYVSTSIAMVQAAMILLNDASDLPKAGGVFTPGAAFSRTKLIDRLNEHGIEFSVISSTEV", "length": 429, "header": "sp|Q3T067-1|SCPDL_BOVIN Isoform 1 of Saccharopine dehydrogenase-like oxidoreductase OS=Bos taurus OX=9913 GN=SCCPDH PE=2 SV=1 CANONICAL=Q3T067-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "site_lbl": "Ser217" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507289", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507289", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycolipid biosynthetic process", "id": "GO:0009247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009247", "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q3T067", "url": "https://www.uniprot.org/uniprotkb/Q3T067" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T067-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 429, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T067-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T067" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 217 ], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 215, "end_pos": 217 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T071-1", "uniprot_ac": "Q3T071", "uniprot_id": "TMA16_BOVIN", "mass": { "chemical_mass": 23645.0, "monoisotopic_mass": 23645.0 }, "refseq": { "ac": "NP_001030206", "name": "translation machinery-associated protein 16", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206" }, "gene_names": [ { "name": "TMA16", "type": "recommended", "evidence": [ { "id": "Q3T071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T071" } ] }, { "name": "C6H4orf43", "type": "synonym", "evidence": [ { "id": "NP_001030206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206" } ] }, { "name": "TMA16", "type": "synonym", "evidence": [ { "id": "NP_001030206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206" } ] } ], "protein_names": [ { "name": "Translation machinery-associated protein 16", "type": "recommended", "evidence": [ { "id": "Q3T071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T071/entry#names_and_taxonomy" } ] }, { "name": "UPF0534 protein C4orf43 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206" } ] }, { "name": "translation machinery-associated protein 16", "type": "synonym", "evidence": [ { "id": "NP_001030206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206" } ] } ], "function": [ { "annotation": "Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.", "evidence": [ { "database": "UniProtKB", "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071#function" }, { "database": "UniProtKB", "id": "Q96EY4", "url": "https://www.uniprot.org/uniprotkb/Q96EY4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMA16", "url": "https://www.uniprot.org/uniprotkb/Q3T071", "locus": { "chromosome": "6", "start_pos": 2111636, "end_pos": 2141851, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012658", "url": "https://www.ensembl.org/id/ENSBTAG00000012658" } ] } } ], "crossref": [ { "id": "Q3T071", "url": "https://alphafold.ebi.ac.uk/entry/Q3T071", "database": "AlphaFoldDB", "categories": [] }, { "id": "506277", "url": "https://www.ncbi.nlm.nih.gov/gene/506277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506277", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T071", "url": "https://www.orthodb.org/?gene=Q3T071", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13349", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13349", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13349:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13349:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030206", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T071-1", "url": "https://www.uniprot.org/uniprotkb/Q3T071-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKAPKGKSVGQEKKVIHPYSRKAAQITRKAHKQEKKEELKNEKALRLNLIGEKLQWFQNHLDPKKVGYSKRDACELIERYLNRFSSELEQIELRNSFKDRQGRRHCSREAAIRQTLEREQRQYQAHGLEIPDILNADNLKTFREWDFDLKKLPNIKMRKVCASDAVPKKCKKKAVTTIDGDLGELELKDESSDTDEEMTAVA", "length": 203, "header": "sp|Q3T071-1|TMA16_BOVIN Isoform 1 of Translation machinery-associated protein 16 OS=Bos taurus OX=9913 GN=TMA16 PE=2 SV=1 CANONICAL=Q3T071-1" }, "isoforms": [ { "isoform_ac": "Q3T071-1", "url": "https://www.uniprot.org/uniprotkb/Q3T071/entry#Q3T071-1", "sequence": { "sequence": "MPKAPKGKSVGQEKKVIHPYSRKAAQITRKAHKQEKKEELKNEKALRLNLIGEKLQWFQNHLDPKKVGYSKRDACELIERYLNRFSSELEQIELRNSFKDRQGRRHCSREAAIRQTLEREQRQYQAHGLEIPDILNADNLKTFREWDFDLKKLPNIKMRKVCASDAVPKKCKKKAVTTIDGDLGELELKDESSDTDEEMTAVA", "length": 203, "header": "sp|Q3T071-1|TMA16_BOVIN Isoform 1 of Translation machinery-associated protein 16 OS=Bos taurus OX=9913 GN=TMA16 PE=2 SV=1 CANONICAL=Q3T071-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506277", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "preribosome binding", "id": "GO:1990275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990275", "evidence": [ { "database": "UniProtKB", "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q3T071", "url": "https://www.uniprot.org/uniprotkb/Q3T071" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T071-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 203, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T071-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T071" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T073-1", "uniprot_ac": "Q3T073", "uniprot_id": "SERP2_BOVIN", "mass": { "chemical_mass": 7431.0, "monoisotopic_mass": 7431.0 }, "refseq": { "ac": "NP_001107193", "name": "stress-associated endoplasmic reticulum protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193" }, "gene_names": [ { "name": "SERP2", "type": "recommended", "evidence": [ { "id": "Q3T073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T073" } ] }, { "name": "RAMP4-2", "type": "synonym", "evidence": [ { "id": "NP_001107193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193" } ] }, { "name": "SERP2", "type": "synonym", "evidence": [ { "id": "NP_001107193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193" } ] } ], "protein_names": [ { "name": "Stress-associated endoplasmic reticulum protein 2", "type": "recommended", "evidence": [ { "id": "Q3T073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T073/entry#names_and_taxonomy" } ] }, { "name": "Ribosome-associated membrane protein RAMP4-2", "type": "synonym", "evidence": [ { "id": "Q3T073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T073/entry#names_and_taxonomy" } ] }, { "name": "ribosome-associated membrane protein RAMP4-2", "type": "synonym", "evidence": [ { "id": "NP_001107193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193" } ] }, { "name": "stress-associated endoplasmic reticulum protein 2", "type": "synonym", "evidence": [ { "id": "NP_001107193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193" } ] } ], "function": [ { "annotation": "Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073#function" }, { "database": "UniProtKB", "id": "Q9R2C1", "url": "https://www.uniprot.org/uniprotkb/Q9R2C1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERP2", "url": "https://www.uniprot.org/uniprotkb/Q3T073", "locus": { "chromosome": "12", "start_pos": 14645488, "end_pos": 14619809, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051524", "url": "https://www.ensembl.org/id/ENSBTAG00000051524" } ] } } ], "crossref": [ { "id": "Q3T073", "url": "https://alphafold.ebi.ac.uk/entry/Q3T073", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051524", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051524", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613627", "url": "https://www.ncbi.nlm.nih.gov/gene/613627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010580", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010580", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613627", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ATKFITQ", "url": "https://omabrowser.org/oma/group/ATKFITQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T073", "url": "https://www.orthodb.org/?gene=Q3T073", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15601:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15601:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06624", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06624", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001107193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107193", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T073-1", "url": "https://www.uniprot.org/uniprotkb/Q3T073-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM", "length": 65, "header": "sp|Q3T073-1|SERP2_BOVIN Isoform 1 of Stress-associated endoplasmic reticulum protein 2 OS=Bos taurus OX=9913 GN=SERP2 PE=3 SV=1 CANONICAL=Q3T073-1" }, "isoforms": [ { "isoform_ac": "Q3T073-1", "url": "https://www.uniprot.org/uniprotkb/Q3T073/entry#Q3T073-1", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM", "length": 65, "header": "sp|Q3T073-1|SERP2_BOVIN Isoform 1 of Stress-associated endoplasmic reticulum protein 2 OS=Bos taurus OX=9913 GN=SERP2 PE=3 SV=1 CANONICAL=Q3T073-1" }, "locus": { "chromosome": "12", "start_pos": 14645072, "end_pos": 14620412, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107158.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613627", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613627", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKH4-1", "protein_name": "Stress-associated endoplasmic reticulum protein", "gene_name": "SERP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM", "length": 65 }, "evidence": [ { "id": "Q3T073", "url": "https://omabrowser.org/oma/group/Q3T073/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B0V1G1-1", "protein_name": "Stress-associated endoplasmic reticulum protein", "gene_name": "serp2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM", "length": 65 }, "evidence": [ { "id": "Q3T073", "url": "https://omabrowser.org/oma/group/Q3T073/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6TAW2-1", "protein_name": "Stress-associated endoplasmic reticulum protein 2", "gene_name": "Serp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM", "length": 65 }, "evidence": [ { "id": "Q3T073", "url": "https://omabrowser.org/oma/group/Q3T073/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "Q3T073", "url": "https://www.uniprot.org/uniprotkb/Q3T073" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T073-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 65, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T073-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T073" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T083-1", "uniprot_ac": "Q3T083", "uniprot_id": "SDF2L_BOVIN", "mass": { "chemical_mass": 23557.0, "monoisotopic_mass": 23557.0 }, "refseq": { "ac": "NP_001030400", "name": "stromal cell-derived factor 2-like protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400" }, "gene_names": [ { "name": "SDF2L1", "type": "recommended", "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083" } ] }, { "name": "SDF2L1", "type": "synonym", "evidence": [ { "id": "NP_001030400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400" } ] } ], "protein_names": [ { "name": "Stromal cell-derived factor 2-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083/entry#names_and_taxonomy" } ] }, { "name": "SDF2-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400" }, { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083/entry#names_and_taxonomy" } ] }, { "name": "stromal cell-derived factor 2-like protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400" } ] }, { "name": "stromal cell-derived factor 2-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T083", "url": "https://www.uniprot.org/uniprotkb/Q3T083" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDF2L1", "url": "https://www.uniprot.org/uniprotkb/Q3T083", "locus": { "chromosome": "17", "start_pos": 72112698, "end_pos": 72114897, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000067", "url": "https://www.ensembl.org/id/ENSBTAG00000000067" } ] } } ], "crossref": [ { "id": "Q3T083", "url": "https://alphafold.ebi.ac.uk/entry/Q3T083", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000067", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000067", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517962", "url": "https://www.ncbi.nlm.nih.gov/gene/517962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KPQHGTR", "url": "https://omabrowser.org/oma/group/KPQHGTR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T083", "url": "https://www.orthodb.org/?gene=Q3T083", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030400", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T083", "url": "https://www.uniprot.org/uniprotkb/Q3T083", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T083-1", "url": "https://www.uniprot.org/uniprotkb/Q3T083-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSAGSGRAAGPALLGILLALSLSGGRAAKSDAGLVTCGSVLKLFNTQHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGTEGECPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLTNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMASASAHNKWKAMEGIFIKPSPEAPGGHDEL", "length": 221, "header": "sp|Q3T083-1|SDF2L_BOVIN Isoform 1 of Stromal cell-derived factor 2-like protein 1 OS=Bos taurus OX=9913 GN=SDF2L1 PE=2 SV=1 CANONICAL=Q3T083-1" }, "isoforms": [ { "isoform_ac": "Q3T083-1", "url": "https://www.uniprot.org/uniprotkb/Q3T083/entry#Q3T083-1", "sequence": { "sequence": "MWSAGSGRAAGPALLGILLALSLSGGRAAKSDAGLVTCGSVLKLFNTQHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGTEGECPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLTNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMASASAHNKWKAMEGIFIKPSPEAPGGHDEL", "length": 221, "header": "sp|Q3T083-1|SDF2L_BOVIN Isoform 1 of Stromal cell-derived factor 2-like protein 1 OS=Bos taurus OX=9913 GN=SDF2L1 PE=2 SV=1 CANONICAL=Q3T083-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517962", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2BIR7-1", "protein_name": "Stromal cell-derived factor 2-like protein 1 precursor", "gene_name": "sdf2l1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMGPLRVMSVFLDLILVCLVFSPCGARDVDSSYVTCGSLVKLMNTRHSVRLHSHDVKYGSGSGQQSVTGVDSADDANSYWRIRGKPGSICQRGAPIRCGQAIRITHMTTGRNLHSHHFSSPLSNHQEVSAFGENGEGDDLDVWNVQCSATYWDREDAVRFKHTGTEVFLSVTGEQYGHPIRGQREVHGMPSPNQHNYWKVMEGVFIQPSSDPIHHDEL", "length": 218 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D4A9Y0-1", "protein_name": "Stromal cell-derived factor 2-like 1", "gene_name": "Sdf2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGASRGLAGLTLLGLLLALSVRSGGASKASAGLVTCGSVLKLLNTHHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGSEGGCPRGLPVRCGQAVRLTHVLTGKNLHTHHFPSPLSNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREASVRFQHVGTSVFLSVTGEQYGNPIRGQHEVHGMPSANAHNTWKAMEGIFIKPGADPSTGHDEL", "length": 220 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q93ZE8-1", "protein_name": "Stromal cell-derived factor 2-like protein", "gene_name": "SDF2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALGFFCLAIFLYLSLDPDSGYTSASAAASGKEGVEITYGSAIKLMHEKTKFRLHSHDVPYGSGSGQQSVTGFPGVVDSNSYWIVKPVPGTTEKQGDAVKSGATIRLQHMKTRKWLHSHLHASPISGNLEVSCFGDDTNSDTGDHWKLIIEGSGKTWKQDQRVRLQHIDTSGYLHSHDKKYQRIAGGQQEVCGIREKKADNIWLAAEGVYLPLNESSK", "length": 218 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9ESP1-1", "protein_name": "Stromal cell-derived factor 2-like protein 1", "gene_name": "Sdf2l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWGASRGRVAGPTLLGLLLALSVRSGGASKASAGLVTCGSVLKLLNTHHKVRLHSHDIKYGSGSGQQSVTGVEESDDANSYWRIRGGSEGGCPRGLPVRCGQAVRLTHVLTGKNLHTHHFPSPLSNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREASVRFQHVGTSVFLSVTGEQYGNPIRGQHEVHGMPSANAHNTWKAMEGIFIKPGADLSTGHDEL", "length": 221 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCN8-1", "protein_name": "Stromal cell-derived factor 2-like protein 1", "gene_name": "SDF2L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWSAGRGGAAWPVLLGLLLALLVPGGGAAKTGAELVTCGSVLKLLNTHHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGSEGGCPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLSNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMPSANTHNTWKAMEGIFIKPSVEPSAGHDEL", "length": 221 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VNA3-1", "protein_name": "MIR domain-containing protein", "gene_name": "BEST:LD29996", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQHILLLTGLALVGSISRGAATESNVVTCGSILKLLNSDYAFRLHSHDVKYGSGSGQQSVTGVEQKEDVNSHWVIKAQTGELCERGEPIACGSTVRLEHLSTKKNLHSHHFSSPLSGEQEVSAYGTDGLGDTGDHWEVVCSNENWMRSAHVRLRHIDTGMYLGMSGRSYGRPISGQMEIVGVHKPQHGTRWTTAEGLFIVPKEKSSTHDEYAHSEL", "length": 216 }, "evidence": [ { "id": "Q3T083", "url": "https://omabrowser.org/oma/group/Q3T083/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q3T083", "url": "https://www.uniprot.org/uniprotkb/Q3T083" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q3T083", "url": "https://www.uniprot.org/uniprotkb/Q3T083" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T083-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 221, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T083-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T083" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083" }, { "id": "PRU00131", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00131" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIR 1", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 87, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083" }, { "id": "PRU00131", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00131" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIR 2", "eco_id": "ECO_0000255", "start_pos": 95, "end_pos": 150, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083" }, { "id": "PRU00131", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00131" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIR 3", "eco_id": "ECO_0000255", "start_pos": 151, "end_pos": 205, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T083" }, { "id": "PRU10138", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10138" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Prevents secretion from ER", "eco_id": "ECO_0000255", "start_pos": 218, "end_pos": 221, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T084-1", "uniprot_ac": "Q3T084", "uniprot_id": "TCPW_BOVIN", "mass": { "chemical_mass": 58031.0, "monoisotopic_mass": 58031.0 }, "refseq": { "ac": "NP_001029814", "name": "probable T-complex protein 1 subunit zeta-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" }, "gene_names": [ { "name": "CCT6B", "type": "recommended", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] }, { "name": "CCT6B", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] } ], "protein_names": [ { "name": "Probable T-complex protein 1 subunit zeta-2", "type": "recommended", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.-", "type": "synonym", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084/entry#names_and_taxonomy" } ] }, { "name": "CCT-zeta-2", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] }, { "name": "T-complex protein 1 subunit zeta-2", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] }, { "name": "TCP-1-zeta-2", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] }, { "name": "chaperonin containing TCP1, subunit 6B (zeta 2)", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] }, { "name": "probable T-complex protein 1 subunit zeta-2", "type": "synonym", "evidence": [ { "id": "NP_001029814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814" } ] } ], "function": [ { "annotation": "Could function as a component of a tissue-specific chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis.", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084#function" }, { "database": "UniProtKB", "id": "P40227", "url": "https://www.uniprot.org/uniprotkb/P40227#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCT6B", "url": "https://www.uniprot.org/uniprotkb/Q3T084", "locus": { "chromosome": "19", "start_pos": 15160465, "end_pos": 15120561, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020338", "url": "https://www.ensembl.org/id/ENSBTAG00000020338" } ] } } ], "crossref": [ { "id": "Q3T084", "url": "https://alphafold.ebi.ac.uk/entry/Q3T084", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03342", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03342", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538090", "url": "https://www.ncbi.nlm.nih.gov/gene/538090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538090", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538090", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T084", "url": "https://www.orthodb.org/?gene=Q3T084", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T084-1", "url": "https://www.uniprot.org/uniprotkb/Q3T084-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREIHLDVARTSLQTKVHPQLADVLTEAVVDSVLAIRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVVIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "sp|Q3T084-1|TCPW_BOVIN Isoform 1 of Probable T-complex protein 1 subunit zeta-2 OS=Bos taurus OX=9913 GN=CCT6B PE=2 SV=3 CANONICAL=Q3T084-1" }, "isoforms": [ { "isoform_ac": "Q3T084-1", "url": "https://www.uniprot.org/uniprotkb/Q3T084/entry#Q3T084-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREIHLDVARTSLQTKVHPQLADVLTEAVVDSVLAIRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVVIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "sp|Q3T084-1|TCPW_BOVIN Isoform 1 of Probable T-complex protein 1 subunit zeta-2 OS=Bos taurus OX=9913 GN=CCT6B PE=2 SV=3 CANONICAL=Q3T084-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:538090", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538090", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "Q3T084", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T084-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 531, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T084-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T084" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084#function" }, { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ], "binding_site_uniprot": 90, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 90, "end_pos": 90, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T086-1", "uniprot_ac": "Q3T086", "uniprot_id": "TPC6A_BOVIN", "mass": { "chemical_mass": 17640.0, "monoisotopic_mass": 17640.0 }, "refseq": { "ac": "NP_001029592", "name": "trafficking protein particle complex subunit 6A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592" }, "gene_names": [ { "name": "TRAPPC6A", "type": "recommended", "evidence": [ { "id": "Q3T086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ] }, { "name": "TRAPPC6A", "type": "synonym", "evidence": [ { "id": "NP_001029592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 6A", "type": "recommended", "evidence": [ { "id": "Q3T086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T086/entry#names_and_taxonomy" } ] }, { "name": "TRAPP complex subunit 6A", "type": "synonym", "evidence": [ { "id": "NP_001029592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592" }, { "id": "Q3T086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T086/entry#names_and_taxonomy" } ] }, { "name": "trafficking protein particle complex 6A", "type": "synonym", "evidence": [ { "id": "NP_001029592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592" } ] }, { "name": "trafficking protein particle complex subunit 6A", "type": "synonym", "evidence": [ { "id": "NP_001029592", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592" } ] } ], "function": [ { "annotation": "May play a role in vesicular transport during the biogenesis of melanosomes.", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086#function" }, { "database": "UniProtKB", "id": "Q78XR0", "url": "https://www.uniprot.org/uniprotkb/Q78XR0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC6A", "url": "https://www.uniprot.org/uniprotkb/Q3T086", "locus": {} } ], "crossref": [ { "id": "Q3T086", "url": "https://alphafold.ebi.ac.uk/entry/Q3T086", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14944", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14944", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512261", "url": "https://www.ncbi.nlm.nih.gov/gene/512261", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512261", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512261", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PACELHY", "url": "https://omabrowser.org/oma/group/PACELHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T086", "url": "https://www.orthodb.org/?gene=Q3T086", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029592", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T086-1", "url": "https://www.uniprot.org/uniprotkb/Q3T086-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGGQKTSLLVLEGMGFRVGQALGERLPRETLTFREELDILKFLCKDLWVAVFHKQMDSLRTNHQGTYVLQDNSFPLLVRMASGLQYLEEAPKFLAFTCGLLRGTLSTLGVKSLVTASVAALPACKFQVVIQKL", "length": 159, "header": "sp|Q3T086-1|TPC6A_BOVIN Isoform 1 of Trafficking protein particle complex subunit 6A OS=Bos taurus OX=9913 GN=TRAPPC6A PE=2 SV=1 CANONICAL=Q3T086-1" }, "isoforms": [ { "isoform_ac": "Q3T086-1", "url": "https://www.uniprot.org/uniprotkb/Q3T086/entry#Q3T086-1", "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGGQKTSLLVLEGMGFRVGQALGERLPRETLTFREELDILKFLCKDLWVAVFHKQMDSLRTNHQGTYVLQDNSFPLLVRMASGLQYLEEAPKFLAFTCGLLRGTLSTLGVKSLVTASVAALPACKFQVVIQKL", "length": 159, "header": "sp|Q3T086-1|TPC6A_BOVIN Isoform 1 of Trafficking protein particle complex subunit 6A OS=Bos taurus OX=9913 GN=TRAPPC6A PE=2 SV=1 CANONICAL=Q3T086-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 33, "end_pos": 33, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "site_lbl": "Ser33" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512261", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512261", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "O75865-1", "protein_name": "Trafficking protein particle complex subunit 6A", "gene_name": "TRAPPC6A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADTVLFEFLHTEMVAELWAHDPDPGPGGQKMSLSVLEGMGFRVGQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFLAFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS", "length": 159 }, "evidence": [ { "id": "Q3T086", "url": "https://omabrowser.org/oma/group/Q3T086/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q78XR0-1", "protein_name": "Trafficking protein particle complex subunit 6A", "gene_name": "Trappc6a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADAVLFEFLHTEMVAELWAPDPDPGSGGKRRSLSVLEGLGFRVGQALGERLPLETPAFREELDALKFLCRDLWAAMFQKHMDGLRTNHQGTYVLQDNSFPLLVTMGSGPQYLEEAPKFLAFTCGLLCGALHTLGFQSLVTASVASLPACKFQVVIQKS", "length": 159 }, "evidence": [ { "id": "Q3T086", "url": "https://omabrowser.org/oma/group/Q3T086/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q3T086", "url": "https://www.uniprot.org/uniprotkb/Q3T086" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T086-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T086-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T086" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 33 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T090-1", "uniprot_ac": "Q3T090", "uniprot_id": "TSR2_BOVIN", "mass": { "chemical_mass": 20789.0, "monoisotopic_mass": 20789.0 }, "refseq": { "ac": "NP_001030269", "name": "pre-rRNA-processing protein TSR2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" }, "gene_names": [ { "name": "TSR2", "type": "recommended", "evidence": [ { "id": "Q3T090", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T090" } ] }, { "name": "TSR2", "type": "synonym", "evidence": [ { "id": "NP_001030269", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" } ] } ], "protein_names": [ { "name": "Pre-rRNA-processing protein TSR2 homolog", "type": "recommended", "evidence": [ { "id": "Q3T090", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T090/entry#names_and_taxonomy" } ] }, { "name": "TSR2, 20S rRNA accumulation, homolog", "type": "synonym", "evidence": [ { "id": "NP_001030269", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" } ] }, { "name": "pre-rRNA-processing protein TSR2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030269", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" } ] } ], "function": [ { "annotation": "May be involved in 20S pre-rRNA processing.", "evidence": [ { "database": "UniProtKB", "id": "Q3T090", "url": "https://www.uniprot.org/uniprotkb/Q3T090#function" } ] }, { "annotation": "Using an antibody against the N-terminal part of the bovine protein demonstrated the specific expression of the TSR2 protein in the skin and the hair of the affected and the control cows as well as in bovine fetal skin and hair. Erratum:[PLoS Genet. 2016 May 2;12(5):e1005688. doi: 10.1371/journal.pgen.1005688. PMID: 27135403] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001030269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" }, { "database": "PubMed", "id": "26203908", "url": "https://glygen.org/publication/PubMed/26203908" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T090", "url": "https://www.uniprot.org/uniprotkb/Q3T090" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSR2", "url": "https://www.uniprot.org/uniprotkb/Q3T090", "locus": {} } ], "crossref": [ { "id": "Q3T090", "url": "https://alphafold.ebi.ac.uk/entry/Q3T090", "database": "AlphaFoldDB", "categories": [] }, { "id": "511210", "url": "https://www.ncbi.nlm.nih.gov/gene/511210", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511210", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511210", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSNWGGP", "url": "https://omabrowser.org/oma/group/QSNWGGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T090", "url": "https://www.orthodb.org/?gene=Q3T090", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21250", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21250", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T090", "url": "https://www.uniprot.org/uniprotkb/Q3T090", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T090-1", "url": "https://www.uniprot.org/uniprotkb/Q3T090-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADAAEDSRALFGAAVRAALEAWPALQIAVENGFGGVYSQEKAEWLGGAVEEYFFRNADLELDEVEDFLGELMMNEFDTVVEDGSLPQVSQQLQTMFHHFQKGDRAALKEMASLITQRKCKVRATALPTAGETDEDDDANSVEEMEVAATNDGAATDGVCPQPEPSGPDSQTIKEEDIVEDGWTIVRRKK", "length": 190, "header": "sp|Q3T090-1|TSR2_BOVIN Isoform 1 of Pre-rRNA-processing protein TSR2 homolog OS=Bos taurus OX=9913 GN=TSR2 PE=2 SV=1 CANONICAL=Q3T090-1" }, "isoforms": [ { "isoform_ac": "Q3T090-1", "url": "https://www.uniprot.org/uniprotkb/Q3T090/entry#Q3T090-1", "sequence": { "sequence": "MADAAEDSRALFGAAVRAALEAWPALQIAVENGFGGVYSQEKAEWLGGAVEEYFFRNADLELDEVEDFLGELMMNEFDTVVEDGSLPQVSQQLQTMFHHFQKGDRAALKEMASLITQRKCKVRATALPTAGETDEDDDANSVEEMEVAATNDGAATDGVCPQPEPSGPDSQTIKEEDIVEDGWTIVRRKK", "length": 190, "header": "sp|Q3T090-1|TSR2_BOVIN Isoform 1 of Pre-rRNA-processing protein TSR2 homolog OS=Bos taurus OX=9913 GN=TSR2 PE=2 SV=1 CANONICAL=Q3T090-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation.", "journal": "PLoS genetics", "date": "2015-07", "authors": "Murgiano Leonardo, Shirokova Vera, Welle Monika Maria, Jagannathan Vidhya, Plattet Philippe, Oevermann Anna, Pienkowska-Schelling Aldona, Gallo Daniele, Gentile Arcangelo, Mikkola Marja, Dr\u00f6gem\u00fcller Cord", "evidence": [ { "database": "RefSeq", "id": "NP_001030269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030269" } ], "reference": [ { "type": "PubMed", "id": "26203908", "url": "https://glygen.org/publication/PubMed/26203908" } ] } ], "pathway": [ { "id": "bta:511210", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511210", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HUT4-1", "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Tsr2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMAGAAEDVRTLFGAAIRAALEAWPALQIAVENGFGGVHTQEKAEWLGGAVEDYFIANVDLALEEIEDFLGELMTTEFDTVVEDGSLPQVSQELQTMFQHFQKGDGAALQEMTSNINQKKCKVTATPLKTAKETGVDEEDVDSVEEMEVKEVPVRAWAEVTATNDGTTTDVVCPQPQPSDPDPQTIKEEDIVEDGWTIVRRKK", "length": 203 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q06672-1", "protein_name": "Pre-rRNA-processing protein TSR2", "gene_name": "TSR2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTQYIDETAFVQAEQGKTNLMFSDEKQQARFELGVSMVIYKWDALDVAVENSWGGPDSAEKRDWITGIVVDLFKNEKVVDAALIEETLLYAMIDEFETNVEDDSALPIAVEVINIYNDCFNLNYNKVEKLYLEWQEKQRTKKSKRVVHIEGDDDEDDEDVEDYDDEDEDEEMDEVVPDLVSSKPEPIVDEDGFELVQPKGRRKH", "length": 205 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55C67-1", "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNYSNIVQQNLEQQIQQQQIQQQQEQNLREQQIRQQIEEQIKRGQQNQETTQVDNRPEGEYWQIFDQAVLRIFKEWTALQLAITNEWGGNKTSERAEDMRQDVLDLFLMGKQVYSDQIEKILDECLSQDLNTVAEDDSCKQVATLIIQCYNLAINGAYNDMVSLLGPETASVISSCIKGAGNDSDDEIDAPESEMGDDDYDDEMMDDDDNNDNNNNKPKKYSEPDEDGWVTVNSKRR", "length": 237 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8C8T8-1", "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Tsr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGAAEDVRVLFGAAVRAALEAWPALQIAVENGFGGVHSQEKAEWLGGAVEDYFIANADLELEEIEDFLGELMTTEFDTVVEDGSLPQVSQQLQTMFHHFQKGDGAALQEMTSQINQKKCKVTATPLMTAKETDVAEDDVDSVEEMEVTATNDGATTDEVCPQPQPSDPDTQTIKEEDIVEDGWTIVRRKK", "length": 191 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969E8-1", "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "TSR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAAEDARALFRAGVCAALEAWPALQIAVENGFGGVHSQEKAKWLGGAVEDYFMRNADLELDEVEDFLGELLTNEFDTVVEDGSLPQVSQQLQTMFHHFQRGDGAALREMASCITQRKCKVTATALKTARETDEDEDDVDSVEEMEVTATNDGAATDGVCPQPEPSDPDAQTIKEEDIVEDGWTIVRRKK", "length": 191 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VBI0-1", "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Dmel\\CG14543", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAAQQTEFQKNFRVIVEKIFNHWQDLRLAVEHGMGGRNGQQVAIEIMDYTYQYCVSNENITQGELVEVLEELMDQEFNTLCDDDSIPEICRNLLRYKLMAQQNQFPQIEAELSKLPAGKEWLRPDVKITYTPIDGDSSSDEDMDDSDEEDDNEMGQGDEETPSGSGRMTRSQARKQQAEEFVEPEDGWTTVRRK", "length": 195 }, "evidence": [ { "id": "Q3T090", "url": "https://omabrowser.org/oma/group/Q3T090/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T090", "url": "https://www.uniprot.org/uniprotkb/Q3T090" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "Q3T090", "url": "https://www.uniprot.org/uniprotkb/Q3T090" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T090-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 190, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T090-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T090" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0A0-1", "uniprot_ac": "Q3T0A0", "uniprot_id": "ABHD1_BOVIN", "mass": { "chemical_mass": 44756.0, "monoisotopic_mass": 44756.0 }, "refseq": { "ac": "NP_001030266", "name": "protein ABHD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266" }, "gene_names": [ { "name": "ABHD1", "type": "recommended", "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ] }, { "name": "ABHD1", "type": "synonym", "evidence": [ { "id": "NP_001030266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266" } ] } ], "protein_names": [ { "name": "Protein ABHD1", "type": "recommended", "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.-", "type": "synonym", "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0/entry#names_and_taxonomy" } ] }, { "name": "Abhydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0/entry#names_and_taxonomy" } ] }, { "name": "Alpha/beta hydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0/entry#names_and_taxonomy" } ] }, { "name": "abhydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266" } ] }, { "name": "alpha/beta hydrolase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266" } ] }, { "name": "protein ABHD1", "type": "synonym", "evidence": [ { "id": "NP_001030266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABHD1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0", "locus": { "chromosome": "11", "start_pos": 72508608, "end_pos": 72515568, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007077", "url": "https://www.ensembl.org/id/ENSBTAG00000007077" } ] } } ], "crossref": [ { "id": "Q3T0A0", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0A0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510774", "url": "https://www.ncbi.nlm.nih.gov/gene/510774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510774", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMTTSWG", "url": "https://omabrowser.org/oma/group/MMTTSWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0A0", "url": "https://www.orthodb.org/?gene=Q3T0A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10794", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10794", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10794:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10794:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030266", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0A0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSSQSPQDDTWTESFSLLLGLGAALYLGYYWTWVPQRPQLVTGSRFLAFLEQHCPVTLETFYPTLWCFEGRLQTIFRVLLQSRPVVPYSSEVLETPDGGQILLDWASQSNSQYPDPSTQPTVLLLPGITGSSQETYILHLVDQALKDGYRAVVFNNRGCRGEELLTHRAFCASNTEDLVTVINHIKSRYPQAPLLAVGISLGGILVLNHLARTGRAAGLVAALTLSACWDSFETTRSLETPLNSLLFNHRLTAGLCQVVNRNRKVMDNVVNVDFVLQARTIREFDERYTAVVFGYQDCTAYYQAASPRTKVNAIQIPVLCLNAADDPFSPVDALPLQAAQHSLHVALLVTARGGHIGFLEGLLPWQHCYMSRLLHQYAEAIFQHPAELPGPRSPTPSEAGKS", "length": 404, "header": "sp|Q3T0A0-1|ABHD1_BOVIN Isoform 1 of Protein ABHD1 OS=Bos taurus OX=9913 GN=ABHD1 PE=2 SV=1 CANONICAL=Q3T0A0-1" }, "isoforms": [ { "isoform_ac": "Q3T0A0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0/entry#Q3T0A0-1", "sequence": { "sequence": "MLSSSQSPQDDTWTESFSLLLGLGAALYLGYYWTWVPQRPQLVTGSRFLAFLEQHCPVTLETFYPTLWCFEGRLQTIFRVLLQSRPVVPYSSEVLETPDGGQILLDWASQSNSQYPDPSTQPTVLLLPGITGSSQETYILHLVDQALKDGYRAVVFNNRGCRGEELLTHRAFCASNTEDLVTVINHIKSRYPQAPLLAVGISLGGILVLNHLARTGRAAGLVAALTLSACWDSFETTRSLETPLNSLLFNHRLTAGLCQVVNRNRKVMDNVVNVDFVLQARTIREFDERYTAVVFGYQDCTAYYQAASPRTKVNAIQIPVLCLNAADDPFSPVDALPLQAAQHSLHVALLVTARGGHIGFLEGLLPWQHCYMSRLLHQYAEAIFQHPAELPGPRSPTPSEAGKS", "length": 404, "header": "sp|Q3T0A0-1|ABHD1_BOVIN Isoform 1 of Protein ABHD1 OS=Bos taurus OX=9913 GN=ABHD1 PE=2 SV=1 CANONICAL=Q3T0A0-1" }, "locus": { "chromosome": "11", "start_pos": 72515533, "end_pos": 72508663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009303.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009303.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009303.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009303.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 397, "start_aa": "Thr", "end_pos": 397, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr397", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510774", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510774", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HB79-1", "protein_name": "Protein ABHD1", "gene_name": "Abhd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEYPYITKMLSSSLSSQNGTWSDTVSLLLALGVALYLGYYWACVPQRPRLVAGPQFLAFLEQHCPVTVETFYPTLWCFEGRLQTIFRVLLQSQPEVSYRSEVLQTPDGGQFLLDWAEQSKSSHYLDPTTQPIVLLLPGISGSSQEPYILHLVNQALKDGYRAVVFNNRGCRGEELLTHRAYCASNTEDLETAVKHIKCRYSQAPLLAVGISFGGILVLNYLARTGKAGGLVAGLTMSACWDSFETVDSLETPLNSLLFNQPLTAGLCRLVARNRKTIEKVLDVDFAIKARTIRQLDERYTSVAFGYKDCAAYYQASSPRTKVDAIHTPVLCLNAADDPFSPGHAFPLQAAQQSPYVALLITARGGHIGFLEGLLPRKHCYMNRVLHQYAQAIFQHYMELPDLGALTSEDGKS", "length": 412 }, "evidence": [ { "id": "Q3T0A0", "url": "https://omabrowser.org/oma/group/Q3T0A0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SED3-1", "protein_name": "Protein ABHD1", "gene_name": "ABHD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSSSLNPQNNSWTELFSLLLGLGAVLYLGYYWTWVPQTPRLVTGSQLRAFLEQHCPLTVETFYPTFWCVEGRLQTIFRVFLQSRPVVSYWSEVLQTPDGGQFLLDWAGQHNRSQRPDPSTQPIVLLLPGITGSSQETYILHLVDQALKDGYRAVVFNNRGCRGEELLTYRAYCASNTEDLEAAVNHIKGHYSQAPLLAVGISLGGILVLNYLARTGRAAGVVAGLTVSACWDSFETIRSLESPLNSLLFNQYLTAGLCQVINRNRKVMEKVVNVDSVLQARTIRQFDERYTAVAFGYQDSAAYYRAASPRTKVDAIQIPVLCLNAADDPFSPVHALPLQAAQHSPHVALLVTPRGGHIGFLEGLLPWKHCYMSRLLHQYARAIFQHPEELLSLRVPTLSEGGKS", "length": 405 }, "evidence": [ { "id": "Q3T0A0", "url": "https://omabrowser.org/oma/group/Q3T0A0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RK23-1", "protein_name": "Protein ABHD1", "gene_name": "Abhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEYLHITKMLSSSLSPQNGTWSDAISLLLALGIALYLGYYWACVPQRPRLVAGPQFLAFLEQHCPVTVETFYPTLWCFEGRLQTIFRVLLQSQPVIPYRSEVLQTPDGGQFLLDWAEQPYSSHCPDPTTQPIVLLLPGISGSSQEPYILHLVDQALKDGYRAVVFNNRGCRGEELLTHRAYCASNTEDLETVVKHIKHRYSRAPLLAVGISFGGILVLNYLARTGKAGGLVAGLTMSACWDSFETVDSLETPLNSLLFNQPLTAGLCRLVARNRKSIEKVLDVDFAIKARTIRQLDERYTSVAFGYKDCAAYYHASSPRTKVDAICTPVLCLNAADDPFSPVQALPLQAAQKSPYVALLITARGGHIGFLEGLLPWQHCYMNRVLHQYARAVFQHSVGLPGLGALTPEDGKS", "length": 412 }, "evidence": [ { "id": "Q3T0A0", "url": "https://omabrowser.org/oma/group/Q3T0A0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96SE0-1", "protein_name": "Protein ABHD1", "gene_name": "ABHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSSFLSPQNGTWADTFSLLLALAVALYLGYYWACVLQRPRLVAGPQFLAFLEPHCSITTETFYPTLWCFEGRLQSIFQVLLQSQPLVLYQSDILQTPDGGQLLLDWAKQPDSSQDPDPTTQPIVLLLPGITGSSQETYVLHLVNQALRDGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQAPLLAVGISFGGILVLNHLAQARQAAGLVAALTLSACWDSFETTRSLETPLNSLLFNQPLTAGLCQLVERNRKVIEKVVDIDFVLQARTIRQFDERYTSVAFGYQDCVTYYKAASPRTKIDAIRIPVLYLSAADDPFSPVCALPIQAAQHSPYVALLITARGGHIGFLEGLLPWQHWYMSRLLHQYAKAIFQDPEGLPDLRALLPSEDRNS", "length": 405 }, "evidence": [ { "id": "Q3T0A0", "url": "https://omabrowser.org/oma/group/Q3T0A0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "monoacylglycerol lipase activity", "id": "GO:0047372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047372", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "pmid": "" }, { "name": "acetylesterase activity", "id": "GO:0008126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008126", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "medium-chain fatty acid catabolic process", "id": "GO:0051793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051793", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "pmid": "" }, { "name": "medium-chain fatty acid biosynthetic process", "id": "GO:0051792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051792", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A0", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0A0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0A0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0A0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A0" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AB hydrolase-1", "eco_id": "ECO_0000255", "start_pos": 122, "end_pos": 363, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 397 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0A6-1", "uniprot_ac": "Q3T0A6", "uniprot_id": "BCL7B_BOVIN", "mass": { "chemical_mass": 22197.0, "monoisotopic_mass": 22197.0 }, "refseq": { "ac": "NP_001029947", "name": "B-cell CLL/lymphoma 7 protein family member B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" }, "gene_names": [ { "name": "BCL7B", "type": "recommended", "evidence": [ { "id": "Q3T0A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ] }, { "name": "BCL7B", "type": "synonym", "evidence": [ { "id": "NP_001029947", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" } ] } ], "protein_names": [ { "name": "B-cell CLL/lymphoma 7 protein family member B", "type": "recommended", "evidence": [ { "id": "Q3T0A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6/entry#names_and_taxonomy" } ] }, { "name": "B-cell CLL/lymphoma 7 protein family member B", "type": "synonym", "evidence": [ { "id": "NP_001029947", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" } ] }, { "name": "B-cell CLL/lymphoma 7B", "type": "synonym", "evidence": [ { "id": "NP_001029947", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" } ] }, { "name": "BCL tumor suppressor 7B", "type": "synonym", "evidence": [ { "id": "NP_001029947", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" } ] }, { "name": "BCL7B, BAF complex component", "type": "synonym", "evidence": [ { "id": "NP_001029947", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947" } ] } ], "function": [ { "annotation": "Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6#function" }, { "database": "UniProtKB", "id": "Q9BQE9", "url": "https://www.uniprot.org/uniprotkb/Q9BQE9#function" }, { "database": "UniProtKB", "id": "Q921K9", "url": "https://www.uniprot.org/uniprotkb/Q921K9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL7B", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6", "locus": { "chromosome": "25", "start_pos": 33669371, "end_pos": 33651624, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020544", "url": "https://www.ensembl.org/id/ENSBTAG00000020544" } ] } } ], "crossref": [ { "id": "Q3T0A6", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0A6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020544", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020544", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615062", "url": "https://www.ncbi.nlm.nih.gov/gene/615062", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615062", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615062", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVPVTDN", "url": "https://omabrowser.org/oma/group/WVPVTDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0A6", "url": "https://www.orthodb.org/?gene=Q3T0A6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12767", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12767", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12767:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12767:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9933937", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933937", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933939", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933939", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933946", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933946", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933947", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9934037", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934037", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029947", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0A6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPLETQIAEEEEDSSAPPLKRFCMDQPAVPQTASES", "length": 202, "header": "sp|Q3T0A6-1|BCL7B_BOVIN Isoform 1 of B-cell CLL/lymphoma 7 protein family member B OS=Bos taurus OX=9913 GN=BCL7B PE=2 SV=1 CANONICAL=Q3T0A6-1" }, "isoforms": [ { "isoform_ac": "Q3T0A6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6/entry#Q3T0A6-1", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPLETQIAEEEEDSSAPPLKRFCMDQPAVPQTASES", "length": 202, "header": "sp|Q3T0A6-1|BCL7B_BOVIN Isoform 1 of B-cell CLL/lymphoma 7 protein family member B OS=Bos taurus OX=9913 GN=BCL7B PE=2 SV=1 CANONICAL=Q3T0A6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 114, "end_pos": 114, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser114" }, { "start_pos": 118, "end_pos": 118, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser118" }, { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser120" }, { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser122" }, { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser127" }, { "start_pos": 148, "end_pos": 148, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser148" }, { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "site_lbl": "Ser152" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615062", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615062", "resource": "KEGG Pathway" }, { "id": "R-BTA-9933937", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933937", "resource": "Reactome", "description": "Formation of the canonical BAF (cBAF) complex" }, { "id": "R-BTA-9933939", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933939", "resource": "Reactome", "description": "Formation of the polybromo-BAF (pBAF) complex" }, { "id": "R-BTA-9933946", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933946", "resource": "Reactome", "description": "Formation of the embryonic stem cell BAF (esBAF) complex" }, { "id": "R-BTA-9933947", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "resource": "Reactome", "description": "Formation of the non-canonical BAF (ncBAF) complex" }, { "id": "R-BTA-9934037", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934037", "resource": "Reactome", "description": "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RET8-1", "protein_name": "BAF chromatin remodeling complex subunit BCL7B", "gene_name": "BCL7B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPVETQIAEEEEDSGAPPLKRFCVDQPAVPQTASES", "length": 202 }, "evidence": [ { "id": "Q3T0A6", "url": "https://omabrowser.org/oma/group/Q3T0A6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B1H245-1", "protein_name": "BAF chromatin remodeling complex subunit BCL7B", "gene_name": "Bcl7b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNNTAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPIETQTTEEEEDSGAPPLKRFCVDQPVVPQTTSES", "length": 202 }, "evidence": [ { "id": "Q3T0A6", "url": "https://omabrowser.org/oma/group/Q3T0A6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NWJ0-1", "protein_name": "B-cell CLL/lymphoma 7 protein family member B-A", "gene_name": "bcl7ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIERVRRWEKKWVTVGDTSLRIFKWVPVVDTKEKEKSKVSVGGEMQRKNFPSEESSDNACSVLLDFQDENSNQSSLSDSYQHKAAADSSNNSSPPASEPVSPAPQSLDYRTDDPQPPTLGQEIMEEPLLQSSEIADEPPTLIKEDLLPLTAQEDEDSCGAPPLKRICTEQVSVIQMVPLS", "length": 203 }, "evidence": [ { "id": "Q3T0A6", "url": "https://omabrowser.org/oma/group/Q3T0A6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q921K9-1", "protein_name": "B-cell CLL/lymphoma 7 protein family member B", "gene_name": "Bcl7b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNNTAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPVETQTTEEEEDSGAPPLKRFCVDQPVVPQTTSES", "length": 202 }, "evidence": [ { "id": "Q3T0A6", "url": "https://omabrowser.org/oma/group/Q3T0A6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQE9-1", "protein_name": "B-cell CLL/lymphoma 7 protein family member B", "gene_name": "BCL7B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES", "length": 202 }, "evidence": [ { "id": "Q3T0A6", "url": "https://omabrowser.org/oma/group/Q3T0A6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A6", "url": "https://www.uniprot.org/uniprotkb/Q3T0A6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0A6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 202, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0A6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0A6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 114, 118, 120, 122, 127, 148, 152 ], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0B2-1", "uniprot_ac": "Q3T0B2", "uniprot_id": "PSMD6_BOVIN", "mass": { "chemical_mass": 45533.0, "monoisotopic_mass": 45533.0 }, "refseq": { "ac": "NP_001029821", "name": "26S proteasome non-ATPase regulatory subunit 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821" }, "gene_names": [ { "name": "PSMD6", "type": "recommended", "evidence": [ { "id": "Q3T0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ] }, { "name": "PSMD6", "type": "synonym", "evidence": [ { "id": "NP_001029821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 6", "type": "recommended", "evidence": [ { "id": "Q3T0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome non-ATPase regulatory subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001029821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821" } ] }, { "name": "26S proteasome regulatory subunit RPN7", "type": "synonym", "evidence": [ { "id": "NP_001029821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821" }, { "id": "Q3T0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) 26S subunit, non-ATPase, 6", "type": "synonym", "evidence": [ { "id": "NP_001029821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2#function" }, { "database": "UniProtKB", "id": "Q15008", "url": "https://www.uniprot.org/uniprotkb/Q15008#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD6", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2", "locus": { "chromosome": "22", "start_pos": 37439307, "end_pos": 37420698, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015112", "url": "https://www.ensembl.org/id/ENSBTAG00000015112" } ] } } ], "crossref": [ { "id": "Q3T0B2", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0B2", "database": "AlphaFoldDB", "categories": [] }, { "id": "538625", "url": "https://www.ncbi.nlm.nih.gov/gene/538625", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538625", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538625", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0B2", "url": "https://www.orthodb.org/?gene=Q3T0B2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14145:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14145:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029821", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0B2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLEWQMDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRRTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAIVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEVVETNRPDSKNWQYQETIKKGGLLLNRVQKLSRVINM", "length": 389, "header": "sp|Q3T0B2-1|PSMD6_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 6 OS=Bos taurus OX=9913 GN=PSMD6 PE=2 SV=1 CANONICAL=Q3T0B2-1" }, "isoforms": [ { "isoform_ac": "Q3T0B2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2/entry#Q3T0B2-1", "sequence": { "sequence": "MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLEWQMDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRRTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAIVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEVVETNRPDSKNWQYQETIKKGGLLLNRVQKLSRVINM", "length": 389, "header": "sp|Q3T0B2-1|PSMD6_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 6 OS=Bos taurus OX=9913 GN=PSMD6 PE=2 SV=1 CANONICAL=Q3T0B2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538625", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538625", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ], "pmid": "" }, { "name": "proteasome regulatory particle", "id": "GO:0005838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005838", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B2", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0B2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 389, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0B2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0B2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B2" }, { "id": "PRU01185", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01185" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000255", "start_pos": 193, "end_pos": 361, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0B7-1", "uniprot_ac": "Q3T0B7", "uniprot_id": "RS27L_BOVIN", "mass": { "chemical_mass": 9463.0, "monoisotopic_mass": 9463.0 }, "refseq": { "ac": "NP_001035668", "name": "small ribosomal subunit protein eS27-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035668" }, "gene_names": [ { "name": "LOC101905167", "type": "recommended", "evidence": [ { "id": "Q3T0B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ] }, { "name": "RPS27L", "type": "recommended", "evidence": [ { "id": "Q3T0B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ] }, { "name": "RPS27L", "type": "synonym", "evidence": [ { "id": "NP_001035668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035668" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein eS27-like", "type": "recommended", "evidence": [ { "id": "Q3T0B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S27-like protein", "type": "synonym", "evidence": [ { "id": "NP_001035668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035668" } ] }, { "name": "40S ribosomal protein S27-like", "type": "synonym", "evidence": [ { "id": "Q3T0B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7/entry#names_and_taxonomy" } ] }, { "name": "small ribosomal subunit protein eS27-like", "type": "synonym", "evidence": [ { "id": "NP_001035668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035668" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS27L", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7", "locus": { "chromosome": "3", "start_pos": 100747193, "end_pos": 100746655, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040435", "url": "https://www.ensembl.org/id/ENSBTAG00000040435" } ] } } ], "crossref": [ { "id": "Q3T0B7", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0B7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614220", "url": "https://www.ncbi.nlm.nih.gov/gene/614220", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T0B7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T0B7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000592", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000592", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614220", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614220", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERINMPL", "url": "https://omabrowser.org/oma/group/ERINMPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0B7", "url": "https://www.orthodb.org/?gene=Q3T0B7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11594", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11594", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01667", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01667", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035668", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SL48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYB6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0B7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLARDLLHPSLDEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 84, "header": "sp|Q3T0B7-1|RS27L_BOVIN Isoform 1 of Small ribosomal subunit protein eS27-like OS=Bos taurus OX=9913 GN=RPS27L PE=3 SV=3 CANONICAL=Q3T0B7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL48-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7/entry#A0AAA9SL48-1", "sequence": { "sequence": "MGARLSTSPLPALADPGRSQPLPPRGAPRGTSPPLRSSQPPVSRKLTPRASSRAARWGCRLRDLHGLGLRKDQHACELFTFGLRVCVGLLCRPRGPEDRLDSWLRWAPGLPAERRSAPRMARLFRAWRTCWDLPERRGEPGPARAWNWKPGAALGCGLELLVGRELLPAYLTQPSWVSLARDLLHPSLDEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 260, "header": "tr|A0AAA9SL48-1|A0AAA9SL48_BOVIN Computationally mapped isoform of 40S ribosomal protein S27 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3T0B7-1" }, "locus": {} }, { "isoform_ac": "A0AAF6YYB6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7/entry#A0AAF6YYB6-1", "sequence": { "sequence": "ICQSCGIILVLILLFGFFVQLARDLLHPSLDEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 102, "header": "tr|A0AAF6YYB6-1|A0AAF6YYB6_BOVIN Computationally mapped isoform of 40S ribosomal protein S27 OS=Bos taurus OX=9913 GN=LOC101905167 PE=3 SV=1 CANONICAL=Q3T0B7-1" }, "locus": { "chromosome": "10", "start_pos": 46892448, "end_pos": 46890098, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017146.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017146.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017146.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017146.5" } ] } }, { "isoform_ac": "Q3T0B7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7/entry#Q3T0B7-1", "sequence": { "sequence": "MPLARDLLHPSLDEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 84, "header": "sp|Q3T0B7-1|RS27L_BOVIN Isoform 1 of Small ribosomal subunit protein eS27-like OS=Bos taurus OX=9913 GN=RPS27L PE=3 SV=3 CANONICAL=Q3T0B7-1" }, "locus": { "chromosome": "3", "start_pos": 100747013, "end_pos": 100746762, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139552.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139552.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105097.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614220", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614220", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2TV39-1", "protein_name": "40S ribosomal protein S27", "gene_name": "RPS27L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPLARDLLHPSLEEERRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTILCQPTGGKARLTEGCSFRRKQH", "length": 84 }, "evidence": [ { "id": "Q3T0B7", "url": "https://omabrowser.org/oma/group/Q3T0B7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TYR3-1", "protein_name": "40S ribosomal protein S27", "gene_name": "RPS27L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 84 }, "evidence": [ { "id": "Q3T0B7", "url": "https://omabrowser.org/oma/group/Q3T0B7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6ZWY3-1", "protein_name": "Small ribosomal subunit protein eS27-like", "gene_name": "Rps27l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 84 }, "evidence": [ { "id": "Q3T0B7", "url": "https://omabrowser.org/oma/group/Q3T0B7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q71UM5-1", "protein_name": "Ribosomal protein eS27-like", "gene_name": "RPS27L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH", "length": 84 }, "evidence": [ { "id": "Q3T0B7", "url": "https://omabrowser.org/oma/group/Q3T0B7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" }, { "name": "ribosomal small subunit assembly", "id": "GO:0000028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000028", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3T0B7", "url": "https://www.uniprot.org/uniprotkb/Q3T0B7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0B7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 84, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0B7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0B7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0E0-1", "uniprot_ac": "Q3T0E0", "uniprot_id": "ATOX1_BOVIN", "mass": { "chemical_mass": 7365.0, "monoisotopic_mass": 7365.0 }, "refseq": { "ac": "NP_001124230", "name": "copper transport protein ATOX1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230" }, "gene_names": [ { "name": "ATOX1", "type": "recommended", "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ] }, { "name": "ATOX1", "type": "synonym", "evidence": [ { "id": "NP_001124230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230" } ] } ], "protein_names": [ { "name": "Copper transport protein ATOX1", "type": "recommended", "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0/entry#names_and_taxonomy" } ] }, { "name": "ATX1 antioxidant protein 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001124230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230" } ] }, { "name": "Metal transport protein ATX1", "type": "synonym", "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0/entry#names_and_taxonomy" } ] }, { "name": "copper transport protein ATOX1", "type": "synonym", "evidence": [ { "id": "NP_001124230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230" } ] }, { "name": "metal transport protein ATX1", "type": "synonym", "evidence": [ { "id": "NP_001124230", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230" } ] } ], "function": [ { "annotation": "Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATOX1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0", "locus": { "chromosome": "7", "start_pos": 62942179, "end_pos": 62957525, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008340", "url": "https://www.ensembl.org/id/ENSBTAG00000008340" } ] } } ], "crossref": [ { "id": "Q3T0E0", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0E0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008340", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008340", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00371", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00371", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613998", "url": "https://www.ncbi.nlm.nih.gov/gene/613998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613998", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613998", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTHTYKF", "url": "https://omabrowser.org/oma/group/MTHTYKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0E0", "url": "https://www.orthodb.org/?gene=Q3T0E0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46365", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46365", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46365:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46365:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001124230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124230", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0E0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKHEFSVDMTCEGCSNAVTRVLNKLGGVQFDIDLPNKKVCINSEHSVDTLLETLGKTGKAVSYLGPK", "length": 68, "header": "sp|Q3T0E0-1|ATOX1_BOVIN Isoform 1 of Copper transport protein ATOX1 OS=Bos taurus OX=9913 GN=ATOX1 PE=3 SV=1 CANONICAL=Q3T0E0-1" }, "isoforms": [ { "isoform_ac": "Q3T0E0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0/entry#Q3T0E0-1", "sequence": { "sequence": "MPKHEFSVDMTCEGCSNAVTRVLNKLGGVQFDIDLPNKKVCINSEHSVDTLLETLGKTGKAVSYLGPK", "length": 68, "header": "sp|Q3T0E0-1|ATOX1_BOVIN Isoform 1 of Copper transport protein ATOX1 OS=Bos taurus OX=9913 GN=ATOX1 PE=3 SV=1 CANONICAL=Q3T0E0-1" }, "locus": { "chromosome": "7", "start_pos": 62957474, "end_pos": 62945928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010982.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010982.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010982.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010982.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 47, "end_pos": 47, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "site_lbl": "Ser47" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613998", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613998", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GE91-1", "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKLKPGGRAENPHRDAGTCPFQKHEFSVDMSCEGCAEAVSRVLNKLGGVQFNIDLPNKKVCIESEHNPDTLLATLNKTGKTVSYLGPK", "length": 89 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M9PD88-1", "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTVHEFKVEMTCGGCASAVERVLGKLGDKVEKVNINLEDRTVSVTSNLSSDELMEQLRKTGKSTTYVGVKKXDEFLSKFQKYGRLKLEV", "length": 89 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O00244-1", "protein_name": "Copper transport protein ATOX1", "gene_name": "ATOX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE", "length": 68 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O08997-1", "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKHEFSVDMTCEGCAEAVSRVLNKLGGVEFNIDLPNKKVCIDSEHSSDTLLATLNKTGKAVSYLGPK", "length": 68 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54PZ2-1", "protein_name": "Copper transport protein ATOX1 homolog", "gene_name": "atox1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTYSFFVDMTCGGCSKAVNAILSKIDGVSNIQIDLENKKVSCESSKMGADELLKNIQKTGKKCSIIA", "length": 67 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9WUC4-1", "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKHEFSVDMTCGGCAEAVSRVLNKLGGVEFNIDLPNKKVCIESEHSSDILLATLNKTGKAVSYLGPK", "length": 68 }, "evidence": [ { "id": "Q3T0E0", "url": "https://omabrowser.org/oma/group/Q3T0E0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "pmid": "" }, { "name": "copper chaperone activity", "id": "GO:0016531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016531", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "copper ion transport", "id": "GO:0006825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006825", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E0", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0E0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 68, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0E0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0E0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" }, { "id": "PRU00280", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00280" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMA", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 63, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0#function" }, { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" }, { "id": "PRU00280", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00280" } ], "binding_site_uniprot": 12, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_23378", "ligand": "Cu cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 12, "end_pos": 12, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0#function" }, { "id": "Q3T0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E0" }, { "id": "PRU00280", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00280" } ], "binding_site_uniprot": 15, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_23378", "ligand": "Cu cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 15, "end_pos": 15, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 47 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0E8-1", "uniprot_ac": "Q3T0E8", "uniprot_id": "CALL4_BOVIN", "mass": { "chemical_mass": 17826.0, "monoisotopic_mass": 17826.0 }, "refseq": { "ac": "NP_001029843", "name": "calmodulin-like protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029843" }, "gene_names": [ { "name": "CALML4", "type": "recommended", "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ] }, { "name": "CALML4", "type": "synonym", "evidence": [ { "id": "NP_001029843", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029843" } ] } ], "protein_names": [ { "name": "Calmodulin-like protein 4", "type": "recommended", "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8/entry#names_and_taxonomy" } ] }, { "name": "calmodulin-like protein 4", "type": "synonym", "evidence": [ { "id": "NP_001029843", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029843" } ] } ], "function": [ { "annotation": "As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8#function" }, { "database": "UniProtKB", "id": "Q96GE6", "url": "https://www.uniprot.org/uniprotkb/Q96GE6#function" }, { "database": "UniProtKB", "id": "A0AAA9RTA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTA5#function" }, { "database": "UniProtKB", "id": "ARBA00054485", "url": "https://www.uniprot.org/uniprotkb/ARBA00054485#function" }, { "database": "UniProtKB", "id": "A0A452DJ75", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ75#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CALML4", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8", "locus": { "chromosome": "10", "start_pos": 15035519, "end_pos": 15045112, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025822", "url": "https://www.ensembl.org/id/ENSBTAG00000025822" } ] } } ], "crossref": [ { "id": "Q3T0E8", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0E8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025822", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025822", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539277", "url": "https://www.ncbi.nlm.nih.gov/gene/539277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539277", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYEAFTQ", "url": "https://omabrowser.org/oma/group/NYEAFTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ75", "url": "https://www.orthodb.org/?gene=A0A452DJ75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T0E8", "url": "https://www.orthodb.org/?gene=Q3T0E8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029843", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ75", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ75-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0E8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPGEAQRHLQTHRIDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY", "length": 153, "header": "sp|Q3T0E8-1|CALL4_BOVIN Isoform 1 of Calmodulin-like protein 4 OS=Bos taurus OX=9913 GN=CALML4 PE=2 SV=1 CANONICAL=Q3T0E8-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ75-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8/entry#A0A452DJ75-1", "sequence": { "sequence": "MAAVDLLPGPPPRRADFRLEAGKGNRKAVLGAASPRVAAGGPAMAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPGEAQRHLQTHRIDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY", "length": 196, "header": "tr|A0A452DJ75-1|A0A452DJ75_BOVIN Computationally mapped isoform of Calmodulin-like protein 4 OS=Bos taurus OX=9913 GN=CALML4 PE=3 SV=1 CANONICAL=Q3T0E8-1" }, "locus": { "chromosome": "10", "start_pos": 15044913, "end_pos": 15035726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036523.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036523.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036380.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036380.5" } ] } }, { "isoform_ac": "A0AAA9RTA5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8/entry#A0AAA9RTA5-1", "sequence": { "sequence": "MLGEYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPGEAQRHLQTHRIDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY", "length": 145, "header": "tr|A0AAA9RTA5-1|A0AAA9RTA5_BOVIN Computationally mapped isoform of Calmodulin-like protein 4 OS=Bos taurus OX=9913 GN=CALML4 PE=3 SV=1 CANONICAL=Q3T0E8-1" }, "locus": { "chromosome": "10", "start_pos": 15044491, "end_pos": 15035726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075052.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075052.1" } ] } }, { "isoform_ac": "A0AAA9SE87-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8/entry#A0AAA9SE87-1", "sequence": { "sequence": "MAKFLSQDQINDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY", "length": 106, "header": "tr|A0AAA9SE87-1|A0AAA9SE87_BOVIN Computationally mapped isoform of Calmodulin like 4 OS=Bos taurus OX=9913 GN=CALML4 PE=4 SV=1 CANONICAL=Q3T0E8-1" }, "locus": { "chromosome": "10", "start_pos": 15044784, "end_pos": 15035726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082146.1" } ] } }, { "isoform_ac": "Q3T0E8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8/entry#Q3T0E8-1", "sequence": { "sequence": "MAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPGEAQRHLQTHRIDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY", "length": 153, "header": "sp|Q3T0E8-1|CALL4_BOVIN Isoform 1 of Calmodulin-like protein 4 OS=Bos taurus OX=9913 GN=CALML4 PE=2 SV=1 CANONICAL=Q3T0E8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 45, "start_aa": "Thr", "end_pos": 45, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539277", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1ZQ52-1", "protein_name": "Calmodulin-like protein 4", "gene_name": "CALML4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "KYKFQINQYLLHKYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPVEAQRHLQTHKIDKNGELDFSTFLTIMHMQMKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMKLGEKLTHKEVDDLFKEADIEPNGKVKYDEFIHKVTIPVQDY", "length": 154 }, "evidence": [ { "id": "Q3T0E8", "url": "https://omabrowser.org/oma/group/Q3T0E8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7F9Q8-1", "protein_name": "Calmodulin-like protein 4", "gene_name": "Calml4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGASAVQLQSDSRGIGPSLHGSRGFITRPPPSLVDFRLQAGVKRTKHSSRSQGCLRMAKFLSQEQINEYKECFSLYDKQQRGKIKATDLLVSMRCLGASPTPGEVQRHLQTHGIDKNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMTDKEKKGYIMASELRSKLMKLGEKLTHKEVDELFKEAGIEPNGQVKYDTFIQRITLPVRDY", "length": 210 }, "evidence": [ { "id": "Q3T0E8", "url": "https://omabrowser.org/oma/group/Q3T0E8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91WQ9-1", "protein_name": "Calmodulin-like protein 4", "gene_name": "Calml4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLVSMRCLGASPTPGEVQRHLQTHGIDKNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMKLGEKLTHKEVDDLFKEAGIEPNGQVKYDTFIQRITIPVRDY", "length": 153 }, "evidence": [ { "id": "Q3T0E8", "url": "https://omabrowser.org/oma/group/Q3T0E8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96GE6-1", "protein_name": "Calmodulin-like protein 4", "gene_name": "CALML4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAEHLLPGPPPSLADFRLEAGGKGTERGSGSSKPTGSSRGPRMAKFLSQDQINEYKECFSLYDKQQRGKIKATDLMVAMRCLGASPTPGEVQRHLQTHGIDGNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMVDKEKKGYVMASDLRSKLTSLGEKLTHKEVDDLFREADIEPNGKVKYDEFIHKITLPGRDY", "length": 196 }, "evidence": [ { "id": "Q3T0E8", "url": "https://omabrowser.org/oma/group/Q3T0E8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDI3-1", "protein_name": "Myosin-2 essential light chain", "gene_name": "Dmel\\CG17272", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MARYFKEQDIDEFRECFYLFARSGQINNLDELTVIMRSLGLSPTIQELVSYLKQKNGKMSFADFLDIMHQHSKVESLPDEVIAAFKAADPQNKGTISARQLRNLLQNWGEGLSMREVDNIFREANVNNNSTVRYADFVKIACAPVPDYY", "length": 149 }, "evidence": [ { "id": "Q3T0E8", "url": "https://omabrowser.org/oma/group/Q3T0E8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" }, { "name": "enzyme regulator activity", "id": "GO:0030234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030234", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" }, { "name": "myosin head/neck binding", "id": "GO:0032028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032028", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" }, { "name": "brush border assembly", "id": "GO:1904970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904970", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E8", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0E8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0E8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0E8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 1", "eco_id": "ECO_0000255", "start_pos": 8, "end_pos": 43, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 2", "eco_id": "ECO_0000255", "start_pos": 44, "end_pos": 79, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 3", "eco_id": "ECO_0000255", "start_pos": 81, "end_pos": 116, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E8" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 4", "eco_id": "ECO_0000255", "start_pos": 117, "end_pos": 152, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 45 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0F2-1", "uniprot_ac": "Q3T0F2", "uniprot_id": "TPPC2_BOVIN", "mass": { "chemical_mass": 16415.0, "monoisotopic_mass": 16415.0 }, "refseq": { "ac": "NP_001029968", "name": "trafficking protein particle complex subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029968" }, "gene_names": [ { "name": "TRAPPC2", "type": "recommended", "evidence": [ { "id": "Q3T0F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ] }, { "name": "TRAPPC2", "type": "synonym", "evidence": [ { "id": "NP_001029968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029968" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 2", "type": "recommended", "evidence": [ { "id": "Q3T0F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2/entry#names_and_taxonomy" } ] }, { "name": "trafficking protein particle complex 2", "type": "synonym", "evidence": [ { "id": "NP_001029968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029968" } ] }, { "name": "trafficking protein particle complex subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001029968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029968" } ] } ], "function": [ { "annotation": "Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2", "locus": { "chromosome": "X", "start_pos": 129808212, "end_pos": 129796070, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010922", "url": "https://www.ensembl.org/id/ENSBTAG00000010922" } ] } } ], "crossref": [ { "id": "Q3T0F2", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0F2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14825", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14825", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616748", "url": "https://www.ncbi.nlm.nih.gov/gene/616748", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T0F2", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T0F2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616748", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616748", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYMNQFI", "url": "https://omabrowser.org/oma/group/RYMNQFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0F2", "url": "https://www.orthodb.org/?gene=Q3T0F2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029968", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0F2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140, "header": "sp|Q3T0F2-1|TPPC2_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2 OS=Bos taurus OX=9913 GN=TRAPPC2 PE=2 SV=1 CANONICAL=Q3T0F2-1" }, "isoforms": [ { "isoform_ac": "Q3T0F2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2/entry#Q3T0F2-1", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140, "header": "sp|Q3T0F2-1|TPPC2_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2 OS=Bos taurus OX=9913 GN=TRAPPC2 PE=2 SV=1 CANONICAL=Q3T0F2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616748", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616748", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MDF4-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "Trappc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPPGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SRI0-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "TRAPPC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4HTY0-1", "protein_name": "SNARE-like superfamily protein", "gene_name": "TRAPPC2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MANTACFIIVGRNDIPIYEAEVGSAAKREDAAQLHQFILHAALDVVQDLAWTTSAMFLKSVDRFNDLVVSVYVTAGHTRLMLLHDSRNEDGIKSFFQEVHELYIKILLNPLYLPGSRITSSHFDTKVRALARKYL", "length": 135 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DI81-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "TRAPPC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DI82-1", "protein_name": "Trafficking protein particle complex subunit 2B", "gene_name": "TRAPPC2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P38334-1", "protein_name": "Trafficking protein particle complex subunit 20", "gene_name": "TRS20", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPQYFAIIGKKDNPVYEIEFTNAENPQGFPQDLKELNPFILHASLDIVEDLQWQINPTSQLNGNGGNGSNGGGGFLRSRAVNNTDNCYLGKVDHFYGLAITAYISYSGMKFVMIHGNSANSSVVIDDNNMRSFYQEVHELYVKTLMNPFYKITDPIRSPAFDSRVRTLARKHLSK", "length": 175 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q08CN0-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "trappc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGSFYFVMVGHHDNPVFELEFLPPGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFNDVYDLYVKFAMNPFYEVNAPIRSTAFERKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54RV6-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "trappc2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTFTFLIIGKNDNPLYEIEFPITVQKKETYVLQYIAHGSLDIVEEHVWKSNNMYLKIIDKFNKVQISSFVTAGHIKFLLLHEKKDEDAIKNFFVEVHDLYLKILLNPFYEYNKPITSTAFDAKVRKIGTKYF", "length": 133 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CQP2-1", "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "Trappc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPPGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 140 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VUZ1-1", "protein_name": "Probable trafficking protein particle complex subunit 2", "gene_name": "Trs20", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTYYFVIVGQNDNPIYEKEFSTVNKELRKEDHRHLTQFIAHAALDLVDEHKWKTANMQLKSIDRFNQWFVSAFITASQIRFIIVHDNKNDEGIKNFFNEMYDTYIKNSMNAFYRINTPIKSPMFEKKSEIFGRKYLLS", "length": 139 }, "evidence": [ { "id": "Q3T0F2", "url": "https://omabrowser.org/oma/group/Q3T0F2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q3T0F2", "url": "https://www.uniprot.org/uniprotkb/Q3T0F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0F2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0F2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0F2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0G5-1", "uniprot_ac": "Q3T0G5", "uniprot_id": "PLPHP_BOVIN", "mass": { "chemical_mass": 29943.0, "monoisotopic_mass": 29943.0 }, "refseq": { "ac": "NP_001029529", "name": "pyridoxal phosphate homeostasis protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" }, "gene_names": [ { "name": "PLPBP", "type": "recommended", "evidence": [ { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ] }, { "name": "PLPBP", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] }, { "name": "PROSC", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" }, { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ] } ], "protein_names": [ { "name": "Pyridoxal phosphate homeostasis protein", "type": "recommended", "evidence": [ { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#names_and_taxonomy" } ] }, { "name": "PLP homeostasis protein", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" }, { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#names_and_taxonomy" } ] }, { "name": "Proline synthase co-transcribed bacterial homolog protein", "type": "synonym", "evidence": [ { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#names_and_taxonomy" } ] }, { "name": "Pyridoxal phosphate-binding protein", "type": "synonym", "evidence": [ { "id": "Q3T0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#names_and_taxonomy" } ] }, { "name": "proline synthase co-transcribed bacterial homolog protein", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] }, { "name": "proline synthetase co-transcribed bacterial homolog protein", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] }, { "name": "proline synthetase co-transcribed homolog", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] }, { "name": "proline synthetase cotranscribed homolog", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] }, { "name": "pyridoxal phosphate homeostasis protein", "type": "synonym", "evidence": [ { "id": "NP_001029529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529" } ] } ], "function": [ { "annotation": "Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDS8#function" }, { "database": "HAMAP", "id": "MF_03225", "url": "https://hamap.expasy.org/signature/MF_03225" }, { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5#function" }, { "database": "UniProtKB", "id": "A0AAA9T3V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLPBP", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5", "locus": { "chromosome": "27", "start_pos": 33052078, "end_pos": 33042538, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011075", "url": "https://www.ensembl.org/id/ENSBTAG00000011075" } ] } } ], "crossref": [ { "id": "Q3T0G5", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0G5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011075", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06822", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06822", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509643", "url": "https://www.ncbi.nlm.nih.gov/gene/509643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PLEWHMI", "url": "https://omabrowser.org/oma/group/PLEWHMI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0G5", "url": "https://www.orthodb.org/?gene=Q3T0G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10146:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10146:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0G5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWKAGSMSAELGIGFALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYSHGQRTFGENYVQELLEKASNPQILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSVKLADKVNSAWQKKGSPERLKVMVQINTSGEASKHGLPPAEMAALVEHINAKCPSLEFVGLMTIGSFGHDLSQGPNPDFQVLLSLREELCRKLGAPPEQVELSMGMSVDFQHAIEVGSTNVRIGSTIFGERDYSKKTDKPAAELQAPEEVAQAH", "length": 273, "header": "sp|Q3T0G5-1|PLPHP_BOVIN Isoform 1 of Pyridoxal phosphate homeostasis protein OS=Bos taurus OX=9913 GN=PLPBP PE=2 SV=1 CANONICAL=Q3T0G5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3V8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#A0AAA9T3V8-1", "sequence": { "sequence": "MLTLKESEVAKTGLSLCDSTDCSPPDSSVYGIFQDLPAIQPRLVAVSKTKPADMVIEAYSHGQRTFGENYVQELLEKASNPQILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSVKLADKVNSAWQKKGSPERLKVMVQINTSGEASKHGLPPAEMAALVEHINAKCPSLEFVGLMTIGSFGHDLSQGPNPDFQVLLSLREELCRKLGAPPEQVELSMGMSVDFQHAIEVGSTNVRIGSTIFGERDYSKKTDKPAAELQAPEEVAQAH", "length": 274, "header": "tr|A0AAA9T3V8-1|A0AAA9T3V8_BOVIN Computationally mapped isoform of Pyridoxal phosphate homeostasis protein OS=Bos taurus OX=9913 GN=PLPBP PE=1 SV=1 CANONICAL=Q3T0G5-1" }, "locus": { "chromosome": "27", "start_pos": 33050856, "end_pos": 33043409, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109401.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109401.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091177.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091177.1" } ] } }, { "isoform_ac": "A0AAA9TDS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#A0AAA9TDS8-1", "sequence": { "sequence": "MWKAGSMSAELGIGFALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYSHGQRTFGENYVQELLEKASNPQILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSVKLADKVNSAWQKKGSPERLKVMVQINTSGEASKHGLPPAEMAALVEHINAKCPSLEFVGLMTIGSFGHDLSQGPNPDFQVLLSLREELCRKLGAPPEQVELSMGMSVDFQHAVSISRVPSGACRTGPKATPRRRIEAPRGSVSHLR", "length": 266, "header": "tr|A0AAA9TDS8-1|A0AAA9TDS8_BOVIN Computationally mapped isoform of Pyridoxal phosphate homeostasis protein OS=Bos taurus OX=9913 GN=PLPBP PE=1 SV=1 CANONICAL=Q3T0G5-1" }, "locus": { "chromosome": "27", "start_pos": 33049201, "end_pos": 33042558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124559.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124559.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096771.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096771.1" } ] } }, { "isoform_ac": "Q3T0G5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5/entry#Q3T0G5-1", "sequence": { "sequence": "MWKAGSMSAELGIGFALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYSHGQRTFGENYVQELLEKASNPQILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSVKLADKVNSAWQKKGSPERLKVMVQINTSGEASKHGLPPAEMAALVEHINAKCPSLEFVGLMTIGSFGHDLSQGPNPDFQVLLSLREELCRKLGAPPEQVELSMGMSVDFQHAIEVGSTNVRIGSTIFGERDYSKKTDKPAAELQAPEEVAQAH", "length": 273, "header": "sp|Q3T0G5-1|PLPHP_BOVIN Isoform 1 of Pyridoxal phosphate homeostasis protein OS=Bos taurus OX=9913 GN=PLPBP PE=2 SV=1 CANONICAL=Q3T0G5-1" }, "locus": { "chromosome": "27", "start_pos": 33050856, "end_pos": 33042558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039812.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039812.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039600.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039600.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 226, "end_pos": 226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "site_lbl": "Ser226" }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "site_lbl": "Ser244" }, { "start_pos": 69, "end_pos": 69, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "site_lbl": "Tyr69" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509643", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5YBG7-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Plpbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRGGSMTAELGVGLALRAVNERVQQSVARRPRGLPAIQPRLVAVSKTKPTEMVIEAYGHGQRTFGENYVQELLEKASNPTLLSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETIDSVKLADKVNSSWQKKGSPERLKVMVQINTSGEDSKHGLLPSETVAVVEHIKASCPNLEFVGLMTIGSFGHDLSQGPNPDFQRLLSLRQELCEKLGLPVEQVELSMGMSVDFQHAIEVGSTNIRVGSTIFGERDYSKKPAPDKTTIDLTASVPLVQGQ", "length": 275 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7F980-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Plpbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWRAGSMSTELGLGFALRAVNERVQQSVSRRRRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKVLSSCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSMKLADKVNSSWQKKGSTERLKVMVQINTSGEESKHGLPSSEAIAVVEHIKASCPNLEFVGLMTIGSFGHDLSQGPNPDFQMLLRLRQELCEKLNIPVDQVELSMGMSADFQHAIEVGSTNVRVGSTIFGERDYSKKPALDKTTTDLKTSVSLVQEQ", "length": 275 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RX84-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "PLPBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWKAGSMSAELGIGFALRAVNERVQQAVARRPRELPAIQPRLVAVSKTKPADMVIEAYNHGQRIFGENYVQELLEKASNPKILSSCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSMKLADKVNSSWQKKGSPERLKVMVQVNTSGEESKHGLLPSETVAMVEHVKAKCPSLEFVGLMTIGSFGHDLSQGPNPDFQVLVSLREELCQKLHIPVDQVELSMGMSVDFQHAIEVGSTNVRIGSTIFGERDYSKKAALDKPTAELKAPVEMAQAH", "length": 275 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O94903-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "PLPBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH", "length": 275 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P38197-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTGITYDEDRKTQLIAQYESVREVVNAEAKNVHVNENASKILLLVVSKLKPASDIQILYDHGVREFGENYVQELIEKAKLLPDDIKWHFIGGLQTNKCKDLAKVPNLYSVETIDSLKKAKKLNESRAKFQPDCNPILCNVQINTSHEDQKSGLNNEAEIFEVIDFFLSEECKYIKLNGLMTIGSWNVSHEDSKENRDFATLVEWKKKIDAKFGTSLKLSMGMSADFREAIRQGTAEVRIGTDIFGARPPKNEARII", "length": 257 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q1ZXI6-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "prosc", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMDENDVKELISSYKNIKDRVEIISNKFDRHNVKLVAVSKTKPTEMIRILYDKGHRHFGENYIQELVSKSEELSELNEIKWHFIGSIQSNKSKILTSVKNLYVVETVENKKILDKLAKSLLNNEENNNNNNNNNNKKLNIMIQVNTSGEESKSGCKPEECLDLVKHCLEDNNCKNSLNFLGLMTIGNPNATPDQPDFKCLVDCKNNISKQLNIPLDSIELSMGMSHDFEPAIEFGSTSVRVGSAIFGERDYSNKK", "length": 255 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VA97-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Dmel\\CG1983", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRRTMAEFDVKAGLQHVLKRIDEVLLQRPKEVQAARPLLVAVSKTKPAEAVIEAYEGGQRDFGENYVQELEEKSRHPDILAKCPDIRWHFIGHMQSNKINKILSVPNLHMIQTVDSEKLATKLDAAWSKRQPTPEEPLQVLIQINTSGEDVKSGIEAKDAPALYQYIKSNLKHLNLMGIMTIGAFGFDYSNGPNPDFVSLMQVHRSICEAHSLAPDSVLVSMGMSNDFDKAIEMGSTVVRVGSSIFGHRAAKV", "length": 254 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z2Y8-1", "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Plpbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRGGSMTAELGVGFALRAVNERVQQSVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSVKLADKVNSSWQKKGPTEPLKVMVQINTSGEDSKHGLLPSETIAVVEHIKASCPSLEFVGLMTIGSFGHDLSQGPNPDFQRLLTLRRELCEKLGIPVEQVELSMGMSMDFQHAIEVGSTNVRIGSTIFGERDYSKKPALDKTADAKASVPLVQGH", "length": 274 }, "evidence": [ { "id": "Q3T0G5", "url": "https://omabrowser.org/oma/group/Q3T0G5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "vitamin B6 metabolic process", "id": "GO:0042816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042816", "evidence": [ { "database": "UniProtKB", "id": "Q3T0G5", "url": "https://www.uniprot.org/uniprotkb/Q3T0G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0G5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 273, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0G5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0G5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 6, 69, 226, 244 ], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 146, "end_pos": 148 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0M2-1", "uniprot_ac": "Q3T0M2", "uniprot_id": "SFXN4_BOVIN", "mass": { "chemical_mass": 35426.0, "monoisotopic_mass": 35426.0 }, "refseq": { "ac": "NP_001030232", "name": "sideroflexin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030232" }, "gene_names": [ { "name": "SFXN4", "type": "recommended", "evidence": [ { "id": "Q3T0M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ] }, { "name": "SFXN4", "type": "synonym", "evidence": [ { "id": "NP_001030232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030232" } ] } ], "protein_names": [ { "name": "Sideroflexin-4", "type": "recommended", "evidence": [ { "id": "Q3T0M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2/entry#names_and_taxonomy" } ] }, { "name": "sideroflexin-4", "type": "synonym", "evidence": [ { "id": "NP_001030232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030232" } ] } ], "function": [ { "annotation": "Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2#function" }, { "database": "UniProtKB", "id": "Q6P4A7", "url": "https://www.uniprot.org/uniprotkb/Q6P4A7#function" }, { "database": "UniProtKB", "id": "Q9H9B4", "url": "https://www.uniprot.org/uniprotkb/Q9H9B4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SFXN4", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2", "locus": { "chromosome": "26", "start_pos": 39311749, "end_pos": 39328281, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008730", "url": "https://www.ensembl.org/id/ENSBTAG00000008730" } ] } } ], "crossref": [ { "id": "Q3T0M2", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0M2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008730", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508473", "url": "https://www.ncbi.nlm.nih.gov/gene/508473", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508473", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508473", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NVRFWIA", "url": "https://omabrowser.org/oma/group/NVRFWIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0M2", "url": "https://www.orthodb.org/?gene=Q3T0M2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030232", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0M2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPNVRFWITERQSFIQRFLQWTELLDPTNLVLSIEKIEKSRQLLLTNEDASRGDLEDKRIQEAWKRSLSTVHPDNSRLIPGPFRPAALLPFTAPTLFLSMLPVKSLKSMILPQASFYTYSTAFNIVNGNASYDRRAHESLLLGAGVIVSSTFLGLFPRLLQVRLSMNSVLSRNFIPVIILAQLSGMNVIASRSLEPMRGIEVMDKEGNVIGYSRKAGTKAVKDTATSRVVLFGTSAFIPEVFAYFFKRTQFFLQNPWSLWTLKLSCTVLVMGLMVPVSFSVFPQIGRIQCNELEKEIQSATEETELFYNRGV", "length": 313, "header": "sp|Q3T0M2-1|SFXN4_BOVIN Isoform 1 of Sideroflexin-4 OS=Bos taurus OX=9913 GN=SFXN4 PE=2 SV=1 CANONICAL=Q3T0M2-1" }, "isoforms": [ { "isoform_ac": "Q3T0M2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2/entry#Q3T0M2-1", "sequence": { "sequence": "MEPNVRFWITERQSFIQRFLQWTELLDPTNLVLSIEKIEKSRQLLLTNEDASRGDLEDKRIQEAWKRSLSTVHPDNSRLIPGPFRPAALLPFTAPTLFLSMLPVKSLKSMILPQASFYTYSTAFNIVNGNASYDRRAHESLLLGAGVIVSSTFLGLFPRLLQVRLSMNSVLSRNFIPVIILAQLSGMNVIASRSLEPMRGIEVMDKEGNVIGYSRKAGTKAVKDTATSRVVLFGTSAFIPEVFAYFFKRTQFFLQNPWSLWTLKLSCTVLVMGLMVPVSFSVFPQIGRIQCNELEKEIQSATEETELFYNRGV", "length": 313, "header": "sp|Q3T0M2-1|SFXN4_BOVIN Isoform 1 of Sideroflexin-4 OS=Bos taurus OX=9913 GN=SFXN4 PE=2 SV=1 CANONICAL=Q3T0M2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508473", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508473", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKL2-1", "protein_name": "Sideroflexin 4", "gene_name": "SFXN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPNVRFWITERQSFIQRFLQWTELLDPTNLVISIEKIEKSRQLLLTNEDASRGDLEDKRIQEAWKRSLSTVHPDNSKLIPSPFRPAALLPFTAPMVFLSMLPVKKLKSMILPQVSFYTYSTIFNLVNGNASYDRRPHESVLLGAGVIASSTFFGLLPRLLQVKFSLSTVLSRNVIPVLVLAQLSGMNVVASRSLEPMRGIEVMDKEGNVIGYSRKAGAKAIKDTATSRVVLFGSSAFIPEVFSYFFKRTQFFLQCPWSLWTLKLSCTILVMGLMVPVSFSVFPQIGRIQCSELEKEIQSATEETELFYNRGV", "length": 313 }, "evidence": [ { "id": "Q3T0M2", "url": "https://omabrowser.org/oma/group/Q3T0M2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A8E7G5-1", "protein_name": "Sideroflexin-4", "gene_name": "sfxn4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPNLQYWQNNGQSFLSRLGLWSKILDPTLLLSQAEIEEARTLIQNEENTPGKNDKVSNAWLLSLSSVHSDTGAVISPAYRPQVFLPISAPLVVGSLIAHKGIKSAMFWQFVLHTYCAGFNHANRNATATKDNKTTMKQSLLILGAVSYSTVTGALPQIILQRLRLISSLTQTICRSFLPVPLAAGLAAFNILVVRSEEAENGISLFDANGNAVGVSKEAGFKAVKETAISRATLFGTTAALPTFLMALLERAKFVQRNPRLIAPIGSMCTVITFGLMIPVSFSLFPQLGKIKKENLEKEFQSLDGNEELFYHRGL", "length": 316 }, "evidence": [ { "id": "Q3T0M2", "url": "https://omabrowser.org/oma/group/Q3T0M2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P4A7-1", "protein_name": "Sideroflexin-4", "gene_name": "SFXN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV", "length": 337 }, "evidence": [ { "id": "Q3T0M2", "url": "https://omabrowser.org/oma/group/Q3T0M2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q925N1-1", "protein_name": "Sideroflexin-4", "gene_name": "Sfxn4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPNLQFWISERQAFFRRFCQWMDLLDPVNMFISIGSIEKSRQLLFTTEDAPKHYLDNQVIKDAWNKSLSTVHPDSSKLIPHLFRPAAFLPVTAPMVFLLMMPDTGIKSIILTQGCLYGYTTAFNITNGNASYSHGPVERTLLGAGVSVSSTFIGLIPHLFQMKYPPNNFWLKRTLPIVFLAQVSGMNVFASRSFENHRGIEVMDKEGHVVGHSRKAGRKAIKDTAKSRAVLFGTSALAPELFIHIFKRTRFYPQTLLSLVILRMSSTFFMMGLMVPVSFSMFPQIGQIQCSQLEEKIQSSTEEKELFYYRGV", "length": 313 }, "evidence": [ { "id": "Q3T0M2", "url": "https://omabrowser.org/oma/group/Q3T0M2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" }, { "name": "monoatomic ion transmembrane transporter activity", "id": "GO:0015075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015075", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" }, { "name": "mitochondrial transmembrane transport", "id": "GO:1990542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990542", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M2", "url": "https://www.uniprot.org/uniprotkb/Q3T0M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0M2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0M2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0M2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0M3-1", "uniprot_ac": "Q3T0M3", "uniprot_id": "IMP3_BOVIN", "mass": { "chemical_mass": 21836.0, "monoisotopic_mass": 21836.0 }, "refseq": { "ac": "NP_001073056", "name": "U3 small nucleolar ribonucleoprotein IMP3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" }, "gene_names": [ { "name": "IMP3", "type": "recommended", "evidence": [ { "id": "Q3T0M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ] }, { "name": "BRMS2", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" } ] }, { "name": "IMP3", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" } ] } ], "protein_names": [ { "name": "U3 small nucleolar ribonucleoprotein protein IMP3", "type": "recommended", "evidence": [ { "id": "Q3T0M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3/entry#names_and_taxonomy" } ] }, { "name": "IMP3, U3 small nucleolar ribonucleoprotein, homolog", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" } ] }, { "name": "U3 small nucleolar ribonucleoprotein IMP3", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" } ] }, { "name": "U3 small nucleolar ribonucleoprotein protein IMP3", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" } ] }, { "name": "U3 snoRNP protein IMP3", "type": "synonym", "evidence": [ { "id": "NP_001073056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056" }, { "id": "Q3T0M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3#function" }, { "database": "UniProtKB", "id": "Q9NV31", "url": "https://www.uniprot.org/uniprotkb/Q9NV31#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMP3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3", "locus": { "chromosome": "21", "start_pos": 33273091, "end_pos": 33254352, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069591", "url": "https://www.ensembl.org/id/ENSBTAG00000069591" } ] } } ], "crossref": [ { "id": "Q3T0M3", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0M3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00165", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00165", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511560", "url": "https://www.ncbi.nlm.nih.gov/gene/511560", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511560", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511560", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0M3", "url": "https://www.orthodb.org/?gene=Q3T0M3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11831", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11831", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11831:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11831:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00163", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00163", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01479", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01479", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073056", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0M3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELARRLRDLPERDPFRVRSSAALLDKLYALGLVPTRGSQELCDFVTASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLDA", "length": 184, "header": "sp|Q3T0M3-1|IMP3_BOVIN Isoform 1 of U3 small nucleolar ribonucleoprotein protein IMP3 OS=Bos taurus OX=9913 GN=IMP3 PE=2 SV=1 CANONICAL=Q3T0M3-1" }, "isoforms": [ { "isoform_ac": "Q3T0M3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3/entry#Q3T0M3-1", "sequence": { "sequence": "MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELARRLRDLPERDPFRVRSSAALLDKLYALGLVPTRGSQELCDFVTASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLDA", "length": 184, "header": "sp|Q3T0M3-1|IMP3_BOVIN Isoform 1 of U3 small nucleolar ribonucleoprotein protein IMP3 OS=Bos taurus OX=9913 GN=IMP3 PE=2 SV=1 CANONICAL=Q3T0M3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511560", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511560", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Mpp10 complex", "id": "GO:0034457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034457", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M3", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0M3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0M3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0M3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M3" }, { "id": "PRU00182", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00182" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "S4 RNA-binding", "eco_id": "ECO_0000255", "start_pos": 109, "end_pos": 175, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0T8-1", "uniprot_ac": "Q3T0T8", "uniprot_id": "RGS5_BOVIN", "mass": { "chemical_mass": 20969.0, "monoisotopic_mass": 20969.0 }, "refseq": { "ac": "NP_001029879", "name": "regulator of G-protein signaling 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879" }, "gene_names": [ { "name": "RGS5", "type": "recommended", "evidence": [ { "id": "Q3T0T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ] }, { "name": "RGS5", "type": "synonym", "evidence": [ { "id": "NP_001029879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling 5", "type": "recommended", "evidence": [ { "id": "Q3T0T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8/entry#names_and_taxonomy" } ] }, { "name": "RGS5", "type": "synonym", "evidence": [ { "id": "Q3T0T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling 5", "type": "synonym", "evidence": [ { "id": "NP_001029879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879" } ] } ], "function": [ { "annotation": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8#function" } ] }, { "annotation": "RGS5 was more highly transcribed in ruminal papillae of more efficient low residual feed intake vs. less efficient animals.", "evidence": [ { "database": "RefSeq", "id": "NP_001029879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879" }, { "database": "PubMed", "id": "27611366", "url": "https://glygen.org/publication/PubMed/27611366" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8", "locus": { "chromosome": "3", "start_pos": 6212125, "end_pos": 6159079, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016341", "url": "https://www.ensembl.org/id/ENSBTAG00000016341" } ] } } ], "crossref": [ { "id": "Q3T0T8", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0T8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540509", "url": "https://www.ncbi.nlm.nih.gov/gene/540509", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540509", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540509", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FIIPYPD", "url": "https://omabrowser.org/oma/group/FIIPYPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0T8", "url": "https://www.orthodb.org/?gene=Q3T0T8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NZD2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZD2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0T8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCKGLAALPHSCLERAKEIKIKLGILLQKPESAIDLVIPYNEKPEKPAKTQKPSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWMACEDYKKIKSPVKMAETAKKIYEEFIQVEAPKEVNIDHFTKEITVKNLVEPSPSSFDVAQKRIHALMEKDSLPRFVRSEFYQEFIK", "length": 181, "header": "sp|Q3T0T8-1|RGS5_BOVIN Isoform 1 of Regulator of G protein signaling 5 OS=Bos taurus OX=9913 GN=RGS5 PE=2 SV=1 CANONICAL=Q3T0T8-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NZD2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8/entry#A0ABI0NZD2-1", "sequence": { "sequence": "SMLMQAKEIKIKLGILLQKPESAIDLVIPYNEKPEKPAKTQKPSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWMACEDYKKIKSPVKMAETAKKIYEEFIQVEAPKEVNIDHFTKEITVKNLVEPSPSSFDVAQKRIHALMEKDSLPRFVRSEFYQEFIK", "length": 171, "header": "tr|A0ABI0NZD2-1|A0ABI0NZD2_BOVIN Computationally mapped isoform of Regulator of G protein signaling 5 OS=Bos taurus OX=9913 GN=RGS5 PE=4 SV=1 CANONICAL=Q3T0T8-1" }, "locus": { "chromosome": "3", "start_pos": 6210630, "end_pos": 6188047, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144460.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144460.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107024.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107024.1" } ] } }, { "isoform_ac": "Q3T0T8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8/entry#Q3T0T8-1", "sequence": { "sequence": "MCKGLAALPHSCLERAKEIKIKLGILLQKPESAIDLVIPYNEKPEKPAKTQKPSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWMACEDYKKIKSPVKMAETAKKIYEEFIQVEAPKEVNIDHFTKEITVKNLVEPSPSSFDVAQKRIHALMEKDSLPRFVRSEFYQEFIK", "length": 181, "header": "sp|Q3T0T8-1|RGS5_BOVIN Isoform 1 of Regulator of G protein signaling 5 OS=Bos taurus OX=9913 GN=RGS5 PE=2 SV=1 CANONICAL=Q3T0T8-1" }, "locus": { "chromosome": "3", "start_pos": 6210630, "end_pos": 6159160, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152410.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152410.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107681.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Ruminal expression of the NQO1, RGS5, and ACAT1 genes may be indicators of feed efficiency in beef steers.", "journal": "Animal genetics", "date": "2017-02", "authors": "Kern R J, Zarek C M, Lindholm-Perry A K, Kuehn L A, Snelling W M, Freetly H C, Cunningham H C, Meyer A M", "evidence": [ { "database": "RefSeq", "id": "NP_001029879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029879" } ], "reference": [ { "type": "PubMed", "id": "27611366", "url": "https://glygen.org/publication/PubMed/27611366" } ] } ], "pathway": [ { "id": "bta:540509", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540509", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "O08850-1", "protein_name": "Regulator of G protein signaling 5", "gene_name": "Rgs5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPRSFDLAQKRIYALMEKDSLPRFVRSEFYKELIK", "length": 181 }, "evidence": [ { "id": "Q3T0T8", "url": "https://omabrowser.org/oma/group/Q3T0T8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O15539-1", "protein_name": "Regulator of G protein signaling 5", "gene_name": "RGS5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK", "length": 181 }, "evidence": [ { "id": "Q3T0T8", "url": "https://omabrowser.org/oma/group/Q3T0T8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49800-1", "protein_name": "Regulator of G protein signaling 5", "gene_name": "Rgs5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQSNYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPHSFDLAQKRIYALMEKDSLPRFVRSEFYKELIN", "length": 181 }, "evidence": [ { "id": "Q3T0T8", "url": "https://omabrowser.org/oma/group/Q3T0T8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "R4GKX0-1", "protein_name": "Regulator of G-protein signaling 5", "gene_name": "RGS5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCKGLAALPHTCLERAKEIKTKLGTLLQKPDSAIDFIIPYPEKPEKPAKALKPSPEEVLQWRDSLEKLLQNPYGLASFRSFLCSEFSEENVEFWVACEDYKKTKSPVKMEEKAKRIYEEFIQTEAPKEVNIDHFTKAVTMKNLVEPSPSSFDMAQKRIFALMEKDSLPRFVRSEFYQELIK", "length": 181 }, "evidence": [ { "id": "Q3T0T8", "url": "https://omabrowser.org/oma/group/Q3T0T8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of G protein-coupled receptor signaling pathway", "id": "GO:0045744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045744", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "pmid": "" }, { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T8", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0T8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 181, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0T8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0T8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T8" }, { "id": "PRU00171", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000255", "start_pos": 64, "end_pos": 180, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0Z4-1", "uniprot_ac": "Q3T0Z4", "uniprot_id": "T4S20_BOVIN", "mass": { "chemical_mass": 25214.0, "monoisotopic_mass": 25214.0 }, "refseq": { "ac": "NP_001070449", "name": "transmembrane 4 L6 family member 20", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070449" }, "gene_names": [ { "name": "TM4SF20", "type": "recommended", "evidence": [ { "id": "Q3T0Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4" } ] }, { "name": "TM4SF20", "type": "synonym", "evidence": [ { "id": "NP_001070449", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070449" } ] } ], "protein_names": [ { "name": "Transmembrane 4 L6 family member 20", "type": "recommended", "evidence": [ { "id": "Q3T0Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4/entry#names_and_taxonomy" } ] }, { "name": "transmembrane 4 L6 family member 20", "type": "synonym", "evidence": [ { "id": "NP_001070449", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070449" } ] } ], "function": [ { "annotation": "Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4#function" }, { "database": "UniProtKB", "id": "Q53R12", "url": "https://www.uniprot.org/uniprotkb/Q53R12#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM4SF20", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4", "locus": { "chromosome": "2", "start_pos": 115519318, "end_pos": 115530237, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021322", "url": "https://www.ensembl.org/id/ENSBTAG00000021322" } ] } } ], "crossref": [ { "id": "Q3T0Z4", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0Z4", "database": "AlphaFoldDB", "categories": [] }, { "id": "767902", "url": "https://www.ncbi.nlm.nih.gov/gene/767902", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767902", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767902", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0Z4", "url": "https://www.orthodb.org/?gene=Q3T0Z4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070449", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Z4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCCEGWTSCNGFSLLVLLLLGVTLNAIPLILNFVDEDQFFENPISCFEWWFPGIIGAGVMAIPATTMSLAARKRACCNNKTGMFLSSLLNAITVIGAAYCLLVSIQALAEGPLICNSQSNTTSSCEFSLKNLTANYKESFDLQWFFEDSCVPHTDSNNPSITNTTANNWRVYNLHFNSIENQHRIIHFSVFLGLLLVGILEILFGLSQIIIGFFGCLCGGVSNGRSQIV", "length": 230, "header": "sp|Q3T0Z4-1|T4S20_BOVIN Isoform 1 of Transmembrane 4 L6 family member 20 OS=Bos taurus OX=9913 GN=TM4SF20 PE=2 SV=1 CANONICAL=Q3T0Z4-1" }, "isoforms": [ { "isoform_ac": "Q3T0Z4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4/entry#Q3T0Z4-1", "sequence": { "sequence": "MTCCEGWTSCNGFSLLVLLLLGVTLNAIPLILNFVDEDQFFENPISCFEWWFPGIIGAGVMAIPATTMSLAARKRACCNNKTGMFLSSLLNAITVIGAAYCLLVSIQALAEGPLICNSQSNTTSSCEFSLKNLTANYKESFDLQWFFEDSCVPHTDSNNPSITNTTANNWRVYNLHFNSIENQHRIIHFSVFLGLLLVGILEILFGLSQIIIGFFGCLCGGVSNGRSQIV", "length": 230, "header": "sp|Q3T0Z4-1|T4S20_BOVIN Isoform 1 of Transmembrane 4 L6 family member 20 OS=Bos taurus OX=9913 GN=TM4SF20 PE=2 SV=1 CANONICAL=Q3T0Z4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767902", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767902", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of proteolysis", "id": "GO:0045861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045861", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z4", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Z4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Z4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Z4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0Z5-1", "uniprot_ac": "Q3T0Z5", "uniprot_id": "LENG1_BOVIN", "mass": { "chemical_mass": 30015.0, "monoisotopic_mass": 30015.0 }, "refseq": { "ac": "NP_001029976", "name": "leukocyte receptor cluster member 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029976" }, "gene_names": [ { "name": "LENG1", "type": "recommended", "evidence": [ { "id": "Q3T0Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5" } ] }, { "name": "LENG1", "type": "synonym", "evidence": [ { "id": "NP_001029976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029976" } ] } ], "protein_names": [ { "name": "Leukocyte receptor cluster member 1 homolog", "type": "recommended", "evidence": [ { "id": "Q3T0Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5/entry#names_and_taxonomy" } ] }, { "name": "leukocyte receptor cluster (LRC) member 1", "type": "synonym", "evidence": [ { "id": "NP_001029976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029976" } ] }, { "name": "leukocyte receptor cluster member 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029976" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z5", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LENG1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5", "locus": { "chromosome": "18", "start_pos": 63249596, "end_pos": 63238454, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023333", "url": "https://www.ensembl.org/id/ENSBTAG00000023333" } ] } } ], "crossref": [ { "id": "Q3T0Z5", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023333", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023333", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617891", "url": "https://www.ncbi.nlm.nih.gov/gene/617891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617891", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617891", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WYEELPK", "url": "https://omabrowser.org/oma/group/WYEELPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0Z5", "url": "https://www.orthodb.org/?gene=Q3T0Z5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22093", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22093", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22093:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22093:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10197", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10197", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029976", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0Z5", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Z5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEARAREEEKERERRVLLAQQEARTEFLRKKARHQNWLPALEAAEAGAPGSSGPVDLFRELLEEGKAVTKGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPRQGGPASGPGPDERIKSRLDPLREMQKHLGKKRKHSGDSGGHSTKEKAAPEKQRPKGPPSLEQLRADRLRREAAERARAEALLARVGGTAAPEEQPEEVDERRRRYNSQFNPQLARRPRRQDPPVAP", "length": 263, "header": "sp|Q3T0Z5-1|LENG1_BOVIN Isoform 1 of Leukocyte receptor cluster member 1 homolog OS=Bos taurus OX=9913 GN=LENG1 PE=2 SV=1 CANONICAL=Q3T0Z5-1" }, "isoforms": [ { "isoform_ac": "Q3T0Z5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5/entry#Q3T0Z5-1", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEARAREEEKERERRVLLAQQEARTEFLRKKARHQNWLPALEAAEAGAPGSSGPVDLFRELLEEGKAVTKGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPRQGGPASGPGPDERIKSRLDPLREMQKHLGKKRKHSGDSGGHSTKEKAAPEKQRPKGPPSLEQLRADRLRREAAERARAEALLARVGGTAAPEEQPEEVDERRRRYNSQFNPQLARRPRRQDPPVAP", "length": 263, "header": "sp|Q3T0Z5-1|LENG1_BOVIN Isoform 1 of Leukocyte receptor cluster member 1 homolog OS=Bos taurus OX=9913 GN=LENG1 PE=2 SV=1 CANONICAL=Q3T0Z5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Z5", "url": "https://www.uniprot.org/uniprotkb/Q3T0Z5" } ], "site_lbl": "Ser244" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617891", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617891", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1P8B457-1", "protein_name": "Leukocyte receptor cluster-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGGHGGLNILPQKRWNVYNFDNREKVRKEEEAAAREEQIKREEARKRDAESRLEVLRNVRGLAPLKRASPEAEKGKDEAVVAAAVVKSTAVVVESVESEEPKTGHINLFEGIRIFDPIEIKKNDKPADEEDQRRKKMRKEAAATARASAKDAAARAGDPDEEKYRLGYGVAGKGVKRPWYLEKRNDENDSVRGEDDDGGCGGYEAKKKKMSGKKSLKELREERLKRERVEKERERALFMKQSQRAGGFSRRR", "length": 252 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "D3ZER8-1", "protein_name": "Leukocyte receptor cluster member 1", "gene_name": "Leng1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARGRNSLPELEAADQGAPCSGPVDLFRELLEEGKGVPRGNKEHEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGQKGCPPGPSPDEKIKNRLDPLREMQKHLGKKRHSSESHPSREERPPKQRPREPPSLEKLRAERLQREAAERARAEALLARVQGQVSQQGQVEMEETDERKRRYNSQFNPQLARRPRQQNPTPPH", "length": 260 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RNH2-1", "protein_name": "Leukocyte receptor cluster member 1", "gene_name": "LENG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSLPALEAAEAGAPRSGPVDLFRELLEEGKGLSRGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGQGTPSPGAGRDEKIKNRLDPLREMQKHLGKKRKQSRDDSSHSGKEKEPPVKQWPTEPPSLDRLRAERLRREAAERARAEALLARVRGTAAQEHRPEEEVDERQRRYNSQFNPQLARRPRRQELPPAH", "length": 263 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96BZ8-1", "protein_name": "Leukocyte receptor cluster member 1", "gene_name": "LENG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSLPELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYKEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALLARVQGRALQEGQPEEDETDDRRRRYNSQFNPQLARRPRQQDPHLTH", "length": 264 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DB98-1", "protein_name": "Leukocyte receptor cluster member 1 homolog", "gene_name": "Leng1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARQRNSVPELEAADPGAPSSGPVDLFRELLEERKGVPRGNKEHEEEKRREKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGQKDCCPPGPSPDEKIKNRLDPLKEMQKHLAKKRHSSESRPSREERPQKQRPREPPSLEKLRAERLQREAAERARAEALLARVQGQVSQQGQVEAEETDERRRRYNSQFNPQLARRPRQQNPTPAH", "length": 261 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VH00-1", "protein_name": "CBF1-interacting co-repressor CIR N-terminal domain-containing protein", "gene_name": "Dmel\\CG12818", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNILPKKRWHVRTKENIARVRRDQAAAAAEEKVRQEKLEFAESEARINFLRRQSGLPEKASKESREESQCSTETTKGVDLFADYKARVKTTNKDLEKEQKEEQEKYEKQIGYLTYLGQDTNEALKVRSWYELAPKRPEVGDPTATETHHKQKLAHDPLTLINALLPPEKKDPKKATKRIRERTPAPSQEPSIPHKDKKSKKDKKKHKSKNGSRETLLAEERIKREKLETLRRERMRRETAERQRSEALFAPKELPVAASAESTPASTPKVVQKYNSQFNPELAKQNML", "length": 288 }, "evidence": [ { "id": "Q3T0Z5", "url": "https://omabrowser.org/oma/group/Q3T0Z5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Z5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 244 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T123-1", "uniprot_ac": "Q3T123", "uniprot_id": "MED7_BOVIN", "mass": { "chemical_mass": 27278.0, "monoisotopic_mass": 27278.0 }, "refseq": { "ac": "NP_001073051", "name": "mediator of RNA polymerase II transcription subunit 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" }, "gene_names": [ { "name": "MED7", "type": "recommended", "evidence": [ { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ] }, { "name": "CRSP9", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" }, { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ] }, { "name": "MED7", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 7", "type": "recommended", "evidence": [ { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123/entry#names_and_taxonomy" } ] }, { "name": "CRSP complex subunit 9", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" }, { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123/entry#names_and_taxonomy" } ] }, { "name": "Cofactor required for Sp1 transcriptional activation subunit 9", "type": "synonym", "evidence": [ { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 7", "type": "synonym", "evidence": [ { "id": "Q3T123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T123/entry#names_and_taxonomy" } ] }, { "name": "cofactor required for Sp1 transcriptional activation subunit 9", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" } ] }, { "name": "cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 7", "type": "synonym", "evidence": [ { "id": "NP_001073051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED7", "url": "https://www.uniprot.org/uniprotkb/Q3T123", "locus": { "chromosome": "7", "start_pos": 68815791, "end_pos": 68820060, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050263", "url": "https://www.ensembl.org/id/ENSBTAG00000050263" } ] } } ], "crossref": [ { "id": "Q3T123", "url": "https://alphafold.ebi.ac.uk/entry/Q3T123", "database": "AlphaFoldDB", "categories": [] }, { "id": "509729", "url": "https://www.ncbi.nlm.nih.gov/gene/509729", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509729", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509729", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T123", "url": "https://www.orthodb.org/?gene=Q3T123", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15498", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15498", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15498:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15498:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05983", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05983", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073051", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T123-1", "url": "https://www.uniprot.org/uniprotkb/Q3T123-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDSNNCIGQNEQQRENSGHRRDQIIEKDAALCVLIDEMNERP", "length": 233, "header": "sp|Q3T123-1|MED7_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 7 OS=Bos taurus OX=9913 GN=MED7 PE=2 SV=1 CANONICAL=Q3T123-1" }, "isoforms": [ { "isoform_ac": "Q3T123-1", "url": "https://www.uniprot.org/uniprotkb/Q3T123/entry#Q3T123-1", "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDSNNCIGQNEQQRENSGHRRDQIIEKDAALCVLIDEMNERP", "length": 233, "header": "sp|Q3T123-1|MED7_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 7 OS=Bos taurus OX=9913 GN=MED7 PE=2 SV=1 CANONICAL=Q3T123-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "site_lbl": "Ser194" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509729", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509729", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q3T123", "url": "https://www.uniprot.org/uniprotkb/Q3T123" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T123-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 233, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T123-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T123" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 194 ], "sequon_annotation_sites": [ { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T130-1", "uniprot_ac": "Q3T130", "uniprot_id": "TM45B_BOVIN", "mass": { "chemical_mass": 32206.0, "monoisotopic_mass": 32206.0 }, "refseq": { "ac": "NP_001029547", "name": "transmembrane protein 45B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029547" }, "gene_names": [ { "name": "TMEM45B", "type": "recommended", "evidence": [ { "id": "Q3T130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ] }, { "name": "TMEM45B", "type": "synonym", "evidence": [ { "id": "NP_001029547", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029547" } ] } ], "protein_names": [ { "name": "Transmembrane protein 45B", "type": "recommended", "evidence": [ { "id": "Q3T130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T130/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 45B", "type": "synonym", "evidence": [ { "id": "NP_001029547", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029547" } ] } ], "function": [ { "annotation": "Plays a role in innate immunity. Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity.", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130#function" }, { "database": "UniProtKB", "id": "Q8VCZ2", "url": "https://www.uniprot.org/uniprotkb/Q8VCZ2#function" }, { "database": "UniProtKB", "id": "Q96B21", "url": "https://www.uniprot.org/uniprotkb/Q96B21#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM45B", "url": "https://www.uniprot.org/uniprotkb/Q3T130", "locus": { "chromosome": "29", "start_pos": 36066501, "end_pos": 36040441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017602", "url": "https://www.ensembl.org/id/ENSBTAG00000017602" } ] } } ], "crossref": [ { "id": "Q3T130", "url": "https://alphafold.ebi.ac.uk/entry/Q3T130", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017602", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017602", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510305", "url": "https://www.ncbi.nlm.nih.gov/gene/510305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SWYLSAT", "url": "https://omabrowser.org/oma/group/SWYLSAT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T130", "url": "https://www.orthodb.org/?gene=Q3T130", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16007", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16007", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16007:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16007:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04819", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04819", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029547", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T130-1", "url": "https://www.uniprot.org/uniprotkb/Q3T130-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANFKGHALPGSFFLIVGLWWSLKYPLKYFYQKEKSNQLTHHYQRLEIIEAAIRTLFAVIGILVEQFVPDGPHLHLYHEDHWVKLMNWQHSTMYLFFAVSGIMDMLTYLITHVPLGLDRLVMALAAFNEGFLFYYHVRDRPPLDQHIHSLLLYTVFGGALSLAVEVVLRDNIVLELFRTSLLLLQGTWFWQIGFVLFPPFGGPEWDQNSHDNIMFVTMCFCWHYLAALCILAASYSLVYCFLTRVKRPEDREVIGIQKLRSDHTYRKALLSGSDEE", "length": 276, "header": "sp|Q3T130-1|TM45B_BOVIN Isoform 1 of Transmembrane protein 45B OS=Bos taurus OX=9913 GN=TMEM45B PE=2 SV=1 CANONICAL=Q3T130-1" }, "isoforms": [ { "isoform_ac": "Q3T130-1", "url": "https://www.uniprot.org/uniprotkb/Q3T130/entry#Q3T130-1", "sequence": { "sequence": "MANFKGHALPGSFFLIVGLWWSLKYPLKYFYQKEKSNQLTHHYQRLEIIEAAIRTLFAVIGILVEQFVPDGPHLHLYHEDHWVKLMNWQHSTMYLFFAVSGIMDMLTYLITHVPLGLDRLVMALAAFNEGFLFYYHVRDRPPLDQHIHSLLLYTVFGGALSLAVEVVLRDNIVLELFRTSLLLLQGTWFWQIGFVLFPPFGGPEWDQNSHDNIMFVTMCFCWHYLAALCILAASYSLVYCFLTRVKRPEDREVIGIQKLRSDHTYRKALLSGSDEE", "length": 276, "header": "sp|Q3T130-1|TM45B_BOVIN Isoform 1 of Transmembrane protein 45B OS=Bos taurus OX=9913 GN=TMEM45B PE=2 SV=1 CANONICAL=Q3T130-1" }, "locus": { "chromosome": "29", "start_pos": 36065677, "end_pos": 36061964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140843.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140843.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105588.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105588.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 271, "end_pos": 271, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "site_lbl": "Ser271" }, { "start_pos": 273, "end_pos": 273, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "site_lbl": "Ser273" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q497B2-1", "protein_name": "Transmembrane protein 45B", "gene_name": "Tmem45b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANFKGHALPGSFFLIFGLWWSVKYPLKYFHQKGLKKNRLSLQQQRIEIIEGAVKALFAVIGILAEQFVPDGPHLHLYHENQWTKLMNWQHSTMYLFFGVSGIIDMLTYLYFNIVPLGLDRVVLAMAVFVEGFLFYFHVHGRPPLDQHIHSLLLFSLFGATISICLEVILRDNIVLELFRTTLLILQGTWFWQIGFVLFPPFGTPEWDQKDMDNVMFITMCFCWHYLVALCITAINYSLVYCFLTRVRRRAEGEIIGIQKLKSDHTYQSTLLSGSDEE", "length": 278 }, "evidence": [ { "id": "Q3T130", "url": "https://omabrowser.org/oma/group/Q3T130/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VCZ2-1", "protein_name": "Transmembrane protein 45B", "gene_name": "Tmem45b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANFKGHALPGSFFLIVGLWWSVKYPLKYFHHKGLKNNRLSRQQERIEIIEGAVKTLFAIIGILAEQFVPDGPHLHLYHENQWVKLMNWQHSTMYLFFGVSGLMDMITYLYFHIVPLGLDRVVLAMAVFIEGFLFYFHVHNRPPLDQHIHSLLLFGLFGAAVSISLEVILRDNIVLELFRTSLLILQGTWFWQIGFVLFPPFGRPEWDQKDMDNIMFITMCFCWHYLVALCIVAINYSLVYCFLTRVKRRAEGEIIGIQKLKSDHTYQSALLSGSDEE", "length": 278 }, "evidence": [ { "id": "Q3T130", "url": "https://omabrowser.org/oma/group/Q3T130/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "pmid": "" }, { "name": "response to pain", "id": "GO:0048265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048265", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q3T130", "url": "https://www.uniprot.org/uniprotkb/Q3T130" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T130-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 276, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T130-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T130" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 271, 273 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T134-1", "uniprot_ac": "Q3T134", "uniprot_id": "SPCS1_BOVIN", "mass": { "chemical_mass": 11805.0, "monoisotopic_mass": 11805.0 }, "refseq": { "ac": "NP_001029576", "name": "signal peptidase complex subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" }, "gene_names": [ { "name": "SPCS1", "type": "recommended", "evidence": [ { "id": "Q3T134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T134" } ] }, { "name": "SPCS1", "type": "synonym", "evidence": [ { "id": "NP_001029576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" } ] } ], "protein_names": [ { "name": "Signal peptidase complex subunit 1", "type": "recommended", "evidence": [ { "id": "Q3T134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T134/entry#names_and_taxonomy" } ] }, { "name": "Microsomal signal peptidase 12 kDa subunit", "type": "synonym", "evidence": [ { "id": "Q3T134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T134/entry#names_and_taxonomy" } ] }, { "name": "SPase 12 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001029576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" }, { "id": "Q3T134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T134/entry#names_and_taxonomy" } ] }, { "name": "microsomal signal peptidase 12 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001029576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" } ] }, { "name": "signal peptidase complex subunit 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" } ] }, { "name": "signal peptidase complex subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001029576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576" } ] } ], "function": [ { "annotation": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134#function" }, { "database": "UniProtKB", "id": "Q9Y6A9", "url": "https://www.uniprot.org/uniprotkb/Q9Y6A9#function" }, { "database": "UniProtKB", "id": "P46965", "url": "https://www.uniprot.org/uniprotkb/P46965#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPCS1", "url": "https://www.uniprot.org/uniprotkb/Q3T134", "locus": {} } ], "crossref": [ { "id": "Q3T134", "url": "https://alphafold.ebi.ac.uk/entry/Q3T134", "database": "AlphaFoldDB", "categories": [] }, { "id": "511453", "url": "https://www.ncbi.nlm.nih.gov/gene/511453", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511453", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511453", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T134", "url": "https://www.orthodb.org/?gene=Q3T134", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13202:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13202:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029576", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T134-1", "url": "https://www.uniprot.org/uniprotkb/Q3T134-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYLAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDSSTEDKKPGERKVKRHAKNN", "length": 102, "header": "sp|Q3T134-1|SPCS1_BOVIN Isoform 1 of Signal peptidase complex subunit 1 OS=Bos taurus OX=9913 GN=SPCS1 PE=3 SV=1 CANONICAL=Q3T134-1" }, "isoforms": [ { "isoform_ac": "Q3T134-1", "url": "https://www.uniprot.org/uniprotkb/Q3T134/entry#Q3T134-1", "sequence": { "sequence": "MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYLAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDSSTEDKKPGERKVKRHAKNN", "length": 102, "header": "sp|Q3T134-1|SPCS1_BOVIN Isoform 1 of Signal peptidase complex subunit 1 OS=Bos taurus OX=9913 GN=SPCS1 PE=3 SV=1 CANONICAL=Q3T134-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511453", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511453", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134" } ], "pmid": "" }, { "name": "signal peptide processing", "id": "GO:0006465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006465", "evidence": [ { "database": "UniProtKB", "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "signal peptidase complex", "id": "GO:0005787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005787", "evidence": [ { "database": "UniProtKB", "id": "Q3T134", "url": "https://www.uniprot.org/uniprotkb/Q3T134" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T134-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 102, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T134-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T134" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T142-1", "uniprot_ac": "Q3T142", "uniprot_id": "RM45_BOVIN", "mass": { "chemical_mass": 35143.0, "monoisotopic_mass": 35143.0 }, "refseq": { "ac": "NP_001030272", "name": "large ribosomal subunit protein mL45", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" }, "gene_names": [ { "name": "MRPL45", "type": "recommended", "evidence": [ { "id": "Q3T142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ] }, { "name": "MRPL45", "type": "synonym", "evidence": [ { "id": "NP_001030272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL45", "type": "recommended", "evidence": [ { "id": "Q3T142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T142/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L45, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" }, { "id": "Q3T142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T142/entry#names_and_taxonomy" } ] }, { "name": "L45mt", "type": "synonym", "evidence": [ { "id": "NP_001030272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" }, { "id": "Q3T142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T142/entry#names_and_taxonomy" } ] }, { "name": "MRP-L45", "type": "synonym", "evidence": [ { "id": "NP_001030272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" }, { "id": "Q3T142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T142/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL45", "type": "synonym", "evidence": [ { "id": "NP_001030272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272" } ] } ], "function": [ { "annotation": "Component of the mitochondrial large ribosomal subunit (mt-LSU). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunnel exit and position the exit at a distance from the membrane surface.", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142#function" }, { "database": "UniProtKB", "id": "Q9BRJ2", "url": "https://www.uniprot.org/uniprotkb/Q9BRJ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL45", "url": "https://www.uniprot.org/uniprotkb/Q3T142", "locus": { "chromosome": "19", "start_pos": 38985580, "end_pos": 38966306, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025001", "url": "https://www.ensembl.org/id/ENSBTAG00000025001" } ] } } ], "crossref": [ { "id": "Q3T142", "url": "https://alphafold.ebi.ac.uk/entry/Q3T142", "database": "AlphaFoldDB", "categories": [] }, { "id": "511479", "url": "https://www.ncbi.nlm.nih.gov/gene/511479", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T142", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T142*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR007379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511479", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511479", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T142", "url": "https://www.orthodb.org/?gene=Q3T142", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28554", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28554", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28554:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28554:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030272", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T142-1", "url": "https://www.uniprot.org/uniprotkb/Q3T142-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPLPRSLSCLSRAVGWWSRQPILMTQSTAVVPVRTKKRFTPPIYQPKYKTEKEFTEYARKAGLVIPQESLERPIHLACTASIFDAYVPPEGDARVSSLSKEGLAQRTERLKKNVASQLSIRRIKESDPNFKVKDFPEKAQDIFIEAHLCLNNSDHDRLHTLVTENCFPDMVWDIKYKTVSWSFVESLEPPQVVQVRCSSLVTKSNTYGQVTVRMHTRQTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLANPYGSWRMHGKIVPPWAPPKQPILKTVMIPGPQLKPGEEYEELQREAHKPQLA", "length": 306, "header": "sp|Q3T142-1|RM45_BOVIN Isoform 1 of Large ribosomal subunit protein mL45 OS=Bos taurus OX=9913 GN=MRPL45 PE=2 SV=1 CANONICAL=Q3T142-1" }, "isoforms": [ { "isoform_ac": "Q3T142-1", "url": "https://www.uniprot.org/uniprotkb/Q3T142/entry#Q3T142-1", "sequence": { "sequence": "MAAPLPRSLSCLSRAVGWWSRQPILMTQSTAVVPVRTKKRFTPPIYQPKYKTEKEFTEYARKAGLVIPQESLERPIHLACTASIFDAYVPPEGDARVSSLSKEGLAQRTERLKKNVASQLSIRRIKESDPNFKVKDFPEKAQDIFIEAHLCLNNSDHDRLHTLVTENCFPDMVWDIKYKTVSWSFVESLEPPQVVQVRCSSLVTKSNTYGQVTVRMHTRQTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLANPYGSWRMHGKIVPPWAPPKQPILKTVMIPGPQLKPGEEYEELQREAHKPQLA", "length": 306, "header": "sp|Q3T142-1|RM45_BOVIN Isoform 1 of Large ribosomal subunit protein mL45 OS=Bos taurus OX=9913 GN=MRPL45 PE=2 SV=1 CANONICAL=Q3T142-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511479", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511479", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q3T142", "url": "https://www.uniprot.org/uniprotkb/Q3T142" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T142-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T142-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T142" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T166-1", "uniprot_ac": "Q3T166", "uniprot_id": "MPTX_BOVIN", "mass": { "chemical_mass": 24702.0, "monoisotopic_mass": 24702.0 }, "refseq": { "ac": "NP_001029399", "name": "mucosal pentraxin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" }, "gene_names": [ { "name": "MPTX", "type": "recommended", "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ] }, { "name": "MPTX1", "type": "synonym", "evidence": [ { "id": "NP_001029399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" } ] }, { "name": "MPTX", "type": "synonym", "evidence": [ { "id": "NP_001029399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" } ] } ], "protein_names": [ { "name": "Mucosal pentraxin", "type": "recommended", "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166/entry#names_and_taxonomy" } ] }, { "name": "mucosal pentraxin precursor", "type": "synonym", "evidence": [ { "id": "NP_001029399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" } ] }, { "name": "mucosal pentraxin", "type": "synonym", "evidence": [ { "id": "NP_001029399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" } ] }, { "name": "putative mucosal pentraxin homolog", "type": "synonym", "evidence": [ { "id": "NP_001029399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPTX", "url": "https://www.uniprot.org/uniprotkb/Q3T166", "locus": {} } ], "crossref": [ { "id": "Q3T166", "url": "https://alphafold.ebi.ac.uk/entry/Q3T166", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012884", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012884", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00152", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00152", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504879", "url": "https://www.ncbi.nlm.nih.gov/gene/504879", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504879", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504879", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SEPSWEQ", "url": "https://omabrowser.org/oma/group/SEPSWEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T166", "url": "https://www.orthodb.org/?gene=Q3T166", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45869:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45869:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00354", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00354", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029399", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T166-1", "url": "https://www.uniprot.org/uniprotkb/Q3T166-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKLLLGVLLLAFLPEGMTQKDLRGKVFIFPEQSDTAYVTLIPRVRKPLRSFTLCLKAFTDLTRPYSLFSYSTKSKDNELLLFVNKVGEYELHIGNTKVTFKVPRPPYGPVHLCVSWESVSGIAELWMNSRPVGRKGLRRGYTLGQDARIILGQEQDSFGGKFDAKQSFVGEIWDVSLWDHVVSLKNLCFTCYTSNILNWKALIYQAKGYVVVKPKL", "length": 217, "header": "sp|Q3T166-1|MPTX_BOVIN Isoform 1 of Mucosal pentraxin OS=Bos taurus OX=9913 GN=MPTX PE=2 SV=1 CANONICAL=Q3T166-1" }, "isoforms": [ { "isoform_ac": "Q3T166-1", "url": "https://www.uniprot.org/uniprotkb/Q3T166/entry#Q3T166-1", "sequence": { "sequence": "MEKLLLGVLLLAFLPEGMTQKDLRGKVFIFPEQSDTAYVTLIPRVRKPLRSFTLCLKAFTDLTRPYSLFSYSTKSKDNELLLFVNKVGEYELHIGNTKVTFKVPRPPYGPVHLCVSWESVSGIAELWMNSRPVGRKGLRRGYTLGQDARIILGQEQDSFGGKFDAKQSFVGEIWDVSLWDHVVSLKNLCFTCYTSNILNWKALIYQAKGYVVVKPKL", "length": 217, "header": "sp|Q3T166-1|MPTX_BOVIN Isoform 1 of Mucosal pentraxin OS=Bos taurus OX=9913 GN=MPTX PE=2 SV=1 CANONICAL=Q3T166-1" }, "locus": { "chromosome": "3", "start_pos": 10462085, "end_pos": 10458870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017120.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017120.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017120.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017120.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504879", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504879", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "pmid": "" }, { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "pmid": "" }, { "name": "complement component C1q complex binding", "id": "GO:0001849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001849", "evidence": [ { "database": "UniProtKB", "id": "Q3T166", "url": "https://www.uniprot.org/uniprotkb/Q3T166" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T166-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T166-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T166" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pentraxin (PTX)", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 217, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 155, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 155, "end_pos": 155, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 156, "amino_acid": "Gln", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 156, "end_pos": 156, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 157, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 157, "end_pos": 157, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 167, "amino_acid": "Gln", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 167, "end_pos": 167, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 77, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 77, "end_pos": 77, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166#function" }, { "id": "Q3T166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T166" }, { "id": "PRU01172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01172" } ], "binding_site_uniprot": 78, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 78, "end_pos": 78, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T171-1", "uniprot_ac": "Q3T171", "uniprot_id": "RL36_BOVIN", "mass": { "chemical_mass": 12224.0, "monoisotopic_mass": 12224.0 }, "refseq": { "ac": "NP_001071607", "name": "large ribosomal subunit protein eL36", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" }, "gene_names": [ { "name": "RPL36", "type": "recommended", "evidence": [ { "id": "Q3T171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T171" } ] }, { "name": "RPL35", "type": "synonym", "evidence": [ { "id": "NP_001071607", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" } ] }, { "name": "RPL36", "type": "synonym", "evidence": [ { "id": "NP_001071607", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL36", "type": "recommended", "evidence": [ { "id": "Q3T171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T171/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L36", "type": "synonym", "evidence": [ { "id": "NP_001071607", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" }, { "id": "Q3T171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T171/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL36", "type": "synonym", "evidence": [ { "id": "NP_001071607", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" } ] }, { "name": "ribosomal protein L35", "type": "synonym", "evidence": [ { "id": "NP_001071607", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171#function" }, { "database": "UniProtKB", "id": "Q9Y3U8", "url": "https://www.uniprot.org/uniprotkb/Q9Y3U8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL36", "url": "https://www.uniprot.org/uniprotkb/Q3T171", "locus": {} } ], "crossref": [ { "id": "Q3T171", "url": "https://alphafold.ebi.ac.uk/entry/Q3T171", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001794", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001794", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768327", "url": "https://www.ncbi.nlm.nih.gov/gene/768327", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768327", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768327", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NKGHKTE", "url": "https://omabrowser.org/oma/group/NKGHKTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T171", "url": "https://www.orthodb.org/?gene=Q3T171", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01158", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01158", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001071607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071607", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T171-1", "url": "https://www.uniprot.org/uniprotkb/Q3T171-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRYPMAVGLNKGHKVTKNVGKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD", "length": 105, "header": "sp|Q3T171-1|RL36_BOVIN Isoform 1 of Large ribosomal subunit protein eL36 OS=Bos taurus OX=9913 GN=RPL36 PE=3 SV=3 CANONICAL=Q3T171-1" }, "isoforms": [ { "isoform_ac": "Q3T171-1", "url": "https://www.uniprot.org/uniprotkb/Q3T171/entry#Q3T171-1", "sequence": { "sequence": "MALRYPMAVGLNKGHKVTKNVGKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD", "length": 105, "header": "sp|Q3T171-1|RL36_BOVIN Isoform 1 of Large ribosomal subunit protein eL36 OS=Bos taurus OX=9913 GN=RPL36 PE=3 SV=3 CANONICAL=Q3T171-1" }, "locus": { "chromosome": "7", "start_pos": 18610007, "end_pos": 18608992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075433.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075433.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071600.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071600.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768327", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768327", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "C0HME6-1", "protein_name": "RPL36 alternative reading frame protein", "gene_name": "RPL36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEAEGAGTRGSGPRELSRYSPPPLLPVAVRSHGPTLPYGRGPQQGPQSDQEREQAQAQPTPRASDQTHQVRAGHDSGGVWLCPVRAARHGVTEGLQGQTGPQIYQEKGGDAHPRQEEAGGAEQRTGRHEESCCQERLSPSPALSLK", "length": 148 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZZ95-1", "protein_name": "60S ribosomal protein L36", "gene_name": "Rpl36l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRYPMAVGLNKGHKVTKNVSKPRHSRRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD", "length": 106 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O14455-1", "protein_name": "Large ribosomal subunit protein eL36B", "gene_name": "RPL36B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAVKTGIAIGLNKGKKVTQMTPAPKISYKKGAASNRTKFVRSLVREIAGLSPYERRLIDLIRNSGEKRARKVAKKRLGSFTRAKAKVEEMNNIIAASRRH", "length": 100 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P47964-1", "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "Rpl36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD", "length": 105 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49630-1", "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "RpL36", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAVRYELAIGLNKGHKTSKIRNVKYTGDKKVKGLRGSRLKNIQTRHTKFMRDLVREVVGHAPYEKRTMELLKVSKDKRALKFLKRRLGTHIRAKRKREELSNILTQLRKAQTHAK", "length": 115 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q55AQ9-1", "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "rpl36", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSAATKPVKRSGIIKGFNKGHAVAKRTVTSTFKKQVVTKRVAAIRDVIREISGFSPYERRVSELLKSGLDKRALKVAKKRLGSIQAGKKKRDDIANINRKASAK", "length": 105 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6Q415-1", "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "rpl36", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVVRYPMAVGLNKGHKVTKNVSKPKHSRRRGRLTKHAKFARDLIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNTLAAMRKAAAKKE", "length": 105 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q98TF6-1", "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "RPL36", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAIRYPMAVGLNKGYKVTKNVSKPRHCRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD", "length": 105 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9M352-1", "protein_name": "Large ribosomal subunit protein eL36y", "gene_name": "RPL36B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTTPQVKTGLFVGLNKGHVVTRRELAPRPRSRKGKTSKRTIFIRNLIKEVAGQAPYEKRITELLKVGKDKRALKVAKRKLGTHKRAKRKREEMSSVLRKMRSGGGGATEKKK", "length": 112 }, "evidence": [ { "id": "Q3T171", "url": "https://omabrowser.org/oma/group/Q3T171/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q3T171", "url": "https://www.uniprot.org/uniprotkb/Q3T171" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T171-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 105, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T171-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T171" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T186-1", "uniprot_ac": "Q3T186", "uniprot_id": "RPIA_BOVIN", "mass": { "chemical_mass": 28753.0, "monoisotopic_mass": 28753.0 }, "refseq": {}, "gene_names": [ { "name": "RPIA", "type": "recommended", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ] } ], "protein_names": [ { "name": "Ribose-5-phosphate isomerase", "type": "recommended", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186/entry#names_and_taxonomy" } ] }, { "name": "5.3.1.6", "type": "synonym", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186/entry#names_and_taxonomy" } ] }, { "name": "Phosphoriboisomerase", "type": "synonym", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPIA", "url": "https://www.uniprot.org/uniprotkb/Q3T186", "locus": { "chromosome": "11", "start_pos": 47351604, "end_pos": 47386164, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002866", "url": "https://www.ensembl.org/id/ENSBTAG00000002866" } ] } } ], "crossref": [ { "id": "Q3T186", "url": "https://alphafold.ebi.ac.uk/entry/Q3T186", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01398", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01398", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613376", "url": "https://www.ncbi.nlm.nih.gov/gene/613376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T186", "url": "https://www.orthodb.org/?gene=Q3T186", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11934:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11934:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030510", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14657", "url": "https://www.rhea-db.org/rhea/14657", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T186-1", "url": "https://www.uniprot.org/uniprotkb/Q3T186-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LPGRSQFGAGSTSTGVRETNIVCPGPSAMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVEQENLKLVCIPTSFQARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGNASRFIVIADFRKDSKNLGDQWHKGIPIEVIPMAYVPVSRTVTQKFGGVIELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNIAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPF", "length": 264, "header": "sp|Q3T186-1|RPIA_BOVIN Isoform 1 of Ribose-5-phosphate isomerase OS=Bos taurus OX=9913 GN=RPIA PE=2 SV=2 CANONICAL=Q3T186-1" }, "isoforms": [ { "isoform_ac": "Q3T186-1", "url": "https://www.uniprot.org/uniprotkb/Q3T186/entry#Q3T186-1", "sequence": { "sequence": "LPGRSQFGAGSTSTGVRETNIVCPGPSAMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVEQENLKLVCIPTSFQARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGNASRFIVIADFRKDSKNLGDQWHKGIPIEVIPMAYVPVSRTVTQKFGGVIELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNIAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPF", "length": 264, "header": "sp|Q3T186-1|RPIA_BOVIN Isoform 1 of Ribose-5-phosphate isomerase OS=Bos taurus OX=9913 GN=RPIA PE=2 SV=2 CANONICAL=Q3T186-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "site_lbl": "Ser60" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:613376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613376", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribose-5-phosphate isomerase activity", "id": "GO:0004751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004751", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "D-ribose metabolic process", "id": "GO:0006014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006014", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "pmid": "" }, { "name": "pentose-phosphate shunt, non-oxidative branch", "id": "GO:0009052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009052", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T186", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14657", "name": "", "equation": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T186-1", "G5E534-1" ], "evidence": [ { "id": "14657", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14657" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "G5E534", "gene_name": "RPIA", "activity": [ { "ec_number": "5.3.1.6", "activity": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.", "evidence": [ { "id": "G5E534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E534" } ] }, { "ec_number": "5.3.1.6", "activity": "", "evidence": [ { "id": "G5E534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E534" } ] } ] }, { "uniprot_ac": "Q3T186", "gene_name": "RPIA", "activity": [ { "ec_number": "5.3.1.6", "activity": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ] }, { "ec_number": "5.3.1.6", "activity": "", "evidence": [ { "id": "Q3T186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T186" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T186-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T186-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T186" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.3.1.6", "ec_name": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.", "evidence": [ { "id": "5.3.1.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.6" }, { "id": "5.3.1.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.1.6" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 60 ], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBD4-1", "uniprot_ac": "Q3ZBD4", "uniprot_id": "SMPX_BOVIN", "mass": { "chemical_mass": 9300.0, "monoisotopic_mass": 9300.0 }, "refseq": { "ac": "NP_001032715", "name": "small muscular protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032715" }, "gene_names": [ { "name": "SMPX", "type": "recommended", "evidence": [ { "id": "Q3ZBD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4" } ] }, { "name": "SMPX", "type": "synonym", "evidence": [ { "id": "NP_001032715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032715" } ] } ], "protein_names": [ { "name": "Small muscular protein", "type": "recommended", "evidence": [ { "id": "Q3ZBD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4/entry#names_and_taxonomy" } ] }, { "name": "small muscular protein", "type": "synonym", "evidence": [ { "id": "NP_001032715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032715" } ] } ], "function": [ { "annotation": "Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMPX", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4", "locus": { "chromosome": "X", "start_pos": 121581650, "end_pos": 121528445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015204", "url": "https://www.ensembl.org/id/ENSBTAG00000015204" } ] } } ], "crossref": [ { "id": "Q3ZBD4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015204", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015204", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615975", "url": "https://www.ncbi.nlm.nih.gov/gene/615975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615975", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPRKKEC", "url": "https://omabrowser.org/oma/group/PPRKKEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBD4", "url": "https://www.orthodb.org/?gene=Q3ZBD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17416:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17416:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032715", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBD4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEIEEGAPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ", "length": 86, "header": "sp|Q3ZBD4-1|SMPX_BOVIN Isoform 1 of Small muscular protein OS=Bos taurus OX=9913 GN=SMPX PE=3 SV=1 CANONICAL=Q3ZBD4-1" }, "isoforms": [ { "isoform_ac": "Q3ZBD4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4/entry#Q3ZBD4-1", "sequence": { "sequence": "MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEIEEGAPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ", "length": 86, "header": "sp|Q3ZBD4-1|SMPX_BOVIN Isoform 1 of Small muscular protein OS=Bos taurus OX=9913 GN=SMPX PE=3 SV=1 CANONICAL=Q3ZBD4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615975", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615975", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NJ53-1", "protein_name": "Small muscular protein", "gene_name": "SMPX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSKQPASHVKAIQANINIPMGAFRPGAGHPHKRKEVTPEEVEESVPATEEEKDKKHLPGARKLPGPAVNLSEIQNIKSELKFVPKAEQ", "length": 88 }, "evidence": [ { "id": "Q3ZBD4", "url": "https://omabrowser.org/oma/group/Q3ZBD4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q0MUU2-1", "protein_name": "Small muscular protein", "gene_name": "SMPX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRKKECTPETEEAVLPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPRAEQ", "length": 86 }, "evidence": [ { "id": "Q3ZBD4", "url": "https://omabrowser.org/oma/group/Q3ZBD4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q925F0-1", "protein_name": "Small muscular protein", "gene_name": "Smpx", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKQPISNVRSIQANINIPMGAFRPGAGQPPRRKESTPGTAEGAPATPEEKKPVPGMKKFPGPVVNLSEIQNVKSELKYVPKGEQ", "length": 85 }, "evidence": [ { "id": "Q3ZBD4", "url": "https://omabrowser.org/oma/group/Q3ZBD4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DC77-1", "protein_name": "Small muscular protein", "gene_name": "Smpx", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGAPTTSEEKKPIPGMKKFPGPVVNLSEIQNVKSELKFVPKGEQ", "length": 85 }, "evidence": [ { "id": "Q3ZBD4", "url": "https://omabrowser.org/oma/group/Q3ZBD4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHP9-1", "protein_name": "Small muscular protein", "gene_name": "SMPX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEVEEGVPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ", "length": 88 }, "evidence": [ { "id": "Q3ZBD4", "url": "https://omabrowser.org/oma/group/Q3ZBD4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4" } ], "pmid": "" }, { "name": "costamere", "id": "GO:0043034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043034", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4" } ], "pmid": "" }, { "name": "muscle tendon junction", "id": "GO:0005927", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005927", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 86, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBD4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBG5-1", "uniprot_ac": "Q3ZBG5", "uniprot_id": "BAG2_BOVIN", "mass": { "chemical_mass": 23649.0, "monoisotopic_mass": 23649.0 }, "refseq": { "ac": "NP_001029436", "name": "BAG family molecular chaperone regulator 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" }, "gene_names": [ { "name": "BAG2", "type": "recommended", "evidence": [ { "id": "Q3ZBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ] }, { "name": "BAG2", "type": "synonym", "evidence": [ { "id": "NP_001029436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" } ] } ], "protein_names": [ { "name": "BAG family molecular chaperone regulator 2", "type": "recommended", "evidence": [ { "id": "Q3ZBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5/entry#names_and_taxonomy" } ] }, { "name": "BAG family molecular chaperone regulator 2", "type": "synonym", "evidence": [ { "id": "NP_001029436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" } ] }, { "name": "BAG-2", "type": "synonym", "evidence": [ { "id": "NP_001029436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" }, { "id": "Q3ZBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5/entry#names_and_taxonomy" } ] }, { "name": "BCL2 associated athanogene 2", "type": "synonym", "evidence": [ { "id": "NP_001029436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" } ] }, { "name": "Bcl-2-associated athanogene 2", "type": "synonym", "evidence": [ { "id": "Q3ZBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5/entry#names_and_taxonomy" } ] }, { "name": "bcl-2-associated athanogene 2", "type": "synonym", "evidence": [ { "id": "NP_001029436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436" } ] } ], "function": [ { "annotation": "Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5#function" }, { "database": "UniProtKB", "id": "O95816", "url": "https://www.uniprot.org/uniprotkb/O95816#function" }, { "database": "UniProtKB", "id": "A0ABI0P1G6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G6#function" }, { "database": "UniProtKB", "id": "ARBA00053545", "url": "https://www.uniprot.org/uniprotkb/ARBA00053545#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BAG2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5", "locus": {} } ], "crossref": [ { "id": "Q3ZBG5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506107", "url": "https://www.ncbi.nlm.nih.gov/gene/506107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LHATKMI", "url": "https://omabrowser.org/oma/group/LHATKMI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBG5", "url": "https://www.orthodb.org/?gene=Q3ZBG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12334:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12334:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029436", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P1G6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1G6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBG5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQARISAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEVLLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRSPQQQESLKHATRIIDEVVSKFLDDLGNARSHLMSLYSACSSEVPAGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENADKAIKLLEHSKGAASKTLQQNAEARFN", "length": 211, "header": "sp|Q3ZBG5-1|BAG2_BOVIN Isoform 1 of BAG family molecular chaperone regulator 2 OS=Bos taurus OX=9913 GN=BAG2 PE=2 SV=1 CANONICAL=Q3ZBG5-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P1G6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5/entry#A0ABI0P1G6-1", "sequence": { "sequence": "MAQARISAKANEGRFCRSSSMADRSSRLLESLDQLELRGGFWMDEDMSMRKVKEVEALREAATAVEQEKEVLLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRSPQQQESLKHATRIIDEVVSKFLDDLGNARSHLMSLYSACSSEVPAGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENADKAIKLLEHSKGAASKTLQQNAEARFN", "length": 227, "header": "tr|A0ABI0P1G6-1|A0ABI0P1G6_BOVIN Computationally mapped isoform of BAG family molecular chaperone regulator 2 OS=Bos taurus OX=9913 GN=BAG2 PE=4 SV=1 CANONICAL=Q3ZBG5-1" }, "locus": { "chromosome": "23", "start_pos": 3050695, "end_pos": 3041841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152931.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152931.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106513.1" } ] } }, { "isoform_ac": "Q3ZBG5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5/entry#Q3ZBG5-1", "sequence": { "sequence": "MAQARISAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEVLLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRSPQQQESLKHATRIIDEVVSKFLDDLGNARSHLMSLYSACSSEVPAGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENADKAIKLLEHSKGAASKTLQQNAEARFN", "length": 211, "header": "sp|Q3ZBG5-1|BAG2_BOVIN Isoform 1 of BAG family molecular chaperone regulator 2 OS=Bos taurus OX=9913 GN=BAG2 PE=2 SV=1 CANONICAL=Q3ZBG5-1" }, "locus": { "chromosome": "23", "start_pos": 3050695, "end_pos": 3041841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106334.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "site_lbl": "Ser20" }, { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "site_lbl": "Ser31" }, { "start_pos": 73, "end_pos": 73, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "site_lbl": "Ser73" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506107", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AV76-1", "protein_name": "BAG family molecular chaperone regulator 2", "gene_name": "BAG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQARISAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEVLLEMIHSIQNSQDMRQISEGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKQATRIIDEVVSKFLDDLGNAKSHLMSLYSACSSEVPAGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGASKTLQQNTESRFN", "length": 210 }, "evidence": [ { "id": "Q3ZBG5", "url": "https://omabrowser.org/oma/group/Q3ZBG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M1PFF3-1", "protein_name": "BAG family molecular chaperone regulator 2", "gene_name": "bag2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAQAKINAKMNDATKNKFTRTMSMADRSGRLLESLDQIEMRVEALREEASAMEQERECLIEMIQSIQNSQEMRSICDGEREELSLTAARLMGRTLTVKVSLETIRNQQQEEALQKAMKMIDEITEKVLEDLQSARTRLEALHAACVSDAPPVPVDQKFQSVVISCALEDQKKIKRRLETLIRNMDNAEKTIQIMDNPKVDLSKLANGK", "length": 208 }, "evidence": [ { "id": "Q3ZBG5", "url": "https://omabrowser.org/oma/group/Q3ZBG5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O95816-1", "protein_name": "BAG family molecular chaperone regulator 2", "gene_name": "BAG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEVVNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSKTLQQNAESRFN", "length": 211 }, "evidence": [ { "id": "Q3ZBG5", "url": "https://omabrowser.org/oma/group/Q3ZBG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91YN9-1", "protein_name": "BAG family molecular chaperone regulator 2", "gene_name": "Bag2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQAKISAKAHEGRFCRSSSMADRSSRLLESLDQLELRVEALRDAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQEESLKHATRIIDEVVSKFLDDLGNAKSHLMSLYSACSSEVPPGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIDNSDKAIKLLEHAKGAGSKSLQNTDGKFN", "length": 210 }, "evidence": [ { "id": "Q3ZBG5", "url": "https://omabrowser.org/oma/group/Q3ZBG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "R4GL30-1", "protein_name": "BAG cochaperone 2", "gene_name": "BAG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQAKISAKASEGAPPQQQQQQPSAGQLRGRFYRSTSMADRSSRLLENLDQLELRVEAFRDAASAMEQEKETLLEMIHNIQNSQDMRHISEGEREELNLTANRLMGRTLTVEVSVETIRNAQQQESLLHATRMIDEIVNKLLDDLEDAKIRLMSLYGACTSDVPAGPIDQKFQSVVIGCAIEDQKKIKRRLETLLRNLENSEKSITLLEHQKSSMRQSCNTKQD", "length": 224 }, "evidence": [ { "id": "Q3ZBG5", "url": "https://omabrowser.org/oma/group/Q3ZBG5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "pmid": "" }, { "name": "adenyl-nucleotide exchange factor activity", "id": "GO:0000774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000774", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "pmid": "" }, { "name": "positive regulation of proteolysis", "id": "GO:0045862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045862", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBG5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBG5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBG5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG5" }, { "id": "PRU00369", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00369" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAG", "eco_id": "ECO_0000255", "start_pos": 109, "end_pos": 189, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 20, 31, 73 ], "sequon_annotation_sites": [ { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBK8-1", "uniprot_ac": "Q3ZBK8", "uniprot_id": "CENPO_BOVIN", "mass": { "chemical_mass": 33893.0, "monoisotopic_mass": 33893.0 }, "refseq": { "ac": "NP_001070471", "name": "centromere protein O", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070471" }, "gene_names": [ { "name": "CENPO", "type": "recommended", "evidence": [ { "id": "Q3ZBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ] }, { "name": "CENPO", "type": "synonym", "evidence": [ { "id": "NP_001070471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070471" } ] }, { "name": "MCM21R", "type": "synonym", "evidence": [ { "id": "Q3ZBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ] } ], "protein_names": [ { "name": "Centromere protein O", "type": "recommended", "evidence": [ { "id": "Q3ZBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8/entry#names_and_taxonomy" } ] }, { "name": "CENP-O", "type": "synonym", "evidence": [ { "id": "NP_001070471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070471" }, { "id": "Q3ZBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8/entry#names_and_taxonomy" } ] }, { "name": "centromere protein O", "type": "synonym", "evidence": [ { "id": "NP_001070471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070471" } ] } ], "function": [ { "annotation": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPO", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8", "locus": { "chromosome": "11", "start_pos": 74417535, "end_pos": 74433150, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015014", "url": "https://www.ensembl.org/id/ENSBTAG00000015014" } ] } } ], "crossref": [ { "id": "Q3ZBK8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23835", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23835", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23836", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23836", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767930", "url": "https://www.ncbi.nlm.nih.gov/gene/767930", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767930", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767930", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEWANDG", "url": "https://omabrowser.org/oma/group/MEWANDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBK8", "url": "https://www.orthodb.org/?gene=Q3ZBK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14582:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14582:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070471", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELANTLRQDGESRGGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVFTSFAKKGEKLDMSLVS", "length": 296, "header": "sp|Q3ZBK8-1|CENPO_BOVIN Isoform 1 of Centromere protein O OS=Bos taurus OX=9913 GN=CENPO PE=2 SV=1 CANONICAL=Q3ZBK8-1" }, "isoforms": [ { "isoform_ac": "Q3ZBK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8/entry#Q3ZBK8-1", "sequence": { "sequence": "MELANTLRQDGESRGGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVFTSFAKKGEKLDMSLVS", "length": 296, "header": "sp|Q3ZBK8-1|CENPO_BOVIN Isoform 1 of Centromere protein O OS=Bos taurus OX=9913 GN=CENPO PE=2 SV=1 CANONICAL=Q3ZBK8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767930", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767930", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-606279", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FFC5-1", "protein_name": "Centromere protein O", "gene_name": "CENPO", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELANTLSQDGESGGGVLAHLERLETQMSRSHKKLEEPQSAQAVESALGTEIRQLRCLRDKLRAEVRHRQARIKASTASVAPDQTLEMSEQDILKRRQENLKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSIPVFIPLEEIAAKYLQTNIQHFLFILSEYLNAYSGRKFQADRLQSDFAALLAGPLQRNSLCTVLSFTYNVELKGQSFPFGARLLYKDLTITLPTDVSVTHQGMDTLPSTWEEQRAAHESLFFKKPLHQVFTSFARKGDKLDVNLAF", "length": 300 }, "evidence": [ { "id": "Q3ZBK8", "url": "https://omabrowser.org/oma/group/Q3ZBK8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0L5X7-1", "protein_name": "Centromere protein O", "gene_name": "Cenpo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESANSLCPGTECKGGVLAHLERLEAQMNRSNRKSEEPTVREKESSLRTKIRELQQQRDRLRVEVKQWRARIGFLWVALAVLELFSGLKLRDLPRMPGLKVKESSAKEDSSKTTLSEQEVLEKQWRNLKAILQAYRFTGLSGKLTNRRVCVYISTAFEGNLLDSYFVDLAIEKPLRIHHHSIPAFIPLEKIATAYLQTDVQRLLFSLSEYLNAYVGRKYQADQLESDFCAFLTGPLQRSALCNLLSFTYKVEHGTQAFSFSARLLYEDLTAALPTGVTVTRPAGVEASSPHWEEHRASHEMLFRTKTLHQAFASFSKETEMLHLNLVS", "length": 328 }, "evidence": [ { "id": "Q3ZBK8", "url": "https://omabrowser.org/oma/group/Q3ZBK8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K015-1", "protein_name": "Centromere protein O", "gene_name": "Cenpo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESANTLCPGRKCKGGVLAHLERLEAQTNISNRKSEEPAVRKKESSLRTKIRELRQQRDKLRAEVKQWGARVKEPPAKEDPSRTVISEQEVLEREWRNVDAILEAYRFTGLSGKLTSRGVCMCISTAFEGNLLDSYFVDLVIEKPLRIHHHSVPVFIPLEKIAAAHLQTDVQRFLFRLWEYLNAYAGRKYQADQLESDFCDVLTGPLQRNALCNLLSFTYKVEQRCQTFSFSARLLYEDPTAALPTNVTVTRPGVEASSPPWEEHRASHQMLFRTKPLHKVFASFSKETEKLHLNLVS", "length": 298 }, "evidence": [ { "id": "Q3ZBK8", "url": "https://omabrowser.org/oma/group/Q3ZBK8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BU64-1", "protein_name": "Centromere protein O", "gene_name": "CENPO", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRDELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS", "length": 300 }, "evidence": [ { "id": "Q3ZBK8", "url": "https://omabrowser.org/oma/group/Q3ZBK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "kinetochore assembly", "id": "GO:0051382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051382", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ], "pmid": "" }, { "name": "Mis6-Sim4 complex", "id": "GO:0031511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031511", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 296, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBK8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBL9-1", "uniprot_ac": "Q3ZBL9", "uniprot_id": "CCNH_BOVIN", "mass": { "chemical_mass": 37028.0, "monoisotopic_mass": 37028.0 }, "refseq": { "ac": "NP_001073256", "name": "cyclin-H", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073256" }, "gene_names": [ { "name": "CCNH", "type": "recommended", "evidence": [ { "id": "Q3ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ] }, { "name": "CCNH", "type": "synonym", "evidence": [ { "id": "NP_001073256", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073256" } ] } ], "protein_names": [ { "name": "Cyclin-H", "type": "recommended", "evidence": [ { "id": "Q3ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9/entry#names_and_taxonomy" } ] }, { "name": "cyclin-H", "type": "synonym", "evidence": [ { "id": "NP_001073256", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073256" } ] } ], "function": [ { "annotation": "Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). Its expression and activity are constant throughout the cell cycle.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9#function" }, { "database": "UniProtKB", "id": "P51946", "url": "https://www.uniprot.org/uniprotkb/P51946#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNH", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9", "locus": { "chromosome": "7", "start_pos": 87005019, "end_pos": 87067806, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009566", "url": "https://www.ensembl.org/id/ENSBTAG00000009566" } ] } } ], "crossref": [ { "id": "Q3ZBL9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20524", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20524", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20525", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20525", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615512", "url": "https://www.ncbi.nlm.nih.gov/gene/615512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615512", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBL9", "url": "https://www.orthodb.org/?gene=Q3ZBL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16899", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16899", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073256", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBL9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPVFLEPHEEITLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKTLEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPLLENPEILRKTADDFLNRVALTDAHLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTSLSQLLDIMKSMRNLVKKYEPPRPEEVAALKQKLERCHSAELALNVVTKKRKGYEDDDYVSKKSKHEEVCSPKGSFM", "length": 320, "header": "sp|Q3ZBL9-1|CCNH_BOVIN Isoform 1 of Cyclin-H OS=Bos taurus OX=9913 GN=CCNH PE=2 SV=1 CANONICAL=Q3ZBL9-1" }, "isoforms": [ { "isoform_ac": "Q3ZBL9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9/entry#Q3ZBL9-1", "sequence": { "sequence": "MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPVFLEPHEEITLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKTLEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPLLENPEILRKTADDFLNRVALTDAHLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTSLSQLLDIMKSMRNLVKKYEPPRPEEVAALKQKLERCHSAELALNVVTKKRKGYEDDDYVSKKSKHEEVCSPKGSFM", "length": 320, "header": "sp|Q3ZBL9-1|CCNH_BOVIN Isoform 1 of Cyclin-H OS=Bos taurus OX=9913 GN=CCNH PE=2 SV=1 CANONICAL=Q3ZBL9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "site_lbl": "Ser132" }, { "start_pos": 304, "end_pos": 304, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK8", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "site_lbl": "Ser304" }, { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK8", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "site_lbl": "Ser5" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615512", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615512", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" }, { "name": "transcription factor TFIIH holo complex", "id": "GO:0005675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005675", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" }, { "name": "transcription factor TFIIK complex", "id": "GO:0070985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070985", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 320, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 5, 132, 304 ], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBM6-1", "uniprot_ac": "Q3ZBM6", "uniprot_id": "GPAM1_BOVIN", "mass": { "chemical_mass": 30223.0, "monoisotopic_mass": 30223.0 }, "refseq": {}, "gene_names": [ { "name": "GPALPP1", "type": "recommended", "evidence": [ { "id": "Q3ZBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ] } ], "protein_names": [ { "name": "GPALPP motifs-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPALPP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6", "locus": { "chromosome": "12", "start_pos": 15191157, "end_pos": 15157012, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009416", "url": "https://www.ensembl.org/id/ENSBTAG00000009416" } ] } } ], "crossref": [ { "id": "Q3ZBM6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "532698", "url": "https://www.ncbi.nlm.nih.gov/gene/532698", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532698", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532698", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBM6", "url": "https://www.orthodb.org/?gene=Q3ZBM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46370", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46370", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46370:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46370:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12572", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12572", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBM6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKVRGLVCSCISVHVGSILKKNRRQNYSRVLFLSL", "length": 277, "header": "sp|Q3ZBM6-1|GPAM1_BOVIN Isoform 1 of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=2 SV=1 CANONICAL=Q3ZBM6-1" }, "isoforms": [ { "isoform_ac": "Q3ZBM6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6/entry#Q3ZBM6-1", "sequence": { "sequence": "MARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKVRGLVCSCISVHVGSILKKNRRQNYSRVLFLSL", "length": 277, "header": "sp|Q3ZBM6-1|GPAM1_BOVIN Isoform 1 of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=2 SV=1 CANONICAL=Q3ZBM6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser106" }, { "start_pos": 138, "end_pos": 138, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser138" }, { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser143" }, { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Thr147" }, { "start_pos": 149, "end_pos": 149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser149" }, { "start_pos": 150, "end_pos": 150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser150" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM6" } ], "site_lbl": "Ser28" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532698", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532698", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBM6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 277, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBM6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBM6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 28, 106, 138, 143, 147, 149, 150 ], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 268, "end_pos": 270 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBM7-1", "uniprot_ac": "Q3ZBM7", "uniprot_id": "TRPT1_BOVIN", "mass": { "chemical_mass": 27791.0, "monoisotopic_mass": 27791.0 }, "refseq": {}, "gene_names": [ { "name": "TRPT1", "type": "recommended", "evidence": [ { "id": "Q3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ] } ], "protein_names": [ { "name": "tRNA 2'-phosphotransferase 1", "type": "recommended", "evidence": [ { "id": "Q3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.160", "type": "synonym", "evidence": [ { "id": "Q3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPT1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7", "locus": { "chromosome": "29", "start_pos": 42529505, "end_pos": 42534371, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016555", "url": "https://www.ensembl.org/id/ENSBTAG00000016555" } ] } } ], "crossref": [ { "id": "Q3ZBM7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBM7", "url": "https://www.orthodb.org/?gene=Q3ZBM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12684", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12684", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12684:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12684:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "23324", "url": "https://www.rhea-db.org/rhea/23324", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBM7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSFGGRRRETAGPKGRRAHRPPQDQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALADGIPFFRSTNGVILTPGNADGVLPPKYFKEALQLRPTRKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 254, "header": "sp|Q3ZBM7-1|TRPT1_BOVIN Isoform 1 of tRNA 2'-phosphotransferase 1 OS=Bos taurus OX=9913 GN=TRPT1 PE=2 SV=3 CANONICAL=Q3ZBM7-1" }, "isoforms": [ { "isoform_ac": "Q3ZBM7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7/entry#Q3ZBM7-1", "sequence": { "sequence": "MNSFGGRRRETAGPKGRRAHRPPQDQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALADGIPFFRSTNGVILTPGNADGVLPPKYFKEALQLRPTRKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 254, "header": "sp|Q3ZBM7-1|TRPT1_BOVIN Isoform 1 of tRNA 2'-phosphotransferase 1 OS=Bos taurus OX=9913 GN=TRPT1 PE=2 SV=3 CANONICAL=Q3ZBM7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tRNA 2'-phosphotransferase activity", "id": "GO:0000215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000215", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA splicing, via endonucleolytic cleavage and ligation", "id": "GO:0006388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006388", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBM7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23324", "name": "", "equation": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBM7-1", "F1MMI9-1" ], "evidence": [ { "id": "23324", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23324" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MMI9", "gene_name": "TRPT1", "activity": [ { "ec_number": "2.7.1.160", "activity": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide.", "evidence": [ { "id": "F1MMI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ] }, { "ec_number": "2.7.1.160", "activity": "", "evidence": [ { "id": "F1MMI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ] } ] }, { "uniprot_ac": "Q3ZBM7", "gene_name": "TRPT1", "activity": [ { "ec_number": "2.7.1.160", "activity": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide.", "evidence": [ { "id": "Q3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ] }, { "ec_number": "2.7.1.160", "activity": "", "evidence": [ { "id": "Q3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBM7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBM7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBM7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBM7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.160", "ec_name": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide.", "evidence": [ { "id": "2.7.1.160", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.160" }, { "id": "2.7.1.160", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.160" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBN0-1", "uniprot_ac": "Q3ZBN0", "uniprot_id": "ABRAL_BOVIN", "mass": { "chemical_mass": 9047.0, "monoisotopic_mass": 9047.0 }, "refseq": { "ac": "NP_001160033", "name": "costars family protein ABRACL", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033" }, "gene_names": [ { "name": "ABRACL", "type": "recommended", "evidence": [ { "id": "Q3ZBN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0" } ] }, { "name": "ABRACL", "type": "synonym", "evidence": [ { "id": "NP_001160033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033" } ] }, { "name": "C9H6orf115", "type": "synonym", "evidence": [ { "id": "NP_001160033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033" } ] } ], "protein_names": [ { "name": "Costars family protein ABRACL", "type": "recommended", "evidence": [ { "id": "Q3ZBN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0/entry#names_and_taxonomy" } ] }, { "name": "ABRA C-terminal-like protein", "type": "synonym", "evidence": [ { "id": "NP_001160033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033" }, { "id": "Q3ZBN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0/entry#names_and_taxonomy" } ] }, { "name": "costars family protein ABRACL", "type": "synonym", "evidence": [ { "id": "NP_001160033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033" } ] } ], "function": [ { "annotation": "Associates with the actin cytoskeleton and may modulate actin dynamics, in favor of increasing the relative content of F-actin, therefore may play a role in cell migration. May be acting by inhibiting CFL1-mediated actin depolymerization.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0#function" }, { "database": "UniProtKB", "id": "Q9P1F3", "url": "https://www.uniprot.org/uniprotkb/Q9P1F3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABRACL", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0", "locus": { "chromosome": "9", "start_pos": 76774004, "end_pos": 76758381, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001446", "url": "https://www.ensembl.org/id/ENSBTAG00000001446" } ] } } ], "crossref": [ { "id": "Q3ZBN0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001446", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505914", "url": "https://www.ncbi.nlm.nih.gov/gene/505914", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505914", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505914", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QRVHDNV", "url": "https://omabrowser.org/oma/group/QRVHDNV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBN0", "url": "https://www.orthodb.org/?gene=Q3ZBN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46334:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46334:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001160033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160033", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YI84", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNVDHEVKLLVEEIHRLGSKNADGKLSVKFGVLFQDDKCANLFEALVGTLKAAKRRKIITYSGELLLQGVHDDVDIILLQD", "length": 81, "header": "sp|Q3ZBN0-1|ABRAL_BOVIN Isoform 1 of Costars family protein ABRACL OS=Bos taurus OX=9913 GN=ABRACL PE=3 SV=1 CANONICAL=Q3ZBN0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YI84-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0/entry#A0AAF6YI84-1", "sequence": { "sequence": "MNMHLLNVMHIFTLLKSGISSLSLIIKREAAMNVDHEVKLLVEEIHRLGSKNADGKLSVKFGVLFQDDKCANLFEALVGTLKAAKRRKIITYSGELLLQGVHDDVDIILLQD", "length": 112, "header": "tr|A0AAF6YI84-1|A0AAF6YI84_BOVIN Computationally mapped isoform of Costars family protein ABRACL OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3ZBN0-1" }, "locus": { "chromosome": "9", "start_pos": 76773597, "end_pos": 76764159, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001895.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001895.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001895.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001895.5" } ] } }, { "isoform_ac": "Q3ZBN0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0/entry#Q3ZBN0-1", "sequence": { "sequence": "MNVDHEVKLLVEEIHRLGSKNADGKLSVKFGVLFQDDKCANLFEALVGTLKAAKRRKIITYSGELLLQGVHDDVDIILLQD", "length": 81, "header": "sp|Q3ZBN0-1|ABRAL_BOVIN Isoform 1 of Costars family protein ABRACL OS=Bos taurus OX=9913 GN=ABRACL PE=3 SV=1 CANONICAL=Q3ZBN0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505914", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505914", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N6V3-1", "protein_name": "Costars family protein ABRACL", "gene_name": "Abracl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFQDDRCANLFEALVGTLKAAKRRKIVTYTGELLLQGVHDDVDIVLLQD", "length": 81 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KML4-1", "protein_name": "Costars family protein ABRACL", "gene_name": "Abracl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVEHEVNLLVEEIHRLGSKNADGKLSVKFGVLFQDDRCANLFEALVGTLKAAKRRKIVTYAGELLLQGVHDDVDIVLLQD", "length": 81 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q558Y7-1", "protein_name": "Protein costars", "gene_name": "cosA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDVDHEVKELVKFIKKLGTKGADGKYSVKYGVLFNDDDVANFFEALVGTLKAAKKRGIITFQGEILLQRVHDNVDVILLKDE", "length": 82 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6TGV7-1", "protein_name": "Costars family protein ABRACL", "gene_name": "abracl", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNVEHEVSLLIDEIRRLGSKNADGKTSVKFGVLFNDDQCANLFEALVGTLKAAKRKKVITFDGELLLQGVHDNVDVVLLQD", "length": 81 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8LBN7-1", "protein_name": "Costars family protein At4g33640", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNVDEEIQKLEEEIHRLGSRQTDGSYKVTFGVLFNDDRCANIFEALVGTLRAAKKRKIVAFEGELLLQGVHDKVEITLRPTPPPPQAAAATAASS", "length": 95 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9P1F3-1", "protein_name": "Costars family protein ABRACL", "gene_name": "ABRACL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFRDDKCANLFEALVGTLKAAKRRKIVTYPGELLLQGVHDDVDIILLQD", "length": 81 }, "evidence": [ { "id": "Q3ZBN0", "url": "https://omabrowser.org/oma/group/Q3ZBN0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of actin filament-based process", "id": "GO:0032970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032970", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBN0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 81, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBN0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBN0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBN4-1", "uniprot_ac": "Q3ZBN4", "uniprot_id": "CUED2_BOVIN", "mass": { "chemical_mass": 31532.0, "monoisotopic_mass": 31532.0 }, "refseq": { "ac": "NP_001069205", "name": "CUE domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069205" }, "gene_names": [ { "name": "CUEDC2", "type": "recommended", "evidence": [ { "id": "Q3ZBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ] }, { "name": "CUEDC2", "type": "synonym", "evidence": [ { "id": "NP_001069205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069205" } ] } ], "protein_names": [ { "name": "CUE domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q3ZBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4/entry#names_and_taxonomy" } ] }, { "name": "CUE domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001069205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069205" } ] } ], "function": [ { "annotation": "Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUEDC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4", "locus": { "chromosome": "26", "start_pos": 23046322, "end_pos": 23054141, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002501", "url": "https://www.ensembl.org/id/ENSBTAG00000002501" } ] } } ], "crossref": [ { "id": "Q3ZBN4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002501", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002501", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516091", "url": "https://www.ncbi.nlm.nih.gov/gene/516091", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516091", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516091", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLKPQTE", "url": "https://omabrowser.org/oma/group/CLKPQTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBN4", "url": "https://www.orthodb.org/?gene=Q3ZBN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12493:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12493:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02845", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02845", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27983", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27983", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBN4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELERIVSAALLAFVQTHLPEADLSGLDDVIFSYVLGVLGDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMIQKLSGQLSGARNKENVQPQSSEVQGQVSISPEPLQRPEKLKEETMSSAGDTQDEAAGPEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKQGPPAWDGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQIVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH", "length": 283, "header": "sp|Q3ZBN4-1|CUED2_BOVIN Isoform 1 of CUE domain-containing protein 2 OS=Bos taurus OX=9913 GN=CUEDC2 PE=2 SV=1 CANONICAL=Q3ZBN4-1" }, "isoforms": [ { "isoform_ac": "Q3ZBN4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4/entry#Q3ZBN4-1", "sequence": { "sequence": "MELERIVSAALLAFVQTHLPEADLSGLDDVIFSYVLGVLGDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMIQKLSGQLSGARNKENVQPQSSEVQGQVSISPEPLQRPEKLKEETMSSAGDTQDEAAGPEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKQGPPAWDGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQIVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH", "length": 283, "header": "sp|Q3ZBN4-1|CUED2_BOVIN Isoform 1 of CUE domain-containing protein 2 OS=Bos taurus OX=9913 GN=CUEDC2 PE=2 SV=1 CANONICAL=Q3ZBN4-1" }, "locus": { "chromosome": "26", "start_pos": 23048238, "end_pos": 23046501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003250.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003250.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003250.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003250.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 110, "end_pos": 110, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "site_lbl": "Ser110" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516091", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516091", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L131-1", "protein_name": "CUE domain-containing protein 2", "gene_name": "Cuedc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELERIVSSALFAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFIEMMEAYVPGFAHIHRGIIEDMVQTLSVQLSSARNKETLRRPEKLKEESRPPAATGNTQDEAAAAEEEQPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGKEEGPPGWGGPNQDLPRRLRGPRKEELKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPETEEMKATYINLKPARKYRFH", "length": 267 }, "evidence": [ { "id": "Q3ZBN4", "url": "https://omabrowser.org/oma/group/Q3ZBN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6TLH3-1", "protein_name": "CUE domain-containing protein 2", "gene_name": "cuedc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDLQKIIHDALYDFILSYIPHADLSTLDDVILSYITGVLEDLGSQESVEENFDVEVFVEMLEAYIPGFSDIDSVKVCEMMFNLAAKLTSARDTESGEMKIEEGKFPLSESCDLSLGGSREKTHNLTLQAEGATAQVSESSWDNQEQHLLEMFPKCSVTEARSALSIAKGDMEEAVRLIIEGDVQLKCPPSLSANQGKTVSAEVDQKLKASILEKYMLVDDEEDKKVHRPVTPKDAPKKMVRYHGSQVVTTKGERYHLVKKEEPEDMKKTYVSLKPARKYRFH", "length": 282 }, "evidence": [ { "id": "Q3ZBN4", "url": "https://omabrowser.org/oma/group/Q3ZBN4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CXX9-1", "protein_name": "CUE domain-containing protein 2", "gene_name": "Cuedc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELERIVGSALLTFVQAHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGIIGDMMQKLSVQLSDARNKENLHPQSSCVQGQVPIFPETPRQAEKLEEESRPPAAPGNTLDEAAAAEELPGVDVLLEVFPTCSMEQAQWVLAKARGDLEEAVHMLVEGKEEGPPGWDGPSQDLPRRLRGPQKDDLKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH", "length": 284 }, "evidence": [ { "id": "Q3ZBN4", "url": "https://omabrowser.org/oma/group/Q3ZBN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 283, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBN4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBN4" }, { "id": "PRU00468", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00468" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUE", "eco_id": "ECO_0000255", "start_pos": 141, "end_pos": 184, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 110 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBQ1-1", "uniprot_ac": "Q3ZBQ1", "uniprot_id": "UBTD1_BOVIN", "mass": { "chemical_mass": 26002.0, "monoisotopic_mass": 26002.0 }, "refseq": { "ac": "NP_001029433", "name": "ubiquitin domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029433" }, "gene_names": [ { "name": "UBTD1", "type": "recommended", "evidence": [ { "id": "Q3ZBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1" } ] }, { "name": "UBTD1", "type": "synonym", "evidence": [ { "id": "NP_001029433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029433" } ] } ], "protein_names": [ { "name": "Ubiquitin domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029433" } ] } ], "function": [ { "annotation": "May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBQ1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1#function" }, { "database": "UniProtKB", "id": "Q9HAC8", "url": "https://www.uniprot.org/uniprotkb/Q9HAC8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBQ1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBTD1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1", "locus": { "chromosome": "26", "start_pos": 18760653, "end_pos": 18755901, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012719", "url": "https://www.ensembl.org/id/ENSBTAG00000012719" } ] } } ], "crossref": [ { "id": "Q3ZBQ1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012719", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012719", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17120", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17120", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506002", "url": "https://www.ncbi.nlm.nih.gov/gene/506002", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506002", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506002", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GCMGRYL", "url": "https://omabrowser.org/oma/group/GCMGRYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBQ1", "url": "https://www.orthodb.org/?gene=Q3ZBQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029433", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBQ1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBQ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNCVGRQRRERPTAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227, "header": "sp|Q3ZBQ1-1|UBTD1_BOVIN Isoform 1 of Ubiquitin domain-containing protein 1 OS=Bos taurus OX=9913 GN=UBTD1 PE=2 SV=1 CANONICAL=Q3ZBQ1-1" }, "isoforms": [ { "isoform_ac": "Q3ZBQ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1/entry#Q3ZBQ1-1", "sequence": { "sequence": "MGNCVGRQRRERPTAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227, "header": "sp|Q3ZBQ1-1|UBTD1_BOVIN Isoform 1 of Ubiquitin domain-containing protein 1 OS=Bos taurus OX=9913 GN=UBTD1 PE=2 SV=1 CANONICAL=Q3ZBQ1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 142, "start_aa": "Thr", "end_pos": 142, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr142", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506002", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506002", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GZX3-1", "protein_name": "Ubiquitin domain-containing protein 1 isoform X1", "gene_name": "Ubtd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHSQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227 }, "evidence": [ { "id": "Q3ZBQ1", "url": "https://omabrowser.org/oma/group/Q3ZBQ1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L9P2-1", "protein_name": "Ubiquitin domain containing 1", "gene_name": "UBTD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNCVGRQRRERPTAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESPEPPEPTPSARREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227 }, "evidence": [ { "id": "Q3ZBQ1", "url": "https://omabrowser.org/oma/group/Q3ZBQ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FV8-1", "protein_name": "Ubiquitin domain-containing protein 1", "gene_name": "Ubtd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHSQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227 }, "evidence": [ { "id": "Q3ZBQ1", "url": "https://omabrowser.org/oma/group/Q3ZBQ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91WB7-1", "protein_name": "Ubiquitin domain-containing protein 1", "gene_name": "Ubtd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLNASLPDTVGQLKRQLHSQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227 }, "evidence": [ { "id": "Q3ZBQ1", "url": "https://omabrowser.org/oma/group/Q3ZBQ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HAC8-1", "protein_name": "Ubiquitin domain-containing protein 1", "gene_name": "UBTD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 227 }, "evidence": [ { "id": "Q3ZBQ1", "url": "https://omabrowser.org/oma/group/Q3ZBQ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBQ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 227, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBQ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBQ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ1" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 149, "end_pos": 224, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 142 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBQ4-1", "uniprot_ac": "Q3ZBQ4", "uniprot_id": "SNR25_BOVIN", "mass": { "chemical_mass": 14334.0, "monoisotopic_mass": 14334.0 }, "refseq": { "ac": "NP_001160084", "name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" }, "gene_names": [ { "name": "SNRNP25", "type": "recommended", "evidence": [ { "id": "Q3ZBQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4" } ] }, { "name": "C25H16ORF33", "type": "synonym", "evidence": [ { "id": "NP_001160084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" } ] }, { "name": "SNRNP25", "type": "synonym", "evidence": [ { "id": "NP_001160084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" } ] } ], "protein_names": [ { "name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "type": "recommended", "evidence": [ { "id": "Q3ZBQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4/entry#names_and_taxonomy" } ] }, { "name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001160084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" } ] }, { "name": "U11/U12 snRNP 25 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001160084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" }, { "id": "Q3ZBQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4/entry#names_and_taxonomy" } ] }, { "name": "small nuclear ribonucleoprotein 25kDa (U11/U12)", "type": "synonym", "evidence": [ { "id": "NP_001160084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBQ4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP25", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4", "locus": { "chromosome": "25", "start_pos": 120817, "end_pos": 118409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019804", "url": "https://www.ensembl.org/id/ENSBTAG00000019804" } ] } } ], "crossref": [ { "id": "Q3ZBQ4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBQ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17058", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17058", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513526", "url": "https://www.ncbi.nlm.nih.gov/gene/513526", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513526", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513526", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KHVWANF", "url": "https://omabrowser.org/oma/group/KHVWANF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBQ4", "url": "https://www.orthodb.org/?gene=Q3ZBQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14942", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14942", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14942:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14942:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001160084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160084", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBQ4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLRQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 123, "header": "sp|Q3ZBQ4-1|SNR25_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 25 kDa protein OS=Bos taurus OX=9913 GN=SNRNP25 PE=2 SV=2 CANONICAL=Q3ZBQ4-1" }, "isoforms": [ { "isoform_ac": "Q3ZBQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4/entry#Q3ZBQ4-1", "sequence": { "sequence": "MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLRQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 123, "header": "sp|Q3ZBQ4-1|SNR25_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 25 kDa protein OS=Bos taurus OX=9913 GN=SNRNP25 PE=2 SV=2 CANONICAL=Q3ZBQ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513526", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513526", "resource": "KEGG Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZE11-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "Snrnp25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MENPETEVRPEVPEDDEDDEETLPHSEAVDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLKQEREGGVQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 160 }, "evidence": [ { "id": "Q3ZBQ4", "url": "https://omabrowser.org/oma/group/Q3ZBQ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IA47-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "Snrnp25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYMQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 123 }, "evidence": [ { "id": "Q3ZBQ4", "url": "https://omabrowser.org/oma/group/Q3ZBQ4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q84WS8-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "SNRNP25", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MESGDYDVETKREKLKSVLSQLLADPILADVPRNPTLSDVVTLVSLEKGSAMRLSVVKLDGSSLDVAVMNSATLKDLKLLIKKKVNEMEQANMGHRHISWKHVWSNFCLSCNNEKLLDDNAVLQDVGIRNNSQVTFMPYVMKKGRGRHSKRKKHRLFRSLHKTSS", "length": 165 }, "evidence": [ { "id": "Q3ZBQ4", "url": "https://omabrowser.org/oma/group/Q3ZBQ4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8VIK1-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "Snrnp25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLKQEREGGVQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 123 }, "evidence": [ { "id": "Q3ZBQ4", "url": "https://omabrowser.org/oma/group/Q3ZBQ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BV90-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "SNRNP25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQSATVLDLKKAIQRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 132 }, "evidence": [ { "id": "Q3ZBQ4", "url": "https://omabrowser.org/oma/group/Q3ZBQ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBQ4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBQ4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBQ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 123, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBQ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBQ4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBR1-1", "uniprot_ac": "Q3ZBR1", "uniprot_id": "SERP1_BOVIN", "mass": { "chemical_mass": 7374.0, "monoisotopic_mass": 7374.0 }, "refseq": { "ac": "NP_001107555", "name": "stress-associated endoplasmic reticulum protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555" }, "gene_names": [ { "name": "SERP1", "type": "recommended", "evidence": [ { "id": "Q3ZBR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ] }, { "name": "RAMP4", "type": "synonym", "evidence": [ { "id": "Q3ZBR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ] }, { "name": "SERP1", "type": "synonym", "evidence": [ { "id": "NP_001107555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555" } ] } ], "protein_names": [ { "name": "Stress-associated endoplasmic reticulum protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1/entry#names_and_taxonomy" } ] }, { "name": "Ribosome-attached membrane protein 4", "type": "synonym", "evidence": [ { "id": "Q3ZBR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1/entry#names_and_taxonomy" } ] }, { "name": "ribosome associated membrane protein 4", "type": "synonym", "evidence": [ { "id": "NP_001107555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555" } ] }, { "name": "ribosome-attached membrane protein 4", "type": "synonym", "evidence": [ { "id": "NP_001107555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555" } ] }, { "name": "stress-associated endoplasmic reticulum protein 1", "type": "synonym", "evidence": [ { "id": "NP_001107555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555" } ] } ], "function": [ { "annotation": "Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1#function" }, { "database": "UniProtKB", "id": "Q9R2C1", "url": "https://www.uniprot.org/uniprotkb/Q9R2C1#function" }, { "database": "UniProtKB", "id": "A0AAA9T9Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z9#function" }, { "database": "UniProtKB", "id": "ARBA00037157", "url": "https://www.uniprot.org/uniprotkb/ARBA00037157#function" } ] }, { "annotation": "Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z9#function" }, { "database": "UniProtKB", "id": "RU364120", "url": "https://www.uniprot.org/uniprotkb/RU364120#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1", "locus": { "chromosome": "1", "start_pos": 117600549, "end_pos": 117598268, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009104", "url": "https://www.ensembl.org/id/ENSBTAG00000009104" } ] } } ], "crossref": [ { "id": "Q3ZBR1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009104", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009104", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528100", "url": "https://www.ncbi.nlm.nih.gov/gene/528100", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010580", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010580", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528100", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528100", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KSNDAFH", "url": "https://omabrowser.org/oma/group/KSNDAFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBR1", "url": "https://www.orthodb.org/?gene=Q3ZBR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15601:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15601:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06624", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06624", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9609523", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9609523", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001107555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66, "header": "sp|Q3ZBR1-1|SERP1_BOVIN Isoform 1 of Stress-associated endoplasmic reticulum protein 1 OS=Bos taurus OX=9913 GN=SERP1 PE=3 SV=1 CANONICAL=Q3ZBR1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9Z9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1/entry#A0AAA9T9Z9-1", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSGKCFGVDRRVGCWDGFGDDVVTHEW", "length": 78, "header": "tr|A0AAA9T9Z9-1|A0AAA9T9Z9_BOVIN Computationally mapped isoform of Stress-associated endoplasmic reticulum protein OS=Bos taurus OX=9913 GN=SERP1 PE=3 SV=1 CANONICAL=Q3ZBR1-1" }, "locus": { "chromosome": "1", "start_pos": 117599158, "end_pos": 117598644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105381.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105381.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094845.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094845.1" } ] } }, { "isoform_ac": "Q3ZBR1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1/entry#Q3ZBR1-1", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66, "header": "sp|Q3ZBR1-1|SERP1_BOVIN Isoform 1 of Stress-associated endoplasmic reticulum protein 1 OS=Bos taurus OX=9913 GN=SERP1 PE=3 SV=1 CANONICAL=Q3ZBR1-1" }, "locus": { "chromosome": "1", "start_pos": 117600305, "end_pos": 117598644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012000.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012000.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012000.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012000.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528100", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528100", "resource": "KEGG Pathway" }, { "id": "R-BTA-9609523", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9609523", "resource": "Reactome", "description": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZIJ7-1", "protein_name": "Stress-associated endoplasmic reticulum protein", "gene_name": "SERP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66 }, "evidence": [ { "id": "Q3ZBR1", "url": "https://omabrowser.org/oma/group/Q3ZBR1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HG39-1", "protein_name": "Stress-associated endoplasmic reticulum protein", "gene_name": "Serp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66 }, "evidence": [ { "id": "Q3ZBR1", "url": "https://omabrowser.org/oma/group/Q3ZBR1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9R2C1-1", "protein_name": "Stress-associated endoplasmic reticulum protein 1", "gene_name": "Serp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66 }, "evidence": [ { "id": "Q3ZBR1", "url": "https://omabrowser.org/oma/group/Q3ZBR1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Z1W5-1", "protein_name": "Stress-associated endoplasmic reticulum protein 1", "gene_name": "Serp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM", "length": 66 }, "evidence": [ { "id": "Q3ZBR1", "url": "https://omabrowser.org/oma/group/Q3ZBR1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 66, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBR1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBS8-1", "uniprot_ac": "Q3ZBS8", "uniprot_id": "TIM8A_BOVIN", "mass": { "chemical_mass": 11014.0, "monoisotopic_mass": 11014.0 }, "refseq": { "ac": "NP_001029652", "name": "mitochondrial import inner membrane translocase subunit Tim8 A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029652" }, "gene_names": [ { "name": "TIMM8A", "type": "recommended", "evidence": [ { "id": "Q3ZBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ] }, { "name": "TIM8A", "type": "synonym", "evidence": [ { "id": "Q3ZBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ] }, { "name": "TIMM8A", "type": "synonym", "evidence": [ { "id": "NP_001029652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029652" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim8 A", "type": "recommended", "evidence": [ { "id": "Q3ZBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim8 A", "type": "synonym", "evidence": [ { "id": "NP_001029652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029652" } ] }, { "name": "translocase of inner mitochondrial membrane 8 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001029652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029652" } ] } ], "function": [ { "annotation": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM8A", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8", "locus": { "chromosome": "X", "start_pos": 50864655, "end_pos": 50861952, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022292", "url": "https://www.ensembl.org/id/ENSBTAG00000022292" } ] } } ], "crossref": [ { "id": "Q3ZBS8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022292", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022292", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515109", "url": "https://www.ncbi.nlm.nih.gov/gene/515109", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515109", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515109", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DLCYTGT", "url": "https://omabrowser.org/oma/group/DLCYTGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBS8", "url": "https://www.orthodb.org/?gene=Q3ZBS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF02953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029652", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSSSSSSAAGLGSVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD", "length": 97, "header": "sp|Q3ZBS8-1|TIM8A_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim8 A OS=Bos taurus OX=9913 GN=TIMM8A PE=3 SV=1 CANONICAL=Q3ZBS8-1" }, "isoforms": [ { "isoform_ac": "Q3ZBS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8/entry#Q3ZBS8-1", "sequence": { "sequence": "MDSSSSSSAAGLGSVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD", "length": 97, "header": "sp|Q3ZBS8-1|TIM8A_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim8 A OS=Bos taurus OX=9913 GN=TIMM8A PE=3 SV=1 CANONICAL=Q3ZBS8-1" }, "locus": { "chromosome": "X", "start_pos": 50863789, "end_pos": 50862009, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030129.4", "url": "https://www.ensembl.org/id/ENSBTAT00000030129.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000030114.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "site_lbl": "Ser57" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "site_lbl": "Ser87" }, { "start_pos": 94, "end_pos": 94, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "site_lbl": "Ser94" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "site_lbl": "Ser96" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515109", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515109", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S1L1-1", "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM8A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSSSSSSAAGLGSVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDNRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD", "length": 97 }, "evidence": [ { "id": "Q3ZBS8", "url": "https://omabrowser.org/oma/group/Q3ZBS8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O60220-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 A", "gene_name": "TIMM8A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSSSSSSAAGLGAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD", "length": 97 }, "evidence": [ { "id": "Q3ZBS8", "url": "https://omabrowser.org/oma/group/Q3ZBS8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVA1-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 A", "gene_name": "Timm8a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESSSSSSGSALAAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD", "length": 97 }, "evidence": [ { "id": "Q3ZBS8", "url": "https://omabrowser.org/oma/group/Q3ZBS8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial intermembrane space chaperone complex", "id": "GO:0042719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042719", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 97, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBS8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 57, 87, 94, 96 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBU3-1", "uniprot_ac": "Q3ZBU3", "uniprot_id": "TEDC2_BOVIN", "mass": { "chemical_mass": 48028.0, "monoisotopic_mass": 48028.0 }, "refseq": {}, "gene_names": [ { "name": "TEDC2", "type": "recommended", "evidence": [ { "id": "Q3ZBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3" } ] } ], "protein_names": [ { "name": "Tubulin epsilon and delta complex protein 2", "type": "recommended", "evidence": [ { "id": "Q3ZBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3#function" }, { "database": "UniProtKB", "id": "Q6GQV0", "url": "https://www.uniprot.org/uniprotkb/Q6GQV0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEDC2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3", "locus": { "chromosome": "25", "start_pos": 1970947, "end_pos": 1966625, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024884", "url": "https://www.ensembl.org/id/ENSBTAG00000024884" } ] } } ], "crossref": [ { "id": "Q3ZBU3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "616898", "url": "https://www.ncbi.nlm.nih.gov/gene/616898", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616898", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616898", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBU3", "url": "https://www.orthodb.org/?gene=Q3ZBU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14870:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14870:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15764", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192308", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBU3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPAECSRRLVAELRDALDSCAERQRQLEQSLRVSRRLLRVWEPAETPAPEPTPGSEINKEAPSSACPPSPQDLKELELLTQALEKAVRVRKGLSKAGEGVKARSLKSGSASTATKASAPPSTSRCTGSRAPETKPPRGVHHPWVPAKDLPGHRLLLVGDGAHMGQGAGANKPEAGLRDQQIVPQAASQVPEAFTLKDKGALLRLPEAFRKAASRNARLPMCASSLWAQLSSMQTRDSVDAAAATAKTQFLQKMQTAAGLPSSMLSAAEVGRLQKACSMLRLRMREELTADPKDWTQEYRSLLTLEGLQALAGQCLHRLQELQELRSAVVEQPQGPWPEGPPRAALPCGGGADPVWSPQLLLYSSTQELQTLAALRLRVAMLDQQVHLEKVLMAELLPLLSEQEPLGRPWLALCRAAHCLLCEGGQRFLTVLQDEPADRLSPP", "length": 443, "header": "sp|Q3ZBU3-1|TEDC2_BOVIN Isoform 1 of Tubulin epsilon and delta complex protein 2 OS=Bos taurus OX=9913 GN=TEDC2 PE=2 SV=2 CANONICAL=Q3ZBU3-1" }, "isoforms": [ { "isoform_ac": "Q3ZBU3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3/entry#Q3ZBU3-1", "sequence": { "sequence": "MLPAECSRRLVAELRDALDSCAERQRQLEQSLRVSRRLLRVWEPAETPAPEPTPGSEINKEAPSSACPPSPQDLKELELLTQALEKAVRVRKGLSKAGEGVKARSLKSGSASTATKASAPPSTSRCTGSRAPETKPPRGVHHPWVPAKDLPGHRLLLVGDGAHMGQGAGANKPEAGLRDQQIVPQAASQVPEAFTLKDKGALLRLPEAFRKAASRNARLPMCASSLWAQLSSMQTRDSVDAAAATAKTQFLQKMQTAAGLPSSMLSAAEVGRLQKACSMLRLRMREELTADPKDWTQEYRSLLTLEGLQALAGQCLHRLQELQELRSAVVEQPQGPWPEGPPRAALPCGGGADPVWSPQLLLYSSTQELQTLAALRLRVAMLDQQVHLEKVLMAELLPLLSEQEPLGRPWLALCRAAHCLLCEGGQRFLTVLQDEPADRLSPP", "length": 443, "header": "sp|Q3ZBU3-1|TEDC2_BOVIN Isoform 1 of Tubulin epsilon and delta complex protein 2 OS=Bos taurus OX=9913 GN=TEDC2 PE=2 SV=2 CANONICAL=Q3ZBU3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 53, "start_aa": "Thr", "end_pos": 53, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr53", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616898", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616898", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 443, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBU3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 53 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBV0-1", "uniprot_ac": "Q3ZBV0", "uniprot_id": "TSN13_BOVIN", "mass": { "chemical_mass": 22219.0, "monoisotopic_mass": 22219.0 }, "refseq": { "ac": "NP_001030439", "name": "tetraspanin-13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030439" }, "gene_names": [ { "name": "TSPAN13", "type": "recommended", "evidence": [ { "id": "Q3ZBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0" } ] }, { "name": "TSPAN13", "type": "synonym", "evidence": [ { "id": "NP_001030439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030439" } ] } ], "protein_names": [ { "name": "Tetraspanin-13", "type": "recommended", "evidence": [ { "id": "Q3ZBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0/entry#names_and_taxonomy" } ] }, { "name": "Tspan-13", "type": "synonym", "evidence": [ { "id": "Q3ZBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-13", "type": "synonym", "evidence": [ { "id": "NP_001030439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030439" } ] }, { "name": "tspan-13", "type": "synonym", "evidence": [ { "id": "NP_001030439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030439" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN13", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0", "locus": { "chromosome": "4", "start_pos": 25302689, "end_pos": 25245149, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012805", "url": "https://www.ensembl.org/id/ENSBTAG00000012805" } ] } } ], "crossref": [ { "id": "Q3ZBV0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012805", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012805", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526460", "url": "https://www.ncbi.nlm.nih.gov/gene/526460", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526460", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526460", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPPCAPI", "url": "https://omabrowser.org/oma/group/CPPCAPI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBV0", "url": "https://www.orthodb.org/?gene=Q3ZBV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF203", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF203", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBV0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204, "header": "sp|Q3ZBV0-1|TSN13_BOVIN Isoform 1 of Tetraspanin-13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=2 SV=1 CANONICAL=Q3ZBV0-1" }, "isoforms": [ { "isoform_ac": "Q3ZBV0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0/entry#Q3ZBV0-1", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204, "header": "sp|Q3ZBV0-1|TSN13_BOVIN Isoform 1 of Tetraspanin-13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=2 SV=1 CANONICAL=Q3ZBV0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 113, "start_aa": "Asn", "end_pos": 113, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn113", "evidence": [ { "id": "Q3ZBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 137, "start_aa": "Asn", "end_pos": 137, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn137", "evidence": [ { "id": "Q3ZBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0" } ], "site_lbl": "Ser143" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526460", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526460", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P7Y2-1", "protein_name": "Tetraspanin 13", "gene_name": "TSPAN13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSFRVVGVAIAVGIFLFFIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNKEQQSQLLEVGWNNTKSARTDLERNLNCCGFRFFDPNETCSSDCFRSHQCQPCAPIIEEYSGMVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 203 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SEI8-1", "protein_name": "Tetraspanin 13", "gene_name": "TSPAN13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIFQFSVSCACLALNQGQQSQLLEVGWNNTASARNDIQRNLNCCGFRRLNPNDTCLASCMKSRHSCSPCAPIIGKYAGEVLQFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95857-1", "protein_name": "Tetraspanin-13", "gene_name": "TSPAN13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQGQLLEVGWNNTASARNDIQRNLNCCGFRSVNPNDTCLASCVKSDHSCSPCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5FVL6-1", "protein_name": "Tetraspanin-13", "gene_name": "Tspan13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVCGGFSCSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNREQQGQLLEVGWNNTASARNDIQRNLNCCGFRNYNPNDTCPASCAKSNQKCSSCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D8C2-1", "protein_name": "Tetraspanin-13", "gene_name": "Tspan13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVCGGFSCSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNREQQGQLLEVGWNNTASARNDIQRNLNCCGFRSYNPNDTCPASCAKSTQKCSSCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 204 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VB99-1", "protein_name": "Tetraspanin 97E, isoform A", "gene_name": "Tsp97E", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCGGFTCSKNALIALNILYVMIGFLLIGVGVYARAASIVTNLPIVGGILACGVILICISMLGLAGAVKHHQVMLFFYMIILFMLFLIQFSIASSCLAVNSEQQQQFAEQGWMTVPTDLRKQVQDSLKCCGFNATAPSTTSVVPPSNEPSCELINQQCCAHSSEPDCRCEPCGPLLEDKIDYAFKLCGGLGIFFSFTEVLAVFLARRYRNQHDPCYLPARAVFPHDYLY", "length": 228 }, "evidence": [ { "id": "Q3ZBV0", "url": "https://omabrowser.org/oma/group/Q3ZBV0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBV0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBV0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBV0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 113, 137 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 143 ], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBW7-1", "uniprot_ac": "Q3ZBW7", "uniprot_id": "MFR1L_BOVIN", "mass": { "chemical_mass": 31712.0, "monoisotopic_mass": 31712.0 }, "refseq": { "ac": "NP_001029504", "name": "mitochondrial fission regulator 1-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" }, "gene_names": [ { "name": "MTFR1L", "type": "recommended", "evidence": [ { "id": "Q3ZBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ] }, { "name": "FAM54B", "type": "synonym", "evidence": [ { "id": "NP_001029504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" }, { "id": "Q3ZBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ] }, { "name": "MTFR1L", "type": "synonym", "evidence": [ { "id": "NP_001029504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" } ] } ], "protein_names": [ { "name": "Mitochondrial fission regulator 1-like", "type": "recommended", "evidence": [ { "id": "Q3ZBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 54, member B", "type": "synonym", "evidence": [ { "id": "NP_001029504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" } ] }, { "name": "mitochondrial fission regulator 1-like", "type": "synonym", "evidence": [ { "id": "NP_001029504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" } ] }, { "name": "protein FAM54B", "type": "synonym", "evidence": [ { "id": "NP_001029504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504" } ] } ], "function": [ { "annotation": "Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7#function" }, { "database": "UniProtKB", "id": "Q9H019", "url": "https://www.uniprot.org/uniprotkb/Q9H019#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTFR1L", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7", "locus": { "chromosome": "2", "start_pos": 127238786, "end_pos": 127253787, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021781", "url": "https://www.ensembl.org/id/ENSBTAG00000021781" } ] } } ], "crossref": [ { "id": "Q3ZBW7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021781", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021781", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508852", "url": "https://www.ncbi.nlm.nih.gov/gene/508852", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508852", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508852", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LRHKWKP", "url": "https://omabrowser.org/oma/group/LRHKWKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBW7", "url": "https://www.orthodb.org/?gene=Q3ZBW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029504", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBW7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEIEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLSRSSLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 289, "header": "sp|Q3ZBW7-1|MFR1L_BOVIN Isoform 1 of Mitochondrial fission regulator 1-like OS=Bos taurus OX=9913 GN=MTFR1L PE=2 SV=1 CANONICAL=Q3ZBW7-1" }, "isoforms": [ { "isoform_ac": "Q3ZBW7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7/entry#Q3ZBW7-1", "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEIEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLSRSSLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 289, "header": "sp|Q3ZBW7-1|MFR1L_BOVIN Isoform 1 of Mitochondrial fission regulator 1-like OS=Bos taurus OX=9913 GN=MTFR1L PE=2 SV=1 CANONICAL=Q3ZBW7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 100, "end_pos": 100, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser100" }, { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser107" }, { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser221" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser222" }, { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser235" }, { "start_pos": 258, "end_pos": 258, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser258" }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser270" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Thr27" }, { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "site_lbl": "Ser38" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508852", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508852", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1STT6-1", "protein_name": "Mitochondrial fission regulator", "gene_name": "MTFR1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "TSGMEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNLSDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLMVIQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEYKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLNRSLLKEEDPAILISEVLRRKFALKEEDMSRKGN", "length": 292 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I6A4-1", "protein_name": "Mitochondrial fission regulator", "gene_name": "Mtfr1l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASTSLTPDFLSPGSSNVSSPLPCFGSSLHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKPEHKATCSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 289 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XII9-1", "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "Mtfr1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSSGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTTCSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 289 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7T3E8-1", "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "mtfr1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "METEAEVIPIWQNKPHGSTRSVVRRIGSTLPLKPCPRACFQELPGLPSMRSLDGPLVPTLADIAWIADDEEETYARVRSDTRPLRHEWRPTPLLVMHRNSSVPNFRREGRRVEGLRKPGVTALNRTTALQDELSRLRAQIAKIVAADSDSNPITPDLLSPDDTSMGFSMAPFETAAYQPPPTASFVISDVTEEDEEEEEEEDREEEEEDVSELVPDPMPPVSMTASATFDLDRPTMDFREPEEDTVSLSKSTSFADVMDMLKDMNRLKMSKDRYNRGCTSLREEDSASLISEALRKKFVLKDDDISMRK", "length": 309 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CWE0-1", "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "Mtfr1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFFSSGSSNVSSPLPCFGSSLHSTTSFVISDITEETEVEVPELPTVPLLCSASPECCKPEHKTTCSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 289 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H019-1", "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "MTFR1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGMEATVTIPIWQNKPHGAARSVVRRIGTNLPLKPCARASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLNRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 292 }, "evidence": [ { "id": "Q3ZBW7", "url": "https://omabrowser.org/oma/group/Q3ZBW7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial fission", "id": "GO:0000266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000266", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBW7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 289, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBW7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBW7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 27, 38, 100, 107, 221, 222, 235, 258, 270 ], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBX1-1", "uniprot_ac": "Q3ZBX1", "uniprot_id": "PIGC_BOVIN", "mass": { "chemical_mass": 33628.0, "monoisotopic_mass": 33628.0 }, "refseq": { "ac": "NP_001029555", "name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555" }, "gene_names": [ { "name": "PIGC", "type": "recommended", "evidence": [ { "id": "Q3ZBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1" } ] }, { "name": "PIGC", "type": "synonym", "evidence": [ { "id": "NP_001029555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "type": "recommended", "evidence": [ { "id": "Q3ZBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1/entry#names_and_taxonomy" } ] }, { "name": "PIG-C", "type": "synonym", "evidence": [ { "id": "NP_001029555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555" }, { "id": "Q3ZBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class C protein", "type": "synonym", "evidence": [ { "id": "Q3ZBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "type": "synonym", "evidence": [ { "id": "NP_001029555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555" } ] }, { "name": "phosphatidylinositol-glycan biosynthesis class C protein", "type": "synonym", "evidence": [ { "id": "NP_001029555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555" } ] } ], "function": [ { "annotation": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1#function" }, { "database": "UniProtKB", "id": "Q92535", "url": "https://www.uniprot.org/uniprotkb/Q92535#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGC", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1", "locus": { "chromosome": "16", "start_pos": 39920196, "end_pos": 39930158, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024542", "url": "https://www.ensembl.org/id/ENSBTAG00000024542" } ] } } ], "crossref": [ { "id": "Q3ZBX1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024542", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024542", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510483", "url": "https://www.ncbi.nlm.nih.gov/gene/510483", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510483", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510483", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STSYHAF", "url": "https://omabrowser.org/oma/group/STSYHAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBX1", "url": "https://www.orthodb.org/?gene=Q3ZBX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12982", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12982", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12982:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12982:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-162710", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCAQPVANTKEVRWQKVLYERQPFPDNYVDRRFLEELRKNIYARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLIGYVLFDFIDGGEGRKKSGRTRWADLKSALVFITFTYGFSPVLKTLTESVSTDTIYAMAVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSALGGLLSISAVGAILFALLLISISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297, "header": "sp|Q3ZBX1-1|PIGC_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Bos taurus OX=9913 GN=PIGC PE=2 SV=1 CANONICAL=Q3ZBX1-1" }, "isoforms": [ { "isoform_ac": "Q3ZBX1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1/entry#Q3ZBX1-1", "sequence": { "sequence": "MCAQPVANTKEVRWQKVLYERQPFPDNYVDRRFLEELRKNIYARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLIGYVLFDFIDGGEGRKKSGRTRWADLKSALVFITFTYGFSPVLKTLTESVSTDTIYAMAVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSALGGLLSISAVGAILFALLLISISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297, "header": "sp|Q3ZBX1-1|PIGC_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Bos taurus OX=9913 GN=PIGC PE=2 SV=1 CANONICAL=Q3ZBX1-1" }, "locus": { "chromosome": "16", "start_pos": 39921659, "end_pos": 39920769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034135.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034135.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034036.1", "url": "https://www.ensembl.org/id/ENSBTAP00000034036.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510483", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510483", "resource": "KEGG Pathway" }, { "id": "R-BTA-162710", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "resource": "Reactome", "description": "Synthesis of glycosylphosphatidylinositol (GPI)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P2C6-1", "protein_name": "Phosphatidylinositol glycan anchor biosynthesis class C", "gene_name": "PIGC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVCAQVETSPRRCWQKVLYERQPFPDNYVDQRFLEELRKNIHARQYQYWNVVYESGVVVQQLCSVCVFVVTWWYMDAGLLSPQGLFGAALLTSLLGYVLFDAIDAGVGRRESGRTRWADLKSTLVFTAFTYGFSPVLKTLTESISTDTIYAMSAFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFVMVTFAMQIFALWPMLQKKLKARTPCCYVGVTALFALVALVGLASVSSVGAVLFASLLLSISCLCPYCLIRLQQLKDNIHGPWDEAEIKEDLSRFLM", "length": 297 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A2U8U156-1", "protein_name": "Phosphatidylinositol glycan anchor biosynthesis class C, isoform C", "gene_name": "PIG-C", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVKNGQSKRQPWVKNLYSNREYPDNYTDASFLKDLRTNLHCRIYTFGEAIAGITVLNNQISCITGFLILYQLMLSDSVSPTTILVPSCGITGIGYLCYRGRSLSWALLGEDSKTLVTVVLFGYLFSPMLHTLTQAISTDTIYTMTFFVLLGNLIFGHYGLDVAMVSKAVSLNAAIFGAICLASRLPTSYHAFVLLVEAAVFFVLYPIMTEANWHAGFMLPIFAICCMALYCISRPVLYLYASTTIFINFVCPFIFVWQQQYKFNIHGPWDEAIVEENTEENLDGNLXRQLRFSEQLPPRLGSGDVEEHFTDR", "length": 312 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "G3GZK2-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "Pigc", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCAQHLTDTTEVKWQKVLYERQPFPDNYVDQRFLEELRKNIYARKYQYWAVVFESSVVVQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLIGYVLFDLIDGGDGRKKSGRTRWADLKSTLVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKAYTPRSYVGVTLLFAFSAFGGLLSISGVGAILFALLLISISCLCPYYLIRLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O64761-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "PIGC", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MESNLAGDSIPGPKWRKVAYGGMQIGYDDNYTDESFLEEMVMNANVVRRDLLKVMKDSVSISQYLCIVALVVLVWVHTLESSLDENSLLLLDLSLLASGFLILLLTEEKMLSLSLLLRYLVNISFFTTGLYILAPIYQTLTRSISSDSIWAVTVSLLLLHLFLHDYSGSTIRAPGALKTPNLTSCISVNASIVASVFVASRLPSRLHVFAVMLFSLQVFLFAPLVTYCIKKFNFGLHLLFSFALMGLTLYSIYALHRLFFLVFLSLVLLVNVVCPYWLIRMQEYKFEINGPWDEAKLCFDITD", "length": 303 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P46961-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit", "gene_name": "GPI2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTRSPWKRLLWLKQEYPDNYTDPSFIELRARQKAESNQKSDRKLSEAARAQIRLDFISFYQTILNTSFIYITFTYIYYYGFDPIPPTIFLSFITLIISRTKVDPLLSSFMDVKSSLIITFAMLTLSPVLKSLSKTTASDSIWTLSFWLTLWYIFVISSTKSKDKPSNLSTNILVALVAVLSSRLSTTIDVFCFLLICIQLNIILPTYLSVTNKVVPIISNIIVYSFLNVALGWIYMLLIFFASVFYITVLPKWFIYWKINYHKRDNDLLSTWDARTPILD", "length": 280 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54M40-1", "protein_name": "Putative phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "pigC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNDHHLNHRIINNINASSSSSSSSSPVQTNININSANNTNNNNNNNNNNNNNNNNNNNNIDNKWKKNLYEKQPYSDNYTDETFLIGLVQNANFIKYDFWTVVLDSFTVSQQITSVILFAIIFFHSLKHTLTLPFLVAMAGGFLVLGYIAIIIIDPSANFLSIRSSFLHIILLFGTVYGLSPVLRTLTNSFSDDTIWALTFILLLAHLFFHDYGYTNNESQKFSAPVSLNAAIFASVLLGSRLPSNIHVFVLISYAIETFALFPIFRHHLKRHSMELHVGLTVILCVTCSLLLLGMSKLLALIYIGIIGTITFVCPLWLIFIQKYKNEINGPWDEASVISQSGGEF", "length": 345 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5PQQ4-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "Pigc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCAQHVADTSEVKWQKVLYERQPFPDNYVDQRFLEELRKNIYARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLVGYVLFDLIDGGDGRKKSGRTRWADLKSTLVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKAYTPRSYVGVTLLFAFSAFGGLLSISGVGAILFALLLFSISCLCPYYLIHLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q92535-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "PIGC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYAQPVTNTKEVKWQKVLYERQPFPDNYVDRRFLEELRKNIHARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPHWLLGTGLASSLIGYVLFDLIDGGEGRKKSGQTRWADLKSALVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSAVGGLLSISAVGAVLFALLLMSISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXR4-1", "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "Pigc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCAQRVTDTPEVKWQKVLYERQPFPDNYVDQRFLEELRKNIYARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLVGYVLFDLIDGGDGRKKSGRTRWADLKSTLVFITFTYGFSPVLKTLTESVSTDTIYAMAVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKAYTPRSYVGVTLLFAFSAFGGLLSISAVGAILFALLLFSISCLCPYYLIHLQLFKENIHGPWDEAEIKEDLSRFLS", "length": 297 }, "evidence": [ { "id": "Q3ZBX1", "url": "https://omabrowser.org/oma/group/Q3ZBX1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "id": "GO:0000506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000506", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBX7-1", "uniprot_ac": "Q3ZBX7", "uniprot_id": "ANKR1_BOVIN", "mass": { "chemical_mass": 36165.0, "monoisotopic_mass": 36165.0 }, "refseq": { "ac": "NP_001029550", "name": "ankyrin repeat domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029550" }, "gene_names": [ { "name": "ANKRD1", "type": "recommended", "evidence": [ { "id": "Q3ZBX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ] }, { "name": "ANKRD1", "type": "synonym", "evidence": [ { "id": "NP_001029550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029550" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain 1 (cardiac muscle)", "type": "synonym", "evidence": [ { "id": "NP_001029550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029550" } ] }, { "name": "ankyrin repeat domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029550" } ] } ], "function": [ { "annotation": "May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7", "locus": { "chromosome": "26", "start_pos": 12533108, "end_pos": 12542479, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011734", "url": "https://www.ensembl.org/id/ENSBTAG00000011734" } ] } } ], "crossref": [ { "id": "Q3ZBX7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510376", "url": "https://www.ncbi.nlm.nih.gov/gene/510376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYDCGEH", "url": "https://omabrowser.org/oma/group/QYDCGEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBX7", "url": "https://www.orthodb.org/?gene=Q3ZBX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24126", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24126", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24126:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24126:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBX7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMVLKVEELVTGKKKGNGDAGEFLPEDFRDGEYEAAVTLEKQEDLKTLPVHFVSLGEQQWKTEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYKKTKVPVVKEPEPEIVTEPVDVPMFLKAALENKLPVIEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLIEAGAQIEFRDMLESTAIHWASRGGSLDVLKLLLNKGAKISARDKLLSTPLHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLITYGADLNVKNCAGKTPMDLVLHWQNGTKAIFDSLKENSYKASRIAAF", "length": 319, "header": "sp|Q3ZBX7-1|ANKR1_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 1 OS=Bos taurus OX=9913 GN=ANKRD1 PE=2 SV=1 CANONICAL=Q3ZBX7-1" }, "isoforms": [ { "isoform_ac": "Q3ZBX7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7/entry#Q3ZBX7-1", "sequence": { "sequence": "MMVLKVEELVTGKKKGNGDAGEFLPEDFRDGEYEAAVTLEKQEDLKTLPVHFVSLGEQQWKTEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYKKTKVPVVKEPEPEIVTEPVDVPMFLKAALENKLPVIEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLIEAGAQIEFRDMLESTAIHWASRGGSLDVLKLLLNKGAKISARDKLLSTPLHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLITYGADLNVKNCAGKTPMDLVLHWQNGTKAIFDSLKENSYKASRIAAF", "length": 319, "header": "sp|Q3ZBX7-1|ANKR1_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 1 OS=Bos taurus OX=9913 GN=ANKRD1 PE=2 SV=1 CANONICAL=Q3ZBX7-1" }, "locus": { "chromosome": "26", "start_pos": 12542420, "end_pos": 12533843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015584.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015584.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015584.3", "url": "https://www.ensembl.org/id/ENSBTAP00000015584.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510376", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZEJ7-1", "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "ANKRD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPAGGCSGDVEDLPVTGKKTDDKESGSFLPEDFKTGEYEAAVKLEKQDDLRTASDHLSTQVDMAHGKEKKREAELKKKKLQERSKLESLEDLEKIIQLKKKKKCRKVKAPLLKEPEPEVITGPVDIAMFFRAALENKLPVIEKYLSDKGDPNVCDEYKRTALHRACSEGHLEVVKKLVEAGALLELKDMLESTALHWACRGGNLEIVKFLLDKGINRNARDKLRSTPLHVAVRTGQYDCAEHLIACEADLNAKDREGDTPMHDAVRLNRYKMVRLLILYGADLTIKNADGKTPMDLVLQWQNGTKELFNNLKNNSYKSAHLNKF", "length": 324 }, "evidence": [ { "id": "Q3ZBX7", "url": "https://omabrowser.org/oma/group/Q3ZBX7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q15327-1", "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "ANKRD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF", "length": 319 }, "evidence": [ { "id": "Q3ZBX7", "url": "https://omabrowser.org/oma/group/Q3ZBX7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q865U8-1", "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "ANKRD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMVLKVEELVTGKKNGGGDAGEFLPEDFRDGEYEAAVTLEKQEDLKTLPAHFVSLGEQQWKIEKEREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEVITEPVDVPRFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLIEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLITYGADLNVKNCAGKTPMDLVLNWQNGTKAIFDSLKENSYKASRIATF", "length": 319 }, "evidence": [ { "id": "Q3ZBX7", "url": "https://omabrowser.org/oma/group/Q3ZBX7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8R560-1", "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "Ankrd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMVFRVEELVTGKKNSNGSSGEFLPGEFRNGEYEAAVALEKQEDLKTLPANSVNLGEEQRKSEKVREAELKKKKLEQRSKLENLEDLEIIVQLKKRKKYKKTKVPVVKEPEPEIITEPVDVPRFLKAALENKLPVVEKFLSDKNSPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWACRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLMTFGADLNVKNCAGKTPMDLVLHWQNGTKAIFDSLKENAYKNSRIATF", "length": 319 }, "evidence": [ { "id": "Q3ZBX7", "url": "https://omabrowser.org/oma/group/Q3ZBX7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CR42-1", "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "Ankrd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMVLRVEELVTGKKNSNGAAGEFLPGEFRNGEYEAAVALEKQEDLKTLPANSVKQGEEQRKSEKLREAELKKKKLEQRSKLENLEDLEIIVQLKKRKKYKKTKVPVVKEPEPEIMTEPVDVPRFLKAALENKLPVVEKFLSDKNSPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWACRGGNADVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLMTFGADLKVKNCAGKTPMDLVLHWQSGTKAIFDSLKENAYKNSRIATF", "length": 319 }, "evidence": [ { "id": "Q3ZBX7", "url": "https://omabrowser.org/oma/group/Q3ZBX7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "titin binding", "id": "GO:0031432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031432", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "R-SMAD binding", "id": "GO:0070412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070412", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "I band", "id": "GO:0031674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031674", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "positive regulation of protein secretion", "id": "GO:0050714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050714", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cardiac muscle tissue morphogenesis", "id": "GO:0055008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055008", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "negative regulation of DNA biosynthetic process", "id": "GO:2000279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000279", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "response to muscle stretch", "id": "GO:0035994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035994", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "positive regulation of DNA damage response, signal transduction by p53 class mediator", "id": "GO:0043517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043517", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" }, { "name": "cellular response to interleukin-1", "id": "GO:0071347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 297, "end_pos": 299 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBY2-1", "uniprot_ac": "Q3ZBY2", "uniprot_id": "TAGL3_BOVIN", "mass": { "chemical_mass": 22485.0, "monoisotopic_mass": 22485.0 }, "refseq": { "ac": "NP_001029671", "name": "transgelin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029671" }, "gene_names": [ { "name": "TAGLN3", "type": "recommended", "evidence": [ { "id": "Q3ZBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ] }, { "name": "TAGLN3", "type": "synonym", "evidence": [ { "id": "NP_001029671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029671" } ] } ], "protein_names": [ { "name": "Transgelin-3", "type": "recommended", "evidence": [ { "id": "Q3ZBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2/entry#names_and_taxonomy" } ] }, { "name": "transgelin-3", "type": "synonym", "evidence": [ { "id": "NP_001029671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029671" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAGLN3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2", "locus": { "chromosome": "1", "start_pos": 56773632, "end_pos": 56759807, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004599", "url": "https://www.ensembl.org/id/ENSBTAG00000004599" } ] } } ], "crossref": [ { "id": "Q3ZBY2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004599", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004599", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21281", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21281", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515562", "url": "https://www.ncbi.nlm.nih.gov/gene/515562", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515562", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515562", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI04", "url": "https://www.orthodb.org/?gene=A0A452DI04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBY2", "url": "https://www.orthodb.org/?gene=Q3ZBY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029671", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI04", "url": "https://www.uniprot.org/uniprotkb/A0A452DI04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI04-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBY2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAEIYGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM", "length": 199, "header": "sp|Q3ZBY2-1|TAGL3_BOVIN Isoform 1 of Transgelin-3 OS=Bos taurus OX=9913 GN=TAGLN3 PE=2 SV=1 CANONICAL=Q3ZBY2-1" }, "isoforms": [ { "isoform_ac": "A0A452DI04-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2/entry#A0A452DI04-1", "sequence": { "sequence": "MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAEIYGVRTTDIFQTVDLWEGKQLSHAFDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM", "length": 186, "header": "tr|A0A452DI04-1|A0A452DI04_BOVIN Computationally mapped isoform of Transgelin OS=Bos taurus OX=9913 GN=TAGLN3 PE=3 SV=1 CANONICAL=Q3ZBY2-1" }, "locus": { "chromosome": "1", "start_pos": 56773306, "end_pos": 56759915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006033.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006033.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006033.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006033.4" } ] } }, { "isoform_ac": "Q3ZBY2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2/entry#Q3ZBY2-1", "sequence": { "sequence": "MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAEIYGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM", "length": 199, "header": "sp|Q3ZBY2-1|TAGL3_BOVIN Isoform 1 of Transgelin-3 OS=Bos taurus OX=9913 GN=TAGLN3 PE=2 SV=1 CANONICAL=Q3ZBY2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "site_lbl": "Ser163" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515562", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515562", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBY2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 199, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBY2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBY2" }, { "id": "PRU00044", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000255", "start_pos": 24, "end_pos": 136, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 163 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC08-1", "uniprot_ac": "Q3ZC08", "uniprot_id": "ANXA9_BOVIN", "mass": { "chemical_mass": 38293.0, "monoisotopic_mass": 38293.0 }, "refseq": { "ac": "NP_001030450", "name": "annexin A9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" }, "gene_names": [ { "name": "ANXA9", "type": "recommended", "evidence": [ { "id": "Q3ZC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ] }, { "name": "ANXA9", "type": "synonym", "evidence": [ { "id": "NP_001030450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" } ] } ], "protein_names": [ { "name": "Annexin A9", "type": "recommended", "evidence": [ { "id": "Q3ZC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08/entry#names_and_taxonomy" } ] }, { "name": "Annexin-9", "type": "synonym", "evidence": [ { "id": "Q3ZC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08/entry#names_and_taxonomy" } ] }, { "name": "annexin A9", "type": "synonym", "evidence": [ { "id": "NP_001030450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" } ] }, { "name": "annexin-9", "type": "synonym", "evidence": [ { "id": "NP_001030450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" } ] } ], "function": [ { "annotation": "ANXA9 gene frequency and SNP genotypes in Holstein-Friesian cows and its relationship with protein and fat content in milk", "evidence": [ { "database": "RefSeq", "id": "NP_001030450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" }, { "database": "PubMed", "id": "25474885", "url": "https://glygen.org/publication/PubMed/25474885" } ] }, { "annotation": "Gene mapped by single nucleotide polymorphism.", "evidence": [ { "database": "RefSeq", "id": "NP_001030450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" }, { "database": "PubMed", "id": "16717448", "url": "https://glygen.org/publication/PubMed/16717448" } ] }, { "annotation": "Plays a role in epidermal differentiation (By similarity). Can bind acetylcholine (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08#function" }, { "database": "UniProtKB", "id": "O76027", "url": "https://www.uniprot.org/uniprotkb/O76027#function" }, { "database": "UniProtKB", "id": "Q9JHQ0", "url": "https://www.uniprot.org/uniprotkb/Q9JHQ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANXA9", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08", "locus": { "chromosome": "3", "start_pos": 19776925, "end_pos": 19786445, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015304", "url": "https://www.ensembl.org/id/ENSBTAG00000015304" } ] } } ], "crossref": [ { "id": "Q3ZC08", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC08", "database": "AlphaFoldDB", "categories": [] }, { "id": "528055", "url": "https://www.ncbi.nlm.nih.gov/gene/528055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528055", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528055", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZC08", "url": "https://www.orthodb.org/?gene=Q3ZC08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF122", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF122", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC08-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVTHGKMGLSLTQEILSHLGLANKTAAWGTLGTLRTFLSFSADKDVQRLLKAIAGQGVDRIAILDVLTNRSREQRQLISRAFHERTQQDLLKSLQAALSGNLERIVVALLQPAAHLDARELRTALKGSGSAEDVALEILATRTPPQLQECLAVYKHNFQVDAAEDIKSETRGILRDLLLALAKGGREAYTGIIDYNLAAQDVQALKQAEGPSTERTWVLVFTQRNPEHLVRVLNQYQWYTGHGLEKTVRARFHGAACVALLNLASVIRNTPLYFADKLHQALQETEPNYQALMRILISRSETDLLSIRAEFRKKFGKSLYSSLQDAVKGDCRSALLALCRAEDL", "length": 345, "header": "sp|Q3ZC08-1|ANXA9_BOVIN Isoform 1 of Annexin A9 OS=Bos taurus OX=9913 GN=ANXA9 PE=2 SV=1 CANONICAL=Q3ZC08-1" }, "isoforms": [ { "isoform_ac": "Q3ZC08-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08/entry#Q3ZC08-1", "sequence": { "sequence": "MSVTHGKMGLSLTQEILSHLGLANKTAAWGTLGTLRTFLSFSADKDVQRLLKAIAGQGVDRIAILDVLTNRSREQRQLISRAFHERTQQDLLKSLQAALSGNLERIVVALLQPAAHLDARELRTALKGSGSAEDVALEILATRTPPQLQECLAVYKHNFQVDAAEDIKSETRGILRDLLLALAKGGREAYTGIIDYNLAAQDVQALKQAEGPSTERTWVLVFTQRNPEHLVRVLNQYQWYTGHGLEKTVRARFHGAACVALLNLASVIRNTPLYFADKLHQALQETEPNYQALMRILISRSETDLLSIRAEFRKKFGKSLYSSLQDAVKGDCRSALLALCRAEDL", "length": 345, "header": "sp|Q3ZC08-1|ANXA9_BOVIN Isoform 1 of Annexin A9 OS=Bos taurus OX=9913 GN=ANXA9 PE=2 SV=1 CANONICAL=Q3ZC08-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Isolation, mapping and identification of SNPs for four genes (ACP6, CGN, ANXA9, SLC27A3) from a bovine QTL region on BTA3.", "journal": "Cytogenetic and genome research", "date": "2006", "authors": "Calvo J H, Mart\u00ednez-Royo A, Silveri L, Floriot S, Eggen A, Marcos-Carcavilla A, Serrano M", "evidence": [ { "database": "RefSeq", "id": "NP_001030450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" } ], "reference": [ { "type": "PubMed", "id": "16717448", "url": "https://glygen.org/publication/PubMed/16717448" } ] }, { "title": "FABP3, FABP4 and ANXA9 SNP genotypes in relation to breeding values for milk production traits in Polish Holstein-Friesian cows.", "journal": "Genetika", "date": "2013-08", "authors": "Kulig H, Kowalewska-Luczak I, Zukowski K, Kruszy\u0144ski W", "evidence": [ { "database": "RefSeq", "id": "NP_001030450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030450" } ], "reference": [ { "type": "PubMed", "id": "25474885", "url": "https://glygen.org/publication/PubMed/25474885" } ] } ], "pathway": [ { "id": "bta:528055", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528055", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "lateral plasma membrane", "id": "GO:0016328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016328", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "vesicle membrane", "id": "GO:0012506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012506", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC08", "url": "https://www.uniprot.org/uniprotkb/Q3ZC08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC08" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZC21-1", "uniprot_ac": "Q3ZC21", "uniprot_id": "MI4GD_BOVIN", "mass": { "chemical_mass": 25395.0, "monoisotopic_mass": 25395.0 }, "refseq": { "ac": "NP_001029904", "name": "MIF4G domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029904" }, "gene_names": [ { "name": "MIF4GD", "type": "recommended", "evidence": [ { "id": "Q3ZC21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ] }, { "name": "MIF4GD", "type": "synonym", "evidence": [ { "id": "NP_001029904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029904" } ] } ], "protein_names": [ { "name": "MIF4G domain-containing protein", "type": "recommended", "evidence": [ { "id": "Q3ZC21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21/entry#names_and_taxonomy" } ] }, { "name": "MIF4G domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001029904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029904" } ] } ], "function": [ { "annotation": "Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIF4GD", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21", "locus": { "chromosome": "19", "start_pos": 56223502, "end_pos": 56220013, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030168", "url": "https://www.ensembl.org/id/ENSBTAG00000030168" } ] } } ], "crossref": [ { "id": "Q3ZC21", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030168", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030168", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613305", "url": "https://www.ncbi.nlm.nih.gov/gene/613305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCCSCTG", "url": "https://omabrowser.org/oma/group/PCCSCTG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC21", "url": "https://www.orthodb.org/?gene=Q3ZC21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23254:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23254:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02854", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02854", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029904", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC21-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEPSKEEYKIQCFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDSVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQTREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPAGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD", "length": 222, "header": "sp|Q3ZC21-1|MI4GD_BOVIN Isoform 1 of MIF4G domain-containing protein OS=Bos taurus OX=9913 GN=MIF4GD PE=2 SV=1 CANONICAL=Q3ZC21-1" }, "isoforms": [ { "isoform_ac": "Q3ZC21-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21/entry#Q3ZC21-1", "sequence": { "sequence": "MGEPSKEEYKIQCFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDSVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQTREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPAGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD", "length": 222, "header": "sp|Q3ZC21-1|MI4GD_BOVIN Isoform 1 of MIF4G domain-containing protein OS=Bos taurus OX=9913 GN=MIF4GD PE=2 SV=1 CANONICAL=Q3ZC21-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZK28-1", "protein_name": "MIF4G domain-containing protein", "gene_name": "MIF4GD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVMGEPGREEYRIQSFDAESQQLLKTALKDPGAVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNRQRMDELFVLIRDGFLLPTGLSSLAQLLLLETIEFRAAGWKTTPAAHKYYYSELSD", "length": 224 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A9UHW6-1", "protein_name": "MIF4G domain-containing protein", "gene_name": "MIF4GD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEPSREEYKIQSFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPTGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD", "length": 222 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "G3GTE7-1", "protein_name": "MIF4G domain-containing protein", "gene_name": "Mif4gd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEASRDEYKIQSFDAETQQLLKTALKDPGTVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLDRLQREYQAREQLRARSLQSWVCYVTFICNIFDYLRVNNMPMLALVNPVYDCLFQLAQPESLSREEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPLGLSSLGRLLLLEMIEFRAAGWKTTPAAHKYYYSEVSD", "length": 222 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3UBZ5-1", "protein_name": "MIF4G domain-containing protein", "gene_name": "Mif4gd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEASRDDYKIQSFDAETQQLLKTALKDPGAVDLERVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQKEYDAREQLRACSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFQLAQPESLSREEEVDCLVLQLHRVGEQLEKMNGQRMDELFILIRDGFLLPTDLSSLARLLLLEMIEFRAAGWKTTPAAHKYYYSEVSD", "length": 222 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5EAQ1-1", "protein_name": "MIF4G domain-containing protein B", "gene_name": "mif4gdb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENSSKEDYKIQSFDLETQKLLKTALKDPGSVDLEKVSSVIVDQSLKDQVFSREAGRICYTIVQAEAKQTNGSVFRRNLLNRLQQEFKAREETRKRSTQEWVCLVSFICNIFDYLKVNNMPMVALVHPVYDCLFRLAQSDALKNEEEVDCLVLQLHRIGDQLEKMNVQLMDELFNLLRDGFLLQEDLSSMGRLLLLEILEFRAGGWKLSDTAQKYYYSEVTD", "length": 222 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "R4GJG3-1", "protein_name": "MIF4G domain containing", "gene_name": "MIF4GD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGETSKEEYKIQSFDIETQKLLKTALKDPSNVDLDKVANIIVDQSLKDCVFSKEAGRICYTIIQAESKQGGQSIFRRSLLNRLQQEYKDREDLRNRSLQAWICYVTFICNIFDYLKVNNMPMLALVNPVYDCLFRLAQHDSLQKEEEVDCLVLQLHRVGEQLEKMNSQRMDELFSLLRDGFLLQEGLSSLSQLLLLEIIEFRAADWKMTDAAQKYYYSEVTD", "length": 222 }, "evidence": [ { "id": "Q3ZC21", "url": "https://omabrowser.org/oma/group/Q3ZC21/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" }, { "name": "translation activator activity", "id": "GO:0008494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008494", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" }, { "name": "histone mRNA stem-loop binding complex", "id": "GO:0062073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062073", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of translational initiation", "id": "GO:0006446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006446", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC21", "url": "https://www.uniprot.org/uniprotkb/Q3ZC21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 222, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC21" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC27-1", "uniprot_ac": "Q3ZC27", "uniprot_id": "RAB19_BOVIN", "mass": { "chemical_mass": 24485.0, "monoisotopic_mass": 24485.0 }, "refseq": { "ac": "NP_001030212", "name": "ras-related protein Rab-19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030212" }, "gene_names": [ { "name": "RAB19", "type": "recommended", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "name": "RAB19", "type": "synonym", "evidence": [ { "id": "NP_001030212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030212" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-19", "type": "recommended", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27/entry#names_and_taxonomy" } ] }, { "name": "ras-related protein Rab-19", "type": "synonym", "evidence": [ { "id": "NP_001030212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030212" } ] } ], "function": [ { "annotation": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27#function" }, { "database": "UniProtKB", "id": "Q9H0U4", "url": "https://www.uniprot.org/uniprotkb/Q9H0U4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB19", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27", "locus": { "chromosome": "4", "start_pos": 103806850, "end_pos": 103792919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012261", "url": "https://www.ensembl.org/id/ENSBTAG00000012261" } ] } } ], "crossref": [ { "id": "Q3ZC27", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC27", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012261", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012261", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01864", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01864", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506911", "url": "https://www.ncbi.nlm.nih.gov/gene/506911", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506911", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506911", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DMWEKRH", "url": "https://omabrowser.org/oma/group/DMWEKRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC27", "url": "https://www.orthodb.org/?gene=Q3ZC27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47979", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47979", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030212", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC27-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQFSSSARTVDENFDYLFKIILIGDSNVGKTCVVQHFKSGVYMEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACILAEKYGLLAVLETSAKESKNIDEVFVLMARELMARHSLPLYGEGAPGSLPLESTPVLMAPAPREKNQCTC", "length": 217, "header": "sp|Q3ZC27-1|RAB19_BOVIN Isoform 1 of Ras-related protein Rab-19 OS=Bos taurus OX=9913 GN=RAB19 PE=2 SV=1 CANONICAL=Q3ZC27-1" }, "isoforms": [ { "isoform_ac": "Q3ZC27-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27/entry#Q3ZC27-1", "sequence": { "sequence": "MQFSSSARTVDENFDYLFKIILIGDSNVGKTCVVQHFKSGVYMEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACILAEKYGLLAVLETSAKESKNIDEVFVLMARELMARHSLPLYGEGAPGSLPLESTPVLMAPAPREKNQCTC", "length": 217, "header": "sp|Q3ZC27-1|RAB19_BOVIN Isoform 1 of Ras-related protein Rab-19 OS=Bos taurus OX=9913 GN=RAB19 PE=2 SV=1 CANONICAL=Q3ZC27-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:506911", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506911", "resource": "KEGG Pathway" }, { "id": "R-BTA-8873719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0JFN3-1", "protein_name": "Ras-related protein Rab-19", "gene_name": "RAB19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQFSSSARAADENFDYLFKVILVGDSNVGKTCVVQHFKSGVYTEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESKNIDEVFVLMARELIARNSLPLYAEGALSSLPLDSSPVLTVSPREKTQCTC", "length": 216 }, "evidence": [ { "id": "Q3ZC27", "url": "https://omabrowser.org/oma/group/Q3ZC27/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A4D1S5-1", "protein_name": "Ras-related protein Rab-19", "gene_name": "RAB19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHFSSSARAADENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLDIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGAANVVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESKNIEEVFVLMAKELIARNSLHLYGESALNGLPLDSSPVLMAQGPSEKTHCTC", "length": 217 }, "evidence": [ { "id": "Q3ZC27", "url": "https://omabrowser.org/oma/group/Q3ZC27/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1P278-1", "protein_name": "Ras-related protein Rab-19", "gene_name": "RAB19", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPFSSSSADDAFDYLFKIILIGDSNVGKTCVVHRFKTGQFYEKQQNTIGVDFTVRSMDIDGKKVKIQVWDTAGQERFRTITQSYYRSAHGAILAYDLTRRSTFESIPHWVHEVEKYGAANLVMMLIGNKSDSVDKRQVLFEDACTLAEKYGLLAVLETSAKEAQNIEEVFVLMAKELIARNTLQLHGESPPNSVYLDSRPVITSPSAEKTQCLC", "length": 214 }, "evidence": [ { "id": "Q3ZC27", "url": "https://omabrowser.org/oma/group/Q3ZC27/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P35294-1", "protein_name": "Ras-related protein Rab-19", "gene_name": "Rab19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQFSSSSRTSDENVDYLFKVILIGDSNVGKTCVVQHFKSGVYSESQQNTIGVDFTVRSLEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKSDLWEKRHVLFEDACTLAEKHGLLAVLETSAKESRNIDEVFVLMAKELIARNSLHLYGESAQQGLSQDSSPVLVAQVPNESTRCTC", "length": 217 }, "evidence": [ { "id": "Q3ZC27", "url": "https://omabrowser.org/oma/group/Q3ZC27/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5M7U5-1", "protein_name": "Ras-related protein Rab-19", "gene_name": "Rab19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQFSSAARTVDENVDYLFKVILIGDSNVGKTCVVQHFKSGVYSESQQNTIGVDFTVRSLEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKSDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESRNIDEVFVLMAKELIARNSLHLYGESAQQGLPQDSSPVLVAHVPSERTHCTC", "length": 217 }, "evidence": [ { "id": "Q3ZC27", "url": "https://omabrowser.org/oma/group/Q3ZC27/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC27", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-BTA-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870466" } ] }, { "id": "R-BTA-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MWA3", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC27-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC27-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC27" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Switch 1", "eco_id": "ECO_0000250", "start_pos": 39, "end_pos": 54, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Switch 2", "eco_id": "ECO_0000250", "start_pos": 74, "end_pos": 89, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27#function" }, { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "binding_site_uniprot": 31, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 31, "end_pos": 31, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27#function" }, { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "binding_site_uniprot": 49, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 49, "end_pos": 49, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27#function" }, { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ], "binding_site_uniprot": 72, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 72, "end_pos": 72, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC49-1", "uniprot_ac": "Q3ZC49", "uniprot_id": "LRC39_BOVIN", "mass": { "chemical_mass": 38787.0, "monoisotopic_mass": 38787.0 }, "refseq": { "ac": "NP_001069893", "name": "leucine-rich repeat-containing protein 39", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893" }, "gene_names": [ { "name": "LRRC39", "type": "recommended", "evidence": [ { "id": "Q3ZC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49" } ] }, { "name": "LRRC39", "type": "synonym", "evidence": [ { "id": "NP_001069893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 39", "type": "recommended", "evidence": [ { "id": "Q3ZC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49/entry#names_and_taxonomy" } ] }, { "name": "Myomasp", "type": "synonym", "evidence": [ { "id": "Q3ZC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49/entry#names_and_taxonomy" } ] }, { "name": "Myosin-interacting M-band-associated stress-responsive protein", "type": "synonym", "evidence": [ { "id": "Q3ZC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 39", "type": "synonym", "evidence": [ { "id": "NP_001069893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893" } ] }, { "name": "myomasp", "type": "synonym", "evidence": [ { "id": "NP_001069893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893" } ] }, { "name": "myosin-interacting M-band-associated stress-responsive protein", "type": "synonym", "evidence": [ { "id": "NP_001069893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893" } ] } ], "function": [ { "annotation": "Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC49", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49#function" }, { "database": "UniProtKB", "id": "D3ZXS4", "url": "https://www.uniprot.org/uniprotkb/D3ZXS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC49", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC39", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49", "locus": { "chromosome": "3", "start_pos": 43122021, "end_pos": 43100659, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015786", "url": "https://www.ensembl.org/id/ENSBTAG00000015786" } ] } } ], "crossref": [ { "id": "Q3ZC49", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015786", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015786", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616488", "url": "https://www.ncbi.nlm.nih.gov/gene/616488", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616488", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616488", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DMPALEW", "url": "https://omabrowser.org/oma/group/DMPALEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC49", "url": "https://www.orthodb.org/?gene=Q3ZC49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZC49", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC49-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSENVVSTGAVNAVKEVWEKRIKKLNEDLKREKEFQQKLVRIWEERVCLTKLREKVTKEDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRIGLLKIPEFIGRFQNLIVLDLSRNTITEIPRGIGLLTRLQELILSYNRIKTVPMELSYCASLEKLELAVNRDISDLPQELSNLLKLTHLDLSMNLFTTIPPAVLNMPALEWLDMGSNRLEQLPDTIERMQNLHTLWLQRNEITCLPETISSMKNLSTLVLSNNKLQDIPVCMEKMTNLRFVNFRDNPLKLEVTLPPSENIEEEEERELFGLQFMHTYIQESRRAGNQVNCSTTSPNSIDADG", "length": 334, "header": "sp|Q3ZC49-1|LRC39_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 39 OS=Bos taurus OX=9913 GN=LRRC39 PE=2 SV=1 CANONICAL=Q3ZC49-1" }, "isoforms": [ { "isoform_ac": "Q3ZC49-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49/entry#Q3ZC49-1", "sequence": { "sequence": "MSENVVSTGAVNAVKEVWEKRIKKLNEDLKREKEFQQKLVRIWEERVCLTKLREKVTKEDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRIGLLKIPEFIGRFQNLIVLDLSRNTITEIPRGIGLLTRLQELILSYNRIKTVPMELSYCASLEKLELAVNRDISDLPQELSNLLKLTHLDLSMNLFTTIPPAVLNMPALEWLDMGSNRLEQLPDTIERMQNLHTLWLQRNEITCLPETISSMKNLSTLVLSNNKLQDIPVCMEKMTNLRFVNFRDNPLKLEVTLPPSENIEEEEERELFGLQFMHTYIQESRRAGNQVNCSTTSPNSIDADG", "length": 334, "header": "sp|Q3ZC49-1|LRC39_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 39 OS=Bos taurus OX=9913 GN=LRRC39 PE=2 SV=1 CANONICAL=Q3ZC49-1" }, "locus": { "chromosome": "3", "start_pos": 43121819, "end_pos": 43104149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053822.5", "url": "https://www.ensembl.org/id/ENSBTAT00000053822.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048641.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048641.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616488", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616488", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZPF1-1", "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "LRRC39", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNHGKSLKTKYLSCSPVIEPEHVRIMTETAVCIGSFTAVKTLWEVRIQKINEELRKEKEFRERSAGRLLLVWEERATLAKLKEKVINEDGRAVLKIEEEEWKTLPSCLLKLVHLQEWQLHRTSLQKIPQFVGRFHNLVVLDLSRNSIESIPKEIGQLTGLQELLLSYNRIKFVPKEISNCISLERLELAVNRNIRDLPPQLSDLKKLSHIDLCMNQFTTIPSALLSMPNLEWLDMGGNQLQKLPDAIDRMENLHTLWLQRNEINSLPETIVNMKNLSTLVLSNNKLKDIPSCMMHMTNLRFVNFRDNPLELEITLPPCEKTEEEEQQEMFGIEFMHMYIQESLKKTGNVESCTSDTSPIITANAEGT", "length": 367 }, "evidence": [ { "id": "Q3ZC49", "url": "https://omabrowser.org/oma/group/Q3ZC49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZXS4-1", "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "Lrrc39", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTESVVCTGAVSTVKEVWEERIKKHHEDVKREKEFQQKLVRIWEDRVSLTKLKEKVTREDGRIILRIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDISDLPTELSKLLKLTHLDLSMNQFTTIPLAVLDMPALEWLDMGSNSLQQLPDTLDRMQSLHTLWLQRNEITCLPETIRNMKNLGTLVLSNNKLQDIPGCMEEMTSLRFVNFRDNPLRLEVTLPPSDDVDGEEEQELFGLQFMHAYIQESRRTEDQVNCLTHTPSSTRSDG", "length": 334 }, "evidence": [ { "id": "Q3ZC49", "url": "https://omabrowser.org/oma/group/Q3ZC49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1R6I3-1", "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "lrrc39", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTGVTVCCGTVNSIKALWETRIKKTKDDLKKEKEQKDRRAVGRLTGAWEDRIILAKLKEKIVTEEGRVILRIEKEEWKTLPPALVQLSQIQEWQLHRIGLQRIPRFISSFQSLIVLDLSRNSVTEIPKEIGKLTRLRELLLSYNRVSYVPEELGCCENLEKLELAMNRDLDELPTQLSNLKKLSHLDLSMNQFTTIPDCVVNLPSLEWLDMGSNILETLPDNIHRMEKLHTLWLPRNELEYLPDNISRMKSLDTLVLSKNKLRDIPPLMEGMSNLRFVNFRDNPLTYDVTLPDLNEDVEEEENDREMFGREFMNFYIQEARKRGSQNFTSVLNVMLEGVSETA", "length": 343 }, "evidence": [ { "id": "Q3ZC49", "url": "https://omabrowser.org/oma/group/Q3ZC49/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BGI7-1", "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "Lrrc39", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTESAVCTGAVSAVKEVWEERIKKHHEDVKREKEFQHKLVRIWEDRVSLTKLKEKVTREDGRVILRIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSDNTDGEEEQELFGLQFMHAYIQESRRTEDQVNCLTQMPSSIHSDGESN", "length": 337 }, "evidence": [ { "id": "Q3ZC49", "url": "https://omabrowser.org/oma/group/Q3ZC49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DD0-1", "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "LRRC39", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTENVVCTGAVNAVKEVWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRRRADHQVNGSTTLPISINTDG", "length": 335 }, "evidence": [ { "id": "Q3ZC49", "url": "https://omabrowser.org/oma/group/Q3ZC49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC49", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC49", "url": "https://www.uniprot.org/uniprotkb/Q3ZC49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 334, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 }, { "start_pos": 321, "end_pos": 323 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC61-1", "uniprot_ac": "Q3ZC61", "uniprot_id": "MOFA1_BOVIN", "mass": { "chemical_mass": 14680.0, "monoisotopic_mass": 14680.0 }, "refseq": {}, "gene_names": [ { "name": "MRFAP1", "type": "recommended", "evidence": [ { "id": "Q3ZC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61" } ] } ], "protein_names": [ { "name": "MORF4 family-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC61", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRFAP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61", "locus": {} } ], "crossref": [ { "id": "Q3ZC61", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC61", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046936", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046936", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522338", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522338", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RVTKRCE", "url": "https://omabrowser.org/oma/group/RVTKRCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC61", "url": "https://www.orthodb.org/?gene=Q3ZC61", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31324:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31324:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q3ZC61", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC61-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPLDIVELAEPEEVEVLEPEEDFEQFLLPVINEMREDIAALSREHGRAYLRNRSKLWEMDNMLIQIKTQVEASEESALNHLQNPDDGAEGRGTKRCEKAEEKAKEIAKMAEMLVELVRRIEKSESS", "length": 127, "header": "sp|Q3ZC61-1|MOFA1_BOVIN Isoform 1 of MORF4 family-associated protein 1 OS=Bos taurus OX=9913 GN=MRFAP1 PE=2 SV=1 CANONICAL=Q3ZC61-1" }, "isoforms": [ { "isoform_ac": "Q3ZC61-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61/entry#Q3ZC61-1", "sequence": { "sequence": "MRPLDIVELAEPEEVEVLEPEEDFEQFLLPVINEMREDIAALSREHGRAYLRNRSKLWEMDNMLIQIKTQVEASEESALNHLQNPDDGAEGRGTKRCEKAEEKAKEIAKMAEMLVELVRRIEKSESS", "length": 127, "header": "sp|Q3ZC61-1|MOFA1_BOVIN Isoform 1 of MORF4 family-associated protein 1 OS=Bos taurus OX=9913 GN=MRFAP1 PE=2 SV=1 CANONICAL=Q3ZC61-1" }, "locus": { "chromosome": "6", "start_pos": 113177814, "end_pos": 113177434, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065893.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065893.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056519.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056519.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522338", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522338", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GWD2-1", "protein_name": "MORF4 family-associated protein 1", "gene_name": "Mrfap1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRPLDAVELAEPEEVEVLEPEEDFEQFLLPVIHEMREDIASLTRERGRAPVRNRGKLWEMDNMLIQIKTQVEASEESALNHLQGAGGAEPRGPRAEKAEEKAQEMAKMAEMLVQLVRRIEKSESS", "length": 125 }, "evidence": [ { "id": "Q3ZC61", "url": "https://omabrowser.org/oma/group/Q3ZC61/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9CQL7-1", "protein_name": "MORF4 family-associated protein 1", "gene_name": "Mrfap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPLDAVELAEPEEVEVLEPEEDFEQFLLPVIHEMREDIASLTRERGRAPARNRGKLWEMDNMLIQIKTQVEASEESALNHLQGAGGAEPRGPRAEKADEKAQEMAKMAEMLVQLVRRIEKSESS", "length": 125 }, "evidence": [ { "id": "Q3ZC61", "url": "https://omabrowser.org/oma/group/Q3ZC61/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y605-1", "protein_name": "MORF4 family-associated protein 1", "gene_name": "MRFAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPLDIVELAEPEEVEVLEPEEDFEQFLLPVINEMREDIASLTREHGRAYLRNRSKLWEMDNMLIQIKTQVEASEESALNHLQNPGDAAEGRAAKRCEKAEEKAKEIAKMAEMLVELVRRIEKSESS", "length": 127 }, "evidence": [ { "id": "Q3ZC61", "url": "https://omabrowser.org/oma/group/Q3ZC61/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC61", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC61", "url": "https://www.uniprot.org/uniprotkb/Q3ZC61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC61-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC61-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC61" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 53, "end_pos": 55 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC78-1", "uniprot_ac": "Q3ZC78", "uniprot_id": "CR032_BOVIN", "mass": { "chemical_mass": 8830.0, "monoisotopic_mass": 8830.0 }, "refseq": { "ac": "NP_001181991", "name": "UPF0729 protein C18orf32 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181991" }, "gene_names": [ { "name": "C24H18orf32", "type": "synonym", "evidence": [ { "id": "NP_001181991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181991" } ] } ], "protein_names": [ { "name": "UPF0729 protein C18orf32 homolog", "type": "recommended", "evidence": [ { "id": "Q3ZC78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78/entry#names_and_taxonomy" } ] }, { "name": "UPF0729 protein C18orf32 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181991" } ] } ], "function": [ { "annotation": "May activate the NF-kappa-B signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC78", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78#function" }, { "database": "UniProtKB", "id": "Q8TCD1", "url": "https://www.uniprot.org/uniprotkb/Q8TCD1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC78", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78", "locus": {} } ], "crossref": [ { "id": "Q3ZC78", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021334", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021334", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767921", "url": "https://www.ncbi.nlm.nih.gov/gene/767921", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767921", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767921", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SRIWPGK", "url": "https://omabrowser.org/oma/group/SRIWPGK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC78", "url": "https://www.orthodb.org/?gene=Q3ZC78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13456", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13456", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13456:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13456:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14975", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14975", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZC78", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC78-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVCIPCIVIPVLLWVYKKFLEPYIYPLISPFVSRMWPRKAIRETNDKNKGKVDYKGADINGLPTRGPTEMCDKKKD", "length": 76, "header": "sp|Q3ZC78-1|CR032_BOVIN Isoform 1 of UPF0729 protein C18orf32 homolog OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3ZC78-1" }, "isoforms": [ { "isoform_ac": "Q3ZC78-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78/entry#Q3ZC78-1", "sequence": { "sequence": "MVCIPCIVIPVLLWVYKKFLEPYIYPLISPFVSRMWPRKAIRETNDKNKGKVDYKGADINGLPTRGPTEMCDKKKD", "length": 76, "header": "sp|Q3ZC78-1|CR032_BOVIN Isoform 1 of UPF0729 protein C18orf32 homolog OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3ZC78-1" }, "locus": { "chromosome": "24", "start_pos": 49145793, "end_pos": 49144597, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028439.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028439.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028439.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028439.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767921", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767921", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FGN2-1", "protein_name": "Chromosome 18 open reading frame 32", "gene_name": "C18orf32", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVCIPCIVIPVLLWVYKKFLEPYIYPLISPFVSRMWPKKAVRDCNDKNKGKVDYKGADINGLPTRGPTEICDKKKD", "length": 76 }, "evidence": [ { "id": "Q3ZC78", "url": "https://omabrowser.org/oma/group/Q3ZC78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8TCD1-1", "protein_name": "UPF0729 protein C18orf32", "gene_name": "C18orf32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVCIPCIVIPVLLWIYKKFLEPYIYPLVSPFVSRIWPKKAIQESNDTNKGKVNFKGADMNGLPTKGPTEICDKKKD", "length": 76 }, "evidence": [ { "id": "Q3ZC78", "url": "https://omabrowser.org/oma/group/Q3ZC78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91WE4-1", "protein_name": "UPF0729 protein C18orf32 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVCIPCIVIPVLLWIFKKFLEPYIYPVVSRIWPKKAVQQSGDKNMSKVDCKGAGTNGLPTKGPTEVSDKKKD", "length": 72 }, "evidence": [ { "id": "Q3ZC78", "url": "https://omabrowser.org/oma/group/Q3ZC78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC78", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC78", "url": "https://www.uniprot.org/uniprotkb/Q3ZC78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 76, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC78" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCB6-1", "uniprot_ac": "Q3ZCB6", "uniprot_id": "PPDPF_BOVIN", "mass": { "chemical_mass": 12186.0, "monoisotopic_mass": 12186.0 }, "refseq": {}, "gene_names": [ { "name": "PPDPF", "type": "recommended", "evidence": [ { "id": "Q3ZCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6" } ] }, { "name": "EXDPF", "type": "synonym", "evidence": [ { "id": "Q3ZCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6" } ] } ], "protein_names": [ { "name": "Pancreatic progenitor cell differentiation and proliferation factor", "type": "recommended", "evidence": [ { "id": "Q3ZCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6/entry#names_and_taxonomy" } ] }, { "name": "Exocrine differentiation and proliferation factor", "type": "synonym", "evidence": [ { "id": "Q3ZCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable regulator of exocrine pancreas development.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPDPF", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6", "locus": { "chromosome": "13", "start_pos": 54136187, "end_pos": 54137833, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031800", "url": "https://www.ensembl.org/id/ENSBTAG00000031800" } ] } } ], "crossref": [ { "id": "Q3ZCB6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "506990", "url": "https://www.ncbi.nlm.nih.gov/gene/506990", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506990", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506990", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZCB6", "url": "https://www.orthodb.org/?gene=Q3ZCB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14572", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14572", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15060", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15060", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068762", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCB6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSAEYPGEAIPHHPGLPKADPGHWWASFFFGKSTLPFMATVLESPEHSESAQASTSTITCDLAQKAVGKQQPSGQPGKTTAGPRPE", "length": 116, "header": "sp|Q3ZCB6-1|PPDPF_BOVIN Isoform 1 of Pancreatic progenitor cell differentiation and proliferation factor OS=Bos taurus OX=9913 GN=PPDPF PE=3 SV=1 CANONICAL=Q3ZCB6-1" }, "isoforms": [ { "isoform_ac": "Q3ZCB6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6/entry#Q3ZCB6-1", "sequence": { "sequence": "MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSAEYPGEAIPHHPGLPKADPGHWWASFFFGKSTLPFMATVLESPEHSESAQASTSTITCDLAQKAVGKQQPSGQPGKTTAGPRPE", "length": 116, "header": "sp|Q3ZCB6-1|PPDPF_BOVIN Isoform 1 of Pancreatic progenitor cell differentiation and proliferation factor OS=Bos taurus OX=9913 GN=PPDPF PE=3 SV=1 CANONICAL=Q3ZCB6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506990", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 116, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCB6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9 ], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCC5-1", "uniprot_ac": "Q3ZCC5", "uniprot_id": "RBM18_BOVIN", "mass": { "chemical_mass": 21620.0, "monoisotopic_mass": 21620.0 }, "refseq": { "ac": "NP_001029496", "name": "probable RNA-binding protein 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029496" }, "gene_names": [ { "name": "RBM18", "type": "recommended", "evidence": [ { "id": "Q3ZCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" } ] }, { "name": "RBM18", "type": "synonym", "evidence": [ { "id": "NP_001029496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029496" } ] } ], "protein_names": [ { "name": "Probable RNA-binding protein 18", "type": "recommended", "evidence": [ { "id": "Q3ZCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 18", "type": "synonym", "evidence": [ { "id": "Q3ZCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5/entry#names_and_taxonomy" } ] }, { "name": "probable RNA-binding protein 18", "type": "synonym", "evidence": [ { "id": "NP_001029496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029496" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM18", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5", "locus": { "chromosome": "11", "start_pos": 93120914, "end_pos": 93138285, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016367", "url": "https://www.ensembl.org/id/ENSBTAG00000016367" } ] } } ], "crossref": [ { "id": "Q3ZCC5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCC5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016367", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12355", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12355", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508615", "url": "https://www.ncbi.nlm.nih.gov/gene/508615", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508615", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508615", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FACGRPL", "url": "https://omabrowser.org/oma/group/FACGRPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCC5", "url": "https://www.orthodb.org/?gene=Q3ZCC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029496", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCC5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCC5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLRLLQKFGTVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPAQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR", "length": 190, "header": "sp|Q3ZCC5-1|RBM18_BOVIN Isoform 1 of Probable RNA-binding protein 18 OS=Bos taurus OX=9913 GN=RBM18 PE=2 SV=1 CANONICAL=Q3ZCC5-1" }, "isoforms": [ { "isoform_ac": "Q3ZCC5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5/entry#Q3ZCC5-1", "sequence": { "sequence": "MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLRLLQKFGTVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPAQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR", "length": 190, "header": "sp|Q3ZCC5-1|RBM18_BOVIN Isoform 1 of Probable RNA-binding protein 18 OS=Bos taurus OX=9913 GN=RBM18 PE=2 SV=1 CANONICAL=Q3ZCC5-1" }, "locus": { "chromosome": "11", "start_pos": 93138269, "end_pos": 93121263, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021769.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021769.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021769.2", "url": "https://www.ensembl.org/id/ENSBTAP00000021769.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508615", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508615", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1P8BFV7-1", "protein_name": "Probable RNA-binding protein 18", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDTGGFVDEKGENRLYVGNLDLRINEASLIKMFSPYGKIISEDFLWHTRGPKKGEPRGYAFIQYSLKEEAELAKEKMHGRLACGRPLVVRLASEKHLEDSSHDHSKRSLPEGNRTRFVNGSSSGQMSRDEKVTAIKNKLKALEEDEKRDPKKQKI", "length": 155 }, "evidence": [ { "id": "Q3ZCC5", "url": "https://omabrowser.org/oma/group/Q3ZCC5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A286ZJA5-1", "protein_name": "Probable RNA-binding protein 18", "gene_name": "RBM18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGTVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIHCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPAQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR", "length": 190 }, "evidence": [ { "id": "Q3ZCC5", "url": "https://omabrowser.org/oma/group/Q3ZCC5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PBM8-1", "protein_name": "Probable RNA-binding protein 18", "gene_name": "rbm18", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQSAAETVENASILSGGSAQDGHRLWIGNIDPKITEYHLVKLLEKFGKVKQFDFLFHKSGPLEGQPRGYCFVNFHTKEEAERAIQCLNGKLALSKKLVVRWAHAQRFEPFRGEKNMPASLEPSSSEAEDLPTSLSVNAKIRAIEAKLQMMEENPDDYSGPSAYTYNKPPDKREKRSQPYHKHFRKHRR", "length": 188 }, "evidence": [ { "id": "Q3ZCC5", "url": "https://omabrowser.org/oma/group/Q3ZCC5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96H35-1", "protein_name": "Probable RNA-binding protein 18", "gene_name": "RBM18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPTQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR", "length": 190 }, "evidence": [ { "id": "Q3ZCC5", "url": "https://omabrowser.org/oma/group/Q3ZCC5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR83-1", "protein_name": "Probable RNA-binding protein 18", "gene_name": "Rbm18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPAQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR", "length": 190 }, "evidence": [ { "id": "Q3ZCC5", "url": "https://omabrowser.org/oma/group/Q3ZCC5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCC5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 190, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCC5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCC5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC5" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 25, "end_pos": 106, "start_aa": "His", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 136, "end_pos": 138 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCD2-1", "uniprot_ac": "Q3ZCD2", "uniprot_id": "TMM54_BOVIN", "mass": { "chemical_mass": 23646.0, "monoisotopic_mass": 23646.0 }, "refseq": { "ac": "NP_001029536", "name": "transmembrane protein 54", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029536" }, "gene_names": [ { "name": "TMEM54", "type": "recommended", "evidence": [ { "id": "Q3ZCD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2" } ] }, { "name": "TMEM54", "type": "synonym", "evidence": [ { "id": "NP_001029536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029536" } ] } ], "protein_names": [ { "name": "Transmembrane protein 54", "type": "recommended", "evidence": [ { "id": "Q3ZCD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 54", "type": "synonym", "evidence": [ { "id": "NP_001029536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029536" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM54", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2", "locus": { "chromosome": "2", "start_pos": 120780411, "end_pos": 120773204, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008331", "url": "https://www.ensembl.org/id/ENSBTAG00000008331" } ] } } ], "crossref": [ { "id": "Q3ZCD2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008331", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008331", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509773", "url": "https://www.ncbi.nlm.nih.gov/gene/509773", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509773", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509773", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVAGPHD", "url": "https://omabrowser.org/oma/group/YVAGPHD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCD2", "url": "https://www.orthodb.org/?gene=Q3ZCD2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029536", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCD2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVAAPNDAVALQYCVVDILSVTSAIVVITSGISVIVLSRYLPSIPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 222, "header": "sp|Q3ZCD2-1|TMM54_BOVIN Isoform 1 of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=2 SV=1 CANONICAL=Q3ZCD2-1" }, "isoforms": [ { "isoform_ac": "Q3ZCD2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2/entry#Q3ZCD2-1", "sequence": { "sequence": "MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVAAPNDAVALQYCVVDILSVTSAIVVITSGISVIVLSRYLPSIPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 222, "header": "sp|Q3ZCD2-1|TMM54_BOVIN Isoform 1 of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=2 SV=1 CANONICAL=Q3ZCD2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509773", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509773", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LA99-1", "protein_name": "Transmembrane protein 54", "gene_name": "TMEM54", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCQRLGGLSASDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVTAPHDAVALQYCVVNILSVTSAIVVITSGIAAIVLSRYLPSSPLRWTVFSSNVACALLSLTCALGLLASIAVTFATQGRALLAACTFGSPELLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRCAQLAHQLLELRPWLGKSSHHMIQESPEPVEDRDLPSCTSSGPLTL", "length": 222 }, "evidence": [ { "id": "Q3ZCD2", "url": "https://omabrowser.org/oma/group/Q3ZCD2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q494T4-1", "protein_name": "Transmembrane protein 54", "gene_name": "Tmem54", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCLRIGGLNVDEFRKLLMKTGLVLVVLGHVSFIAAAVLHGTMLRFVATTRDAVVLQYCVVDILSVTSAIVVILAGISAVILSRYLPSTPLRWTVFSLSVACALLSLTCALGLLASIAVTFATKGRALLAPCTFENTELPTLAPDCPFDPTRIYSSSLCLWAISLIFCLAESMSAVRCAQLVHRLLELRPWWGKSCHHTIQASPEPLDGHDLLSCTS", "length": 216 }, "evidence": [ { "id": "Q3ZCD2", "url": "https://omabrowser.org/oma/group/Q3ZCD2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q969K7-1", "protein_name": "Transmembrane protein 54", "gene_name": "TMEM54", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVVNILSVTSAIVVITSGIAAIVLSRYLPSTPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGKALLAACTFGSSELLALAPDCPFDPTRIYSSSLCLWGIALVLCVAENVFAVRCAQLTHQLLELRPWWGKSSHHMMRENPELVEGRDLLSCTSSEPLTL", "length": 222 }, "evidence": [ { "id": "Q3ZCD2", "url": "https://omabrowser.org/oma/group/Q3ZCD2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7S1-1", "protein_name": "Transmembrane protein 54", "gene_name": "Tmem54", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCLRIGSLNVDEFRKVLMKTGLVLVVLGHVSFIAAAVLHGTMLRFVATTSDAVVLQYCAVDILSVTSAIVVIVAGISTIVLSRYLPSTPLRWTVFSLSVACALLSLTCALGLLASIAVTFATKGRALLAACTFENPELPTLAPDCPFDPTRIYSSSLCLWAISLIFCLAESMSAVRCAQLMHGLLELRPWWGKSCHHTIQASPEPLDAHDLLSCASSCS", "length": 219 }, "evidence": [ { "id": "Q3ZCD2", "url": "https://omabrowser.org/oma/group/Q3ZCD2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCD2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 222, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCD2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCD2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCF2-1", "uniprot_ac": "Q3ZCF2", "uniprot_id": "MED10_BOVIN", "mass": { "chemical_mass": 15688.0, "monoisotopic_mass": 15688.0 }, "refseq": { "ac": "NP_001029928", "name": "mediator of RNA polymerase II transcription subunit 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029928" }, "gene_names": [ { "name": "MED10", "type": "recommended", "evidence": [ { "id": "Q3ZCF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ] }, { "name": "MED10", "type": "synonym", "evidence": [ { "id": "NP_001029928", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029928" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 10", "type": "recommended", "evidence": [ { "id": "Q3ZCF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 10", "type": "synonym", "evidence": [ { "id": "Q3ZCF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 10", "type": "synonym", "evidence": [ { "id": "NP_001029928", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029928" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED10", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2", "locus": { "chromosome": "20", "start_pos": 66825991, "end_pos": 66817798, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008130", "url": "https://www.ensembl.org/id/ENSBTAG00000008130" } ] } } ], "crossref": [ { "id": "Q3ZCF2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008130", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008130", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614276", "url": "https://www.ncbi.nlm.nih.gov/gene/614276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYQRAKM", "url": "https://omabrowser.org/oma/group/QYQRAKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCF2", "url": "https://www.orthodb.org/?gene=Q3ZCF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09748", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09748", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9841922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029928", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCF2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS", "length": 135, "header": "sp|Q3ZCF2-1|MED10_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 10 OS=Bos taurus OX=9913 GN=MED10 PE=2 SV=1 CANONICAL=Q3ZCF2-1" }, "isoforms": [ { "isoform_ac": "Q3ZCF2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2/entry#Q3ZCF2-1", "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS", "length": 135, "header": "sp|Q3ZCF2-1|MED10_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 10 OS=Bos taurus OX=9913 GN=MED10 PE=2 SV=1 CANONICAL=Q3ZCF2-1" }, "locus": { "chromosome": "20", "start_pos": 66825468, "end_pos": 66817856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010690.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010690.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010690.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010690.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614276", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9841922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "resource": "Reactome", "description": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4F6T0-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "MED10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDQPPS", "length": 135 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A7K6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "Med10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS", "length": 135 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q06213-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "NUT2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPEATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH", "length": 157 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q0VIA1-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "med10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQTGLNQKLNFMITGLQDIEKCRQQLHDINVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLTKFKSLLISELGKVFPEEMAKYKAIHGDDPPS", "length": 134 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BTT4-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "MED10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS", "length": 135 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXU0-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "Med10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS", "length": 135 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GYU7-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "MED10", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAPLENLETQLEMFIENVRQIRIIVSDFQPQGQNVLNQKINSLVTGLQEIDKLRSQVQDVYVPFEVFFDYIDQDKNPQLYTKDCVEKALAKNEEVKGKIEGLKKFKTNLLLELYKTFPNEMNNYRAYRKDSM", "length": 133 }, "evidence": [ { "id": "Q3ZCF2", "url": "https://omabrowser.org/oma/group/Q3ZCF2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 135, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCF2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCF2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCK8-1", "uniprot_ac": "Q3ZCK8", "uniprot_id": "COA5_BOVIN", "mass": { "chemical_mass": 8417.0, "monoisotopic_mass": 8417.0 }, "refseq": { "ac": "NP_001181953", "name": "cytochrome c oxidase assembly factor 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953" }, "gene_names": [ { "name": "COA5", "type": "recommended", "evidence": [ { "id": "Q3ZCK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ] }, { "name": "C11H2ORF64", "type": "synonym", "evidence": [ { "id": "NP_001181953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953" } ] }, { "name": "COA5", "type": "synonym", "evidence": [ { "id": "NP_001181953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly factor 5", "type": "recommended", "evidence": [ { "id": "Q3ZCK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8/entry#names_and_taxonomy" } ] }, { "name": "Uncharacterized protein C2orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953" } ] }, { "name": "cytochrome c oxidase assembly factor 5", "type": "synonym", "evidence": [ { "id": "NP_001181953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953" } ] } ], "function": [ { "annotation": "Assembly factor for cytochrome c oxidase (respiratory chain complex IV). Stabilizes an early formation of cytochrome c oxidase assembly factors, until it is displaced by the metallochaperone copper-delivery protein COX17.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8#function" }, { "database": "UniProtKB", "id": "Q86WW8", "url": "https://www.uniprot.org/uniprotkb/Q86WW8#function" }, { "database": "UniProtKB", "id": "A0AAF6Z111", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z111#function" }, { "database": "UniProtKB", "id": "ARBA00094211", "url": "https://www.uniprot.org/uniprotkb/ARBA00094211#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COA5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8", "locus": { "chromosome": "11", "start_pos": 3790084, "end_pos": 3825106, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014873", "url": "https://www.ensembl.org/id/ENSBTAG00000014873" } ] } } ], "crossref": [ { "id": "Q3ZCK8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614794", "url": "https://www.ncbi.nlm.nih.gov/gene/614794", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614794", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614794", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KKTPKEC", "url": "https://omabrowser.org/oma/group/KKTPKEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCK8", "url": "https://www.orthodb.org/?gene=Q3ZCK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28627", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28627", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28627:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28627:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10203", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10203", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001181953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181953", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z111", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z111", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z111-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z111-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRYYEDKPEGGACAGVKEDLGLCLLQSDCVLKEGKSPRQCLKEGNCKALKYSFFECKRSMLDARSRFRGRKGY", "length": 74, "header": "sp|Q3ZCK8-1|COA5_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 5 OS=Bos taurus OX=9913 GN=COA5 PE=3 SV=1 CANONICAL=Q3ZCK8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z111-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8/entry#A0AAF6Z111-1", "sequence": { "sequence": "MWGRKLPEEKADQRARVARRRGRRQASPGAPRRRPPASHTPATTAEQPTQQPLGQLPSPLRQPRRGRVASRDPQTPRAIPFALRLSPRAHRKWLLPLFFRFRPPQRHWRPEESGPSRKERVEAAASWRRSHAPEGKSPRQCLKEGNCKALKYSFFECKRSMLDARSRFRGRKGY", "length": 174, "header": "tr|A0AAF6Z111-1|A0AAF6Z111_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 5 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=Q3ZCK8-1" }, "locus": { "chromosome": "11", "start_pos": 3824516, "end_pos": 3790569, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019802.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019802.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019802.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019802.5" } ] } }, { "isoform_ac": "Q3ZCK8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8/entry#Q3ZCK8-1", "sequence": { "sequence": "MPRYYEDKPEGGACAGVKEDLGLCLLQSDCVLKEGKSPRQCLKEGNCKALKYSFFECKRSMLDARSRFRGRKGY", "length": 74, "header": "sp|Q3ZCK8-1|COA5_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 5 OS=Bos taurus OX=9913 GN=COA5 PE=3 SV=1 CANONICAL=Q3ZCK8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ], "site_lbl": "Ser37" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614794", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614794", "resource": "KEGG Pathway" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MXT5-1", "protein_name": "Cytochrome c oxidase assembly factor 5", "gene_name": "LOC100766959", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPRYYEDKVEGGACAGVKEDLGACLLQSACVLQEGKSPRQCLKEGYCRALQYSFFECKRSMLDTRSRFRGRKGY", "length": 74 }, "evidence": [ { "id": "Q3ZCK8", "url": "https://omabrowser.org/oma/group/Q3ZCK8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q86WW8-1", "protein_name": "Cytochrome c oxidase assembly factor 5", "gene_name": "COA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKYYEDKPQGGACAGLKEDLGACLLQSDCVVQEGKSPRQCLKEGYCNSLKYAFFECKRSVLDNRARFRGRKGY", "length": 74 }, "evidence": [ { "id": "Q3ZCK8", "url": "https://omabrowser.org/oma/group/Q3ZCK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99M07-1", "protein_name": "Cytochrome c oxidase assembly factor 5", "gene_name": "Coa5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRYYEDKPEGGACAGVKEDLGACLLQSACVLQEGKSPRQCLKEGNCRALQYSFFECKRSMLDARSRFRGRKGY", "length": 74 }, "evidence": [ { "id": "Q3ZCK8", "url": "https://omabrowser.org/oma/group/Q3ZCK8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 74, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCK8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000255", "start_pos": 27, "end_pos": 65, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZCK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx10C motif", "eco_id": "ECO_0000255", "start_pos": 30, "end_pos": 41, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZCK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK8" }, { "id": "PRU01150", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01150" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cx9C motif", "eco_id": "ECO_0000255", "start_pos": 47, "end_pos": 57, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 37 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZRW9-1", "uniprot_ac": "Q3ZRW9", "uniprot_id": "CLUL1_BOVIN", "mass": { "chemical_mass": 53950.0, "monoisotopic_mass": 53950.0 }, "refseq": { "ac": "NP_001029692", "name": "clusterin-like protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692" }, "gene_names": [ { "name": "CLUL1", "type": "recommended", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9" } ] }, { "name": "CLUL1", "type": "synonym", "evidence": [ { "id": "NP_001029692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692" } ] } ], "protein_names": [ { "name": "Clusterin-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9/entry#names_and_taxonomy" } ] }, { "name": "clusterin-like 1 (retinal)", "type": "synonym", "evidence": [ { "id": "NP_001029692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692" } ] }, { "name": "clusterin-like protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692" } ] }, { "name": "clusterin-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZRW9", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLUL1", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9", "locus": { "chromosome": "24", "start_pos": 35548349, "end_pos": 35518976, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014012", "url": "https://www.ensembl.org/id/ENSBTAG00000014012" } ] } } ], "crossref": [ { "id": "Q3ZRW9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZRW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "516801", "url": "https://www.ncbi.nlm.nih.gov/gene/516801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516801", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZRW9", "url": "https://www.orthodb.org/?gene=Q3ZRW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10970", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10970", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10970:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10970:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029692", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZRW9", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZRW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPPILVFIVYLLQLRDCQCAPTGKDRTSIREDPKGFSKAGEIDVDEEVKKALIGMKQMKILMERREEEHSKLMRTLKKCREEKQEALKLMNEVQEHLEEEERLCQVSLMDSWDECKSCLESDCMRFYTTCQSSWSSMKSTIERVFRKIYQFLFPFHEDDEKELPVGEKFTEEDVQLMQIENVFSQLTVDVGFLYNMSFHVFKQMQQEFDLAFQSYFMSDTDSMEPYFFPAFSKEPAKKAHPMQSWDIPSFFQLFCNFSLSVYQSVSATVTEMLKATEDLSKQDKDSAHGGPSSTTWPVRGRGLCGEPGQNSSECLQFHARCQKCQDYLWADCPAVPELYTKADEALELVNISNQQYAQVLQMTQHHLEDTTYLMEKMREQFGWVTELASQTPGSENIFSFIKVVPGVHEGNFSKQDEKMIDISILPSSNFTLTIPLEESAESSDFISYMLAKAVQHFKEHFKSW", "length": 465, "header": "sp|Q3ZRW9-1|CLUL1_BOVIN Isoform 1 of Clusterin-like protein 1 OS=Bos taurus OX=9913 GN=CLUL1 PE=2 SV=1 CANONICAL=Q3ZRW9-1" }, "isoforms": [ { "isoform_ac": "Q3ZRW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9/entry#Q3ZRW9-1", "sequence": { "sequence": "MKPPILVFIVYLLQLRDCQCAPTGKDRTSIREDPKGFSKAGEIDVDEEVKKALIGMKQMKILMERREEEHSKLMRTLKKCREEKQEALKLMNEVQEHLEEEERLCQVSLMDSWDECKSCLESDCMRFYTTCQSSWSSMKSTIERVFRKIYQFLFPFHEDDEKELPVGEKFTEEDVQLMQIENVFSQLTVDVGFLYNMSFHVFKQMQQEFDLAFQSYFMSDTDSMEPYFFPAFSKEPAKKAHPMQSWDIPSFFQLFCNFSLSVYQSVSATVTEMLKATEDLSKQDKDSAHGGPSSTTWPVRGRGLCGEPGQNSSECLQFHARCQKCQDYLWADCPAVPELYTKADEALELVNISNQQYAQVLQMTQHHLEDTTYLMEKMREQFGWVTELASQTPGSENIFSFIKVVPGVHEGNFSKQDEKMIDISILPSSNFTLTIPLEESAESSDFISYMLAKAVQHFKEHFKSW", "length": 465, "header": "sp|Q3ZRW9-1|CLUL1_BOVIN Isoform 1 of Clusterin-like protein 1 OS=Bos taurus OX=9913 GN=CLUL1 PE=2 SV=1 CANONICAL=Q3ZRW9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 196, "start_aa": "Asn", "end_pos": 196, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn196", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 257, "start_aa": "Asn", "end_pos": 257, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 311, "start_aa": "Asn", "end_pos": 311, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn311", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 351, "start_aa": "Asn", "end_pos": 351, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn351", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 412, "start_aa": "Asn", "end_pos": 412, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn412", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 430, "start_aa": "Asn", "end_pos": 430, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn430", "evidence": [ { "id": "Q3ZRW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516801", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516801", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZRW9", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZRW9", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "Q3ZRW9", "url": "https://www.uniprot.org/uniprotkb/Q3ZRW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZRW9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 465, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZRW9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZRW9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 196, 257, 311, 351, 412, 430 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 412, "end_pos": 414 }, { "start_pos": 430, "end_pos": 432 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q50JB9-1", "uniprot_ac": "Q50JB9", "uniprot_id": "Q50JB9_BOVIN", "mass": { "chemical_mass": 7614.0, "monoisotopic_mass": 7614.0 }, "refseq": { "ac": "NP_001108334", "name": "beta-defensin 103B precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" }, "gene_names": [ { "name": "LOC789175", "type": "recommended", "evidence": [ { "id": "Q50JB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ] }, { "name": "DEFB103A", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "DEFB103B", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "DEFB103", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "DEFB300", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "LOC789175", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] } ], "protein_names": [ { "name": "Beta-defensin-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "Q50JB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q50JB9/entry#names_and_taxonomy" } ] }, { "name": "beta defensin 103", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "beta-defensin 103B precursor", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "beta-defensin 103B", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "beta-defensin 300", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "defensin, beta 103A", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] }, { "name": "defensin, beta 103B", "type": "synonym", "evidence": [ { "id": "NP_001108334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ] } ], "function": [ { "annotation": "Data indicate that two types of deletion (4 bp and 8 bp) were identified in the 5'UTR of beta-defensin gene DEFB103 sequence.", "evidence": [ { "database": "RefSeq", "id": "NP_001108334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" }, { "database": "PubMed", "id": "25173739", "url": "https://glygen.org/publication/PubMed/25173739" } ] }, { "annotation": "Expression of the bovine DEFB103 gene was surveyed in 27 tissues and transcript was most abundant in tissues with stratified squamous epithelium.", "evidence": [ { "database": "RefSeq", "id": "NP_001108334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" }, { "database": "PubMed", "id": "26299200", "url": "https://glygen.org/publication/PubMed/26299200" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC789175", "url": "https://www.uniprot.org/uniprotkb/Q50JB9", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000052579", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052579", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789175", "url": "https://www.ncbi.nlm.nih.gov/gene/789175", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789175", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789175", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RETQIGH", "url": "https://omabrowser.org/oma/group/RETQIGH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q50JB9", "url": "https://www.orthodb.org/?gene=Q50JB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20515:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20515:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1461957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1461973", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461973", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001108334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q50JB9-1", "url": "https://www.uniprot.org/uniprotkb/Q50JB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLYYLLFALLFLFLLPVPGNGGIISGLQRYYCKIRSGRCALIGCLPKEEQIGRCSLSGRKCCRKKK", "length": 67, "header": "tr|Q50JB9-1|Q50JB9_BOVIN Isoform 1 of Beta-defensin-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC789175 PE=4 SV=1 CANONICAL=Q50JB9-1" }, "isoforms": [ { "isoform_ac": "Q50JB9-1", "url": "https://www.uniprot.org/uniprotkb/Q50JB9/entry#Q50JB9-1", "sequence": { "sequence": "MRLYYLLFALLFLFLLPVPGNGGIISGLQRYYCKIRSGRCALIGCLPKEEQIGRCSLSGRKCCRKKK", "length": 67, "header": "tr|Q50JB9-1|Q50JB9_BOVIN Isoform 1 of Beta-defensin-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC789175 PE=4 SV=1 CANONICAL=Q50JB9-1" }, "locus": { "chromosome": "27", "start_pos": 6025070, "end_pos": 6024210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072863.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072863.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061044.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of a new non-coding exon and haplotype variability in the cattle DEFB103 gene.", "journal": "Gene", "date": "2014-11-10", "authors": "Mirabzadeh-Ardakani Ali, Griebel Philip, Schmutz Sheila M", "evidence": [ { "database": "RefSeq", "id": "NP_001108334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ], "reference": [ { "type": "PubMed", "id": "25173739", "url": "https://glygen.org/publication/PubMed/25173739" } ] }, { "title": "Tissue- and age-dependent expression of the bovine DEFB103 gene and protein.", "journal": "Cell and tissue research", "date": "2016-02", "authors": "Mirabzadeh-Ardakani Ali, Solie Jay, Gonzalez-Cano Patricia, Schmutz Sheila M, Griebel Philip J", "evidence": [ { "database": "RefSeq", "id": "NP_001108334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108334" } ], "reference": [ { "type": "PubMed", "id": "26299200", "url": "https://glygen.org/publication/PubMed/26299200" } ] } ], "pathway": [ { "id": "bta:789175", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789175", "resource": "KEGG Pathway" }, { "id": "R-BTA-1461957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461957", "resource": "Reactome", "description": "Beta defensins" }, { "id": "R-BTA-1461973", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461973", "resource": "Reactome", "description": "Defensins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IJZ9-1", "protein_name": "Beta-defensin 14", "gene_name": "LOC100769521", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRLHYLLFAFLILFLVPAPGNAFIQRTIQKLFCRLRGGRCALFSCLAREEQIGQCSSRGRKCCRTKKK", "length": 68 }, "evidence": [ { "id": "Q50JB9", "url": "https://omabrowser.org/oma/group/Q50JB9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P81534-1", "protein_name": "Beta-defensin 103", "gene_name": "DEFB103A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK", "length": 67 }, "evidence": [ { "id": "Q50JB9", "url": "https://omabrowser.org/oma/group/Q50JB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q32ZH7-1", "protein_name": "Beta-defensin 14", "gene_name": "Defb14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLHYLLFVFLILFLVPAPGDTFIPKSLRRFFCRVRGGRCAILNCLGKEEQIGRCSNRGQKCCRKKK", "length": 67 }, "evidence": [ { "id": "Q50JB9", "url": "https://omabrowser.org/oma/group/Q50JB9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TNV9-1", "protein_name": "Beta-defensin 14", "gene_name": "Defb14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLHYLLFVFLILFLVPAPGDAFLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK", "length": 67 }, "evidence": [ { "id": "Q50JB9", "url": "https://omabrowser.org/oma/group/Q50JB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chemoattractant activity", "id": "GO:0042056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042056", "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "pmid": "" }, { "name": "CCR6 chemokine receptor binding", "id": "GO:0031731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031731", "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "Q50JB9", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q50JB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q50JB9" }, { "id": "PF00711", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00711" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-defensin-like", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 64, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q52QI2-1", "uniprot_ac": "Q52QI2", "uniprot_id": "RTL1_BOVIN", "mass": { "chemical_mass": 151448.0, "monoisotopic_mass": 151448.0 }, "refseq": { "ac": "NP_001181949", "name": "retrotransposon-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" }, "gene_names": [ { "name": "RTL1", "type": "recommended", "evidence": [ { "id": "Q52QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ] }, { "name": "PEG11", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" }, { "id": "Q52QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ] }, { "name": "RTL1", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" } ] } ], "protein_names": [ { "name": "Retrotransposon-like protein 1", "type": "recommended", "evidence": [ { "id": "Q52QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q52QI2/entry#names_and_taxonomy" } ] }, { "name": "Paternally expressed gene 11 protein homolog", "type": "synonym", "evidence": [ { "id": "Q52QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q52QI2/entry#names_and_taxonomy" } ] }, { "name": "Retrotransposon-derived protein PEG11", "type": "synonym", "evidence": [ { "id": "Q52QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q52QI2/entry#names_and_taxonomy" } ] }, { "name": "paternally expressed gene 11 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" } ] }, { "name": "retrotransposon-derived protein PEG11", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" } ] }, { "name": "retrotransposon-like 1", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" } ] }, { "name": "retrotransposon-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001181949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949" } ] } ], "function": [ { "annotation": "Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.", "evidence": [ { "database": "UniProtKB", "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTL1", "url": "https://www.uniprot.org/uniprotkb/Q52QI2", "locus": { "chromosome": "21", "start_pos": 65777092, "end_pos": 65800921, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046585", "url": "https://www.ensembl.org/id/ENSBTAG00000046585" } ] } } ], "crossref": [ { "id": "Q52QI2", "url": "https://alphafold.ebi.ac.uk/entry/Q52QI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046585", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046585", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00303", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00303", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01647", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01647", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "606737", "url": "https://www.ncbi.nlm.nih.gov/gene/606737", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:606737", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:606737", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EFIVLCQ", "url": "https://omabrowser.org/oma/group/EFIVLCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q52QI2", "url": "https://www.orthodb.org/?gene=Q52QI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15503", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15503", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15503:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15503:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17919", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17919", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181949", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q52QI2-1", "url": "https://www.uniprot.org/uniprotkb/Q52QI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEPSEDSFETMMERKNPSSKQMESSEGSSNTTVETPPGGRVEAAGLASGLAQEMGEQSIDLRQDMEEPSSGPHREIKDPPNDLLQDLEESCEGSHLEEGGPFGGAPGEMEEEEDNPWESQEDQDYYTDLAESEEDESPEEPDSSTVEVMGMVRSIISLYFRMQDLREQQRVAEEILMNAINKGQLPNPKQFSGDRREYHEFIVLCQLILQSYPRVFCNDRLRVGYIISHLSGMAMEWAGDLLERESSVIDDFPAFLEAMNDTFEYRQALRVAEDAMFNLRQGDRAAIEYINEFQSLVPTLGWPDEVLQAHLCQGLKEDIRQYLFRIPQPNSLENLITLVLQIEDKLAERRAILRLLPESRPRHLTWLDSPVPERWTVSTWLPNEFHPGIKRNHLFLLLLVRVNPYHSVAVQALVDSGATSNYMDEGFAQEHYVELYQKPYAESVQTADGSLVGNEPVWLYTEPLVCLHQNHQESLEFDIVASSKFSVVLGIKWLQLHAPEIDWVKGRCTFHSPYCLKNCFRPPPPCIALEHHAVSLLPGLPHQYSDLADVFNPKEADEETSDQPSSDGSDDLSESEPSELQQAGDSDQSEETFYDCASTAPWEPVGAGTQEKAKQEEFWDPKDMLTSRHDYVQMIPELFDQLHGATWFTKLELRGTIVEESMSIHQTEDVWKVAFGLELQDMASYQPFLICADPIIPQGVIHFILKDMIGLFVVSYGQDVLVYSMSQEEHYHHVRQVLVRFRYHYVYCSLQRSQFHRHTAEFLGFVVTPKGVKLNKSIVSTITGYPTPGSRKSLRNLMEFAFPYRHFVERFADITEPLVRQLQADLPFYWGDEEQEAFVGLKRAFRKAPLLYHPKPQNQFYLQTGVTKTSLHASLIQMDKRTGKKVCCAFYSRNISPMEVEASPAEMKILPIRAAFMVWCRYLENTEEPIMILLNKEDLASLNNDRLTVLLPGHWVFFFTHFNFDVMEMPSSEDDQPLPRRQRLGERAQQRRVATTTRPTMLVTMPAPTGDQSPESEDEEESEGALHPDEPNGQNLQQGYLALIPVDQIFNSFLAHFSMAQIRAVLLHFYRSLLFWKNLLAMAALLVMLRFRRRLALLPAPAADPARPPQRRSLRLFLDASLLTSSGIATAVTQLFTQMPPLVGTNALPAEELAELFLGPGPWQLNALRGLQMTPRFWQMLCQFFGIRGRALEGTQTHPSPHQSLAPHVEGDEYVVLREALQDDLQRFRQCGLHDGLQDTSQDAQDDVWALRPRQHLPTEAEVLARLTYIRSTQGGSVVIHRELTARDLIDFLASVYTQALPTLVEASPPREGATLEELPSDADEDAGLD", "length": 1331, "header": "sp|Q52QI2-1|RTL1_BOVIN Isoform 1 of Retrotransposon-like protein 1 OS=Bos taurus OX=9913 GN=RTL1 PE=2 SV=2 CANONICAL=Q52QI2-1" }, "isoforms": [ { "isoform_ac": "Q52QI2-1", "url": "https://www.uniprot.org/uniprotkb/Q52QI2/entry#Q52QI2-1", "sequence": { "sequence": "MMEPSEDSFETMMERKNPSSKQMESSEGSSNTTVETPPGGRVEAAGLASGLAQEMGEQSIDLRQDMEEPSSGPHREIKDPPNDLLQDLEESCEGSHLEEGGPFGGAPGEMEEEEDNPWESQEDQDYYTDLAESEEDESPEEPDSSTVEVMGMVRSIISLYFRMQDLREQQRVAEEILMNAINKGQLPNPKQFSGDRREYHEFIVLCQLILQSYPRVFCNDRLRVGYIISHLSGMAMEWAGDLLERESSVIDDFPAFLEAMNDTFEYRQALRVAEDAMFNLRQGDRAAIEYINEFQSLVPTLGWPDEVLQAHLCQGLKEDIRQYLFRIPQPNSLENLITLVLQIEDKLAERRAILRLLPESRPRHLTWLDSPVPERWTVSTWLPNEFHPGIKRNHLFLLLLVRVNPYHSVAVQALVDSGATSNYMDEGFAQEHYVELYQKPYAESVQTADGSLVGNEPVWLYTEPLVCLHQNHQESLEFDIVASSKFSVVLGIKWLQLHAPEIDWVKGRCTFHSPYCLKNCFRPPPPCIALEHHAVSLLPGLPHQYSDLADVFNPKEADEETSDQPSSDGSDDLSESEPSELQQAGDSDQSEETFYDCASTAPWEPVGAGTQEKAKQEEFWDPKDMLTSRHDYVQMIPELFDQLHGATWFTKLELRGTIVEESMSIHQTEDVWKVAFGLELQDMASYQPFLICADPIIPQGVIHFILKDMIGLFVVSYGQDVLVYSMSQEEHYHHVRQVLVRFRYHYVYCSLQRSQFHRHTAEFLGFVVTPKGVKLNKSIVSTITGYPTPGSRKSLRNLMEFAFPYRHFVERFADITEPLVRQLQADLPFYWGDEEQEAFVGLKRAFRKAPLLYHPKPQNQFYLQTGVTKTSLHASLIQMDKRTGKKVCCAFYSRNISPMEVEASPAEMKILPIRAAFMVWCRYLENTEEPIMILLNKEDLASLNNDRLTVLLPGHWVFFFTHFNFDVMEMPSSEDDQPLPRRQRLGERAQQRRVATTTRPTMLVTMPAPTGDQSPESEDEEESEGALHPDEPNGQNLQQGYLALIPVDQIFNSFLAHFSMAQIRAVLLHFYRSLLFWKNLLAMAALLVMLRFRRRLALLPAPAADPARPPQRRSLRLFLDASLLTSSGIATAVTQLFTQMPPLVGTNALPAEELAELFLGPGPWQLNALRGLQMTPRFWQMLCQFFGIRGRALEGTQTHPSPHQSLAPHVEGDEYVVLREALQDDLQRFRQCGLHDGLQDTSQDAQDDVWALRPRQHLPTEAEVLARLTYIRSTQGGSVVIHRELTARDLIDFLASVYTQALPTLVEASPPREGATLEELPSDADEDAGLD", "length": 1331, "header": "sp|Q52QI2-1|RTL1_BOVIN Isoform 1 of Retrotransposon-like protein 1 OS=Bos taurus OX=9913 GN=RTL1 PE=2 SV=2 CANONICAL=Q52QI2-1" }, "locus": { "chromosome": "21", "start_pos": 65782456, "end_pos": 65778464, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095940.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095940.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085277.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 788, "start_aa": "Thr", "end_pos": 788, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr788", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:606737", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:606737", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NKG5-1", "protein_name": "Retrotransposon-like protein 1", "gene_name": "RTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEPSEDSFETMMEHKNPSSKQMESSEGSSNTTEATSGSGVRGEAGPASGPAQEKKEPPSGPLQEMEELPTDLLQDMEEPSSGPRKEIEDPPNDLLQDLEESCNGSHQARGDPLSGASDRMKEASVNPSGAREEQEAHTDLKESGREETPQEQNQTEHSTAELMAMVRSIISLYFRMQDLKEQQRVAEEILIKGINAGQLPAPKHFSGDRREFHEFIVLCQLTLQSYPRMFYNDRLRVGYVINHLSGLALEWAKALLQENSPLIGDFPAFLEAMSEVFEYRQALRVAEEAMFTIRQGGRSATEYIDEFQSLVPILGWPDEVLQAHLCQGLNEEIRHYLFRVPQPDSLDSLIVLILQIEEKLAERRAMLRLPPEARPRNLTWIDSPAPERWMVSSWLPSEVHPDINRAHLFLLLMVRVNPYHSVAVQALVDSGADGNFMDEKFAQEHYVELYEKPYPQPVQSVDGSLIGNEPVWLYTEPLVCIHQNHQESIEFDIVPSPNFSVVLGIRWLRVHAPEVDWIKGRCTFHSPYCLKNCFRPPPPCIALERHGMSLLPGLPHPYSDLADVFNPKEADDETSDQPSSDGSDDLSESEPSELQQAGDSDHSETFYECPSTAPWEPVGARMQERARLQEEYWDLQDMLTNRQDYIQMIPELFDQLHGAEWFTKLELRGTIVEESVNGHRTEDVWKAAFGLELEEMKSYQPFALSPDPIIPQNVIHFILKDMLGFFVLSYGQEVLIYSMSQEEHLHHVRQVLVRFRHHNVYCSLDKSQFHRQTVEFLGFVVTPKGVKLNKNVMTIITGYPTPGSKLSLRNFIEFVFPYRHFVERFSIIAEPLVRQLLSSYQFYWGVEEQEAFECLKRAFRKAPLLHHPKPQNPFYLETGVTGTALHASLIQIDDQTGKRACCAFYSRNISPIEVEYSQAEMKILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFDVMELPEQDGGRALPPVRNLRWRRAFQRNTAARQTLLLASRGFPRDPSTESGEEENEEQDELNEQILRQELLAMIPIDQILNSFLAHFSMAQIRAVILHFFRGLLYWKNTLALAAILVLLRVRQCLSLRPAPAMRVARPQPQRSLRLILDSSLIAGSSITTAITQLLTQMPALVGANTIPAQELAELFLGPGRWQRNALHSQAHRGLQFTPGFWLTLCEFFGVRVTPQEGHLPALRQNRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDKQDNDVQEAPPSHTAATHPPRPRHLMDPQVLEFLGSRLLHIHSADGQLHLLSREQAARALSQFLTLIYRRALPIPAWESQPREQARLEELPDEDEDANLD", "length": 1358 }, "evidence": [ { "id": "Q52QI2", "url": "https://omabrowser.org/oma/group/Q52QI2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "M0R9G4-1", "protein_name": "Retrotransposon-like 1", "gene_name": "Rtl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIEPSEDSFETMMELKNPSSKQMESSEGSSNTVEEAPGNSGVQAEAQAGAQVEAQEGAQEEAQEGAQEGAQEGAQAEAQAEAQAEAQEEAQEEAQEGAQEEAQEGAQEGAQEGAQEEAQEGAQEEAQEGAQEEAQEEAQEEAQEEAQEGSESGLAQEKMEPPSGPLEEMQELPTDLTQEPSTRPYEEGTNDQPEDMEETSDDSNQESSDGSNHEFDNGSNHESSCGSNQESIDVSNLESSDVSNQESSYGLHQEASYSSNQEASYSSNQEASYSSNQEASYSSNQEASYSSNQEASYSSNQEASYSSNQEASYSSNQEASYSSNQETSDNSNQESSYGANQEASYSSNQESSYGANQESSDGSNQNSIDDSNRESSYGSNQEESDPLSDVSDYSMNETMTSSETQSDQDDTDLGDEEEDDDEDSEEEDPSRSSPEEVVATMGSIISLFLQMEDLEEQQRVVERIMVQALNEDRLPRLRPFSGDRRDYNEFIMLCQITMQNYPVMVNNDQLKVRFVIHHLSDVALEWANDLLEQNSHLINDFPAFLEAMSEKFEYRHTLRVAEDAMLDIRQRNRCAADYINEFLGLIPTLGWQDEVLQAHLCLGLNEDIRRYLFRIPQPDSLRSLIILVLQIEERLAERRALLRLPPESRPRSLAWMDSPAPDKWRVSSWPPNEFHPDIDRHHFFLMLLVRVNPYHSIAVKALVDTGVEGNYMDEKFAQEHYVELYEKTHRQIIQGVDGSVIGNQLVWLCTDSLACVHQKHYEWIEFDILPSTNFSIILGIKWLQTHEPEVDWCRGRCTFHSPYCLKNCSNPPPPCIALENYSMSLLPGLPHTYSDLADVFNPREADDETSDQPSSDGSDDLSESEPSELQQAGDSDQNGVFHRRRAKETLKPVSARMQEKARQQEEYWILYDMLTDRQDYIQMVPELFDQLHAASWFTKLEVLEVDKAEMKNSVAHTEDTWRASFGFSDQQMRCYRPYTMSSFSDESNNIVHVILKDILGYFVICHGREVLVYSMSKEEHPLHVRQVLLRFRYHNIYCSLDKTQFHRQKAEILGFSISPKGVKLSKKLTDIMVECPVPETRRCLQGVIELFYPYRHFVEHFSVMAEPLVKQLLSSEPYYWGEEEQEAFDSLKRAFSRAPVLYHPKPQNPFYLETGTVGSFLYASLIQTDDATGRKATCAFYSRPLSLMEVEYPQVEMRILPIRAAFMVWFRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFSVMEMPDQDDTQALFRSCWNQRGFRARFLRPLLLMAMRAGYMDSSSDSEDEDEDQDDDDEEDSEEDSEQIELNRQTMMRDLLATIPMDRILNGFLVRFTVAQIRAVVLNFFRGLIYWRTVLGVSALLVMSRARRPLSPLPEPSLEVARPQPRPTLRLILDPTLIASSGMATAIAQLLRQMPPLVGANALPARELAELVLSPRCWHRNALHSQPPRGMRFTPGFWLTLCEFFGVRVNPEEDIFPDPYQHRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDAQDNDVQEDPLGDQEAVTFRPRNLLDPEVLDFLNNRLLYTLGSDGRLTLLSRDQVARTLTRFLTMASRMALPSLAREQARLEELSDSDEELD", "length": 1635 }, "evidence": [ { "id": "Q52QI2", "url": "https://omabrowser.org/oma/group/Q52QI2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7M732-1", "protein_name": "Retrotransposon-like protein 1", "gene_name": "Rtl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEPSEDSFETMMELKNPSSKQMESSEGSSNTVEETPGSSGAQAGAQAGAQAEAQAETQVEAQAEAQAEAQVEAQVEAQAGSDSGPAQEEKEPPSGPLKEMQELPTNLLQEVEEPSSGPHQEMQELPTDLLQEVEEPSSGPHQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSDPCEASSNDLPQDMEESSDDGSNQESSDGSNHELSNGSNHESSFGSNPESSDVSNLESSGGSNQESSDGSQKESSYDSNPELSDNSNQELSDNSNQESSDSSNQSSDISNQEGSEPLSEASDYSMDETINSSETQSDQDDTDLGDDEEEEEEEGGEEEGQPKNSPEEVVATMGNVISLFLRMQDLKEQQRVAERLMMQAINEGRLPSLRPFSGDRRDYHEFVVLCQMTMQNYPSMLYNDELRVKFVIRHLTDLALEWANDLVEQNSPVINNFSAFLEAMSEKFEYRQTLRVAEDAMFNIRQGNRCAADYINEFRGLIPTLGWPDEVLQAHLCQGLNEEIRHYLFRIPQPNSLDNLIVLVLQLEEKLAERRALLRLPPESRPRSVAWMDAPAPEKWRVSSWLPNEFHPDIDRDHLFLLLLVRVDPYHSVAVRALVDSGAEGNYMDERFAQEHYVELYEKPYPQIIQGVDGIPIGNEPVWLCTEPLVCVHQKHYEYIEFDILPSPNFSIVLGMKWLRTHAPEVDWMRGRCTFHSPYCLRNCFTPPPPCIALETYSISLLPGLPHTYSDLADVFNPREADDETSDQPSSDGSDDLSESEPSELQQAGDSDQSGVFYESGARETLEPVSARMQEKARQQEKAREQEEYWILYDMLTDRQDYTQMVPELFDQLHGAAWFTKLELLGIKESEMRHTVTHTEDTWRASFGFGLHQMRCYRPFTMNSYSDEGNNIVHFILKDILGLFVICHGREVLVYSMSQEEHSQHVRQVLVRFRYHNIYCSLDKTQFHRQTAEILGFNISPKGVKLNKNLMNLIVGCPVPGSRRCLQSVIDLVYPYRHFVENFAVIAAPLVRQLLSSEPYYWGEEEQEALESLKRAFRKSPVLYHPKPQNPFYLETDITGSFLSASLVQTDDETGKKSTCAFYSRPLSTMEVEYPRVEMRILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFGVMEMPAEGDTQALFRRCWNQRGFRARFLRPLLLMSIRANLRYFDRSSETEDKEDDEEEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEEEEEDDEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEGEEEEEGEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDEEEEDEEEEDEEVPSMVRELLAAIPMDHILNGLLAHFSVAQIRAVVLNFFRGLLYWKSLLGVAAVLVMLRARQPLSPVPAPNLEVARPQHRHTLRLILDSTLIASSGMATAIAQLLSQMPPLVGANTLPARELAELFLGPRCWHRNALHSQPPRGMRFTPGFWLTLCEFFGVRVNPEDDVFPDPYQHRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDAQDNDVQEDLFGDQEAVTFRPRNLLDPEVLDFLNNRLLYTLGTDGRLTLLSRDQVAQALTRFLAMASRMALPSPAREQARLEELSDSDDELD", "length": 1744 }, "evidence": [ { "id": "Q52QI2", "url": "https://omabrowser.org/oma/group/Q52QI2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "placenta development", "id": "GO:0001890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001890", "evidence": [ { "database": "UniProtKB", "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ], "pmid": "" }, { "name": "skeletal muscle tissue development", "id": "GO:0007519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "database": "UniProtKB", "id": "Q52QI2", "url": "https://www.uniprot.org/uniprotkb/Q52QI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 776, "end_pos": 778, "annotation": "n_glycosylation_sequon" }, { "start_pos": 895, "end_pos": 897, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q52QI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1331, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q52QI2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q52QI2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 788 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 776, "end_pos": 778 }, { "start_pos": 895, "end_pos": 897 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JX3-1", "uniprot_ac": "Q56JX3", "uniprot_id": "RL31_BOVIN", "mass": { "chemical_mass": 14463.0, "monoisotopic_mass": 14463.0 }, "refseq": { "ac": "NP_001020512", "name": "large ribosomal subunit protein eL31", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020512" }, "gene_names": [ { "name": "RPL31", "type": "recommended", "evidence": [ { "id": "Q56JX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ] }, { "name": "RPL31", "type": "synonym", "evidence": [ { "id": "NP_001020512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020512" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL31", "type": "recommended", "evidence": [ { "id": "Q56JX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX3/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L31", "type": "synonym", "evidence": [ { "id": "NP_001020512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020512" }, { "id": "Q56JX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX3/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL31", "type": "synonym", "evidence": [ { "id": "NP_001020512", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020512" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3#function" }, { "database": "UniProtKB", "id": "P62899", "url": "https://www.uniprot.org/uniprotkb/P62899#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL31", "url": "https://www.uniprot.org/uniprotkb/Q56JX3", "locus": {} } ], "crossref": [ { "id": "Q56JX3", "url": "https://alphafold.ebi.ac.uk/entry/Q56JX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00463", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00463", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534279", "url": "https://www.ncbi.nlm.nih.gov/gene/534279", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534279", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534279", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q56JX3", "url": "https://www.orthodb.org/?gene=Q56JX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10956", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10956", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10956:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10956:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001020512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020512", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JX3-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN", "length": 125, "header": "sp|Q56JX3-1|RL31_BOVIN Isoform 1 of Large ribosomal subunit protein eL31 OS=Bos taurus OX=9913 GN=RPL31 PE=2 SV=1 CANONICAL=Q56JX3-1" }, "isoforms": [ { "isoform_ac": "Q56JX3-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX3/entry#Q56JX3-1", "sequence": { "sequence": "MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN", "length": 125, "header": "sp|Q56JX3-1|RL31_BOVIN Isoform 1 of Large ribosomal subunit protein eL31 OS=Bos taurus OX=9913 GN=RPL31 PE=2 SV=1 CANONICAL=Q56JX3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "site_lbl": "Ser15" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534279", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534279", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q56JX3", "url": "https://www.uniprot.org/uniprotkb/Q56JX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JX3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 15, 98 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JX5-1", "uniprot_ac": "Q56JX5", "uniprot_id": "RS25_BOVIN", "mass": { "chemical_mass": 13742.0, "monoisotopic_mass": 13742.0 }, "refseq": { "ac": "NP_001020486", "name": "small ribosomal subunit protein eS25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020486" }, "gene_names": [ { "name": "RPS25", "type": "recommended", "evidence": [ { "id": "Q56JX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX5" } ] }, { "name": "RPS25", "type": "synonym", "evidence": [ { "id": "NP_001020486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020486" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein eS25", "type": "recommended", "evidence": [ { "id": "Q56JX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX5/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S25", "type": "synonym", "evidence": [ { "id": "NP_001020486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020486" }, { "id": "Q56JX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX5/entry#names_and_taxonomy" } ] }, { "name": "small ribosomal subunit protein eS25", "type": "synonym", "evidence": [ { "id": "NP_001020486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020486" } ] } ], "function": [ { "annotation": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q56JX5", "url": "https://www.uniprot.org/uniprotkb/Q56JX5#function" }, { "database": "UniProtKB", "id": "P62851", "url": "https://www.uniprot.org/uniprotkb/P62851#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JX5", "url": "https://www.uniprot.org/uniprotkb/Q56JX5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS25", "url": "https://www.uniprot.org/uniprotkb/Q56JX5", "locus": { "chromosome": "15", "start_pos": 29588693, "end_pos": 29590407, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027772", "url": "https://www.ensembl.org/id/ENSBTAG00000027772" } ] } } ], "crossref": [ { "id": "Q56JX5", "url": "https://alphafold.ebi.ac.uk/entry/Q56JX5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018987", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018987", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282052", "url": "https://www.ncbi.nlm.nih.gov/gene/282052", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282052", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282052", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RIVHHSG", "url": "https://omabrowser.org/oma/group/RIVHHSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JX5", "url": "https://www.orthodb.org/?gene=Q56JX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JX5", "url": "https://www.uniprot.org/uniprotkb/Q56JX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JX5-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125, "header": "sp|Q56JX5-1|RS25_BOVIN Isoform 1 of Small ribosomal subunit protein eS25 OS=Bos taurus OX=9913 GN=RPS25 PE=2 SV=1 CANONICAL=Q56JX5-1" }, "isoforms": [ { "isoform_ac": "Q56JX5-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX5/entry#Q56JX5-1", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125, "header": "sp|Q56JX5-1|RS25_BOVIN Isoform 1 of Small ribosomal subunit protein eS25 OS=Bos taurus OX=9913 GN=RPS25 PE=2 SV=1 CANONICAL=Q56JX5-1" }, "locus": { "chromosome": "15", "start_pos": 29590356, "end_pos": 29588853, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040046.5", "url": "https://www.ensembl.org/id/ENSBTAT00000040046.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039829.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039829.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282052", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282052", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I1P3-1", "protein_name": "40S ribosomal protein S25", "gene_name": "Rps25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1SLJ1-1", "protein_name": "40S ribosomal protein S25", "gene_name": "RPS25", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P48588-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "RpS25", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPKKDAKSSAKQPQKTQKKKEGSGGGKAKKKKWSKGKVRDKLNNQVLFDKATYEKLYKEVPAYKLITPSVVSERLKIRGSLAKRALIELREKGLIKQVVQHHSQVIYTRATKGDEA", "length": 117 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P62851-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "RPS25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62852-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "Rps25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62853-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "Rps25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 125 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q03409-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "rps25", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPPKAAGGKSKQIQASKAAAKGSSGGAGRKKWSKGRSREKLNNAILFDKETYAKLLKEMPTAKVITTAVVSERMKCNGSLARRAIKELLSKGLIKQIIKGHGNGVYTKAQ", "length": 110 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q3E792-1", "protein_name": "Small ribosomal subunit protein eS25A", "gene_name": "RPS25A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPPKQQLSKAAKAAAALAGGKKSKKKWSKKSMKDRAQHAVILDQEKYDRILKEVPTYRYVSVSVLVDRLKIGGSLARIALRHLEKEGIIKPISKHSKQAIYTRATASE", "length": 108 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8GYL5-1", "protein_name": "Small ribosomal subunit protein eS25x", "gene_name": "RPS25D", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAPKKDKVPPPSSKPAKSGGGKQKKKKWSKGKQKEKVNNMVLFDQATYDKLLSEAPKFKLITPSILSDRLRINGSLARRAIRELMAKGTIRMVSAHSSQQIYTRATHG", "length": 108 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9T029-1", "protein_name": "Small ribosomal subunit protein eS25w", "gene_name": "RPS25E", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAPKKDKVPPPSSKPAKSGGGKQKKKKWSKGKQKEKVNNMVLFDQATYDKLLTEAPKFKLITPSILSDRMRINGSLARRAIRELMAKGVIRMVAAHSSQQIYTRATNT", "length": 108 }, "evidence": [ { "id": "Q56JX5", "url": "https://omabrowser.org/oma/group/Q56JX5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JX5", "url": "https://www.uniprot.org/uniprotkb/Q56JX5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q56JX5", "url": "https://www.uniprot.org/uniprotkb/Q56JX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JX5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JX5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JX5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JY0-1", "uniprot_ac": "Q56JY0", "uniprot_id": "HIKES_BOVIN", "mass": { "chemical_mass": 21653.0, "monoisotopic_mass": 21653.0 }, "refseq": { "ac": "NP_001029398", "name": "protein Hikeshi", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" }, "gene_names": [ { "name": "HIKESHI", "type": "recommended", "evidence": [ { "id": "Q56JY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ] }, { "name": "C11orf73", "type": "synonym", "evidence": [ { "id": "NP_001029398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" } ] }, { "name": "C29H11orf73", "type": "synonym", "evidence": [ { "id": "NP_001029398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" } ] }, { "name": "HIKESHI", "type": "synonym", "evidence": [ { "id": "NP_001029398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" } ] } ], "protein_names": [ { "name": "Protein Hikeshi", "type": "recommended", "evidence": [ { "id": "Q56JY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY0/entry#names_and_taxonomy" } ] }, { "name": "Hikeshi, heat shock protein nuclear import factor", "type": "synonym", "evidence": [ { "id": "NP_001029398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" } ] }, { "name": "protein Hikeshi", "type": "synonym", "evidence": [ { "id": "NP_001029398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398" } ] } ], "function": [ { "annotation": "Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIKESHI", "url": "https://www.uniprot.org/uniprotkb/Q56JY0", "locus": { "chromosome": "29", "start_pos": 9203376, "end_pos": 9240757, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019995", "url": "https://www.ensembl.org/id/ENSBTAG00000019995" } ] } } ], "crossref": [ { "id": "Q56JY0", "url": "https://alphafold.ebi.ac.uk/entry/Q56JY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019995", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019995", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504867", "url": "https://www.ncbi.nlm.nih.gov/gene/504867", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008493", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008493", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504867", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504867", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WWAKFER", "url": "https://omabrowser.org/oma/group/WWAKFER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JY0", "url": "https://www.orthodb.org/?gene=Q56JY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12925", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12925", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12925:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12925:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029398", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JY0-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTVPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGTMNIVRTPSVAQIGISVELLDSLAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197, "header": "sp|Q56JY0-1|HIKES_BOVIN Isoform 1 of Protein Hikeshi OS=Bos taurus OX=9913 GN=HIKESHI PE=2 SV=1 CANONICAL=Q56JY0-1" }, "isoforms": [ { "isoform_ac": "Q56JY0-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY0/entry#Q56JY0-1", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTVPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGTMNIVRTPSVAQIGISVELLDSLAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197, "header": "sp|Q56JY0-1|HIKES_BOVIN Isoform 1 of Protein Hikeshi OS=Bos taurus OX=9913 GN=HIKESHI PE=2 SV=1 CANONICAL=Q56JY0-1" }, "locus": { "chromosome": "29", "start_pos": 9240612, "end_pos": 9203672, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026632.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026632.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026632.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026632.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504867", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504867", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HXS2-1", "protein_name": "Protein Hikeshi", "gene_name": "Hikeshi", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGVPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSLAQQTPVGSAAVSSVDSFTQFTQKMLDNFYNFASSFALSQAQMTPNPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LNC7-1", "protein_name": "Protein Hikeshi", "gene_name": "HIKESHI", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVQTPSVAQIGISVELLDSLAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08202-1", "protein_name": "Protein OPI10", "gene_name": "OPI10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MFAAIASGNPLQLSVEVPNSNGLQHTIVLSRTKPKLYSHITLFILPNVTFPQDYIATVYFKLSPQEEFKLFGYLSSEKPSAIFKVQIPSSKKDAGDTSDGLGEIDMDVDDGSGAADPFTDTNGSSSNNISELIIGISIEPREQGMMKLEEWKASMNAEAQKNNSLILSRPNLGIIRNITTAGQLAQVYPSLTQELAAKIVQHAYNYLSGFLDAQGNVPIKRFDTWWDKFRNRLANDGTFLDEVTKN", "length": 246 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q53FT3-1", "protein_name": "Protein Hikeshi", "gene_name": "HIKESHI", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSMAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q568T4-1", "protein_name": "Protein Hikeshi", "gene_name": "hikeshi", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFGCLVAGRLVQTDAQQVASDKFVFNLPDYEHVNHVVVFLLGTVPFPEGLGGAVYLCVPGGAAGQVWQLLGFITNEKPSAIFRISGLKAGEGSSHPFGMMDAPAAPSMAQVGVSVEGLHLLAQQTPVSSSAVSTLDSFTQFTQKMLDSLFNFTSSFALSQSQMSPNPSEMFIPASSIRRWYENFQRRLMQNPNFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5M808-1", "protein_name": "Protein Hikeshi", "gene_name": "Hikeshi", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGVPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSLAQQTPVGSAAVSSVDSFTQFTQKMLDNFYNFASSFALSQAQMTPNPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DD02-1", "protein_name": "Protein Hikeshi", "gene_name": "Hikeshi", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGVPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSLAQQTPVGSAAVSSVDSFTQFTQKMLDNFYNFASSFALSQAQMTPNPSEMFIPANVVLKWYENFQRRLAQNPLFWKT", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W0C7-1", "protein_name": "Protein OPI10 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLFGLIVSGRLPQSDFVAVDATKLLVNVPDIESVNYLVVFLTGVSPLPVGTSAAIYFSWPDANAAPTWQYLGHINNTKPSAIFKIAQLKKSHELEAQAHGMVFGSQEISHIAQIGVSLEPELTVAQQTPAVSTANDNKQFGQRMLENFFNYASSFGVAARDIPPISSETFVPFSVVQNWYTNFQRRMEQNPNFWKY", "length": 197 }, "evidence": [ { "id": "Q56JY0", "url": "https://omabrowser.org/oma/group/Q56JY0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" }, { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" }, { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "Q56JY0", "url": "https://www.uniprot.org/uniprotkb/Q56JY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JY0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JY1-1", "uniprot_ac": "Q56JY1", "uniprot_id": "RL35A_BOVIN", "mass": { "chemical_mass": 12552.0, "monoisotopic_mass": 12552.0 }, "refseq": { "ac": "NP_001020492", "name": "large ribosomal subunit protein eL33", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020492" }, "gene_names": [ { "name": "RPL35A", "type": "recommended", "evidence": [ { "id": "Q56JY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ] }, { "name": "RPL35A", "type": "synonym", "evidence": [ { "id": "NP_001020492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020492" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL33", "type": "recommended", "evidence": [ { "id": "Q56JY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY1/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L35a", "type": "synonym", "evidence": [ { "id": "NP_001020492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020492" }, { "id": "Q56JY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY1/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL33", "type": "synonym", "evidence": [ { "id": "NP_001020492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020492" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1#function" }, { "database": "UniProtKB", "id": "P18077", "url": "https://www.uniprot.org/uniprotkb/P18077#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL35A", "url": "https://www.uniprot.org/uniprotkb/Q56JY1", "locus": { "chromosome": "1", "start_pos": 70176689, "end_pos": 70179468, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014208", "url": "https://www.ensembl.org/id/ENSBTAG00000014208" } ] } } ], "crossref": [ { "id": "Q56JY1", "url": "https://alphafold.ebi.ac.uk/entry/Q56JY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014208", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014208", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506768", "url": "https://www.ncbi.nlm.nih.gov/gene/506768", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506768", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506768", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YRTNKHH", "url": "https://omabrowser.org/oma/group/YRTNKHH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JY1", "url": "https://www.orthodb.org/?gene=Q56JY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01247", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01247", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020492", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JY1-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKITRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110, "header": "sp|Q56JY1-1|RL35A_BOVIN Isoform 1 of Large ribosomal subunit protein eL33 OS=Bos taurus OX=9913 GN=RPL35A PE=3 SV=1 CANONICAL=Q56JY1-1" }, "isoforms": [ { "isoform_ac": "Q56JY1-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1/entry#Q56JY1-1", "sequence": { "sequence": "MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKITRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110, "header": "sp|Q56JY1-1|RL35A_BOVIN Isoform 1 of Large ribosomal subunit protein eL33 OS=Bos taurus OX=9913 GN=RPL35A PE=3 SV=1 CANONICAL=Q56JY1-1" }, "locus": { "chromosome": "1", "start_pos": 70179434, "end_pos": 70176742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018888.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018888.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018888.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018888.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 59, "start_aa": "Thr", "end_pos": 59, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr59", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506768", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506768", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TPT1-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "RPL35A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8L2QJQ6-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "Rpl35al11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRLWCKAIFAGYKPGLLNQREYTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGVVRAKFQSNLPAKAIGHRIRVMLYPSQI", "length": 110 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O55142-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "Rpl35a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04646-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "Rpl35a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P05744-1", "protein_name": "Large ribosomal subunit protein eL33A", "gene_name": "RPL33A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQDAQFYLGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIFLYPSNI", "length": 107 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P18077-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "RPL35A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI", "length": 110 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q55BN7-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "rpl35a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKIYSKGVVLGYRRSQATQYPNISLIKIEGVVSREDSTFYLGKKVCLVSKVSKSAKNPTGHKISWGKICKTHGSSGVVQARFARNLPPKAMGAPVRVMLYPSNI", "length": 105 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C912-1", "protein_name": "Large ribosomal subunit protein eL33y", "gene_name": "RPL35AC", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVKGRQGERVRLYVRGTILGYKRSKSNQYPNTSLVQIEGVNTQEEVNWYKGKRMAYIYKAKTKKNGSHYRCIWGKVTRPHGNSGVVRAKFTSNLPPKSMGSRVRVFMYPSNI", "length": 112 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VNB9-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "RpL35A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADTQAKSTTAPKAAKAQKAPKAVKAPKAEKPAASEAKVSAKKYKRHGRLFAKAVFTGYKRGLRNQHENQAILKIEGARRKEHGSFYVGKRCVYVYKAETKKCVPQHPERKTRVRAVWGKVTRIHGNTGAVRARFNRNLPGHAMGHRIRIMLYPSRI", "length": 157 }, "evidence": [ { "id": "Q56JY1", "url": "https://omabrowser.org/oma/group/Q56JY1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q56JY1", "url": "https://www.uniprot.org/uniprotkb/Q56JY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JY1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 110, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JY1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JY1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 59 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 55, "end_pos": 57 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JY4-1", "uniprot_ac": "Q56JY4", "uniprot_id": "TOM6_BOVIN", "mass": { "chemical_mass": 7874.0, "monoisotopic_mass": 7874.0 }, "refseq": { "ac": "NP_001107190", "name": "mitochondrial import receptor subunit TOM6 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" }, "gene_names": [ { "name": "TOMM6", "type": "recommended", "evidence": [ { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ] }, { "name": "OBTP", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" }, { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ] }, { "name": "TOM6", "type": "synonym", "evidence": [ { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ] }, { "name": "TOMM6", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] } ], "protein_names": [ { "name": "Mitochondrial import receptor subunit TOM6 homolog", "type": "recommended", "evidence": [ { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4/entry#names_and_taxonomy" } ] }, { "name": "C6orf49-like protein", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] }, { "name": "Overexpressed breast tumor protein homolog", "type": "synonym", "evidence": [ { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4/entry#names_and_taxonomy" } ] }, { "name": "Translocase of outer membrane 6 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "Q56JY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY4/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import receptor subunit TOM6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] }, { "name": "overexpressed breast tumor protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] }, { "name": "translocase of outer membrane 6 kDa subunit homolog", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] }, { "name": "translocase of outer mitochondrial membrane 6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001107190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190" } ] } ], "function": [ { "annotation": "Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4#function" }, { "database": "UniProtKB", "id": "Q96B49", "url": "https://www.uniprot.org/uniprotkb/Q96B49#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM6", "url": "https://www.uniprot.org/uniprotkb/Q56JY4", "locus": { "chromosome": "23", "start_pos": 15601893, "end_pos": 15600547, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008977", "url": "https://www.ensembl.org/id/ENSBTAG00000008977" } ] } } ], "crossref": [ { "id": "Q56JY4", "url": "https://alphafold.ebi.ac.uk/entry/Q56JY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008977", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008977", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505031", "url": "https://www.ncbi.nlm.nih.gov/gene/505031", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505031", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505031", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WIRGAYR", "url": "https://omabrowser.org/oma/group/WIRGAYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JY4", "url": "https://www.orthodb.org/?gene=Q56JY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15527", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15527", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15527:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15527:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5205685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001107190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107190", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JY4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSGAGVTAAGSANEAPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV", "length": 74, "header": "sp|Q56JY4-1|TOM6_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM6 homolog OS=Bos taurus OX=9913 GN=TOMM6 PE=3 SV=1 CANONICAL=Q56JY4-1" }, "isoforms": [ { "isoform_ac": "Q56JY4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY4/entry#Q56JY4-1", "sequence": { "sequence": "MASSGAGVTAAGSANEAPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV", "length": 74, "header": "sp|Q56JY4-1|TOM6_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM6 homolog OS=Bos taurus OX=9913 GN=TOMM6 PE=3 SV=1 CANONICAL=Q56JY4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505031", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505031", "resource": "KEGG Pathway" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IPA8-1", "protein_name": "Mitochondrial import receptor subunit TOM6 homolog", "gene_name": "Tomm6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSGVTVSASGAASEAPEVPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV", "length": 74 }, "evidence": [ { "id": "Q56JY4", "url": "https://omabrowser.org/oma/group/Q56JY4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96B49-1", "protein_name": "Mitochondrial import receptor subunit TOM6 homolog", "gene_name": "TOMM6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSTVPVSAAGSANETPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV", "length": 74 }, "evidence": [ { "id": "Q56JY4", "url": "https://omabrowser.org/oma/group/Q56JY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQN3-1", "protein_name": "Mitochondrial import receptor subunit TOM6 homolog", "gene_name": "Tomm6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSGVTVSAAGSASEASEVPDNVGDWLRGVFRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV", "length": 74 }, "evidence": [ { "id": "Q56JY4", "url": "https://omabrowser.org/oma/group/Q56JY4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "X1WBS5-1", "protein_name": "Mitochondrial import receptor subunit TOM6 homolog", "gene_name": "tomm6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGKKSEGKSGGVTGWISSACRFAADRNDFRRNLLVNLGLFAAGVWVARNLSDFDLMSPQPVT", "length": 63 }, "evidence": [ { "id": "Q56JY4", "url": "https://omabrowser.org/oma/group/Q56JY4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ], "pmid": "" }, { "name": "mitochondrial outer membrane translocase complex", "id": "GO:0005742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005742", "evidence": [ { "database": "UniProtKB", "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q56JY4", "url": "https://www.uniprot.org/uniprotkb/Q56JY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JY4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 74, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JY4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JY4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JY9-1", "uniprot_ac": "Q56JY9", "uniprot_id": "B9D2_BOVIN", "mass": { "chemical_mass": 19358.0, "monoisotopic_mass": 19358.0 }, "refseq": { "ac": "NP_001035683", "name": "B9 domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035683" }, "gene_names": [ { "name": "B9D2", "type": "recommended", "evidence": [ { "id": "Q56JY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ] }, { "name": "B9D2", "type": "synonym", "evidence": [ { "id": "NP_001035683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035683" } ] } ], "protein_names": [ { "name": "B9 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q56JY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY9/entry#names_and_taxonomy" } ] }, { "name": "B9 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001035683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035683" } ] }, { "name": "B9 protein domain 2", "type": "synonym", "evidence": [ { "id": "NP_001035683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035683" } ] } ], "function": [ { "annotation": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B9D2", "url": "https://www.uniprot.org/uniprotkb/Q56JY9", "locus": { "chromosome": "18", "start_pos": 50509252, "end_pos": 50517800, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023452", "url": "https://www.ensembl.org/id/ENSBTAG00000023452" } ] } } ], "crossref": [ { "id": "Q56JY9", "url": "https://alphafold.ebi.ac.uk/entry/Q56JY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "616609", "url": "https://www.ncbi.nlm.nih.gov/gene/616609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q56JY9", "url": "https://www.orthodb.org/?gene=Q56JY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12968:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12968:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035683", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JY9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEVHVIGQIMGATGFSESSLFCKWGVHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHGDAIYSGADRYRLHTTSGGTVHLELSLLLRHFDRYGVEC", "length": 175, "header": "sp|Q56JY9-1|B9D2_BOVIN Isoform 1 of B9 domain-containing protein 2 OS=Bos taurus OX=9913 GN=B9D2 PE=2 SV=1 CANONICAL=Q56JY9-1" }, "isoforms": [ { "isoform_ac": "Q56JY9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JY9/entry#Q56JY9-1", "sequence": { "sequence": "MAEVHVIGQIMGATGFSESSLFCKWGVHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHGDAIYSGADRYRLHTTSGGTVHLELSLLLRHFDRYGVEC", "length": 175, "header": "sp|Q56JY9-1|B9D2_BOVIN Isoform 1 of B9 domain-containing protein 2 OS=Bos taurus OX=9913 GN=B9D2 PE=2 SV=1 CANONICAL=Q56JY9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616609", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" }, { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "Q56JY9", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 175, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JY9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JY9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q56JY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JY9" }, { "id": "PRU00713", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00713" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 B9-type", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 118, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JZ1-1", "uniprot_ac": "Q56JZ1", "uniprot_id": "RL13_BOVIN", "mass": { "chemical_mass": 24292.0, "monoisotopic_mass": 24292.0 }, "refseq": { "ac": "NP_001015543", "name": "large ribosomal subunit protein eL13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015543" }, "gene_names": [ { "name": "RPL13", "type": "recommended", "evidence": [ { "id": "Q56JZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ] }, { "name": "RPL13", "type": "synonym", "evidence": [ { "id": "NP_001015543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015543" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL13", "type": "recommended", "evidence": [ { "id": "Q56JZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L13", "type": "synonym", "evidence": [ { "id": "NP_001015543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015543" }, { "id": "Q56JZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL13", "type": "synonym", "evidence": [ { "id": "NP_001015543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015543" } ] } ], "function": [ { "annotation": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1#function" }, { "database": "UniProtKB", "id": "P26373", "url": "https://www.uniprot.org/uniprotkb/P26373#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL13", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1", "locus": { "chromosome": "18", "start_pos": 14492658, "end_pos": 14490263, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012044", "url": "https://www.ensembl.org/id/ENSBTAG00000012044" } ] } } ], "crossref": [ { "id": "Q56JZ1", "url": "https://alphafold.ebi.ac.uk/entry/Q56JZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "508221", "url": "https://www.ncbi.nlm.nih.gov/gene/508221", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508221", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508221", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q56JZ1", "url": "https://www.orthodb.org/?gene=Q56JZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11722:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11722:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSRNGMILKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPLRPVVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKCTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK", "length": 211, "header": "sp|Q56JZ1-1|RL13_BOVIN Isoform 1 of Large ribosomal subunit protein eL13 OS=Bos taurus OX=9913 GN=RPL13 PE=2 SV=3 CANONICAL=Q56JZ1-1" }, "isoforms": [ { "isoform_ac": "Q56JZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1/entry#Q56JZ1-1", "sequence": { "sequence": "MAPSRNGMILKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPLRPVVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKCTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK", "length": 211, "header": "sp|Q56JZ1-1|RL13_BOVIN Isoform 1 of Large ribosomal subunit protein eL13 OS=Bos taurus OX=9913 GN=RPL13 PE=2 SV=3 CANONICAL=Q56JZ1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "site_lbl": "Ser52" }, { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "site_lbl": "Ser77" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508221", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508221", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JZ1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 52, 77 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56K04-1", "uniprot_ac": "Q56K04", "uniprot_id": "CRIP1_BOVIN", "mass": { "chemical_mass": 8506.0, "monoisotopic_mass": 8506.0 }, "refseq": { "ac": "NP_001020520", "name": "cysteine-rich protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520" }, "gene_names": [ { "name": "CRIP1", "type": "recommended", "evidence": [ { "id": "Q56K04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ] }, { "name": "CRIP1", "type": "synonym", "evidence": [ { "id": "NP_001020520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520" } ] } ], "protein_names": [ { "name": "Cysteine-rich protein 1", "type": "recommended", "evidence": [ { "id": "Q56K04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K04/entry#names_and_taxonomy" } ] }, { "name": "CRP-1", "type": "synonym", "evidence": [ { "id": "NP_001020520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520" }, { "id": "Q56K04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K04/entry#names_and_taxonomy" } ] }, { "name": "cysteine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001020520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520" } ] }, { "name": "intestinal cysteine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001020520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520" } ] } ], "function": [ { "annotation": "Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04#function" }, { "database": "UniProtKB", "id": "A0A3Q1MWF7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWF7#function" }, { "database": "UniProtKB", "id": "ARBA00055254", "url": "https://www.uniprot.org/uniprotkb/ARBA00055254#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRIP1", "url": "https://www.uniprot.org/uniprotkb/Q56K04", "locus": {} } ], "crossref": [ { "id": "Q56K04", "url": "https://alphafold.ebi.ac.uk/entry/Q56K04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047229", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09478", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09478", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "574093", "url": "https://www.ncbi.nlm.nih.gov/gene/574093", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:574093", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:574093", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q56K04", "url": "https://www.orthodb.org/?gene=Q56K04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001020520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020520", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWF7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56K04-1", "url": "https://www.uniprot.org/uniprotkb/Q56K04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKCPKCSKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK", "length": 77, "header": "sp|Q56K04-1|CRIP1_BOVIN Isoform 1 of Cysteine-rich protein 1 OS=Bos taurus OX=9913 GN=CRIP1 PE=3 SV=3 CANONICAL=Q56K04-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MWF7-1", "url": "https://www.uniprot.org/uniprotkb/Q56K04/entry#A0A3Q1MWF7-1", "sequence": { "sequence": "VPPALYLGKGLERYDTLICISLHYSGYLRGSSTLRRGWGGARGVLSPALGSLRPESGARAGLLRGSSPVQSARVPADLLDPLGPHSAVGQARVLPQGESGPDDLSWPVGWNPRPPGPSPGLRGAGRWGRVPKGRSPGVLERRGPGATHPVQRSGLLPPGHLPRSGATMPKCPKCSKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK", "length": 244, "header": "tr|A0A3Q1MWF7-1|A0A3Q1MWF7_BOVIN Computationally mapped isoform of Cysteine-rich protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=Q56K04-1" }, "locus": {} }, { "isoform_ac": "Q56K04-1", "url": "https://www.uniprot.org/uniprotkb/Q56K04/entry#Q56K04-1", "sequence": { "sequence": "MPKCPKCSKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK", "length": 77, "header": "sp|Q56K04-1|CRIP1_BOVIN Isoform 1 of Cysteine-rich protein 1 OS=Bos taurus OX=9913 GN=CRIP1 PE=3 SV=3 CANONICAL=Q56K04-1" }, "locus": { "chromosome": "21", "start_pos": 69756951, "end_pos": 69755724, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063903.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063903.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054703.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054703.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:574093", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:574093", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cellular response to UV-B", "id": "GO:0071493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071493", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "prostate gland stromal morphogenesis", "id": "GO:0060741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060741", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "response to zinc ion", "id": "GO:0010043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010043", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "cellular response to antibiotic", "id": "GO:0071236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071236", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "Q56K04", "url": "https://www.uniprot.org/uniprotkb/Q56K04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56K04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 77, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56K04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56K04" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q56K04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K04" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 63, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56K12-1", "uniprot_ac": "Q56K12", "uniprot_id": "OAZ1_BOVIN", "mass": { "chemical_mass": 25448.0, "monoisotopic_mass": 25448.0 }, "refseq": {}, "gene_names": [ { "name": "OAZ1", "type": "recommended", "evidence": [ { "id": "Q56K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ] } ], "protein_names": [ { "name": "Ornithine decarboxylase antizyme 1", "type": "recommended", "evidence": [ { "id": "Q56K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K12/entry#names_and_taxonomy" } ] }, { "name": "ODC-Az", "type": "synonym", "evidence": [ { "id": "Q56K12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56K12/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12#function" }, { "database": "UniProtKB", "id": "P54368", "url": "https://www.uniprot.org/uniprotkb/P54368#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OAZ1", "url": "https://www.uniprot.org/uniprotkb/Q56K12", "locus": { "chromosome": "7", "start_pos": 21282789, "end_pos": 21286350, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018522", "url": "https://www.ensembl.org/id/ENSBTAG00000018522" } ] } } ], "crossref": [ { "id": "Q56K12", "url": "https://alphafold.ebi.ac.uk/entry/Q56K12", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038581", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038581", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10279", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10279:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56K12-1", "url": "https://www.uniprot.org/uniprotkb/Q56K12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKSSLQRILNSHCFAREKEGDKPSATVHATRTMPLLSLHSRGGRSSESSRVSINCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNVTEELTSNNKTRIFNVQSRLTEAKHINWRAVLSNSCLYVEIPGGALPEGSKDSFAVLLEFAEEQLHVDHVFICFHKNRDDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEE", "length": 227, "header": "sp|Q56K12-1|OAZ1_BOVIN Isoform 1 of Ornithine decarboxylase antizyme 1 OS=Bos taurus OX=9913 GN=OAZ1 PE=2 SV=3 CANONICAL=Q56K12-1" }, "isoforms": [ { "isoform_ac": "Q56K12-1", "url": "https://www.uniprot.org/uniprotkb/Q56K12/entry#Q56K12-1", "sequence": { "sequence": "MVKSSLQRILNSHCFAREKEGDKPSATVHATRTMPLLSLHSRGGRSSESSRVSINCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNVTEELTSNNKTRIFNVQSRLTEAKHINWRAVLSNSCLYVEIPGGALPEGSKDSFAVLLEFAEEQLHVDHVFICFHKNRDDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEE", "length": 227, "header": "sp|Q56K12-1|OAZ1_BOVIN Isoform 1 of Ornithine decarboxylase antizyme 1 OS=Bos taurus OX=9913 GN=OAZ1 PE=2 SV=3 CANONICAL=Q56K12-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of intracellular protein transport", "id": "GO:0090316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" }, { "name": "polyamine biosynthetic process", "id": "GO:0006596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006596", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" }, { "name": "viral translational frameshifting", "id": "GO:0075523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075523", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ornithine decarboxylase inhibitor activity", "id": "GO:0008073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008073", "evidence": [ { "database": "UniProtKB", "id": "Q56K12", "url": "https://www.uniprot.org/uniprotkb/Q56K12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56K12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 227, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56K12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56K12" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 111, "end_pos": 113 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CQ0-1", "uniprot_ac": "Q58CQ0", "uniprot_id": "CSTOS_BOVIN", "mass": { "chemical_mass": 27813.0, "monoisotopic_mass": 27813.0 }, "refseq": { "ac": "NP_001026923", "name": "protein CUSTOS", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" }, "gene_names": [ { "name": "CUSTOS", "type": "recommended", "evidence": [ { "id": "Q58CQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ] }, { "name": "C12orf43", "type": "synonym", "evidence": [ { "id": "NP_001026923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" } ] }, { "name": "C17H12orf43", "type": "synonym", "evidence": [ { "id": "NP_001026923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" } ] }, { "name": "CUSTOS", "type": "synonym", "evidence": [ { "id": "NP_001026923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" } ] } ], "protein_names": [ { "name": "Protein CUSTOS", "type": "recommended", "evidence": [ { "id": "Q58CQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0/entry#names_and_taxonomy" } ] }, { "name": "protein CUSTOS", "type": "synonym", "evidence": [ { "id": "NP_001026923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" } ] }, { "name": "uncharacterized protein C12orf43 homolog", "type": "synonym", "evidence": [ { "id": "NP_001026923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923" } ] } ], "function": [ { "annotation": "Plays a role in the regulation of Wnt signaling pathway during early development.", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0#function" }, { "database": "UniProtKB", "id": "A9C3N6", "url": "https://www.uniprot.org/uniprotkb/A9C3N6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUSTOS", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0", "locus": {} } ], "crossref": [ { "id": "Q58CQ0", "url": "https://alphafold.ebi.ac.uk/entry/Q58CQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "507351", "url": "https://www.ncbi.nlm.nih.gov/gene/507351", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507351", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507351", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CQ0", "url": "https://www.orthodb.org/?gene=Q58CQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14482", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14482", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14482:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14482:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23999", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23999", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026923", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CQ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDLESSSSSSSDEEELERCREAALPAWGLEQRPRGPEKPGVDATNAKLPANQPSLMHKVDEHEQDGNELQTTPEFRAHVAKKLGALLDSSITISEIVKEPRKSEVQQGALEDDGFRLFFTSIPGGPEKEAAPQPCRKRLPSSSSSDDGDEELRRCREAAVSASDILQESAIHGHVSVEKKKKRKLKKKAKKEDSADVAATATSKAEVGRQEKESAQLNGDQAPPGTKKKKRKKKTKKASEASLSPPTKSAAAVPSN", "length": 257, "header": "sp|Q58CQ0-1|CSTOS_BOVIN Isoform 1 of Protein CUSTOS OS=Bos taurus OX=9913 GN=CUSTOS PE=2 SV=1 CANONICAL=Q58CQ0-1" }, "isoforms": [ { "isoform_ac": "Q58CQ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0/entry#Q58CQ0-1", "sequence": { "sequence": "MSDLESSSSSSSDEEELERCREAALPAWGLEQRPRGPEKPGVDATNAKLPANQPSLMHKVDEHEQDGNELQTTPEFRAHVAKKLGALLDSSITISEIVKEPRKSEVQQGALEDDGFRLFFTSIPGGPEKEAAPQPCRKRLPSSSSSDDGDEELRRCREAAVSASDILQESAIHGHVSVEKKKKRKLKKKAKKEDSADVAATATSKAEVGRQEKESAQLNGDQAPPGTKKKKRKKKTKKASEASLSPPTKSAAAVPSN", "length": 257, "header": "sp|Q58CQ0-1|CSTOS_BOVIN Isoform 1 of Protein CUSTOS OS=Bos taurus OX=9913 GN=CUSTOS PE=2 SV=1 CANONICAL=Q58CQ0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "site_lbl": "Ser55" }, { "start_pos": 73, "end_pos": 73, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "site_lbl": "Thr73" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507351", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507351", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "pmid": "" }, { "name": "Spemann organizer formation", "id": "GO:0060061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060061", "evidence": [ { "database": "UniProtKB", "id": "Q58CQ0", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CQ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 257, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CQ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CQ0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CQ0" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nucleolar localization signal (NLS)", "eco_id": "ECO_0000250", "start_pos": 228, "end_pos": 236, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 55, 73 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CU5-1", "uniprot_ac": "Q58CU5", "uniprot_id": "TM213_BOVIN", "mass": { "chemical_mass": 11885.0, "monoisotopic_mass": 11885.0 }, "refseq": { "ac": "NP_001035603", "name": "transmembrane protein 213", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035603" }, "gene_names": [ { "name": "TMEM213", "type": "recommended", "evidence": [ { "id": "Q58CU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU5" } ] }, { "name": "TMEM213", "type": "synonym", "evidence": [ { "id": "NP_001035603", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035603" } ] } ], "protein_names": [ { "name": "Transmembrane protein 213", "type": "recommended", "evidence": [ { "id": "Q58CU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU5/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 213", "type": "synonym", "evidence": [ { "id": "NP_001035603", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035603" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CU5", "url": "https://www.uniprot.org/uniprotkb/Q58CU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM213", "url": "https://www.uniprot.org/uniprotkb/Q58CU5", "locus": { "chromosome": "4", "start_pos": 102467306, "end_pos": 102461045, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001527", "url": "https://www.ensembl.org/id/ENSBTAG00000001527" } ] } } ], "crossref": [ { "id": "Q58CU5", "url": "https://alphafold.ebi.ac.uk/entry/Q58CU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "510137", "url": "https://www.ncbi.nlm.nih.gov/gene/510137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510137", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510137", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CU5", "url": "https://www.orthodb.org/?gene=Q58CU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36293", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36293", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36293:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36293:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035603", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CU5", "url": "https://www.uniprot.org/uniprotkb/Q58CU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CU5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRLHLAPWTSLVLGLAFLSFHPVYLAEASSGSNSTSTVHHPENLETLEQCPNVDFCPQAARCCHTGVDEYGWIAAAVGWSLLFLTLILLCVDKLMKLTPDESKDLQA", "length": 108, "header": "sp|Q58CU5-1|TM213_BOVIN Isoform 1 of Transmembrane protein 213 OS=Bos taurus OX=9913 GN=TMEM213 PE=3 SV=2 CANONICAL=Q58CU5-1" }, "isoforms": [ { "isoform_ac": "Q58CU5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU5/entry#Q58CU5-1", "sequence": { "sequence": "MKRLHLAPWTSLVLGLAFLSFHPVYLAEASSGSNSTSTVHHPENLETLEQCPNVDFCPQAARCCHTGVDEYGWIAAAVGWSLLFLTLILLCVDKLMKLTPDESKDLQA", "length": 108, "header": "sp|Q58CU5-1|TM213_BOVIN Isoform 1 of Transmembrane protein 213 OS=Bos taurus OX=9913 GN=TMEM213 PE=3 SV=2 CANONICAL=Q58CU5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CU5", "url": "https://www.uniprot.org/uniprotkb/Q58CU5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510137", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510137", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58CU5", "url": "https://www.uniprot.org/uniprotkb/Q58CU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 108, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CU5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CU6-1", "uniprot_ac": "Q58CU6", "uniprot_id": "CA198_BOVIN", "mass": { "chemical_mass": 35529.0, "monoisotopic_mass": 35529.0 }, "refseq": { "ac": "NP_001035682", "name": "uncharacterized protein C1orf198 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035682" }, "gene_names": [ { "name": "C1orf198", "type": "synonym", "evidence": [ { "id": "NP_001035682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035682" } ] }, { "name": "C28H1orf198", "type": "synonym", "evidence": [ { "id": "NP_001035682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035682" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C1orf198 homolog", "type": "recommended", "evidence": [ { "id": "Q58CU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU6/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C1orf198 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035682" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/Q58CU6", "locus": {} } ], "crossref": [ { "id": "Q58CU6", "url": "https://alphafold.ebi.ac.uk/entry/Q58CU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616380", "url": "https://www.ncbi.nlm.nih.gov/gene/616380", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616380", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616380", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EQSEFHS", "url": "https://omabrowser.org/oma/group/EQSEFHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58CU6", "url": "https://www.orthodb.org/?gene=Q58CU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34394:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34394:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CU6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASMAAAIAASRTAVMSANRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPSASAPGDPEELARFPGLRGPTGQKVVRFGDEDITWQDEHSAPFSWETRSQMEFSISSLSIQEPSCSTAGEPRPPSKAPQGSQALRAPQGGKSSSLDALGPAWKEEEASFWKINAERSRGEGPEAEFQSLTPSQIKSMEKGEKVLPGCYRQEPAPRAREAKAEKPSPLRQEQRAAPSVSTECERPQPAQACASPPSEAGPSGPMGKPVSPEVMEAVEDMEDALFLEPVPVQVSSSNVILKTGFDFLDNW", "length": 325, "header": "sp|Q58CU6-1|CA198_BOVIN Isoform 1 of Uncharacterized protein C1orf198 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q58CU6-1" }, "isoforms": [ { "isoform_ac": "Q58CU6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU6/entry#Q58CU6-1", "sequence": { "sequence": "MASMAAAIAASRTAVMSANRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPSASAPGDPEELARFPGLRGPTGQKVVRFGDEDITWQDEHSAPFSWETRSQMEFSISSLSIQEPSCSTAGEPRPPSKAPQGSQALRAPQGGKSSSLDALGPAWKEEEASFWKINAERSRGEGPEAEFQSLTPSQIKSMEKGEKVLPGCYRQEPAPRAREAKAEKPSPLRQEQRAAPSVSTECERPQPAQACASPPSEAGPSGPMGKPVSPEVMEAVEDMEDALFLEPVPVQVSSSNVILKTGFDFLDNW", "length": 325, "header": "sp|Q58CU6-1|CA198_BOVIN Isoform 1 of Uncharacterized protein C1orf198 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q58CU6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "site_lbl": "Ser126" }, { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "site_lbl": "Ser171" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "site_lbl": "Ser285" }, { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "site_lbl": "Ser37" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616380", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616380", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZY47-1", "protein_name": "Similar to human chromosome 1 open reading frame 198", "gene_name": "C19h1orf198", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASMAAAIAASRSAVMSGNRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPRAPAAAADAGDVQDPERFPGLRGPTGQKLVRFGDEDITWQDEHSAPFSWETRSQMEFSISSLSVQEPSTATMTNDTRPLAKASQGTQGSKPAQSSRSSSLDALGPARKEEEASFWKINAERSREGHEAEFQSLTPSQIKSMEKGEKVLPACYRQEPAIKDREAKPVPQEPQILPSVSTEQEAPQPVQAPASLLPKSTPTKSPEKPPPSAAQQDEDDDDDDPLFSEPALSQISSSVLLKTGFDFLDNW", "length": 324 }, "evidence": [ { "id": "Q58CU6", "url": "https://omabrowser.org/oma/group/Q58CU6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4KMC9-1", "protein_name": "Uncharacterized protein C1orf198 homolog", "gene_name": "", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAAAMAGAADPPHLTEAKKLEYFSSINSMARKIMQEREKIKETYGSAWSQMSPVEQDTAIDNGMMDPRIRARYAMHRVDRDEVICYPKLLIQTGQKIVHFGEEDLTWQDEHSAPFSWETKSQMDFSISNMTELFVPPSVNEPKPKTSQTTKPPSNDESSFWKISAERSRLDNEKAEFPSLTPSQIKSLEKGEKPLPSYLRLESGSRDMEEVPVSRPAKQRAPKPPAPPPPPPVPISMTPAAISVTPTPPAPVPSLEEGWERAQSTLPSVSSTTDEVFSPGLVTRSSSQSNSTVKDVEKAEASPASSPTFSQFNTSSSILKTGFDFLDNW", "length": 330 }, "evidence": [ { "id": "Q58CU6", "url": "https://omabrowser.org/oma/group/Q58CU6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8C3W1-1", "protein_name": "Uncharacterized protein C1orf198 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASMAAAIAASRSAVMSGNRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPRAPAAAADAGDVRDPARFPGLRGPTGQKLVRFGDEDITWQDEHSAPFSWETRSQMEFSISSLSIQEPSAATVTSDARSLAKAPQGTQGSKPAQSSRSSSLDALGPARKEEEAPFWKINAERSREGPEAEFQSLTPSQIKSMEKGEKVLPACYRQEPTTKDREAKPVPQEQQTLPSVSAEQEVPQPVQAPASLLPKATPTESPEKPPPPAVQRDEDDDALFSEPALAQISSSNVLLKTGFDFLDNW", "length": 322 }, "evidence": [ { "id": "Q58CU6", "url": "https://omabrowser.org/oma/group/Q58CU6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H425-1", "protein_name": "Uncharacterized protein C1orf198", "gene_name": "C1orf198", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASMAAAIAASRSAVMSGNRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPRAPAPRDPGDSEELTRFPGLRGPTGQKVVRFGDEDLTWQDEHSAPFSWETKSQMEFSISALSIQEPSNGTAASEPRPLSKASQGSQALKSSQGSRSSSLDALGPTRKEEEASFWKINAERSRGEGPEAEFQSLTPSQIKSMEKGEKVLPPCYRQEPAPKDREAKVERPSTLRQEQRPLPNVSTERERPQPVQAFSSALHEAAPSQLEGKLPSPDVRQDDGEDTLFSEPKFAQVSSSNVVLKTGFDFLDNW", "length": 327 }, "evidence": [ { "id": "Q58CU6", "url": "https://omabrowser.org/oma/group/Q58CU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CU6", "url": "https://www.uniprot.org/uniprotkb/Q58CU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CU6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 325, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CU6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CU6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 37, 126, 171, 285 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CW6-1", "uniprot_ac": "Q58CW6", "uniprot_id": "CARTF_BOVIN", "mass": { "chemical_mass": 78135.0, "monoisotopic_mass": 78135.0 }, "refseq": { "ac": "NP_001027465", "name": "calcium-responsive transcription factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" }, "gene_names": [ { "name": "CARF", "type": "recommended", "evidence": [ { "id": "Q58CW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ] }, { "name": "ALS2CR8", "type": "synonym", "evidence": [ { "id": "NP_001027465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" }, { "id": "Q58CW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ] }, { "name": "CARF", "type": "synonym", "evidence": [ { "id": "NP_001027465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" } ] } ], "protein_names": [ { "name": "Calcium-responsive transcription factor", "type": "recommended", "evidence": [ { "id": "Q58CW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW6/entry#names_and_taxonomy" } ] }, { "name": "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein", "type": "synonym", "evidence": [ { "id": "Q58CW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CW6/entry#names_and_taxonomy" } ] }, { "name": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8", "type": "synonym", "evidence": [ { "id": "NP_001027465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" } ] }, { "name": "amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001027465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" } ] }, { "name": "calcium-responsive transcription factor", "type": "synonym", "evidence": [ { "id": "NP_001027465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465" } ] } ], "function": [ { "annotation": "Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CARF", "url": "https://www.uniprot.org/uniprotkb/Q58CW6", "locus": { "chromosome": "2", "start_pos": 91310808, "end_pos": 91242784, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016000", "url": "https://www.ensembl.org/id/ENSBTAG00000016000" } ] } } ], "crossref": [ { "id": "Q58CW6", "url": "https://alphafold.ebi.ac.uk/entry/Q58CW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "509072", "url": "https://www.ncbi.nlm.nih.gov/gene/509072", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509072", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509072", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CW6", "url": "https://www.orthodb.org/?gene=Q58CW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14694", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14694", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14694:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14694:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15299", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15299", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001027465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027465", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CW6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQSVDSLKVNHNDSEESKTDSQHLTYMDSSEPSFGQDGSPRVLPVTTPEEDGSLTSQNIPGPLTQAQILSAEQFHLVDQNGQPVQYELQSLGDSNAQMMIVASPSENGQVLRVIPSPQTGMTQVIIPQGPLVDENSPQDVSEEKPSDRNLPAVRVDALADSNSSYVLHPQASLTLPKKTVTRILEEPLLAPLQPLSSNTPIWACRLRSCEKIGDSYRGYCVSETELESVLTFHKQQTQSVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKGFQLKKIGELENRSCQLYKATCPARIYIKKVQKFPDYRVPTDPKIDRKIIRMEQEKAFNLLKKNLVDAGGVLRWYVQLPTQQAHQYHELETPCLPLSSSSFPISSLEEEEAAIRDENCTLPSRLHPQVAHKIQELVSQGIEQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIRNHIHEVQKSLRNGDNICNSEIIPATLQWTTDSGNILRETVTVTLAEGNSQGESVSSKLETNQTRNSLSPEPAQLLSSLSSFQPKIFTHLQGLQLQPRFTSDGSPALISVNNHPSSSPSRLLDSVRSVVMNNNSLLLGQTHCLQTDTPLTPNSSISSTMSNLPGPDQNLVAVDQLVEVEDVEDTETLEGNVHRILLGNVQTIPIQIIDNPPVLSNFGSILKEPIFDCFGGPIKI", "length": 703, "header": "sp|Q58CW6-1|CARTF_BOVIN Isoform 1 of Calcium-responsive transcription factor OS=Bos taurus OX=9913 GN=CARF PE=2 SV=1 CANONICAL=Q58CW6-1" }, "isoforms": [ { "isoform_ac": "Q58CW6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CW6/entry#Q58CW6-1", "sequence": { "sequence": "MEQSVDSLKVNHNDSEESKTDSQHLTYMDSSEPSFGQDGSPRVLPVTTPEEDGSLTSQNIPGPLTQAQILSAEQFHLVDQNGQPVQYELQSLGDSNAQMMIVASPSENGQVLRVIPSPQTGMTQVIIPQGPLVDENSPQDVSEEKPSDRNLPAVRVDALADSNSSYVLHPQASLTLPKKTVTRILEEPLLAPLQPLSSNTPIWACRLRSCEKIGDSYRGYCVSETELESVLTFHKQQTQSVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKGFQLKKIGELENRSCQLYKATCPARIYIKKVQKFPDYRVPTDPKIDRKIIRMEQEKAFNLLKKNLVDAGGVLRWYVQLPTQQAHQYHELETPCLPLSSSSFPISSLEEEEAAIRDENCTLPSRLHPQVAHKIQELVSQGIEQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIRNHIHEVQKSLRNGDNICNSEIIPATLQWTTDSGNILRETVTVTLAEGNSQGESVSSKLETNQTRNSLSPEPAQLLSSLSSFQPKIFTHLQGLQLQPRFTSDGSPALISVNNHPSSSPSRLLDSVRSVVMNNNSLLLGQTHCLQTDTPLTPNSSISSTMSNLPGPDQNLVAVDQLVEVEDVEDTETLEGNVHRILLGNVQTIPIQIIDNPPVLSNFGSILKEPIFDCFGGPIKI", "length": 703, "header": "sp|Q58CW6-1|CARTF_BOVIN Isoform 1 of Calcium-responsive transcription factor OS=Bos taurus OX=9913 GN=CARF PE=2 SV=1 CANONICAL=Q58CW6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509072", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509072", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "Q58CW6", "url": "https://www.uniprot.org/uniprotkb/Q58CW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 531, "end_pos": 533, "annotation": "n_glycosylation_sequon" }, { "start_pos": 601, "end_pos": 603, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CW6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 703, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CW6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CW6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 163, "end_pos": 165 }, { "start_pos": 302, "end_pos": 304 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 531, "end_pos": 533 }, { "start_pos": 601, "end_pos": 603 }, { "start_pos": 621, "end_pos": 623 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CX7-1", "uniprot_ac": "Q58CX7", "uniprot_id": "DIK2B_BOVIN", "mass": { "chemical_mass": 48095.0, "monoisotopic_mass": 48095.0 }, "refseq": { "ac": "NP_001030572", "name": "divergent protein kinase domain 2B precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" }, "gene_names": [ { "name": "DIPK2B", "type": "recommended", "evidence": [ { "id": "Q58CX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX7" } ] }, { "name": "CXHXorf36", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] }, { "name": "CXORF36", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] }, { "name": "DIPK2B", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] } ], "protein_names": [ { "name": "Divergent protein kinase domain 2B", "type": "recommended", "evidence": [ { "id": "Q58CX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX7/entry#names_and_taxonomy" } ] }, { "name": "Deleted in autism-related protein 1 homolog", "type": "synonym", "evidence": [ { "id": "Q58CX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX7/entry#names_and_taxonomy" } ] }, { "name": "UPF0672 protein CXorf36 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] }, { "name": "chromosome X CXorf36 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] }, { "name": "deleted in autism-related protein 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] }, { "name": "divergent protein kinase domain 2B precursor", "type": "synonym", "evidence": [ { "id": "NP_001030572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CX7", "url": "https://www.uniprot.org/uniprotkb/Q58CX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIPK2B", "url": "https://www.uniprot.org/uniprotkb/Q58CX7", "locus": { "chromosome": "X", "start_pos": 98605072, "end_pos": 98556863, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020717", "url": "https://www.ensembl.org/id/ENSBTAG00000020717" } ] } } ], "crossref": [ { "id": "Q58CX7", "url": "https://alphafold.ebi.ac.uk/entry/Q58CX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "617391", "url": "https://www.ncbi.nlm.nih.gov/gene/617391", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617391", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617391", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CX7", "url": "https://www.orthodb.org/?gene=Q58CX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32073:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32073:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030572", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CX7", "url": "https://www.uniprot.org/uniprotkb/Q58CX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CX7-1", "url": "https://www.uniprot.org/uniprotkb/Q58CX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRLGPKAAALHLGWPFLLLWVSGLSYSVSSPASPSPSPVSRVRTSYNLGKTFLGLDKCNACIGTSICKKFFKEEIRFDNGLALHLGPPPDDLPSYSANYSDDFKTWRPVEISRLVSKQQNKISDGRICASAAAPKTCSIERVLRKTGRFQKWLQAKRLTPDLVRGLSSPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNTHPVLLQIFPGAEGWPLPQYLGSCGRFLVSTSTSPLQEFYGAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHVDADMFGIFNNGHLFIRDASALGVIDRQEGSQAASGAGDNKDIFSCLVSGCQTKLPSCDTIPEKQNLVLVCSQVLPLLLQAKFPSPVQEEIDAELTRCADGTRPDPEVLGAASRLKDILRPLRTCDPRFAYRYPDCKYDDKF", "length": 433, "header": "sp|Q58CX7-1|DIK2B_BOVIN Isoform 1 of Divergent protein kinase domain 2B OS=Bos taurus OX=9913 GN=DIPK2B PE=2 SV=1 CANONICAL=Q58CX7-1" }, "isoforms": [ { "isoform_ac": "Q58CX7-1", "url": "https://www.uniprot.org/uniprotkb/Q58CX7/entry#Q58CX7-1", "sequence": { "sequence": "MEPRLGPKAAALHLGWPFLLLWVSGLSYSVSSPASPSPSPVSRVRTSYNLGKTFLGLDKCNACIGTSICKKFFKEEIRFDNGLALHLGPPPDDLPSYSANYSDDFKTWRPVEISRLVSKQQNKISDGRICASAAAPKTCSIERVLRKTGRFQKWLQAKRLTPDLVRGLSSPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNTHPVLLQIFPGAEGWPLPQYLGSCGRFLVSTSTSPLQEFYGAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHVDADMFGIFNNGHLFIRDASALGVIDRQEGSQAASGAGDNKDIFSCLVSGCQTKLPSCDTIPEKQNLVLVCSQVLPLLLQAKFPSPVQEEIDAELTRCADGTRPDPEVLGAASRLKDILRPLRTCDPRFAYRYPDCKYDDKF", "length": 433, "header": "sp|Q58CX7-1|DIK2B_BOVIN Isoform 1 of Divergent protein kinase domain 2B OS=Bos taurus OX=9913 GN=DIPK2B PE=2 SV=1 CANONICAL=Q58CX7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 100, "start_aa": "Asn", "end_pos": 100, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn100", "evidence": [ { "id": "Q58CX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CX7", "url": "https://www.uniprot.org/uniprotkb/Q58CX7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:617391", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617391", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q58CX7", "url": "https://www.uniprot.org/uniprotkb/Q58CX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 433, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 100 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CY8-1", "uniprot_ac": "Q58CY8", "uniprot_id": "TSN18_BOVIN", "mass": { "chemical_mass": 27710.0, "monoisotopic_mass": 27710.0 }, "refseq": { "ac": "NP_001074389", "name": "tetraspanin-18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389" }, "gene_names": [ { "name": "TSPAN18", "type": "recommended", "evidence": [ { "id": "Q58CY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY8" } ] }, { "name": "TSPAN18", "type": "synonym", "evidence": [ { "id": "NP_001074389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389" } ] } ], "protein_names": [ { "name": "Tetraspanin-18", "type": "recommended", "evidence": [ { "id": "Q58CY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY8/entry#names_and_taxonomy" } ] }, { "name": "Tspan-18", "type": "synonym", "evidence": [ { "id": "Q58CY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY8/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin similiar to uroplakin 1", "type": "synonym", "evidence": [ { "id": "NP_001074389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389" } ] }, { "name": "tetraspanin-18", "type": "synonym", "evidence": [ { "id": "NP_001074389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389" } ] }, { "name": "tspan-18", "type": "synonym", "evidence": [ { "id": "NP_001074389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389" } ] } ], "function": [ { "annotation": "Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli.", "evidence": [ { "database": "UniProtKB", "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8#function" }, { "database": "UniProtKB", "id": "Q96SJ8", "url": "https://www.uniprot.org/uniprotkb/Q96SJ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN18", "url": "https://www.uniprot.org/uniprotkb/Q58CY8", "locus": { "chromosome": "15", "start_pos": 75003105, "end_pos": 74830510, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021484", "url": "https://www.ensembl.org/id/ENSBTAG00000021484" } ] } } ], "crossref": [ { "id": "Q58CY8", "url": "https://alphafold.ebi.ac.uk/entry/Q58CY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021484", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021484", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783765", "url": "https://www.ncbi.nlm.nih.gov/gene/783765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783765", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783765", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ACCQREP", "url": "https://omabrowser.org/oma/group/ACCQREP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58CY8", "url": "https://www.orthodb.org/?gene=Q58CY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001074389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074389", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CY8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFIFLGGACLLGIGIWVMVDPTGFREIVAANPLLITGAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRGNLTREFFTKELTKHYQGSNDTDVFSATWNSVMITFGCCGVNGPEDFKYASVFRLLTLDSDEVPEACCRREPQSRDGVLLSREECLLGRDLFLNKQGCYTVILNAFETYVYLAGALAIGVLAIELFAMIFAMCLFRGIIQ", "length": 249, "header": "sp|Q58CY8-1|TSN18_BOVIN Isoform 1 of Tetraspanin-18 OS=Bos taurus OX=9913 GN=TSPAN18 PE=2 SV=1 CANONICAL=Q58CY8-1" }, "isoforms": [ { "isoform_ac": "Q58CY8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CY8/entry#Q58CY8-1", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFIFLGGACLLGIGIWVMVDPTGFREIVAANPLLITGAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRGNLTREFFTKELTKHYQGSNDTDVFSATWNSVMITFGCCGVNGPEDFKYASVFRLLTLDSDEVPEACCRREPQSRDGVLLSREECLLGRDLFLNKQGCYTVILNAFETYVYLAGALAIGVLAIELFAMIFAMCLFRGIIQ", "length": 249, "header": "sp|Q58CY8-1|TSN18_BOVIN Isoform 1 of Tetraspanin-18 OS=Bos taurus OX=9913 GN=TSPAN18 PE=2 SV=1 CANONICAL=Q58CY8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 111, "start_aa": "Asn", "end_pos": 111, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn111", "evidence": [ { "id": "Q58CY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 129, "start_aa": "Asn", "end_pos": 129, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn129", "evidence": [ { "id": "Q58CY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CY8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:783765", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783765", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M5C9-1", "protein_name": "Tetraspanin", "gene_name": "Tspan18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFVFLGGACLLGVGIWVLVDPTGFREIVATNPLLTTGAYIVLAMGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFIFREHLTREFFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKTASVFRLLTLDSEEVPKACCRREPQTRDGMLLSREECQLGRSPFINKQGCYTVILNTFETYVYLAGAFAIGVLAIELFLMIFAMCLFRGIQ", "length": 248 }, "evidence": [ { "id": "Q58CY8", "url": "https://omabrowser.org/oma/group/Q58CY8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A3U2-1", "protein_name": "Tetraspanin", "gene_name": "Tspan18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFVFLGGACLLGVGIWVLVDPTGFREIVATNPLLTTGAYVVLAMGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFIFREHLTREFFTKELTKHYQGDNDTDVFSATWNSVMITFGCCGVNGPEDFKLASVFRLLTLDTEEVPKACCRREPQTRDGVVLSREECQLGRNPFINKQGCYTVILNTFETYVYLAGAFAIGVLAIELFLMVFAMCLFRGIQ", "length": 248 }, "evidence": [ { "id": "Q58CY8", "url": "https://omabrowser.org/oma/group/Q58CY8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SHI4-1", "protein_name": "Tetraspanin", "gene_name": "TSPAN18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFIFLGGACLLGVGIWVMVDPTGFREIVAANPLLITGAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRENLTREFFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSDEVPEACCRREPQSRDGVLLSREECLLGRELFLNKQGCYTVILNAFETYVYLAGALAIGVLAIELFAMIFAMCLFRGIQ", "length": 248 }, "evidence": [ { "id": "Q58CY8", "url": "https://omabrowser.org/oma/group/Q58CY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80WR1-1", "protein_name": "Tetraspanin-18", "gene_name": "Tspan18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFVFLGGACLLGVGIWVLVDPTGFREIVATNPLLTTGAYIVLAMGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFIFREHLTREFFTKELTKHYQGDNDTDVFSATWNSVMITFGCCGVNGPEDFKLASVFRLLTLDTEEVPKACCRREPQTRDGVVLSREECQLGRNPFINKQGCYTVILNTFETYVYLAGAFAIGVLAIELFLMVFAMCLFRGIQ", "length": 248 }, "evidence": [ { "id": "Q58CY8", "url": "https://omabrowser.org/oma/group/Q58CY8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96SJ8-1", "protein_name": "Tetraspanin-18", "gene_name": "TSPAN18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGDCLSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLTGAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRENLTREFFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEEVPEACCRREPQSRDGVLLSREECLLGRSLFLNKQGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFAMCLFRGIQ", "length": 248 }, "evidence": [ { "id": "Q58CY8", "url": "https://omabrowser.org/oma/group/Q58CY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of sprouting angiogenesis", "id": "GO:1903670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903670", "evidence": [ { "database": "UniProtKB", "id": "Q58CY8", "url": "https://www.uniprot.org/uniprotkb/Q58CY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CY8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 111, 129 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CZ0-1", "uniprot_ac": "Q58CZ0", "uniprot_id": "DFFB_BOVIN", "mass": { "chemical_mass": 38967.0, "monoisotopic_mass": 38967.0 }, "refseq": { "ac": "NP_001030281", "name": "DNA fragmentation factor subunit beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030281" }, "gene_names": [ { "name": "DFFB", "type": "recommended", "evidence": [ { "id": "Q58CZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ] }, { "name": "DFFB", "type": "synonym", "evidence": [ { "id": "NP_001030281", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030281" } ] } ], "protein_names": [ { "name": "DNA fragmentation factor subunit beta", "type": "recommended", "evidence": [ { "id": "Q58CZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0/entry#names_and_taxonomy" } ] }, { "name": "3.-.-.-", "type": "synonym", "evidence": [ { "id": "Q58CZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0/entry#names_and_taxonomy" } ] }, { "name": "DNA fragmentation factor subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001030281", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030281" } ] }, { "name": "DNA fragmentation factor, 40 kD, beta polypeptide", "type": "synonym", "evidence": [ { "id": "NP_001030281", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030281" } ] } ], "function": [ { "annotation": "Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DFFB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0", "locus": { "chromosome": "16", "start_pos": 49213744, "end_pos": 49228476, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020015", "url": "https://www.ensembl.org/id/ENSBTAG00000020015" } ] } } ], "crossref": [ { "id": "Q58CZ0", "url": "https://alphafold.ebi.ac.uk/entry/Q58CZ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "512730", "url": "https://www.ncbi.nlm.nih.gov/gene/512730", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512730", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512730", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CZ0", "url": "https://www.orthodb.org/?gene=Q58CZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13067", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13067", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13067:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13067:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030281", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAVLRKPKTFKLRSLHSEKKFGVAGRSCEEVLRKGCQRLQLPIPGSRLCLYEDGTELTGDYFWSAPDNSELVLLTAGQTWQGFVSDISRFLSVFQEPHAGVIQAARQLLWDERAPLRQKLLADLLGTVSENIAAETRAEDPPWFEGLESRFRSKSGYLRYSCESRIRSYLREVTSGASLVGAEAREEYLRLVGSMQQKLQAAQYNSSYFDRGAKAGRRLCTPEGWFSCQGPFDVDDCTSRHSINPYSNRESRVLFSTWNLDHVIEKKRVVVPALAAAVHDAEGREVDWEYFYRLLFTLENLKLVHIACHKKTTHKLHCDPSRVYCTPAAPRRKRHARHRL", "length": 341, "header": "sp|Q58CZ0-1|DFFB_BOVIN Isoform 1 of DNA fragmentation factor subunit beta OS=Bos taurus OX=9913 GN=DFFB PE=2 SV=1 CANONICAL=Q58CZ0-1" }, "isoforms": [ { "isoform_ac": "Q58CZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0/entry#Q58CZ0-1", "sequence": { "sequence": "MSAVLRKPKTFKLRSLHSEKKFGVAGRSCEEVLRKGCQRLQLPIPGSRLCLYEDGTELTGDYFWSAPDNSELVLLTAGQTWQGFVSDISRFLSVFQEPHAGVIQAARQLLWDERAPLRQKLLADLLGTVSENIAAETRAEDPPWFEGLESRFRSKSGYLRYSCESRIRSYLREVTSGASLVGAEAREEYLRLVGSMQQKLQAAQYNSSYFDRGAKAGRRLCTPEGWFSCQGPFDVDDCTSRHSINPYSNRESRVLFSTWNLDHVIEKKRVVVPALAAAVHDAEGREVDWEYFYRLLFTLENLKLVHIACHKKTTHKLHCDPSRVYCTPAAPRRKRHARHRL", "length": 341, "header": "sp|Q58CZ0-1|DFFB_BOVIN Isoform 1 of DNA fragmentation factor subunit beta OS=Bos taurus OX=9913 GN=DFFB PE=2 SV=1 CANONICAL=Q58CZ0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512730", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512730", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" }, { "name": "DNA endonuclease activity", "id": "GO:0004520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004520", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" }, { "name": "DNA nuclease activity", "id": "GO:0004536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004536", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic DNA fragmentation", "id": "GO:0006309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006309", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ0", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CZ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CZ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CZ0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ0" }, { "id": "PRU00447", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00447" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CIDE-N", "eco_id": "ECO_0000255", "start_pos": 7, "end_pos": 83, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D00-1", "uniprot_ac": "Q58D00", "uniprot_id": "FBXW2_BOVIN", "mass": { "chemical_mass": 51467.0, "monoisotopic_mass": 51467.0 }, "refseq": { "ac": "NP_001070442", "name": "F-box/WD repeat-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442" }, "gene_names": [ { "name": "FBXW2", "type": "recommended", "evidence": [ { "id": "Q58D00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D00" } ] }, { "name": "FBXW2", "type": "synonym", "evidence": [ { "id": "NP_001070442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442" } ] } ], "protein_names": [ { "name": "F-box/WD repeat-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q58D00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D00/entry#names_and_taxonomy" } ] }, { "name": "F-box and WD-40 domain protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442" } ] }, { "name": "F-box and WD-40 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442" }, { "id": "Q58D00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D00/entry#names_and_taxonomy" } ] }, { "name": "F-box/WD repeat-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "Q58D00", "url": "https://www.uniprot.org/uniprotkb/Q58D00#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D00", "url": "https://www.uniprot.org/uniprotkb/Q58D00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXW2", "url": "https://www.uniprot.org/uniprotkb/Q58D00", "locus": { "chromosome": "8", "start_pos": 110161751, "end_pos": 110188746, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000712", "url": "https://www.ensembl.org/id/ENSBTAG00000000712" } ] } } ], "crossref": [ { "id": "Q58D00", "url": "https://alphafold.ebi.ac.uk/entry/Q58D00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000712", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000712", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22131", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22131", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767863", "url": "https://www.ncbi.nlm.nih.gov/gene/767863", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767863", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767863", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TIACWDW", "url": "https://omabrowser.org/oma/group/TIACWDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D00", "url": "https://www.orthodb.org/?gene=Q58D00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44436", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44436", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44436:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44436:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D00", "url": "https://www.uniprot.org/uniprotkb/Q58D00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D00-1", "url": "https://www.uniprot.org/uniprotkb/Q58D00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYILDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 454, "header": "sp|Q58D00-1|FBXW2_BOVIN Isoform 1 of F-box/WD repeat-containing protein 2 OS=Bos taurus OX=9913 GN=FBXW2 PE=2 SV=1 CANONICAL=Q58D00-1" }, "isoforms": [ { "isoform_ac": "Q58D00-1", "url": "https://www.uniprot.org/uniprotkb/Q58D00/entry#Q58D00-1", "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYILDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 454, "header": "sp|Q58D00-1|FBXW2_BOVIN Isoform 1 of F-box/WD repeat-containing protein 2 OS=Bos taurus OX=9913 GN=FBXW2 PE=2 SV=1 CANONICAL=Q58D00-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D00", "url": "https://www.uniprot.org/uniprotkb/Q58D00" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:767863", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767863", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A9Z5-1", "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "FBXW2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSFNTILQTSLCIFFKHKAGKFLHNLMEKKDFEAWLDNISITFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLEILLKRDFLKLLPLELSFYLLKWLDPHTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDPLHWKKVYLKAILRMKQLKDHEAFETSSLIGHSARVYALYYRDGLLCTGSDDLSAKLWDVSTGQCIYGIQTHTCATVKFDEQKLVTGSFDNTVACWEWSSGAKTQHFRGHTGAVFSVDYNDELDVLVSGSADFTVKVWALSTGTCLNTLTGHTEWVTKVVLQKCKVKSLMHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSISLQPRLHFDGKYIVCSSALGLYQWDFASYDIVRVIKTSDFSNVSLLGFGEIFALLFDNRYLYIMDVRTEELISRWPLPEYRKSKRGSSFLAGEMSWLNGLNGQNDTGLVFATSMPDHSIHLVLWKEHG", "length": 480 }, "evidence": [ { "id": "Q58D00", "url": "https://omabrowser.org/oma/group/Q58D00/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RZ17-1", "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "Fbxw2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLQQCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEVANLALLGFGDVFALLFDNHYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 454 }, "evidence": [ { "id": "Q58D00", "url": "https://omabrowser.org/oma/group/Q58D00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q60584-1", "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "Fbxw2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDSLHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEVANLALLGFGDVFALLFDNHYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGERPG", "length": 422 }, "evidence": [ { "id": "Q58D00", "url": "https://omabrowser.org/oma/group/Q58D00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKT8-1", "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "FBXW2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 454 }, "evidence": [ { "id": "Q58D00", "url": "https://omabrowser.org/oma/group/Q58D00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 454, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D00" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58D00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D00" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 54, "end_pos": 101, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 430, "end_pos": 432 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D13-1", "uniprot_ac": "Q58D13", "uniprot_id": "DPOA2_BOVIN", "mass": { "chemical_mass": 66955.0, "monoisotopic_mass": 66955.0 }, "refseq": { "ac": "NP_001019713", "name": "DNA polymerase alpha subunit B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" }, "gene_names": [ { "name": "POLA2", "type": "recommended", "evidence": [ { "id": "Q58D13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ] }, { "name": "POLA2", "type": "synonym", "evidence": [ { "id": "NP_001019713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" } ] } ], "protein_names": [ { "name": "DNA polymerase alpha subunit B", "type": "recommended", "evidence": [ { "id": "Q58D13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D13/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase alpha 70 kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001019713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" }, { "id": "Q58D13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D13/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase alpha subunit B", "type": "synonym", "evidence": [ { "id": "NP_001019713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" } ] }, { "name": "polymerase (DNA directed), alpha 2 (70kD subunit)", "type": "synonym", "evidence": [ { "id": "NP_001019713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" } ] }, { "name": "polymerase (DNA directed), alpha 2, accessory subunit", "type": "synonym", "evidence": [ { "id": "NP_001019713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713" } ] } ], "function": [ { "annotation": "Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13#function" }, { "database": "UniProtKB", "id": "Q14181", "url": "https://www.uniprot.org/uniprotkb/Q14181#function" }, { "database": "UniProtKB", "id": "P20664", "url": "https://www.uniprot.org/uniprotkb/P20664#function" }, { "database": "UniProtKB", "id": "P09884", "url": "https://www.uniprot.org/uniprotkb/P09884#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLA2", "url": "https://www.uniprot.org/uniprotkb/Q58D13", "locus": { "chromosome": "29", "start_pos": 43504471, "end_pos": 43477546, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011455", "url": "https://www.ensembl.org/id/ENSBTAG00000011455" } ] } } ], "crossref": [ { "id": "Q58D13", "url": "https://alphafold.ebi.ac.uk/entry/Q58D13", "database": "AlphaFoldDB", "categories": [] }, { "id": "CHEMBL5259", "url": "https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL5259", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "514793", "url": "https://www.ncbi.nlm.nih.gov/gene/514793", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514793", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514793", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58D13", "url": "https://www.orthodb.org/?gene=Q58D13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23061", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23061", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23061:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23061:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08418", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08418", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q58D13", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q58D13", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001019713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019713", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D13-1", "url": "https://www.uniprot.org/uniprotkb/Q58D13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVSAQLLVEELQIFGLECEEAVIEKLVELCILYGQNEEGMASELIAFCTSTRKDCFTLETLNSFEHEFLSKRVSKTRHGASKDKGLRHAGARDIVSIQELIEVEEEEETLLNSYTTPSKGSQKRTITTPETPLTKRSVSARSPHQLLSPSSFSPSATPPQKYSSRSNRGEVVTSFGSAQGVSWSGRGGASPLSLKVLGHPEPLTGSYKYMFQKLPDIREVLTCKIEELGSELKEHYKIEAFAPILVPAQEPVTLLGQIGCDSNGKLNHKSVILEGDLEHSSGAQIPVDLSELKEYSLFPGQVVVMEGINTTGRKLVATRLYEGVPLPFHQPDEEDGDSEQFMVLVACGPYTTSDSITFDPLLDLITIINRDRPDVCILFGPFLDAKHEQVESCLLTSSFEDVFKQCLRTIIEGTRSSGSHLIIVPSLRDVHHEPVYPQPPFSCSDLLREDKKRVRLVSEPCTLSINGVIFGLTSTDLLFHMGAEEISSSSGTSDRFSRILRHILTQRSYYPLYPPQEDMAIDYENFYLYAQLPVTPDVFIAPSELRYFVKVGLNSAISLQCQNQFLSGALALNSSRVCWWGQWPRSFGGGVGVENKSVSIMLK", "length": 604, "header": "sp|Q58D13-1|DPOA2_BOVIN Isoform 1 of DNA polymerase alpha subunit B OS=Bos taurus OX=9913 GN=POLA2 PE=2 SV=1 CANONICAL=Q58D13-1" }, "isoforms": [ { "isoform_ac": "Q58D13-1", "url": "https://www.uniprot.org/uniprotkb/Q58D13/entry#Q58D13-1", "sequence": { "sequence": "MAVSAQLLVEELQIFGLECEEAVIEKLVELCILYGQNEEGMASELIAFCTSTRKDCFTLETLNSFEHEFLSKRVSKTRHGASKDKGLRHAGARDIVSIQELIEVEEEEETLLNSYTTPSKGSQKRTITTPETPLTKRSVSARSPHQLLSPSSFSPSATPPQKYSSRSNRGEVVTSFGSAQGVSWSGRGGASPLSLKVLGHPEPLTGSYKYMFQKLPDIREVLTCKIEELGSELKEHYKIEAFAPILVPAQEPVTLLGQIGCDSNGKLNHKSVILEGDLEHSSGAQIPVDLSELKEYSLFPGQVVVMEGINTTGRKLVATRLYEGVPLPFHQPDEEDGDSEQFMVLVACGPYTTSDSITFDPLLDLITIINRDRPDVCILFGPFLDAKHEQVESCLLTSSFEDVFKQCLRTIIEGTRSSGSHLIIVPSLRDVHHEPVYPQPPFSCSDLLREDKKRVRLVSEPCTLSINGVIFGLTSTDLLFHMGAEEISSSSGTSDRFSRILRHILTQRSYYPLYPPQEDMAIDYENFYLYAQLPVTPDVFIAPSELRYFVKVGLNSAISLQCQNQFLSGALALNSSRVCWWGQWPRSFGGGVGVENKSVSIMLK", "length": 604, "header": "sp|Q58D13-1|DPOA2_BOVIN Isoform 1 of DNA polymerase alpha subunit B OS=Bos taurus OX=9913 GN=POLA2 PE=2 SV=1 CANONICAL=Q58D13-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 158, "start_aa": "Thr", "end_pos": 158, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr158", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Thr129" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Thr132" }, { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Ser143" }, { "start_pos": 149, "end_pos": 149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Ser149" }, { "start_pos": 154, "end_pos": 154, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Ser154" }, { "start_pos": 156, "end_pos": 156, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "site_lbl": "Ser156" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514793", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514793", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "alpha DNA polymerase:primase complex", "id": "GO:0005658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005658", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "Q58D13", "url": "https://www.uniprot.org/uniprotkb/Q58D13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 596, "end_pos": 598, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 604, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D13" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 158 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 129, 132, 143, 149, 154, 156 ], "sequon_annotation_sites": [ { "start_pos": 310, "end_pos": 312 }, { "start_pos": 574, "end_pos": 576 }, { "start_pos": 596, "end_pos": 598 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D78-1", "uniprot_ac": "Q58D78", "uniprot_id": "CXB3_BOVIN", "mass": { "chemical_mass": 31016.0, "monoisotopic_mass": 31016.0 }, "refseq": { "ac": "NP_001098465", "name": "gap junction beta-3 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" }, "gene_names": [ { "name": "GJB3", "type": "recommended", "evidence": [ { "id": "Q58D78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ] }, { "name": "CXNC", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "GJB3", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] } ], "protein_names": [ { "name": "Gap junction beta-3 protein", "type": "recommended", "evidence": [ { "id": "Q58D78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D78/entry#names_and_taxonomy" } ] }, { "name": "Connexin-31", "type": "synonym", "evidence": [ { "id": "Q58D78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D78/entry#names_and_taxonomy" } ] }, { "name": "Cx31", "type": "synonym", "evidence": [ { "id": "Q58D78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D78/entry#names_and_taxonomy" } ] }, { "name": "connexin 31", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "connexin C", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "cx31", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "gap junction beta 3", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "gap junction beta-3 protein", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] }, { "name": "gap junction protein, beta 3, 31kDa", "type": "synonym", "evidence": [ { "id": "NP_001098465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465" } ] } ], "function": [ { "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GJB3", "url": "https://www.uniprot.org/uniprotkb/Q58D78", "locus": { "chromosome": "3", "start_pos": 110891948, "end_pos": 110906046, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064062", "url": "https://www.ensembl.org/id/ENSBTAG00000064062" } ] } } ], "crossref": [ { "id": "Q58D78", "url": "https://alphafold.ebi.ac.uk/entry/Q58D78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012584", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012584", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539935", "url": "https://www.ncbi.nlm.nih.gov/gene/539935", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539935", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539935", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFFPISN", "url": "https://omabrowser.org/oma/group/HFFPISN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D78", "url": "https://www.orthodb.org/?gene=Q58D78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098465", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D78-1", "url": "https://www.uniprot.org/uniprotkb/Q58D78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDEFFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCTKLYDDTGKKHGGLWWTYLLSLVFKLLIEFLFLYLLHTLWYGFGMPRLVQCANVAPCPNTVDCYIARPTEKKLFTYFMVGASAVCIVLTFCEICYLIFHRVVRSLHRKRQPGGRGHAPSASRASTCRCHHKLLEAGDLSPDSHDNKLCASAPTMTPI", "length": 270, "header": "sp|Q58D78-1|CXB3_BOVIN Isoform 1 of Gap junction beta-3 protein OS=Bos taurus OX=9913 GN=GJB3 PE=2 SV=2 CANONICAL=Q58D78-1" }, "isoforms": [ { "isoform_ac": "Q58D78-1", "url": "https://www.uniprot.org/uniprotkb/Q58D78/entry#Q58D78-1", "sequence": { "sequence": "MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDEFFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCTKLYDDTGKKHGGLWWTYLLSLVFKLLIEFLFLYLLHTLWYGFGMPRLVQCANVAPCPNTVDCYIARPTEKKLFTYFMVGASAVCIVLTFCEICYLIFHRVVRSLHRKRQPGGRGHAPSASRASTCRCHHKLLEAGDLSPDSHDNKLCASAPTMTPI", "length": 270, "header": "sp|Q58D78-1|CXB3_BOVIN Isoform 1 of Gap junction beta-3 protein OS=Bos taurus OX=9913 GN=GJB3 PE=2 SV=2 CANONICAL=Q58D78-1" }, "locus": { "chromosome": "3", "start_pos": 110901729, "end_pos": 110900920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101767.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101767.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075370.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075370.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539935", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539935", "resource": "KEGG Pathway" }, { "id": "R-BTA-190861", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ASC7-1", "protein_name": "Gap junction protein", "gene_name": "GJB3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDEFFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDHCAKLYDNAGKKHGGLWWTYLLSLIFKLIIEFLFLYLLHTLWYGFGMPRLVQCANVAPCPNIVDCYIARPTEKKLFTYFMVGASAVCIVLTFCEICYLIFHRIVRSLPKKRTPRGGSPPSSASRASTCRCHHKLVEAGELGPDSSDDKVQASAPSLTPI", "length": 270 }, "evidence": [ { "id": "Q58D78", "url": "https://omabrowser.org/oma/group/Q58D78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H9T5-1", "protein_name": "Gap junction protein", "gene_name": "Gjb3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERERKHRLKHGDQCAKLYSHPGKKHGGLWWTYLLSLIFKLIIELVFLYVLHRLWHGFTMPRLVQCAGVDPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEIFYLIFHRVMRGLSKVKSTKSSSSPKSSSRASTCRCHHKLLESEDPEPGNAKPRASAPSLTPI", "length": 268 }, "evidence": [ { "id": "Q58D78", "url": "https://omabrowser.org/oma/group/Q58D78/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75712-1", "protein_name": "Gap junction beta-3 protein", "gene_name": "GJB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAGKKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSASRASTCRCHHKLVEAGEVDPDPGNNKLQASAPNLTPI", "length": 270 }, "evidence": [ { "id": "Q58D78", "url": "https://omabrowser.org/oma/group/Q58D78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P25305-1", "protein_name": "Gap junction beta-3 protein", "gene_name": "Gjb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERERKHRQKHGEHCAKLYSHPGKKHGGLWWTYLFSLIFKLIIELVFLYVLHTLWHGFTMPRLVQCASVVPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEICYLIFHRIMRGLSKDKSTKSISSPKSSSRASTCRCHHKLLESGDLEAVPADDKLQASAPSLTPI", "length": 270 }, "evidence": [ { "id": "Q58D78", "url": "https://omabrowser.org/oma/group/Q58D78/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P28231-1", "protein_name": "Gap junction beta-3 protein", "gene_name": "Gjb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERERKHRQKHGEQCAKLYSHPGKKHGGLWWTYLFSLIFKLIIELVFLYVLHTLWHGFTMPRLVQCASIVPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEICYLIFHRIMRGISKGKSTKSISSPKSSSRASTCRCHHKLLESGDPEADPASEKLQASAPSLTPI", "length": 270 }, "evidence": [ { "id": "Q58D78", "url": "https://omabrowser.org/oma/group/Q58D78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "pmid": "" }, { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "Q58D78", "url": "https://www.uniprot.org/uniprotkb/Q58D78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 270, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D78" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D91-1", "uniprot_ac": "Q58D91", "uniprot_id": "CAR19_BOVIN", "mass": { "chemical_mass": 20560.0, "monoisotopic_mass": 20560.0 }, "refseq": { "ac": "NP_001029925", "name": "caspase recruitment domain-containing protein 19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" }, "gene_names": [ { "name": "CARD19", "type": "recommended", "evidence": [ { "id": "Q58D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ] }, { "name": "C8H9orf89", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] }, { "name": "C9orf89", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] }, { "name": "CARD19", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] } ], "protein_names": [ { "name": "Caspase recruitment domain-containing protein 19", "type": "recommended", "evidence": [ { "id": "Q58D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D91/entry#names_and_taxonomy" } ] }, { "name": "Bcl10-interacting CARD protein", "type": "synonym", "evidence": [ { "id": "Q58D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D91/entry#names_and_taxonomy" } ] }, { "name": "BinCARD", "type": "synonym", "evidence": [ { "id": "Q58D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D91/entry#names_and_taxonomy" } ] }, { "name": "bcl10-interacting CARD protein", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] }, { "name": "binCARD", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] }, { "name": "caspase recruitment domain-containing protein 19", "type": "synonym", "evidence": [ { "id": "NP_001029925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925" } ] } ], "function": [ { "annotation": "Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91#function" }, { "database": "UniProtKB", "id": "Q96LW7", "url": "https://www.uniprot.org/uniprotkb/Q96LW7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CARD19", "url": "https://www.uniprot.org/uniprotkb/Q58D91", "locus": { "chromosome": "8", "start_pos": 84497829, "end_pos": 84481914, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011202", "url": "https://www.ensembl.org/id/ENSBTAG00000011202" } ] } } ], "crossref": [ { "id": "Q58D91", "url": "https://alphafold.ebi.ac.uk/entry/Q58D91", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd13785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614217", "url": "https://www.ncbi.nlm.nih.gov/gene/614217", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614217", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614217", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58D91", "url": "https://www.orthodb.org/?gene=Q58D91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001029925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D91-1", "url": "https://www.uniprot.org/uniprotkb/Q58D91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLAAGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 183, "header": "sp|Q58D91-1|CAR19_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=2 SV=1 CANONICAL=Q58D91-1" }, "isoforms": [ { "isoform_ac": "Q58D91-1", "url": "https://www.uniprot.org/uniprotkb/Q58D91/entry#Q58D91-1", "sequence": { "sequence": "MTEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLAAGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 183, "header": "sp|Q58D91-1|CAR19_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=2 SV=1 CANONICAL=Q58D91-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614217", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614217", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58D91", "url": "https://www.uniprot.org/uniprotkb/Q58D91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D91-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 183, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D91-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D91" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DA4-1", "uniprot_ac": "Q58DA4", "uniprot_id": "TX261_BOVIN", "mass": { "chemical_mass": 21838.0, "monoisotopic_mass": 21838.0 }, "refseq": { "ac": "NP_001030377", "name": "protein TEX261", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377" }, "gene_names": [ { "name": "TEX261", "type": "recommended", "evidence": [ { "id": "Q58DA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ] }, { "name": "TEX261", "type": "synonym", "evidence": [ { "id": "NP_001030377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377" } ] } ], "protein_names": [ { "name": "Protein TEX261", "type": "recommended", "evidence": [ { "id": "Q58DA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA4/entry#names_and_taxonomy" } ] }, { "name": "protein TEX261", "type": "synonym", "evidence": [ { "id": "NP_001030377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377" } ] }, { "name": "testis expressed gene 261", "type": "synonym", "evidence": [ { "id": "NP_001030377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377" } ] }, { "name": "testis expressed sequence 261", "type": "synonym", "evidence": [ { "id": "NP_001030377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEX261", "url": "https://www.uniprot.org/uniprotkb/Q58DA4", "locus": { "chromosome": "11", "start_pos": 13436886, "end_pos": 13428958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002105", "url": "https://www.ensembl.org/id/ENSBTAG00000002105" } ] } } ], "crossref": [ { "id": "Q58DA4", "url": "https://alphafold.ebi.ac.uk/entry/Q58DA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "514869", "url": "https://www.ncbi.nlm.nih.gov/gene/514869", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514869", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514869", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DA4", "url": "https://www.orthodb.org/?gene=Q58DA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13144", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13144", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13144:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13144:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DA4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGVTLANVLPVCLALLPPPAAGLYYLAELIEEYTVATSRIIKYMIWFSTAVLIGLYVFERFPTYMIGVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGLVVVNHYLAFQFFAEEYYPFSEVLAYFTFCLWIIPFAFFVSLSAGENVLPSTMQPGDDVVSNYFTKGKRGKRLGILVVFSFIKEAILPSRQKIY", "length": 193, "header": "sp|Q58DA4-1|TX261_BOVIN Isoform 1 of Protein TEX261 OS=Bos taurus OX=9913 GN=TEX261 PE=2 SV=1 CANONICAL=Q58DA4-1" }, "isoforms": [ { "isoform_ac": "Q58DA4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA4/entry#Q58DA4-1", "sequence": { "sequence": "MVGVTLANVLPVCLALLPPPAAGLYYLAELIEEYTVATSRIIKYMIWFSTAVLIGLYVFERFPTYMIGVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGLVVVNHYLAFQFFAEEYYPFSEVLAYFTFCLWIIPFAFFVSLSAGENVLPSTMQPGDDVVSNYFTKGKRGKRLGILVVFSFIKEAILPSRQKIY", "length": 193, "header": "sp|Q58DA4-1|TX261_BOVIN Isoform 1 of Protein TEX261 OS=Bos taurus OX=9913 GN=TEX261 PE=2 SV=1 CANONICAL=Q58DA4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514869", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514869", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "COPII receptor activity", "id": "GO:0097020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097020", "evidence": [ { "database": "UniProtKB", "id": "Q58DA4", "url": "https://www.uniprot.org/uniprotkb/Q58DA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 193, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DA4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DB0-1", "uniprot_ac": "Q58DB0", "uniprot_id": "PLD3B_BOVIN", "mass": { "chemical_mass": 21520.0, "monoisotopic_mass": 21520.0 }, "refseq": { "ac": "NP_001030553", "name": "PRELI domain containing protein 3B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" }, "gene_names": [ { "name": "PRELID3B", "type": "recommended", "evidence": [ { "id": "Q58DB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ] }, { "name": "C20ORF45", "type": "synonym", "evidence": [ { "id": "NP_001030553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" } ] }, { "name": "PRELID3B", "type": "synonym", "evidence": [ { "id": "NP_001030553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" } ] }, { "name": "SLMO2", "type": "synonym", "evidence": [ { "id": "NP_001030553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" }, { "id": "Q58DB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ] } ], "protein_names": [ { "name": "PRELI domain containing protein 3B", "type": "recommended", "evidence": [ { "id": "Q58DB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB0/entry#names_and_taxonomy" } ] }, { "name": "PRELI domain containing protein 3B", "type": "synonym", "evidence": [ { "id": "NP_001030553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" } ] }, { "name": "Protein slowmo homolog 2", "type": "synonym", "evidence": [ { "id": "Q58DB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB0/entry#names_and_taxonomy" } ] }, { "name": "protein slowmo homolog 2", "type": "synonym", "evidence": [ { "id": "NP_001030553", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRELID3B", "url": "https://www.uniprot.org/uniprotkb/Q58DB0", "locus": { "chromosome": "13", "start_pos": 57356298, "end_pos": 57347406, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004402", "url": "https://www.ensembl.org/id/ENSBTAG00000004402" } ] } } ], "crossref": [ { "id": "Q58DB0", "url": "https://alphafold.ebi.ac.uk/entry/Q58DB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004402", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004402", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616523", "url": "https://www.ncbi.nlm.nih.gov/gene/616523", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616523", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616523", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCPWNEK", "url": "https://omabrowser.org/oma/group/YCPWNEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DB0", "url": "https://www.orthodb.org/?gene=Q58DB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030553", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DB0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 194, "header": "sp|Q58DB0-1|PLD3B_BOVIN Isoform 1 of PRELI domain containing protein 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=2 SV=1 CANONICAL=Q58DB0-1" }, "isoforms": [ { "isoform_ac": "Q58DB0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB0/entry#Q58DB0-1", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 194, "header": "sp|Q58DB0-1|PLD3B_BOVIN Isoform 1 of PRELI domain containing protein 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=2 SV=1 CANONICAL=Q58DB0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 46, "end_pos": 46, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "site_lbl": "Ser46" }, { "start_pos": 51, "end_pos": 51, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "site_lbl": "Ser51" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616523", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616523", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZPP1-1", "protein_name": "PRELI/MSF1 domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDASGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVAKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTVLTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 194 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P35200-1", "protein_name": "Protein UPS2, mitochondrial", "gene_name": "UPS2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKLFQNSYDFNYPWDQVTAANWKKYPNEISTHVIAVDVLRRELKDQGKVLVTERLITVKQGVPKWIMMMLGGTNMSHVREVSVVDLNKKSLTMRSCNLTMCNLLKVYETVTYSPHPDDSANKTLFQQEAQITAYGSIRKLCNKMEDWSVQRFCENAKKGKMGFDAVLQVFSENWEKHVDDLSNQLVSKVNETMEDVKISAGTLLKGTERSGRTILQQNIDLFRDAYNHEN", "length": 230 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54G07-1", "protein_name": "Protein slowmo homolog", "gene_name": "slmo", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPLFETIKHTYKHLWSDASTASFRKYPSPERPDILSIDILSKEIDPTTGVLKCTKLIICKGNTPSWLKSILGSGECLFYEETTVDPKNKIMTLKTKNLNFTNILGVDEVCTYEQHPDNEEWTLFTQEATVTSSIFGVARKMEAFCLDRFVANAGKGRKIMEDTIIKVQKEAEESLASFDKTFTSIKHEAEQSFEKAFSTAEDILPIIKLDDKQSQTTQNTQSNNNKKK", "length": 228 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P9U4-1", "protein_name": "PRELI domain containing protein 3B", "gene_name": "Prelid3b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHVDPSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPIRRTMELKSTNISFTNMVSVDERLTYKPHPQDPEKTVLTQEALITVKGVSLSSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELAASARGSIRTPMAAAAALVDK", "length": 195 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CYY7-1", "protein_name": "PRELI domain containing protein 3B", "gene_name": "Prelid3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHVDPSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPVTRTMELKSTNISFTNMVSVDERLTYKPHLQDPEKTVLTQEALITVKGVSLSSYLEGLMASTISSNASKGREAMEWVIHKLNAEIEELAASARGSIRTPMAAAAALVDK", "length": 195 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FYA3-1", "protein_name": "MSF1-like family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVKAYRQEHVYKHPWERVSAASWRKFADPENKRILSHILEVDTLNRKLDTETGKLHTTRALTIHAPGPWFLHRIIGQDICHCVESTVVDGKSRSMQLTTKNISLKKFIEVEERIRYDPHPDNPSAWTVCSQETSIRIKPLSALASMAEKVEQKCAEKFMQNSAKGREVMERICKYMEAESARI", "length": 183 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V3U9-1", "protein_name": "Protein slowmo", "gene_name": "slmo", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKIWTSEHIFNHPWETVTQAAWRKYPNPMTPSIIGTDVVERRVVDGVLHTHRLVQSKWYFPKWTHALIGTAKTCFASERSTVDPERKQMVLKTNNLTFCRNISVDEVLYYEPHPSDASKTLLKQEATVTVFGVPLSHYMEDLLTSTISTNAGKGRQGLEWVIGLINTEVKGIARGTDELLHNTRRSIDEVTESARKSMDEISAQAAKAAKAMHIT", "length": 215 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3B1-1", "protein_name": "PRELI domain containing protein 3B", "gene_name": "PRELID3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTVLTQEAIITVKGVSLSSYLEGLMASTISSNASKGREAMEWVIHKLNAEIEELTASARGTIRTPMAAAAFAEK", "length": 194 }, "evidence": [ { "id": "Q58DB0", "url": "https://omabrowser.org/oma/group/Q58DB0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidic acid transfer activity", "id": "GO:1990050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990050", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid transport", "id": "GO:0015914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015914", "evidence": [ { "database": "UniProtKB", "id": "Q58DB0", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DB0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DB0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DB0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB0" }, { "id": "PRU00158", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PRELI/MSF1", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 172, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 46, 51 ], "sequon_annotation_sites": [ { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DC2-1", "uniprot_ac": "Q58DC2", "uniprot_id": "DCAF4_BOVIN", "mass": { "chemical_mass": 55024.0, "monoisotopic_mass": 55024.0 }, "refseq": { "ac": "NP_001019691", "name": "DDB1- and CUL4-associated factor 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" }, "gene_names": [ { "name": "DCAF4", "type": "recommended", "evidence": [ { "id": "Q58DC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ] }, { "name": "DCAF4", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" } ] }, { "name": "WDR21A", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" }, { "id": "Q58DC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ] }, { "name": "WDR21", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" } ] } ], "protein_names": [ { "name": "DDB1- and CUL4-associated factor 4", "type": "recommended", "evidence": [ { "id": "Q58DC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC2/entry#names_and_taxonomy" } ] }, { "name": "DDB1- and CUL4-associated factor 4", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" } ] }, { "name": "WD repeat domain 21A", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" } ] }, { "name": "WD repeat-containing protein 21A", "type": "synonym", "evidence": [ { "id": "NP_001019691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691" }, { "id": "Q58DC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCAF4", "url": "https://www.uniprot.org/uniprotkb/Q58DC2", "locus": {} } ], "crossref": [ { "id": "Q58DC2", "url": "https://alphafold.ebi.ac.uk/entry/Q58DC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "511629", "url": "https://www.ncbi.nlm.nih.gov/gene/511629", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511629", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511629", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DC2", "url": "https://www.orthodb.org/?gene=Q58DC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44472", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44472", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44472:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44472:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23761", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23761", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019691", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DC2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHQSSWKSRRHRRRGHRHSAWFRQHGSNERKDAGAQQSPQGSSDGHGEAPSTSSTAGSSSVPDLPGYYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMERKRLRLLEEEEQQGKKIARLGFNASSLLQKSKLGFLNATSYCRLAHELQVSCMQRKKVQIQSSDPSALASDQFNLIMADTNSDRLFTVNDVKVGGSKYGIISLHGLKTPTFRVHMHENLYFTNRKVNAMCWASLNHLDSHVLLCLMGIAETPGCATLLPTSLFVSNHAAGDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLVTSVVTGHRQSFGTSSDVLTQQFAVTAPLLFNGCRSGEIFAIDLRCQNQGKGWKATCLFHDSAVTSVQILQEEQCLMASDMAGTIKLWDLRTTKCIRQYEGHVNEYAHLPLHVHEEEGIMVAVGQDCYTRIWSLHDGQLLRTIPSPYPTSKADIPSVAFSSRLGGARGAPGLLMAVRQDLYCFSYS", "length": 494, "header": "sp|Q58DC2-1|DCAF4_BOVIN Isoform 1 of DDB1- and CUL4-associated factor 4 OS=Bos taurus OX=9913 GN=DCAF4 PE=2 SV=1 CANONICAL=Q58DC2-1" }, "isoforms": [ { "isoform_ac": "Q58DC2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC2/entry#Q58DC2-1", "sequence": { "sequence": "MHQSSWKSRRHRRRGHRHSAWFRQHGSNERKDAGAQQSPQGSSDGHGEAPSTSSTAGSSSVPDLPGYYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMERKRLRLLEEEEQQGKKIARLGFNASSLLQKSKLGFLNATSYCRLAHELQVSCMQRKKVQIQSSDPSALASDQFNLIMADTNSDRLFTVNDVKVGGSKYGIISLHGLKTPTFRVHMHENLYFTNRKVNAMCWASLNHLDSHVLLCLMGIAETPGCATLLPTSLFVSNHAAGDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLVTSVVTGHRQSFGTSSDVLTQQFAVTAPLLFNGCRSGEIFAIDLRCQNQGKGWKATCLFHDSAVTSVQILQEEQCLMASDMAGTIKLWDLRTTKCIRQYEGHVNEYAHLPLHVHEEEGIMVAVGQDCYTRIWSLHDGQLLRTIPSPYPTSKADIPSVAFSSRLGGARGAPGLLMAVRQDLYCFSYS", "length": 494, "header": "sp|Q58DC2-1|DCAF4_BOVIN Isoform 1 of DDB1- and CUL4-associated factor 4 OS=Bos taurus OX=9913 GN=DCAF4 PE=2 SV=1 CANONICAL=Q58DC2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511629", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511629", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "evidence": [ { "database": "UniProtKB", "id": "Q58DC2", "url": "https://www.uniprot.org/uniprotkb/Q58DC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 494, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DC2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DC7-1", "uniprot_ac": "Q58DC7", "uniprot_id": "MT21E_BOVIN", "mass": { "chemical_mass": 33336.0, "monoisotopic_mass": 33336.0 }, "refseq": { "ac": "NP_001014922", "name": "protein-lysine methyltransferase METTL21E", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" }, "gene_names": [ { "name": "METTL21E", "type": "recommended", "evidence": [ { "id": "Q58DC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC7" } ] }, { "name": "METTL21E", "type": "synonym", "evidence": [ { "id": "NP_001014922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" } ] } ], "protein_names": [ { "name": "Protein-lysine methyltransferase METTL21E", "type": "recommended", "evidence": [ { "id": "Q58DC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.-", "type": "synonym", "evidence": [ { "id": "Q58DC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC7/entry#names_and_taxonomy" } ] }, { "name": "Methyltransferase-like protein 21E", "type": "synonym", "evidence": [ { "id": "Q58DC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC7/entry#names_and_taxonomy" } ] }, { "name": "methyltransferase-like protein 21C pseudogene 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001014922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" } ] }, { "name": "methyltransferase-like protein 21E pseudogene homolog", "type": "synonym", "evidence": [ { "id": "NP_001014922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" } ] }, { "name": "methyltransferase-like protein LOC121952 homolog", "type": "synonym", "evidence": [ { "id": "NP_001014922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" } ] }, { "name": "protein-lysine methyltransferase METTL21E", "type": "synonym", "evidence": [ { "id": "NP_001014922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922" } ] } ], "function": [ { "annotation": "Protein-lysine methyltransferase.", "evidence": [ { "database": "UniProtKB", "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL21E", "url": "https://www.uniprot.org/uniprotkb/Q58DC7", "locus": {} } ], "crossref": [ { "id": "Q58DC7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513822", "url": "https://www.ncbi.nlm.nih.gov/gene/513822", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513822", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513822", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DC7", "url": "https://www.orthodb.org/?gene=Q58DC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14614:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14614:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DC7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILFNLLETQLTRVHSFQEMIKKASVYRHPLANHLMDPEVQKESREDGDDRTVVAEIMRRCFVPAFVTTIPWEGFHFAGHEIRINEATDCYGAVVWPSALVLCYFLETNVKQYNLVDKNVIEIGAGTGLVSIVASLLGAHVTATDLPELLGNLQYNISRNTKTKAKHLPQVKELSWGVALDKNFPRASINFDYILAADVVYAHPFLEELLVTFDHLCKETTVILWVMKFRLEKENKFVDRFEQLFDLEEISSFPSLNIKLYKAMKKNQKSACYPQRRMWKAKPISGRLLL", "length": 290, "header": "sp|Q58DC7-1|MT21E_BOVIN Isoform 1 of Protein-lysine methyltransferase METTL21E OS=Bos taurus OX=9913 GN=METTL21E PE=2 SV=1 CANONICAL=Q58DC7-1" }, "isoforms": [ { "isoform_ac": "Q58DC7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC7/entry#Q58DC7-1", "sequence": { "sequence": "MILFNLLETQLTRVHSFQEMIKKASVYRHPLANHLMDPEVQKESREDGDDRTVVAEIMRRCFVPAFVTTIPWEGFHFAGHEIRINEATDCYGAVVWPSALVLCYFLETNVKQYNLVDKNVIEIGAGTGLVSIVASLLGAHVTATDLPELLGNLQYNISRNTKTKAKHLPQVKELSWGVALDKNFPRASINFDYILAADVVYAHPFLEELLVTFDHLCKETTVILWVMKFRLEKENKFVDRFEQLFDLEEISSFPSLNIKLYKAMKKNQKSACYPQRRMWKAKPISGRLLL", "length": 290, "header": "sp|Q58DC7-1|MT21E_BOVIN Isoform 1 of Protein-lysine methyltransferase METTL21E OS=Bos taurus OX=9913 GN=METTL21E PE=2 SV=1 CANONICAL=Q58DC7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513822", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513822", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein methyltransferase activity", "id": "GO:0008276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008276", "evidence": [ { "database": "UniProtKB", "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q58DC7", "url": "https://www.uniprot.org/uniprotkb/Q58DC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DC7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DC7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DC7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DE2-1", "uniprot_ac": "Q58DE2", "uniprot_id": "MSTRO_BOVIN", "mass": { "chemical_mass": 30324.0, "monoisotopic_mass": 30324.0 }, "refseq": { "ac": "NP_001029724", "name": "protein maestro", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029724" }, "gene_names": [ { "name": "MRO", "type": "recommended", "evidence": [ { "id": "Q58DE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DE2" } ] }, { "name": "MRO", "type": "synonym", "evidence": [ { "id": "NP_001029724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029724" } ] } ], "protein_names": [ { "name": "Protein maestro", "type": "recommended", "evidence": [ { "id": "Q58DE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#names_and_taxonomy" } ] }, { "name": "Male-specific transcription in the developing reproductive organs", "type": "synonym", "evidence": [ { "id": "Q58DE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#names_and_taxonomy" } ] }, { "name": "male-specific transcription in the developing reproductive organs", "type": "synonym", "evidence": [ { "id": "NP_001029724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029724" } ] }, { "name": "protein maestro", "type": "synonym", "evidence": [ { "id": "NP_001029724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029724" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DE2", "url": "https://www.uniprot.org/uniprotkb/Q58DE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRO", "url": "https://www.uniprot.org/uniprotkb/Q58DE2", "locus": { "chromosome": "24", "start_pos": 50318709, "end_pos": 50343196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047635", "url": "https://www.ensembl.org/id/ENSBTAG00000047635" } ] } } ], "crossref": [ { "id": "Q58DE2", "url": "https://alphafold.ebi.ac.uk/entry/Q58DE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524917", "url": "https://www.ncbi.nlm.nih.gov/gene/524917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524917", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524917", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMMSFFS", "url": "https://omabrowser.org/oma/group/PMMSFFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DE2", "url": "https://www.orthodb.org/?gene=Q58DE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23120:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23120:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A986", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A986", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A986-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A986-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N261", "url": "https://www.uniprot.org/uniprotkb/G3N261", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N261-1", "url": "https://www.uniprot.org/uniprotkb/G3N261-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DE2", "url": "https://www.uniprot.org/uniprotkb/Q58DE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DE2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 263, "header": "sp|Q58DE2-1|MSTRO_BOVIN Isoform 1 of Protein maestro OS=Bos taurus OX=9913 GN=MRO PE=2 SV=1 CANONICAL=Q58DE2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#A0AAA9RXZ7-1", "sequence": { "sequence": "MCSLSSMDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 269, "header": "tr|A0AAA9RXZ7-1|A0AAA9RXZ7_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50335465, "end_pos": 50320343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113391.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113391.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076011.1" } ] } }, { "isoform_ac": "A0AAA9S1D5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#A0AAA9S1D5-1", "sequence": { "sequence": "MQTDGSCFRCRESETLETGSGNLCFNRSSSSMDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 294, "header": "tr|A0AAA9S1D5-1|A0AAA9S1D5_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50334129, "end_pos": 50320343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087968.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087968.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079687.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079687.1" } ] } }, { "isoform_ac": "A0AAA9T0D9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#A0AAA9T0D9-1", "sequence": { "sequence": "MRTNAAEVSREYDGPQALFHGPNTEKNAGPAPFQPRHPAQEEKHISDVFLFQETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 261, "header": "tr|A0AAA9T0D9-1|A0AAA9T0D9_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50336600, "end_pos": 50320343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125319.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125319.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092231.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092231.1" } ] } }, { "isoform_ac": "A0AAA9T7N2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#A0AAA9T7N2-1", "sequence": { "sequence": "MDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLSHYHPELLQFFYANKIL", "length": 196, "header": "tr|A0AAA9T7N2-1|A0AAA9T7N2_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50329473, "end_pos": 50319810, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094744.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094744.1" } ] } }, { "isoform_ac": "A0AAF7A986-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#A0AAF7A986-1", "sequence": { "sequence": "MSLGSPYQRVDIPFVKLCSMDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 282, "header": "tr|A0AAF7A986-1|A0AAF7A986_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50337812, "end_pos": 50320343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074752.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074752.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065167.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065167.2" } ] } }, { "isoform_ac": "G3N261-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#G3N261-1", "sequence": { "sequence": "MDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLSHYHPELLQFFYANKIL", "length": 248, "header": "tr|G3N261-1|G3N261_BOVIN Computationally mapped isoform of Maestro OS=Bos taurus OX=9913 GN=MRO PE=4 SV=1 CANONICAL=Q58DE2-1" }, "locus": { "chromosome": "24", "start_pos": 50329473, "end_pos": 50319810, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064436.2", "url": "https://www.ensembl.org/id/ENSBTAT00000064436.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000055968.1" } ] } }, { "isoform_ac": "Q58DE2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DE2/entry#Q58DE2-1", "sequence": { "sequence": "MDQTPRRMLGQPLSSPATQPKKRSTSVMSFFSKVSWNLRLQKQEPLKNVFFILAETARDPSVKKRHMVMRGLGTMACETPDKVRKYKKIILDLLVHGLYDPVSSEVIHESMKTLTIILGKMQGKALGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLADLAGRKWKSFFTRQVKQTQDSLLTHLQDRNPQVAKACKTTFRACSPYLRQSKDYSFQNEEDQRNPKLCRQLVSERGQETFFQSLRSRCRCKAEGGRHTRELPP", "length": 263, "header": "sp|Q58DE2-1|MSTRO_BOVIN Isoform 1 of Protein maestro OS=Bos taurus OX=9913 GN=MRO PE=2 SV=1 CANONICAL=Q58DE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DE2", "url": "https://www.uniprot.org/uniprotkb/Q58DE2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:524917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524917", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXW1-1", "protein_name": "Maestro", "gene_name": "Mro", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "SPQNCRSFWRKCARVRTGGISKGQEQQAAGRRHLGSLERKGAASWAEEGQPCGCHWRAVPSPTSPPRTGGSSLSLICLAFLCSAGSKFREDLLASLFVGKETRAGKISLTHHIWRPIPNRWNNAPPERPRTSLQPRNSGSSRDSHPRSQFHGTNAENPEPAPPHPCFSVQEEEDTTVIFLFQERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEILLFFYANKIL", "length": 376 }, "evidence": [ { "id": "Q58DE2", "url": "https://omabrowser.org/oma/group/Q58DE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TNB4-1", "protein_name": "Protein maestro", "gene_name": "Mro", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQTRKIPNQPLPTPTSQSKKRRTPLLSFLSKVSWKLRLQKRELLKNALFVLAERARDPNAKKRHLAMRGLGALAREAPDKQVRKYKKVMLDLLVRGLYDPVSSEVIHESVKTLTIMLGKIQGHGLGSFFIDITLQARTLLDDEDDSVRYSAFVLFGQLASFAGWRWKKFFTQQVNQTQDSLLGHLQDESPKVAKACKMTVRACVPYLKPRKVPSFQSEEEQKNHRLSRQLSHCHPEILLFFYANKIL", "length": 248 }, "evidence": [ { "id": "Q58DE2", "url": "https://omabrowser.org/oma/group/Q58DE2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BYG7-1", "protein_name": "Protein maestro", "gene_name": "MRO", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDQRQRRILGQPLSIPTSQPKQKRTSMISFFSKVSWKLRFQKREPLKNVFFILAERARDPSAKKRHMAMRNLGTMAYEAPDKVRKYKKIVLDLLVYGLYDPVNLEVIHESMKTLTVVLGKIQGKGLGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLAAFAGRKWKKFFTSQVKQTRDSLLIHLQDRNPQVAKACKTTFQACSPYLKLKEEYSFQSEEDQRNTKLYQQLSHYHPEILQFFYANKIL", "length": 248 }, "evidence": [ { "id": "Q58DE2", "url": "https://omabrowser.org/oma/group/Q58DE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DE2", "url": "https://www.uniprot.org/uniprotkb/Q58DE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DF7-1", "uniprot_ac": "Q58DF7", "uniprot_id": "KCD11_BOVIN", "mass": { "chemical_mass": 26015.0, "monoisotopic_mass": 26015.0 }, "refseq": {}, "gene_names": [ { "name": "KCTD11", "type": "recommended", "evidence": [ { "id": "Q58DF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD11", "type": "recommended", "evidence": [ { "id": "Q58DF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF7/entry#names_and_taxonomy" } ] }, { "name": "KCASH1 protein", "type": "synonym", "evidence": [ { "id": "Q58DF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF7/entry#names_and_taxonomy" } ] }, { "name": "Potassium channel tetramerization domain-containing protein 11", "type": "synonym", "evidence": [ { "id": "Q58DF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF7/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase subunit KCTD11", "type": "synonym", "evidence": [ { "id": "Q58DF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7#function" }, { "database": "UniProtKB", "id": "Q693B1", "url": "https://www.uniprot.org/uniprotkb/Q693B1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD11", "url": "https://www.uniprot.org/uniprotkb/Q58DF7", "locus": { "chromosome": "19", "start_pos": 27055058, "end_pos": 27052574, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010532", "url": "https://www.ensembl.org/id/ENSBTAG00000010532" } ] } } ], "crossref": [ { "id": "Q58DF7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "539167", "url": "https://www.ncbi.nlm.nih.gov/gene/539167", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539167", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539167", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DF7", "url": "https://www.orthodb.org/?gene=Q58DF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19329", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19329", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DF7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGAMFRAGTPMTPNLNPEGGGHYFIDRDGKAFRHILNFLRLGRLDLPLGYGETALLRAEADFYQIRPLLDALRELEASRGTPAPTAALLHADVDSSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDPECLGALRARFGVTNEDRAEGGPHFRLEWAPRPAELPEVEYRRLGLQPLWTGAPGEPRDVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH", "length": 232, "header": "sp|Q58DF7-1|KCD11_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD11 OS=Bos taurus OX=9913 GN=KCTD11 PE=2 SV=2 CANONICAL=Q58DF7-1" }, "isoforms": [ { "isoform_ac": "Q58DF7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF7/entry#Q58DF7-1", "sequence": { "sequence": "MLGAMFRAGTPMTPNLNPEGGGHYFIDRDGKAFRHILNFLRLGRLDLPLGYGETALLRAEADFYQIRPLLDALRELEASRGTPAPTAALLHADVDSSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDPECLGALRARFGVTNEDRAEGGPHFRLEWAPRPAELPEVEYRRLGLQPLWTGAPGEPRDVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH", "length": 232, "header": "sp|Q58DF7-1|KCD11_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD11 OS=Bos taurus OX=9913 GN=KCTD11 PE=2 SV=2 CANONICAL=Q58DF7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 86, "start_aa": "Thr", "end_pos": 86, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr86", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539167", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539167", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of neuron differentiation", "id": "GO:0045666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045666", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "Q58DF7", "url": "https://www.uniprot.org/uniprotkb/Q58DF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 232, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 86 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DI9-1", "uniprot_ac": "Q58DI9", "uniprot_id": "ARL11_BOVIN", "mass": { "chemical_mass": 19724.0, "monoisotopic_mass": 19724.0 }, "refseq": {}, "gene_names": [ { "name": "ARL11", "type": "recommended", "evidence": [ { "id": "Q58DI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 11", "type": "recommended", "evidence": [ { "id": "Q58DI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in apoptosis. May act as a tumor suppressor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL11", "url": "https://www.uniprot.org/uniprotkb/Q58DI9", "locus": { "chromosome": "12", "start_pos": 19197289, "end_pos": 19179769, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016998", "url": "https://www.ensembl.org/id/ENSBTAG00000016998" } ] } } ], "crossref": [ { "id": "Q58DI9", "url": "https://alphafold.ebi.ac.uk/entry/Q58DI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q58DI9", "url": "https://www.orthodb.org/?gene=Q58DI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DI9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSVSSRGHRAEAQVVMMGLDSAGKTTLLYRLKGYQLVETLPTVGFNVEPLEEPGHVSLTLWDVGGQSQLRASWKDHLEGTDILVYVLDSTDEARLPEAVAELREVLDDPSVASVPLLVLANKQEVPQALSLPEIRDRLGLQGFLGRSWDLRACSALTGAGLPEALESLRSLLKSCSLCMAR", "length": 182, "header": "sp|Q58DI9-1|ARL11_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=2 SV=1 CANONICAL=Q58DI9-1" }, "isoforms": [ { "isoform_ac": "Q58DI9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DI9/entry#Q58DI9-1", "sequence": { "sequence": "MGSVSSRGHRAEAQVVMMGLDSAGKTTLLYRLKGYQLVETLPTVGFNVEPLEEPGHVSLTLWDVGGQSQLRASWKDHLEGTDILVYVLDSTDEARLPEAVAELREVLDDPSVASVPLLVLANKQEVPQALSLPEIRDRLGLQGFLGRSWDLRACSALTGAGLPEALESLRSLLKSCSLCMAR", "length": 182, "header": "sp|Q58DI9-1|ARL11_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=2 SV=1 CANONICAL=Q58DI9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q58DI9", "url": "https://www.uniprot.org/uniprotkb/Q58DI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 182, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DI9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DR6-1", "uniprot_ac": "Q58DR6", "uniprot_id": "EMP3_BOVIN", "mass": { "chemical_mass": 18300.0, "monoisotopic_mass": 18300.0 }, "refseq": { "ac": "NP_001019733", "name": "epithelial membrane protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019733" }, "gene_names": [ { "name": "EMP3", "type": "recommended", "evidence": [ { "id": "Q58DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ] }, { "name": "EMP3", "type": "synonym", "evidence": [ { "id": "NP_001019733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019733" } ] } ], "protein_names": [ { "name": "Epithelial membrane protein 3", "type": "recommended", "evidence": [ { "id": "Q58DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DR6/entry#names_and_taxonomy" } ] }, { "name": "EMP-3", "type": "synonym", "evidence": [ { "id": "NP_001019733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019733" }, { "id": "Q58DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DR6/entry#names_and_taxonomy" } ] }, { "name": "epithelial membrane protein 3", "type": "synonym", "evidence": [ { "id": "NP_001019733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019733" } ] } ], "function": [ { "annotation": "Probably involved in cell proliferation and cell-cell interactions.", "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMP3", "url": "https://www.uniprot.org/uniprotkb/Q58DR6", "locus": { "chromosome": "18", "start_pos": 55042752, "end_pos": 55038414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018013", "url": "https://www.ensembl.org/id/ENSBTAG00000018013" } ] } } ], "crossref": [ { "id": "Q58DR6", "url": "https://alphafold.ebi.ac.uk/entry/Q58DR6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018013", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018013", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535273", "url": "https://www.ncbi.nlm.nih.gov/gene/535273", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535273", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535273", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRFDNFT", "url": "https://omabrowser.org/oma/group/CRFDNFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DR6", "url": "https://www.orthodb.org/?gene=Q58DR6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019733", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DR6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCTWNSDNKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGFCQLCTSVAVFTGALIYAIHAEEILADRPSGGSFGYCFALAWVAFPLALASGIIYIHLRKRE", "length": 163, "header": "sp|Q58DR6-1|EMP3_BOVIN Isoform 1 of Epithelial membrane protein 3 OS=Bos taurus OX=9913 GN=EMP3 PE=2 SV=1 CANONICAL=Q58DR6-1" }, "isoforms": [ { "isoform_ac": "Q58DR6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DR6/entry#Q58DR6-1", "sequence": { "sequence": "MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCTWNSDNKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGFCQLCTSVAVFTGALIYAIHAEEILADRPSGGSFGYCFALAWVAFPLALASGIIYIHLRKRE", "length": 163, "header": "sp|Q58DR6-1|EMP3_BOVIN Isoform 1 of Epithelial membrane protein 3 OS=Bos taurus OX=9913 GN=EMP3 PE=2 SV=1 CANONICAL=Q58DR6-1" }, "locus": { "chromosome": "18", "start_pos": 55042636, "end_pos": 55039740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023976.4", "url": "https://www.ensembl.org/id/ENSBTAT00000023976.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023976.2", "url": "https://www.ensembl.org/id/ENSBTAP00000023976.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 49, "start_aa": "Asn", "end_pos": 49, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn49", "evidence": [ { "id": "Q58DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DR6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 56, "start_aa": "Asn", "end_pos": 56, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn56", "evidence": [ { "id": "Q58DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DR6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535273", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535273", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W1Y8-1", "protein_name": "Epithelial membrane protein 3", "gene_name": "EMP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLLLLVVSALHILILILLFIATLDKSWWTLPGKESLNLWYDCTWNSDNKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILADRPSGGSFGYCFALAWVAFPLALASGIIYIHLRKRE", "length": 163 }, "evidence": [ { "id": "Q58DR6", "url": "https://omabrowser.org/oma/group/Q58DR6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35912-1", "protein_name": "Epithelial membrane protein 3", "gene_name": "Emp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLLLLVVSALHILILVLLFVATLDKSWWTLPDKESLNLWYDCTWNTTTQTWACSNVSENGWLKAVQALMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSAAVFSGALIYAIHTEEILAKHPSGGSFGYCFALAWVAFPLALVSGTVYIHLRKRE", "length": 163 }, "evidence": [ { "id": "Q58DR6", "url": "https://omabrowser.org/oma/group/Q58DR6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P54852-1", "protein_name": "Epithelial membrane protein 3", "gene_name": "EMP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCTWNNDTKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYIHLRKRE", "length": 163 }, "evidence": [ { "id": "Q58DR6", "url": "https://omabrowser.org/oma/group/Q58DR6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ], "pmid": "" }, { "name": "bleb assembly", "id": "GO:0032060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032060", "evidence": [ { "database": "UniProtKB", "id": "Q58DR6", "url": "https://www.uniprot.org/uniprotkb/Q58DR6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DR6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DR6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DR6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 49, 56 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 49, "end_pos": 51 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DS3-1", "uniprot_ac": "Q58DS3", "uniprot_id": "S2535_BOVIN", "mass": { "chemical_mass": 27110.0, "monoisotopic_mass": 27110.0 }, "refseq": { "ac": "NP_001026933", "name": "solute carrier family 25 member 35", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026933" }, "gene_names": [ { "name": "SLC25A35", "type": "recommended", "evidence": [ { "id": "Q58DS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS3" } ] }, { "name": "SLC25A35", "type": "synonym", "evidence": [ { "id": "NP_001026933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026933" } ] } ], "protein_names": [ { "name": "Solute carrier family 25 member 35", "type": "recommended", "evidence": [ { "id": "Q58DS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS3/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 25 member 35", "type": "synonym", "evidence": [ { "id": "NP_001026933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026933" } ] } ], "function": [ { "annotation": "Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "Q58DS3", "url": "https://www.uniprot.org/uniprotkb/Q58DS3#function" }, { "database": "UniProtKB", "id": "Q3KQZ1", "url": "https://www.uniprot.org/uniprotkb/Q3KQZ1#function" }, { "database": "UniProtKB", "id": "A0ABI0NKH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH2#function" }, { "database": "UniProtKB", "id": "ARBA00037259", "url": "https://www.uniprot.org/uniprotkb/ARBA00037259#function" }, { "database": "UniProtKB", "id": "A0ABI0NYN3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYN3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DS3", "url": "https://www.uniprot.org/uniprotkb/Q58DS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC25A35", "url": "https://www.uniprot.org/uniprotkb/Q58DS3", "locus": {} } ], "crossref": [ { "id": "Q58DS3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018808", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018808", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527669", "url": "https://www.ncbi.nlm.nih.gov/gene/527669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527669", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527669", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DS3", "url": "https://www.orthodb.org/?gene=Q58DS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45928", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45928", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45928:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45928:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026933", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "76595", "url": "https://www.rhea-db.org/rhea/76595", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0NKH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKH2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYN3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYN3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DS3", "url": "https://www.uniprot.org/uniprotkb/Q58DS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DS3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFLMSGLAACGACLFTNPLEVVKTRMQLQGELRAPGTYQRHYRNVFHAFITIGKVDGLAALQRGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTLNPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAATEIAVGHQYNHQIFPPQSWKVALAAAMVSGIAVVLAMTPFDVVSTRLYNQPTDAQGKGLMYRGLLDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRMVYYTYTK", "length": 249, "header": "sp|Q58DS3-1|S2535_BOVIN Isoform 1 of Solute carrier family 25 member 35 OS=Bos taurus OX=9913 GN=SLC25A35 PE=2 SV=1 CANONICAL=Q58DS3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NKH2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS3/entry#A0ABI0NKH2-1", "sequence": { "sequence": "MDFLMSGLAACGACLFTNPLEVVKTRMQLQGELRAPGTYQRHYRNVFHAFITIGKVDGLAALQRGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTLNPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAATEIAVGHQYNHQGMFQALTKIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLMTQWEIFPPQSWKVALAAAMVSGIAVVLAMTPFDVVSTRLYNQPTDAQGKNRSPRSSEASCSISASLLGTKDVGIVKGQTGHKLFKVAQAPGRN", "length": 287, "header": "tr|A0ABI0NKH2-1|A0ABI0NKH2_BOVIN Computationally mapped isoform of Solute carrier family 25 member 35 OS=Bos taurus OX=9913 GN=SLC25A35 PE=3 SV=1 CANONICAL=Q58DS3-1" }, "locus": { "chromosome": "19", "start_pos": 27908681, "end_pos": 27905092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152381.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152381.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105238.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105238.1" } ] } }, { "isoform_ac": "A0ABI0NYN3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS3/entry#A0ABI0NYN3-1", "sequence": { "sequence": "MDFLMSGLAACGACLFTNPLEVVKTRMQLQGELRAPGTYQRHYRNVFHAFITIGKVDGLAALQRGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTLNPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAATEIAVGHQYNHQGMFQALTKIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLMTQWEIFPPQSWKVALAAAMVSGIAVVLAMTPFDVVSTRLYNQPTDAQGKGLMYRGLLDALLQTARTEGIFEQKPQVFRSIMQHFSILTGDQRCWDREGSDWSQAVQSRPGSREELTDFPGQEMTYSQGLGVGNR", "length": 328, "header": "tr|A0ABI0NYN3-1|A0ABI0NYN3_BOVIN Computationally mapped isoform of Solute carrier family 25 member 35 OS=Bos taurus OX=9913 GN=SLC25A35 PE=3 SV=1 CANONICAL=Q58DS3-1" }, "locus": { "chromosome": "19", "start_pos": 27908681, "end_pos": 27905033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105426.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105426.1" } ] } }, { "isoform_ac": "Q58DS3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DS3/entry#Q58DS3-1", "sequence": { "sequence": "MDFLMSGLAACGACLFTNPLEVVKTRMQLQGELRAPGTYQRHYRNVFHAFITIGKVDGLAALQRGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTLNPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAATEIAVGHQYNHQIFPPQSWKVALAAAMVSGIAVVLAMTPFDVVSTRLYNQPTDAQGKGLMYRGLLDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRMVYYTYTK", "length": 249, "header": "sp|Q58DS3-1|S2535_BOVIN Isoform 1 of Solute carrier family 25 member 35 OS=Bos taurus OX=9913 GN=SLC25A35 PE=2 SV=1 CANONICAL=Q58DS3-1" }, "locus": { "chromosome": "19", "start_pos": 27908681, "end_pos": 27905732, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151880.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151880.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107587.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107587.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DS3", "url": "https://www.uniprot.org/uniprotkb/Q58DS3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:527669", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527669", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q58DS3", "url": "https://www.uniprot.org/uniprotkb/Q58DS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "76595", "name": "", "equation": "a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "76595", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76595" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DS3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DT8-1", "uniprot_ac": "Q58DT8", "uniprot_id": "WDR55_BOVIN", "mass": { "chemical_mass": 42046.0, "monoisotopic_mass": 42046.0 }, "refseq": { "ac": "NP_001014873", "name": "WD repeat-containing protein 55", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014873" }, "gene_names": [ { "name": "WDR55", "type": "recommended", "evidence": [ { "id": "Q58DT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ] }, { "name": "WDR55", "type": "synonym", "evidence": [ { "id": "NP_001014873", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014873" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 55", "type": "recommended", "evidence": [ { "id": "Q58DT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT8/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 55", "type": "synonym", "evidence": [ { "id": "NP_001014873", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014873" } ] } ], "function": [ { "annotation": "Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR55", "url": "https://www.uniprot.org/uniprotkb/Q58DT8", "locus": { "chromosome": "7", "start_pos": 51800403, "end_pos": 51795499, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015042", "url": "https://www.ensembl.org/id/ENSBTAG00000015042" } ] } } ], "crossref": [ { "id": "Q58DT8", "url": "https://alphafold.ebi.ac.uk/entry/Q58DT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015042", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015042", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508709", "url": "https://www.ncbi.nlm.nih.gov/gene/508709", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508709", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508709", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAIHPTE", "url": "https://omabrowser.org/oma/group/QAIHPTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DT8", "url": "https://www.orthodb.org/?gene=Q58DT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44019:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44019:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014873", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRMCEERAAEDGSDEEDPDATEAPARIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHFLDVELGRLERRISKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPDKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVTLMKYGRKVACGSSEGTIYLFNWDGFGATSDRFALRAESIDCMVPVTESLLCAGSTDGVIRAVNILPNRVVGSVGQHAEEPVENLALSHCGCFLASSGHDQRLKFWDMAQLRALVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREEGEDAKTLEEEESEDDSD", "length": 382, "header": "sp|Q58DT8-1|WDR55_BOVIN Isoform 1 of WD repeat-containing protein 55 OS=Bos taurus OX=9913 GN=WDR55 PE=2 SV=1 CANONICAL=Q58DT8-1" }, "isoforms": [ { "isoform_ac": "Q58DT8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT8/entry#Q58DT8-1", "sequence": { "sequence": "MDRMCEERAAEDGSDEEDPDATEAPARIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHFLDVELGRLERRISKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPDKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVTLMKYGRKVACGSSEGTIYLFNWDGFGATSDRFALRAESIDCMVPVTESLLCAGSTDGVIRAVNILPNRVVGSVGQHAEEPVENLALSHCGCFLASSGHDQRLKFWDMAQLRALVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREEGEDAKTLEEEESEDDSD", "length": 382, "header": "sp|Q58DT8-1|WDR55_BOVIN Isoform 1 of WD repeat-containing protein 55 OS=Bos taurus OX=9913 GN=WDR55 PE=2 SV=1 CANONICAL=Q58DT8-1" }, "locus": { "chromosome": "7", "start_pos": 51800028, "end_pos": 51795601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020021.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020021.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020021.1", "url": "https://www.ensembl.org/id/ENSBTAP00000020021.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "site_lbl": "Ser14" }, { "start_pos": 354, "end_pos": 354, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "site_lbl": "Ser354" }, { "start_pos": 381, "end_pos": 381, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "site_lbl": "Ser381" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508709", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508709", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YCA1-1", "protein_name": "WD repeat-containing protein 55", "gene_name": "WDR55", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPEEEPPAEPQLRDTPDDICLEAAANAIALHPARELLAAGDVDGDVYLYSYCCVQGENRQLWSSGHHLKSCRDVAFSRDGQRLLTVAKDKAVHVLAVEDGRLETRIAKAHGTALNCVLPVDQHLLATGDDNGELKVWDLRKGGAVLEARQHEEYISAMAVDGAGKILLTASGDGTMGVFNIKRRRFELLSEPQSGDLTSVVLLKRGKKVACGSSEGTIYLFNWNGFGATSDRFSLRAESVDCMVPITESIVCTGSLDGVIRAVNILPNRVLGCVGQHLGEPIEQLAVAPGGQLLASCAHDQKVKFWDISSLGSMVVDEYRKKKKRGGPLKALSSKAAGSGEDFFADLREEQEATAEAATGSDSDDSD", "length": 369 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RGE2-1", "protein_name": "WD repeat-containing protein 55", "gene_name": "WDR55", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRTCEEKPTDEVSDEEDPDSTEAPARIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFRYSCQEGDTKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHFLDVEQGRLERRISKAHGAPINSLLLVDENVLATGDDTGGVRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVTLMKCGKKVVCGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCAGSTDGVIRAVHILPNRVVGSVGQHAGEPVEKLALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKAWSPDDFFAGLREEGEDAAAPVQEEEESEDDSD", "length": 384 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O80775-1", "protein_name": "WD repeat-containing protein 55", "gene_name": "WDR55", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEIDLGANAFGIDFHPSTNLVAAGLIDGHLHLYRYDSDSSLVRERKVRAHKESCRAVRFIDDGQRIVTASADCSILATDVETGAQVAHLENAHEDAVNTLINVTETTIASGDDKGCVKIWDTRQRSCSHEFNAHEDYISGMTFASDSMKLVVTSGDGTLSVCNLRTSKVQSQSEFSEDELLSVVIMKNGRKVICGTQNGTLLLYSWGFFKDCSDRFVDLAPNSVDALLKLDEDRLITGCDNGIISLVGILPNRIIQPIGSHDYPIEDLALSHDKKFLGSTAHDSMLKLWNLEEILEGSNVNSGNASGAAEDSDSDNDGMDLDNDPSKSSKGSKRKTKSKANTLNATNNFFADL", "length": 353 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q06214-1", "protein_name": "WD repeat-containing protein JIP5", "gene_name": "JIP5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKSKKKTDVVDSTNLPILELLSLKAPIFQSLLHPELPIIITGFGTGHIVCHRYDPAKLQSHLDRRRRIDTATTGKDAKKGVCPWIRLDIDLETGDLKFVDIEEQQQQKQTGKDEDLGVKTLWKTKRHKGSVRAMCFDSKGDNIFSVGSDNVLKKANTMTGKVVKKVNLSSLFNSEEKKNDKFTKLCASQTHPFILIGDESGNIHVINSENLALSNSIRSIHFGDSINDIFHFDKRSAYKFISLGQTTLAYFDVRDKDAKPNVAGNEDGKILISDDQEDEVLCGCFVDPEVADTLLCGMGEGIVTVWKPNKNDLEDQMSRIKISKDESIDCIVPTLQDDNCVWCGCSNGNIYKVNAKLGKVVEIRNHSELDEVSFVDLDFEYRVVSGGLENIKIWELSSDDVEENASVESDSDEPLSHSDEDLSDDTSSDDETTLVGLSKEELLDELDKDLKEDHQEEKESNSKSVKKRKIMKENNKKKDLYEHGIKKFDDL", "length": 492 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54SA5-1", "protein_name": "WD repeat-containing protein 55 homolog", "gene_name": "wdr55", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDTSSEGDHELAPNDISFNTIPFSLNFHPTEDLLVVSDAEGRLKLFKYSLDENEVKLSLRPHQSGCRQANFSSDGKYIFTASSDCSMKVIDINTGSILYTREEAHDYPINCLVSKEFMVFTGDDEGTIKVWDMRQQNIVCEFQEHGDFISDITTIDDRHIAATSGDGGVSIYNFVRKSMDDISEKSDNELLSCLSLDNGQKLVCGSQDGSILIYDRNNLENVKKFAGHPQSVDALVKVNNNTFFSGSSDGIIRFIGLRPKKLLGVVGEHSTFPIERMAISRDNRYLGSISHDFSLKFWNVASFYEEDESEDADSANANANEIENDDDDDDDDDEIEDIENATKVDDDSGSEMGDDDDDDDDEEQEEEEESSSDEDIKRKKPQQNPIKAQQIEKQKQKQNQKRSFFKDL", "length": 408 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CX97-1", "protein_name": "WD repeat-containing protein 55", "gene_name": "Wdr55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPTCEESPAEDSNNEEEDLDSTKAAPRIRDTPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCIVPVTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGEPVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREDEEDAKAPEEVVRESDDDDDDSD", "length": 388 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6Y2-1", "protein_name": "WD repeat-containing protein 55", "gene_name": "WDR55", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFAGLREEGEDSMAQEEKEETGDDSD", "length": 383 }, "evidence": [ { "id": "Q58DT8", "url": "https://omabrowser.org/oma/group/Q58DT8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q58DT8", "url": "https://www.uniprot.org/uniprotkb/Q58DT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DT8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DT8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DT8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 354, 381 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DU7-1", "uniprot_ac": "Q58DU7", "uniprot_id": "SH3L1_BOVIN", "mass": { "chemical_mass": 12776.0, "monoisotopic_mass": 12776.0 }, "refseq": { "ac": "NP_001030517", "name": "adapter SH3BGRL", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" }, "gene_names": [ { "name": "SH3BGRL", "type": "recommended", "evidence": [ { "id": "Q58DU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ] }, { "name": "SH3BGRL", "type": "synonym", "evidence": [ { "id": "NP_001030517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" } ] } ], "protein_names": [ { "name": "Adapter SH3BGRL", "type": "recommended", "evidence": [ { "id": "Q58DU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU7/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain binding glutamic acid-rich protein like", "type": "synonym", "evidence": [ { "id": "NP_001030517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" } ] }, { "name": "SH3 domain-binding glutamic acid-rich-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" }, { "id": "Q58DU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU7/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain-binding glutamic acid-rich-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" } ] }, { "name": "adapter SH3BGRL", "type": "synonym", "evidence": [ { "id": "NP_001030517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517" } ] } ], "function": [ { "annotation": "Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7#function" }, { "database": "UniProtKB", "id": "O75368", "url": "https://www.uniprot.org/uniprotkb/O75368#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH3BGRL", "url": "https://www.uniprot.org/uniprotkb/Q58DU7", "locus": {} } ], "crossref": [ { "id": "Q58DU7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010587", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010587", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614007", "url": "https://www.ncbi.nlm.nih.gov/gene/614007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEKEFMQ", "url": "https://omabrowser.org/oma/group/NEKEFMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DU7", "url": "https://www.orthodb.org/?gene=Q58DU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12232:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12232:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030517", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DU7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVIRVYIASSSGSMAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQAKQQA", "length": 114, "header": "sp|Q58DU7-1|SH3L1_BOVIN Isoform 1 of Adapter SH3BGRL OS=Bos taurus OX=9913 GN=SH3BGRL PE=3 SV=1 CANONICAL=Q58DU7-1" }, "isoforms": [ { "isoform_ac": "Q58DU7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU7/entry#Q58DU7-1", "sequence": { "sequence": "MVIRVYIASSSGSMAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQAKQQA", "length": 114, "header": "sp|Q58DU7-1|SH3L1_BOVIN Isoform 1 of Adapter SH3BGRL OS=Bos taurus OX=9913 GN=SH3BGRL PE=3 SV=1 CANONICAL=Q58DU7-1" }, "locus": { "chromosome": "X", "start_pos": 71330029, "end_pos": 71203389, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153060.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153060.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106055.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106055.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614007", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S1R4-1", "protein_name": "SH3 domain-binding glutamic acid-rich-like protein", "gene_name": "SH3BGRL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENRRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLKAPPGSKEAEAQAKKQV", "length": 114 }, "evidence": [ { "id": "Q58DU7", "url": "https://omabrowser.org/oma/group/Q58DU7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I1P5-1", "protein_name": "SH3 domain-binding glutamic acid-rich-like protein", "gene_name": "Sh3bgrl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPEDSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQAKQQA", "length": 114 }, "evidence": [ { "id": "Q58DU7", "url": "https://omabrowser.org/oma/group/Q58DU7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75368-1", "protein_name": "Adapter SH3BGRL", "gene_name": "SH3BGRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA", "length": 114 }, "evidence": [ { "id": "Q58DU7", "url": "https://omabrowser.org/oma/group/Q58DU7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJU8-1", "protein_name": "Adapter Sh3bgrl", "gene_name": "Sh3bgrl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVIRVYIASSSGSTAIKKKQQDVLCFLEANKIGFEEKDIAANEENRKWMRENVPEDSRPSTGYPLPPQIFNECQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQANQQA", "length": 114 }, "evidence": [ { "id": "Q58DU7", "url": "https://omabrowser.org/oma/group/Q58DU7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" }, { "name": "protein-RNA adaptor activity", "id": "GO:0140517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140517", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" }, { "name": "positive regulation of cytoplasmic translational initiation", "id": "GO:1904690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904690", "evidence": [ { "database": "UniProtKB", "id": "Q58DU7", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DU7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 114, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DU7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DU7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU7" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "SH3-binding", "eco_id": "ECO_0000255", "start_pos": 61, "end_pos": 67, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DV7-1", "uniprot_ac": "Q58DV7", "uniprot_id": "HNMT_BOVIN", "mass": { "chemical_mass": 33646.0, "monoisotopic_mass": 33646.0 }, "refseq": { "ac": "NP_001030511", "name": "histamine N-methyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030511" }, "gene_names": [ { "name": "HNMT", "type": "recommended", "evidence": [ { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ] }, { "name": "HNMT", "type": "synonym", "evidence": [ { "id": "NP_001030511", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030511" } ] } ], "protein_names": [ { "name": "Histamine N-methyltransferase", "type": "recommended", "evidence": [ { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.8", "type": "synonym", "evidence": [ { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7/entry#names_and_taxonomy" } ] }, { "name": "HMT", "type": "synonym", "evidence": [ { "id": "NP_001030511", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030511" }, { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7/entry#names_and_taxonomy" } ] }, { "name": "histamine N-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001030511", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030511" } ] } ], "function": [ { "annotation": "Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7#function" }, { "database": "UniProtKB", "id": "P50135", "url": "https://www.uniprot.org/uniprotkb/P50135#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNMT", "url": "https://www.uniprot.org/uniprotkb/Q58DV7", "locus": { "chromosome": "2", "start_pos": 59138783, "end_pos": 59179844, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014432", "url": "https://www.ensembl.org/id/ENSBTAG00000014432" } ] } } ], "crossref": [ { "id": "Q58DV7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014432", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014432", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613413", "url": "https://www.ncbi.nlm.nih.gov/gene/613413", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613413", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613413", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNIKFAW", "url": "https://omabrowser.org/oma/group/KNIKFAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DV7", "url": "https://www.orthodb.org/?gene=Q58DV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF13489", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13489", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030511", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19301", "url": "https://www.rhea-db.org/rhea/19301", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DV7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSMRSLFTDHSRYVESFRRFLSNSTEHQCMQEFMDKKLPGIIARIGDIKSEIKILSIGGGAGEIDLQILSKVQAQYPGVHIINEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETSSEYQNRMMEKKELQRWDFIHMIQMLYYVKDIPATLKFFHSLLATNAKILIIIVSGASSWQKLWEKYGSRLPRNDLCQYVTSSDLTQMLDKLGIKYEYYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNTTAPPDLKAEIMKDLQKPEFSIKKEGKVLFNNSLSFIVVEA", "length": 292, "header": "sp|Q58DV7-1|HNMT_BOVIN Isoform 1 of Histamine N-methyltransferase OS=Bos taurus OX=9913 GN=HNMT PE=2 SV=1 CANONICAL=Q58DV7-1" }, "isoforms": [ { "isoform_ac": "Q58DV7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DV7/entry#Q58DV7-1", "sequence": { "sequence": "MASSMRSLFTDHSRYVESFRRFLSNSTEHQCMQEFMDKKLPGIIARIGDIKSEIKILSIGGGAGEIDLQILSKVQAQYPGVHIINEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETSSEYQNRMMEKKELQRWDFIHMIQMLYYVKDIPATLKFFHSLLATNAKILIIIVSGASSWQKLWEKYGSRLPRNDLCQYVTSSDLTQMLDKLGIKYEYYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNTTAPPDLKAEIMKDLQKPEFSIKKEGKVLFNNSLSFIVVEA", "length": 292, "header": "sp|Q58DV7-1|HNMT_BOVIN Isoform 1 of Histamine N-methyltransferase OS=Bos taurus OX=9913 GN=HNMT PE=2 SV=1 CANONICAL=Q58DV7-1" }, "locus": { "chromosome": "2", "start_pos": 59179839, "end_pos": 59139780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019196.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019196.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019196.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019196.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:613413", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613413", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AA45-1", "protein_name": "Histamine N-methyltransferase", "gene_name": "HNMT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASSMRSLFSDHGRYVESFRRFLNNSTEHQCMQEFMDKQLPGIIASIGDTNSEIKILSIGGGAGEIDLQILSKVRAQYPGIRINNEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETSSEYQNRMMQKKELQKWDFIHMIQMLYYVEDIPATLKFFHSLLASHAKILIILVSGASGWDKLWKKYGSRLPRDDLCQYVTSSDLTQMLDKLGIKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCHFNATAPPDLKEEIMKDLQEPEFSVKKGGKVLFNNSLSFIVVWG", "length": 292 }, "evidence": [ { "id": "Q58DV7", "url": "https://omabrowser.org/oma/group/Q58DV7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P50135-1", "protein_name": "Histamine N-methyltransferase", "gene_name": "HNMT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA", "length": 292 }, "evidence": [ { "id": "Q58DV7", "url": "https://omabrowser.org/oma/group/Q58DV7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q01984-1", "protein_name": "Histamine N-methyltransferase", "gene_name": "Hnmt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV", "length": 295 }, "evidence": [ { "id": "Q58DV7", "url": "https://omabrowser.org/oma/group/Q58DV7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91VF2-1", "protein_name": "Histamine N-methyltransferase", "gene_name": "Hnmt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASCMRSLFSDQGRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGEAKAEIKILSVGGGAGEVDLQILSKVQAQYPGICINNEVVEPSAEQIVKYKELVAKTSNMENIKFSWHKETSSEYQKRMLEEEEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAASAKILIILVSGTSGWEKLWKKYGSRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLVSTMDITDCFIDGNENGDLLWDFLTETCNFSKTAPLDLKAEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV", "length": 295 }, "evidence": [ { "id": "Q58DV7", "url": "https://omabrowser.org/oma/group/Q58DV7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "pmid": "" }, { "name": "histamine catabolic process", "id": "GO:0001695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001695", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histamine N-methyltransferase activity", "id": "GO:0046539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046539", "evidence": [ { "database": "UniProtKB", "id": "Q58DV7", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19301", "name": "", "equation": "histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DV7-1" ], "evidence": [ { "id": "19301", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19301" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q58DV7", "gene_name": "HNMT", "activity": [ { "ec_number": "2.1.1.8", "activity": "histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ] }, { "ec_number": "2.1.1.8", "activity": "", "evidence": [ { "id": "Q58DV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DV7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DV7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DV7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DV7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.8", "ec_name": "histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.8" }, { "id": "2.1.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.8" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 25, "end_pos": 27 }, { "start_pos": 282, "end_pos": 284 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DW3-1", "uniprot_ac": "Q58DW3", "uniprot_id": "RL29_BOVIN", "mass": { "chemical_mass": 16772.0, "monoisotopic_mass": 16772.0 }, "refseq": { "ac": "NP_001014862", "name": "large ribosomal subunit protein eL29", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014862" }, "gene_names": [ { "name": "RPL29", "type": "recommended", "evidence": [ { "id": "Q58DW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ] }, { "name": "RPL29", "type": "synonym", "evidence": [ { "id": "NP_001014862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014862" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL29", "type": "recommended", "evidence": [ { "id": "Q58DW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW3/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L29", "type": "synonym", "evidence": [ { "id": "NP_001014862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014862" }, { "id": "Q58DW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW3/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL29", "type": "synonym", "evidence": [ { "id": "NP_001014862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014862" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3#function" }, { "database": "UniProtKB", "id": "P47914", "url": "https://www.uniprot.org/uniprotkb/P47914#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL29", "url": "https://www.uniprot.org/uniprotkb/Q58DW3", "locus": { "chromosome": "22", "start_pos": 48947321, "end_pos": 48945144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018628", "url": "https://www.ensembl.org/id/ENSBTAG00000018628" } ] } } ], "crossref": [ { "id": "Q58DW3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018628", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018628", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507270", "url": "https://www.ncbi.nlm.nih.gov/gene/507270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507270", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507270", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LISGHHY", "url": "https://omabrowser.org/oma/group/LISGHHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DW3", "url": "https://www.orthodb.org/?gene=Q58DW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12884:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12884:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014862", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DW3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAVKALVKPKEIKPKMPTGGSRKLSRLAYIAHPKLGKRARARIAKGLRLCRPKSQAKASTKAKPPAAAAPAAKGAQAPTKAPE", "length": 152, "header": "sp|Q58DW3-1|RL29_BOVIN Isoform 1 of Large ribosomal subunit protein eL29 OS=Bos taurus OX=9913 GN=RPL29 PE=2 SV=3 CANONICAL=Q58DW3-1" }, "isoforms": [ { "isoform_ac": "Q58DW3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW3/entry#Q58DW3-1", "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAVKALVKPKEIKPKMPTGGSRKLSRLAYIAHPKLGKRARARIAKGLRLCRPKSQAKASTKAKPPAAAAPAAKGAQAPTKAPE", "length": 152, "header": "sp|Q58DW3-1|RL29_BOVIN Isoform 1 of Large ribosomal subunit protein eL29 OS=Bos taurus OX=9913 GN=RPL29 PE=2 SV=3 CANONICAL=Q58DW3-1" }, "locus": { "chromosome": "22", "start_pos": 48947206, "end_pos": 48945582, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024788.4", "url": "https://www.ensembl.org/id/ENSBTAT00000024788.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024788.2", "url": "https://www.ensembl.org/id/ENSBTAP00000024788.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "site_lbl": "Ser31" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507270", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507270", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZTF4-1", "protein_name": "60S ribosomal protein L29", "gene_name": "LOC120098629", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYKSLKGVDAKFLRNMRFAKKHNKKGLKKMQANNAKAVSARAEAIKALVKPQAVKPKMPKGSSRKLSRLAFIAHPKLGKKIRNYMAKGRRLCQPKPKVQTKAEAKAPAKAQAKAPAQAPKGAQAPVKAP", "length": 156 }, "evidence": [ { "id": "Q58DW3", "url": "https://omabrowser.org/oma/group/Q58DW3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47914-1", "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "RPL29", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE", "length": 159 }, "evidence": [ { "id": "Q58DW3", "url": "https://omabrowser.org/oma/group/Q58DW3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q95281-1", "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "RPL29", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPNIPKGGSRKLSRLAYIAHPKLGKRARARIAKGLRFCRPKSQAKAQSKAKATAGGTAAAPVPPASAPKGAQAPTKAPQ", "length": 160 }, "evidence": [ { "id": "Q58DW3", "url": "https://omabrowser.org/oma/group/Q58DW3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "W4VSN7-1", "protein_name": "60S ribosomal protein L29", "gene_name": "Rpl27rt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLEKMQASNAKAVSVHAEAIKALVKPQAIKPKMPKGPKLKRLAFIAHPKLGKRIRSYMAKGQRLCQPKPKVQTKAGAKAPAKAQASTPAQAPKGAQAPKGAQAPVKAP", "length": 160 }, "evidence": [ { "id": "Q58DW3", "url": "https://omabrowser.org/oma/group/Q58DW3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q58DW3", "url": "https://www.uniprot.org/uniprotkb/Q58DW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DW3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DW3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DW3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 31 ], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q59A28-1", "uniprot_ac": "Q59A28", "uniprot_id": "QORL1_BOVIN", "mass": { "chemical_mass": 38812.0, "monoisotopic_mass": 38812.0 }, "refseq": { "ac": "NP_001030209", "name": "ferry endosomal RAB5 effector complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" }, "gene_names": [ { "name": "CRYZL1", "type": "recommended", "evidence": [ { "id": "Q59A28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59A28" } ] }, { "name": "CRYZL1", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] } ], "protein_names": [ { "name": "Ferry endosomal RAB5 effector complex subunit 4", "type": "recommended", "evidence": [ { "id": "Q59A28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59A28/entry#names_and_taxonomy" } ] }, { "name": "Crystallin zeta like 1", "type": "synonym", "evidence": [ { "id": "Q59A28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59A28/entry#names_and_taxonomy" } ] }, { "name": "QOH-1", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] }, { "name": "crystallin, zeta (quinone reductase)-like 1", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] }, { "name": "ferry endosomal RAB5 effector complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] }, { "name": "quinone oxidoreductase homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] }, { "name": "quinone oxidoreductase-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] }, { "name": "zeta-crystallin homolog", "type": "synonym", "evidence": [ { "id": "NP_001030209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209" } ] } ], "function": [ { "annotation": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction.", "evidence": [ { "database": "UniProtKB", "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28#function" }, { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprotkb/O95825#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYZL1", "url": "https://www.uniprot.org/uniprotkb/Q59A28", "locus": { "chromosome": "1", "start_pos": 1943741, "end_pos": 1909586, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008490", "url": "https://www.ensembl.org/id/ENSBTAG00000008490" } ] } } ], "crossref": [ { "id": "Q59A28", "url": "https://alphafold.ebi.ac.uk/entry/Q59A28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008490", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008490", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506426", "url": "https://www.ncbi.nlm.nih.gov/gene/506426", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506426", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506426", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AHHWGAK", "url": "https://omabrowser.org/oma/group/AHHWGAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q59A28", "url": "https://www.orthodb.org/?gene=Q59A28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44461:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44461:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q59A28-1", "url": "https://www.uniprot.org/uniprotkb/Q59A28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGLYFQQSSTNEEITFVFQERENLPVTEDNYVKLQVKACALSQINTKLLAEMKMEKEFFPVGREVAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEAVRVHEHYLVHKPEKVTWTEAAGTIRDGLRVYTALHYLSHLSPGKSVLIMDGASALGTIAIQLAHHRGAKVISTACSLEDKQFLERFRPPIARVIDVSNGKAHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAEKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGAAVAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVTMEVVQKNQGRKKQVVQF", "length": 349, "header": "sp|Q59A28-1|QORL1_BOVIN Isoform 1 of Ferry endosomal RAB5 effector complex subunit 4 OS=Bos taurus OX=9913 GN=CRYZL1 PE=2 SV=1 CANONICAL=Q59A28-1" }, "isoforms": [ { "isoform_ac": "Q59A28-1", "url": "https://www.uniprot.org/uniprotkb/Q59A28/entry#Q59A28-1", "sequence": { "sequence": "MKGLYFQQSSTNEEITFVFQERENLPVTEDNYVKLQVKACALSQINTKLLAEMKMEKEFFPVGREVAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEAVRVHEHYLVHKPEKVTWTEAAGTIRDGLRVYTALHYLSHLSPGKSVLIMDGASALGTIAIQLAHHRGAKVISTACSLEDKQFLERFRPPIARVIDVSNGKAHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAEKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGAAVAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVTMEVVQKNQGRKKQVVQF", "length": 349, "header": "sp|Q59A28-1|QORL1_BOVIN Isoform 1 of Ferry endosomal RAB5 effector complex subunit 4 OS=Bos taurus OX=9913 GN=CRYZL1 PE=2 SV=1 CANONICAL=Q59A28-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2.", "journal": "Gene", "date": "2005", "authors": "W\u00f6hlke Anne, Dr\u00f6gem\u00fcller Cord, Kuiper Heidi, Leeb Tosso, Distl Ottmar", "evidence": [ { "database": "UniProtKB", "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28" } ], "reference": [ { "type": "PubMed", "id": "15777723", "url": "https://glygen.org/publication/PubMed/15777723" } ] } ], "pathway": [ { "id": "bta:506426", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506426", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QC54-1", "protein_name": "Quinone oxidoreductase-like protein 1 isoform X4", "gene_name": "Cryzl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKGLYFQQSSTNEEITFLFQERESLPVTEDNFVKLQVKACALSQINTKLLAEMKMEKDFFPVGREVAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVIQVHEHYLVHKPEKVSWTAAAGAIRDGVRACTALYYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQHLERIRPSIARVIDISSGKVHVAESCLEETGGLGVDIVIDAGVRLYSKDDEPAVKSQLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATVAFLNDEVWNLSNAQQGKYLCILRDVMEKLSAGIFRPLLDEPIPLYEAKASMEVVQKNQERKKQVVQF", "length": 348 }, "evidence": [ { "id": "Q59A28", "url": "https://omabrowser.org/oma/group/Q59A28/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95825-1", "protein_name": "Ferry endosomal RAB5 effector complex subunit 4", "gene_name": "CRYZL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF", "length": 349 }, "evidence": [ { "id": "Q59A28", "url": "https://omabrowser.org/oma/group/Q59A28/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q921W4-1", "protein_name": "Ferry endosomal RAB5 effector complex subunit 4", "gene_name": "Cryzl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGLYFQQSSTNEEVTFVFQEKENVPVTEDNFVRVQVKACALSHINTKLLAEMKMEKDFFPVGREVSGIVLEVGRKVTFFQPDDEVVGILPLDSEDPGLCEVIRVHEHYLVHKPEKVSWTEAAGVIRDGVRACTALYYLSQLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTAHSLEDKQHLERLRPSIARVIDVSNGKVHVAESCLEETGGLGVDIVIDAGVRLYSKDDEPAVKLHLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATVAFLNDEVWNLSNAQQGKYLCILKDVMEKLSAGVFRPLLDEPIPLYEAKVSMEVVQKNQERKKQVVQF", "length": 348 }, "evidence": [ { "id": "Q59A28", "url": "https://omabrowser.org/oma/group/Q59A28/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q59A28", "url": "https://www.uniprot.org/uniprotkb/Q59A28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q59A28-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q59A28-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q59A28" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIN4-1", "uniprot_ac": "Q5BIN4", "uniprot_id": "TIM22_BOVIN", "mass": { "chemical_mass": 20156.0, "monoisotopic_mass": 20156.0 }, "refseq": { "ac": "NP_001029670", "name": "mitochondrial import inner membrane translocase subunit Tim22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029670" }, "gene_names": [ { "name": "TIMM22", "type": "recommended", "evidence": [ { "id": "Q5BIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ] }, { "name": "TIM22", "type": "synonym", "evidence": [ { "id": "Q5BIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ] }, { "name": "TIMM22", "type": "synonym", "evidence": [ { "id": "NP_001029670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029670" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit Tim22", "type": "recommended", "evidence": [ { "id": "Q5BIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim22", "type": "synonym", "evidence": [ { "id": "NP_001029670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029670" } ] }, { "name": "translocase of inner mitochondrial membrane 22 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029670", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029670" } ] } ], "function": [ { "annotation": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4#function" }, { "database": "UniProtKB", "id": "Q12328", "url": "https://www.uniprot.org/uniprotkb/Q12328#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM22", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4", "locus": { "chromosome": "19", "start_pos": 21863743, "end_pos": 21870400, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008423", "url": "https://www.ensembl.org/id/ENSBTAG00000008423" } ] } } ], "crossref": [ { "id": "Q5BIN4", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008423", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008423", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515555", "url": "https://www.ncbi.nlm.nih.gov/gene/515555", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515555", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515555", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VNPNMAD", "url": "https://omabrowser.org/oma/group/VNPNMAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIN4", "url": "https://www.orthodb.org/?gene=Q5BIN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14110", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14110", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14110:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14110:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029670", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIN4-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATAPKAGGSAPEAAASAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGLKAGVIGCGGFAAFSAAIDYYLR", "length": 194, "header": "sp|Q5BIN4-1|TIM22_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim22 OS=Bos taurus OX=9913 GN=TIMM22 PE=2 SV=1 CANONICAL=Q5BIN4-1" }, "isoforms": [ { "isoform_ac": "Q5BIN4-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4/entry#Q5BIN4-1", "sequence": { "sequence": "MAATAPKAGGSAPEAAASAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGLKAGVIGCGGFAAFSAAIDYYLR", "length": 194, "header": "sp|Q5BIN4-1|TIM22_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit Tim22 OS=Bos taurus OX=9913 GN=TIMM22 PE=2 SV=1 CANONICAL=Q5BIN4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515555", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515555", "resource": "KEGG Pathway" }, { "id": "R-BTA-1268020", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0P855-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22", "gene_name": "TIMM22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAATAPSAGVSAPEAAASTEAPLQYSLLLQHLVGDKRQPRVLEPGTLGGIPSPAKSEEQKMIERAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGLKAGVIGCGGFAAFSAAIDYYLR", "length": 194 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A2RVP7-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22-1", "gene_name": "TIM22-1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADSSAAEPTTGASSPPVASDENSTQIQPIRMPTIEEIRAQEVWNNCAVRAVTSGVMGGGLGLMMGLFLGALDNPITHDTMTARQQFVFTAKQMGQRSWNSCKTFAVMGLVFSAAECIVEKARAKHDTVNTAIAGCVTGGSMSARGGPKAACIGCAGFATFSVLIEKFFDRHT", "length": 173 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "E7FA60-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22", "gene_name": "timm22", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPAKSTDASLSVTAGHSANVSSAENVSLQYSLILDHLIGDKRQIKDLNPTVMGALPSPQKTDEQKMIERGMESCAFKSLIACVGGFVLGGAFGVFTAGIDANVGLDPKDPLRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESHRGKSDWKNAVYSGCITGGAIGFRAGLKAGVLGCGGFAAFSAAIEYYLR", "length": 201 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HTH2-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22", "gene_name": "Timm22", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAATAPSAGASAAESATSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPSKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR", "length": 194 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12328-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22", "gene_name": "TIM22", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVYTGFGLEQISPAQKKPYNELTPEEQGERGAEMIMNFMTSCPGKSVVSGVTGFALGGVLGLFMASMAYDTPLHTPTPANTAATATAGNIGVGGISRTVQQISDLPFRQQMKLQFTDMGKKSYSSAKNFGYIGMIYAGVECVIESLRAKNDIYNGVTAGFFTGAGLAYKAGPQAALMGGAGFAAFSAAIDLYMKSEDGRPPQNDFKE", "length": 207 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54QM0-1", "protein_name": "Mitochondrial import inner membrane translocase subunit tim22", "gene_name": "timm22", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MANISDEELKKILSDNAHKFMFAENGVRDFLPNIKNIAPYNEMQYNLMDNCIVHGVRGMVMGGAFGFLFGALFTPNSGFTPEPTTPTPLYRQVIDGFKEQGRSGLRSAKSLSIITLVYTGTECAIEKARGRTDKLNPIYAGCTTGAVFAGRAGPMAAVGGCVGFAVFGMIMDHFMVFFF", "length": 179 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8IN78-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Tim22", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVLPNAGNNESSVTAPKMFGDPDLDRMAMEYVGNMQRYRENIIIPKSNGPVKIKTNEEKFIETAVESCGFKCTMACVMGYGLGAALGLFSASVNPNMADPFANEKKQTAREVFREMRSTTHSYAKNFALIGCVFSAVECTIESHRGVTDWKNGTYAGGITGGLIGLRAGVKAGIIGGLGFAAFSTAIDYYMYSR", "length": 195 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9CQ85-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Timm22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATAPKAGGSAPEAAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR", "length": 194 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JKW1-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Timm22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAKAGASAPEAAGSAEAPLQYSLLLQHLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR", "length": 192 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y584-1", "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "TIMM22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAPNAGGSAPETAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCGGFAAFSAAIDYYLR", "length": 194 }, "evidence": [ { "id": "Q5BIN4", "url": "https://omabrowser.org/oma/group/Q5BIN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TIM22 mitochondrial import inner membrane insertion complex", "id": "GO:0042721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042721", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "pmid": "" }, { "name": "mitochondrion targeting sequence binding", "id": "GO:0030943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030943", "evidence": [ { "database": "UniProtKB", "id": "Q5BIN4", "url": "https://www.uniprot.org/uniprotkb/Q5BIN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIP2-1", "uniprot_ac": "Q5BIP2", "uniprot_id": "PGFRL_BOVIN", "mass": { "chemical_mass": 41820.0, "monoisotopic_mass": 41820.0 }, "refseq": { "ac": "NP_001030378", "name": "platelet-derived growth factor receptor-like protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378" }, "gene_names": [ { "name": "PDGFRL", "type": "recommended", "evidence": [ { "id": "Q5BIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2" } ] }, { "name": "PDGFRL", "type": "synonym", "evidence": [ { "id": "NP_001030378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378" } ] } ], "protein_names": [ { "name": "Platelet-derived growth factor receptor-like protein", "type": "recommended", "evidence": [ { "id": "Q5BIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2/entry#names_and_taxonomy" } ] }, { "name": "PDGFR-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378" }, { "id": "Q5BIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2/entry#names_and_taxonomy" } ] }, { "name": "platelet-derived growth factor receptor-like protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001030378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378" } ] }, { "name": "platelet-derived growth factor receptor-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIP2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDGFRL", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2", "locus": { "chromosome": "27", "start_pos": 19631336, "end_pos": 19709829, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001966", "url": "https://www.ensembl.org/id/ENSBTAG00000001966" } ] } } ], "crossref": [ { "id": "Q5BIP2", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "515017", "url": "https://www.ncbi.nlm.nih.gov/gene/515017", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515017", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515017", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5BIP2", "url": "https://www.orthodb.org/?gene=Q5BIP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15360:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15360:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030378", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5BIP2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP2-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIWLLLGLLLMHEALEDVTGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTQSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKDERPVTIQDSWRLIHRGLGHTTRISQSVLSIEDFETIDAGYYICTAQNLQGQTTVATTVESS", "length": 375, "header": "sp|Q5BIP2-1|PGFRL_BOVIN Isoform 1 of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=2 SV=1 CANONICAL=Q5BIP2-1" }, "isoforms": [ { "isoform_ac": "Q5BIP2-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2/entry#Q5BIP2-1", "sequence": { "sequence": "MKIWLLLGLLLMHEALEDVTGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTQSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKDERPVTIQDSWRLIHRGLGHTTRISQSVLSIEDFETIDAGYYICTAQNLQGQTTVATTVESS", "length": 375, "header": "sp|Q5BIP2-1|PGFRL_BOVIN Isoform 1 of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=2 SV=1 CANONICAL=Q5BIP2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 132, "start_aa": "Asn", "end_pos": 132, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn132", "evidence": [ { "id": "Q5BIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 219, "start_aa": "Asn", "end_pos": 219, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn219", "evidence": [ { "id": "Q5BIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515017", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515017", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "platelet-derived growth factor receptor activity", "id": "GO:0005017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005017", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIP2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 375, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIP2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIP2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 132, 219 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIP5-1", "uniprot_ac": "Q5BIP5", "uniprot_id": "GFOD2_BOVIN", "mass": { "chemical_mass": 42145.0, "monoisotopic_mass": 42145.0 }, "refseq": { "ac": "NP_001014863", "name": "glucose-fructose oxidoreductase domain-containing protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014863" }, "gene_names": [ { "name": "GFOD2", "type": "recommended", "evidence": [ { "id": "Q5BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ] }, { "name": "GFOD2", "type": "synonym", "evidence": [ { "id": "NP_001014863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014863" } ] } ], "protein_names": [ { "name": "Glucose-fructose oxidoreductase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q5BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5/entry#names_and_taxonomy" } ] }, { "name": "1.-.-.-", "type": "synonym", "evidence": [ { "id": "Q5BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5/entry#names_and_taxonomy" } ] }, { "name": "glucose-fructose oxidoreductase domain-containing protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001014863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014863" } ] }, { "name": "glucose-fructose oxidoreductase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001014863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014863" } ] } ], "function": [ { "annotation": "Promotes matrix assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GFOD2", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5", "locus": { "chromosome": "18", "start_pos": 35224968, "end_pos": 35264273, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018908", "url": "https://www.ensembl.org/id/ENSBTAG00000018908" } ] } } ], "crossref": [ { "id": "Q5BIP5", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018908", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018908", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507361", "url": "https://www.ncbi.nlm.nih.gov/gene/507361", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507361", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507361", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVGEIQV", "url": "https://omabrowser.org/oma/group/YVGEIQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIP5", "url": "https://www.orthodb.org/?gene=Q5BIP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43818:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43818:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22725", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22725", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014863", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP5-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMLPGVGVFGTGSSARVLVPLLRAEGFTVQALWGKTEEEAKQLAEEMNIAFYTSRTDDVLLHQDVDLVCINMPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARVYSGSLLSPNYGWICDELMGGGGLHTMGTYIVDLLTHLTGQRAEKVHGLLKTFVRQNAAIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAPQEELLLRDSLAVGAGLPEQGAQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDHTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWEAVEVLAEEPDANQNLCEALQRNNL", "length": 385, "header": "sp|Q5BIP5-1|GFOD2_BOVIN Isoform 1 of Glucose-fructose oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=GFOD2 PE=2 SV=1 CANONICAL=Q5BIP5-1" }, "isoforms": [ { "isoform_ac": "Q5BIP5-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5/entry#Q5BIP5-1", "sequence": { "sequence": "MKMLPGVGVFGTGSSARVLVPLLRAEGFTVQALWGKTEEEAKQLAEEMNIAFYTSRTDDVLLHQDVDLVCINMPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARVYSGSLLSPNYGWICDELMGGGGLHTMGTYIVDLLTHLTGQRAEKVHGLLKTFVRQNAAIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAPQEELLLRDSLAVGAGLPEQGAQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDHTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWEAVEVLAEEPDANQNLCEALQRNNL", "length": 385, "header": "sp|Q5BIP5-1|GFOD2_BOVIN Isoform 1 of Glucose-fructose oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=GFOD2 PE=2 SV=1 CANONICAL=Q5BIP5-1" }, "locus": { "chromosome": "18", "start_pos": 35235995, "end_pos": 35225630, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025164.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025164.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025164.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025164.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507361", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507361", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WBV3-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "Gfod2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRCPPATPPLRTRDPCSLETRRRVPGIGALDSGARARIRSILPQGRRTASETRPDPWFRVRLWAGNAIMPGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSSSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVHGLLKTFVRQNATIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWETVELLTEEPDANQNLSETLQRNNL", "length": 369 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1R1S8-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "gfod2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLPGVGVFGTGQTVRALVPLLQKEGFPVQAVWGRTQEEAESLASELDIPFSTSQTDDVLLHPEVHLVCILTPPPHTRQIAVKALGIGKNVISEQAATLTDACKMVTAARYYPQLMSIMGNSLRFLPAFVHMKRLLGEGYCGSLQVCEARVYGGSLLSQSYGWAWEELMGGGGLHTVGSCIIDLLSHLTGCRAVRVHGMLRTFVRQGGPAGGIRSVTADDYACFQLLMSGGAVCSVTLNFNLPGTDVHEIMLVGSSGRLVARGTELFGQRINMQAEELLLSDGGEATGPSVRGLNSMVTQLRLSFQAQEDRRSWARHPVSMAASFEDGLYVQTVVDAIKRSNRTGEWESVEVKIQEVDPNHNHRTLPN", "length": 367 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HZN3-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "Gfod2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNITFYTSRTDDVLLHQDVDLVCINIPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSPSYGWICDELMGGGGLHTMGTYIVDLLTHVTGRKAEKVHGLLKTFVRQNATIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSATQEELLVRDSLAVGAGLPEQGLQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWETVEMLTEEPDANQNLCEALQRNNL", "length": 385 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LDU2-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "GFOD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKMLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNITFYTSRTDDVLLHQDVDLVCINIPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARVYSGSLLSPNYGWICDELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNAAIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSATQEELLLRDSLAVGTELPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDHTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWEAVEVLTEEPDANQNLCEALQRNNL", "length": 385 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3B7J2-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "GFOD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKMLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNIAFYTSRTDDILLHQDVDLVCISIPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLISEHYVGAVMICDARIYSGSLLSPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNAAIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSATQEELLLRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWEAVEVLTEEPDTNQNLCEALQRNNL", "length": 385 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CYH5-1", "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "Gfod2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNITFYTSRTDDVLLHQDVDLVCINIPPPLTRQISVKALGIGKNVVCEKAATSMDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVHGLLKTFVRQNATIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWETVEMLAEEPDANQNLSETLQRNNL", "length": 385 }, "evidence": [ { "id": "Q5BIP5", "url": "https://omabrowser.org/oma/group/Q5BIP5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP5", "url": "https://www.uniprot.org/uniprotkb/Q5BIP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIP5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 385, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIP5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIP5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5DPW9-1", "uniprot_ac": "Q5DPW9", "uniprot_id": "Q5DPW9_BOVIN", "mass": { "chemical_mass": 16356.0, "monoisotopic_mass": 16356.0 }, "refseq": { "ac": "NP_001012782", "name": "cystatin-M precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012782" }, "gene_names": [ { "name": "CST6", "type": "recommended", "evidence": [ { "id": "Q5DPW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" } ] }, { "name": "CST6", "type": "synonym", "evidence": [ { "id": "NP_001012782", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012782" } ] } ], "protein_names": [ { "name": "Cystatin E/M", "type": "synonym", "evidence": [ { "id": "Q5DPW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9/entry#names_and_taxonomy" } ] }, { "name": "cystatin-M precursor", "type": "synonym", "evidence": [ { "id": "NP_001012782", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012782" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5DPW9", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CST6", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9", "locus": { "chromosome": "29", "start_pos": 44102573, "end_pos": 44101083, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046587", "url": "https://www.ensembl.org/id/ENSBTAG00000046587" } ] } } ], "crossref": [ { "id": "ENSBTAG00000046587", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046587", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "503685", "url": "https://www.ncbi.nlm.nih.gov/gene/503685", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:503685", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503685", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ILVVPWQ", "url": "https://omabrowser.org/oma/group/ILVVPWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5DPW9", "url": "https://www.orthodb.org/?gene=Q5DPW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47033:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47033:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001012782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012782", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5DPW9", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5DPW9-1", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPSLLLPMALALLALCLLALPRDARARPGDRKVGELQELSPNDPQVQKAAQVAVANYNMGSNSDYYYRDITILRAHSQLVAGIKYYLTVDMGSTACRKSAVAGDHVDLTTCPLAAEAQQEKLRCDFEILVVPWKNSSQLLKHDCVSL", "length": 149, "header": "tr|Q5DPW9-1|Q5DPW9_BOVIN Isoform 1 of Cystatin E/M OS=Bos taurus OX=9913 GN=CST6 PE=3 SV=1 CANONICAL=Q5DPW9-1" }, "isoforms": [ { "isoform_ac": "Q5DPW9-1", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9/entry#Q5DPW9-1", "sequence": { "sequence": "MARPSLLLPMALALLALCLLALPRDARARPGDRKVGELQELSPNDPQVQKAAQVAVANYNMGSNSDYYYRDITILRAHSQLVAGIKYYLTVDMGSTACRKSAVAGDHVDLTTCPLAAEAQQEKLRCDFEILVVPWKNSSQLLKHDCVSL", "length": 149, "header": "tr|Q5DPW9-1|Q5DPW9_BOVIN Isoform 1 of Cystatin E/M OS=Bos taurus OX=9913 GN=CST6 PE=3 SV=1 CANONICAL=Q5DPW9-1" }, "locus": { "chromosome": "29", "start_pos": 44102443, "end_pos": 44101121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064987.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064987.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056554.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056554.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:503685", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503685", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RU34-1", "protein_name": "Cystatin E/M", "gene_name": "CST6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARHSLPLSMGLALLAFCLLALPRDARGRPGERRVGEPQDLSPSDPQVQHAAQVAVANYNMGSNSLYYFRDTTILRAQSQLVAGIKYYLTLEMGSTACRKNAVAGDRIDLATCPLAVGAQQEKLRCDFEILVVPWQNSSQLLKQDCVSL", "length": 149 }, "evidence": [ { "id": "Q5DPW9", "url": "https://omabrowser.org/oma/group/Q5DPW9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15828-1", "protein_name": "Cystatin-M", "gene_name": "CST6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARSNLPLALGLALVAFCLLALPRDARARPQERMVGELRDLSPDDPQVQKAAQAAVASYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAAGAQQEKLRCDFEVLVVPWQNSSQLLKHNCVQM", "length": 149 }, "evidence": [ { "id": "Q5DPW9", "url": "https://omabrowser.org/oma/group/Q5DPW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5DPW9", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "Q5DPW9", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "Q5DPW9", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5DPW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5DPW9" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 147, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E943-1", "uniprot_ac": "Q5E943", "uniprot_id": "LTAP1_BOVIN", "mass": { "chemical_mass": 28673.0, "monoisotopic_mass": 28673.0 }, "refseq": {}, "gene_names": [ { "name": "LTAP1", "type": "recommended", "evidence": [ { "id": "Q5E943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ] } ], "protein_names": [ { "name": "Lipid transport auxiliary protein 1", "type": "recommended", "evidence": [ { "id": "Q5E943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E943/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for the formation of endoplasmic reticulum-plasma membrane junctions and functions as an accessory protein for bridge-like lipid transfer protein BLTP1, participating in lipid delivery between endoplasmic reticulum and cell membranes (By similarity). Regulates the phagocytosis of Gram-negative bacteria like L. pneumophila and E. coli, as well as Gram-positive bacteria such as S. aureus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943#function" }, { "database": "UniProtKB", "id": "Q9BWL3", "url": "https://www.uniprot.org/uniprotkb/Q9BWL3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LTAP1", "url": "https://www.uniprot.org/uniprotkb/Q5E943", "locus": {} } ], "crossref": [ { "id": "Q5E943", "url": "https://alphafold.ebi.ac.uk/entry/Q5E943", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538459", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538459", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E943", "url": "https://www.orthodb.org/?gene=Q5E943", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21425", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21425", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21425:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21425:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07406", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07406", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E943-1", "url": "https://www.uniprot.org/uniprotkb/Q5E943-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNHNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 253, "header": "sp|Q5E943-1|LTAP1_BOVIN Isoform 1 of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=LTAP1 PE=2 SV=1 CANONICAL=Q5E943-1" }, "isoforms": [ { "isoform_ac": "Q5E943-1", "url": "https://www.uniprot.org/uniprotkb/Q5E943/entry#Q5E943-1", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNHNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 253, "header": "sp|Q5E943-1|LTAP1_BOVIN Isoform 1 of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=LTAP1 PE=2 SV=1 CANONICAL=Q5E943-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538459", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" }, { "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "Q5E943", "url": "https://www.uniprot.org/uniprotkb/Q5E943" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E943-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 253, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E943-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E943" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E948-1", "uniprot_ac": "Q5E948", "uniprot_id": "OCAD1_BOVIN", "mass": { "chemical_mass": 27829.0, "monoisotopic_mass": 27829.0 }, "refseq": { "ac": "NP_001015648", "name": "OCIA domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015648" }, "gene_names": [ { "name": "Ociad1", "type": "recommended", "evidence": [ { "id": "Q5E948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ] }, { "name": "Asrij", "type": "synonym", "evidence": [ { "id": "NP_001015648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015648" }, { "id": "Q5E948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ] }, { "name": "OCIAD1", "type": "synonym", "evidence": [ { "id": "NP_001015648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015648" } ] } ], "protein_names": [ { "name": "OCIA domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q5E948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E948/entry#names_and_taxonomy" } ] }, { "name": "OCIA domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015648" } ] } ], "function": [ { "annotation": "Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948#function" }, { "database": "UniProtKB", "id": "Q9CRD0", "url": "https://www.uniprot.org/uniprotkb/Q9CRD0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "Ociad1", "url": "https://www.uniprot.org/uniprotkb/Q5E948", "locus": {} } ], "crossref": [ { "id": "Q5E948", "url": "https://alphafold.ebi.ac.uk/entry/Q5E948", "database": "AlphaFoldDB", "categories": [] }, { "id": "533520", "url": "https://www.ncbi.nlm.nih.gov/gene/533520", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533520", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533520", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E948", "url": "https://www.orthodb.org/?gene=Q5E948", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13336:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13336:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E948-1", "url": "https://www.uniprot.org/uniprotkb/Q5E948-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGRADFREPNAEVPRPIPHIGADYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLIFACIMGYFAGKLSYVKTCQEKFKNLENSPLGEALRSGQARRSSPTGHYSQRSKYDSNVSGHSSFGTSPAADNLEKEMLPHYEPIPFSASLNESTPTGITDHIAQGPDPNTEESPKRKNITYEELRNKNRESYEVTLTHKTDPSVRPMQERMPKKEVKVNKYGDTWDE", "length": 247, "header": "sp|Q5E948-1|OCAD1_BOVIN Isoform 1 of OCIA domain-containing protein 1 OS=Bos taurus OX=9913 GN=Ociad1 PE=2 SV=1 CANONICAL=Q5E948-1" }, "isoforms": [ { "isoform_ac": "Q5E948-1", "url": "https://www.uniprot.org/uniprotkb/Q5E948/entry#Q5E948-1", "sequence": { "sequence": "MNGRADFREPNAEVPRPIPHIGADYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLIFACIMGYFAGKLSYVKTCQEKFKNLENSPLGEALRSGQARRSSPTGHYSQRSKYDSNVSGHSSFGTSPAADNLEKEMLPHYEPIPFSASLNESTPTGITDHIAQGPDPNTEESPKRKNITYEELRNKNRESYEVTLTHKTDPSVRPMQERMPKKEVKVNKYGDTWDE", "length": 247, "header": "sp|Q5E948-1|OCAD1_BOVIN Isoform 1 of OCIA domain-containing protein 1 OS=Bos taurus OX=9913 GN=Ociad1 PE=2 SV=1 CANONICAL=Q5E948-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "site_lbl": "Ser108" }, { "start_pos": 116, "end_pos": 116, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "site_lbl": "Ser116" }, { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "site_lbl": "Ser123" }, { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "site_lbl": "Ser193" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533520", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533520", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of stem cell differentiation", "id": "GO:2000736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000736", "evidence": [ { "database": "UniProtKB", "id": "Q5E948", "url": "https://www.uniprot.org/uniprotkb/Q5E948" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E948-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E948-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E948" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 108, 116, 123, 193 ], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E977-1", "uniprot_ac": "Q5E977", "uniprot_id": "F118B_BOVIN", "mass": { "chemical_mass": 39537.0, "monoisotopic_mass": 39537.0 }, "refseq": { "ac": "NP_001015677", "name": "protein FAM118B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015677" }, "gene_names": [ { "name": "FAM118B", "type": "recommended", "evidence": [ { "id": "Q5E977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ] }, { "name": "FAM118B", "type": "synonym", "evidence": [ { "id": "NP_001015677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015677" } ] } ], "protein_names": [ { "name": "Protein FAM118B", "type": "recommended", "evidence": [ { "id": "Q5E977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E977/entry#names_and_taxonomy" } ] }, { "name": "protein FAM118B", "type": "synonym", "evidence": [ { "id": "NP_001015677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015677" } ] } ], "function": [ { "annotation": "May play a role in Cajal bodies formation.", "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977#function" }, { "database": "UniProtKB", "id": "Q9BPY3", "url": "https://www.uniprot.org/uniprotkb/Q9BPY3#function" }, { "database": "UniProtKB", "id": "A0AAA9SHC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHC7#function" }, { "database": "UniProtKB", "id": "ARBA00003199", "url": "https://www.uniprot.org/uniprotkb/ARBA00003199#function" }, { "database": "UniProtKB", "id": "A0AAA9TDA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA0#function" }, { "database": "UniProtKB", "id": "A0AAF6YXD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM118B", "url": "https://www.uniprot.org/uniprotkb/Q5E977", "locus": { "chromosome": "29", "start_pos": 29615982, "end_pos": 29562032, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012169", "url": "https://www.ensembl.org/id/ENSBTAG00000012169" } ] } } ], "crossref": [ { "id": "Q5E977", "url": "https://alphafold.ebi.ac.uk/entry/Q5E977", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540626", "url": "https://www.ncbi.nlm.nih.gov/gene/540626", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540626", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540626", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGKQNEL", "url": "https://omabrowser.org/oma/group/WGKQNEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E977", "url": "https://www.orthodb.org/?gene=Q5E977", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28623", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28623", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28623:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28623:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13289", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13289", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015677", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E977-1", "url": "https://www.uniprot.org/uniprotkb/Q5E977-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTGSQASDIDKILGFFSDGAPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSAGIVREGQLNGSSTAHSEIRDHST", "length": 351, "header": "sp|Q5E977-1|F118B_BOVIN Isoform 1 of Protein FAM118B OS=Bos taurus OX=9913 GN=FAM118B PE=2 SV=1 CANONICAL=Q5E977-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHC7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E977/entry#A0AAA9SHC7-1", "sequence": { "sequence": "MASTGSQASDIDKILGFFSDGAPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSGIVREGQLNGSSTAHSEIREGRPLTEGAAESHSGNRKCHSIDLRHSAVGSQCGTCLETAGERRLSTCPHTSVLGSSE", "length": 404, "header": "tr|A0AAA9SHC7-1|A0AAA9SHC7_BOVIN Computationally mapped isoform of Protein FAM118B OS=Bos taurus OX=9913 GN=FAM118B PE=3 SV=1 CANONICAL=Q5E977-1" }, "locus": { "chromosome": "29", "start_pos": 29615982, "end_pos": 29586348, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111413.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111413.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085609.1" } ] } }, { "isoform_ac": "A0AAA9TDA0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E977/entry#A0AAA9TDA0-1", "sequence": { "sequence": "MASTGSQASDIDKILGFFSDGAPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSAGIVREGQLNGSSTAHSEIRDHST", "length": 275, "header": "tr|A0AAA9TDA0-1|A0AAA9TDA0_BOVIN Computationally mapped isoform of Protein FAM118B OS=Bos taurus OX=9913 GN=FAM118B PE=3 SV=1 CANONICAL=Q5E977-1" }, "locus": { "chromosome": "29", "start_pos": 29610072, "end_pos": 29586348, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094123.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094123.1" } ] } }, { "isoform_ac": "A0AAF6YXD8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E977/entry#A0AAF6YXD8-1", "sequence": { "sequence": "MAHPPPRSPGCSQASYLFDPFRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSGIVREGQLNGSSTAHSEIRDHST", "length": 343, "header": "tr|A0AAF6YXD8-1|A0AAF6YXD8_BOVIN Computationally mapped isoform of Protein FAM118B OS=Bos taurus OX=9913 GN=FAM118B PE=3 SV=1 CANONICAL=Q5E977-1" }, "locus": { "chromosome": "29", "start_pos": 29610072, "end_pos": 29586348, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016141.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016141.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016141.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016141.7" } ] } }, { "isoform_ac": "Q5E977-1", "url": "https://www.uniprot.org/uniprotkb/Q5E977/entry#Q5E977-1", "sequence": { "sequence": "MASTGSQASDIDKILGFFSDGAPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSAGIVREGQLNGSSTAHSEIRDHST", "length": 351, "header": "sp|Q5E977-1|F118B_BOVIN Isoform 1 of Protein FAM118B OS=Bos taurus OX=9913 GN=FAM118B PE=2 SV=1 CANONICAL=Q5E977-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540626", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540626", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7H6X1-1", "protein_name": "Protein FAM118B", "gene_name": "LOC100761927", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASTGSQASDIDKIFGFFNDGEPPTKKPRKLLPSLKTRKPRELVLVIGTGISAAVAPQVPALKSWKGLFQALLDAAIDFDLLEDEESKKFQKYLHGDKNLVHVAHDLIQKLSLHTSNVGYTFFKDCLYEVFDDLESKMGDSGKQLLQSVLHLMENGALILTTNFDNLLELYAADQGKQLESLDLTDEKKKKVLEWAQEKWKLSVSHIYGVYPNPSGIVLHPAGYQNVLRNTEVRREIQKLYENKSFLFLGCGWTVDNTTFQALFLEAVKHKSDLEHFMLVRRGDVXEFKKLRENMLDEGIKVISYGNDYADLPEYFKQLTYEISTRGRPGMAREGHLNGSSAAHREIRGCST", "length": 352 }, "evidence": [ { "id": "Q5E977", "url": "https://omabrowser.org/oma/group/Q5E977/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4QQT2-1", "protein_name": "Protein FAM118B", "gene_name": "Fam118b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTGSQASDIDKIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSGMAREGQLNGSSAAHGEIRGCST", "length": 350 }, "evidence": [ { "id": "Q5E977", "url": "https://omabrowser.org/oma/group/Q5E977/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C569-1", "protein_name": "Protein FAM118B", "gene_name": "Fam118b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTGSQASDKNKIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSAGMAREGQLNGSSAAHGEIRGCST", "length": 351 }, "evidence": [ { "id": "Q5E977", "url": "https://omabrowser.org/oma/group/Q5E977/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BPY3-1", "protein_name": "Protein FAM118B", "gene_name": "FAM118B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGDDYADLPEYFKRLTCEISTRGTSAGMVREGQLNGSSAAHSEIRGCST", "length": 351 }, "evidence": [ { "id": "Q5E977", "url": "https://omabrowser.org/oma/group/Q5E977/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5E977", "url": "https://www.uniprot.org/uniprotkb/Q5E977" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E977-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E977-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E977" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9 ], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 337, "end_pos": 339 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E980-1", "uniprot_ac": "Q5E980", "uniprot_id": "CP20A_BOVIN", "mass": { "chemical_mass": 52674.0, "monoisotopic_mass": 52674.0 }, "refseq": { "ac": "NP_001015644", "name": "cytochrome P450 20A1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015644" }, "gene_names": [ { "name": "CYP20A1", "type": "recommended", "evidence": [ { "id": "Q5E980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ] }, { "name": "CYP20A1", "type": "synonym", "evidence": [ { "id": "NP_001015644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015644" } ] } ], "protein_names": [ { "name": "Cytochrome P450 20A1", "type": "recommended", "evidence": [ { "id": "Q5E980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E980/entry#names_and_taxonomy" } ] }, { "name": "1.14.-.-", "type": "synonym", "evidence": [ { "id": "Q5E980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E980/entry#names_and_taxonomy" } ] }, { "name": "cytochrome P450 20A1", "type": "synonym", "evidence": [ { "id": "NP_001015644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015644" } ] }, { "name": "cytochrome P450, family 20, subfamily A, polypeptide 1", "type": "synonym", "evidence": [ { "id": "NP_001015644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015644" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP20A1", "url": "https://www.uniprot.org/uniprotkb/Q5E980", "locus": { "chromosome": "2", "start_pos": 91528299, "end_pos": 91483583, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000851", "url": "https://www.ensembl.org/id/ENSBTAG00000000851" } ] } } ], "crossref": [ { "id": "Q5E980", "url": "https://alphafold.ebi.ac.uk/entry/Q5E980", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000851", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20627", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20627", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532945", "url": "https://www.ncbi.nlm.nih.gov/gene/532945", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532945", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532945", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFQVWSE", "url": "https://omabrowser.org/oma/group/YFQVWSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E980", "url": "https://www.orthodb.org/?gene=Q5E980", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24280", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24280", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24280:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24280:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015644", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E980-1", "url": "https://www.uniprot.org/uniprotkb/Q5E980-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTLDPFETMLKSLLRYQSDSGNVSENHMRKKLYENGVTNCLRSNFALLIKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVMGSTFEDEQEVIRFQKNHGTVWSEIGKGFLDGSLDKSTTRKKQYEDALMQLESILKKIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDTMIFSLASCMITAKLCTWAVCFLTTYEEIQKKLYEEIDQVLGKGPITSEKIEELRYCRQVLCETVRTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVVLQDPGTWSSPYKFDPERFDDESVMKTFSLLGFSGTRECPELRFAYMVTAVLLSVLLRRLHLLSVEGQVIETKYELVTSSKEEAWITVSKRY", "length": 462, "header": "sp|Q5E980-1|CP20A_BOVIN Isoform 1 of Cytochrome P450 20A1 OS=Bos taurus OX=9913 GN=CYP20A1 PE=2 SV=1 CANONICAL=Q5E980-1" }, "isoforms": [ { "isoform_ac": "Q5E980-1", "url": "https://www.uniprot.org/uniprotkb/Q5E980/entry#Q5E980-1", "sequence": { "sequence": "MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTLDPFETMLKSLLRYQSDSGNVSENHMRKKLYENGVTNCLRSNFALLIKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVMGSTFEDEQEVIRFQKNHGTVWSEIGKGFLDGSLDKSTTRKKQYEDALMQLESILKKIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDTMIFSLASCMITAKLCTWAVCFLTTYEEIQKKLYEEIDQVLGKGPITSEKIEELRYCRQVLCETVRTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVVLQDPGTWSSPYKFDPERFDDESVMKTFSLLGFSGTRECPELRFAYMVTAVLLSVLLRRLHLLSVEGQVIETKYELVTSSKEEAWITVSKRY", "length": 462, "header": "sp|Q5E980-1|CP20A_BOVIN Isoform 1 of Cytochrome P450 20A1 OS=Bos taurus OX=9913 GN=CYP20A1 PE=2 SV=1 CANONICAL=Q5E980-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532945", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532945", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1QHW0-1", "protein_name": "Cytochrome P450 20A1", "gene_name": "cyp20a1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLDFAIFAVTFVIILIGAVLYLYPSSRRASGVPGLNPTEEKDGNLQDIVNKGSLHEFLVGLHDEFGSVASFWFGARPVVSLGAVNQLRQHINPNWTTDSFETMLKSLLGYQSGSGVGLTESMMRKKVYEGAINKTLENNFPLLLQQVEELVDKWASYPKSQHMPLCAHLLGLAMKAVTQLAMGSRFRDDAEVIRFRKNHEAIWSEIGKGYLDGSLEKSSSRKAHYESALAEMESVLKSVAKQRPGQGSSQSSFVNYLLQANLTERQVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEVLGDEPVSLEKIPQLRYCQQVLNETVRTAKLTPVAARLQEVEGKVDQHVIPKETLVIYALGVVLQDADTWSLPYRFNPDRFAEESVMKSFSLLGFSGSQACPELRFAYTVATVLLSTLVRRLRMHRVDGQVVEARYELVTTPKDDTWITVSKRN", "length": 463 }, "evidence": [ { "id": "Q5E980", "url": "https://omabrowser.org/oma/group/Q5E980/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P7D4-1", "protein_name": "Cytochrome P450 20A1", "gene_name": "Cyp20a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLDFAIFAVTFLLALVGAVLYLYPASRQASGIPGLTPTEEKDGNLPDIVNSGSLHEFLVNLHGRYGPVVSFWFGRRLVVSLGTADALKQHFNPNKTLDPFETMLKSLLGYRSGAGSGSEDHVRRRLYGDAVTAALQSNFPLLLKLSEELLDKWLSYPETQHIPLSQHMLGFALKFVTRMVLGDTFEGEQEVIRFQKIHGTVWSEIGKGFLDGSLDKNTTRKNQYQEALMQLEAILKKIIKERKGGDFSQHTFIDSLVQRNLNEQQILEDSVVFSLAGCIVTARLCTWAIHFLTTAEEVQKKLHKEVDHVLGKGPITSEKIEQLRYCQQVLCETVRTAKLTPVSAQLQDIEGKVGPFIIPKETLVLYALGVVLQDASTWPSPHKFDPDRFADEPVMKVFSSLGFSGTWECPELRFAYVVTTVLVSVLLKKLHLLAVDRQVFEMKYELVTSCREETWITVSERH", "length": 462 }, "evidence": [ { "id": "Q5E980", "url": "https://omabrowser.org/oma/group/Q5E980/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UW02-1", "protein_name": "Cytochrome P450 20A1", "gene_name": "CYP20A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY", "length": 462 }, "evidence": [ { "id": "Q5E980", "url": "https://omabrowser.org/oma/group/Q5E980/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BKE6-1", "protein_name": "Cytochrome P450 20A1", "gene_name": "Cyp20a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLDFAIFAVTFLLALVGAVLYLYPASRQASGIPGLTPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTTDVLKQHFNPNKTSDPFETMLKSLLGYQSGGGSAGEDHVRRKLYGDAVTASLHSNFPLLLQLSEELLDKWLSYPETQHIPLSQHMLGFALKFVTRMVLGSTFEDEQEVIRFQKIHGTVWSEIGKGFLDGSLDKNTTRKKQYQEALMQLESTLKKIIKERKGGNFRQHTFIDSLTQGKLNEQQILEDCVVFSLASCIITARLCTWTIHFLTTTGEVQKKLCKEIDQVLGEGPITSEKIEQLSYCQQVLFETVRTAKLTPVSARLQDIEGKVGPFVIPKETLVLYALGVVLQDPSTWPLPHRFDPDRFADEPVMKVFSSLGFSGTWECPELRFAYMVTAVLVSVLLKRLRLLAVDRQVFEMKYELVTSAREEAWITVSKRH", "length": 462 }, "evidence": [ { "id": "Q5E980", "url": "https://omabrowser.org/oma/group/Q5E980/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E980", "url": "https://www.uniprot.org/uniprotkb/Q5E980" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E980-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 462, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E980-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E980" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9A0-1", "uniprot_ac": "Q5E9A0", "uniprot_id": "OSER1_BOVIN", "mass": { "chemical_mass": 31719.0, "monoisotopic_mass": 31719.0 }, "refseq": { "ac": "NP_001015568", "name": "oxidative stress-responsive serine-rich protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" }, "gene_names": [ { "name": "OSER1", "type": "recommended", "evidence": [ { "id": "Q5E9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ] }, { "name": "C13H20orf111", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] }, { "name": "C20orf111", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] }, { "name": "OSER1", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] } ], "protein_names": [ { "name": "Oxidative stress-responsive serine-rich protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0/entry#names_and_taxonomy" } ] }, { "name": "Oxidative stress-responsive protein 1", "type": "synonym", "evidence": [ { "id": "Q5E9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0/entry#names_and_taxonomy" } ] }, { "name": "Peroxide-inducible transcript 1 protein", "type": "synonym", "evidence": [ { "id": "Q5E9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0/entry#names_and_taxonomy" } ] }, { "name": "oxidative stress-responsive protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] }, { "name": "oxidative stress-responsive serine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] }, { "name": "peroxide-inducible transcript 1 protein", "type": "synonym", "evidence": [ { "id": "NP_001015568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OSER1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0", "locus": { "chromosome": "13", "start_pos": 72669119, "end_pos": 72679486, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016873", "url": "https://www.ensembl.org/id/ENSBTAG00000016873" } ] } } ], "crossref": [ { "id": "Q5E9A0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9A0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510457", "url": "https://www.ncbi.nlm.nih.gov/gene/510457", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510457", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510457", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KACQCKL", "url": "https://omabrowser.org/oma/group/KACQCKL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9A0", "url": "https://www.orthodb.org/?gene=Q5E9A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31383:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31383:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015568", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSIASLSVGEGASVRASVRAAVEDAKPKSACASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSQLKHKSQTDSPDGSSGLGISTPKEFNAGECSSSLDTNHTGAVAEPLRTSVPRLPSESKEEDSSDAPQVSQASLQANDLSDFQSVSKLNLGKPCVCIGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 291, "header": "sp|Q5E9A0-1|OSER1_BOVIN Isoform 1 of Oxidative stress-responsive serine-rich protein 1 OS=Bos taurus OX=9913 GN=OSER1 PE=2 SV=1 CANONICAL=Q5E9A0-1" }, "isoforms": [ { "isoform_ac": "Q5E9A0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0/entry#Q5E9A0-1", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSIASLSVGEGASVRASVRAAVEDAKPKSACASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSQLKHKSQTDSPDGSSGLGISTPKEFNAGECSSSLDTNHTGAVAEPLRTSVPRLPSESKEEDSSDAPQVSQASLQANDLSDFQSVSKLNLGKPCVCIGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 291, "header": "sp|Q5E9A0-1|OSER1_BOVIN Isoform 1 of Oxidative stress-responsive serine-rich protein 1 OS=Bos taurus OX=9913 GN=OSER1 PE=2 SV=1 CANONICAL=Q5E9A0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ], "site_lbl": "Thr142" }, { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ], "site_lbl": "Thr232" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510457", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510457", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AFP1-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "OSER1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSIASLSVGEGTSVRASVRTAADDTKLKTTCASKDSWHGSTRKSSRGAVRTPRRRRSKSPVLHPPKFIHCSTIAAASSCQLKHKSQTDSPDGSSGLGISPPKEFNTGECSPSLDSNHTGAVVEPLRTSVPRLPSESKEEDSSDVPQVSQASLKANDLSDFQSVSKLNQGKPCTCVGKECQCQRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 292 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HD20-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "Oser1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSISSLSVGEGTSGRASVRTAADDMKPKTTCASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTTASPPSSQLKHRSQTEPPDGSSGLGISSPKEFNTGETSTSLDVNHTGAVIEPLRSSVPRLPSESKTEEPSDATQVSQESLTASDLSDFRSVSKLSQGKPCACVGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSLEDCSPSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 291 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZW67-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "OSER1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMKTEAKDGEEESLQTAFKKLRVDAAGSTASLSIGEGTSPRALVRAAADETKPKNACTSKETWHGSMKKPSRGAVRTQRRRRSKSPILHPPKFIHCSTKSQSTCNQLVHKGQIDAPADGNAFGILVPKEARAHERCSVASDIGQKRDGVGSPGASVAQPTSVNTQENSPTAISLVSEASLKTEELSDFRSVSKLNKNNPCACVDKACQCKRWQDMEVYKFSGLQNTFTLASDRRTVAEDHSQSLPSRTPSSSPRSCSEQARAFVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 295 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q703I1-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "Oser1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSIVSLSVGEGTSVRASVRTTVDDTKPKTMCAPKDSWHGSTRKSSRGAVRIQRRRRSKSPVLHPPKFIHCSTTASPSSSQLKQRSQTEPLDGSSGRGISTPKEFSTGENSTSLDINHTGAAIEPLRSSVLRLPSESKTEELSDATQVSPESLTANDLSDFQSVSKLSQGKPCVCVGKACQCKRWHDMEVYSFSGLQNVPPLAPERRSLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLAGYMEYYLYIPKKMSHMAEMMYT", "length": 291 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D722-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "Oser1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSIISLSVGEGPSVRASARTAADDTKPKTMCASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTTAPPSSSQLKHRSQTEPPDGISGRGISTPKEFNAGENSTSLDVNHTGAAIEPLRSSVLRLPSESKTEELSDATQVSQESLTANDLSDFQSVSKLSQGKPCVCVGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLAGYMEYYLYIPKKMSHMAEMMYT", "length": 291 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX31-1", "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "OSER1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKSEAKDGEEESLQTAFKKLRVDASGSVASLSVGEGTGVRAPVRTATDDTKPKTTCASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSSQLKHKSQTDSPDGSSGLGISSPKEFSAGESSTSLDANHTGAVVEPLRTSVPRLPSESKKEDSSDATQVPQASLKASDLSDFQSVSKLNQGKPCTCIGKECQCKRWHDMEVYSFSGLQSVPPLAPERRSTLEDYSQSLHARTLSGSPRSCSEQARVFVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 292 }, "evidence": [ { "id": "Q5E9A0", "url": "https://omabrowser.org/oma/group/Q5E9A0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A0", "url": "https://www.uniprot.org/uniprotkb/Q5E9A0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9A0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9A0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9A0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 142, 232 ], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9A5-1", "uniprot_ac": "Q5E9A5", "uniprot_id": "GA45B_BOVIN", "mass": { "chemical_mass": 17806.0, "monoisotopic_mass": 17806.0 }, "refseq": { "ac": "NP_001035694", "name": "growth arrest and DNA damage-inducible protein GADD45 beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035694" }, "gene_names": [ { "name": "GADD45B", "type": "recommended", "evidence": [ { "id": "Q5E9A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ] }, { "name": "GADD45B", "type": "synonym", "evidence": [ { "id": "NP_001035694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035694" } ] } ], "protein_names": [ { "name": "Growth arrest and DNA damage-inducible protein GADD45 beta", "type": "recommended", "evidence": [ { "id": "Q5E9A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5/entry#names_and_taxonomy" } ] }, { "name": "growth arrest and DNA damage-inducible protein GADD45 beta", "type": "synonym", "evidence": [ { "id": "NP_001035694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035694" } ] }, { "name": "myeloid differentiation primary response", "type": "synonym", "evidence": [ { "id": "NP_001035694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035694" } ] } ], "function": [ { "annotation": "Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GADD45B", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5", "locus": { "chromosome": "7", "start_pos": 21118048, "end_pos": 21120170, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025462", "url": "https://www.ensembl.org/id/ENSBTAG00000025462" } ] } } ], "crossref": [ { "id": "Q5E9A5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9A5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025462", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025462", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618405", "url": "https://www.ncbi.nlm.nih.gov/gene/618405", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618405", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618405", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCEESRE", "url": "https://omabrowser.org/oma/group/YCEESRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9A5", "url": "https://www.orthodb.org/?gene=Q5E9A5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10411:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10411:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035694", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLEELVACDNAAQKMQTVSAAVEELLVAAQLQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCENDIDIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDTWKSHGLVEVASYCEESRGNNQWVPYISLQER", "length": 160, "header": "sp|Q5E9A5-1|GA45B_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 beta OS=Bos taurus OX=9913 GN=GADD45B PE=2 SV=1 CANONICAL=Q5E9A5-1" }, "isoforms": [ { "isoform_ac": "Q5E9A5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5/entry#Q5E9A5-1", "sequence": { "sequence": "MTLEELVACDNAAQKMQTVSAAVEELLVAAQLQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCENDIDIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDTWKSHGLVEVASYCEESRGNNQWVPYISLQER", "length": 160, "header": "sp|Q5E9A5-1|GA45B_BOVIN Isoform 1 of Growth arrest and DNA damage-inducible protein GADD45 beta OS=Bos taurus OX=9913 GN=GADD45B PE=2 SV=1 CANONICAL=Q5E9A5-1" }, "locus": { "chromosome": "7", "start_pos": 21119949, "end_pos": 21118691, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035803.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035803.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035670.3", "url": "https://www.ensembl.org/id/ENSBTAP00000035670.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:618405", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618405", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A5", "url": "https://www.uniprot.org/uniprotkb/Q5E9A5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9A5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 160, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9A5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9A5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9A6-1", "uniprot_ac": "Q5E9A6", "uniprot_id": "VPS25_BOVIN", "mass": { "chemical_mass": 20747.0, "monoisotopic_mass": 20747.0 }, "refseq": { "ac": "NP_001015657", "name": "vacuolar protein-sorting-associated protein 25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015657" }, "gene_names": [ { "name": "VPS25", "type": "recommended", "evidence": [ { "id": "Q5E9A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ] }, { "name": "VPS25", "type": "synonym", "evidence": [ { "id": "NP_001015657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015657" } ] } ], "protein_names": [ { "name": "Vacuolar protein-sorting-associated protein 25", "type": "recommended", "evidence": [ { "id": "Q5E9A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6/entry#names_and_taxonomy" } ] }, { "name": "ESCRT-II complex subunit VPS25", "type": "synonym", "evidence": [ { "id": "NP_001015657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015657" }, { "id": "Q5E9A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6/entry#names_and_taxonomy" } ] }, { "name": "vacuolar protein-sorting-associated protein 25", "type": "synonym", "evidence": [ { "id": "NP_001015657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015657" } ] } ], "function": [ { "annotation": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS25", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6", "locus": { "chromosome": "19", "start_pos": 42810402, "end_pos": 42805111, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019906", "url": "https://www.ensembl.org/id/ENSBTAG00000019906" } ] } } ], "crossref": [ { "id": "Q5E9A6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9A6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019906", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019906", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534750", "url": "https://www.ncbi.nlm.nih.gov/gene/534750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRCLIMW", "url": "https://omabrowser.org/oma/group/TRCLIMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9A6", "url": "https://www.orthodb.org/?gene=Q5E9A6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13149:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13149:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05871", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05871", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015657", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TLS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7J4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLTFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQVVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSKSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 176, "header": "sp|Q5E9A6-1|VPS25_BOVIN Isoform 1 of Vacuolar protein-sorting-associated protein 25 OS=Bos taurus OX=9913 GN=VPS25 PE=2 SV=1 CANONICAL=Q5E9A6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLS1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6/entry#A0AAA9TLS1-1", "sequence": { "sequence": "MAALNHGSRAISRGSRNLSAALSVRTCRSGDRKSFAGGSRVSWGTTMAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLTFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQVVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVTTSPEHSREREEGKQQQQPKYNKHTPPISEQENNQDERFPRVARTTPCSPCMN", "length": 214, "header": "tr|A0AAA9TLS1-1|A0AAA9TLS1_BOVIN Computationally mapped isoform of Vacuolar protein-sorting-associated protein 25 OS=Bos taurus OX=9913 GN=VPS25 PE=4 SV=1 CANONICAL=Q5E9A6-1" }, "locus": { "chromosome": "19", "start_pos": 42808214, "end_pos": 42805221, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092256.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092256.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099401.1" } ] } }, { "isoform_ac": "A0AAF6Z7J4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6/entry#A0AAF6Z7J4-1", "sequence": { "sequence": "MESRDLRLEIEDVGEVRQRWLCSNMAALNHGSRAISRGSRNLSAALSVRTCRSGDRKSFAGGSRVSWGTTMAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLTFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQVVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSKSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 246, "header": "tr|A0AAF6Z7J4-1|A0AAF6Z7J4_BOVIN Computationally mapped isoform of Vacuolar protein-sorting-associated protein 25 OS=Bos taurus OX=9913 GN=VPS25 PE=3 SV=1 CANONICAL=Q5E9A6-1" }, "locus": { "chromosome": "19", "start_pos": 42809889, "end_pos": 42805149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026518.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026518.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026518.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026518.5" } ] } }, { "isoform_ac": "Q5E9A6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6/entry#Q5E9A6-1", "sequence": { "sequence": "MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLTFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQVVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSKSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 176, "header": "sp|Q5E9A6-1|VPS25_BOVIN Isoform 1 of Vacuolar protein-sorting-associated protein 25 OS=Bos taurus OX=9913 GN=VPS25 PE=2 SV=1 CANONICAL=Q5E9A6-1" }, "locus": { "chromosome": "19", "start_pos": 42809889, "end_pos": 42805687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140084.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140084.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105131.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534750", "resource": "KEGG Pathway" }, { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AAM6-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "VPS25", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSTRTSRGGDRKSFAAGFRGSWATTMAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQVVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 202 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0C0A1-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Vps25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTSGEDTEEEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 176 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47142-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "VPS25", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSALPPVYSFPPLYTRQPNSLTRRQQISTWIDIISQYCKTKKIWYMSVDGTVINDNELDSGSTDNDDSKKISKNLFNNEDIQRSVSQVFIDEIWSQMTKEGKCLPIDQSGRRSSNTTTTRYFILWKSLDSWASLILQWFEDSGKLNQVITLYELSEGDETVNWEFHRMPESLLYYCLKPLCDRNRATMLKDENDKVIAIKVV", "length": 202 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55GD9-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "vps25", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNQVFQFPPYYHKEPFFTIQPILNTRKKQFQMWQDLILQYCRYYKIYELDINESIKSNSVLFNNEKINRKLSREALKSIIDDIIENGFAEWVDKEKEKEKEKDKDNNNNNRVLIMWRKPDEWASLIYKWVADCGLLNTVLTVWEIQNGDDSKKQEFHQLNTTILMKSLKVLEKQSKCQTFSQDENVGVKFFSI", "length": 194 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6NWF4-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "vps25", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSFEWPWQYNFPPFFTLQPNVDTRQKQLAAWCSLVLSYCRHRKLYTLDVLEAQESPVFNNKKIERKLSVEAIQVVFEELRKKGNLEWLDKNKSRCLIMWRRPEEWGKLIYQWVSKNGMVNSVFTLYELANGDDTEKEEFHGLEDWMLLRSLQALQTDGKAEIITMDDGKGVKFF", "length": 174 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7JXV9-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Vps25", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAEFQWPWEYTFPPFFTLQPHEETRQQQLKVWTDLFLKYLRHTNRFTLSIGDQNSPLFHNEALKRRLSPELVLAILGELERSGHANPLDKRRQEWQVYWFTLEEYGNMVYDWVQETGQTNTICTLYEIASGENTSHLDFYGVDEAVLLSALRLLEEKGRCELIEMDGSHGVKFF", "length": 174 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8VZC9-1", "protein_name": "Vacuolar protein sorting-associated protein 25", "gene_name": "VPS25", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MQKLADFKLPQFFNYPPYFTLQPVRDTREKQIQLWKELILDYCKSQKIFLIGVEEDFPLFSNSAIDRSLSHEARETFLSAIVGEGRAEWLDKGHRKCLILWHRIQDWADIVLQFVRDNGLEDSVMTVEEIRSGTESLGTELQGIDRTILMRALKLLENKGKLALFKGTSADDEGVKFSV", "length": 179 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BRG1-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "VPS25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 176 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQ80-1", "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Vps25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTSGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF", "length": 176 }, "evidence": [ { "id": "Q5E9A6", "url": "https://omabrowser.org/oma/group/Q5E9A6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "ESCRT II complex", "id": "GO:0000814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000814", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043328", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "multivesicular body sorting pathway", "id": "GO:0071985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071985", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A6", "url": "https://www.uniprot.org/uniprotkb/Q5E9A6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9A6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9A6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9A6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9A9-1", "uniprot_ac": "Q5E9A9", "uniprot_id": "DDA1_BOVIN", "mass": { "chemical_mass": 11835.0, "monoisotopic_mass": 11835.0 }, "refseq": { "ac": "NP_001015583", "name": "DET1- and DDB1-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583" }, "gene_names": [ { "name": "DDA1", "type": "recommended", "evidence": [ { "id": "Q5E9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ] }, { "name": "DDA1", "type": "synonym", "evidence": [ { "id": "NP_001015583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583" } ] }, { "name": "PCIA1", "type": "synonym", "evidence": [ { "id": "NP_001015583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583" } ] } ], "protein_names": [ { "name": "DET1- and DDB1-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9/entry#names_and_taxonomy" } ] }, { "name": "DET1- and DDB1-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583" } ] }, { "name": "cross-immune reaction antigen PCIA1", "type": "synonym", "evidence": [ { "id": "NP_001015583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583" } ] } ], "function": [ { "annotation": "Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9#function" }, { "database": "UniProtKB", "id": "Q9BW61", "url": "https://www.uniprot.org/uniprotkb/Q9BW61#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDA1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9", "locus": { "chromosome": "7", "start_pos": 5807201, "end_pos": 5817259, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017068", "url": "https://www.ensembl.org/id/ENSBTAG00000017068" } ] } } ], "crossref": [ { "id": "Q5E9A9", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9A9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017068", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017068", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512898", "url": "https://www.ncbi.nlm.nih.gov/gene/512898", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512898", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512898", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HANCLCK", "url": "https://omabrowser.org/oma/group/HANCLCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9A9", "url": "https://www.orthodb.org/?gene=Q5E9A9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31879", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31879", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31879:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31879:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015583", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9A9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT", "length": 102, "header": "sp|Q5E9A9-1|DDA1_BOVIN Isoform 1 of DET1- and DDB1-associated protein 1 OS=Bos taurus OX=9913 GN=DDA1 PE=3 SV=1 CANONICAL=Q5E9A9-1" }, "isoforms": [ { "isoform_ac": "Q5E9A9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9/entry#Q5E9A9-1", "sequence": { "sequence": "MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT", "length": 102, "header": "sp|Q5E9A9-1|DDA1_BOVIN Isoform 1 of DET1- and DDB1-associated protein 1 OS=Bos taurus OX=9913 GN=DDA1 PE=3 SV=1 CANONICAL=Q5E9A9-1" }, "locus": { "chromosome": "7", "start_pos": 5817146, "end_pos": 5807792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022696.2", "url": "https://www.ensembl.org/id/ENSBTAT00000022696.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022696.1", "url": "https://www.ensembl.org/id/ENSBTAP00000022696.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 33, "end_pos": 33, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "site_lbl": "Ser33" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "site_lbl": "Ser95" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512898", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512898", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UHC4-1", "protein_name": "DET1- and DDB1-associated protein 1", "gene_name": "DDA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVDLEGESSAPPRKVARTDSPDMHEDT", "length": 102 }, "evidence": [ { "id": "Q5E9A9", "url": "https://omabrowser.org/oma/group/Q5E9A9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BW61-1", "protein_name": "DET1- and DDB1-associated protein 1", "gene_name": "DDA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT", "length": 102 }, "evidence": [ { "id": "Q5E9A9", "url": "https://omabrowser.org/oma/group/Q5E9A9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9Z5-1", "protein_name": "DET1- and DDB1-associated protein 1", "gene_name": "Dda1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVEAEGESSAPPRKVARTDSPDMPEDT", "length": 102 }, "evidence": [ { "id": "Q5E9A9", "url": "https://omabrowser.org/oma/group/Q5E9A9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "evidence": [ { "database": "UniProtKB", "id": "Q5E9A9", "url": "https://www.uniprot.org/uniprotkb/Q5E9A9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9A9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 102, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9A9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9A9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 33, 95 ], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 15, "end_pos": 17 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9C0-1", "uniprot_ac": "Q5E9C0", "uniprot_id": "RSU1_BOVIN", "mass": { "chemical_mass": 31537.0, "monoisotopic_mass": 31537.0 }, "refseq": { "ac": "NP_001035691", "name": "ras suppressor protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035691" }, "gene_names": [ { "name": "RSU1", "type": "recommended", "evidence": [ { "id": "Q5E9C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ] }, { "name": "RSU1", "type": "synonym", "evidence": [ { "id": "NP_001035691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035691" } ] } ], "protein_names": [ { "name": "Ras suppressor protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#names_and_taxonomy" } ] }, { "name": "Rsu-1", "type": "synonym", "evidence": [ { "id": "Q5E9C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#names_and_taxonomy" } ] }, { "name": "ras suppressor protein 1", "type": "synonym", "evidence": [ { "id": "NP_001035691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035691" } ] }, { "name": "rsu-1", "type": "synonym", "evidence": [ { "id": "NP_001035691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035691" } ] } ], "function": [ { "annotation": "Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ8#function" }, { "database": "UniProtKB", "id": "ARBA00053823", "url": "https://www.uniprot.org/uniprotkb/ARBA00053823#function" }, { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0#function" }, { "database": "UniProtKB", "id": "A0AAA9SGA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA1#function" }, { "database": "UniProtKB", "id": "A0A3Q1M5B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5B4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSU1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0", "locus": { "chromosome": "13", "start_pos": 31063740, "end_pos": 31271118, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027446", "url": "https://www.ensembl.org/id/ENSBTAG00000027446" } ] } } ], "crossref": [ { "id": "Q5E9C0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9C0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027446", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617534", "url": "https://www.ncbi.nlm.nih.gov/gene/617534", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617534", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617534", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RHMQGGR", "url": "https://omabrowser.org/oma/group/RHMQGGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5B4", "url": "https://www.orthodb.org/?gene=A0A3Q1M5B4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9C0", "url": "https://www.orthodb.org/?gene=Q5E9C0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035691", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5B4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5B4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2V1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2V1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFTLSHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 277, "header": "sp|Q5E9C0-1|RSU1_BOVIN Isoform 1 of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=2 SV=1 CANONICAL=Q5E9C0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5B4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#A0A3Q1M5B4-1", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFSSFSHLKGKQNVVSVSTAVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 278, "header": "tr|A0A3Q1M5B4-1|A0A3Q1M5B4_BOVIN Computationally mapped isoform of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=4 SV=1 CANONICAL=Q5E9C0-1" }, "locus": { "chromosome": "13", "start_pos": 31270752, "end_pos": 31064212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075562.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075562.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068837.1" } ] } }, { "isoform_ac": "A0AAA9SGA1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#A0AAA9SGA1-1", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFTLSHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYPHSLPVGTFSLSVNVFKCMDVRVGRRLSVEELMLLNCGVGEDS", "length": 287, "header": "tr|A0AAA9SGA1-1|A0AAA9SGA1_BOVIN Computationally mapped isoform of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=4 SV=1 CANONICAL=Q5E9C0-1" }, "locus": { "chromosome": "13", "start_pos": 31270752, "end_pos": 31153980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099758.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099758.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082699.1" } ] } }, { "isoform_ac": "A0AAF6ZDZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#A0AAF6ZDZ8-1", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFTLSHITQLVLSHNKLTSESTIAVLCSQFLTSVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 291, "header": "tr|A0AAF6ZDZ8-1|A0AAF6ZDZ8_BOVIN Computationally mapped isoform of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=4 SV=1 CANONICAL=Q5E9C0-1" }, "locus": { "chromosome": "13", "start_pos": 31270752, "end_pos": 31064212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039415.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039415.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039209.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039209.4" } ] } }, { "isoform_ac": "A0ABI0P2V1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#A0ABI0P2V1-1", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLSVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 260, "header": "tr|A0ABI0P2V1-1|A0ABI0P2V1_BOVIN Computationally mapped isoform of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=4 SV=1 CANONICAL=Q5E9C0-1" }, "locus": { "chromosome": "13", "start_pos": 31270752, "end_pos": 31064212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141511.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141511.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105853.1" } ] } }, { "isoform_ac": "Q5E9C0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0/entry#Q5E9C0-1", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFTLSHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 277, "header": "sp|Q5E9C0-1|RSU1_BOVIN Isoform 1 of Ras suppressor protein 1 OS=Bos taurus OX=9913 GN=RSU1 PE=2 SV=1 CANONICAL=Q5E9C0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:617534", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617534", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IKD0-1", "protein_name": "Ras suppressor protein 1", "gene_name": "rsu1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKSLKKIVEESRDKNLPEVDMCDRGISNLLDIPGLFSLSSITQLVLSHNKLSAVPPNIADLKNLEVLNMFNNQIEELPTQISSLQKLKHLNLGMNRLSTLPRGFGSLPALEVLDLTYNNLNESSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLAKLQILSLRDNDLISLPREIGDLTQLKELHIQGNRLTVLPPELGNLDLTGPKQVFKAENNSWVTPIADQFQLGISHVFEYIRSETYKYLYGRHMQANPEAPKKNADKSKKISRKPLAAKNK", "length": 277 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8I5ZQM5-1", "protein_name": "Ras suppressor protein 1", "gene_name": "Rsu1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISSMLDVNGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 277 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XHI1-1", "protein_name": "Ras suppressor protein 1", "gene_name": "RSU1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSKSLKKIVEESREKNQPEVDMCDRGISNMLDVPGLFTLSHITQLVLSHNKLTTVPANIADLRNIEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELVFMADTCRRTLNLRRRTMTSQRRSVVSLWQPGTNKSPACASGFISSTFLLHVPIIFQHICYYIVRKPRLEVKAIYCVCCFRGYCLRNTKLHTLLITVTFM", "length": 299 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RW98-1", "protein_name": "Ras suppressor protein 1", "gene_name": "RSU1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLTAKNK", "length": 277 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HN65-1", "protein_name": "Ras suppressor protein 1", "gene_name": "Rsu1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNK", "length": 277 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q15404-1", "protein_name": "Ras suppressor protein 1", "gene_name": "RSU1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR", "length": 277 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54EG0-1", "protein_name": "Ras suppressor protein 1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGASLSKEIDKLREKKVTELELIDKGIDDLPNNIGTIETLKKLNLSKNNLKRLPPAIGNLKNLTLLNLFNNSLRELPHEITQLVNLESMNLSINKLKALPRGFGSFNHLFFLDVSYNSITELTTQIGLISTLKELHISFNELTELPVELSRCSELEVINASHNKILELPSEFSKLPKLKLLNITGNKLSFIPPDYGQLTKIEKIDFSKNPDIHKSLDQHAIRGPEVLIKYLKSDEYQSIYYSETKKPRPSGLTSSTENTTIPQNTTTTTTTTSKPEEEESSVPYH", "length": 285 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9V428-1", "protein_name": "Ras suppressor protein 1", "gene_name": "ics", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSQSCIPVSAKMSKAKKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVLPPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPPKADKSKKASRIRA", "length": 283 }, "evidence": [ { "id": "Q5E9C0", "url": "https://omabrowser.org/oma/group/Q5E9C0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C0", "url": "https://www.uniprot.org/uniprotkb/Q5E9C0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9C0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 277, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9C0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9C0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9E6-1", "uniprot_ac": "Q5E9E6", "uniprot_id": "RL10A_BOVIN", "mass": { "chemical_mass": 24831.0, "monoisotopic_mass": 24831.0 }, "refseq": { "ac": "NP_001015647", "name": "large ribosomal subunit protein uL1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015647" }, "gene_names": [ { "name": "RPL10A", "type": "recommended", "evidence": [ { "id": "Q5E9E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ] }, { "name": "RPL10A", "type": "synonym", "evidence": [ { "id": "NP_001015647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015647" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL1", "type": "recommended", "evidence": [ { "id": "Q5E9E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L10a", "type": "synonym", "evidence": [ { "id": "NP_001015647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015647" }, { "id": "Q5E9E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL1", "type": "synonym", "evidence": [ { "id": "NP_001015647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015647" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6#function" }, { "database": "UniProtKB", "id": "P62906", "url": "https://www.uniprot.org/uniprotkb/P62906#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL10A", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6", "locus": { "chromosome": "23", "start_pos": 9428500, "end_pos": 9425859, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019494", "url": "https://www.ensembl.org/id/ENSBTAG00000019494" } ] } } ], "crossref": [ { "id": "Q5E9E6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9E6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019494", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019494", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00403", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00403", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533310", "url": "https://www.ncbi.nlm.nih.gov/gene/533310", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533310", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533310", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPRNKMP", "url": "https://omabrowser.org/oma/group/GPRNKMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9E6", "url": "https://www.orthodb.org/?gene=Q5E9E6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00687", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00687", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015647", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217, "header": "sp|Q5E9E6-1|RL10A_BOVIN Isoform 1 of Large ribosomal subunit protein uL1 OS=Bos taurus OX=9913 GN=RPL10A PE=2 SV=3 CANONICAL=Q5E9E6-1" }, "isoforms": [ { "isoform_ac": "Q5E9E6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6/entry#Q5E9E6-1", "sequence": { "sequence": "MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217, "header": "sp|Q5E9E6-1|RL10A_BOVIN Isoform 1 of Large ribosomal subunit protein uL1 OS=Bos taurus OX=9913 GN=RPL10A PE=2 SV=3 CANONICAL=Q5E9E6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "site_lbl": "Tyr11" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533310", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533310", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T0H0-1", "protein_name": "Ribosomal protein", "gene_name": "RPL10A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F6SU35-1", "protein_name": "Ribosomal protein", "gene_name": "RPL10A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSKVSRDTLYEAVKEVLQGSKTKKRKFVETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCLLGDQQHCDEAKAVEIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENLVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTEDELVYNIHLAINFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P0CX43-1", "protein_name": "Large ribosomal subunit protein uL1A", "gene_name": "RPL1A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX44-1", "protein_name": "Large ribosomal subunit protein uL1B", "gene_name": "RPL1B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P62906-1", "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "RPL10A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62907-1", "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "Rpl10a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86L05-1", "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "rpl10a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKISSDQVRSIVSQLFKEAQESKRGFLETVELQINLKNYDTKKDKRFSGQIKIGTVTKPKLSVCVFADQQHCDEATKIGAEFMDIEALKKIGPKNKKAIKKLSKKYDAFLASESILRQVPKLLGPGLNKVGKFPTLLTHSEDMASKINDVKSTVKFQLKKVLCLAVAVGHIELTEREVATNIIQSINFLVSLLKKGWQNIKTLYVKTSMGPSHRVY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VZB9-1", "protein_name": "Large ribosomal subunit protein uL1z", "gene_name": "RPL10AA", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSKLQSEAVREAITTITGKSEAKKRNFVETIELQIGLKNYDPQKDKRFSGSVKLPHIPRPKMKICMLGDAQHVEEAEKMGLENMDVESLKKLNKNKKLVKKLAKKYHAFLASESVIKQIPRLLGPGLNKAGKFPTLVSHQESLESKVNETKATVKFQLKKVLCMGVAVGNLSMEEKQIFQNVQMSVNFLVSLLKKNWQNVRCLYLKSTMGPPQRIF", "length": 216 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VTP4-1", "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "RpL10Ab", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASKVSRDTLYEGVNGLLEASAKKKRGFLETVELQIGLKNYDPQKDKRFSGTVKLKHIPRPKMKVCILGDQQHCDEAKANNVDFMDAEALKKLNKNKKLVKKLAKSYDAFLASESLIKQIPRLLGPGLNKAGKFPALLSHQESMIGKIEEVKSTIKFQMKKVLCLSVAVGHVGMKSDELAQNVNLSINFLVSLLKKNWQNVRSLHVKSSMGPPQRLY", "length": 217 }, "evidence": [ { "id": "Q5E9E6", "url": "https://omabrowser.org/oma/group/Q5E9E6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E6", "url": "https://www.uniprot.org/uniprotkb/Q5E9E6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9E6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9E6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9E6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9E7-1", "uniprot_ac": "Q5E9E7", "uniprot_id": "GL8D1_BOVIN", "mass": { "chemical_mass": 41958.0, "monoisotopic_mass": 41958.0 }, "refseq": { "ac": "NP_001015579", "name": "glycosyltransferase 8 domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015579" }, "gene_names": [ { "name": "GLT8D1", "type": "recommended", "evidence": [ { "id": "Q5E9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ] }, { "name": "GLT8D1", "type": "synonym", "evidence": [ { "id": "NP_001015579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015579" } ] } ], "protein_names": [ { "name": "Glycosyltransferase 8 domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "Q5E9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7/entry#names_and_taxonomy" } ] }, { "name": "glycosyltransferase 8 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015579" } ] } ], "function": [ { "annotation": "In vitro, catalyzes the transfer of a galactose residue from UDP-galactose onto GalNAc and GlcNAc structures.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7#function" }, { "database": "UniProtKB", "id": "Q68CQ7", "url": "https://www.uniprot.org/uniprotkb/Q68CQ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLT8D1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7", "locus": { "chromosome": "22", "start_pos": 48169414, "end_pos": 48156485, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014550", "url": "https://www.ensembl.org/id/ENSBTAG00000014550" } ] } } ], "crossref": [ { "id": "Q5E9E7", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014550", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014550", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06429", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06429", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512192", "url": "https://www.ncbi.nlm.nih.gov/gene/512192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512192", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512192", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YKQHSNI", "url": "https://omabrowser.org/oma/group/YKQHSNI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9E7", "url": "https://www.orthodb.org/?gene=Q5E9E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13778", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13778", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13778:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13778:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFRKVNIVILVLAVALFLLVLHHNFLGLSSLLRNEVSDSGIVGLQPVDFIPNAPQRVVDGREEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNGTADHLRSWLSSSNLKRIRYKIVNFDTKLLEGKVKEDPDQGESIKPLTFARFYLPILVPRAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSTSAKVVIRGAGNQYNYIGYLDYKKERIRELSMKASTCSFNPGVFVANLTEWRRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYTDVWEKWYIPDPTGKFSLIRRHVEISNTK", "length": 371, "header": "sp|Q5E9E7-1|GL8D1_BOVIN Isoform 1 of Glycosyltransferase 8 domain-containing protein 1 OS=Bos taurus OX=9913 GN=GLT8D1 PE=2 SV=1 CANONICAL=Q5E9E7-1" }, "isoforms": [ { "isoform_ac": "Q5E9E7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7/entry#Q5E9E7-1", "sequence": { "sequence": "MSFRKVNIVILVLAVALFLLVLHHNFLGLSSLLRNEVSDSGIVGLQPVDFIPNAPQRVVDGREEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNGTADHLRSWLSSSNLKRIRYKIVNFDTKLLEGKVKEDPDQGESIKPLTFARFYLPILVPRAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSTSAKVVIRGAGNQYNYIGYLDYKKERIRELSMKASTCSFNPGVFVANLTEWRRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYTDVWEKWYIPDPTGKFSLIRRHVEISNTK", "length": 371, "header": "sp|Q5E9E7-1|GL8D1_BOVIN Isoform 1 of Glycosyltransferase 8 domain-containing protein 1 OS=Bos taurus OX=9913 GN=GLT8D1 PE=2 SV=1 CANONICAL=Q5E9E7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 103, "start_aa": "Asn", "end_pos": 103, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn103", "evidence": [ { "id": "Q5E9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 257, "start_aa": "Asn", "end_pos": 257, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "Q5E9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512192", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512192", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AET2-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "GLT8D1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTLRKVNISILVAAVVIFLLVLHHNFLGLSDLLKRELTDSNPLGLQPIDFIPAAPQRLTDERNDREISVVIAASDERLGGAIAAMNSIYRNTRSNVVFYIVTLNDTVDHLRLWLRNTALKNLRYHILNFDPRVLEGKVQVDPQKADSIKPLTFARFYLPNLVPHAEKAIYVDDDIIVQDDILELYNTPLKPGHAAAFSDDCDSTTNKVAVRGAGNQYNYIGFLDYKKETIRKLAMKANTCSFNPGVFVANLTEWKLQNITKQLEKWMTLNVAEELYSRTLSGSITTPPLLIVFYKQHSSIDPLWNVRHLGSNAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYAEVWEKWYVPDPTGKFSLIRRHPEAYEAK", "length": 372 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7F1L5-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "Glt8d1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSFRKVSIIIWVLAIVLFLLVLHHNFLSLSSLLRNEVSDSGILGLQPIDFVADIHQHPVNGRQEEIPVVIAASEDRLGGTIAAINSIHHNTRSNVIFYIVTLNSTEDHLRSWLNSVSLKSIRYKIVNFDTKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSTSTKVIIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRAASYADVWEKWYIPDPTGKFSLIRRHMDTSNIK", "length": 371 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SH98-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "GLT8D1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSFRKVNIIILVVAVALFLLVLHHNFLSLNSLLRNEVSDSGIVGLQPIDFIPNAPQHAVDGRQEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNGTADHLRSWLSSSTLKSIRYKIVNFDSKLLEGKVKEDPDQGESIKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKVVIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYTDIWEKWYIPDPTGKFSLIRRHVEISNIK", "length": 371 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q0V7R1-1", "protein_name": "Probable galacturonosyltransferase-like 3", "gene_name": "GATL3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSLRLRLCLLLLLPITISCVTVTLTDLPAFREAPAFRNGRECSKTTWIPSDHEHNPSIIHIAMTLDAIYLRGSVAGVFSVLQHASCPENIVFHFIATHRRSADLRRIISSTFPYLTYHIYHFDPNLVRSKISSSIRRALDQPLNYARIYLADLLPIAVRRVIYFDSDLVVVDDVAKLWRIDLRRHVVGAPEYCHANFTNYFTSRFWSSQGYKSALKDRKPCYFNTGVMVIDLGKWRERRVTVKLETWMRIQKRHRIYELGSLPPFLLVFAGDVEPVEHRWNQHGLGGDNLEGLCRNLHPGPVSLLHWSGKGKPWLRLDSRRPCPLDSLWAPYDLFRYSPLISDS", "length": 345 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q68CQ7-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "GLT8D1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFRKVNIIILVLAVALFLLVLHHNFLSLSSLLRNEVTDSGIVGPQPIDFVPNALRHAVDGRQEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNNTADHLRSWLNSDSLKSIRYKIVNFDPKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTALKPGHAAAFSEDCDSASTKVVIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHLKPWGRTASYTDVWEKWYIPDPTGKFNLIRRYTEISNIK", "length": 371 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NSU3-1", "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "Glt8d1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFRKVNIIIWVLAVVLFLLVLHHNFLSLSSLLKNDISDSGIVGLQPIDFVASAHQHPVSERQEEIPVVIAASEDRLGGTIAAINSVHQNTRSNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKVIIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYADVWEKWYIPDPTGKFSLIRRHMDTSNIK", "length": 371 }, "evidence": [ { "id": "Q5E9E7", "url": "https://omabrowser.org/oma/group/Q5E9E7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E7", "url": "https://www.uniprot.org/uniprotkb/Q5E9E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9E7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 371, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9E7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9E7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 103, 257 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 257, "end_pos": 259 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9G6-1", "uniprot_ac": "Q5E9G6", "uniprot_id": "FBX8_BOVIN", "mass": { "chemical_mass": 37017.0, "monoisotopic_mass": 37017.0 }, "refseq": { "ac": "NP_001015667", "name": "F-box only protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015667" }, "gene_names": [ { "name": "FBXO8", "type": "recommended", "evidence": [ { "id": "Q5E9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ] }, { "name": "FBXO8", "type": "synonym", "evidence": [ { "id": "NP_001015667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015667" } ] } ], "protein_names": [ { "name": "F-box only protein 8", "type": "recommended", "evidence": [ { "id": "Q5E9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 8", "type": "synonym", "evidence": [ { "id": "NP_001015667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015667" } ] } ], "function": [ { "annotation": "May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO8", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6", "locus": { "chromosome": "8", "start_pos": 6555902, "end_pos": 6595352, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006715", "url": "https://www.ensembl.org/id/ENSBTAG00000006715" } ] } } ], "crossref": [ { "id": "Q5E9G6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9G6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006715", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006715", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22088", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22088", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538528", "url": "https://www.ncbi.nlm.nih.gov/gene/538528", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538528", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538528", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NANPHEG", "url": "https://omabrowser.org/oma/group/NANPHEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9G6", "url": "https://www.orthodb.org/?gene=Q5E9G6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663:SF372", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF372", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01369", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01369", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015667", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9G6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQGLWRVARNQQLQQEGYGEQGYLSREQSRRVAASNMSHTSHRKHVQGGIDIYHLLKTRKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319, "header": "sp|Q5E9G6-1|FBX8_BOVIN Isoform 1 of F-box only protein 8 OS=Bos taurus OX=9913 GN=FBXO8 PE=2 SV=1 CANONICAL=Q5E9G6-1" }, "isoforms": [ { "isoform_ac": "Q5E9G6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6/entry#Q5E9G6-1", "sequence": { "sequence": "MGQGLWRVARNQQLQQEGYGEQGYLSREQSRRVAASNMSHTSHRKHVQGGIDIYHLLKTRKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319, "header": "sp|Q5E9G6-1|FBX8_BOVIN Isoform 1 of F-box only protein 8 OS=Bos taurus OX=9913 GN=FBXO8 PE=2 SV=1 CANONICAL=Q5E9G6-1" }, "locus": { "chromosome": "8", "start_pos": 6579206, "end_pos": 6556348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008831.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008831.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008831.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008831.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538528", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538528", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RJ03-1", "protein_name": "F-box only protein 8", "gene_name": "FBXO8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQGLWRVVRNQQLQQEGYSEQGYLSREQSRRMAASSISNTSHRKQVQGGIDIYHLLKTRKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319 }, "evidence": [ { "id": "Q5E9G6", "url": "https://omabrowser.org/oma/group/Q5E9G6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HZR9-1", "protein_name": "F-box only protein 8", "gene_name": "Fbxo8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGQGLWRVARNQHLQQEAYSEPGYLSREQSRRVTSSNISHSSHRKQAQGGIDLYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPEEGVSYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319 }, "evidence": [ { "id": "Q5E9G6", "url": "https://omabrowser.org/oma/group/Q5E9G6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5M7U1-1", "protein_name": "F-box only protein 8", "gene_name": "Fbxo8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQGLWRVARNQHLQQEAYGETGYLSREQSRRVASSNISHTSHRKQAQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPEEGVSYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319 }, "evidence": [ { "id": "Q5E9G6", "url": "https://omabrowser.org/oma/group/Q5E9G6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NRD0-1", "protein_name": "F-box only protein 8", "gene_name": "FBXO8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319 }, "evidence": [ { "id": "Q5E9G6", "url": "https://omabrowser.org/oma/group/Q5E9G6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZN3-1", "protein_name": "F-box only protein 8", "gene_name": "Fbxo8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQGLWRVARNHHLQQEAYSETGYLSREQSRRVASSNISHTSHRKQAQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPEEGVSYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA", "length": 319 }, "evidence": [ { "id": "Q5E9G6", "url": "https://omabrowser.org/oma/group/Q5E9G6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "pmid": "" }, { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G6", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9G6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9G6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9G6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 68, "end_pos": 111, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G6" }, { "id": "PRU00189", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00189" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEC7", "eco_id": "ECO_0000255", "start_pos": 146, "end_pos": 276, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9H1-1", "uniprot_ac": "Q5E9H1", "uniprot_id": "FIBIN_BOVIN", "mass": { "chemical_mass": 24233.0, "monoisotopic_mass": 24233.0 }, "refseq": { "ac": "NP_001015541", "name": "fin bud initiation factor homolog precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015541" }, "gene_names": [ { "name": "FIBIN", "type": "recommended", "evidence": [ { "id": "Q5E9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ] }, { "name": "FIBIN", "type": "synonym", "evidence": [ { "id": "NP_001015541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015541" } ] } ], "protein_names": [ { "name": "Fin bud initiation factor homolog", "type": "recommended", "evidence": [ { "id": "Q5E9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1/entry#names_and_taxonomy" } ] }, { "name": "fin bud initiation factor homolog precursor", "type": "synonym", "evidence": [ { "id": "NP_001015541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015541" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FIBIN", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1", "locus": { "chromosome": "15", "start_pos": 57706352, "end_pos": 57704075, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056510", "url": "https://www.ensembl.org/id/ENSBTAG00000056510" } ] } } ], "crossref": [ { "id": "Q5E9H1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9H1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006676", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006676", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507975", "url": "https://www.ncbi.nlm.nih.gov/gene/507975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507975", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CHGYFDG", "url": "https://omabrowser.org/oma/group/CHGYFDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9H1", "url": "https://www.orthodb.org/?gene=Q5E9H1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31185:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31185:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15819", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15819", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9H1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVFLKFLWMGFLCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSSASTLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV", "length": 211, "header": "sp|Q5E9H1-1|FIBIN_BOVIN Isoform 1 of Fin bud initiation factor homolog OS=Bos taurus OX=9913 GN=FIBIN PE=2 SV=1 CANONICAL=Q5E9H1-1" }, "isoforms": [ { "isoform_ac": "Q5E9H1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1/entry#Q5E9H1-1", "sequence": { "sequence": "MVFLKFLWMGFLCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSSASTLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV", "length": 211, "header": "sp|Q5E9H1-1|FIBIN_BOVIN Isoform 1 of Fin bud initiation factor homolog OS=Bos taurus OX=9913 GN=FIBIN PE=2 SV=1 CANONICAL=Q5E9H1-1" }, "locus": { "chromosome": "15", "start_pos": 57705348, "end_pos": 57704274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105530.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105530.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078495.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078495.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 30, "start_aa": "Asn", "end_pos": 30, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn30", "evidence": [ { "id": "Q5E9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507975", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507975", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1IGX5-1", "protein_name": "Fin bud initiation factor", "gene_name": "fibin", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGTMASPLFILIACLLSMRVGGAFFAGPLYPEMSNGTFHHYFVPDGYYEENDDPEKCQMLFKMMDNRKCTLDEDQDSVIRDDFTIIKRHIEDAARVLEGIGKSISFDLDGEDSYGKYLRRETTQISEAFSNSEKSLLELEVKFKQSQENELKEEHKISDDFLNMIVHTRDVLKETLDISLGLKDKHELLSLIIRSHGTRLSRLKNDYMKV", "length": 210 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BX99-1", "protein_name": "Fin bud initiation factor homolog (zebrafish)", "gene_name": "FIBIN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPALRLLWFGCLCSLCRGYFEGPLYPEMSNGTLHHYFVPDGDYEENDDPERCQLLFRVSEQRRCGTAAAGEGLSLREELTVLGRQVEDAGRVLEGIGKSISYDLDGEESYSTYLRRESAQISDAYSSSDRSLSELEGKFRQGQEQGGREEARLGDSFLGLLLHARALLRETRAISSGLRDKHDLLSLTVRSHGARLSRLKNDYLRA", "length": 206 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HSR8-1", "protein_name": "Fin bud initiation factor homolog", "gene_name": "Fibin", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVIPKLIWMGFFCHLCRGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDRRRCSQGEGGQASSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKSGYLEGGGQRTG", "length": 217 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L9M3-1", "protein_name": "Fin bud initiation factor homolog", "gene_name": "FIBIN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVFLKFLWMGFLCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSPASSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV", "length": 211 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5U2T4-1", "protein_name": "Fin bud initiation factor homolog", "gene_name": "Fibin", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMFTKLIWMGFFCHLCRGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDRRRCSQGEGGQASSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLGISVGLRDKYELLAHTIRSHGTRLGRLKSDYLEGGGQKMG", "length": 217 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TAL6-1", "protein_name": "Fin bud initiation factor homolog", "gene_name": "FIBIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVFLKFFCMSFFCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSQVGSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV", "length": 211 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQS3-1", "protein_name": "Fin bud initiation factor homolog", "gene_name": "Fibin", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVFPKLIWMGFFCHLCRGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDRRRCSQGEGGQASSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLAHTIRSHGTRLGRLKSDYLEGGAQKTG", "length": 217 }, "evidence": [ { "id": "Q5E9H1", "url": "https://omabrowser.org/oma/group/Q5E9H1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9H1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9H1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9H1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 30 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9H2-1", "uniprot_ac": "Q5E9H2", "uniprot_id": "1A1L1_BOVIN", "mass": { "chemical_mass": 57066.0, "monoisotopic_mass": 57066.0 }, "refseq": { "ac": "NP_001015526", "name": "1-aminocyclopropane-1-carboxylate synthase-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526" }, "gene_names": [ { "name": "ACCS", "type": "recommended", "evidence": [ { "id": "Q5E9H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ] }, { "name": "ACCS", "type": "synonym", "evidence": [ { "id": "NP_001015526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526" } ] }, { "name": "ACS", "type": "synonym", "evidence": [ { "id": "NP_001015526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526" } ] } ], "protein_names": [ { "name": "1-aminocyclopropane-1-carboxylate synthase-like protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2/entry#names_and_taxonomy" } ] }, { "name": "1-aminocyclopropane-1-carboxylate synthase-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526" } ] }, { "name": "ACC synthase-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526" }, { "id": "Q5E9H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2#function" }, { "database": "UniProtKB", "id": "Q96QU6", "url": "https://www.uniprot.org/uniprotkb/Q96QU6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACCS", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2", "locus": { "chromosome": "15", "start_pos": 74196856, "end_pos": 74177644, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008465", "url": "https://www.ensembl.org/id/ENSBTAG00000008465" } ] } } ], "crossref": [ { "id": "Q5E9H2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9H2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505649", "url": "https://www.ncbi.nlm.nih.gov/gene/505649", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505649", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505649", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9H2", "url": "https://www.orthodb.org/?gene=Q5E9H2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43795", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43795", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43795:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43795:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015526", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9H2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFTLPQKEFRMTTACPGSDSIQDLPSNKGDGLERECSRKPDQKLLKFYGVGDPAAELSSSSPYLSSRGSVIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINLGTSENKLCFDLLSRRLSQSDMLQVEPALLQYPDWRGHLFLREEVARFLSFYCRSPAPLKPENVVVLNGCASLFSALATVLCEAGEAFLIPAPYYGAITQHVYLYGNVRLVCVYLDSEVTGLETRPFQLTVEKLEMALQGANSEGVKVKGLILINPQNPLGDIYSPGELQEYLEFAKRHELHVMVDEVYMLSVFEESAGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENWAVATAVASLCRYHGLSGLVQYQMAQLLRDHDWINQVYLPENHARLKAAHTYVSEDLRALGIPFVSRGAGFFIWVDLRKYLPEATFEEEVLLWRRFLENKVLLSFGKAFECKEPGWFRLVFSDKTHRLHLGMQRVRQVLEGQPQLADGAPPHQIQEPQGPHR", "length": 502, "header": "sp|Q5E9H2-1|1A1L1_BOVIN Isoform 1 of 1-aminocyclopropane-1-carboxylate synthase-like protein 1 OS=Bos taurus OX=9913 GN=ACCS PE=2 SV=1 CANONICAL=Q5E9H2-1" }, "isoforms": [ { "isoform_ac": "Q5E9H2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2/entry#Q5E9H2-1", "sequence": { "sequence": "MFTLPQKEFRMTTACPGSDSIQDLPSNKGDGLERECSRKPDQKLLKFYGVGDPAAELSSSSPYLSSRGSVIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINLGTSENKLCFDLLSRRLSQSDMLQVEPALLQYPDWRGHLFLREEVARFLSFYCRSPAPLKPENVVVLNGCASLFSALATVLCEAGEAFLIPAPYYGAITQHVYLYGNVRLVCVYLDSEVTGLETRPFQLTVEKLEMALQGANSEGVKVKGLILINPQNPLGDIYSPGELQEYLEFAKRHELHVMVDEVYMLSVFEESAGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENWAVATAVASLCRYHGLSGLVQYQMAQLLRDHDWINQVYLPENHARLKAAHTYVSEDLRALGIPFVSRGAGFFIWVDLRKYLPEATFEEEVLLWRRFLENKVLLSFGKAFECKEPGWFRLVFSDKTHRLHLGMQRVRQVLEGQPQLADGAPPHQIQEPQGPHR", "length": 502, "header": "sp|Q5E9H2-1|1A1L1_BOVIN Isoform 1 of 1-aminocyclopropane-1-carboxylate synthase-like protein 1 OS=Bos taurus OX=9913 GN=ACCS PE=2 SV=1 CANONICAL=Q5E9H2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505649", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505649", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ], "pmid": "" }, { "name": "transaminase activity", "id": "GO:0008483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008483", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H2", "url": "https://www.uniprot.org/uniprotkb/Q5E9H2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9H2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 502, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9H2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9H2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9H8-1", "uniprot_ac": "Q5E9H8", "uniprot_id": "GP173_BOVIN", "mass": { "chemical_mass": 41479.0, "monoisotopic_mass": 41479.0 }, "refseq": { "ac": "NP_001015604", "name": "probable G-protein coupled receptor 173", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015604" }, "gene_names": [ { "name": "GPR173", "type": "recommended", "evidence": [ { "id": "Q5E9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8" } ] }, { "name": "GPR173", "type": "synonym", "evidence": [ { "id": "NP_001015604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015604" } ] } ], "protein_names": [ { "name": "Probable G protein-coupled receptor 173", "type": "recommended", "evidence": [ { "id": "Q5E9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8/entry#names_and_taxonomy" } ] }, { "name": "probable G-protein coupled receptor 173", "type": "synonym", "evidence": [ { "id": "NP_001015604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015604" } ] } ], "function": [ { "annotation": "Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8#function" }, { "database": "UniProtKB", "id": "Q9JJH2", "url": "https://www.uniprot.org/uniprotkb/Q9JJH2#function" }, { "database": "UniProtKB", "id": "Q9NS66", "url": "https://www.uniprot.org/uniprotkb/Q9NS66#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR173", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8", "locus": { "chromosome": "X", "start_pos": 90558684, "end_pos": 90531688, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017767", "url": "https://www.ensembl.org/id/ENSBTAG00000017767" } ] } } ], "crossref": [ { "id": "Q5E9H8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9H8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017767", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017767", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15217", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15217", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515148", "url": "https://www.ncbi.nlm.nih.gov/gene/515148", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515148", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515148", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KCLRTHT", "url": "https://omabrowser.org/oma/group/KCLRTHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9H8", "url": "https://www.orthodb.org/?gene=Q5E9H8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19268:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19268:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015604", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9H8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANTTGEPEEVSGALSPPSAVAYVKLVLLGLIMCVSLAGNAILSLLVLKDRALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373, "header": "sp|Q5E9H8-1|GP173_BOVIN Isoform 1 of Probable G protein-coupled receptor 173 OS=Bos taurus OX=9913 GN=GPR173 PE=2 SV=1 CANONICAL=Q5E9H8-1" }, "isoforms": [ { "isoform_ac": "Q5E9H8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8/entry#Q5E9H8-1", "sequence": { "sequence": "MANTTGEPEEVSGALSPPSAVAYVKLVLLGLIMCVSLAGNAILSLLVLKDRALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373, "header": "sp|Q5E9H8-1|GP173_BOVIN Isoform 1 of Probable G protein-coupled receptor 173 OS=Bos taurus OX=9913 GN=GPR173 PE=2 SV=1 CANONICAL=Q5E9H8-1" }, "locus": { "chromosome": "X", "start_pos": 90558401, "end_pos": 90557405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116292.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116292.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075963.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "Q5E9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 3, "start_aa": "Asn", "end_pos": 3, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn3", "evidence": [ { "id": "Q5E9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515148", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515148", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IJL0-1", "protein_name": "Probable G-protein coupled receptor 173", "gene_name": "Gpr173", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MANTTGEPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAICFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGAVPAPREPYCVM", "length": 373 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LTJ7-1", "protein_name": "Probable G-protein coupled receptor 173", "gene_name": "GPR173", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PI62-1", "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "Gpr173", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANTTGEPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAICFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9I918-1", "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "gpr173", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANGNASSDGPGNPLAAVVSTTGGVMGGAPSSAVSTYVKLVLLGLIICISLVGNLVVSLLVLRDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIKNGSAWTYSVLSCKVVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCVAVVCMVWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLILATHVVYMKLLLFEYKHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNLHNQNRRLLGMEEFKAEKQLGRMFYVITLFFLVLWSPYIVACYWRVFVKACTIPHRYLSTTVWMSFAQAGVNPIICFFLNKDLKKGLLAHLPPCCRTPPQLPREPYCVM", "length": 387 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9JJH2-1", "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "Gpr173", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANTTGEPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAICFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NS66-1", "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "GPR173", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM", "length": 373 }, "evidence": [ { "id": "Q5E9H8", "url": "https://omabrowser.org/oma/group/Q5E9H8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gonadotropin-releasing hormone receptor activity", "id": "GO:0004968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004968", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H8", "url": "https://www.uniprot.org/uniprotkb/Q5E9H8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9H8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 373, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9H8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9H8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 3, 184 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 229, "end_pos": 231 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9I1-1", "uniprot_ac": "Q5E9I1", "uniprot_id": "CCNG1_BOVIN", "mass": { "chemical_mass": 34107.0, "monoisotopic_mass": 34107.0 }, "refseq": { "ac": "NP_001013382", "name": "cyclin-G1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013382" }, "gene_names": [ { "name": "CCNG1", "type": "recommended", "evidence": [ { "id": "Q5E9I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ] }, { "name": "CCNG1", "type": "synonym", "evidence": [ { "id": "NP_001013382", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013382" } ] } ], "protein_names": [ { "name": "Cyclin-G1", "type": "recommended", "evidence": [ { "id": "Q5E9I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1/entry#names_and_taxonomy" } ] }, { "name": "cyclin-G1", "type": "synonym", "evidence": [ { "id": "NP_001013382", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013382" } ] } ], "function": [ { "annotation": "May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1#function" }, { "database": "UniProtKB", "id": "A0ABI0P6G3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6G3#function" }, { "database": "UniProtKB", "id": "ARBA00025528", "url": "https://www.uniprot.org/uniprotkb/ARBA00025528#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNG1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1", "locus": { "chromosome": "7", "start_pos": 75123209, "end_pos": 75115932, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006607", "url": "https://www.ensembl.org/id/ENSBTAG00000006607" } ] } } ], "crossref": [ { "id": "Q5E9I1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006607", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006607", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20583", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20583", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281671", "url": "https://www.ncbi.nlm.nih.gov/gene/281671", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281671", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281671", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CFEAQEE", "url": "https://omabrowser.org/oma/group/CFEAQEE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9I1", "url": "https://www.orthodb.org/?gene=Q5E9I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804757", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001013382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013382", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P6G3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6G3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEVLTTTDSQKLLHQLNALLEQELRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSTEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENVPHERKSSLNFERLEAQLKACYCRIIFSKAKPSVLALSIIALEIQAQKYIELTEGVERLQKHSKISGRDLTFWQELVSKCLAEYSSNKCAKPNVQKLKWIVSGRTARQLRHSYYRITHLPTIPETVP", "length": 295, "header": "sp|Q5E9I1-1|CCNG1_BOVIN Isoform 1 of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG1 PE=2 SV=1 CANONICAL=Q5E9I1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P6G3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1/entry#A0ABI0P6G3-1", "sequence": { "sequence": "MIEVLTTTDSQKLLHQLNALLEQELRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSTEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENVPHERKSSLNFERLEAQLKACYCRIIFSKAKPSVLALSIIALEIQAQKYIELTEGVERLQKHSKDDYSNKK", "length": 239, "header": "tr|A0ABI0P6G3-1|A0ABI0P6G3_BOVIN Computationally mapped isoform of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG1 PE=3 SV=1 CANONICAL=Q5E9I1-1" }, "locus": { "chromosome": "7", "start_pos": 75122007, "end_pos": 75117390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106576.1" } ] } }, { "isoform_ac": "Q5E9I1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1/entry#Q5E9I1-1", "sequence": { "sequence": "MIEVLTTTDSQKLLHQLNALLEQELRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSTEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENVPHERKSSLNFERLEAQLKACYCRIIFSKAKPSVLALSIIALEIQAQKYIELTEGVERLQKHSKISGRDLTFWQELVSKCLAEYSSNKCAKPNVQKLKWIVSGRTARQLRHSYYRITHLPTIPETVP", "length": 295, "header": "sp|Q5E9I1-1|CCNG1_BOVIN Isoform 1 of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG1 PE=2 SV=1 CANONICAL=Q5E9I1-1" }, "locus": { "chromosome": "7", "start_pos": 75121018, "end_pos": 75117390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106093.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:281671", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281671", "resource": "KEGG Pathway" }, { "id": "R-BTA-6804757", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804757", "resource": "Reactome", "description": "Regulation of TP53 Degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BUH6-1", "protein_name": "Cyclin G1", "gene_name": "CCNG1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIETLVSSDARALLYQLTALLEHELRCQPKGSGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFHTETFSLAVNFLDRFLSKMKVQPKHLGCVGLSCFYLAVKATEEERNVPLATDLIRISQYRFTVSDMMRMEKIVLEKLSWKVKATTAFQFLQLYHSLIHENLSCERKRYLNFERLETQLKACHCRIMFSKAKPSVLALSIMALEIEEQKLLELTEALEFLQLHSKINSRDLTFWKELVLKCLTEYSSSKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPETSS", "length": 295 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H9Y6-1", "protein_name": "Cyclin-G1", "gene_name": "Ccng1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIEVLTTDSQKLLHQLNTLLEQESRCQPKVCGLKLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQAKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLIQDSLPFERRNDLNFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQALKYVELMEGIECIQKHSKINSRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPETVS", "length": 294 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P39950-1", "protein_name": "Cyclin-G1", "gene_name": "Ccng1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIEVLTTDSQKLLHQLNTLLEQESRCQPKVCGLKLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQAKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLIRETLPFERRNDLNFERLEAQLKACHCRIIFSKAKPSVLALAIIALEIQALKYVELTEGVECIQKHSKISGRDLTFWQELVSKCLTEYSSNKCSKPNGQKLKWIVSGRTARQLKHSYYRITHLPTIPETMG", "length": 294 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P51945-1", "protein_name": "Cyclin-G1", "gene_name": "Ccng1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEVLTTDSQKLLHQLNTLLEQESRCQPKVCGLKLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQAKHLGCVGLSCFYLAVKATEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLVHDTLPFERRNDLNFERLEAQLKACHCRIIFSKAKPSVLALSILALEIQALKYVELTEGVECIQKHSKISGRDLTFWQELVSKCLTEYSSNKCSKPNGQKLKWIVSGRTARQLKHSYYRITHLPTIPETIC", "length": 294 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P51959-1", "protein_name": "Cyclin-G1", "gene_name": "CCNG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP", "length": 295 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q52QT8-1", "protein_name": "Cyclin-G1", "gene_name": "CCNG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIEVPTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSLEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQESLPYERRNSLNFERLEAQLKACYCRIIFSKAKPSVLALSIIALEIQALKCVELAEGAECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP", "length": 295 }, "evidence": [ { "id": "Q5E9I1", "url": "https://omabrowser.org/oma/group/Q5E9I1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9I1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9I1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9I1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9I3-1", "uniprot_ac": "Q5E9I3", "uniprot_id": "OPALI_BOVIN", "mass": { "chemical_mass": 15771.0, "monoisotopic_mass": 15771.0 }, "refseq": {}, "gene_names": [ { "name": "OPALIN", "type": "recommended", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ] }, { "name": "TMEM10", "type": "synonym", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ] } ], "protein_names": [ { "name": "Opalin", "type": "recommended", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3/entry#names_and_taxonomy" } ] }, { "name": "Oligodendrocytic myelin paranodal and inner loop protein", "type": "synonym", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 10", "type": "synonym", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3#function" }, { "database": "UniProtKB", "id": "Q7M750", "url": "https://www.uniprot.org/uniprotkb/Q7M750#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OPALIN", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3", "locus": { "chromosome": "26", "start_pos": 17684314, "end_pos": 17698606, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011740", "url": "https://www.ensembl.org/id/ENSBTAG00000011740" } ] } } ], "crossref": [ { "id": "Q5E9I3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q5E9I3", "url": "https://www.orthodb.org/?gene=Q5E9I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21102:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21102:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFSLNFTLPANTTSSPVVTSGKGADCGPSLGLAAGIPSLVATALLVALLLILIHRRRRSSESTEEIERPCEISEIYDNPRVAENPRRSPTHEKNIMGAEEAHIYVKTVSGSQEPMRDTYRPAVEMERRRGLWWLIPRLSLE", "length": 142, "header": "sp|Q5E9I3-1|OPALI_BOVIN Isoform 1 of Opalin OS=Bos taurus OX=9913 GN=OPALIN PE=2 SV=1 CANONICAL=Q5E9I3-1" }, "isoforms": [ { "isoform_ac": "Q5E9I3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3/entry#Q5E9I3-1", "sequence": { "sequence": "MSFSLNFTLPANTTSSPVVTSGKGADCGPSLGLAAGIPSLVATALLVALLLILIHRRRRSSESTEEIERPCEISEIYDNPRVAENPRRSPTHEKNIMGAEEAHIYVKTVSGSQEPMRDTYRPAVEMERRRGLWWLIPRLSLE", "length": 142, "header": "sp|Q5E9I3-1|OPALI_BOVIN Isoform 1 of Opalin OS=Bos taurus OX=9913 GN=OPALIN PE=2 SV=1 CANONICAL=Q5E9I3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 12, "start_aa": "Asn", "end_pos": 12, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn12", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine;O-GalNAcylation", "icn3d_view": {}, "start_pos": 14, "start_aa": "Thr", "end_pos": 14, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr14", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 6, "start_aa": "Asn", "end_pos": 6, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn6", "evidence": [ { "id": "Q5E9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ], "pmid": "" }, { "name": "cell-cell contact zone", "id": "GO:0044291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044291", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of oligodendrocyte differentiation", "id": "GO:0048713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048713", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9I3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9I3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9I3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 6, 12 ], "o_linked_sites": [ 14 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J2-1", "uniprot_ac": "Q5E9J2", "uniprot_id": "CNPD1_BOVIN", "mass": { "chemical_mass": 45427.0, "monoisotopic_mass": 45427.0 }, "refseq": { "ac": "NP_001015538", "name": "protein CNPPD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538" }, "gene_names": [ { "name": "CNPPD1", "type": "recommended", "evidence": [ { "id": "Q5E9J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ] }, { "name": "C2H2orf24", "type": "synonym", "evidence": [ { "id": "NP_001015538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538" } ] }, { "name": "C2orf24", "type": "synonym", "evidence": [ { "id": "NP_001015538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538" } ] }, { "name": "CNPPD1", "type": "synonym", "evidence": [ { "id": "NP_001015538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538" } ] } ], "protein_names": [ { "name": "Protein CNPPD1", "type": "recommended", "evidence": [ { "id": "Q5E9J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2/entry#names_and_taxonomy" } ] }, { "name": "protein CNPPD1", "type": "synonym", "evidence": [ { "id": "NP_001015538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNPPD1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2", "locus": { "chromosome": "2", "start_pos": 107122277, "end_pos": 107126661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012619", "url": "https://www.ensembl.org/id/ENSBTAG00000012619" } ] } } ], "crossref": [ { "id": "Q5E9J2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20557", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20557", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507473", "url": "https://www.ncbi.nlm.nih.gov/gene/507473", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507473", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507473", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9J2", "url": "https://www.orthodb.org/?gene=Q5E9J2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15615", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15615", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15615:SF108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15615:SF108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015538", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLAGLLLDEEGTFSLTGFQDFTFLPGHQKLSARIRRRLYYGWDWETDCTLEELSSPVADIAVELLQKAAPSPIRRLQKKYVAHVSREACISPCAMMLALVYIERLRHRNPDYLQHVSSSDLFLISMMVASKYLYDEGEEEEVFNDEWGAAGGVAVPTLNALERGFLSAMDWRLYTDPREIFEVLSWLEGCVAEQQGRRRGWYTYTDLCVLLEQPAWQLVLGSLCQQLAKLSCLLAMAYVSSVALAVASMAVIHQSLGLSCSPPPGPPDLGLASRCLLEPCIPSPMPQCLPSPANASGCLEGNVVLRSLWGSLLVSLTPPPLPPPDPPAPPILLHNCPLCQKLQKDSPTCRACHHLNHTVPTGPPSPWSHSHGLAPPWPWSPMPPLLPQPQQCSLFSIMELARLKSFIFPG", "length": 411, "header": "sp|Q5E9J2-1|CNPD1_BOVIN Isoform 1 of Protein CNPPD1 OS=Bos taurus OX=9913 GN=CNPPD1 PE=2 SV=1 CANONICAL=Q5E9J2-1" }, "isoforms": [ { "isoform_ac": "Q5E9J2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2/entry#Q5E9J2-1", "sequence": { "sequence": "MDLAGLLLDEEGTFSLTGFQDFTFLPGHQKLSARIRRRLYYGWDWETDCTLEELSSPVADIAVELLQKAAPSPIRRLQKKYVAHVSREACISPCAMMLALVYIERLRHRNPDYLQHVSSSDLFLISMMVASKYLYDEGEEEEVFNDEWGAAGGVAVPTLNALERGFLSAMDWRLYTDPREIFEVLSWLEGCVAEQQGRRRGWYTYTDLCVLLEQPAWQLVLGSLCQQLAKLSCLLAMAYVSSVALAVASMAVIHQSLGLSCSPPPGPPDLGLASRCLLEPCIPSPMPQCLPSPANASGCLEGNVVLRSLWGSLLVSLTPPPLPPPDPPAPPILLHNCPLCQKLQKDSPTCRACHHLNHTVPTGPPSPWSHSHGLAPPWPWSPMPPLLPQPQQCSLFSIMELARLKSFIFPG", "length": 411, "header": "sp|Q5E9J2-1|CNPD1_BOVIN Isoform 1 of Protein CNPPD1 OS=Bos taurus OX=9913 GN=CNPPD1 PE=2 SV=1 CANONICAL=Q5E9J2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507473", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507473", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 411, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 357, "end_pos": 359 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J3-1", "uniprot_ac": "Q5E9J3", "uniprot_id": "RSLBB_BOVIN", "mass": { "chemical_mass": 27400.0, "monoisotopic_mass": 27400.0 }, "refseq": { "ac": "NP_001015635", "name": "ras-like protein family member 11B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015635" }, "gene_names": [ { "name": "RASL11B", "type": "recommended", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "name": "RASL11B", "type": "synonym", "evidence": [ { "id": "NP_001015635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015635" } ] } ], "protein_names": [ { "name": "Ras-like protein family member 11B", "type": "recommended", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3/entry#names_and_taxonomy" } ] }, { "name": "ras-like protein family member 11B", "type": "synonym", "evidence": [ { "id": "NP_001015635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015635" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASL11B", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3", "locus": { "chromosome": "6", "start_pos": 68534897, "end_pos": 68530424, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020647", "url": "https://www.ensembl.org/id/ENSBTAG00000020647" } ] } } ], "crossref": [ { "id": "Q5E9J3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020647", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020647", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528446", "url": "https://www.ncbi.nlm.nih.gov/gene/528446", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528446", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528446", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEVEPQH", "url": "https://omabrowser.org/oma/group/KEVEPQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J3", "url": "https://www.orthodb.org/?gene=Q5E9J3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45704", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45704", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0NYX9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYX9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSAAAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLAIQVQDTPGIQVHENGLSCTEQLNRCIRWADAVVIVFSITDYKSYELTSQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENDNDVYNAFHVLCKEVSHKQQPSGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 248, "header": "sp|Q5E9J3-1|RSLBB_BOVIN Isoform 1 of Ras-like protein family member 11B OS=Bos taurus OX=9913 GN=RASL11B PE=2 SV=1 CANONICAL=Q5E9J3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NYX9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3/entry#A0ABI0NYX9-1", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSAAAADCCLGAAGRRLVKIAVVGASGVGKTGHNLFFPLFIGNLYTRQVQIEGETLAIQVQDTPGIQVHENGLSCTEQLNRCIRWADAVVIVFSITDYKSYELTSQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENDNDVYNAFHVLCKEVSHKQQPSGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 239, "header": "tr|A0ABI0NYX9-1|A0ABI0NYX9_BOVIN Computationally mapped isoform of small monomeric GTPase OS=Bos taurus OX=9913 GN=RASL11B PE=3 SV=1 CANONICAL=Q5E9J3-1" }, "locus": { "chromosome": "6", "start_pos": 68533907, "end_pos": 68530623, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136559.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136559.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105579.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105579.1" } ] } }, { "isoform_ac": "Q5E9J3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3/entry#Q5E9J3-1", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSAAAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLAIQVQDTPGIQVHENGLSCTEQLNRCIRWADAVVIVFSITDYKSYELTSQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENDNDVYNAFHVLCKEVSHKQQPSGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 248, "header": "sp|Q5E9J3-1|RSLBB_BOVIN Isoform 1 of Ras-like protein family member 11B OS=Bos taurus OX=9913 GN=RASL11B PE=2 SV=1 CANONICAL=Q5E9J3-1" }, "locus": { "chromosome": "6", "start_pos": 68533907, "end_pos": 68530623, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027515.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027515.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027515.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027515.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:528446", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528446", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BWN3-1", "protein_name": "small monomeric GTPase", "gene_name": "RASL11B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLTQSMCTIAECAPGGEGCPAARPRLVKIAVVGGSGVGKTALVVRFLTRRFIGDYERNAGNLYSRHIQIDGEVLAIQVQDTPGVQIHEHSLDCNEQLNRCIRWADALVIVFSITDYKSYELLSHLYHHVRQMHPGNAVPVVIVANKADLLHIKEVEPQHGLQLANMLGCAFYEVSVSENYNDVFNAFHVLCKEVSKQQTTSTPERRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 241 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SE66-1", "protein_name": "small monomeric GTPase", "gene_name": "RASL11B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLIQNMCTISEYPAPGSAAAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLAIQVQDTPGIQVHENGLSCTEQLNRCIRWADAVVIVFSVTDYKSYELTGQLHQHVQQLHLGARLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENDNDVYNAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 248 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IHJ9-1", "protein_name": "small monomeric GTPase", "gene_name": "Rasl11b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSAAADYCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLAIQVQDTPGVQVHENGLSCNEQLNRCIRWADAVVIVFSITDHKSYELIGQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLAGMLGCSFYEVSVSENYNDVYNAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 247 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6IMA7-1", "protein_name": "Ras-like protein family member 11B", "gene_name": "Rasl11b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSTAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVHIEGETLAIQVQDTPGIQVHENGLSCNEQLNRCIRWADAVVIVFSITDHKSYELISQLHQHVQQLHPGTRLPVVVVANKADLLHVKQVDPQLGLQLASMLGCSFYEVSVSENYNDVYSAFHVLCKEVSPKQQASGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 247 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P0U3-1", "protein_name": "Ras-like protein family member 11B", "gene_name": "rasl11b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLIQNMSTIAEYPSADCPSSRVIKIAVIGGSGVGKTALVVRFLTKRFIGDYERNVGNLYSREVQIDGEQVAIQVQDTPGVQVNANGLSCTDHVSRSIQWADAVVMVYSVTDRKSFDLIGQLHQLVTRTHSDRSIPIILVANKADLLHVRRVDAQEGPVLSSALSCSFYEVSASEDYNQVHSAFHRLCVDLAKLQPQTPINATSSVTEKKRSPLIPRPKSPNMQDLKRRFKQVLSAKVRTVTSV", "length": 244 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q922H7-1", "protein_name": "Ras-like protein family member 11B", "gene_name": "Rasl11b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGSTAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVHIEGETLAIQVQDTPGIQVHENGLSCSEQLNRCIRWADAVVLVFSITDHKSYELISQLHQHVQQLHPGTRLPVVLVANKADLLHVKQVDPQLGLQLASMLGCSFYEVSVSENYNDVYNAFHVLCKEVSPKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 247 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BPW5-1", "protein_name": "Ras-like protein family member 11B", "gene_name": "RASL11B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLIQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSITDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV", "length": 248 }, "evidence": [ { "id": "Q5E9J3", "url": "https://omabrowser.org/oma/group/Q5E9J3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor binding", "id": "GO:0005160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005160", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J3", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 248, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J8-1", "uniprot_ac": "Q5E9J8", "uniprot_id": "RIC8A_BOVIN", "mass": { "chemical_mass": 59499.0, "monoisotopic_mass": 59499.0 }, "refseq": { "ac": "NP_001015627", "name": "chaperone Ric-8A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" }, "gene_names": [ { "name": "RIC8A", "type": "recommended", "evidence": [ { "id": "Q5E9J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ] }, { "name": "RIC8A", "type": "synonym", "evidence": [ { "id": "NP_001015627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ] }, { "name": "RIC8", "type": "synonym", "evidence": [ { "id": "NP_001015627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ] } ], "protein_names": [ { "name": "Chaperone Ric-8A", "type": "recommended", "evidence": [ { "id": "Q5E9J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8/entry#names_and_taxonomy" } ] }, { "name": "Synembryn-A", "type": "synonym", "evidence": [ { "id": "Q5E9J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8/entry#names_and_taxonomy" } ] }, { "name": "chaperone Ric-8A", "type": "synonym", "evidence": [ { "id": "NP_001015627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ] }, { "name": "resistance to inhibitors of cholinesterase 8 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001015627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ] }, { "name": "synembryn-A", "type": "synonym", "evidence": [ { "id": "NP_001015627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ] } ], "function": [ { "annotation": "Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8#function" }, { "database": "UniProtKB", "id": "Q9NPQ8", "url": "https://www.uniprot.org/uniprotkb/Q9NPQ8#function" }, { "database": "UniProtKB", "id": "Q80ZG1", "url": "https://www.uniprot.org/uniprotkb/Q80ZG1#function" } ] }, { "annotation": "Study reports two crystal structures of bovine Ric8A, one in the apo form and the other in complex with a tagged C-terminal fragment of Galpha. These structures reveal two principal domains of Ric8A: an armadillo-fold core and a flexible C-terminal tail. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001015627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" }, { "database": "PubMed", "id": "31300652", "url": "https://glygen.org/publication/PubMed/31300652" } ] }, { "annotation": "The flexible C-terminal tail of Ric8A interacts with the effector surface of Galpha.", "evidence": [ { "database": "RefSeq", "id": "NP_001015627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" }, { "database": "PubMed", "id": "31624147", "url": "https://glygen.org/publication/PubMed/31624147" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIC8A", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8", "locus": {} } ], "crossref": [ { "id": "Q5E9J8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002042", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002042", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521037", "url": "https://www.ncbi.nlm.nih.gov/gene/521037", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6N85", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6N85&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6N86", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6N86&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR008376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521037", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521037", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NADPIFT", "url": "https://omabrowser.org/oma/group/NADPIFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J8", "url": "https://www.orthodb.org/?gene=Q5E9J8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12425", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12425", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12425:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12425:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006n85", "url": "https://www.rcsb.org/structure/pdb_00006n85", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006n86", "url": "https://www.rcsb.org/structure/pdb_00006n86", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6N85", "url": "https://www.rcsb.org/structure/6N85", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6N86", "url": "https://www.rcsb.org/structure/6N86", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF10165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRAVADALETGEEDVVMEALRAYNRENSQSFTFDDAQQEDRKRLAKLLVSVLEQGLPPSRRVIWLQSIRILSRDRSCLDSFTSRRSLQALACYAGISASQGSVPEPLNMDVVLESLKCLCNLVLSSPVAQALAAEAGLVVRLAERVGLCRQSSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELQGVRLLTRALELTLGMTEGERHPELLPPQETERAMEILKVLFNITFDSIKREVDEEDAALYRHLGTLLRHCVMLAAAGDRTEELHGHAVNLLGNLPVKCLDVLLTLEPHEGSLEFLGVNMDVIRVLLSFMEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGELLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGQLTSLQDAMCETMEGQLSSDPDSDPD", "length": 530, "header": "sp|Q5E9J8-1|RIC8A_BOVIN Isoform 1 of Chaperone Ric-8A OS=Bos taurus OX=9913 GN=RIC8A PE=1 SV=1 CANONICAL=Q5E9J8-1" }, "isoforms": [ { "isoform_ac": "Q5E9J8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8/entry#Q5E9J8-1", "sequence": { "sequence": "MEPRAVADALETGEEDVVMEALRAYNRENSQSFTFDDAQQEDRKRLAKLLVSVLEQGLPPSRRVIWLQSIRILSRDRSCLDSFTSRRSLQALACYAGISASQGSVPEPLNMDVVLESLKCLCNLVLSSPVAQALAAEAGLVVRLAERVGLCRQSSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELQGVRLLTRALELTLGMTEGERHPELLPPQETERAMEILKVLFNITFDSIKREVDEEDAALYRHLGTLLRHCVMLAAAGDRTEELHGHAVNLLGNLPVKCLDVLLTLEPHEGSLEFLGVNMDVIRVLLSFMEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGELLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGQLTSLQDAMCETMEGQLSSDPDSDPD", "length": 530, "header": "sp|Q5E9J8-1|RIC8A_BOVIN Isoform 1 of Chaperone Ric-8A OS=Bos taurus OX=9913 GN=RIC8A PE=1 SV=1 CANONICAL=Q5E9J8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 435, "end_pos": 435, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Ser435" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Thr440" }, { "start_pos": 442, "end_pos": 442, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Thr442" }, { "start_pos": 501, "end_pos": 501, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Ser501" }, { "start_pos": 522, "end_pos": 522, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Ser522" }, { "start_pos": 523, "end_pos": 523, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Ser523" }, { "start_pos": 527, "end_pos": 527, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "site_lbl": "Ser527" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Structural underpinnings of Ric8A function as a G-protein \u03b1-subunit chaperone and guanine-nucleotide exchange factor.", "journal": "Nature communications", "date": "2019-07-12", "authors": "Srivastava Dhiraj, Gakhar Lokesh, Artemyev Nikolai O", "evidence": [ { "database": "RefSeq", "id": "NP_001015627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ], "reference": [ { "type": "PubMed", "id": "31300652", "url": "https://glygen.org/publication/PubMed/31300652" } ] }, { "title": "Large-scale conformational rearrangement of the \u03b15-helix of G\u03b1 subunits in complex with the guanine nucleotide exchange factor Ric8A.", "journal": "The Journal of biological chemistry", "date": "2019-11-22", "authors": "Srivastava Dhiraj, Artemyev Nikolai O", "evidence": [ { "database": "RefSeq", "id": "NP_001015627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015627" } ], "reference": [ { "type": "PubMed", "id": "31624147", "url": "https://glygen.org/publication/PubMed/31624147" } ] } ], "pathway": [ { "id": "bta:521037", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521037", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A098KXF9-1", "protein_name": "Synembryn", "gene_name": "Ric8a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPRAVADALETGEEDTVTEALQSFNREHSQSFTFDDAQQEDRKRLAKLLVSLLEQGLSPSHRVTWLQTIRILTRDRSCLDSFASRQSLHALACYADITISEEPIPQPPDMDVLLESLKCLCNLVLSSPAAQMLAAEARLVVRLVERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTEALELTLGVGPKEKPPVVLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVAAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMEVISALLAFLEKRLHQTHRLKECVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD", "length": 530 }, "evidence": [ { "id": "Q5E9J8", "url": "https://omabrowser.org/oma/group/Q5E9J8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TIR3-1", "protein_name": "Chaperone Ric-8A", "gene_name": "Ric8a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD", "length": 530 }, "evidence": [ { "id": "Q5E9J8", "url": "https://omabrowser.org/oma/group/Q5E9J8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5ZL77-1", "protein_name": "Chaperone Ric-8A", "gene_name": "RIC8A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELRTVVATVESGEQDAVLKVLQIYNQEKSQCFTFDDEEREERKKMAQLLIKFLERELQPSCQVTCLESIRILSRDKYCLEPFTTEEGLKTLSRHAGIDYSEELIREVPDLEVILESLKCLCNIVFSSPRAQELTAEARLVVGLTKRIKLYNERSLPHEVKFFDLRLLFLLTALRVDIRQQLAQELRGISLMTDTLELTLGVKWMDPYEVATEEGLLPPLPRQETERAMEILKVLFNITFDSSKREVDEEDAALYRHLGALLRHCLMISADGEDRTEEFHSHTVNLLGNLPLKCLDVLLTPKVRPGSLEYMGVNMDAVNILLDFLERRLDRGHKLKESLTPVLNLLTESARVHRQTRKFLKAKVLPPLRDVKNRPEVGNSLRNKLVRLMTHIDTDVKHCAAEFLFVLCKESVSRFVKYTGYGNAAGLLAARGLMAGGREEGEYSEDEDTDTEEYKEAKPNINPVTGRVEEKLPNPMEGMTEEQKEYEAMKLVNMFDKLSREQVIQPMGITPSGNLAPMENAIRDMADERSSSDSDLGLD", "length": 539 }, "evidence": [ { "id": "Q5E9J8", "url": "https://omabrowser.org/oma/group/Q5E9J8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9NPQ8-1", "protein_name": "Chaperone Ric-8A", "gene_name": "RIC8A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD", "length": 531 }, "evidence": [ { "id": "Q5E9J8", "url": "https://omabrowser.org/oma/group/Q5E9J8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W358-1", "protein_name": "Chaperone Ric-8", "gene_name": "ric8a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "METEHLKRLEAKEADHIPAILDEFNTKNADLLVFDSFRTDNLWHELWLAIFGILDDQRLSHLHTQCLNTVRILTRDEFSLQTNYIEQEVNTLLKLARIEAGSLKLPATPDELKQEEREEPQLEPSQAQSEVIAEALKCLCNLVYQSSDCRRQCLRQHCLDAILKRVASSMRHPCALEYYDMKLLFLLTALEPAARSRLQIDLNGLTYMTKWLDDKLGEDSVGEEQLNIICELLKVMFNVTSAPDKSPNEYEIQSLHLTGVLRELLLRFGDLATEKDRAVVTHAINLLTNISGSCLTELTLRCSNAELESHKEREQDNEKEKDTEAGAGAKPRECCSQCFEKRNVRSLDVLLRYLRQSLAQQEAEASSHELLSPVLTVLVKCARSDRVMRHYLRQEILPPLRDVSQRPEVGQELRNHLCRFLTLPAMILRDLSAELLFVLCKENVGRMIKYTGYGNAAGLFAKRGILDCRRVEGTDYSSDSEDSDTEEYKQQQQGINPVLGCVEPRSKSHLDDISEEQKEYEAMQLVNLIEQLRQGGIVKPAMIDKDGRPQPLEHILQLQEELPQQQLDQKRKT", "length": 573 }, "evidence": [ { "id": "Q5E9J8", "url": "https://omabrowser.org/oma/group/Q5E9J8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G-protein alpha-subunit binding", "id": "GO:0001965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001965", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J8", "url": "https://www.uniprot.org/uniprotkb/Q5E9J8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 530, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J8" }, { "pdb_id": "6n85", "pdb_chain": "b", "start_pos": 1, "end_pos": 492, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/6n85.pdb", "url_external": "https://www.rcsb.org/structure/6n85" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 435, 440, 442, 501, 522, 523, 527 ], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9K1-1", "uniprot_ac": "Q5E9K1", "uniprot_id": "COMD5_BOVIN", "mass": { "chemical_mass": 24502.0, "monoisotopic_mass": 24502.0 }, "refseq": { "ac": "NP_001014850", "name": "COMM domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014850" }, "gene_names": [ { "name": "COMMD5", "type": "recommended", "evidence": [ { "id": "Q5E9K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ] }, { "name": "COMMD5", "type": "synonym", "evidence": [ { "id": "NP_001014850", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014850" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 5", "type": "recommended", "evidence": [ { "id": "Q5E9K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001014850", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014850" } ] }, { "name": "hypertension-related calcium-regulated", "type": "synonym", "evidence": [ { "id": "NP_001014850", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014850" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1#function" }, { "database": "UniProtKB", "id": "Q9GZQ3", "url": "https://www.uniprot.org/uniprotkb/Q9GZQ3#function" }, { "database": "UniProtKB", "id": "Q9ERR2", "url": "https://www.uniprot.org/uniprotkb/Q9ERR2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD5", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1", "locus": { "chromosome": "14", "start_pos": 336990, "end_pos": 350316, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018455", "url": "https://www.ensembl.org/id/ENSBTAG00000018455" } ] } } ], "crossref": [ { "id": "Q5E9K1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9K1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018455", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018455", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04753", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504807", "url": "https://www.ncbi.nlm.nih.gov/gene/504807", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504807", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504807", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQRTKFN", "url": "https://omabrowser.org/oma/group/IQRTKFN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9K1", "url": "https://www.orthodb.org/?gene=Q5E9K1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15666", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15666", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15666:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15666:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21672", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21672", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014850", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9K1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAVGPAAAHLHRPGDSHSDCVSFLGAQLPPEVAAMPQLLGDLDRATFRKLLKLVVSSLQGEDCREAVQHLRAGANLPEEQLGALIAGTHTLLQQALRLPPASLKPDTFKNQLQELCIPQDLVVDLASVVFGSQRPLLDSVARQQGAWLPHIADFRWRVDVAISTSALARSLQPSVLMHLKLSDGSALRFEVPTAKFQELRFAVALVLKEMADLEKRCERKLQD", "length": 224, "header": "sp|Q5E9K1-1|COMD5_BOVIN Isoform 1 of COMM domain-containing protein 5 OS=Bos taurus OX=9913 GN=COMMD5 PE=2 SV=1 CANONICAL=Q5E9K1-1" }, "isoforms": [ { "isoform_ac": "Q5E9K1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1/entry#Q5E9K1-1", "sequence": { "sequence": "MSAVGPAAAHLHRPGDSHSDCVSFLGAQLPPEVAAMPQLLGDLDRATFRKLLKLVVSSLQGEDCREAVQHLRAGANLPEEQLGALIAGTHTLLQQALRLPPASLKPDTFKNQLQELCIPQDLVVDLASVVFGSQRPLLDSVARQQGAWLPHIADFRWRVDVAISTSALARSLQPSVLMHLKLSDGSALRFEVPTAKFQELRFAVALVLKEMADLEKRCERKLQD", "length": 224, "header": "sp|Q5E9K1-1|COMD5_BOVIN Isoform 1 of COMM domain-containing protein 5 OS=Bos taurus OX=9913 GN=COMMD5 PE=2 SV=1 CANONICAL=Q5E9K1-1" }, "locus": { "chromosome": "14", "start_pos": 341410, "end_pos": 340739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104429.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104429.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090308.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090308.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:504807", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504807", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q86IW8-1", "protein_name": "COMM domain-containing protein 5", "gene_name": "commd5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIPVCQKFEQTFIKDILSLLVLYMKTKMINLVKKEEEDKLNQITESIHDKLTVSSNDNKVDPNLSSIVFTGLYYILKVALKKKVSNQIFVADITDLKLPQNLITDLTNIYNTQSKDLAERSNNDKILFPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSKVFEVSIDNFHKLRYNAAKLLKDLEDLEQIQILSKLENK", "length": 205 }, "evidence": [ { "id": "Q5E9K1", "url": "https://omabrowser.org/oma/group/Q5E9K1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9GZQ3-1", "protein_name": "COMM domain-containing protein 5", "gene_name": "COMMD5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD", "length": 224 }, "evidence": [ { "id": "Q5E9K1", "url": "https://omabrowser.org/oma/group/Q5E9K1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9K1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 224, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9K1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9K1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K1" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 151, "end_pos": 215, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9L3-1", "uniprot_ac": "Q5E9L3", "uniprot_id": "MISSL_BOVIN", "mass": { "chemical_mass": 23798.0, "monoisotopic_mass": 23798.0 }, "refseq": { "ac": "NP_001014963", "name": "MAPK-interacting and spindle-stabilizing protein-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963" }, "gene_names": [ { "name": "MAPK1IP1L", "type": "recommended", "evidence": [ { "id": "Q5E9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ] }, { "name": "C14orf32", "type": "synonym", "evidence": [ { "id": "NP_001014963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963" } ] }, { "name": "MAPK1IP1L", "type": "synonym", "evidence": [ { "id": "NP_001014963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963" } ] } ], "protein_names": [ { "name": "MAPK-interacting and spindle-stabilizing protein-like", "type": "recommended", "evidence": [ { "id": "Q5E9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3/entry#names_and_taxonomy" } ] }, { "name": "MAPK-interacting and spindle-stabilizing protein-like", "type": "synonym", "evidence": [ { "id": "NP_001014963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963" } ] }, { "name": "MAPK-interacting and spindle-stabilizing protein", "type": "synonym", "evidence": [ { "id": "NP_001014963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963" } ] }, { "name": "Mitogen-activated protein kinase 1-interacting protein 1-like", "type": "synonym", "evidence": [ { "id": "Q5E9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAPK1IP1L", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3", "locus": { "chromosome": "10", "start_pos": 67538325, "end_pos": 67525428, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021986", "url": "https://www.ensembl.org/id/ENSBTAG00000021986" } ] } } ], "crossref": [ { "id": "Q5E9L3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021986", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021986", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540411", "url": "https://www.ncbi.nlm.nih.gov/gene/540411", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540411", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540411", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPSMPYP", "url": "https://omabrowser.org/oma/group/TPSMPYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9L3", "url": "https://www.orthodb.org/?gene=Q5E9L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35973:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35973:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014963", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9L3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDEFSLADALPENSPAKTSAVSNTKPGQPPQGWPGSNPWNNPSAPPAVPSGLPPSATPSPVPFGPTPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPAGSYPTPGLYPTPNNPFQVPSGPSGAPPMPGGPHSYH", "length": 240, "header": "sp|Q5E9L3-1|MISSL_BOVIN Isoform 1 of MAPK-interacting and spindle-stabilizing protein-like OS=Bos taurus OX=9913 GN=MAPK1IP1L PE=2 SV=3 CANONICAL=Q5E9L3-1" }, "isoforms": [ { "isoform_ac": "Q5E9L3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3/entry#Q5E9L3-1", "sequence": { "sequence": "MSDEFSLADALPENSPAKTSAVSNTKPGQPPQGWPGSNPWNNPSAPPAVPSGLPPSATPSPVPFGPTPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPAGSYPTPGLYPTPNNPFQVPSGPSGAPPMPGGPHSYH", "length": 240, "header": "sp|Q5E9L3-1|MISSL_BOVIN Isoform 1 of MAPK-interacting and spindle-stabilizing protein-like OS=Bos taurus OX=9913 GN=MAPK1IP1L PE=2 SV=3 CANONICAL=Q5E9L3-1" }, "locus": { "chromosome": "10", "start_pos": 67533979, "end_pos": 67531624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043779.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043779.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041324.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041324.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 108, "start_aa": "Thr", "end_pos": 108, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 113, "start_aa": "Thr", "end_pos": 113, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr113", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 209, "start_aa": "Thr", "end_pos": 209, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr209", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 58, "start_aa": "Thr", "end_pos": 58, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr58", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ], "site_lbl": "Ser15" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ], "site_lbl": "Ser2" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L3", "url": "https://www.uniprot.org/uniprotkb/Q5E9L3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540411", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540411", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZSB4-1", "protein_name": "MAPK-interacting and spindle-stabilizing protein-like", "gene_name": "MAPK1IP1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDEFSLADALPDHSPAKTSAVSNTKPGQPPQGWPGSSPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPAVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPAPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPGPYPAPAGSYPSPGLYPAPSNPFQVPSGPSGAPPMPGGPHVSV", "length": 245 }, "evidence": [ { "id": "Q5E9L3", "url": "https://omabrowser.org/oma/group/Q5E9L3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZNX9-1", "protein_name": "MAPK-interacting and spindle-stabilizing protein-like", "gene_name": "Mapk1ip1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDEFSLADALPEQSSAKTPAVTNTKAGHSPQGWPGSSPWSNPSAPPAMPSGLPPSSAAPSTVPFGPVPTGMYPSMPPAGPPPGPFPPSGPSCPPPGVPYPAPAVPGPGPTGPYATPNMPLPELPRPYGAPTDPAAAGTLGPWGSISSGPWAPGIAGQHPNMPYRSPGPYPTVPPPVSGAPPVPWGTVPPGAWGPPAPYPGPAGSYPTPGPHPTLNNPYQVPSGPAGAPPMPGGPHKVNEVPGGSLSDDSDQKSSPESTGQVKSSPESTGQVKLLKADDKPVRKRHPKRKRKPLTWGDIKNLTYQAETLGKQQGYNTNDPKMMLLCLITILHVNSQHDRSDPN", "length": 343 }, "evidence": [ { "id": "Q5E9L3", "url": "https://omabrowser.org/oma/group/Q5E9L3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BH93-1", "protein_name": "MAPK-interacting and spindle-stabilizing protein-like", "gene_name": "Mapk1ip1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDEFSLADALPEQSSAKPPAVTNTKAGHSSQGWPGSSPWSNPSAPPAMPSGLPPSSAAPSTVPFGPVPTGMYPSMPPTGPPPGPPGPFPPPGPSCPPPGVPYPAPAVPGPGPTGPYATPNMPMPELPRPYGAPTDPAAAGSLGPWGPMSSGPWAPGIAGQHPNMPYRSPGPYPTVPPPVSGAPPVPWGTVPPGAWGPAAPYPGPAGSYPTPAPHPALNNPYQVPSGPAGAPPMPGGPHSYH", "length": 242 }, "evidence": [ { "id": "Q5E9L3", "url": "https://omabrowser.org/oma/group/Q5E9L3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDC0-1", "protein_name": "MAPK-interacting and spindle-stabilizing protein-like", "gene_name": "MAPK1IP1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSNPWNNPSAPSSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAPPMPGGPHSYH", "length": 245 }, "evidence": [ { "id": "Q5E9L3", "url": "https://omabrowser.org/oma/group/Q5E9L3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9C5S0-1", "protein_name": "Classical arabinogalactan protein 9", "gene_name": "AGP9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARSFAIAVICIVLIAGVTGQAPTSPPTATPAPPTPTTPPPAATPPPVSAPPPVTTSPPPVTTAPPPANPPPPVSSPPPASPPPATPPPVASPPPPVASPPPATPPPVATPPPAPLASPPAQVPAPAPTTKPDSPSPSPSSSPPLPSSDAPGPSTDSISPAPSPTDVNDQNGASKMVSSLVFGSVLVWFMI", "length": 191 }, "evidence": [ { "id": "Q5E9L3", "url": "https://omabrowser.org/oma/group/Q5E9L3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 240, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9L3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 58, 67, 78, 108, 113, 209 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2, 6, 15 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9L4-1", "uniprot_ac": "Q5E9L4", "uniprot_id": "B2L14_BOVIN", "mass": { "chemical_mass": 36839.0, "monoisotopic_mass": 36839.0 }, "refseq": { "ac": "NP_001015544", "name": "apoptosis facilitator Bcl-2-like protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544" }, "gene_names": [ { "name": "BCL2L14", "type": "recommended", "evidence": [ { "id": "Q5E9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ] }, { "name": "BCL2L14", "type": "synonym", "evidence": [ { "id": "NP_001015544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544" } ] } ], "protein_names": [ { "name": "Apoptosis facilitator Bcl-2-like protein 14", "type": "recommended", "evidence": [ { "id": "Q5E9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4/entry#names_and_taxonomy" } ] }, { "name": "BCL2-like 14 (apoptosis facilitator)", "type": "synonym", "evidence": [ { "id": "NP_001015544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544" } ] }, { "name": "Bcl2-L-14", "type": "synonym", "evidence": [ { "id": "Q5E9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4/entry#names_and_taxonomy" } ] }, { "name": "apoptosis facilitator Bcl-2-like protein 14", "type": "synonym", "evidence": [ { "id": "NP_001015544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544" } ] }, { "name": "bcl2-L-14", "type": "synonym", "evidence": [ { "id": "NP_001015544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544" } ] } ], "function": [ { "annotation": "Plays a role in apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL2L14", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4", "locus": { "chromosome": "5", "start_pos": 97725269, "end_pos": 97748884, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047225", "url": "https://www.ensembl.org/id/ENSBTAG00000047225" } ] } } ], "crossref": [ { "id": "Q5E9L4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "508365", "url": "https://www.ncbi.nlm.nih.gov/gene/508365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9L4", "url": "https://www.orthodb.org/?gene=Q5E9L4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14965:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14965:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001015544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9L4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCTASPCDLEEIPLDDEDSDSLEFKILEFYVKHHVFQNTSAILSPKHLRTRSLSQKGPERWPVSEAWTQGPWPCRHSQSSEKAINLTKKKSSWRTLFGVAEKEEDSQSSPPEICAQAQRSGVPQARPRSPKWPRSRSSMDQRLEHKAADPRVVSIANRVAEIVYSWPPPEEVHSQGGGFKSKGVLVFQGPQGQSGAESTKKEGEDQIIARIVELLKYSGEQLERELKKDKVLMTCFQDVLSYSVVKTITDQFLRGVDTRGESEVKAQSFKAALAIDVIAKLTTIDNHPMNRVLGFGTKYLKENFSPWIQQHGGWEKILRMPHEEVD", "length": 326, "header": "sp|Q5E9L4-1|B2L14_BOVIN Isoform 1 of Apoptosis facilitator Bcl-2-like protein 14 OS=Bos taurus OX=9913 GN=BCL2L14 PE=2 SV=1 CANONICAL=Q5E9L4-1" }, "isoforms": [ { "isoform_ac": "Q5E9L4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4/entry#Q5E9L4-1", "sequence": { "sequence": "MCTASPCDLEEIPLDDEDSDSLEFKILEFYVKHHVFQNTSAILSPKHLRTRSLSQKGPERWPVSEAWTQGPWPCRHSQSSEKAINLTKKKSSWRTLFGVAEKEEDSQSSPPEICAQAQRSGVPQARPRSPKWPRSRSSMDQRLEHKAADPRVVSIANRVAEIVYSWPPPEEVHSQGGGFKSKGVLVFQGPQGQSGAESTKKEGEDQIIARIVELLKYSGEQLERELKKDKVLMTCFQDVLSYSVVKTITDQFLRGVDTRGESEVKAQSFKAALAIDVIAKLTTIDNHPMNRVLGFGTKYLKENFSPWIQQHGGWEKILRMPHEEVD", "length": 326, "header": "sp|Q5E9L4-1|B2L14_BOVIN Isoform 1 of Apoptosis facilitator Bcl-2-like protein 14 OS=Bos taurus OX=9913 GN=BCL2L14 PE=2 SV=1 CANONICAL=Q5E9L4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "site_lbl": "Ser44" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508365", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L4", "url": "https://www.uniprot.org/uniprotkb/Q5E9L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9L4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9L4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9L4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 44 ], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9M5-1", "uniprot_ac": "Q5E9M5", "uniprot_id": "SNPC3_BOVIN", "mass": { "chemical_mass": 46961.0, "monoisotopic_mass": 46961.0 }, "refseq": {}, "gene_names": [ { "name": "SNAPC3", "type": "recommended", "evidence": [ { "id": "Q5E9M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ] } ], "protein_names": [ { "name": "snRNA-activating protein complex subunit 3", "type": "recommended", "evidence": [ { "id": "Q5E9M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5/entry#names_and_taxonomy" } ] }, { "name": "SNAPc subunit 3", "type": "synonym", "evidence": [ { "id": "Q5E9M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5/entry#names_and_taxonomy" } ] }, { "name": "Small nuclear RNA-activating complex polypeptide 3", "type": "synonym", "evidence": [ { "id": "Q5E9M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAPC3", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5", "locus": { "chromosome": "8", "start_pos": 28835484, "end_pos": 28874253, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004592", "url": "https://www.ensembl.org/id/ENSBTAG00000004592" } ] } } ], "crossref": [ { "id": "Q5E9M5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9M5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR022042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q5E9M5", "url": "https://www.orthodb.org/?gene=Q5E9M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13421", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13421", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13421:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13421:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12251", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12251", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9M5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGSRGGPACGRMEDRQDPAPSSGGCGFPEYELPELNTRAFHVGAFGELWRCRLRGKGDLSLKEPPAPAVPEGDTVADSGREDAAVARDLGCSLEAAAELRAVCGLDKLKCLEEGEDPEVIPENTDLVTLGVRKRLLEHRKETITIDRVCRQETFAYEMESHAMGKKPENPADMIEEGELILSVNILYPVIFHKHKEHKPYQTILVLGSQKLTELRDAICCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTAKMEDFTFNDLYIKLGFPYLYCHQGDCEHVVVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN", "length": 412, "header": "sp|Q5E9M5-1|SNPC3_BOVIN Isoform 1 of snRNA-activating protein complex subunit 3 OS=Bos taurus OX=9913 GN=SNAPC3 PE=2 SV=1 CANONICAL=Q5E9M5-1" }, "isoforms": [ { "isoform_ac": "Q5E9M5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5/entry#Q5E9M5-1", "sequence": { "sequence": "MAEGSRGGPACGRMEDRQDPAPSSGGCGFPEYELPELNTRAFHVGAFGELWRCRLRGKGDLSLKEPPAPAVPEGDTVADSGREDAAVARDLGCSLEAAAELRAVCGLDKLKCLEEGEDPEVIPENTDLVTLGVRKRLLEHRKETITIDRVCRQETFAYEMESHAMGKKPENPADMIEEGELILSVNILYPVIFHKHKEHKPYQTILVLGSQKLTELRDAICCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTAKMEDFTFNDLYIKLGFPYLYCHQGDCEHVVVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN", "length": 412, "header": "sp|Q5E9M5-1|SNPC3_BOVIN Isoform 1 of snRNA-activating protein complex subunit 3 OS=Bos taurus OX=9913 GN=SNAPC3 PE=2 SV=1 CANONICAL=Q5E9M5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "bent DNA binding", "id": "GO:0003681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003681", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" }, { "name": "RNA polymerase III type 3 promoter sequence-specific DNA binding", "id": "GO:0001006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001006", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" }, { "name": "snRNA-activating protein complex", "id": "GO:0019185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019185", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "snRNA transcription by RNA polymerase II", "id": "GO:0042795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042795", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" }, { "name": "snRNA transcription by RNA polymerase III", "id": "GO:0042796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042796", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M5", "url": "https://www.uniprot.org/uniprotkb/Q5E9M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9M5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 412, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9M5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9M5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 369, "end_pos": 371 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9M6-1", "uniprot_ac": "Q5E9M6", "uniprot_id": "NXPH1_BOVIN", "mass": { "chemical_mass": 31018.0, "monoisotopic_mass": 31018.0 }, "refseq": { "ac": "NP_001029934", "name": "neurexophilin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029934" }, "gene_names": [ { "name": "NXPH1", "type": "recommended", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6" } ] }, { "name": "NXPH1", "type": "synonym", "evidence": [ { "id": "NP_001029934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029934" } ] } ], "protein_names": [ { "name": "Neurexophilin-1", "type": "recommended", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6/entry#names_and_taxonomy" } ] }, { "name": "neurexophilin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029934" } ] } ], "function": [ { "annotation": "May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NXPH1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6", "locus": { "chromosome": "4", "start_pos": 16890379, "end_pos": 16833077, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006924", "url": "https://www.ensembl.org/id/ENSBTAG00000006924" } ] } } ], "crossref": [ { "id": "Q5E9M6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "614571", "url": "https://www.ncbi.nlm.nih.gov/gene/614571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614571", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9M6", "url": "https://www.orthodb.org/?gene=Q5E9M6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17103:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17103:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029934", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9M6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQAACWYVLLLLQPTVYLVTCANLTNGGKSELLKSGGSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG", "length": 271, "header": "sp|Q5E9M6-1|NXPH1_BOVIN Isoform 1 of Neurexophilin-1 OS=Bos taurus OX=9913 GN=NXPH1 PE=2 SV=1 CANONICAL=Q5E9M6-1" }, "isoforms": [ { "isoform_ac": "Q5E9M6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6/entry#Q5E9M6-1", "sequence": { "sequence": "MQAACWYVLLLLQPTVYLVTCANLTNGGKSELLKSGGSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG", "length": 271, "header": "sp|Q5E9M6-1|NXPH1_BOVIN Isoform 1 of Neurexophilin-1 OS=Bos taurus OX=9913 GN=NXPH1 PE=2 SV=1 CANONICAL=Q5E9M6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 156, "start_aa": "Asn", "end_pos": 156, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn156", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 162, "start_aa": "Asn", "end_pos": 162, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn162", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 23, "start_aa": "Asn", "end_pos": 23, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn23", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 68, "start_aa": "Asn", "end_pos": 68, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn68", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 93, "start_aa": "Asn", "end_pos": 93, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn93", "evidence": [ { "id": "Q5E9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614571", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614571", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M6", "url": "https://www.uniprot.org/uniprotkb/Q5E9M6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9M6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 271, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9M6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9M6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 23, 68, 93, 146, 156, 162 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 68, "end_pos": 70 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 6 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_n_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9N0-1", "uniprot_ac": "Q5E9N0", "uniprot_id": "BYST_BOVIN", "mass": { "chemical_mass": 49379.0, "monoisotopic_mass": 49379.0 }, "refseq": { "ac": "NP_001014924", "name": "bystin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014924" }, "gene_names": [ { "name": "BYSL", "type": "recommended", "evidence": [ { "id": "Q5E9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ] }, { "name": "BYSL", "type": "synonym", "evidence": [ { "id": "NP_001014924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014924" } ] } ], "protein_names": [ { "name": "Bystin", "type": "recommended", "evidence": [ { "id": "Q5E9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0/entry#names_and_taxonomy" } ] }, { "name": "bystin", "type": "synonym", "evidence": [ { "id": "NP_001014924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014924" } ] } ], "function": [ { "annotation": "Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0#function" }, { "database": "UniProtKB", "id": "Q13895", "url": "https://www.uniprot.org/uniprotkb/Q13895#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BYSL", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0", "locus": { "chromosome": "23", "start_pos": 15698295, "end_pos": 15687977, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010101", "url": "https://www.ensembl.org/id/ENSBTAG00000010101" } ] } } ], "crossref": [ { "id": "Q5E9N0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9N0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010101", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514128", "url": "https://www.ncbi.nlm.nih.gov/gene/514128", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514128", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514128", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TKLPVIW", "url": "https://omabrowser.org/oma/group/TKLPVIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9N0", "url": "https://www.orthodb.org/?gene=Q5E9N0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12821", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12821", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12821:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12821:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014924", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9N0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKFKAARGAGVQEKHAPLAEQILAGDAVRAGTREKRRGRGTGDEEEEYVGPRLTRRILQQARQQQEELEAEHGSGDRPAVPRERTTRLGPGVPQDGSDDEEWPTLEQAAARAGPGYQAEVVVDPEDERAIEMFMNQNPPARRTLADIIMEKLTEKQTEVETVMSEVSGFPVPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYITEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPVTME", "length": 435, "header": "sp|Q5E9N0-1|BYST_BOVIN Isoform 1 of Bystin OS=Bos taurus OX=9913 GN=BYSL PE=2 SV=1 CANONICAL=Q5E9N0-1" }, "isoforms": [ { "isoform_ac": "Q5E9N0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0/entry#Q5E9N0-1", "sequence": { "sequence": "MPKFKAARGAGVQEKHAPLAEQILAGDAVRAGTREKRRGRGTGDEEEEYVGPRLTRRILQQARQQQEELEAEHGSGDRPAVPRERTTRLGPGVPQDGSDDEEWPTLEQAAARAGPGYQAEVVVDPEDERAIEMFMNQNPPARRTLADIIMEKLTEKQTEVETVMSEVSGFPVPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYITEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPVTME", "length": 435, "header": "sp|Q5E9N0-1|BYST_BOVIN Isoform 1 of Bystin OS=Bos taurus OX=9913 GN=BYSL PE=2 SV=1 CANONICAL=Q5E9N0-1" }, "locus": { "chromosome": "23", "start_pos": 15696987, "end_pos": 15688300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013326.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013326.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013326.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013326.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 154, "end_pos": 154, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "site_lbl": "Thr154" }, { "start_pos": 165, "end_pos": 165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "site_lbl": "Ser165" }, { "start_pos": 412, "end_pos": 412, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "site_lbl": "Ser412" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514128", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514128", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A650-1", "protein_name": "Bystin like", "gene_name": "BYSL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKAARGAEPLHEQILRAAAPRVRHRRGREEGDDAEERDGGYVGPRLARRILREARKQQEELEAEHGPGAPARPPQRCAAPGGPDSEEDEEDEEWPSLQRAAEWDGRCGGGDVEVDPEDEKALEVFMSRAPPLRRTLADVIMEKITEKQTEVQTALSELSGRPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYITEPETWTAAAMYQATRIFSSNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIIGSILTKCSIPVLHSSAAMLKIAEMPYNGANSIFLRLLIDKKYALPFRVVDALVFHFLAFRTDQRTLPVLWHQSFLALCQRYKEDLSSEQKEALLELLKFHSHPQISAEIRRELANSKTRDVEGQEPAAME", "length": 428 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LH38-1", "protein_name": "Bystin like", "gene_name": "BYSL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKLKAARGAEGQEKHAPLADQILAGNAVRAGTREKRRGRGTGEEEEEYVGPRLTRRILQQARQQQEELEAEHGTGDRPAAPQDRTTRLGPGAPQDGSDDEEWPTLAKAATMTGPGYQAEVVIDPEDERAIELFMNKNPPARRTLADIIMEKLTEKKTEVESVMSEVSGLPLPRLNPRLLEVYRGVREVLSKYRSGKLPTAFKMIPALSNWEEILYVTEPEAWSAAAMYQATRIFASNLKEHKAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILLPLCESGTCTLREAIILGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLRFRTEKRELPVLWHQCLLTLVQRYKADLATEQKEALLELLRVQSHPQLSPEIRRELQSAVPRDVEDVPVTME", "length": 435 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54825-1", "protein_name": "Bystin", "gene_name": "Bysl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKFKVTRGASNREKHAPLAEQILAGNAVRAGTREKRRGREVEEEEEYVGPRLSRRILQQARQQQEELETDHGAGDRSAPPRERATRLGPGLPQDGSDEEDEEWPTLEKAAKMAGVDHQAEVIVDPEDERAIEMFMNKNPPVRRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGKLPKAFKVIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDGGVTME", "length": 436 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P38333-1", "protein_name": "Essential nuclear protein 1", "gene_name": "ENP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARASSTKARKQRHDPLLKDLDAAQGTLKKINKKKLAQNDAANHDAANEEDGYIDSKASRKILQLAKEQQDEIEGEELAESERNKQFEARFTTMSYDDEDEDEDEDEEAFGEDISDFEPEGDYKEEEEIVEIDEEDAAMFEQYFKKSDDFNSLSGSYNLADKIMASIREKESQVEDMQDDEPLANEQNTSRGNISSGLKSGEGVALPEKVIKAYTTVGSILKTWTHGKLPKLFKVIPSLRNWQDVIYVTNPEEWSPHVVYEATKLFVSNLTAKESQKFINLILLERFRDNIETSEDHSLNYHIYRAVKKSLYKPSAFFKGFLFPLVETGCNVREATIAGSVLAKVSVPALHSSAALSYLLRLPFSPPTTVFIKILLDKKYALPYQTVDDCVYYFMRFRILDDGSNGEDATRVLPVIWHKAFLTFAQRYKNDITQDQRDFLLETVRQRGHKDIGPEIRRELLAGASREFVDPQEANDDLMIDVN", "length": 483 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P51406-1", "protein_name": "Bystin", "gene_name": "bys", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGKPKKANVATIKNVNLEKQITEGRVAKNKNKDKVKLRAEESANIDARSSQKILAAAKLQQLELDEENFPSLVTVKKVNFSLNDGHVKEDEEVNETDLMADLDMDEDDVAAFERFQQPAQEGKRTLHLSKMIMQKIQEKEADIHTKISDEGSLKIEEIDPKVKEMYEGVRDVLKRYRSGKIPKAFKIIPKLRNWEQILFITEPHNWSAAAMFQGTRIFCSVLSQAMAQRFYNLVLLPRVRDDLCEYKKLNMHLYNALKRALFKPAAFMKGIILPLLEGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYSGANSIFIRYFLDKRYALPYRVVDAAVFHFLRFENDKRELPVLWHQSLLTFAQRYKNDISSEQRDALLQLLKKKSHFKITPDVRRELQAASCRDVEMMETDNGLAGQPAKMYTDADVEYEG", "length": 436 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q13895-1", "protein_name": "Bystin", "gene_name": "BYSL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKFKAARGVGGQEKHAPLADQILAGNAVRAGVREKRRGRGTGEAEEEYVGPRLSRRILQQARQQQEELEAEHGTGDKPAAPRERTTRLGPRMPQDGSDDEDEEWPTLEKAATMTAAGHHAEVVVDPEDERAIEMFMNKNPPARRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDVAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATDQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPITVE", "length": 437 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54IS0-1", "protein_name": "Bystin", "gene_name": "bysl", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGKDVKKVHKLRHDPLSKQIEESESAYQKPHKRVGKLRKKKAEMENDTGIDETESVIPSALSKKILDQIREQAIEVEVEDRKKEKQEKLLTFEQERIQSKLLSFNDFIDDDDDDEDADQDDNKRRSNGNDFDENDGFEQFSDTESQFGVGGEVEIDEEDERVLSMFMGGGGGDGQEQQFQTRFTLGDIIESKLKEHESRQVSSENAINPKVIDVYTKVGKLLETYTSGKIPRAFRILPNFTNWEDLLYLTRPDKWTPHSIRVATKLFCMSTNSKITQRFLSIVVLPRVRDNIAEYKKLNYHLYMALKKSLYRPAAFYKAILLPLAESGDCTLLEAKIIGSVVCKVSIPVLHSSVALMKLSQLTRYNGATSMFIRMLCDKKYALPYRVIDGLVDHFVMFDEEVRELPVLWHRALLSFVQRYKTDITKDQKEKLKIILRKHNHHIITAEIRRELFFSNSRGGVAPSNFTDDTSSMME", "length": 475 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q80WL2-1", "protein_name": "Bystin", "gene_name": "Bysl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKLKVTRGARNQERHAPLAEQILAGDAVRAGTREKRRRHGVEEEEEYVGPRLSRRILQQARQQQEELETEHATGDRPAKPRERATRLGPGVPQDGSDEEDEEWPTLEKAAKMTVVNHQAEVVVDPEDERAIEMFMNKNPPVRRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGILPKAFKIIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIISKCSIPVLHSSAAMLKIAEMEYSGASSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVVVTME", "length": 436 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8RWS4-1", "protein_name": "Bystin", "gene_name": "ENP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAKKRDRIVNTQPFISDDASVASSRKRSKVPKTHQKQEKLIEAGMSEKIMKQALAQQKEVADEENAERNPSSAAFAVAGAATAGEEQKILEEEEDDIDDFDGTFENQSQFDKQEEINEDDEKLFESFLNKNAPPQRTLTDIIIKKLKDKDADLAEEERPDPKMDPAITKLYKGVGKFMSEYTVGKLPKAFKLVTSMEHWEDVLYLTEPEKWSPNALYQATRIFASNLKDRQVQRFYNYVLLPRVREDIRKHKKLHFALYQALKKSLYKPSAFNQGILFPLCKSGTCNLREAVIIGSILEKCSIPMLHSCVALNRLAEMDYCGTTSYFIKVLLEKKYCMPYRVLDALVAHFMRFVDDIRVMPVIWHQSLLTFVQRYKYEILKEDKEHLQTLLQRQKHHLVTPEILRELKDSRNRGEKEDPMVDNFAPVPAKEDRFDIPEVPMEED", "length": 444 }, "evidence": [ { "id": "Q5E9N0", "url": "https://omabrowser.org/oma/group/Q5E9N0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" }, { "name": "preribosome, small subunit precursor", "id": "GO:0030688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030688", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N0", "url": "https://www.uniprot.org/uniprotkb/Q5E9N0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9N0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 435, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9N0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9N0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 98, 154, 165, 412 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9N2-1", "uniprot_ac": "Q5E9N2", "uniprot_id": "CNBP1_BOVIN", "mass": { "chemical_mass": 9228.0, "monoisotopic_mass": 9228.0 }, "refseq": { "ac": "NP_001032219", "name": "beta-catenin-interacting protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032219" }, "gene_names": [ { "name": "CTNNBIP1", "type": "recommended", "evidence": [ { "id": "Q5E9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ] }, { "name": "CTNNBIP1", "type": "synonym", "evidence": [ { "id": "NP_001032219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032219" } ] } ], "protein_names": [ { "name": "Beta-catenin-interacting protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2/entry#names_and_taxonomy" } ] }, { "name": "beta-catenin-interacting protein 1", "type": "synonym", "evidence": [ { "id": "NP_001032219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032219" } ] }, { "name": "beta-catenin-interacting protein ICAT", "type": "synonym", "evidence": [ { "id": "NP_001032219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032219" } ] } ], "function": [ { "annotation": "Prevents the interaction between CTNNB1 and TCF family members, and acts as a negative regulator of the Wnt signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2#function" }, { "database": "UniProtKB", "id": "A0AAF7AG29", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AG29#function" }, { "database": "UniProtKB", "id": "ARBA00054377", "url": "https://www.uniprot.org/uniprotkb/ARBA00054377#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTNNBIP1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2", "locus": { "chromosome": "16", "start_pos": 43675419, "end_pos": 43628175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005933", "url": "https://www.ensembl.org/id/ENSBTAG00000005933" } ] } } ], "crossref": [ { "id": "Q5E9N2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9N2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005933", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005933", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614630", "url": "https://www.ncbi.nlm.nih.gov/gene/614630", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614630", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614630", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNCEGAS", "url": "https://omabrowser.org/oma/group/MNCEGAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9N2", "url": "https://www.orthodb.org/?gene=Q5E9N2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47142:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47142:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06384", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06384", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3769402", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3769402", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF7AG29", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AG29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AG29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AG29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9N2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTANEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81, "header": "sp|Q5E9N2-1|CNBP1_BOVIN Isoform 1 of Beta-catenin-interacting protein 1 OS=Bos taurus OX=9913 GN=CTNNBIP1 PE=3 SV=1 CANONICAL=Q5E9N2-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AG29-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2/entry#A0AAF7AG29-1", "sequence": { "sequence": "LTEREAEAEAAAPAAAAAAAAVAAARAVRVPEQAAARRSRTRSPRPPGRVGRPRAASSYFSPATAHLSQLSIWLPQVDFQKQELQVCNPNPSTPGFLPTGSSWREETPGLLSRDLAAAGRVSTAPGRTATRRSHPVTAVPRAGQGMNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTANEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 226, "header": "tr|A0AAF7AG29-1|A0AAF7AG29_BOVIN Computationally mapped isoform of Beta-catenin-interacting protein 1 OS=Bos taurus OX=9913 GN=CTNNBIP1 PE=3 SV=1 CANONICAL=Q5E9N2-1" }, "locus": {} }, { "isoform_ac": "Q5E9N2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2/entry#Q5E9N2-1", "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTANEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81, "header": "sp|Q5E9N2-1|CNBP1_BOVIN Isoform 1 of Beta-catenin-interacting protein 1 OS=Bos taurus OX=9913 GN=CTNNBIP1 PE=3 SV=1 CANONICAL=Q5E9N2-1" }, "locus": { "chromosome": "16", "start_pos": 43674855, "end_pos": 43657440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077468.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077468.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068342.3", "url": "https://www.ensembl.org/id/ENSBTAP00000068342.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "site_lbl": "Ser59" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614630", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614630", "resource": "KEGG Pathway" }, { "id": "R-BTA-3769402", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3769402", "resource": "Reactome", "description": "Deactivation of the beta-catenin transactivating complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ADI4-1", "protein_name": "Beta-catenin-interacting protein 1", "gene_name": "CTNNBIP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81 }, "evidence": [ { "id": "Q5E9N2", "url": "https://omabrowser.org/oma/group/Q5E9N2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IKH6-1", "protein_name": "Beta-catenin-interacting protein 1", "gene_name": "Ctnnbip1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81 }, "evidence": [ { "id": "Q5E9N2", "url": "https://omabrowser.org/oma/group/Q5E9N2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9JJN6-1", "protein_name": "Beta-catenin-interacting protein 1", "gene_name": "Ctnnbip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81 }, "evidence": [ { "id": "Q5E9N2", "url": "https://omabrowser.org/oma/group/Q5E9N2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NSA3-1", "protein_name": "Beta-catenin-interacting protein 1", "gene_name": "CTNNBIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ", "length": 81 }, "evidence": [ { "id": "Q5E9N2", "url": "https://omabrowser.org/oma/group/Q5E9N2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "beta-catenin destruction complex", "id": "GO:0030877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030877", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "positive regulation of monocyte differentiation", "id": "GO:0045657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045657", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "negative regulation of protein-containing complex assembly", "id": "GO:0031333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell proliferation", "id": "GO:0048662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048662", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "positive regulation of osteoblast differentiation", "id": "GO:0045669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045669", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "regulation of vascular permeability involved in acute inflammatory response", "id": "GO:0002528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002528", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "negative regulation of transcription initiation by RNA polymerase II", "id": "GO:0060633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060633", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "negative regulation of mesenchymal cell proliferation", "id": "GO:0072201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072201", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "armadillo repeat domain binding", "id": "GO:0070016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070016", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "Q5E9N2", "url": "https://www.uniprot.org/uniprotkb/Q5E9N2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9N2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 81, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9N2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9N2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 59 ], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9S8-1", "uniprot_ac": "Q5E9S8", "uniprot_id": "CDIN1_BOVIN", "mass": { "chemical_mass": 32314.0, "monoisotopic_mass": 32314.0 }, "refseq": { "ac": "NP_001015668", "name": "CDAN1-interacting nuclease 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" }, "gene_names": [ { "name": "CDIN1", "type": "recommended", "evidence": [ { "id": "Q5E9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ] }, { "name": "C10H15orf41", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] }, { "name": "C15orf41", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] }, { "name": "CDIN1", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] }, { "name": "HH114", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] } ], "protein_names": [ { "name": "CDAN1-interacting nuclease 1", "type": "recommended", "evidence": [ { "id": "Q5E9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8/entry#names_and_taxonomy" } ] }, { "name": "CDAN1-interacting nuclease 1", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] }, { "name": "chromosome 10 C15orf41 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] }, { "name": "uncharacterized protein C15orf41 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015668", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668" } ] } ], "function": [ { "annotation": "Plays a role in erythroid cell differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8#function" }, { "database": "UniProtKB", "id": "Q9Y2V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y2V0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDIN1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8", "locus": { "chromosome": "10", "start_pos": 32520217, "end_pos": 32244014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002179", "url": "https://www.ensembl.org/id/ENSBTAG00000002179" } ] } } ], "crossref": [ { "id": "Q5E9S8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002179", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002179", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538758", "url": "https://www.ncbi.nlm.nih.gov/gene/538758", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538758", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538758", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYWNRFG", "url": "https://omabrowser.org/oma/group/CYWNRFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9S8", "url": "https://www.orthodb.org/?gene=Q5E9S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31661:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31661:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015668", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9S8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLHACFPTDIVTLCHSVA", "length": 281, "header": "sp|Q5E9S8-1|CDIN1_BOVIN Isoform 1 of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=2 SV=1 CANONICAL=Q5E9S8-1" }, "isoforms": [ { "isoform_ac": "Q5E9S8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8/entry#Q5E9S8-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLHACFPTDIVTLCHSVA", "length": 281, "header": "sp|Q5E9S8-1|CDIN1_BOVIN Isoform 1 of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=2 SV=1 CANONICAL=Q5E9S8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538758", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538758", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JLZ3-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "Cdin1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MILTKAQYEEIAQCLVSVPPTRQSLRKLKQRFPSSVHEHSNKWWLITQGKSQSQATLLSIFSQEYQKHIKRTHAKHHTPEAIESYYQRYLNGVGKNGAAPVLLELANEVDYAPSLMARIILERFLQGREQTPPSKSVINNMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGYEHEVLLRDLLLKKNLSFLDEDQLRAKGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHGQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLKACFPTDIVTLCHSTA", "length": 298 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZYC4-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "Cdin1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILTKAQYEEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTPEAIESYYQRYLSGVGKNGAAPVLLELANEVDYAPSLMARIILERFLQGHEQTPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGYEHEVLLRDLLLKKNLSFLDEDQLRAKGYDKTPDFILQVPVVMLCPLAVEGHIIHWIESKASFGDECSHHAYLHGQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLKASFPTDIVTLCHSTA", "length": 287 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08BW6-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "cdin1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDAVSGGSATGTGEQVNNLRICRAEYRSISRFVEQLRPTRQCMKTLQTHFTHLPASTLLSIFSQEYQKRMKRSMARHHSPEVLRVYYQRYRDEAETRATEPLLLELANQVDLSPALLARLMLECFLEERNASVPSRQVLNNMLREPYLIPDLVLAKHIEQCTVNDCCYGPLVDCIKHAIGLEHEDTLRDKLRERNLSFLDENQLRVKGYDKTPDIILEVPIAVDGHIVHWIESKASFGDDHSHNTYLNEQFWSYCNRFGPGLVIYWFGFISELDCQRERGILLKDGFPTDISSLCAGPQR", "length": 300 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3U4G0-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "Cdin1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILTKAQYEEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTPEAIESYYQRYLNGVGKNGAAPVLLELANEVDYAPSLMARIILERFLQGHEQTPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGYEHEVLLRDLLLKKNLSFLDEDQLRAKGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHGQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLKASFPTDIVTLCHSTA", "length": 281 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5F476-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "CDIN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKLTKAQYDEIAQFLGHVQPTRQSLRKLKEKFPSQSQSTLLSIFSQEYQKQIKRTHAKHHTAEAVETYYQRYLNGVMKNAAAPVLLELANEMDFAPSLMARIVLERFLQEQEQAIPSKTLINSMLRDPSQIPDGVLANQIYQCTVNDCCYGPLVDCIKHFINNRSCSLCVAEDQLRAKGYDKTPDFILEVPVAVEGHIIHWIESKASFGDESSHQAYLQDQFWSYWNRFGPGLVIYWYGFIEELDCHRERGILLKDCFPTDIVTLRHSMAQR", "length": 272 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9Y2V0-1", "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "CDIN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVVKNGAAPVLLDLANEVDYAPSLMARLILERFLQEHEETPPSKSIINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRAKGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLKACFPTNIVTLCHSIA", "length": 281 }, "evidence": [ { "id": "Q5E9S8", "url": "https://omabrowser.org/oma/group/Q5E9S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S8", "url": "https://www.uniprot.org/uniprotkb/Q5E9S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9S8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 281, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9S8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9S8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BKZ9-1", "uniprot_ac": "E1BKZ9", "uniprot_id": "E1BKZ9_BOVIN", "mass": { "chemical_mass": 96446.0, "monoisotopic_mass": 96446.0 }, "refseq": {}, "gene_names": [ { "name": "SORT1", "type": "recommended", "evidence": [ { "id": "E1BKZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ] } ], "protein_names": [ { "name": "Sortilin", "type": "recommended", "evidence": [ { "id": "E1BKZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9/entry#names_and_taxonomy" } ] }, { "name": "Neurotensin receptor 3", "type": "synonym", "evidence": [ { "id": "E1BKZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SORT1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9", "locus": { "chromosome": "3", "start_pos": 34101263, "end_pos": 34037024, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008849", "url": "https://www.ensembl.org/id/ENSBTAG00000008849" } ] } } ], "crossref": [ { "id": "E1BKZ9", "url": "https://alphafold.ebi.ac.uk/entry/E1BKZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006581", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006581", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FAPFYSV", "url": "https://omabrowser.org/oma/group/FAPFYSV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12106:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12106:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MFM8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAERPGSAYPRSAGLRLGGVARRLRGWAGAPGCRCPRRRHSAAMERPGGAADSLSRWPHGLGLLLFLLQLLPPATLGQDRLDAPPPPAAPLSRWSGPVGVSWGLRAAAPGGPAPRGGRWRRSAPGEDEDCGGVQDFVSRLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFVQTNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSENIIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWMKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYTFTKEPIYFTGLASEPGARSMNISIWGFTESFLARQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRNYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILATVGLMLVTVIAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTHKSGYHDDSDEDLLE", "length": 876, "header": "tr|E1BKZ9-1|E1BKZ9_BOVIN Isoform 1 of Sortilin OS=Bos taurus OX=9913 GN=SORT1 PE=3 SV=2 CANONICAL=E1BKZ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9/entry#A0A3Q1MFM8-1", "sequence": { "sequence": "MGAERPGSAYPRSAGLRLGGVARRLRGWAGAPGCRCPRRRHSAAMERPGGAADSLSRWPHGLGLLLFLLQLLPPATLGQDRLDAPPPPAAPLSRWSGPVGVSWGLRAAAPGGPAPRGGRWRRSAPGEDEDCGGVQDFVSRLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFVQTNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSENIIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWMKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYTFTKEPIYFTGLASEPGARSMNISIWGFTESFLARQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRNYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQDSRPQGHSLSQNPAPPPLGYTENTHSLSPTQKQNSKSNSVPIILATVGLMLVTVIAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTHKSGYHDDSDEDLLE", "length": 909, "header": "tr|A0A3Q1MFM8-1|E1BKZ9_BOVIN Computationally mapped isoform of Sortilin OS=Bos taurus OX=9913 GN=SORT1 PE=3 SV=1 CANONICAL=E1BKZ9-1" }, "locus": { "chromosome": "3", "start_pos": 34100259, "end_pos": 34037223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082768.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082768.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069332.1" } ] } }, { "isoform_ac": "E1BKZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9/entry#E1BKZ9-1", "sequence": { "sequence": "MGAERPGSAYPRSAGLRLGGVARRLRGWAGAPGCRCPRRRHSAAMERPGGAADSLSRWPHGLGLLLFLLQLLPPATLGQDRLDAPPPPAAPLSRWSGPVGVSWGLRAAAPGGPAPRGGRWRRSAPGEDEDCGGVQDFVSRLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFVQTNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSENIIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWMKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYTFTKEPIYFTGLASEPGARSMNISIWGFTESFLARQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRNYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILATVGLMLVTVIAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTHKSGYHDDSDEDLLE", "length": 876, "header": "tr|E1BKZ9-1|E1BKZ9_BOVIN Isoform 1 of Sortilin OS=Bos taurus OX=9913 GN=SORT1 PE=3 SV=2 CANONICAL=E1BKZ9-1" }, "locus": { "chromosome": "3", "start_pos": 34100259, "end_pos": 34037223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011652.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011652.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011652.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011652.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZV62-1", "protein_name": "Sortilin", "gene_name": "SORT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGPRGTARLTAAVAAVALAAALRTSPGGGPEEGGEGCGGLRGVTAVLGNNTHQCVFDDLSGSVSLSWVGDSTGVILVLTTFQVPWVIVISGQSKLYRSEDYGKTFKDITNLINNTFIRTEFGMAISPDNLGKVILTGDVSGGSRGGRIFRSSDFAKNFVQTELPFHPLAQISYHPQDSDRLLALSTDNGLWVSKDFGERWEQIHRAVCLAKWGANNTIFFTTYLNGSCKADLGFLELKKTTDFGKTFKVIGTKIYSFGLGGRFLFASVMTEKGFTRRIHVSLDQGESWSMAQLPSVGHEQFYSILAANDDLVFMHVDEPGDTGYGTIYTSDDRGVVYSKSLERHLYTTTGGETDFTNVTSLRGIYITSVLSEDNSIQSVITFDRGGEWVPLRKPKNTTCDSTARSREECSLHIHASYSISQKLNVPMVPLSEPNAIGIVIAHGSVGGAISVMSPDVYISDDGGYTWARMLEGPHHYAILDSGGLIVAIAHSSQPVNVLEFSTDEGQCWYRYTFTKEPIFFTGLASEPGARSMNVSIWGFRSSFLSRKWVSYTIDFSQLLSRSCEDEDYTIWLAHSSDPRDPSDGCILGYKEQFRRLRKSSVCQNGRDYAVTAQPSVCPCTLHDFLCDFGYYRPENQSVCVEQPELKGHDLEFCLYGRRELLRTSGYRKIPGDKCSGGESPSREETDMKKKCTSTLLSPGQLAASPDPTPIVLAVVAVLLVSAVAGVLLVKKYVCGGRFLVHRYSVLRQHAEASGAEGLETADPPSPPYKGGYHDDSDEDLLE", "length": 782 }, "evidence": [ { "id": "E1BKZ9", "url": "https://omabrowser.org/oma/group/E1BKZ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A5PMG8-1", "protein_name": "Sortilin", "gene_name": "sort1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRGLGHFIALLFFPMAFGVDFHVDPGSSNAHPLYAKSPVSVRSLLGTGSDADFSRVHHRIHKRSTDRGSDSCNGLTLEGYESKLTSNTHNWTFQDISGSVSLAWVGDGTGVVLALTTFQMPLVFLRFGQSKLYRSENYGKSFEDVSELINNTFINTDFGIAIGPENSGKVILTGDASGGSGARIFRSRDFGKSFVHTELPFHPLMQIMYNPQTTDVLAAISTKHDLWISKDFGTTWTKIHEMVCVVKWGIDALFFSTNLNGSCFDKGMLVLRKSVDLGANIKTVAERIYSFGIGGRFLFASVMAASGNIIPSASEEIMRAIHVSVDLGETWNMAQLPPVSHEQFYSILAANDDMVFMHVDEPGDTGIGTIYVSDDRGTVYSKSLERHLYTGGETDFTNVTSLRGVYTTSVLAEDNSVQTVITFDQGGEWVPLKKPENTKCDSTAKDAEMCSLHIHASYSTSMKVNVPMPPLSEPNAVGLILAHGSVGDAISMQTPDVYVSDDGGYTWLQALKGPHHYAILDSGGLLVAVEHNQAKPISEIKFSTDEGQCWHVHTFTQTPMYFTGLASEPGARSVNVSLWGYEDAMISHWVTYTIDFKDLLKRNCESDDYVQWLAHSDDISDPEDGCMLGYKERFLRVRKDSVCWIGREYVVNKQPTPCVCTLDDFLCDFGYYRKEKSSECIEQAELKGHDLEICIHGKKEQLQTSGYRKIPGDKCEGGKQPERKVIDLSKRCVSDLLDPQPLNNPQSEQSTSHTAPIIAMVIAILLTGLVFGALFVKKYVCGGRFLVHRYSVLQHNVEANGVDEPLETDVVGAPKNDFHDDSDEDLLE", "length": 828 }, "evidence": [ { "id": "E1BKZ9", "url": "https://omabrowser.org/oma/group/E1BKZ9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O54861-1", "protein_name": "Sortilin", "gene_name": "Sort1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLQKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFSQEPVYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEENDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSICPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDRCQGGMNPAREVKDLKKKCTSNFLNPKKQNSKSSSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVEALDTASHAKSGYHDDSDEDLLE", "length": 825 }, "evidence": [ { "id": "E1BKZ9", "url": "https://omabrowser.org/oma/group/E1BKZ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PHU5-1", "protein_name": "Sortilin", "gene_name": "Sort1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANEDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLRKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSVCPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDKCQGGMNPAREVKDLKKKCTSNFLNPTKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVEALDSTSHAKSGYHDDSDEDLLE", "length": 825 }, "evidence": [ { "id": "E1BKZ9", "url": "https://omabrowser.org/oma/group/E1BKZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99523-1", "protein_name": "Sortilin", "gene_name": "SORT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTNKSGYHDDSDEDLLE", "length": 831 }, "evidence": [ { "id": "E1BKZ9", "url": "https://omabrowser.org/oma/group/E1BKZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "nerve growth factor binding", "id": "GO:0048406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048406", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "neurotensin receptor activity, non-G protein-coupled", "id": "GO:0030379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030379", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "nerve growth factor receptor activity", "id": "GO:0010465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010465", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "retromer complex binding", "id": "GO:1905394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905394", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "trans-Golgi network transport vesicle", "id": "GO:0030140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030140", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "cerebellar climbing fiber to Purkinje cell synapse", "id": "GO:0150053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150053", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "maintenance of synapse structure", "id": "GO:0099558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099558", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "vesicle organization", "id": "GO:0016050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016050", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "Golgi to lysosome transport", "id": "GO:0090160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090160", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "neurotrophin TRK receptor signaling pathway", "id": "GO:0048011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048011", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "Golgi to endosome transport", "id": "GO:0006895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006895", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:0008625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "myotube differentiation", "id": "GO:0014902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "endosome transport via multivesicular body sorting pathway", "id": "GO:0032509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032509", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "plasma membrane to endosome transport", "id": "GO:0048227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048227", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "D-glucose import across plasma membrane", "id": "GO:0098708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098708", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" }, { "name": "protein transport into membrane raft", "id": "GO:0032596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032596", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ9", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 627, "end_pos": 629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 729, "end_pos": 731, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ9" }, { "id": "SM00602", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VPS10", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 790, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 627, "end_pos": 629 }, { "start_pos": 729, "end_pos": 731 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLC0-1", "uniprot_ac": "E1BLC0", "uniprot_id": "E1BLC0_BOVIN", "mass": { "chemical_mass": 38817.0, "monoisotopic_mass": 38817.0 }, "refseq": { "ac": "XP_002694189", "name": "guanidino acid hydrolase, mitochondrial isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694189" }, "gene_names": [ { "name": "AGMAT", "type": "recommended", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "name": "AGMAT", "type": "synonym", "evidence": [ { "id": "XP_002694189", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694189" } ] } ], "protein_names": [ { "name": "Guanidino acid hydrolase, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "3.5.3.17", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "3.5.3.1", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "3.5.3.7", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "Arginase, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "Guanidinobutyrase, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "Guanidinopropionase, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#names_and_taxonomy" } ] }, { "name": "guanidino acid hydrolase, mitochondrial isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002694189", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694189" } ] } ], "function": [ { "annotation": "Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N858", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "database": "UniProtKB", "id": "ARBA00060320", "url": "https://www.uniprot.org/uniprotkb/ARBA00060320#function" }, { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGMAT", "url": "https://www.uniprot.org/uniprotkb/E1BLC0", "locus": { "chromosome": "16", "start_pos": 51959275, "end_pos": 51949376, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002478", "url": "https://www.ensembl.org/id/ENSBTAG00000002478" } ] } } ], "crossref": [ { "id": "E1BLC0", "url": "https://alphafold.ebi.ac.uk/entry/E1BLC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002478", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002478", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11592", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514509", "url": "https://www.ncbi.nlm.nih.gov/gene/514509", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514509", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514509", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YELTTIM", "url": "https://omabrowser.org/oma/group/YELTTIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N858", "url": "https://www.orthodb.org/?gene=A0A3Q1N858", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLC0", "url": "https://www.orthodb.org/?gene=E1BLC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11358", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11358", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11358:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11358:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00491", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00491", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-351143", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351143", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002694189", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694189", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16029", "url": "https://www.rhea-db.org/rhea/16029", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19501", "url": "https://www.rhea-db.org/rhea/19501", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20569", "url": "https://www.rhea-db.org/rhea/20569", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "75931", "url": "https://www.rhea-db.org/rhea/75931", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N858", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N858-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRLLASTCARGLGGRGGSRRLVSRGRARPVAGLCDPSRRLSRQASDAPRNQPPSPEFVARSVGICSMMRLPVQATPEGLDAAFVGVPLDIGTSNRPGARFGPRRIREESVLLRTTNPSTGAVPFQFLRVADLGDVNVNLYNLQDSCRLIRADYQKIVAAGCVPLTLGGDHTITYPILQAIAEKHGPVGLVHVDAHMDMADKALGEKLYHGTPFRRCVDEGLLDCKRVVQIGIRGSSTTLDTYRYSRSQGFRVVLAEDCWLKSLVPLMGEVRQQMGGRPIYISFDIDGLDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDPSGNTALVAANLLFEMLCVLPKVTVA", "length": 361, "header": "tr|E1BLC0-1|E1BLC0_BOVIN Isoform 1 of Guanidino acid hydrolase, mitochondrial OS=Bos taurus OX=9913 GN=AGMAT PE=1 SV=1 CANONICAL=E1BLC0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N858-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#A0A3Q1N858-1", "sequence": { "sequence": "MLRLLASTCARGLGGRGGSRRLVSRGRARPVAGLCDPSRRLSRQASDAPRNQPPSPEFVARSVGICSMMRLPVQATPEGLDAAFVGVPLDIGTSNRPGARFGPRRIREESVLLRTTNPSTGAVPFQFLRVADLGDVNVNLYNLQDSCRLIRADYQKIVAAGCVPLTLGGDHTITYPILQAIAEKHGPVGLVHVDAHMDMADKALGEKLYHGTPFRRCVDEGLLDCKRVVQIGIRGSSTTLDTYRYSRSQGFRVVLAEDCWLKSLVPLMGEVRQQMGGRPIYISFDIDGLDPAYAPGTGTPEIAGLTPSQKGGWSYLPLSKPFLVPASFLEHTPFLCFACFQLFTCKMEALEIIRGCQGLNVVGCDLVEVSPPYDPSGNTALVAANLLFEMLCVLPKVTVA", "length": 400, "header": "tr|A0A3Q1N858-1|E1BLC0_BOVIN Computationally mapped isoform of Guanidino acid hydrolase, mitochondrial OS=Bos taurus OX=9913 GN=AGMAT PE=1 SV=1 CANONICAL=E1BLC0-1" }, "locus": { "chromosome": "16", "start_pos": 51958271, "end_pos": 51949575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085149.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085149.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067134.1" } ] } }, { "isoform_ac": "E1BLC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC0/entry#E1BLC0-1", "sequence": { "sequence": "MLRLLASTCARGLGGRGGSRRLVSRGRARPVAGLCDPSRRLSRQASDAPRNQPPSPEFVARSVGICSMMRLPVQATPEGLDAAFVGVPLDIGTSNRPGARFGPRRIREESVLLRTTNPSTGAVPFQFLRVADLGDVNVNLYNLQDSCRLIRADYQKIVAAGCVPLTLGGDHTITYPILQAIAEKHGPVGLVHVDAHMDMADKALGEKLYHGTPFRRCVDEGLLDCKRVVQIGIRGSSTTLDTYRYSRSQGFRVVLAEDCWLKSLVPLMGEVRQQMGGRPIYISFDIDGLDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDPSGNTALVAANLLFEMLCVLPKVTVA", "length": 361, "header": "tr|E1BLC0-1|E1BLC0_BOVIN Isoform 1 of Guanidino acid hydrolase, mitochondrial OS=Bos taurus OX=9913 GN=AGMAT PE=1 SV=1 CANONICAL=E1BLC0-1" }, "locus": { "chromosome": "16", "start_pos": 51958271, "end_pos": 51949575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044729.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044729.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042200.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042200.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514509", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514509", "resource": "KEGG Pathway" }, { "id": "R-BTA-351143", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351143", "resource": "Reactome", "description": "Agmatine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZGB9-1", "protein_name": "Agmatinase", "gene_name": "AGMAT", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSCLLRTARLSAQLLFASAAAPCRRASRFNVPPSAEFVARPVGVCSMLRLPVQTSAEGLDAAFVGVPLDTGTSNRPGARFGPQQIRAESVMVRRYNASTGAAPFDSLLVADVGDVNVNLYNLPDSCRRIRESYQKIVASGCVPLTLGGDHSITYPILQAVAEKHGPVGLVHVDAHTDTSDMALGEKIYHGTPFRRCVDEGLLDCSRVVQIGIRGSSYAPNPYKYCWDQGFRVVPAEECWMKSLVPLMGEVRQQMGDGPVYISFDIDGLDPAYAPGTGTPEIAGLTPMQALEIIRGCKGLNIVGCDLVEVAPIYDVSGNTALLGANLLFEMLCVLPGVKTMCSDRLLCSKE", "length": 350 }, "evidence": [ { "id": "E1BLC0", "url": "https://omabrowser.org/oma/group/E1BLC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2AS89-1", "protein_name": "Guanidino acid hydrolase, mitochondrial", "gene_name": "Agmat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRLLRSSWARGLGSGVATWRPSAGLFRPGCPGIRQASGASDTPHHQSPSSESPVQPVGVGVCSMMRLPLQSSPEGLDAAFIGVPLDTGTSNRPGARFGPCRIREESLMLGAVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCLLIREAYQNVLAAGCIPLTLGGDQTITYPILQAVAKEHGPVGLVHVGAHTNTTDKPREEKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEVRQQMGGKPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV", "length": 358 }, "evidence": [ { "id": "E1BLC0", "url": "https://omabrowser.org/oma/group/E1BLC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q0D2L3-1", "protein_name": "Guanidino acid hydrolase, mitochondrial", "gene_name": "Agmat", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQLLKSSWVRSAGSGVVTWRASAGLFCPGTRQASDTSDTLHHPSPSSESQVQPVRVCSMMHLPLQSSPEGLDAAFVGVPLDTGTSNRPGARFGPRRIREESLMLGTVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCRLIREAYQNILATGCIPLTLGGDHTITYPILQAVAKEHGPVGLVHVGAHSNTSDKPLEDKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEIRQQMGGVPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV", "length": 353 }, "evidence": [ { "id": "E1BLC0", "url": "https://omabrowser.org/oma/group/E1BLC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BSE5-1", "protein_name": "Guanidino acid hydrolase, mitochondrial", "gene_name": "AGMAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMMRLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV", "length": 352 }, "evidence": [ { "id": "E1BLC0", "url": "https://omabrowser.org/oma/group/E1BLC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" }, { "name": "arginase activity", "id": "GO:0004053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004053", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" }, { "name": "agmatinase activity", "id": "GO:0008783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008783", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" }, { "name": "guanidinobutyrase activity", "id": "GO:0047971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047971", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" }, { "name": "guanidinopropionase activity", "id": "GO:0047972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047972", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "putrescine biosynthetic process from arginine, via agmatine", "id": "GO:0033389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033389", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" }, { "name": "arginine metabolic process", "id": "GO:0006525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006525", "evidence": [ { "database": "UniProtKB", "id": "E1BLC0", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16029", "name": "", "equation": "3-guanidinopropanoate + H2O = urea + beta-alanine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BLC0-1" ], "evidence": [ { "id": "16029", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16029" } ] }, { "id": "19501", "name": "", "equation": "4-guanidinobutanoate + H2O = urea + 4-aminobutanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BLC0-1" ], "evidence": [ { "id": "19501", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19501" } ] }, { "id": "20569", "name": "", "equation": "L-arginine + H2O = urea + L-ornithine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3MWN1-1", "Q58DL1-1", "Q2KJ64-1", "E1BLC0-1" ], "evidence": [ { "id": "20569", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20569" } ] }, { "id": "75931", "name": "", "equation": "taurocyamine + H2O = urea + taurine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BLC0-1" ], "evidence": [ { "id": "75931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75931" } ] }, { "id": "R-BTA-350604", "name": "Agmatine + H2O <=> putrescine + urea", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BLC0-1" ], "evidence": [ { "id": "R-BTA-350604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350604" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BLC0", "gene_name": "AGMAT", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "ec_number": "3.5.3.17", "activity": "4-guanidinobutanoate + H2O = urea + 4-aminobutanoate.", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "ec_number": "3.5.3.7", "activity": "4-guanidinobutanoate + H2O = urea + 4-aminobutanoate.", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "ec_number": "3.5.3.7", "activity": "", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] }, { "ec_number": "3.5.3.17", "activity": "", "evidence": [ { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "Q2KJ64", "gene_name": "ARG1", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] } ] }, { "uniprot_ac": "Q58DL1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLC0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 171, "amino_acid": "His", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 171, "end_pos": 171, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 194, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 194, "end_pos": 194, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 196, "amino_acid": "His", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 196, "end_pos": 196, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 198, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 198, "end_pos": 198, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 285, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 285, "end_pos": 285, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858#function" }, { "id": "A0A3Q1N858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N858" }, { "id": "PIRSR036979-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR036979-1" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0#function" }, { "id": "E1BLC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLC0" } ], "binding_site_uniprot": 287, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 287, "end_pos": 287, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.3.1", "ec_name": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "3.5.3.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1" }, { "id": "3.5.3.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.3.1" } ] }, { "ec_number": "3.5.3.17", "ec_name": "4-guanidinobutanoate + H2O = urea + 4-aminobutanoate.", "evidence": [ { "id": "3.5.3.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17" } ] }, { "ec_number": "3.5.3.7", "ec_name": "4-guanidinobutanoate + H2O = urea + 4-aminobutanoate.", "evidence": [ { "id": "3.5.3.7", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7" }, { "id": "3.5.3.7", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.3.7" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q76I82-1", "uniprot_ac": "Q76I82", "uniprot_id": "RS15A_BOVIN", "mass": { "chemical_mass": 14840.0, "monoisotopic_mass": 14840.0 }, "refseq": { "ac": "NP_001032520", "name": "small ribosomal subunit protein uS8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032520" }, "gene_names": [ { "name": "RPS15A", "type": "recommended", "evidence": [ { "id": "Q76I82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ] }, { "name": "RPS15A", "type": "synonym", "evidence": [ { "id": "NP_001032520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032520" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein uS8", "type": "recommended", "evidence": [ { "id": "Q76I82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76I82/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S15a", "type": "synonym", "evidence": [ { "id": "NP_001032520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032520" }, { "id": "Q76I82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76I82/entry#names_and_taxonomy" } ] }, { "name": "small ribosomal subunit protein uS8", "type": "synonym", "evidence": [ { "id": "NP_001032520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032520" } ] } ], "function": [ { "annotation": "Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis.", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82#function" }, { "database": "UniProtKB", "id": "P62244", "url": "https://www.uniprot.org/uniprotkb/P62244#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS15A", "url": "https://www.uniprot.org/uniprotkb/Q76I82", "locus": { "chromosome": "25", "start_pos": 16423491, "end_pos": 16429311, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020733", "url": "https://www.ensembl.org/id/ENSBTAG00000020733" } ] } } ], "crossref": [ { "id": "Q76I82", "url": "https://alphafold.ebi.ac.uk/entry/Q76I82", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020733", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020733", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000053164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "337888", "url": "https://www.ncbi.nlm.nih.gov/gene/337888", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:337888", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337888", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGDMEKW", "url": "https://omabrowser.org/oma/group/IGDMEKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "KKGKCQV", "url": "https://omabrowser.org/oma/group/KKGKCQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q76I82", "url": "https://www.orthodb.org/?gene=Q76I82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032520", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N943", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N943", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N943-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N943-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q76I82-1", "url": "https://www.uniprot.org/uniprotkb/Q76I82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130, "header": "sp|Q76I82-1|RS15A_BOVIN Isoform 1 of Small ribosomal subunit protein uS8 OS=Bos taurus OX=9913 GN=RPS15A PE=2 SV=1 CANONICAL=Q76I82-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N943-1", "url": "https://www.uniprot.org/uniprotkb/Q76I82/entry#A0A3Q1N943-1", "sequence": { "sequence": "MVHMNVLADVLKSINNAKKKGKCQVLIRPCSKVIVKFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGAISPRFDVQLKDLEKWQNKLLPSYQLGFIVLTTSAGIMDHEAARRKHTGGKILGFFF", "length": 130, "header": "tr|A0A3Q1N943-1|RS15A_BOVIN Computationally mapped isoform of Small ribosomal subunit protein uS8 OS=Bos taurus OX=9913 GN=RPS15A PE=2 SV=1 CANONICAL=Q76I82-1" }, "locus": { "chromosome": "20", "start_pos": 3252756, "end_pos": 3252367, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079304.1", "url": "https://www.ensembl.org/id/ENSBTAT00000079304.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067640.1" } ] } }, { "isoform_ac": "Q76I82-1", "url": "https://www.uniprot.org/uniprotkb/Q76I82/entry#Q76I82-1", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130, "header": "sp|Q76I82-1|RS15A_BOVIN Isoform 1 of Small ribosomal subunit protein uS8 OS=Bos taurus OX=9913 GN=RPS15A PE=2 SV=1 CANONICAL=Q76I82-1" }, "locus": { "chromosome": "25", "start_pos": 16428241, "end_pos": 16423528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027627.3", "url": "https://www.ensembl.org/id/ENSBTAT00000027627.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000027627.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray.", "journal": "Mol. Reprod. Dev.", "date": "2003", "authors": "Ishiwata Hiroko, Katsuma Susumu, Kizaki Keiichiro, Patel Osman V, Nakano Hiroko, Takahashi Toru, Imai Kei, Hirasawa Akira, Shiojima Satoshi, Ikawa Hiroshi, Suzuki Yasuhito, Tsujimoto Gozoh, Izaike Yoshiaki, Todoroki Junichi, Hashizume Kazuyoshi", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "reference": [ { "type": "PubMed", "id": "12658628", "url": "https://glygen.org/publication/PubMed/12658628" } ] } ], "pathway": [ { "id": "bta:337888", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337888", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3A7P6-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "RPS15A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGYIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2LFI3-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "LOC107980368", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVHMNVLADALKSINNAEKRGKCQVLIRPCSKVISGFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRVNKCGVISPRFNVQLKDLEKWQNNLLRSSQFGFIVLTTSAAIMDHEEARQKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A2Q0-1", "protein_name": "Fibronectin type III domain-containing protein 10", "gene_name": "Fndc10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRAPPLLLLLAACAPPSGAAVDPTPPGWEPAPDAPWCPYKVLSEGPEAGGGRLCFRSPVRGFRCQTPGCVTLASAGGSLRAHVLRNRSVLLQWRLAPAEARRVRVFALNCSWRGTYTRFPCDRVLLGASCRDYLLPDVHDSVRYRLCLQPLPLPLRAELAAAPPELAECVEFTAEPAAMQEIVVAMTAVGGSICVMLVVICLLVAYITENLMHPTFRRPSLRRQP", "length": 225 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IKE2-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C0W1-1", "protein_name": "Small ribosomal subunit protein uS8A", "gene_name": "RPS22A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTRSSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLQVMQKHGYIGEFEYIDDHRSGKIVVQLNGRLNKCGVISPRFNVKIGDIEKWTANLLPARQFGYVILTTSAGIMDHEEARRKHVSGKILGFVY", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P42798-1", "protein_name": "Small ribosomal subunit protein uS8z/uS8w", "gene_name": "RPS15AF", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVRISVLNDALKSMYNAEKRGKRQVMIRPSSKVIIKFLIVMQKHGYIGEFEYVDDHRSGKIVVELNGRLNKCGVISPRFDVGVKEIEGWTARLLPSRQFGYIVLTTSAGIMDHEEARRKNVGGKVLGFFY", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" }, { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P46793-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "rps15a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVRISVLNDCLNSIVNAERQGKRQVLVRPSSKVIVKFLEVMMKKRYIGEFEIVDDHRSGKIVIDLIGRINKCGVISPRFDVTLDEIEKWASYLLPSRQFGHIVLTTSLGIMDHNEAKTRHTGGKLLGFFY", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P48149-1", "protein_name": "Small ribosomal subunit protein uS8A", "gene_name": "RpS15Aa", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVRMNVLADALKCINNAEKRGKRQVLLRPCSKVIIKFLTVMMKHGYIGEFEIVDDHRSGKIVVNLTGRLNKCGVISPRFDVPINDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P62244-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "RPS15A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62245-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62246-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" }, { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6Q420-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "rps15a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLLRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7KR04-1", "protein_name": "Small ribosomal subunit protein uS8B", "gene_name": "RpS15Ab", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVRMNVLADALKCINNAEKRGKRQVLLRPCSKVIIKFLTVMMKHGYIGEFEIVEDHRAGKIVVNLTGRLNKCGVISPRFDAPINDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF", "length": 130 }, "evidence": [ { "id": "Q76I82", "url": "https://omabrowser.org/oma/group/Q76I82/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" }, { "name": "positive regulation of cell cycle", "id": "GO:0045787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045787", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q76I82", "url": "https://www.uniprot.org/uniprotkb/Q76I82" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q76I82-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 130, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q76I82-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q76I82" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BK45-1", "uniprot_ac": "E1BK45", "uniprot_id": "E1BK45_BOVIN", "mass": { "chemical_mass": 24137.0, "monoisotopic_mass": 24137.0 }, "refseq": { "ac": "XP_002688806", "name": "retbindin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688806" }, "gene_names": [ { "name": "RTBDN", "type": "recommended", "evidence": [ { "id": "E1BK45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ] }, { "name": "RTBDN", "type": "synonym", "evidence": [ { "id": "XP_002688806", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688806" } ] } ], "protein_names": [ { "name": "Retbindin", "type": "synonym", "evidence": [ { "id": "E1BK45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK45/entry#names_and_taxonomy" } ] }, { "name": "retbindin", "type": "synonym", "evidence": [ { "id": "XP_002688806", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688806" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTBDN", "url": "https://www.uniprot.org/uniprotkb/E1BK45", "locus": { "chromosome": "7", "start_pos": 12714768, "end_pos": 12712003, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006077", "url": "https://www.ensembl.org/id/ENSBTAG00000006077" } ] } } ], "crossref": [ { "id": "E1BK45", "url": "https://alphafold.ebi.ac.uk/entry/E1BK45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "784508", "url": "https://www.ncbi.nlm.nih.gov/gene/784508", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784508", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784508", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ESDITCG", "url": "https://omabrowser.org/oma/group/ESDITCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NCZ3", "url": "https://www.orthodb.org/?gene=A0A3Q1NCZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BK45", "url": "https://www.orthodb.org/?gene=E1BK45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10517:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10517:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688806", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688806", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCZ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK45-1", "url": "https://www.uniprot.org/uniprotkb/E1BK45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACRGRTRPRALAWALQLTLAWMLLGACGGSHPLPARSQRHYRLATNLGTDQLHLEEMNPPEASDSGLVPVRCGELSPRCESFLVHLQAALRSRFHLVLLGVRQTQPLCSELCDAWFATCESDVICSPTWLPLLEKRGCEPGCTTYRQTFADGAELCRSLLGDALPVADPGSGHCLNISVSMLPRPRRARRSRGTVFPRSRRSRTGILDSASSGSGSGSGSGP", "length": 223, "header": "tr|E1BK45-1|E1BK45_BOVIN Isoform 1 of Retbindin OS=Bos taurus OX=9913 GN=RTBDN PE=3 SV=3 CANONICAL=E1BK45-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NCZ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BK45/entry#A0A3Q1NCZ3-1", "sequence": { "sequence": "MACRGRTRPRALAWALQLTLAWMLLGACGGSHPLPARSQRHYRLATNLGTDQLHLEGKHSRLSEPQVSTPTSGVSLGSLLQLPQLGAKALEHPDLSVLSLSMSRCESFLVHLQAALRSRFHLVLLGVRQTQPLCSELCDAWFATCESDVICSPTWLPLLEKRGCEPGCTTYRQTFADGAELCRSLLGDALPVADPGSGHCLNISVSMLPRPRRARRSRGTVFPRSRRSRTGILDSASSGSGSGSGSGP", "length": 248, "header": "tr|A0A3Q1NCZ3-1|E1BK45_BOVIN Computationally mapped isoform of Retbindin OS=Bos taurus OX=9913 GN=RTBDN PE=3 SV=1 CANONICAL=E1BK45-1" }, "locus": { "chromosome": "7", "start_pos": 12714555, "end_pos": 12712003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069313.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069313.1" } ] } }, { "isoform_ac": "E1BK45-1", "url": "https://www.uniprot.org/uniprotkb/E1BK45/entry#E1BK45-1", "sequence": { "sequence": "MACRGRTRPRALAWALQLTLAWMLLGACGGSHPLPARSQRHYRLATNLGTDQLHLEEMNPPEASDSGLVPVRCGELSPRCESFLVHLQAALRSRFHLVLLGVRQTQPLCSELCDAWFATCESDVICSPTWLPLLEKRGCEPGCTTYRQTFADGAELCRSLLGDALPVADPGSGHCLNISVSMLPRPRRARRSRGTVFPRSRRSRTGILDSASSGSGSGSGSGP", "length": 223, "header": "tr|E1BK45-1|E1BK45_BOVIN Isoform 1 of Retbindin OS=Bos taurus OX=9913 GN=RTBDN PE=3 SV=3 CANONICAL=E1BK45-1" }, "locus": { "chromosome": "7", "start_pos": 12714555, "end_pos": 12712003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007986.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007986.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007986.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007986.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784508", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784508", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TGT2-1", "protein_name": "Retbindin", "gene_name": "RTBDN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACRGRTRPRGLAWALQLTLAWILLGACGGSHPLPARSRRHHQLAADLGTVQLHQGSTRPWFPNAMMMQDRNSQDFPSLWPSCPSAMDTSEVSGLGISAESCGELSPRCESFLGHLQVALRSRFHLLLLGVLQTQPLCSELCDAWFATCESDFTCSSTWLPLVEKRGCKPICSTYGQTFADGAGLCRSVLGYVLPVADPGSSPCLNISISVLSRPRHARRARETTFPRSRRPRTLILDAAGSGSGSGSGSGP", "length": 252 }, "evidence": [ { "id": "E1BK45", "url": "https://omabrowser.org/oma/group/E1BK45/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZWD2-1", "protein_name": "Retbindin", "gene_name": "Rtbdn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHEGHFQHSGMVWALRLILAWVFLVTCGGSHPLQARSWGHPGLAANVSTGQLQLAGHPQSSVPPSYPRIQVPSSQTPATPEPCCTADIDRPEASNPESLLASCGAPSPECEFFLGHLQRALRGRFHPLLFGVRRMQPLCMELCQIWFTTCQADFICGPTWLQSSGKRGCEPSCRTYGQTFANATDLCHSALGHALRVAAPGSSHCFNISISSPGARRRPRAWISNVAGSGSGSGSGDSPE", "length": 241 }, "evidence": [ { "id": "E1BK45", "url": "https://omabrowser.org/oma/group/E1BK45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8QZY4-1", "protein_name": "Retbindin", "gene_name": "Rtbdn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAHEGHSQHSGLVWALRPILAWIFLVACGWSHPLQTRSWGHPGLAAKVRTGQLQPAGHPQSSVLPSYPRIQVPGSQTPPVPVPCCTAEIDRPESLLESCGAPSPECEFFLGQLQGALRDRFHPQLFGARPVQPLCPELCQIWFTTCQADFICGPTWLQSSGERGCEPSCRTYGQTFANATDLCHSVLGHVLRVAAPGSSHCLNVSISSPGARRRPRAWISNVVGSGSGSGSGDSPEPMFGFQYVSLP", "length": 247 }, "evidence": [ { "id": "E1BK45", "url": "https://omabrowser.org/oma/group/E1BK45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BSG5-1", "protein_name": "Retbindin", "gene_name": "RTBDN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDCRVHMRPIGLTWVLQLTLAWILLEACGGSRPLQARSQQHHGLAADLGKGKLHLAGPCCPSEMDTTETSGPGNHPERCGVPSPECESFLEHLQRALRSRFRLRLLGVRQAQPLCEELCQAWFANCEDDITCGPTWLPLSEKRGCEPSCLTYGQTFADGTDLCRSALGHALPVAAPGARHCFNISISAVPRPRPGRRGREAPSRRSRSPRTSILDAAGSGSGSGSGSGP", "length": 229 }, "evidence": [ { "id": "E1BK45", "url": "https://omabrowser.org/oma/group/E1BK45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "riboflavin transmembrane transporter activity", "id": "GO:0032217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032217", "evidence": [ { "database": "UniProtKB", "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ], "pmid": "" }, { "name": "riboflavin binding", "id": "GO:1902444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902444", "evidence": [ { "database": "UniProtKB", "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "E1BK45", "url": "https://www.uniprot.org/uniprotkb/E1BK45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK45" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BK45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK45" }, { "id": "PF03024", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Folate receptor-like", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 177, "start_aa": "Gly", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL00-1", "uniprot_ac": "E1BL00", "uniprot_id": "E1BL00_BOVIN", "mass": { "chemical_mass": 105072.0, "monoisotopic_mass": 105072.0 }, "refseq": {}, "gene_names": [ { "name": "PWP2", "type": "recommended", "evidence": [ { "id": "E1BL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ] } ], "protein_names": [ { "name": "Periodic tryptophan protein 2 homolog", "type": "recommended", "evidence": [ { "id": "E1BL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL00/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00#function" }, { "database": "UniProtKB", "id": "ARBA00035000", "url": "https://www.uniprot.org/uniprotkb/ARBA00035000#function" }, { "database": "UniProtKB", "id": "A0A3Q1NJ83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ83#function" }, { "database": "UniProtKB", "id": "A0AAA9RYT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PWP2", "url": "https://www.uniprot.org/uniprotkb/E1BL00", "locus": { "chromosome": "1", "start_pos": 144148079, "end_pos": 144133981, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007105", "url": "https://www.ensembl.org/id/ENSBTAG00000007105" } ] } } ], "crossref": [ { "id": "E1BL00", "url": "https://alphafold.ebi.ac.uk/entry/E1BL00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007105", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VYEWQSE", "url": "https://omabrowser.org/oma/group/VYEWQSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJ83", "url": "https://www.orthodb.org/?gene=A0A3Q1NJ83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BL00", "url": "https://www.orthodb.org/?gene=E1BL00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19858", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19858", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19858:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19858:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04003", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04003", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NJ83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJ83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL00-1", "url": "https://www.uniprot.org/uniprotkb/E1BL00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALPPRKCLLRAEGRGAETASNTRVAAGMKFAYRFSNLLGTVYRCGNLNFTCDGNSVISPVGNRVTVFDLKNNKSNTLPLATRYNIKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGAVHSVSFSPDGRKFVVTKGNIAQVYHAPGRKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFAVGSRDMSTWVFGAERWDNLIYYALGGHKDAIVACFFEASSLDLYTLSQDGALCVWQCDTLPEGLRLKAPTGWKADLLQREEEQEEEEGAESETTIRGKATPAAEEQQGKVKYSRVAKYFFNKEGDFNNLTAAAYHKKVHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNSLSGFCFVTFTEHSSGVTGVTFTTTGYVIVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEVFIWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDRTVHLWDMADSWRTTETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCIYHVREQILRKKFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAAEEGGVAIPLPSVKKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDAQMLFDPFELDTSVTPVRIRAALRQRDFTRAILLAFRLNERKLLQETLEAVPWDEIEVISSSLPDLYVEKVLEFLASSFEVSHHLEFYLIWTQKLLMVHGQKLKSRVGTLLPAVQFLQKSIQRHLDDVSKLCDWNRYNLQYALAVSKQRGLKRPSEPLGSEEEAGASEDDDDDSLHLLGGGPGHADAPLA", "length": 948, "header": "tr|E1BL00-1|E1BL00_BOVIN Isoform 1 of Periodic tryptophan protein 2 homolog OS=Bos taurus OX=9913 GN=PWP2 PE=3 SV=3 CANONICAL=E1BL00-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJ83-1", "url": "https://www.uniprot.org/uniprotkb/E1BL00/entry#A0A3Q1NJ83-1", "sequence": { "sequence": "MKFAYRRATCVSGAVSVCAALPAAATALKAVLPQFSNLLGTVYRCGNLNFTCDGNSVISPVGNRVTVFDLKNNKSNTLPLATRYNIKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGAVHSVSFSPDGRKFVVTKGNIAQVYHAPGRKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFAVGSRDMSTWVFGAERWDNLIYYALGGHKDAIVACFFEASSLDLYTLSQDGALCVWQCDTLPEGLRLKAPTGWKADLLQREEEQEEEEGAESETTIRGKATPAAEEQQGKVKYSRVAKYFFNKEGDFNNLTAAAYHKKVHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNSLSGFCFVTFTEHSSGVTGVTFTTTGYVIVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEVFIWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDRTVHLWDMADSWRTTETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCIYHVREQILRKKFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAAEEGGVAIPLPSVKKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDAQMLFDPFELDTSVTPVRIRAALRQRDFTRAILLAFRLNERKLLQETLEAVPWDEIEVISSSLPDLYVEKVLEFLASSFEVSHHLEFYLIWTQKLLMVHGQKLKSRVGTLLPAVQFLQKSIQRHLDDVSKLCDWNRYNLQYALAVSKQRGLKRPSEPLGSEEEAGASEDDDDDSLHLLGGGPGHADAPLA", "length": 947, "header": "tr|A0A3Q1NJ83-1|E1BL00_BOVIN Computationally mapped isoform of Periodic tryptophan protein 2 homolog OS=Bos taurus OX=9913 GN=PWP2 PE=3 SV=1 CANONICAL=E1BL00-1" }, "locus": { "chromosome": "1", "start_pos": 144147075, "end_pos": 144134157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078536.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078536.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072174.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072174.1" } ] } }, { "isoform_ac": "A0AAA9RYT2-1", "url": "https://www.uniprot.org/uniprotkb/E1BL00/entry#A0AAA9RYT2-1", "sequence": { "sequence": "MFKTHFNKSNTLPLATRYNIKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGAVHSVSFSPDGRKFVVTKGNIAQVYHAPGRKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFAVGSRDMSTWVFGAERWDNLIYYALGGHKDAIVACFFEASSLDLYTLSQDGALCVWQCDTLPEGLRLKAPTGWKADLLQREEEQEEEEGAESETTIRGKATPAAEEQQGKVKYSRVAKYFFNKEGDFNNLTAAAYHKKVHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNSLSGFCFVTFTEHSSGVTGVTFTTTGYVIVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEVFIWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDRTVHLWDMADSWRTTETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCIYHVREQILRKKFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAAEEGGVAIPLPSVKKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDAQMLFDPFELDTSVTPVRIRAALRQRDFTRAILLAFRLNERKLLQETLEAVPWDEIEVISSSLPDLYVEKVLEFLASSFEVSHHLEFYLIWTQKLLMVHGQKLKSRVGTLLPAVQFLQKSIQRHLDDVSKLCDWNRYNLQYALAVSKQRGLKRPSEPLGSEEEAGASEDDDDDSLHLLGGGPGHADAPLA", "length": 881, "header": "tr|A0AAA9RYT2-1|A0AAA9RYT2_BOVIN Computationally mapped isoform of Periodic tryptophan protein 2 homolog OS=Bos taurus OX=9913 GN=PWP2 PE=3 SV=1 CANONICAL=E1BL00-1" }, "locus": { "chromosome": "1", "start_pos": 144147075, "end_pos": 144136339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107991.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107991.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078731.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078731.1" } ] } }, { "isoform_ac": "E1BL00-1", "url": "https://www.uniprot.org/uniprotkb/E1BL00/entry#E1BL00-1", "sequence": { "sequence": "MAALPPRKCLLRAEGRGAETASNTRVAAGMKFAYRFSNLLGTVYRCGNLNFTCDGNSVISPVGNRVTVFDLKNNKSNTLPLATRYNIKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGAVHSVSFSPDGRKFVVTKGNIAQVYHAPGRKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFAVGSRDMSTWVFGAERWDNLIYYALGGHKDAIVACFFEASSLDLYTLSQDGALCVWQCDTLPEGLRLKAPTGWKADLLQREEEQEEEEGAESETTIRGKATPAAEEQQGKVKYSRVAKYFFNKEGDFNNLTAAAYHKKVHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNSLSGFCFVTFTEHSSGVTGVTFTTTGYVIVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEVFIWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDRTVHLWDMADSWRTTETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCIYHVREQILRKKFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAAEEGGVAIPLPSVKKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDAQMLFDPFELDTSVTPVRIRAALRQRDFTRAILLAFRLNERKLLQETLEAVPWDEIEVISSSLPDLYVEKVLEFLASSFEVSHHLEFYLIWTQKLLMVHGQKLKSRVGTLLPAVQFLQKSIQRHLDDVSKLCDWNRYNLQYALAVSKQRGLKRPSEPLGSEEEAGASEDDDDDSLHLLGGGPGHADAPLA", "length": 948, "header": "tr|E1BL00-1|E1BL00_BOVIN Isoform 1 of Periodic tryptophan protein 2 homolog OS=Bos taurus OX=9913 GN=PWP2 PE=3 SV=3 CANONICAL=E1BL00-1" }, "locus": { "chromosome": "1", "start_pos": 144147075, "end_pos": 144134070, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009343.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009343.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009343.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009343.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A481CKZ1-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "PWP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKFAYRFSNLLGTVYRCGNLNFTCDGNSLISPVGNRVTVFDLKNNKSDTLPLATRYNIKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGAVHSVAFSPDGRKFVVTKGNGAQLYHAPGRRREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALGGHRDAIVACFFEADSLDVYTLSQDGALCVWQCDTPPAGLRLKAPSGWRADLQRREGDEDEEDNEEEERAVRGKAAPAAEEQQGKVRYSRLAKYFFNKEGDFNNLTAAAYHKKVHLLVTGFASGMFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNTLSGFCFITFTEHSSGVTGVTFTATGYVIVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDTSGEVVAAGAQDSFEIFIWSMQTGRLLDVLSGHEGPISGLCFNPTKSVLASASWDRTVRLWDMADSWRTTETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKSGRKELDKITAKHSAKGKAFTALCYSADGQSVLAGGRSKFVCIYHVREQILRKRFEISGNLSLDAMEEFLNRRKMTEFGNLALIDQDAAEEAGVAIPLPGVKKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDARMLFDPFELDTSVTPARVRAALRQRDFTRAILMAFRLNERKLLQEALESVPWDEVEVVSSSLPDLYVEKVLEFLASSLEVSHHLEFYLVWAQKLLMAHGQKLKARAGTLLPAVQFLQKSIQRHFDGLSKLCDWNRYSLRFALAVSQQRGLKRASEAPGSEEEADGSDEDDESLHLLGAGPGDADGLRP", "length": 918 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QLU6-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "Pwp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKFAYRFSNLLGTVYRCGNLNFTQDGNSVISPVGNRVTVFDLKNNRSDTLPLATKYNIKCVGLSPDGRLAIIVDEGGEALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGALCVWQCDTPPEGLKLKPPKGWKADLLQREKEEEEEEEGEDEEEGDRETTIRGKTMPAEQEKAGKVKYSRLAKYFLNKEGDFNNLTAAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYILKQQGHFNSMVSLAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSILASASWDKTVRLWDMFDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQMGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQNILAGGMSKFVCLYHVREQILVKRFELSCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGVAVPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGRIREALRQREFTRAILMAFRLNEKKLAQEVLEAVPQDEIDVVSASLPELYVEKVLEFLAASFEVSRHLEFYLIWTQKLLMSHGQRLKPRAGQLLPVVQFLQKGLQRHLDDVSKLCDWNRYNIQYALAVSKQRGVKRTLEPVDTEEDTDASDDDSLHLLRGAADDEEEEEGMLV", "length": 925 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZV54-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "Pwp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKFAYRFSNLLGTVYRCGNLNFSRDGNSVISPVGNRVTVFDLKNNRSDTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVITKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKDAIVACFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWKADILQREKEEEEEEDEEGEGNRETTIRGKAVPAEQERVGKVKYSRLAKYFLNKEGDFNNLTAAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTATGHVIVTSSLDGTVRAYDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSILASASWDKTVRLWDMFDSWRTKETLSLTSDVLAVTYRPDGAELAVATLNSQITFWDPENAVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTVCYSADGQNILAGGMSKFVCLYHVREQILVKRFELSCNFSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGRIREALRQREFTRAILMAFRLNEKKLAQEALEAVPQNEIEVVSASLPELYVVKVLEFLAASFEESRHLEFYLIWTQKLLMSHGQRLKSRAGQLLPVVQFLQKGLQRHLDDISKLCDWNRYNIQYALAVSKQRGMKRTLEPVDTEEDTDASDEDSLHLLRAAEEEEEGMLV", "length": 920 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P25635-1", "protein_name": "Periodic tryptophan protein 2", "gene_name": "PWP2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKSDFKFSNLLGTVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLLIYSTNDTILFDPFDLDVDVTPHSTVEALREKQFLNALVMAFRLNEEYLINKVYEAIPIKEIPLVASNIPAIYLPRILKFIGDFAIESQHIEFNLIWIKALLSASGGYINEHKYLFSTAMRSIQRFIVRVAKEVVNTTTDNKYTYRFLVSTDGSMEDGAADDDEVLLKDDADEDNEENEENDVVMESDDEEGWIGFNGKDNKLPLSNENDSSDEEENEKELP", "length": 923 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q15269-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "PWP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQEDGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDTRVLFDPFELDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQKLKSRAGTLLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVSKQRGTKRSLDPLGSEEEAEASEDDSLHLLGGGGRDSEEEMLA", "length": 919 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54PE0-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "pwp2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKFGYKFSNLLGTVYNKGNILFTPDGNTVISPVGNRLTVFDLVNHTSITLPIQSKYNIRRLALSPNGQILITSDESGHTLIINLTRQVVLGEYKFFKTPKSILFSPNGAIIAIAVLEKVFLFKTPIIQKQPNPLIRLSVFTHKSAVISMCWSADSLKLMIGCKNGTLLIRQGKSERVSYFQVKGSGIINCFFGNEESTIAYAVTPTGLASWDYKTNEEMEQEKLERVENGETAYLREEEMDEEKLKVITENQRLYKGRWIFKGFKKFENYGVKCKVKTVCFHLKSKLLLVGFSTGQFILYEMPGFNQLYKLNISSHGISTSAINNTGEWLAFGCSELGQLLVWEWRSETYILKQQGHSYNMNTVAYSPDGQTIATGGEDGKVKIWNTTSGYCYITFTEHEGPVTAVKYSPVSSQNVVFSAGVDGTIRAFDLVRYRNFRTFVSPNKTQFSCLAVDPSGEIIAAGSLDSFEIYVWSVRTGRLTDILSGHQSPVCELAFDPINPFLASASWDKSCKIWNIFEDREIRESIQHTSDVLTCAYSQDGKKFIVSCLDGTIQIYETSTWGQIGLIDGKNDIMGGRGYKDEILAKNNSAGRAFTKIAFTPNGECIIAGGNSKYICIYHIDQQVLIKKYSTSSNLSLDGITLDINWKRVGEFGHLDAMEKDFDSDDDLYQQNKEYLTGSSKGDLSKRTTKKKQKTTSISVSPTGRAWAVSTTEGLLIYSLDDFLFFDPTDLSIDINPDSILSELNLKNYLKSLIMSIKLNEKPIIEKVFESIPFNEIQLVCQEFPIYYLKNFIQFLSGYFEKNHHLEFQMKWVKLISIYHGKYIKTNSLSMITSLRNLQKTITQTYNDISKVCDDNIFSMEYFKTVLLKELKSQEETNKISKKSQKYKKYLESKKNKEQEEDQFSDDEETVYQNNKKNKNK", "length": 922 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BU03-1", "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "Pwp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKFAYRFSNLLGTVYRCGNLNFTHDGNSVISPVGNRVTVFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKDAIVACFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWKADILQREKEEEEEDEEEGDRETTIRGKTTPAEQERVGKVKYSRLAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMFDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCLYHVREQILVKRFELSCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGVAVPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGRIREALRQREFTRAILMAFRLNEKKLAQEALEAVPQNEIEVVSTSLPELYVVKVLEFLAASFEESRHLEFYLIWTQKLLMSHGQRLKSRAGQLLPVVQFLQKGLQRHLDDVSKLCDWNRFNIQYVLAVSKQRGMKRTLEPVDTEEDSDASDEDSLHLLRAAGEEEEEEMLI", "length": 919 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VYZ5-1", "protein_name": "Periodic tryptophan protein 2", "gene_name": "PWP2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEFRFENLLGAPYRGGNAVITKNTQLISPVGNRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITFKDKVGALKFSPNGKFIAVGIGKLVEIWRSPGFRRAVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVRKLKGVLNKPFLFLGHRDSVVGCFFGVDKMTNKVNRAFTIARDGYIFSWGYTEKDVKMDESEDGHSEPPSPVTPDRADEVMVENGGGVGTELKKRKEYDGKGLESDEEGDDDDEEYMHRGKWVLLRKDGCNQASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKLGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTADPSGDVVCAGTLDSFEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDVFASKGTVETFRHNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAGGRVMTDRRSAANSSSGKCFTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQISHNLSLDGVLDFLHSKKMTEAGPIDLIDDDNSDEEGGIDKQSRGNLGYDLPGSRPNRGRPIIRTKSLSIAPTGRSFAAATTEGVLIFSIDDTFIFDPTDLDIDVTPEAVEAAIEEDEVSRALALSMRLNEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLLENCPHLEFILHWCQEICKAHGSSIQRNYRTLLPALRSLQKAITRAHQDLADMCSSNEYTLRYLCSVPNNH", "length": 900 }, "evidence": [ { "id": "E1BL00", "url": "https://omabrowser.org/oma/group/E1BL00/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "pmid": "" }, { "name": "Pwp2p-containing subcomplex of 90S preribosome", "id": "GO:0034388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034388", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "pmid": "" }, { "name": "ribosomal small subunit assembly", "id": "GO:0000028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000028", "evidence": [ { "database": "UniProtKB", "id": "E1BL00", "url": "https://www.uniprot.org/uniprotkb/E1BL00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 675, "end_pos": 677, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 948, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL00" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL00" }, { "id": "PF23381", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT122/SMU1 beta-propeller", "eco_id": "ECO_0000259", "start_pos": 360, "end_pos": 611, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL00" }, { "id": "PF04003", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Small-subunit processome Utp12", "eco_id": "ECO_0000259", "start_pos": 797, "end_pos": 901, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 675, "end_pos": 677 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q8MJ50-1", "uniprot_ac": "Q8MJ50", "uniprot_id": "OSTF1_BOVIN", "mass": { "chemical_mass": 23842.0, "monoisotopic_mass": 23842.0 }, "refseq": { "ac": "NP_776834", "name": "osteoclast-stimulating factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776834" }, "gene_names": [ { "name": "OSTF1", "type": "recommended", "evidence": [ { "id": "Q8MJ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ] }, { "name": "OSTF1", "type": "synonym", "evidence": [ { "id": "NP_776834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776834" } ] } ], "protein_names": [ { "name": "Osteoclast-stimulating factor 1", "type": "recommended", "evidence": [ { "id": "Q8MJ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50/entry#names_and_taxonomy" } ] }, { "name": "osteoclast-stimulating factor 1", "type": "synonym", "evidence": [ { "id": "NP_776834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776834" } ] } ], "function": [ { "annotation": "Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NJX5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJX5#function" }, { "database": "UniProtKB", "id": "ARBA00037432", "url": "https://www.uniprot.org/uniprotkb/ARBA00037432#function" }, { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50#function" }, { "database": "UniProtKB", "id": "A0AAA9RW27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW27#function" }, { "database": "UniProtKB", "id": "A0AAA9SC68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OSTF1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50", "locus": { "chromosome": "8", "start_pos": 51215173, "end_pos": 51153919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002746", "url": "https://www.ensembl.org/id/ENSBTAG00000002746" } ] } } ], "crossref": [ { "id": "Q8MJ50", "url": "https://alphafold.ebi.ac.uk/entry/Q8MJ50", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11772", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11772", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281961", "url": "https://www.ncbi.nlm.nih.gov/gene/281961", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281961", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281961", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NMSWLRE", "url": "https://omabrowser.org/oma/group/NMSWLRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJX5", "url": "https://www.orthodb.org/?gene=A0A3Q1NJX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8MJ50", "url": "https://www.orthodb.org/?gene=Q8MJ50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24155:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24155:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776834", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJX5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJ50-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHRDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLEKGARTDLRNNEKKLALDMATNAACASLLKKKQGTDAVRSLSNAEDYLDDEDSD", "length": 214, "header": "sp|Q8MJ50-1|OSTF1_BOVIN Isoform 1 of Osteoclast-stimulating factor 1 OS=Bos taurus OX=9913 GN=OSTF1 PE=2 SV=1 CANONICAL=Q8MJ50-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJX5-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50/entry#A0A3Q1NJX5-1", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHRDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLEKGARTDLRNNEKKLALDMATNAACASLLKKKQGTEFVVFCHTSTRISHRCSPIIKQC", "length": 218, "header": "tr|A0A3Q1NJX5-1|OSTF1_BOVIN Computationally mapped isoform of Osteoclast-stimulating factor 1 OS=Bos taurus OX=9913 GN=OSTF1 PE=2 SV=2 CANONICAL=Q8MJ50-1" }, "locus": { "chromosome": "8", "start_pos": 51214465, "end_pos": 51154056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079487.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079487.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072521.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072521.2" } ] } }, { "isoform_ac": "A0AAA9RW27-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50/entry#A0AAA9RW27-1", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHRDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLEKGARTDLRNNEKKLALDMATNAACASLLKKKQGTVIFLPSDLAFRCSPIIKQC", "length": 214, "header": "tr|A0AAA9RW27-1|A0AAA9RW27_BOVIN Computationally mapped isoform of Osteoclast-stimulating factor 1 OS=Bos taurus OX=9913 GN=OSTF1 PE=1 SV=1 CANONICAL=Q8MJ50-1" }, "locus": {} }, { "isoform_ac": "A0AAA9SC68-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50/entry#A0AAA9SC68-1", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHRDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLEKGARTDLRNNEKKLALDMATNAACASLLKKKQGTEFVVFCHTSTRISHSYLSTQ", "length": 215, "header": "tr|A0AAA9SC68-1|A0AAA9SC68_BOVIN Computationally mapped isoform of Osteoclast-stimulating factor 1 OS=Bos taurus OX=9913 GN=OSTF1 PE=1 SV=1 CANONICAL=Q8MJ50-1" }, "locus": { "chromosome": "8", "start_pos": 51214044, "end_pos": 51154056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096606.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096606.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081113.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081113.1" } ] } }, { "isoform_ac": "Q8MJ50-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50/entry#Q8MJ50-1", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHRDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLEKGARTDLRNNEKKLALDMATNAACASLLKKKQGTDAVRSLSNAEDYLDDEDSD", "length": 214, "header": "sp|Q8MJ50-1|OSTF1_BOVIN Isoform 1 of Osteoclast-stimulating factor 1 OS=Bos taurus OX=9913 GN=OSTF1 PE=2 SV=1 CANONICAL=Q8MJ50-1" }, "locus": { "chromosome": "8", "start_pos": 51214496, "end_pos": 51154056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102094.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102094.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077609.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077609.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "site_lbl": "Ser202" }, { "start_pos": 213, "end_pos": 213, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "site_lbl": "Ser213" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281961", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281961", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YS95-1", "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "OSTF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSKPPPKPAKPGQVKVFRALYTFEPRTPDELYFEEGDIIYISDMSDTNWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNQVGVNGLDKAGNTALYWACHGGHKDIVDVLFTQANLELNQQNKLGDTALHAAAWKGYADIVEMLLAKGARTDLKNNEKKLALDMATNAACASLLKKKQTAGTARTLSNAEEYLDDEDSD", "length": 214 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3ICW1-1", "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "Ostf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQATDGVRTLSNAEDYIDEEDSD", "length": 214 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54EQ2-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDDDQYFINQRLINAAKRGEEENVEEFVLDSENKVDINCTDSIGETSLHWAAKNNHAEVIKVLIRLKANVNAVQAGSLDTPLHKAAFKNNLDAIRILVVDGKANTNLKNKDDRTPLQLANDVECRKLLVPSVDTSVDDVVDEEDSDNE", "length": 148 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q62422-1", "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "Ostf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQQGTDGARTLSNAEDYLDDEDSD", "length": 215 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MJ49-1", "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "OSTF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVDMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD", "length": 214 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q92882-1", "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "OSTF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD", "length": 214 }, "evidence": [ { "id": "Q8MJ50", "url": "https://omabrowser.org/oma/group/Q8MJ50/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ50", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MJ50-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 214, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MJ50-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MJ50" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8MJ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ50" }, { "id": "PRU00192", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000255", "start_pos": 12, "end_pos": 71, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 202, 213 ], "sequon_annotation_sites": [ { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJH9-1", "uniprot_ac": "E1BJH9", "uniprot_id": "E1BJH9_BOVIN", "mass": { "chemical_mass": 124514.0, "monoisotopic_mass": 124514.0 }, "refseq": { "ac": "XP_059731793", "name": "axonemal dynein light chain domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731793" }, "gene_names": [ { "name": "AXDND1", "type": "recommended", "evidence": [ { "id": "E1BJH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH9" } ] }, { "name": "AXDND1", "type": "synonym", "evidence": [ { "id": "XP_059731793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731793" } ] } ], "protein_names": [ { "name": "Axonemal dynein light chain domain containing 1", "type": "synonym", "evidence": [ { "id": "E1BJH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH9/entry#names_and_taxonomy" } ] }, { "name": "axonemal dynein light chain domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731793" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJH9", "url": "https://www.uniprot.org/uniprotkb/E1BJH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AXDND1", "url": "https://www.uniprot.org/uniprotkb/E1BJH9", "locus": { "chromosome": "16", "start_pos": 60782457, "end_pos": 60703195, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002164", "url": "https://www.ensembl.org/id/ENSBTAG00000002164" } ] } } ], "crossref": [ { "id": "E1BJH9", "url": "https://alphafold.ebi.ac.uk/entry/E1BJH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613754", "url": "https://www.ncbi.nlm.nih.gov/gene/613754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613754", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LG29", "url": "https://www.orthodb.org/?gene=A0A3Q1LG29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BJH9", "url": "https://www.orthodb.org/?gene=E1BJH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23052:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23052:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10211", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10211", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731793", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731793", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LG29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LG29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJH9", "url": "https://www.uniprot.org/uniprotkb/E1BJH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJH9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLPKTPSTSTPEGKNLKISASKEETGLPELKEKKILVDRSQPLPTSLQNEFIPEEVLLSLTNAANAGPCPENLLPPKKIKTPKGTLPRSVDHVWHNPVRRNKFKYLIDHPVSLTGAGRDISFLYDVKYVKGETRESVVCPPQTDHALQARDGIIVPHKPKKLTDTLIPEEFHIVSNTGVSGLECFDDKYTTLLTDSENRLLLFPSMKPNKRIEVVQLNDVMDTMLERAGVENQEYTGPTKMHKLLHILKKEQTIYNTVFHELIRQVSVDCADRGELLSKIRERYVQMLDQIARQMIDFYKDMVTQRVMDQRILEELYNFKNVIEELTRELCLVRAHDIKLTKEAEKAHRDLAQALLDAEKNARIVEEYHDLYTLQRERMESDIKQLMAERDIWSSATYELSVKVIERNKVLLAKRLYLNEKSWNNYTKHFIVLLSSKDTSDLALLQKLTQKWKILVNKFQQEVERNEEATRERLQSVKDGLVKWQQFFRNNSEKDILSPHKQKTLESIVPDFKQWLTMLTEDRDKFSGDLLVSKYDSLKIIKRLQENWTDIGLGIFGRHKSMEGNIPPEQKLMEEILKNIARLYKEFEIRINGDNGTSKILPTLISSFEFCSFKLESLLEFPDLLLEEWEGLNEKINEVKSQLDSSLYIIGTVPQYIDMDSGLELQTHIFNMVQQWLLKIGGEINNGNMELQRQMDELHIPMIQWMVNLLILMIPDFPDPDILISLENSAEKRDLGIAKLELDAMALAKKLSQYSSYLSSCCKELVVAMAVNKASHLEKNPDKELNELEKMKVFVYVFLAVPGPCCCTHKPSLVVESRAATPCCAQASHCGGFPCCRAQKECYDWITTSSHLLSGLKGRKIKLLTHEEKQQLLGEEDILKGLSEPEAGKIHKEIEENMEDKKLEKEKKEESAEEKPSTSTEKEKIIRVIGEDENIHSQPLYGTDALSSWRESAHQGTLAPKYLEAMAILDRTQEKLIEVESRARQAEERFDDVNERLHYTLIRNKELEKELEEVLMKYKVKESEVEEEENEAEREEEKEEEEEIRPQDRSSKSPKKEIQRKEGSKSKLRTKSKTKPK", "length": 1078, "header": "tr|E1BJH9-1|E1BJH9_BOVIN Isoform 1 of Axonemal dynein light chain domain containing 1 OS=Bos taurus OX=9913 GN=AXDND1 PE=4 SV=4 CANONICAL=E1BJH9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LG29-1", "url": "https://www.uniprot.org/uniprotkb/E1BJH9/entry#A0A3Q1LG29-1", "sequence": { "sequence": "MSLPKTPSTSTPEGKNLKISASKEETGLPELKEKKILVDRSQPLPTSLQNEFIPEEVLLSLTNAANAGPCPENLLPPKKIKTPKGTLPRSVDHVWHNPVRRNKFKYLIDHPVSLTGAGRDISFLYDVKYVKGETRESVVCPPQTDHALQARDGIIVPHKPKKLTDTLIPEEFHIVSNTGVSGLECFDDKYTTLLTDSENRLLLFPSMKPNKRIEVVQLNDVMDTMLERAGVENQEYTGPTKMHKLLHILKKEQTIYNTVFHELIRQVSVDCADRGELLSKIRERYVQMLDQIARQMIDFYKDMVTQRVMDQRILEELYNFKNVIEELTRELCLVRAHDIKLTKEAEKAHRDLAQALLDAEKNARIVEEYHDLYTLQRERMESDIKQLMAERDIWSSATYELSVKVIERNKVLLAKRLYLNEKSWNNYTKHFIVLLSSKDTSDLALLQKLTQKWKILVNKFQQEVERNEEATRERLQSVKDGLVKWQQFFRNNSEKDILSPHKQKTLESIVPDFKQWLTMLTEDRDKFSGDLLVSKYDSLKIIKRLQENWTDIGLGIFGRHKSMEGNIPPEQKLMEEILKNIARLYKEFEIRINGDNGTSKILPTLISSFEFCSFKLESLLEFPDLLLEEWEGLNEKINEVKSQLDSSLYIIGTVPQYIDMDSGLELQTHIFNMVQQWLLKIGGEINNGNMELQRQMDELHIPMIQWMVNLLILMIPDFPDPDILISLENSAEKRDLGIAKLELDAMALAKKLSQYSSYLSSCCKELVVAMAVNKASHLEKNPDKELNELEKMKKECYDWITTSSHLLSGLKGRKIKLLTHEEKQQLLGEEDILKGLSEPEAGKIHKEIEENMEDKKLEKEKKEESAEEKPSTSTEKEKIIRVIGEDENIHSQPLYGTDALSSWRESAHQGTLAPKYLEAMAILDRTQEKLIEVESRARQAEERFDDVNERLHYTLIRNKELEKELEEVLMKYKVKESEVEEEENEAEREEEKEEEEEIRPQDRSSKSPKKEIQRKEGSKSKLRTKSKTKPK", "length": 1031, "header": "tr|A0A3Q1LG29-1|E1BJH9_BOVIN Computationally mapped isoform of Axonemal dynein light chain domain containing 1 OS=Bos taurus OX=9913 GN=AXDND1 PE=4 SV=2 CANONICAL=E1BJH9-1" }, "locus": { "chromosome": "16", "start_pos": 60781746, "end_pos": 60703731, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072064.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072064.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057289.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057289.2" } ] } }, { "isoform_ac": "E1BJH9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJH9/entry#E1BJH9-1", "sequence": { "sequence": "MSLPKTPSTSTPEGKNLKISASKEETGLPELKEKKILVDRSQPLPTSLQNEFIPEEVLLSLTNAANAGPCPENLLPPKKIKTPKGTLPRSVDHVWHNPVRRNKFKYLIDHPVSLTGAGRDISFLYDVKYVKGETRESVVCPPQTDHALQARDGIIVPHKPKKLTDTLIPEEFHIVSNTGVSGLECFDDKYTTLLTDSENRLLLFPSMKPNKRIEVVQLNDVMDTMLERAGVENQEYTGPTKMHKLLHILKKEQTIYNTVFHELIRQVSVDCADRGELLSKIRERYVQMLDQIARQMIDFYKDMVTQRVMDQRILEELYNFKNVIEELTRELCLVRAHDIKLTKEAEKAHRDLAQALLDAEKNARIVEEYHDLYTLQRERMESDIKQLMAERDIWSSATYELSVKVIERNKVLLAKRLYLNEKSWNNYTKHFIVLLSSKDTSDLALLQKLTQKWKILVNKFQQEVERNEEATRERLQSVKDGLVKWQQFFRNNSEKDILSPHKQKTLESIVPDFKQWLTMLTEDRDKFSGDLLVSKYDSLKIIKRLQENWTDIGLGIFGRHKSMEGNIPPEQKLMEEILKNIARLYKEFEIRINGDNGTSKILPTLISSFEFCSFKLESLLEFPDLLLEEWEGLNEKINEVKSQLDSSLYIIGTVPQYIDMDSGLELQTHIFNMVQQWLLKIGGEINNGNMELQRQMDELHIPMIQWMVNLLILMIPDFPDPDILISLENSAEKRDLGIAKLELDAMALAKKLSQYSSYLSSCCKELVVAMAVNKASHLEKNPDKELNELEKMKVFVYVFLAVPGPCCCTHKPSLVVESRAATPCCAQASHCGGFPCCRAQKECYDWITTSSHLLSGLKGRKIKLLTHEEKQQLLGEEDILKGLSEPEAGKIHKEIEENMEDKKLEKEKKEESAEEKPSTSTEKEKIIRVIGEDENIHSQPLYGTDALSSWRESAHQGTLAPKYLEAMAILDRTQEKLIEVESRARQAEERFDDVNERLHYTLIRNKELEKELEEVLMKYKVKESEVEEEENEAEREEEKEEEEEIRPQDRSSKSPKKEIQRKEGSKSKLRTKSKTKPK", "length": 1078, "header": "tr|E1BJH9-1|E1BJH9_BOVIN Isoform 1 of Axonemal dynein light chain domain containing 1 OS=Bos taurus OX=9913 GN=AXDND1 PE=4 SV=4 CANONICAL=E1BJH9-1" }, "locus": { "chromosome": "16", "start_pos": 60781746, "end_pos": 60703731, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044392.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044392.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041893.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041893.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613754", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613754", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJH9", "url": "https://www.uniprot.org/uniprotkb/E1BJH9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BJH9", "url": "https://www.uniprot.org/uniprotkb/E1BJH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "manchette assembly", "id": "GO:1905198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905198", "evidence": [ { "database": "UniProtKB", "id": "E1BJH9", "url": "https://www.uniprot.org/uniprotkb/E1BJH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 596, "end_pos": 598, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1078, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 426, "end_pos": 428 }, { "start_pos": 491, "end_pos": 493 }, { "start_pos": 548, "end_pos": 550 }, { "start_pos": 596, "end_pos": 598 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI51-1", "uniprot_ac": "E1BI51", "uniprot_id": "E1BI51_BOVIN", "mass": { "chemical_mass": 206321.0, "monoisotopic_mass": 206321.0 }, "refseq": { "ac": "XP_024852897", "name": "fibronectin type III domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852897" }, "gene_names": [ { "name": "FNDC1", "type": "recommended", "evidence": [ { "id": "E1BI51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ] }, { "name": "FNDC1", "type": "synonym", "evidence": [ { "id": "XP_024852897", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852897" } ] } ], "protein_names": [ { "name": "Fibronectin type III domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BI51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI51/entry#names_and_taxonomy" } ] }, { "name": "fibronectin type III domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852897", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852897" } ] } ], "function": [ { "annotation": "May be an activator of G protein signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LG82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG82#function" }, { "database": "UniProtKB", "id": "ARBA00059566", "url": "https://www.uniprot.org/uniprotkb/ARBA00059566#function" }, { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FNDC1", "url": "https://www.uniprot.org/uniprotkb/E1BI51", "locus": { "chromosome": "9", "start_pos": 95591576, "end_pos": 95479849, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003938", "url": "https://www.ensembl.org/id/ENSBTAG00000003938" } ] } } ], "crossref": [ { "id": "ENSBTAG00000003938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100850256", "url": "https://www.ncbi.nlm.nih.gov/gene/100850256", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100850256", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100850256", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QIGFGTP", "url": "https://omabrowser.org/oma/group/QIGFGTP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LG82", "url": "https://www.orthodb.org/?gene=A0A3Q1LG82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BI51", "url": "https://www.orthodb.org/?gene=E1BI51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23197:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23197:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21731", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21731", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024852897", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852897", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LG82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LG82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI51-1", "url": "https://www.uniprot.org/uniprotkb/E1BI51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPEVRASHRARRPLPWAALLLLAALLPVVSPAGAAPADHPLKPRHVKLLSTKMGLKVTWDPPKDATNRSVEHYNIAYGKSLKSLKYIKVNAETHSFLIEDVEPGVVYFVLVTAENSNGVSRPVYRAESLPGGEWIKIDGFPIKGPGPFNETVTEKDVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSRGQSQPVYRAALTKRKISEEDELDVPEDINVRVMSSQSVLVAWVDPVLEKQKKVVASRQYTVRYREKGESARWDYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWPVNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGERYLFKIRAANRRGMGPHSKAFIVALPPTPTSESEVQQKTDREDQHKPEKPEPSSSPKAPAPSKHTHLPVSPQGRNVKSPILDFKNKILANGGLLRKAQLPPRKNGGLGLQSTEITDEEEPDSRGDPPTSPPETQGQKSQQRPPSRPVHPFLAAGRTPVRARTPMLPRKEGVDQRGSSPTSHPRPGAPPSASASFSASRPPPESSTHRLSGGPSTSRPSSSTDNDSVGLEEEETTARSPPPKDALSEHLPGKSAAHAQPALSSGRHPAWSALRDRSAAHHGTRPALPARRAPHSEDREEGSRASAPPSRLSPSPGGSSRLLITEPQPGSPLSRGWKDGQDAPAARSNAPSGSTRPSSRTQASEGAGGSDGDGESDTEERGRPAAATAPTFRSRLPAGPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSSPPSTASPRVHLRVDSHPASDHRRGPGGQEDSEEEAEDEKPLPATVVNHHVSSSSRQPASRGADHLRRGPQRGASLQRKEPLPENPKSTGTWAGVPPQAKPPSSKAQDTQQSTDAGAEGGSPKTQLGGRPPAPRSPHHQEPTGPQRMGAGSAALQKSPSVAVPASQPQPHGPRSKEVGRPPSRPQPAFPSEAGRPHPTSQESASFSDSYSSRGGQSSRAASPQNLDDDSAEAGTGGVRAPAYSAGAKDATPSLPKHRQVDAQAGSAGDGHLRRPAGRPGSLHPHARTRVPGRVGPQWAGRKDGASQASPAKREPLPSKSQQSVSAEEENEDVMFFKGGKDKDPQSSSAPKWPSSFSPRGGKHVDRTLAKGETEPVIVLAPPRVGSPHDENATPVKRPLSPPAGSSPRASHLPPRQPARSPAATPSPTVGTPAPPRFTTRAPAPSAPTTPMLSLRQRMMNSRFRNPFSRAPVRPPSRPGYNGRPNGEGRVLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKLGGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLEVIKTTTRAPITTTRPTTTTPRPTTTPRPTTSPRPTTTTTRPTTTRTTTRRTTTTTPEPTTPIPTCPPGTLERHDKDGNLIMGSRGVPECYPEEDEFSGLETDTAVPTEEAYVIYDEDYEVETSGPPPTTQSSTTTTTTTTTTTPAVIPPEGSISSYPEEEFDLAGKKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKAAPGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGFGTPYYYVGWYECGVSIPGKW", "length": 1909, "header": "tr|E1BI51-1|E1BI51_BOVIN Isoform 1 of Fibronectin type III domain-containing protein 1 OS=Bos taurus OX=9913 GN=FNDC1 PE=4 SV=3 CANONICAL=E1BI51-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LG82-1", "url": "https://www.uniprot.org/uniprotkb/E1BI51/entry#A0A3Q1LG82-1", "sequence": { "sequence": "MAPEVRASHRARRPLPWAALLLLAALLPVVSPAGAAPEKDVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSRGQSQPVYRAALTKRKISEEDELDVPEDINVRVMSSQSVLVAWVDPVLEKQKKVVASRQYTVRYREKGESARWDYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWPVNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGERYLFKIRAANRRGMGPHSKAFIVALPPTPTSESEVQQKTDREDQHKPEKPEPSSSPKAPAPSKHTHLPVSPQGRNVKSPILDFKNKILANGGLLRKAQLPPRKNGGLGLQSTEITDEEEPDSRGDPPTSPPETQGQKSQQRPPSRPVHPFLAAGRTPVRARTPMLPRKEGVDQRGSSPTSHPRPGAPPSASASFSASRPPPESSTHRLSGGPSTSRPSSSTDNDSVGLEEEETTARSPPPKDALSEHLPGKSAAHAQPALSSGRHPAWSALRDRSAAHHGTRPALPARRAPHSEDREEGSRASAPPSRLSPSPGGSSRLLITEPQPGSPLSRGWKDGQDAPAARSNAPSGSTRPSSRTQASEGAGGSDGDGESDTEERGRPAAATAPTFRSRLPAGPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSSPPSTASPRVHLRVDSHPASDHRRGPGGQEDSEEEAEDEKPLPATVVNHHVSSSSRQPASRGADHLRRGPQRGASLQRKEPLPENPKSTGTWAGVPPQAKPPSSKAQDTQQSTDAGAEGGSPKTQLGGRPPAPRSPHHQEPTGPQRMGAGSAALQKSPSVAVPASQPQPHGPRSKEVGRPPSRPQPAFPSEAGRPHPTSQESASFSDSYSSRGGQSSRAASPQNLDDDSAEAGTGGVRAPAYSAGAKDATPSLPKHRQVDAQAGSAGDGHLRRPAGRPGSLHPHARTRVPGRVGPQWAGRKDGASQASPAKREPLPSKSQQSVSAEEENEDVMFFKGGKDKDPQSSSAPKWPSSFSPRGGKHVDRTLAKGETEPVIVLAPPRVGSPHDENATPVKRPLSPPAGSSPRASHLPPRQPARSPAATPSPTVGTPAPPRFTTRAPAPSAPTTPMLSLRQRMMNSRFRNPFSRAPVRPPSRPGYNGRPNGEGRVLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKLGGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLEVIKTTTRAPITTTRPTTTTPRPTTTPRPTTSPRPTTTTTRPTTTRTTTRRTTTTTPEPTTPIPTCPPGTLERHDKDGNLIMGSRGVPECYPEEDEFSGLETDTAVPTEEAYVIYDEDYEVETSGPPPTTQSSTTTTTTTTTTTPAVIPPEGSISSYPEEEFDLAGKKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKAAPGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGFGTPYYYVGWYECGVSIPGKW", "length": 1792, "header": "tr|A0A3Q1LG82-1|E1BI51_BOVIN Computationally mapped isoform of Fibronectin type III domain-containing protein 1 OS=Bos taurus OX=9913 GN=FNDC1 PE=4 SV=1 CANONICAL=E1BI51-1" }, "locus": { "chromosome": "9", "start_pos": 95590686, "end_pos": 95480045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083694.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083694.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057390.1" } ] } }, { "isoform_ac": "E1BI51-1", "url": "https://www.uniprot.org/uniprotkb/E1BI51/entry#E1BI51-1", "sequence": { "sequence": "MAPEVRASHRARRPLPWAALLLLAALLPVVSPAGAAPADHPLKPRHVKLLSTKMGLKVTWDPPKDATNRSVEHYNIAYGKSLKSLKYIKVNAETHSFLIEDVEPGVVYFVLVTAENSNGVSRPVYRAESLPGGEWIKIDGFPIKGPGPFNETVTEKDVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSRGQSQPVYRAALTKRKISEEDELDVPEDINVRVMSSQSVLVAWVDPVLEKQKKVVASRQYTVRYREKGESARWDYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWPVNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGERYLFKIRAANRRGMGPHSKAFIVALPPTPTSESEVQQKTDREDQHKPEKPEPSSSPKAPAPSKHTHLPVSPQGRNVKSPILDFKNKILANGGLLRKAQLPPRKNGGLGLQSTEITDEEEPDSRGDPPTSPPETQGQKSQQRPPSRPVHPFLAAGRTPVRARTPMLPRKEGVDQRGSSPTSHPRPGAPPSASASFSASRPPPESSTHRLSGGPSTSRPSSSTDNDSVGLEEEETTARSPPPKDALSEHLPGKSAAHAQPALSSGRHPAWSALRDRSAAHHGTRPALPARRAPHSEDREEGSRASAPPSRLSPSPGGSSRLLITEPQPGSPLSRGWKDGQDAPAARSNAPSGSTRPSSRTQASEGAGGSDGDGESDTEERGRPAAATAPTFRSRLPAGPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSSPPSTASPRVHLRVDSHPASDHRRGPGGQEDSEEEAEDEKPLPATVVNHHVSSSSRQPASRGADHLRRGPQRGASLQRKEPLPENPKSTGTWAGVPPQAKPPSSKAQDTQQSTDAGAEGGSPKTQLGGRPPAPRSPHHQEPTGPQRMGAGSAALQKSPSVAVPASQPQPHGPRSKEVGRPPSRPQPAFPSEAGRPHPTSQESASFSDSYSSRGGQSSRAASPQNLDDDSAEAGTGGVRAPAYSAGAKDATPSLPKHRQVDAQAGSAGDGHLRRPAGRPGSLHPHARTRVPGRVGPQWAGRKDGASQASPAKREPLPSKSQQSVSAEEENEDVMFFKGGKDKDPQSSSAPKWPSSFSPRGGKHVDRTLAKGETEPVIVLAPPRVGSPHDENATPVKRPLSPPAGSSPRASHLPPRQPARSPAATPSPTVGTPAPPRFTTRAPAPSAPTTPMLSLRQRMMNSRFRNPFSRAPVRPPSRPGYNGRPNGEGRVLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKLGGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLEVIKTTTRAPITTTRPTTTTPRPTTTPRPTTSPRPTTTTTRPTTTRTTTRRTTTTTPEPTTPIPTCPPGTLERHDKDGNLIMGSRGVPECYPEEDEFSGLETDTAVPTEEAYVIYDEDYEVETSGPPPTTQSSTTTTTTTTTTTPAVIPPEGSISSYPEEEFDLAGKKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKAAPGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGFGTPYYYVGWYECGVSIPGKW", "length": 1909, "header": "tr|E1BI51-1|E1BI51_BOVIN Isoform 1 of Fibronectin type III domain-containing protein 1 OS=Bos taurus OX=9913 GN=FNDC1 PE=4 SV=3 CANONICAL=E1BI51-1" }, "locus": { "chromosome": "9", "start_pos": 95590686, "end_pos": 95480045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039897.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039897.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039682.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039682.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1113, "start_aa": "Thr", "end_pos": 1113, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1113", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1286, "start_aa": "Thr", "end_pos": 1286, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1286", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1290, "start_aa": "Thr", "end_pos": 1290, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1290", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 380, "start_aa": "Thr", "end_pos": 380, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr380", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 458, "start_aa": "Thr", "end_pos": 458, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr458", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100850256", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100850256", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A6I8MWX0-1", "protein_name": "Fibronectin type III domain-containing protein 1", "gene_name": "Fndc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPEARASPRLLLRAALLLLAALLPVATSAGPPVDHPLKPRHVKLLSTNMGLKVTWDPPKDASSRPVEYYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHSGVSRPVYRAESPPGGEWIKIDGFPIKGPGPFNETVTEKEVPNKPLRMRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTNSQGQSQPVYRAALTKRKHAEEDELDVPEDISVRVMSSQSVLVAWVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGPGPHSKAFIVAIPTTSSTEASAQPNGRDSSRKPEKLQQPSSPAPKVAASSEHTPSAKNVKDALSDLNKIRTNSVVPGKTQLHSKMGELDPQSTEVTGEEELDSLEDPRSSRLETLNQKQPLRVPSRSGHGVLTPGRTPARTGLPVLPRKEVMDRRGPSLDPHLRPRVEPSASSAYHQLSSIDNDSVDQNEYDQAGSPDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAQPRSHSLLQGGSSRPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEEDTSDGGADIDRAAGDTRRRAEATAQIQQTRPALGHFSLIRNKPFPAHSRNPSRFPKLRGPRLQPSRSPQSTSASKVLTRAPSLPASHTRPGSDVYGDGEDEEPLPATVVNDRTPSSSSHPISGGSDTLRRGSQRGASLYRKEPIPENSKAAGADVHPGGKSPLSSKAQGFQLSTDEGAPQTPPSSTSRQLSPARHPASRSQPSPGSTVPRRMAPGRSSELSSSQSKDRSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQNEGSQSSYEDNSTEIEGPDPRAPTHSAHAKDTTPSILKPQQMGSQSGNSGNRPQPSRSGASERPIRPGSTHPRVQVPGRAGLQATPAKKISSSKHPLPPESQQSVFTEEEEENEGILKGKEDSLSTSVKKWPSSSSPRNNKYADRNLDRDKAAIGQLVQEEDSIPGRRSPGSPPIASHPPTWYQPRNPVTASPSASTHSWPRYTTRAPSTYSSTTPMLSLRQRMQRRFRTPVSRQPPPRPVLTSGYNGRANVGENIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRLGGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLEVIKTTTYSPTTTMLPTTTTTTVLTTTTRPPTTTTTTTRRTTTRRTTTTRHPTTTIRATRRTTTTTTTPEPTTPSPTCPPGTLEHQDEAGNLIMGSNGIPECYPEEDDFSGLETDTAPPTEEDYVVYDDDYGFETTRPPTSTMPSTTAATPKVIPEQGTVSSFPEEEFDLAGKRRFVAPYVTYLSKDPTAPCSLTDALDHFQVESLDELIPNDLTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGHIGFGTPYYYVGWYECGVSIPGKW", "length": 1833 }, "evidence": [ { "id": "E1BI51", "url": "https://omabrowser.org/oma/group/E1BI51/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q2Q0I9-1", "protein_name": "Fibronectin type III domain-containing protein 1", "gene_name": "Fndc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPEARASPRLLLRAALLLLAALLPVASSAGPPVDHPLKPRHVKLLSANMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKSIKVNAETHSFLIKDVEKEVPNKPLRMRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTNSQGQSQPVYRAALTKRKNAEEDELDVPEDISVRVMSSQSVLVAWVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRALVDSLIPDTVYEFAVRISQGERDGKWSASVFQRTPESAPTTAPENLRVWPVNGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGQGPHSKAFIVAIPTTSSTEASVQPNGRDNGKPEKPQQPSSSAPKVAASSQHMPPAKNVKDALSDLKNKIQTNGVAPGRTQLHSKVGELDPQSTEVTGEEELDSLENPRSSRLETLNQKQPLRVPSRSGHGALAPGRTPARAGLPVLSRKEGMDRRGPSLDPHPHPRVEPSASSAYHQLSSTDNDSVDRKEDDQAGSPDPKAASSGSSPKNPGRSRPTSAPSRHAASNMLRDKSRVHPGTKAASSSTSRQSHSSTSEEDSSAQPSRHFPLHRGSSTSPLSRGWKDRQDTHASSSHTTSRTASSSHPSALTEGSEEEDGGADSDRAAEDTIRRAEATAQIQQTRPGLGHFSLIRNKPFTPHSRNPNRFPRLRGPRLQPSVSPQSTSASKVLTRSPSLPASHTRPGSDVYGDGEDEEPLPATVINDRTPSYPRHPISGSSDTLRRGPQRGASLYRKEPIPENSKAAGADVPPGGRSPLSSKAQGFQQSTTDEGAPQTSPASTSRQPSPARPPASRSQPSPGSTVPRRMTPDRSSELSSSQSKDRSLSQPKLSVAHAGHDHPHTANSRGVLPSAPQNQNEGAQSTYEDNSTEIEGPDSRTPTHSARAKDTTPPILKPRQVGSQSWSSDNRPQPSQAGASERPIRPGSTHPRAQVPGRAGVQATSVKKVSPSKRPLPLESQQSVFAEEEEENEGMLKGKEDSLSTSVKKWPSSSSPRDKYADRNLDKDKAAIGLLVQEENTVPGRRPPGSPAIASHPSTRHQPRNPATASPIANTHSWPRYTTRAPSSYSSTTPMLSLRQRMQRRFRTPVSRQPPPPRPVLTPGYNGRPNAEENIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRLGGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLEVVRTTTQVPTTTMPPSTTTTTVPPTTTLPPTTTTTRRTTTTRRTTTTRRPTTTTRATRRTTTTTTTPEPTTPSPTCPPGTLEHRDEAGNLIMGSNGIPECYPEEDDFSGLEIDTALPTEEDYVVYDDDYGLETTRPPTSTMPSTTAATPKVVPEQGTVSSFPEEEFDLAGKRRFVAPYVTYLSKDPAAPCSLTDALDHFQVESLDELIPNDLTKNDLPPQHAPRNITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGHIGFGTPYYYVGWYECGVSIPGKW", "length": 1779 }, "evidence": [ { "id": "E1BI51", "url": "https://omabrowser.org/oma/group/E1BI51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4ZHG4-1", "protein_name": "Fibronectin type III domain-containing protein 1", "gene_name": "FNDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW", "length": 1894 }, "evidence": [ { "id": "E1BI51", "url": "https://omabrowser.org/oma/group/E1BI51/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BI51", "url": "https://www.uniprot.org/uniprotkb/E1BI51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1676, "end_pos": 1678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI51" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 132, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 380, 458, 1113, 1286, 1290 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1253, "end_pos": 1255 }, { "start_pos": 150, "end_pos": 152 }, { "start_pos": 1676, "end_pos": 1678 }, { "start_pos": 325, "end_pos": 327 }, { "start_pos": 653, "end_pos": 655 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK42-1", "uniprot_ac": "E1BK42", "uniprot_id": "E1BK42_BOVIN", "mass": { "chemical_mass": 130808.0, "monoisotopic_mass": 130808.0 }, "refseq": {}, "gene_names": [ { "name": "PLEKHA6", "type": "recommended", "evidence": [ { "id": "E1BK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK42" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain containing A6", "type": "synonym", "evidence": [ { "id": "E1BK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK42", "url": "https://www.uniprot.org/uniprotkb/E1BK42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHA6", "url": "https://www.uniprot.org/uniprotkb/E1BK42", "locus": { "chromosome": "16", "start_pos": 1989126, "end_pos": 2125401, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004641", "url": "https://www.ensembl.org/id/ENSBTAG00000004641" } ] } } ], "crossref": [ { "id": "E1BK42", "url": "https://alphafold.ebi.ac.uk/entry/E1BK42", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004641", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004641", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LHM4", "url": "https://www.orthodb.org/?gene=A0A3Q1LHM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKH4", "url": "https://www.orthodb.org/?gene=A0A3Q1LKH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M501", "url": "https://www.orthodb.org/?gene=A0A3Q1M501", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI21", "url": "https://www.orthodb.org/?gene=A0A3Q1MI21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MP94", "url": "https://www.orthodb.org/?gene=A0A3Q1MP94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BK42", "url": "https://www.orthodb.org/?gene=E1BK42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LHM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKH4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M501", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M501", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M501-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M501-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP94", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP94-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK42", "url": "https://www.uniprot.org/uniprotkb/E1BK42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK42-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNCPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESEALISVVNRMVESSSPSAQLFMQVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEEPGPPRPPLPKAYVPLESPPTVPPLPSESRFWPHPNSPSWHRGGETARGQPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLPSEPPRGADSSHVMRV", "length": 1173, "header": "tr|E1BK42-1|E1BK42_BOVIN Isoform 1 of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=3 CANONICAL=E1BK42-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#A0A3Q1LHM4-1", "sequence": { "sequence": "MADEIDWLDLPGRWTYGVDRGGRVFFINDEEKSTCWVHPGTASPIQSGHSSCPGLPKGWEMDSTQEGAVYFINHNERRNTFLHPLTGQVPEENKKFDLKISALDMSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKVTVCWVDEAGASSTHCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRQERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQALAEANAAKLQRATF", "length": 1153, "header": "tr|A0A3Q1LHM4-1|E1BK42_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=2 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2125202, "end_pos": 1990130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083332.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083332.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058272.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058272.2" } ] } }, { "isoform_ac": "A0A3Q1LKH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#A0A3Q1LKH4-1", "sequence": { "sequence": "MADEIDWLDLPGRWTYGVDRGGRVFFINDEEKSTCWVHPGTASPIQSGHSSCPGLPKGWEMDSTQEGAVYFINHNERRNTFLHPLTGQVPEENKKFDLKISALDMSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKVTVCWVDEAGASSTHCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKMSESEALISVVNRMVESSSPSAQLFMQVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRQERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQALAEANAAKLQRATF", "length": 1180, "header": "tr|A0A3Q1LKH4-1|E1BK42_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=2 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2125202, "end_pos": 1990130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086923.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086923.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057157.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057157.2" } ] } }, { "isoform_ac": "A0A3Q1M501-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#A0A3Q1M501-1", "sequence": { "sequence": "MADEIDWLDLPGRWTYGVDRGGRVFFINDEEKSTCWVHPGTASPIQSGHSSCPGLPKGWEMDSTQEGAVYFINHNERRNTFLHPLTGQVPEENKKFDLKISALDMSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNCPPSPTVHDKMDELLDLQLQRNLEYLDQQVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRQERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLPSEPPRGADSSHVMRV", "length": 1201, "header": "tr|A0A3Q1M501-1|A0A3Q1M501_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=2 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2125202, "end_pos": 1990804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067542.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067542.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065326.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065326.2" } ] } }, { "isoform_ac": "A0A3Q1MI21-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#A0A3Q1MI21-1", "sequence": { "sequence": "MADEIDWLDLPGRWTYGVDRGGRVFFINDEEKSTCWVHPGTASPIQSGHSSCPGLPKGWEMDSTQEGAVYFINHNERRNTFLHPLTGQVPEENKKFDLKISALDMSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKVTVCWVDEAGASSTHCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNCPPSPTVHDKMVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRQERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQALAEANAAKLQRATF", "length": 1182, "header": "tr|A0A3Q1MI21-1|A0A3Q1MI21_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=2 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2125202, "end_pos": 1990130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072035.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072035.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073928.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073928.2" } ] } }, { "isoform_ac": "A0A3Q1MP94-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#A0A3Q1MP94-1", "sequence": { "sequence": "MSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKVTVCWVDEAGASSTHCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNCPPSPTVHDKMVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRQERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQALAEANAAKLQRATF", "length": 1078, "header": "tr|A0A3Q1MP94-1|A0A3Q1MP94_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=2 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2029945, "end_pos": 1990130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080546.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080546.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073231.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073231.2" } ] } }, { "isoform_ac": "E1BK42-1", "url": "https://www.uniprot.org/uniprotkb/E1BK42/entry#E1BK42-1", "sequence": { "sequence": "MSNKAGGKRSAATDRDLTNHSMVSEVPPERPGVRAARPSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESVLGSVPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSAPPQASRHNHEKPDSENIPPGKHHHQLPHNSVPKPEPEAKTRGEGDGRGCEKAERRPERPDAKSEPLVKSNGVHAGPEPASEPGSPFPEGLRVPGGGERPAQPNGWQYSSPSRPGSTAFPPQDSESGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGIPPPEDLRSPSRFYPVSRRVPEYYSPYSSQFPDDYQYYPPGVRPDSICSMPAYDRVSPPWALEDKRHSFRNGGGPAFQLREWKEPAGLGRPDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPGQGSYSRSRVYSPARSPRAHFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNCPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESEALISVVNRMVESSSPSAQLFMQVPPYPEVFQDSLHTYKLNEQDTDKLLGKLCEQNKAVREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALANSTMEYESLEAEVSALHDELWEQLSLDLQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSGTYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGFSEEPGPPRPPLPKAYVPLESPPTVPPLPSESRFWPHPNSPSWHRGGETARGQPKASYEQSKRDPQQTSPLDTSRDISLVSTRQEVEAEKQAALNKVGIVPPRTKSPTDEEVTPSRVVRRSANGLTNGLSSRERPKSAVFPCEGKAKMSVEEQMDRMRRRQSGSARDKRRSLQLPPSPAPDPGARPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDMPLSPEELKEKQKKVERIKTLIAKSSMQNVVPVGEGDFVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLPSEPPRGADSSHVMRV", "length": 1173, "header": "tr|E1BK42-1|E1BK42_BOVIN Isoform 1 of Pleckstrin homology domain containing A6 OS=Bos taurus OX=9913 GN=PLEKHA6 PE=4 SV=3 CANONICAL=E1BK42-1" }, "locus": { "chromosome": "16", "start_pos": 2029945, "end_pos": 1990804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061459.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061459.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053803.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053803.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1140, "start_aa": "Thr", "end_pos": 1140, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1140", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1140 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 687, "end_pos": 689 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF59-1", "uniprot_ac": "E1BF59", "uniprot_id": "E1BF59_BOVIN", "mass": { "chemical_mass": 531039.0, "monoisotopic_mass": 531039.0 }, "refseq": { "ac": "XP_024857674", "name": "plectin isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857674" }, "gene_names": [ { "name": "PLEC", "type": "recommended", "evidence": [ { "id": "E1BF59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ] }, { "name": "PLEC", "type": "synonym", "evidence": [ { "id": "XP_024857674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857674" } ] } ], "protein_names": [ { "name": "Plectin", "type": "recommended", "evidence": [ { "id": "E1BF59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#names_and_taxonomy" } ] }, { "name": "Plectin-1", "type": "synonym", "evidence": [ { "id": "E1BF59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#names_and_taxonomy" } ] }, { "name": "plectin isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024857674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857674" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEC", "url": "https://www.uniprot.org/uniprotkb/E1BF59", "locus": { "chromosome": "14", "start_pos": 896535, "end_pos": 839954, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011922", "url": "https://www.ensembl.org/id/ENSBTAG00000011922" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00176", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00176", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21188", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21188", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21238", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21238", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786966", "url": "https://www.ncbi.nlm.nih.gov/gene/786966", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EERWVYR", "url": "https://omabrowser.org/oma/group/EERWVYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-264870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-446107", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446107", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024857674", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857674", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJL6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJL6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVA4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVA4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXK9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXK9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2E4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2E4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6Q7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6Q7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6Q7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQG2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQG2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIP5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIP5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF59-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAGMFMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWRHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGCPPKRGPPPTEDPAREERCVYRRKEPEEGAPEPPVVPAATPGTLARQGLEPAPPTDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4671, "header": "tr|E1BF59-1|E1BF59_BOVIN Isoform 1 of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=3 CANONICAL=E1BF59-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJL6-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1LJL6-1", "sequence": { "sequence": "MEPSGSLFPSLVVVGHVVTLAAVWHWRRGRPRVQDEQDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGKCGQCGGWWDARGGPPAVGRRANWMCSPGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4558, "header": "tr|A0A3Q1LJL6-1|E1BF59_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=1 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 868798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078025.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078025.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059639.1" } ] } }, { "isoform_ac": "A0A3Q1LVA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1LVA4-1", "sequence": { "sequence": "MSGEDQEVRAVVEDGSNGGSGSPSPGDTLPWNLEKTQRSRRGGGGPGGNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRERDVIRSSRLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGKCGQCGGWWDARGGPPAVGRRANWMCSPGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4597, "header": "tr|A0A3Q1LVA4-1|A0A3Q1LVA4_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=1 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 841384, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075231.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075231.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064542.1" } ] } }, { "isoform_ac": "A0A3Q1LXH1-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1LXH1-1", "sequence": { "sequence": "MVAGMFMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWRHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGCPPKRGPPPTEDPAREERCVYRRKEPEEGAPEPPVVPAATPGTLARQGLEPAPPTDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGKCGQCGGWWDARGGPPAVGRRANWMCSPGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4700, "header": "tr|A0A3Q1LXH1-1|A0A3Q1LXH1_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=1 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 862943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087039.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087039.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065466.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065466.1" } ] } }, { "isoform_ac": "A0A3Q1LXK9-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1LXK9-1", "sequence": { "sequence": "MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4497, "header": "tr|A0A3Q1LXK9-1|A0A3Q1LXK9_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=2 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 868129, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086342.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086342.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061946.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061946.2" } ] } }, { "isoform_ac": "A0A3Q1M2E4-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1M2E4-1", "sequence": { "sequence": "MSKGAGLMAAPGIRGAGVSFAAQKEVVLERPCWLDGGCEQARRGYLYRQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4545, "header": "tr|A0A3Q1M2E4-1|A0A3Q1M2E4_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=2 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 868901, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078854.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078854.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063950.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063950.2" } ] } }, { "isoform_ac": "A0A3Q1M6Q7-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1M6Q7-1", "sequence": { "sequence": "MSGEDQEVRAVVEDGSNGGSGSPSPGDTLPWNLEKTQRSRRGGGGPGGNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRERDVIRSSRLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4573, "header": "tr|A0A3Q1M6Q7-1|A0A3Q1M6Q7_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=2 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 841384, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076728.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076728.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065695.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065695.2" } ] } }, { "isoform_ac": "A0A3Q1MQG2-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1MQG2-1", "sequence": { "sequence": "MAAPGIRGAGVSFAAQKEVVLERPCWLDGGCEQARRGYLYRQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4538, "header": "tr|A0A3Q1MQG2-1|A0A3Q1MQG2_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=3 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 870282, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076063.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076063.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074252.3", "url": "https://www.ensembl.org/id/ENSBTAP00000074252.3" } ] } }, { "isoform_ac": "A0A3Q1MRS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1MRS3-1", "sequence": { "sequence": "MVAGMFMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWRHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGCPPKRGPPPTEDPAREERCVYRRKEPEEGAPEPPVVPAATPGTLARQGLEPAPPTDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRERDVIRSSRLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGKCGQCGGWWDARGGPPAVGRRANWMCSPGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4712, "header": "tr|A0A3Q1MRS3-1|A0A3Q1MRS3_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=1 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 862943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082561.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082561.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074548.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074548.1" } ] } }, { "isoform_ac": "A0A3Q1NIP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#A0A3Q1NIP5-1", "sequence": { "sequence": "MSQQRLRVPEPEGLGHKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGKCGQCGGWWDARGGPPAVGRRANWMCSPGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4558, "header": "tr|A0A3Q1NIP5-1|A0A3Q1NIP5_BOVIN Computationally mapped isoform of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=1 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 872935, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083372.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083372.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071923.1" } ] } }, { "isoform_ac": "E1BF59-1", "url": "https://www.uniprot.org/uniprotkb/E1BF59/entry#E1BF59-1", "sequence": { "sequence": "MVAGMFMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWRHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGCPPKRGPPPTEDPAREERCVYRRKEPEEGAPEPPVVPAATPGTLARQGLEPAPPTDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVKANELQLRWQEYRELVLLLLQWIRAHTAAFEERRFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLERLQRIVSKLQMEAGLCEEQLNQADALLQSDVRLLAAGKAPQRAGEVERDLDKADGMIRLLFNDVQALKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLRGTPRHPELEDSTLRYLQDLLAWVEENQRRLDGAEWGVDLPSVEAQLGSHRGLHQSVEEFRAKIERARTDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLSEKEEEEVGFDWSERNSNMAAKKEAYSALMRELELKEKKIKEIQSTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLRKLQETLHRKYTCDRSITVTRLEDLLQDAQDEKDQLNEYRGHLSGLAKRAKAIVQLTPRNPTQPTRGRVPLLAVCDYKQVEATVHKGDECQMLGPAQPFHWKVLSGSGSEAAVPSVCFLVPPPNQEALEAVARLEAQHQALVTLWHQLHTDMKSLLAWQSLSRDVQLIRSWSLVTFRTLKPEEQRQALRSLELHYQAFLRDSQDAGGFGPEDRLQAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEALKAHEEQLKEAQAVPAALPELEATKAAMKKLRAQAEAQQPVFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAVPLADSQAVREQLRQEKALLEEIERHAEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELSTLTSQYIRFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAQELQRRMQEEVARREEVVVDAQQQKRSIQEELQQLRQSSEAEIQAKARQVEAAERSRLRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDETQRKRQAEAELGLRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEAERARQVQVALETAQRSAQAELQSKHASFAEKTAQLERTLEEEHVTVVQLREEATRREQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEAAEREARRRGKAEEQAVRQRELAEQELERQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQSEAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSSSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLSEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRGNAEDTLRSKEQAEQEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSMLERLRGEAEAARRAAEEAEEARERAEGEAAQSRQRVEEAERLKQAAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTALRLKLEETDHQKSILDQELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRLLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAQETQGFQRTLETERQRQLEMSAEAERLRLRVAEMSRAQARAEEDAQRFRKQAEEISAKLHRTELATQEKVTLVQTLETQRQQSDRDADRLREAIAELEREKDKLKKEAELLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEEEKAKLERLFQDEVAKAQKLREEQQRQQQQMQQEKQQLLASMEEARRRQREAEEGVRRKQEELQLLEQQRQQQEQLLAEENRRLRERLEHLEEEHRAALAHSEEITAAQAAATRALPNGQDATDGPAAEPEHAFEGLRQKVPAQQLQEAGILSTEEVQRLVQGHTTVAELTQREDVRRYLQGHSSIAGLLLKPANEKLTIYAALRRQLLSPGTAVILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLQDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDQAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWELINSEYFTAEQRRDLLRQFRTGKVTVEKIIKIVITVIEEHEQKGQLCFQGLRALVPAAELLESGVIDWDLFRQLQLGERSVQEVAEVEAVRRALRGSGVIAGVWLEEARQKLSIYEALKKELLQPEAAVALLEAQAGTGHVIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYKDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRLPLDVACARGYLDKETSTALTAPRDDAKTYYNPRTWEPATYSQLQQQCRPDPLTGLSLLPLSEEAARARQQELYSEVQAREAFQKATVEVPVGSFQGRAVTIWELINSEYFTAEQRQELLRQFRTGKVTVEKIIKIIITIVEEVETTRRERLSFSGLRAPVPASELLASGILSSSQFEQLKDGKTSVKDLSELDSVRTLLQGSGCLAGIYLEESKEKVTIYEAMRRGLLRPSTAILLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDKEMNRVLEDPSDDTKGFFDPNTRENLTYRQLLERCVEDPETGLRLLPLKGPEKAEVVETTRVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIVRQQNLASYDYVRRRLTAEDLHEARVISRESYSLLREGTRSLREVLEAESAWRYLYGTGCVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGDRLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKDLIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYIDPSTDERLSYTQLLRRCRRDEASGLFLLPLSDARKLTFRGLRKQITVEELVRSHVMDEATAQRLQEGLTSIEEVSKNLQKFLEGTSSIAGVLVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVDVAYQRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCVTDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDEAIAKSLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAATQSSKGYYSPYSVSGSGSTTGSRSGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPTSSLGGPESTAA", "length": 4671, "header": "tr|E1BF59-1|E1BF59_BOVIN Isoform 1 of Plectin OS=Bos taurus OX=9913 GN=PLEC PE=1 SV=3 CANONICAL=E1BF59-1" }, "locus": { "chromosome": "14", "start_pos": 895531, "end_pos": 862943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015828.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015828.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015828.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015828.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 164, "start_aa": "Thr", "end_pos": 164, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr164", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 4660, "start_aa": "Thr", "end_pos": 4660, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4660", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-264870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264870", "resource": "Reactome", "description": "Caspase-mediated cleavage of cytoskeletal proteins" }, { "id": "R-BTA-446107", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446107", "resource": "Reactome", "description": "Type I hemidesmosome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "P30427-1", "protein_name": "Plectin", "gene_name": "Plec", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVAGMLMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMTSLKARGLVRETFAWCHFYWYLTNEGIDHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRRSPHVQTMQGPLGCPPKRGPLPAEDPAREERQVYRRKEREEGAPETPVVSATIVGTLARPGPEPTPATDERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFKISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKIPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLYQADSLLQSDIRLLASGKAAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLHDLLAWVEENQRRIDGAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRSITVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLLAVCDYKQVEVTVHKGDQCQLVGPAQPFHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQSLNRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEHLKEAQAVPATLQELEVTKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSSWLQDAKSRQEQIQAVPIANSQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEARELQRRMQEEVTRREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEDELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELKLQAEEAERWLCQAEAERARQVQVALETAQRSAEVELQSKRPSFAEKTAQLERTLQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLTEGTAQQRLAAEQELIRLRAETEQGEHQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEARRHRELAEEDAARQRAEADGVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKASFEKAAAGKAELELELGRIRSNAEDTMRSKELAEQEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQADKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDQDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLQEEQQRQQQQMEQEKQELVASMEEARRRQREAEEGVRRKQEELQRLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEEIATSQAAATKALPNGRDALDGPSMEAEPEYTFEGLRQKVPAQQLQEAGILSMEELQRLTQGHTTVAELTQREDVRHYLKGGSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIVITVVEEHERKGQLCFEGLRALVPAAELLDSGVISHEVYQQLQRGERSVREVAEADEVRQALRGTSVIAGVWLEEAGQKLSIYEALRRDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEMHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRALTSPRDDARVYLDPSTREPVTYSQLQQRCRSDQLTGLSLLPLSEKAVRARQEEVYSELQARETLEKAKVEVPVGGFKGRALTVWELISSEYFTEEQRQELLRQFRTGKVTVEKVIKILITIVEEVETQRQERLSFSGLRAPVPASELLASKILSRTQFEQLKDGKTSVKDLSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRASTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVLRDHAIRLLEAQIATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLRGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSDMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKSLREVLEMESAWRYLYGTGSVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQPISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDNSGQMLLPLSDARKLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIGDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISSAVPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPESAVA", "length": 4687 }, "evidence": [ { "id": "E1BF59", "url": "https://omabrowser.org/oma/group/E1BF59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15149-1", "protein_name": "Plectin", "gene_name": "PLEC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA", "length": 4684 }, "evidence": [ { "id": "E1BF59", "url": "https://omabrowser.org/oma/group/E1BF59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXS1-1", "protein_name": "Plectin", "gene_name": "Plec", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLKARGLVRETFAWCHFYWYLTNEGIDHLRQYLHLPPEIVPASLQRVRRPVAMVIPARRRSPHVQTMQGPLGCPPKRGPLPAEDPAREERQVYRRKEREEGAPETPVVSATTVGTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQAGQLKIPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLNQADALLQSDIRLLASGKVAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRTITVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLIAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLSGSSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQSLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKALPNGRDAPDGPSVEAEPEYTFEGLRQKVPAQQLQEAGILSQEELQRLAQGHTTVAELTQREDVYRYLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGVRLLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEMNRILSDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGRTVTIWEIINSEYFTAEQRRDLLQQFRTGHITVEKIIKIVITVVEEHERKGQLCFEGLRALVPAAELLDSGVISHELYQQLQRGERSVREVAEADSVRQALRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRALTSPRDDARVYHDPSTQEPVTYSQLQQRCRSDQLTGLSLLPLSEKAVRARQEEVYSELQARETLEQAKVEVPVGSFKGRAMTVWELISSEYFTEEQRQELLRQFRTGKVTVEKVIKIVITIVEEVETRRQERLSFSGLRAPVPASELLDAKILSRAQFDQLKDGKTSVKELSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGNTISLFQAMKKGLVLRDHAIRLLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLKGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSNMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKNLREVLEMESAWRYLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDPSGQMLLLLSDARKLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISSAGPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPESAVA", "length": 4691 }, "evidence": [ { "id": "E1BF59", "url": "https://omabrowser.org/oma/group/E1BF59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "dystroglycan binding", "id": "GO:0002162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002162", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "ankyrin binding", "id": "GO:0030506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 16, "go_terms": [ { "name": "podosome", "id": "GO:0002102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "hemidesmosome", "id": "GO:0030056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030056", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "myelin sheath", "id": "GO:0043209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043209", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton", "id": "GO:0045111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 32, "go_terms": [ { "name": "intermediate filament cytoskeleton organization", "id": "GO:0045104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045104", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "skeletal myofibril assembly", "id": "GO:0014866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014866", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "leukocyte migration involved in immune response", "id": "GO:0002522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002522", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "response to food", "id": "GO:0032094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032094", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "regulation of vascular permeability", "id": "GO:0043114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043114", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "transmission of nerve impulse", "id": "GO:0019226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019226", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "keratinocyte development", "id": "GO:0003334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003334", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "adherens junction organization", "id": "GO:0034332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034332", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "peripheral nervous system myelin maintenance", "id": "GO:0032287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032287", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "myoblast differentiation", "id": "GO:0045445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045445", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "fibroblast migration", "id": "GO:0010761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010761", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "respiratory electron transport chain", "id": "GO:0022904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022904", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "hemidesmosome assembly", "id": "GO:0031581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031581", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cellular response to hydrostatic pressure", "id": "GO:0071464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071464", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "T cell chemotaxis", "id": "GO:0010818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010818", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "cellular response to fluid shear stress", "id": "GO:0071498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071498", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "nucleus organization", "id": "GO:0006997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006997", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "actomyosin contractile ring assembly actin filament organization", "id": "GO:2000689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000689", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "tight junction organization", "id": "GO:0120193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120193", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" }, { "name": "protein-containing complex organization", "id": "GO:0043933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043933", "evidence": [ { "database": "UniProtKB", "id": "E1BF59", "url": "https://www.uniprot.org/uniprotkb/E1BF59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2985, "end_pos": 2987, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3644, "end_pos": 3646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4222, "end_pos": 4224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4429, "end_pos": 4431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF59" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 287, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 164, 4660 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2985, "end_pos": 2987 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 3644, "end_pos": 3646 }, { "start_pos": 4222, "end_pos": 4224 }, { "start_pos": 4429, "end_pos": 4431 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 732, "end_pos": 734 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 99 }, { "field": "total_sites", "count": 98 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1651 }, { "field": "total_sites", "count": 1376 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1616 }, { "field": "total_sites", "count": 1356 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 35 }, { "field": "total_sites", "count": 26 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 238 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BEH7-1", "uniprot_ac": "E1BEH7", "uniprot_id": "E1BEH7_BOVIN", "mass": { "chemical_mass": 50456.0, "monoisotopic_mass": 50456.0 }, "refseq": {}, "gene_names": [ { "name": "TC2N", "type": "recommended", "evidence": [ { "id": "E1BEH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH7" } ] } ], "protein_names": [ { "name": "Tandem C2 domains nuclear protein", "type": "recommended", "evidence": [ { "id": "E1BEH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH7/entry#names_and_taxonomy" } ] }, { "name": "Membrane targeting tandem C2 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "E1BEH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH7/entry#names_and_taxonomy" } ] }, { "name": "Tandem C2 protein in nucleus", "type": "synonym", "evidence": [ { "id": "E1BEH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEH7", "url": "https://www.uniprot.org/uniprotkb/E1BEH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TC2N", "url": "https://www.uniprot.org/uniprotkb/E1BEH7", "locus": { "chromosome": "21", "start_pos": 56489308, "end_pos": 56531661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003375", "url": "https://www.ensembl.org/id/ENSBTAG00000003375" } ] } } ], "crossref": [ { "id": "E1BEH7", "url": "https://alphafold.ebi.ac.uk/entry/E1BEH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003375", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003375", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08684", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08684", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BEH7", "url": "https://www.orthodb.org/?gene=E1BEH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46887", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46887", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46887:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46887:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJW7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJW7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEH7", "url": "https://www.uniprot.org/uniprotkb/E1BEH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEQKNTTPQVGCTEDYLLSKLPSDGKEVPFVVPRFKLSYIQPRMQGTPSQLEELEGSARASFGDRKAELSSSAQQGPSYDVYNPFYKYQHVSPDLSRRFPPRSEATRLYGSVCDLRTNRLPSSPGLSKSMFDLTSSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDWGRLNVKVFYNSSVEQIWITVLQCRDLSWPSRYGDTPTISVKGILTLPKPVHFKSSVKEGSNNIEFMETFVFSIKLQSLQTVRLVFKIQTQTPRKKTIGECSLSLRTLSTQEMDYSLDISPPSKISVCHAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKVAMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIIFLIKLYSRSSVGRRHFVGQIWISEDSNNTEAVSQWKETVTHPEKVVVKWHKLNPS", "length": 446, "header": "tr|E1BEH7-1|E1BEH7_BOVIN Isoform 1 of Tandem C2 domains nuclear protein OS=Bos taurus OX=9913 GN=TC2N PE=4 SV=2 CANONICAL=E1BEH7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEH7/entry#A0A3Q1LJW7-1", "sequence": { "sequence": "MATEFIKSCCRGCFYGGTEKHNLSVERDFKAAVSHSQNTTISIPPLTSVSVKPQVGCTEDYLLSKLPSDGKEVPFVVPRFKLSYIQPRMQGTPSQLEELEGSARASFGDRKAELSSSAQQGPSYDVYNPFYKYQHVSPDLSRRFPPRSEATRLYGSVCDLRTNRLPSSPGLSKSMFDLTSSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDWGRLNVKVFYNSSVEQIWITVLQCRDLSWPSRYGDTPTISVKGILTLPKPVHFKSSVKEGSNVCHAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKVAMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIIFLIKLYSRSSVGRRHFVGQIWISEDSNNTEAVSQWKETVTHPEKVVVKWHKLNPS", "length": 426, "header": "tr|A0A3Q1LJW7-1|E1BEH7_BOVIN Computationally mapped isoform of Tandem C2 domains nuclear protein OS=Bos taurus OX=9913 GN=TC2N PE=4 SV=1 CANONICAL=E1BEH7-1" }, "locus": { "chromosome": "21", "start_pos": 56518308, "end_pos": 56489908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059789.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059789.2" } ] } }, { "isoform_ac": "E1BEH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEH7/entry#E1BEH7-1", "sequence": { "sequence": "MVEQKNTTPQVGCTEDYLLSKLPSDGKEVPFVVPRFKLSYIQPRMQGTPSQLEELEGSARASFGDRKAELSSSAQQGPSYDVYNPFYKYQHVSPDLSRRFPPRSEATRLYGSVCDLRTNRLPSSPGLSKSMFDLTSSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDWGRLNVKVFYNSSVEQIWITVLQCRDLSWPSRYGDTPTISVKGILTLPKPVHFKSSVKEGSNNIEFMETFVFSIKLQSLQTVRLVFKIQTQTPRKKTIGECSLSLRTLSTQEMDYSLDISPPSKISVCHAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKVAMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIIFLIKLYSRSSVGRRHFVGQIWISEDSNNTEAVSQWKETVTHPEKVVVKWHKLNPS", "length": 446, "header": "tr|E1BEH7-1|E1BEH7_BOVIN Isoform 1 of Tandem C2 domains nuclear protein OS=Bos taurus OX=9913 GN=TC2N PE=4 SV=2 CANONICAL=E1BEH7-1" }, "locus": { "chromosome": "21", "start_pos": 56518265, "end_pos": 56489908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004377.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004377.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004377.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004377.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BEH7", "url": "https://www.uniprot.org/uniprotkb/E1BEH7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEH7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 446, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEH7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEH7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH7" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 179, "end_pos": 298, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJX2-1", "uniprot_ac": "E1BJX2", "uniprot_id": "E1BJX2_BOVIN", "mass": { "chemical_mass": 36532.0, "monoisotopic_mass": 36532.0 }, "refseq": { "ac": "XP_024832851", "name": "glutathione S-transferase, theta 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832851" }, "gene_names": [ { "name": "GSTT4", "type": "recommended", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] }, { "name": "GSTT4", "type": "synonym", "evidence": [ { "id": "XP_024832851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832851" } ] } ], "protein_names": [ { "name": "glutathione transferase", "type": "recommended", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.18", "type": "synonym", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#names_and_taxonomy" } ] }, { "name": "glutathione S-transferase, theta 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024832851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832851" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJX2", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GSTT4", "url": "https://www.uniprot.org/uniprotkb/E1BJX2", "locus": {} } ], "crossref": [ { "id": "E1BJX2", "url": "https://alphafold.ebi.ac.uk/entry/E1BJX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000170", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000170", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03183", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03183", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506093", "url": "https://www.ncbi.nlm.nih.gov/gene/506093", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKH5", "url": "https://www.orthodb.org/?gene=A0A3Q1LKH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLL0", "url": "https://www.orthodb.org/?gene=A0A3Q1LLL0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BJX2", "url": "https://www.orthodb.org/?gene=E1BJX2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43917:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43917:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00043", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00043", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024832851", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832851", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16437", "url": "https://www.rhea-db.org/rhea/16437", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKH5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLL0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLL0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVD3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVD3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1M8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1M8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1M8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJX2", "url": "https://www.uniprot.org/uniprotkb/E1BJX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJX2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGARPGWVGTGPGHRLRWAACGWASASRGGAQHGPGALPGPAVPVLPRRLHLRQEEQHPLRLPVCGSAERFFLTMMNGGQGGTVGTRRVPGLSPSAPAFSAAVQLPIRAAEVTGARVLIPHCHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQPMAGNHNVFLNSAKLAEWRMRVELAIGSTLFCEAHDRLVKLAEWDCSTLDPMVKERICDLLQKFK", "length": 326, "header": "tr|E1BJX2-1|E1BJX2_BOVIN Isoform 1 of glutathione transferase OS=Bos taurus OX=9913 GN=GSTT4 PE=3 SV=3 CANONICAL=E1BJX2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKH5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#A0A3Q1LKH5-1", "sequence": { "sequence": "MRGARPGWVGTGPGHRLRWAACGWASASRGGAQHGPGALPGPAVPVLPRRLHLRQEEQHPLRLPVCGSAERFFLTMMNGGQGGTVGTRRVPGLSPSAPAFSAAVQLPIRAAEVTGARVLIPHCHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQVSSGGRRTEQTRDSLETVTCREAGEGGAVPGCLALTWGNHGKPRLGTREDHGR", "length": 314, "header": "tr|A0A3Q1LKH5-1|E1BJX2_BOVIN Computationally mapped isoform of glutathione transferase OS=Bos taurus OX=9913 GN=GSTT4 PE=3 SV=2 CANONICAL=E1BJX2-1" }, "locus": { "chromosome": "17", "start_pos": 71314888, "end_pos": 71311741, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087399.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087399.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057162.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057162.2" } ] } }, { "isoform_ac": "A0A3Q1LLL0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#A0A3Q1LLL0-1", "sequence": { "sequence": "MDATQVEQLLGKLTPALGHLDQELLAARPFLASGQVSLEDLMAFTELMQFVDLLKGHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQVSSGGRRTEQTRDSLETVTCREAGEGGAVPGPGWEPGRIMVVSASGRVLRGDGSWRVSLLSQPGSQGPPPPKGPSRKNPEASKVSF", "length": 280, "header": "tr|A0A3Q1LLL0-1|E1BJX2_BOVIN Computationally mapped isoform of glutathione transferase OS=Bos taurus OX=9913 GN=GSTT4 PE=3 SV=2 CANONICAL=E1BJX2-1" }, "locus": { "chromosome": "17", "start_pos": 71315021, "end_pos": 71310680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081078.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081078.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060669.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060669.2" } ] } }, { "isoform_ac": "A0ABI0NVD3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#A0ABI0NVD3-1", "sequence": { "sequence": "MMNGGQGGTVGTRRVPGLSPSAPAFSAAVQLPIRAAEVTGARVLIPHCHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKGLSRWTTREVPHPSEQGPQAPSTHWNCQRRRYHFTSLLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQPMAGNHNVFLNSAKLAEWRMRVELAIGSTLFCEAHDRLVKLAEWDCSTLDPMVKERICDLLQKFK", "length": 288, "header": "tr|A0ABI0NVD3-1|A0ABI0NVD3_BOVIN Computationally mapped isoform of Glutathione S-transferase, theta 4 OS=Bos taurus OX=9913 GN=GSTT4 PE=4 SV=1 CANONICAL=E1BJX2-1" }, "locus": { "chromosome": "17", "start_pos": 71315979, "end_pos": 71312266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152594.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152594.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104198.1" } ] } }, { "isoform_ac": "A0ABI0P1M8-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#A0ABI0P1M8-1", "sequence": { "sequence": "MDATQVEQLLGKLTPALGHLDQELLAARPFLASGQVSLEDLMAFTELMQFVDLLKGHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQPMAGNHNVFLNSAKLAEWRMRVELAIGSTLFCEAHDRLVKLAEWDCSTLDPMVKERICDLLQKFK", "length": 259, "header": "tr|A0ABI0P1M8-1|A0ABI0P1M8_BOVIN Computationally mapped isoform of glutathione transferase OS=Bos taurus OX=9913 GN=GSTT4 PE=3 SV=1 CANONICAL=E1BJX2-1" }, "locus": { "chromosome": "17", "start_pos": 71315979, "end_pos": 71310680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153874.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153874.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104586.1" } ] } }, { "isoform_ac": "E1BJX2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX2/entry#E1BJX2-1", "sequence": { "sequence": "MRGARPGWVGTGPGHRLRWAACGWASASRGGAQHGPGALPGPAVPVLPRRLHLRQEEQHPLRLPVCGSAERFFLTMMNGGQGGTVGTRRVPGLSPSAPAFSAAVQLPIRAAEVTGARVLIPHCHHHSREYIEINPLRKLPSLRDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQLPMNKILWMKLLIPMITGDEVPAEKTEQMLAEVKNNLKLFEEKFLQDKMFITGDNISLADLVALVEMMQPMAGNHNVFLNSAKLAEWRMRVELAIGSTLFCEAHDRLVKLAEWDCSTLDPMVKERICDLLQKFK", "length": 326, "header": "tr|E1BJX2-1|E1BJX2_BOVIN Isoform 1 of glutathione transferase OS=Bos taurus OX=9913 GN=GSTT4 PE=3 SV=3 CANONICAL=E1BJX2-1" }, "locus": { "chromosome": "17", "start_pos": 71315979, "end_pos": 71311741, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000195.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000195.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000195.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000195.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "E1BJX2", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJX2", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "E1BJX2", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16437", "name": "", "equation": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "F1MUX5-1", "F1MX44-1", "A0ABI0P5M0-1", "A0AAA9TW47-1", "F6QEM8-1", "A0ABI0P3R2-1", "A0AAF6Z0W3-1", "P28801-1", "Q2KJG4-1", "A0A3Q1LMV5-1", "F1MVX2-1", "Q28035-1", "Q9N0V4-1", "Q2NL00-1", "F1MXY2-1", "E1BED9-1", "A0ABI0P006-1", "Q5E9G0-1", "Q64L89-1", "A0A452DIU1-1", "F1MGZ9-1", "A0AAA9TXU3-1", "E1BJX2-1" ], "evidence": [ { "id": "16437", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16437" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A452DIU1", "gene_name": "LOC327709", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TXU3", "gene_name": "GSTZ1", "activity": [ { "ec_number": "5.2.1.2", "activity": "4-maleylacetoacetate = 4-fumarylacetoacetate.", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "5.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] } ] }, { "uniprot_ac": "A0AAF6Z0W3", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] } ] }, { "uniprot_ac": "A0ABI0P006", "gene_name": "LOC785216", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] } ] }, { "uniprot_ac": "A0ABI0P3R2", "gene_name": "GSTT2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2.", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] } ] }, { "uniprot_ac": "A0ABI0P5M0", "gene_name": "GSTA1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] } ] }, { "uniprot_ac": "E1BED9", "gene_name": "GSTO2", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] } ] }, { "uniprot_ac": "E1BJX2", "gene_name": "GSTT4", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] } ] }, { "uniprot_ac": "F1MGZ9", "gene_name": "HPGDS", "activity": [ { "ec_number": "5.3.99.2", "activity": "prostaglandin H2 = prostaglandin D2.", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "5.3.99.2", "activity": "", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] } ] }, { "uniprot_ac": "F1MUX5", "gene_name": "LOC100295687", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUX5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUX5" } ] } ] }, { "uniprot_ac": "F1MVX2", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MVX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVX2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MVX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVX2" } ] } ] }, { "uniprot_ac": "F1MX44", "gene_name": "GSTA5", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX44" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX44" } ] } ] }, { "uniprot_ac": "F1MXY2", "gene_name": "MGST1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] } ] }, { "uniprot_ac": "F6QEM8", "gene_name": "LOC783879", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F6QEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QEM8" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F6QEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QEM8" } ] } ] }, { "uniprot_ac": "O18879", "gene_name": "GSTA2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "O18879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18879" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "O18879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18879" } ] } ] }, { "uniprot_ac": "P28801", "gene_name": "GSTP1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "P28801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P28801" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P28801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P28801" } ] } ] }, { "uniprot_ac": "Q28035", "gene_name": "GSTA1", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] } ] }, { "uniprot_ac": "Q2KJG4", "gene_name": "MGST2", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = leukotriene A4 + glutathione.", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] } ] }, { "uniprot_ac": "Q2NL00", "gene_name": "GSTT1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ] } ] }, { "uniprot_ac": "Q5E9G0", "gene_name": "GSTA4", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q5E9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q5E9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ] } ] }, { "uniprot_ac": "Q64L89", "gene_name": "MGST1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q64L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q64L89" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q64L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q64L89" } ] } ] }, { "uniprot_ac": "Q9N0V4", "gene_name": "GSTM1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q9N0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0V4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q9N0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0V4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJX2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJX2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJX2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" }, { "id": "PS50405", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50405" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GST C-terminal", "eco_id": "ECO_0000259", "start_pos": 173, "end_pos": 303, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" }, { "id": "PS50404", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50404" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GST N-terminal", "eco_id": "ECO_0000259", "start_pos": 81, "end_pos": 167, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.18", "ec_name": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "2.5.1.18", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18" }, { "id": "2.5.1.18", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.18" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 247, "end_pos": 249 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKR4-1", "uniprot_ac": "E1BKR4", "uniprot_id": "E1BKR4_BOVIN", "mass": { "chemical_mass": 79942.0, "monoisotopic_mass": 79942.0 }, "refseq": {}, "gene_names": [ { "name": "NOL10", "type": "recommended", "evidence": [ { "id": "E1BKR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" } ] } ], "protein_names": [ { "name": "Nucleolar protein 10", "type": "recommended", "evidence": [ { "id": "E1BKR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKR4", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOL10", "url": "https://www.uniprot.org/uniprotkb/E1BKR4", "locus": { "chromosome": "11", "start_pos": 87061973, "end_pos": 86971510, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002716", "url": "https://www.ensembl.org/id/ENSBTAG00000002716" } ] } } ], "crossref": [ { "id": "E1BKR4", "url": "https://alphafold.ebi.ac.uk/entry/E1BKR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002716", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002716", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516314", "url": "https://www.ncbi.nlm.nih.gov/gene/516314", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012580", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012580", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GYFMDVR", "url": "https://omabrowser.org/oma/group/GYFMDVR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LL72", "url": "https://www.orthodb.org/?gene=A0A3Q1LL72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQH0", "url": "https://www.orthodb.org/?gene=A0A3Q1MQH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKR4", "url": "https://www.orthodb.org/?gene=E1BKR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14927", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14927", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14927:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14927:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LL72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKR4", "url": "https://www.uniprot.org/uniprotkb/E1BKR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKR4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 688, "header": "tr|E1BKR4-1|E1BKR4_BOVIN Isoform 1 of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=3 CANONICAL=E1BKR4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL72-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0A3Q1LL72-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 662, "header": "tr|A0A3Q1LL72-1|E1BKR4_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=2 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087060.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087060.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057220.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057220.2" } ] } }, { "isoform_ac": "A0A3Q1MQH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0A3Q1MQH0-1", "sequence": { "sequence": "MSVVTGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 623, "header": "tr|A0A3Q1MQH0-1|A0A3Q1MQH0_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=2 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86980561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068432.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068432.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071998.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071998.2" } ] } }, { "isoform_ac": "A0AAA9S9A0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0AAA9S9A0-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 598, "header": "tr|A0AAA9S9A0-1|A0AAA9S9A0_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=1 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131115.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131115.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082651.1" } ] } }, { "isoform_ac": "A0AAA9SQR8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0AAA9SQR8-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 638, "header": "tr|A0AAA9SQR8-1|A0AAA9SQR8_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=1 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118369.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118369.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085298.1" } ] } }, { "isoform_ac": "A0AAA9STW0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0AAA9STW0-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 648, "header": "tr|A0AAA9STW0-1|A0AAA9STW0_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=1 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112103.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112103.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089860.1" } ] } }, { "isoform_ac": "A0AAA9TTF1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#A0AAA9TTF1-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKGACSFPRVSEFFIHKGASACSLPRARDTQNRQTWPWVSQSRGWREITYSHLIVIRSSRRSSRRLRNCTGRRGRLCAVRQAISGPGPGGGGHSTDSGAGPACDPEELSASPLPDRRSFVHVSHSRVWAALKSLGTLAFAERSPDRAVVPRPLVRLWGWARWPCGAPGHLCAVWLPENIIPSPWF", "length": 832, "header": "tr|A0AAA9TTF1-1|A0AAA9TTF1_BOVIN Computationally mapped isoform of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=1 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060974, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101632.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101632.1" } ] } }, { "isoform_ac": "E1BKR4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR4/entry#E1BKR4-1", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFETLSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRGRVGVLDCALSSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIIKMWNKNSGKIFTSLEPEHDLNDVCLYPSSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMLNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELHGKEEEEEPEGKPSDAESSESSDDEKDWVAEVRKQRRLLQQEEKVKRQEQLREDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKLEAKNGTLSVSDTTVGSKQLTFTLKKSEQQKKQQEAEKLHRQERKAVRRSAGHLRSRPRRGRPFH", "length": 688, "header": "tr|E1BKR4-1|E1BKR4_BOVIN Isoform 1 of Nucleolar protein 10 OS=Bos taurus OX=9913 GN=NOL10 PE=3 SV=3 CANONICAL=E1BKR4-1" }, "locus": { "chromosome": "11", "start_pos": 87060703, "end_pos": 86971608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003521.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003521.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003521.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003521.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E1BXP3-1", "protein_name": "Nucleolar protein 10", "gene_name": "NOL10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQVSSLNEVKIYSLSAGRSLPEWLSDRKKRALQKKDVDIRRRIELIQDFEMPTVSTKIKVSRDGQYIMAVGTYKPRIRCYDTYQLSQKFERCLDSEVVTFEILSDDYSKIVFLQCDRYVEFHSQHGHYYRTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRFLNSLPTDASENNVCDINPVHYLFATGTAEGKVECWDPRTRNRVGLLDCALSSVTADTEVDCLPSISALKFDGALNMAVGTSTGQVLLYDLRSSNPLIVKDHQYGLPIKSIQFQHQLDLIISADSRIIKMWNKDTGKIFTSMEPEYDINDVCLYPNSGMLMTANEAPRMNIYYMPVLGPAPKWCSFLDNLTEELEENPESTVYDDYKFVTRKDLENLGLAHLIGSSLLRAYMHGFFMDIRLYHKAKMMANPFAYEEYRREKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEGEEQQATRKRKQKNLPSLLKDDRFKVMFENPDFQVDEQSEEFRLLNPLVSKISEKRKKKLKLLQEQEAREQEEEEEPEGKPSDAESSESSDDEKGWVEEVRKQRKLLRQEEKVKRQERFKEDQQTLLKPQFFEIKEGEEFRSFKDSAKKQKLMKKTLGDRLKLEEKLGTLNVSDTTVGSKQATFKLKKSEHQKKQQEAEKQHRQERKALRRSASHLKSKHGRGQRFH", "length": 688 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HB02-1", "protein_name": "Nucleolar protein 10", "gene_name": "Nol10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINAVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTADSEINSLPTISALKFNGALTMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLVLSSDSRIVKMWNRNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANEAPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKATLKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSRISEKRKKQLRLLEQQELQAKNEEEEEPEGKPSDAESSESSDDEKAWVEEVRKQRRLLQQEERAQRRREQLEEDQETVLKPQFYEIKAGEEFRSFKESATKQRLMNKTLEDRLKLEAKHGTLNVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKKLRRSAGHLRSRPRRGRPFH", "length": 690 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P48234-1", "protein_name": "Ribosome biogenesis protein ENP2", "gene_name": "ENP2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVLKSTSANDVSVYQVSGTNVSRSLPDWIAKKRKRQLKNDLEYQNRVELIQDFEFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAENVDFTILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFFTANESIPMHTYYIPSLGPSPRWCSFLDSITEELEEKPSDTVYSNYRFITRDDVKKLNLTHLVGSRVLRAYMHGFFINTELYDKVSLIANPDAYKDEREREIRRRIEKERESRIRSSGAVQKPKIKVNKTLVDKLSQKRGDKVAGKVLTDDRFKEMFEDEEFQVDEDDYDFKQLNPVKSIKETEEGAAKRIRALTAAEESDEERIAMKDGRGHYDYEDEESDEEESDDETNQKSNKEELSEKDLRKMEKQKALIERRKKEKEQSERFMNEMKAGTSTSTQRDESAHVTFGEQVGELLEVENGKKSNESILRRNQRGEAELTFIPQRKSKKDGNYKSRRHDNSSDEEGIDENGNKKDNGRSKPRFENRRRASKNAFRGM", "length": 707 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54D60-1", "protein_name": "NUC153 domain-containing protein", "gene_name": "nol10", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLLTTNGVKIYNVSAGKSLPEWLSENKREELRKNKEFNQRIELIQDFSFETSSQRVRISQDGQYIMATGIYPPQFKVFELSQLSQKVSRNLDCNVVTFEMLSDDYSKPVFLRDDRYIEFHAKFGSYFKTRIPKLGRDMTYHKPSCDLYITASDTEVYRLNLEEGRFLAPLTTHLNGGINVIAQNPVHQLMMLGGENGFIECWDPRVRTMVSTINAAAALPDYNSADEDSEPISITAGKFGPDGLLLGLGTSNGGVLMYDIRSASPSMIKMHQYQLPINSINFHISGDGTQRIMSSDAKIFKSFEKDTGKIHMVLEPKNPITDVVVTNGSGLLLMPGNTQKIQTYYVPALGAAPRWCSFLDNLTEELEEDKQLVYEDYKFITRDEVAKLDIENLIGTGYLKAYMHGYFIHIKLYNKVVMSKNPTNYEDLRKQQIKDKLAEKNQTRISLTKKPTSSSSTTINKPAVNAKLAERLAAQYEIQKQDSHKPMDAEITQSSSSDPRFKAMFENRDFEQDEGSEAFLRVNPRSKISKLDKHIQDNFDKVDFDDEDSDDDNDDDDDDQDNYKNKNRNSDSEDSDDDDDYDEDDIKIKSNPITNKRKELQKEQIKSKKPIKMYEIKTGHSLPSLNGKESGKQQILKSAPFSVRVGKEIKKATGLDDKDEKDGTKITKKDNGDLEIAFIPSASKKNLNNKSKKVVKKK", "length": 699 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5RJG1-1", "protein_name": "Nucleolar protein 10", "gene_name": "Nol10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKNVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINAVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTADSEINSLPTISALKFNGALSMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLVLSADSRIVKMWNKDSGKIFTSLEPEHDLNDVCLYPSSGMLLTANESPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTLKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSRISEKRKKQLRLLEQQELKDEEEEEPEGKPSDAESSESSDDEKGWVEEVRKQRRLLQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQRLMNKTLEDRLKLEAKHGTLNVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKNLRRSASHLRSRPRRGRPFH", "length": 687 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q66H99-1", "protein_name": "Nucleolar protein 10", "gene_name": "Nol10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINTVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTADSEINSLPTISALKFNGALSMAVGTSTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLVLSADSRIVKMWNKDSGKIFTSLEPEHDLNDVCLYPSSGMILTANESPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTLKKKVKSLPNILTDDRFKVMFENPDFQVDEDSEEFRLLNPLVSRISEKRKKQLRLLEQQEQLKNEEEEEPEGKPSDAESSESSDDEKDWVEEVRKQRRLLQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEAKHGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKKLRRSASHLRSRPRRGRPFH", "length": 688 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BSC4-1", "protein_name": "Nucleolar protein 10", "gene_name": "NOL10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEGKPSDAESSESSDDEKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKIEAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKRLRRSAGHLKSRHKRGRSFH", "length": 688 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M1J9-1", "protein_name": "Embryo sac development arrest 7", "gene_name": "EDA7", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTSYGDRLKSTSINGVKLYNVSSAPNVPTWLNPKKQRALRKNPHYMQRVELIQELKFETATTRIKATPDGEYLIASGIYPPQVKVYELNQLALKFERHLDSEIVDFEILDDDFSKLAFLCADRSINLHAKYGKHHTLRIPRMGRDMTYDSWSCDLLCAASSPDLYRINLEQGRFLSPLSTQSPALNVVSRSNLHGLVACGGEDGAVEFFDMRMKSSAARINAVTHGGDAAAEVTAIEFDDSEGLQVAVGSSAGKVFIYDLRTSTPIRVKDHMYESPILNIKWQRTLNTQQPKLITTDKHIVRIWDPNTGEGMTSIEPTQGGINDICVFRGSGLMLLALDSSLIPSYFIPELGPAPKWCSPLENLTEELEESAQTTIYDNYKFLAMEDLEKLQLTHLIGTDLLKASMHGYFINYHLYKKALAVIEPFAFDDYLERRKQEKLEEQRTQRITKKRRLPKVNRDLAARLHGDESEEENKTAEDGEATKKVLKKKKPILTDEHFVDGRFGSMFQNPDFQIDKDSYEYGVLHPVASSKKQPSLLDEHFEAVSDDDENSDSDASQPSDDEADDGDATRPSKKARTPKLYEVKDERHAAAYHNRTSLAKEDSLPMGERVKAIENRRGNFGGSKDIKFGPGGSREFSFKARGSSKYKEDRDDEYEDGQRNKRRGVQSLGLKSTNIRGGFRGRGGGGFRGRGGGGSRGKGGRGGGRGRGRQ", "length": 711 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V3P2-1", "protein_name": "Nucleolar protein 10", "gene_name": "l(2)34Fd", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFVNEVNDVKIYNLSAGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQYILATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYRLRIPRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGTKEGTVEAWDPRTKQRCSTLDVAMKLPGVKEFPSVTALKFRNGLHMGVGTASGHVLIYDIRAKQPLLVKNHLNRLPIKRLAFNPAQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDTGMFFVAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHLVGSNLLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKSRLQIESKLPKVNKELALKIMDEQANPSNSAKQRNVPSLLEDSRFKAMFENADFEVNKSAEEYRLLAPVLNRLDKSKAKELKKRVEVAHVAELHADEAQQREESDNDEDLFGFEKSDGETKDDSGDEASSDDDDRREYVKEMKQAYKQVKRQREEEEELEDDEQQPDEISDTAKRPQTNGHSQQPTTNGNRFTMTPLDQHQGSSLLQQRIKKASLQDRVRVMSQLEGQVTNVGRSLGNRQMTFEVNKQKKSQFHAKKREAEMKKHREERRSIVRPIKSLRLKKVNFK", "length": 721 }, "evidence": [ { "id": "E1BKR4", "url": "https://omabrowser.org/oma/group/E1BKR4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BKR4", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "E1BKR4", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "E1BKR4", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 628, "end_pos": 630, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" }, { "id": "PF08159", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08159" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NUC153", "eco_id": "ECO_0000259", "start_pos": 482, "end_pos": 508, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" }, { "id": "PF23098", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 10-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 364, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR4" }, { "id": "PF23097", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 10-like second", "eco_id": "ECO_0000259", "start_pos": 369, "end_pos": 416, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 356, "end_pos": 358 }, { "start_pos": 615, "end_pos": 617 }, { "start_pos": 628, "end_pos": 630 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGL2-1", "uniprot_ac": "E1BGL2", "uniprot_id": "E1BGL2_BOVIN", "mass": { "chemical_mass": 115882.0, "monoisotopic_mass": 115882.0 }, "refseq": { "ac": "NP_001193213", "name": "granule associated Rac and RHOG effector protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193213" }, "gene_names": [ { "name": "GARRE1", "type": "recommended", "evidence": [ { "id": "E1BGL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ] }, { "name": "GARRE1", "type": "synonym", "evidence": [ { "id": "NP_001193213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193213" } ] }, { "name": "KIAA0355", "type": "synonym", "evidence": [ { "id": "NP_001193213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193213" } ] } ], "protein_names": [ { "name": "Granule associated Rac and RHOG effector 1", "type": "synonym", "evidence": [ { "id": "E1BGL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL2/entry#names_and_taxonomy" } ] }, { "name": "granule associated Rac and RHOG effector protein 1", "type": "synonym", "evidence": [ { "id": "NP_001193213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193213" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GARRE1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2", "locus": { "chromosome": "18", "start_pos": 44776252, "end_pos": 44723274, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013175", "url": "https://www.ensembl.org/id/ENSBTAG00000013175" } ] } } ], "crossref": [ { "id": "E1BGL2", "url": "https://alphafold.ebi.ac.uk/entry/E1BGL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013175", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013175", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617808", "url": "https://www.ncbi.nlm.nih.gov/gene/617808", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043385", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043385", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617808", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617808", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAQWPGI", "url": "https://omabrowser.org/oma/group/LAQWPGI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGL2", "url": "https://www.orthodb.org/?gene=E1BGL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15703", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15703", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15703:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15703:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193213", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLM2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV91", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTTPLGSLTAAGSCHHSMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANLTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTQALQKVQPVAHSCFAEVVVPEKKNSSSGGGLSGAGHTSELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSSFLKGVSFNESAADNLKLKTHTMLQLIKEAGCYNGMTPRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLTRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCPSSSSNTSYSIPNTPSKNIFIAGCSEEKAKMPTNMDSRLQSILNIGNFPRTADPSQSAQNSSNHMANGFLLERRDNFLQGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSAATAMVTEQKAGAMQPQQPSLPVPPPSRPPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPVGPQHPPPQPRAPGKWVPGSSQQPAQPVGAGLSPLGQWPGISDLSSDLYSLGLVSSCLDDVMSEVLGQKAQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQVQHGRRPGNPRGHWPPMDDAHRTWPFPEFFAEGDGLHSGWAGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQETSALPSPPLLTAVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPGPSAPLYAVASPGSQWSDTMQMLQSPVWAATSDCSAAASFAYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 1071, "header": "tr|E1BGL2-1|E1BGL2_BOVIN Isoform 1 of Granule associated Rac and RHOG effector 1 OS=Bos taurus OX=9913 GN=GARRE1 PE=4 SV=2 CANONICAL=E1BGL2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2/entry#A0A3Q1LLM2-1", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTTPLGSLTAAGSCHHSMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANLTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTQALQKVQPVAHSCFAEVVVPEKKNSSSGGGLSGAGHTSELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQHTMLQLIKEAGCYNGMTPRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLTRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCPSSSSNTSYSIPNTPSKNIFIAGCSEEKAKMPTNMDSRLQSILNIGNFPRTADPSQSAQNSSNHMANGFLLERRDNFLQGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSAATAMVTEQKAGAMQPQQPSLPVPPPSRPPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPVGPQHPPPQPRAPGKWVPGSSQQPAQPVGAGLSPLGQWPGISDLSSDLYSLGLVSSCLDDVMSEVLGQKAQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQVQHGRRPGNPRGHWPPMDDAHRTWPFPEFFAEGDGLHSGWAGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQETSALPSPPLLTAVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPGPSAPLYAVASPGSQWSDTMQMLQSPVWAATSDCSAAASFAYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 985, "header": "tr|A0A3Q1LLM2-1|E1BGL2_BOVIN Computationally mapped isoform of Granule associated Rac and RHOG effector 1 OS=Bos taurus OX=9913 GN=GARRE1 PE=4 SV=1 CANONICAL=E1BGL2-1" }, "locus": { "chromosome": "18", "start_pos": 44773974, "end_pos": 44724068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077960.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077960.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057485.1" } ] } }, { "isoform_ac": "A0A3Q1LV91-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2/entry#A0A3Q1LV91-1", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTTPLGSLTAAGSCHHSMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANLTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTQALQKVQPVAHSCFAEVVVPEKKNSSSGGGLSGAGHTSELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSSFLKGVSFNESAADNLKLKTHTMLQLIKEAGCYNGMTPRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLTRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCPSSSSNTSYSIPNTPSKNIFIAGCSEEKAKMPTNMDSRLQSILNIGNFPRTADPSQSAQNSSNHMANGFLLERRDNFLQGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSAATAMVTEQKAGAMQPQQPSLPVPPPSRPPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPVGPQHPPPQPRAPGKWVPGSSQQPAQPVGAGLSPLGQWPGISDLSSDLYSLGLVSSCLDDVMSEVLGQKAQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQVQHGRRPGNPRGHWPPMDDAHRTWPFPEFFAEGKHSSGEQETSALPSPPLLTAVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPGPSAPLYAVASPGSQWSDTMQMLQSPVWAATSDCSAAASFAYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 1025, "header": "tr|A0A3Q1LV91-1|A0A3Q1LV91_BOVIN Computationally mapped isoform of Granule associated Rac and RHOG effector 1 OS=Bos taurus OX=9913 GN=GARRE1 PE=4 SV=1 CANONICAL=E1BGL2-1" }, "locus": { "chromosome": "18", "start_pos": 44773974, "end_pos": 44724068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068596.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068596.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064526.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064526.2" } ] } }, { "isoform_ac": "A0A3Q1LZW8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2/entry#A0A3Q1LZW8-1", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTTPLGSLTAAGSCHHSMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANLTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTQALQKVQPVAHSCFAEVVVPEKKNSSSGGGLSGAGHTSELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQHTMLQLIKEAGCYNGMTPRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLTRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCPSSSSNTSYSIPNTPSKNIFIAGCSEEKAKMPTNMDSRLQSILNIGNFPRTADPSQSAQNSSNHMANGFLLERRDNFLQGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSAATAMVTEQKAGAMQPQQPSLPVPPPSRPPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPVGPQHPPPQPRAPGKWVPGSSQQPAQPVGAGLSPLGQWPGISDLSSDLYSLGLVSSCLDDVMSEVLGQKAQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQVQHGRRPGNPRGHWPPMDDAHRTWPFPEFFAEGDGLHSGWAGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQETSALPSPPLLTAVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPGPSAPLYAVASPGSQWSDTMQMLQSPVWAATSDCSAAASFAYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 1017, "header": "tr|A0A3Q1LZW8-1|A0A3Q1LZW8_BOVIN Computationally mapped isoform of Granule associated Rac and RHOG effector 1 OS=Bos taurus OX=9913 GN=GARRE1 PE=4 SV=1 CANONICAL=E1BGL2-1" }, "locus": { "chromosome": "18", "start_pos": 44773974, "end_pos": 44724068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070466.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070466.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063215.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063215.2" } ] } }, { "isoform_ac": "E1BGL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL2/entry#E1BGL2-1", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTTPLGSLTAAGSCHHSMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANLTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTQALQKVQPVAHSCFAEVVVPEKKNSSSGGGLSGAGHTSELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSSFLKGVSFNESAADNLKLKTHTMLQLIKEAGCYNGMTPRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLTRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCPSSSSNTSYSIPNTPSKNIFIAGCSEEKAKMPTNMDSRLQSILNIGNFPRTADPSQSAQNSSNHMANGFLLERRDNFLQGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSAATAMVTEQKAGAMQPQQPSLPVPPPSRPPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPVGPQHPPPQPRAPGKWVPGSSQQPAQPVGAGLSPLGQWPGISDLSSDLYSLGLVSSCLDDVMSEVLGQKAQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQVQHGRRPGNPRGHWPPMDDAHRTWPFPEFFAEGDGLHSGWAGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQETSALPSPPLLTAVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPGPSAPLYAVASPGSQWSDTMQMLQSPVWAATSDCSAAASFAYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 1071, "header": "tr|E1BGL2-1|E1BGL2_BOVIN Isoform 1 of Granule associated Rac and RHOG effector 1 OS=Bos taurus OX=9913 GN=GARRE1 PE=4 SV=2 CANONICAL=E1BGL2-1" }, "locus": { "chromosome": "18", "start_pos": 44773974, "end_pos": 44724068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017535.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017535.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017535.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017535.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617808", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617808", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8XFB5-1", "protein_name": "Granule associated Rac and RHOG effector 1", "gene_name": "Garre1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTAPSAPLGSLTTAGSCHHAMPHSTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAAMQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANFTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTHALQKVQPVAHSCFAEVVVPEKKNSSSLSGMGHTPELEEAVRSWRGAAEATSRLRERGCDGRLAGIEVQQLFCSQSAAIPEHQLKELNLKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSHFLKGVSFNESAADNLKLKTHTMFQLIKEAGCYDGITPRDDLPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLNRWRTGREQALPCIQIQLQRDICDFGNQADLPSGNGSKSSGLQKTFSKLTSRFTKKVSCTNSGSTHYSKTIFTAGCSEEKAKMLGSNIDTRLQSILNIGNFPRTTDPSQSSQNSRNPMVNGFLLERRENFLHGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRRNSTATAMVTEQKTGTMQPQQPSLPLAPPLRPPQAGAHTPLAAQQGLAPQQQSPKQQQPQVQFYQHLLQPIGSQQTPPQSRAPGKWGHGSSQHPSQPMAAGLSPLGQWPGISDLSSDLYSLGLVSSYMDNMMSEVLGQKPQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQAQHGRRPGNPRGNWPPMDDAHRTWPLPEFFTEGDSLHSGWSGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQETSTLPSPPLLTTVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPSPAAPLYAVASPGSQWNDTMQMLQSPVWAAASDCNTTSFTYVQTPPQPPPPPAHKAAPKGFKAFPGKAERRPAYLPQY", "length": 1060 }, "evidence": [ { "id": "E1BGL2", "url": "https://omabrowser.org/oma/group/E1BGL2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y1I7-1", "protein_name": "Granule associated Rac and RHOG effector 1", "gene_name": "GARRE1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYCCSAQESKMDYKRRFLLGGSKQKVQQHQQYQMPELGRTLSAPLASTAPASPLVSSAAAGSCNHPVSHTTPIADIQQGISKYLDALNVFCRTSTFLTDLFSSVFRNSHYSKAAMQLKDVQEHVMEAASRLTAAIKPEIAKMLMELSAGAANFKDQKEFSLQDIEVLGRCFLTVMQVHFQFLSQALQKVQPVAHSCFAEAVAQERKNVGGAGASNLSPTNELEDAVRSWRGAAEATSRLRERGCDGCLAGIEVQQLFCSQSVAIPEHQLKELNMKIDSALQAYKVALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPIQCELPTVPVQIGPHFLKGISFNESAAENLKLKTHTMLQLIKEAGCHNGLTPRDDSPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVFDIPRWKEGREQALPCIQIQLQREISDFGNQVDMPSGNGSKSSGGLQKTFSKLTSRFTKKTSCTSTSNTGSYSIPSTPSKNVFISSSSEEKAKMPTNIDARLQSILNIGNFPRTTDSLQSIQSTNNQIVNGFLVERQDNFFKLDEGKDDKGMNLPTDQEMQDVIDFLSGFNMGKSQQTSPMVKRRNSIASSTATEQKSGTVQQQPQSVSHTPLHPSQQGLSQQQQSQKQQQQMQYYQHLLQPIGPQQRVPAKWLTNSSQQPAQTVGAGLSHLNQWNNPGFSDLSSDLYSLGLVSSYMDNMMSEMLGQKPQGPRNNTWPNRDQTDGVFGMLGEILPFDPAVGSDPEFARYVAGVNQAMQQKRQAQHVRRPSNTRSNWLLPDDPHKTWPFPEYFTESDVTNSWSGTQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQEPSTLPSPPLLSAVDDRNQDNKTKTWPPKAPWQHTSSVTNTLPSQSTSLYPMSSPVSQWSDTMQILQSPVWAAANDCAPSTGISSSFAYAQQQQSQQQASQHKQMNKGFKSFPVKHERRPSYLHQY", "length": 1058 }, "evidence": [ { "id": "E1BGL2", "url": "https://omabrowser.org/oma/group/E1BGL2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O15063-1", "protein_name": "Granule associated Rac and RHOG effector protein 1", "gene_name": "GARRE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTAPLGSLTAAGSCHHAMPHTTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAATQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANFTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTHALQKVQPVAHSCFAEVIVPEKKNSGSGGGLSGMGHTPEVEEAVRSWRGAAEATSRLRERGCDGCLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSHFLKGVSFNESAADNLKLKTHTMLQLMKEAGCYNGITSRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLNRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCTSSSSSTNYSIQNTPSKNIFIAGCSEEKAKMPGNIDTRLQSILNIGNFPRTTDPSQSAQNSSNTVANGFLMERRENFLHGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRHNSAATAMVTEQKAGAMQPQQPSLPVPPPPRAPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPIGPQQPPPQPRAPGKWVHGSSQQPAQAVGAGLSPLGQWPGISDLSSDLYSLGLVSSYMDNVMSEVLGQKPQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQAQHGRRPGNPRGNWPPMDDAHRTWPFPEFFTEGDGLHGGWSGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQDTSTLPSPPLLTTVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPSPSAPLYAVTSPGSQWNDTMQMLQSPVWAATNDCSAAAFSYVQTPPQPPPPPAHKAAPKGFKAFPGKGERRPAYLPQY", "length": 1070 }, "evidence": [ { "id": "E1BGL2", "url": "https://omabrowser.org/oma/group/E1BGL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Rac protein signal transduction", "id": "GO:0016601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016601", "evidence": [ { "database": "UniProtKB", "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ], "pmid": "" }, { "name": "CCR4-NOT complex binding", "id": "GO:1905762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905762", "evidence": [ { "database": "UniProtKB", "id": "E1BGL2", "url": "https://www.uniprot.org/uniprotkb/E1BGL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 815, "end_pos": 817, "annotation": "n_glycosylation_sequon" }, { "start_pos": 970, "end_pos": 972, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGL2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1071, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGL2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGL2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 526, "end_pos": 528 }, { "start_pos": 555, "end_pos": 557 }, { "start_pos": 609, "end_pos": 611 }, { "start_pos": 815, "end_pos": 817 }, { "start_pos": 970, "end_pos": 972 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKD2-1", "uniprot_ac": "E1BKD2", "uniprot_id": "E1BKD2_BOVIN", "mass": { "chemical_mass": 139627.0, "monoisotopic_mass": 139627.0 }, "refseq": { "ac": "XP_010802153", "name": "ubiquitin carboxyl-terminal hydrolase 40 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802153" }, "gene_names": [ { "name": "USP40", "type": "recommended", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ] }, { "name": "USP40", "type": "synonym", "evidence": [ { "id": "XP_010802153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802153" } ] } ], "protein_names": [ { "name": "Ubiquitin carboxyl-terminal hydrolase 40", "type": "recommended", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#names_and_taxonomy" } ] }, { "name": "Deubiquitinating enzyme 40", "type": "synonym", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin thioesterase 40", "type": "synonym", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin-specific-processing protease 40", "type": "synonym", "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin carboxyl-terminal hydrolase 40 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_010802153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802153" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USP40", "url": "https://www.uniprot.org/uniprotkb/E1BKD2", "locus": { "chromosome": "3", "start_pos": 113167926, "end_pos": 113257513, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000149", "url": "https://www.ensembl.org/id/ENSBTAG00000000149" } ] } } ], "crossref": [ { "id": "E1BKD2", "url": "https://alphafold.ebi.ac.uk/entry/E1BKD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000149", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02659", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02659", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531139", "url": "https://www.ncbi.nlm.nih.gov/gene/531139", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531139", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531139", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLS6", "url": "https://www.orthodb.org/?gene=A0A3Q1LLS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCE2", "url": "https://www.orthodb.org/?gene=A0A3Q1MCE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKD2", "url": "https://www.orthodb.org/?gene=E1BKD2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006:SF842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006:SF842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010802153", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802153", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLS6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKD2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGDLFEEDYSSVSNNNGKGKRLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGLEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQKAVSTADLTDSFGWTSDEEMRQHDVQELNRILFSALETSLVGTSGHDLINRLYHGTIVNQIVCKECKNVSEKQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGNCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEDKSKPDVNLEDIQNKEEVDDPLMILKAILLQEESNLIPVDQLGQKLLKKIGISWNKKYRKQYGPLRKFLQVHSQIFLLSSDESTVRLLKDSSLQAESDIQRNDQRLFKTLTSESLTLNDRPSCPHWFDINDSTVQPIKEKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYKVPCHLLSEMDAANIELQIKRAECDSTNNTIELHLHLGPHYHFFNGALHPVVSQTESMWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKFVPAGLHVCQTLNGDDLALCEIEITDGEDIFVWNGVEVGGIQIPTGSDCEPLLLNVLHVATSSEGEECQQLIESPHVFPSNAEIGTVFTALAIPEGVILINNTESRGGESWITIPKEDLKKTFREQGLRNGSSVLIQGSNNGNSLLTKQGKWIDTVNEINWLQVRNLSQLESEEEQVKISATLNTVVFDIRIKAIKELKLLKELAENSCLRPIDRNGKLLCPVPDRCTLKEAGLKMGSSLGLCPGKAPTSSQLFLFFALGSDVHPGTEMEIIVEETISVRDCLKIMLDKCGLTGETWHLRKMDWCFEAGEPLCEEDAKLKELMICSGDTLLLIEGKLPPLGFLTVPIWWYQPQGPLHHWKDHQDQTNCTLSQGSVWKASSTPGAPSDAHAEVSLWYLGDLEISEDATLGELKSQAMTLPSLEFSIPSPAFLRAWTVENKRPGRLLRGHQQQLKEYKLGKRTEICLEPLQKEENLGPWDVLLRTQMRLPGKRAYGPPVDVLWDTARGWTASSLRQRVADVYSLPVEKIEIAKYFPDKFAWLPVSSWSQQTTKRKKKKKQDNLQGAPYYLKDGDTIGVKNLLVEDDDDFSTVQDDIGREKLKEVALGKRKSREALRAQSSDVSSVEMPAQARGPEASLSIHVGSFR", "length": 1233, "header": "tr|E1BKD2-1|E1BKD2_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 40 OS=Bos taurus OX=9913 GN=USP40 PE=3 SV=2 CANONICAL=E1BKD2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLS6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#A0A3Q1LLS6-1", "sequence": { "sequence": "MFGDLFEEDYSSVSNNNGKGKRLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGLEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQKAVSTADLTDSFGWTSDEEMRQHDVQELNRILFSALETSLVGTSGHDLINRLYHGTIVNQIVCKECKNVSEKQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGNCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEDKSKPDVNLEDIQNKEEVDDPLMILKAILLQEESNLIPVDQLGQKLLKKIGISWNKKYRKQYGPLRKFLQVHSQIFLLSSDESTVRLLKDSSLQAESDIQRNDQRLFKTLTSESLTLNDRPSCPHWFDINDSTVQPIKEKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYKVPCHLLSEMDAANIELQIKRAECDSTNNTIELHLHLGPHYHFFNGALHPVVSQTESMWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKFVPAGLHVCQTLNGDDLALCEIEITDGEDIFVWNGVEVGGIQIPTGSDCEPLLLNVLHVATSSEGEECQQLIESPHVFPSNAEIGTVFTALAIPEGVILINNTESRGGESWITIPKEDLKKTFREQGLRNGSSVLIQGSNNGNSLLTKQGKWIDTVNEINWLQVRNLSQLESEEEQVKISATLNTVVFDIRIKAIKELKLLKELAENSCLRPIDRNGKLLCPVPDRCTLKEAGLKMGSSLGLCPGKAPTSSQLFLFFALGSDVHPGTEMEIIVEETISVRDCLKIMLDKCGLTGETWHLRKMDWCFEAGEPLCEEDAKLKELMICSGDTLLLIEGKLPPLGFLTVPIWWYQPQGPLHHWKDHQDQTNCTLSQGSVWKASSTPGAPSDAHAEVSLWYLGDLEISEDATLGELKSQAMTLPSLEFSIPSPAFLRAWTVENKRPGRLLRGHQQQLKEYKLGKRTEICLEPLQKEENLGPWDVLLRTQMRLPGKRAYGPPVDVLWDTARGWTASSLRQRVADVYSLPVEKIEIAKYFPDKFAWLPVSSWSQQTTKRKKKKKQDNLQGAPYYLKDGDTIGVKNLLVEDDDDFSTVQDDIGREKLKEVALGKRKRCANFSLALPAWILPQDPVCLRPQCLLHPRAVSPCCLCPRSVCLLPWSLPTSLQRLPEYPQHLPTSPKCSVWSECATLGRTCRSDRDVW", "length": 1286, "header": "tr|A0A3Q1LLS6-1|E1BKD2_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase 40 OS=Bos taurus OX=9913 GN=USP40 PE=3 SV=2 CANONICAL=E1BKD2-1" }, "locus": { "chromosome": "3", "start_pos": 113256236, "end_pos": 113168447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073478.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073478.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057553.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057553.2" } ] } }, { "isoform_ac": "A0A3Q1MCE2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#A0A3Q1MCE2-1", "sequence": { "sequence": "MFGDLFEEDYSSVSNNNGKGKRLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGLEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQKAVSTADLTDSFGWTSDEEMRQHDVQELNRILFSALETSLVGTSGHDLINRLYHGTIVNQIVCKECKNVSEKQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGNCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEDKSKPDVNLEDIQNKEEVDDPLMILKAILLQEESNLIPVDQLGQKLLKKIGISWNKKYRKQYGPLRKFLQVHSQIFLLSSDESTVRLLKDSSLQAESDIQRNDQRLFKTLTSESLTLNDRPSCPHWFDINDSTVQPIKEKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYKVPCHLLSEMDAANIELQIKRAECDSTNNTIELHLHLGPHYHFFNGALHPVVSQTESMWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKFVPAGLHVCQTLNGDDLALCEIEITDGEDIFVWNGVEVGGIQIPTGSDCEPLLLNVLHVATSSEGEECQQLIESPHVFPSNAEIGTVFTALAIPEGVILINNTESRGGESWITIPKEDLKKTFREQGLRNGSSVLIQGSNNGNSLLTKQGKWIDTVNEINWLQVRNLSQLESEEEQVKISATLNTVVFDIRIKAIKELKLLKELAENSCLRPIDRNGKLLCPVPDRCTLKEAGLKMGSSLGLCPGKAPTSSQLFLFFALGSDVHPGTEMEIIVEETISVRDCLKIMLDKCGLTGETWHLRKMDWCFEAGEPLCEEDAKLKELMICSGDTLLLIEGKLPPLGFLTVPIWWYQPQGPLHHWKDHQDQTNCTLSQGSVWKASSTPGAPSDAHAEVSLWYLGDLEISEDATLGELKSQAMTLPSLEFSIPSPAFLRAWTVENKRPGRLLRGHQQQLKEYKLGKRTEICLEPLQKEENLGPWDVLLRTQMRLPGKRAYGPPVDVLWDTARGWTASSLRQRVADVYSLPVEKIEIAKYFPDKFAWLPVSSWSQQTTKRKKKKKQDNLQGAPYYLKDGDTIGVKNLLVEDDDDFSTVQDDIGREKLKEVALGKRKRRRQNRRQKPSSRLCVRHELRAGRYGSSCVLRSWTLASASGSPAPTPSQETQATLQSAQWAGTMP", "length": 1262, "header": "tr|A0A3Q1MCE2-1|A0A3Q1MCE2_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase 40 OS=Bos taurus OX=9913 GN=USP40 PE=3 SV=2 CANONICAL=E1BKD2-1" }, "locus": { "chromosome": "3", "start_pos": 113256236, "end_pos": 113175166, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073057.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073057.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068489.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068489.2" } ] } }, { "isoform_ac": "E1BKD2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKD2/entry#E1BKD2-1", "sequence": { "sequence": "MFGDLFEEDYSSVSNNNGKGKRLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGLEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQKAVSTADLTDSFGWTSDEEMRQHDVQELNRILFSALETSLVGTSGHDLINRLYHGTIVNQIVCKECKNVSEKQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGNCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEDKSKPDVNLEDIQNKEEVDDPLMILKAILLQEESNLIPVDQLGQKLLKKIGISWNKKYRKQYGPLRKFLQVHSQIFLLSSDESTVRLLKDSSLQAESDIQRNDQRLFKTLTSESLTLNDRPSCPHWFDINDSTVQPIKEKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYKVPCHLLSEMDAANIELQIKRAECDSTNNTIELHLHLGPHYHFFNGALHPVVSQTESMWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKFVPAGLHVCQTLNGDDLALCEIEITDGEDIFVWNGVEVGGIQIPTGSDCEPLLLNVLHVATSSEGEECQQLIESPHVFPSNAEIGTVFTALAIPEGVILINNTESRGGESWITIPKEDLKKTFREQGLRNGSSVLIQGSNNGNSLLTKQGKWIDTVNEINWLQVRNLSQLESEEEQVKISATLNTVVFDIRIKAIKELKLLKELAENSCLRPIDRNGKLLCPVPDRCTLKEAGLKMGSSLGLCPGKAPTSSQLFLFFALGSDVHPGTEMEIIVEETISVRDCLKIMLDKCGLTGETWHLRKMDWCFEAGEPLCEEDAKLKELMICSGDTLLLIEGKLPPLGFLTVPIWWYQPQGPLHHWKDHQDQTNCTLSQGSVWKASSTPGAPSDAHAEVSLWYLGDLEISEDATLGELKSQAMTLPSLEFSIPSPAFLRAWTVENKRPGRLLRGHQQQLKEYKLGKRTEICLEPLQKEENLGPWDVLLRTQMRLPGKRAYGPPVDVLWDTARGWTASSLRQRVADVYSLPVEKIEIAKYFPDKFAWLPVSSWSQQTTKRKKKKKQDNLQGAPYYLKDGDTIGVKNLLVEDDDDFSTVQDDIGREKLKEVALGKRKSREALRAQSSDVSSVEMPAQARGPEASLSIHVGSFR", "length": 1233, "header": "tr|E1BKD2-1|E1BKD2_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 40 OS=Bos taurus OX=9913 GN=USP40 PE=3 SV=2 CANONICAL=E1BKD2-1" }, "locus": { "chromosome": "3", "start_pos": 113256236, "end_pos": 113176677, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000172.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000172.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000172.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000172.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 970, "start_aa": "Thr", "end_pos": 970, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr970", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531139", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531139", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BKD2", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 690, "end_pos": 692, "annotation": "n_glycosylation_sequon" }, { "start_pos": 719, "end_pos": 721, "annotation": "n_glycosylation_sequon" }, { "start_pos": 755, "end_pos": 757, "annotation": "n_glycosylation_sequon" }, { "start_pos": 956, "end_pos": 958, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKD2" }, { "id": "PS50235", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50235" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "USP", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 482, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 970 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 193, "end_pos": 195 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 452, "end_pos": 454 }, { "start_pos": 524, "end_pos": 526 }, { "start_pos": 690, "end_pos": 692 }, { "start_pos": 719, "end_pos": 721 }, { "start_pos": 755, "end_pos": 757 }, { "start_pos": 956, "end_pos": 958 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE55-1", "uniprot_ac": "E1BE55", "uniprot_id": "E1BE55_BOVIN", "mass": { "chemical_mass": 123557.0, "monoisotopic_mass": 123557.0 }, "refseq": { "ac": "XP_005208533", "name": "SURP and G-patch domain-containing protein 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208533" }, "gene_names": [ { "name": "SUGP2", "type": "recommended", "evidence": [ { "id": "E1BE55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ] }, { "name": "SUGP2", "type": "synonym", "evidence": [ { "id": "XP_005208533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208533" } ] } ], "protein_names": [ { "name": "SURP and G-patch domain containing 2", "type": "synonym", "evidence": [ { "id": "E1BE55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE55/entry#names_and_taxonomy" } ] }, { "name": "SURP and G-patch domain-containing protein 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005208533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208533" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUGP2", "url": "https://www.uniprot.org/uniprotkb/E1BE55", "locus": { "chromosome": "7", "start_pos": 4211542, "end_pos": 4183434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013288", "url": "https://www.ensembl.org/id/ENSBTAG00000013288" } ] } } ], "crossref": [ { "id": "E1BE55", "url": "https://alphafold.ebi.ac.uk/entry/E1BE55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013288", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013288", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516567", "url": "https://www.ncbi.nlm.nih.gov/gene/516567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KAKRYHI", "url": "https://omabrowser.org/oma/group/KAKRYHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BE55", "url": "https://www.orthodb.org/?gene=E1BE55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23340:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23340:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208533", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMP4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMP4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE55-1", "url": "https://www.uniprot.org/uniprotkb/E1BE55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARRIAQETFDAVLQEKANRYMDPSGEAVGETLQFKAQDLLRTVPRARADMFDDIHSDSRYTLGTSVTHPRDTGREGLRGDIFPGPSFRSNNPSVSEDSYFRKECGRDLEFSHPNSRDQVFGHRKLGHFRSQDWKFALHGSWEQDFAHSVSQESSWSQEYSFGPSALLGNFGSSRLIEKECLEKESHDYDGDRPGEADSVLRGSSQAQGRGRGLNLADQEGAVLGKGETQGLLTSKVGVGKLVMLRNVSTKKVPTMSRITPKTQGTNQIQKTTSSPDVTLATNPGTEVQFPTRKVPLGLDLKDVRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDVKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLTNPLDLAIALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKTESEPTRDEEKAVPSTKPEIQAQALSGLSDGPMWSRVFLREDPLCVPEVPQRADHKVVDIIDQLVARVIGGSLSPKERALLQEDPAYWFLSDDSSLEYKYYKLKLAEMQRMSQTLPGADQKPTAAECAVRAMLYARAVRSLKRRLLPGRRRGHLRAQGLRGWKVRRATTGTQTLLSSGTRLKHHGRQAPGSLQGKSPQPDRSDAAKDCPPELAGPSPRDPSPEASGPSPKPGGLDVSEAPQTSSPCPSIDVDTKTMETAEKLAKFVAQVGPEIEQFSIENSIDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPLTLHASESADSQESPLEPMEGEGEFEDEPSQHEAELESPEVMPEEEEEEEEDEEDEEEDEEGGEEASPPGGVSRPAEGSKSEGSEGSPPADGLLSEVAEDSPAGGPALSQASSGACFPRKRISSKSLKVGMIPAPKRLCLIQEPKVHEPVRIAYDRPRGRPVSKKKKPKDFDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSCGKGIREPVSVGSASEGEGLGADGQEHKEDTFDVFRQRMMQMYRHRRASK", "length": 1113, "header": "tr|E1BE55-1|E1BE55_BOVIN Isoform 1 of SURP and G-patch domain containing 2 OS=Bos taurus OX=9913 GN=SUGP2 PE=4 SV=3 CANONICAL=E1BE55-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BE55/entry#A0A3Q1LMP4-1", "sequence": { "sequence": "MSPPRAVAAAGQRNMAARRIAQETFDAVLQEKANRYMDPSGEAVGETLQFKAQDLLRTVPRARADMFDDIHSDSRYTLGTSVTHPRDTGREGLRGDIFPGPSFRSNNPSVSEDSYFRKECGRDLEFSHPNSRDQVFGHRKLGHFRSQDWKFALHGSWEQDFAHSVSQESSWSQEYSFGPSALLGNFGSSRLIEKECLEKESHDYDGDRPGEADSVLRGSSQAQGRGRGLNLADQEGAVLGKGETQGLLTSKVGVGKLVMLRNVSTKKVPTMSRITPKTQGTNQIQKTTSSPDVTLATNPGTEVQFPTRKVPLGLDLKDVRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDVKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLTNPLDLAIALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKTESEPTRDEEKAVPSTKPEIQAQALSGLSDEVPQRADHKVVDIIDQLVARVIGGSLSPKERALLQEDPAYWFLSDDSSLEYKYYKLKLAEMQRMSQTLPGADQKPTAAECAVRAMLYARAVRSLKRRLLPGRRRGHLRAQGLRGWKVRRATTGTQTLLSSGTRLKHHGRQAPGSLQGKSPQPDRSDAAKDCPPELAGPSPRDPSPEASGPSPKPGGLDVSEAPQTSSPCPSIDVDTKTMETAEKLAKFVAQVGPEIEQFSIENSIDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPLTLHASESADSQESPLEPMEGEGEFEDEPSQHEAELESPEVMPEEEEEEEEDEEDEEEDEEGGEEASPPGGVSRPAEGSKSEGSEGSPPADGLLSEVAEDSPAGGPALSQASSGACFPRKRISSKSLKVGMIPAPKRLCLIQEPKVHEPVRIAYDRPRGRPVSKKKKPKDFDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSCGKGIREPVSVYAAGVGGRGAGSCARGDRLSGGFWP", "length": 1096, "header": "tr|A0A3Q1LMP4-1|E1BE55_BOVIN Computationally mapped isoform of SURP and G-patch domain containing 2 OS=Bos taurus OX=9913 GN=SUGP2 PE=4 SV=3 CANONICAL=E1BE55-1" }, "locus": { "chromosome": "7", "start_pos": 4209873, "end_pos": 4184237, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069207.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069207.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057993.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057993.3" } ] } }, { "isoform_ac": "A0AAA9T8H1-1", "url": "https://www.uniprot.org/uniprotkb/E1BE55/entry#A0AAA9T8H1-1", "sequence": { "sequence": "MKRKRQTEERAILSTGGFRQRNMAARRIAQETFDAVLQEKANRYMDPSGEAVGETLQFKAQDLLRTVPRARADMFDDIHSDSRYTLGTSVTHPRDTGREGLRGDIFPGPSFRSNNPSVSEDSYFRKECGRDLEFSHPNSRDQVFGHRKLGHFRSQDWKFALHGSWEQDFAHSVSQESSWSQEYSFGPSALLGNFGSSRLIEKECLEKESHDYDGDRPGEADSVLRGSSQAQGRGRGLNLADQEGAVLGKGETQGLLTSKVGVGKLVMLRNVSTKKVPTMSRITPKTQGTNQIQKTTSSPDVTLATNPGTEVQFPTRKVPLGLDLKDVRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDVKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLTNPLDLAIALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKTESEPTRDEEKAVPSTKPEIQAQALSGLSDEVPQRADHKVVDIIDQLVARVIGGSLSPKERALLQEDPAYWFLSDDSSLEYKYYKLKLAEMQRMSQTLPGADQKPTAAECAVRAMLYARAVRSLKRRLLPGRRRGHLRAQGLRGWKVRRATTGTQTLLSSGTRLKHHGRQAPGSLQGKSPQPDRSDAAKDCPPELAGPSPRDPSPEASGPSPKPGGLDVSEAPQTSSPCPSIDVDTKTMETAEKLAKFVAQVGPEIEQFSIENSIDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPLTLHASESADSQESPLEPMEGEGEFEDEPSQHEAELESPEVMPEEEEEEEEDEEDEEEDEEGGEEASPPGGVSRPAEGSKSEGSEGSPPADGLLSEVAEDSPAGGPALSQASSGACFPRKRISSKSLKVGMIPAPKRLCLIQEPKVHEPVRIAYDRPRGRPVSKKKKPKDFDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSCGKGIREPVSVGSASEGEGLGADGQEHKEDTFDVFRQRMMQMYRHRRASK", "length": 1118, "header": "tr|A0AAA9T8H1-1|A0AAA9T8H1_BOVIN Computationally mapped isoform of SURP and G-patch domain containing 2 OS=Bos taurus OX=9913 GN=SUGP2 PE=4 SV=1 CANONICAL=E1BE55-1" }, "locus": { "chromosome": "7", "start_pos": 4210538, "end_pos": 4183644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092912.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092912.1" } ] } }, { "isoform_ac": "E1BE55-1", "url": "https://www.uniprot.org/uniprotkb/E1BE55/entry#E1BE55-1", "sequence": { "sequence": "MAARRIAQETFDAVLQEKANRYMDPSGEAVGETLQFKAQDLLRTVPRARADMFDDIHSDSRYTLGTSVTHPRDTGREGLRGDIFPGPSFRSNNPSVSEDSYFRKECGRDLEFSHPNSRDQVFGHRKLGHFRSQDWKFALHGSWEQDFAHSVSQESSWSQEYSFGPSALLGNFGSSRLIEKECLEKESHDYDGDRPGEADSVLRGSSQAQGRGRGLNLADQEGAVLGKGETQGLLTSKVGVGKLVMLRNVSTKKVPTMSRITPKTQGTNQIQKTTSSPDVTLATNPGTEVQFPTRKVPLGLDLKDVRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDVKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLTNPLDLAIALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKTESEPTRDEEKAVPSTKPEIQAQALSGLSDGPMWSRVFLREDPLCVPEVPQRADHKVVDIIDQLVARVIGGSLSPKERALLQEDPAYWFLSDDSSLEYKYYKLKLAEMQRMSQTLPGADQKPTAAECAVRAMLYARAVRSLKRRLLPGRRRGHLRAQGLRGWKVRRATTGTQTLLSSGTRLKHHGRQAPGSLQGKSPQPDRSDAAKDCPPELAGPSPRDPSPEASGPSPKPGGLDVSEAPQTSSPCPSIDVDTKTMETAEKLAKFVAQVGPEIEQFSIENSIDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPLTLHASESADSQESPLEPMEGEGEFEDEPSQHEAELESPEVMPEEEEEEEEDEEDEEEDEEGGEEASPPGGVSRPAEGSKSEGSEGSPPADGLLSEVAEDSPAGGPALSQASSGACFPRKRISSKSLKVGMIPAPKRLCLIQEPKVHEPVRIAYDRPRGRPVSKKKKPKDFDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSCGKGIREPVSVGSASEGEGLGADGQEHKEDTFDVFRQRMMQMYRHRRASK", "length": 1113, "header": "tr|E1BE55-1|E1BE55_BOVIN Isoform 1 of SURP and G-patch domain containing 2 OS=Bos taurus OX=9913 GN=SUGP2 PE=4 SV=3 CANONICAL=E1BE55-1" }, "locus": { "chromosome": "7", "start_pos": 4210538, "end_pos": 4185689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017672.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017672.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017672.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017672.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A061IQC5-1", "protein_name": "SURP and G-patch domain-containing protein 2 isoform X1", "gene_name": "Sugp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAARRMAQESLDTVLQEKCKRYGDSEAVGEALQLKAQDLLRTGSRARADIYEDVHGDSRYSASGPGVYSLDLGREGLRGDMFAGPSFRSSNQSISEDSYLRKECGRDLEATHTDSRDQSFGHRKMGHFPSQDWKLALRGTWEQDLGHPVSQESSWSQEYGFGSSVLGGLASSRRLEKENPDYDLDHRGDVNSVSRGSGQVLARGRSLNMADQEGTLLGKGDTQGLLTAKGVGKLITLKNMTTKKMPVVGRITSKPQGTNQIQKTTPSPDVTLGTSPGLDEIQLAALKMPLGLDLRALGFPRRKLGFDTMEKADVFSRFGIEIIKWAGFHTIKDDLKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKGVTPLLMACNAYELSVKMKTLTSPLDLAVALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPASFPNFEDSTLFGREYIDHLKAWLMASGYPLQVKRAVPAEPREQKITPQPWAASTLSQAVPQRADHRVVDTIDQLVMRVIQGRLSPRERTLLLQDPAYWFLSDESSLEYKYYKLKLAESQRLNHSWPIVERRPTPAQCAVRAMLYAQAVRSLKRRLLPWQRRRLLRSQGPRAMKTKRAATAQHISLSSATRQRHHGRQAVGSLQVKPPPRDSSDAAQDCLPESAKPHPQPCSPGALGTSRPIEDDSEVLLASSPCPSADVDLKTMETAEKLARLVAQVGPEIEQFSIESSTDNPDLWFLHDQSSSAFKFYREKVLELCPSISFQSTGEAGDSEQSPTAHKEGEGEPEEGRPQQEATLEGPEVLPEEEEDDVEVEEDEGREETCTLRPQAGAAKCPGSEGSSPTDSIPGEGSREDQAGTPGLSQASSGSCFPRKRISSKSLKVGMIPAPKRVCLIQESKVHEPVRIAYDRPRGRPIAKKKKPKDLEFAQQKLTEKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTLSEGEGLGADGPEQKEDTFDVFRQRMMQMYRHKRASK", "length": 1065 }, "evidence": [ { "id": "E1BE55", "url": "https://omabrowser.org/oma/group/E1BE55/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A287AX25-1", "protein_name": "SURP and G-patch domain containing 2", "gene_name": "SUGP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATRRIAQETFDAVLQEKAKRYHMDPSGEAVGEALQFKAQDLLRTVPRARADMFDDIHSDSRYTLGGSIAHPRDTGREGLRSDVFPGPSFRSSNPSVSEDSYFRKECGRDLEFSHTDSRDQVFGHRKLGHFRSQDWKFALRGSWEQDFGHSVSQESSWSQEYSFGPSALLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGSSQVQGRGRGLNIVDQEGALLGKGETQGLLTPKAGVGKLVTLRSVSTKKVPTVSRITPKTQGTNQIQKTTPSSDVTLGTNPGTEDVQFPTQKIPLGLNLKDIRLPRRKMSFDLIDKSDVFSRFGIEIIKWAGFHTIKDDVKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLAVALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPARDEEKTVPPAKPEIQAKAPSGLSDEVPQRADHKVVDIIDQLVSRVVGGSLSPKERALLKEDPAYWFLSDDSSLEYKYYKLKLAEMQRMSQTMPGADQKPMAAECAVRAMLYARAVRSLKKRLLPGRRRGLLRAQGLRGWKVRKATTGTQTLLSSGTRLKHHGRQAPGSLQGKLPQPDGNAAAKDCLPDPAGPSPQDPSPEASGPSPKPAGVDVPEAPQSSSPCPSSDVDTKTMETAEKLAKFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPLNLRASESADSQESPLEPMEGEGEFEDEPPQHEAELESPEVIPEEDEEDEEEEEDEEGDEEAPTPGGASRLAGESTKSEGSEGSSPADGLLSEVAEDGSVGTPALSQASSGACFPRKRVSSKSLKVGMIPAPKRLCLIEEPKVHEPVRIAYDRPRGRPVSKKKKPKDLDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSCGKGIREPVSVGTASEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRANK", "length": 1095 }, "evidence": [ { "id": "E1BE55", "url": "https://omabrowser.org/oma/group/E1BE55/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZJH2-1", "protein_name": "SURP and G patch domain containing 2", "gene_name": "Sugp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARRMAQESLDTVLQDKSKRYGDSEAVGEALHLKAQDLLRTGSRARADVYEDIHGDSRCSVSGSAVYSLDLGREGLRGDMFVGPSFRSSNQSVGEDSYLRKECGRDLEPAHTDSRDQSFGHRNLGHFPSQDWKLALRGSWEQDLGHSVSQESSWSQEYGFGPSLLGDLASSRRMEKESRDFDLDHPGEVDSVSRSSGQVLARGRSLNMADQEGTLIGKGDTQGLLGAKGVGKLITLKSMTTKKIPVVSRITSKPQGTNQIQKAAPSPDVTVGASPVLDEIQFAALKIPLGMDLRTLSFPRRKLGFDAIDKADVFSRFGIEIIKWAGFHTIKDDLKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKGVTPLLMACNAYELSVKMKTLTSPLDLAVALETTNSLCKKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAYFPNFEDSTLFGREYIDHLKAWLMASGYPLQVKRAVPPEPREQKTTAQTWAASTLSQAVPQRADHRVVDTIDQLVMRVIQGRLSPRERTLLLQDPAYWFLSDESSLEYKYYKLKLAESQRLNHSWPIVERRPTPAQCAVRAMLYAQAVRSLKRRLLPWQRRRLLRSQGPRGLKPKKATTAQQISLSSGTRLKHHGRQASGSLRVKPPPRDSSDAAQDCLPEPAKPCAQPSSPGALGPSPQPAAGDDSEALPASSRCSSANMDAKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQSSSAFKFYREKVLELCPSISFQSTGEAGDSVQSPTAGKEGKGEPEEGRPEQEAALEGSEVLPEEEEEDEEESEEDEGGEETCTLTPQTGAAKCPGSEGSSPTESIPGEGAREDQAGTPGLSQASSGSCFPRKRISSKSLKVGMIPAPKRVCLIQESKVHEPVRIAYDRPRGRPIAKKKKPKDLEFSQQKLTDKNVGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTLSEGEGLGADGPEQKEDTFDVFRQRMMQMYRHKRASK", "length": 1068 }, "evidence": [ { "id": "E1BE55", "url": "https://omabrowser.org/oma/group/E1BE55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CH09-1", "protein_name": "SURP and G-patch domain-containing protein 2", "gene_name": "Sugp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARRMAQESLDSVLQEKSKRYGDSEAVGEALHLKAQDLLRTGSRARADVYEDIHGDSRYSASGSGVYSLDMGREGLRGDMFVGPSFRSSNQSVGEDSYLRKECGRDLEPAHTDSRDQSFGHRNLGHFPSQDWKLALRGSWEQDLGHSVSQESSWSQEYGFGPSLLGDLASSRRMEKESRDYDLDHPGEVDSVSRSSGQVLTRGRSLNIADQEGTLLGKGDTQGLLGAKGVGKLITLKSMTTKKIPVASRITSKPQGTNQIQKPTPSPDVTIGTSPVLDEIQFAALKIPLGLDLRTLGLPRRKMGFDAIDKADVFSRFGIEIIKWAGFHTIKDDLKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKSIMRLQDRLLKGVTPLLMACNAYELSVKMKTLTSPLDLAMALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAYFPNFEDSTLFGREYIDHLKAWLMASGYPLQLKRAVPPESREQKTTAQTWASSTLSQAVPQRADHRVVDTIDQLVMRVIQGRLSPRERTLLLQDPAYWFLSDESSLEYKYYKLKLAESQRLNHSWPIVERRPTPAQCAVRAMLYAQAVRSLKRRLLPWQRRRLIRSQGPRGLKAKKATTAQQTSLSSGTRQKHHGRQASGSLRVKPPPRDSSDAAQDCLSEPAKPCPQPSSPGALGPSPRPTGADDSEALPASSRCPSANMDAKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQSSSAFKFYREKVLELCPSISFQSTGEAGDSVQSPTAGKEGKGEPQEGHPEQEASLEGTEVLPEEEEEDEEESEDEGGEETSTLRPQAGAAKCPGSEGSSPTDSIPGEGSREDQASTPGLSQASSGSCFPRKRISSKSLKVGMIPAPKRVCLIQESKVHEPVRIAYDRPRGRPIAKKKKPKDMEFSQQKLTDKNVGFQMLQKMGWKEGHGLGSLGKGIREPVSVGALSEGEGLGADGPEQKEDTFDVFRQRMMQMYRHKRASK", "length": 1067 }, "evidence": [ { "id": "E1BE55", "url": "https://omabrowser.org/oma/group/E1BE55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IX01-1", "protein_name": "SURP and G-patch domain-containing protein 2", "gene_name": "SUGP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARRITQETFDAVLQEKAKRYHMDASGEAVSETLQFKAQDLLRAVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRDQVIGHRKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRALNIVDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPLGLDLKNLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPHNLHTGGGDTTGSQESPVDLMEGEAEFEDEPPPREAELESPEVMPEEEDEDDEDGGEEAPAPGGAGKSEGSTPADGLPGEAAEDDLAGAPALSQASSGTCFPRKRISSKSLKVGMIPAPKRVCLIQEPKVHEPVRIAYDRPRGRPMSKKKKPKDLDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRANK", "length": 1082 }, "evidence": [ { "id": "E1BE55", "url": "https://omabrowser.org/oma/group/E1BE55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1BE55", "url": "https://www.uniprot.org/uniprotkb/E1BE55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 838, "end_pos": 840, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BE55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE55" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 1042, "end_pos": 1088, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BE55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE55" }, { "id": "PS50128", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SURP motif", "eco_id": "ECO_0000259", "start_pos": 802, "end_pos": 845, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 248, "end_pos": 250 }, { "start_pos": 838, "end_pos": 840 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKN6-1", "uniprot_ac": "E1BKN6", "uniprot_id": "E1BKN6_BOVIN", "mass": { "chemical_mass": 233150.0, "monoisotopic_mass": 233150.0 }, "refseq": { "ac": "XP_002697790", "name": "ankyrin repeat domain-containing protein 12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697790" }, "gene_names": [ { "name": "ANKRD12", "type": "recommended", "evidence": [ { "id": "E1BKN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKN6" } ] }, { "name": "ANKRD12", "type": "synonym", "evidence": [ { "id": "XP_002697790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697790" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 12", "type": "synonym", "evidence": [ { "id": "E1BKN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKN6/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697790" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKN6", "url": "https://www.uniprot.org/uniprotkb/E1BKN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD12", "url": "https://www.uniprot.org/uniprotkb/E1BKN6", "locus": { "chromosome": "24", "start_pos": 41535783, "end_pos": 41438171, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002755", "url": "https://www.ensembl.org/id/ENSBTAG00000002755" } ] } } ], "crossref": [ { "id": "ENSBTAG00000002755", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002755", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534739", "url": "https://www.ncbi.nlm.nih.gov/gene/534739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534739", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTAVENC", "url": "https://omabrowser.org/oma/group/MTAVENC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNB3", "url": "https://www.orthodb.org/?gene=A0A3Q1LNB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKN6", "url": "https://www.orthodb.org/?gene=E1BKN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24149:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24149:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697790", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNB3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNB3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKN6", "url": "https://www.uniprot.org/uniprotkb/E1BKN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKSGFTKPVQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIDRNDVGKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTCSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTPPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQIVPSKAPLPSALDEYEFKDDDEEEINKMIDDRHILRKELRKENESEVEKSSLFAKQEKTFYPKSFKSKKQKPSRVLYSSSESSDEEILQNKKCSAPCSVPETSNSDIQTKKEYGVSNEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRVTNLTVNTALDCSDKTRDEGNFRKSFSPKDDTSLHLFHISSGKSPKHSCGLSEKQSTPLKQEHSKTCLSPGSSEMSLQPDLVRYDNIESEFLPESSSVKSCKHKEKNKHHKDFHLEFGEKSNAKIKDDDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKSRDGTKELQRSVEFDREFWKENFFKSDETEDLFLSMEHESLTLEKKSKLEKNIKDDKSTKEKHISKERNFKEEREKIKKESEKSFREEKIKDLKDDRENVLTDKETEFSSLGVSATEETIGLHSVEKEIEIEKHMKESKEKSEKRFQTKDKDIERADRKNSEKEKKIKHEHKSEKDRLDPSECVDRIKEKDKLYSHHTEKCHREGEKLKNITTIKKNDDRDKSREKMDRKHDKEKPEKERHPVESKEKHLMEKKNKPSDNSDYTKSEKSKNKEKDREVDKKDKSRDSVNISNSKHFQEERKSSITDSNKAQHEKTLSLKEKTKDEPLRTPDGKEKDKKDIDRYKERDKHKDKILSSSLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHRKHKEKIKQKEKERLRNRSCLELKVKDKEKTKHALAESKNKELTRSKSSELTDTYIKEKHCKDAVSNRSQSVDTKNTMSLGKSSFVSDNSLNRSPRSESEKPGLSSRSVSLISVASSEDSCLTTMTTPRPPVEYDSDFMLEGSDSQMSFSQSPFLPVAKSPALHDRELDSLTDLSERIKASYASRLLTSHLRASSVEDAKLVTNEGRSAAEARRCSMPSVICEHTKQFQTISEEGSQDGSAVPREICPSPKSEVSSNVPERELLSVSNIHSSFAASPTRSINSKYNSTDTNVIKGTAPLGMLMGSPVHLESSNQVGVIQSKSWEMESLNTGDFSCPNSAAPDQDSSVQGFCNPENKVLREQNIDFVSMHQTELPANTCAQDPASVLPSQQPCSSHSQSLSDAESIPRHTSLSYVTTQEPGILQQKNAIQMISSVLDTDTEPTKDMENTFVLTDVQKTDAFVPVYSESTVEEAAPNFEKASTLPVLPSEKDFNGSDGSSQPNPHYAFSKLMFKSSSGHEAEKSTSDTQDTSHEKENKLESLVLTHLNDKCDSDLCEMNVGVPKGNLSEPDNPKHCPESEKCLLSIEDEESQQSTLSSLENHPQPSAPPEMHKYGHLVKVELEESAEDDKPESQIPQRMTRNKGNTGASQSKQLLASCALLPDKDSESASPRGRIRLTEEDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYSVPLDAQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2050, "header": "tr|E1BKN6-1|E1BKN6_BOVIN Isoform 1 of Ankyrin repeat domain 12 OS=Bos taurus OX=9913 GN=ANKRD12 PE=4 SV=1 CANONICAL=E1BKN6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNB3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKN6/entry#A0A3Q1LNB3-1", "sequence": { "sequence": "MPKSGFTKPVQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIDRNDVGKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTPPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQIVPSKAPLPSALDEYEFKDDDEEEINKMIDDRHILRKELRKENESEVEKSSLFAKQEKTFYPKSFKSKKQKPSRVLYSSSESSDEEILQNKKCSAPCSVPETSNSDIQTKKEYGVSNEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRVTNLTVNTALDCSDKTRDEGNFRKSFSPKDDTSLHLFHISSGKSPKHSCGLSEKQSTPLKQEHSKTCLSPGSSEMSLQPDLVRYDNIESEFLPESSSVKSCKHKEKNKHHKDFHLEFGEKSNAKIKDDDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKSRDGTKELQRSVEFDREFWKENFFKSDETEDLFLSMEHESLTLEKKSKLEKNIKDDKSTKEKHISKERNFKEEREKIKKESEKSFREEKIKDLKDDRENVLTDKETEFSSLGVSATEETIGLHSVEKEIEIEKHMKESKEKSEKRFQTKDKDIERADRKNSEKEKKIKHEHKSEKDRLDPSECVDRIKEKDKLYSHHTEKCHREGEKLKNITTIKKNDDRDKSREKMDRKHDKEKPEKERHPVESKEKHLMEKKNKPSDNSDYTKSEKSKNKEKDREVDKKDKSRDSVNISNSKHFQEERKSSITDSNKAQHEKTLSLKEKTKDEPLRTPDGKEKDKKDIDRYKERDKHKDKILSSSLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHRKHKEKIKQKEKERLRNRSCLELKVKDKEKTKHALAESKNKELTRSKSSELTDTYIKEKHCKDAVSNRSQSVDTKNTMSLGKSSFVSDNSLNRSPRSESEKPGLSSRSVSLISVASSEDSCLTTMTTPRPPVEYDSDFMLEGSDSQMSFSQSPFLPVAKSPALHDRELDSLTDLSERIKASYASRLLTSHLRASSVEDAKLVTNEGRSAAEARRCSMPSVICEHTKQFQTISEEGSQDGSAVPREICPSPKSEVSSNVPERELLSVSNIHSSFAASPTRSINSKYNSTDTNVIKGTAPLGMLMGSPVHLESSNQVGVIQSKSWEMESLNTGDFSCPNSAAPDQDSSVQGFCNPENKVLREQNIDFVSMHQTELPANTCAQDPASVLPSQQPCSSHSQSLSDAESIPRHTSLSYVTTQEPGILQQKNAIQMISSVLDTDTEPTKDMENTFVLTDVQKTDAFVPVYSESTVEEAAPNFEKASTLPVLPSEKDFNGSDGSSQPNPHYAFSKLMFKSSSGHEAEKSTSDTQDTSHEKENKLESLVLTHLNDKCDSDLCEMNVGVPKGNLSEPDNPKHCPESEKCLLSIEDEESQQSTLSSLENHPQPSAPPEMHKYGHLVKVELEESAEDDKPESQIPQRMTRNKGNTGASQSKQLLASCALLPDKDSESASPRGRIRLTEEDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYSVPLDAQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2027, "header": "tr|A0A3Q1LNB3-1|E1BKN6_BOVIN Computationally mapped isoform of Ankyrin repeat domain 12 OS=Bos taurus OX=9913 GN=ANKRD12 PE=4 SV=1 CANONICAL=E1BKN6-1" }, "locus": { "chromosome": "24", "start_pos": 41534779, "end_pos": 41472891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084265.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084265.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058290.1" } ] } }, { "isoform_ac": "E1BKN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKN6/entry#E1BKN6-1", "sequence": { "sequence": "MPKSGFTKPVQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIDRNDVGKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTCSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTPPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQIVPSKAPLPSALDEYEFKDDDEEEINKMIDDRHILRKELRKENESEVEKSSLFAKQEKTFYPKSFKSKKQKPSRVLYSSSESSDEEILQNKKCSAPCSVPETSNSDIQTKKEYGVSNEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRVTNLTVNTALDCSDKTRDEGNFRKSFSPKDDTSLHLFHISSGKSPKHSCGLSEKQSTPLKQEHSKTCLSPGSSEMSLQPDLVRYDNIESEFLPESSSVKSCKHKEKNKHHKDFHLEFGEKSNAKIKDDDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKSRDGTKELQRSVEFDREFWKENFFKSDETEDLFLSMEHESLTLEKKSKLEKNIKDDKSTKEKHISKERNFKEEREKIKKESEKSFREEKIKDLKDDRENVLTDKETEFSSLGVSATEETIGLHSVEKEIEIEKHMKESKEKSEKRFQTKDKDIERADRKNSEKEKKIKHEHKSEKDRLDPSECVDRIKEKDKLYSHHTEKCHREGEKLKNITTIKKNDDRDKSREKMDRKHDKEKPEKERHPVESKEKHLMEKKNKPSDNSDYTKSEKSKNKEKDREVDKKDKSRDSVNISNSKHFQEERKSSITDSNKAQHEKTLSLKEKTKDEPLRTPDGKEKDKKDIDRYKERDKHKDKILSSSLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHRKHKEKIKQKEKERLRNRSCLELKVKDKEKTKHALAESKNKELTRSKSSELTDTYIKEKHCKDAVSNRSQSVDTKNTMSLGKSSFVSDNSLNRSPRSESEKPGLSSRSVSLISVASSEDSCLTTMTTPRPPVEYDSDFMLEGSDSQMSFSQSPFLPVAKSPALHDRELDSLTDLSERIKASYASRLLTSHLRASSVEDAKLVTNEGRSAAEARRCSMPSVICEHTKQFQTISEEGSQDGSAVPREICPSPKSEVSSNVPERELLSVSNIHSSFAASPTRSINSKYNSTDTNVIKGTAPLGMLMGSPVHLESSNQVGVIQSKSWEMESLNTGDFSCPNSAAPDQDSSVQGFCNPENKVLREQNIDFVSMHQTELPANTCAQDPASVLPSQQPCSSHSQSLSDAESIPRHTSLSYVTTQEPGILQQKNAIQMISSVLDTDTEPTKDMENTFVLTDVQKTDAFVPVYSESTVEEAAPNFEKASTLPVLPSEKDFNGSDGSSQPNPHYAFSKLMFKSSSGHEAEKSTSDTQDTSHEKENKLESLVLTHLNDKCDSDLCEMNVGVPKGNLSEPDNPKHCPESEKCLLSIEDEESQQSTLSSLENHPQPSAPPEMHKYGHLVKVELEESAEDDKPESQIPQRMTRNKGNTGASQSKQLLASCALLPDKDSESASPRGRIRLTEEDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYSVPLDAQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2050, "header": "tr|E1BKN6-1|E1BKN6_BOVIN Isoform 1 of Ankyrin repeat domain 12 OS=Bos taurus OX=9913 GN=ANKRD12 PE=4 SV=1 CANONICAL=E1BKN6-1" }, "locus": { "chromosome": "24", "start_pos": 41534779, "end_pos": 41472891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003572.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003572.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003572.3", "url": "https://www.ensembl.org/id/ENSBTAP00000003572.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534739", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534739", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XAC9-1", "protein_name": "Ankyrin repeat domain 12", "gene_name": "ANKRD12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKSGSTKTAQIENSDSDSTMVEKPAARKSKDKIASYSKSPKVDRSDVGKEMKEKSSMKRKLPFTISPSRNEDRNSDTEKEGPEKKKVKKDAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSNLNHPLQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKVLIAAGADVNTQGLDDDTPLHDSASSGHRNIVKLLLRHGGNPFQANKHGERPVDVAETEELEMLLKREVPISDDEDSCSDSEEAPSVNPSSVEGNVDSEVEKDSVANGSKQIVHSKAPHPPALDEYEFKDDDEDEMKKMIDDRHILRKDVRKEDETEVEKNSLFAKQDKVSYSKSLKNKKQKPSRVLYSSSESSDEEIVQDKKIVSPCSVSETSSSDVRAKKECVVTNEHKQKGKVKKKVKNQSKNKENQELKQEKENARVTNIAASGLDSLDKTRDEETFKKSFSQKDDSSLQLFHIAAGKSPKHPCGLSEKQATALKQENTKTCLSPGGSEITLQPELVRCDHSVDSEYLVESSSGKSCKHKEKSKHHQKDFQLEFGEKSSPKIKDEDNSSTFENSEYTLRKIDKEGKALKKHKLKHKEREKDKDKKEQDGEKEKHKHNIKESQRSIEFDREFWKENFFKSDDSEDTLLNTEHETLPSDRKSKLEKAVAKEDRLAKERQFHKERNAREEREKNKKENEKFLKDEKMKDSKEEKETILADKEMEMFCLSVKDEVISMHLIEKEADTEKHEKNLKENKEKRTSAKEKDVEKAERKNGEKEKKIKHECKTEKAEVNENMEKVKEKTNFQQAERCHKENDKIKSTGALKKLDEKEKNKEKMEKKHDKEKVDKDRHLADSKEKHCIERKVKQSEKESEYTKSEKNRTKDKEKEPERRDKSKDKETSTVVNSKHVQEERRCNIADSNKSMHDKLTSLKEKQKDDFLKTPDGREKDKKDKDIDRYKERDKHKQHQSSLLKLKLEHEKLKPKTSPAPKDARPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHRKHKEKIKQKEKERLRNRTCLELSKIKEKQRQSLPEVKNKELTRSKSSELPDFCMKEKQQKEATSSRSQSVDTRNVNVIKSLLVLDNANKSPKSEGEKMGLSSKSVSIISVASSEDSCHTTVTTPRPAMECDSDFVLEGADSQMSFSQSPFLPTAKSPALLERETDGVAELSDRMKPSFANRLPPAYIRSASFEDFKLVLNECRPVVEVRRCSMPASVSEHSKPPRISEENNQNAQMSVQTYPSTSPKPELPCSMVERDIQSSFSGLRSSPTRAVSNKQVTMGTNTIKNTAQMSPSEECNIHLEPCSQSGVTQQTKPWDVPFDRLNSINNECSSSGYDVSEQDTNNFVAMHNSETRTIKEQKVAEYLPQPAEIKGNSSSQESASFLPSQSPCSLPIQPLPEGSKHISSPGISNQDSLPVQQNLVQTVSSAFNTDASSTRETENVFIPSNIKKADAPHAIYSEGSAKDISEICERVNDLPVVVLERDIPESDGTSQLNVNSYVFNKLVCKNTQIEVDGNTVDTSNFRNEKDQQENLISVHVVNSKADTDLCDLRSAMSQGIMNNSSNKKPCTADGEDVLTDEAPQYSLSNSENNSQEIIQEEVHKYSQIVKLEEIAEDQKMEQQEVPQRITRNRANVLANQGKQNPVVCMQTLEKESELLASMKGRIRLTEDDDGQVHHPRKRKVSRVPQPVQVNPSLLQAKEKTQQSLAAVVDSLKLEEIQPYCSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFKQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDAQADDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2015 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B8JLP7-1", "protein_name": "Ankyrin repeat domain-containing protein 12", "gene_name": "ankrd12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKPGSDRDEAMVEKTAGKKSKEKISPFAKTPKLDRSELLGKEGKSKSSMKRKLSFTVSPSRNEERDSDADDSDPGQSSDAWGERLLPPCRIYADKDGPDKKKVKKESGGKKSTPVNILFGYPLSERKQMALVMQMTARDNSPDTTPNHPSQSPAVQKKIASSSTSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIGLGADVNVKDFAGWTPLHEACNLGYYDVAKVLIGAGAEVNTQGLDDDTPLHDASSSGHKDIVKLLLRHGGNAFQANKRGERPVDVADSQELEQLLKGEIPLSEPEDSSSESEDPSSVNPSSVDENLEFSDAEKDSDCKSTTVKASSSMSGLDEYEFKDEEEEEDLSKSLNERHLFRRELRQKEKEEKDRNHYASKQGSKSDQSMLACKSKKTKASRVYCSSDSSSDEAEVQTERRSSPTRSVSVDGHKTDSRSKKESLTLTPVEQKEKGKQKKKNKSQSKNKENQEVREEGKENSKSLLFSSPTVSDNSDKGVREEDSFKMSFSAKDDTSVHLFHLSVVKSPKLNHSQTDKQATPLKQENAKTCVSIADGSCPGDGIKYNHYTDSDYCTEDSSSKSCKHKEKSKHHHKEPNLEGDDGSSSPFKDSSLSNSIDSSEGAFRKTDKDGKVVKKHKLKHKEKEKEKYRKEYEAERNRHRQKEPRKDGHRNLEFDREFWKENFFKSDENEEPVGKGEIPAGGSPVKSSDSSPVKEEKGASKDKHSTSSSNKDRRPKEERDKTIKKEKKEIPLKEERGKEDETDERTDGTFSVRIPDGSQHLSEEVDEKPATCNSADQEQLESPEKNSREKTDKRPPTKDRESEKSDKRHSDKDKKVKSEHLADKPELHNSTDRWKEKEKLTNVSYSPNDKSHKEGEKLKPMTPVKKHEENKKNKDKLDKKAEKEHASGDHRDKDKTTSEKKGKAPEKTADHGKSDRSKDKERDKDSDKRKKDKSTTPSSSSYSNLKSLLEEKKGYVCENNKVVSSKSKEEVTKPSEKDRDRRERDRESERHRDRERDRHKEKDKDRSQFNRDGKINKPKPSEVDSKSKVTPILKDTRPKEKRLVNDDLMKTSFERMLSLKDQEIEQWHKKHLEKIKQKERERLKQRPGIDPAKQQKNKEKIKSSSTSTEPCLTKELTRSKSSEAPDGQREKILKDATSVRTLSLDAKTLGKNGPIIENNLSRSPRPESEKSGLMSRSISMISVASSEDSCQATILTPRPTDQYDSDMNVEALDSQPPLLQSSLVAQSSRSPSVHDKDISSLPESSALCNRTPLASRHASPCLRAILDEEAKVPTTETKPTEESPVISIASQPTSEQSQVHLTEISVPPVQETRSSQSLTNSFPENEILSSNEAEVVSSTCQVQPSQASAKDSVTQANSVFPSHLEEQNKFCTTSSQIEHASLGQLDVPGAEGVKKEASLAVASLQSSHTSTSSSDSNAHLPSSSQHCEISSASSGEQTMTTDSSLRTEQRDKPLVASEDKIGEHVTKTDCASTPSPSTASCRSSSEESTKPLLKATSVQEDTEKGNEQVQEESISRFSNDPLVAVDAQPEKEEQGLHLASVTNVSCCASPERIPEEPMEVPEEVSDKSRITEIDEAKVLSSEEGAVTSSESKADSETPDPFSLDEKPLKSDILANVEQAQSSAPIHPDHQAEPTSGETSGSSSPISVMDRDSDISGARAKVRLLEEEADIQATHPRKRKMPRASPLAQANLTAQQVREKTQQSLAAIVDALKLEEIQPYQTERANPYYEYLHIRKKIEEKRKVLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKLCIPTITPPPSLPEPLKEMFKQQEMVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNMPQEVQGDDGKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSTSIFEIPEFYIPLVEVNDDFDLTPI", "length": 1987 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZCH1-1", "protein_name": "Ankyrin repeat domain 12", "gene_name": "Ankrd12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKSGFTKPVQSENSDSDSSMVERPYGRKSKDKIASYSKTSKIDRGDMGKEIREKSSMKRKLPFTLSPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTRKEAGTKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPSHPSQATPAQKKTPSSSSRQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGADVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSGDDESYTDSEEAQSVNPSSVDENIDSETEKDSFVCGSQSLPSKAPLPSALDEYEFKDDDGEEISKMIDGRHILRREQRKENESEAERSGLFAKQEKPFYSKSFKTKKQKPSRVLYSSTESSDEEVLQNRKISTACSVAETSHSDVQAKREYEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIANLAVNTALDCSERNREDGAFRRSFSPKDDASLHLLHMPTGKSPKHPCGLSEKQATPLKQDHMKTCISPGSSETSLQPELSRYENAEPEFLPESSNVKPYKHKEKNKHQKDFHLEFGEKSNAKIKDEDHSAAFENSDCTLKKMDKEGKTLKKHKLKHKERDKEKHRKEAEGEKEKYKSRDNAKEPQRSIEFDREFWKENFFKSDETEDLFLNMEHESLTEKKSKVEKTVKDDRLAKDKHASKERNCKEEREKTKRENEKSLKEERLKDPKEEKDGVSAEKEAEGSSMAVSANQETSGPHSSEREVDIEKQERHSKEREKSDRRFQTKEKELDRTERKVSEKEKKLKHEHKSEREKLDFSDCTDRVKEKDRLYSPQTERCHKEGEKMRNTVRKAEDRERAREKTDRKHDREKPERERCLAESKEKYLEKRKQSDNSEYSKSEKVRNRDRDREGEKKEKLRDKESVNVANLRHLQEERKSSTGEGSSKTQHEKALSLKERVRDEPLKIPDGKEKDKKDIDRYKERDKRKEKAQLSTLIRLKSETEKLKPKLSPASKDARPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRSCLELKVKDKEKTKHTPSESKNKELTRSRSSELTDVYNKEKQSKDVGSNRSQSVDNKSVLSLGKLPYVSENSSSRSPRSEGEKLGLSSRSVSMLSVASSEDSCHTVTTPRPLVEYDSDFMLEGSESQLSFSQSPFLPNAKSPALYERELESLAELPERLKPPYANRLPVCHLRSSSVEDVKLITNEVRPAVEIRRCSMPSVICEPIKHFQVSEDSSQGNLAVPRETSLSPRPEVSLVPERGLSHVSDLHPRCTDSPVRSVDSSSVSSDVHVIKSAALVGTLIDTSMHLETSNQVGVIQSKSWETPVDKLESLSTNDFICPDSSTSDQDSSAQSFYHSENKMLREQNADCLPVHQTELPGNSCAQDPASFTLSSPQPCSFTNQSLSDAESLPKPVSLSYGASQEPGVLQQRSAAHMISSVLESDNNFTKEVESSFVLADIQKTNSFVPAYSESTVQETLPNFEKANTLLVLPSEKDFSGSDAASQLNTHYAFSKLTYKSSSSHEIEKGPDDTQVISHEKENKLQSLVLTPLSKCDSDLYEVNAGMPKGNLNEQDNPKHGPDSEKDSLSTEDEESQQSTLSSVENHSQQSAQPEIQKYDQMVKGELEENAEDDKTENQTPQRMTRNKASALVSQSKQVLAGCTLLPEKDNDSSPRGRIRLTEEDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAALVDSLKLDEIEPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2047 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HZ26-1", "protein_name": "Ankyrin repeat domain-containing protein 12 isoform X1", "gene_name": "Ankrd12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPRSGFPKPVQSENSDSDSNMVERPYGRKSKDKIASYSKTSKIDRGDIGKEMKEKPSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGSKKSTPVSILFGYPLSERKQMALVMQMTARDNSPDSTPSHPSQATPAQKKTPSSSSRQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSGDDESYTDSEEAHSVNPSSVDENIDSEPEKDPFICESKVLPSKAPLPSALDEYEFKDDDEEEIGRMIDDRHILRKEQRKESELEAEKSGLFAKQEKAFYCKSFKAKKQKPSRVLYSSTDSSDEDLLQGSKRASTTCSVPETSSADTQARREYEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTALDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHACGLSEKQSTPLKQEHTKACISPGSSEMSLQPDLARYDTTEPEFLPENTNLKSYKHKEKSKHQKDFHLEFGEKSNAKMKDEDHNPTFENSECTLKKMDKEGKTLKKHKLKHKEREKEKHRKEADSEKEKYRNKGNPEELQRGIEFDREFWKENFFKSDETEDLFLNMEHESLTEKKSKLEKNMKDDKSTKEKHVSKERSFKEEREKTKKESEKSLREEKLKEDRDSMSTEKDVECGSVGIALNQESVGPHSAEKEMDIEKQEKHTREREKSDRRFQTKEKEVEKTERKFSEKEKKMRHEHKSEKEKWDFSENVDRIKEKDKLWSQQTERCQKEGEKTKNTVKKTDDRERNREKVDRKHDKERPEKERCLAESKEKHLEKKKCDNSEYTKSEKARNKDREGEKKEKFRDKESINITNSRHLQEEKRSSIGDSSSKIQHEKTVSLKEKARDEPLKTPDGKEKDKKDIDRYKERDKRKDKIQLNTLIKLKSETDKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRTCLELKVKDKDKTKHTPTESKSKEFARSRSSELTDAYNKEKQSKDAGSNRSQCVDSKNVLNLGKSPFIPENSSNRSPRSESERLGLSSRSVSMISVASSEDSCHTVTTPRPPVEYDSDFMLEGSESQLSFSQSPFLPNAKSPALYERELESLADLPERLKAPCTNRVPVCHLRSSSVEDVKVIPSEARPAVEIRRCSMPSVICEPTKHFQIPEESAQGSLAVPRETCPSPKPEVSSAVPERGLPHVSEFHPNLAGSPTRSVNSRYISSDTNVIKSVSLVGTLMDSPMNLEPSNQVGVIQNKSWEMPAEKLESLSTNDLICPDPSTSDQDSSAQSFCHSENKTLREQNTDCLSSPQTEMPGKSCAQDAASLLSSLQPCSFSNQAHSDAESASKAVSLSCGASQEPGVLQERNAGHVISSVLDSDNNFTKEMENAFVLADIQKTNSFVPVYSESTVQETLASFEKASTLLVLPSGKDFSGSDGASQMSTQYTFSKLTYKSSSSHQVEKSIDDTQVTSHEKEKRLQGLVLTQLSKCDSDLYGMDAGMPKGSLSDQDPAKHSPGSEKYLLPIEDEESQQSPLSSVESHSQPSAQPELHKYDQLTKGDLEESAEDDKTENQHPQRLTRNKVSPVVSQSKQILAGCTLLPEKDSDSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2042 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G5E893-1", "protein_name": "Ankyrin repeat domain 12", "gene_name": "Ankrd12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKSGFTKPVQSENSDSDSSMVERPYGRKSKDKIASYSKTSKIDRGDMGKEMREKPSMKRKLPFTVSPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGTKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPSHPSQATPAQKKTPSSSSRQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSGDDESYTDSEEAQSVNPSSVDENIDSETEKDSFVCGSKILPSKAPLPSALDEYEFKDDDEEEISKMIDDRHILRKEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDEEGLQNRKISTACSVAESSHPDMQAKKEYEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIKDEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECCSVGVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRKHDREKPERERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERKSSTGDSSGKTQHEKALSLKERARDEPLKTPDGKEKDKKDIDRYKERDKRKDKAQLNTLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHRKHKEKIKQKEKERLRNRTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVYSKEKQSKDVGSNRSQSVDNRNVLNLGKPSYISESGSNRSPRSEGERLGLSSRSVSMLSVASSEDSCHTVTTPRPLVEYDSDFMLEGSESQLSFSQSPFLPNAKSPALYERELEGLTELPDRLKPPYTNRLPVCHLRSSSVEDVKLITNEVRPAVEIRRCSMPSVICEPIKHFQVSEESSQGNLAVPRETCLSPKPEVSSAVPERGLSHVSDLHPNCTGSPTRSANSSYISSDVNVIKSATLVGTLIDSSMHLEPSNQVGVIPSKSWETPVDKLESLSTNDFICPDSNISDQDSSAQSFYNSENKMLREQNTDCLPPHQPELPGNSCAQDPASFLSSPQPCSFSNQPLAGADSVPKPVSLSYVVSQEPGVLQQKSAAQMASSVLDSDNNFPEDVENTFVLADIQKTNSFLPAYSESTVQEALPSFEKANTLLVLPSEKDFNGSDTAQPNTHYAFSKLTYKSSNSQEIEKGPDDTQIISHEKENKLQSLVLTQLSKCDSDLYEMNAGLPKGNLNEQDNPKHGLDSEKYSLSTEDEESQQSTLSSVENHSQQSAQPEMHKYDQLSKVELEENAEDDKTENQTPQRVTRNKASTVVNPSKPMLAGCALVAEKDNESSPRGRIRLTEEDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIEPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSLSIYEIQEFYVPLVDVNDDFELTPI", "length": 2041 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6UB98-1", "protein_name": "Ankyrin repeat domain-containing protein 12", "gene_name": "ANKRD12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI", "length": 2062 }, "evidence": [ { "id": "E1BKN6", "url": "https://omabrowser.org/oma/group/E1BKN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BKN6", "url": "https://www.uniprot.org/uniprotkb/E1BKN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1103, "end_pos": 1105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1153, "end_pos": 1155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1178, "end_pos": 1180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1372, "end_pos": 1374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1578, "end_pos": 1580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1650, "end_pos": 1652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1859, "end_pos": 1861, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1933, "end_pos": 1935, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 886, "end_pos": 888, "annotation": "n_glycosylation_sequon" }, { "start_pos": 965, "end_pos": 967, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1103, "end_pos": 1105 }, { "start_pos": 1153, "end_pos": 1155 }, { "start_pos": 1178, "end_pos": 1180 }, { "start_pos": 1372, "end_pos": 1374 }, { "start_pos": 1578, "end_pos": 1580 }, { "start_pos": 1650, "end_pos": 1652 }, { "start_pos": 1859, "end_pos": 1861 }, { "start_pos": 1933, "end_pos": 1935 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 501, "end_pos": 503 }, { "start_pos": 886, "end_pos": 888 }, { "start_pos": 965, "end_pos": 967 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFY5-1", "uniprot_ac": "E1BFY5", "uniprot_id": "E1BFY5_BOVIN", "mass": { "chemical_mass": 128560.0, "monoisotopic_mass": 128560.0 }, "refseq": { "ac": "XP_024857376", "name": "rho GTPase-activating protein 39 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857376" }, "gene_names": [ { "name": "ARHGAP39", "type": "recommended", "evidence": [ { "id": "E1BFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ] }, { "name": "ARHGAP39", "type": "synonym", "evidence": [ { "id": "XP_024857376", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857376" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 39", "type": "recommended", "evidence": [ { "id": "E1BFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY5/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 39 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024857376", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857376" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP39", "url": "https://www.uniprot.org/uniprotkb/E1BFY5", "locus": { "chromosome": "14", "start_pos": 415367, "end_pos": 359204, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007186", "url": "https://www.ensembl.org/id/ENSBTAG00000007186" } ] } } ], "crossref": [ { "id": "E1BFY5", "url": "https://alphafold.ebi.ac.uk/entry/E1BFY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007186", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007186", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04389", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04389", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532363", "url": "https://www.ncbi.nlm.nih.gov/gene/532363", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNB6", "url": "https://www.orthodb.org/?gene=A0A3Q1LNB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BFY5", "url": "https://www.orthodb.org/?gene=E1BFY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45876:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45876:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9035034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9035034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024857376", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857376", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNB6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNB6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFY5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARPARSLRGDAFLTDAGGRPDDRLTAVRLAPEEEAAMSQAQDYECESQHAGLLESRVSGSSTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQDCDIIPLAKLQTLKQNTESPRASAENSPGRGSSVSRDGSTSSSLEPELDSGDRAPEPVGRASRQATPGMVKDESSSSSPSGVLLEKDYEVYRDYSVDGHLLHCRTSSLRWNSGTKERMLIKVADREPSFLSPQGNGYALDSQPGGRSRRPSGGQHSPSLQTFTPDADSPVFFPERRPSPFPKRAELGSCSPLLAQPRRPAGDSQPSSPRYAYEPPLYEEPPVEYQAPLYDEPPMDVQFEAGSPRRSPGRKPPKAASASPYQQLVLTRQKCPERYLSLEYSPAGKEYVRQLVYVEQASSSPKLRAGPRHKYTPHPGGGSLSLQPSPCLLRDQRLGATSSLGVVSGDYSSMEGPELRPAPPPTPLPQAQDDAMSWSSQQDTMSSTGYSPSTRKRKSRNPSVCHAPSAPPAEGPGDCDPLSQQPLTDERPLCGPGLTPIKRTEGEAGDGEGHRGPAEPFLAQARLAWEAQQAHLHMKQRGSWDSQQDGSGYESDGAVPLPMPGPVVRAFSEDEALAQQESKHWQRGALDRLAFPQVLLEKSVSVQTSLASPEPYLHPSQSEDLGTCAQFESSRQARSVMPSASCVFPTFTLRKPSSETDIENWASKHFNTHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACEVFKLIQMYMGDRRAKADPLHVALEIATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHMKALLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRLVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCRSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL", "length": 1151, "header": "tr|E1BFY5-1|E1BFY5_BOVIN Isoform 1 of Rho GTPase-activating protein 39 OS=Bos taurus OX=9913 GN=ARHGAP39 PE=4 SV=2 CANONICAL=E1BFY5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNB6-1", "url": "https://www.uniprot.org/uniprotkb/E1BFY5/entry#A0A3Q1LNB6-1", "sequence": { "sequence": "MAARPARSLRGDAFLTDAGGRPDDRLTAVRLAPEEEAAMSQAQDYECESQHAGLLESRVSGSSTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQDCDIIPLAKLQTLKQNTESPRASAENSPGRGSSVSRDGSTSSSLEPELDSGDRAPEPVGRASRQATPGMVKDESSSSSPSGVLLEKDYEVYRDYSVDGHLLHCRTSSLRWNSGTKERMLIKVADREPSFLSPQGNGYALDSQPGGRSRRPSGGQHSPSLQTFTPDADSPVFFPERRPSPFPKRAELGSCSPLLAQPRRPAGDSQPSSPRYAYEPPLYEEPPVEYQAPLYDEPPMDVQFEAGSPRRSPGRKPPKAASASPYQQLVLTRQKCPERYLSLEYSPAGKEYVRQLVYVEQASSSPKLRAGPRHKYTPHPGGGSLSLQPSPCLLRDQRLGATSSLGVVSGDYSSMEGPELRPAPPPTPLPQAQDDAMSWSSQQDTMSSTGYSPSTRKRKSRNPSVCHAPSAPPAEGPGDCDPLSQQPLTDERPLCGPGLTPIKRTEGEAGDGEGHRGPAEPFLAQARLAWEAQQAHLHMKQRGSWDSQQDGSGYESDGAVPLPMPGPVVRAFSEDEALAQQESKHWQRGALDRLAFPQVLLEKSVSVQTSLASPEPYLHPSQSEDLGTCAQFESSRQARSVMPSASCVFPTFTLRKPSSETDIENWASKHFNTHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACEVFKLIQMYMGDRRAKADPLHVALEIATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHMKALLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPGVRAACQCGHHQDGRQQPGHGDGAQLPALPLR", "length": 1062, "header": "tr|A0A3Q1LNB6-1|E1BFY5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 39 OS=Bos taurus OX=9913 GN=ARHGAP39 PE=4 SV=2 CANONICAL=E1BFY5-1" }, "locus": { "chromosome": "14", "start_pos": 414685, "end_pos": 359403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070608.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070608.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058454.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058454.2" } ] } }, { "isoform_ac": "E1BFY5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFY5/entry#E1BFY5-1", "sequence": { "sequence": "MAARPARSLRGDAFLTDAGGRPDDRLTAVRLAPEEEAAMSQAQDYECESQHAGLLESRVSGSSTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQDCDIIPLAKLQTLKQNTESPRASAENSPGRGSSVSRDGSTSSSLEPELDSGDRAPEPVGRASRQATPGMVKDESSSSSPSGVLLEKDYEVYRDYSVDGHLLHCRTSSLRWNSGTKERMLIKVADREPSFLSPQGNGYALDSQPGGRSRRPSGGQHSPSLQTFTPDADSPVFFPERRPSPFPKRAELGSCSPLLAQPRRPAGDSQPSSPRYAYEPPLYEEPPVEYQAPLYDEPPMDVQFEAGSPRRSPGRKPPKAASASPYQQLVLTRQKCPERYLSLEYSPAGKEYVRQLVYVEQASSSPKLRAGPRHKYTPHPGGGSLSLQPSPCLLRDQRLGATSSLGVVSGDYSSMEGPELRPAPPPTPLPQAQDDAMSWSSQQDTMSSTGYSPSTRKRKSRNPSVCHAPSAPPAEGPGDCDPLSQQPLTDERPLCGPGLTPIKRTEGEAGDGEGHRGPAEPFLAQARLAWEAQQAHLHMKQRGSWDSQQDGSGYESDGAVPLPMPGPVVRAFSEDEALAQQESKHWQRGALDRLAFPQVLLEKSVSVQTSLASPEPYLHPSQSEDLGTCAQFESSRQARSVMPSASCVFPTFTLRKPSSETDIENWASKHFNTHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACEVFKLIQMYMGDRRAKADPLHVALEIATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHMKALLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRLVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCRSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL", "length": 1151, "header": "tr|E1BFY5-1|E1BFY5_BOVIN Isoform 1 of Rho GTPase-activating protein 39 OS=Bos taurus OX=9913 GN=ARHGAP39 PE=4 SV=2 CANONICAL=E1BFY5-1" }, "locus": { "chromosome": "14", "start_pos": 414782, "end_pos": 359403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037363.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037363.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037196.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037196.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 200, "start_aa": "Thr", "end_pos": 200, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr200", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 495, "start_aa": "Thr", "end_pos": 495, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr495", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-9035034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9035034", "resource": "Reactome", "description": "RHOF GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BFY5", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1151, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFY5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" }, { "id": "PS51016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MyTH4", "eco_id": "ECO_0000259", "start_pos": 759, "end_pos": 911, "start_aa": "Trp", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 958, "end_pos": 1146, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY5" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 135, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 200, 495 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 122, "end_pos": 124 }, { "start_pos": 874, "end_pos": 876 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFC5-1", "uniprot_ac": "E1BFC5", "uniprot_id": "E1BFC5_BOVIN", "mass": { "chemical_mass": 59450.0, "monoisotopic_mass": 59450.0 }, "refseq": { "ac": "XP_003587435", "name": "protein FAM222B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587435" }, "gene_names": [ { "name": "FAM222B", "type": "recommended", "evidence": [ { "id": "E1BFC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC5" } ] }, { "name": "FAM222B", "type": "synonym", "evidence": [ { "id": "XP_003587435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587435" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 222 member B", "type": "synonym", "evidence": [ { "id": "E1BFC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC5/entry#names_and_taxonomy" } ] }, { "name": "protein FAM222B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003587435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587435" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFC5", "url": "https://www.uniprot.org/uniprotkb/E1BFC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM222B", "url": "https://www.uniprot.org/uniprotkb/E1BFC5", "locus": { "chromosome": "19", "start_pos": 20173363, "end_pos": 20228801, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047717", "url": "https://www.ensembl.org/id/ENSBTAG00000047717" } ] } } ], "crossref": [ { "id": "E1BFC5", "url": "https://alphafold.ebi.ac.uk/entry/E1BFC5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506074", "url": "https://www.ncbi.nlm.nih.gov/gene/506074", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506074", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506074", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTHYTNG", "url": "https://omabrowser.org/oma/group/MTHYTNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFC5", "url": "https://www.orthodb.org/?gene=E1BFC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16070:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16070:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587435", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587435", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP33", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP33-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFC5", "url": "https://www.uniprot.org/uniprotkb/E1BFC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFC5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATRAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALSHQGLQHPPTPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGVSTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAASAALPPAGPVNLPAGLSRAPTGYPSDLKPVAWNQHQLAHLQQMCGEAGGTPAPGLTGKHAAGRELAGPGLVGKTPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAVPFHGGQPTGAPLDCAAVAAGAHFRAGTGGGPVASQNSLIQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTDSRSLHVQHPGYR", "length": 563, "header": "tr|E1BFC5-1|E1BFC5_BOVIN Isoform 1 of Family with sequence similarity 222 member B OS=Bos taurus OX=9913 GN=FAM222B PE=4 SV=1 CANONICAL=E1BFC5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP33-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC5/entry#A0A3Q1LP33-1", "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATRAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQSLQQPQGLGHPQPMAQTQGLVHPQALSHQGLQHPPTPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGVSTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAASAALPPAGPVNLPAGLSRAPTGYPSDLKPVAWNQHQLAHLQQMCGEAGGTPAPGLTGKHAAGRELAGPGLVGKTPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAVPFHGGQPTGAPLDCAAVAAGAHFRAGTGGGPVASQNSLIQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTDSRSLHVQHPGYR", "length": 523, "header": "tr|A0A3Q1LP33-1|E1BFC5_BOVIN Computationally mapped isoform of Family with sequence similarity 222 member B OS=Bos taurus OX=9913 GN=FAM222B PE=4 SV=1 CANONICAL=E1BFC5-1" }, "locus": { "chromosome": "19", "start_pos": 20184358, "end_pos": 20175922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075811.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075811.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061818.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061818.2" } ] } }, { "isoform_ac": "A0AAA9TD02-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC5/entry#A0AAA9TD02-1", "sequence": { "sequence": "MRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATRAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALSHQGLQHPPTPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGVSTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAASAALPPAGPVNLPAGLSRAPTGYPSDLKPVAWNQHQLAHLQQMCGEAGGTPAPGLTGKHAAGRELAGPGLVGKTPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAVPFHGGQPTGAPLDCAAVAAGAHFRAGTGGGPVASQNSLIQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTDSRSLHVQHPGYR", "length": 530, "header": "tr|A0AAA9TD02-1|A0AAA9TD02_BOVIN Computationally mapped isoform of Family with sequence similarity 222 member B OS=Bos taurus OX=9913 GN=FAM222B PE=4 SV=1 CANONICAL=E1BFC5-1" }, "locus": { "chromosome": "19", "start_pos": 20177511, "end_pos": 20175922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089776.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089776.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094624.1" } ] } }, { "isoform_ac": "E1BFC5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC5/entry#E1BFC5-1", "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATRAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALSHQGLQHPPTPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGVSTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAASAALPPAGPVNLPAGLSRAPTGYPSDLKPVAWNQHQLAHLQQMCGEAGGTPAPGLTGKHAAGRELAGPGLVGKTPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAVPFHGGQPTGAPLDCAAVAAGAHFRAGTGGGPVASQNSLIQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTDSRSLHVQHPGYR", "length": 563, "header": "tr|E1BFC5-1|E1BFC5_BOVIN Isoform 1 of Family with sequence similarity 222 member B OS=Bos taurus OX=9913 GN=FAM222B PE=4 SV=1 CANONICAL=E1BFC5-1" }, "locus": { "chromosome": "19", "start_pos": 20184358, "end_pos": 20175922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064131.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064131.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056561.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 383, "start_aa": "Thr", "end_pos": 383, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr383", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 430, "start_aa": "Thr", "end_pos": 430, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr430", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 550, "start_aa": "Thr", "end_pos": 550, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr550", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 93, "start_aa": "Thr", "end_pos": 93, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr93", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506074", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506074", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AT65-1", "protein_name": "Family with sequence similarity 222 member B", "gene_name": "FAM222B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAAAKAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALSHQGLQHPPNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRAPTGYPSDLKPVAWNQHQLAHLQQMCSEAGGTPAPGLTGKHAAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAVPFHGGQPAGAPLDCAAAAAAGAHYRAGTGGGPVASHNSLVQTVDYLSGDFQQACFREQSLALLSKAHRAPGSRAPDPTDSRSLHIQHPGYR", "length": 564 }, "evidence": [ { "id": "E1BFC5", "url": "https://omabrowser.org/oma/group/E1BFC5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9PK94-1", "protein_name": "Uncharacterized protein LOC561123", "gene_name": "fam222ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLACLPGPGDLSLQLHPHSQMNTGLQKWDTPQRMRSAQYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRNHIRRTVNGLDTAGPRYSPYPSSQATAKTGLLAIVKVPLVKGVIKDFDGTRARLHPEVIMNATGGPYAATSASTLNLHHPSQAPSRASQNPQGLPPHPQNLQTLQQQQPGPPHQGLGHRPSSSIPPQHQGLPRPQTLCHAASLGHPSTHPPSAILLPQQHLQNPPASLQVGARKLPVADAPPNVTVSTSTIPLSMAGGLHQGRQADLNSIVHQISQFCQARAQGAGATSMCEGQIANPSPISRNLLINASSRVSVHAGNPNALAPGLMHPSFAIGPPDKMTASAPVSAAPPHNIGAMNHMYHSDLKQQHLQHQSHQLQRNPQHPHMRSWTQHQLPHLQHISEGGGHPCKPPGHDPGLSCKGITYPPEMSMGQPYAMKPSSPSPPLVNNNSSNAMPPGAVTHYTNGQYYHQPPVWGSILPTPNSDSSGSQDLPVSFHGTGTGNTNPTPGMDCGPTGGAAHYRLVGGALIGQTNLIQTADCMGGDFQTPCFRDQNLILMGKMHRPPPMGRVLVPPSETQGQHPGYR", "length": 595 }, "evidence": [ { "id": "E1BFC5", "url": "https://omabrowser.org/oma/group/E1BFC5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0L6G3-1", "protein_name": "Family with sequence similarity 222, member B", "gene_name": "Fam222b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNAGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARVLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALTHQGLQHPPNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRAPTGYPSDLKPVTWNQHQLAHLQQMCSEAGGTPAPGLTGKHTAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGLPAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGQPTGAPLDCGAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGARAPEPTDSRSLHIQHPGYR", "length": 562 }, "evidence": [ { "id": "E1BFC5", "url": "https://omabrowser.org/oma/group/E1BFC5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P539-1", "protein_name": "Protein FAM222B", "gene_name": "Fam222b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLACLPGPGDLSLQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARFLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQQMAQTQGLVHPQALTHQGLQHPPNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRAPTGYPSDLKPVTWNQHQLAHLQQMCSEAGGTPAPGLTGKHTAGRELAGPGFVGKAAAYPQELCLAQSFHLKPPLEKPTPSPPVNGLPAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLTMPFHGGQPTGAPLDCGAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGTRAPDPTDSRSLHIQHPGYR", "length": 562 }, "evidence": [ { "id": "E1BFC5", "url": "https://omabrowser.org/oma/group/E1BFC5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WU58-1", "protein_name": "Protein FAM222B", "gene_name": "FAM222B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALAHQGLQHPHNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRVPTGYPSDLKPVTWNQHQLAHLQQMCSEASGTPAPGLTGKHAAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGMAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGQPTGAPLDCAAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTESRSLHIQHPGYR", "length": 562 }, "evidence": [ { "id": "E1BFC5", "url": "https://omabrowser.org/oma/group/E1BFC5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BFC5", "url": "https://www.uniprot.org/uniprotkb/E1BFC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFC5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 563, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFC5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFC5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41, 93, 383, 430, 550 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 305, "end_pos": 307 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGP1-1", "uniprot_ac": "E1BGP1", "uniprot_id": "E1BGP1_BOVIN", "mass": { "chemical_mass": 88830.0, "monoisotopic_mass": 88830.0 }, "refseq": { "ac": "XP_005201499", "name": "DISP complex protein LRCH3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201499" }, "gene_names": [ { "name": "LRCH3", "type": "recommended", "evidence": [ { "id": "E1BGP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP1" } ] }, { "name": "LRCH3", "type": "synonym", "evidence": [ { "id": "XP_005201499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201499" } ] } ], "protein_names": [ { "name": "DISP complex protein LRCH3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201499" } ] }, { "name": "Leucine rich repeats and calponin homology domain containing 3", "type": "synonym", "evidence": [ { "id": "E1BGP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGP1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRCH3", "url": "https://www.uniprot.org/uniprotkb/E1BGP1", "locus": { "chromosome": "1", "start_pos": 70227703, "end_pos": 70335679, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032839", "url": "https://www.ensembl.org/id/ENSBTAG00000032839" } ] } } ], "crossref": [ { "id": "E1BGP1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21272", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21272", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786557", "url": "https://www.ncbi.nlm.nih.gov/gene/786557", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CMLYSWI", "url": "https://omabrowser.org/oma/group/CMLYSWI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRH8", "url": "https://www.orthodb.org/?gene=A0A3Q1LRH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVY6", "url": "https://www.orthodb.org/?gene=A0A3Q1LVY6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZZ9", "url": "https://www.orthodb.org/?gene=A0A3Q1LZZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBN3", "url": "https://www.orthodb.org/?gene=A0A3Q1MBN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N6B7", "url": "https://www.orthodb.org/?gene=A0A3Q1N6B7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJA2", "url": "https://www.orthodb.org/?gene=A0A3Q1NJA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJL8", "url": "https://www.orthodb.org/?gene=A0A3Q1NJL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BGP1", "url": "https://www.orthodb.org/?gene=E1BGP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201499", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201499", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVY6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVY6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZZ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6B7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6B7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJA2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGP1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVSLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNLCSPSDILQLNLSVKRTVETLLSLGAHSEESSFVSLSIQLLGFVAFYCTLMLTLCMLYYWIFPL", "length": 796, "header": "tr|E1BGP1-1|E1BGP1_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=3 CANONICAL=E1BGP1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRH8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1LRH8-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVSLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQLERKFNI", "length": 737, "header": "tr|A0A3Q1LRH8-1|E1BGP1_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=2 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70228403, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079007.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079007.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057653.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057653.2" } ] } }, { "isoform_ac": "A0A3Q1LVY6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1LVY6-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAV", "length": 714, "header": "tr|A0A3Q1LVY6-1|A0A3Q1LVY6_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70230440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077107.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077107.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064836.1" } ] } }, { "isoform_ac": "A0A3Q1LZZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1LZZ9-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGENDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAV", "length": 731, "header": "tr|A0A3Q1LZZ9-1|A0A3Q1LZZ9_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70230440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080277.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080277.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062928.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062928.1" } ] } }, { "isoform_ac": "A0A3Q1MBN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1MBN3-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAV", "length": 749, "header": "tr|A0A3Q1MBN3-1|A0A3Q1MBN3_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70230440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080309.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080309.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068145.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068145.1" } ] } }, { "isoform_ac": "A0A3Q1N6B7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1N6B7-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGESLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAV", "length": 755, "header": "tr|A0A3Q1N6B7-1|A0A3Q1N6B7_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70230440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065969.1" } ] } }, { "isoform_ac": "A0A3Q1NJA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1NJA2-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQKEEVDIPRGPPHPSPLLPFTQASPPPSLPLLDAFPFCCYFC", "length": 747, "header": "tr|A0A3Q1NJA2-1|A0A3Q1NJA2_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=2 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70235056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086219.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086219.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072199.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072199.2" } ] } }, { "isoform_ac": "A0A3Q1NJL8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0A3Q1NJL8-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKSLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAV", "length": 738, "header": "tr|A0A3Q1NJL8-1|A0A3Q1NJL8_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=2 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70230440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080958.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080958.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072383.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072383.2" } ] } }, { "isoform_ac": "A0AAA9TKX8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0AAA9TKX8-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQLERKFNI", "length": 713, "header": "tr|A0AAA9TKX8-1|A0AAA9TKX8_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70228403, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120182.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120182.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099100.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099100.1" } ] } }, { "isoform_ac": "A0AAA9TTQ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#A0AAA9TTQ3-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKSLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAMTVQALLELAPPKQQQQQHQLSAVWKENLTFSLARL", "length": 750, "header": "tr|A0AAA9TTQ3-1|A0AAA9TTQ3_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=1 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70228387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100463.1" } ] } }, { "isoform_ac": "E1BGP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1/entry#E1BGP1-1", "sequence": { "sequence": "MAAAGLVAVAAAAEYSCPGASGGNLSAVNCGPNSGAGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYVPEAILNLQALTFLNISRNQLSTLPVHLCELPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKIHIFKYLNMQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRENQYQENHSSLVVTNGGVEHELDQIDYIDSCTAEEDEDEVRPHKGLDSDSLSSQFMAYIEQRRISHEGSPIKPIPMREFQKTEDMRRYSHQNRVPAEPSSLLSVSPSHNQTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHTPLVGECPFPSRRSQHTDDSALLVSLSGVNQVGYAAPLPPASAFRPLQNDDRSNAVSNSPTTETAHHSPAYSFPAAIQRNQPQRPESFLFRGAVRTETNKGHASPLLSSSVPTTDLKDPVTRQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNLCSPSDILQLNLSVKRTVETLLSLGAHSEESSFVSLSIQLLGFVAFYCTLMLTLCMLYYWIFPL", "length": 796, "header": "tr|E1BGP1-1|E1BGP1_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 3 OS=Bos taurus OX=9913 GN=LRCH3 PE=4 SV=3 CANONICAL=E1BGP1-1" }, "locus": { "chromosome": "1", "start_pos": 70335480, "end_pos": 70233705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025116.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025116.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025116.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025116.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AT50-1", "protein_name": "Leucine rich repeats and calponin homology domain containing 3", "gene_name": "LRCH3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAGLVAVATATEYSGPGTSGGNLSVVNCGPNSGTGPGPGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLESLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVRLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQMITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPMGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRREGQYQENRSSLVVTNGGVEHDLDQIDYIDSCTAEEEEDEVRPPKGLDSDSLSSQFMAYIEQRRISHEGSPVKPVPMREFQKSEDMRRYSHQSRVPVEPSSLLSLSPSHNQFSHTDLELHRRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKAAQSPQKQQSPLDGECPFPSRRSQHTDDSALLVSLSGVNQVGCATTLPHSSAIRPIKNDDRSNAVSSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRGAVRGETNKGHTSSLLPSTAPTTDSADSVARQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNLCSPSDILQLNLSVKRTVETLLSLGAHSEESSFVSLSMQLLGFVAFYCTLMLTLCMLYYWIFPL", "length": 799 }, "evidence": [ { "id": "E1BGP1", "url": "https://omabrowser.org/oma/group/E1BGP1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M2BKV2-1", "protein_name": "DISP complex protein LRCH3 isoform X1", "gene_name": "lrch3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAASVLLSAESAVPSFTVGHPAGAIAAGGTTHHGLSNAPGPASWNRSLDRALDEAAATGGLNLSGRKLKEFPRSAAGHDLTDTTRADLSRNRLTELPVEVCMFVSLENLNLYQNCLRSLPESLINLQSLTYLNLSRNQLSTLPAHLCRLPLKVLIACNNKLVSLPEDLGKLRQLTELDVSCNEIQTLPPQIGQLEALRDLNIRRNHLVRLPPELAELPLVRLDFSCNKVTSIPVCYRNLRHLQSIILDNNPLQSPPAQICIKGKIHIFKYLNMEACKAASELPDYDRRPLPFGSCVEDLYSGRPYGALDSGFNSVDSGDKRWSGNEPSDELSDLPLRVAEITKEQRQRRERDDHRTATHITNGTMESEMEQIDFIDSCTAEDDDEEGRSRRVESVSLSSQFMAYIERRITREGSPVKTSPSRTDDPRRQTSLHNRGGSDSSGSSSYAHNQRSAGGGVERVRREAQLAALRYEEERQKTRSVQRDAVMNFVKHKSSQSPTKLSPTDSESLYPSRRSTHTDDSALFMSDFEPLLIFEIDTDTNTIKKRPDSHKQSLSAVLLDGCVSPTMSIAPFCTQQQGEDYASPTALQSPSYPSPAALSPSRGPNQRPESYLFRLSQREEKKKGESGTQKAEPVEATPTQSPAPTGEEALLIEQLRRNIECRLKVSLPSDLGAALTDGVVLCHLANHVRPRSIPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQDSLCSAGDVLEGELVCVFRLVEALLSLAPPPLRHAPSSQLAGFALFYLSIMSLLCAIYCHLVPSV", "length": 794 }, "evidence": [ { "id": "E1BGP1", "url": "https://omabrowser.org/oma/group/E1BGP1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZWD1-1", "protein_name": "Leucine rich repeats and calponin homology domain containing 3", "gene_name": "Lrch3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAGLVAVVAAAEYSGPVGSGGNLSGANCGPSPGLGPGSWSRSVDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMETCHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGQLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVPLIRLDFSCNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDYERRPLGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRSSVVVTNGGVDHDLDQIDYIDSCTTEEEENDVKRPKSLDTSSLSSQFLAYIEQRRISHEGSPVKPIAVRDFQKTEDMKRYSHQNRVPVEPSLVLSVPPSHNQLSHSDLELHQRGEQSVERARREAQLAALQYEGEKIRTKQIQRDAGLDFVKHKVSQNPQKQQPPGNGECPFPSRRSQHTDDSALLVSLSGLDGVSCVATRPHSSAFTPLKSNDRVDVTSSFPMTDTARHSPAYSFPAATQRNQPQRPESFLFRATVRAEASKGRASPLLSSAPATDAADSIARQREEELRLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQDSLCSPSDILQLNLSVKRTVEMLLSLGAHAEESSFVSLSVQLLGFVAFYCSLMLILCVLYYRVFTYS", "length": 791 }, "evidence": [ { "id": "E1BGP1", "url": "https://omabrowser.org/oma/group/E1BGP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BVU0-1", "protein_name": "DISP complex protein LRCH3", "gene_name": "Lrch3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAGLVAVVAAAEYSGPVASGGNLSGATCGPSPGLGPGPGPGSWSRSVDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVPLIRLDFSCNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDYERRPLGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRSSVAVTNGGVEHDLDQIDYIDSCTTEEEENDVKQPKSLDTNSLSSQFMAYIEQRRISHEVSPVKPIAVREFQKTEDMKRYSHQNRVPVEPSLVLSMPPSHNQLSHSDLELHQRREQSIECTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASHNPQRQQPPGNGECSFPSRRSQHTDDSALLVSLSGLDGVSCVATRPHSSAFTPLKSENRVDVTSSFPMTETVHHSPAYSFPAATQRNQPQRPESFLFRAAVRAEANKGRASPLLLSSAPATDPTDAITRQREEELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELAPPKQPPPQQPQQQQPQLSAV", "length": 778 }, "evidence": [ { "id": "E1BGP1", "url": "https://omabrowser.org/oma/group/E1BGP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96II8-1", "protein_name": "DISP complex protein LRCH3", "gene_name": "LRCH3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV", "length": 777 }, "evidence": [ { "id": "E1BGP1", "url": "https://omabrowser.org/oma/group/E1BGP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BGP1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "septin cytoskeleton organization", "id": "GO:0032185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032185", "evidence": [ { "database": "UniProtKB", "id": "E1BGP1", "url": "https://www.uniprot.org/uniprotkb/E1BGP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 743, "end_pos": 745, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 796, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGP1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP1" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 646, "end_pos": 761, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 24, "end_pos": 26 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 743, "end_pos": 745 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKM1-1", "uniprot_ac": "E1BKM1", "uniprot_id": "E1BKM1_BOVIN", "mass": { "chemical_mass": 45978.0, "monoisotopic_mass": 45978.0 }, "refseq": {}, "gene_names": [ { "name": "CEACAM16", "type": "recommended", "evidence": [ { "id": "E1BKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ] } ], "protein_names": [ { "name": "Cell adhesion molecule CEACAM16", "type": "recommended", "evidence": [ { "id": "E1BKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM1/entry#names_and_taxonomy" } ] }, { "name": "Carcinoembryonic antigen-related cell adhesion molecule 16", "type": "synonym", "evidence": [ { "id": "E1BKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRQ9#function" }, { "database": "UniProtKB", "id": "ARBA00054879", "url": "https://www.uniprot.org/uniprotkb/ARBA00054879#function" }, { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEACAM16", "url": "https://www.uniprot.org/uniprotkb/E1BKM1", "locus": { "chromosome": "18", "start_pos": 52488828, "end_pos": 52480186, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037983", "url": "https://www.ensembl.org/id/ENSBTAG00000037983" } ] } } ], "crossref": [ { "id": "E1BKM1", "url": "https://alphafold.ebi.ac.uk/entry/E1BKM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037983", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037983", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05740", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05740", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05774", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05774", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44427:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44427:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LRQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLIRSRWLLLSAAILSAGAEIIITPEPAQPAEGDNVTLAVQGLSGELLAYNWYAGPTLSLSYLVASYIVSTGDETPGPAHTGREAVRPDGGLDIQGALPGHSGTYILQTLNRQFQTEVGYGHMQVYEILAQPVVVANSTALVERRDTLHLTCSSPSPAEVRWFFNGDALPIAVRLGLSPNGRVLTRHGIRREEAGAYQCEVWNPVSVSRSEPVNLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGRALKSDQDHLNISSMTATQEGTYTCIAKNPKTLLSGSASVVVKLSAATVIMTIVPVPTRPMEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFPNCSLLVQKLNLTDAGRYTLKTVTLQGKTETLEVELQVALLE", "length": 424, "header": "tr|E1BKM1-1|E1BKM1_BOVIN Isoform 1 of Cell adhesion molecule CEACAM16 OS=Bos taurus OX=9913 GN=CEACAM16 PE=3 SV=4 CANONICAL=E1BKM1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRQ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1/entry#A0A3Q1LRQ9-1", "sequence": { "sequence": "MVLIRSRWLLLSAAILSAGAEIIITPEPAQPAEGDNVTLAVQGLSGELLAYNWYAGPTLSLSYLVASYIVSTGDETPGPAHTGREAVRPDGGLDIQGALPGHSGTYILQTLNRQFQTEVGYGHMQVYEILAQPVVVANSTALVERRDTLHLTCSSPSPAEVRWFFNGDALPIAVRLGLSPNGRVLTRHGIRREEAGAYQCEVWNPVSVSRSEPVNLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGRALKSDQDHLNISSMTATQEGTYTCIAKNPKTLLSGSASVVVKLSAATVIMTIVPVPTRPMEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFPNCSLLVQKLNLTDAGRYTLKTVTLQGKTETLEVELQVARECAGGDGRGGSFQTRAPKSGESS", "length": 445, "header": "tr|A0A3Q1LRQ9-1|E1BKM1_BOVIN Computationally mapped isoform of Cell adhesion molecule CEACAM16 OS=Bos taurus OX=9913 GN=CEACAM16 PE=3 SV=2 CANONICAL=E1BKM1-1" }, "locus": { "chromosome": "18", "start_pos": 52487082, "end_pos": 52480667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072842.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072842.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062966.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062966.2" } ] } }, { "isoform_ac": "E1BKM1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1/entry#E1BKM1-1", "sequence": { "sequence": "MVLIRSRWLLLSAAILSAGAEIIITPEPAQPAEGDNVTLAVQGLSGELLAYNWYAGPTLSLSYLVASYIVSTGDETPGPAHTGREAVRPDGGLDIQGALPGHSGTYILQTLNRQFQTEVGYGHMQVYEILAQPVVVANSTALVERRDTLHLTCSSPSPAEVRWFFNGDALPIAVRLGLSPNGRVLTRHGIRREEAGAYQCEVWNPVSVSRSEPVNLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGRALKSDQDHLNISSMTATQEGTYTCIAKNPKTLLSGSASVVVKLSAATVIMTIVPVPTRPMEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFPNCSLLVQKLNLTDAGRYTLKTVTLQGKTETLEVELQVALLE", "length": 424, "header": "tr|E1BKM1-1|E1BKM1_BOVIN Isoform 1 of Cell adhesion molecule CEACAM16 OS=Bos taurus OX=9913 GN=CEACAM16 PE=3 SV=4 CANONICAL=E1BKM1-1" }, "locus": { "chromosome": "18", "start_pos": 52488611, "end_pos": 52480667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019915.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019915.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019915.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019915.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "pmid": "" }, { "name": "stereocilium tip", "id": "GO:0032426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032426", "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "E1BKM1", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 133, "end_pos": 217, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 244, "end_pos": 246 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 393, "end_pos": 395 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5EA76-1", "uniprot_ac": "Q5EA76", "uniprot_id": "INT14_BOVIN", "mass": { "chemical_mass": 57406.0, "monoisotopic_mass": 57406.0 }, "refseq": { "ac": "NP_001015652", "name": "integrator complex subunit 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" }, "gene_names": [ { "name": "INTS14", "type": "recommended", "evidence": [ { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ] }, { "name": "C10H15orf44", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "C15orf44", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "INTS14", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "VWA9", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" }, { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 14", "type": "recommended", "evidence": [ { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#names_and_taxonomy" } ] }, { "name": "UPF0464 protein C15orf44 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "integrator complex subunit 14", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "von Willebrand factor A domain containing 9", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" } ] }, { "name": "von Willebrand factor A domain-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001015652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652" }, { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76#function" }, { "database": "UniProtKB", "id": "Q96SY0", "url": "https://www.uniprot.org/uniprotkb/Q96SY0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS14", "url": "https://www.uniprot.org/uniprotkb/Q5EA76", "locus": { "chromosome": "10", "start_pos": 12466744, "end_pos": 12500813, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015158", "url": "https://www.ensembl.org/id/ENSBTAG00000015158" } ] } } ], "crossref": [ { "id": "Q5EA76", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534159", "url": "https://www.ncbi.nlm.nih.gov/gene/534159", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534159", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534159", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSSVVWI", "url": "https://omabrowser.org/oma/group/QSSVVWI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGY5", "url": "https://www.orthodb.org/?gene=A0A3Q1MGY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJ02", "url": "https://www.orthodb.org/?gene=A0A3Q1MJ02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EA76", "url": "https://www.orthodb.org/?gene=Q5EA76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13532", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13532", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13532:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13532:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20504", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20504", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015652", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ02", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ02-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA76-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRGESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMVQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNITPLQTDFSGSSAERI", "length": 518, "header": "sp|Q5EA76-1|INT14_BOVIN Isoform 1 of Integrator complex subunit 14 OS=Bos taurus OX=9913 GN=INTS14 PE=2 SV=1 CANONICAL=Q5EA76-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGY5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#A0A3Q1MGY5-1", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRGESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMVQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNENIS", "length": 506, "header": "tr|A0A3Q1MGY5-1|A0A3Q1MGY5_BOVIN Computationally mapped isoform of Integrator complex subunit 14 OS=Bos taurus OX=9913 GN=INTS14 PE=3 SV=2 CANONICAL=Q5EA76-1" }, "locus": { "chromosome": "10", "start_pos": 12496313, "end_pos": 12467079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066973.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066973.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069884.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069884.2" } ] } }, { "isoform_ac": "A0A3Q1MJ02-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#A0A3Q1MJ02-1", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRGESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGKTFLPFVDPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMVQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNITPLQTDFSGSSAERI", "length": 512, "header": "tr|A0A3Q1MJ02-1|A0A3Q1MJ02_BOVIN Computationally mapped isoform of Integrator complex subunit 14 OS=Bos taurus OX=9913 GN=INTS14 PE=3 SV=2 CANONICAL=Q5EA76-1" }, "locus": { "chromosome": "10", "start_pos": 12496313, "end_pos": 12467323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085565.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085565.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074314.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074314.2" } ] } }, { "isoform_ac": "A0AAA9S3R6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#A0AAA9S3R6-1", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQVVLVTDGCLGIGRGSLRHSLATHNQRGESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMVQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNITPLQTDFSGSSAERI", "length": 482, "header": "tr|A0AAA9S3R6-1|A0AAA9S3R6_BOVIN Computationally mapped isoform of von Willebrand factor A domain-containing protein 9 OS=Bos taurus OX=9913 GN=INTS14 PE=4 SV=1 CANONICAL=Q5EA76-1" }, "locus": { "chromosome": "10", "start_pos": 12496313, "end_pos": 12467323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105629.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105629.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077916.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077916.1" } ] } }, { "isoform_ac": "Q5EA76-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA76/entry#Q5EA76-1", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRGESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMVQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNITPLQTDFSGSSAERI", "length": 518, "header": "sp|Q5EA76-1|INT14_BOVIN Isoform 1 of Integrator complex subunit 14 OS=Bos taurus OX=9913 GN=INTS14 PE=2 SV=1 CANONICAL=Q5EA76-1" }, "locus": { "chromosome": "10", "start_pos": 12496313, "end_pos": 12467323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020164.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020164.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020164.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020164.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534159", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534159", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1THU5-1", "protein_name": "Integrator complex subunit 14", "gene_name": "INTS14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATHSQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPESFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAGYDHNITPLQTDFSGSSTERM", "length": 518 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HUX8-1", "protein_name": "Integrator complex subunit 14", "gene_name": "Ints14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVVKCGHLTADVQVFPRPEPFVTDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTGTSEYAAYDHNITPLHTDFSGSSTERM", "length": 518 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1LWK5-1", "protein_name": "Integrator complex subunit 14", "gene_name": "ints14", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPTVVLMDSSLSMTRPVSVEGSEEFQRKNLAVHGLTMLFEHMATNYKLEFTSLVAFSSLWELMVPFTRDYNTLQEALNNLEDYDKTCLEGALQGVSNVVQQEWGSACPCQVVLVTDGALGIGRGSLRHSLQTVKQRGEDKKFPLPFPFPSKLYIMCIANAEELQATDGMDNLEQLINLNGGDGQIYTMEGPLCLKSVQSMFGKLIDQAYSPFHAVLRCGNLTSDVQVFPRPEPVIIDEEVDPMPKNVQTDLEIVGFIEIGDISSPPVLSRHLVLPIAVNKEGDEIGTGTTDDTEEDTSTNQMAGKSPNFCVLLHGSLKVEGMVALVQLGPDWYGMLYSQADSKKKSNLMMSLFDPGSEPLPWLGRMSQLGPASDAAENPYGEDDSKSPFPIQPKHKRSYAQNVTVWIKASGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFWELLKSMAELLERECTLLPDSAHPDAAFQLSHAAQQLKLASSIDSKYAAFEHNITPMLTDFSGGGGDRI", "length": 518 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5ZK21-1", "protein_name": "Integrator complex subunit 14", "gene_name": "INTS14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAVHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALLGVCNIVQQEWGAAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTSDVQVFPRPEPFIIDEEIDPIPKAINTDLEIVGFVDIADISSPPVLSRHLVLPIALNREGDEVGPGITDDTEDENSANQIAGKIPNFCVLLHGSLKVEGMVAVVQLGPEWYGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGDDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKVASTGASEYTAYDHNIAPLQTDFPTTSTERM", "length": 518 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q66H58-1", "protein_name": "Integrator complex subunit 14", "gene_name": "Ints14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESSRFPLPFPFPSKLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAALKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGAGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVALVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTEYAVYDLNITPLHTDFSGSSTERM", "length": 515 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R3P6-1", "protein_name": "Integrator complex subunit 14", "gene_name": "Ints14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGAGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVALVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTEYAIYDHNITPLHTDFSGSSTERM", "length": 515 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96SY0-1", "protein_name": "Integrator complex subunit 14", "gene_name": "INTS14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI", "length": 518 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPY0-1", "protein_name": "Integrator complex subunit 14", "gene_name": "IntS14", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPTLIALDASLSMLRPVPGRNEHTYQSLATKGIQHLLDNLTAAGKLEHVALLSYSTTAELKVDFTRDYDQVRQAVKKVEPVDKACLMSMLKAVVSIMSPWGNQNILQVVVFTDCGLGFGNTSITGFLEAYAEKESEPEFGFLKTLANYNLNFICLGLHGDYYFTRGLAVYQQLLDKVSLKGQLFMTKPAKSSDAVEGNPNPNPNPSHKSELGRTTVFELIERLCEASYKSSEVTLKCGSYFRMEASVLLWPPTAPYEQKSHIFGREPTIRHTDQKIEVCGFLSLSDIGSPATLSRHWVLPKVEREKSGSSRRSGNLSAAAKPPKLNLDTSNPNYELEKLEADIKEFYAKDSKDTEESGDDDVTIVLKPGPQTEQQKENLCVLLHGALKMENMAALVRVGDKWYGFIYAFTDSKKKSNLMLNILPPGTNVIPWLGDLESLGFPEDLAPGETASFPVRADRRSYSQSSVVWIRQASLQSDVQKVLRHAKKMPDKTQHFYKELNRIRRAALALGFVELLEALAMLLEKECAHLSLNGASNDCTLQLQHAATELRKTSNRDMKSMIVPLQKVGASDAGSTAATAPAPAYMY", "length": 587 }, "evidence": [ { "id": "Q5EA76", "url": "https://omabrowser.org/oma/group/Q5EA76/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription elongation by RNA polymerase II", "id": "GO:0034243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034243", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" }, { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" }, { "name": "RNA polymerase II transcription initiation surveillance", "id": "GO:0160240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160240", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" }, { "name": "INTAC complex", "id": "GO:0160232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160232", "evidence": [ { "database": "UniProtKB", "id": "Q5EA76", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA76-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 518, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA76" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76#function" }, { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "binding_site_uniprot": 10, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 10, "end_pos": 10, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76#function" }, { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "binding_site_uniprot": 12, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 12, "end_pos": 12, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76#function" }, { "id": "Q5EA76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA76" } ], "binding_site_uniprot": 86, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 86, "end_pos": 86, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 385, "end_pos": 387 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 502, "end_pos": 504 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8MJJ1-1", "uniprot_ac": "Q8MJJ1", "uniprot_id": "SPG21_BOVIN", "mass": { "chemical_mass": 35006.0, "monoisotopic_mass": 35006.0 }, "refseq": { "ac": "NP_991341", "name": "maspardin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" }, "gene_names": [ { "name": "SPG21", "type": "recommended", "evidence": [ { "id": "Q8MJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ] }, { "name": "SPG21", "type": "synonym", "evidence": [ { "id": "NP_991341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" } ] } ], "protein_names": [ { "name": "Maspardin", "type": "recommended", "evidence": [ { "id": "Q8MJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#names_and_taxonomy" } ] }, { "name": "SPG21, maspardin", "type": "synonym", "evidence": [ { "id": "NP_991341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" } ] }, { "name": "Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog", "type": "synonym", "evidence": [ { "id": "Q8MJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#names_and_taxonomy" } ] }, { "name": "maspardin", "type": "synonym", "evidence": [ { "id": "NP_991341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" } ] }, { "name": "spastic paraplegia 21 (autosomal recessive, Mast syndrome)", "type": "synonym", "evidence": [ { "id": "NP_991341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" } ] }, { "name": "spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog", "type": "synonym", "evidence": [ { "id": "NP_991341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341" } ] } ], "function": [ { "annotation": "May play a role as a negative regulatory factor in CD4-dependent T-cell activation.", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1#function" }, { "database": "UniProtKB", "id": "A0A3Q1NKA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKA0#function" }, { "database": "UniProtKB", "id": "ARBA00002271", "url": "https://www.uniprot.org/uniprotkb/ARBA00002271#function" }, { "database": "UniProtKB", "id": "A0AAA9SAG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG6#function" }, { "database": "UniProtKB", "id": "A0AAA9SJQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ4#function" }, { "database": "UniProtKB", "id": "A0AAF6YWA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWA8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPG21", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1", "locus": { "chromosome": "10", "start_pos": 11906132, "end_pos": 11926697, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011540", "url": "https://www.ensembl.org/id/ENSBTAG00000011540" } ] } } ], "crossref": [ { "id": "Q8MJJ1", "url": "https://alphafold.ebi.ac.uk/entry/Q8MJJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011540", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011540", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404069", "url": "https://www.ncbi.nlm.nih.gov/gene/404069", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404069", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYVQPQK", "url": "https://omabrowser.org/oma/group/CYVQPQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKA0", "url": "https://www.orthodb.org/?gene=A0A3Q1NKA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8MJJ1", "url": "https://www.orthodb.org/?gene=Q8MJJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15913:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15913:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_991341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991341", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJJ1-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 308, "header": "sp|Q8MJJ1-1|SPG21_BOVIN Isoform 1 of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=2 SV=1 CANONICAL=Q8MJJ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NKA0-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#A0A3Q1NKA0-1", "sequence": { "sequence": "MVTAGVTQLHPFLAAWPHPSEPGSSRLAPAARTIPEEGGRRSGLARSRAPPLGGRPSSAPPRLAALTDSERSGLQPQPGPQQPPRPAPFLEGRAALGGGTGTWGRPRQLFLHIQASRNTCTPLYSLVESVSNSTCTIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 423, "header": "tr|A0A3Q1NKA0-1|A0A3Q1NKA0_BOVIN Computationally mapped isoform of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=3 SV=2 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11926415, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073008.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073008.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072725.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072725.2" } ] } }, { "isoform_ac": "A0AAA9S8V2-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#A0AAA9S8V2-1", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIAVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 281, "header": "tr|A0AAA9S8V2-1|A0AAA9S8V2_BOVIN Computationally mapped isoform of SPG21 abhydrolase domain containing, maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=3 SV=1 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11922270, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081713.1" } ] } }, { "isoform_ac": "A0AAA9SAG6-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#A0AAA9SAG6-1", "sequence": { "sequence": "HPSEPGSSRLAPAARTIPEEGGRRSGLARSRAPPLGGRPSSAPPRLAALTDSERSGLQPQPGPQQPPRPAPFLEGRAALGGGTGTWGRPRQLQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 324, "header": "tr|A0AAA9SAG6-1|A0AAA9SAG6_BOVIN Computationally mapped isoform of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=3 SV=1 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11926364, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118332.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118332.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080431.1" } ] } }, { "isoform_ac": "A0AAA9SJQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#A0AAA9SJQ4-1", "sequence": { "sequence": "MSDLELTLESLWASSRRPRPRQSGCQLCSRQDVRRKPESLSLCGPTRPVAMVTAGVTQLHPFLAAWPHPSEPGSSRLAPAARTIPEEGGRRSGLARSRAPPLGGRPSSAPPRLAALTDSERSGLQPQPGPQQPPRPAPFLEGRAALGGGTGTWGRPRQIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 445, "header": "tr|A0AAA9SJQ4-1|A0AAA9SJQ4_BOVIN Computationally mapped isoform of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=3 SV=1 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11926565, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102792.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102792.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084140.1" } ] } }, { "isoform_ac": "A0AAF6YWA8-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#A0AAF6YWA8-1", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKLFLHIQASRNTCTPLYSLVESVSNSTCTIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 336, "header": "tr|A0AAF6YWA8-1|A0AAF6YWA8_BOVIN Computationally mapped isoform of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=3 SV=1 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11922270, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015332.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015332.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015332.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015332.5" } ] } }, { "isoform_ac": "Q8MJJ1-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1/entry#Q8MJJ1-1", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTASSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 308, "header": "sp|Q8MJJ1-1|SPG21_BOVIN Isoform 1 of Maspardin OS=Bos taurus OX=9913 GN=SPG21 PE=2 SV=1 CANONICAL=Q8MJJ1-1" }, "locus": { "chromosome": "10", "start_pos": 11922270, "end_pos": 11906694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097669.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097669.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081391.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 304, "end_pos": 304, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "site_lbl": "Ser304" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of novel bovine RPE and retinal genes by subtractive hybridization.", "journal": "Mol. Vis.", "date": "2002", "authors": "Sharma Shiwani, Chang Jinghua T, Della Neil G, Campochiaro Peter A, Zack Donald J", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "reference": [ { "type": "PubMed", "id": "12131876", "url": "https://glygen.org/publication/PubMed/12131876" } ] } ], "pathway": [ { "id": "bta:404069", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404069", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U0H4-1", "protein_name": "Maspardin", "gene_name": "SPG21", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRNIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVQSLILCNAFSDTSIFNQTWTANSFWLMPSFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGNLGISQEEQ", "length": 308 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1C0Z8-1", "protein_name": "Maspardin", "gene_name": "SPG21", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKVWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVQSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFASGPVDPEMADGIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYIQIHLLQFHGTRYAAIDPSMVSAEELEVQKISLHTSSEQEEQ", "length": 310 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HUZ3-1", "protein_name": "Maspardin", "gene_name": "Spg21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLALSQEEP", "length": 308 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54I38-1", "protein_name": "Maspardin", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKLNQSDPYQLFRSWAPQNKISIGTLNEKIWKYYDYGPKDTNNAPIIFISHGSADIYFKQFLMLCPRGHRVISIQFSPYDTLSGWCKGFERFLDRLELDKPVHLFGSSLGGYLAQCFYQSKPSRVLSLILNNTFSDTQYFYDNSIGSSLFSLLPEFLLKKIILNNFPSGLLDNETREAVDFMVDQLETLNQNELASRLTLNCSPVSLLNPSGGLMDNITIIDCLDSTIPEKLREEVYKYYPNAKTALLKSGGDFSYLSRSDELNIHIEVHLRRFENLNNNNNNNNNNNNNNKDIKNNNEKQEVKIHQINNNNNNNNNNNNNNNNNNNNNIDKNNVNKIENNNNDIDIEGQNRISTTTISKNVSEATGKLNTSVFDNEDNDVFL", "length": 384 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIC4-1", "protein_name": "Maspardin", "gene_name": "Spg21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP", "length": 261 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQC8-1", "protein_name": "Maspardin", "gene_name": "Spg21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP", "length": 308 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZD8-1", "protein_name": "Maspardin", "gene_name": "SPG21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ", "length": 308 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9STI8-1", "protein_name": "Maspardin", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKGVSSTPGDYVYFKSQVPLHKIPIGTKQWRYYDFGPKTVPPLICIPGIAGTADVYYKQIMALSMKGYRVISVDIPRVWNYHEWIQAFEKFLDTIDVHHVHLYGTSLGGFLAQLFAHHRPRRVKSLVLSNTYLDTRTFATAMPWAPFVSWTPSFLLKRYVLTGIRDGPHEPFIADSVDFAVSQVETLSKDDLASRLTLTVDAASVGSLLLSDSSVTIMDTNDYCAIPQHLKDELTERYPEARRAYLKSGGDFPFLSRPDEVNLHLQLHLRRVGVEPRPEVVKSIPKGGADGTDGSSQSKKKSDEEKDDRNNNMPQDSGSSSSDQSPTFPESSGSSNDPPLPTDTIQLLSSSLNNLILVQLAGEVYQSCVVFTLCYCTLVLVHGGGFISRQLV", "length": 392 }, "evidence": [ { "id": "Q8MJJ1", "url": "https://omabrowser.org/oma/group/Q8MJJ1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "pmid": "" }, { "name": "trans-Golgi network transport vesicle", "id": "GO:0030140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030140", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "CD4 receptor binding", "id": "GO:0042609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042609", "evidence": [ { "database": "UniProtKB", "id": "Q8MJJ1", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MJJ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MJJ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MJJ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8MJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJJ1" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AB hydrolase-1", "eco_id": "ECO_0000255", "start_pos": 87, "end_pos": 159, "start_aa": "Phe", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 304 ], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 167, "end_pos": 169 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA26-1", "uniprot_ac": "Q5EA26", "uniprot_id": "DJC18_BOVIN", "mass": { "chemical_mass": 41603.0, "monoisotopic_mass": 41603.0 }, "refseq": { "ac": "NP_001015649", "name": "dnaJ homolog subfamily C member 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015649" }, "gene_names": [ { "name": "DNAJC18", "type": "recommended", "evidence": [ { "id": "Q5EA26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ] }, { "name": "DNAJC18", "type": "synonym", "evidence": [ { "id": "NP_001015649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015649" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 18", "type": "recommended", "evidence": [ { "id": "Q5EA26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA26/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 18", "type": "synonym", "evidence": [ { "id": "NP_001015649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015649" } ] }, { "name": "dnaJ homolog subfamily C member 18", "type": "synonym", "evidence": [ { "id": "NP_001015649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015649" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC18", "url": "https://www.uniprot.org/uniprotkb/Q5EA26", "locus": { "chromosome": "7", "start_pos": 50680729, "end_pos": 50712129, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002286", "url": "https://www.ensembl.org/id/ENSBTAG00000002286" } ] } } ], "crossref": [ { "id": "Q5EA26", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533660", "url": "https://www.ncbi.nlm.nih.gov/gene/533660", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015399", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015399", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533660", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533660", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TGQARHY", "url": "https://omabrowser.org/oma/group/TGQARHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA26", "url": "https://www.orthodb.org/?gene=Q5EA26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43908", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43908", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43908:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43908:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09320", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09320", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015649", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U047", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U047", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U047-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U047-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA26-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATLGSGERWTEAYIDAVRRNKYPEDRPPESHDPCGCCNCMKGQKEKKSENEWSQTRQGEGNSTYTEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFETDITPEELFNVFFGGHFPTGNIHMFSNVTDDTHYYRRRHRHERMQTRKEEEEDKPQTTYSAFIQLLPVLVIVIISVITQLLAANPPYSLFYKSTLGHTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG", "length": 358, "header": "sp|Q5EA26-1|DJC18_BOVIN Isoform 1 of DnaJ homolog subfamily C member 18 OS=Bos taurus OX=9913 GN=DNAJC18 PE=2 SV=1 CANONICAL=Q5EA26-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6U7-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA26/entry#A0AAA9S6U7-1", "sequence": { "sequence": "MAATLGSGERWTEAYIDAVRRNKYPEDRPPESHDPCGCCNCMKGQKEKKSENEWSQTRQGEGNSTYTEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFETDITPEELFNVFFGGHFPTGNIHMFSNVTDDTHYYRRRHRHERMQTRKEEEEDKPQTTYSAFIQLLPVLVIVIISVITQLLAANPPYSLFYKSTLGHTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQNDRNRRSDSILSQLP", "length": 332, "header": "tr|A0AAA9S6U7-1|A0AAA9S6U7_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member C18 OS=Bos taurus OX=9913 GN=DNAJC18 PE=4 SV=1 CANONICAL=Q5EA26-1" }, "locus": { "chromosome": "7", "start_pos": 50712073, "end_pos": 50684397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079635.1" } ] } }, { "isoform_ac": "A0AAA9U047-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA26/entry#A0AAA9U047-1", "sequence": { "sequence": "MAATLGSGERWTEAYIDAVRRNKYPEDRPPESHDPCGCCNCMKGQKEKKSENEWSQTRQGEGNSTYTEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFETDITPEELFNVFFGGHFPTGNIHMFSNVTDDTHYYRRRHRHERMQTRKEEEEDKPQTTYSAFIQLLPVLVIVIISVITQLLAANPPYSLFYKSTLGHTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQRWWLSGAATQPKCHLRTGSICPPDPAASAADMVKFSTWMEVVKINLLENKVQSWQNTEWKLLLAKSRS", "length": 385, "header": "tr|A0AAA9U047-1|A0AAA9U047_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member C18 OS=Bos taurus OX=9913 GN=DNAJC18 PE=4 SV=1 CANONICAL=Q5EA26-1" }, "locus": { "chromosome": "7", "start_pos": 50712073, "end_pos": 50684042, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127195.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127195.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103942.1" } ] } }, { "isoform_ac": "Q5EA26-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA26/entry#Q5EA26-1", "sequence": { "sequence": "MAATLGSGERWTEAYIDAVRRNKYPEDRPPESHDPCGCCNCMKGQKEKKSENEWSQTRQGEGNSTYTEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFETDITPEELFNVFFGGHFPTGNIHMFSNVTDDTHYYRRRHRHERMQTRKEEEEDKPQTTYSAFIQLLPVLVIVIISVITQLLAANPPYSLFYKSTLGHTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG", "length": 358, "header": "sp|Q5EA26-1|DJC18_BOVIN Isoform 1 of DnaJ homolog subfamily C member 18 OS=Bos taurus OX=9913 GN=DNAJC18 PE=2 SV=1 CANONICAL=Q5EA26-1" }, "locus": { "chromosome": "7", "start_pos": 50712073, "end_pos": 50683929, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002952.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002952.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002952.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002952.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533660", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533660", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C5R7-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member C18", "gene_name": "DNAJC18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTYTAEQLDGVRRIKSCRNYYEILGVERDATEEDLKKAYRRLALKFHPDKNRAPGATEAFKAIGNAFAVLSNPEKRLRYDEYGSDHEHVSTGQARHYNYYTEFEADITPEEIFNVFFGGHFPTGNIHMFSNVARDAHYYPRRHRNERAWTQEQEEEENRPQNSYSAFIQLMPIFIIIIVSVITQLMATNPPYSLFYKSSIGHVISRETENLQVPYYVDKNFEKNYQGAELQELERTVEKDYIDYIQTSCWKEKQQKSDLSNLAKLYRDERLKQKAESLKLEHCEKLSSLIGMHKGG", "length": 296 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RGF7-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member C18", "gene_name": "DNAJC18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAATLGGGERWTEAYIDAVRRNKYPEDRPPESHDPCGCCNCMKAQSEKKPENEWTQTRQGEGNATYTEEQLLGVQRIKKCRNYYEILGVSRNASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQMTFTAPRARPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTHYYRRRHRHERMQTRKEEEEDKPQTTYSAFIQLLPVLVIVIISVITQLLAANPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLLGLRRGG", "length": 358 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HVH7-1", "protein_name": "DnaJ homolog subfamily C member 18", "gene_name": "Dnajc18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAATLGSGERWTQAYIDAIRRNKYPEDRQPGSHDPCGCCNCMKAQKEKKSENEWNQTRQGEGSSTYTEEQLLGVQRIKKCRNYYEILGVSQNASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQMTFTAPRARSYHYYRDFEADISPEELFNVFFGGHFPSGNIHMFSNVTDDSHYYHRRHRHERTQTHKREEEDKPQTPYSAFVQLLPVLVIVVISVITQLLAANPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLRQKAESLKLENCEKLSKLIGLRRGG", "length": 358 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q0H8V1-1", "protein_name": "DnaJ heat shock protein family (Hsp40) member C18", "gene_name": "Dnajc18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATLGSGERWTQAYIDAIRRNKYPEDKQPDSHDPCGCCNCMKAQKEKKSENEWSQTRQGDGNATYTEEQLRGVQRIKKCRNYYDILGVSHNASDEELKKAYKKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTLTAPRARPYHYYRDVEADISPEELFNVFFGGHFPSGNIHMFSNVTDDSHYYRRRHRHERTQAHKREEDKSQTPYSAFVQLLPVLLIVTISVITQLLAANPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLRQKAESLKLENCAKLSKLIGLRRAG", "length": 357 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CZJ9-1", "protein_name": "DnaJ homolog subfamily C member 18", "gene_name": "Dnajc18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATTLGSGERWTQAYIDAIRRNKYPEDKRPDSHDPCGCCNCMKAQKEKKSENEWNQTRQGEGNATYTEEQLRGVQRIKKCRNYYDILGVSHNASDEELKKAYKKLALKFHPDKNCAPGATEAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTVPRARSYHYYKDFEADISPEELFNVFFGGHFPSGNIHMFSNVTDDSQYYRRRHRHERTQTHKREEDKSQTPYSAFVQLLPVLVIVTISVITQLLAANPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLRQKAESLKLENCAKLSKLIGLRRAG", "length": 357 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FFK2-1", "protein_name": "DNAJ heat shock N-terminal domain-containing protein", "gene_name": "MJJ3.16", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGNKDDALKCLKIGKDAIEAGDRSRALKFLEKARRLDPNLPIDGLVSDLKKQSDEPAAEEDSPGSAANESSKPSDRPSLRQRGSSSSAAGSSSSSSSTEEQRTIVREIKSKKDYYEILGLKSNCSVEDLRKSYRKLSLKVHPDKNKAPGSEEAFKSVSKAFQCLSNEDTRRKYDGSGSDEPAYQPRRDARRNNGFNGFYDDEFDADEIFRSFFGGGEMNPATTQFRSFNFGGGTRTANQASDTGFNPRVLLQILPVVFILLLNFLPSPQPIYSLSHRITTSSNSPRIGASLTL", "length": 294 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9H819-1", "protein_name": "DnaJ homolog subfamily C member 18", "gene_name": "DNAJC18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCMKAQKEKKSENEWTQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG", "length": 358 }, "evidence": [ { "id": "Q5EA26", "url": "https://omabrowser.org/oma/group/Q5EA26/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "pmid": "" }, { "name": "cellular response to misfolded protein", "id": "GO:0071218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071218", "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "Q5EA26", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA26-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA26-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA26" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA26" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 146, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA33-1", "uniprot_ac": "Q5EA33", "uniprot_id": "ANR49_BOVIN", "mass": { "chemical_mass": 27196.0, "monoisotopic_mass": 27196.0 }, "refseq": { "ac": "NP_001014965", "name": "ankyrin repeat domain-containing protein 49", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965" }, "gene_names": [ { "name": "ANKRD49", "type": "recommended", "evidence": [ { "id": "Q5EA33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ] }, { "name": "ANKRD49", "type": "synonym", "evidence": [ { "id": "NP_001014965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965" } ] }, { "name": "FGIF", "type": "synonym", "evidence": [ { "id": "NP_001014965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain-containing protein 49", "type": "recommended", "evidence": [ { "id": "Q5EA33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA33/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 49", "type": "synonym", "evidence": [ { "id": "NP_001014965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965" } ] }, { "name": "fetal globin inducing factor", "type": "synonym", "evidence": [ { "id": "NP_001014965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965" } ] } ], "function": [ { "annotation": "May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33#function" }, { "database": "UniProtKB", "id": "Q8VE42", "url": "https://www.uniprot.org/uniprotkb/Q8VE42#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD49", "url": "https://www.uniprot.org/uniprotkb/Q5EA33", "locus": { "chromosome": "15", "start_pos": 1532739, "end_pos": 1508947, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009176", "url": "https://www.ensembl.org/id/ENSBTAG00000009176" } ] } } ], "crossref": [ { "id": "Q5EA33", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA33", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540949", "url": "https://www.ncbi.nlm.nih.gov/gene/540949", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540949", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540949", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NRYVKPD", "url": "https://omabrowser.org/oma/group/NRYVKPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA33", "url": "https://www.orthodb.org/?gene=Q5EA33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TC79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA33-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKEKVNDEKPDPENSLDFSEHFNQLELLETHGHLIPTGTQSLWIGNSDDDEEQDEKTEEWYQLQEKKMEKDPSKLLLWAAEKNRLTTVQRLLSERATHVNTRDEDKYTPLHRAAYNGHLDVVRELIAHGADVHAVTVDGWTPLHSACKWNNARVASFLLQHDADVNAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNSLEETAFDIARRTGIYHYLFEIVEGCTNCSPQS", "length": 238, "header": "sp|Q5EA33-1|ANR49_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 49 OS=Bos taurus OX=9913 GN=ANKRD49 PE=2 SV=1 CANONICAL=Q5EA33-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TC79-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA33/entry#A0AAA9TC79-1", "sequence": { "sequence": "MEKEKVNDEKPDPENSLDFSEHFNQLELLETHGHLIPTGTQSLWIGNSDDDEEQDEKTEEWYQLQEKKMEKDPSKLLLWAAEKNRLTTVQRLLSERATHVNTRDEDKYTPLHRAAYNGHLDVVRELIAHGADVHAVTVDGWTPLHSACKWNNARVASFLLQHDADVNAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNSLEETAFDIARRTGIWILEDPKVLP", "length": 230, "header": "tr|A0AAA9TC79-1|A0AAA9TC79_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 49 OS=Bos taurus OX=9913 GN=ANKRD49 PE=4 SV=1 CANONICAL=Q5EA33-1" }, "locus": { "chromosome": "15", "start_pos": 1532269, "end_pos": 1524203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096277.1" } ] } }, { "isoform_ac": "Q5EA33-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA33/entry#Q5EA33-1", "sequence": { "sequence": "MEKEKVNDEKPDPENSLDFSEHFNQLELLETHGHLIPTGTQSLWIGNSDDDEEQDEKTEEWYQLQEKKMEKDPSKLLLWAAEKNRLTTVQRLLSERATHVNTRDEDKYTPLHRAAYNGHLDVVRELIAHGADVHAVTVDGWTPLHSACKWNNARVASFLLQHDADVNAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNSLEETAFDIARRTGIYHYLFEIVEGCTNCSPQS", "length": 238, "header": "sp|Q5EA33-1|ANR49_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 49 OS=Bos taurus OX=9913 GN=ANKRD49 PE=2 SV=1 CANONICAL=Q5EA33-1" }, "locus": { "chromosome": "15", "start_pos": 1525628, "end_pos": 1524203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048242.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048242.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045318.1", "url": "https://www.ensembl.org/id/ENSBTAP00000045318.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "site_lbl": "Ser48" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540949", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540949", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NYL1-1", "protein_name": "Ankyrin repeat domain 49", "gene_name": "ANKRD49", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSKGKRAAEKEADERDDDSDEFAEFTESFNQLELLETHRHLIPIGTQSCWSGQSDDEDDEQERSEEWYEMQEKKMEKNPEKLLLWAAENNRLTTVRRLLSEKLAPVNARDEDQYTPLHRASYSGHLDMARELVAQGADIHAQTVDGWTPLHSACKWNNTKVAAFLLQQGADINAQTNGLLTPLHIAAGNKNSRETLELLLMNRYIKADLKNNLDETAFDIARRTDIYHYLFEIVEDCINAVSP", "length": 243 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RCG8-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "ankrd49", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDFPEDFNQLELLDPHVIPMGTRSNWAEEEEGEEEDEAMHTEEWHQQQELHLQDTPSELMLWAAERNRCATVERLIALDPTLVNCHDSDGYTPLHRAAYSGHHDVASALLKAGANLHARTADDWMPLHSACRWGHANVASLLLQWGSEVNAMTAGRLTPLQLAAGNAAAGKTIELLLSQRTLEAGLKNSAGETAYDIAHRTSELHRLFEIVEPCNNVY", "length": 218 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1STJ8-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "ANKRD49", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKEKVNDDGKPDPEDSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDEKTEEWYQLQEKKMEQDPSKLLLWAAEKNRLSTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDVVRELIANGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNNLEETAFDIARRTSIHHYLFEIVEGCTNSSPQS", "length": 239 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HSN5-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "Ankrd49", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKEKVRDDEKPDPENSLDFSEEFNQLELLETHGHLIPTGTQSLWVGDSDEDEEQEEKQEEWYQLQEKKMEKDPSKLLLWAAEKNRLATVQRLLSEKATEVNTRDEDEYTPLHRAAYSGHLDIVRELVAHGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNNSQETAFDIARRTSIYHYLFEIVEGCTNSSPPS", "length": 239 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8VE42-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "Ankrd49", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKEKKDDEKPDLENSVDFSEQFNQLELLKTHGHLIPTGTQSLWVGNSDEDEEQEEKNEEWYQLQEKKMEKDPSKLLLWAAEKNRLATVQRLLSEKAAEVNTRDEDEYTPLHRAAYSGHIDVVRELVAKGADVHAVTVDGWTPLHSACKWNNTKVASFLLQHDADINAQTKGLLTPLHLAAGNRDSRDTLELLLMNRYIKPELKNNSQETASDIARRTSIYHYLFEIAEGCTNSSPPS", "length": 238 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WVL7-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "ANKRD49", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKEKGNDDGIPDQENSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTNSSPQS", "length": 239 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3Y0-1", "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "Ankrd49", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGDYDSDDEKSQVEKLRHAKVPRGMFVSGWDDDADELIEEDKNPQSSIERMILWAVNENRISEVREILKLDADTVNAKDNDGYTPLHRAAYNNFVDMAKLLLQYHANPNARTELGWTPLHSACKWNNADCAHLLLQFGADVNAESDGKQTPLHITATVSNCRNTATVLLLDRYIQPRKENNSEELASVIARRTGMSFPIFESGEEAYDCETGLID", "length": 215 }, "evidence": [ { "id": "Q5EA33", "url": "https://omabrowser.org/oma/group/Q5EA33/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q5EA33", "url": "https://www.uniprot.org/uniprotkb/Q5EA33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA33-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 238, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA33-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA33" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 48 ], "sequon_annotation_sites": [ { "start_pos": 233, "end_pos": 235 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA55-1", "uniprot_ac": "Q5EA55", "uniprot_id": "GOGA7_BOVIN", "mass": { "chemical_mass": 15824.0, "monoisotopic_mass": 15824.0 }, "refseq": { "ac": "NP_001030561", "name": "golgin subfamily A member 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030561" }, "gene_names": [ { "name": "GOLGA7", "type": "recommended", "evidence": [ { "id": "Q5EA55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ] }, { "name": "GOLGA7", "type": "synonym", "evidence": [ { "id": "NP_001030561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030561" } ] } ], "protein_names": [ { "name": "Golgin subfamily A member 7", "type": "recommended", "evidence": [ { "id": "Q5EA55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA55/entry#names_and_taxonomy" } ] }, { "name": "golgi autoantigen, golgin subfamily a, 7", "type": "synonym", "evidence": [ { "id": "NP_001030561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030561" } ] }, { "name": "golgin subfamily A member 7", "type": "synonym", "evidence": [ { "id": "NP_001030561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030561" } ] } ], "function": [ { "annotation": "May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55#function" }, { "database": "UniProtKB", "id": "A0AAA9TF57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF57#function" }, { "database": "UniProtKB", "id": "ARBA00037666", "url": "https://www.uniprot.org/uniprotkb/ARBA00037666#function" }, { "database": "UniProtKB", "id": "A0AAA9TSW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLGA7", "url": "https://www.uniprot.org/uniprotkb/Q5EA55", "locus": { "chromosome": "27", "start_pos": 36436491, "end_pos": 36419583, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027626", "url": "https://www.ensembl.org/id/ENSBTAG00000027626" } ] } } ], "crossref": [ { "id": "Q5EA55", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027626", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616809", "url": "https://www.ncbi.nlm.nih.gov/gene/616809", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616809", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616809", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEMRPQQ", "url": "https://omabrowser.org/oma/group/CEMRPQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA55", "url": "https://www.orthodb.org/?gene=Q5EA55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13254:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13254:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648002", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TF57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA55-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR", "length": 137, "header": "sp|Q5EA55-1|GOGA7_BOVIN Isoform 1 of Golgin subfamily A member 7 OS=Bos taurus OX=9913 GN=GOLGA7 PE=2 SV=1 CANONICAL=Q5EA55-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TF57-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA55/entry#A0AAA9TF57-1", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKPCRRVSRCPPGGNARAERSLALRFPALAGPEESLQIHSRAE", "length": 129, "header": "tr|A0AAA9TF57-1|A0AAA9TF57_BOVIN Computationally mapped isoform of Golgin subfamily A member 7 OS=Bos taurus OX=9913 GN=GOLGA7 PE=3 SV=1 CANONICAL=Q5EA55-1" }, "locus": { "chromosome": "27", "start_pos": 36431368, "end_pos": 36419876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128277.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128277.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095629.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095629.1" } ] } }, { "isoform_ac": "A0AAA9TSW5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA55/entry#A0AAA9TSW5-1", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVVSFQGS", "length": 128, "header": "tr|A0AAA9TSW5-1|A0AAA9TSW5_BOVIN Computationally mapped isoform of Golgin subfamily A member 7 OS=Bos taurus OX=9913 GN=GOLGA7 PE=3 SV=1 CANONICAL=Q5EA55-1" }, "locus": { "chromosome": "27", "start_pos": 36431854, "end_pos": 36419876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131903.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131903.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100436.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100436.1" } ] } }, { "isoform_ac": "A0AAF7AAZ6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA55/entry#A0AAF7AAZ6-1", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR", "length": 86, "header": "tr|A0AAF7AAZ6-1|A0AAF7AAZ6_BOVIN Computationally mapped isoform of Golgin A7 OS=Bos taurus OX=9913 GN=GOLGA7 PE=4 SV=1 CANONICAL=Q5EA55-1" }, "locus": { "chromosome": "27", "start_pos": 36432696, "end_pos": 36419876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069302.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069302.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066176.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066176.2" } ] } }, { "isoform_ac": "Q5EA55-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA55/entry#Q5EA55-1", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR", "length": 137, "header": "sp|Q5EA55-1|GOGA7_BOVIN Isoform 1 of Golgin subfamily A member 7 OS=Bos taurus OX=9913 GN=GOLGA7 PE=2 SV=1 CANONICAL=Q5EA55-1" }, "locus": { "chromosome": "27", "start_pos": 36432696, "end_pos": 36419876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039788.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039788.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039576.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039576.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616809", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616809", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-9648002", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648002", "resource": "Reactome", "description": "RAS processing" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U746-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGVSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MW90-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "Golga7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGVSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ZLC9-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSGGTRCQFQSKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKIAKFIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6AYQ1-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "Golga7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRVDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGVSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91W53-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "Golga7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGVSSGR", "length": 137 }, "evidence": [ { "id": "Q5EA55", "url": "https://omabrowser.org/oma/group/Q5EA55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" }, { "name": "palmitoyltransferase complex", "id": "GO:0002178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002178", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" }, { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "Q5EA55", "url": "https://www.uniprot.org/uniprotkb/Q5EA55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA55-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 137, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA55-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA55" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9V4-1", "uniprot_ac": "Q5E9V4", "uniprot_id": "MT25B_BOVIN", "mass": { "chemical_mass": 53207.0, "monoisotopic_mass": 53207.0 }, "refseq": { "ac": "NP_001015641", "name": "methyltransferase-like protein 25B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" }, "gene_names": [ { "name": "METTL25B", "type": "recommended", "evidence": [ { "id": "Q5E9V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ] }, { "name": "C1orf66", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "C3H1orf66", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "CGI-41", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "METTL25B", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "RRNAD1", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" }, { "id": "Q5E9V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ] } ], "protein_names": [ { "name": "Methyltransferase-like protein 25B", "type": "recommended", "evidence": [ { "id": "Q5E9V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4/entry#names_and_taxonomy" } ] }, { "name": "Protein RRNAD1", "type": "synonym", "evidence": [ { "id": "Q5E9V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4/entry#names_and_taxonomy" } ] }, { "name": "methyltransferase-like protein 25B", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "protein RRNAD1", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] }, { "name": "ribosomal RNA adenine dimethylase domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001015641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9V4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL25B", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4", "locus": { "chromosome": "3", "start_pos": 14098949, "end_pos": 14105919, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001519", "url": "https://www.ensembl.org/id/ENSBTAG00000001519" } ] } } ], "crossref": [ { "id": "Q5E9V4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9V4", "database": "AlphaFoldDB", "categories": [] }, { "id": "532204", "url": "https://www.ncbi.nlm.nih.gov/gene/532204", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020596", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020596", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532204", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532204", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9V4", "url": "https://www.orthodb.org/?gene=Q5E9V4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12496", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12496", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12496:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12496:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015641", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9V4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9V4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGVSARRLSHEERRQLAVNLTRVVTLYRSILDAYIIEFFTDNLWGTLPCSWQEALDGLNPPQLATLLLGMPREGEVARYRSVWPLTLLALKSTAYALAFTRTPGFQTPSEFLENPSQSSRLTAPFRKHVRPKKQHEIRRLGELVKKLSDLTGCTQVVDVGSGQGHLSRFMSLGLGLMVKSIEGDQRLVERAQRLDQELLQTLEKEEKRNPKVVQTGPRHPPHHVVRWVDPTTLCEELLLPLETSPQSRARLLLTGLHACGDLSVALLKHFCCCPEVVALASVGCCYMKLSDPGGYPLSQWVAGLPGYELPYRLREGACHALEEYAERLQKAGPSLRTHCYRAALETVIRCAQPELRRPGVQGIPRVHELKIEEYVQRGLQRVGLDPHLPLNVAALRAHQAQENRVVAFFSLALLLAPLVETLILLDRLLYLQEQGFHAELLPIFSPELSPRNLVLVATKGPLGEAFSLLETEDN", "length": 475, "header": "sp|Q5E9V4-1|MT25B_BOVIN Isoform 1 of Methyltransferase-like protein 25B OS=Bos taurus OX=9913 GN=METTL25B PE=2 SV=1 CANONICAL=Q5E9V4-1" }, "isoforms": [ { "isoform_ac": "Q5E9V4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4/entry#Q5E9V4-1", "sequence": { "sequence": "MPGVSARRLSHEERRQLAVNLTRVVTLYRSILDAYIIEFFTDNLWGTLPCSWQEALDGLNPPQLATLLLGMPREGEVARYRSVWPLTLLALKSTAYALAFTRTPGFQTPSEFLENPSQSSRLTAPFRKHVRPKKQHEIRRLGELVKKLSDLTGCTQVVDVGSGQGHLSRFMSLGLGLMVKSIEGDQRLVERAQRLDQELLQTLEKEEKRNPKVVQTGPRHPPHHVVRWVDPTTLCEELLLPLETSPQSRARLLLTGLHACGDLSVALLKHFCCCPEVVALASVGCCYMKLSDPGGYPLSQWVAGLPGYELPYRLREGACHALEEYAERLQKAGPSLRTHCYRAALETVIRCAQPELRRPGVQGIPRVHELKIEEYVQRGLQRVGLDPHLPLNVAALRAHQAQENRVVAFFSLALLLAPLVETLILLDRLLYLQEQGFHAELLPIFSPELSPRNLVLVATKGPLGEAFSLLETEDN", "length": 475, "header": "sp|Q5E9V4-1|MT25B_BOVIN Isoform 1 of Methyltransferase-like protein 25B OS=Bos taurus OX=9913 GN=METTL25B PE=2 SV=1 CANONICAL=Q5E9V4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532204", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532204", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "id": "GO:0000179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000179", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9V4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 475, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9V4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9V4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 20, "end_pos": 22 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9V5-1", "uniprot_ac": "Q5E9V5", "uniprot_id": "KLD8B_BOVIN", "mass": { "chemical_mass": 37540.0, "monoisotopic_mass": 37540.0 }, "refseq": { "ac": "NP_001030447", "name": "kelch domain-containing protein 8B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030447" }, "gene_names": [ { "name": "KLHDC8B", "type": "recommended", "evidence": [ { "id": "Q5E9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ] }, { "name": "KLHDC8B", "type": "synonym", "evidence": [ { "id": "NP_001030447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030447" } ] } ], "protein_names": [ { "name": "Kelch domain-containing protein 8B", "type": "recommended", "evidence": [ { "id": "Q5E9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5/entry#names_and_taxonomy" } ] }, { "name": "kelch domain-containing protein 8B", "type": "synonym", "evidence": [ { "id": "NP_001030447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030447" } ] } ], "function": [ { "annotation": "Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5#function" }, { "database": "UniProtKB", "id": "Q8IXV7", "url": "https://www.uniprot.org/uniprotkb/Q8IXV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHDC8B", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5", "locus": { "chromosome": "22", "start_pos": 50854958, "end_pos": 50859766, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000981", "url": "https://www.ensembl.org/id/ENSBTAG00000000981" } ] } } ], "crossref": [ { "id": "Q5E9V5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "527321", "url": "https://www.ncbi.nlm.nih.gov/gene/527321", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527321", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527321", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9V5", "url": "https://www.orthodb.org/?gene=Q5E9V5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46260:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46260:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030447", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9V5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATGGGRAFAWQVFPPMPTCRVYGTVAFQDGHLLVLGGCGRAGLPLDTAETLDMASHTWVALAPLPTARAGAAAVVLGKQVLVVGGVDEGQSPVAAVEAFLADEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGDHVVAIGGLGNQPCPLGSVEGFGLARRRWEALPAMPTARCSCSSLQAGPRLFAIGGVAQGPSQAVEALCLRDGV", "length": 354, "header": "sp|Q5E9V5-1|KLD8B_BOVIN Isoform 1 of Kelch domain-containing protein 8B OS=Bos taurus OX=9913 GN=KLHDC8B PE=2 SV=1 CANONICAL=Q5E9V5-1" }, "isoforms": [ { "isoform_ac": "Q5E9V5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5/entry#Q5E9V5-1", "sequence": { "sequence": "MATGGGRAFAWQVFPPMPTCRVYGTVAFQDGHLLVLGGCGRAGLPLDTAETLDMASHTWVALAPLPTARAGAAAVVLGKQVLVVGGVDEGQSPVAAVEAFLADEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGDHVVAIGGLGNQPCPLGSVEGFGLARRRWEALPAMPTARCSCSSLQAGPRLFAIGGVAQGPSQAVEALCLRDGV", "length": 354, "header": "sp|Q5E9V5-1|KLD8B_BOVIN Isoform 1 of Kelch domain-containing protein 8B OS=Bos taurus OX=9913 GN=KLHDC8B PE=2 SV=1 CANONICAL=Q5E9V5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 163, "start_aa": "Thr", "end_pos": 163, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:527321", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527321", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" }, { "name": "cellularization cleavage furrow", "id": "GO:0110070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110070", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitotic cytokinetic process", "id": "GO:1902410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902410", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" }, { "name": "mitotic nuclear division", "id": "GO:0140014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140014", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" }, { "name": "nuclear chromosome segregation", "id": "GO:0098813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098813", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V5", "url": "https://www.uniprot.org/uniprotkb/Q5E9V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9V5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9V5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9V5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 163 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9V6-1", "uniprot_ac": "Q5E9V6", "uniprot_id": "COMD4_BOVIN", "mass": { "chemical_mass": 21648.0, "monoisotopic_mass": 21648.0 }, "refseq": { "ac": "NP_001035687", "name": "COMM domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035687" }, "gene_names": [ { "name": "COMMD4", "type": "recommended", "evidence": [ { "id": "Q5E9V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ] }, { "name": "COMMD4", "type": "synonym", "evidence": [ { "id": "NP_001035687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035687" } ] } ], "protein_names": [ { "name": "COMM domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q5E9V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001035687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035687" } ] } ], "function": [ { "annotation": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Down-regulates activation of NF-kappa-B (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6#function" }, { "database": "UniProtKB", "id": "Q9H0A8", "url": "https://www.uniprot.org/uniprotkb/Q9H0A8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD4", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6", "locus": { "chromosome": "21", "start_pos": 33481858, "end_pos": 33487406, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007346", "url": "https://www.ensembl.org/id/ENSBTAG00000007346" } ] } } ], "crossref": [ { "id": "Q5E9V6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9V6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007346", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007346", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04752", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04752", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616960", "url": "https://www.ncbi.nlm.nih.gov/gene/616960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDCPDWL", "url": "https://omabrowser.org/oma/group/RDCPDWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX65", "url": "https://www.orthodb.org/?gene=A0A3Q1LX65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI87", "url": "https://www.orthodb.org/?gene=A0A3Q1MI87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9V6", "url": "https://www.orthodb.org/?gene=Q5E9V6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21672", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21672", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035687", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAI7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9V6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG", "length": 199, "header": "sp|Q5E9V6-1|COMD4_BOVIN Isoform 1 of COMM domain-containing protein 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=2 SV=2 CANONICAL=Q5E9V6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX65-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#A0A3Q1LX65-1", "sequence": { "sequence": "ILTTYLTLLQRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG", "length": 208, "header": "tr|A0A3Q1LX65-1|A0A3Q1LX65_BOVIN Computationally mapped isoform of COMM domain containing 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=4 SV=2 CANONICAL=Q5E9V6-1" }, "locus": { "chromosome": "21", "start_pos": 33484142, "end_pos": 33482095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083238.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083238.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062061.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062061.2" } ] } }, { "isoform_ac": "A0A3Q1MI87-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#A0A3Q1MI87-1", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKDLKQAQTLMSNVG", "length": 113, "header": "tr|A0A3Q1MI87-1|A0A3Q1MI87_BOVIN Computationally mapped isoform of COMM domain containing 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=4 SV=2 CANONICAL=Q5E9V6-1" }, "locus": { "chromosome": "21", "start_pos": 33487299, "end_pos": 33482095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087385.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087385.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074007.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074007.2" } ] } }, { "isoform_ac": "A0AAA9SVY0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#A0AAA9SVY0-1", "sequence": { "sequence": "MGNLPGPRSGHLGAVVKAEGLRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG", "length": 219, "header": "tr|A0AAA9SVY0-1|A0AAA9SVY0_BOVIN Computationally mapped isoform of COMM domain containing 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=4 SV=1 CANONICAL=Q5E9V6-1" }, "locus": { "chromosome": "21", "start_pos": 33487207, "end_pos": 33482095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096795.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096795.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088373.1" } ] } }, { "isoform_ac": "A0AAF6YQR0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#A0AAF6YQR0-1", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKIYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG", "length": 177, "header": "tr|A0AAF6YQR0-1|A0AAF6YQR0_BOVIN Computationally mapped isoform of COMM domain containing 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=4 SV=1 CANONICAL=Q5E9V6-1" }, "locus": { "chromosome": "21", "start_pos": 33487299, "end_pos": 33482095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009665.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009665.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009665.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009665.4" } ] } }, { "isoform_ac": "A0AAF6ZAI7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#A0AAF6ZAI7-1", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRDLKQAQTLMSNVG", "length": 140, "header": "tr|A0AAF6ZAI7-1|A0AAF6ZAI7_BOVIN Computationally mapped isoform of COMM domain containing 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=4 SV=1 CANONICAL=Q5E9V6-1" }, "locus": { "chromosome": "21", "start_pos": 33487299, "end_pos": 33482095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029872.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029872.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029868.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029868.5" } ] } }, { "isoform_ac": "Q5E9V6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6/entry#Q5E9V6-1", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG", "length": 199, "header": "sp|Q5E9V6-1|COMD4_BOVIN Isoform 1 of COMM domain-containing protein 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=2 SV=2 CANONICAL=Q5E9V6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616960", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FNB9-1", "protein_name": "COMM domain containing 4", "gene_name": "COMMD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKDLLGQGIDYEKILKLTADARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQEHLRACSLRVNRLAGVGWRVDYTVSSSLLYSVEEPMVHLRLEVAAAAGAPAQPVAMSLSADKFQVLLAELKQAQALMSSLG", "length": 199 }, "evidence": [ { "id": "Q5E9V6", "url": "https://omabrowser.org/oma/group/Q5E9V6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1Q509-1", "protein_name": "COMM domain-containing protein 4", "gene_name": "commd4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLARISSVKMKLLCVQVVKDLLDEGIDYDKVSKLTSDAKFDSGDIKACIGVLSFILSSAAKHDVDSESLSSELQQLGLPKEHTTGLCKSYEDKHSALQEKLRESSLRLGRLQTVNWRVDYTLSSSELKQVNEPTVQLRLQAQDPLTDSSETTVVSITADKFRVLLTELKQAQNMMNVLQ", "length": 199 }, "evidence": [ { "id": "Q5E9V6", "url": "https://omabrowser.org/oma/group/Q5E9V6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q550I8-1", "protein_name": "COMM domain-containing protein 4", "gene_name": "commd4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTNIRIKLLTVQVITSLASGENIDFEKVEKLVKDAGFVIGDIKALIAAIHFIIFNSVKNDVDESTLSTELQQLGLPKEHCDSISRAFREHKEKLRSIFHNNTLKLPSLHSLDWRVDFILSSNTIQEVNSPSVQLNFKVKNHSNNEITNHPFEISAKKFNVLYYELKGAKLLMETVNQ", "length": 177 }, "evidence": [ { "id": "Q5E9V6", "url": "https://omabrowser.org/oma/group/Q5E9V6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CQ02-1", "protein_name": "COMM domain-containing protein 4", "gene_name": "Commd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKEHATSLCRCYEEKQSPLQEHLRACSLRVNRLASVGWRVDYTLSSSLLHSVEEPMVHLQLQVVPAPGTQAQPVSMSLSADKFQVLLAELKQAQTMMTALG", "length": 199 }, "evidence": [ { "id": "Q5E9V6", "url": "https://omabrowser.org/oma/group/Q5E9V6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0A8-1", "protein_name": "COMM domain-containing protein 4", "gene_name": "COMMD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG", "length": 199 }, "evidence": [ { "id": "Q5E9V6", "url": "https://omabrowser.org/oma/group/Q5E9V6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V6", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9V6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 199, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9V6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9V6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9V6" }, { "id": "PRU00602", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00602" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000255", "start_pos": 130, "end_pos": 199, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9X7-1", "uniprot_ac": "Q5E9X7", "uniprot_id": "PRS35_BOVIN", "mass": { "chemical_mass": 46537.0, "monoisotopic_mass": 46537.0 }, "refseq": { "ac": "NP_001030534", "name": "inactive serine protease 35 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534" }, "gene_names": [ { "name": "PRSS35", "type": "recommended", "evidence": [ { "id": "Q5E9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7" } ] }, { "name": "PRSS35", "type": "synonym", "evidence": [ { "id": "NP_001030534", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534" } ] } ], "protein_names": [ { "name": "Inactive serine protease 35", "type": "recommended", "evidence": [ { "id": "Q5E9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7/entry#names_and_taxonomy" } ] }, { "name": "inactive serine protease 35 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030534", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534" } ] }, { "name": "inactive serine protease 35", "type": "synonym", "evidence": [ { "id": "NP_001030534", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534" } ] }, { "name": "protease, serine 35", "type": "synonym", "evidence": [ { "id": "NP_001030534", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9X7", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRSS35", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7", "locus": { "chromosome": "9", "start_pos": 23459862, "end_pos": 23439524, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052055", "url": "https://www.ensembl.org/id/ENSBTAG00000052055" } ] } } ], "crossref": [ { "id": "Q5E9X7", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052055", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614940", "url": "https://www.ncbi.nlm.nih.gov/gene/614940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614940", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614940", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEQDFMW", "url": "https://omabrowser.org/oma/group/MEQDFMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9X7", "url": "https://www.orthodb.org/?gene=Q5E9X7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15462:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15462:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030534", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9X7", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAMFFGLMLFTLGWTLIDGSESEQDFMWHVRKIPRLVSERTFHLTSPAFEADAKMVLNRVCGIECQKDLPAPSLSDLEDSLSYETVFENGSRTLTRVKVQGWVPEPTQNLTSQGAPVRRKRQVYGTDSRFSILDKKFLTNFPFNTAVKLSTGCSGILISPNHVLTAAHCVHDGNGYIKGSKKLRVGLLKMRNKGGGKRRRGSRRNRREVSGAGREGSQDSLKETAKAGRRRKGSARRQRAADGRPSFQWTRVKNTHIPKGWARGESRDPALDYDYALLELKRPHKKKYMELGVSPTIKKLPGGMIHFSGFDQDRADQLVYRFCSVSDESNDLLYQYCDAESGSTGSGVYLRLKEPDKKRWKRKIIAIYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWMHGDDANCTQG", "length": 412, "header": "sp|Q5E9X7-1|PRS35_BOVIN Isoform 1 of Inactive serine protease 35 OS=Bos taurus OX=9913 GN=PRSS35 PE=2 SV=2 CANONICAL=Q5E9X7-1" }, "isoforms": [ { "isoform_ac": "Q5E9X7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7/entry#Q5E9X7-1", "sequence": { "sequence": "MGAMFFGLMLFTLGWTLIDGSESEQDFMWHVRKIPRLVSERTFHLTSPAFEADAKMVLNRVCGIECQKDLPAPSLSDLEDSLSYETVFENGSRTLTRVKVQGWVPEPTQNLTSQGAPVRRKRQVYGTDSRFSILDKKFLTNFPFNTAVKLSTGCSGILISPNHVLTAAHCVHDGNGYIKGSKKLRVGLLKMRNKGGGKRRRGSRRNRREVSGAGREGSQDSLKETAKAGRRRKGSARRQRAADGRPSFQWTRVKNTHIPKGWARGESRDPALDYDYALLELKRPHKKKYMELGVSPTIKKLPGGMIHFSGFDQDRADQLVYRFCSVSDESNDLLYQYCDAESGSTGSGVYLRLKEPDKKRWKRKIIAIYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWMHGDDANCTQG", "length": 412, "header": "sp|Q5E9X7-1|PRS35_BOVIN Isoform 1 of Inactive serine protease 35 OS=Bos taurus OX=9913 GN=PRSS35 PE=2 SV=2 CANONICAL=Q5E9X7-1" }, "locus": { "chromosome": "9", "start_pos": 23457472, "end_pos": 23456237, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068329.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068329.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069102.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "Q5E9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X7", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614940", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614940", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RQM7-1", "protein_name": "Inactive serine protease 35", "gene_name": "PRSS35", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAMLFWWIFFTLGWTLIDGSEMEQDFMWHLRKIPRVVDERTFHLTSPTFEADAKMALNGVCGIECQKELPSPSLSDLEDSLSYETVFENGTRTLTRVKVQGWVPEPTQNLTNQGVPIRRKRQVYGTDSRFSILDKRFLTNFPFNTAVKLSTGCSGVLISPNHVLTAAHCVHDGKDYIKGTKKLRVGLLKMRNKGGGKKRRRGSRRSRREVSGDDGGKESKENLKESAKAGRRRNKSARGQRTAAGEPSFQWTRVKHTHIPKGWVRGESGDAALDYDYALLELKRSHKKKYMELGISPTIKKLPSGMIHFSGFDHDRADQLVYRFCSVSDESSDLLYQYCDAESGSTGSGVYLRLKEPGKKSWKRKIIAVYSGHQWVDVHGVEKDYNVAVRITPLKYAQICLWMHGDDANCTYG", "length": 414 }, "evidence": [ { "id": "Q5E9X7", "url": "https://omabrowser.org/oma/group/Q5E9X7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5R212-1", "protein_name": "Inactive serine protease 35", "gene_name": "Prss35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLWLIIFVSGWTLSLGSETEPDFTWHLSRIPQVVSEKTIHLASPTFQADAAAVKATVCGIECQEELPAPSLSQLEDFLSYETVFENGTRTLTRVKVQGLVLEPTQNSSIKGARPRRRRQVYGTDSRFSILDKRFLTNFPFNTAVKLSTGCSGALVSPNHVLTAAHCVHDGKDYVKGSKKLRVGVLKMRNKGGRKKRRGSRRSRREAESGGQSPEHPQESTTQRPGKKSRRGPRVAQGRPSFQWTRVKSTHIPKGWARGENGDPALDFDYALLELKRAQKQQYMELGVSPTISKLPGGRIHFSGFDNDRDDQLVYRFCSVSEESNDLLYQYCDAEAGSTGSGIYLRLKEPGQKNWKRKIIAVYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWIHGNAANCAYG", "length": 406 }, "evidence": [ { "id": "Q5E9X7", "url": "https://omabrowser.org/oma/group/Q5E9X7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C0F9-1", "protein_name": "Inactive serine protease 35", "gene_name": "Prss35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENTLLWLVILIPGWALSDGSETELDFTWHLSRIPQVVSENTIHLASPTFQADAGVVKATVCGIECQEELPAPSLSQLEESLSYETIFENGTRTLTRVKVQGLVLEPTRNSSVKGAHPRRRRQVYGTDSRFSILDKRFATNFPFNTAVKLSTGCSGTLVSPNHVLTAAHCVHDGKDYVKGSKKLRVGVLKMRNKGGRKKRRGSKRSRREAESAGQSQAHLRESTTQRPGKKSRRGPRVTQGRPSFQWTRVKSTHIPKGWVRGENGGLALDYDYALLELKRAHKQQHMELGVSPTITKLPGGRIHFSGFDNDRDEQLVYRFCSVSEESNDLLYQYCDAEAGSTGSGIYLRLKEPGQKNWKRKIVAVYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWIHGNAANCAYG", "length": 409 }, "evidence": [ { "id": "Q5E9X7", "url": "https://omabrowser.org/oma/group/Q5E9X7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N3Z0-1", "protein_name": "Inactive serine protease 35", "gene_name": "PRSS35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENMLLWLIFFTPGWTLIDGSEMEWDFMWHLRKVPRIVSERTFHLTSPAFEADAKMMVNTVCGIECQKELPTPSLSELEDYLSYETVFENGTRTLTRVKVQDLVLEPTQNITTKGVSVRRKRQVYGTDSRFSILDKRFLTNFPFSTAVKLSTGCSGILISPQHVLTAAHCVHDGKDYVKGSKKLRVGLLKMRNKSGGKKRRGSKRSRREASGGDQREGTREHLRERAKGGRRRKKSGRGQRIAEGRPSFQWTRVKNTHIPKGWARGGMGDATLDYDYALLELKRAHKKKYMELGISPTIKKMPGGMIHFSGFDNDRADQLVYRFCSVSDESNDLLYQYCDAESGSTGSGVYLRLKDPDKKNWKRKIIAVYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWIHGNDANCAYG", "length": 413 }, "evidence": [ { "id": "Q5E9X7", "url": "https://omabrowser.org/oma/group/Q5E9X7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X7", "url": "https://www.uniprot.org/uniprotkb/Q5E9X7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9X7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 412, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9X7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9X7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 110 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9X8-1", "uniprot_ac": "Q5E9X8", "uniprot_id": "RAD9B_BOVIN", "mass": { "chemical_mass": 49346.0, "monoisotopic_mass": 49346.0 }, "refseq": { "ac": "NP_001030556", "name": "cell cycle checkpoint control protein RAD9B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" }, "gene_names": [ { "name": "RAD9B", "type": "recommended", "evidence": [ { "id": "Q5E9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ] }, { "name": "RAD9B", "type": "synonym", "evidence": [ { "id": "NP_001030556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" } ] } ], "protein_names": [ { "name": "Cell cycle checkpoint control protein RAD9B", "type": "recommended", "evidence": [ { "id": "Q5E9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8/entry#names_and_taxonomy" } ] }, { "name": "DNA repair exonuclease rad9 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001030556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" }, { "id": "Q5E9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8/entry#names_and_taxonomy" } ] }, { "name": "RAD9 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001030556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" } ] }, { "name": "cell cycle checkpoint control protein RAD9B homolog", "type": "synonym", "evidence": [ { "id": "NP_001030556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" } ] }, { "name": "cell cycle checkpoint control protein RAD9B", "type": "synonym", "evidence": [ { "id": "NP_001030556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAD9B", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8", "locus": { "chromosome": "17", "start_pos": 54406455, "end_pos": 54377483, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018330", "url": "https://www.ensembl.org/id/ENSBTAG00000018330" } ] } } ], "crossref": [ { "id": "Q5E9X8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00577", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00577", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616597", "url": "https://www.ncbi.nlm.nih.gov/gene/616597", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616597", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616597", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9X8", "url": "https://www.orthodb.org/?gene=Q5E9X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15237:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15237:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04139", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04139", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030556", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAHLLLFMRIIYIHRCPLNEVAPPGQVVEVFGKAIQALSRVSDELWLDPSEKGLALRSVNSCRSAYGCVLFSPVFFQHYQWSASVKMNDTDIILNLNCRLGMKSILPIFRCLNSLEKNVEKCKIFTRSDKCKVVIQFFCRHGIKKIHNVCFQGSRPLQVIFQKNMCANTLVIQPRVLAEAIVLFTSSQEEVTLAVTPLKVCIKSSNEESMDLTDSVYSEMFVGPDEFDFFQIGIDTEITFCFKELKGVLTFSEAIHAPIAIHFDFPGKPMALSIDDMLLEANFILATLADEPSRASSLQTLYLSQKQRRSEPIHSNSKAGKNITSKVPEYISRKVEPKRLYSNETPTNISTLENCGSPLMKRANKDITEVPESDGNLSEVPESSVSDTEDVPGSPCLKKFSCMFFGAASSDQQEPFSLPFQSLATASGSEEDMNNGSFSTF", "length": 442, "header": "sp|Q5E9X8-1|RAD9B_BOVIN Isoform 1 of Cell cycle checkpoint control protein RAD9B OS=Bos taurus OX=9913 GN=RAD9B PE=2 SV=1 CANONICAL=Q5E9X8-1" }, "isoforms": [ { "isoform_ac": "Q5E9X8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8/entry#Q5E9X8-1", "sequence": { "sequence": "MKAHLLLFMRIIYIHRCPLNEVAPPGQVVEVFGKAIQALSRVSDELWLDPSEKGLALRSVNSCRSAYGCVLFSPVFFQHYQWSASVKMNDTDIILNLNCRLGMKSILPIFRCLNSLEKNVEKCKIFTRSDKCKVVIQFFCRHGIKKIHNVCFQGSRPLQVIFQKNMCANTLVIQPRVLAEAIVLFTSSQEEVTLAVTPLKVCIKSSNEESMDLTDSVYSEMFVGPDEFDFFQIGIDTEITFCFKELKGVLTFSEAIHAPIAIHFDFPGKPMALSIDDMLLEANFILATLADEPSRASSLQTLYLSQKQRRSEPIHSNSKAGKNITSKVPEYISRKVEPKRLYSNETPTNISTLENCGSPLMKRANKDITEVPESDGNLSEVPESSVSDTEDVPGSPCLKKFSCMFFGAASSDQQEPFSLPFQSLATASGSEEDMNNGSFSTF", "length": 442, "header": "sp|Q5E9X8-1|RAD9B_BOVIN Isoform 1 of Cell cycle checkpoint control protein RAD9B OS=Bos taurus OX=9913 GN=RAD9B PE=2 SV=1 CANONICAL=Q5E9X8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 387, "end_pos": 387, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "site_lbl": "Ser387" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616597", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616597", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA replication checkpoint signaling", "id": "GO:0000076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000076", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "pmid": "" }, { "name": "mitotic intra-S DNA damage checkpoint signaling", "id": "GO:0031573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031573", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "checkpoint clamp complex", "id": "GO:0030896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030896", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X8", "url": "https://www.uniprot.org/uniprotkb/Q5E9X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9X8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 442, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9X8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9X8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 387 ], "sequon_annotation_sites": [ { "start_pos": 323, "end_pos": 325 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9Z5-1", "uniprot_ac": "Q5E9Z5", "uniprot_id": "CXB6_BOVIN", "mass": { "chemical_mass": 30229.0, "monoisotopic_mass": 30229.0 }, "refseq": { "ac": "NP_001015546", "name": "gap junction beta-6 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" }, "gene_names": [ { "name": "GJB6", "type": "recommended", "evidence": [ { "id": "Q5E9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ] }, { "name": "CXNF", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] }, { "name": "GJB6", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] } ], "protein_names": [ { "name": "Gap junction beta-6 protein", "type": "recommended", "evidence": [ { "id": "Q5E9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5/entry#names_and_taxonomy" } ] }, { "name": "connexin F", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] }, { "name": "gap junction beta-6 protein", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] }, { "name": "gap junction protein, beta 6 (connexin 30)", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] }, { "name": "gap junction protein, beta 6, 30kDa", "type": "synonym", "evidence": [ { "id": "NP_001015546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546" } ] } ], "function": [ { "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GJB6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5", "locus": { "chromosome": "12", "start_pos": 36060114, "end_pos": 36051453, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038662", "url": "https://www.ensembl.org/id/ENSBTAG00000038662" } ] } } ], "crossref": [ { "id": "Q5E9Z5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038662", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038662", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508454", "url": "https://www.ncbi.nlm.nih.gov/gene/508454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508454", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508454", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PNHAIKE", "url": "https://omabrowser.org/oma/group/PNHAIKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9Z5", "url": "https://www.orthodb.org/?gene=Q5E9Z5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015546", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Z5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWGTLHTFVGGVNKHSTSIGKVWVTVLFVFRVMILVVAAQEVWGDEQEDFVCNTLQPGCRNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHEAARRFRRGETRSEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIVFEAAFMYVFYFLYNGYHLPWVLKCGIQPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSKRAQTQKAPPNHALKESKQNEMNELISEGGQNAITGFPS", "length": 261, "header": "sp|Q5E9Z5-1|CXB6_BOVIN Isoform 1 of Gap junction beta-6 protein OS=Bos taurus OX=9913 GN=GJB6 PE=2 SV=1 CANONICAL=Q5E9Z5-1" }, "isoforms": [ { "isoform_ac": "Q5E9Z5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5/entry#Q5E9Z5-1", "sequence": { "sequence": "MDWGTLHTFVGGVNKHSTSIGKVWVTVLFVFRVMILVVAAQEVWGDEQEDFVCNTLQPGCRNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHEAARRFRRGETRSEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIVFEAAFMYVFYFLYNGYHLPWVLKCGIQPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSKRAQTQKAPPNHALKESKQNEMNELISEGGQNAITGFPS", "length": 261, "header": "sp|Q5E9Z5-1|CXB6_BOVIN Isoform 1 of Gap junction beta-6 protein OS=Bos taurus OX=9913 GN=GJB6 PE=2 SV=1 CANONICAL=Q5E9Z5-1" }, "locus": { "chromosome": "12", "start_pos": 36059371, "end_pos": 36058589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110243.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110243.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082745.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508454", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508454", "resource": "KEGG Pathway" }, { "id": "R-BTA-190861", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZY70-1", "protein_name": "Gap junction protein", "gene_name": "GJB6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDWGALQTILGGVNKHSTSIGKIWLTVLFIFRVMILVVAAKEVWGDEQEDFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYYRHEAARRFRRGETRSEFKDLEDIKQRKVRIEGSLWWTYTGSIFFRILFEAAFMYVFYFLYNGYHLPWVLKCGIAPCPNLVDCFISRPTEKTVFTVFMVAASVLCVLLNVAELCYLLLKVCCRRAGRAQAPRDLPGPALKERRQNEANELLSEGGPNALPGLPG", "length": 261 }, "evidence": [ { "id": "Q5E9Z5", "url": "https://omabrowser.org/oma/group/Q5E9Z5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95452-1", "protein_name": "Gap junction beta-6 protein", "gene_name": "GJB6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDIKKQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSKRAQTQKNHPNHALKESKQNEMNELISDSGQNAITGFPS", "length": 261 }, "evidence": [ { "id": "Q5E9Z5", "url": "https://omabrowser.org/oma/group/Q5E9Z5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P70689-1", "protein_name": "Gap junction beta-6 protein", "gene_name": "Gjb6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETARKFIRGEKRNEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLCFRRSKRTQAQRNHPNHALKESKQNEMNELISDSGQNAITSFPS", "length": 261 }, "evidence": [ { "id": "Q5E9Z5", "url": "https://omabrowser.org/oma/group/Q5E9Z5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AZ42-1", "protein_name": "Gap junction protein", "gene_name": "Gjb6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETARKFIRGEKRNEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLCFRRSKRTQAQRNHPNHALKESKQNEMNELISDSGQNAITSFPS", "length": 261 }, "evidence": [ { "id": "Q5E9Z5", "url": "https://omabrowser.org/oma/group/Q5E9Z5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TSX0-1", "protein_name": "Gap junction protein", "gene_name": "Gjb6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETARKFIRGEKRNEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIEPCPNLVDCFISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLCFRRSKRTQAQRNHPNHALKESKQNEINELISDSGQNAITSFPS", "length": 261 }, "evidence": [ { "id": "Q5E9Z5", "url": "https://omabrowser.org/oma/group/Q5E9Z5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "gap junction assembly", "id": "GO:0016264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016264", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "gap junction-mediated intercellular transport", "id": "GO:1990349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990349", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "beta-tubulin binding", "id": "GO:0048487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "gap junction channel activity involved in cell communication by electrical coupling", "id": "GO:1903763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903763", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" }, { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z5", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Z5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA03-1", "uniprot_ac": "Q5EA03", "uniprot_id": "TM186_BOVIN", "mass": { "chemical_mass": 23785.0, "monoisotopic_mass": 23785.0 }, "refseq": { "ac": "NP_001014919", "name": "transmembrane protein 186", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014919" }, "gene_names": [ { "name": "TMEM186", "type": "recommended", "evidence": [ { "id": "Q5EA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ] }, { "name": "TMEM186", "type": "synonym", "evidence": [ { "id": "NP_001014919", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014919" } ] } ], "protein_names": [ { "name": "Transmembrane protein 186", "type": "recommended", "evidence": [ { "id": "Q5EA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA03/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 186", "type": "synonym", "evidence": [ { "id": "NP_001014919", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014919" } ] } ], "function": [ { "annotation": "As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03#function" }, { "database": "UniProtKB", "id": "Q96B77", "url": "https://www.uniprot.org/uniprotkb/Q96B77#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM186", "url": "https://www.uniprot.org/uniprotkb/Q5EA03", "locus": { "chromosome": "25", "start_pos": 7650091, "end_pos": 7652689, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022530", "url": "https://www.ensembl.org/id/ENSBTAG00000022530" } ] } } ], "crossref": [ { "id": "Q5EA03", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA03", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022530", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022530", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513552", "url": "https://www.ncbi.nlm.nih.gov/gene/513552", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513552", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513552", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTIGDTG", "url": "https://omabrowser.org/oma/group/MTIGDTG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA03", "url": "https://www.orthodb.org/?gene=Q5EA03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13603:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13603:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014919", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA03-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVLRAVARSPGPAAWGRPLHRLCCCGGQDPRRWVGSGPPHSKEKPLGPETEKFQMVYRFDAIKAFGYLSRLKVAQTALTVAALPPGLYCYSQGLMPFSSLCLAGGVAGFALAMLCWMSHFFRRLVGILYVNEEGTVLRVAHLTFWGRRQDTYCPVADVIPMTESPDRPQELFMRIQQYSGKQTFYLTLRYGRVLDQERFTQVFGVLDALK", "length": 212, "header": "sp|Q5EA03-1|TM186_BOVIN Isoform 1 of Transmembrane protein 186 OS=Bos taurus OX=9913 GN=TMEM186 PE=2 SV=1 CANONICAL=Q5EA03-1" }, "isoforms": [ { "isoform_ac": "Q5EA03-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA03/entry#Q5EA03-1", "sequence": { "sequence": "MAAVLRAVARSPGPAAWGRPLHRLCCCGGQDPRRWVGSGPPHSKEKPLGPETEKFQMVYRFDAIKAFGYLSRLKVAQTALTVAALPPGLYCYSQGLMPFSSLCLAGGVAGFALAMLCWMSHFFRRLVGILYVNEEGTVLRVAHLTFWGRRQDTYCPVADVIPMTESPDRPQELFMRIQQYSGKQTFYLTLRYGRVLDQERFTQVFGVLDALK", "length": 212, "header": "sp|Q5EA03-1|TM186_BOVIN Isoform 1 of Transmembrane protein 186 OS=Bos taurus OX=9913 GN=TMEM186 PE=2 SV=1 CANONICAL=Q5EA03-1" }, "locus": { "chromosome": "25", "start_pos": 7652660, "end_pos": 7650886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030501.3", "url": "https://www.ensembl.org/id/ENSBTAT00000030501.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030481.2", "url": "https://www.ensembl.org/id/ENSBTAP00000030481.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513552", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513552", "resource": "KEGG Pathway" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AQT2-1", "protein_name": "Transmembrane protein 186", "gene_name": "TMEM186", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALLRAVLWSPRQAAWGRPFHRLWRCSGQDPRRWAGSRPLPSKKNPLGTETEKFQMVYRFDAIRVFGYLSQLKVAQTALTVVALPPGIYWYSQGLMTFNSLCLAGAVASFALAMLCWMSHFFRRLVGILYVNESGTVLRVAHLTFWGRRQDTYCPVADVVPMTESHDRPQELFVRIRQYSGKQTFYLTLRYGRILDRERFMQVFGALDSLK", "length": 212 }, "evidence": [ { "id": "Q5EA03", "url": "https://omabrowser.org/oma/group/Q5EA03/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YTP7-1", "protein_name": "Transmembrane protein 186", "gene_name": "TMEM186", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "ALRSVCPQVRLCCVRSGRAAPSPWRCLRGEPWRRAWKKEAAGPPGTSVWLRPPDGRIHGAPADGETRCVPCRQLRRWAPAAAGPQKAADGTSEEFSVVYRFPGIKYCRVLSRLKLLQTATTLLVLPPVCYLHLQQQLPQAVLLYTAGIALFAAVMLYGMSYFFRRIIGLIYLSESGRTVKVAHLTFWGSRKDIYCPLETVMTLDEVGDARGELLLRFRRYNSTEILYFTIKYGQIVDRQKFMQIFGELQ", "length": 249 }, "evidence": [ { "id": "Q5EA03", "url": "https://omabrowser.org/oma/group/Q5EA03/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q4KLZ1-1", "protein_name": "Transmembrane protein 186", "gene_name": "Tmem186", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFLLRAVPRLQGPAAWRRPLQQLWCRAGQGDSIRWVGSRSPPSQEKPPGTETEKFHTIYRFNAIRALGFLSRLKLAQTAVTVVALPPGFYCYSQGLMTLSSLGLMSGIASFALVMLCWMSHFFRRLVGILYVNESGTLLRVAHLTFWGWRQDTYCAVSDMIPLSESEERVQDVFVRIQQYSGKQTFYLTLRYGRILDRDRFSQVFGTLATLKNSK", "length": 216 }, "evidence": [ { "id": "Q5EA03", "url": "https://omabrowser.org/oma/group/Q5EA03/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96B77-1", "protein_name": "Transmembrane protein 186", "gene_name": "TMEM186", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALLRAVRRFRGKAVWERPLHGLWCCSGQEDPKRWVGSSSPISKEKLPNAETEKFWMFYRFDAIRTFGFLSRLKLAQTALTVVALPPGYYLYSQGLLTLNTVCLMSGISGFALTMLCWMSYFLRRLVGILYLNESGTMLRVAHLNFWGWRQDTYCPMADVIPLTETKDRPQEMFVRIQRYSGKQTFYVTLRYGRILDRERFTQVFGVHQMLK", "length": 213 }, "evidence": [ { "id": "Q5EA03", "url": "https://omabrowser.org/oma/group/Q5EA03/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR76-1", "protein_name": "Transmembrane protein 186", "gene_name": "Tmem186", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLLRVVPRLQGPTAWRRPLQGLWCCSGQGDSKRWVGSRSPHSREKSPGTETETFHTIYRFRAIRAIGFLSRLKLAQTAVTVVALPPGFYCYSQGLMTLSSLCLLGGVASFALAMLCWMSHFFRRLVGILYVNESGTLLRVAHLTFWGWRQDTYCAVSDMIPLSESQERVQDVFVRIQQYSGKQTFYLTLRYGRILDRERFAQVFGTLATLKNSK", "length": 216 }, "evidence": [ { "id": "Q5EA03", "url": "https://omabrowser.org/oma/group/Q5EA03/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ], "pmid": "" }, { "name": "mitochondrial complex I intermediate assembly complex", "id": "GO:0160295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160295", "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q5EA03", "url": "https://www.uniprot.org/uniprotkb/Q5EA03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA03-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA03-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA03" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA18-1", "uniprot_ac": "Q5EA18", "uniprot_id": "CENPL_BOVIN", "mass": { "chemical_mass": 39422.0, "monoisotopic_mass": 39422.0 }, "refseq": { "ac": "NP_001029954", "name": "centromere protein L", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954" }, "gene_names": [ { "name": "CENPL", "type": "recommended", "evidence": [ { "id": "Q5EA18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ] }, { "name": "CENPL", "type": "synonym", "evidence": [ { "id": "NP_001029954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954" } ] }, { "name": "DJ383J4.3", "type": "synonym", "evidence": [ { "id": "NP_001029954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954" } ] } ], "protein_names": [ { "name": "Centromere protein L", "type": "recommended", "evidence": [ { "id": "Q5EA18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA18/entry#names_and_taxonomy" } ] }, { "name": "CENP-L", "type": "synonym", "evidence": [ { "id": "NP_001029954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954" }, { "id": "Q5EA18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA18/entry#names_and_taxonomy" } ] }, { "name": "centromere protein L", "type": "synonym", "evidence": [ { "id": "NP_001029954", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954" } ] } ], "function": [ { "annotation": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPL", "url": "https://www.uniprot.org/uniprotkb/Q5EA18", "locus": { "chromosome": "16", "start_pos": 55179707, "end_pos": 55203940, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006925", "url": "https://www.ensembl.org/id/ENSBTAG00000006925" } ] } } ], "crossref": [ { "id": "Q5EA18", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA18", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006925", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006925", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615527", "url": "https://www.ncbi.nlm.nih.gov/gene/615527", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615527", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615527", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TACKMDQ", "url": "https://omabrowser.org/oma/group/TACKMDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA18", "url": "https://www.orthodb.org/?gene=Q5EA18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31740:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31740:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029954", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA18-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSYDAPELTPRQDASSRLKDFFVGATPLQKRLESVRKQTSFIPTPPRRKIPQGSQLQEDVDPQKFAFLLHKQWTLYSLTPLYKFSYTNFKEYSKLLNAFIAAEKQKGLAVEVGDDFNIKVVFSTLMGVKGTQRDPEAFLVQILSKSQLPSEHKEGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLVNGAETNTAIIGTWFQKTFDCYFRPLAINAFNLSWMAAMWTACKMDHYMATTEFLWSVPCSPHSLDISYAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCPKYLIGVLAYLTELAVFQIE", "length": 346, "header": "sp|Q5EA18-1|CENPL_BOVIN Isoform 1 of Centromere protein L OS=Bos taurus OX=9913 GN=CENPL PE=2 SV=1 CANONICAL=Q5EA18-1" }, "isoforms": [ { "isoform_ac": "Q5EA18-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA18/entry#Q5EA18-1", "sequence": { "sequence": "MDSYDAPELTPRQDASSRLKDFFVGATPLQKRLESVRKQTSFIPTPPRRKIPQGSQLQEDVDPQKFAFLLHKQWTLYSLTPLYKFSYTNFKEYSKLLNAFIAAEKQKGLAVEVGDDFNIKVVFSTLMGVKGTQRDPEAFLVQILSKSQLPSEHKEGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLVNGAETNTAIIGTWFQKTFDCYFRPLAINAFNLSWMAAMWTACKMDHYMATTEFLWSVPCSPHSLDISYAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCPKYLIGVLAYLTELAVFQIE", "length": 346, "header": "sp|Q5EA18-1|CENPL_BOVIN Isoform 1 of Centromere protein L OS=Bos taurus OX=9913 GN=CENPL PE=2 SV=1 CANONICAL=Q5EA18-1" }, "locus": { "chromosome": "16", "start_pos": 55194011, "end_pos": 55180235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009094.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009094.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009094.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009094.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 41, "end_pos": 41, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "site_lbl": "Ser41" }, { "start_pos": 45, "end_pos": 45, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "site_lbl": "Thr45" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "site_lbl": "Ser55" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615527", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615527", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-606279", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GZL1-1", "protein_name": "Centromere protein L", "gene_name": "Cenpl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPYDSQGSTSRRRTSNLKDYFVGATPLQKRLESIRRQSSFFPSPPRRKIPQGTELQEEIDPQKVGFLLHKQWTVYSLTPLYKFSYTNFKEYSRLLSAFIAAEKQKGLAVQVGEDFNIKVIFSNLVGVRGTQRDPEAFLVQILSKSQSSREHREGRVLWTGWFCCVFGESLLETVSEDFTCLPLFLANGAESNTSLIGGWFQKTFDCCFSPLAISAFHLSWMAAMWTACEMDHYMATTEFFWSVPCSPQSLDISYAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFRIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYMTELAIFKTE", "length": 345 }, "evidence": [ { "id": "Q5EA18", "url": "https://omabrowser.org/oma/group/Q5EA18/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1T7C0-1", "protein_name": "Centromere protein L", "gene_name": "CENPL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGGRPAGSAIEMEGAMRTLPSSGRPSGTGWQSRGPLFGRNYGLSPGSRLLPPRCQENADPQKMAFLLRKQWTLYSVSPLYKFSSADLKDYARMLGVFIAAEKQKGLAVDVDGELGIKVAMSGLPELRGSEQDPAAVLVQLSLRSSVSPKNSEEKLIWSGWFCCVAGDDLLENLPENFTCLPLFLVNGAESYTAIVGSWFQKTFDCCFRRLAISPLNLTWMAAMWTGCKVDKNTAATELLFSVPHLPQPLDISYAIHPEDAKALWDTVQKTPGEITQEEVDVFMECLYSHFHRHFKIHLSATKLVKVSTGIASAHCDGIIKFLQSQYLIGVLMLLTELAISQIQ", "length": 344 }, "evidence": [ { "id": "Q5EA18", "url": "https://omabrowser.org/oma/group/Q5EA18/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3ZAU7-1", "protein_name": "Centromere protein L", "gene_name": "Cenpl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTYDSQGPTSRRRTSNLKDYFVSATPLQKRLKLARRQSSVFPSPSRRKIPQCSQLQEDIDPQKVAFLLHKQWTVYSLTPLYKFSYSNLKDYSRLLSAFIAAEKQKGLAVEVGEDFNIKVIFSTLLGVKGTQRDPEAFLVQIRSESQSSREHRQDKVLWTGWFCCVFGENLQETVSEDFTCLPLFLAHGAESNTSLIGGWFQKTFDCCFSPLAISAFNLSWMAAMWTACKMDHYMATTEFFWSVPCSPQSLDISYAIHPEDAKALWDSVHKTPGEVTQEEVDLFMNCLYSHFHRHFRIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYMTELAIFQIE", "length": 345 }, "evidence": [ { "id": "Q5EA18", "url": "https://omabrowser.org/oma/group/Q5EA18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DRD4-1", "protein_name": "Centromere protein L", "gene_name": "cenpl", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFNLLPAFSLGVLLIVMEGRGSAVNTPASRPVTRKSKSYGRSCVEAPSYFWQTPGHLTVLKVPTSRGAAKSQIITNKVDPEHIALLVKNEWKLSYVTPLHHFRHTQLKSYAKHLSAFIVAEKQQGVAVEVGLDAGFKVTFTAVLGLAETDEDAETVFIQIQSKPVFAAAADAPKVVWRGWLTCVNGDPEYLRSLPPDFVSLPLFCTSGPESLTNLVKSWFERAFDCNFGSLALNSSTLNWLAALWTGCHPACNIRYLKLSWSLPTEPPLDVLYTVNPQDAWELWNSIHPQENTDDRIDIKDVQAFMSGMETHFFRHFKIHLSAGTLLKVSTALGSAHHDGKIKIGNSDYITTLLALLTECALLKMPT", "length": 367 }, "evidence": [ { "id": "Q5EA18", "url": "https://omabrowser.org/oma/group/Q5EA18/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8N0S6-1", "protein_name": "Centromere protein L", "gene_name": "CENPL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE", "length": 344 }, "evidence": [ { "id": "Q5EA18", "url": "https://omabrowser.org/oma/group/Q5EA18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "Q5EA18", "url": "https://www.uniprot.org/uniprotkb/Q5EA18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 346, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA18" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 41, 45, 55 ], "sequon_annotation_sites": [ { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA19-1", "uniprot_ac": "Q5EA19", "uniprot_id": "ARL15_BOVIN", "mass": { "chemical_mass": 22608.0, "monoisotopic_mass": 22608.0 }, "refseq": { "ac": "NP_001014943", "name": "ADP-ribosylation factor-like protein 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" }, "gene_names": [ { "name": "ARL15", "type": "recommended", "evidence": [ { "id": "Q5EA19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA19" } ] }, { "name": "ARFRP2", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] }, { "name": "ARL15", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 15", "type": "recommended", "evidence": [ { "id": "Q5EA19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA19/entry#names_and_taxonomy" } ] }, { "name": "ADP ribosylation factor like GTPase 15", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] }, { "name": "ADP-ribosylation factor related protein 2", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] }, { "name": "ADP-ribosylation factor-like 15", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] }, { "name": "ADP-ribosylation factor-like protein 15", "type": "synonym", "evidence": [ { "id": "NP_001014943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA19", "url": "https://www.uniprot.org/uniprotkb/Q5EA19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL15", "url": "https://www.uniprot.org/uniprotkb/Q5EA19", "locus": { "chromosome": "20", "start_pos": 25221875, "end_pos": 24750157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019834", "url": "https://www.ensembl.org/id/ENSBTAG00000019834" } ] } } ], "crossref": [ { "id": "Q5EA19", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA19", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04162", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04162", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534329", "url": "https://www.ncbi.nlm.nih.gov/gene/534329", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534329", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534329", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA19", "url": "https://www.orthodb.org/?gene=Q5EA19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46693", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46693", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46693:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46693:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014943", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA19", "url": "https://www.uniprot.org/uniprotkb/Q5EA19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA19-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDLRISEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 202, "header": "sp|Q5EA19-1|ARL15_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=2 SV=1 CANONICAL=Q5EA19-1" }, "isoforms": [ { "isoform_ac": "Q5EA19-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA19/entry#Q5EA19-1", "sequence": { "sequence": "MSDLRISEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 202, "header": "sp|Q5EA19-1|ARL15_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=2 SV=1 CANONICAL=Q5EA19-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA19", "url": "https://www.uniprot.org/uniprotkb/Q5EA19" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534329", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534329", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q5EA19", "url": "https://www.uniprot.org/uniprotkb/Q5EA19" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5EA19", "url": "https://www.uniprot.org/uniprotkb/Q5EA19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 202, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA19" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA49-1", "uniprot_ac": "Q5EA49", "uniprot_id": "MIS12_BOVIN", "mass": { "chemical_mass": 24159.0, "monoisotopic_mass": 24159.0 }, "refseq": { "ac": "NP_001070437", "name": "protein MIS12 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437" }, "gene_names": [ { "name": "MIS12", "type": "recommended", "evidence": [ { "id": "Q5EA49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ] }, { "name": "MIS12", "type": "synonym", "evidence": [ { "id": "NP_001070437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437" } ] } ], "protein_names": [ { "name": "Protein MIS12 homolog", "type": "recommended", "evidence": [ { "id": "Q5EA49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA49/entry#names_and_taxonomy" } ] }, { "name": "MIS12 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437" } ] }, { "name": "MIS12, MIND kinetochore complex component, homolog", "type": "synonym", "evidence": [ { "id": "NP_001070437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437" } ] }, { "name": "protein MIS12 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437" } ] } ], "function": [ { "annotation": "Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Essential for proper kinetochore microtubule attachments.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49#function" }, { "database": "UniProtKB", "id": "Q9H081", "url": "https://www.uniprot.org/uniprotkb/Q9H081#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIS12", "url": "https://www.uniprot.org/uniprotkb/Q5EA49", "locus": { "chromosome": "19", "start_pos": 26067601, "end_pos": 26083646, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020432", "url": "https://www.ensembl.org/id/ENSBTAG00000020432" } ] } } ], "crossref": [ { "id": "Q5EA49", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020432", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020432", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767858", "url": "https://www.ncbi.nlm.nih.gov/gene/767858", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767858", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767858", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DYLFEMM", "url": "https://omabrowser.org/oma/group/DYLFEMM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA49", "url": "https://www.orthodb.org/?gene=Q5EA49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14527", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14527", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14527:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14527:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05859", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05859", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070437", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA49-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCAISPVEIRKCTEKFLCFMKGRFDNLFGKMEQLFLQLILRIPPNVLLPEDKSQETQSYSEEEFHFLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLSLFDELENVGRDHGASDFREGLVFLIQNSRKLQNIRENVEKEGKRLKIS", "length": 206, "header": "sp|Q5EA49-1|MIS12_BOVIN Isoform 1 of Protein MIS12 homolog OS=Bos taurus OX=9913 GN=MIS12 PE=2 SV=1 CANONICAL=Q5EA49-1" }, "isoforms": [ { "isoform_ac": "Q5EA49-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA49/entry#Q5EA49-1", "sequence": { "sequence": "MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCAISPVEIRKCTEKFLCFMKGRFDNLFGKMEQLFLQLILRIPPNVLLPEDKSQETQSYSEEEFHFLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLSLFDELENVGRDHGASDFREGLVFLIQNSRKLQNIRENVEKEGKRLKIS", "length": 206, "header": "sp|Q5EA49-1|MIS12_BOVIN Isoform 1 of Protein MIS12 homolog OS=Bos taurus OX=9913 GN=MIS12 PE=2 SV=1 CANONICAL=Q5EA49-1" }, "locus": { "chromosome": "19", "start_pos": 26070021, "end_pos": 26069404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027230.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027230.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027230.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027230.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:767858", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767858", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIK7-1", "protein_name": "Protein MIS12 homolog", "gene_name": "MIS12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVVLKKLDGIPDCAVSPVQIRKCTEKFLCFMKGRFDNLFGKMEQLFLQLILRIPPNILLPEDKSQELHPCSEEEFHLLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLSLFDELENIGRDHGTSDFRESLVFLVQNSRKLQNIRDNVEKEGKRLKIT", "length": 206 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AL28-1", "protein_name": "Protein MIS12 homolog", "gene_name": "MIS12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSVRPMAYETQFFGFTPQTCMLRIYLAFQDYLFEMMVVVESVILKKLEALPAVQISRFEIRKSTEKFLHFMKARFDQLFEKMEEVLLQLVLSIPDNVLLPEDRVHQQYPYSQEEFCALQDEISQLQQQCRAEAAAGQALHAELEEQRAVQAELEKVVQWFDGLENVCREHGTGNFKESLVFLTQNCKKLQDVLRDVEEKSKKIKKRQQLL", "length": 210 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GYE0-1", "protein_name": "Protein MIS12 homolog", "gene_name": "Mis12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSVDPMAYEAQFFGFTPQTCLLRIYIAFQDHLFEVMQAVEHVILKKLEGMPDSEISPVQIRKCTEKFLCFMKGRFDNLFGRMEQLILQSVLCIPPNILLPEDKCQETHPFNEEKFQLLKKEIEELQEKYKVELRTEQALLAELEEQKAVKAKLKETLTFFDELENIGRDHGTSNFRESLVSLVQNCRKLQNIRDNVEKQSKRLETL", "length": 206 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7TQ72-1", "protein_name": "Protein MIS12 homolog", "gene_name": "Mis12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVDPMAYEAQFFGFTPQTCLLRIYIAFQDHLFEVMQAVEQVILKKLEGIPDCEISSIQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILQIPPNILLPEDKCQETNPFSEEKFQLLKQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLVSLVQNCRKLQDIRDNVEKEGKRLETQ", "length": 206 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CY25-1", "protein_name": "Protein MIS12 homolog", "gene_name": "Mis12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVDPMAYEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLEDIPNCEITPVQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILCIPPNILLPEDKCQETNPFSEEKLELLQQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLASLVQSCRKLQSIRDNVEKESRRLETQ", "length": 206 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H081-1", "protein_name": "Protein MIS12 homolog", "gene_name": "MIS12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS", "length": 205 }, "evidence": [ { "id": "Q5EA49", "url": "https://omabrowser.org/oma/group/Q5EA49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "attachment of mitotic spindle microtubules to kinetochore", "id": "GO:0051315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051315", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" }, { "name": "kinetochore assembly", "id": "GO:0051382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051382", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" }, { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" }, { "name": "MIS12/MIND type complex", "id": "GO:0000444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000444", "evidence": [ { "database": "UniProtKB", "id": "Q5EA49", "url": "https://www.uniprot.org/uniprotkb/Q5EA49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 206, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA50-1", "uniprot_ac": "Q5EA50", "uniprot_id": "RABEK_BOVIN", "mass": { "chemical_mass": 40362.0, "monoisotopic_mass": 40362.0 }, "refseq": { "ac": "NP_001030476", "name": "rab9 effector protein with kelch motifs", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476" }, "gene_names": [ { "name": "RABEPK", "type": "recommended", "evidence": [ { "id": "Q5EA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA50" } ] }, { "name": "RAB9P40", "type": "synonym", "evidence": [ { "id": "NP_001030476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476" } ] }, { "name": "RABEPK", "type": "synonym", "evidence": [ { "id": "NP_001030476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476" } ] } ], "protein_names": [ { "name": "Rab9 effector protein with kelch motifs", "type": "recommended", "evidence": [ { "id": "Q5EA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA50/entry#names_and_taxonomy" } ] }, { "name": "Rab9 effector p40", "type": "synonym", "evidence": [ { "id": "NP_001030476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476" } ] }, { "name": "rab9 effector protein with kelch motifs", "type": "synonym", "evidence": [ { "id": "NP_001030476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476" } ] } ], "function": [ { "annotation": "Rab9 effector required for endosome to trans-Golgi network (TGN) transport.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA50", "url": "https://www.uniprot.org/uniprotkb/Q5EA50#function" }, { "database": "UniProtKB", "id": "Q7Z6M1", "url": "https://www.uniprot.org/uniprotkb/Q7Z6M1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA50", "url": "https://www.uniprot.org/uniprotkb/Q5EA50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABEPK", "url": "https://www.uniprot.org/uniprotkb/Q5EA50", "locus": { "chromosome": "11", "start_pos": 96114095, "end_pos": 96085411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015098", "url": "https://www.ensembl.org/id/ENSBTAG00000015098" } ] } } ], "crossref": [ { "id": "Q5EA50", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA50", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015098", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015098", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533613", "url": "https://www.ncbi.nlm.nih.gov/gene/533613", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533613", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533613", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTPGSIW", "url": "https://omabrowser.org/oma/group/CTPGSIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA50", "url": "https://www.orthodb.org/?gene=Q5EA50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46647:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46647:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030476", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA50", "url": "https://www.uniprot.org/uniprotkb/Q5EA50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA50-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQLPVLEPGDKPRKETWYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 372, "header": "sp|Q5EA50-1|RABEK_BOVIN Isoform 1 of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=2 SV=1 CANONICAL=Q5EA50-1" }, "isoforms": [ { "isoform_ac": "Q5EA50-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA50/entry#Q5EA50-1", "sequence": { "sequence": "MKQLPVLEPGDKPRKETWYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 372, "header": "sp|Q5EA50-1|RABEK_BOVIN Isoform 1 of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=2 SV=1 CANONICAL=Q5EA50-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA50", "url": "https://www.uniprot.org/uniprotkb/Q5EA50" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533613", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533613", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BR94-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "RABEPK", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKQLPVLEPGDKPRKATWYTLTPTGDSPCARVGHSCSYLPPVGDSKRGKVFIVGGANPNRSFSDVHTMDLGTHQWDLTTSEGLLPRYEHASFVPSCAPHSIWVFGGADQSGNRNCLQVLNPETRTWTMPEVTSPPPSPRTFHTSSSVIGNQLYVFGGGERGAQPVQDVKLHVFDANTLTWSQPETLGEPPSPRHGHVMVAAGTKLFIHGGLAGDKFYDDLHCIDINDMKWQKLSPTGAAPTGCAAHSAVTVGKHVYIFGGMTPTGALDTMYQYHIEKQHWTLLKFDSFLPPGRLDHAMCIIPWAERCTSEKNSNSAVLNCDAEKGNSTEKGVTQDDDSQERQSDTLLCFVFGGMNTEGEIYNDCIVTVVD", "length": 370 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I8S0-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "Rabepk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKQLPVLEPGDKPRKATWYTLTRPGDKPCPRVGHSCSYLPPAGDAKRGKVFIVGGANPNQSFSDVHIMDLGTQQWDTVTTEGLLPRYEHASFIPSCTPHSIWVFGGADQSGNRNCLQVLDPETRTWTTPEVSSPPPSPRTFHTSAAAIGNQLYVFGGGERGDQPVQDVKLHVFDANTLMWSQPETHGSPPSARHGHVMVATGTKLFVHGGLSGDKFFDDLHCIDISNMKWQKLSPTGAVPAGCAAHAAVAVGKHVYMFGGMTPSGALNTMYKYHTEKQHWTSLQFDTFLPPGRLDHSMCVIPWPVMSTSENEDSDSVILKCEAEKGDAADIQVAQGGGLPEESQTNMLLCFVFGGMNTEGEIYDDCFVTVVD", "length": 372 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4V8F4-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "Rabepk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKQLPILEPGDKPRKAAWYTLTCPGDKPCPRVGHSCSYFPPVGEAEKGKVFIVGGANPNQSFSDVHTMDLGTHRWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMNPEARTWSTPEVTGCPPSPRTFHTSSAAIGNHLYVFGGGERGAQPVQDVKLHVFDANTLTWAQPETHGSPPSPRHGHAMVAAGTKLFIHGGLAGDRFFDDLHCIDIGDMSWQKLGPTGTAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHTEKQHWTILQFDTSLPPGRLDHSMCVIPWPVMSASDTEDSGSVILSLQDEKGDAAEKPETRSGGSREESPTTLLLCFVFGGMNTEGEIYDDCLVTVVD", "length": 372 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6GQN7-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "rabepk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELIPVLEPEQKPQNRHWYVLEPTGAAPGVSVGHTCSFLPAAHHHDEDGGGKGKIVIVGGANPSGSFADSYIINLDTHQWDLPDWEGLQARYEHCSFTPESEPQSLWVFGGAEKSTNRNCVQALRFSDGGEGRRFWQSVQVTGVPPSGRTYHTNSACVGNRLFVFSGGEAGSSAVTDAQLHVFDAVSVTWTQPDTTGTPPAQRHGHVITAVGSDIYIHGGMSGEKFHSDMFTLNTESLKWQKVKAKGDLPPGVAAHSSVTFNKNIFIFGGMTADGATNSMFKFQCDKQRWTLLKFEGDLPPGRLDHSMCLLPWRVKMEDSEHADVQHLCFVFGGMDTQGVIFNDCLVTVLT", "length": 351 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7Z6M1-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "RABEPK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD", "length": 372 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCH5-1", "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "Rabepk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGLRQGIMKQLPILEPGDKPRKATWYTLTCPGDRPCPRVGHSCSYFPPVGDAESGKIFIVGGANPNQSFSDVHTMDLGTHQWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMSPEDRTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVEDVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWTVLQFDTSLPAGRLDHSMCVIPWPVMSTSENKDSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLLCFVFGGMNTEGEVYDDCLVTVVD", "length": 380 }, "evidence": [ { "id": "Q5EA50", "url": "https://omabrowser.org/oma/group/Q5EA50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q5EA50", "url": "https://www.uniprot.org/uniprotkb/Q5EA50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA50-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 372, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA50-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA50" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA70-1", "uniprot_ac": "Q5EA70", "uniprot_id": "T229B_BOVIN", "mass": { "chemical_mass": 19519.0, "monoisotopic_mass": 19519.0 }, "refseq": { "ac": "NP_001026938", "name": "transmembrane protein 229B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938" }, "gene_names": [ { "name": "TMEM229B", "type": "recommended", "evidence": [ { "id": "Q5EA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA70" } ] }, { "name": "C10H14orf83", "type": "synonym", "evidence": [ { "id": "NP_001026938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938" } ] }, { "name": "C14orf83", "type": "synonym", "evidence": [ { "id": "NP_001026938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938" } ] }, { "name": "TMEM229B", "type": "synonym", "evidence": [ { "id": "NP_001026938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938" } ] } ], "protein_names": [ { "name": "Transmembrane protein 229B", "type": "recommended", "evidence": [ { "id": "Q5EA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA70/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 229B", "type": "synonym", "evidence": [ { "id": "NP_001026938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA70", "url": "https://www.uniprot.org/uniprotkb/Q5EA70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM229B", "url": "https://www.uniprot.org/uniprotkb/Q5EA70", "locus": { "chromosome": "10", "start_pos": 79345961, "end_pos": 79360144, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012900", "url": "https://www.ensembl.org/id/ENSBTAG00000012900" } ] } } ], "crossref": [ { "id": "Q5EA70", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012900", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012900", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536375", "url": "https://www.ncbi.nlm.nih.gov/gene/536375", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536375", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536375", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DGWSNHR", "url": "https://omabrowser.org/oma/group/DGWSNHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA70", "url": "https://www.orthodb.org/?gene=Q5EA70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31746", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31746", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31746:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31746:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026938", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA70", "url": "https://www.uniprot.org/uniprotkb/Q5EA70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA70-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLLRCLIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALLVEQFVIRNTLRLRFDKDAEPGEPSGALALANGHVKTD", "length": 167, "header": "sp|Q5EA70-1|T229B_BOVIN Isoform 1 of Transmembrane protein 229B OS=Bos taurus OX=9913 GN=TMEM229B PE=2 SV=1 CANONICAL=Q5EA70-1" }, "isoforms": [ { "isoform_ac": "Q5EA70-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA70/entry#Q5EA70-1", "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLLRCLIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALLVEQFVIRNTLRLRFDKDAEPGEPSGALALANGHVKTD", "length": 167, "header": "sp|Q5EA70-1|T229B_BOVIN Isoform 1 of Transmembrane protein 229B OS=Bos taurus OX=9913 GN=TMEM229B PE=2 SV=1 CANONICAL=Q5EA70-1" }, "locus": { "chromosome": "10", "start_pos": 79349827, "end_pos": 79349327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079794.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA70", "url": "https://www.uniprot.org/uniprotkb/Q5EA70" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:536375", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536375", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ACC3-1", "protein_name": "Transmembrane protein 229B", "gene_name": "Tmem229b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLVRCVIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALIMEQFIIRNTLRLRFDKDAEPGEPASPPALANGHVKTD", "length": 167 }, "evidence": [ { "id": "Q5EA70", "url": "https://omabrowser.org/oma/group/Q5EA70/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H1M1-1", "protein_name": "Transmembrane protein 229B", "gene_name": "Tmem229b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLVRCLIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALIMEQFIIRNTLRLRFDKDAEPGEPASPPALANGHVKTD", "length": 167 }, "evidence": [ { "id": "Q5EA70", "url": "https://omabrowser.org/oma/group/Q5EA70/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5F3L7-1", "protein_name": "Transmembrane protein 229B", "gene_name": "TMEM229B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAEPLTAFSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVEKMYLYLKDKCHILVRCFIYTLWTYLWEFTTGLILRQFNACPWDYSQFDFDFMGLITLEYAIPWFCASFIMEQLVIRNTLRLRFDETAEPGAPTVPVALANGHVKTD", "length": 167 }, "evidence": [ { "id": "Q5EA70", "url": "https://omabrowser.org/oma/group/Q5EA70/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BFQ2-1", "protein_name": "Transmembrane protein 229B", "gene_name": "TMEM229B", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLVRCVIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALIMEQFIIRNTLRLRFDKDAEPGEPASPPALANGHVKTD", "length": 167 }, "evidence": [ { "id": "Q5EA70", "url": "https://omabrowser.org/oma/group/Q5EA70/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NBD8-1", "protein_name": "Transmembrane protein 229B", "gene_name": "TMEM229B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNLNWKFPGVTSVWALFIYGTSILIVERMYLRLRGRCPLLLRCLIYTLWTYLWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAVPWFCGALIMEQFIIRNTLRLRFDKDAEPGEPSGALALANGHVKTD", "length": 167 }, "evidence": [ { "id": "Q5EA70", "url": "https://omabrowser.org/oma/group/Q5EA70/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EA70", "url": "https://www.uniprot.org/uniprotkb/Q5EA70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA70-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 167, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA70-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA70" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA86-1", "uniprot_ac": "Q5EA86", "uniprot_id": "TM183_BOVIN", "mass": { "chemical_mass": 42847.0, "monoisotopic_mass": 42847.0 }, "refseq": { "ac": "NP_001029788", "name": "transmembrane protein 183", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788" }, "gene_names": [ { "name": "TMEM183", "type": "recommended", "evidence": [ { "id": "Q5EA86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA86" } ] }, { "name": "C1orf37", "type": "synonym", "evidence": [ { "id": "NP_001029788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788" } ] }, { "name": "TMEM183A", "type": "synonym", "evidence": [ { "id": "NP_001029788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788" } ] }, { "name": "TMEM183", "type": "synonym", "evidence": [ { "id": "NP_001029788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788" } ] } ], "protein_names": [ { "name": "Transmembrane protein 183", "type": "recommended", "evidence": [ { "id": "Q5EA86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA86/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 183", "type": "synonym", "evidence": [ { "id": "NP_001029788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA86", "url": "https://www.uniprot.org/uniprotkb/Q5EA86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM183", "url": "https://www.uniprot.org/uniprotkb/Q5EA86", "locus": {} } ], "crossref": [ { "id": "Q5EA86", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA86", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002874", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002874", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534797", "url": "https://www.ncbi.nlm.nih.gov/gene/534797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFKSKCC", "url": "https://omabrowser.org/oma/group/RFKSKCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA86", "url": "https://www.orthodb.org/?gene=Q5EA86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20988", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20988", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20988:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20988:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029788", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA86", "url": "https://www.uniprot.org/uniprotkb/Q5EA86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA86-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHREDLNGTGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTISVSTDMRHHRVRLVFQDYPVHGGQKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 376, "header": "sp|Q5EA86-1|TM183_BOVIN Isoform 1 of Transmembrane protein 183 OS=Bos taurus OX=9913 GN=TMEM183 PE=2 SV=1 CANONICAL=Q5EA86-1" }, "isoforms": [ { "isoform_ac": "Q5EA86-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA86/entry#Q5EA86-1", "sequence": { "sequence": "MARGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHREDLNGTGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTISVSTDMRHHRVRLVFQDYPVHGGQKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 376, "header": "sp|Q5EA86-1|TM183_BOVIN Isoform 1 of Transmembrane protein 183 OS=Bos taurus OX=9913 GN=TMEM183 PE=2 SV=1 CANONICAL=Q5EA86-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA86", "url": "https://www.uniprot.org/uniprotkb/Q5EA86" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S7U5-1", "protein_name": "Transmembrane protein 183A", "gene_name": "TMEM183A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAVEALSGAGEPCDIIDSSDEIDAQEESIHERTVCRKKKSKRHKEDLDRAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 376 }, "evidence": [ { "id": "Q5EA86", "url": "https://omabrowser.org/oma/group/Q5EA86/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H3L2-1", "protein_name": "Transmembrane protein 183A", "gene_name": "Tmem183a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARGPGQLSGPHSDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGVGEPSDVMDSSDEMDAQEESTHERSVSRKKKSKRHKEDLDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGSRQEPMWEFNFKFKKQSPRLKSKCMERLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVRGGQNLRSEQGVQVVLDPVHSVRLFDWWHPQYPFSLRA", "length": 376 }, "evidence": [ { "id": "Q5EA86", "url": "https://omabrowser.org/oma/group/Q5EA86/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8IXX5-1", "protein_name": "Transmembrane protein 183A", "gene_name": "TMEM183A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDAQEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 376 }, "evidence": [ { "id": "Q5EA86", "url": "https://omabrowser.org/oma/group/Q5EA86/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJB9-1", "protein_name": "Transmembrane protein 183", "gene_name": "Tmem183", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARGSGQLGGPHRDTVTMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAIQQEVKSLCGLEASQVPAEEALSGVGEPCDILDSSDEMDAQEESTQERSVSRKKKSKRHKEDPDGTGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMERLQPPIQYQDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVRGGQNLRSEQGVQVVLDPVHSVRLFDWWHPQYPFSLRA", "length": 375 }, "evidence": [ { "id": "Q5EA86", "url": "https://omabrowser.org/oma/group/Q5EA86/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EA86", "url": "https://www.uniprot.org/uniprotkb/Q5EA86" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q5EA86", "url": "https://www.uniprot.org/uniprotkb/Q5EA86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA86-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA86-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA86" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 152, "end_pos": 154 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA89-1", "uniprot_ac": "Q5EA89", "uniprot_id": "FA76A_BOVIN", "mass": { "chemical_mass": 35118.0, "monoisotopic_mass": 35118.0 }, "refseq": { "ac": "NP_001015660", "name": "protein FAM76A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015660" }, "gene_names": [ { "name": "FAM76A", "type": "recommended", "evidence": [ { "id": "Q5EA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA89" } ] }, { "name": "FAM76A", "type": "synonym", "evidence": [ { "id": "NP_001015660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015660" } ] } ], "protein_names": [ { "name": "Protein FAM76A", "type": "recommended", "evidence": [ { "id": "Q5EA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA89/entry#names_and_taxonomy" } ] }, { "name": "protein FAM76A", "type": "synonym", "evidence": [ { "id": "NP_001015660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015660" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA89", "url": "https://www.uniprot.org/uniprotkb/Q5EA89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM76A", "url": "https://www.uniprot.org/uniprotkb/Q5EA89", "locus": { "chromosome": "2", "start_pos": 125604197, "end_pos": 125635540, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019614", "url": "https://www.ensembl.org/id/ENSBTAG00000019614" } ] } } ], "crossref": [ { "id": "Q5EA89", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA89", "database": "AlphaFoldDB", "categories": [] }, { "id": "535402", "url": "https://www.ncbi.nlm.nih.gov/gene/535402", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535402", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535402", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA89", "url": "https://www.orthodb.org/?gene=Q5EA89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46176:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46176:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015660", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA89", "url": "https://www.uniprot.org/uniprotkb/Q5EA89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA89-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALYACTKCHQRFPFEALSQGQQLCKECRIAHPVVKCTYCRTEYQQESKTNTICKKCAQNVQLYGTPKPCQYCNIIAAFIGNKCQRCTNSEKKYGPPYSCEQCKQQCAFDRKDDRKKVDGKLLCWLCTLSYKRVLQKTKEQRKHLSSSSRASHHEKEQYSRLSGGSHYNSQKTLSTSSIQNEIPKKKSKFESITTNGDSFSPDLALDSPGTDHFVIIAQLKEEVATLKKMLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEKTHKEVTEQLQAKNRELLKQAAALSKSKKSEKSGAITSP", "length": 307, "header": "sp|Q5EA89-1|FA76A_BOVIN Isoform 1 of Protein FAM76A OS=Bos taurus OX=9913 GN=FAM76A PE=2 SV=1 CANONICAL=Q5EA89-1" }, "isoforms": [ { "isoform_ac": "Q5EA89-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA89/entry#Q5EA89-1", "sequence": { "sequence": "MAALYACTKCHQRFPFEALSQGQQLCKECRIAHPVVKCTYCRTEYQQESKTNTICKKCAQNVQLYGTPKPCQYCNIIAAFIGNKCQRCTNSEKKYGPPYSCEQCKQQCAFDRKDDRKKVDGKLLCWLCTLSYKRVLQKTKEQRKHLSSSSRASHHEKEQYSRLSGGSHYNSQKTLSTSSIQNEIPKKKSKFESITTNGDSFSPDLALDSPGTDHFVIIAQLKEEVATLKKMLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEKTHKEVTEQLQAKNRELLKQAAALSKSKKSEKSGAITSP", "length": 307, "header": "sp|Q5EA89-1|FA76A_BOVIN Isoform 1 of Protein FAM76A OS=Bos taurus OX=9913 GN=FAM76A PE=2 SV=1 CANONICAL=Q5EA89-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA89", "url": "https://www.uniprot.org/uniprotkb/Q5EA89" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535402", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535402", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5EA89", "url": "https://www.uniprot.org/uniprotkb/Q5EA89" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q5EA89", "url": "https://www.uniprot.org/uniprotkb/Q5EA89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA89-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA89-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA89" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA91-1", "uniprot_ac": "Q5EA91", "uniprot_id": "TM164_BOVIN", "mass": { "chemical_mass": 29275.0, "monoisotopic_mass": 29275.0 }, "refseq": { "ac": "NP_001026932", "name": "transmembrane protein 164", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026932" }, "gene_names": [ { "name": "TMEM164", "type": "recommended", "evidence": [ { "id": "Q5EA91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA91" } ] }, { "name": "TMEM164", "type": "synonym", "evidence": [ { "id": "NP_001026932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026932" } ] } ], "protein_names": [ { "name": "Transmembrane protein 164", "type": "recommended", "evidence": [ { "id": "Q5EA91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA91/entry#names_and_taxonomy" } ] }, { "name": "Arachidonoyl ether phospholipid synthase", "type": "synonym", "evidence": [ { "id": "Q5EA91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA91/entry#names_and_taxonomy" } ] }, { "name": "arachidonoyl ether phospholipid synthase", "type": "synonym", "evidence": [ { "id": "NP_001026932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026932" } ] }, { "name": "transmembrane protein 164", "type": "synonym", "evidence": [ { "id": "NP_001026932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026932" } ] } ], "function": [ { "annotation": "Positive regulator of ferroptosis. Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91#function" }, { "database": "UniProtKB", "id": "Q5U3C3", "url": "https://www.uniprot.org/uniprotkb/Q5U3C3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM164", "url": "https://www.uniprot.org/uniprotkb/Q5EA91", "locus": { "chromosome": "X", "start_pos": 58598447, "end_pos": 58422924, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037413", "url": "https://www.ensembl.org/id/ENSBTAG00000037413" } ] } } ], "crossref": [ { "id": "Q5EA91", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA91", "database": "AlphaFoldDB", "categories": [] }, { "id": "524183", "url": "https://www.ncbi.nlm.nih.gov/gene/524183", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524183", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524183", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA91", "url": "https://www.orthodb.org/?gene=Q5EA91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20948", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20948", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20948:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20948:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14808", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14808", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "79431", "url": "https://www.rhea-db.org/rhea/79431", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA91-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTKEDGRGGRGCQPEQVTQRPEEGKESLSKNLLLVALCLTFGVEVGFKFATKTVIYLLNPCHLVTMMHLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALPSTGLMFFYHFSILQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID", "length": 258, "header": "sp|Q5EA91-1|TM164_BOVIN Isoform 1 of Transmembrane protein 164 OS=Bos taurus OX=9913 GN=TMEM164 PE=2 SV=1 CANONICAL=Q5EA91-1" }, "isoforms": [ { "isoform_ac": "Q5EA91-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA91/entry#Q5EA91-1", "sequence": { "sequence": "MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTKEDGRGGRGCQPEQVTQRPEEGKESLSKNLLLVALCLTFGVEVGFKFATKTVIYLLNPCHLVTMMHLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALPSTGLMFFYHFSILQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID", "length": 258, "header": "sp|Q5EA91-1|TM164_BOVIN Isoform 1 of Transmembrane protein 164 OS=Bos taurus OX=9913 GN=TMEM164 PE=2 SV=1 CANONICAL=Q5EA91-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:524183", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524183", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of ferroptosis", "id": "GO:0160020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160020", "evidence": [ { "database": "UniProtKB", "id": "Q5EA91", "url": "https://www.uniprot.org/uniprotkb/Q5EA91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "79431", "name": "", "equation": "1-(1Z-octadecenyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "79431", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79431" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA91-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA91-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA91" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA92-1", "uniprot_ac": "Q5EA92", "uniprot_id": "AL14E_BOVIN", "mass": { "chemical_mass": 29209.0, "monoisotopic_mass": 29209.0 }, "refseq": { "ac": "NP_001026931", "name": "ARL14 effector protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" }, "gene_names": [ { "name": "ARL14EP", "type": "recommended", "evidence": [ { "id": "Q5EA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ] }, { "name": "ARF7EP", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" }, { "id": "Q5EA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ] }, { "name": "ARL14EP", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] }, { "name": "C11orf46", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] }, { "name": "C15H11orf46", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] } ], "protein_names": [ { "name": "ARL14 effector protein", "type": "recommended", "evidence": [ { "id": "Q5EA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA92/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like 14 effector protein", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] }, { "name": "ARF7 effector protein", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" }, { "id": "Q5EA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA92/entry#names_and_taxonomy" } ] }, { "name": "ARL14 effector protein", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] }, { "name": "uncharacterized protein C11orf46 homolog", "type": "synonym", "evidence": [ { "id": "NP_001026931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931" } ] } ], "function": [ { "annotation": "Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL14EP", "url": "https://www.uniprot.org/uniprotkb/Q5EA92", "locus": { "chromosome": "15", "start_pos": 61061501, "end_pos": 61047887, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012417", "url": "https://www.ensembl.org/id/ENSBTAG00000012417" } ] } } ], "crossref": [ { "id": "Q5EA92", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012417", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523894", "url": "https://www.ncbi.nlm.nih.gov/gene/523894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523894", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523894", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECHKIYY", "url": "https://omabrowser.org/oma/group/ECHKIYY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA92", "url": "https://www.orthodb.org/?gene=Q5EA92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46536", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46536", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46536:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46536:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14949", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14949", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026931", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA92-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHAKVYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDSEDRQKRKPDSDGRTAKALRSLQFANPGKQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG", "length": 260, "header": "sp|Q5EA92-1|AL14E_BOVIN Isoform 1 of ARL14 effector protein OS=Bos taurus OX=9913 GN=ARL14EP PE=2 SV=1 CANONICAL=Q5EA92-1" }, "isoforms": [ { "isoform_ac": "Q5EA92-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA92/entry#Q5EA92-1", "sequence": { "sequence": "MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHAKVYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDSEDRQKRKPDSDGRTAKALRSLQFANPGKQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG", "length": 260, "header": "sp|Q5EA92-1|AL14E_BOVIN Isoform 1 of ARL14 effector protein OS=Bos taurus OX=9913 GN=ARL14EP PE=2 SV=1 CANONICAL=Q5EA92-1" }, "locus": { "chromosome": "15", "start_pos": 61061190, "end_pos": 61057647, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044657.3", "url": "https://www.ensembl.org/id/ENSBTAT00000044657.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000042134.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ], "site_lbl": "Ser183" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:523894", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523894", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A2Y6-1", "protein_name": "ADP ribosylation factor like GTPase 14 effector protein", "gene_name": "ARL14EP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHAKIYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDSEDRQRRKPDSDGRTAKALRSLQFANPGKQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG", "length": 260 }, "evidence": [ { "id": "Q5EA92", "url": "https://omabrowser.org/oma/group/Q5EA92/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5FVK8-1", "protein_name": "ARL14 effector protein", "gene_name": "Arl14ep", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPCSVGVQLRTTHDCHKTFYTRHTGFKTLKELSSNDMLLLQLRTGMTLSGNNTICLHHVKIYIERFEELQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDSDDRQRRKPESDGRTAKALRSLQFTNPGKQTEFAPESGKREKRKLTKNASASSDRQIIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPTCGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAGKAYGLLSPCHPYDILQK", "length": 276 }, "evidence": [ { "id": "Q5EA92", "url": "https://omabrowser.org/oma/group/Q5EA92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BIX3-1", "protein_name": "ARL14 effector protein", "gene_name": "Arl14ep", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPCSVGVQLRTTHDCHKTFYTRHTGFKTLKELSSNDMLLLQLRTGMTLSGNNTICLHHVKIYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDSDDRQRRKPDSDGRTAKALRSLQFTNPGKQTEFAPEGGKREKRKLTKATSAASDRQIIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPTCGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAGKAYGLLSPCHPYDILQK", "length": 276 }, "evidence": [ { "id": "Q5EA92", "url": "https://omabrowser.org/oma/group/Q5EA92/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8R7-1", "protein_name": "ARL14 effector protein", "gene_name": "ARL14EP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHVKIYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDTEDRQKRKPESDGRTAKALRSLQFTNPGRQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG", "length": 260 }, "evidence": [ { "id": "Q5EA92", "url": "https://omabrowser.org/oma/group/Q5EA92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EA92", "url": "https://www.uniprot.org/uniprotkb/Q5EA92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 260, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 183 ], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 178, "end_pos": 180 }, { "start_pos": 53, "end_pos": 55 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA97-1", "uniprot_ac": "Q5EA97", "uniprot_id": "S38AB_BOVIN", "mass": { "chemical_mass": 50745.0, "monoisotopic_mass": 50745.0 }, "refseq": { "ac": "NP_001026930", "name": "putative sodium-coupled neutral amino acid transporter 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026930" }, "gene_names": [ { "name": "SLC38A11", "type": "recommended", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ] }, { "name": "SLC38A11", "type": "synonym", "evidence": [ { "id": "NP_001026930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026930" } ] } ], "protein_names": [ { "name": "Putative sodium-coupled neutral amino acid transporter 11", "type": "recommended", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 38 member 11", "type": "synonym", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97/entry#names_and_taxonomy" } ] }, { "name": "putative sodium-coupled neutral amino acid transporter 11", "type": "synonym", "evidence": [ { "id": "NP_001026930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026930" } ] } ], "function": [ { "annotation": "Putative sodium-dependent amino acid/proton antiporter.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC38A11", "url": "https://www.uniprot.org/uniprotkb/Q5EA97", "locus": { "chromosome": "2", "start_pos": 31348547, "end_pos": 31290418, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007650", "url": "https://www.ensembl.org/id/ENSBTAG00000007650" } ] } } ], "crossref": [ { "id": "Q5EA97", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA97", "database": "AlphaFoldDB", "categories": [] }, { "id": "523418", "url": "https://www.ncbi.nlm.nih.gov/gene/523418", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523418", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523418", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA97", "url": "https://www.orthodb.org/?gene=Q5EA97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950:SF458", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950:SF458", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA97-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHFQLTTQLSILNVSIFQ", "length": 463, "header": "sp|Q5EA97-1|S38AB_BOVIN Isoform 1 of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=2 SV=1 CANONICAL=Q5EA97-1" }, "isoforms": [ { "isoform_ac": "Q5EA97-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA97/entry#Q5EA97-1", "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHFQLTTQLSILNVSIFQ", "length": 463, "header": "sp|Q5EA97-1|S38AB_BOVIN Isoform 1 of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=2 SV=1 CANONICAL=Q5EA97-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 437, "start_aa": "Asn", "end_pos": 437, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn437", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 442, "start_aa": "Asn", "end_pos": 442, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn442", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 458, "start_aa": "Asn", "end_pos": 458, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn458", "evidence": [ { "id": "Q5EA97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA97#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:523418", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523418", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-amino acid transmembrane transporter activity", "id": "GO:0015179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015179", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "pmid": "" }, { "name": "amino acid transmembrane transport", "id": "GO:0003333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003333", "evidence": [ { "database": "UniProtKB", "id": "Q5EA97", "url": "https://www.uniprot.org/uniprotkb/Q5EA97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 463, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA97" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 437, 442, 458 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 442, "end_pos": 444 }, { "start_pos": 458, "end_pos": 460 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA99-1", "uniprot_ac": "Q5EA99", "uniprot_id": "PK1IP_BOVIN", "mass": { "chemical_mass": 44049.0, "monoisotopic_mass": 44049.0 }, "refseq": { "ac": "NP_001014852", "name": "p21-activated protein kinase-interacting protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014852" }, "gene_names": [ { "name": "PAK1IP1", "type": "recommended", "evidence": [ { "id": "Q5EA99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ] }, { "name": "PAK1IP1", "type": "synonym", "evidence": [ { "id": "NP_001014852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014852" } ] } ], "protein_names": [ { "name": "p21-activated protein kinase-interacting protein 1", "type": "recommended", "evidence": [ { "id": "Q5EA99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA99/entry#names_and_taxonomy" } ] }, { "name": "PAK1-interacting protein 1", "type": "synonym", "evidence": [ { "id": "Q5EA99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA99/entry#names_and_taxonomy" } ] }, { "name": "p21-activated protein kinase-interacting protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014852" } ] } ], "function": [ { "annotation": "Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99#function" }, { "database": "UniProtKB", "id": "Q9NWT1", "url": "https://www.uniprot.org/uniprotkb/Q9NWT1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAK1IP1", "url": "https://www.uniprot.org/uniprotkb/Q5EA99", "locus": { "chromosome": "23", "start_pos": 45417558, "end_pos": 45428505, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018674", "url": "https://www.ensembl.org/id/ENSBTAG00000018674" } ] } } ], "crossref": [ { "id": "Q5EA99", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA99", "database": "AlphaFoldDB", "categories": [] }, { "id": "505125", "url": "https://www.ncbi.nlm.nih.gov/gene/505125", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505125", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505125", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA99", "url": "https://www.orthodb.org/?gene=Q5EA99", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44675:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44675:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA99-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVVAGCYEQVLFGFAVHPEPVGDGHRERWAPVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKVDHGALMHHNGTITCLKFHGNRHLISGAEDGLICVWDARRWECLKSIRAHKGHVTFLSIHPSGRLALSVGTDKTLRTWNLVEGRSAFIKNIKQSAHIVEWSPKGEKYVVVILNRIDVYQLDTASVSGTITNERRVSSVTFLSESVLTVAGDEEVVRFFDCDSLTCLSEFKAHENRVKDMFSFETPEHHVLVTASSDGFIKMWKLKQDKKVSPSLLCEINTNARLTCLGVWLDRRTDTKESPPAAAEPAPVSKEQSRRNKEESGHAVQEEEKQPKPDTEKCSLTGDSNKPTRGNSLVSAKKRKTVEMLEKKRKKKKIRMMQ", "length": 392, "header": "sp|Q5EA99-1|PK1IP_BOVIN Isoform 1 of p21-activated protein kinase-interacting protein 1 OS=Bos taurus OX=9913 GN=PAK1IP1 PE=2 SV=1 CANONICAL=Q5EA99-1" }, "isoforms": [ { "isoform_ac": "Q5EA99-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA99/entry#Q5EA99-1", "sequence": { "sequence": "MEVVAGCYEQVLFGFAVHPEPVGDGHRERWAPVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKVDHGALMHHNGTITCLKFHGNRHLISGAEDGLICVWDARRWECLKSIRAHKGHVTFLSIHPSGRLALSVGTDKTLRTWNLVEGRSAFIKNIKQSAHIVEWSPKGEKYVVVILNRIDVYQLDTASVSGTITNERRVSSVTFLSESVLTVAGDEEVVRFFDCDSLTCLSEFKAHENRVKDMFSFETPEHHVLVTASSDGFIKMWKLKQDKKVSPSLLCEINTNARLTCLGVWLDRRTDTKESPPAAAEPAPVSKEQSRRNKEESGHAVQEEEKQPKPDTEKCSLTGDSNKPTRGNSLVSAKKRKTVEMLEKKRKKKKIRMMQ", "length": 392, "header": "sp|Q5EA99-1|PK1IP_BOVIN Isoform 1 of p21-activated protein kinase-interacting protein 1 OS=Bos taurus OX=9913 GN=PAK1IP1 PE=2 SV=1 CANONICAL=Q5EA99-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505125", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505125", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" }, { "name": "regulation of signal transduction by p53 class mediator", "id": "GO:1901796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" }, { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000463", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase inhibitor activity", "id": "GO:0004860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004860", "evidence": [ { "database": "UniProtKB", "id": "Q5EA99", "url": "https://www.uniprot.org/uniprotkb/Q5EA99" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA99-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 392, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA99-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA99" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAA4-1", "uniprot_ac": "Q5EAA4", "uniprot_id": "MOB3C_BOVIN", "mass": { "chemical_mass": 25655.0, "monoisotopic_mass": 25655.0 }, "refseq": { "ac": "NP_001029927", "name": "MOB kinase activator 3C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" }, "gene_names": [ { "name": "MOB3C", "type": "recommended", "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ] }, { "name": "MOB3C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" } ] }, { "name": "MOBKL2C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" }, { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ] } ], "protein_names": [ { "name": "MOB kinase activator 3C", "type": "recommended", "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4/entry#names_and_taxonomy" } ] }, { "name": "MOB kinase activator 3C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" } ] }, { "name": "MOB1, Mps One Binder kinase activator-like 2C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" } ] }, { "name": "Mob1 homolog 2C", "type": "synonym", "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4/entry#names_and_taxonomy" } ] }, { "name": "Mps one binder kinase activator-like 2C", "type": "synonym", "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4/entry#names_and_taxonomy" } ] }, { "name": "mob1 homolog 2C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" } ] }, { "name": "mps one binder kinase activator-like 2C", "type": "synonym", "evidence": [ { "id": "NP_001029927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927" } ] } ], "function": [ { "annotation": "May regulate the activity of kinases.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOB3C", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4", "locus": { "chromosome": "3", "start_pos": 99523394, "end_pos": 99514846, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023551", "url": "https://www.ensembl.org/id/ENSBTAG00000023551" } ] } } ], "crossref": [ { "id": "Q5EAA4", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023551", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023551", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614275", "url": "https://www.ncbi.nlm.nih.gov/gene/614275", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614275", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614275", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AEHCSET", "url": "https://omabrowser.org/oma/group/AEHCSET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAA4", "url": "https://www.orthodb.org/?gene=Q5EAA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029927", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAA4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALCLKQVFSKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIESLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH", "length": 216, "header": "sp|Q5EAA4-1|MOB3C_BOVIN Isoform 1 of MOB kinase activator 3C OS=Bos taurus OX=9913 GN=MOB3C PE=2 SV=1 CANONICAL=Q5EAA4-1" }, "isoforms": [ { "isoform_ac": "Q5EAA4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4/entry#Q5EAA4-1", "sequence": { "sequence": "MALCLKQVFSKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIESLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH", "length": 216, "header": "sp|Q5EAA4-1|MOB3C_BOVIN Isoform 1 of MOB kinase activator 3C OS=Bos taurus OX=9913 GN=MOB3C PE=2 SV=1 CANONICAL=Q5EAA4-1" }, "locus": { "chromosome": "3", "start_pos": 99521410, "end_pos": 99518475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032168.3", "url": "https://www.ensembl.org/id/ENSBTAT00000032168.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032106.1", "url": "https://www.ensembl.org/id/ENSBTAP00000032106.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614275", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614275", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W4X2-1", "protein_name": "MOB kinase activator 3C", "gene_name": "MOB3C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZP72-1", "protein_name": "MOB kinase activator 3C", "gene_name": "Mob3c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRRVVRLPPGESIDDWIAVHVVDFFNRINLIYGTMAEHCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIQEFSLVDQRELEPLREMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GYU6-1", "protein_name": "MOB kinase activator 3C", "gene_name": "Mob3c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGESIDDWIAVHVVDFFNRINLIYGTMAEHCSEASCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIQEFSLVDQRELEPLREMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54BM4-1", "protein_name": "MOB kinase activator-like 1 homolog C", "gene_name": "mobC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFKIFGSKAQTFKPKKSIKKGTKQYELHQKIKETLGSGDLTDAIKLPPDETLFEWLSVNTIDFFNQSNLLYGSITEFCTPKYCPSMSAGPQYEFLWADGKEIKKPIRVSAPAYVDYLMTWIQVQLDDEDIFPTKPTEDMPKNFLPTIKAIFKRLFRVYAHIYYSHMDRVSVLGVEAHLNTAFRHFYLFIKEFNLVDKKEMLPLQNIIDKINARKDI", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q70IA8-1", "protein_name": "MOB kinase activator 3C", "gene_name": "MOB3C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEEVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BJG4-1", "protein_name": "MOB kinase activator 3C", "gene_name": "Mob3c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGESIDDWIAVHVVDFFNRINLIYGTMAEHCSESSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIQEFSLVDQRELEPLREMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "R4GHU8-1", "protein_name": "MOB kinase activator 3C", "gene_name": "MOB3C", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALCLKQVFNKDKTFRPRKKFEPGTQRFELYKKAQASLKSGLDLKAVVQLPPGESINDWIAVHVVDFFNRINLIYGTMSEYCTEKSCPIMSGGLKYEYRWQDDSKYKKPTKLSAPQYMCMLMDWIEMLINNEDIFPTRIGVPFPKQFQQVCTKILTRLFRVFVHVYIHHFDSIINMGAEAHVNTCYKHFYYFIREFSLVDHRELEPLKEMTERICH", "length": 216 }, "evidence": [ { "id": "Q5EAA4", "url": "https://omabrowser.org/oma/group/Q5EAA4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA4", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 216, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAA4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4#function" }, { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "binding_site_uniprot": 164, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 164, "end_pos": 164, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4#function" }, { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "binding_site_uniprot": 169, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 169, "end_pos": 169, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4#function" }, { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "binding_site_uniprot": 82, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 82, "end_pos": 82, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4#function" }, { "id": "Q5EAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA4" } ], "binding_site_uniprot": 87, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 87, "end_pos": 87, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAA5-1", "uniprot_ac": "Q5EAA5", "uniprot_id": "TCTA_BOVIN", "mass": { "chemical_mass": 11615.0, "monoisotopic_mass": 11615.0 }, "refseq": { "ac": "NP_001029961", "name": "T-cell leukemia translocation-altered gene protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029961" }, "gene_names": [ { "name": "TCTA", "type": "recommended", "evidence": [ { "id": "Q5EAA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5" } ] }, { "name": "TCTA", "type": "synonym", "evidence": [ { "id": "NP_001029961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029961" } ] } ], "protein_names": [ { "name": "T-cell leukemia translocation-altered gene protein homolog", "type": "recommended", "evidence": [ { "id": "Q5EAA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5/entry#names_and_taxonomy" } ] }, { "name": "T-cell leukemia translocation-altered gene protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001029961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029961" } ] } ], "function": [ { "annotation": "May be required for cellular fusion during osteoclastogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCTA", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5", "locus": { "chromosome": "22", "start_pos": 50697897, "end_pos": 50700975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022632", "url": "https://www.ensembl.org/id/ENSBTAG00000022632" } ] } } ], "crossref": [ { "id": "Q5EAA5", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616169", "url": "https://www.ncbi.nlm.nih.gov/gene/616169", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616169", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616169", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMWESTS", "url": "https://omabrowser.org/oma/group/SMWESTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAA5", "url": "https://www.orthodb.org/?gene=Q5EAA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32267:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32267:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15128", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15128", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029961", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAA5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPWSGQSLQALPATVLGALGALGSEFLREWEAQDMRVTLFKLLLFWLVLSLLSIQLAWGFYGSTVTGLYHRPGLGGQNGSTPDGSTHFPSWETAANEPLKTHRE", "length": 106, "header": "sp|Q5EAA5-1|TCTA_BOVIN Isoform 1 of T-cell leukemia translocation-altered gene protein homolog OS=Bos taurus OX=9913 GN=TCTA PE=3 SV=1 CANONICAL=Q5EAA5-1" }, "isoforms": [ { "isoform_ac": "Q5EAA5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5/entry#Q5EAA5-1", "sequence": { "sequence": "MAEPWSGQSLQALPATVLGALGALGSEFLREWEAQDMRVTLFKLLLFWLVLSLLSIQLAWGFYGSTVTGLYHRPGLGGQNGSTPDGSTHFPSWETAANEPLKTHRE", "length": 106, "header": "sp|Q5EAA5-1|TCTA_BOVIN Isoform 1 of T-cell leukemia translocation-altered gene protein homolog OS=Bos taurus OX=9913 GN=TCTA PE=3 SV=1 CANONICAL=Q5EAA5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616169", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616169", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SSR7-1", "protein_name": "T-cell leukemia translocation-altered gene protein homolog", "gene_name": "TCTA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEPWSGQSLQVLPATVLGALGALGSEFLREWEAQDMRVTLFKLLLLWLVLSLLSIQLAWGFYGSTVTGLYHRPGLGSQNGSTPDGSTHFSSWETAANEPLKTHRE", "length": 106 }, "evidence": [ { "id": "Q5EAA5", "url": "https://omabrowser.org/oma/group/Q5EAA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7G1H1-1", "protein_name": "T-cell leukemia translocation-altered gene protein isoform X1", "gene_name": "Tcta", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEPWSGQFLQALPASVLGALGTLGSEFLREWETQDMRVTLFKLLLLWLVLSLLGIQLAWGFYGNTVTGLYHRPGKWQQMNLSKPTENKGRQQQKRLQRHNWDCWLLGCILLLPRPVGQLQRAWGWGTGVPQCFQGEPPLLSALPSTAPGTGQVKSVSTPV", "length": 161 }, "evidence": [ { "id": "Q5EAA5", "url": "https://omabrowser.org/oma/group/Q5EAA5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P57738-1", "protein_name": "T-cell leukemia translocation-altered gene protein", "gene_name": "TCTA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESWSGQALQALPATVLGALGSEFLREWEAQDMRVTLFKLLLLWLVLSLLGIQLAWGFYGNTVTGLYHRPGLGGQNGSTPDGSTHFPSWEMAANEPLKTHRE", "length": 103 }, "evidence": [ { "id": "Q5EAA5", "url": "https://omabrowser.org/oma/group/Q5EAA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6DGY3-1", "protein_name": "T-cell leukemia translocation-altered gene protein homolog", "gene_name": "tcta", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEESWDFEFLSRMVDSLVSFLSEFVDDWLANDMRVAVFKILFSWLVVSLVAIHFAWKVYGNTVNDMYYRQGTGGQNGGTPDTHLSGWESAAGDAMKTHRE", "length": 100 }, "evidence": [ { "id": "Q5EAA5", "url": "https://omabrowser.org/oma/group/Q5EAA5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8VEA7-1", "protein_name": "T-cell leukemia translocation-altered gene protein homolog", "gene_name": "Tcta", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEPWAGQFLQALPATVLGALGTLGSDFLREWETQDMRVTLFKLLLLWLVLSLLGIQLAWGFYGNTVTGLYHRPDPHPQPPAAMGVFLPPGLGGQNGSTPDGSTHFSSWEIAANEALKTHRE", "length": 122 }, "evidence": [ { "id": "Q5EAA5", "url": "https://omabrowser.org/oma/group/Q5EAA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "osteoclast fusion", "id": "GO:0072675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072675", "evidence": [ { "database": "UniProtKB", "id": "Q5EAA5", "url": "https://www.uniprot.org/uniprotkb/Q5EAA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 106, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAA5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAE3-1", "uniprot_ac": "Q5EAE3", "uniprot_id": "UBTD2_BOVIN", "mass": { "chemical_mass": 26244.0, "monoisotopic_mass": 26244.0 }, "refseq": { "ac": "NP_001015679", "name": "ubiquitin domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679" }, "gene_names": [ { "name": "UBTD2", "type": "recommended", "evidence": [ { "id": "Q5EAE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3" } ] }, { "name": "DC-UbP", "type": "synonym", "evidence": [ { "id": "NP_001015679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679" } ] }, { "name": "UBTD2", "type": "synonym", "evidence": [ { "id": "NP_001015679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679" } ] } ], "protein_names": [ { "name": "Ubiquitin domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q5EAE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3/entry#names_and_taxonomy" } ] }, { "name": "dendritic cell-derived ubiquitin-like protein", "type": "synonym", "evidence": [ { "id": "NP_001015679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679" } ] }, { "name": "ubiquitin domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001015679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAE3", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBTD2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3", "locus": { "chromosome": "20", "start_pos": 3997791, "end_pos": 4064147, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034659", "url": "https://www.ensembl.org/id/ENSBTAG00000034659" } ] } } ], "crossref": [ { "id": "Q5EAE3", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541134", "url": "https://www.ncbi.nlm.nih.gov/gene/541134", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q5EAE3", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q5EAE3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541134", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541134", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GTGGECQ", "url": "https://omabrowser.org/oma/group/GTGGECQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAE3", "url": "https://www.orthodb.org/?gene=Q5EAE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAE3", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAE3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYESQLRLRLSTGKDLKLVVRSTDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMRLEELKIPKDYVVQVIMSQPLQNPTPVEN", "length": 234, "header": "sp|Q5EAE3-1|UBTD2_BOVIN Isoform 1 of Ubiquitin domain-containing protein 2 OS=Bos taurus OX=9913 GN=UBTD2 PE=2 SV=1 CANONICAL=Q5EAE3-1" }, "isoforms": [ { "isoform_ac": "Q5EAE3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3/entry#Q5EAE3-1", "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYESQLRLRLSTGKDLKLVVRSTDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMRLEELKIPKDYVVQVIMSQPLQNPTPVEN", "length": 234, "header": "sp|Q5EAE3-1|UBTD2_BOVIN Isoform 1 of Ubiquitin domain-containing protein 2 OS=Bos taurus OX=9913 GN=UBTD2 PE=2 SV=1 CANONICAL=Q5EAE3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541134", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541134", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P5V6-1", "protein_name": "Ubiquitin domain containing 2", "gene_name": "UBTD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGCVGSHHDSSGSLNENSDGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKGDLETLDIPDPPPNSGHECQLRLRLSTGKDLKLMVRSMDTVYHMKRRLHAVEGVEPGSQRWFFSGRPLADKMKLEELKIPKDYVVQVIVSQPLANPTPVEN", "length": 234 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LVF9-1", "protein_name": "Ubiquitin domain containing 2", "gene_name": "Ubtd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSDGTGGLDLPIRSAGLAVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPSSGHESQLRLRLSTGKDLKLVVRSTDTVFHMKRRLHATEGVEPGSQRWFFSGRPLTDKMKLEELKIPKDYVVQVIVSQPVQNPAPVEN", "length": 246 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LIF4-1", "protein_name": "Ubiquitin domain containing 2", "gene_name": "UBTD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPDPPPNSGYESQLRLRLSTGKDLKLVVRSTDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMKLEELKIPKDYVVQVIMSQPLQSPTPVEN", "length": 234 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6DG43-1", "protein_name": "Ubiquitin domain-containing protein 2", "gene_name": "ubtd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGGCVGSHHDSSGSLNENSDGTGVALGRNQPLKREKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAQAFESNDHELAQAIIDGASITLPHGALTECYDELGNRYQLPVYCLSPPVNMIEEKSESETIEVPEAPASEGQECQLRLRLSTGRDLRLAVRTSDSVQQMKRRLQTQEGVAATSQRWFFSGRPLTDKMKLEELKISRDYVVQVIVSQPPTTPPLPQNPTPVEN", "length": 240 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6PGH0-1", "protein_name": "Ubiquitin domain-containing protein 2", "gene_name": "Ubtd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSDGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGHESQLRLRLSTGKDLRLVVRSTDTVFHMKRRLHATEGVEPGSQRWFFSGRPLTDKMKLEELKIPKDYVVQVIVSQPVQTPTPVEN", "length": 234 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WUN7-1", "protein_name": "Ubiquitin domain-containing protein 2", "gene_name": "UBTD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYECQLRLRLSTGKDLKLVVRSTDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEELKIPKDYVVQVIVSQPVQNPTPVEN", "length": 234 }, "evidence": [ { "id": "Q5EAE3", "url": "https://omabrowser.org/oma/group/Q5EAE3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE3", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAE3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAE3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAE3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EAE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE3" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 152, "end_pos": 227, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6PX77-1", "uniprot_ac": "Q6PX77", "uniprot_id": "BMP15_BOVIN", "mass": { "chemical_mass": 45025.0, "monoisotopic_mass": 45025.0 }, "refseq": { "ac": "NP_001026922", "name": "bone morphogenetic protein 15 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, "gene_names": [ { "name": "BMP15", "type": "recommended", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ] }, { "name": "BMP15", "type": "synonym", "evidence": [ { "id": "NP_001026922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ] }, { "name": "bmp-15", "type": "synonym", "evidence": [ { "id": "NP_001026922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ] } ], "protein_names": [ { "name": "Bone morphogenetic protein 15", "type": "recommended", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77/entry#names_and_taxonomy" } ] }, { "name": "BMP-15", "type": "synonym", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77/entry#names_and_taxonomy" } ] }, { "name": "bone morphogenetic protein 15 precursor", "type": "synonym", "evidence": [ { "id": "NP_001026922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ] } ], "function": [ { "annotation": "BMP15 expression in the oocytes of calf and adult ovaries was not significantly different. BMP15 transcripts were detected in ovarian tissues, but were not detected in any other tissues examined by RT-PCR. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "21401961", "url": "https://glygen.org/publication/PubMed/21401961" } ] }, { "annotation": "Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows.", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "30548943", "url": "https://glygen.org/publication/PubMed/30548943" } ] }, { "annotation": "Immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "19439562", "url": "https://glygen.org/publication/PubMed/19439562" } ] }, { "annotation": "In conclusion, BMP-15 should be considered as a potential genetic marker for sperm quality, based on its association with fresh sperm motility. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "24668668", "url": "https://glygen.org/publication/PubMed/24668668" } ] }, { "annotation": "Maternal BMP15 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "15189828", "url": "https://glygen.org/publication/PubMed/15189828" } ] }, { "annotation": "May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77#function" } ] }, { "annotation": "Oocytes maintain complex integrity by preventing granulosa cell differentiation and participate in follicular antrum formation via GDF9 and BMP15", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "30033985", "url": "https://glygen.org/publication/PubMed/30033985" } ] }, { "annotation": "Polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "19433911", "url": "https://glygen.org/publication/PubMed/19433911" } ] }, { "annotation": "This study concluded that the improved pregnancy rate after porcine LH-induced ovulation reported previously occurred through greater activation of intrafollicular transforming growth factor-beta1 superfamily members, as these proteins promote cumulus expansion and oocyte competence.", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" }, { "database": "PubMed", "id": "26794084", "url": "https://glygen.org/publication/PubMed/26794084" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BMP15", "url": "https://www.uniprot.org/uniprotkb/Q6PX77", "locus": { "chromosome": "X", "start_pos": 88811597, "end_pos": 88803745, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045782", "url": "https://www.ensembl.org/id/ENSBTAG00000045782" } ] } } ], "crossref": [ { "id": "Q6PX77", "url": "https://alphafold.ebi.ac.uk/entry/Q6PX77", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045782", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045782", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19402", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19402", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "353351", "url": "https://www.ncbi.nlm.nih.gov/gene/353351", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:353351", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353351", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYRHQLH", "url": "https://omabrowser.org/oma/group/VYRHQLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6PX77", "url": "https://www.orthodb.org/?gene=Q6PX77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6PX77-1", "url": "https://www.uniprot.org/uniprotkb/Q6PX77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLSILRILLLWGLVLFMEHRVQMTQVGQPSIAHLPEAPTLPLIQELLEEAPGKQQRKPRILGHPLRYMLELYQRSADASGHPRENRTIGATMVRLVRPLASVARPLRGSWHIQTLDFPLRPNRVAYQLVRATVVYRHQLHLTHSHLSCHVEPWVQKSPTNHFPSSGRGSSKPSLLPKAWTEMDIMEHVGQKLWNHKGRRVLRLRFVCQQPRGSEVREFWWHGTSSLDTVFLLLYFNDTQSVQKTKPLPKGLKEFTEKDPSLLLRRARQAGSIASEVPGPSREHDGPESNLCSLHPFQVSFQQLGWDHWIIAPHLYTPNYCKGVCPRVLHYGLNSPNHAIIQNLVNELVDQSVPQPSCVPYKYVPISILLIEANGSILYKEYEGMIAQSCTCR", "length": 394, "header": "sp|Q6PX77-1|BMP15_BOVIN Isoform 1 of Bone morphogenetic protein 15 OS=Bos taurus OX=9913 GN=BMP15 PE=2 SV=1 CANONICAL=Q6PX77-1" }, "isoforms": [ { "isoform_ac": "Q6PX77-1", "url": "https://www.uniprot.org/uniprotkb/Q6PX77/entry#Q6PX77-1", "sequence": { "sequence": "MVLLSILRILLLWGLVLFMEHRVQMTQVGQPSIAHLPEAPTLPLIQELLEEAPGKQQRKPRILGHPLRYMLELYQRSADASGHPRENRTIGATMVRLVRPLASVARPLRGSWHIQTLDFPLRPNRVAYQLVRATVVYRHQLHLTHSHLSCHVEPWVQKSPTNHFPSSGRGSSKPSLLPKAWTEMDIMEHVGQKLWNHKGRRVLRLRFVCQQPRGSEVREFWWHGTSSLDTVFLLLYFNDTQSVQKTKPLPKGLKEFTEKDPSLLLRRARQAGSIASEVPGPSREHDGPESNLCSLHPFQVSFQQLGWDHWIIAPHLYTPNYCKGVCPRVLHYGLNSPNHAIIQNLVNELVDQSVPQPSCVPYKYVPISILLIEANGSILYKEYEGMIAQSCTCR", "length": 394, "header": "sp|Q6PX77-1|BMP15_BOVIN Isoform 1 of Bone morphogenetic protein 15 OS=Bos taurus OX=9913 GN=BMP15 PE=2 SV=1 CANONICAL=Q6PX77-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 238, "start_aa": "Asn", "end_pos": 238, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn238", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 375, "start_aa": "Asn", "end_pos": 375, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn375", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 87, "start_aa": "Asn", "end_pos": 87, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn87", "evidence": [ { "id": "Q6PX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6PX77#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15, and VASA in adult bovine tissues, oocytes, and preimplantation embryos.", "journal": "Biol. Reprod.", "date": "2004", "authors": "Pennetier Sophie, Uzbekova Svetlana, Perreau Christine, Papillier Pascal, Mermillod Pascal, Dalbi\u00e8s-Tran Rozenn", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" }, { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "15189828", "url": "https://glygen.org/publication/PubMed/15189828" } ] }, { "title": "Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15).", "journal": "Journal of applied genetics", "date": "2009", "authors": "Zhang L-P, Gan Q-F, Zhang X-H, Li H-D, Hou G-Y, Li J-Y, Gao X, Ren H-Y, Chen J-B, Xu S-Z", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "19433911", "url": "https://glygen.org/publication/PubMed/19433911" } ] }, { "title": "Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle.", "journal": "Reproduction (Cambridge, England)", "date": "2009-07", "authors": "Juengel Jennifer L, Hudson Norma L, Berg Martin, Hamel Keith, Smith Peter, Lawrence Stephen B, Whiting Lynda, McNatty Kenneth P", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "19439562", "url": "https://glygen.org/publication/PubMed/19439562" } ] }, { "title": "Quantitative analysis of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) gene expression in calf and adult bovine ovaries.", "journal": "Reproductive biology and endocrinology : RB&E", "date": "2011-03-15", "authors": "Hosoe Misa, Kaneyama Kanako, Ushizawa Koichi, Hayashi Ken-Go, Takahashi Toru", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "21401961", "url": "https://glygen.org/publication/PubMed/21401961" } ] }, { "title": "Polymorphisms in the bone morphogenetic protein 15 gene and their effect on sperm quality traits in Chinese Holstein bulls.", "journal": "Genetics and molecular research : GMR", "date": "2014-03-17", "authors": "Sun L P, Song Y P, Du Q Z, Song L W, Tian Y Z, Zhang S L, Hua G H, Yang L G", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "24668668", "url": "https://glygen.org/publication/PubMed/24668668" } ] }, { "title": "Alterations in bone morphogenetic protein 15, growth differentiation factor 9, and gene expression in granulosa cells in preovulatory follicles of dairy cows given porcine LH.", "journal": "Theriogenology", "date": "2016-04-15", "authors": "Behrouzi Amir, Colazo Marcos Germ\u00e1n, Ambrose Divakar Justus", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "26794084", "url": "https://glygen.org/publication/PubMed/26794084" } ] }, { "title": "GDF9 and BMP15 induce development of antrum-like structures by bovine granulosa cells without oocytes.", "journal": "The Journal of reproduction and development", "date": "2018-10-12", "authors": "Alam Md Hasanur, Lee Jibak, Miyano Takashi", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "30033985", "url": "https://glygen.org/publication/PubMed/30033985" } ] }, { "title": "Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows.", "journal": "Molecular reproduction and development", "date": "2019-02", "authors": "Vel\u00e1squez Alejandra, Mellisho Edwin, Castro Fidel Ovidio, Rodr\u00edguez-\u00c1lvarez Lleretny", "evidence": [ { "database": "RefSeq", "id": "NP_001026922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026922" } ], "reference": [ { "type": "PubMed", "id": "30548943", "url": "https://glygen.org/publication/PubMed/30548943" } ] } ], "pathway": [ { "id": "bta:353351", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353351", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H225-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "Bmp15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALLTILKILFWGMVFFMEHRVQMAKAGWPSITRLADDPTLPLNLDLAKEASGKEMKPRPQGYPLRYMLKLYQRSADLHGHPRENRTIGAKMVRLVKPSANVVRPLRGPWHVQILDFPLTSNQVAYQLIRATVVYRHQLHLVHYHLSCHVEPWIPKCLAKHFPSSEAGSSKLPPMSKAWTEMDITHCVQQRLWNRKGRRILRLRFMCQQQKGSEVLEFQWHGMSSLDVAFLLLYFNDTDRSVQAKLLAQGQEELTDRESSVLMRSARQACSIASDVPCHSQEHDGSINNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGFCSRVLPYGLNSPNHAIIQSLVNELVNHSVPQPSCVPYKFLPMSILLVEANGSILYKEYEGMIAQSCTCR", "length": 392 }, "evidence": [ { "id": "Q6PX77", "url": "https://omabrowser.org/oma/group/Q6PX77/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9PTU9-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "Bmp15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLTILRILLWGMVLFMEHKVQMAKVEWPSTTLLAENPTLPSSLDLAKEAPGKEMKQWPQGYPLRYMLKLYQRSADPHGHPRENRTIGAKMVRLIKPSASAMRLLRGPWHIQTLDFPLASNEVAYQLIRATVVYRHQLHLVHYHLSCHVEPWVPKCRTKHFPSKSGSAKPSSVSKAWREMNITHCIQQKLWNRKGRRVLRLRFMCQQQKGNETLELRWHGMTSLDVAFLLLYFNDTDESAQAKLLARGQEELTDRESPFLMRSVRQTCSIASDVPCPSQEQDRSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTGVLPYGLNSPNHAIIQSLVNELVNRSVPQLSCVPYKFLPMSILLIEANGSILYKEYEGMIAQSCTCR", "length": 391 }, "evidence": [ { "id": "Q6PX77", "url": "https://omabrowser.org/oma/group/Q6PX77/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RV73-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLNKSFKMVLLSIIRTLLLWGLVLFMEHRVQMTQVGQPSVALLPEACTLPLIRELLEEAPGKQQRKPQVLGHPLRYMLELYQRSADARGHPRENRTIGATMVRLVRPLVNGARPLRGPWHIQTLDFPLRPNRVAYQLVRATVVYRHQLHLAPFHLSCHVEPWIQKSTTSHFPSSGRGSLKPSLLPQAWTEMDVTQHVGQKLWNHKGRRVLRLRFMCQQQNGSEILEFRGRGISSLDTAFLLLYFNDTRSVQKAKLLPRGLEEFMARDPSLLLRKARQAGSIASEVLGPSREHDGPESNQCSLHPFQVSFHQLGWDHWIIAPHFYTPNYCKGVCPRVLHYGLNSPNHAIIQNLVNELVDQSVPQPSCVPYKYVPISILLIEANGSILYKEYEDMIAQSCTCR", "length": 402 }, "evidence": [ { "id": "Q6PX77", "url": "https://omabrowser.org/oma/group/Q6PX77/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR", "length": 392 }, "evidence": [ { "id": "Q6PX77", "url": "https://omabrowser.org/oma/group/Q6PX77/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0L4-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "Bmp15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALLTILRILLWGVVLFMEQRVQMAKPGWPSTALLADDPTLPSILDLAKEAPGKEMKQWPQGYPLRYMLKLYHRSADPHGHPRENRTIGAKMVRLVKPSANTVRPPRGSWHVQTLDFPLASNQVAYELIRATVVYRHQLHLVNYHLSCHVETWVPKCRTKHLPSSKSGSSKPSPMSKAWTEIDITHCIQQKLWNRKGRSVLRLRFMCQQQKGNETREFRWHGMTSLDVAFLLLYFNDTDDRVQGKLLARGQEELTDRESSFLMRSVRQACSIESDASCPSQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTRVLPYGLNSPNHAIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGMIAQSCTCR", "length": 392 }, "evidence": [ { "id": "Q6PX77", "url": "https://omabrowser.org/oma/group/Q6PX77/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor protein serine/threonine kinase signaling pathway", "id": "GO:0007178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007178", "evidence": [ { "database": "UniProtKB", "id": "Q6PX77", "url": "https://www.uniprot.org/uniprotkb/Q6PX77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6PX77-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6PX77-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6PX77" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 87, 238, 375 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6QRN8-1", "uniprot_ac": "Q6QRN8", "uniprot_id": "LAP4A_BOVIN", "mass": { "chemical_mass": 26820.0, "monoisotopic_mass": 26820.0 }, "refseq": { "ac": "NP_991368", "name": "lysosomal-associated transmembrane protein 4A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991368" }, "gene_names": [ { "name": "LAPTM4A", "type": "recommended", "evidence": [ { "id": "Q6QRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ] }, { "name": "LAPTM4A", "type": "synonym", "evidence": [ { "id": "NP_991368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991368" } ] } ], "protein_names": [ { "name": "Lysosomal-associated transmembrane protein 4A", "type": "recommended", "evidence": [ { "id": "Q6QRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8/entry#names_and_taxonomy" } ] }, { "name": "lysosomal-associated protein transmembrane 4 alpha", "type": "synonym", "evidence": [ { "id": "NP_991368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991368" } ] }, { "name": "lysosomal-associated transmembrane protein 4A", "type": "synonym", "evidence": [ { "id": "NP_991368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991368" } ] } ], "function": [ { "annotation": "May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.", "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAPTM4A", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8", "locus": { "chromosome": "11", "start_pos": 78814735, "end_pos": 78796769, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020894", "url": "https://www.ensembl.org/id/ENSBTAG00000020894" } ] } } ], "crossref": [ { "id": "Q6QRN8", "url": "https://alphafold.ebi.ac.uk/entry/Q6QRN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020894", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020894", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404135", "url": "https://www.ncbi.nlm.nih.gov/gene/404135", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404135", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404135", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCYKYII", "url": "https://omabrowser.org/oma/group/NCYKYII/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6QRN8", "url": "https://www.orthodb.org/?gene=Q6QRN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12479", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12479", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12479:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12479:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03821", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03821", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_991368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991368", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6QRN8-1", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNMPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYIPA", "length": 233, "header": "sp|Q6QRN8-1|LAP4A_BOVIN Isoform 1 of Lysosomal-associated transmembrane protein 4A OS=Bos taurus OX=9913 GN=LAPTM4A PE=2 SV=1 CANONICAL=Q6QRN8-1" }, "isoforms": [ { "isoform_ac": "Q6QRN8-1", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8/entry#Q6QRN8-1", "sequence": { "sequence": "MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNMPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYIPA", "length": 233, "header": "sp|Q6QRN8-1|LAP4A_BOVIN Isoform 1 of Lysosomal-associated transmembrane protein 4A OS=Bos taurus OX=9913 GN=LAPTM4A PE=2 SV=1 CANONICAL=Q6QRN8-1" }, "locus": { "chromosome": "11", "start_pos": 78814185, "end_pos": 78796892, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027837.3", "url": "https://www.ensembl.org/id/ENSBTAT00000027837.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000027837.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404135", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404135", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XV96-1", "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "LAPTM4A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVPAGPQEEAPQAPATDNTAPTATAGCLSAEVRAGSSSPRWRTPDSPYRTSPQVVNLLMGILLTVEVTHPNVVPTVNIQYEVIGNYYASERMAENACVLFAISLLMFTISAMMVYGAIAHRVGWLIPFFCYQLFDFVVSCLVAISSLTYLPRIKDYLDQLPDFPYKDDLLSLDSSCLLFIVLVFFALFIILKAYLINCVWNCYKYISNRNLPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYIPA", "length": 250 }, "evidence": [ { "id": "Q6QRN8", "url": "https://omabrowser.org/oma/group/Q6QRN8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LPB3-1", "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "LAPTM4A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSVPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNMPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYIPA", "length": 233 }, "evidence": [ { "id": "Q6QRN8", "url": "https://omabrowser.org/oma/group/Q6QRN8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15012-1", "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "LAPTM4A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA", "length": 233 }, "evidence": [ { "id": "Q6QRN8", "url": "https://omabrowser.org/oma/group/Q6QRN8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5TYX5-1", "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "laptm4a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFLQSTENDMRFKPSRDRLYSARCCGCCHVRTGTIILGTWYMVVNLLMGILLTVAVTHPENVPTVDLQYEVIEHYFASDRMSENACVGFAISLLMLTISAMMVYGAITNRDGWLIPFFCYQLFDFALSCLVAISSLTYLPRIKDYLDQLPDFPYKDNLLSLDSSCLLLFVLIFFAILIVLKAYLINCVWNCYKYINNRNTPEIAVYPAFETPPQYILPTYEMAMTMPAKEPPPPYMPA", "length": 238 }, "evidence": [ { "id": "Q6QRN8", "url": "https://omabrowser.org/oma/group/Q6QRN8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P501-1", "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "Laptm4a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFVVFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKIPEKEPPPPYLPA", "length": 233 }, "evidence": [ { "id": "Q6QRN8", "url": "https://omabrowser.org/oma/group/Q6QRN8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of lysosomal membrane permeability", "id": "GO:0097213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097213", "evidence": [ { "database": "UniProtKB", "id": "Q6QRN8", "url": "https://www.uniprot.org/uniprotkb/Q6QRN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6QRN8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 233, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6QRN8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6QRN8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6QTG5-1", "uniprot_ac": "Q6QTG5", "uniprot_id": "Q6QTG5_BOVIN", "mass": { "chemical_mass": 29846.0, "monoisotopic_mass": 29846.0 }, "refseq": { "ac": "YP_209211", "name": "cytochrome c oxidase subunit III", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209211" }, "gene_names": [ { "name": "COX3", "type": "recommended", "evidence": [ { "id": "Q6QTG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ] }, { "name": "COX3", "type": "synonym", "evidence": [ { "id": "YP_209211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209211" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase subunit 3", "type": "recommended", "evidence": [ { "id": "Q6QTG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5/entry#names_and_taxonomy" } ] }, { "name": "cytochrome c oxidase subunit III", "type": "synonym", "evidence": [ { "id": "YP_209211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209211" } ] } ], "function": [ { "annotation": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5#function" }, { "database": "UniProtKB", "id": "RU003375", "url": "https://www.uniprot.org/uniprotkb/RU003375#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COX3", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5", "locus": { "chromosome": "MT", "start_pos": 9750, "end_pos": 8970, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043560", "url": "https://www.ensembl.org/id/ENSBTAG00000043560" } ] } } ], "crossref": [ { "id": "ENSBTAG00000043560", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01665", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01665", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "3283883", "url": "https://www.ncbi.nlm.nih.gov/gene/3283883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035973", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035973", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:3283883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SIYWWGS", "url": "https://omabrowser.org/oma/group/SIYWWGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6QTG5", "url": "https://www.orthodb.org/?gene=Q6QTG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11403:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11403:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00510", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00510", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9707564", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "YP_209211", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209211", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11436", "url": "https://www.rhea-db.org/rhea/11436", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6QTG5-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG", "length": 260, "header": "tr|Q6QTG5-1|Q6QTG5_BOVIN Isoform 1 of Cytochrome c oxidase subunit 3 OS=Bos taurus OX=9913 GN=COX3 PE=3 SV=1 CANONICAL=Q6QTG5-1" }, "isoforms": [ { "isoform_ac": "Q6QTG5-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5/entry#Q6QTG5-1", "sequence": { "sequence": "MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG", "length": 260, "header": "tr|Q6QTG5-1|Q6QTG5_BOVIN Isoform 1 of Cytochrome c oxidase subunit 3 OS=Bos taurus OX=9913 GN=COX3 PE=3 SV=1 CANONICAL=Q6QTG5-1" }, "locus": { "chromosome": "Mitochondrion", "start_pos": 9749, "end_pos": 8970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000060566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000053157.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 109, "start_aa": "Thr", "end_pos": 109, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr109", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:3283883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283883", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-9707564", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "resource": "Reactome", "description": "Cytoprotection by HMOX1" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "P00414-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P00416-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "mt-Co3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLTLGLLTNILTMYQWWRDVIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMNQALLITIMLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00417-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "mt:CoIII", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTHSNHPFHLVDYSPWPLTGAIGAMTTVSGMVKWFHQYDISLFVLGNIITILTVYQWWRDVSREGTYQGLHTYAVTIGLRWGMILFILSEVLFFVSFFWAFFHSSLSPAIELGASWPPMGIISFNPFQIPLLNTAILLASGVTVTWAHHSLMENNHSQTTQGLFFTVLLGIYFTILQAYEYIEAPFTIADSIYGSTFFMATGFHGIHVLIGTTFLLVCLLRHLNNHFSKNHHFGFEAAAWYWHFVDVVWLFLYITIYWWGG", "length": 262 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P00420-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "COX3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTHLERSRHQQHPFHMVMPSPWPIVVSFALLSLALSTALTMHGYIGNMNMVYLALFVLLTSSILWFRDIVAEATYLGDHTMAVRKGINLGFLMFVLSEVLIFAGLFWAYFHSAMSPDVTLGACWPPVGIEAVQPTELPLLNTIILLSSGATVTYSHHALIAGNRNKALSGLLITFWLIVIFVTCQYIEYTNAAFTISDGVYGSVFYAGTGLHFLHMVMLAAMLGVNYWRMRNYHLTAGHHVGYETTIIYTHVLDVIWLFLYVVFYWWGV", "length": 269 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P05505-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "Mt-co3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P18945-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAHQAHSYHMVDPSPWPIFGAAAALLTTSGLIMWFHYSSTTLLTMGLLSMLLVMLQWWRDVVRESTFQGHHTPTVQKGLRYGMILFITSEAFFFLGFFWAFFHSSLAPTPELGGQWPPTGVKPLNPLEVPLLNTAILLASGVTVTWAHHSITEGNRKQAIHALTLTILLGFYFTALQAMEYHEASFSIADSVYGSTFFVATGFHGLHVIIGSSFLTVCLLRLIKFHFTPNHHFGFEAAAWYWHFVDIIWLFLYMSMYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P92514-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "COX3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIESQRHSYHLVDPSPWPISGSLGALATTVGGVMYMHSFQGGARLLSLGLIFILYTMFVWWRDVLRESTLEGHHTKVVQLGLRYGFILFIVSEVMFFFAFFWAFFHSSLAPAVEIGGIWPPKGIEVLDPWEIPFLNTLILLSSGAAVTWAHHAILAGKEKRAVYALVATVLLALVFTGFQGMEYYQAPFTISDSIYGSTFFLATGFHGFHVIIGTLFLIICGIRQYLGHLTKEHHVGFEAAAWYWHFVDVVWLFLFVSIYWWGGI", "length": 265 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q35916-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMLLLSLGLLTNTLTMYQWWRDIIRESTFQGHHTSVVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSILLASGVSITWAHHSLMEGDRKHMIQALSITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9MIY4-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "mt-co3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAHQAHAYHMVDPSPWPLTGAVAALLMSSGLAIWFHLHSMTLIVLGMILLILTMIQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGCWPPTGLTTLDPFEVPLLNTAVLLASGVTVTWAHHSLMEGERKQAIQSLALTILLGLYFTALQAMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQVLFHFTSDHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS", "length": 261 }, "evidence": [ { "id": "Q6QTG5", "url": "https://omabrowser.org/oma/group/Q6QTG5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" }, { "name": "respiratory chain complex IV", "id": "GO:0045277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045277", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial electron transport, cytochrome c to oxygen", "id": "GO:0006123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006123", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" }, { "name": "respiratory chain complex IV assembly", "id": "GO:0008535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008535", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytochrome-c oxidase activity", "id": "GO:0004129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004129", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG5", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11436", "name": "", "equation": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00396-1", "P00415-1", "P68530-1", "Q6QTG9-1" ], "evidence": [ { "id": "11436", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11436" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P00396", "gene_name": "MT-CO1", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "P00396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00396" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "P00396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00396" } ] } ] }, { "uniprot_ac": "P00415", "gene_name": "MT-CO3", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "P00415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00415" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "P00415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00415" } ] } ] }, { "uniprot_ac": "P68530", "gene_name": "MT-CO2", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] } ] }, { "uniprot_ac": "Q6QTG9", "gene_name": "COX1", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "Q6QTG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "Q6QTG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q6QTG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTG5" }, { "id": "PS50253", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50253" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Heme-copper oxidase subunit III family profile", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 260, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 109 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6QTH1-1", "uniprot_ac": "Q6QTH1", "uniprot_id": "Q6QTH1_BOVIN", "mass": { "chemical_mass": 35656.0, "monoisotopic_mass": 35656.0 }, "refseq": { "ac": "YP_209205", "name": "NADH dehydrogenase subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209205" }, "gene_names": [ { "name": "ND1", "type": "recommended", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] }, { "name": "ND1", "type": "synonym", "evidence": [ { "id": "YP_209205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209205" } ] } ], "protein_names": [ { "name": "NADH-ubiquinone oxidoreductase chain 1", "type": "recommended", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1/entry#names_and_taxonomy" } ] }, { "name": "7.1.1.2", "type": "synonym", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase subunit 1", "type": "synonym", "evidence": [ { "id": "YP_209205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209205" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ND1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1", "locus": { "chromosome": "MT", "start_pos": 4056, "end_pos": 3101, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043558", "url": "https://www.ensembl.org/id/ENSBTAG00000043558" } ] } } ], "crossref": [ { "id": "ENSBTAG00000043558", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043558", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3283877", "url": "https://www.ncbi.nlm.nih.gov/gene/3283877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:3283877", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283877", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WSGWASN", "url": "https://omabrowser.org/oma/group/WSGWASN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6QTH1", "url": "https://www.orthodb.org/?gene=Q6QTH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11432", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11432", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11432:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11432:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "YP_209205", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6QTH1-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVVLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT", "length": 318, "header": "tr|Q6QTH1-1|Q6QTH1_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 1 OS=Bos taurus OX=9913 GN=ND1 PE=3 SV=1 CANONICAL=Q6QTH1-1" }, "isoforms": [ { "isoform_ac": "Q6QTH1-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1/entry#Q6QTH1-1", "sequence": { "sequence": "MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVVLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT", "length": 318, "header": "tr|Q6QTH1-1|Q6QTH1_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 1 OS=Bos taurus OX=9913 GN=ND1 PE=3 SV=1 CANONICAL=Q6QTH1-1" }, "locus": { "chromosome": "Mitochondrion", "start_pos": 4054, "end_pos": 3101, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000060571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053145.1", "url": "https://www.ensembl.org/id/ENSBTAP00000053145.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:3283877", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283877", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0U1RS44-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "MT-ND1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFMINILSLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADALKLVTKEPLRPGTSSISMFIIAPILGLSLALTMWVPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMNGSYTLSTLITTQEHIWMIFTSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFMAEYANIIMMNAFTAILFLGASHDPHTPELYTINFVLKTLALTITFLWIRASYPRFRYDQLMHLLWKSFLPLTLALCMWHISLPIMTASIPPQS", "length": 318 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P03886-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "MT-ND1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT", "length": 318 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P03888-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "Mtnd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYGILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGILFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSYSLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM", "length": 318 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P03889-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "Mt-nd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYFINILTLLIPILIAMAFLTLVERKILGYMQLRKGPNIVGPYGILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWIPLPMPHPLINLNLGMLFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMSGSFSLQMLITTQEHIWLLIPAWPMAMMWYISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIILMNALTSIVFLGPLYHINYPELYSTSFMTETLLLSTTFLWIRASYPRFRYDQLMHLLWKNFLPLTLAFCMWYISLPIFLAGIPPYT", "length": 318 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P18929-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "mt:ND1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEFILSLIGSLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGLMGIPQPFCDAIKLFTKEQTYPLLSNYLSYYISPIFSLFLSLFVWMCMPFFVKLYSFNLGGLFFLCCTSLGVYTVMVAGWSSNSNYALLGGLRAVAQTISYEVSLALILLSFIFLIGSYNMIYFFFYQVYMWFLIILFPMALVWMSISLAETNRTPFDFAEGESELVSGFNVEYSSGGFALIFMAEYASILFMSMLFCVIFLGCDVFNLLFYMKLTFISFVFIWVRGTLPRFRYDKLMYLAWKCFLSFSLNYLLFFIGFKILLFSLL", "length": 312 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P18936-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "MT-ND1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTLPTLTNLLIMTLSYILPILIAVAFLTLVERKILSYMQARKGPNIVGPFGLLQPVADGVKLFIKEPIRPSTSSPFLFIITPILALLLALTIWVPLPLPFPLADLNLGLLFLLAMSSLTVYSLLWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSTIMLSGNYTLSTLAITQEPIYLIFSAWPLAMMWYISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFLAEYANIMLMNTLTTVLFLNPSFLNLPPELFPIALATKTLLLSSSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCLWHTSMPISYAGLPPI", "length": 324 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q37165-1", "protein_name": "NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic", "gene_name": "ndhA", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIIYATAVQTINSFVKLESLKEVYGLIWIFVPIFSLVLGIITGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKENLRPSRGNTPLFSIGPSIAVISILLSYSVIPFSNHLVLADLNIGIFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVEAQSKYGFWGWNLWRQPIGFIIFLISSLAECERLPFDLPEAEEELIAGYQTEYSGIKFGLFYVASYLNLLISSLFVTVLYLGGWNISIPYISILELFQRDQIFGTTIGIFITLAKTYLFLFVSIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSFQLFSL", "length": 360 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q37313-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "nad1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENMLYIIIEGGLKSLIVIIGLLIGVAFATLLERKVMAAMQKRRGPNVVGFVGLLQPLADGLKLVLKETIIPIVADKLIYAIAPILTFTISIVLWSVIAVGVQSVFASINSGVIFILAISSIGVYGIILAGWASNSKYAFLGGLRSAAQMVSYEVALGLIILSIITYAGTVNLQEIMENQEKVWFIIPLLPGFLLAFISALTETNRPPFDLPEAEAELVSGYNVEYSSTGFALFFLGEYANIILMSVLLSVFFLGGIVSNKILGAMKGVGMLCSFIWVRATLPRYRYDQLMYLGWKSLLPFALLIYIGVISMVLIIK", "length": 317 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9MIZ0-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "mt-nd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLDILTSHLINPLAYAVPVLIAVAFLTLVERKVLGYMQLRKGPNVMGPRGLLQSVADGVKLFIKEPIRPSMASPILFLTAPVLALILAMMLWAPMPMPYPVLDLNLGILFIMAISSLAVYSILGSGWASNSKYALIGALRAVAQTISYEVSLGLILLSAVIFSGGYTLQTFNTTQEDTWLLLPLWPLAIMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFLAEYSNILLMNTHSTVLFLGASFTPDAPELMTISIATKTAMLSILFLWMRASYPRFRYDQLMHLIWKNFLPITLVLVLWHIALPIALAGLPPQT", "length": 324 }, "evidence": [ { "id": "Q6QTH1", "url": "https://omabrowser.org/oma/group/Q6QTH1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" }, { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTH1-1", "Q85BD6-1", "A0AAA9SEY3-1", "A0AAA9TZL3-1", "P03920-1", "P03887-1", "P03892-1", "P03898-1", "P03902-1", "P03910-1", "P03924-1", "P04394-1", "P15690-1", "P17694-1", "P23709-1", "P25708-1", "P42026-1", "P42028-1", "Q6QTH0-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] }, { "id": "R-BTA-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "P25708-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-163217", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163217" } ] }, { "id": "R-BTA-5419271", "name": "55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03898-1", "P03910-1", "P03902-1", "P68530-1", "Q6QTH1-1", "Q85BD6-1", "Q3T116-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-5419271", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419271" } ] }, { "id": "R-BTA-6799179", "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799179" } ] }, { "id": "R-BTA-6799191", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P42028-1", "Q6QTH1-1", "F1MJQ5-1" ], "evidence": [ { "id": "R-BTA-6799191", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799191" } ] }, { "id": "R-BTA-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799196", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799196" } ] }, { "id": "R-BTA-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799197", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799197" } ] }, { "id": "R-BTA-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03924-1", "P42028-1", "Q6QTH1-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799202" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MP25", "gene_name": "ACAD9", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] } ] }, { "uniprot_ac": "A0AAA9SEY3", "gene_name": "", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] } ] }, { "uniprot_ac": "A0AAA9TZL3", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] } ] }, { "uniprot_ac": "F1MJQ5", "gene_name": "NDUFAF7", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] } ] }, { "uniprot_ac": "P03887", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] } ] }, { "uniprot_ac": "P03892", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] } ] }, { "uniprot_ac": "P03898", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] } ] }, { "uniprot_ac": "P03902", "gene_name": "MT-ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] } ] }, { "uniprot_ac": "P03910", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] } ] }, { "uniprot_ac": "P03920", "gene_name": "MT-ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] } ] }, { "uniprot_ac": "P03924", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] } ] }, { "uniprot_ac": "P04394", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P17694", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] } ] }, { "uniprot_ac": "P23709", "gene_name": "NDUFS3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] } ] }, { "uniprot_ac": "P25708", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] } ] }, { "uniprot_ac": "P42026", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] } ] }, { "uniprot_ac": "P42028", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] } ] }, { "uniprot_ac": "P68530", "gene_name": "MT-CO2", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] } ] }, { "uniprot_ac": "Q3T116", "gene_name": "MRPL58", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] } ] }, { "uniprot_ac": "Q6QTH0", "gene_name": "ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] } ] }, { "uniprot_ac": "Q6QTH1", "gene_name": "ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] } ] }, { "uniprot_ac": "Q85BD6", "gene_name": "ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.1.1.2", "ec_name": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "7.1.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2" }, { "id": "7.1.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.1.1.2" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 258, "end_pos": 260 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6Y1E2-1", "uniprot_ac": "Q6Y1E2", "uniprot_id": "PLP2_BOVIN", "mass": { "chemical_mass": 16646.0, "monoisotopic_mass": 16646.0 }, "refseq": { "ac": "NP_976239", "name": "proteolipid protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976239" }, "gene_names": [ { "name": "PLP2", "type": "recommended", "evidence": [ { "id": "Q6Y1E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2" } ] }, { "name": "PLP2", "type": "synonym", "evidence": [ { "id": "NP_976239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976239" } ] } ], "protein_names": [ { "name": "Proteolipid protein 2", "type": "recommended", "evidence": [ { "id": "Q6Y1E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2/entry#names_and_taxonomy" } ] }, { "name": "proteolipid protein 2 (colonic epithelium-enriched)", "type": "synonym", "evidence": [ { "id": "NP_976239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976239" } ] }, { "name": "proteolipid protein 2", "type": "synonym", "evidence": [ { "id": "NP_976239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976239" } ] } ], "function": [ { "annotation": "May play a role in cell differentiation in the intestinal epithelium.", "evidence": [ { "database": "UniProtKB", "id": "Q6Y1E2", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2#function" }, { "database": "UniProtKB", "id": "A0ABI0NT83", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT83#function" }, { "database": "UniProtKB", "id": "ARBA00037152", "url": "https://www.uniprot.org/uniprotkb/ARBA00037152#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6Y1E2", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLP2", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2", "locus": { "chromosome": "X", "start_pos": 87219385, "end_pos": 87216328, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016093", "url": "https://www.ensembl.org/id/ENSBTAG00000016093" } ] } } ], "crossref": [ { "id": "Q6Y1E2", "url": "https://alphafold.ebi.ac.uk/entry/Q6Y1E2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016093", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016093", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "399683", "url": "https://www.ncbi.nlm.nih.gov/gene/399683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:399683", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:399683", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TNFWRTR", "url": "https://omabrowser.org/oma/group/TNFWRTR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6Y1E2", "url": "https://www.orthodb.org/?gene=Q6Y1E2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_976239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976239", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NT83", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NT83-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y1E2", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y1E2-1", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSERLTAPGCWAACTSFSRTRKGFLLFAEIILCLVILICFSTSTSGYSFLSVIEMIFAAIFFVVYMCDLHTKIQIINWPWSDFFRTLVAAILYLITSIVVLVERGNGSKIAAGALGLCAAGLFGYDAYITFPLRQQRHTAAPTDPADGPV", "length": 152, "header": "sp|Q6Y1E2-1|PLP2_BOVIN Isoform 1 of Proteolipid protein 2 OS=Bos taurus OX=9913 GN=PLP2 PE=2 SV=1 CANONICAL=Q6Y1E2-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NT83-1", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2/entry#A0ABI0NT83-1", "sequence": { "sequence": "MADSERLTAPGCWAACTSFSRTRKGFLLFAEIILCLVILICFSTSTSGYSFLSVIEMIFAAIFFVVYMCDLHTKIQIINWPWSDFFRTLVAAILYLITSIVVLVERGNGSKIAAGVKAVESASKHREKGLRILGLFLPLLLPESV", "length": 145, "header": "tr|A0ABI0NT83-1|A0ABI0NT83_BOVIN Computationally mapped isoform of Proteolipid protein 2 OS=Bos taurus OX=9913 GN=PLP2 PE=4 SV=1 CANONICAL=Q6Y1E2-1" }, "locus": { "chromosome": "X", "start_pos": 87218042, "end_pos": 87216431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136273.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136273.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106492.1" } ] } }, { "isoform_ac": "Q6Y1E2-1", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2/entry#Q6Y1E2-1", "sequence": { "sequence": "MADSERLTAPGCWAACTSFSRTRKGFLLFAEIILCLVILICFSTSTSGYSFLSVIEMIFAAIFFVVYMCDLHTKIQIINWPWSDFFRTLVAAILYLITSIVVLVERGNGSKIAAGALGLCAAGLFGYDAYITFPLRQQRHTAAPTDPADGPV", "length": 152, "header": "sp|Q6Y1E2-1|PLP2_BOVIN Isoform 1 of Proteolipid protein 2 OS=Bos taurus OX=9913 GN=PLP2 PE=2 SV=1 CANONICAL=Q6Y1E2-1" }, "locus": { "chromosome": "X", "start_pos": 87218998, "end_pos": 87216431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021425.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021425.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021425.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021425.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "Q6Y1E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:399683", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:399683", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZT52-1", "protein_name": "Proteolipid protein 2", "gene_name": "Plp2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSERLSAPGCWLACTSFSRSKKGILLFAEIILCLVILICFSASTSAYSSLLAIEMIFVAVLFVFYVCHLHSKISFISWPWTDFFRSLIAILYLITSIVVLVEGRGSSIFVAGVLGLLATLLFGYDAYITFPLKQQRHTASPTDPTNGP", "length": 150 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0S6H4-1", "protein_name": "Proteolipid protein 2", "gene_name": "plp2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAETEGSPFGGCLEKLMSYARTRKGTILAAEILLSFIILICYAASMYGGYTAVAICEMVFAIIFFVVYMLELDKQFLVVNWLWSDLFRAVIGAALYIITSLICVIGGTGDGARIAGGVFGLLAGILFAYDSYTLYLDIKSSRQHAAAPTDDRV", "length": 153 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RW43-1", "protein_name": "Proteolipid protein 2", "gene_name": "PLP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADSERLSAPGCWAACTNFSRTRKGFVLLAEIVVCLVILICFSAATSGFSFLSVIEMIFAAVFFVIYMCDLHTKIQIINWPWSDFFRTLIAAILYLITSILVLVEGGHSSKIAAGVLGLLAACLFGYDAYITFPLRQQRHTAAPTDPADGPV", "length": 152 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HNB8-1", "protein_name": "Proteolipid protein 2", "gene_name": "Plp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADSERLSAPGCWLACTGFLRTKKGLFLCAEIILCLVVLICFSASTSAYSSLSVIEMIFAAVLFVFYMCDLHSKISFINWPWTDFFRAFIAAILYLITSIVVLVDGKGSFKIAAGVLGIFATLLFGCDAYFTFPLKQQRHTAAPTDPTDGP", "length": 151 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q04941-1", "protein_name": "Proteolipid protein 2", "gene_name": "PLP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV", "length": 152 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R1Q7-1", "protein_name": "Proteolipid protein 2", "gene_name": "Plp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSERLSAPGCWLACTSFSRTKKGILLFAEIILCLVILICFSASTTSAYSSLSVIEMICAAVLLVFYTCDLHSKISFINWPWTDFFRSLIATILYLITSIVVLVEGRGSSRVVAGILGLLATLLFGYDAYITFPLKQQRHTAAPTDPTDGP", "length": 152 }, "evidence": [ { "id": "Q6Y1E2", "url": "https://omabrowser.org/oma/group/Q6Y1E2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6Y1E2", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6Y1E2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6Y1E2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6Y1E2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q6Y1E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Y1E2" }, { "id": "PRU00581", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00581" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MARVEL", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 137, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": "Asn108" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 108 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q7PCK7-1", "uniprot_ac": "Q7PCK7", "uniprot_id": "XRRA1_BOVIN", "mass": { "chemical_mass": 62037.0, "monoisotopic_mass": 62037.0 }, "refseq": {}, "gene_names": [ { "name": "XRRA1", "type": "recommended", "evidence": [ { "id": "Q7PCK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ] } ], "protein_names": [ { "name": "X-ray radiation resistance-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q7PCK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in the response of cells to X-ray radiation.", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7#function" }, { "database": "UniProtKB", "id": "Q6P2D8", "url": "https://www.uniprot.org/uniprotkb/Q6P2D8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XRRA1", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7", "locus": { "chromosome": "15", "start_pos": 54150612, "end_pos": 54223182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006610", "url": "https://www.ensembl.org/id/ENSBTAG00000006610" } ] } } ], "crossref": [ { "id": "Q7PCK7", "url": "https://alphafold.ebi.ac.uk/entry/Q7PCK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:369019", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:369019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q7PCK7", "url": "https://www.orthodb.org/?gene=Q7PCK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22710:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22710:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7PCK7-1", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LLTGNGLTSLPPSLAVAEQEASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERVGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTTEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDRPCSTCVKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRSVFGTTAPPQARPALSGSQPKLGRFLEFMDEFYQEPTASDLKG", "length": 549, "header": "sp|Q7PCK7-1|XRRA1_BOVIN Isoform 1 of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=2 SV=2 CANONICAL=Q7PCK7-1" }, "isoforms": [ { "isoform_ac": "Q7PCK7-1", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7/entry#Q7PCK7-1", "sequence": { "sequence": "LLTGNGLTSLPPSLAVAEQEASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERVGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTTEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDRPCSTCVKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRSVFGTTAPPQARPALSGSQPKLGRFLEFMDEFYQEPTASDLKG", "length": 549, "header": "sp|Q7PCK7-1|XRRA1_BOVIN Isoform 1 of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=2 SV=2 CANONICAL=Q7PCK7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle.", "journal": "Genome Res.", "date": "2001", "authors": "Smith T P, Grosse W M, Freking B A, Roberts A J, Stone R T, Casas E, Wray J E, White J, Cho J, Fahrenkrug S C, Bennett G L, Heaton M P, Laegreid W W, Rohrer G A, Chitko-McKown C G, Pertea G, Holt I, Karamycheva S, Liang F, Quackenbush J, Keele J W", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "reference": [ { "type": "PubMed", "id": "11282978", "url": "https://glygen.org/publication/PubMed/11282978" } ] }, { "title": "Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis.", "journal": "BMC Genomics", "date": "2003", "authors": "Mesak FM, Osada N, Hashimoto K, Liu QY, Ng CE", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "reference": [ { "type": "PubMed", "id": "12908878", "url": "https://glygen.org/publication/PubMed/12908878" } ] } ], "pathway": [ { "id": "bta:369019", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:369019", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to X-ray", "id": "GO:0010165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010165", "evidence": [ { "database": "UniProtKB", "id": "Q7PCK7", "url": "https://www.uniprot.org/uniprotkb/Q7PCK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7PCK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 549, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7PCK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7PCK7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 459, "end_pos": 461 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q7YQI4-1", "uniprot_ac": "Q7YQI4", "uniprot_id": "T176A_BOVIN", "mass": { "chemical_mass": 26500.0, "monoisotopic_mass": 26500.0 }, "refseq": { "ac": "NP_991348", "name": "transmembrane protein 176A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" }, "gene_names": [ { "name": "TMEM176A", "type": "recommended", "evidence": [ { "id": "Q7YQI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ] }, { "name": "CL1", "type": "synonym", "evidence": [ { "id": "NP_991348", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" }, { "id": "Q7YQI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ] }, { "name": "TMEM176A", "type": "synonym", "evidence": [ { "id": "NP_991348", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" } ] } ], "protein_names": [ { "name": "Transmembrane protein 176A", "type": "recommended", "evidence": [ { "id": "Q7YQI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4/entry#names_and_taxonomy" } ] }, { "name": "Corpus luteum protein 1", "type": "synonym", "evidence": [ { "id": "Q7YQI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4/entry#names_and_taxonomy" } ] }, { "name": "corpus luteum 1", "type": "synonym", "evidence": [ { "id": "NP_991348", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" } ] }, { "name": "corpus luteum protein 1", "type": "synonym", "evidence": [ { "id": "NP_991348", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" } ] }, { "name": "transmembrane protein 176A", "type": "synonym", "evidence": [ { "id": "NP_991348", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YQI4", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM176A", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4", "locus": { "chromosome": "4", "start_pos": 113413254, "end_pos": 113408423, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012078", "url": "https://www.ensembl.org/id/ENSBTAG00000012078" } ] } } ], "crossref": [ { "id": "Q7YQI4", "url": "https://alphafold.ebi.ac.uk/entry/Q7YQI4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404082", "url": "https://www.ncbi.nlm.nih.gov/gene/404082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404082", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQGGICW", "url": "https://omabrowser.org/oma/group/KQGGICW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DII1", "url": "https://www.orthodb.org/?gene=A0A452DII1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N3Q5", "url": "https://www.orthodb.org/?gene=F1N3Q5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q7YQI4", "url": "https://www.orthodb.org/?gene=Q7YQI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15756", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15756", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15756:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15756:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_991348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991348", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DII1", "url": "https://www.uniprot.org/uniprotkb/A0A452DII1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DII1-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DII1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Q5", "url": "https://www.uniprot.org/uniprotkb/F1N3Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Q5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YQI4", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YQI4-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METVDCGEAAPRAPQPASIQVHFHHESGLAKLLLGGCSLLQPLLLPRPRATSRALGRHRLLATSWVMQIVLGLLSGVLGGFLYIFSSTTLRNSGAPIWTGAVAVLAGAVAFIYEKRGGIYWALLRTLLALAAFSTATAATIIGAGRFYEYHFIFYKGICNVSPSWRPTGAPTLSPDLERLQQCTAYVNMLKALFISINAMLLGVWVLLLLASLLPLCLCCWRRYRRKEKRDLPLEETVRSE", "length": 241, "header": "sp|Q7YQI4-1|T176A_BOVIN Isoform 1 of Transmembrane protein 176A OS=Bos taurus OX=9913 GN=TMEM176A PE=2 SV=1 CANONICAL=Q7YQI4-1" }, "isoforms": [ { "isoform_ac": "A0A452DII1-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4/entry#A0A452DII1-1", "sequence": { "sequence": "METVDCGEAAPRAPQPASIQVHFHHESGLAKLLLGGCSLLQPLLLPRPRATSRALGRHRLLATSWVMQIVLGLLSGVLGGFLYIFSSTTLRNSGAPIWTGAVAVLAGAVAFIYEKRGGIYWALLRTLLALAAFSTATAATIIGAGRFYEYHFIFYKGICNVSPSWRPTGAPTLSPDLERLQQCTAYVNMLKALFISINAMLLGVWVLLLLASLLPLCLCCWRRYRRKETVRQEQEWRVGGLGRRKGSLQRVSTGMIPVLLPPWWPSPGSSYP", "length": 272, "header": "tr|A0A452DII1-1|A0A452DII1_BOVIN Computationally mapped isoform of Transmembrane protein 176A OS=Bos taurus OX=9913 GN=TMEM176A PE=3 SV=1 CANONICAL=Q7YQI4-1" }, "locus": { "chromosome": "4", "start_pos": 113412793, "end_pos": 113409643, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016021.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016021.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016021.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016021.6" } ] } }, { "isoform_ac": "F1N3Q5-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4/entry#F1N3Q5-1", "sequence": { "sequence": "SESPCPGGDRRQNGLLGFPRAGQLFSLPGHPPGPCALPDARAQLSPAAGKPWRGPVLQLGSCLILPCWHSTKYLPLLPARVSPALPTTLHCRSLRRAGKVGVQRHGDSGLRGGSPQGSPARQHPGALPPRVRSGQAPARRVLPAAAPPPAQAPRHLPGPGPPPAAGNLLGDADRVGAAERGPGRIPLHLLLYHPAELGSSHLDRGCDHRPRACVECCGEGPARRLRESWRKKEAGSWGGGRGCGSWGFCTNPAASTSPQAVLAGAVAFIYEKRGGIYWALLRTLLALAAFSTATAATIIGAGRFYEYHFIFYKGICNVSPSWRPTGAPTLSPDLERLQQCTAYVNMLKALFISINAMLLGVWVLLLLASLLPLCLCCWRRYRRKEKRDLPLEETVRSE", "length": 398, "header": "tr|F1N3Q5-1|F1N3Q5_BOVIN Computationally mapped isoform of Transmembrane protein 176A OS=Bos taurus OX=9913 GN=TMEM176A PE=3 SV=3 CANONICAL=Q7YQI4-1" }, "locus": { "chromosome": "4", "start_pos": 113413018, "end_pos": 113408565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052750.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052750.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052604.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052604.3" } ] } }, { "isoform_ac": "Q7YQI4-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4/entry#Q7YQI4-1", "sequence": { "sequence": "METVDCGEAAPRAPQPASIQVHFHHESGLAKLLLGGCSLLQPLLLPRPRATSRALGRHRLLATSWVMQIVLGLLSGVLGGFLYIFSSTTLRNSGAPIWTGAVAVLAGAVAFIYEKRGGIYWALLRTLLALAAFSTATAATIIGAGRFYEYHFIFYKGICNVSPSWRPTGAPTLSPDLERLQQCTAYVNMLKALFISINAMLLGVWVLLLLASLLPLCLCCWRRYRRKEKRDLPLEETVRSE", "length": 241, "header": "sp|Q7YQI4-1|T176A_BOVIN Isoform 1 of Transmembrane protein 176A OS=Bos taurus OX=9913 GN=TMEM176A PE=2 SV=1 CANONICAL=Q7YQI4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q7YQI4", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ], "site_lbl": "Ser38" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404082", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404082", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LE74-1", "protein_name": "Transmembrane protein 176A isoform X1", "gene_name": "Tmem176a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMETAHVGEVALRAPQPTHIDVHIHQESALAQLLLAGCSALRLPESASTRSLGSSRLLVASWVVQIVLGLLSVVLGGMLYICHYLAMNTSGAPFWTGIVAMMAGSVAFLHKKRGGTCWALLRTLLVLMNFCMSVAAIVLGACEFNVYRYYLRDDVCVSYSSNHWPTKPPNTPGPEEADRIGLCIFYTSMLKTLLISLQAMLLGVWVLLLLASLTPVCVYFWKRCFTKMKTDEKKLLGANVI", "length": 241 }, "evidence": [ { "id": "Q7YQI4", "url": "https://omabrowser.org/oma/group/Q7YQI4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4G068-1", "protein_name": "Transmembrane protein 176A", "gene_name": "Tmem176a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTDMGTADVGEVDPEAPQPTNIEVHIHQESVLAKLLLAGCSFLRVPASASTQSQGSSRVLVASWVVQIVLGILSVVLGGILYICHYLAMNTQGAPFWTGIVAMLAGAVAFLQKKRGGTCWALMRILLVLASFCTAVAAIVIGSREFNNYWYYLRDDVCKSDTSYRWSTMPSITPVPEEANRIGLCKYYTSMLKTLLISLQAMLLGVWVLLLLASLIPVCVYLWKRFFTKAETEKKLLGAAVI", "length": 243 }, "evidence": [ { "id": "Q7YQI4", "url": "https://omabrowser.org/oma/group/Q7YQI4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96HP8-1", "protein_name": "Transmembrane protein 176A", "gene_name": "TMEM176A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTADSDEMAPEAPQHTHIDVHIHQESALAKLLLTCCSALRPRATQARGSSRLLVASWVMQIVLGILSAVLGGFFYIRDYTLLVTSGAAIWTGAVAVLAGAAAFIYEKRGGTYWALLRTLLTLAAFSTAIAALKLWNEDFRYGYSYYNSACRISSSSDWNTPAPTQSPEEVRRLHLCTSFMDMLKALFRTLQAMLLGVWILLLLASLTPLWLYCWRMFPTKGKRDQKEMLEVSGI", "length": 235 }, "evidence": [ { "id": "Q7YQI4", "url": "https://omabrowser.org/oma/group/Q7YQI4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCS1-1", "protein_name": "Transmembrane protein 176A", "gene_name": "Tmem176a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTDMETAVVGKVDPEAPQPTHIDVHIHQESALAKLLLAGCSLLRIPASASTQSQGSSRVLVASWVVQTVLGALSVVLGGTLYIGHYLAMYSEGAPFWTGIVAMLAGAVAFLHKKRGGTCWALMRTLLVLASFCTAVAAIVIGSRELNFYWYFLGDDVCQRDSSYGWSTMPRTTPVPEEADRIALCIYYTSMLKTLLMSLQAMLLGIWVLLLLASLTPVCVYIWKRFFTKAETEEKKLLGAAVI", "length": 244 }, "evidence": [ { "id": "Q7YQI4", "url": "https://omabrowser.org/oma/group/Q7YQI4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q7YQI4", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of dendritic cell differentiation", "id": "GO:2001199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001199", "evidence": [ { "database": "UniProtKB", "id": "Q7YQI4", "url": "https://www.uniprot.org/uniprotkb/Q7YQI4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7YQI4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7YQI4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7YQI4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 38 ], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q7YQJ3-1", "uniprot_ac": "Q7YQJ3", "uniprot_id": "IPKG_BOVIN", "mass": { "chemical_mass": 7904.0, "monoisotopic_mass": 7904.0 }, "refseq": { "ac": "NP_991381", "name": "cAMP-dependent protein kinase inhibitor gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381" }, "gene_names": [ { "name": "PKIG", "type": "recommended", "evidence": [ { "id": "Q7YQJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3" } ] }, { "name": "PKIG", "type": "synonym", "evidence": [ { "id": "NP_991381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381" } ] } ], "protein_names": [ { "name": "cAMP-dependent protein kinase inhibitor gamma", "type": "recommended", "evidence": [ { "id": "Q7YQJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3/entry#names_and_taxonomy" } ] }, { "name": "PKI-gamma", "type": "synonym", "evidence": [ { "id": "NP_991381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381" }, { "id": "Q7YQJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3/entry#names_and_taxonomy" } ] }, { "name": "cAMP-dependent protein kinase inhibitor gamma", "type": "synonym", "evidence": [ { "id": "NP_991381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381" } ] }, { "name": "protein kinase (cAMP-dependent, catalytic) inhibitor gamma", "type": "synonym", "evidence": [ { "id": "NP_991381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381" } ] } ], "function": [ { "annotation": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.", "evidence": [ { "database": "UniProtKB", "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PKIG", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3", "locus": { "chromosome": "13", "start_pos": 73028130, "end_pos": 72947924, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005275", "url": "https://www.ensembl.org/id/ENSBTAG00000005275" } ] } } ], "crossref": [ { "id": "Q7YQJ3", "url": "https://alphafold.ebi.ac.uk/entry/Q7YQJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "404169", "url": "https://www.ncbi.nlm.nih.gov/gene/404169", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404169", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404169", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q7YQJ3", "url": "https://www.orthodb.org/?gene=Q7YQJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02827", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02827", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_991381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991381", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YQJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEVESSYSDFISCDRSGRRNAVPDIQGDSEAVSVRKLAGDMGELALEGAEGQAEVGTSDKEASSQPESSDGTTSS", "length": 76, "header": "sp|Q7YQJ3-1|IPKG_BOVIN Isoform 1 of cAMP-dependent protein kinase inhibitor gamma OS=Bos taurus OX=9913 GN=PKIG PE=3 SV=1 CANONICAL=Q7YQJ3-1" }, "isoforms": [ { "isoform_ac": "Q7YQJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3/entry#Q7YQJ3-1", "sequence": { "sequence": "MMEVESSYSDFISCDRSGRRNAVPDIQGDSEAVSVRKLAGDMGELALEGAEGQAEVGTSDKEASSQPESSDGTTSS", "length": 76, "header": "sp|Q7YQJ3-1|IPKG_BOVIN Isoform 1 of cAMP-dependent protein kinase inhibitor gamma OS=Bos taurus OX=9913 GN=PKIG PE=3 SV=1 CANONICAL=Q7YQJ3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404169", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404169", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cAMP-dependent protein kinase inhibitor activity", "id": "GO:0004862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004862", "evidence": [ { "database": "UniProtKB", "id": "Q7YQJ3", "url": "https://www.uniprot.org/uniprotkb/Q7YQJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7YQJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 76, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7YQJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7YQJ3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q7YRD0-1", "uniprot_ac": "Q7YRD0", "uniprot_id": "PNO1_BOVIN", "mass": { "chemical_mass": 27937.0, "monoisotopic_mass": 27937.0 }, "refseq": { "ac": "NP_898908", "name": "RNA-binding protein PNO1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898908" }, "gene_names": [ { "name": "PNO1", "type": "recommended", "evidence": [ { "id": "Q7YRD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ] }, { "name": "PNO1", "type": "synonym", "evidence": [ { "id": "NP_898908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898908" } ] } ], "protein_names": [ { "name": "RNA-binding protein PNO1", "type": "recommended", "evidence": [ { "id": "Q7YRD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein PNO1", "type": "synonym", "evidence": [ { "id": "NP_898908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898908" } ] }, { "name": "putatative 28 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_898908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898908" } ] } ], "function": [ { "annotation": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0#function" }, { "database": "UniProtKB", "id": "Q9NRX1", "url": "https://www.uniprot.org/uniprotkb/Q9NRX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNO1", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0", "locus": { "chromosome": "11", "start_pos": 66598955, "end_pos": 66589551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010604", "url": "https://www.ensembl.org/id/ENSBTAG00000010604" } ] } } ], "crossref": [ { "id": "Q7YRD0", "url": "https://alphafold.ebi.ac.uk/entry/Q7YRD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010604", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010604", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22392", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22392", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "360193", "url": "https://www.ncbi.nlm.nih.gov/gene/360193", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:360193", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360193", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPLRNNW", "url": "https://omabrowser.org/oma/group/TPLRNNW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q7YRD0", "url": "https://www.orthodb.org/?gene=Q7YRD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12826", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12826", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12826:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12826:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22891", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22891", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_898908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YRD0-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESVMEAQSPLAEDGFSQVTRKGGRRAKKRQAEQPSTQEEGGDATCMDTEEARPAKRPVFPPLSGDGFLSGKEETRKIPVPANRYTPLKENWLKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRAADRF", "length": 252, "header": "sp|Q7YRD0-1|PNO1_BOVIN Isoform 1 of RNA-binding protein PNO1 OS=Bos taurus OX=9913 GN=PNO1 PE=2 SV=1 CANONICAL=Q7YRD0-1" }, "isoforms": [ { "isoform_ac": "Q7YRD0-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0/entry#Q7YRD0-1", "sequence": { "sequence": "MESVMEAQSPLAEDGFSQVTRKGGRRAKKRQAEQPSTQEEGGDATCMDTEEARPAKRPVFPPLSGDGFLSGKEETRKIPVPANRYTPLKENWLKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRAADRF", "length": 252, "header": "sp|Q7YRD0-1|PNO1_BOVIN Isoform 1 of RNA-binding protein PNO1 OS=Bos taurus OX=9913 GN=PNO1 PE=2 SV=1 CANONICAL=Q7YRD0-1" }, "locus": { "chromosome": "11", "start_pos": 66598467, "end_pos": 66589592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014019.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014019.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014019.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014019.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning and characterization of a novel human RNA binding protein gene PNO1.", "journal": "DNA Seq.", "date": "2004", "authors": "Zhou Guang-Jin, Zhang Yue, Wang Jian, Guo Jin-Hu, Ni Jun, Zhong Zhao-Ming, Wang Li-Qun, Dang Yong-Jun, Dai Jian-Feng, Yu Long", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "reference": [ { "type": "PubMed", "id": "15497447", "url": "https://glygen.org/publication/PubMed/15497447" } ] } ], "pathway": [ { "id": "bta:360193", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360193", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6J3-1", "protein_name": "RNA-binding protein PNO1", "gene_name": "PNO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METQMEAQSPLAEDGFTQVTRKGSRRAKKRQAEQLSATEEGGGASHMDTEEARPAKRPIFPPLSGDGFLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALVRLDDLFLETFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRAADRF", "length": 252 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54K66-1", "protein_name": "RNA-binding protein pno1", "gene_name": "pno1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTEVIETKEVENIISEQSLKTESVKVSNKRSRDDEEMKDSEGGVKKTSFPQISVEDTEEEQIRKVTIPFNRIAPLKANWQQIYEPIVTHLKLQIRMNTKTRKVELKTSKSTKETSALQKAADFVHAFSLGFEVNDAVAILRLDDLYIDSFDVEDVKILKGDNLSRAIGRVAGKDGKTKFTIENVTKTRIVLADKRIHILGSYSNIRVAKDAICDLIIGSPPGKVYAKLRTVSSRIAERF", "length": 239 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5F414-1", "protein_name": "RNA-binding protein PNO1", "gene_name": "PNO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "METEAADESGFTSVASKRGRRKRRAAGAEPMEAAESAEAAGPQPSKRPAFPPLPAAALGVGKGEVRKVPVPANRYTPLKENWMKIFTPIVEHLQLQIRFNLKTRNVEIKTCSETKDLSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEVTDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADSKIHILGSFQNIKMARTAICNLILGSPPSKVYGNIRAVASRAAERF", "length": 242 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6VBQ8-1", "protein_name": "RNA-binding protein PNO1", "gene_name": "Pno1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METQNTGTEDGFTPVTHRGGRRAKKRQAEQSSAAGQDGDAGRMDTEEARPAKRPVFPPLSGDQLLTGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKDTKDVSALTKAADFVKAFVLGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF", "length": 248 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99216-1", "protein_name": "Pre-rRNA-processing protein PNO1", "gene_name": "PNO1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVAPTALKKATVTPVSGQDGGSSRIIGINNTESIDEDDDDDVLLDDSDNNTAKEEVEGEEGSRKTHESKTVVVDDQGKPRFTSASKTQGNKIKFESRKIMVPPHRMTPLRNSWTKIYPPLVEHLKLQVRMNLKTKSVELRTNPKFTTDPGALQKGADFIKAFTLGFDLDDSIALLRLDDLYIETFEVKDVKTLTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMARESVVSLILGSPPGKVYGNLRTVASRLKERY", "length": 274 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CPS7-1", "protein_name": "RNA-binding protein PNO1", "gene_name": "Pno1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METQSTGTEDGFTPVTHRGGRRAKKRQAEQSSAAGQDGEAGRMDTEEARPAKRPVFPPLSGDQLLTGKEETRKIPVPGNRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKDTKDVSALTKAADFVKAFVLGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVHVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF", "length": 248 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LTU6-1", "protein_name": "RNA-binding KH domain-containing protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAESTQMEVETATEGTVPLPPKPTFKPLKAHEMSDGKVQFRKIAVPPNRYSPLKKAWLDIYTPIYDQMKVDIRMNLKARKVELKTRADTPDISNLQKSADFVHAFMLGFDIPDAISLLRMDELYVESFEIKDVKTLKGEHLSRAIGRLSGKGGKTKFAIENSTKTRIVIADTRIHILGAFSNIKVARSSLCSLIMGSPAGKVYSKLRSVSARLNE", "length": 215 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NRX1-1", "protein_name": "RNA-binding protein PNO1", "gene_name": "PNO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESEMETQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDAGRMDTEEARPAKRPVFPPLCGDGLLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF", "length": 252 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VR89-1", "protein_name": "RNA-binding protein pno1", "gene_name": "l(1)G0004", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEAENIRADAFEPAKRATKRGASGGGQQDVEMQVDEATGIEGQVLGSSRASAPPKAKRARSELRKVSVPPHRYSSLKEHWMKIFTPVVEHMKLQIRFNMKARQVELRVGPETPDIANLQRGADFVRAFLCGFEVDDALALLRLEDLFVESFEIKDVKTLRGDHQSRAIGRLAGKGGRTKFTIENVTKTRIVLADSKIHILGSYQNIQLARRAVCNLILGSPPSKVYGNLRAVASRLSERM", "length": 240 }, "evidence": [ { "id": "Q7YRD0", "url": "https://omabrowser.org/oma/group/Q7YRD0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q7YRD0", "url": "https://www.uniprot.org/uniprotkb/Q7YRD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7YRD0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 252, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7YRD0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7YRD0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q85BD6-1", "uniprot_ac": "Q85BD6", "uniprot_id": "Q85BD6_BOVIN", "mass": { "chemical_mass": 68256.0, "monoisotopic_mass": 68256.0 }, "refseq": { "ac": "YP_209215", "name": "NADH dehydrogenase subunit 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209215" }, "gene_names": [ { "name": "ND5", "type": "recommended", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] }, { "name": "ND5", "type": "synonym", "evidence": [ { "id": "YP_209215", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209215" } ] } ], "protein_names": [ { "name": "NADH-ubiquinone oxidoreductase chain 5", "type": "recommended", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6/entry#names_and_taxonomy" } ] }, { "name": "7.1.1.2", "type": "synonym", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase subunit 5", "type": "synonym", "evidence": [ { "id": "YP_209215", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209215" } ] } ], "function": [ { "annotation": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6#function" }, { "database": "UniProtKB", "id": "ARBA00024313", "url": "https://www.uniprot.org/uniprotkb/ARBA00024313#function" }, { "database": "UniProtKB", "id": "RU003404", "url": "https://www.uniprot.org/uniprotkb/RU003404#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ND5", "url": "https://www.uniprot.org/uniprotkb/Q85BD6", "locus": { "chromosome": "MT", "start_pos": 13929, "end_pos": 12109, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043563", "url": "https://www.ensembl.org/id/ENSBTAG00000043563" } ] } } ], "crossref": [ { "id": "ENSBTAG00000043563", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043563", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3283887", "url": "https://www.ncbi.nlm.nih.gov/gene/3283887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:3283887", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283887", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GVGIMSF", "url": "https://omabrowser.org/oma/group/GVGIMSF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q85BD6", "url": "https://www.orthodb.org/?gene=Q85BD6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42829:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42829:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "YP_209215", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209215", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q85BD6-1", "url": "https://www.uniprot.org/uniprotkb/Q85BD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNMFSSLSLVTLLLLTTPIMMMSFNTYKPSNYPLYVKTAISYAFITSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFIPVALFVTWSIMEFSMWYMYSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKYIQSITLCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAANTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVNINENNPLLINSIKRLLIGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPSNAFKFSTLLGYFPTIMHRLAPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTLVTNQKGLIKLYFLSFLITILISMILFNFHE", "length": 606, "header": "tr|Q85BD6-1|Q85BD6_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 5 OS=Bos taurus OX=9913 GN=ND5 PE=3 SV=1 CANONICAL=Q85BD6-1" }, "isoforms": [ { "isoform_ac": "Q85BD6-1", "url": "https://www.uniprot.org/uniprotkb/Q85BD6/entry#Q85BD6-1", "sequence": { "sequence": "MNMFSSLSLVTLLLLTTPIMMMSFNTYKPSNYPLYVKTAISYAFITSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFIPVALFVTWSIMEFSMWYMYSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKYIQSITLCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAANTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVNINENNPLLINSIKRLLIGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPSNAFKFSTLLGYFPTIMHRLAPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTLVTNQKGLIKLYFLSFLITILISMILFNFHE", "length": 606, "header": "tr|Q85BD6-1|Q85BD6_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 5 OS=Bos taurus OX=9913 GN=ND5 PE=3 SV=1 CANONICAL=Q85BD6-1" }, "locus": { "chromosome": "Mitochondrion", "start_pos": 13926, "end_pos": 12109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060577.1", "url": "https://www.ensembl.org/id/ENSBTAT00000060577.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053152.1", "url": "https://www.ensembl.org/id/ENSBTAP00000053152.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 241, "start_aa": "Thr", "end_pos": 241, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr241", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:3283887", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283887", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P03915-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "MT-ND5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT", "length": 603 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P03921-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "Mtnd5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNIFTTSILLIFILLLSPILISMSNLIKHINFPLYTTTSIKFSFIISLLPLLMFFHNNMEYMITTWHWVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQFSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHPLTTNNNFILTTMLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAFFKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINENDPDLMNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLTMKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKSTSTLHTNMTTLTTNQKGLIKLYFMSFLINIILIIILYSINLE", "length": 607 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11661-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "Mt-nd5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNMMTSSILMILILLTTPIIISMTNLPKLIDFPSYATSSIKFSFLLSLLPLLLFFHHNTEYMITNWHWLTINSIKLTMSFKIDYFSILFLSVALFVTWSIMQFSSWYMHSDPHINRFIKYLMMFLITMLILTSANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRVGDIGFILAMTWFCLNMNSWELQQIFLTNTNNLVPLTGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFHPLTSNNSTIMTAMLCLGAITTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTLGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGNMMKAMPFTSSCLIIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALMITLIATSMTAVYSMRIIYFVTMTKPRYSPLITINENNPNLINPIKRLALGSILAGFLISLNIPPTNIQILTMPWHLKMTALLITILGFAIALELNNLTLNLSMSKPTKLSSFSTSLGYYPPIMHRIIPQKTLNSSYKLSLNLLDLIWLEKTIPKSTSITQTQLSKMMSNQKGLIKLYFLSFLITISLIFILHTLNPEWFQ", "length": 609 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q85A52-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "ND5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "METPLLLNTLTTLTLLTLLTPIILPPLLNLKNSPMSITKTIKTAFLISLIPTTIFIHSGAESIATHWEWQFIPNFKIPISLKMDMYSMMFFPIALFVTWSILEFATWYMASEPFITKFFTYLLTFLIAMLTLTIANNMFLLFVGWEGVGIMSFLLIGWWQGRAEANTAALQAMIYNRIGDIGLILSMAWLASSLNTWEIQQITHPNQTPTLPLLGLILAATGKSAQFGLHPWLPAAMEGPTPVSALLHSSTMVVAGIFLLIRTHPFLSSNKTALTTCLCLGALSTLFAATCALTQNDIKKIIAFSTSSQLGLMMVTIGLDLPQLAFLHISTHAFFKAMLFLCSGLIIHSLNGEQDIRKMGCLQKTLPMTTSCLTIGNLALMGTPFLAGFYSKDLIIENLNTSYINTWALSLTLLATSFTATYSLRMTLLVQTGHTRTPAITPINENTPPAILPIMRLALGSIMAGLLISSLILPPKTPPMTMPTITKTAAIIVTTLGIILALELSSLSYSLTPPKHNPLMNFSSSLGYFNPLTHRISPSILLHTGQKIASHLIDMAWYKKMGPEGLANLHLTMTKISTTLHTGLIKSYLGSFALTILTTILLIQK", "length": 605 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9MIY0-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "mt-nd5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTDMIMPLTLILIFAVLSYPLLKPKSYSKSNNSFQAWNAVHVSFLISLIPLTMMLYKESDHVVMCWSWMNTQAFNVDLSFKFDYYSVTFTSIALFITWSILEFASWYMASYPQKELFYKYLLLFLMSMIILVTANNLFQLFIGWEGVGIMSFLLIGWWFGRTEANTASLQAVIYNRMGDIGFILTLAWMAMYLNSWDIQQIFILSKDFDMTIPQIGLIIAATGKSAQFTLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRLHPIMETNKLAPTICLCLGALTTLFAATCALTQNDIKKIVAFSTSSQLGLMMVAIGLNQPHLAFFHICTHAFFKAMLFLCSGAIIHSLNNEQDIRKMGGTYHTLPMTTNYLTIGKMALMGTPFLAGFFSKDAILEAMTTSHLNAWALTLTLIATSFTAVYSFRMIYLVCLGSPRHKTYETIDENHIPTNTIQRLAWGSIIAGLIISYTMIPLKTPILTMPIYLKLAAILVTLLGIILGLEISTLANKINKNTTPGIPFHFSISLIFFPILHRLIPMRKLFMGESAATKIEKSWSELFGPCGIAFTLMTVATFVKDHRMASIKSYLAVFLTSIILKMMMLKLYT", "length": 606 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9TDR1-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "MT-ND5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPFASLTLTTLIILTIPIMMSNSNIYKTNLYPNYVKTTVSYAFTLSLVPLLMFMHTGQEMIISNWHWMTLQTVELSLSFKMDYFSVMFIPVALFVTWSIMEFSMWYMHSDPFINRFFKYLVLFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWHGRTDANTAALQAILYNRIGDIGFVLSMAWFLTHSNAWDLQQIFMLNNECPNMPLIGLLLAAAGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFYPLMETNKLVQTMTLCLGAITTLFTALCAITQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICMHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLYKAMPFTTTALIIGSLALTGMPYLTGFYSKDLIIEAVNMSYTNAWALLMTLIATSLTAAYSTRIIFFAFLGKPRFPPLVLINENNPLLINSIKRLLIGSIFAGFIISNNIPPMTVPNTTMPLYMKMTALIVTIMGFMLALELNNTTYYLKFKYPSQTYKFSNMLGYYPSIMHRLPTYHNLSMSQKSASSLLDLIWLETILPKTTSFIQMKMSIMVSNQKGLIKLYFLSFLITIMISMTLFNYHE", "length": 606 }, "evidence": [ { "id": "Q85BD6", "url": "https://omabrowser.org/oma/group/Q85BD6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" }, { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" }, { "name": "electron transport coupled proton transport", "id": "GO:0015990", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015990", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" }, { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "Q85BD6", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTH1-1", "Q85BD6-1", "A0AAA9SEY3-1", "A0AAA9TZL3-1", "P03920-1", "P03887-1", "P03892-1", "P03898-1", "P03902-1", "P03910-1", "P03924-1", "P04394-1", "P15690-1", "P17694-1", "P23709-1", "P25708-1", "P42026-1", "P42028-1", "Q6QTH0-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] }, { "id": "R-BTA-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "P25708-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-163217", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163217" } ] }, { "id": "R-BTA-5419271", "name": "55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03898-1", "P03910-1", "P03902-1", "P68530-1", "Q6QTH1-1", "Q85BD6-1", "Q3T116-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-5419271", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419271" } ] }, { "id": "R-BTA-6799179", "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799179" } ] }, { "id": "R-BTA-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799196", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799196" } ] }, { "id": "R-BTA-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799197", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799197" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MP25", "gene_name": "ACAD9", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] } ] }, { "uniprot_ac": "A0AAA9SEY3", "gene_name": "", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] } ] }, { "uniprot_ac": "A0AAA9TZL3", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] } ] }, { "uniprot_ac": "F1MJQ5", "gene_name": "NDUFAF7", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] } ] }, { "uniprot_ac": "P03887", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] } ] }, { "uniprot_ac": "P03892", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] } ] }, { "uniprot_ac": "P03898", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] } ] }, { "uniprot_ac": "P03902", "gene_name": "MT-ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] } ] }, { "uniprot_ac": "P03910", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] } ] }, { "uniprot_ac": "P03920", "gene_name": "MT-ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] } ] }, { "uniprot_ac": "P03924", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] } ] }, { "uniprot_ac": "P04394", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P17694", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] } ] }, { "uniprot_ac": "P23709", "gene_name": "NDUFS3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] } ] }, { "uniprot_ac": "P25708", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] } ] }, { "uniprot_ac": "P42026", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] } ] }, { "uniprot_ac": "P42028", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] } ] }, { "uniprot_ac": "P68530", "gene_name": "MT-CO2", "activity": [ { "ec_number": "7.1.1.9", "activity": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out).", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] }, { "ec_number": "7.1.1.9", "activity": "", "evidence": [ { "id": "P68530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68530" } ] } ] }, { "uniprot_ac": "Q3T116", "gene_name": "MRPL58", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] } ] }, { "uniprot_ac": "Q6QTH0", "gene_name": "ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] } ] }, { "uniprot_ac": "Q6QTH1", "gene_name": "ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] } ] }, { "uniprot_ac": "Q85BD6", "gene_name": "ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" }, { "id": "PF06455", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06455" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADH dehydrogenase subunit 5 C-terminal", "eco_id": "ECO_0000259", "start_pos": 422, "end_pos": 602, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" }, { "id": "PF00662", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00662" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 118, "start_aa": "Trp", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" }, { "id": "PF00361", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00361" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADH:quinone oxidoreductase/Mrp antiporter transmembrane", "eco_id": "ECO_0000259", "start_pos": 134, "end_pos": 418, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.1.1.2", "ec_name": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "7.1.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2" }, { "id": "7.1.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.1.1.2" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 241 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 400, "end_pos": 402 }, { "start_pos": 506, "end_pos": 508 }, { "start_pos": 541, "end_pos": 543 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q863D4-1", "uniprot_ac": "Q863D4", "uniprot_id": "KCNRG_BOVIN", "mass": { "chemical_mass": 30370.0, "monoisotopic_mass": 30370.0 }, "refseq": { "ac": "NP_991377", "name": "potassium channel regulatory protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377" }, "gene_names": [ { "name": "KCNRG", "type": "recommended", "evidence": [ { "id": "Q863D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ] }, { "name": "CLLD4", "type": "synonym", "evidence": [ { "id": "Q863D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ] }, { "name": "KCNRG", "type": "synonym", "evidence": [ { "id": "NP_991377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377" } ] } ], "protein_names": [ { "name": "Potassium channel regulatory protein", "type": "recommended", "evidence": [ { "id": "Q863D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863D4/entry#names_and_taxonomy" } ] }, { "name": "CLLD4-like protein", "type": "synonym", "evidence": [ { "id": "NP_991377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377" } ] }, { "name": "Potassium channel regulator", "type": "synonym", "evidence": [ { "id": "Q863D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863D4/entry#names_and_taxonomy" } ] }, { "name": "Protein CLLD4", "type": "synonym", "evidence": [ { "id": "Q863D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863D4/entry#names_and_taxonomy" } ] }, { "name": "potassium channel regulatory protein", "type": "synonym", "evidence": [ { "id": "NP_991377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377" } ] }, { "name": "putative potassium channel regulatory protein", "type": "synonym", "evidence": [ { "id": "NP_991377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377" } ] } ], "function": [ { "annotation": "Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4#function" }, { "database": "UniProtKB", "id": "Q8N5I3", "url": "https://www.uniprot.org/uniprotkb/Q8N5I3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNRG", "url": "https://www.uniprot.org/uniprotkb/Q863D4", "locus": { "chromosome": "12", "start_pos": 19468197, "end_pos": 19462731, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008176", "url": "https://www.ensembl.org/id/ENSBTAG00000008176" } ] } } ], "crossref": [ { "id": "Q863D4", "url": "https://alphafold.ebi.ac.uk/entry/Q863D4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404166", "url": "https://www.ncbi.nlm.nih.gov/gene/404166", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404166", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404166", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SYIMDFL", "url": "https://omabrowser.org/oma/group/SYIMDFL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q863D4", "url": "https://www.orthodb.org/?gene=Q863D4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_991377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q863D4-1", "url": "https://www.uniprot.org/uniprotkb/Q863D4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGQELVTLNVGGKVFTTRSSTLQQFPGSRLMRMLDGRDKEFKMVDGQIFVDRDGVLFSFILDFLRTQQLLLPTDFSDHLRLQREALFYELNPLVDLLNQEHKLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFIEQPSAPASSSNSFPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTRIRYISIKPDNRKLANGTNVLGLLIDTLLMEGFHLVGTRTVSSEDRTECYSFERIKKPDALAMNKTLKSETTLMPEQ", "length": 267, "header": "sp|Q863D4-1|KCNRG_BOVIN Isoform 1 of Potassium channel regulatory protein OS=Bos taurus OX=9913 GN=KCNRG PE=2 SV=1 CANONICAL=Q863D4-1" }, "isoforms": [ { "isoform_ac": "Q863D4-1", "url": "https://www.uniprot.org/uniprotkb/Q863D4/entry#Q863D4-1", "sequence": { "sequence": "MSGQELVTLNVGGKVFTTRSSTLQQFPGSRLMRMLDGRDKEFKMVDGQIFVDRDGVLFSFILDFLRTQQLLLPTDFSDHLRLQREALFYELNPLVDLLNQEHKLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFIEQPSAPASSSNSFPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTRIRYISIKPDNRKLANGTNVLGLLIDTLLMEGFHLVGTRTVSSEDRTECYSFERIKKPDALAMNKTLKSETTLMPEQ", "length": 267, "header": "sp|Q863D4-1|KCNRG_BOVIN Isoform 1 of Potassium channel regulatory protein OS=Bos taurus OX=9913 GN=KCNRG PE=2 SV=1 CANONICAL=Q863D4-1" }, "locus": { "chromosome": "12", "start_pos": 19467710, "end_pos": 19462770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010748.3", "url": "https://www.ensembl.org/id/ENSBTAT00000010748.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010748.2", "url": "https://www.ensembl.org/id/ENSBTAP00000010748.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404166", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404166", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RK26-1", "protein_name": "Potassium channel regulatory protein", "gene_name": "KCNRG", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSTQELVTLNVGGKIFTTRSSTIKQFPASRLTRMLDGRDQEFKMVGGQIFVDRDGVLFSFILDFLRTHQLLLPTDFSDYLRLQREVLFYELDPLVDLLNQEHLLQPKPALVEVHFLSRNTQAFFRVFSSCGKTIEMLTGRITVFVEQTLVAPTWSSNSFPPQMTLLPLPPQRPSYHDLVFHCGSDSSTDNQSGIRYVSIKPDNRKLANGTNVLGLLIDTLLMEDFHLVSTRTASSEDKTECYSFERIKRSEALTMNKTLKPGTILMPQQSEKKK", "length": 274 }, "evidence": [ { "id": "Q863D4", "url": "https://omabrowser.org/oma/group/Q863D4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2TUM3-1", "protein_name": "Potassium channel regulatory protein", "gene_name": "Kcnrg", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGQDLVTLNVGGRIFTTRPSTLKQFPASRLAGMLDGRDQEFKTVDGQIFVDRDGALFSFILDFLRNHELLLPSDFADHHRLQREALFYELDSLVDLLSQFLLQSRSAVMEVHFLNQNTQAFFRVFGSCSKTIEMLSGRITMFVERPTALTGNRNSPLALPPQRPSHHDLLFHCGSDGAAENQAGVRYISIKPDNRKLANGTNVLGLLVDTLLKEGFHLVSTRTPASGEKSECYVFERITTPQVLGMSKTPKSETTTMPAPSQK", "length": 264 }, "evidence": [ { "id": "Q863D4", "url": "https://omabrowser.org/oma/group/Q863D4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N5I3-1", "protein_name": "Potassium channel regulatory protein", "gene_name": "KCNRG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTLLKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK", "length": 272 }, "evidence": [ { "id": "Q863D4", "url": "https://omabrowser.org/oma/group/Q863D4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ], "pmid": "" }, { "name": "negative regulation of delayed rectifier potassium channel activity", "id": "GO:1902260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902260", "evidence": [ { "database": "UniProtKB", "id": "Q863D4", "url": "https://www.uniprot.org/uniprotkb/Q863D4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q863D4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 267, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q863D4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q863D4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 254, "end_pos": 256 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q865F8-1", "uniprot_ac": "Q865F8", "uniprot_id": "AHSP_BOVIN", "mass": { "chemical_mass": 10718.0, "monoisotopic_mass": 10718.0 }, "refseq": { "ac": "NP_803488", "name": "alpha-hemoglobin-stabilizing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488" }, "gene_names": [ { "name": "AHSP", "type": "recommended", "evidence": [ { "id": "Q865F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ] }, { "name": "AHSP", "type": "synonym", "evidence": [ { "id": "NP_803488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488" } ] }, { "name": "ERAF", "type": "synonym", "evidence": [ { "id": "NP_803488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488" }, { "id": "Q865F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ] } ], "protein_names": [ { "name": "Alpha-hemoglobin-stabilizing protein", "type": "recommended", "evidence": [ { "id": "Q865F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865F8/entry#names_and_taxonomy" } ] }, { "name": "Erythroid-associated factor", "type": "synonym", "evidence": [ { "id": "Q865F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865F8/entry#names_and_taxonomy" } ] }, { "name": "alpha-hemoglobin-stabilizing protein", "type": "synonym", "evidence": [ { "id": "NP_803488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488" } ] }, { "name": "erythroid-associated factor", "type": "synonym", "evidence": [ { "id": "NP_803488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488" } ] } ], "function": [ { "annotation": "Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AHSP", "url": "https://www.uniprot.org/uniprotkb/Q865F8", "locus": { "chromosome": "25", "start_pos": 27544133, "end_pos": 27537790, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006457", "url": "https://www.ensembl.org/id/ENSBTAG00000006457" } ] } } ], "crossref": [ { "id": "Q865F8", "url": "https://alphafold.ebi.ac.uk/entry/Q865F8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006457", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006457", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "338381", "url": "https://www.ncbi.nlm.nih.gov/gene/338381", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:338381", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338381", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DWIKFYL", "url": "https://omabrowser.org/oma/group/DWIKFYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q865F8", "url": "https://www.orthodb.org/?gene=Q865F8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15914", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15914", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15914:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15914:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_803488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q865F8-1", "url": "https://www.uniprot.org/uniprotkb/Q865F8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALIQTNKDLISKGIKEFNILLNQQVFSDPAISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKSS", "length": 92, "header": "sp|Q865F8-1|AHSP_BOVIN Isoform 1 of Alpha-hemoglobin-stabilizing protein OS=Bos taurus OX=9913 GN=AHSP PE=3 SV=1 CANONICAL=Q865F8-1" }, "isoforms": [ { "isoform_ac": "Q865F8-1", "url": "https://www.uniprot.org/uniprotkb/Q865F8/entry#Q865F8-1", "sequence": { "sequence": "MALIQTNKDLISKGIKEFNILLNQQVFSDPAISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKSS", "length": 92, "header": "sp|Q865F8-1|AHSP_BOVIN Isoform 1 of Alpha-hemoglobin-stabilizing protein OS=Bos taurus OX=9913 GN=AHSP PE=3 SV=1 CANONICAL=Q865F8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A novel erythroid-specific marker of transmissible spongiform encephalopathies.", "journal": "Nat. Med.", "date": "2001", "authors": "Miele G, Manson J, Clinton M", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "reference": [ { "type": "PubMed", "id": "11231637", "url": "https://glygen.org/publication/PubMed/11231637" } ] } ], "pathway": [ { "id": "bta:338381", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338381", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AK38-1", "protein_name": "Alpha-hemoglobin-stabilizing protein", "gene_name": "AHSP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALLPTNQDLISAGIKEFNILLNQQVFSEPAIPEEAMVTVVNDWMDLYLNYYKKKMVGEQEEQDKALQELRQELNTLSASFLDKYRNFLKSL", "length": 92 }, "evidence": [ { "id": "Q865F8", "url": "https://omabrowser.org/oma/group/Q865F8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9NZD4-1", "protein_name": "Alpha-hemoglobin-stabilizing protein", "gene_name": "AHSP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS", "length": 102 }, "evidence": [ { "id": "Q865F8", "url": "https://omabrowser.org/oma/group/Q865F8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hemoglobin binding", "id": "GO:0030492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030492", "evidence": [ { "database": "UniProtKB", "id": "Q865F8", "url": "https://www.uniprot.org/uniprotkb/Q865F8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q865F8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 92, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q865F8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q865F8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q866X7-1", "uniprot_ac": "Q866X7", "uniprot_id": "CAH11_BOVIN", "mass": { "chemical_mass": 36144.0, "monoisotopic_mass": 36144.0 }, "refseq": { "ac": "NP_783648", "name": "carbonic anhydrase-related protein 11 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" }, "gene_names": [ { "name": "CA11", "type": "recommended", "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ] }, { "name": "CA11", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] }, { "name": "CAR-XI", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] }, { "name": "CAR11", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] } ], "protein_names": [ { "name": "Carbonic anhydrase-related protein 11", "type": "recommended", "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7/entry#names_and_taxonomy" } ] }, { "name": "CA-RP XI", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" }, { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7/entry#names_and_taxonomy" } ] }, { "name": "CA-XI", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" }, { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7/entry#names_and_taxonomy" } ] }, { "name": "CARP XI", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" }, { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7/entry#names_and_taxonomy" } ] }, { "name": "carbonic anhydrase-related XI protein", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] }, { "name": "carbonic anhydrase-related protein 11 precursor", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] }, { "name": "carbonic anhydrase-related protein 11", "type": "synonym", "evidence": [ { "id": "NP_783648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648" } ] } ], "function": [ { "annotation": "Does not have a catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CA11", "url": "https://www.uniprot.org/uniprotkb/Q866X7", "locus": { "chromosome": "18", "start_pos": 55279515, "end_pos": 55285506, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006757", "url": "https://www.ensembl.org/id/ENSBTAG00000006757" } ] } } ], "crossref": [ { "id": "Q866X7", "url": "https://alphafold.ebi.ac.uk/entry/Q866X7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "326334", "url": "https://www.ncbi.nlm.nih.gov/gene/326334", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:326334", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:326334", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q866X7", "url": "https://www.orthodb.org/?gene=Q866X7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_783648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q866X7-1", "url": "https://www.uniprot.org/uniprotkb/Q866X7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCVVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNLSAATRGPNGLAILSLFVNVAGSSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNGRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGAPHGR", "length": 328, "header": "sp|Q866X7-1|CAH11_BOVIN Isoform 1 of Carbonic anhydrase-related protein 11 OS=Bos taurus OX=9913 GN=CA11 PE=2 SV=1 CANONICAL=Q866X7-1" }, "isoforms": [ { "isoform_ac": "Q866X7-1", "url": "https://www.uniprot.org/uniprotkb/Q866X7/entry#Q866X7-1", "sequence": { "sequence": "MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCVVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNLSAATRGPNGLAILSLFVNVAGSSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNGRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGAPHGR", "length": 328, "header": "sp|Q866X7-1|CAH11_BOVIN Isoform 1 of Carbonic anhydrase-related protein 11 OS=Bos taurus OX=9913 GN=CA11 PE=2 SV=1 CANONICAL=Q866X7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 118, "start_aa": "Asn", "end_pos": 118, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn118", "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 170, "start_aa": "Asn", "end_pos": 170, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn170", "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 260, "start_aa": "Asn", "end_pos": 260, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn260", "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:326334", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:326334", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ], "pmid": "" }, { "name": "hydro-lyase activity", "id": "GO:0016836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016836", "evidence": [ { "database": "UniProtKB", "id": "Q866X7", "url": "https://www.uniprot.org/uniprotkb/Q866X7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q866X7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 328, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q866X7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q866X7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q866X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866X7" }, { "id": "PRU01134", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01134" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-carbonic anhydrase", "eco_id": "ECO_0000255", "start_pos": 33, "end_pos": 303, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "Asn260,Asn170,Asn118" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 118, 170, 260 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 170, "end_pos": 172 }, { "start_pos": 260, "end_pos": 262 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q8HXA6-1", "uniprot_ac": "Q8HXA6", "uniprot_id": "ASB15_BOVIN", "mass": { "chemical_mass": 65851.0, "monoisotopic_mass": 65851.0 }, "refseq": { "ac": "NP_777112", "name": "ankyrin repeat and SOCS box protein 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777112" }, "gene_names": [ { "name": "ASB15", "type": "recommended", "evidence": [ { "id": "Q8HXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" } ] }, { "name": "ASB15", "type": "synonym", "evidence": [ { "id": "NP_777112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777112" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 15", "type": "recommended", "evidence": [ { "id": "Q8HXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6/entry#names_and_taxonomy" } ] }, { "name": "ASB-15", "type": "synonym", "evidence": [ { "id": "NP_777112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777112" }, { "id": "Q8HXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 15", "type": "synonym", "evidence": [ { "id": "NP_777112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777112" } ] } ], "function": [ { "annotation": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB15", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6", "locus": { "chromosome": "4", "start_pos": 87942478, "end_pos": 87910497, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002151", "url": "https://www.ensembl.org/id/ENSBTAG00000002151" } ] } } ], "crossref": [ { "id": "Q8HXA6", "url": "https://alphafold.ebi.ac.uk/entry/Q8HXA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282591", "url": "https://www.ncbi.nlm.nih.gov/gene/282591", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282591", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282591", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVNDTHF", "url": "https://omabrowser.org/oma/group/HVNDTHF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8HXA6", "url": "https://www.orthodb.org/?gene=Q8HXA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198:SF187", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198:SF187", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777112", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HXA6-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDANDDPDEDHLTSYDVQLSIQESIEAGKTVFYPERFVPLSDQNRKLVEAIQQGHILELQEYVKYKYALDEADEKGWFPLHEAVVQPIQQILEVVLDASYKTLWEFKTSDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLLAIKRGSYDMVSALLKHNTSLDQPCVKRWSAMHEAAKQGHKDIIALLLNNGGNVHLKDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNIPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSGLTPIHSAADGQNAQCLELLIENGFDVNSLLADHISESYDDERKTALYFAVCNNDILCTEILLAAGADPNLDPLNCLLVAVRANNHEIVRLLLAHGANVNCYFMHVNDTRFPSAIQYALNDEVMLRLLLNNGYQVEMCFECMHGDIFGNSFVWSEIEEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGSVIRVLIDYMDYIPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQRLCQPTLMEKLSLPPTIQRYILFKEYDLYGQELNLP", "length": 588, "header": "sp|Q8HXA6-1|ASB15_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 15 OS=Bos taurus OX=9913 GN=ASB15 PE=2 SV=2 CANONICAL=Q8HXA6-1" }, "isoforms": [ { "isoform_ac": "Q8HXA6-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6/entry#Q8HXA6-1", "sequence": { "sequence": "MDANDDPDEDHLTSYDVQLSIQESIEAGKTVFYPERFVPLSDQNRKLVEAIQQGHILELQEYVKYKYALDEADEKGWFPLHEAVVQPIQQILEVVLDASYKTLWEFKTSDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLLAIKRGSYDMVSALLKHNTSLDQPCVKRWSAMHEAAKQGHKDIIALLLNNGGNVHLKDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNIPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSGLTPIHSAADGQNAQCLELLIENGFDVNSLLADHISESYDDERKTALYFAVCNNDILCTEILLAAGADPNLDPLNCLLVAVRANNHEIVRLLLAHGANVNCYFMHVNDTRFPSAIQYALNDEVMLRLLLNNGYQVEMCFECMHGDIFGNSFVWSEIEEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGSVIRVLIDYMDYIPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQRLCQPTLMEKLSLPPTIQRYILFKEYDLYGQELNLP", "length": 588, "header": "sp|Q8HXA6-1|ASB15_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 15 OS=Bos taurus OX=9913 GN=ASB15 PE=2 SV=2 CANONICAL=Q8HXA6-1" }, "locus": { "chromosome": "4", "start_pos": 87941580, "end_pos": 87924326, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002787.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002787.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002787.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002787.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of a bovine gene encoding an ankyrin repeat and SOCS box protein (ASB15).", "journal": "Anim. Genet.", "date": "2003", "authors": "McDaneld T G, Moody D E", "evidence": [ { "database": "UniProtKB", "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" } ], "reference": [ { "type": "PubMed", "id": "12755830", "url": "https://glygen.org/publication/PubMed/12755830" } ] } ], "pathway": [ { "id": "bta:282591", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282591", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y786-1", "protein_name": "Ankyrin repeat and SOCS box containing 15", "gene_name": "Asb15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNTHVHDVDPQEPYAFSWLLEGGNNTYMDIHDDPNDEHLASYDIQLCIQESIEASQAVFHPERSVQLSDQNRKLVEAIRQGHIFELQEYVLHKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLWEFKTCDGETPLTLAIKAGLVENVKTLLEKGVWPNTKNDKGETPLLIAIKQGSYDIVSALIKYNTSLEQPCVKRWSAMHEAAKQGRKDIITLLLNHRGDVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIEKSGLTPIHSAADGQNAQCLELLIENGFDVNALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLNCLLVAVRANRHEIVRLLLSYGANVNCYFMHVNDTRFPSAIQYALNDEIMLRLLLNNGYQVELCFDCMHGDIFGNSFVWSEIEEEGLPGWTSCVIKDNPFCEFITVPWMKHLVGNIVRILIDYMDYVPLCAKLKSVLEVQREWPEIRQIIENPCSLKHLCRLKIRRAMGLQRLCQPASMEKLPLPAALQRYLLFKEYDLYGQ", "length": 611 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XCC7-1", "protein_name": "Ankyrin repeat and SOCS box containing 15", "gene_name": "ASB15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTDESEDVVEDLITEYAIQLSIQESNAAKPRMSSFSDSFVPPSEENRKIVTAIKEGQIFGLQDLVKWKYALDEADERGWFPLHEAAAQPIQQILEIILDASYKAMWEYKTSDGETPLTLAAKAGYVGNVRALLEKGVWPNTTNDKGETPLLIAVRSGSFEMASTLIKHNCRIHQPCVKRWSAMHEAAKQGRKDIVSLLLKNGGNVNLKDGYGVTPLGVAAEYGHCDVLEHLIHKGGDVQALADDGSSILFEAAGGGNPDCIALLLEYGGSGNVPNKAGLLPIHKAAYEGHYLVLKYLIPVTSQTAIQKSGISPVHSAADGQNSQCLELLIESDFDVNTILDDHISNSYDDERKTALYFAVSNNDILCTEILLKAGANPSKDPLNCLLVAVRGGNHEIVRLLLSYGANVNCYFMMVNDTHFPSAIQYALNDEVMLRLLLNHGYNVELCFDCMHQDTFGNSFVWSTPEEEILPGWTSSVIKDNPFCDFIAVPWLKHLAGKVVRIFIDYMDYVPLCTKIKFVLETQKEWTEIRQILDNPRPLKHLCRLKIRKLMGLWRLQKLSSMKKFPLPPVLKNYILYKEYDLYGKEIHLE", "length": 590 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7EYL5-1", "protein_name": "Ankyrin repeat and SOCS box protein 15 isoform X1", "gene_name": "Asb15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLESQSSKTQAFKGQVIKGFNRTSEPNKIEFSYRWIKILICLYVCTKERQILHFHFAFATLIIPIALNPLLRIRKPPLSTLFADMDIHDDPSEDHLTSHDIQLCIQESIEASQAVVHPERLVTLSDQNRKLVEAIRQGHIFELQECVQHKYALDEADEKGWFPLHEAVVQPIQQILETVLDASYKTVWEFKTCDGETPLTLAVKADLVGNVKTLLEKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCIKRWSAMHEAAKQGRKDIIALLLSHGGNVHLRDGFGVTPLGVAAEYGHFDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIRKSGLTPVHSAADGQNTQCLELLIDNGFDVNALLADHISQSYDDQRKTALYFAVSNNDIHCTEVLLAAGADPNLDPLNCLLVAVRANSHEIVRLLLSYGANVNCYFMHVNDTRFPSAIQYALNDEVMLRLLLNNGYQVELCFDCMHGDIFGNSFVWSEIEEEVLPGWTSCIIKDNPFCEFITVPWMKHLVGSIVRILIDYMDYVPLCAKLKSVLEVQREWPEIRQIIENPCSLRHLCRLKIRRLMGLQRLCQPASMEKLPLPAAIRRYLLFKEYDLYEQQLKLK", "length": 672 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AC58J8D3-1", "protein_name": "Ankyrin repeat and SOCS box protein 15b isoform X1", "gene_name": "asb15b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQCVFVVLAATREGTQNLLPSHDKVTHILQASGESRNTMDYMEQMDEDQLIEYAIQMSLQDACGYSVFSEPLSALETASDENLKILSAIDQGDTFALRKMHKCSEAYKERDSRGLLPMHRACVQPDSCVLDIVLLACYDLTMEETTSDGETPLTLACQSGHVENVKVLLQHGASPHNMNSKNETPLLLAVRKDSYDMVYALIMGGASVEQVCLRKWTATHEAAKVGCVDILMLLLRHGGKVMGRDGHGVTPLGIAAEYGHPQILTVLIQHGGDVSAQATNGDSVLYDAAGCGNLDCICLLLQHGANPNVASLAYQLPIHRAAYEGHYLALKTLIPITTKRAIRLSGMSPVHSAADGGQAQCLELLIEKGFDVNPILGCHISENYGDMRKTPLYFAVCNGDVTCTEMLLKAGAKPDLDPLRCLLVAVRAEKYELVRLLLAHGADVNCIFSVVSDTLFPTALQYCFKDEMMLRLLLNNGYHAESCFECYHDNSVKTYTWSEFHNQSYQNKSTPDKVTFCEFISVSWMAHLAGRVVQILLDYVSQAHICSKLQRIMERQEEWPDICDILRNPRSLKHQARLVIRRHMTLKRLNDPEFMSTVPFPPALKNFLLYKEYDVYGRMGEY", "length": 622 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8VHS6-1", "protein_name": "Ankyrin repeat and SOCS box protein 15", "gene_name": "Asb15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDINDDSNDDHLASYDIQLCIQESIEASQAIFHPKRLVQLSDQNRKLVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLNCLLVAVRANRHEIVRLLLSYGANVNCYFMHVNDTRFPSAIQYALNDEIMLRLLLNNGYQVELCFDCMHGNIFGNSFVWSETEEEGLPGWTSCIIKDNPFCEFITVPWMKHLVGGIVRILIDYMDYVPLCAKLKSVLEVQREWPEIRQIIENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ", "length": 583 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXK1-1", "protein_name": "Ankyrin repeat and SOCS box protein 15", "gene_name": "ASB15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT", "length": 588 }, "evidence": [ { "id": "Q8HXA6", "url": "https://omabrowser.org/oma/group/Q8HXA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q8HXA6", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8HXA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 588, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8HXA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8HXA6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8HXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXA6" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 524, "end_pos": 579, "start_aa": "Trp", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HY86-1", "uniprot_ac": "Q8HY86", "uniprot_id": "STAT_BOVIN", "mass": { "chemical_mass": 7093.0, "monoisotopic_mass": 7093.0 }, "refseq": { "ac": "NP_777177", "name": "statherin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777177" }, "gene_names": [ { "name": "STATH", "type": "recommended", "evidence": [ { "id": "Q8HY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ] }, { "name": "STATH", "type": "synonym", "evidence": [ { "id": "NP_777177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777177" } ] } ], "protein_names": [ { "name": "Statherin", "type": "recommended", "evidence": [ { "id": "Q8HY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HY86/entry#names_and_taxonomy" } ] }, { "name": "statherin precursor", "type": "synonym", "evidence": [ { "id": "NP_777177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777177" } ] } ], "function": [ { "annotation": "Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STATH", "url": "https://www.uniprot.org/uniprotkb/Q8HY86", "locus": {} } ], "crossref": [ { "id": "Q8HY86", "url": "https://alphafold.ebi.ac.uk/entry/Q8HY86", "database": "AlphaFoldDB", "categories": [] }, { "id": "286765", "url": "https://www.ncbi.nlm.nih.gov/gene/286765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286765", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286765", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15057", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15057", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15057:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15057:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_777177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HY86-1", "url": "https://www.uniprot.org/uniprotkb/Q8HY86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIFFFAFIMALMVAMIKADSSEEEHRLRFNPRFYYPNQQGGYIPSYPAYPYPYPYPVQ", "length": 59, "header": "sp|Q8HY86-1|STAT_BOVIN Isoform 1 of Statherin OS=Bos taurus OX=9913 GN=STATH PE=3 SV=1 CANONICAL=Q8HY86-1" }, "isoforms": [ { "isoform_ac": "Q8HY86-1", "url": "https://www.uniprot.org/uniprotkb/Q8HY86/entry#Q8HY86-1", "sequence": { "sequence": "MKIFFFAFIMALMVAMIKADSSEEEHRLRFNPRFYYPNQQGGYIPSYPAYPYPYPYPVQ", "length": 59, "header": "sp|Q8HY86-1|STAT_BOVIN Isoform 1 of Statherin OS=Bos taurus OX=9913 GN=STATH PE=3 SV=1 CANONICAL=Q8HY86-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "site_lbl": "Ser21" }, { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "site_lbl": "Ser22" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins.", "journal": "Genomics", "date": "2003", "authors": "Rijnkels M, Elnitski L, Miller W, Rosen JM", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "reference": [ { "type": "PubMed", "id": "13679022", "url": "https://glygen.org/publication/PubMed/13679022" } ] } ], "pathway": [ { "id": "bta:286765", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286765", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" }, { "name": "biomineral tissue development", "id": "GO:0031214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031214", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" }, { "name": "regulation of bone mineralization", "id": "GO:0030500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030500", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydroxyapatite binding", "id": "GO:0046848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046848", "evidence": [ { "database": "UniProtKB", "id": "Q8HY86", "url": "https://www.uniprot.org/uniprotkb/Q8HY86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8HY86-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 59, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8HY86-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8HY86" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 21, 22 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HYW0-1", "uniprot_ac": "Q8HYW0", "uniprot_id": "FA13A_BOVIN", "mass": { "chemical_mass": 80099.0, "monoisotopic_mass": 80099.0 }, "refseq": { "ac": "NP_777117", "name": "protein FAM13A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" }, "gene_names": [ { "name": "FAM13A", "type": "recommended", "evidence": [ { "id": "Q8HYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ] }, { "name": "FAM13A1", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" }, { "id": "Q8HYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ] }, { "name": "FAM13A", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" } ] }, { "name": "PRECM1", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" }, { "id": "Q8HYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ] } ], "protein_names": [ { "name": "Protein FAM13A", "type": "recommended", "evidence": [ { "id": "Q8HYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#names_and_taxonomy" } ] }, { "name": "Protein Precm1", "type": "synonym", "evidence": [ { "id": "Q8HYW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 13, member A1", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" } ] }, { "name": "protein FAM13A", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" } ] }, { "name": "protein Precm1", "type": "synonym", "evidence": [ { "id": "NP_777117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" } ] } ], "function": [ { "annotation": "Study analyzed the gene structure of FAM13A and identified the core promoter region with sites for two key transcription factors, ACSL1 and ASCL2. High expression of FAM13A was found in subcutaneous adipose tissue after lungs, which shows its role in adipogenesis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_777117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" }, { "database": "PubMed", "id": "31795267", "url": "https://glygen.org/publication/PubMed/31795267" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM13A", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0", "locus": { "chromosome": "6", "start_pos": 36031040, "end_pos": 35695188, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011187", "url": "https://www.ensembl.org/id/ENSBTAG00000011187" } ] } } ], "crossref": [ { "id": "Q8HYW0", "url": "https://alphafold.ebi.ac.uk/entry/Q8HYW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011187", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011187", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04393", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04393", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282605", "url": "https://www.ncbi.nlm.nih.gov/gene/282605", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282605", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282605", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MAP3", "url": "https://www.orthodb.org/?gene=A0A3Q1MAP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MB40", "url": "https://www.orthodb.org/?gene=A0A3Q1MB40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLZ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MLZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTN1", "url": "https://www.orthodb.org/?gene=A0A3Q1MTN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N0X8", "url": "https://www.orthodb.org/?gene=A0A3Q1N0X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NBJ7", "url": "https://www.orthodb.org/?gene=A0A3Q1NBJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ77", "url": "https://www.orthodb.org/?gene=A0A452DJ77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8HYW0", "url": "https://www.orthodb.org/?gene=Q8HYW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15904", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15904", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15904:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15904:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26116", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26116", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB40", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB40-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0X8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0X8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBJ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ77", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ77-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HYW0-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACEIMPLQSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEMPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 697, "header": "sp|Q8HYW0-1|FA13A_BOVIN Isoform 1 of Protein FAM13A OS=Bos taurus OX=9913 GN=FAM13A PE=2 SV=1 CANONICAL=Q8HYW0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAP3-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1MAP3-1", "sequence": { "sequence": "MTFLCRVVCVLCLLCPDLIFRGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 969, "header": "tr|A0A3Q1MAP3-1|A0A3Q1MAP3_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35742700, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083655.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083655.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067690.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067690.2" } ] } }, { "isoform_ac": "A0A3Q1MB40-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1MB40-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 992, "header": "tr|A0A3Q1MB40-1|A0A3Q1MB40_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077437.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077437.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067862.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067862.2" } ] } }, { "isoform_ac": "A0A3Q1MLZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1MLZ0-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKMKDFPIAQTAKKSACNAGYLGSVPGSEKTSGEGNGSPLQYSCLENPMDRGDWQAVGGMEKSWIRIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 1059, "header": "tr|A0A3Q1MLZ0-1|A0A3Q1MLZ0_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=3 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084800.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084800.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070378.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070378.3" } ] } }, { "isoform_ac": "A0A3Q1MTN1-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1MTN1-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 995, "header": "tr|A0A3Q1MTN1-1|A0A3Q1MTN1_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=1 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071336.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071336.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058041.1" } ] } }, { "isoform_ac": "A0A3Q1N0X8-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1N0X8-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSLCLPVIKHLLKARNSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 1035, "header": "tr|A0A3Q1N0X8-1|A0A3Q1N0X8_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=3 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080745.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080745.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062499.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062499.3" } ] } }, { "isoform_ac": "A0A3Q1NBJ7-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A3Q1NBJ7-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKMKDFPIAQTAKKSACNAGYLGSVPGSEKTSGEGNGSPLQYSCLENPMDRGDWQAVGGMEKSWIRIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 1084, "header": "tr|A0A3Q1NBJ7-1|A0A3Q1NBJ7_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076308.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076308.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068699.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068699.2" } ] } }, { "isoform_ac": "A0A452DJ77-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0A452DJ77-1", "sequence": { "sequence": "MACEIMPLQSLCLPVIKHLLKARNSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 712, "header": "tr|A0A452DJ77-1|A0A452DJ77_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35929317, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014855.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014855.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014855.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014855.6" } ] } }, { "isoform_ac": "A0AAA9SMS7-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0AAA9SMS7-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 815, "header": "tr|A0AAA9SMS7-1|A0AAA9SMS7_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094134.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094134.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087660.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087660.2" } ] } }, { "isoform_ac": "A0AAA9T8X8-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0AAA9T8X8-1", "sequence": { "sequence": "MACEIMPLQSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 697, "header": "tr|A0AAA9T8X8-1|A0AAA9T8X8_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35929317, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134026.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134026.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094437.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094437.2" } ] } }, { "isoform_ac": "A0AAA9TV66-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#A0AAA9TV66-1", "sequence": { "sequence": "MGAGALAICQSKTAVRLKEDMKKIVAVPLHEQRNPTYTKLFGVSLQDLHQQGLTENGVPAIVGSIVEYLTMHGLTQEGLFRVNGNVKVVEQLRWKFESGVPVELGRDGDVCAAASLLKLFLRELPESVITSTLQPRFLQLFQDDRNDAQESNLRALIEELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGVKEQDLCNKIMAKILENYNTLFEVEYMENDNQRCENLARLIIVKEANCKNILLTKDFERDTLKPSPKTKIRKSSSEGSIWTHRVPHPELSEGVPQVSLQLSRRKSCWDDTSSAEDANATKLLSSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 1006, "header": "tr|A0AAA9TV66-1|A0AAA9TV66_BOVIN Computationally mapped isoform of Family with sequence similarity 13 member A OS=Bos taurus OX=9913 GN=FAM13A PE=3 SV=2 CANONICAL=Q8HYW0-1" }, "locus": { "chromosome": "6", "start_pos": 36028220, "end_pos": 35721346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113650.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113650.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101018.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101018.2" } ] } }, { "isoform_ac": "Q8HYW0-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0/entry#Q8HYW0-1", "sequence": { "sequence": "MACEIMPLQSSQEDERPMSPFYLSSAHVSQVSSVSSTGELLERTIRSAVEQHLFDVNSSGGQSSEDSESGASSSSSTSTKQRRRQAKEQDESRHSRDVGRLNKENIPSGFSNLDECMLNACEVEKLYENTSGYIGERGKPKRQKSSSRLSELNENQDGLVNMENLNPTPSHERTGSDHVELISDGSKENEKDGRQSQHLENPTMKIQEHPSLPDSKLQRTPDADDQQESFVSEVPELDLTALCDQKSWEEPIPAFSSWQQESVDADEARLSPQAGRLIRQLLEEDSDPMLSPRFYAYGQSRQYLDDTEMPPSPPNSHPFMRRRSSSLGSYEDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDLPPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAETSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVSKNERQVMKPLYDRYRLVKQILSRASTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDNYTKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVLISKRDTDSKSM", "length": 697, "header": "sp|Q8HYW0-1|FA13A_BOVIN Isoform 1 of Protein FAM13A OS=Bos taurus OX=9913 GN=FAM13A PE=2 SV=1 CANONICAL=Q8HYW0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 168, "start_aa": "Thr", "end_pos": 168, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr168", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "site_lbl": "Ser19" }, { "start_pos": 271, "end_pos": 271, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "site_lbl": "Ser271" }, { "start_pos": 291, "end_pos": 291, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "site_lbl": "Ser291" }, { "start_pos": 401, "end_pos": 401, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "site_lbl": "Ser401" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning and characterization of FAM13A1--a gene near a milk protein QTL on BTA6: evidence for population-wide linkage disequilibrium in Israeli Holsteins.", "journal": "Genomics", "date": "2004", "authors": "Cohen Miri, Reichenstein Moshe, Everts-van der Wind Annelie, Heon-Lee Jun, Shani Moshe, Lewin Harris A, Weller Joel I, Ron Micha, Seroussi Eyal", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "reference": [ { "type": "PubMed", "id": "15234000", "url": "https://glygen.org/publication/PubMed/15234000" } ] }, { "title": "The Molecular Characteristics of the FAM13A Gene and the Role of Transcription Factors ACSL1 and ASCL2 in Its Core Promoter Region.", "journal": "Genes", "date": "2019-11-28", "authors": "Liang Chengcheng, Li Anning, Raza Sayed Haidar Abbas, Khan Rajwali, Wang Xiaoyu, Wang Sihu, Wang Guohua, Zhang Yu, Zan Linsen", "evidence": [ { "database": "RefSeq", "id": "NP_777117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777117" } ], "reference": [ { "type": "PubMed", "id": "31795267", "url": "https://glygen.org/publication/PubMed/31795267" } ] } ], "pathway": [ { "id": "bta:282605", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282605", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q8HYW0", "url": "https://www.uniprot.org/uniprotkb/Q8HYW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8HYW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 697, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8HYW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8HYW0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 168 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 19, 271, 291, 401 ], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8MJD5-1", "uniprot_ac": "Q8MJD5", "uniprot_id": "HOP_BOVIN", "mass": { "chemical_mass": 8299.0, "monoisotopic_mass": 8299.0 }, "refseq": { "ac": "NP_776522", "name": "homeodomain-only protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" }, "gene_names": [ { "name": "HOPX", "type": "recommended", "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ] }, { "name": "HOD", "type": "synonym", "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ] }, { "name": "HOPX", "type": "synonym", "evidence": [ { "id": "NP_776522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" } ] }, { "name": "HOP", "type": "synonym", "evidence": [ { "id": "NP_776522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" }, { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ] }, { "name": "LAGY", "type": "synonym", "evidence": [ { "id": "NP_776522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" } ] }, { "name": "OB1", "type": "synonym", "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ] } ], "protein_names": [ { "name": "Homeodomain-only protein", "type": "recommended", "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5/entry#names_and_taxonomy" } ] }, { "name": "Odd homeobox protein 1", "type": "synonym", "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5/entry#names_and_taxonomy" } ] }, { "name": "homeodomain-only protein", "type": "synonym", "evidence": [ { "id": "NP_776522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" } ] }, { "name": "odd homeobox 1", "type": "synonym", "evidence": [ { "id": "NP_776522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522" } ] } ], "function": [ { "annotation": "Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5#function" }, { "database": "UniProtKB", "id": "Q9BPY8", "url": "https://www.uniprot.org/uniprotkb/Q9BPY8#function" }, { "database": "UniProtKB", "id": "Q8R1H0", "url": "https://www.uniprot.org/uniprotkb/Q8R1H0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOPX", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5", "locus": { "chromosome": "6", "start_pos": 71973666, "end_pos": 71983218, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002333", "url": "https://www.ensembl.org/id/ENSBTAG00000002333" } ] } } ], "crossref": [ { "id": "Q8MJD5", "url": "https://alphafold.ebi.ac.uk/entry/Q8MJD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002333", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002333", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281270", "url": "https://www.ncbi.nlm.nih.gov/gene/281270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281270", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281270", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LRMAKWR", "url": "https://omabrowser.org/oma/group/LRMAKWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8MJD5", "url": "https://www.orthodb.org/?gene=Q8MJD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21408:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21408:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776522", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJD5-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTETASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLSEEETQKWFKQRLAQWRRSEGLPSECRSVTD", "length": 73, "header": "sp|Q8MJD5-1|HOP_BOVIN Isoform 1 of Homeodomain-only protein OS=Bos taurus OX=9913 GN=HOPX PE=3 SV=1 CANONICAL=Q8MJD5-1" }, "isoforms": [ { "isoform_ac": "Q8MJD5-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5/entry#Q8MJD5-1", "sequence": { "sequence": "MSTETASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLSEEETQKWFKQRLAQWRRSEGLPSECRSVTD", "length": 73, "header": "sp|Q8MJD5-1|HOP_BOVIN Isoform 1 of Homeodomain-only protein OS=Bos taurus OX=9913 GN=HOPX PE=3 SV=1 CANONICAL=Q8MJD5-1" }, "locus": { "chromosome": "6", "start_pos": 71982671, "end_pos": 71974398, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003013.4", "url": "https://www.ensembl.org/id/ENSBTAT00000003013.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003013.3", "url": "https://www.ensembl.org/id/ENSBTAP00000003013.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 10, "start_aa": "Thr", "end_pos": 10, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr10", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.", "journal": "Mech. Dev.", "date": "2002", "authors": "Adu J, Leong FT, Smith NR, Leek JP, Markham AF, Robinson PA, Mighell AJ", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "reference": [ { "type": "PubMed", "id": "14516659", "url": "https://glygen.org/publication/PubMed/14516659" } ] } ], "pathway": [ { "id": "bta:281270", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281270", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8AYB8-1", "protein_name": "Homeodomain-only protein", "gene_name": "hopx", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSANGNAALGVRLTEDQVKVLEENFTKVSKHPDETTLMLIAAECGLSEEQTAVWFRMRNAQWRKAEGLPAELGSVKD", "length": 77 }, "evidence": [ { "id": "Q8MJD5", "url": "https://omabrowser.org/oma/group/Q8MJD5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8JHU0-1", "protein_name": "Homeodomain-only protein", "gene_name": "HOPX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATEKSVTPTEEQLEILEYNFCKVNKHPDPTTLCLIAAETGLSEEQTLKWFKQRLAEWRKSEGLPSECGSVRD", "length": 73 }, "evidence": [ { "id": "Q8MJD5", "url": "https://omabrowser.org/oma/group/Q8MJD5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8MJD6-1", "protein_name": "Homeodomain-only protein", "gene_name": "HOPX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAEPANGPTEDQVEILEYNFNKVNRHPDPTTLCLIAAEAGLSEEETQKWFKQRLAQWRRSEGLPSECRSVTD", "length": 73 }, "evidence": [ { "id": "Q8MJD5", "url": "https://omabrowser.org/oma/group/Q8MJD5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8R1H0-1", "protein_name": "Homeodomain-only protein", "gene_name": "Hopx", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAQTASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLTEEQTQKWFKQRLAEWRRSEGLPSECRSVTD", "length": 73 }, "evidence": [ { "id": "Q8MJD5", "url": "https://omabrowser.org/oma/group/Q8MJD5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BPY8-1", "protein_name": "Homeodomain-only protein", "gene_name": "HOPX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSEGLPSECRSVTD", "length": 73 }, "evidence": [ { "id": "Q8MJD5", "url": "https://omabrowser.org/oma/group/Q8MJD5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "histone deacetylase regulator activity", "id": "GO:0035033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035033", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "trophectodermal cell differentiation", "id": "GO:0001829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001829", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "positive regulation of gap junction assembly", "id": "GO:1903598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903598", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" }, { "name": "chaperone-mediated protein complex assembly", "id": "GO:0051131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051131", "evidence": [ { "database": "UniProtKB", "id": "Q8MJD5", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MJD5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 73, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MJD5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MJD5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8MJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJD5" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Homeobox; degenerate", "eco_id": "ECO_0000255", "start_pos": 3, "end_pos": 62, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 10 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q95KE5-1", "uniprot_ac": "Q95KE5", "uniprot_id": "RM43_BOVIN", "mass": { "chemical_mass": 17735.0, "monoisotopic_mass": 17735.0 }, "refseq": { "ac": "NP_776988", "name": "large ribosomal subunit protein mL43", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" }, "gene_names": [ { "name": "MRPL43", "type": "recommended", "evidence": [ { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ] }, { "name": "MRPL43", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL43", "type": "recommended", "evidence": [ { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L43, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" }, { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#names_and_taxonomy" } ] }, { "name": "L43mt", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" }, { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#names_and_taxonomy" } ] }, { "name": "MRP-L43", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" }, { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#names_and_taxonomy" } ] }, { "name": "Retina-specific 15.7 kDa protein", "type": "synonym", "evidence": [ { "id": "Q95KE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL43", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" } ] }, { "name": "retina-specific 15.7 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_776988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" } ] } ], "function": [ { "annotation": "TWINKLE and mitochondrial ribosomal protein L43 genes are regulated by an evolutionary conserved bidirectional promoter.", "evidence": [ { "database": "RefSeq", "id": "NP_776988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" }, { "database": "PubMed", "id": "24361965", "url": "https://glygen.org/publication/PubMed/24361965" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL43", "url": "https://www.uniprot.org/uniprotkb/Q95KE5", "locus": { "chromosome": "26", "start_pos": 21823624, "end_pos": 21824790, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003294", "url": "https://www.ensembl.org/id/ENSBTAG00000003294" } ] } } ], "crossref": [ { "id": "Q95KE5", "url": "https://alphafold.ebi.ac.uk/entry/Q95KE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003294", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003294", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282277", "url": "https://www.ncbi.nlm.nih.gov/gene/282277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282277", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ISKWIDL", "url": "https://omabrowser.org/oma/group/ISKWIDL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q95KE5", "url": "https://www.orthodb.org/?gene=Q95KE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21396", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21396", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21396:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21396:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95KE5-1", "url": "https://www.uniprot.org/uniprotkb/Q95KE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTARGTASRFLTSVLHNGLGRYVQQLQRLSFSLSRDAPSSRGAREFVEREVTDFARRNPGVVIYVNPRPCCVPRVVAEYLNGAVREESLNCKSVEEIATLVQKLADQSGLDVIRIRKPFHTDSPSIQGQWHPFTNKPTALGGLRPREVQNPAPTQRPAQ", "length": 159, "header": "sp|Q95KE5-1|RM43_BOVIN Isoform 1 of Large ribosomal subunit protein mL43 OS=Bos taurus OX=9913 GN=MRPL43 PE=2 SV=2 CANONICAL=Q95KE5-1" }, "isoforms": [ { "isoform_ac": "Q95KE5-1", "url": "https://www.uniprot.org/uniprotkb/Q95KE5/entry#Q95KE5-1", "sequence": { "sequence": "MTARGTASRFLTSVLHNGLGRYVQQLQRLSFSLSRDAPSSRGAREFVEREVTDFARRNPGVVIYVNPRPCCVPRVVAEYLNGAVREESLNCKSVEEIATLVQKLADQSGLDVIRIRKPFHTDSPSIQGQWHPFTNKPTALGGLRPREVQNPAPTQRPAQ", "length": 159, "header": "sp|Q95KE5-1|RM43_BOVIN Isoform 1 of Large ribosomal subunit protein mL43 OS=Bos taurus OX=9913 GN=MRPL43 PE=2 SV=2 CANONICAL=Q95KE5-1" }, "locus": { "chromosome": "26", "start_pos": 21824755, "end_pos": 21824075, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004265.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004265.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004265.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004265.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning and characterization of a cDNA specific for bovine retina.", "journal": "Neurosci. Res.", "date": "1986", "authors": "Nakagawa Y, Kuo C H, Ishii K, Shiosaka S, Tohyama M, Miki N", "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "reference": [ { "type": "PubMed", "id": "2425311", "url": "https://glygen.org/publication/PubMed/2425311" } ] }, { "title": "Bovine TWINKLE and mitochondrial ribosomal protein L43 genes are regulated by an evolutionary conserved bidirectional promoter.", "journal": "Gene", "date": "2014-03-01", "authors": "Meersseman C\u00e9dric, L\u00e9jard V\u00e9ronique, Rebours Emmanuelle, Boussaha Mekki, Maftah Abderrahman, Petit Daniel, Rocha Dominique", "evidence": [ { "database": "RefSeq", "id": "NP_776988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776988" } ], "reference": [ { "type": "PubMed", "id": "24361965", "url": "https://glygen.org/publication/PubMed/24361965" } ] } ], "pathway": [ { "id": "bta:282277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282277", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXF8-1", "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "Mrpl43", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTARGTPSRFLTSVLHNGLGRYVQQLQRLSLTLSRDAPSSRGAREFVEREVTDFARRNPGVVIYLNPRPCAVPRIVAEYLNGAVREENVNSKSVEEITSLVQKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKRTTFHGLRPRELQDSAPASI", "length": 156 }, "evidence": [ { "id": "Q95KE5", "url": "https://omabrowser.org/oma/group/Q95KE5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q06090-1", "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "MRPL51", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVVKAIARNSIGRNGVGAFVFPCRKITLQFCNWGGSSEGMRKFLTSKRLDKWGQEFPWIQFEVMRKSGHPLLRAEYTNGREKVICVRNLNIDNVENKLKLLKDSDGDILRRRTKNDNVESLNSSVRGIWSPLHAAKRHRI", "length": 140 }, "evidence": [ { "id": "Q95KE5", "url": "https://omabrowser.org/oma/group/Q95KE5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54RB6-1", "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKNGVWQLKKLAINYCEFSGSSKYVRNILNSKVEKFKSVNPQIEFEYKVNRGSHPYLIATYESGVTKTVPLRGRTEEKVLKHIQNLKDTSGEKPRKFGDRYISKTESIQGLWNPFINFSNSEQ", "length": 124 }, "evidence": [ { "id": "Q95KE5", "url": "https://omabrowser.org/oma/group/Q95KE5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8N983-1", "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "MRPL43", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREVIDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLVQKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQDPAPAQDTGLRLSAVAPQILLPGWPDPPDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA", "length": 215 }, "evidence": [ { "id": "Q95KE5", "url": "https://omabrowser.org/oma/group/Q95KE5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W1L1-1", "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "mRpL43", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNSHLFLKSGFPRAPLQNGLGRYVCQLQRITLKFCKNNGSSRGMRDFIENHLLDFAKENPGIVVYVKPRRHRTPVLVGEYLNGEREWMSCRNSTQEEISKWIDLLKTQNGSSSSLRLRKMWHTEVPSIQGPWTPFLLRSPDAQGQAYPSAEASKPLDTPQTATEKLIELFRQQQLEAGEEAHDVLNKKRAE", "length": 192 }, "evidence": [ { "id": "Q95KE5", "url": "https://omabrowser.org/oma/group/Q95KE5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q95KE5", "url": "https://www.uniprot.org/uniprotkb/Q95KE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q95KE5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 159, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q95KE5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q95KE5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q95LI3-1", "uniprot_ac": "Q95LI3", "uniprot_id": "ZFY_BOVIN", "mass": { "chemical_mass": 90344.0, "monoisotopic_mass": 90344.0 }, "refseq": { "ac": "NP_803457", "name": "zinc finger Y-chromosomal protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" }, "gene_names": [ { "name": "ZFY", "type": "recommended", "evidence": [ { "id": "Q95LI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ] }, { "name": "ZFY", "type": "synonym", "evidence": [ { "id": "NP_803457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" } ] } ], "protein_names": [ { "name": "Zinc finger Y-chromosomal protein", "type": "recommended", "evidence": [ { "id": "Q95LI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95LI3/entry#names_and_taxonomy" } ] }, { "name": "Y-linked zinc finger protein", "type": "synonym", "evidence": [ { "id": "NP_803457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" } ] }, { "name": "zinc finger Y-chromosomal protein", "type": "synonym", "evidence": [ { "id": "NP_803457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" } ] } ], "function": [ { "annotation": "Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3#function" } ] }, { "annotation": "The Zfy gene plays a role in the process of Y-sperm formation, and Zfy siRNA is a potential useful approach to control sex of offspring in cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_803457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" }, { "database": "PubMed", "id": "30377028", "url": "https://glygen.org/publication/PubMed/30377028" } ] }, { "annotation": "ZFY transcripts were detected in unsexed pools of 8-16-cell stage embryos and in male blastocysts.", "evidence": [ { "database": "RefSeq", "id": "NP_803457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" }, { "database": "PubMed", "id": "12356942", "url": "https://glygen.org/publication/PubMed/12356942" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFY", "url": "https://www.uniprot.org/uniprotkb/Q95LI3", "locus": {} } ], "crossref": [ { "id": "Q95LI3", "url": "https://alphafold.ebi.ac.uk/entry/Q95LI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "280962", "url": "https://www.ncbi.nlm.nih.gov/gene/280962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:280962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_803457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95LI3-1", "url": "https://www.uniprot.org/uniprotkb/Q95LI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEDEFELQPQEPNSCFDGIGTDATHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIENVVIEDVQCSDILEEADVSENVIIPEQMLSSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESVHVSDVGHVEHIVHGSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDDGKMEHDCSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRMPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAAAATTVHEQEMDDSEIKTFMPIAWAAAYGNNSDGIENRSGTASALLHIDESAGLGRLTKHKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKSEKAIECDDCGKHFSHAGALFTHKMVHKEKGASKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMSFKCDICLLTFSDTKEVQQHALIHQESKTHQCVHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCKKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHITRHHKEVGLP", "length": 801, "header": "sp|Q95LI3-1|ZFY_BOVIN Isoform 1 of Zinc finger Y-chromosomal protein OS=Bos taurus OX=9913 GN=ZFY PE=2 SV=1 CANONICAL=Q95LI3-1" }, "isoforms": [ { "isoform_ac": "Q95LI3-1", "url": "https://www.uniprot.org/uniprotkb/Q95LI3/entry#Q95LI3-1", "sequence": { "sequence": "MDEDEFELQPQEPNSCFDGIGTDATHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIENVVIEDVQCSDILEEADVSENVIIPEQMLSSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESVHVSDVGHVEHIVHGSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDDGKMEHDCSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRMPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAAAATTVHEQEMDDSEIKTFMPIAWAAAYGNNSDGIENRSGTASALLHIDESAGLGRLTKHKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKSEKAIECDDCGKHFSHAGALFTHKMVHKEKGASKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMSFKCDICLLTFSDTKEVQQHALIHQESKTHQCVHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCKKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHITRHHKEVGLP", "length": 801, "header": "sp|Q95LI3-1|ZFY_BOVIN Isoform 1 of Zinc finger Y-chromosomal protein OS=Bos taurus OX=9913 GN=ZFY PE=2 SV=1 CANONICAL=Q95LI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 269, "end_pos": 269, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "site_lbl": "Ser269" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Sex-chromosome linked gene expression in in-vitro produced bovine embryos.", "journal": "Molecular human reproduction", "date": "2002-10", "authors": "Peippo J, Farazmand A, Kurkilahti M, Markkula M, Basrur P K, King W A", "evidence": [ { "database": "RefSeq", "id": "NP_803457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" } ], "reference": [ { "type": "PubMed", "id": "12356942", "url": "https://glygen.org/publication/PubMed/12356942" } ] }, { "title": "Sex control by Zfy siRNA in the dairy cattle.", "journal": "Animal reproduction science", "date": "2019-01", "authors": "Xi Ji-Feng, Wang Xiang-Zu, Zhang Yong-Sheng, Jia Bin, Li Chao-Cheng, Wang Xu-Hai, Ying Rui-Wen", "evidence": [ { "database": "RefSeq", "id": "NP_803457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803457" } ], "reference": [ { "type": "PubMed", "id": "30377028", "url": "https://glygen.org/publication/PubMed/30377028" } ] } ], "pathway": [ { "id": "bta:280962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280962", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q95LI3", "url": "https://www.uniprot.org/uniprotkb/Q95LI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q95LI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 801, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q95LI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q95LI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 269 ], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 640, "end_pos": 642 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q9MYV9-1", "uniprot_ac": "Q9MYV9", "uniprot_id": "TRPC5_BOVIN", "mass": { "chemical_mass": 111606.0, "monoisotopic_mass": 111606.0 }, "refseq": { "ac": "NP_001160046", "name": "short transient receptor potential channel 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" }, "gene_names": [ { "name": "TRPC5", "type": "recommended", "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ] }, { "name": "TRP5", "type": "synonym", "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ] }, { "name": "TRPC5", "type": "synonym", "evidence": [ { "id": "NP_001160046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ] }, { "name": "trp", "type": "synonym", "evidence": [ { "id": "NP_001160046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ] } ], "protein_names": [ { "name": "Short transient receptor potential channel 5", "type": "recommended", "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9/entry#names_and_taxonomy" } ] }, { "name": "TrpC5", "type": "synonym", "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9/entry#names_and_taxonomy" } ] }, { "name": "short transient receptor potential channel 5", "type": "synonym", "evidence": [ { "id": "NP_001160046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ] }, { "name": "transient receptor potential channel 5", "type": "synonym", "evidence": [ { "id": "NP_001160046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ] } ], "function": [ { "annotation": "Analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement", "evidence": [ { "database": "RefSeq", "id": "NP_001160046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" }, { "database": "PubMed", "id": "18495872", "url": "https://glygen.org/publication/PubMed/18495872" } ] }, { "annotation": "Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:10816590). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization and maternal care (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "database": "UniProtKB", "id": "Q9UL62", "url": "https://www.uniprot.org/uniprotkb/Q9UL62#function" }, { "database": "UniProtKB", "id": "Q9QX29", "url": "https://www.uniprot.org/uniprotkb/Q9QX29#function" }, { "database": "PubMed", "id": "10816590", "url": "https://glygen.org/publication/PubMed/10816590" } ] }, { "annotation": "Nitrix oxide can negatively modulate endogenous TRPC5-containing channels through an indirect mechanism.", "evidence": [ { "database": "RefSeq", "id": "NP_001160046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" }, { "database": "PubMed", "id": "20390293", "url": "https://glygen.org/publication/PubMed/20390293" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPC5", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9", "locus": { "chromosome": "X", "start_pos": 59974309, "end_pos": 60323435, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010065", "url": "https://www.ensembl.org/id/ENSBTAG00000010065" } ] } } ], "crossref": [ { "id": "Q9MYV9", "url": "https://alphafold.ebi.ac.uk/entry/Q9MYV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407103", "url": "https://www.ncbi.nlm.nih.gov/gene/407103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCKWIHK", "url": "https://omabrowser.org/oma/group/LCKWIHK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9MYV9", "url": "https://www.orthodb.org/?gene=Q9MYV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117:SF76", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF76", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001160046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MYV9-1", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHQRRSFSTSSTELSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGPPLIRTMPRVGGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQPHYMWQDIRYSQMEKGKAEACSQSEINLSEVELGEARGTAQSTECPLACSSSLHCVSSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL", "length": 974, "header": "sp|Q9MYV9-1|TRPC5_BOVIN Isoform 1 of Short transient receptor potential channel 5 OS=Bos taurus OX=9913 GN=TRPC5 PE=2 SV=2 CANONICAL=Q9MYV9-1" }, "isoforms": [ { "isoform_ac": "Q9MYV9-1", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9/entry#Q9MYV9-1", "sequence": { "sequence": "MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHQRRSFSTSSTELSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGPPLIRTMPRVGGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQPHYMWQDIRYSQMEKGKAEACSQSEINLSEVELGEARGTAQSTECPLACSSSLHCVSSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL", "length": 974, "header": "sp|Q9MYV9-1|TRPC5_BOVIN Isoform 1 of Short transient receptor potential channel 5 OS=Bos taurus OX=9913 GN=TRPC5 PE=2 SV=2 CANONICAL=Q9MYV9-1" }, "locus": { "chromosome": "X", "start_pos": 60163751, "end_pos": 59975313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013270.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013270.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013270.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013270.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells.", "journal": "The Journal of biological chemistry", "date": "2000-08-04", "authors": "Philipp S, Trost C, Warnat J, Rautmann J, Himmerkus N, Schroth G, Kretz O, Nastainczyk W, Cavalie A, Hoth M, Flockerzi V", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "reference": [ { "type": "PubMed", "id": "10816590", "url": "https://glygen.org/publication/PubMed/10816590" } ] }, { "title": "Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement.", "journal": "Molecular biology of the cell", "date": "2008-08", "authors": "Chaudhuri Pinaki, Colles Scott M, Bhat Manjunatha, Van Wagoner David R, Birnbaumer Lutz, Graham Linda M", "evidence": [ { "database": "RefSeq", "id": "NP_001160046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ], "reference": [ { "type": "PubMed", "id": "18495872", "url": "https://glygen.org/publication/PubMed/18495872" } ] }, { "title": "Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells.", "journal": "Pflugers Archiv : European journal of physiology", "date": "2010-06", "authors": "Wong Ching-On, Sukumar Piruthivi, Beech David J, Yao Xiaoqiang", "evidence": [ { "database": "RefSeq", "id": "NP_001160046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160046" } ], "reference": [ { "type": "PubMed", "id": "20390293", "url": "https://glygen.org/publication/PubMed/20390293" } ] } ], "pathway": [ { "id": "bta:407103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407103", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuron apoptotic process", "id": "GO:0051402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "pmid": "" }, { "name": "phosphatidylserine exposure on apoptotic cell surface", "id": "GO:0070782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070782", "evidence": [ { "database": "UniProtKB", "id": "Q9MYV9", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 678, "end_pos": 680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 901, "end_pos": 903, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9MYV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 974, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9MYV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9MYV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 172, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 172, "end_pos": 172, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 176, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 176, "end_pos": 176, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 178, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 178, "end_pos": 178, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 181, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 181, "end_pos": 181, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 418, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 418, "end_pos": 418, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 421, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 421, "end_pos": 421, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 436, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 436, "end_pos": 436, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9#function" }, { "id": "Q9MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYV9" } ], "binding_site_uniprot": 439, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 439, "end_pos": 439, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 461, "end_pos": 463 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 678, "end_pos": 680 }, { "start_pos": 901, "end_pos": 903 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q9MZG3-1", "uniprot_ac": "Q9MZG3", "uniprot_id": "DBIL5_BOVIN", "mass": { "chemical_mass": 9788.0, "monoisotopic_mass": 9788.0 }, "refseq": { "ac": "NP_847892", "name": "diazepam-binding inhibitor-like 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892" }, "gene_names": [ { "name": "DBIL5", "type": "recommended", "evidence": [ { "id": "Q9MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ] }, { "name": "DBIL5", "type": "synonym", "evidence": [ { "id": "NP_847892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892" } ] }, { "name": "ELP", "type": "synonym", "evidence": [ { "id": "NP_847892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892" } ] } ], "protein_names": [ { "name": "Diazepam-binding inhibitor-like 5", "type": "recommended", "evidence": [ { "id": "Q9MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3/entry#names_and_taxonomy" } ] }, { "name": "ELP", "type": "synonym", "evidence": [ { "id": "Q9MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3/entry#names_and_taxonomy" } ] }, { "name": "Endozepine-like peptide", "type": "synonym", "evidence": [ { "id": "Q9MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3/entry#names_and_taxonomy" } ] }, { "name": "diazepam-binding inhibitor-like 5", "type": "synonym", "evidence": [ { "id": "NP_847892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892" } ] }, { "name": "endozepine-like protein", "type": "synonym", "evidence": [ { "id": "NP_847892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892" } ] } ], "function": [ { "annotation": "May be involved in the energy metabolism of the mature sperm.", "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DBIL5", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3", "locus": { "chromosome": "19", "start_pos": 22088595, "end_pos": 22089914, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013395", "url": "https://www.ensembl.org/id/ENSBTAG00000013395" } ] } } ], "crossref": [ { "id": "Q9MZG3", "url": "https://alphafold.ebi.ac.uk/entry/Q9MZG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013395", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013395", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "353112", "url": "https://www.ncbi.nlm.nih.gov/gene/353112", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000582", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000582", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:353112", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353112", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDCNIPV", "url": "https://omabrowser.org/oma/group/GDCNIPV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9MZG3", "url": "https://www.orthodb.org/?gene=Q9MZG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23310", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23310", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23310:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23310:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00887", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00887", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_847892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847892", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZG3-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCQVEFEMACAAIKQLKGPVSDQEKLLVYSYYKQATQGDCNIPAPPATDLKAKAKWEAWNENKGMSKMDAMRIYIAKVEELKKNEAG", "length": 87, "header": "sp|Q9MZG3-1|DBIL5_BOVIN Isoform 1 of Diazepam-binding inhibitor-like 5 OS=Bos taurus OX=9913 GN=DBIL5 PE=2 SV=1 CANONICAL=Q9MZG3-1" }, "isoforms": [ { "isoform_ac": "Q9MZG3-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3/entry#Q9MZG3-1", "sequence": { "sequence": "MCQVEFEMACAAIKQLKGPVSDQEKLLVYSYYKQATQGDCNIPAPPATDLKAKAKWEAWNENKGMSKMDAMRIYIAKVEELKKNEAG", "length": 87, "header": "sp|Q9MZG3-1|DBIL5_BOVIN Isoform 1 of Diazepam-binding inhibitor-like 5 OS=Bos taurus OX=9913 GN=DBIL5 PE=2 SV=1 CANONICAL=Q9MZG3-1" }, "locus": { "chromosome": "19", "start_pos": 22088998, "end_pos": 22088738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017822.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017822.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017822.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017822.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution.", "journal": "Gene", "date": "2000", "authors": "Ivell R, Pusch W, Balvers M, Valentin M, Walther N, Weinbauer G", "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ], "reference": [ { "type": "PubMed", "id": "11024294", "url": "https://glygen.org/publication/PubMed/11024294" } ] } ], "pathway": [ { "id": "bta:353112", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353112", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FAB6-1", "protein_name": "Diazepam-binding inhibitor-like 5", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCQVEFEMACAAIKQLKGPVSDKEKLLVYSFYKQATQGDCNIPAPSATDVKAKAKWEAWNGNKGMSKMDAMRLYVAKVEELKKNEAG", "length": 87 }, "evidence": [ { "id": "Q9MZG3", "url": "https://omabrowser.org/oma/group/Q9MZG3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HTG7-1", "protein_name": "Diazepam-binding inhibitor-like 5", "gene_name": "LOC100763983", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQVEFEMACASLKQLKGPVSDQEKLLVYSFYKQATQGDCNIPVPPATDVRAKAKWEAWNVNKGMSKMDAMRIYIAKVEELKKNEAG", "length": 87 }, "evidence": [ { "id": "Q9MZG3", "url": "https://omabrowser.org/oma/group/Q9MZG3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O09035-1", "protein_name": "Diazepam-binding inhibitor-like 5", "gene_name": "Dbil5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQVEFEMACASLKQLKGPVSDQEKLLVYSFYKQATQGDCNIPVPPATDVRAKAKYEAWMVNKGMSKMDAMRIYIAKVEELKKKEPC", "length": 87 }, "evidence": [ { "id": "Q9MZG3", "url": "https://omabrowser.org/oma/group/Q9MZG3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "fatty-acyl-CoA binding", "id": "GO:0000062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000062", "evidence": [ { "database": "UniProtKB", "id": "Q9MZG3", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9MZG3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 87, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9MZG3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9MZG3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZG3" }, { "id": "PRU00573", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00573" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ACB", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 87, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q9N0T1-1", "uniprot_ac": "Q9N0T1", "uniprot_id": "STC1_BOVIN", "mass": { "chemical_mass": 27555.0, "monoisotopic_mass": 27555.0 }, "refseq": { "ac": "NP_788842", "name": "stanniocalcin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, "gene_names": [ { "name": "STC1", "type": "recommended", "evidence": [ { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ] }, { "name": "STC1", "type": "synonym", "evidence": [ { "id": "NP_788842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ] }, { "name": "STC", "type": "synonym", "evidence": [ { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ] } ], "protein_names": [ { "name": "Stanniocalcin-1", "type": "recommended", "evidence": [ { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1/entry#names_and_taxonomy" } ] }, { "name": "STC-1", "type": "synonym", "evidence": [ { "id": "NP_788842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1/entry#names_and_taxonomy" } ] }, { "name": "stanniocalcin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_788842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ] } ], "function": [ { "annotation": "Once removed from their normal context within the ovary, luteal cells are capable of synthesizing and secreting big STC.", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, { "database": "PubMed", "id": "15192041", "url": "https://glygen.org/publication/PubMed/15192041" } ] }, { "annotation": "Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, { "database": "PubMed", "id": "24962416", "url": "https://glygen.org/publication/PubMed/24962416" } ] }, { "annotation": "STC-1 in milk is increased following milk stasis", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, { "database": "PubMed", "id": "19389957", "url": "https://glygen.org/publication/PubMed/19389957" } ] }, { "annotation": "Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.", "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1#function" } ] }, { "annotation": "Theca cell-derived big STC is targeted to the cholesterol/lipid storage droplets of luteal cells to regulate steroidogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" }, { "database": "PubMed", "id": "14512426", "url": "https://glygen.org/publication/PubMed/14512426" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STC1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1", "locus": { "chromosome": "8", "start_pos": 70977521, "end_pos": 70990673, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001687", "url": "https://www.ensembl.org/id/ENSBTAG00000001687" } ] } } ], "crossref": [ { "id": "Q9N0T1", "url": "https://alphafold.ebi.ac.uk/entry/Q9N0T1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "338078", "url": "https://www.ncbi.nlm.nih.gov/gene/338078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:338078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MCSIAKR", "url": "https://omabrowser.org/oma/group/MCSIAKR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9N0T1", "url": "https://www.orthodb.org/?gene=Q9N0T1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11245:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11245:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03298", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03298", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N0T1-1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQNSAVLLVLVISASATHEAEQNDSVSLRKSRVAAQNSAEVIRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYTKLNVCSVAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLDCDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAHTQQRADFNRRRANEPQKLKVLLRNLRGEVASPSHIKRTSQESA", "length": 247, "header": "sp|Q9N0T1-1|STC1_BOVIN Isoform 1 of Stanniocalcin-1 OS=Bos taurus OX=9913 GN=STC1 PE=2 SV=2 CANONICAL=Q9N0T1-1" }, "isoforms": [ { "isoform_ac": "Q9N0T1-1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1/entry#Q9N0T1-1", "sequence": { "sequence": "MLQNSAVLLVLVISASATHEAEQNDSVSLRKSRVAAQNSAEVIRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYTKLNVCSVAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLDCDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAHTQQRADFNRRRANEPQKLKVLLRNLRGEVASPSHIKRTSQESA", "length": 247, "header": "sp|Q9N0T1-1|STC1_BOVIN Isoform 1 of Stanniocalcin-1 OS=Bos taurus OX=9913 GN=STC1 PE=2 SV=2 CANONICAL=Q9N0T1-1" }, "locus": { "chromosome": "8", "start_pos": 70990436, "end_pos": 70978994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002200.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002200.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002200.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002200.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 24, "start_aa": "Asn", "end_pos": 24, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn24", "evidence": [ { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 62, "start_aa": "Asn", "end_pos": 62, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn62", "evidence": [ { "id": "Q9N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Targeting of big stanniocalcin and its receptor to lipid storage droplets of ovarian steroidogenic cells.", "journal": "The Journal of biological chemistry", "date": "2003-12-05", "authors": "Paciga Mark, McCudden Christopher R, Londos Constantine, DiMattia Gabriel E, Wagner Graham F", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ], "reference": [ { "type": "PubMed", "id": "14512426", "url": "https://glygen.org/publication/PubMed/14512426" } ] }, { "title": "Regulation of luteal cell big stanniocalcin production and secretion.", "journal": "Endocrinology", "date": "2004-09", "authors": "Paciga Mark, DiMattia Gabriel E, Wagner Graham F", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ], "reference": [ { "type": "PubMed", "id": "15192041", "url": "https://glygen.org/publication/PubMed/15192041" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Local control of mammary involution: is stanniocalcin-1 involved?", "journal": "Journal of dairy science", "date": "2009-05", "authors": "Tremblay G, Bernier-Dodier P, Delbecchi L, Wagner G F, Talbot B G, Lacasse P", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ], "reference": [ { "type": "PubMed", "id": "19389957", "url": "https://glygen.org/publication/PubMed/19389957" } ] }, { "title": "Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage.", "journal": "Journal of veterinary science", "date": "2014-12", "authors": "Wu Li-ming, Guo Rui, Hui Lin, Ye Yong-gang, Xiang Jing-mei, Wan Chun-yun, Zou Miao, Ma Rui, Sun Xiao-zhuan, Yang Shi-jin, Guo Ding-zong", "evidence": [ { "database": "RefSeq", "id": "NP_788842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788842" } ], "reference": [ { "type": "PubMed", "id": "24962416", "url": "https://glygen.org/publication/PubMed/24962416" } ] } ], "pathway": [ { "id": "bta:338078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338078", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z8N6-1", "protein_name": "Stanniocalcin 1", "gene_name": "STC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLKSGLLLLLVISASASYEAEQNDSVSPRKPRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMISEVQEECYSKLDMCGIAKRNPEAITEVVQLPNQFSNRYYNKLVRSLLECDEETVSTIKDSLMEKIGPNMASLFHLLQTDHCAQGHPRTDFARRRITEPQKLKLYFRNLRASANRTRAGPTAADGGLPPTPLSAQ", "length": 255 }, "evidence": [ { "id": "Q9N0T1", "url": "https://omabrowser.org/oma/group/Q9N0T1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GUZ7-1", "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLQNSAVILVLVISAAATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVRTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSHESA", "length": 247 }, "evidence": [ { "id": "Q9N0T1", "url": "https://omabrowser.org/oma/group/Q9N0T1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O55183-1", "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQESA", "length": 247 }, "evidence": [ { "id": "Q9N0T1", "url": "https://omabrowser.org/oma/group/Q9N0T1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P52823-1", "protein_name": "Stanniocalcin-1", "gene_name": "STC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIKRTSHESA", "length": 247 }, "evidence": [ { "id": "Q9N0T1", "url": "https://omabrowser.org/oma/group/Q9N0T1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97574-1", "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQENA", "length": 247 }, "evidence": [ { "id": "Q9N0T1", "url": "https://omabrowser.org/oma/group/Q9N0T1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q9N0T1", "url": "https://www.uniprot.org/uniprotkb/Q9N0T1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9N0T1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9N0T1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9N0T1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 24, 62 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q9N287-1", "uniprot_ac": "Q9N287", "uniprot_id": "DJC12_BOVIN", "mass": { "chemical_mass": 23269.0, "monoisotopic_mass": 23269.0 }, "refseq": { "ac": "NP_776521", "name": "dnaJ homolog subfamily C member 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" }, "gene_names": [ { "name": "DNAJC12", "type": "recommended", "evidence": [ { "id": "Q9N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ] }, { "name": "DNAJC12", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" } ] }, { "name": "JDP1", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" }, { "id": "Q9N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 12", "type": "recommended", "evidence": [ { "id": "Q9N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N287/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 12", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" } ] }, { "name": "J domain containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" } ] }, { "name": "J domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q9N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N287/entry#names_and_taxonomy" } ] }, { "name": "dnaJ homolog subfamily C member 12", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" } ] }, { "name": "j domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_776521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521" } ] } ], "function": [ { "annotation": "Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2).", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287#function" }, { "database": "UniProtKB", "id": "Q9UKB3", "url": "https://www.uniprot.org/uniprotkb/Q9UKB3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC12", "url": "https://www.uniprot.org/uniprotkb/Q9N287", "locus": { "chromosome": "28", "start_pos": 24248426, "end_pos": 24296594, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010932", "url": "https://www.ensembl.org/id/ENSBTAG00000010932" } ] } } ], "crossref": [ { "id": "Q9N287", "url": "https://alphafold.ebi.ac.uk/entry/Q9N287", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010932", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010932", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281259", "url": "https://www.ncbi.nlm.nih.gov/gene/281259", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281259", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281259", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HWAVRDK", "url": "https://omabrowser.org/oma/group/HWAVRDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9N287", "url": "https://www.orthodb.org/?gene=Q9N287", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44500", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44500", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44500:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44500:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776521", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N287-1", "url": "https://www.uniprot.org/uniprotkb/Q9N287-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI", "length": 198, "header": "sp|Q9N287-1|DJC12_BOVIN Isoform 1 of DnaJ homolog subfamily C member 12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=2 SV=1 CANONICAL=Q9N287-1" }, "isoforms": [ { "isoform_ac": "Q9N287-1", "url": "https://www.uniprot.org/uniprotkb/Q9N287/entry#Q9N287-1", "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI", "length": 198, "header": "sp|Q9N287-1|DJC12_BOVIN Isoform 1 of DnaJ homolog subfamily C member 12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=2 SV=1 CANONICAL=Q9N287-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "site_lbl": "Ser160" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "site_lbl": "Ser166" }, { "start_pos": 182, "end_pos": 182, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "site_lbl": "Ser182" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths.", "journal": "Biochim. Biophys. Acta", "date": "2000", "authors": "Lee J, Hahn Y, Yun J H, Mita K, Chung J H", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "reference": [ { "type": "PubMed", "id": "10760603", "url": "https://glygen.org/publication/PubMed/10760603" } ] } ], "pathway": [ { "id": "bta:281259", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281259", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C6F1-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "DNAJC12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDAILNCRLDELEDYYNLLGCDELSTVEQILAEFKIKALECHPDKHPGNPKAVENFQKLQQAKEVLIHEESRARYDYWRRSKITIPFQEWEALSSSVKTSMHWAVQNKKDQMLEAPDLNNSNNLTNEIWTQKTENDEDGLSDGNREQDVAIPDVKPQSSKNPDSPRFSEANYWHLRFRWSGDAPSDLLRKFRNYEI", "length": 196 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F5S9-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "dnajc12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEAILNCRKEDLEDYYGLLGCDELSTTEQIVNEFKVKALACHPDKHPENPKAVEQFQKLQEAKEVLTDEKKRKSYDLWLRSQIKIPFGEWRALSDSVKTSMHWAVKAKKEPMLEAAEDSNPSDENTVQEKPSEASLPSSDYWHQRFRWAGEAPTGLLQKFRNYEI", "length": 165 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HAB2-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "Dnajc12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDAILNYRPEGTEDYYALLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKEILTNAESRARYDHWRRSQMSMPFEQWDALADSVKTSMHWAVRSKKDLMLEGMDQTYTNTVQNKEQNEQRETKKGEPDSTTEKTRQKESGSPEKAIAPQNPGSPDLNCGHLRFRWSGDPPSELLRKFRNYEI", "length": 195 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q925T0-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "Dnajc12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAILNYRPEGSEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKEILSNAESRARYDHWRRSQMSMSFEQWEALADSVKTSMHWAVRSKKDLMLEGSEQTYTNTAQNKERSEQRETKQGDPDSTPEKMMQKESESPEKGISPQNPDSPGLSDWNCGHLHFRWSGDTPSELLRKFRNYEI", "length": 198 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9R022-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "Dnajc12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAILNYRPEGSEDYYALLGCDELSSVEQILAEFKIRALECHPDKHPENSKAVETFQKLQKAKEILCNAESRARYDHWRRSQMSMPFEQWEALADSVKTSMHWAVRSKKDLMLEGSGQTFTSSVPNKERSEQRETKKGDPDSNPEKMKQKEPKFPEEGISPQNPDSPGLSDLNCGHLRFRWSGDAPSELLRKFRNYEI", "length": 198 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9TVP3-1", "protein_name": "J domain-containing protein", "gene_name": "jdp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAVDAIINYKRSPNEDFYGLLHCDENSSPEQIQAEYKVLALQYHPDKNSGDKEAEAKFQQLKEAKETLCDPEKRAIYDKWRNSGISMSYKQWLGMKEHVGQVRRYTIAEKVDKESMHWVTPKTKDRMLPETGGAAAQGPGTGAGCSSGGLTAASPNPAHRRASEGGAALYYGSRKGEWGGENTDVANKFRNYEI", "length": 195 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9UKB3-1", "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "DNAJC12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAILNYRSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENPKAVETFQKLQKAKEILTNEESRARYDHWRRSQMSMPFQQWEALNDSVKTSMHWVVRGKKDLMLEESDKTHTTKMENEECNEQRERKKEELASTAEKTEQKEPKPLEKSVSPQNSDSSGFADVNGWHLRFRWSKDAPSELLRKFRNYEI", "length": 198 }, "evidence": [ { "id": "Q9N287", "url": "https://omabrowser.org/oma/group/Q9N287/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9N287", "url": "https://www.uniprot.org/uniprotkb/Q9N287" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9N287-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9N287-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9N287" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N287" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 14, "end_pos": 79, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 160, 166, 182 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BCS6-1", "uniprot_ac": "E1BCS6", "uniprot_id": "E1BCS6_BOVIN", "mass": { "chemical_mass": 32021.0, "monoisotopic_mass": 32021.0 }, "refseq": {}, "gene_names": [ { "name": "SAMD10", "type": "recommended", "evidence": [ { "id": "E1BCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCS6" } ] } ], "protein_names": [ { "name": "Sterile alpha motif domain containing 10", "type": "synonym", "evidence": [ { "id": "E1BCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCS6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCS6", "url": "https://www.uniprot.org/uniprotkb/E1BCS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAMD10", "url": "https://www.uniprot.org/uniprotkb/E1BCS6", "locus": { "chromosome": "13", "start_pos": 53877526, "end_pos": 53872788, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011655", "url": "https://www.ensembl.org/id/ENSBTAG00000011655" } ] } } ], "crossref": [ { "id": "E1BCS6", "url": "https://alphafold.ebi.ac.uk/entry/E1BCS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011655", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011655", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCS6", "url": "https://www.orthodb.org/?gene=E1BCS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20843", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20843", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20843:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20843:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCS6", "url": "https://www.uniprot.org/uniprotkb/E1BCS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCS6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRCARPPLALAAALRAPRSARRRHPSELPERARLSGLSGRCLAAQTRRARGPAQARGRLGRGGGARSPPATRAALRPARGVCTGGALAGPMFTELRTKPSPPRGRAGAVRSGFGERRDVDATAHFNFCRSLLDHTVSAENIPCPLPRTPGTSLTWHDSRSQRAAGGRPVKLLQQPGTEAPQGRLYSDHYGLYHTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNAEKLQRMGLAQEAQRQEVLQQLLHLQVREEGRSLQLLSQASFGNMS", "length": 293, "header": "tr|E1BCS6-1|E1BCS6_BOVIN Isoform 1 of Sterile alpha motif domain containing 10 OS=Bos taurus OX=9913 GN=SAMD10 PE=4 SV=4 CANONICAL=E1BCS6-1" }, "isoforms": [ { "isoform_ac": "E1BCS6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCS6/entry#E1BCS6-1", "sequence": { "sequence": "MPRCARPPLALAAALRAPRSARRRHPSELPERARLSGLSGRCLAAQTRRARGPAQARGRLGRGGGARSPPATRAALRPARGVCTGGALAGPMFTELRTKPSPPRGRAGAVRSGFGERRDVDATAHFNFCRSLLDHTVSAENIPCPLPRTPGTSLTWHDSRSQRAAGGRPVKLLQQPGTEAPQGRLYSDHYGLYHTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNAEKLQRMGLAQEAQRQEVLQQLLHLQVREEGRSLQLLSQASFGNMS", "length": 293, "header": "tr|E1BCS6-1|E1BCS6_BOVIN Isoform 1 of Sterile alpha motif domain containing 10 OS=Bos taurus OX=9913 GN=SAMD10 PE=4 SV=4 CANONICAL=E1BCS6-1" }, "locus": { "chromosome": "13", "start_pos": 53876511, "end_pos": 53872848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015478.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015478.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015478.8", "url": "https://www.ensembl.org/id/ENSBTAP00000015478.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "E1BCS6", "url": "https://www.uniprot.org/uniprotkb/E1BCS6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "E1BCS6", "url": "https://www.uniprot.org/uniprotkb/E1BCS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCS6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 293, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCS6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCS6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCS6" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 275, "start_aa": "Trp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCU1-1", "uniprot_ac": "E1BCU1", "uniprot_id": "E1BCU1_BOVIN", "mass": { "chemical_mass": 122958.0, "monoisotopic_mass": 122958.0 }, "refseq": { "ac": "NP_001193161", "name": "ubiquitin-protein ligase E3B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193161" }, "gene_names": [ { "name": "UBE3B", "type": "recommended", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "name": "UBE3B", "type": "synonym", "evidence": [ { "id": "NP_001193161", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193161" } ] } ], "protein_names": [ { "name": "Ubiquitin-protein ligase E3B", "type": "recommended", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1/entry#names_and_taxonomy" } ] }, { "name": "HECT-type ubiquitin transferase E3B", "type": "synonym", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-protein ligase E3B", "type": "synonym", "evidence": [ { "id": "NP_001193161", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193161" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes. Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC.", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1#function" }, { "database": "UniProtKB", "id": "ARBA00056642", "url": "https://www.uniprot.org/uniprotkb/ARBA00056642#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE3B", "url": "https://www.uniprot.org/uniprotkb/E1BCU1", "locus": { "chromosome": "17", "start_pos": 63650234, "end_pos": 63695236, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002698", "url": "https://www.ensembl.org/id/ENSBTAG00000002698" } ] } } ], "crossref": [ { "id": "E1BCU1", "url": "https://alphafold.ebi.ac.uk/entry/E1BCU1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002698", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512750", "url": "https://www.ncbi.nlm.nih.gov/gene/512750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NTKCTAP", "url": "https://omabrowser.org/oma/group/NTKCTAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCU1", "url": "https://www.orthodb.org/?gene=E1BCU1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45700", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45700", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45700:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45700:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193161", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFTVSQTSRAWFIDRARQAREERLVQKERERAAVEIQAHIRSFLCRRRLQREIRREIDEFFKAEDSGSSKRSALCIFKIARKLLFLFRIKEDNERFEKLCRCILSSMEAENEPKVWYVSLALSKDLTLLWIKQIKDILWYCCEFLEQLKPEILQDSKLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGFYPVLQILLTRGLARPRPCLSKGTLTAAFSLAMRPVLAAQFSDNLIRPFLIHIVSVPALVTHLSTVTPERLTVLESHDMLRKFIAFLRDEDRCRDVCESLEGCHTLCLMGNLLQLGSLSPRVLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMPLITKQLQFLWGVPLIRVFFSDILSKKLLETQEPAHAPPASPQNVLPVKTLLKRAFQKSASVRNILRPVGGKRVDSTEAQKVCRVCVLYQTSLATLTQIRLQVLTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPSVLFQELDKDRKRAQLILQYIPHVIPHKNRVLLFRNMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1068, "header": "tr|E1BCU1-1|E1BCU1_BOVIN Isoform 1 of Ubiquitin-protein ligase E3B OS=Bos taurus OX=9913 GN=UBE3B PE=4 SV=1 CANONICAL=E1BCU1-1" }, "isoforms": [ { "isoform_ac": "E1BCU1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1/entry#E1BCU1-1", "sequence": { "sequence": "MFTVSQTSRAWFIDRARQAREERLVQKERERAAVEIQAHIRSFLCRRRLQREIRREIDEFFKAEDSGSSKRSALCIFKIARKLLFLFRIKEDNERFEKLCRCILSSMEAENEPKVWYVSLALSKDLTLLWIKQIKDILWYCCEFLEQLKPEILQDSKLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGFYPVLQILLTRGLARPRPCLSKGTLTAAFSLAMRPVLAAQFSDNLIRPFLIHIVSVPALVTHLSTVTPERLTVLESHDMLRKFIAFLRDEDRCRDVCESLEGCHTLCLMGNLLQLGSLSPRVLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMPLITKQLQFLWGVPLIRVFFSDILSKKLLETQEPAHAPPASPQNVLPVKTLLKRAFQKSASVRNILRPVGGKRVDSTEAQKVCRVCVLYQTSLATLTQIRLQVLTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPSVLFQELDKDRKRAQLILQYIPHVIPHKNRVLLFRNMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1068, "header": "tr|E1BCU1-1|E1BCU1_BOVIN Isoform 1 of Ubiquitin-protein ligase E3B OS=Bos taurus OX=9913 GN=UBE3B PE=4 SV=1 CANONICAL=E1BCU1-1" }, "locus": { "chromosome": "17", "start_pos": 63691303, "end_pos": 63652115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084286.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084286.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062126.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:512750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512750", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0E7-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "Ube3b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFTVSQTSRAWFLDKARQAREERLEQKERERSAVLIQALVRSFLCRRRLHKDVRREIDEFFTADESGSSKRSALCIFKIARKLLFICKTTEDNERMEKLCRSILSSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWYCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGFYSVLQVLLTRGLARPRPCLSKSTLTAAFTLALRPVVAAQFSDSLMRPFIIHIMSVPALVAHLSTMAPERLGVLESHDMLRKFIVFLRDRDRCQDACESLEGCHTLCLMGNLLHLGSLNLKMLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNDSMYLITKQLQFLWGVPLIRIFFSDILSKKLLEPPEPVPAQPQPSSPQTVLPVKSLLKRAFQKSASVRNILKPVGGRRVDSTEVRKVCSICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPGVLFQELDKDRKRAQLILLHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLPQHAMKGAIRVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDVADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIVWLWDILASDFTPGERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1070 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287BH46-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "UBE3B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFTVSQTSRAWFIDRARQAREERLVQKERERAAVDIQAHVRSFLCRRRLQREIRREIDEFLKADDSGSSKRSALCIFKIARKLLFLFRIKEDNERFEKLCRCILSSMEAENEPKVWYVSLALSKDLTLLWIKQIKDILWYCCEFLKQLKPEILQDSKLITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQVLLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLLRPFLIHIVSVPALVTHLSTVTPERLTVLESHDMLHKFITFLRDEDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMPLITKQLQFLWGVPLIRIFFNDILSKKLLENPEPAHVPPASSPQNVLPVKTLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPSVLFQELDKDRKRAQLILQYIPHVIPHKNRVLLFRNMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWTRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1069 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8N1YZY7-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "ube3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFTATQTSKTQFLDKARVAREERKGHKEKERAATQIQALVRRFLCRCRLQKEIRKEVDDFIAVSDAGPTKRNALSIFKIARKLLFILSKDDKLRFEKLCRIILNSMDVENEPKVWYVSLALSKDLTILWLKQIKDVLWVSCEFLKKLKPDILQDNKLVTLYLTMLITFTDTSTWKIIRGKGEALKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLSLRPVIAAHFSDNLLRSFLLHVMSVPAFISHLNTLTPDCMITIQTHDLFRKFVLFLSREEQCLDICVCLEGSHTLCLLGNLIQLGYFNVKVLEQEAGHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTKQLQCLWGVPVICTLFCDVLSKKLETQDPTPPPAPQPSSLQNNLPVKNLFKRAFQKSASVRNILKPVGGKRVDSAEVQKVCSICVLYQTALTTLTQIRLQILTGLTYLDELLPKLWAFICELGPQGGLRLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELVTISSFLNTFVYKMVWDGILENAKGEKLDLFHSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSLLFQELEKGKKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSSIHENHLQLFEFVGKMLGKAMYEGIVVDVPFASFFLSQVLGHHHSTFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVILWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFELS", "length": 1069 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZKK3-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "UBE3B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFSASQSSKAQFLDKARQAREERRELKERERAAVQIQALVRRFLCRCHLQKEIRREVEDFFGATESGASKRSALSVFRIARKLLFVFNHKEDKERFEKLCRCILNSMDVENEPKVWYVSLALSKDLTLLWIKQIKDILWFCCEFLKQLKPDILQDSRLVNLHLTMLVTFTDTSTWKILRGKGETLRPAMNHICANIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGSLTAIFSLALRPVVAAQFSDNLLRSFLIHIMSVPAIMTHLATLTPERLAVIESHDLLRKFIIFLSREAQCRDVCVCLEGSHTLCLLGNLVYLGSLNDKVLEDETAHFVGVLIHMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRILFSDVLSKKLLENQEIAQLPTQPVSPQNSLPMKNLFKRAFQKSASVRNILKPVGGKRVDSAEVQKVCSICVLYQTTLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLNNDTEESKRLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENARGETLELFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPSVLFQELDKDKKRAQLLLQYIPHVIPHKNRVLLFRNMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKTIPVTNENKISYIHLMAHFRMHTQIKSQTAALISGFRSIIKPEWIRMFSAPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILANDFSPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILREKLRYAISMNTGFELS", "length": 1070 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HI81-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "Ube3b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFTVSQTSRAWFIDRARQAREERLGQKERERSAVIIQALVRSFLCRRRLHRDIRIEIDEFFKRDDSGSSKRSALCIFKIARKLLFIYKTKEDHERLEKLCRSILSSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWYCCELLEQLKPEILQDSRLITLHLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGFYSVLQVLLTRGLARSRPCLSTGTLTATFSLALRPVVASQFSDNLMRPFVIHIMSVPALVTHLSTVAPERLSVLESHDMLRKFIVFLRDRDRCLDACESLEGCHTLCLMGNILHLGSLNPKVLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMYLITKQLQFLWGVPLIRIFFCDILSKKLLEHPEPAPAQPSSPQNVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVQKVCSICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIAENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPGVLFQELDRDRKRAQLILQHIPHVVPHKNRVLLFRNMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEMDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1068 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7Z3V4-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "UBE3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1068 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ES34-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "Ube3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARRLLFICKTTEDSERLEKLCRSILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS", "length": 1070 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VSS9-1", "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "NM_140022.1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFAQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHDDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS", "length": 1078 }, "evidence": [ { "id": "E1BCU1", "url": "https://omabrowser.org/oma/group/E1BCU1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "E1BCU1", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1044, "end_pos": 1046, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" }, { "start_pos": 829, "end_pos": 831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 894, "end_pos": 896, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCU1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1068, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCU1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCU1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 702, "end_pos": 1068, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1044, "end_pos": 1046 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 517, "end_pos": 519 }, { "start_pos": 829, "end_pos": 831 }, { "start_pos": 894, "end_pos": 896 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCU2-1", "uniprot_ac": "E1BCU2", "uniprot_id": "E1BCU2_BOVIN", "mass": { "chemical_mass": 162741.0, "monoisotopic_mass": 162741.0 }, "refseq": { "ac": "XP_024838415", "name": "myomesin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838415" }, "gene_names": [ { "name": "MYOM3", "type": "recommended", "evidence": [ { "id": "E1BCU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" } ] }, { "name": "MYOM3", "type": "synonym", "evidence": [ { "id": "XP_024838415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838415" } ] } ], "protein_names": [ { "name": "Myomesin-3", "type": "recommended", "evidence": [ { "id": "E1BCU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU2/entry#names_and_taxonomy" } ] }, { "name": "Myomesin family member 3", "type": "synonym", "evidence": [ { "id": "E1BCU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU2/entry#names_and_taxonomy" } ] }, { "name": "myomesin-3", "type": "synonym", "evidence": [ { "id": "XP_024838415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838415" } ] } ], "function": [ { "annotation": "May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.", "evidence": [ { "database": "UniProtKB", "id": "E1BCU2", "url": "https://www.uniprot.org/uniprotkb/E1BCU2#function" }, { "database": "UniProtKB", "id": "ARBA00053644", "url": "https://www.uniprot.org/uniprotkb/ARBA00053644#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCU2", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOM3", "url": "https://www.uniprot.org/uniprotkb/E1BCU2", "locus": { "chromosome": "2", "start_pos": 128840064, "end_pos": 128788282, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014885", "url": "https://www.ensembl.org/id/ENSBTAG00000014885" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014885", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014885", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532872", "url": "https://www.ncbi.nlm.nih.gov/gene/532872", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532872", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532872", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BCU2", "url": "https://www.orthodb.org/?gene=E1BCU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838415", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838415", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCU2", "url": "https://www.uniprot.org/uniprotkb/E1BCU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLPHSPGGVGEPRPPQAMQVHRREHRREEEQKEERQHSLQMDSSMRKRTFRSSEEEYQFSAADYALAAALALTASSETTWEAQLRRQTSTVELEERGQKRVGFGNDWERTEIAFLRTQWLLRQRRDRKALRRRTEEKVREAKELRELCSGRGPWFWIPLRSHAVWEHTTVLLTCTVQGSPPPQVTWYKNDVRIDPRLFPAGKYRITNNYGLLTLEIRRCTIEDAATYTVKVKNAYGQASSFAKVLVRTYLGKDAGFDSEMFKRLMFGPSVDFTSVLKPVFAREKETFSLKCLFSEDVLDAEQNIQWFRDGRLLRSSGRRQILYADRQAVLKVACAYKEDEGLYTVQVPSPFGLQEQSAYVFVRDAAAEKPGVPGSPLNVRCLNVNRDCLILTWTPPSDTRGNPITGYSIELCQGESEEWVPCHQAPGGTCRCPIQGLIEGQSYRFRVRAINRAGSSVPSKASEPVVMGDRDEAQRKTEIPFDMGKSITVSTDDFDDFVTIPSPPTNVHGSEIREAYVVLAWEEPRPRGKAPLTYFLEKSVIGSGTWEAVNSEAPVKSPRFALLDLEKGKSYVFRVRAINQYGMSDPSEPSEPIALRGKPATLPPPTQVQAFRDTQTSVSLTWDPVKDSPELLGYYIYSREAGSSEWRTVNNKPIQGSRFTIPGLRTGKEYEFCIRSVSEAGVGESSAVTEPIRVKQALATPSAPYDFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHEVNQQPVPTQICKVSNLHEGHFYEFRARAVNWAGVGELSAPSKLFECKEWTMPQPGPPYDLRVSEVRATSLMLAWEPPLYRGAGPVTGYRISVQEEGSEQWKPVTPDLISDTHLRISDLQPGKTYMFQVQAVNSAGPGQPSMPTDPVLLEDKPDAREIEVGVDDEGFIYMAFEAPEAPDSAEFQWSKDYKGPPDPERVKVEEEANKSKIILKDPGLEDLGTYSVVVTDADEDISASHTLTEDELNKLKKLSHEIRNPVIKLISGWNVEILEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFVREKGLVEVIIQHLTEDDKGSYTAQLQDGKAKNQITLALVDDEFDKLLRAADAKRRDWKRKQGPYFVEPLQWKVTDDCQVLLTCKVTNTKKETRFQWFFQKREFPAGQYDPQTGAGLLCIEELSKEDQGVYRAQVSDDRGEDDTILDLRDEALDAIFTELGRIGALSATPLKIQGTEEGIRLFSKVKYYNVKYMKTTWFHKEKRLESGDRVRAGTTLDEIWLHILDPKDSDKGKYILEITAGKEVRQLSADLSGQAFEDAMAEHQRLKALAIIEKNRAKVVRGLPDVATIMEDKTLCLTCVVSGDPAPEIYWLKNDQPVTFLDRYHMDVKGTEVTITIERVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGEEEKVLKM", "length": 1438, "header": "tr|E1BCU2-1|E1BCU2_BOVIN Isoform 1 of Myomesin-3 OS=Bos taurus OX=9913 GN=MYOM3 PE=4 SV=4 CANONICAL=E1BCU2-1" }, "isoforms": [ { "isoform_ac": "E1BCU2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU2/entry#E1BCU2-1", "sequence": { "sequence": "MTLPHSPGGVGEPRPPQAMQVHRREHRREEEQKEERQHSLQMDSSMRKRTFRSSEEEYQFSAADYALAAALALTASSETTWEAQLRRQTSTVELEERGQKRVGFGNDWERTEIAFLRTQWLLRQRRDRKALRRRTEEKVREAKELRELCSGRGPWFWIPLRSHAVWEHTTVLLTCTVQGSPPPQVTWYKNDVRIDPRLFPAGKYRITNNYGLLTLEIRRCTIEDAATYTVKVKNAYGQASSFAKVLVRTYLGKDAGFDSEMFKRLMFGPSVDFTSVLKPVFAREKETFSLKCLFSEDVLDAEQNIQWFRDGRLLRSSGRRQILYADRQAVLKVACAYKEDEGLYTVQVPSPFGLQEQSAYVFVRDAAAEKPGVPGSPLNVRCLNVNRDCLILTWTPPSDTRGNPITGYSIELCQGESEEWVPCHQAPGGTCRCPIQGLIEGQSYRFRVRAINRAGSSVPSKASEPVVMGDRDEAQRKTEIPFDMGKSITVSTDDFDDFVTIPSPPTNVHGSEIREAYVVLAWEEPRPRGKAPLTYFLEKSVIGSGTWEAVNSEAPVKSPRFALLDLEKGKSYVFRVRAINQYGMSDPSEPSEPIALRGKPATLPPPTQVQAFRDTQTSVSLTWDPVKDSPELLGYYIYSREAGSSEWRTVNNKPIQGSRFTIPGLRTGKEYEFCIRSVSEAGVGESSAVTEPIRVKQALATPSAPYDFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHEVNQQPVPTQICKVSNLHEGHFYEFRARAVNWAGVGELSAPSKLFECKEWTMPQPGPPYDLRVSEVRATSLMLAWEPPLYRGAGPVTGYRISVQEEGSEQWKPVTPDLISDTHLRISDLQPGKTYMFQVQAVNSAGPGQPSMPTDPVLLEDKPDAREIEVGVDDEGFIYMAFEAPEAPDSAEFQWSKDYKGPPDPERVKVEEEANKSKIILKDPGLEDLGTYSVVVTDADEDISASHTLTEDELNKLKKLSHEIRNPVIKLISGWNVEILEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFVREKGLVEVIIQHLTEDDKGSYTAQLQDGKAKNQITLALVDDEFDKLLRAADAKRRDWKRKQGPYFVEPLQWKVTDDCQVLLTCKVTNTKKETRFQWFFQKREFPAGQYDPQTGAGLLCIEELSKEDQGVYRAQVSDDRGEDDTILDLRDEALDAIFTELGRIGALSATPLKIQGTEEGIRLFSKVKYYNVKYMKTTWFHKEKRLESGDRVRAGTTLDEIWLHILDPKDSDKGKYILEITAGKEVRQLSADLSGQAFEDAMAEHQRLKALAIIEKNRAKVVRGLPDVATIMEDKTLCLTCVVSGDPAPEIYWLKNDQPVTFLDRYHMDVKGTEVTITIERVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGEEEKVLKM", "length": 1438, "header": "tr|E1BCU2-1|E1BCU2_BOVIN Isoform 1 of Myomesin-3 OS=Bos taurus OX=9913 GN=MYOM3 PE=4 SV=4 CANONICAL=E1BCU2-1" }, "locus": { "chromosome": "2", "start_pos": 128839060, "end_pos": 128790797, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019817.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019817.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019817.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019817.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 701, "start_aa": "Thr", "end_pos": 701, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr701", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532872", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532872", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "E1BCU2", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "E1BCU2", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 954, "end_pos": 956, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 376, "end_pos": 471, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 154, "end_pos": 246, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 701 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 954, "end_pos": 956 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCU4-1", "uniprot_ac": "E1BCU4", "uniprot_id": "E1BCU4_BOVIN", "mass": { "chemical_mass": 30023.0, "monoisotopic_mass": 30023.0 }, "refseq": {}, "gene_names": [ { "name": "PRSS33", "type": "recommended", "evidence": [ { "id": "E1BCU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ] } ], "protein_names": [ { "name": "tryptase", "type": "recommended", "evidence": [ { "id": "E1BCU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU4/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.59", "type": "synonym", "evidence": [ { "id": "E1BCU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.", "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4#function" }, { "database": "UniProtKB", "id": "ARBA00054350", "url": "https://www.uniprot.org/uniprotkb/ARBA00054350#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRSS33", "url": "https://www.uniprot.org/uniprotkb/E1BCU4", "locus": { "chromosome": "25", "start_pos": 2275167, "end_pos": 2271693, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034368", "url": "https://www.ensembl.org/id/ENSBTAG00000034368" } ] } } ], "crossref": [ { "id": "E1BCU4", "url": "https://alphafold.ebi.ac.uk/entry/E1BCU4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034368", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCU4", "url": "https://www.orthodb.org/?gene=E1BCU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKWASSLQVLLLLLLGAAGTLGYVACGQPRVSSRIVGGRDARAGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRKALPADYRVRLGAPHLGPSSPPALLAPVRRVLLPPDYSEDGAHGDLALLLLRRPTPLSTRVQPVCLPEPGARPPPGTPCWVTGWGSLRPGVPLPEWRPLQGVRVPLLDAHTCDHLYHLGTDVPRAEHIVLPGSLCAGYVGGQKDACQGDSGGPLVCMKSGRWILVGVVSWGKGCALPNRPGVYTNVATYSPWIQAHLNIPCSD", "length": 282, "header": "tr|E1BCU4-1|E1BCU4_BOVIN Isoform 1 of tryptase OS=Bos taurus OX=9913 GN=PRSS33 PE=4 SV=4 CANONICAL=E1BCU4-1" }, "isoforms": [ { "isoform_ac": "E1BCU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU4/entry#E1BCU4-1", "sequence": { "sequence": "MKWASSLQVLLLLLLGAAGTLGYVACGQPRVSSRIVGGRDARAGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRKALPADYRVRLGAPHLGPSSPPALLAPVRRVLLPPDYSEDGAHGDLALLLLRRPTPLSTRVQPVCLPEPGARPPPGTPCWVTGWGSLRPGVPLPEWRPLQGVRVPLLDAHTCDHLYHLGTDVPRAEHIVLPGSLCAGYVGGQKDACQGDSGGPLVCMKSGRWILVGVVSWGKGCALPNRPGVYTNVATYSPWIQAHLNIPCSD", "length": 282, "header": "tr|E1BCU4-1|E1BCU4_BOVIN Isoform 1 of tryptase OS=Bos taurus OX=9913 GN=PRSS33 PE=4 SV=4 CANONICAL=E1BCU4-1" }, "locus": { "chromosome": "25", "start_pos": 2274501, "end_pos": 2271693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027425.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027425.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027425.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027425.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BCU4", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCU4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 282, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCU4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCU4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU4" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 277, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.59", "ec_name": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.", "evidence": [ { "id": "3.4.21.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.59" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCV2-1", "uniprot_ac": "E1BCV2", "uniprot_id": "E1BCV2_BOVIN", "mass": { "chemical_mass": 111455.0, "monoisotopic_mass": 111455.0 }, "refseq": { "ac": "XP_002699101", "name": "DNA damage-induced apoptosis suppressor protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699101" }, "gene_names": [ { "name": "DDIAS", "type": "recommended", "evidence": [ { "id": "E1BCV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ] }, { "name": "DDIAS", "type": "synonym", "evidence": [ { "id": "XP_002699101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699101" } ] } ], "protein_names": [ { "name": "DNA damage-induced apoptosis suppressor protein", "type": "recommended", "evidence": [ { "id": "E1BCV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV2/entry#names_and_taxonomy" } ] }, { "name": "DNA damage-induced apoptosis suppressor protein", "type": "synonym", "evidence": [ { "id": "XP_002699101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699101" } ] }, { "name": "Nitric oxide-inducible gene protein", "type": "synonym", "evidence": [ { "id": "E1BCV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be an anti-apoptotic protein involved in DNA repair or cell survival.", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2#function" }, { "database": "UniProtKB", "id": "ARBA00053253", "url": "https://www.uniprot.org/uniprotkb/ARBA00053253#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDIAS", "url": "https://www.uniprot.org/uniprotkb/E1BCV2", "locus": { "chromosome": "29", "start_pos": 12722591, "end_pos": 12744742, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011636", "url": "https://www.ensembl.org/id/ENSBTAG00000011636" } ] } } ], "crossref": [ { "id": "E1BCV2", "url": "https://alphafold.ebi.ac.uk/entry/E1BCV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011636", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011636", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618360", "url": "https://www.ncbi.nlm.nih.gov/gene/618360", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043522", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043522", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618360", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618360", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BCV2", "url": "https://www.orthodb.org/?gene=E1BCV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35537:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35537:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002699101", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699101", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RRW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQWEHMNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGEAENAIYRYKLSLKVAESNKLFGVTVFGSCLDAFFGLTATGLHRYIQDPSEIPETLGSDTTQNLLTKAVETCFVGQNFVFGVTNFENQHGKGSGSSNFSEQCSDRKRVVKALVACQIIPPDPNVVGFTVIDYFRRLLKLSAVRKLRCGSQTPNSHLLALESSNSDLSSLCGPDSSSCFEPHDKDYFPGFWQLSLDLTSVVSQLTDDGFSALEQSKAIGTLHQNRKCISSAEATGSNSCLDTIQGSWSLVSHMDKKSSALKLDEEPGLQANQPSAVHSNHHEIGVPDSNLFPIKVQERFEPRNTKSFHSAVEVTYSQHEITCHQNQEVDTLPSFQQRCMCYPSSSLRLEEIVSGSQDCDLEIWDDLPLSESLNKFLAAIESEIAVNQTDASSRKCRLDNDISKLHVDHSRLSLTPQRTPGALHTPRIALRSPPATVKANSSRENFLSNHEANPSPSIHKESQPENRAEALSFSGNKRDISEHSLPNVHLSALFPSSKGSGTTVALKSTRILPCETEISCKHNTSEADHSCLSSKYNNGCGEKSLSEMSEKLTTLHSRRYNVVSKFPSLENKQYCRRPKNQGNSLTICRKLTYPLEALHSTPNRSMNILREMLYEHTGNNPTQNCSTGHEGSYNASVDLFDDSPKEMDIVTEMTKRSQNIFLQWGKSLAESHHTESDFSLRSLSENSSQSSQKLSLQNTSASLYPRTCPSPPHFQSDSEYDIEYSQDFVPCSQSTPVTGFHQSRIHGMKGAFQKLPAFYLDLDANYKKTRISSANDALQATPVCPKNIKTPGQKSRSPTVSGTPPEVSNNHPVTECLETDADEWVPPTTQKVFPSDMLGFWATGLRKCHAAYNSPDQNELPRKKLKYGKQRTGKCLIKKELNLKTMLTAAVIKQKTPDYNNIRSGWISKESVLGRGSCAEVKCCLPFSENWSPSAPESKSAWSPELFSQNVT", "length": 1004, "header": "tr|E1BCV2-1|E1BCV2_BOVIN Isoform 1 of DNA damage-induced apoptosis suppressor protein OS=Bos taurus OX=9913 GN=DDIAS PE=4 SV=3 CANONICAL=E1BCV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV2/entry#A0AAA9RRW9-1", "sequence": { "sequence": "MPQWEHMNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGEAENAIYRYKLSLKVAESNKLFGVTVFGSCLDAFFGLTATGLHRILKTSMEKVQVPVTSQSSAQTARELKHS", "length": 126, "header": "tr|A0AAA9RRW9-1|A0AAA9RRW9_BOVIN Computationally mapped isoform of DNA damage induced apoptosis suppressor OS=Bos taurus OX=9913 GN=DDIAS PE=4 SV=1 CANONICAL=E1BCV2-1" }, "locus": { "chromosome": "29", "start_pos": 12736826, "end_pos": 12726108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119976.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119976.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075017.1" } ] } }, { "isoform_ac": "E1BCV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV2/entry#E1BCV2-1", "sequence": { "sequence": "MPQWEHMNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGEAENAIYRYKLSLKVAESNKLFGVTVFGSCLDAFFGLTATGLHRYIQDPSEIPETLGSDTTQNLLTKAVETCFVGQNFVFGVTNFENQHGKGSGSSNFSEQCSDRKRVVKALVACQIIPPDPNVVGFTVIDYFRRLLKLSAVRKLRCGSQTPNSHLLALESSNSDLSSLCGPDSSSCFEPHDKDYFPGFWQLSLDLTSVVSQLTDDGFSALEQSKAIGTLHQNRKCISSAEATGSNSCLDTIQGSWSLVSHMDKKSSALKLDEEPGLQANQPSAVHSNHHEIGVPDSNLFPIKVQERFEPRNTKSFHSAVEVTYSQHEITCHQNQEVDTLPSFQQRCMCYPSSSLRLEEIVSGSQDCDLEIWDDLPLSESLNKFLAAIESEIAVNQTDASSRKCRLDNDISKLHVDHSRLSLTPQRTPGALHTPRIALRSPPATVKANSSRENFLSNHEANPSPSIHKESQPENRAEALSFSGNKRDISEHSLPNVHLSALFPSSKGSGTTVALKSTRILPCETEISCKHNTSEADHSCLSSKYNNGCGEKSLSEMSEKLTTLHSRRYNVVSKFPSLENKQYCRRPKNQGNSLTICRKLTYPLEALHSTPNRSMNILREMLYEHTGNNPTQNCSTGHEGSYNASVDLFDDSPKEMDIVTEMTKRSQNIFLQWGKSLAESHHTESDFSLRSLSENSSQSSQKLSLQNTSASLYPRTCPSPPHFQSDSEYDIEYSQDFVPCSQSTPVTGFHQSRIHGMKGAFQKLPAFYLDLDANYKKTRISSANDALQATPVCPKNIKTPGQKSRSPTVSGTPPEVSNNHPVTECLETDADEWVPPTTQKVFPSDMLGFWATGLRKCHAAYNSPDQNELPRKKLKYGKQRTGKCLIKKELNLKTMLTAAVIKQKTPDYNNIRSGWISKESVLGRGSCAEVKCCLPFSENWSPSAPESKSAWSPELFSQNVT", "length": 1004, "header": "tr|E1BCV2-1|E1BCV2_BOVIN Isoform 1 of DNA damage-induced apoptosis suppressor protein OS=Bos taurus OX=9913 GN=DDIAS PE=4 SV=3 CANONICAL=E1BCV2-1" }, "locus": { "chromosome": "29", "start_pos": 12736826, "end_pos": 12723595, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015454.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015454.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015454.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015454.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618360", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618360", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:1902230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902230", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" }, { "name": "regulation of DNA stability", "id": "GO:0097752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "E1BCV2", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1002, "end_pos": 1004, "annotation": "n_glycosylation_sequon" }, { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 750, "end_pos": 752, "annotation": "n_glycosylation_sequon" }, { "start_pos": 982, "end_pos": 984, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1004, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCV2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV2" }, { "id": "PF08646", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08646" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Replication factor A C-terminal", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 101, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1002, "end_pos": 1004 }, { "start_pos": 151, "end_pos": 153 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 492, "end_pos": 494 }, { "start_pos": 575, "end_pos": 577 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 686, "end_pos": 688 }, { "start_pos": 738, "end_pos": 740 }, { "start_pos": 750, "end_pos": 752 }, { "start_pos": 982, "end_pos": 984 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCV6-1", "uniprot_ac": "E1BCV6", "uniprot_id": "E1BCV6_BOVIN", "mass": { "chemical_mass": 53211.0, "monoisotopic_mass": 53211.0 }, "refseq": {}, "gene_names": [ { "name": "RANBP3L", "type": "recommended", "evidence": [ { "id": "E1BCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ] } ], "protein_names": [ { "name": "Ran-binding protein 3-like", "type": "recommended", "evidence": [ { "id": "E1BCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6#function" }, { "database": "UniProtKB", "id": "ARBA00059866", "url": "https://www.uniprot.org/uniprotkb/ARBA00059866#function" }, { "database": "UniProtKB", "id": "A0AAA9TQZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ9#function" }, { "database": "UniProtKB", "id": "G3MX58", "url": "https://www.uniprot.org/uniprotkb/G3MX58#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RANBP3L", "url": "https://www.uniprot.org/uniprotkb/E1BCV6", "locus": { "chromosome": "20", "start_pos": 37991946, "end_pos": 37937166, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008430", "url": "https://www.ensembl.org/id/ENSBTAG00000008430" } ] } } ], "crossref": [ { "id": "E1BCV6", "url": "https://alphafold.ebi.ac.uk/entry/E1BCV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008430", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008430", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13180", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13180", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296398", "url": "https://www.ncbi.nlm.nih.gov/gene/100296398", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296398", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296398", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BCV6", "url": "https://www.orthodb.org/?gene=E1BCV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MX58", "url": "https://www.orthodb.org/?gene=G3MX58", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23138", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23138", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23138:SF88", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23138:SF88", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00638", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00638", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TQZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCV6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX58", "url": "https://www.uniprot.org/uniprotkb/G3MX58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX58-1", "url": "https://www.uniprot.org/uniprotkb/G3MX58-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTMQRKGSSHLFNSVHTCRLKLPQEQQHQEKSVIAQPIFVFEKREQTFKRPADDILYEAAERECNEFSRKRVRASSFTWHTTDSQNQGVKKNNVFMTSNSVQRNADLNSAEQCPVKHSELVLRPAILQPPQAQGYIKVRKSFGDHVLESCKVKEKNKSKIYEGNSYLLSENLPNARISIQLSTNQNALGTTSLRCQPSEDKYSMKSCSSDFVFGENMVERVLGTQKLTQPQLESDLYIKEKPFKFTLKIPVNSPNSRTDTIENISLIESAAAFSFKPSPKCLLEKIDIITGEEAEHNVLEINCKLFRFNKTTQSWTERGRGALRLNDTARSDCGTFQSRLIMRNQGSLRLILNSKLWAQMEIQRANHKNLQITATDLEDCNVKVFLIQASAKDTGRMHAAIHHRLVALRSFDKRTDANQTESQSETVLQQCNYDSCDEDEEDLIQATKARSDSYRWTHRQSVACS", "length": 466, "header": "tr|E1BCV6-1|E1BCV6_BOVIN Isoform 1 of Ran-binding protein 3-like OS=Bos taurus OX=9913 GN=RANBP3L PE=4 SV=3 CANONICAL=E1BCV6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TQZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV6/entry#A0AAA9TQZ9-1", "sequence": { "sequence": "MQRKGSSHLFNSVHTCRLKLPQEQQHQEKSVIAQPIFVFEKREQTFKRPADDILYEAAERECNEFSRKRVRASSFTWHTTDSQNQGGPVKHSELVLRPAILQPPQAQGYIKVRKSFGDHVLESCKVKEKNKSKIYEGNSYLLSENLPNARISIQLSTNQNALGTTSLRCQPSEDKYSMKSCSSDFVFGENMVERVLGTQKLTQPQLESDLYIKEKPFKFTLKIPVNSPNSRTDTIENISLIESAAAFSFKPSPKCLLEKIDIITGEEAEHNVLEINCKLFRFNKTTQSWTERGRGALRLNDTARSDCGTFQSRLIMRNQGSLRLILNSKLWAQMEIQRANHKNLQITATDLEDCNVKVFLIQASAKDTGRMHAAIHHRLVALRSFDKRTDANQTESQSETVLQQCNYDSCDEDEEDLIQATKARSGKG", "length": 428, "header": "tr|A0AAA9TQZ9-1|A0AAA9TQZ9_BOVIN Computationally mapped isoform of Ran-binding protein 3-like OS=Bos taurus OX=9913 GN=RANBP3L PE=4 SV=2 CANONICAL=E1BCV6-1" }, "locus": { "chromosome": "20", "start_pos": 37990736, "end_pos": 37937374, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093692.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093692.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101011.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101011.2" } ] } }, { "isoform_ac": "E1BCV6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV6/entry#E1BCV6-1", "sequence": { "sequence": "MSTMQRKGSSHLFNSVHTCRLKLPQEQQHQEKSVIAQPIFVFEKREQTFKRPADDILYEAAERECNEFSRKRVRASSFTWHTTDSQNQGVKKNNVFMTSNSVQRNADLNSAEQCPVKHSELVLRPAILQPPQAQGYIKVRKSFGDHVLESCKVKEKNKSKIYEGNSYLLSENLPNARISIQLSTNQNALGTTSLRCQPSEDKYSMKSCSSDFVFGENMVERVLGTQKLTQPQLESDLYIKEKPFKFTLKIPVNSPNSRTDTIENISLIESAAAFSFKPSPKCLLEKIDIITGEEAEHNVLEINCKLFRFNKTTQSWTERGRGALRLNDTARSDCGTFQSRLIMRNQGSLRLILNSKLWAQMEIQRANHKNLQITATDLEDCNVKVFLIQASAKDTGRMHAAIHHRLVALRSFDKRTDANQTESQSETVLQQCNYDSCDEDEEDLIQATKARSDSYRWTHRQSVACS", "length": 466, "header": "tr|E1BCV6-1|E1BCV6_BOVIN Isoform 1 of Ran-binding protein 3-like OS=Bos taurus OX=9913 GN=RANBP3L PE=4 SV=3 CANONICAL=E1BCV6-1" }, "locus": { "chromosome": "20", "start_pos": 37991122, "end_pos": 37937365, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011090.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011090.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011090.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011090.7" } ] } }, { "isoform_ac": "G3MX58-1", "url": "https://www.uniprot.org/uniprotkb/E1BCV6/entry#G3MX58-1", "sequence": { "sequence": "MQRKGSSHLFNSVHTCRLKLPQEQQHQEKSVIAQPIFVFEKREQTFKRPADDILYEAAERECNEFSRKRVRASSFTWHTTDSQNQGGPVKHSELVLRPAILQPPQAQGYIKVRKSFGDHVLESCKVKEKNKSKIYEGNSYLLSENLPNARISIQLSTNQNALGTTSLRCQPSEDKYSMKSCSSDFVFGENMVERVLGTQKLTQPQLESDLYIKEKPFKFTLKIPVNSPNSRTDTIENISLIESAAAFSFKPSPKCLLEKIDIITGEEAEHNVLEINCKLFRFNKTTQSWTERGRGALRLNDTARSDCGTFQSRLIMRNQGSLRLILNSKLWAQMEIQRANHKNLQITATDLEDCNVKVFLIQASAKDTGRMHAAIHHRLVALRSFDKRTDANQTESQSETVLQQCNYDSCDEDEEDLIQATKARSDSYRWTHRQSVACS", "length": 439, "header": "tr|G3MX58-1|G3MX58_BOVIN Computationally mapped isoform of Ran-binding protein 3-like OS=Bos taurus OX=9913 GN=RANBP3L PE=4 SV=2 CANONICAL=E1BCV6-1" }, "locus": { "chromosome": "20", "start_pos": 37991122, "end_pos": 37937374, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065667.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065667.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054118.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054118.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296398", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296398", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mesenchymal cell differentiation involved in bone development", "id": "GO:1901706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901706", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" }, { "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" }, { "name": "protein export from nucleus", "id": "GO:0006611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006611", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" }, { "name": "positive regulation of myoblast differentiation", "id": "GO:0045663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045663", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SMAD binding", "id": "GO:0046332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "evidence": [ { "database": "UniProtKB", "id": "E1BCV6", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 466, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCV6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCV6" }, { "id": "PS50196", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50196" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RanBD1", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 364, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 310, "end_pos": 312 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 419, "end_pos": 421 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCW5-1", "uniprot_ac": "E1BCW5", "uniprot_id": "E1BCW5_BOVIN", "mass": { "chemical_mass": 184485.0, "monoisotopic_mass": 184485.0 }, "refseq": { "ac": "XP_024838113", "name": "ADAMTS-like protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838113" }, "gene_names": [ { "name": "ADAMTSL3", "type": "recommended", "evidence": [ { "id": "E1BCW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" } ] }, { "name": "ADAMTSL3", "type": "synonym", "evidence": [ { "id": "XP_024838113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838113" } ] } ], "protein_names": [ { "name": "ADAMTS like 3", "type": "synonym", "evidence": [ { "id": "E1BCW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW5/entry#names_and_taxonomy" } ] }, { "name": "ADAMTS-like protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838113" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCW5", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAMTSL3", "url": "https://www.uniprot.org/uniprotkb/E1BCW5", "locus": { "chromosome": "21", "start_pos": 24112342, "end_pos": 24493322, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004645", "url": "https://www.ensembl.org/id/ENSBTAG00000004645" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004645", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004645", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537483", "url": "https://www.ncbi.nlm.nih.gov/gene/537483", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838113", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838113", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCW5", "url": "https://www.uniprot.org/uniprotkb/E1BCW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCW5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRKSPWWLLMWLVFMHSALLQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEEKDSNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGRYYEWLPQYNDPAAPCALRCQARGQNLVVELAPKVLDGTRCTADSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGATCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFVVENTTVEFQKGSERQTFKIPGPLMADFIFKTRYTVAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRTFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGQHVGGCNPQLKLHIKEECIIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFVPEPWSACSATCGPGVQVREVKCRVLLTFTQTETELPEEECEGPRLPTERPCLLQPCDESPAVRELAASLQEQDSETTYDWEYAGFTPCTATCLGGHQEAIAVCLHLQTQQTVNDTLCDMVHRPPAMSQACNTEPCPPRWHMGSWGPCSATCGVGIQTREVYCLHPGESPSPPEECRDEKPHALQACNQFDCPPSWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSEELCQGPKASSRKSCARTDCPPHWTVGDWSKCSVSCGVGTQRRQQMCQKLTAKGRRVPLSETLCRHLSGPPLVRSCQMPVCGKMKPEMKARVREQGPQILGVQRVYIQTREEKRINLTVGSRAYLLPNTSVIIKCPVRRFQKSRIQWEKDGRCLQNSKRLGFTKSGSLKIHSLAALDIGEYRCIAGPAQETVVLKLIGTDNRLIAPPALGGHTREYPGMDNNEANNLGATWHKMRLMWNNKNELYLHNGQINNQSLLRALLGHCSPSAGNANSWEFENKQFEAAVKQGAYSMETAQFDELIRNMSQLMETGEISDDLASQVIYQLVAELTKVQPAHAHWRGIPGEAPPTAQLRGETGSVPQSSNSKNSGKLTFKPKGPVLLRQSQPTLISFNKTVNSRIGNTVYITRRTEVINILCELVSPSEATYTWTKDGALLQPSEKVILDGMGKMQIRKPTKKDQGIYGCAVANHLGSDVESSSVLYAEAPVILSVGRNITRPERGHLSIVIGSFVEAPLQANVTIQCPVKGVPQPNVTWLKKGGSLSDNISLLFNGSLLLQNLSLENEGTYVCTATNALGKAMATSVLHLLETFWELGNWTHCSATCGHLGAQVQRPQCLMANGQEVSEAFCDQLRKPQAAFQPCNIQDCPPRWLTGAWSECSVSCGEGFRSRQVTCKRTRANGTVQALPPRVCILRDRPLGRRPCSSHPCVQGLFEQGNQCPGRCLGRIVRMQQHHIICQHPNSSESGCDDTKRPIVQKNCLLGACDACWRAGPWKPCTTACGRGFQSRKVDCVHPGSCKPVTKTRCAPGKKPASWQHCLGPSCDRDCTDTTHYCTFVKHLHLCSLDRYKRRCCQSCQEG", "length": 1656, "header": "tr|E1BCW5-1|E1BCW5_BOVIN Isoform 1 of ADAMTS like 3 OS=Bos taurus OX=9913 GN=ADAMTSL3 PE=4 SV=4 CANONICAL=E1BCW5-1" }, "isoforms": [ { "isoform_ac": "E1BCW5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCW5/entry#E1BCW5-1", "sequence": { "sequence": "MASRKSPWWLLMWLVFMHSALLQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEEKDSNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGRYYEWLPQYNDPAAPCALRCQARGQNLVVELAPKVLDGTRCTADSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGATCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFVVENTTVEFQKGSERQTFKIPGPLMADFIFKTRYTVAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRTFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGQHVGGCNPQLKLHIKEECIIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFVPEPWSACSATCGPGVQVREVKCRVLLTFTQTETELPEEECEGPRLPTERPCLLQPCDESPAVRELAASLQEQDSETTYDWEYAGFTPCTATCLGGHQEAIAVCLHLQTQQTVNDTLCDMVHRPPAMSQACNTEPCPPRWHMGSWGPCSATCGVGIQTREVYCLHPGESPSPPEECRDEKPHALQACNQFDCPPSWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSEELCQGPKASSRKSCARTDCPPHWTVGDWSKCSVSCGVGTQRRQQMCQKLTAKGRRVPLSETLCRHLSGPPLVRSCQMPVCGKMKPEMKARVREQGPQILGVQRVYIQTREEKRINLTVGSRAYLLPNTSVIIKCPVRRFQKSRIQWEKDGRCLQNSKRLGFTKSGSLKIHSLAALDIGEYRCIAGPAQETVVLKLIGTDNRLIAPPALGGHTREYPGMDNNEANNLGATWHKMRLMWNNKNELYLHNGQINNQSLLRALLGHCSPSAGNANSWEFENKQFEAAVKQGAYSMETAQFDELIRNMSQLMETGEISDDLASQVIYQLVAELTKVQPAHAHWRGIPGEAPPTAQLRGETGSVPQSSNSKNSGKLTFKPKGPVLLRQSQPTLISFNKTVNSRIGNTVYITRRTEVINILCELVSPSEATYTWTKDGALLQPSEKVILDGMGKMQIRKPTKKDQGIYGCAVANHLGSDVESSSVLYAEAPVILSVGRNITRPERGHLSIVIGSFVEAPLQANVTIQCPVKGVPQPNVTWLKKGGSLSDNISLLFNGSLLLQNLSLENEGTYVCTATNALGKAMATSVLHLLETFWELGNWTHCSATCGHLGAQVQRPQCLMANGQEVSEAFCDQLRKPQAAFQPCNIQDCPPRWLTGAWSECSVSCGEGFRSRQVTCKRTRANGTVQALPPRVCILRDRPLGRRPCSSHPCVQGLFEQGNQCPGRCLGRIVRMQQHHIICQHPNSSESGCDDTKRPIVQKNCLLGACDACWRAGPWKPCTTACGRGFQSRKVDCVHPGSCKPVTKTRCAPGKKPASWQHCLGPSCDRDCTDTTHYCTFVKHLHLCSLDRYKRRCCQSCQEG", "length": 1656, "header": "tr|E1BCW5-1|E1BCW5_BOVIN Isoform 1 of ADAMTS like 3 OS=Bos taurus OX=9913 GN=ADAMTSL3 PE=4 SV=4 CANONICAL=E1BCW5-1" }, "locus": { "chromosome": "21", "start_pos": 24491526, "end_pos": 24113346, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006101.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006101.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006101.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006101.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "E1BCW5", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BCW5", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1053, "end_pos": 1055, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1103, "end_pos": 1105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1192, "end_pos": 1194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1293, "end_pos": 1295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1317, "end_pos": 1319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1331, "end_pos": 1333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1344, "end_pos": 1346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1350, "end_pos": 1352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1357, "end_pos": 1359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1394, "end_pos": 1396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1478, "end_pos": 1480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1539, "end_pos": 1541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" }, { "start_pos": 798, "end_pos": 800, "annotation": "n_glycosylation_sequon" }, { "start_pos": 916, "end_pos": 918, "annotation": "n_glycosylation_sequon" }, { "start_pos": 928, "end_pos": 930, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 897, "end_pos": 993, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW5" }, { "id": "PS50900", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50900" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PLAC", "eco_id": "ECO_0000259", "start_pos": 1620, "end_pos": 1656, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1053, "end_pos": 1055 }, { "start_pos": 1103, "end_pos": 1105 }, { "start_pos": 1192, "end_pos": 1194 }, { "start_pos": 1293, "end_pos": 1295 }, { "start_pos": 1317, "end_pos": 1319 }, { "start_pos": 1331, "end_pos": 1333 }, { "start_pos": 1344, "end_pos": 1346 }, { "start_pos": 1350, "end_pos": 1352 }, { "start_pos": 1357, "end_pos": 1359 }, { "start_pos": 1394, "end_pos": 1396 }, { "start_pos": 1478, "end_pos": 1480 }, { "start_pos": 1539, "end_pos": 1541 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 682, "end_pos": 684 }, { "start_pos": 798, "end_pos": 800 }, { "start_pos": 916, "end_pos": 918 }, { "start_pos": 928, "end_pos": 930 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCX1-1", "uniprot_ac": "E1BCX1", "uniprot_id": "E1BCX1_BOVIN", "mass": { "chemical_mass": 35929.0, "monoisotopic_mass": 35929.0 }, "refseq": { "ac": "NP_001377531", "name": "olfactory receptor family 5 subfamily F member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531" }, "gene_names": [ { "name": "OR5F2", "type": "recommended", "evidence": [ { "id": "E1BCX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ] }, { "name": "OR5F2", "type": "synonym", "evidence": [ { "id": "NP_001377531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 5 subfamily F member 2", "type": "synonym", "evidence": [ { "id": "E1BCX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX1/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 5F1", "type": "synonym", "evidence": [ { "id": "NP_001377531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531" } ] }, { "name": "olfactory receptor family 5 subfamily F member 2", "type": "synonym", "evidence": [ { "id": "NP_001377531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5F2", "url": "https://www.uniprot.org/uniprotkb/E1BCX1", "locus": { "chromosome": "15", "start_pos": 78694818, "end_pos": 78695774, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058716", "url": "https://www.ensembl.org/id/ENSBTAG00000058716" } ] } } ], "crossref": [ { "id": "E1BCX1", "url": "https://alphafold.ebi.ac.uk/entry/E1BCX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053492", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053492", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15411", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15411", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788874", "url": "https://www.ncbi.nlm.nih.gov/gene/788874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788874", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788874", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMSRTIC", "url": "https://omabrowser.org/oma/group/IMSRTIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCX1", "url": "https://www.orthodb.org/?gene=E1BCX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377531", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARKNYTSLTEFILLGLADTLELRVILFCLFSMIYMLTVVGNVGMILLIRMDSRLHTPMYFFLANLSFVDVCYSSTITPKMLVDLLSEKKTISFAGCFLQMYFFIAFATIECILFGLMAHDRYVAICNPLLYSLIMSRTVCLKMAAGAFTAGLLNSVVHTGYVSSLSFCSSNVIHHFFCDSPPIFKLSCSDTHLYESILSTFAGVNMVGALLVILTSYCYILFSIFHMHSREGRRKAFSTCVSHLTAIILFYSTSIYTYLRPTSSYSLNQDKVASVFYTVVIPMLNPLIYSLRNKEVKRALWNAITRKMVPLFLGLLP", "length": 318, "header": "tr|E1BCX1-1|E1BCX1_BOVIN Isoform 1 of Olfactory receptor family 5 subfamily F member 2 OS=Bos taurus OX=9913 GN=OR5F2 PE=3 SV=3 CANONICAL=E1BCX1-1" }, "isoforms": [ { "isoform_ac": "E1BCX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1/entry#E1BCX1-1", "sequence": { "sequence": "MARKNYTSLTEFILLGLADTLELRVILFCLFSMIYMLTVVGNVGMILLIRMDSRLHTPMYFFLANLSFVDVCYSSTITPKMLVDLLSEKKTISFAGCFLQMYFFIAFATIECILFGLMAHDRYVAICNPLLYSLIMSRTVCLKMAAGAFTAGLLNSVVHTGYVSSLSFCSSNVIHHFFCDSPPIFKLSCSDTHLYESILSTFAGVNMVGALLVILTSYCYILFSIFHMHSREGRRKAFSTCVSHLTAIILFYSTSIYTYLRPTSSYSLNQDKVASVFYTVVIPMLNPLIYSLRNKEVKRALWNAITRKMVPLFLGLLP", "length": 318, "header": "tr|E1BCX1-1|E1BCX1_BOVIN Isoform 1 of Olfactory receptor family 5 subfamily F member 2 OS=Bos taurus OX=9913 GN=OR5F2 PE=3 SV=3 CANONICAL=E1BCX1-1" }, "locus": { "chromosome": "15", "start_pos": 78695774, "end_pos": 78694821, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032086.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032086.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032028.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032028.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788874", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788874", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCX1", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 318, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCX1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCX4-1", "uniprot_ac": "E1BCX4", "uniprot_id": "E1BCX4_BOVIN", "mass": { "chemical_mass": 83183.0, "monoisotopic_mass": 83183.0 }, "refseq": { "ac": "XP_002685089", "name": "tripartite motif-containing protein 42 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685089" }, "gene_names": [ { "name": "TRIM42", "type": "recommended", "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" } ] }, { "name": "TRIM42", "type": "synonym", "evidence": [ { "id": "XP_002685089", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685089" } ] } ], "protein_names": [ { "name": "Tripartite motif containing 42", "type": "synonym", "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4/entry#names_and_taxonomy" } ] }, { "name": "tripartite motif-containing protein 42 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002685089", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685089" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCX4", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM42", "url": "https://www.uniprot.org/uniprotkb/E1BCX4", "locus": { "chromosome": "1", "start_pos": 128258678, "end_pos": 128288461, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018346", "url": "https://www.ensembl.org/id/ENSBTAG00000018346" } ] } } ], "crossref": [ { "id": "E1BCX4", "url": "https://alphafold.ebi.ac.uk/entry/E1BCX4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018346", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018346", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19782", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19782", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520038", "url": "https://www.ncbi.nlm.nih.gov/gene/520038", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520038", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520038", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGNQQIY", "url": "https://omabrowser.org/oma/group/FGNQQIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCX4", "url": "https://www.orthodb.org/?gene=E1BCX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685089", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685089", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCX4", "url": "https://www.uniprot.org/uniprotkb/E1BCX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCX4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTAMCVCSPCCTWQRCCPRLCSCLCCKFLFTSERNCTCFPCPYKDERNCQFCHCTCSENPNCHWCCCSWANDPNCKCCCTASSNLKCYYYESRCCRNATITFRKGRLRSIRTSSKTALRIGSSDTQLEEVKMMPTANSNLVSHLSCPICGRLRLHSFMLPCHHSLCEKCLRRLQKHAEVTENFFILICPVCNRSHCMSYSHKMQLPENYLRGRLTKRYMQQHGYLKWRFDRSSGPIVCQVCRSQRIAYKRCLTCRLNLCNECLKTFHSDVAMQDHVFVDTSTEDQDEKICIHHPSSRIIEYCRNDNELLCGFCKTSLHNGHDTISLIDACSERAAALFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEVKRKEIRNGFLKLRSILQEKEKTIMEQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEDGIQSTYRPDPQLRLHSLNCMPLDFAELSSAIHELFPTGPKKVCSSGDSLPSPYPLQSEMMIARKVTFSTHSFNNQQIYQRSSSLLSFNAPACEKTKIGLEAYGRAQSAAPAKPTDGLYTYWSAGVENQPVQNSNSFHNWYSFNDSSVQTPGPIIIYQTLVYPRAAKVYWTCPTEDVDSFEMEFYELITSPPNNVRTELCGQIRDIMQQNLELHNLTPNTEYLFKVRAINDNGPGQWSDICKVVTPDGRGKNRAKWGLLKNIQTALQKRF", "length": 725, "header": "tr|E1BCX4-1|E1BCX4_BOVIN Isoform 1 of Tripartite motif containing 42 OS=Bos taurus OX=9913 GN=TRIM42 PE=4 SV=1 CANONICAL=E1BCX4-1" }, "isoforms": [ { "isoform_ac": "E1BCX4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX4/entry#E1BCX4-1", "sequence": { "sequence": "MDTAMCVCSPCCTWQRCCPRLCSCLCCKFLFTSERNCTCFPCPYKDERNCQFCHCTCSENPNCHWCCCSWANDPNCKCCCTASSNLKCYYYESRCCRNATITFRKGRLRSIRTSSKTALRIGSSDTQLEEVKMMPTANSNLVSHLSCPICGRLRLHSFMLPCHHSLCEKCLRRLQKHAEVTENFFILICPVCNRSHCMSYSHKMQLPENYLRGRLTKRYMQQHGYLKWRFDRSSGPIVCQVCRSQRIAYKRCLTCRLNLCNECLKTFHSDVAMQDHVFVDTSTEDQDEKICIHHPSSRIIEYCRNDNELLCGFCKTSLHNGHDTISLIDACSERAAALFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEVKRKEIRNGFLKLRSILQEKEKTIMEQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEDGIQSTYRPDPQLRLHSLNCMPLDFAELSSAIHELFPTGPKKVCSSGDSLPSPYPLQSEMMIARKVTFSTHSFNNQQIYQRSSSLLSFNAPACEKTKIGLEAYGRAQSAAPAKPTDGLYTYWSAGVENQPVQNSNSFHNWYSFNDSSVQTPGPIIIYQTLVYPRAAKVYWTCPTEDVDSFEMEFYELITSPPNNVRTELCGQIRDIMQQNLELHNLTPNTEYLFKVRAINDNGPGQWSDICKVVTPDGRGKNRAKWGLLKNIQTALQKRF", "length": 725, "header": "tr|E1BCX4-1|E1BCX4_BOVIN Isoform 1 of Tripartite motif containing 42 OS=Bos taurus OX=9913 GN=TRIM42 PE=4 SV=1 CANONICAL=E1BCX4-1" }, "locus": { "chromosome": "1", "start_pos": 128288461, "end_pos": 128258681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024411.4", "url": "https://www.ensembl.org/id/ENSBTAT00000024411.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024411.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024411.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520038", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520038", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HSW0-1", "protein_name": "Tripartite motif-containing protein 42", "gene_name": "Trim42", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MESAMCVCSPCCTWQRCCPRLFSCLCCKFIFTAERNCTCFPCPYKDERNCQFCHCTCAENPNCHWCCCSWANDPNCKCCCTSNTNMKCYYYESRCCHNAIITFRRGRLRTLRISSKTALRIGSSETQLEELKSMTPSNNLVSHLTCPMCNRLRLHSFMLPCNHSLCEKCLRQLQKHAEVTENFFILICPMCNRSHCMPYSHQTHLPENYLRGRLTKRYMQQHGYLKWRFDRSSGPILCQVCRTRRIAYKRCITCRLNLCNECLKAFHSDVAMQDHVFVDTSAEDQDEKICIHHPSSRINEYCRSDNQLLCAFCKIAFHNGHDTVSLIDACSERSAALFSAIAKFKAVRYEIDNDLMEFNILKSSFKADKEAKRKEIRSGFLKLRAILQEKEKLIMEQIENLEVSRQKEIEKYVNITTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEEGIQNTFRPDPQLRLHSLQCIPLDFAELSSAIHELFPTGPKKACSSGDSLPSQYPIHSEMMIARKVTFSTHSFGNQQIYQRSSSLLSFSATNDKAKMEAFGRAQSTAPVRPTDGLYTYWSATGETQPPQNSNSFHNWYSFNDTSVKTPGPIVIYQTLVYPRAAKVYWTCPTEDVDSFEMEFYELINTPPNNVRTELCGQIRDIMQQNLELHNLTPNTEYLFKVRAINDNGPGQWSDICKVVTPDGRGKNRAKWGLLKNIQSALQKRF", "length": 721 }, "evidence": [ { "id": "E1BCX4", "url": "https://omabrowser.org/oma/group/E1BCX4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8IWZ5-1", "protein_name": "Tripartite motif-containing protein 42", "gene_name": "TRIM42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METAMCVCCPCCTWQRCCPQLCSCLCCKFIFTSERNCTCFPCPYKDERNCQFCHCTCSESPNCHWCCCSWANDPNCKCCCTASSNLNCYYYESRCCRNTIITFHKGRLRSIHTSSKTALRTGSSDTQVDEVKSIPANSHLVNHLNCPMCSRLRLHSFMLPCNHSLCEKCLRQLQKHAEVTENFFILICPVCDRSHCMPYSNKMQLPENYLHGRLTKRYMQEHGYLKWRFDRSSGPILCQVCRNKRIAYKRCITCRLNLCNDCLKAFHSDVAMQDHVFVDTSAEEQDEKICIHHPSSRIIEYCRNDNKLLCTFCKFSFHNGHDTISLIDACSERAASLFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEAKRKEIRNGFLKLRSILQEKEKIIMEQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEDGIQTTYRPDPQLRLHSINYVPLDFVELSSAIHELFPTGPKKVRSSGDSLPSPYPVHSETMIARKVTFSTHSLGNQHIYQRSSSMLSFSNTDKKAKVGLEACGRAQSATPAKPTDGLYTYWSAGADSQSVQNSSSFHNWYSFNDGSVKTPGPIVIYQTLVYPRAAKVYWTCPAEDVDSFEMEFYEVITSPPNNVQMELCGQIRDIMQQNLELHNLTPNTEYVFKVRAINDNGPGQWSDICKVVTPDGHGKNRAKWGLLKNIQSALQKHF", "length": 723 }, "evidence": [ { "id": "E1BCX4", "url": "https://omabrowser.org/oma/group/E1BCX4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2H5-1", "protein_name": "Tripartite motif-containing protein 42", "gene_name": "Trim42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METAMCVCSPCCTWQRCCPRLFSCLCCKFIFTSERNCTCFPCPYKDERNCQFCHCTCAENPNCHWCCCSWANDPNCKCCCTASTNLKCYYYESHCCRNVTITFRKGRLRSIVTSSKTALRVGSSDTQMDEPKTMPASSHLVSHLTCPMCNRLRLHSFMLPCNHSLCEKCLRQLQKHAEVTENFFILICPMCSRSHCMPYSHQMHLPENYLRGRLTKRYMQQHGYLKWRFDRSSGPILCQVCRTRRIAYKRCVTCRLNLCNDCLKAFHSDVAMQDHVFVDTSAEDQDEKICIHHPSSRINEYCRSDNQLLCAFCKIAFHNGHDTVSLIDACSERSAALFSAIAKFKAVRYEIDNDLMEFNILKSSFKADKEAKRKEVRNGFLKLRAILQEKEKIIMEQIENLEVSRQKEIEKYVYITTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEEGIQNTFRPDPQLRLHSLHCIPLDFAELSNAIHELFPTGPKKACSSGDSLPSQYPIHSEMMIARKVTFSTHSFGNQQIYQRSSSLISFNTANDKGKMGLENYGRAQSAAPAKTTDGLYTYWSATGETQPPQSSNSFHNWYSFNDTSVRTPGPIVIYQTLVYPRAAKVYWTCPTEDVDSFEMEFYELVTTPPNNVRTELCGQIRDILQQNLELHNLTPNTEYLFKVRAINDNGPGQWSDICKVVTPDGRGKNRAKWGLLKNIQSALQKRF", "length": 723 }, "evidence": [ { "id": "E1BCX4", "url": "https://omabrowser.org/oma/group/E1BCX4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCX4", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 599, "end_pos": 601, "annotation": "n_glycosylation_sequon" }, { "start_pos": 670, "end_pos": 672, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCX4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 725, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCX4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCX4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 286, "end_pos": 327, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" }, { "id": "PS51262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COS", "eco_id": "ECO_0000259", "start_pos": 435, "end_pos": 493, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 605, "end_pos": 703, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX4" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 193, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 599, "end_pos": 601 }, { "start_pos": 670, "end_pos": 672 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCX6-1", "uniprot_ac": "E1BCX6", "uniprot_id": "E1BCX6_BOVIN", "mass": { "chemical_mass": 79963.0, "monoisotopic_mass": 79963.0 }, "refseq": { "ac": "NP_001192821", "name": "transmembrane protease serine 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192821" }, "gene_names": [ { "name": "TMPRSS7", "type": "recommended", "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ] }, { "name": "TMPRSS7", "type": "synonym", "evidence": [ { "id": "NP_001192821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192821" } ] } ], "protein_names": [ { "name": "Transmembrane protease serine 7", "type": "recommended", "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6/entry#names_and_taxonomy" } ] }, { "name": "Matriptase-3", "type": "synonym", "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protease serine 7", "type": "synonym", "evidence": [ { "id": "NP_001192821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192821" } ] }, { "name": "transmembrane protease, serine 7", "type": "synonym", "evidence": [ { "id": "NP_001192821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192821" } ] } ], "function": [ { "annotation": "Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6#function" }, { "database": "UniProtKB", "id": "ARBA00057398", "url": "https://www.uniprot.org/uniprotkb/ARBA00057398#function" }, { "database": "UniProtKB", "id": "A0AAA9RZF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMPRSS7", "url": "https://www.uniprot.org/uniprotkb/E1BCX6", "locus": { "chromosome": "1", "start_pos": 56872261, "end_pos": 56822116, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015065", "url": "https://www.ensembl.org/id/ENSBTAG00000015065" } ] } } ], "crossref": [ { "id": "E1BCX6", "url": "https://alphafold.ebi.ac.uk/entry/E1BCX6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522055", "url": "https://www.ncbi.nlm.nih.gov/gene/522055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522055", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522055", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVFIFRR", "url": "https://omabrowser.org/oma/group/WVFIFRR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCX6", "url": "https://www.orthodb.org/?gene=E1BCX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192821", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCX6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRITNIEFLPEYRQKESREFLSVARTVQQVINLVYTTSAFSKFYKQSVVADVSNNKGGLLVHFWLVFVMPHAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDKGCSQDFYADHLSLRYPLEISTTSGRLMCHFKLVATVGHLIRLSIESVQIEADNCVTDSLTIYDSLLPIRSTILYRICEPARTLKSFVSTNNLMLVTFKSPQVWRLSGIWAYFEVIPEQKCENTVLVKEITGFEGKISSPYYPSYCPPKCKCTWKFQSPLSTLGIALKFHNYSITKKSMKGCDHGWWEINDHTYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPCPVGSFRCSSGVCVPQAQRCDGVNDCFDESDELFCVTLKPACNASSFGQQSPLICDGFQDCEDGQDEQNCTRSIPCNDRTFKCGNDVCIRKQNAKCDGNVDCPDGTDEEGCRCSSSSPTLHRIIGGTDTQEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGSRLSDPTPWTAHLGMNVQGNAKFISPVRRIVVHEYYNSQTFDYDIALLQLSVAWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADNKGSPILQQAEVELIDQTLCVSTYGIITSRMLCAGVMSGKKDACRGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 717, "header": "tr|E1BCX6-1|E1BCX6_BOVIN Isoform 1 of Transmembrane protease serine 7 OS=Bos taurus OX=9913 GN=TMPRSS7 PE=4 SV=2 CANONICAL=E1BCX6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZF0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX6/entry#A0AAA9RZF0-1", "sequence": { "sequence": "MDKENSHISSKPVDVNISNISVQVVNTPGKLPGRRPPRKPIARAKPKKQLKKKAPFWNVQNKIILFTVFLFILAVIAWTLLWLYIGKTESRDAFYFAGMFRITNIEFLPEYRQKESREFLSVARTVQQVINLVYTTSAFSKFYKQSVVADVSSNNKGGLLVHFWLVFVMPHAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNAGLRSDYSSTIGSNKGCSQDFYADHLSLRYPLEISTTSGRLMCHFKLVATVGHLIRLSIESVQIEADNCVTDSLTIYDSLLPIRSTILYRICEPARTLKSFVSTNNLMLVTFKSPQVWRLSGIWAYFEVIPEQKCENTVLVKEITGFEGKISSPYYPSYCPPKCKCTWKFQSPLSTLGIALKFHNYSITKKSMKGCDHGWWEINDHTYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPCPVGSFRCSSGVCVPQAQRCDGVNDCFDESDELFCVTLKPACNASSFGQQSPLICDGFQDCEDGQDEQNCTRSIPCNDRTFKCGNDVCIRKQNAKCDGNVDCPDGTDEEGCRCSSSSPTLHRIIGGTDTQEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGSRLSDPTPWTAHLGMNVQGNAKFISPVRRIVVHEYYNSQTFDYDIALLQLSVAWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADNKGSPILQQAEVELIDQTLCVSTYGIITSRMLCAGVMSGKKDACRGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 829, "header": "tr|A0AAA9RZF0-1|A0AAA9RZF0_BOVIN Computationally mapped isoform of Transmembrane protease serine 7 OS=Bos taurus OX=9913 GN=TMPRSS7 PE=4 SV=1 CANONICAL=E1BCX6-1" }, "locus": { "chromosome": "1", "start_pos": 56872159, "end_pos": 56822116, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097254.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097254.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075172.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075172.1" } ] } }, { "isoform_ac": "E1BCX6-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX6/entry#E1BCX6-1", "sequence": { "sequence": "MFRITNIEFLPEYRQKESREFLSVARTVQQVINLVYTTSAFSKFYKQSVVADVSNNKGGLLVHFWLVFVMPHAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDKGCSQDFYADHLSLRYPLEISTTSGRLMCHFKLVATVGHLIRLSIESVQIEADNCVTDSLTIYDSLLPIRSTILYRICEPARTLKSFVSTNNLMLVTFKSPQVWRLSGIWAYFEVIPEQKCENTVLVKEITGFEGKISSPYYPSYCPPKCKCTWKFQSPLSTLGIALKFHNYSITKKSMKGCDHGWWEINDHTYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPCPVGSFRCSSGVCVPQAQRCDGVNDCFDESDELFCVTLKPACNASSFGQQSPLICDGFQDCEDGQDEQNCTRSIPCNDRTFKCGNDVCIRKQNAKCDGNVDCPDGTDEEGCRCSSSSPTLHRIIGGTDTQEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGSRLSDPTPWTAHLGMNVQGNAKFISPVRRIVVHEYYNSQTFDYDIALLQLSVAWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADNKGSPILQQAEVELIDQTLCVSTYGIITSRMLCAGVMSGKKDACRGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 717, "header": "tr|E1BCX6-1|E1BCX6_BOVIN Isoform 1 of Transmembrane protease serine 7 OS=Bos taurus OX=9913 GN=TMPRSS7 PE=4 SV=2 CANONICAL=E1BCX6-1" }, "locus": { "chromosome": "1", "start_pos": 56872159, "end_pos": 56831560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020053.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020053.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020053.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020053.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522055", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522055", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QNS7-1", "protein_name": "Transmembrane protease serine 7", "gene_name": "TMPRSS7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDKENSDVSSKPADVNISNISVQVVSAQGKLAGRRPPRKLVSKAKPKKPPKKKVPFWNVQNKIILLTVFLFILAVVAWTLLWLYISKTESRDAFYFVGMFRVTNIEFLPEYRQKESREFLSVARTVQQVVNLVYTTSAFSKFYKQSVVADVSSNNKGGLLVHFWLVFVMPHAKGHVFCEDCVAAILKDSIQTSIVNRTSVGSLQGLAVDMDSVVLNAGLRSDYSSTIGSDKGCSQYFYADHLSLRYPLEISTTSGRLMCHFKLVAVVGHLIRLSIESVQIEADNCVTDSLTIYDSLLPIRSTILYRICEPTRTLMSFVSTNNLMLVTFKSPQVRRLSGIRAYFEVIPEQKCENTLLVKEITGFEGKISSPYYPSYYPPKCKCTWKFQTPLPTLGIALKFHNYSITKKSVKGCDHGWWEINEHMYCGSYVDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVTLKPACNVSSFRQQGPLVCDGFRDCEDGQDEQNCTQSIPCNHRTSKCGNDICIRKQNAGCDGAVDCPDGSDEEGCSCSRSSSTLHRIIGGTDTQEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRKHEADNKGSPVLQQAEVELIDQTVCVSTYGIITSRMLCAGVMSGKKDACRGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 829 }, "evidence": [ { "id": "E1BCX6", "url": "https://omabrowser.org/oma/group/E1BCX6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XK34-1", "protein_name": "Transmembrane serine protease 7", "gene_name": "TMPRSS7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDERIDHPAAKPEDDLSVANISVQMVSAEDKLVKRILARKKHGKLKKKEKMLWNFQNQIILFTLILFVLGVVTWTLLWLFIVQAENKDALYFVGLFRVANIEFLPEYRQKESKEFLSVAQNVQRVMNLVYTTSSFSKFYKQSTVTEVSNNNNGGLLIHFWIVFVVPQAKGQALCEDCVAAILKDSIQTSIVNRTSVGTLQDLAVDMDSIVLSAGLRSDYWSTTGTGSNCVYDLHADRLHEHFPLDIHTTSGGTICYLKLIALVGHLIRLSVVSLQIEADNCITDSLTIYDSLMPIKHKTLYRACEPADSLVSLVSTNNLMLVIFKAAHIKEQKGFHGYFEVITQERCGKAIVTKERIGYEGRITSPYYPSYYPPKCLCVWNFQTPQKNLGIALKFHNYTISEKNIKGCERGWWKINEHMYCGFYVDHQTVFHVASSAVNIELQCSSKVSEKPLLVEYGSYNISQPCPPGYFKCSTGLCIQQMQRCDGVNNCFDESDELFCVVPEWNCNSSFAIQDNLLVCNGVNDCENGEDEQNCTESIPCTNHTFKCRNNVCIKKQNAKCDGTVDCTDGSDESSCRCGSSKNGNLISRIVGGTNSKEGEWPWQVSLHFVGAAYCGASVISKEWLVSAAHCFQGSKLADPRAWRAHLGMRIQGRAKFVSAVRRIIVHEYYNSRNYDYDIALLQLSKPWPDTMSHVIQPICVPPFSHKVRSGDKCWITGWGQKQEADDEGAAILQKAEVEIIDQTLCHSTYGIITARMFCAGLMSGRRDGCKGDSGGPLSCQSNEDGKWFLTGIVSWGYGCGRPNFPGVYTRVSNLAPWIYKHVPSVM", "length": 827 }, "evidence": [ { "id": "E1BCX6", "url": "https://omabrowser.org/oma/group/E1BCX6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P86091-1", "protein_name": "Transmembrane protease serine 7", "gene_name": "Tmprss7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDKEKSDPSCKSSDLKISNISIQVVSVPGKLPGRRLPRKPIGKARPRKQPKKRAPFWNVQNKIILFTVFLFILAVTAWTLLWLYISKTDSKDAFYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVSSNNKGGLLVHFWIVFVMPHAKGHIFCEECVAAILKDSIQTSITNRTSVGTLQGLAVDMDSVVLNAGLRSDYSSAVGSDNGCSQYFYADHLTLRYPLEISATSGQLMCHFKLVAIVGYLIRLSIESIQLEADNCITDSLTVYDSLLPIRITCVLLSGYRICEPTRTLMSFVSTNNLMLVTLKSPYVRRLAGIRAYFEVIPEQKCENTILVKEINSFEGKISSPYYPSYYPPKCKCNWTFQTSLSTLGIALKFHNYSITKKSMKGCEHGWWEINEHMYCGSYMDHETIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVTAKPACNTSIFRQHGPLVCDGFQDCEDGQDEQNCTRSIPCTNRTFKCGNDICFRKQNAQCDGIVDCPDRSDEEGCGCSRSSPFLHRVVGGSDSQEGTWPWQVSLHFVGSAHCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLRQLIQPICIPPVGQRVRSGEKCWVTGWGRRHEADSKGSPILQQAEVELIDQTVCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLSCRRKSDGKWILTGIVSWGYGCGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 833 }, "evidence": [ { "id": "E1BCX6", "url": "https://omabrowser.org/oma/group/E1BCX6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7RTY8-1", "protein_name": "Transmembrane protease serine 7", "gene_name": "TMPRSS7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDKENSDVSAAPADLKISNISVQVVSAQKKLPVRRPPLPGRRLPLPGRRPPQRPIGKAKPKKQSKKKVPFWNVQNKIILFTVFLFILAVIAWTLLWLYISKTESKDAFYFAGMFRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSSNNKGGLLVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNAGLRSDYSSTIGSDKGCSQYFYAEHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQIEADNCVTDSLTIYDSLLPIRSSILYRICEPTRTLMSFVSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCENTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL", "length": 843 }, "evidence": [ { "id": "E1BCX6", "url": "https://omabrowser.org/oma/group/E1BCX6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BIK6-1", "protein_name": "Transmembrane protease serine 7", "gene_name": "Tmprss7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDKEKSDPSCKSSDLKISNISIQVVSVPGKLPGRRPPRKPIGKPRPRKQPKKRAPFWNVQNKIILFTVFLFILAVTAWTLLWLYISKTESKDAFYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVSSNNKGGLLVHFWIVFVMPHAKGHIFCEECVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNAGLRSDYSSAVGSDNGCSRYLYADHLTLRYPLEISATSGQLMCHFKLVAIVGYLIRLSIESIQLEADNCITDSLTVYDSLLPIRSAILYRICEPTRTLMSFVSTNNLMLVILKSPYVRRLAGIRAYFEVIPEQKCESTILVKEINSFEGKISSPYYPSYYPPKCKCTWTFQTSLSTLGIALKFYNYSITKKSAKGCEHGWWEINEHMYCGSYMDHETIFRVPSPLVHIQLQCSSRLSDKPLLVEYGGYNISQPCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVTVKPACNSSSFRQHGPLVCDGFRDCEDGQDEQNCTRSIPCTSRTFKCGNDICFRKQNAQCDGIVDCPDGSDEEGCGCSRSSSFLHRIVGGSDSQEGTWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFISPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQTVCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHKYVPSLL", "length": 829 }, "evidence": [ { "id": "E1BCX6", "url": "https://omabrowser.org/oma/group/E1BCX6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BCX6", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCX6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 717, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCX6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCX6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 121, "end_pos": 234, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 480, "end_pos": 714, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX6" }, { "id": "PS50024", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEA", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 121, "start_aa": "Met", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 289, "end_pos": 291 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCX7-1", "uniprot_ac": "E1BCX7", "uniprot_id": "E1BCX7_BOVIN", "mass": { "chemical_mass": 60139.0, "monoisotopic_mass": 60139.0 }, "refseq": {}, "gene_names": [ { "name": "LOC527385", "type": "recommended", "evidence": [ { "id": "E1BCX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ] } ], "protein_names": [ { "name": "Cationic amino acid transporter C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BCX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC527385", "url": "https://www.uniprot.org/uniprotkb/E1BCX7", "locus": {} } ], "crossref": [ { "id": "E1BCX7", "url": "https://alphafold.ebi.ac.uk/entry/E1BCX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040392", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040392", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCX7", "url": "https://www.orthodb.org/?gene=E1BCX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCX7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TLDLVVLGVASTLGAGVYILVGEVAMFIAGPAIVISFLVAALSSVLSGLCYAEFGTRVSWTGSAHLYSYISVGELWAFVTGWNLILAYVIAVASVAKAWSHTFDSLIGNHISQALEGIFSPYMPYFLATYPDFVALAMLLLLTGLLVLGAPESTLLYRVFTGINVLVLSFVIISGFVKGDLHNWKLTEQDYTLNTSESIGTSRLGPLGSGGFVPFGFDGILQGAAMCFYMFIGFDAIVTKGEEALNPQRSIPVSTMITIFICFLVCFGVSAALTLMVPYYQIHPENPLPEAFLLVGWGPARYVVAVGTLCALTSSLLGDMFPMPQVIYVMAEDGLLFRGLAQIHAHTGTPVMAIMSSGNLAAVMALLFKFSDLVDLLSIGTLLAYSLVALSVLALRYQPDQKFSKEKTEEEIEMKLKVEENISELVSEAGNSNILKSLWFPTSTIPTRKSGQIVYGCAFLLVLLLIILSLILAQWPSQLFSGDPVLTTVAVLLLLLIIGVTIIIWRQRQSPSPLPFRVPALPVLPLVSIFLNVYLMMQMTSGAWIQFSVWNSSLS", "length": 555, "header": "tr|E1BCX7-1|E1BCX7_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC527385 PE=3 SV=3 CANONICAL=E1BCX7-1" }, "isoforms": [ { "isoform_ac": "E1BCX7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCX7/entry#E1BCX7-1", "sequence": { "sequence": "TLDLVVLGVASTLGAGVYILVGEVAMFIAGPAIVISFLVAALSSVLSGLCYAEFGTRVSWTGSAHLYSYISVGELWAFVTGWNLILAYVIAVASVAKAWSHTFDSLIGNHISQALEGIFSPYMPYFLATYPDFVALAMLLLLTGLLVLGAPESTLLYRVFTGINVLVLSFVIISGFVKGDLHNWKLTEQDYTLNTSESIGTSRLGPLGSGGFVPFGFDGILQGAAMCFYMFIGFDAIVTKGEEALNPQRSIPVSTMITIFICFLVCFGVSAALTLMVPYYQIHPENPLPEAFLLVGWGPARYVVAVGTLCALTSSLLGDMFPMPQVIYVMAEDGLLFRGLAQIHAHTGTPVMAIMSSGNLAAVMALLFKFSDLVDLLSIGTLLAYSLVALSVLALRYQPDQKFSKEKTEEEIEMKLKVEENISELVSEAGNSNILKSLWFPTSTIPTRKSGQIVYGCAFLLVLLLIILSLILAQWPSQLFSGDPVLTTVAVLLLLLIIGVTIIIWRQRQSPSPLPFRVPALPVLPLVSIFLNVYLMMQMTSGAWIQFSVWNSSLS", "length": 555, "header": "tr|E1BCX7-1|E1BCX7_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC527385 PE=3 SV=3 CANONICAL=E1BCX7-1" }, "locus": { "chromosome": "18", "start_pos": 61187275, "end_pos": 61180951, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020051.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020051.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020051.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020051.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "E1BCX7", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 555, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCX7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCX7" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 516, "end_pos": 551, "start_aa": "Phe", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 551, "end_pos": 553 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCZ1-1", "uniprot_ac": "E1BCZ1", "uniprot_id": "E1BCZ1_BOVIN", "mass": { "chemical_mass": 65136.0, "monoisotopic_mass": 65136.0 }, "refseq": { "ac": "XP_024833542", "name": "BICD family-like cargo adapter 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833542" }, "gene_names": [ { "name": "BICDL1", "type": "recommended", "evidence": [ { "id": "E1BCZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1" } ] }, { "name": "BICDL1", "type": "synonym", "evidence": [ { "id": "XP_024833542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833542" } ] } ], "protein_names": [ { "name": "BICD family like cargo adaptor 1", "type": "synonym", "evidence": [ { "id": "E1BCZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1/entry#names_and_taxonomy" } ] }, { "name": "BICD family-like cargo adapter 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024833542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833542" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCZ1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BICDL1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1", "locus": { "chromosome": "17", "start_pos": 62471992, "end_pos": 62391862, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003696", "url": "https://www.ensembl.org/id/ENSBTAG00000003696" } ] } } ], "crossref": [ { "id": "E1BCZ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BCZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003696", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003696", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536747", "url": "https://www.ncbi.nlm.nih.gov/gene/536747", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536747", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536747", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PRQFGQY", "url": "https://omabrowser.org/oma/group/PRQFGQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR32123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32123:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32123:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833542", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833542", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TU83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAFCLGLAGRASAPAEPDSACCMELPAAAADAVGNPATATAAALISFPAGRGELELALEEELALLAAGERPSEPGEHPQAEPGPPAEAAGLQPPPAQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQVHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQVKVEELTEERSLQSSAATSASLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGSDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDSHLKERSRPPATLARAPGLGRGDEPSTAEGKRLFSFFRKI", "length": 576, "header": "tr|E1BCZ1-1|E1BCZ1_BOVIN Isoform 1 of BICD family like cargo adaptor 1 OS=Bos taurus OX=9913 GN=BICDL1 PE=4 SV=3 CANONICAL=E1BCZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TU83-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1/entry#A0AAA9TU83-1", "sequence": { "sequence": "MSAFCLGLAGRASAPAEPDSACCMELPAAAADAVGNPATATAAALISFPAGRGELELALEEELALLAAGERPSEPGEHPQAEPGPPAEAAGLQPPPAQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQVHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQVKVEELTEERSLQSSAATSASLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGSDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTSARRIDDDSLEEQIRQTSEDSRALRELMEGERGKLRQSLEELQRLHSQVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDSHLKERSRPPATLARAPGLGRGDEPSTAEGKRLFSFFRKI", "length": 624, "header": "tr|A0AAA9TU83-1|A0AAA9TU83_BOVIN Computationally mapped isoform of BICD family like cargo adaptor 1 OS=Bos taurus OX=9913 GN=BICDL1 PE=4 SV=1 CANONICAL=E1BCZ1-1" }, "locus": { "chromosome": "17", "start_pos": 62470988, "end_pos": 62392061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100894.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100894.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100115.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100115.1" } ] } }, { "isoform_ac": "E1BCZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1/entry#E1BCZ1-1", "sequence": { "sequence": "MSAFCLGLAGRASAPAEPDSACCMELPAAAADAVGNPATATAAALISFPAGRGELELALEEELALLAAGERPSEPGEHPQAEPGPPAEAAGLQPPPAQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQVHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQVKVEELTEERSLQSSAATSASLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGSDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDSHLKERSRPPATLARAPGLGRGDEPSTAEGKRLFSFFRKI", "length": 576, "header": "tr|E1BCZ1-1|E1BCZ1_BOVIN Isoform 1 of BICD family like cargo adaptor 1 OS=Bos taurus OX=9913 GN=BICDL1 PE=4 SV=3 CANONICAL=E1BCZ1-1" }, "locus": { "chromosome": "17", "start_pos": 62470988, "end_pos": 62392061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004815.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004815.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004815.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004815.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536747", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536747", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M3T2-1", "protein_name": "BICD family like cargo adaptor 1", "gene_name": "Bicdl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPAAAAALVSFPGGPGELELALEEELALLAAGERPSDLGEHPQAEPGSPAEGHGPPPPPTQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQLQDELERQQVHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTGTRRMDDESLEEQVRQTSEDSRALRELMEGERGKLRQSLEELQQLHSQVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKKAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQKHVTCPGTEVLGQPRQAWKQDSLSSQLTWAIWSRLMLGPEVSSAAPNPARCSASDNSDKWRDR", "length": 632 }, "evidence": [ { "id": "E1BCZ1", "url": "https://omabrowser.org/oma/group/E1BCZ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0JNT9-1", "protein_name": "BICD family-like cargo adapter 1", "gene_name": "Bicdl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPATAAALVSFPGGPGELELALEEELALLAAGERSSEPGEHPQAEPESPVEGHGPPLPPPPTQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQLQDELERQQLHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKEQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI", "length": 577 }, "evidence": [ { "id": "E1BCZ1", "url": "https://omabrowser.org/oma/group/E1BCZ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZP65-1", "protein_name": "BICD family-like cargo adapter 1", "gene_name": "BICDL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAFCLGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCRGHSAGRGDEPSIAEGKRLFSFFRKI", "length": 573 }, "evidence": [ { "id": "E1BCZ1", "url": "https://omabrowser.org/oma/group/E1BCZ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8SWR2-1", "protein_name": "Bicaudal D-related protein homolog", "gene_name": "BicDR", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHKPKLANAITAAAIASSISTKNNNNNSIVGGSSSSSSGGNKSKRPRQFGQYSIGVGTGAGAGGLLRSDDSGFDHLDYSSLIGDSIDLEHYISAMEARRHDQEPDVWAQLQQKESDILLAAELGKALLEKNEELVKQQEKLIEDYSSKIEKLEQEKHVLRQKLAIAEDESDQRVLELQSDLTELKDKLQTQDTAIRQAEKEKTILIDELQHQNTRLTEQIQEAHATELKLSAQIQELKDQYHYRNSSLQEHVNSLESIKTELNLTTGKRQELERRLQIAQEEKESLTSSLEESSDRIHMLERHAREQETKLETTLQALERSQRENNVLSERLGADTNSSTPGRKSLQFEMECDEDDGSYTETGKPNQMFVEARSVYIQLKSLVDSLKVSHDDDSGLNSDISLELESMDNTISSSERHEDGHLAIEFRQGMLSSMSDELTRLLLNLDAGNFKKMLDQTRNLVLEQEDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARGDLEDNTDRDELLSKAQTERDAANDRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLEQWQMDMHELIDEQMRSKLINNRRAMAAESSAPSPPSSAAANLAKRVTSYKLWSLFQR", "length": 620 }, "evidence": [ { "id": "E1BCZ1", "url": "https://omabrowser.org/oma/group/E1BCZ1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vesicle transport along microtubule", "id": "GO:0047496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047496", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1" } ], "pmid": "" }, { "name": "Golgi to secretory granule transport", "id": "GO:0055107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055107", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 576, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCZ1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 514, "end_pos": 516 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD08-1", "uniprot_ac": "E1BD08", "uniprot_id": "E1BD08_BOVIN", "mass": { "chemical_mass": 67716.0, "monoisotopic_mass": 67716.0 }, "refseq": { "ac": "NP_001192471", "name": "ENTH domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192471" }, "gene_names": [ { "name": "ENTHD1", "type": "recommended", "evidence": [ { "id": "E1BD08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ] }, { "name": "ENTHD1", "type": "synonym", "evidence": [ { "id": "NP_001192471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192471" } ] } ], "protein_names": [ { "name": "ENTH domain containing 1", "type": "synonym", "evidence": [ { "id": "E1BD08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD08/entry#names_and_taxonomy" } ] }, { "name": "ENTH domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001192471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192471" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ENTHD1", "url": "https://www.uniprot.org/uniprotkb/E1BD08", "locus": { "chromosome": "5", "start_pos": 111158863, "end_pos": 111255976, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000326", "url": "https://www.ensembl.org/id/ENSBTAG00000000326" } ] } } ], "crossref": [ { "id": "E1BD08", "url": "https://alphafold.ebi.ac.uk/entry/E1BD08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000326", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000326", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16990", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538470", "url": "https://www.ncbi.nlm.nih.gov/gene/538470", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538470", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538470", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMNMLWH", "url": "https://omabrowser.org/oma/group/IMNMLWH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD08", "url": "https://www.orthodb.org/?gene=E1BD08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12276", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12276:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192471", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD08-1", "url": "https://www.uniprot.org/uniprotkb/E1BD08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFRRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWQRLNDHGKNWRHVYKSLTLMDYLIKNGSKKVIQHCREGYCNLQTLKDFQHIDEAGKDQGYYIREKSKQVITLLMDEQLLHREREVACRTRRRTSYSMTFPKRLPGAGNSPTACASAPTPEIPVSEKKNKLLKIARLHNKKNTSKAGQKQEQCQDMEVPSGTVLSQETPIKINAWKSTEDLMLFCEDDPKPVLPIIPTSIVSSMARLSEGQTDVYNLWDTDAVPVPSEKTPSLQTNVSLVKNLDSTITKTVTGNPLQMPLEKQPAAKSCDTLTTLQAHWPSSQEEFIGPHLRTSKSDSTFRNQASVETLYVSPSFTTFDPMKETVISKGHQKATRSGLVPMEDENLKTLATWVSAASEGTFSFSTLSVSSPDSASPVKSVHPLPPVLAGPSFWTLSRQQSSSASVKNIDKTARIHHPFAPRSPLSSDEKENEHLNLLEILPDNSGSAEEKTSSISSSNWVAFSTQNVDHFTSMSCSSSQATKDLSREPEADSSTNVLLGEVKNAIVTLHEDLSMVIRELNVISSRLVSMSGSSPQISKSLQFPQYSEAGSDQV", "length": 610, "header": "tr|E1BD08-1|E1BD08_BOVIN Isoform 1 of ENTH domain containing 1 OS=Bos taurus OX=9913 GN=ENTHD1 PE=4 SV=1 CANONICAL=E1BD08-1" }, "isoforms": [ { "isoform_ac": "E1BD08-1", "url": "https://www.uniprot.org/uniprotkb/E1BD08/entry#E1BD08-1", "sequence": { "sequence": "MAFRRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWQRLNDHGKNWRHVYKSLTLMDYLIKNGSKKVIQHCREGYCNLQTLKDFQHIDEAGKDQGYYIREKSKQVITLLMDEQLLHREREVACRTRRRTSYSMTFPKRLPGAGNSPTACASAPTPEIPVSEKKNKLLKIARLHNKKNTSKAGQKQEQCQDMEVPSGTVLSQETPIKINAWKSTEDLMLFCEDDPKPVLPIIPTSIVSSMARLSEGQTDVYNLWDTDAVPVPSEKTPSLQTNVSLVKNLDSTITKTVTGNPLQMPLEKQPAAKSCDTLTTLQAHWPSSQEEFIGPHLRTSKSDSTFRNQASVETLYVSPSFTTFDPMKETVISKGHQKATRSGLVPMEDENLKTLATWVSAASEGTFSFSTLSVSSPDSASPVKSVHPLPPVLAGPSFWTLSRQQSSSASVKNIDKTARIHHPFAPRSPLSSDEKENEHLNLLEILPDNSGSAEEKTSSISSSNWVAFSTQNVDHFTSMSCSSSQATKDLSREPEADSSTNVLLGEVKNAIVTLHEDLSMVIRELNVISSRLVSMSGSSPQISKSLQFPQYSEAGSDQV", "length": 610, "header": "tr|E1BD08-1|E1BD08_BOVIN Isoform 1 of ENTH domain containing 1 OS=Bos taurus OX=9913 GN=ENTHD1 PE=4 SV=1 CANONICAL=E1BD08-1" }, "locus": { "chromosome": "5", "start_pos": 111251712, "end_pos": 111159509, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000431.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000431.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000431.2", "url": "https://www.ensembl.org/id/ENSBTAP00000000431.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 176, "start_aa": "Thr", "end_pos": 176, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr176", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538470", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538470", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q1Z2-1", "protein_name": "ENTH domain containing 1", "gene_name": "Enthd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFRRQVKNFVKNYSDAEKKVREATSNDPWGPSSSLMLAISDMTFNAASLSEIMHMLWQRLSDHGKNWRHVYKSLALMDYLIKNGSRKVIQYCREGVCNLQMLKDFQHIDEAGKDQGHYIRERSKQVITLLMDEQLLHKEREVATWTRQRTSYSMSFPSRLSATGTSPTVCTSVLIPESLTSEKKHSQDCKKTAGLCSKKNTSKARLRLEQCQDVPSPAGTSLPLYFPSLGMKAWKSTEDLTLLYSYEHPKQPVTRLPPSFTSPASWLSEGEAEICNLWDTEAVSTPPEKNPSMQTSVSLGKKLESAIANTITESPPQTPQEKQMAAKSFEMPTPLPAFWPSGKDEFVSLALRMSKSESIFHTQSSVETLYVSPTFKTISPLNETSQDLQTPAQFSICQMEDVCLKPLAMRGEWTPKQASEAVSAASEVASSFSTLSISPPDLAHPEKSARCFIPVMASSSFWTLPQPQSPSDPLTDQNEAVRVRHPFAPTSTASSDNEEYPSLPDNSDSTMKEPSYSFSSGRGAFSTLTRAHFPGLPQASFRFQESAGLSRDSESRAICTLLGEVKSAVVRLHDDLSLVIQELSVINSRLGNLSGSSPTVSETLQDPQSPRGSPDPV", "length": 618 }, "evidence": [ { "id": "E1BD08", "url": "https://omabrowser.org/oma/group/E1BD08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYW4-1", "protein_name": "ENTH domain-containing protein 1", "gene_name": "ENTHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFRRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWHRLNDHGKNWRHVYKSLTLMDYLIKNGSKKVIQHCREGFCNLQTLKDFQHIDEAGKDQGYYIREKSKQVITLLMDEPLLCKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPTPDISASEKKYKLPKFGRLHNKRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGFQSTKDFPQEPEAKNSISVLLREVKRAIARLHEDLSTVIQELNVINNILMSMSLNSSQISQSSQVPQSSEGSSDQI", "length": 607 }, "evidence": [ { "id": "E1BD08", "url": "https://omabrowser.org/oma/group/E1BD08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "clathrin vesicle coat", "id": "GO:0030125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030125", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BD08", "url": "https://www.uniprot.org/uniprotkb/E1BD08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 610, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD08" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD08" }, { "id": "PS50942", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50942" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ENTH", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 141, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 176 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD12-1", "uniprot_ac": "E1BD12", "uniprot_id": "E1BD12_BOVIN", "mass": { "chemical_mass": 132588.0, "monoisotopic_mass": 132588.0 }, "refseq": {}, "gene_names": [ { "name": "VWA5B2", "type": "recommended", "evidence": [ { "id": "E1BD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD12" } ] } ], "protein_names": [ { "name": "von Willebrand factor A domain containing 5B2", "type": "synonym", "evidence": [ { "id": "E1BD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD12/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD12", "url": "https://www.uniprot.org/uniprotkb/E1BD12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VWA5B2", "url": "https://www.uniprot.org/uniprotkb/E1BD12", "locus": { "chromosome": "1", "start_pos": 82932913, "end_pos": 82945908, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040399", "url": "https://www.ensembl.org/id/ENSBTAG00000040399" } ] } } ], "crossref": [ { "id": "E1BD12", "url": "https://alphafold.ebi.ac.uk/entry/E1BD12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040399", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040399", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BD12", "url": "https://www.orthodb.org/?gene=E1BD12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46299", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46299", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46299:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46299:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13757", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13757", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13768", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13768", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BD12", "url": "https://www.uniprot.org/uniprotkb/E1BD12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD12-1", "url": "https://www.uniprot.org/uniprotkb/E1BD12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGLYCPSSWTPLPLTDSWVRACANGPCLSLRARLTYHNPQPQPVDGVFVYPLAEAEVVSGFEAEAAGRRVSFQLQSRRRSQAACCSALGPALGASTPRRCAQGHLVLDLAQARSTLVLPTGLIAAAGTMTVTLRSSRELPSRPDGVLHVALPSVLTPLAPPGPPGPPRPPGLCDDRLGLCPTSCFGVSSPQGEGPAWEESAAPRDVFLGPARCPAPYTFSFEMLVTGPCLLAGLESPSHALRADAPPHASSAATICVTLAEGHRCDRALEILLHPSEPHQPHLMLEAGSLSSAEYEARVRARRDFQRLLRRDSDGDRQVCFLQRRFHKDILLNPVLVLSFCPDLSSKPGHLGTATRELLFLLDGSSVAHKDAIVLAVKSLPPQTLINLAMFGISVQPLFPESRPCSDEAVQLICESVEMLQAVDGTPDVWAALDWALGQPQQRAHPRQLFLLTAASPMAAVTHQTLELMRWHRGAARCFSFGLGRACRQLLQGLSAVSRGQAYFLRPGERLQPMLVQALRKALEPALSDISVDWFVPDAVEALLTPREIPALYPGDQLLGYCSLFRVDSFRSQPPGGQEPGWQSLGGSVFPSPEEAPSATSPGTEPTGTSEPLGTGTVSAELSSPWVAGDSERSTDALTDPVTDPGPNPSSDTAIWHRIFQSSYIREQYVLTHCSASPEPGPGSTGSSASPVSQGPGSPEGNTPLDPPSQQGCRSLAWGESASSRSCPLPPSPLAPVKTGALSAEVLGRRRRVALAGRSLSSPQGRVNPVPGCPRHPSLGVAPDGPGPEPGQQLGRGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPLSGELAPPAVAQPPQAPRCHVVIRALCGEQPMCWEVGVGLETLWGPQDDGSLPPSPPERDNAWDQALHRLTAASVVRDNEQLALRRGGETRADRGHARRSWLRALQTSKVSSAPSCFTCPVAVDATTREVLPSALQVQSSEPAEPAGTPPISQSHVDAAPFPTVVHSKGGWDPDQTGNSSSALGDHAAPIGGSHRPLPRPPSRISLGRWKSRGPDSHRPCSPNTGQVNDSNSEGSGHDYLPLVRLQEAPGSFRLDALFCAAVRISQERLCRASPFAAHRASLSPTSASSPWALLAPSVGQGSSATASCSPSPSSGSEGPGQVDSGRGSDTEASEGLEGPGGADLRGRTWATAVALAWLEHRCAGAFGEWELAAAKADCWLRAQHLPDGLDLANLKAAARGLFLLLRHWDQNLQLHLLCYSPANM", "length": 1251, "header": "tr|E1BD12-1|E1BD12_BOVIN Isoform 1 of von Willebrand factor A domain containing 5B2 OS=Bos taurus OX=9913 GN=VWA5B2 PE=4 SV=4 CANONICAL=E1BD12-1" }, "isoforms": [ { "isoform_ac": "E1BD12-1", "url": "https://www.uniprot.org/uniprotkb/E1BD12/entry#E1BD12-1", "sequence": { "sequence": "MPGLYCPSSWTPLPLTDSWVRACANGPCLSLRARLTYHNPQPQPVDGVFVYPLAEAEVVSGFEAEAAGRRVSFQLQSRRRSQAACCSALGPALGASTPRRCAQGHLVLDLAQARSTLVLPTGLIAAAGTMTVTLRSSRELPSRPDGVLHVALPSVLTPLAPPGPPGPPRPPGLCDDRLGLCPTSCFGVSSPQGEGPAWEESAAPRDVFLGPARCPAPYTFSFEMLVTGPCLLAGLESPSHALRADAPPHASSAATICVTLAEGHRCDRALEILLHPSEPHQPHLMLEAGSLSSAEYEARVRARRDFQRLLRRDSDGDRQVCFLQRRFHKDILLNPVLVLSFCPDLSSKPGHLGTATRELLFLLDGSSVAHKDAIVLAVKSLPPQTLINLAMFGISVQPLFPESRPCSDEAVQLICESVEMLQAVDGTPDVWAALDWALGQPQQRAHPRQLFLLTAASPMAAVTHQTLELMRWHRGAARCFSFGLGRACRQLLQGLSAVSRGQAYFLRPGERLQPMLVQALRKALEPALSDISVDWFVPDAVEALLTPREIPALYPGDQLLGYCSLFRVDSFRSQPPGGQEPGWQSLGGSVFPSPEEAPSATSPGTEPTGTSEPLGTGTVSAELSSPWVAGDSERSTDALTDPVTDPGPNPSSDTAIWHRIFQSSYIREQYVLTHCSASPEPGPGSTGSSASPVSQGPGSPEGNTPLDPPSQQGCRSLAWGESASSRSCPLPPSPLAPVKTGALSAEVLGRRRRVALAGRSLSSPQGRVNPVPGCPRHPSLGVAPDGPGPEPGQQLGRGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPLSGELAPPAVAQPPQAPRCHVVIRALCGEQPMCWEVGVGLETLWGPQDDGSLPPSPPERDNAWDQALHRLTAASVVRDNEQLALRRGGETRADRGHARRSWLRALQTSKVSSAPSCFTCPVAVDATTREVLPSALQVQSSEPAEPAGTPPISQSHVDAAPFPTVVHSKGGWDPDQTGNSSSALGDHAAPIGGSHRPLPRPPSRISLGRWKSRGPDSHRPCSPNTGQVNDSNSEGSGHDYLPLVRLQEAPGSFRLDALFCAAVRISQERLCRASPFAAHRASLSPTSASSPWALLAPSVGQGSSATASCSPSPSSGSEGPGQVDSGRGSDTEASEGLEGPGGADLRGRTWATAVALAWLEHRCAGAFGEWELAAAKADCWLRAQHLPDGLDLANLKAAARGLFLLLRHWDQNLQLHLLCYSPANM", "length": 1251, "header": "tr|E1BD12-1|E1BD12_BOVIN Isoform 1 of von Willebrand factor A domain containing 5B2 OS=Bos taurus OX=9913 GN=VWA5B2 PE=4 SV=4 CANONICAL=E1BD12-1" }, "locus": { "chromosome": "1", "start_pos": 82944814, "end_pos": 82933520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052221.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052221.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047929.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047929.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 990, "start_aa": "Thr", "end_pos": 990, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr990", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1005, "end_pos": 1007, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1055, "end_pos": 1057, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1251, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD12" }, { "id": "PS51468", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51468" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VIT", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 138, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 990 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1005, "end_pos": 1007 }, { "start_pos": 1055, "end_pos": 1057 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD39-1", "uniprot_ac": "E1BD39", "uniprot_id": "E1BD39_BOVIN", "mass": { "chemical_mass": 28513.0, "monoisotopic_mass": 28513.0 }, "refseq": { "ac": "NP_001178277", "name": "protein orai-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277" }, "gene_names": [ { "name": "ORAI2", "type": "recommended", "evidence": [ { "id": "E1BD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ] }, { "name": "ORAI2", "type": "synonym", "evidence": [ { "id": "NP_001178277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277" } ] } ], "protein_names": [ { "name": "ORAI calcium release-activated calcium modulator 2", "type": "synonym", "evidence": [ { "id": "E1BD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD39/entry#names_and_taxonomy" } ] }, { "name": "protein orai-2", "type": "synonym", "evidence": [ { "id": "NP_001178277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277" } ] } ], "function": [ { "annotation": "Orai2 is specifically up-regulated during the G2/M phase, negatively modulates the store-operated Ca(2+) entry activity, and may contribute to the regulation of cell cycle progression in brain capillary endothelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001178277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277" }, { "database": "PubMed", "id": "25748572", "url": "https://glygen.org/publication/PubMed/25748572" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORAI2", "url": "https://www.uniprot.org/uniprotkb/E1BD39", "locus": { "chromosome": "25", "start_pos": 34599598, "end_pos": 34611518, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012050", "url": "https://www.ensembl.org/id/ENSBTAG00000012050" } ] } } ], "crossref": [ { "id": "E1BD39", "url": "https://alphafold.ebi.ac.uk/entry/E1BD39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012050", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012050", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511233", "url": "https://www.ncbi.nlm.nih.gov/gene/511233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511233", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511233", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CELAILC", "url": "https://omabrowser.org/oma/group/CELAILC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD39", "url": "https://www.orthodb.org/?gene=E1BD39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31501", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31501:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD39-1", "url": "https://www.uniprot.org/uniprotkb/E1BD39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTELNVPVDPSAPACSEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARHQPGPPPGPGGHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV", "length": 254, "header": "tr|E1BD39-1|E1BD39_BOVIN Isoform 1 of ORAI calcium release-activated calcium modulator 2 OS=Bos taurus OX=9913 GN=ORAI2 PE=3 SV=1 CANONICAL=E1BD39-1" }, "isoforms": [ { "isoform_ac": "E1BD39-1", "url": "https://www.uniprot.org/uniprotkb/E1BD39/entry#E1BD39-1", "sequence": { "sequence": "MSTELNVPVDPSAPACSEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARHQPGPPPGPGGHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV", "length": 254, "header": "tr|E1BD39-1|E1BD39_BOVIN Isoform 1 of ORAI calcium release-activated calcium modulator 2 OS=Bos taurus OX=9913 GN=ORAI2 PE=3 SV=1 CANONICAL=E1BD39-1" }, "locus": { "chromosome": "25", "start_pos": 34605528, "end_pos": 34600096, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015982.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015982.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015982.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015982.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Regulation of store-operated Ca2+ entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells.", "journal": "Biochemical and biophysical research communications", "date": "2015-04-10", "authors": "Kito Hiroaki, Yamamura Hisao, Suzuki Yoshiaki, Yamamura Hideto, Ohya Susumu, Asai Kiyofumi, Imaizumi Yuji", "evidence": [ { "database": "RefSeq", "id": "NP_001178277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178277" } ], "reference": [ { "type": "PubMed", "id": "25748572", "url": "https://glygen.org/publication/PubMed/25748572" } ] } ], "pathway": [ { "id": "bta:511233", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511233", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "store-operated calcium entry", "id": "GO:0002115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002115", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "store-operated calcium channel activity", "id": "GO:0015279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015279", "evidence": [ { "database": "UniProtKB", "id": "E1BD39", "url": "https://www.uniprot.org/uniprotkb/E1BD39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD39-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD39-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD39" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BD42-1", "uniprot_ac": "E1BD42", "uniprot_id": "E1BD42_BOVIN", "mass": { "chemical_mass": 38073.0, "monoisotopic_mass": 38073.0 }, "refseq": {}, "gene_names": [ { "name": "NUP37", "type": "recommended", "evidence": [ { "id": "E1BD42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ] } ], "protein_names": [ { "name": "Nucleoporin Nup37", "type": "recommended", "evidence": [ { "id": "E1BD42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD42/entry#names_and_taxonomy" } ] }, { "name": "Nup107-160 subcomplex subunit Nup37", "type": "synonym", "evidence": [ { "id": "E1BD42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD42/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42#function" }, { "database": "UniProtKB", "id": "ARBA00053706", "url": "https://www.uniprot.org/uniprotkb/ARBA00053706#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUP37", "url": "https://www.uniprot.org/uniprotkb/E1BD42", "locus": { "chromosome": "5", "start_pos": 65900759, "end_pos": 65951480, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000022", "url": "https://www.ensembl.org/id/ENSBTAG00000000022" } ] } } ], "crossref": [ { "id": "E1BD42", "url": "https://alphafold.ebi.ac.uk/entry/E1BD42", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000022", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000022", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BD42", "url": "https://www.orthodb.org/?gene=E1BD42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22806:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22806:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159227", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159227", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159230", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159230", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1855170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1855196", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855196", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1855229", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855229", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3232142", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232142", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3301854", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3301854", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4085377", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085377", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4570464", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4615885", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9615933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD42-1", "url": "https://www.uniprot.org/uniprotkb/E1BD42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQDATRNAAYTVDCEDYVHVVEFNPFESGDSGNLIAYGGNNFVFVGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHSDFINGLVFDPREGQEIASVSDDHTCRIWNLEGIQTAHFVLHSPGMSVCWHPEETFKVVEFSLFFLQLMVAEKNGTIRFYDLLAQQAILSLESEQMPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQDKRPVHMDRACLFRWSTVNENLFATTGYPGKMMSQFQIHHLGHPQPILIGSVAVGSGLSWHRTLPLCAIGSDHKLLFWVTEM", "length": 336, "header": "tr|E1BD42-1|E1BD42_BOVIN Isoform 1 of Nucleoporin Nup37 OS=Bos taurus OX=9913 GN=NUP37 PE=4 SV=2 CANONICAL=E1BD42-1" }, "isoforms": [ { "isoform_ac": "E1BD42-1", "url": "https://www.uniprot.org/uniprotkb/E1BD42/entry#E1BD42-1", "sequence": { "sequence": "MKQDATRNAAYTVDCEDYVHVVEFNPFESGDSGNLIAYGGNNFVFVGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHSDFINGLVFDPREGQEIASVSDDHTCRIWNLEGIQTAHFVLHSPGMSVCWHPEETFKVVEFSLFFLQLMVAEKNGTIRFYDLLAQQAILSLESEQMPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQDKRPVHMDRACLFRWSTVNENLFATTGYPGKMMSQFQIHHLGHPQPILIGSVAVGSGLSWHRTLPLCAIGSDHKLLFWVTEM", "length": 336, "header": "tr|E1BD42-1|E1BD42_BOVIN Isoform 1 of Nucleoporin Nup37 OS=Bos taurus OX=9913 GN=NUP37 PE=4 SV=2 CANONICAL=E1BD42-1" }, "locus": { "chromosome": "5", "start_pos": 65951420, "end_pos": 65900908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000024.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000024.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000024.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000024.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-159227", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159227", "resource": "Reactome", "description": "Transport of the SLBP independent Mature mRNA" }, { "id": "R-BTA-159230", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159230", "resource": "Reactome", "description": "Transport of the SLBP Dependant Mature mRNA" }, { "id": "R-BTA-159231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "resource": "Reactome", "description": "Transport of Mature mRNA Derived from an Intronless Transcript" }, { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" }, { "id": "R-BTA-1855170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855170", "resource": "Reactome", "description": "IPs transport between nucleus and cytosol" }, { "id": "R-BTA-1855196", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855196", "resource": "Reactome", "description": "IP3 and IP4 transport between cytosol and nucleus" }, { "id": "R-BTA-1855229", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855229", "resource": "Reactome", "description": "IP6 and IP7 transport between cytosol and nucleus" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-3108214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" }, { "id": "R-BTA-3232142", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232142", "resource": "Reactome", "description": "SUMOylation of ubiquitinylation proteins" }, { "id": "R-BTA-3301854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3301854", "resource": "Reactome", "description": "Nuclear Pore Complex (NPC) Disassembly" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" }, { "id": "R-BTA-4085377", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085377", "resource": "Reactome", "description": "SUMOylation of SUMOylation proteins" }, { "id": "R-BTA-4551638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "resource": "Reactome", "description": "SUMOylation of chromatin organization proteins" }, { "id": "R-BTA-4570464", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "resource": "Reactome", "description": "SUMOylation of RNA binding proteins" }, { "id": "R-BTA-4615885", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "resource": "Reactome", "description": "SUMOylation of DNA replication proteins" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9615933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "resource": "Reactome", "description": "Postmitotic nuclear pore complex (NPC) reformation" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear pore outer ring", "id": "GO:0031080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031080", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "E1BD42", "url": "https://www.uniprot.org/uniprotkb/E1BD42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD42-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 336, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD42-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD42" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD49-1", "uniprot_ac": "E1BD49", "uniprot_id": "E1BD49_BOVIN", "mass": { "chemical_mass": 78179.0, "monoisotopic_mass": 78179.0 }, "refseq": { "ac": "NP_001192940", "name": "FAD-dependent oxidoreductase domain-containing protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192940" }, "gene_names": [ { "name": "FOXRED2", "type": "recommended", "evidence": [ { "id": "E1BD49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ] }, { "name": "FOXRED2", "type": "synonym", "evidence": [ { "id": "NP_001192940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192940" } ] } ], "protein_names": [ { "name": "FAD-dependent oxidoreductase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "E1BD49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD49/entry#names_and_taxonomy" } ] }, { "name": "FAD-dependent oxidoreductase domain-containing protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192940" } ] } ], "function": [ { "annotation": "Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.", "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49#function" }, { "database": "UniProtKB", "id": "ARBA00056122", "url": "https://www.uniprot.org/uniprotkb/ARBA00056122#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXRED2", "url": "https://www.uniprot.org/uniprotkb/E1BD49", "locus": { "chromosome": "5", "start_pos": 74904978, "end_pos": 74919080, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000015", "url": "https://www.ensembl.org/id/ENSBTAG00000000015" } ] } } ], "crossref": [ { "id": "E1BD49", "url": "https://alphafold.ebi.ac.uk/entry/E1BD49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000015", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000015", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532871", "url": "https://www.ncbi.nlm.nih.gov/gene/532871", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532871", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532871", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGQAYQC", "url": "https://omabrowser.org/oma/group/KGQAYQC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD49", "url": "https://www.orthodb.org/?gene=E1BD49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43539", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43539", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43539:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43539:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13738", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13738", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192940", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD49-1", "url": "https://www.uniprot.org/uniprotkb/E1BD49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLSTVAPLWGAPGLLLTIALHLALYLRPAQAWAPVHRDYCVLGAGPAGLQMAYFLQRAGRDYMVFERAPVPGSFFTRYPRHRKLISINKRYTGKTNAEFNLRHDWNSLLSHDPRLLFRHYSDAYYPDANDMVRYLSDFAERLGLHVLYNTTIAHVTVNKDRGAWNGHYFILTDHRGQAYQCSVLLVATGLSVPNQVDFPGSEYVDGYESVSVDPKDFEGQNVLILGRGNSAFETAENIFSVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAIVKDHKGKFHITLKLFMEEFFNQSSDAIPLPQDNNDNFAMRVAYDRVIRCLGWKFDFSIFSKSLRLSSGSELSEKYPLVRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEQRHHGVAWPSTEHPITHLASAIIRRINEASGLYQMFSVLADVVLLKENATTFEYLEEFPMQMLAQLETITGKRARHGLFVINMEYGRNYSGPDKDVFFSDRSVGHMEDAWLSNFLHPVIYYYRHLPTEQEVRFRPAGWPLPRPSALHHVVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFALTHQKLPPFCQQGYLRTQGLVGTESLRQHGVESGLLWDSATMGQNQGASDQRPGDHGPGGHPLAPGPPVSPFNSNKEEL", "length": 690, "header": "tr|E1BD49-1|E1BD49_BOVIN Isoform 1 of FAD-dependent oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=FOXRED2 PE=3 SV=3 CANONICAL=E1BD49-1" }, "isoforms": [ { "isoform_ac": "E1BD49-1", "url": "https://www.uniprot.org/uniprotkb/E1BD49/entry#E1BD49-1", "sequence": { "sequence": "MGLSTVAPLWGAPGLLLTIALHLALYLRPAQAWAPVHRDYCVLGAGPAGLQMAYFLQRAGRDYMVFERAPVPGSFFTRYPRHRKLISINKRYTGKTNAEFNLRHDWNSLLSHDPRLLFRHYSDAYYPDANDMVRYLSDFAERLGLHVLYNTTIAHVTVNKDRGAWNGHYFILTDHRGQAYQCSVLLVATGLSVPNQVDFPGSEYVDGYESVSVDPKDFEGQNVLILGRGNSAFETAENIFSVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAIVKDHKGKFHITLKLFMEEFFNQSSDAIPLPQDNNDNFAMRVAYDRVIRCLGWKFDFSIFSKSLRLSSGSELSEKYPLVRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEQRHHGVAWPSTEHPITHLASAIIRRINEASGLYQMFSVLADVVLLKENATTFEYLEEFPMQMLAQLETITGKRARHGLFVINMEYGRNYSGPDKDVFFSDRSVGHMEDAWLSNFLHPVIYYYRHLPTEQEVRFRPAGWPLPRPSALHHVVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFALTHQKLPPFCQQGYLRTQGLVGTESLRQHGVESGLLWDSATMGQNQGASDQRPGDHGPGGHPLAPGPPVSPFNSNKEEL", "length": 690, "header": "tr|E1BD49-1|E1BD49_BOVIN Isoform 1 of FAD-dependent oxidoreductase domain-containing protein 2 OS=Bos taurus OX=9913 GN=FOXRED2 PE=3 SV=3 CANONICAL=E1BD49-1" }, "locus": { "chromosome": "5", "start_pos": 74918371, "end_pos": 74905034, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000015.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000015.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000015.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000015.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532871", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532871", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480K665-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "FOXRED2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLSAAAPLWGPLGLLLAIALHPALSVSPASEPAHRDYCVLGAGPAGLQMAYFLQRAGRDYTVFERAARPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPQLLFRHYSSAYFPDASDMVRYLGDFADRLGLRVRYNTTIAHVTLNKDGQAWNGHYFILTDQKGQTFQCSVLLVATGLSVPNQVDFPGAEYMDGYESVSVDPKDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLANLAIVKDHKGKFHITLKLYLEVGNHSADAIPLPEDESDNFAMRVPYDRVIRCLGWNFDFSIFSKSLRLSSGGDFSKKYPLVRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTARAVHRLLEQRHHGVAWPATEHPVTQLASAIIRRINEASGLYQMFGVLADVVLMKENATAFEYLEEFPMQMLAQLETITGRQARHGLFVVNMEYGKNFSGPDKDVFYYDRSVGYTEDAWLSNFLHPVIYYYRHLPTEQEVRFRPADWPLPRPTAIHHVVEDFLTDWTAPVGHILPLRRFLENCLDTDLRNFYAESCFLFALTRQKLPPFCQQGYLRTQGLVGTESLRRHGVESGLLQDYAAEGWPWQDSSQQPDDHGPGGYTLAPGPPVQALDSNKEEL", "length": 687 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LPK0-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "Foxred2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSWVPGFSPGPAPDPWEAQALGFSFLGKAGCHQLPTTRCEASPLLCRRMGPSGLLVALALHLAVCSRPHRDYCVLGAGPAGLQMAALLHRAGRDYEVFERESAPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSDDPHLLFRHYSQAYFPDASDMVRYLGDFAQRLGLRVLYNTNITHVTLDKDPQAWNGHYFILRDQKGQVYQCSVLLVATGLAVPKLVDFPGSEYVEGYESVSVDPEDFVGQNVLILGHGNSAFETAENILGVTNFVHMLSRSRVRLSWATHYVGDVRAINNGLLDTYQLKSLDGLLESDLEYLALVKDSKGKFHITLKFLLENSSNQSADSIPLPQDDNDNFAMRVAYDRVIRCLGWKFDFSIFNQSLRLSSGTEFSKKYPLIKASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHGITWPSTQYPITQLTSSIIRRVNEASGLYQMFSVLADIILLKENATAFEYLEEFPIQMLAQLEMLTGRTARHGIFVINMEYGKNFSGPEKDVFYYDRSVAHIEDAWMSNFLHPVIYYYRHLPTEQDMRFRPAQWPLPRPVAIHHIVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFTLTRQKLPPFCQQGYLRMQGLSSTKSLRQHGVESRLLQDYTAMENSSRWLDDHSSAPGPLTQFLDSNREEL", "length": 714 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0UXS1-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "foxred2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVIQLVFRLLCVLDLLLAVSASGLHGRNRTLSHEYCVLGAGPAGLQMGYFLSRSQRDYIILERNAGPGSFFNIYPRHRKLISINKIYTGRRNKEFNLRHDWNSLLSDRPDLLFQRISRKLYPSADDFPHYLSLFEKELGLKVKYGTDVGRIKASDFNGHQGYVLTDQNGVNYQCRVLLVSTGLWVPQEVDFRGSDLVEGYESIPTDPEEFKDQAVLILGKGNSAFETAQSILGRASRIHLYSPSPVRLAWQTHYVGDLRAVNNELLDTYQLKSLDGLVEGRLEDIAIVRRAKDRGKRRAAKKRNSTSTKRNEPLYLTLTELLDDQNDTNISNVTGQNLPGYHTDNFSLRQPYDRVIRCLGFRFNFSIFDGSARPPQSSGARGRLPGVTAWYEGRGTPNMFVLGIAAHSRDYRMSAGGFIHGFRYTVRAVHKILEQRYHNIAWPTTNIPISQLQSWILRRVNEASGTYQMFGVLGDIILLQGSHCEYLEEFPLQALPQLSALSGRSISDHGLLVLVMQYGLNHTDTLGPGRAESEWTKAWKSNFLHPVLYYYKTLPTDKDMRQRPVGWPLPRPEAVHHMVEDFLTEWDQPISHSQPLRRFLEHCLKTDLRAFYAESCFLLSLTSRNPPLFCRQGYLRKQGIMGNRHLWQHAREAGLMEDAALSEDASVPEYLNHAGAAVISTVNFDL", "length": 687 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1C6M2-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "FOXRED2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARGLFLRLVLSALCAAGAAAFLYHDYCVLGAGPAGLQAAYFLQRAGRDYVVFERSHAPGSFFAIYPRHRKLISINKRHTGKSNSEFNLRHDWNSLLSHEPRLLFRRYSRQFFPHADAMVRYLEDFAAMLGLRIRYDTAIVHVTLEKDPRAWNGHYFVLSDQNRQSYKCSCLLVATGTWVPNVVNFPGSEYVEGYETVSTNPEDFAGQTVLILGRGNSAFETAENILGVTNFIHMVSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLEGDLEDLAIVKDKKGKLHITLRFYLENRNTSAGIDGITLPQDELDNFATRAPYDRVIRCLGWKFDFSIYNRSLRMMPGRGNKSKYPQIKPSYESRGTRGLFVLGTASHSVDFRKSAGGFIHGFRYTTRAVHRLLENRHHGVPWPSAVYPITQLTNSIIKRVNEASGLYQMFSVLADIILLRENATAFEYLEEYPVGILAELETQTGRKAPAGLFVVIMEYGRNFSGDDKDVFYYNRAVGEAQHAWQSNFLHPVIYYYKRLPTEREMRLHPPDWPLPRPDAIHHIVEDFLTDWTAPNAHILPLRRFLENCLSTDLRNFFAESCFLFALTRQKLPPFCQQGYARMQGLTGSERLRRHAVEAGLLEDYAVTDFSGDKLPDSRQGSHDQLLRDHVIPLRPLHHLVNAKDEF", "length": 680 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IJ28-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "Foxred2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPLGLLLALAMHLAVCTRPHRDYCVLGAGPAGLQMAALLQRAGRDYEVFERESAPGSFFTRYPRHRKLISINKRHTGKANAEFNLRHDWNSLLSDDPRLLFRHYSKAYFPDASDMVHYLGDFAKCLGLRVLYNTNITHVTLDKDPQAWNGHYFILTDQNGQAYQCSVLLVATGLSVPKLVDFPGSEHVEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFVHMLSRSRVRLSWATHYVGDVRAINNGLLDTYQLKSLDGLLESDLEYLALVKDSKGKLHITLKFLLEENNSSQSADSIPLPQDENDNFAMRVAYDRVIRCLGWKFDFSIFNQSLRLSSGTEFSKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHGIAWPSTEHPITQLTSSIIRRVNEASGLYQMFSVLADIILLKENATAFEYLEEFPMQMLAQLETLTGRTARHGLFVINMEYGKNFSGPEKDVFYYDRSVAHIEDAWRSNFLHPVIYFYRHLPTEQDMRFRPAQWPLPRPVAVHHIVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFTLTRQRLPPFCQQGYLKMQGVSSTKSLRQHGVESRLLQDYTTMEDSNLWLGDQPSAPGPLTQSLDSNKEEL", "length": 666 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3USW5-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "Foxred2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPSGLLVALALHLAVCSRPHRDYCVLGAGPAGLQMAAFLHRAGRDYEVFERESAPGSFFTRYPRHRKLISINKRHTGKANAEFNLRHDWNSLLSDDPHLLFRHYSQAYFPDASDMVRYLGDFARRLGLHVLYNTNITHVTLDKDPQAWNGHYFILTDQKGQVYQCSVLLVATGLAVPKLVDFPGSEYVEGYESVSVDPEDFVGQNVLILGHGNSAFETAENILGVTNFVHMLSRSRVRLSWATHYVGDVRAINNGLLDTYQLKSLDGLLESDLEYLALVKDSKGKFHVTLKFLLENNSSQSADSIPLPEDDNDNFAMRVAYDRVIRCLGWTFDFSIFDQSLRLSSGTEFSKKYPLIKASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHGIPWPSTEYPITQLTSSIIRRVNEASGLYQMFSVLADIILLKENATAFEYLEEFPMQMLAQLEMLTGRTARHGLFVINMEYGKNFSGPEKDVFYYDRSVAHIEDAWMSNFLHPVIYYYRHLPTEQDMRFRPAQWPLPRPTAIHHIVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFTLTRQRLPPFCQQGYLRMQGLSSTKSLWQHGVESRLLQDYTAMENSNRWLGDHSTAPEPLTQSLDSNKEEL", "length": 665 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IWF2-1", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "FOXRED2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFVATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAFGKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHSVTWPATELPITQLTSSIVRRVNEASGLYQMFGVLADVILLKENSTAFEYLEEFPIQMLAQLETLTGRKAKHGLFVINMEYGRNFSGPDKDVFFDDRSVGHTEDAWQSNFLHPVIYYYRYLPTEQEVRFRPAHWPLPRPTAIHHIVEDFLTDWTAPIGHILPLRRFLENCLDTDLRSFYAESCFLFALTRQKLPPFCQQGYLRMQGLVSTESLWQHRVESRLLRDYAPTGRRLEDSSQQLGDQEPLGSPLAPGPLAQSVDSNKEEL", "length": 684 }, "evidence": [ { "id": "E1BD49", "url": "https://omabrowser.org/oma/group/E1BD49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "E1BD49", "url": "https://www.uniprot.org/uniprotkb/E1BD49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 690, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 468, "end_pos": 470 }, { "start_pos": 508, "end_pos": 510 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD53-1", "uniprot_ac": "E1BD53", "uniprot_id": "E1BD53_BOVIN", "mass": { "chemical_mass": 47403.0, "monoisotopic_mass": 47403.0 }, "refseq": { "ac": "NP_001192253", "name": "docking protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192253" }, "gene_names": [ { "name": "DOK3", "type": "recommended", "evidence": [ { "id": "E1BD53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ] }, { "name": "DOK3", "type": "synonym", "evidence": [ { "id": "NP_001192253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192253" } ] } ], "protein_names": [ { "name": "Docking protein 3", "type": "synonym", "evidence": [ { "id": "E1BD53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD53/entry#names_and_taxonomy" } ] }, { "name": "docking protein 3", "type": "synonym", "evidence": [ { "id": "NP_001192253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192253" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOK3", "url": "https://www.uniprot.org/uniprotkb/E1BD53", "locus": { "chromosome": "7", "start_pos": 39004313, "end_pos": 39009596, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025401", "url": "https://www.ensembl.org/id/ENSBTAG00000025401" } ] } } ], "crossref": [ { "id": "E1BD53", "url": "https://alphafold.ebi.ac.uk/entry/E1BD53", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025401", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025401", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514894", "url": "https://www.ncbi.nlm.nih.gov/gene/514894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514894", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514894", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AQHRQEW", "url": "https://omabrowser.org/oma/group/AQHRQEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD53", "url": "https://www.orthodb.org/?gene=E1BD53", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD53-1", "url": "https://www.uniprot.org/uniprotkb/E1BD53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPLETPVKDGILYQQHVKFGKKCWRKVWGLLYAGGPSGVARLESWEVRDGGLGPAGDRSAGPGRRGERRIIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAEHRQAWMGPICQLAFPGTGESSSGSGEAEARQRSLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPYLLRLGQDAIQLSEPANPQALYTWPYCFLRKFGSDKGVFSFEAGRRCDSGEGLFAFSSARARDLCGALAAAIARQRERLPGPRPCPLPRATSLPSLEPPGELREGPPRPEAPGSRKMRAAEPGPQSLPPLLGPAVSEEPPAVLYASVCKRASVPPSAAAEHLYENLCAPDAGCRKLVEEGPGGGNPPDSPIYHNSQDLGWPGAAHDSSLEAQYRRLLELELADNGDEASGSGRPGAHSGFKAKLVTFLSRERKKGPAPCDRP", "length": 441, "header": "tr|E1BD53-1|E1BD53_BOVIN Isoform 1 of Docking protein 3 OS=Bos taurus OX=9913 GN=DOK3 PE=3 SV=1 CANONICAL=E1BD53-1" }, "isoforms": [ { "isoform_ac": "E1BD53-1", "url": "https://www.uniprot.org/uniprotkb/E1BD53/entry#E1BD53-1", "sequence": { "sequence": "MEPLETPVKDGILYQQHVKFGKKCWRKVWGLLYAGGPSGVARLESWEVRDGGLGPAGDRSAGPGRRGERRIIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAEHRQAWMGPICQLAFPGTGESSSGSGEAEARQRSLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPYLLRLGQDAIQLSEPANPQALYTWPYCFLRKFGSDKGVFSFEAGRRCDSGEGLFAFSSARARDLCGALAAAIARQRERLPGPRPCPLPRATSLPSLEPPGELREGPPRPEAPGSRKMRAAEPGPQSLPPLLGPAVSEEPPAVLYASVCKRASVPPSAAAEHLYENLCAPDAGCRKLVEEGPGGGNPPDSPIYHNSQDLGWPGAAHDSSLEAQYRRLLELELADNGDEASGSGRPGAHSGFKAKLVTFLSRERKKGPAPCDRP", "length": 441, "header": "tr|E1BD53-1|E1BD53_BOVIN Isoform 1 of Docking protein 3 OS=Bos taurus OX=9913 GN=DOK3 PE=3 SV=1 CANONICAL=E1BD53-1" }, "locus": { "chromosome": "7", "start_pos": 39009539, "end_pos": 39004520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035679.4", "url": "https://www.ensembl.org/id/ENSBTAT00000035679.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035549.3", "url": "https://www.ensembl.org/id/ENSBTAP00000035549.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514894", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514894", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RYG7-1", "protein_name": "Docking protein 3", "gene_name": "Dok3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESVETPVKDGLLYQQHMKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPGGDRPAGPGRRGERRIIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWMDPICQLAFPSTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVAEFPVVVQRTEATTRCQLKGPYLLVLGQDDIQLRETSKPQACYSWPYRFLRKFGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGAVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPEYELAPSRKLPLTDPGPQSLPLLLSPTQDGTASSLYASVCKQTSKHKATVEHLYENVFMLEASPGLSNGGPEAQEGPPGGRSPLGSPIYHNSEELSWPGSAHDSNLEAQYRRLLELELDDAGGAGRPGAQTGIKAKLVTLLTRERKKGPAPCDRP", "length": 444 }, "evidence": [ { "id": "E1BD53", "url": "https://omabrowser.org/oma/group/E1BD53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7L591-1", "protein_name": "Docking protein 3", "gene_name": "DOK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP", "length": 496 }, "evidence": [ { "id": "E1BD53", "url": "https://omabrowser.org/oma/group/E1BD53/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZK7-1", "protein_name": "Docking protein 3", "gene_name": "Dok3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESVEPPVKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPAGDRSTGPSRRGERRVIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWVDPICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGVVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPGFELPTPRKLPLTDPGPQSLPLLLSPTQEGPASGLYASVCKQTSKHTGTAEHLYENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSWPGSAQDSNLEAQYRRLLELELDEAGSAGRSGAQAGIKAKLVTLLTRERKKGPAPCDRP", "length": 444 }, "evidence": [ { "id": "E1BD53", "url": "https://omabrowser.org/oma/group/E1BD53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "E1BD53", "url": "https://www.uniprot.org/uniprotkb/E1BD53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD53-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD53-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD53" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD53" }, { "id": "PS51064", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRS-type PTB", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 261, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD80-1", "uniprot_ac": "E1BD80", "uniprot_id": "E1BD80_BOVIN", "mass": { "chemical_mass": 35693.0, "monoisotopic_mass": 35693.0 }, "refseq": { "ac": "NP_001377446", "name": "olfactory receptor family 56 subfamily B member 2E", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446" }, "gene_names": [ { "name": "OR56B2E", "type": "recommended", "evidence": [ { "id": "E1BD80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ] }, { "name": "OR56B2C", "type": "synonym", "evidence": [ { "id": "E1BD80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ] }, { "name": "OR56B2E", "type": "synonym", "evidence": [ { "id": "NP_001377446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 56 subfamily B member 2E", "type": "synonym", "evidence": [ { "id": "E1BD80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD80/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 56 subfamily B member 2E", "type": "synonym", "evidence": [ { "id": "NP_001377446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446" } ] }, { "name": "putative olfactory receptor 56B2", "type": "synonym", "evidence": [ { "id": "NP_001377446", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR56B2E", "url": "https://www.uniprot.org/uniprotkb/E1BD80", "locus": { "chromosome": "15", "start_pos": 47432076, "end_pos": 47433035, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050762", "url": "https://www.ensembl.org/id/ENSBTAG00000050762" } ] } } ], "crossref": [ { "id": "E1BD80", "url": "https://alphafold.ebi.ac.uk/entry/E1BD80", "database": "AlphaFoldDB", "categories": [] }, { "id": "787810", "url": "https://www.ncbi.nlm.nih.gov/gene/787810", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787810", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787810", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FIANTCV", "url": "https://omabrowser.org/oma/group/FIANTCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD80", "url": "https://www.orthodb.org/?gene=E1BD80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377446", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD80-1", "url": "https://www.uniprot.org/uniprotkb/E1BD80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQDLGNFNSSKFQVSEFILLGFPGIHSWQHWLSLPLVLLYLLALSANILILIIINQEATLHQPMYYFLGILAVVDMGLATTIMPKILTILWFNAKTIGLPECFVQMYAIHSFVGMESGIFVCMAIDRYVAICQPLCYSSIITKSFVLKATVLMALRNSLTTIPIPVLAAQRHYCSKNQIEHCLCSNLGVTSLSCDDRTINSVYQLLLAWILMGSDLGFILVSYALILHSVLKLNSMEAISKALSTCTSHLILILFFYTVVIVISITHSATMMFPLIPVLLNVLHNVIPPALNPMVYALKNKELRQGLRKLLKLDLKGR", "length": 319, "header": "tr|E1BD80-1|E1BD80_BOVIN Isoform 1 of Olfactory receptor family 56 subfamily B member 2E OS=Bos taurus OX=9913 GN=OR56B2E PE=3 SV=2 CANONICAL=E1BD80-1" }, "isoforms": [ { "isoform_ac": "E1BD80-1", "url": "https://www.uniprot.org/uniprotkb/E1BD80/entry#E1BD80-1", "sequence": { "sequence": "MFQDLGNFNSSKFQVSEFILLGFPGIHSWQHWLSLPLVLLYLLALSANILILIIINQEATLHQPMYYFLGILAVVDMGLATTIMPKILTILWFNAKTIGLPECFVQMYAIHSFVGMESGIFVCMAIDRYVAICQPLCYSSIITKSFVLKATVLMALRNSLTTIPIPVLAAQRHYCSKNQIEHCLCSNLGVTSLSCDDRTINSVYQLLLAWILMGSDLGFILVSYALILHSVLKLNSMEAISKALSTCTSHLILILFFYTVVIVISITHSATMMFPLIPVLLNVLHNVIPPALNPMVYALKNKELRQGLRKLLKLDLKGR", "length": 319, "header": "tr|E1BD80-1|E1BD80_BOVIN Isoform 1 of Olfactory receptor family 56 subfamily B member 2E OS=Bos taurus OX=9913 GN=OR56B2E PE=3 SV=2 CANONICAL=E1BD80-1" }, "locus": { "chromosome": "15", "start_pos": 47433035, "end_pos": 47432079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045758.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045758.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043121.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043121.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787810", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787810", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GSI9-1", "protein_name": "Olfactory receptor family 56 subfamily B member 2J", "gene_name": "Or56b2j", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQILRDSSSSRFQVSEFILMGFPGIHSWQHWLSLPLALLYVLALIANILIVTFIYQEASLHQPMYHFLGILAIVDMGLATTIMPKILAILWFNAKAISFNECFAQMYAIHCFVAMESDIFVCMAIDRYVAIRRPLRYSSIVTESFVVKATVIMAFRNFVAPMSVPVLAAQRNYCSRNQINHCFCPNPGVTSLACDDRKIDSINQLFLAWAVMGSDLGLIIVSYALILPSVLRLNSPKAASQTLSTCTSHLILIFFFYTVIIVMPITHSAKMTVPVILLLLNVPHNVIPPALNPMVYALKNKELKEGFYLCSGWMPKEP", "length": 319 }, "evidence": [ { "id": "E1BD80", "url": "https://omabrowser.org/oma/group/E1BD80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "E1BD80", "url": "https://www.uniprot.org/uniprotkb/E1BD80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD80-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD80-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD80" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD80" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 297, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD81-1", "uniprot_ac": "E1BD81", "uniprot_id": "E1BD81_BOVIN", "mass": { "chemical_mass": 18009.0, "monoisotopic_mass": 18009.0 }, "refseq": { "ac": "XP_002689443", "name": "Rieske domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689443" }, "gene_names": [ { "name": "RFESD", "type": "recommended", "evidence": [ { "id": "E1BD81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD81" } ] }, { "name": "RFESD", "type": "synonym", "evidence": [ { "id": "XP_002689443", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689443" } ] } ], "protein_names": [ { "name": "Rieske domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BD81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD81/entry#names_and_taxonomy" } ] }, { "name": "Rieske domain-containing protein", "type": "synonym", "evidence": [ { "id": "XP_002689443", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689443" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD81", "url": "https://www.uniprot.org/uniprotkb/E1BD81" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFESD", "url": "https://www.uniprot.org/uniprotkb/E1BD81", "locus": { "chromosome": "7", "start_pos": 94975462, "end_pos": 94964396, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000036242", "url": "https://www.ensembl.org/id/ENSBTAG00000036242" } ] } } ], "crossref": [ { "id": "E1BD81", "url": "https://alphafold.ebi.ac.uk/entry/E1BD81", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000036242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000036242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03467", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03467", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519915", "url": "https://www.ncbi.nlm.nih.gov/gene/519915", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519915", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAVPKWC", "url": "https://omabrowser.org/oma/group/SAVPKWC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD81", "url": "https://www.orthodb.org/?gene=E1BD81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21496", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21496", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21496:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21496:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22543", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22543", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689443", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689443", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BD81", "url": "https://www.uniprot.org/uniprotkb/E1BD81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD81-1", "url": "https://www.uniprot.org/uniprotkb/E1BD81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPGGSEQDPEMKEQYASVYVGREEDIKRSERITAVVHDREVVIFYHKGEFHAMDIRCYHSGGPLHLGEIEEFDGRACIVCPWHKYKITLETGEGLYQSIDPKDPSAKPMWCSKGIKQRIHTVTVDNGNIYVTLSNEPFKCDSDYYATGIFKVIPSSF", "length": 158, "header": "tr|E1BD81-1|E1BD81_BOVIN Isoform 1 of Rieske domain-containing protein OS=Bos taurus OX=9913 GN=RFESD PE=4 SV=1 CANONICAL=E1BD81-1" }, "isoforms": [ { "isoform_ac": "E1BD81-1", "url": "https://www.uniprot.org/uniprotkb/E1BD81/entry#E1BD81-1", "sequence": { "sequence": "MDPGGSEQDPEMKEQYASVYVGREEDIKRSERITAVVHDREVVIFYHKGEFHAMDIRCYHSGGPLHLGEIEEFDGRACIVCPWHKYKITLETGEGLYQSIDPKDPSAKPMWCSKGIKQRIHTVTVDNGNIYVTLSNEPFKCDSDYYATGIFKVIPSSF", "length": 158, "header": "tr|E1BD81-1|E1BD81_BOVIN Isoform 1 of Rieske domain-containing protein OS=Bos taurus OX=9913 GN=RFESD PE=4 SV=1 CANONICAL=E1BD81-1" }, "locus": { "chromosome": "7", "start_pos": 94974458, "end_pos": 94971940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050739.4", "url": "https://www.ensembl.org/id/ENSBTAT00000050739.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000047402.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519915", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519915", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TJB2-1", "protein_name": "Rieske domain-containing protein", "gene_name": "RFESD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDIDASEEDPEMKKSSAVCVGREEDIKKSERMTAIVHDREVVIFYHKGEYHAMDIRCYHSGGPLHLGDIEEFDGRPCIVCPWHKYKITLATGEGLYQSIDPKDPAAKPKWCSKGIKQRIHIVTVDNGNIYVTLSNEPFKCDSDFYATGVFKVIKSSS", "length": 157 }, "evidence": [ { "id": "E1BD81", "url": "https://omabrowser.org/oma/group/E1BD81/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZF58-1", "protein_name": "Rieske domain-containing protein", "gene_name": "Rfesd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPEISEQDEEQKTVCVGREEDIRRSERMTAVVHGREVVIFYHKGEYHAMDIRCYHSGGPLHLGEIEDFNGQSCIVCPWHKYKITLATGEGLYQSIDPKDPSAKPKWCSKGVKQRIHIVTVKNGNIYVTLSKEPFKCDSDYYATGEFKVIQSSS", "length": 154 }, "evidence": [ { "id": "E1BD81", "url": "https://omabrowser.org/oma/group/E1BD81/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H758-1", "protein_name": "Rieske domain-containing protein", "gene_name": "Rfesd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPGISEQDDEKKKHTSVCVGREDDIRKLERMTAVVHDREVVIFYHKGEYHAMDIRCYHAGGPLHLGEIEDFNGQSCIVCPWHKYKITLATGEGLYQSINPKDPSARPQWCSKGVKQRIHTVTVDNGNIYVTLSEEPFKCDSDFYATGEFKVIQSSS", "length": 157 }, "evidence": [ { "id": "E1BD81", "url": "https://omabrowser.org/oma/group/E1BD81/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8K2P6-1", "protein_name": "Rieske domain-containing protein", "gene_name": "Rfesd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPEISEQDEEKKKYTSVCVGREEDIRKSERMTAVVHDREVVIFYHKGEYHAMDIRCYHSGGPLHLGEIEDFNGQSCIVCPWHKYKITLATGEGLYQSINPKDPSAKPKWCSKGVKQRIHTVKVDNGNIYVTLSKEPFKCDSDYYATGEFKVIQSSS", "length": 157 }, "evidence": [ { "id": "E1BD81", "url": "https://omabrowser.org/oma/group/E1BD81/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TAC1-1", "protein_name": "Rieske domain-containing protein", "gene_name": "RFESD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLDGSAQDPEKREYSSVCVGREDDIKKSERMTAVVHDREVVIFYHKGEYHAMDIRCYHSGGPLHLGDIEDFDGRPCIVCPWHKYKITLATGEGLYQSINPKDPSAKPKWCSKGIKQRIHTVTVDNGNIYVTLSNEPFKCDSDFYATGDFKVIKSSS", "length": 157 }, "evidence": [ { "id": "E1BD81", "url": "https://omabrowser.org/oma/group/E1BD81/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BD81", "url": "https://www.uniprot.org/uniprotkb/E1BD81" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "E1BD81", "url": "https://www.uniprot.org/uniprotkb/E1BD81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD81-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 158, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD81-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD81" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD81" }, { "id": "PS51296", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rieske", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 132, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDA3-1", "uniprot_ac": "E1BDA3", "uniprot_id": "E1BDA3_BOVIN", "mass": { "chemical_mass": 45663.0, "monoisotopic_mass": 45663.0 }, "refseq": { "ac": "XP_002695793", "name": "ribosomal protein S6 kinase-related protein isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695793" }, "gene_names": [ { "name": "RSKR", "type": "recommended", "evidence": [ { "id": "E1BDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" } ] }, { "name": "RSKR", "type": "synonym", "evidence": [ { "id": "XP_002695793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695793" } ] } ], "protein_names": [ { "name": "Ribosomal protein S6 kinase related", "type": "synonym", "evidence": [ { "id": "E1BDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA3/entry#names_and_taxonomy" } ] }, { "name": "ribosomal protein S6 kinase-related protein isoform X5", "type": "synonym", "evidence": [ { "id": "XP_002695793", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695793" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDA3", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSKR", "url": "https://www.uniprot.org/uniprotkb/E1BDA3", "locus": { "chromosome": "19", "start_pos": 20055745, "end_pos": 20060305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011984", "url": "https://www.ensembl.org/id/ENSBTAG00000011984" } ] } } ], "crossref": [ { "id": "E1BDA3", "url": "https://alphafold.ebi.ac.uk/entry/E1BDA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011984", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011984", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05123", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05123", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527796", "url": "https://www.ncbi.nlm.nih.gov/gene/527796", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527796", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527796", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695793", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695793", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDA3", "url": "https://www.uniprot.org/uniprotkb/E1BDA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAVSCRQGHHAQMAASHKQGGNIRGPWVQGWKSLWSGVGTTRSGVKELWGLRGHQFLHREPLEPAPLLVEKPLPEWPVPQFINLFLPEFPIRPLSGHQQLKILGLVAKGSFGTVLKVLDCGQKAVFAVKVVPKAKVLQRDILRQCKEEVSIQRQINHPFVHSMGDSWQGKRHLFIMCSYCSTDLYSLWSAVGRLTEASIRLFAAELILVLCYLHDLGIIHRDVKMENILLDERGHLKLTDFGLSRHLPQGARAYTICGTLQYMAPEVLSGGPYNHAADWWSLGVLLFSLSTGKFPVPAERDHVAMLASVTHYDSEIPSSLNQGLSLLLHELLHQNPLHRLRYLHHFQVHPFFRGVAFDPELLQKHPVNFVLETQATQSSPSSESMFFKDFDCNLESFLVHPRLA", "length": 405, "header": "tr|E1BDA3-1|E1BDA3_BOVIN Isoform 1 of Ribosomal protein S6 kinase related OS=Bos taurus OX=9913 GN=RSKR PE=4 SV=3 CANONICAL=E1BDA3-1" }, "isoforms": [ { "isoform_ac": "E1BDA3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA3/entry#E1BDA3-1", "sequence": { "sequence": "MGAVSCRQGHHAQMAASHKQGGNIRGPWVQGWKSLWSGVGTTRSGVKELWGLRGHQFLHREPLEPAPLLVEKPLPEWPVPQFINLFLPEFPIRPLSGHQQLKILGLVAKGSFGTVLKVLDCGQKAVFAVKVVPKAKVLQRDILRQCKEEVSIQRQINHPFVHSMGDSWQGKRHLFIMCSYCSTDLYSLWSAVGRLTEASIRLFAAELILVLCYLHDLGIIHRDVKMENILLDERGHLKLTDFGLSRHLPQGARAYTICGTLQYMAPEVLSGGPYNHAADWWSLGVLLFSLSTGKFPVPAERDHVAMLASVTHYDSEIPSSLNQGLSLLLHELLHQNPLHRLRYLHHFQVHPFFRGVAFDPELLQKHPVNFVLETQATQSSPSSESMFFKDFDCNLESFLVHPRLA", "length": 405, "header": "tr|E1BDA3-1|E1BDA3_BOVIN Isoform 1 of Ribosomal protein S6 kinase related OS=Bos taurus OX=9913 GN=RSKR PE=4 SV=3 CANONICAL=E1BDA3-1" }, "locus": { "chromosome": "19", "start_pos": 20060305, "end_pos": 20056749, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015900.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015900.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015900.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015900.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527796", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527796", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "E1BDA3", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BDA3", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BDA3", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDA3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 405, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDA3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDA3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA3" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 353, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDA4-1", "uniprot_ac": "E1BDA4", "uniprot_id": "E1BDA4_BOVIN", "mass": { "chemical_mass": 46340.0, "monoisotopic_mass": 46340.0 }, "refseq": { "ac": "NP_001179423", "name": "solute carrier family 38 member 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179423" }, "gene_names": [ { "name": "SLC38A8", "type": "recommended", "evidence": [ { "id": "E1BDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ] }, { "name": "SLC38A8", "type": "synonym", "evidence": [ { "id": "NP_001179423", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179423" } ] } ], "protein_names": [ { "name": "Solute carrier family 38 member 8", "type": "synonym", "evidence": [ { "id": "E1BDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA4/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 38 member 8", "type": "synonym", "evidence": [ { "id": "NP_001179423", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179423" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC38A8", "url": "https://www.uniprot.org/uniprotkb/E1BDA4", "locus": { "chromosome": "18", "start_pos": 10337495, "end_pos": 10383172, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040086", "url": "https://www.ensembl.org/id/ENSBTAG00000040086" } ] } } ], "crossref": [ { "id": "E1BDA4", "url": "https://alphafold.ebi.ac.uk/entry/E1BDA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040086", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040086", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518625", "url": "https://www.ncbi.nlm.nih.gov/gene/518625", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518625", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518625", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDFWKRS", "url": "https://omabrowser.org/oma/group/QDFWKRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDA4", "url": "https://www.orthodb.org/?gene=E1BDA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950:SF226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950:SF226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179423", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T692", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T692", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T692-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T692-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGQTPGGGGLSEKPVPTASGPGLSSLGAVFILLKSALGAGLLNFPWAFHKAGGVAPAFLVELISLVFLISGLVVLGYAASVSGQATYQGVVGGLCGPAIGKLCEACFIINLLMISVAFLRVVGDQLEKLWDFILPSTPPVPQPWYTDQRFTLTLLCVLVILPLSAPREIGFQKYTSILGTLAACYLALVIVAQYYLRPQDLAREPRLESSPSSWTSVFSVFPTICFGFQCHEAAVSIYCSMRHQSLGHWALVSVLSLLACCLVYSLTGVYGFLTFGTDVSADILMSYPGSDGVVIVARVLFAVSIVTAYPIVLFLGRSVMQDFWRRGCGRACGLRALAEPTGPWVRMPLTVLWVTATLAMALFLPDLSEIIGIIGGISSFFIFIFPGLCLICAVSVEPIGPRVKCCLEAWGVVSVLVGAFIFGQSTVAAVMELL", "length": 435, "header": "tr|E1BDA4-1|E1BDA4_BOVIN Isoform 1 of Solute carrier family 38 member 8 OS=Bos taurus OX=9913 GN=SLC38A8 PE=3 SV=1 CANONICAL=E1BDA4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T692-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA4/entry#A0AAA9T692-1", "sequence": { "sequence": "MEGQTPGGGGLSEKPVPTASGPGLSSLGAVFILLKSALGAGLLNFPWAFHKAGGVAPAFLVELISLVFLISGLVVLGYAASVSGQATYQGVVGGLCGPAIGKLCEACFIINLLMISVAFLRVVGDQLEKLWDFILPSTPPVPQPWYTDQRFTLTLLCVLVILPLSAPREIGFQKYTSILGTLAACYLALVIVAQYYLRPQDLAREPRLESSPSSWTSVFSVFPTICFGFQCHEAAVSIYCSMRHQSLGHWALVSVLSLLACCLVYSLTGVYGFLTFGTDVSADILMSYPGSDGVVIVARVLFAVSIVTAYPIVLFLGRSVMQDFWRRGCGRACGLRALAEPTGPWVRMPLTVLWVTATLAMALFLPDLSEIIGIIGGISSFFIFIFPGLCLICAVSVEPIGPRVKYKRGFGFC", "length": 413, "header": "tr|A0AAA9T692-1|A0AAA9T692_BOVIN Computationally mapped isoform of Solute carrier family 38 member 8 OS=Bos taurus OX=9913 GN=SLC38A8 PE=3 SV=1 CANONICAL=E1BDA4-1" }, "locus": { "chromosome": "18", "start_pos": 10382141, "end_pos": 10338499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099471.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099471.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091299.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091299.1" } ] } }, { "isoform_ac": "E1BDA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA4/entry#E1BDA4-1", "sequence": { "sequence": "MEGQTPGGGGLSEKPVPTASGPGLSSLGAVFILLKSALGAGLLNFPWAFHKAGGVAPAFLVELISLVFLISGLVVLGYAASVSGQATYQGVVGGLCGPAIGKLCEACFIINLLMISVAFLRVVGDQLEKLWDFILPSTPPVPQPWYTDQRFTLTLLCVLVILPLSAPREIGFQKYTSILGTLAACYLALVIVAQYYLRPQDLAREPRLESSPSSWTSVFSVFPTICFGFQCHEAAVSIYCSMRHQSLGHWALVSVLSLLACCLVYSLTGVYGFLTFGTDVSADILMSYPGSDGVVIVARVLFAVSIVTAYPIVLFLGRSVMQDFWRRGCGRACGLRALAEPTGPWVRMPLTVLWVTATLAMALFLPDLSEIIGIIGGISSFFIFIFPGLCLICAVSVEPIGPRVKCCLEAWGVVSVLVGAFIFGQSTVAAVMELL", "length": 435, "header": "tr|E1BDA4-1|E1BDA4_BOVIN Isoform 1 of Solute carrier family 38 member 8 OS=Bos taurus OX=9913 GN=SLC38A8 PE=3 SV=1 CANONICAL=E1BDA4-1" }, "locus": { "chromosome": "18", "start_pos": 10382141, "end_pos": 10344787, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003939.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003939.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003939.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003939.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518625", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518625", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IC65-1", "protein_name": "Sodium-coupled neutral amino acid transporter 8", "gene_name": "Slc38a8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MERQTRGSRGLLEKPLPATTSPTLSSLGAVFILLKSALGAGLLNFPWAFYKAGGLVPTFLVALVSLLFLISGLVILGYAASISGQTTYQGVVRELCGAAMGKLCEACFLTNLIMISVAFLRVIGDQLEKLCDSLLPDVPQPWYAAQDFTLPLISALVIFPLSALREIAFQKYTSILGTLAACYLALVVTVQYYLWPQGLLRQPRPLLSPSPWTSVFSVFPTICFGFQSHEAAVSIYCSLRNQSLSHWALISVSSLLACCLVYSLTGVYGFLTFGTEVSADVLMSYPGNDTAIIVARILFAVSIVTVYPIVLFLGRSVMQDFWKKSYWATHGPPVLADPSGPWVRLPLTFLWVSVTLAMALFLPDLSEIISIIGGISSFFIFIFPGLCLICAVDMEPMGPRVKCCLEAWGTLSVLVGTFIFGQSTAEAMLELL", "length": 432 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A286ZZS8-1", "protein_name": "Solute carrier family 38 member 8", "gene_name": "SLC38A8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGPTPGGRGHAEKPVSAAARPNLSSLGAVFILLKSALGAGLLNFPWAFHKAGGVAPALLVELVSLVFLISGLVILGYAASVSGQATYQGVVGGLCGPAIGKLCEACFIINLLMISVAFLRVIGDQLDKLCDFLLPGAPPAPPPWYTDQRFTLTLLSLLLILPLSAPREIGFQKYTSILGTLAACYLALVVVAQYYLGPPGLAPEPLPAVSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRNQSLWHWALVSVLSLLACCLVYSLTGLYGFLTFGTEVSADILMSYPGSDGVIIVARVLFAVSIVTVYPIVLFLGRSVLQDFWRRGCCWACGPRALVEPSGPWVRMPLTVLWVTGTLALALFLPDLGEIIGIIGGISSFFIFIFPGLCLICAISVEPVGPQVRCCLEAWGVVSVLVGTFIFGQSTVAAVLELL", "length": 435 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A1V1-1", "protein_name": "Solute carrier family 38 member 8", "gene_name": "SLC38A8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERGEGQPLLGLRNTGSAGLSSAGAVFIMLKSALGAGLLSFPWAFNKAGGAVPAILVELGSLVFLVSGLAVLGYAAALSAQPTYQGVVRAVCGPAAGRLCELCFLLNLFMIAVALLRVVGDQLEKLCDSLYPPGALSEGSPWYVDQRFTLPALCALVIFPLSVPREIGFQKYSSILGTLAACYLMLVIVLKYHLQGGSLGLLQATRPPRASSWTSMFSVIPTICFGFQCHEACVAIYSSMRNQSFSHWVAVSVLSMLICLFIYSLTGLYGYLTFGEDVAPDVLMSYPGNDPVVITARLLFGVSIVTIYPIVVLLGRSVVQDLWAHPKFKAVLVSERHERQSRVALTISWMAATLAIALFVPDIGKVIELIGGISAFFIFIFPGMCLLCMTGTQAIGAPKKAVLITWGVLSVLGGTFVCGQSAALAVMGLLR", "length": 431 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6NNN8-1", "protein_name": "Solute carrier family 38 member 8", "gene_name": "SLC38A8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGQTPGSRGLPEKPHPATAAATLSSMGAVFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAVSGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLSAPREIAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRESHPSLSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTFGTEVSADVLMSYPGNDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFIFIFPGLCLICAMGVEPIGPRVKCCLEVWGVVSVLVGTFIFGQSTAAAVWEMF", "length": 435 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D4A0Y7-1", "protein_name": "Solute carrier family 38, member 8", "gene_name": "Slc38a8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGQTRGSRGLPEKPLPATTHPPLSSLGAVFILLKSALGAGLLNFPWAFYKAGGLVPTFLVALVSLVFLISGLVILGYAASVSGQTTYQGVVRELCGPAMGKLCEACFLTNLLMISVAFLRVIGDQLEKLCDSLLPDAPQPWYAAQSFTLPLISVLVIFPLSALRDIALQEYTSILGTLAACYLALVITVQYYLWPQGLIRQPGPLLSPSPWTSVFSVFPTICFGFQCHEAAVSIYCSMQNQSLPHWTLVSVLSLMACCLVYTLTGVYGFLTFGTEVSADILMSYPGNDTAIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWKKSYWATQGSPVLADPSGPWVRLPLTFLWVAVTLAMALFLPDLSEIIGVIGGLSAFFIFIFPGLCLISAVDTEPIGPRVKSRTTGSHGYHHEQFEEAGTDINRIGVVLPRRYCCVVWCEAQDCG", "length": 446 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5HZH7-1", "protein_name": "Solute carrier family 38 member 8", "gene_name": "Slc38a8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGQPRGSRGPLEKPLPAATHPTLSSLGAVFILLKSALGAGLLNFPWAFYKAGGMLPTFLVALVSLVFLISGLVILGYAASVSGQTTYQGVVRELCGPAMGKLCEICFLTNLLMISVAFLRVIGDQLEKLCDSLLPDAPQPWYAAQNFTLPLISMLVIFPLSALREIALQKYTSILGTLAACYLALVITVQYYLWPQGLIRQPGPLLSPSPWTSVFSVFPTICFGFQCHEAAVSIYCSMWNQSLSHWTLVSVLSLLACCLVYTLTGVYGFLTFGPEVSADILMSYPGNDTAIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWKKSYWATRGPPVLADPSGPWVRLPLTFLWVVVTLTMALFLPDLSEIISIIGGVSSFFIFIFPGLCLICAVDTEPMGPRVKCCLEAWGILSVLVGTFIFGQSTAVAMVELL", "length": 432 }, "evidence": [ { "id": "E1BDA4", "url": "https://omabrowser.org/oma/group/E1BDA4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-amino acid transmembrane transporter activity", "id": "GO:0015179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015179", "evidence": [ { "database": "UniProtKB", "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "amino acid transmembrane transport", "id": "GO:0003333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003333", "evidence": [ { "database": "UniProtKB", "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "E1BDA4", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 435, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDA4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA4" }, { "id": "PF01490", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid transporter transmembrane", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 428, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDD1-1", "uniprot_ac": "E1BDD1", "uniprot_id": "E1BDD1_BOVIN", "mass": { "chemical_mass": 67235.0, "monoisotopic_mass": 67235.0 }, "refseq": { "ac": "XP_024848168", "name": "probable methyltransferase-like protein 25 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848168" }, "gene_names": [ { "name": "METTL25", "type": "recommended", "evidence": [ { "id": "E1BDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD1" } ] }, { "name": "METTL25", "type": "synonym", "evidence": [ { "id": "XP_024848168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848168" } ] } ], "protein_names": [ { "name": "Methyltransferase like 25", "type": "synonym", "evidence": [ { "id": "E1BDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD1/entry#names_and_taxonomy" } ] }, { "name": "probable methyltransferase-like protein 25 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024848168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848168" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDD1", "url": "https://www.uniprot.org/uniprotkb/E1BDD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL25", "url": "https://www.uniprot.org/uniprotkb/E1BDD1", "locus": { "chromosome": "5", "start_pos": 12015445, "end_pos": 11908770, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008382", "url": "https://www.ensembl.org/id/ENSBTAG00000008382" } ] } } ], "crossref": [ { "id": "E1BDD1", "url": "https://alphafold.ebi.ac.uk/entry/E1BDD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513885", "url": "https://www.ncbi.nlm.nih.gov/gene/513885", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513885", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513885", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12496", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12496", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12496:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12496:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848168", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848168", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDD1", "url": "https://www.uniprot.org/uniprotkb/E1BDD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASGQLPVTQDLSTLHAKLQKLLRFLREALPISNAHTVDFYTESVWEKLVDLPPETVLSALRTSAAASEACPLEEAGRMSDVTDFPKIFCETSQKLVNVEAFALAAKYYSVQNLGICTSFDQLLVALHGNQKQKTDENVKLDEFMNLKKSHEVQAMSELISSIAEYCGIKQIIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTRGAEERNRKLKKHWKVYGRRSKPDVSGLALQTTKERKVQDETKADIEGICNSSTASQEKPPASDFLSEFSGSVISDIRRQMENLKVYSHREENLCFENAFSLRDLLPVNAIEPNSSSQIPKRKMSEASKERRKITLKSNESNIYSPLTSIITADSELHDIIKDLEDCLMVGLHTCGDLAPNTLRIFTSKSEVKGVCSVGCCYHLLSEEFENLHKEYTQERRGFPMCHYLKEERWCCGRNARMSACLALERVAVGQGLPTESLFYRAILQDIIKECYGITKCDRHVGKIYSKSSSFPDYVRKSLKKLGLDESKLPEKIIMDYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQDDIMWSALVRLFDPVKSPRCYAIIALKKQQ", "length": 594, "header": "tr|E1BDD1-1|E1BDD1_BOVIN Isoform 1 of Methyltransferase like 25 OS=Bos taurus OX=9913 GN=METTL25 PE=4 SV=4 CANONICAL=E1BDD1-1" }, "isoforms": [ { "isoform_ac": "E1BDD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD1/entry#E1BDD1-1", "sequence": { "sequence": "MAASGQLPVTQDLSTLHAKLQKLLRFLREALPISNAHTVDFYTESVWEKLVDLPPETVLSALRTSAAASEACPLEEAGRMSDVTDFPKIFCETSQKLVNVEAFALAAKYYSVQNLGICTSFDQLLVALHGNQKQKTDENVKLDEFMNLKKSHEVQAMSELISSIAEYCGIKQIIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTRGAEERNRKLKKHWKVYGRRSKPDVSGLALQTTKERKVQDETKADIEGICNSSTASQEKPPASDFLSEFSGSVISDIRRQMENLKVYSHREENLCFENAFSLRDLLPVNAIEPNSSSQIPKRKMSEASKERRKITLKSNESNIYSPLTSIITADSELHDIIKDLEDCLMVGLHTCGDLAPNTLRIFTSKSEVKGVCSVGCCYHLLSEEFENLHKEYTQERRGFPMCHYLKEERWCCGRNARMSACLALERVAVGQGLPTESLFYRAILQDIIKECYGITKCDRHVGKIYSKSSSFPDYVRKSLKKLGLDESKLPEKIIMDYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQDDIMWSALVRLFDPVKSPRCYAIIALKKQQ", "length": 594, "header": "tr|E1BDD1-1|E1BDD1_BOVIN Isoform 1 of Methyltransferase like 25 OS=Bos taurus OX=9913 GN=METTL25 PE=4 SV=4 CANONICAL=E1BDD1-1" }, "locus": { "chromosome": "5", "start_pos": 12015426, "end_pos": 11908969, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011034.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011034.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011034.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011034.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513885", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513885", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 594, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDD1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD1" }, { "id": "PF13679", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13679" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 410, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 342, "end_pos": 344 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDD7-1", "uniprot_ac": "E1BDD7", "uniprot_id": "E1BDD7_BOVIN", "mass": { "chemical_mass": 104963.0, "monoisotopic_mass": 104963.0 }, "refseq": { "ac": "NP_001178468", "name": "epithelial cell-transforming sequence 2 oncogene-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178468" }, "gene_names": [ { "name": "ECT2L", "type": "recommended", "evidence": [ { "id": "E1BDD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD7" } ] }, { "name": "ECT2L", "type": "synonym", "evidence": [ { "id": "NP_001178468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178468" } ] } ], "protein_names": [ { "name": "Epithelial cell transforming 2 like", "type": "synonym", "evidence": [ { "id": "E1BDD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD7/entry#names_and_taxonomy" } ] }, { "name": "epithelial cell transforming sequence 2 oncogene-like", "type": "synonym", "evidence": [ { "id": "NP_001178468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178468" } ] }, { "name": "epithelial cell-transforming sequence 2 oncogene-like", "type": "synonym", "evidence": [ { "id": "NP_001178468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178468" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDD7", "url": "https://www.uniprot.org/uniprotkb/E1BDD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ECT2L", "url": "https://www.uniprot.org/uniprotkb/E1BDD7", "locus": { "chromosome": "9", "start_pos": 76637327, "end_pos": 76575434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027312", "url": "https://www.ensembl.org/id/ENSBTAG00000027312" } ] } } ], "crossref": [ { "id": "E1BDD7", "url": "https://alphafold.ebi.ac.uk/entry/E1BDD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22173", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22173", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100141063", "url": "https://www.ncbi.nlm.nih.gov/gene/100141063", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025592", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025592", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100141063", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100141063", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BDD7", "url": "https://www.orthodb.org/?gene=E1BDD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46857:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46857:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178468", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDD7", "url": "https://www.uniprot.org/uniprotkb/E1BDD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFTIFLRCTKSQLRVIQDWFSERMQVAKVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCIKFGWFLPYTPTDNEYGAWKHHYIACVSNLDWLTPREAAAVYGTLNEPKTEDEELQERQRERCLRKIIWEKIALHKKELFKVRPPWVSGTHCSRLFKSKCQPRLSQTARDRVELHETLEKQLVLSSLESLPKRSNISGRHSYPLLSKKSWRGVYKNDSGSSNALQPHFILISSRIPAYEMVANSVRAGIISVVYEHSGLTLETLLYLIEKALDGQMAQSVGIFSDGDSREINLLQGYKIGIKNLLRPEVRDFWEKLGSYVAPEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTLFTAPTGIATGSYQHLLSDWLGRQWETAPPSIYFSESKLQTWSSLTDFLEDTLKSVRKQLSPLFKELQKNISGRMIGQFVFDTMSVANILNNQEIIQALADGLIELSKENSERDVIEDNPQDTKPSLSKNDPNFELLVKLERKLQLDSAEKRTRVVRELLQSERKYVQMLEIVRDVYVRPLRAALSSNRAILSAANIQIMFSDILQILCLNRRFLDDLRDRLQEWGPAHCVGEIFIKFGSQLNTYTNFFNNYPVVLKTIEKCREMIPAFRAFLKRHDKTIVTKMLSLPELLLYPSRRFEEYIHLLYALRLHTPAEHIDRGNLTIAIDQMKNYKGYIDQMKRNISMKDHLLDIQRLIWGCPTLSEANRYLIRVQDVAQLHCCDEDISFYLRLYEHTCDLSLFLFNDALLVSSRGISHTPFEKTSKSTYQFIASVALHRLIIEDIPDSKFIKNAFILQGPKHEWICATEVEDDKFLWLSVLQNAIKSSMEK", "length": 905, "header": "tr|E1BDD7-1|E1BDD7_BOVIN Isoform 1 of Epithelial cell transforming 2 like OS=Bos taurus OX=9913 GN=ECT2L PE=4 SV=2 CANONICAL=E1BDD7-1" }, "isoforms": [ { "isoform_ac": "E1BDD7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD7/entry#E1BDD7-1", "sequence": { "sequence": "MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFTIFLRCTKSQLRVIQDWFSERMQVAKVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCIKFGWFLPYTPTDNEYGAWKHHYIACVSNLDWLTPREAAAVYGTLNEPKTEDEELQERQRERCLRKIIWEKIALHKKELFKVRPPWVSGTHCSRLFKSKCQPRLSQTARDRVELHETLEKQLVLSSLESLPKRSNISGRHSYPLLSKKSWRGVYKNDSGSSNALQPHFILISSRIPAYEMVANSVRAGIISVVYEHSGLTLETLLYLIEKALDGQMAQSVGIFSDGDSREINLLQGYKIGIKNLLRPEVRDFWEKLGSYVAPEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTLFTAPTGIATGSYQHLLSDWLGRQWETAPPSIYFSESKLQTWSSLTDFLEDTLKSVRKQLSPLFKELQKNISGRMIGQFVFDTMSVANILNNQEIIQALADGLIELSKENSERDVIEDNPQDTKPSLSKNDPNFELLVKLERKLQLDSAEKRTRVVRELLQSERKYVQMLEIVRDVYVRPLRAALSSNRAILSAANIQIMFSDILQILCLNRRFLDDLRDRLQEWGPAHCVGEIFIKFGSQLNTYTNFFNNYPVVLKTIEKCREMIPAFRAFLKRHDKTIVTKMLSLPELLLYPSRRFEEYIHLLYALRLHTPAEHIDRGNLTIAIDQMKNYKGYIDQMKRNISMKDHLLDIQRLIWGCPTLSEANRYLIRVQDVAQLHCCDEDISFYLRLYEHTCDLSLFLFNDALLVSSRGISHTPFEKTSKSTYQFIASVALHRLIIEDIPDSKFIKNAFILQGPKHEWICATEVEDDKFLWLSVLQNAIKSSMEK", "length": 905, "header": "tr|E1BDD7-1|E1BDD7_BOVIN Isoform 1 of Epithelial cell transforming 2 like OS=Bos taurus OX=9913 GN=ECT2L PE=4 SV=2 CANONICAL=E1BDD7-1" }, "locus": { "chromosome": "9", "start_pos": 76637135, "end_pos": 76575434, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039145.4", "url": "https://www.ensembl.org/id/ENSBTAT00000039145.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038945.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038945.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100141063", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100141063", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1BDD7", "url": "https://www.uniprot.org/uniprotkb/E1BDD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 737, "end_pos": 739, "annotation": "n_glycosylation_sequon" }, { "start_pos": 758, "end_pos": 760, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 905, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDD7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD7" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 567, "end_pos": 755, "start_aa": "Lys", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 737, "end_pos": 739 }, { "start_pos": 758, "end_pos": 760 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDE1-1", "uniprot_ac": "E1BDE1", "uniprot_id": "E1BDE1_BOVIN", "mass": { "chemical_mass": 56904.0, "monoisotopic_mass": 56904.0 }, "refseq": {}, "gene_names": [ { "name": "SAXO5", "type": "recommended", "evidence": [ { "id": "E1BDE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE1" } ] }, { "name": "TEX45", "type": "synonym", "evidence": [ { "id": "E1BDE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE1" } ] } ], "protein_names": [ { "name": "Stabilizer of axonemal microtubules 5", "type": "synonym", "evidence": [ { "id": "E1BDE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDE1", "url": "https://www.uniprot.org/uniprotkb/E1BDE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAXO5", "url": "https://www.uniprot.org/uniprotkb/E1BDE1", "locus": { "chromosome": "7", "start_pos": 16374004, "end_pos": 16369084, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002629", "url": "https://www.ensembl.org/id/ENSBTAG00000002629" } ] } } ], "crossref": [ { "id": "E1BDE1", "url": "https://alphafold.ebi.ac.uk/entry/E1BDE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002629", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002629", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDE1", "url": "https://www.orthodb.org/?gene=E1BDE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34828", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34828", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34828:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34828:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BDE1", "url": "https://www.uniprot.org/uniprotkb/E1BDE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDE1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGALLPCPVSRLDFLKASHFALGPDPRLHADAKQSTSHRDFPAYSSAIRGPLCPPPPCASLFQKDARWAGQERLSETRCAYEPPPPMLLREQERELARERTLAMQASHLHVHAEARARTGLSTARGDYGWPEPPERAREQIRGARLIFDRDSLPSGDPDKLRIPSTTYREFFPLHDLCLKPREPACRLCGPNPLQWEHKRQDDSTSYQRQFQALPGPPALPCKRASSSIELGDFKIGYRPMCTEQKQAYGPPDLPPDRYDKAQASAHIHCVNIRPGDGLFHDRTTKGEHFYAREPEPFLLHHDQTPESHILEGNGCPGPGSLTTSTHFFYRQPLRTSEPASRHVPHETLQSHITLGEPSLLGQFFQTSMGTDYLPPGMPKPPKAPNLHLQRSNLPEGTGDLDFLTMNQKMLKPHGIAPASVTKELLQRCKYSHLEPPLGQQRFFSTLNKDEFTFKYQGPAVLRWDDFQESHLPLGSLHQWGCRARKVDPRAPQTPIYPCPSQQ", "length": 505, "header": "tr|E1BDE1-1|E1BDE1_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 5 OS=Bos taurus OX=9913 GN=SAXO5 PE=4 SV=3 CANONICAL=E1BDE1-1" }, "isoforms": [ { "isoform_ac": "E1BDE1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE1/entry#E1BDE1-1", "sequence": { "sequence": "MAAGALLPCPVSRLDFLKASHFALGPDPRLHADAKQSTSHRDFPAYSSAIRGPLCPPPPCASLFQKDARWAGQERLSETRCAYEPPPPMLLREQERELARERTLAMQASHLHVHAEARARTGLSTARGDYGWPEPPERAREQIRGARLIFDRDSLPSGDPDKLRIPSTTYREFFPLHDLCLKPREPACRLCGPNPLQWEHKRQDDSTSYQRQFQALPGPPALPCKRASSSIELGDFKIGYRPMCTEQKQAYGPPDLPPDRYDKAQASAHIHCVNIRPGDGLFHDRTTKGEHFYAREPEPFLLHHDQTPESHILEGNGCPGPGSLTTSTHFFYRQPLRTSEPASRHVPHETLQSHITLGEPSLLGQFFQTSMGTDYLPPGMPKPPKAPNLHLQRSNLPEGTGDLDFLTMNQKMLKPHGIAPASVTKELLQRCKYSHLEPPLGQQRFFSTLNKDEFTFKYQGPAVLRWDDFQESHLPLGSLHQWGCRARKVDPRAPQTPIYPCPSQQ", "length": 505, "header": "tr|E1BDE1-1|E1BDE1_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 5 OS=Bos taurus OX=9913 GN=SAXO5 PE=4 SV=3 CANONICAL=E1BDE1-1" }, "locus": { "chromosome": "7", "start_pos": 16373985, "end_pos": 16369084, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003404.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003404.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003404.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003404.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDE1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 505, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDE1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDE1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDE2-1", "uniprot_ac": "E1BDE2", "uniprot_id": "E1BDE2_BOVIN", "mass": { "chemical_mass": 64895.0, "monoisotopic_mass": 64895.0 }, "refseq": { "ac": "XP_010807520", "name": "piRNA biogenesis protein EXD1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807520" }, "gene_names": [ { "name": "EXD1", "type": "recommended", "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ] }, { "name": "EXD1", "type": "synonym", "evidence": [ { "id": "XP_010807520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807520" } ] } ], "protein_names": [ { "name": "piRNA biogenesis protein EXD1", "type": "recommended", "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2/entry#names_and_taxonomy" } ] }, { "name": "Exonuclease 3'-5' domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2/entry#names_and_taxonomy" } ] }, { "name": "Exonuclease 3'-5' domain-like-containing protein 1", "type": "synonym", "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2/entry#names_and_taxonomy" } ] }, { "name": "Inactive exonuclease EXD1", "type": "synonym", "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2/entry#names_and_taxonomy" } ] }, { "name": "piRNA biogenesis protein EXD1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010807520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807520" } ] } ], "function": [ { "annotation": "RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2#function" }, { "database": "UniProtKB", "id": "ARBA00057144", "url": "https://www.uniprot.org/uniprotkb/ARBA00057144#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXD1", "url": "https://www.uniprot.org/uniprotkb/E1BDE2", "locus": { "chromosome": "10", "start_pos": 36677984, "end_pos": 36719945, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008363", "url": "https://www.ensembl.org/id/ENSBTAG00000008363" } ] } } ], "crossref": [ { "id": "E1BDE2", "url": "https://alphafold.ebi.ac.uk/entry/E1BDE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008363", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008363", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617602", "url": "https://www.ncbi.nlm.nih.gov/gene/617602", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617602", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617602", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BDE2", "url": "https://www.orthodb.org/?gene=E1BDE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46628:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46628:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010807520", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807520", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDE2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLSSDYHFLNQILWRRVRLTLVCGIFEGVLQHVDPDKIVVLKKVKNVETGLSVPGVKMFFGHEIVNVELLDEVEQGAVREKASSVSLNTERTKMDTIKDEDLNVRKPASPAPEVPITSLLNDFKYSPSEEEEVTYTVIDQFQQKFGAAMLHIKKQSVLSVAAEGANVCRHGKLCWLQVATNSRVYLFDIFLLGSRAFNNGLQMVLEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQFSVETGGFLPNCISTLQESLIRHLKIAPKHLSFLEVRQKWIRENPELWFTRPLSPSLLKILALEATYLLPLRLVLLDEMMSDLTTLVDGYLNTYREGSADRLGGMEPTCMELPEELLQLQDFQKQRRERAAKEYRVNAQGLLIRTVLHPKKSVTETAGKEGKVRGFLLCKNSTQDKAPNVTSREDVDLLKEESKSRQTTVEPQYLPLTKEDASEDSSYNLNYPESEGVKDQRITQKKHLKIPKQEFQTSLSLKEEIEQLLMVENKEDLKGTKQDVSVSPSLPQETRVSPSDIFHPFRKAVLPTLPPCPALEKTDSWLNPDSPNLP", "length": 571, "header": "tr|E1BDE2-1|E1BDE2_BOVIN Isoform 1 of piRNA biogenesis protein EXD1 OS=Bos taurus OX=9913 GN=EXD1 PE=3 SV=3 CANONICAL=E1BDE2-1" }, "isoforms": [ { "isoform_ac": "E1BDE2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE2/entry#E1BDE2-1", "sequence": { "sequence": "MDLSSDYHFLNQILWRRVRLTLVCGIFEGVLQHVDPDKIVVLKKVKNVETGLSVPGVKMFFGHEIVNVELLDEVEQGAVREKASSVSLNTERTKMDTIKDEDLNVRKPASPAPEVPITSLLNDFKYSPSEEEEVTYTVIDQFQQKFGAAMLHIKKQSVLSVAAEGANVCRHGKLCWLQVATNSRVYLFDIFLLGSRAFNNGLQMVLEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQFSVETGGFLPNCISTLQESLIRHLKIAPKHLSFLEVRQKWIRENPELWFTRPLSPSLLKILALEATYLLPLRLVLLDEMMSDLTTLVDGYLNTYREGSADRLGGMEPTCMELPEELLQLQDFQKQRRERAAKEYRVNAQGLLIRTVLHPKKSVTETAGKEGKVRGFLLCKNSTQDKAPNVTSREDVDLLKEESKSRQTTVEPQYLPLTKEDASEDSSYNLNYPESEGVKDQRITQKKHLKIPKQEFQTSLSLKEEIEQLLMVENKEDLKGTKQDVSVSPSLPQETRVSPSDIFHPFRKAVLPTLPPCPALEKTDSWLNPDSPNLP", "length": 571, "header": "tr|E1BDE2-1|E1BDE2_BOVIN Isoform 1 of piRNA biogenesis protein EXD1 OS=Bos taurus OX=9913 GN=EXD1 PE=3 SV=3 CANONICAL=E1BDE2-1" }, "locus": { "chromosome": "10", "start_pos": 36717174, "end_pos": 36678450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011011.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011011.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011011.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011011.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617602", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617602", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" }, { "name": "3'-5' exonuclease activity", "id": "GO:0008408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008408", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" }, { "name": "PET complex", "id": "GO:1990923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990923", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "E1BDE2", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 571, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDE2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE2" }, { "id": "SM00474", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00474" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3'-5' exonuclease", "eco_id": "ECO_0000259", "start_pos": 135, "end_pos": 326, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 417, "end_pos": 419 }, { "start_pos": 425, "end_pos": 427 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDF5-1", "uniprot_ac": "E1BDF5", "uniprot_id": "E1BDF5_BOVIN", "mass": { "chemical_mass": 48035.0, "monoisotopic_mass": 48035.0 }, "refseq": {}, "gene_names": [ { "name": "SERPINB12", "type": "recommended", "evidence": [ { "id": "E1BDF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" } ] } ], "protein_names": [ { "name": "Serpin family B member 12", "type": "synonym", "evidence": [ { "id": "E1BDF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDF5", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINB12", "url": "https://www.uniprot.org/uniprotkb/E1BDF5", "locus": { "chromosome": "24", "start_pos": 61817474, "end_pos": 61793174, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035171", "url": "https://www.ensembl.org/id/ENSBTAG00000035171" } ] } } ], "crossref": [ { "id": "E1BDF5", "url": "https://alphafold.ebi.ac.uk/entry/E1BDF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035171", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035171", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19571", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19571", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CYFGKLL", "url": "https://omabrowser.org/oma/group/CYFGKLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF125", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF125", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BDF5", "url": "https://www.uniprot.org/uniprotkb/E1BDF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSLIAANTKFCFDLFQKISTDDCRKNIFFCPLSLSAALGMVRLGARSGSARQIDQVLHFNEFSQNKGNEPDPCLKKAEQEVPADSNLEGQKEVTGSLTLQTESSKDESGLLSCYFGQLLSKLARIKVDYTLSIANRLYGEREFPICPEYLDGVIQFYHTTVESVDFRKDSEKSRQEINFWVESQSQGKIKELFSKDSINSETVLVLVNAVYFKAKWEKYFDCENTVDAVFSLSESEKKNVKMMNQNGLFRIGFVDELKAQILELPYTKGKLDMVVLLPSGSADNLKALEELERNITYEKLVSWSSSENMSEKRVAVSFPRFTLEDSYDLNPILQDMGITDIFDETKADLSGISPRPSLYLSKVVHKTFLEVDENGTQAVAASGVVGMEKSSPSWETFNANRPFLFFIRHNKTQTILFYGRVCSP", "length": 425, "header": "tr|E1BDF5-1|E1BDF5_BOVIN Isoform 1 of Serpin family B member 12 OS=Bos taurus OX=9913 GN=SERPINB12 PE=3 SV=3 CANONICAL=E1BDF5-1" }, "isoforms": [ { "isoform_ac": "E1BDF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF5/entry#E1BDF5-1", "sequence": { "sequence": "MDSLIAANTKFCFDLFQKISTDDCRKNIFFCPLSLSAALGMVRLGARSGSARQIDQVLHFNEFSQNKGNEPDPCLKKAEQEVPADSNLEGQKEVTGSLTLQTESSKDESGLLSCYFGQLLSKLARIKVDYTLSIANRLYGEREFPICPEYLDGVIQFYHTTVESVDFRKDSEKSRQEINFWVESQSQGKIKELFSKDSINSETVLVLVNAVYFKAKWEKYFDCENTVDAVFSLSESEKKNVKMMNQNGLFRIGFVDELKAQILELPYTKGKLDMVVLLPSGSADNLKALEELERNITYEKLVSWSSSENMSEKRVAVSFPRFTLEDSYDLNPILQDMGITDIFDETKADLSGISPRPSLYLSKVVHKTFLEVDENGTQAVAASGVVGMEKSSPSWETFNANRPFLFFIRHNKTQTILFYGRVCSP", "length": 425, "header": "tr|E1BDF5-1|E1BDF5_BOVIN Isoform 1 of Serpin family B member 12 OS=Bos taurus OX=9913 GN=SERPINB12 PE=3 SV=3 CANONICAL=E1BDF5-1" }, "locus": { "chromosome": "24", "start_pos": 61816470, "end_pos": 61806573, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049662.5", "url": "https://www.ensembl.org/id/ENSBTAT00000049662.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046522.3", "url": "https://www.ensembl.org/id/ENSBTAP00000046522.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZPF9-1", "protein_name": "Serpin B12", "gene_name": "Serpinb12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSLVAANNKFCFDFFQEISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAQQIDEVLHFNELPKDERKEPSEPSSKSKASDSSLEGQKQTTASQGQQGESTNEHRLLGCHFGKLLSRIDRDKAHYTLSMANRLYGEQEFPICPEYSDDITEFYHTTIESVDFQKDTEKSREEINFWVESQSQGKIKELFDKEAIDNSTVLVLVNAVYFKAKWEKEFDSENTVDAPFCLSENEKKTVKMMNQKGQFRIGFIEELQAQILEMKYTTGKLSMLVLLPSSSEDNVKSLQELEKKINHEKLLAWSNPENMSEKPVAISFPQFIMEDSYDLNSVLQDMGIRDVFDGTKADLTGISKSPSLHLSKVVHKTFVEVDEMGTQAAAASGAVVAEKALPSRVEFNANRPFLFFIRHNGTQSLLFCGRVYSP", "length": 421 }, "evidence": [ { "id": "E1BDF5", "url": "https://omabrowser.org/oma/group/E1BDF5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96P63-1", "protein_name": "Serpin B12", "gene_name": "SERPINB12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPCLKSNKQKAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP", "length": 405 }, "evidence": [ { "id": "E1BDF5", "url": "https://omabrowser.org/oma/group/E1BDF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7P9-1", "protein_name": "Serpin B12", "gene_name": "Serpinb12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSLTAANNKFCFDFFREISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAHQIDEALHFNELSKDEHKEPNDPSPQSESKASDSSLEGQKQTSASQDQQGESTNDHQLLGCHFGKLLSRIDRDKSYYTLSMANRLYGEQEFPICSEYSDDVTEFFHTTVESVDFQKDSEKSRQEINFWVESQSQGKIKELFGKEAIDNSTVLVLVNAVYFKAKWEREFNSENTVDASFCLNENEKKTVKMMNQKGKFRIGFIDELQAQILEMKYAMGKLSMLVLLPSCSEDNVNSLQELEKKINHEKLLAWSSSENLSEKPVAISFPQFNLEDSYDLKSILQDMGIKDVFDETKADLTGISKSPNLYLSKIVHKTFVEVDEMGTQAAAASGVVAAEKALPSWVEFNANHPFLFFIRHNPTQSLLFCGRVYCP", "length": 423 }, "evidence": [ { "id": "E1BDF5", "url": "https://omabrowser.org/oma/group/E1BDF5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M1T7-1", "protein_name": "Serpin-Z4", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MELGKSMENQTDVMVLLAKHVIPTVANGSNLVFSPMSINVLLCLIAAGSNCVTKEQILSFIMLPSSDYLNAVLAKTVSVALNDGMERSDLHLSTAYGVWIDKSLSFKPSFKDLLENSYNATCNQVDFATKPAEVINEVNAWAEVHTNGLIKEILSDDSIKTIRESMLILANAVYFKGAWSKKFDAKLTKSYDFHLLDGTMVKVPFMTNYKKQYLEYYDGFKVLRLPYVEDQRQFAMYIYLPNDRDGLPTLLEEISSKPRFLDNHIPRQRILTEAFKIPKFKFSFEFKASDVLKEMGLTLPFTHGSLTEMVESPSIPENLCVAENLFVSNVFHKACIEVDEEGTEAAAVSVASMTKDMLLMGDFVADHPFLFTVREEKSGVILFMGQVLDPSIH", "length": 393 }, "evidence": [ { "id": "E1BDF5", "url": "https://omabrowser.org/oma/group/E1BDF5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BDF5", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BDF5", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "E1BDF5", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDF5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 425, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDF5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDF5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF5" }, { "id": "SM00093", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serpin", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 425, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 309, "end_pos": 311 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 411, "end_pos": 413 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDH2-1", "uniprot_ac": "E1BDH2", "uniprot_id": "E1BDH2_BOVIN", "mass": { "chemical_mass": 51467.0, "monoisotopic_mass": 51467.0 }, "refseq": { "ac": "NP_001192570", "name": "putative protein MSS51 homolog, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570" }, "gene_names": [ { "name": "MSS51", "type": "recommended", "evidence": [ { "id": "E1BDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH2" } ] }, { "name": "MSS51", "type": "synonym", "evidence": [ { "id": "NP_001192570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570" } ] }, { "name": "ZMYND17", "type": "synonym", "evidence": [ { "id": "NP_001192570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570" } ] } ], "protein_names": [ { "name": "MSS51 mitochondrial translational activator", "type": "synonym", "evidence": [ { "id": "E1BDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH2/entry#names_and_taxonomy" } ] }, { "name": "putative protein MSS51 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001192570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570" } ] }, { "name": "zinc finger, MYND-type containing 17", "type": "synonym", "evidence": [ { "id": "NP_001192570", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDH2", "url": "https://www.uniprot.org/uniprotkb/E1BDH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSS51", "url": "https://www.uniprot.org/uniprotkb/E1BDH2", "locus": { "chromosome": "28", "start_pos": 29413416, "end_pos": 29417580, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020219", "url": "https://www.ensembl.org/id/ENSBTAG00000020219" } ] } } ], "crossref": [ { "id": "E1BDH2", "url": "https://alphafold.ebi.ac.uk/entry/E1BDH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508577", "url": "https://www.ncbi.nlm.nih.gov/gene/508577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DELGHMF", "url": "https://omabrowser.org/oma/group/DELGHMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDH2", "url": "https://www.orthodb.org/?gene=E1BDH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46920:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46920:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192570", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDH2", "url": "https://www.uniprot.org/uniprotkb/E1BDH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPRSRRRRHKKSPSSVAPVVETPPTVVAPVPLILTKPGPSIDKLGFSSLEDNVPGLSQLILQKLNMKSYEEYKLVLDGGTPVSGFGYRCLEEMFQKMEDTFRFCAYCKALPRGLSDSKVLRHCKRCRNVYYCGPECQKSDWPTHRKVCQELRLVAVDRLMEWLLVTGDFVLPSGPWSWLTEVVQGWDTWFSMRRLQLDDTMDAVLDSQAMTTLWASVRRPRPDPDVLKGSLKRLLTDVLSRPLTLGFGLRALGINVGKVGGSTVHVVGASHAETFLTRPGDYDELGYMFPGHLGLHVIMVGVDVAAGFSQSTSASLLEPGTVQLSSHRGLYHDFWEEQIETGQIAHPDLVVAFHPGFHASPDLMEAWLPTLLLLRDYGIPTMITVYSHQELAASLQILVDLDTHITAYGANPFASLKPEQVYSNPNKQPVYCSAYYIMFLGSSCQLDKRQLEEKVNDRV", "length": 460, "header": "tr|E1BDH2-1|E1BDH2_BOVIN Isoform 1 of MSS51 mitochondrial translational activator OS=Bos taurus OX=9913 GN=MSS51 PE=4 SV=1 CANONICAL=E1BDH2-1" }, "isoforms": [ { "isoform_ac": "E1BDH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDH2/entry#E1BDH2-1", "sequence": { "sequence": "MAPRSRRRRHKKSPSSVAPVVETPPTVVAPVPLILTKPGPSIDKLGFSSLEDNVPGLSQLILQKLNMKSYEEYKLVLDGGTPVSGFGYRCLEEMFQKMEDTFRFCAYCKALPRGLSDSKVLRHCKRCRNVYYCGPECQKSDWPTHRKVCQELRLVAVDRLMEWLLVTGDFVLPSGPWSWLTEVVQGWDTWFSMRRLQLDDTMDAVLDSQAMTTLWASVRRPRPDPDVLKGSLKRLLTDVLSRPLTLGFGLRALGINVGKVGGSTVHVVGASHAETFLTRPGDYDELGYMFPGHLGLHVIMVGVDVAAGFSQSTSASLLEPGTVQLSSHRGLYHDFWEEQIETGQIAHPDLVVAFHPGFHASPDLMEAWLPTLLLLRDYGIPTMITVYSHQELAASLQILVDLDTHITAYGANPFASLKPEQVYSNPNKQPVYCSAYYIMFLGSSCQLDKRQLEEKVNDRV", "length": 460, "header": "tr|E1BDH2-1|E1BDH2_BOVIN Isoform 1 of MSS51 mitochondrial translational activator OS=Bos taurus OX=9913 GN=MSS51 PE=4 SV=1 CANONICAL=E1BDH2-1" }, "locus": { "chromosome": "28", "start_pos": 29417156, "end_pos": 29414134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026928.4", "url": "https://www.ensembl.org/id/ENSBTAT00000026928.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026928.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026928.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508577", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D2BUE1-1", "protein_name": "MSS51 mitochondrial translational activator", "gene_name": "MSS51", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPRSRRRRHKKPPSSVAPVVVTPPAIVTPMPLARSEPGPSIDMLGFFSLEDNVPGLSHLILQKLNMKSYEEYKLVLDGGTPVSGFGYRCLQEMFQKMEDTFRFCAHCRALPSGLSDSKVLRHCKRCRNVYYCGPECQRSDWPAHRKVCQELRLVAVDRFMEWLLVTGDFVPPSGPWSWPTEVVQGWDTWFSMRCLQLDATLDAVLSSQAMTTLWANVGRPRPDPGVLQGSLKRLLTDALSRPLTLGFGLRALGINVGKVGGSTVHVIGASHAETFLTRPGDYDELGYMFPGHLGFHIIMVGVDVAADFSQSPSASLPEPGTIQLSSHRGLYHDFWEEQVETGKIPHPDLVVAFHPGFHASADLMEAWLPTLLLLRDYEIPTMITVYSHQELAASLQILADLDTHITAYGANPFASLKPEQVYSNPNKQPVYCSTYYIMFLGSSCQLDKRQLEEKVDDGV", "length": 460 }, "evidence": [ { "id": "E1BDH2", "url": "https://omabrowser.org/oma/group/E1BDH2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZKV9-1", "protein_name": "Putative protein MSS51 homolog, mitochondrial", "gene_name": "Mss51", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPRSRRRKHKKPPPVTPMPDIPPTDVSAVRPALPEPGPSIDALGFIALDSDVPGLPQRILQRLNMKSYEEYKLVIDGGTPVPSFGFRCQQEMFQRMEDTFRFCAYCKALPHGLSSCKVLRHCKRCRNVYYCDAECQRSDWPAHRKVCGELRLVAVDRVMEWLLVTGDFVLPSGPWPWLPEEIQNWDTWFSMRGLQLESTLNALLGSHAMTMLWASLGRPRPDPDVLHGSLKRLMTDVLSRPLTLGLGIRTLAIDVGKTGGSTLHVVGASHVETFLIRSGDYDELGYMFPENLGFRVIMVGVDVSADLLQSSSSLPLEPGTVQLSGHRALYHDFWEEQIETGNLAHPDLVAAFHPGFHASPGLMEAWLPTLLLLRDYEIPTLITVYSQQELEASLQVLVNLDTHIIACGANPFASLKPEQVYSKPNKQPVYSSAYYIVFRGCSSCQLDKQQVEEEPDEFSVVESNPN", "length": 467 }, "evidence": [ { "id": "E1BDH2", "url": "https://omabrowser.org/oma/group/E1BDH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4VC12-1", "protein_name": "Putative protein MSS51 homolog, mitochondrial", "gene_name": "MSS51", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPRSRRRRHKKPPSSVAPIIMAPTTIVTPVPLTPSKPGPSIDTLGFFSLDDNVPGLSQLILQKLNMKSYEEYKLVVDGGTPVSGFGFRCPQEMFQRMEDTFRFCAHCRALPSGLSDSKVLRHCKRCRNVYYCGPECQKSDWPAHRRVCQELRLVAVDRLMEWLLVTGDFVLPSGPWPWPPEAVQDWDSWFSMKGLHLDATLDAVLVSHAVTTLWASVGRPRPDPDVLQGSLKRLLTDVLSRPLTLGLGLRALGIDVRRTGGSTVHVVGASHVETFLTRPGDYDELGYMFPGHLGLRVVMVGVDVATGFSQSTSTSPLEPGTIQLSAHRGLYHDFWEEQVETGQTHHPDLVAAFHPGFHSSPDLMEAWLPTLLLLRDYKIPTLITVYSHQELVSSLQILVELDTHITAFGSNPFMSLKPEQVYSSPNKQPVYCSAYYIMFLGSSCQLDNRQLEEKVDGGI", "length": 460 }, "evidence": [ { "id": "E1BDH2", "url": "https://omabrowser.org/oma/group/E1BDH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D5Z5-1", "protein_name": "Putative protein MSS51 homolog, mitochondrial", "gene_name": "Mss51", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPRSRRRKHKKPPPVIPMIEIPPTEVSPVSPALSKPGPSIDALGFISLDNNVPGLSQLILQKLNMKNYEEYKLVINGGTPVSSFGFRCQQEMFQKMEDTFRFCAYCKVLPHGLSNCKVLRHCKRCRNVYYCDTECQRSDWPAHRKVCRELRLVAVDRVMEWLLVTGDFVLPSGPWPWLPEDIQNWDTWFSMRGLQLESTLNALLGSHSMTMLWASLGRPRPDPDVLHGSLKRLMTDVLSRPLTLGLGLRTVAIDVGKTGGSTLHVVGASHVETFLIRSGDYDELGYMFPEHLGFHVIMVGVDVATDLLQSSSSLSLEPGTIQLSGHRALYHDFWEEQIETGILAHPDLVAAFHPGFHASPGLMEAWLPTLLLLRDYEIPTLITVYSQQELEASLQILVNLDTHIIACGANPFASLKPEQVYSNPNKQPVYSSAYYIMFLGSSPAN", "length": 446 }, "evidence": [ { "id": "E1BDH2", "url": "https://omabrowser.org/oma/group/E1BDH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BDH2", "url": "https://www.uniprot.org/uniprotkb/E1BDH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDH2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 460, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDH2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDH2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH2" }, { "id": "PS50865", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MYND-type", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 149, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDL0-1", "uniprot_ac": "E1BDL0", "uniprot_id": "E1BDL0_BOVIN", "mass": { "chemical_mass": 84743.0, "monoisotopic_mass": 84743.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Protocadherin beta 15", "type": "synonym", "evidence": [ { "id": "E1BDL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BDL0", "locus": {} } ], "crossref": [ { "id": "E1BDL0", "url": "https://alphafold.ebi.ac.uk/entry/E1BDL0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAGVERFRQQRQVLILFLLLGVTFAGWESRRYSVMEEIESGSFVANLVKDLGLGVGELAAREARVVSEDNEPRLQLDLQTGKLTLNEKLDREEMCGPTDPCVMHFQVLLKKPLGVFRAELLVRDINDHAPEFPEREMTLKIPENSPPGTVFPLKKAQDLDVGNNNIQNYSISPNSYFHVSTRNRGDGRKYPELVLDRELDREKQALLRLTLTALDGGSPPRSGTTQVRILVLDINDNAPEFAQAHYQVQVLENSPVGALVVKVSARDLDTGTNGEVSYSLFYSSQEMSPTFELNSLSGEVRLIKKLDFETVSSYDLDIDAFDGGGLSGKCSVSIEVVDVNDNAPELTISSLTSPIPENSPETEVALFRIRDRDSGENGKMTCSIQDDLPFILKPSEENFYTLVTNGALDRESKAEYNVTITVTDLGTPRLKTEHNIIVLVSDVNDNAPAFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAAPADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRGGAASAGRCPVAEGHFPGHLVDVSGTGTLSQSYQYEVCLTGGTGTNEFKFLKPTFKFFLISN", "length": 779, "header": "tr|E1BDL0-1|E1BDL0_BOVIN Isoform 1 of Protocadherin beta 15 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BDL0-1" }, "isoforms": [ { "isoform_ac": "E1BDL0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL0/entry#E1BDL0-1", "sequence": { "sequence": "MEAGVERFRQQRQVLILFLLLGVTFAGWESRRYSVMEEIESGSFVANLVKDLGLGVGELAAREARVVSEDNEPRLQLDLQTGKLTLNEKLDREEMCGPTDPCVMHFQVLLKKPLGVFRAELLVRDINDHAPEFPEREMTLKIPENSPPGTVFPLKKAQDLDVGNNNIQNYSISPNSYFHVSTRNRGDGRKYPELVLDRELDREKQALLRLTLTALDGGSPPRSGTTQVRILVLDINDNAPEFAQAHYQVQVLENSPVGALVVKVSARDLDTGTNGEVSYSLFYSSQEMSPTFELNSLSGEVRLIKKLDFETVSSYDLDIDAFDGGGLSGKCSVSIEVVDVNDNAPELTISSLTSPIPENSPETEVALFRIRDRDSGENGKMTCSIQDDLPFILKPSEENFYTLVTNGALDRESKAEYNVTITVTDLGTPRLKTEHNIIVLVSDVNDNAPAFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAAPADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRGGAASAGRCPVAEGHFPGHLVDVSGTGTLSQSYQYEVCLTGGTGTNEFKFLKPTFKFFLISN", "length": 779, "header": "tr|E1BDL0-1|E1BDL0_BOVIN Isoform 1 of Protocadherin beta 15 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BDL0-1" }, "locus": { "chromosome": "7", "start_pos": 52347613, "end_pos": 52344267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009669.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009669.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009669.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009669.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 99, "start_aa": "Thr", "end_pos": 99, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr99", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "E1BDL0", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL0" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 133, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 99 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 567, "end_pos": 569 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDN0-1", "uniprot_ac": "E1BDN0", "uniprot_id": "E1BDN0_BOVIN", "mass": { "chemical_mass": 60731.0, "monoisotopic_mass": 60731.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "AKNA domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BDN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDN0", "url": "https://www.uniprot.org/uniprotkb/E1BDN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BDN0", "locus": {} } ], "crossref": [ { "id": "E1BDN0", "url": "https://alphafold.ebi.ac.uk/entry/E1BDN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007333", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007333", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21510", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21510", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21510:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21510:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BDN0", "url": "https://www.uniprot.org/uniprotkb/E1BDN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDKAYFLEDTTSKQQEDLPYDEGFSQVKLYHGYNLTSRYDILDVSNQMNLTEDESQEKATYRETCQEADMTMTLDKMTENAVSKTCDKENQCTIYLPISANQEDASKSNISDILLHHLCKEEFSKDQGINCETLPEISNNDSFDEAIIKNIIVWHVKNSWPTEQSSELTDLLNSKSDDENSNKPSCFLTMMEENTSDSDESMASGESNHEENSNFLSKIKSLCDKQKSCLWQTPQKQAEKESSGNKFKYGHSQVYYWFSNFSKVASKVKIPKNYTIDKPLITDPQASFSPKLRDKSAVGQDISESTSRSNYVEKQEQKWETTQPSQPVEMEPTVHIHQEHLTGIESEPSLSNLPSTSQEDPSLSSSYIFQKISQGKQMCQKLKEQTDQLKAKVQEFSKCIAQDSPYHFQRRRLVLEKLQGRLKLLEQEFLANKEKHLTLEEQVHEHESPAVKDFDPERKVEGEIFKLEMLLKDFKEKIYKSKRTSAVSLPVNSPINLDDLSFTSSPPLNEVIQQPTANFMPGKMVFMYV", "length": 529, "header": "tr|E1BDN0-1|E1BDN0_BOVIN Isoform 1 of AKNA domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=E1BDN0-1" }, "isoforms": [ { "isoform_ac": "E1BDN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN0/entry#E1BDN0-1", "sequence": { "sequence": "MDKAYFLEDTTSKQQEDLPYDEGFSQVKLYHGYNLTSRYDILDVSNQMNLTEDESQEKATYRETCQEADMTMTLDKMTENAVSKTCDKENQCTIYLPISANQEDASKSNISDILLHHLCKEEFSKDQGINCETLPEISNNDSFDEAIIKNIIVWHVKNSWPTEQSSELTDLLNSKSDDENSNKPSCFLTMMEENTSDSDESMASGESNHEENSNFLSKIKSLCDKQKSCLWQTPQKQAEKESSGNKFKYGHSQVYYWFSNFSKVASKVKIPKNYTIDKPLITDPQASFSPKLRDKSAVGQDISESTSRSNYVEKQEQKWETTQPSQPVEMEPTVHIHQEHLTGIESEPSLSNLPSTSQEDPSLSSSYIFQKISQGKQMCQKLKEQTDQLKAKVQEFSKCIAQDSPYHFQRRRLVLEKLQGRLKLLEQEFLANKEKHLTLEEQVHEHESPAVKDFDPERKVEGEIFKLEMLLKDFKEKIYKSKRTSAVSLPVNSPINLDDLSFTSSPPLNEVIQQPTANFMPGKMVFMYV", "length": 529, "header": "tr|E1BDN0-1|E1BDN0_BOVIN Isoform 1 of AKNA domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=E1BDN0-1" }, "locus": { "chromosome": "3", "start_pos": 34540555, "end_pos": 34517748, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009644.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009644.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009644.8", "url": "https://www.ensembl.org/id/ENSBTAP00000009644.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDN0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 529, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDN0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDN0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN0" }, { "id": "PF12443", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12443" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AKNA", "eco_id": "ECO_0000259", "start_pos": 326, "end_pos": 419, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 140, "end_pos": 142 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDN8-1", "uniprot_ac": "E1BDN8", "uniprot_id": "E1BDN8_BOVIN", "mass": { "chemical_mass": 72484.0, "monoisotopic_mass": 72484.0 }, "refseq": { "ac": "NP_001193066", "name": "splicing regulatory glutamine/lysine-rich protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066" }, "gene_names": [ { "name": "SREK1", "type": "recommended", "evidence": [ { "id": "E1BDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ] }, { "name": "SFRS12", "type": "synonym", "evidence": [ { "id": "NP_001193066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066" } ] }, { "name": "SREK1", "type": "synonym", "evidence": [ { "id": "NP_001193066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066" } ] } ], "protein_names": [ { "name": "Splicing regulatory glutamine/lysine-rich protein 1", "type": "recommended", "evidence": [ { "id": "E1BDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN8/entry#names_and_taxonomy" } ] }, { "name": "Serine/arginine-rich-splicing regulatory protein 86", "type": "synonym", "evidence": [ { "id": "E1BDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN8/entry#names_and_taxonomy" } ] }, { "name": "Splicing factor, arginine/serine-rich 12", "type": "synonym", "evidence": [ { "id": "E1BDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN8/entry#names_and_taxonomy" } ] }, { "name": "splicing factor, arginine/serine-rich 12", "type": "synonym", "evidence": [ { "id": "NP_001193066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066" } ] }, { "name": "splicing regulatory glutamine/lysine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001193066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066" } ] } ], "function": [ { "annotation": "Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8#function" }, { "database": "UniProtKB", "id": "ARBA00058989", "url": "https://www.uniprot.org/uniprotkb/ARBA00058989#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SREK1", "url": "https://www.uniprot.org/uniprotkb/E1BDN8", "locus": { "chromosome": "20", "start_pos": 13439033, "end_pos": 13483910, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007321", "url": "https://www.ensembl.org/id/ENSBTAG00000007321" } ] } } ], "crossref": [ { "id": "E1BDN8", "url": "https://alphafold.ebi.ac.uk/entry/E1BDN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12519", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12519", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507801", "url": "https://www.ncbi.nlm.nih.gov/gene/507801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507801", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MYPADEF", "url": "https://omabrowser.org/oma/group/MYPADEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDN8", "url": "https://www.orthodb.org/?gene=E1BDN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32343:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32343:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193066", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SP14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSAGSFGLGLGFGLTPTAVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEEAKALSLLAPAPTMTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSRSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKIKEKERVKEKDREKEREKERDREKEREKEKERGKNKDKDRDKEREKDRDKDKDKEKDKERERDKDHEKERDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKEKDHISERRERERSASTRKSSNDREGKDKVEKNNTSLKEKEHNKEPDSSVGKEVDDKDAPRTEENKVQQNGNCQPNEENLSAKTEAV", "length": 632, "header": "tr|E1BDN8-1|E1BDN8_BOVIN Isoform 1 of Splicing regulatory glutamine/lysine-rich protein 1 OS=Bos taurus OX=9913 GN=SREK1 PE=3 SV=3 CANONICAL=E1BDN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP14-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN8/entry#A0AAA9SP14-1", "sequence": { "sequence": "MNSAGSFGLGLGFGLTPTAVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEDD", "length": 100, "header": "tr|A0AAA9SP14-1|A0AAA9SP14_BOVIN Computationally mapped isoform of Splicing regulatory glutamic acid and lysine rich protein 1 OS=Bos taurus OX=9913 GN=SREK1 PE=4 SV=1 CANONICAL=E1BDN8-1" }, "locus": { "chromosome": "20", "start_pos": 13483891, "end_pos": 13470727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113134.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113134.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085639.1" } ] } }, { "isoform_ac": "E1BDN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN8/entry#E1BDN8-1", "sequence": { "sequence": "MNSAGSFGLGLGFGLTPTAVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEEAKALSLLAPAPTMTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSRSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKIKEKERVKEKDREKEREKERDREKEREKEKERGKNKDKDRDKEREKDRDKDKDKEKDKERERDKDHEKERDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKEKDHISERRERERSASTRKSSNDREGKDKVEKNNTSLKEKEHNKEPDSSVGKEVDDKDAPRTEENKVQQNGNCQPNEENLSAKTEAV", "length": 632, "header": "tr|E1BDN8-1|E1BDN8_BOVIN Isoform 1 of Splicing regulatory glutamine/lysine-rich protein 1 OS=Bos taurus OX=9913 GN=SREK1 PE=3 SV=3 CANONICAL=E1BDN8-1" }, "locus": { "chromosome": "20", "start_pos": 13483891, "end_pos": 13441066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009630.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009630.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009630.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009630.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507801", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507801", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B859-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "SREK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNSGGGFGLGLGFGLTPTAVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEEAKALSLLAPAPTMTGLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSRSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKIKEKERVKEKDREKEREKERDREKEREKEKERGKNKDKDRDKEREKDRDKDKEKDRDREREKEHEKERDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSTRKSSNDRDGKEKAEKNSTSLKEKEHNKEPDSNVGKEVDDKDPPPRTEENKVQQNGNCQPNEENLSTKTEAV", "length": 631 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y813-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "SREK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMNSGGIGVPLGFPLGPTSVIQVTNLSSAVTSEQMRTLFGFLGDIEELRLYPPDNAPLAFSSKVCYIKFREASSVGVAQHLTNTVFIDRALIVVPCAEGKIPDEAKALSLLAPAPTMTSLMPGAGLLPIPTPTPLTTLGVSLGTLGAIPAAALDPNITALGEIPQPPIMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSSERKGGRSRSHSRSESRSSSKSRSRRKRSHSKHRSRSGNRSLSRHKDRRRSRSPLKKRSRSRERRKSRSRSRSRDKKRDKEKVKEKEKTKEKERDRDKEKERDRDRDKEREREREKERNRDKDREKDKDRNKDRERVKDRDRDRDKEREKEKDEKEKDREDVDQNKEKDDDRDGERDREKMKDREGDKDKGGDKEKDREKEKEKDGDKEREREKERDDKKKKDKRSRTPPRSYSSSRRSRSSSRERRKRKSRSLSKSPKTSKGTKRKSSRTPSPRRNKKEKKRERDTCNEGRERERSTSKKKSSKEKEGREKSDKSTTTLKDKDHAKEDQNSETDKDVDNRDTQRTDEVKLQQNGNCQPNEDNLSIKMEEV", "length": 671 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2BIN4-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "srek1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGMPGTNVIQITNLSAAVSSDQMRTLFGFLGDIDELRLYPPDNAPLSFSSKVCYIKYREPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEEAKALSLLAPATPVASLMSGGGLLPIPSPSTLQNRSLPLANLGVLKSSLDTSVATLSAVSAQPPLMGNVDPSKVDEIRRTVYVGNLNSQSTTADQLLKFFKQVGDVKFVRMAGDETQPTRFAFVEFADQDSVARALTYNGVMFGDRPLKINHSNNAIVKPPELTPQAAAKELEDVMKKVREAQSTIAAAIEPENELPSSSRSRHSRRSRSHSCSPSNSRRKRSRSRHRGHPSKRSRQRFNDSCGSHRRHSRSRERRRSQSRSHSRGRRKDKDSKGRKDDDWDEKRLRDKTGRSPPKCYVGSRRSRSTSRGHKKRSRSPSRSPRQRARSPTPTKRGKREKKREKGWDSSRERAESSAFRRKSRDSEYKAKPSQRERVYEQMEHEYDSEMDGSGSMVSDDRSPPAHLNGSYRSSYAEEDNLFAAE", "length": 515 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H4M8-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "Srek1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNSGGGFGLGLGFGLFPTAVIQVTNLSSAVTSEQMRTLFSFLGDIEELRLYPPDNTPLAFSSKVCYIKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEEAKALSLLAPAPTMTSLVPGAGLLPIPTSSPLTAVSSLGVSLSSLGAIPAAALDPNITTLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKVKEKERVKEREREKEKEREREKDREKDKERGKNKDKDREKEKDHEKERDKDKEKDQDKDKEREKDKSKEADEKRKKDKKSRTPPRSYNASRRSRSTSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRGRNKKDKKREKERDHISDRRERERSTSTKKSSNDGKEKVEKTNTPVKKEHSKEADSSVSQDTDEKDPPRTEEENKVQQNGNCQPSEESLCSKADVV", "length": 611 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BZX4-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "Srek1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSLVPGAGLLPIPTSSPLTAVSSLGVSLSSLGAIPAAALDPNITTLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKVKERVKEKEREKEREREKDREKDKERGKNKDKDREKEKDHEKERDKEKEKEQDKDKEREKDRSKETDEKRKKEKKSRTPPRSYNASRRSRSTSRERRRRRSRSSSRSPRTSKTVKRKSSRSPSPRGRNKKEKKREKERDHISDRRERERSTSTKKSSGDRDGKEKVEKSTTPVKEKEHSKESDATVSKAADEKGSPRTEDEGKVQHNGNCQPNEESPCSKADAV", "length": 494 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXA9-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "SREK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEAV", "length": 508 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JKL7-1", "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "Srek1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSLVPGAGLLPIPTSSPLTAVSSLGVSLSSLGAIPAAALDPNITALGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRARSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKVKERVKEREREKEKEREKEREKDKERGKNKDKDREKEKDHEKERDKEKEKEQDKDKEREKDRSKEADEKRKKEKKSRTPPRSYNSSRRSRSASRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRGRNKKEKKREKERDHISDRRERERSTSTKKSSSDRDGKEKVEKTNTPVKEKEHSKEADSTVSTDADEKDTARTEEESKAQHNGNCQPHEERLCSTADAV", "length": 494 }, "evidence": [ { "id": "E1BDN8", "url": "https://omabrowser.org/oma/group/E1BDN8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1BDN8", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 579, "end_pos": 581, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDN8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 632, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDN8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDN8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN8" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 98, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 25, "end_pos": 27 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 578, "end_pos": 580 }, { "start_pos": 579, "end_pos": 581 }, { "start_pos": 624, "end_pos": 626 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDN9-1", "uniprot_ac": "E1BDN9", "uniprot_id": "E1BDN9_BOVIN", "mass": { "chemical_mass": 25010.0, "monoisotopic_mass": 25010.0 }, "refseq": { "ac": "XP_002697035", "name": "protein FAM3D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697035" }, "gene_names": [ { "name": "FAM3D", "type": "recommended", "evidence": [ { "id": "E1BDN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ] }, { "name": "FAM3D", "type": "synonym", "evidence": [ { "id": "XP_002697035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697035" } ] } ], "protein_names": [ { "name": "FAM3 metabolism regulating signaling molecule D", "type": "synonym", "evidence": [ { "id": "E1BDN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN9/entry#names_and_taxonomy" } ] }, { "name": "protein FAM3D", "type": "synonym", "evidence": [ { "id": "XP_002697035", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697035" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM3D", "url": "https://www.uniprot.org/uniprotkb/E1BDN9", "locus": { "chromosome": "22", "start_pos": 42717634, "end_pos": 42679343, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023207", "url": "https://www.ensembl.org/id/ENSBTAG00000023207" } ] } } ], "crossref": [ { "id": "E1BDN9", "url": "https://alphafold.ebi.ac.uk/entry/E1BDN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023207", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023207", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13940", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13940", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514459", "url": "https://www.ncbi.nlm.nih.gov/gene/514459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514459", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514459", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BDN9", "url": "https://www.orthodb.org/?gene=E1BDN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N1D8", "url": "https://www.orthodb.org/?gene=G3N1D8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697035", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697035", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUF8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUF8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1D8", "url": "https://www.uniprot.org/uniprotkb/G3N1D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1D8-1", "url": "https://www.uniprot.org/uniprotkb/G3N1D8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLSGLLRYLALIFAVATTWLFIREYINFNMKTFRLPRWMGSAHKNSSQLVKNKCGLSKSCPDNFFAFKIVSGAANVVGPTMCFEDQTIMSPVKNNVGRGLNVVLVDGTTGAVLTQKSFDMYSGDASLLTKFLKEISEDVLVLVASYDDPGTKMNDEIRKLFSNLGSTHVKQLGFRDSWVFLGAQNLKSKSPFEQFLKNNPETNKYDGWPELLELEGCVPRKV", "length": 223, "header": "tr|E1BDN9-1|E1BDN9_BOVIN Isoform 1 of FAM3 metabolism regulating signaling molecule D OS=Bos taurus OX=9913 GN=FAM3D PE=3 SV=4 CANONICAL=E1BDN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3Q8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN9/entry#A0AAA9T3Q8-1", "sequence": { "sequence": "PSQRPGFQAPSQALGAPLTGPSPHPLCRRRGSAPEEKTPTQLLTHHQAPSPVGLTTEACFFSTVTESCVCVCVCVCVCVRVCEEVAAASAEGLPDKIGLSAHFTPVPREGDCAWPGQHHSDFPSSPTPTQDPPPLCGQAQNTFSPDSVFSPTGSAHKNSSQLVKNKCGLSKSCPDNFFAFKIVSGAANVVGPTMCFEDQTIMSPVKNNVGRGLNVVLVDGTTGAVLTQKSFDMYSGDASLLTKFLKEISEDVLVLVASYDDPGTKMNDEIRKLFSNLGSTHVKQLGFRDSWVFLGAQNLKSKSPFEQFLKNNPETNKYDGWPELLELEGCVPRKV", "length": 335, "header": "tr|A0AAA9T3Q8-1|A0AAA9T3Q8_BOVIN Computationally mapped isoform of FAM3 metabolism regulating signaling molecule D OS=Bos taurus OX=9913 GN=FAM3D PE=3 SV=1 CANONICAL=E1BDN9-1" }, "locus": { "chromosome": "22", "start_pos": 42716630, "end_pos": 42699150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106760.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106760.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093434.1" } ] } }, { "isoform_ac": "A0ABI0NUF8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN9/entry#A0ABI0NUF8-1", "sequence": { "sequence": "MRLSGLLRYLALIFAVATTWLFIREYINFNMKTFRLPRWMGSAHKNSSQLVKNKCGLSKSCPDNFFAFKIVSGAANVVGPTMCFEDQTIMSPVKNNVGRGLNVVLVDGTTGAVLTQKSFDMYSGDASLLTKFLKEISEDVLVLVASYDDPGTKMNDEIRKLFSNLGSTHVKQLGFRDSWVFLGAQNLKSKSPFEQRSFQTQQNWASYSKGEARK", "length": 214, "header": "tr|A0ABI0NUF8-1|A0ABI0NUF8_BOVIN Computationally mapped isoform of FAM3 metabolism regulating signaling molecule D OS=Bos taurus OX=9913 GN=FAM3D PE=3 SV=1 CANONICAL=E1BDN9-1" }, "locus": { "chromosome": "22", "start_pos": 42714670, "end_pos": 42693907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104799.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104799.1" } ] } }, { "isoform_ac": "E1BDN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN9/entry#E1BDN9-1", "sequence": { "sequence": "MRLSGLLRYLALIFAVATTWLFIREYINFNMKTFRLPRWMGSAHKNSSQLVKNKCGLSKSCPDNFFAFKIVSGAANVVGPTMCFEDQTIMSPVKNNVGRGLNVVLVDGTTGAVLTQKSFDMYSGDASLLTKFLKEISEDVLVLVASYDDPGTKMNDEIRKLFSNLGSTHVKQLGFRDSWVFLGAQNLKSKSPFEQFLKNNPETNKYDGWPELLELEGCVPRKV", "length": 223, "header": "tr|E1BDN9-1|E1BDN9_BOVIN Isoform 1 of FAM3 metabolism regulating signaling molecule D OS=Bos taurus OX=9913 GN=FAM3D PE=3 SV=4 CANONICAL=E1BDN9-1" }, "locus": { "chromosome": "22", "start_pos": 42716630, "end_pos": 42693907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031567.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031567.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031518.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031518.6" } ] } }, { "isoform_ac": "G3N1D8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN9/entry#G3N1D8-1", "sequence": { "sequence": "MRLSGLLRYLALIFAVATTWLFIREYINFNMKTFRLPRWMASQLVKNKCGLSKSCPDNFFAFKIVSGAANVVGPTMCFEDQTIMSPVKNNVGRGLNVVLVDGTTGAVLTQKSFDMYSGDASLLTKFLKEISEDVLVLVASYDDPGTKMNDEIRKLFSNLGSTHVKQLGFRDSWVFLGAQNLKSKSPFEQFLKNNPETNKYDGWPELLELEGCVPRKV", "length": 217, "header": "tr|G3N1D8-1|G3N1D8_BOVIN Computationally mapped isoform of FAM3 metabolism regulating signaling molecule D OS=Bos taurus OX=9913 GN=FAM3D PE=3 SV=3 CANONICAL=E1BDN9-1" }, "locus": { "chromosome": "22", "start_pos": 42716630, "end_pos": 42693907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064429.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064429.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055678.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055678.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 81, "start_aa": "Thr", "end_pos": 81, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr81", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514459", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BDN9", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDN9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDN9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDN9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN9" }, { "id": "PF15711", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ILEI/PANDER", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 185, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 81 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDP4-1", "uniprot_ac": "E1BDP4", "uniprot_id": "E1BDP4_BOVIN", "mass": { "chemical_mass": 33571.0, "monoisotopic_mass": 33571.0 }, "refseq": { "ac": "NP_001178989", "name": "transmembrane protein 177", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178989" }, "gene_names": [ { "name": "TMEM177", "type": "recommended", "evidence": [ { "id": "E1BDP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDP4" } ] }, { "name": "TMEM177", "type": "synonym", "evidence": [ { "id": "NP_001178989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178989" } ] } ], "protein_names": [ { "name": "Transmembrane protein 177", "type": "recommended", "evidence": [ { "id": "E1BDP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDP4/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 177", "type": "synonym", "evidence": [ { "id": "NP_001178989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178989" } ] } ], "function": [ { "annotation": "Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.", "evidence": [ { "database": "UniProtKB", "id": "E1BDP4", "url": "https://www.uniprot.org/uniprotkb/E1BDP4#function" }, { "database": "UniProtKB", "id": "ARBA00003998", "url": "https://www.uniprot.org/uniprotkb/ARBA00003998#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDP4", "url": "https://www.uniprot.org/uniprotkb/E1BDP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM177", "url": "https://www.uniprot.org/uniprotkb/E1BDP4", "locus": { "chromosome": "2", "start_pos": 71483317, "end_pos": 71480984, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009058", "url": "https://www.ensembl.org/id/ENSBTAG00000009058" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009058", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009058", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505501", "url": "https://www.ncbi.nlm.nih.gov/gene/505501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026620", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026620", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505501", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HTFGLKY", "url": "https://omabrowser.org/oma/group/HTFGLKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDP4", "url": "https://www.orthodb.org/?gene=E1BDP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21824", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21824", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21824:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21824:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178989", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BDP4", "url": "https://www.uniprot.org/uniprotkb/E1BDP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPLWRATVFVQRHRTGLLVGSCAGLFGAQISYHLFPDPVVQWLYQYWPQGQPAPLSPELERLFQEVQQDIGIPSGHHFEAFTTFTFQPVSAGFPRLPGGAIVGIPASFLGGPVTNTDQPVVVHGQRVDWRSPAGTRLRDALTLSHDAQKFALAKEVVYLESGAAALQALPAPACLAGTWALGVGAKHALGLYGGPMSLRAAFNLVAAVAGFVAYAFSTDSLTHGLEAWLDRRTASLSAAYARGGVEFYEKVLSGNLALRSLLGQRGKKLYTPSGNVIPRHWFRIKHLPYTARRDSVLQMWRAALGPGSS", "length": 311, "header": "tr|E1BDP4-1|E1BDP4_BOVIN Isoform 1 of Transmembrane protein 177 OS=Bos taurus OX=9913 GN=TMEM177 PE=3 SV=2 CANONICAL=E1BDP4-1" }, "isoforms": [ { "isoform_ac": "E1BDP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP4/entry#E1BDP4-1", "sequence": { "sequence": "MAGPLWRATVFVQRHRTGLLVGSCAGLFGAQISYHLFPDPVVQWLYQYWPQGQPAPLSPELERLFQEVQQDIGIPSGHHFEAFTTFTFQPVSAGFPRLPGGAIVGIPASFLGGPVTNTDQPVVVHGQRVDWRSPAGTRLRDALTLSHDAQKFALAKEVVYLESGAAALQALPAPACLAGTWALGVGAKHALGLYGGPMSLRAAFNLVAAVAGFVAYAFSTDSLTHGLEAWLDRRTASLSAAYARGGVEFYEKVLSGNLALRSLLGQRGKKLYTPSGNVIPRHWFRIKHLPYTARRDSVLQMWRAALGPGSS", "length": 311, "header": "tr|E1BDP4-1|E1BDP4_BOVIN Isoform 1 of Transmembrane protein 177 OS=Bos taurus OX=9913 GN=TMEM177 PE=3 SV=2 CANONICAL=E1BDP4-1" }, "locus": { "chromosome": "2", "start_pos": 71481937, "end_pos": 71481005, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089560.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089560.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081973.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505501", "resource": "KEGG Pathway" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z1I4-1", "protein_name": "Transmembrane protein 177", "gene_name": "TMEM177", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGARFLRKASVWLKKHKITLLATSCVGLFGANLSYHVFPEQTFKLLHECWSDGRPAELSQSLCAVFQDVLQDTAVKSANYQAFAASGFHPVSAGIPWLPAGSLVGIPPNFDSTIEDKRGIVDHVVVIGGKEVDWESNEGVALKEALTFSLEAQKFALAREVVYLQNGSPLASAAVAPTCLAGTCLCGTVIKVVLGLYSGPRVLRSICNLIIAAAGLILYYISYDAMTYHLDCKADRNAATVSKDYAKGGVEFYDKILSRNRILRALMGKEGTKIYAPSGNIFPRHWFRIKYTPYTYRRDLIVNILKELQA", "length": 310 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1Z9W2-1", "protein_name": "Transmembrane protein 177", "gene_name": "CG10220", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLPKLKTGGGFFSYFKTEKGRKLVFYAAGATTVGLFLGNFLPHTFGLKYYRDFVQCYQHGVGRPVPEAVQQRLEKALDQLGVTPFERKFVKPFTVFGFDVFQAGTTKFRFGGALGIPVNYGYDSLEEIKRADIRFRDKQINWSSPSGKLLEEAIVLNEDEQIFGLSKAVLQMQTHRVLLNSIFPSVSFLMVYTMGHYLNLRLDLFARHGSVRFVLYSILGLFGLGLWSFMKDYNQVSTDAEIDQRLATMGPQLVAAGASFYDKHLKKNIALRELIGNDVYTALGNENYMIRQKSMPLTARKSFFLEKLEELKKAQQPETE", "length": 320 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1RXW5-1", "protein_name": "Transmembrane protein 177", "gene_name": "TMEM177", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPLWRATAFVQRHRTGLLVGSCAGLFGAQISYHLFPDPVVQWLYQYWPQGRPAPLSPELQGLFQEVLQDIGVPSGHHFEAFTTFTFQPVSAGFPRLHAGAVVGIPASFLGGPVTKADEPVVVHGQRVDWQNPAGARLRDALTLSRDAQKFALAREVVYLESSAAALQALPAPACLAGTWALSVVAKHALGLYGGPLNLRAAFNLLAAVAGFVAYAFCTDSLTHALEAWLDWRAASLSVAYAWGGVEFYEKVLSCNLALRSLLGRPGEQLYTPSGNVVPRHWFRIKHLPYTTRRDLVLQLWRAAHSSSSS", "length": 311 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4KM93-1", "protein_name": "Transmembrane protein 177", "gene_name": "Tmem177", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPLWRAAVFIQRHRTSLLVGSCVGLFGVQISFHLFPDPIVQWLYQYWPQGQPAPLSPQLRSLFQEVLKDIGVPSGHCYKPFTAFTFQPVSAGFPQLPAGAVVGIPAIFLGGLVTNIDHTVVIHGQKVDWQSPAGTRLRDALTLSHDAQKFALAKEVVYLESGMAALQTLPAPVCLAGTWAISVGAKHALGLYGGPMSLRAAFNLVAIVVGYVAYAFSKDSLTVALEGWLDHRTASLSAAYVRGGVEFYEKILSGNLALRSLLGRQGEKLYTPSGNIVPRHWFRINHLPYTTRRDSLLQMWRAKVSPGHF", "length": 311 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q53S58-1", "protein_name": "Transmembrane protein 177", "gene_name": "TMEM177", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPLWRTAAFVQRHRTGLLVGSCAGLFGVPISYHLFPDPVVQWLYQYWPQGQPAPLPPQLQSLFQEVLQDIGVPSGHCYKPFTTFTFQPVSAGFPRLPAGAVVGIPASFLGDLVINTNHPVVIHGHTVDWRSPAGARLRASLTLSREAQKFALAREVVYLESSTTAVHALLAPACLAGTWALGVGAKYTLGLHAGPMNLRAAFSLVAAVAGFVAYAFSQDSLTHAVESWLDRRTASLSAAYACGGVEFYEKLLSGNLALRSLLGKDGEKLYTPSGNIVPRHLFRIKHLPYTTRRDSVLQMWRGMLNPGRS", "length": 311 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PBI8-1", "protein_name": "Transmembrane protein 177", "gene_name": "tmem177", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSRFLKISVFIQKYRTPLLLIGCGGVFSANIFYHIFPDHTYKKVYQAWHKGEPASLSEKLQNIFQEVLKDSSISTSGNFSAFAAFGFHPVGAGVPWLPSGAQIGIPANFNSSTADLEGITNRTILINGKELEWDSDSGVALKNSLVFSLEAQKFAIAREVARLGSGGPILHAAVAPVCLAGACVYSVALKQIFRFQAGSIIFRGVVNLLSLGLGVMTYVLAADSVSQWLDYRSDRRAAGLSRDYAKGGLEFYEKILTRNKTLRSLMGQKGEEMYAPSGNLFPAHLLQLRHATYTSRRDRILNLLKNENV", "length": 310 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BPE4-1", "protein_name": "Transmembrane protein 177", "gene_name": "Tmem177", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGPLWRAAAFIQRHRTSLLVGSCAGLFGVQISFHLFPDPIVQWLYQYWPQGQPAPLSPHLWSLFQEVLKDIGVPSGHCYKPFTAFTFQPVSAGFPRLPAGAVVGIPAIFLGGPVTNIEHSVIIHGQRVDWQSPAGTRLRDALTMSHNAQKFALAKEVVYLESGVAALQTLPAPACLAGTWAISVGAKHALGLYGGPMSLRTAFNLVAIVVGYVAYTFSKDSLTLALEGWLDRRTASLSAAYVQGGVEFYEKILSGNLALRSLLGRQGEKLYTPSGNIVPRHWFRINHLPYTTRRDSLQQMWRATVSPGRF", "length": 311 }, "evidence": [ { "id": "E1BDP4", "url": "https://omabrowser.org/oma/group/E1BDP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1BDP4", "url": "https://www.uniprot.org/uniprotkb/E1BDP4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BDP4", "url": "https://www.uniprot.org/uniprotkb/E1BDP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDS1-1", "uniprot_ac": "E1BDS1", "uniprot_id": "E1BDS1_BOVIN", "mass": { "chemical_mass": 86839.0, "monoisotopic_mass": 86839.0 }, "refseq": { "ac": "NP_001039590", "name": "melanoma-associated antigen D1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039590" }, "gene_names": [ { "name": "MAGED1", "type": "recommended", "evidence": [ { "id": "E1BDS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS1" } ] }, { "name": "MAGED1", "type": "synonym", "evidence": [ { "id": "NP_001039590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039590" } ] } ], "protein_names": [ { "name": "MAGE family member D1", "type": "synonym", "evidence": [ { "id": "E1BDS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS1/entry#names_and_taxonomy" } ] }, { "name": "melanoma antigen family D, 1", "type": "synonym", "evidence": [ { "id": "NP_001039590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039590" } ] }, { "name": "melanoma-associated antigen D1", "type": "synonym", "evidence": [ { "id": "NP_001039590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039590" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDS1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAGED1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1", "locus": { "chromosome": "X", "start_pos": 89433441, "end_pos": 89426617, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008733", "url": "https://www.ensembl.org/id/ENSBTAG00000008733" } ] } } ], "crossref": [ { "id": "E1BDS1", "url": "https://alphafold.ebi.ac.uk/entry/E1BDS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008733", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008733", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512562", "url": "https://www.ncbi.nlm.nih.gov/gene/512562", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512562", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512562", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PNPMAWQ", "url": "https://omabrowser.org/oma/group/PNPMAWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDS1", "url": "https://www.orthodb.org/?gene=E1BDS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9768919", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768919", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRF0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRF0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P084", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P084", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P084-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P084-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDS1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTSQATAAASAPNASPQSSQPPAVSEMADTQALATATKPKTAFKVQNATTKGPNAAYDFSQAFNAKETPNILPTAHFKSQNAPAKGPNAAYDFSQAAPTGELTANKSDMAFKAQNTTTKVVPNAAYNFSQSLNASEMVNPQPKTAFKAWNDTTTAPTADPQTQNVNPAKMATSHTDIEADPSPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPVTTQSPPGAPPNVLWQTPLAWQNPSGWQNQPTRQTPPARQSPPTRQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPADWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 785, "header": "tr|E1BDS1-1|E1BDS1_BOVIN Isoform 1 of MAGE family member D1 OS=Bos taurus OX=9913 GN=MAGED1 PE=4 SV=2 CANONICAL=E1BDS1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRT8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1/entry#A0AAA9SRT8-1", "sequence": { "sequence": "MSEKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTSQATAAASAPNASPQSSQPPAVSEMADTQALATATKPKTAFKVQNATTKGPNAAYDFSQAFNAKETPNILPTAHFKSQNAPAKGPNAAYDFSQAAPTGELTANKSDMAFKAQNTTTKVVPNAAYNFSQSLNASEMVNPQPKTAFKAWNDTTTAPTADPQTQNVNPAKMATSHTDIEADPSPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPVTTQSPPGAPPNVLWQTPLAWQNPSGWQNQPTRQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPADWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 773, "header": "tr|A0AAA9SRT8-1|A0AAA9SRT8_BOVIN Computationally mapped isoform of MAGE family member D1 OS=Bos taurus OX=9913 GN=MAGED1 PE=4 SV=1 CANONICAL=E1BDS1-1" }, "locus": { "chromosome": "X", "start_pos": 89433011, "end_pos": 89427342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133211.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133211.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089099.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089099.1" } ] } }, { "isoform_ac": "A0ABI0NRF0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1/entry#A0ABI0NRF0-1", "sequence": { "sequence": "MALGFPGGSHGSALARETRIMSEKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTSQATAAASAPNASPQSSQPPAVSEMADTQALATATKPKTAFKVQNATTKGPNAAYDFSQAFNAKETPNILPTAHFKSQNAPAKGPNAAYDFSQAAPTGELTANKSDMAFKAQNTTTKVVPNAAYNFSQSLNASEMVNPQPKTAFKAWNDTTTAPTADPQTQNVNPAKMATSHTDIEADPSPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPVTTQSPPGAPPNVLWQTPLAWQNPSGWQNQPTRQTPPARQSPPTRQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPADWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 805, "header": "tr|A0ABI0NRF0-1|A0ABI0NRF0_BOVIN Computationally mapped isoform of MAGE family member D1 OS=Bos taurus OX=9913 GN=MAGED1 PE=4 SV=1 CANONICAL=E1BDS1-1" }, "locus": { "chromosome": "X", "start_pos": 89433011, "end_pos": 89412726, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153053.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153053.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106256.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106256.1" } ] } }, { "isoform_ac": "A0ABI0P084-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1/entry#A0ABI0P084-1", "sequence": { "sequence": "MSEKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTSQATAAASAPNASPQSSQPPAVSEMADTQALATATKPKTAFKVQNATTKGPNAAYDFSQAFNAKETPNILPTAHFKSQNAPAKGPNAAYDFSQAAPTGELTANKSDMAFKAQNTTTKVVPNAAYNFSQSLNASEMVNPQPKTAFKAWNDTTTAPTADPQTQNVNPAKMATSHTDIEADPSPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPVTTQSPPGAPPNVLWQTPLAWQNPSGWQNQPTRQTPPARQSPPTRQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPADWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEILLIRCNCLSPE", "length": 708, "header": "tr|A0ABI0P084-1|A0ABI0P084_BOVIN Computationally mapped isoform of MAGE family member D1 OS=Bos taurus OX=9913 GN=MAGED1 PE=4 SV=1 CANONICAL=E1BDS1-1" }, "locus": { "chromosome": "X", "start_pos": 89433269, "end_pos": 89427342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106249.1" } ] } }, { "isoform_ac": "E1BDS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1/entry#E1BDS1-1", "sequence": { "sequence": "MSEKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTSQATAAASAPNASPQSSQPPAVSEMADTQALATATKPKTAFKVQNATTKGPNAAYDFSQAFNAKETPNILPTAHFKSQNAPAKGPNAAYDFSQAAPTGELTANKSDMAFKAQNTTTKVVPNAAYNFSQSLNASEMVNPQPKTAFKAWNDTTTAPTADPQTQNVNPAKMATSHTDIEADPSPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPVTTQSPPGAPPNVLWQTPLAWQNPSGWQNQPTRQTPPARQSPPTRQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPADWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 785, "header": "tr|E1BDS1-1|E1BDS1_BOVIN Isoform 1 of MAGE family member D1 OS=Bos taurus OX=9913 GN=MAGED1 PE=4 SV=2 CANONICAL=E1BDS1-1" }, "locus": { "chromosome": "X", "start_pos": 89433011, "end_pos": 89427342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011507.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011507.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011507.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011507.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512562", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512562", "resource": "KEGG Pathway" }, { "id": "R-BTA-9768919", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768919", "resource": "Reactome", "description": "NPAS4 regulates expression of target genes" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HQ41-1", "protein_name": "Melanoma-associated antigen D1", "gene_name": "Maged1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQKPDGGAGLRGYQAEASVEDSALLVQTLMEAIQISEAPPTNQATAAASGQNVSPQSSQPPTANQVADTGVSTAAARPKTGFRAQNTFSKGPNDFSHARNAKEMSKNQSKAAYKSHNGTSKGPNAASNFSHGATTGKSAAKKSEIAFKVQNTTTKAGPGATYNFSQSPSANEMINNQPKTATKAWNDTTKVPAADAQIQNVNQAKMANVGTSPGISETGGAAAQTSADGSQAQNVESRTIIRGKRTRKINNLNVEENSSGDQRRASLASGNWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQAQPARQNPPARQTATAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQNAPGWQTPPSWQAPPSWQGPQDWQGPPDWQIPPDWSLPPDWSFSTDWPFPPDWIPADWPIPPDWQNLRPSPNLRSTPNARASQNQGAPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE", "length": 776 }, "evidence": [ { "id": "E1BDS1", "url": "https://omabrowser.org/oma/group/E1BDS1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6ITT4-1", "protein_name": "Melanoma-associated antigen D1", "gene_name": "MAGED1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQKMDCGAGLLGFQAEASVEDSTLLMQTLMEAIQISEAPPTNQATAAASGPNASPQSSQPPSANEVADIQALAAATKPKTAFKAQNATTKGPNAAYDFSQALNAKEIPSTPPTVAFKAPNAPSKGPNAAYDFSQAATTSELTAKPEMAFKAQNATTKVGPNATYNFSPSLNANEMVNTQPKTAFKAWNDTTKAPTAETQTQNINQAKMATSQADIEADPGPGICESDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEESSSGDQRRAPLAPGTWRSAPVPITTQSPPGAPPNVLWQTPLAWQNPSGWQNQPARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPTDWPVPPDWQNLRPSPNLRPSPNSRASQNLGASQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 784 }, "evidence": [ { "id": "E1BDS1", "url": "https://omabrowser.org/oma/group/E1BDS1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9ES73-1", "protein_name": "Melanoma-associated antigen D1", "gene_name": "Maged1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNTTTKGPNDYSQARNAKEMPKNQPKVAFKSQNATSKGPHAASDFSHAASTGKSAAKKSEMAFKGQNTTTKAGPSATYNFTQSPSANEMTNNQPKTAKAWNDTTKIPGADAQTQNVNQAKMADVGTSAGISETDGAAAQTSADGSQAQNVESRTIIRGKRTRKINNLNVEENSNGDQRRASLASGNWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQLPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSPNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE", "length": 775 }, "evidence": [ { "id": "E1BDS1", "url": "https://omabrowser.org/oma/group/E1BDS1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QYH6-1", "protein_name": "Melanoma-associated antigen D1", "gene_name": "Maged1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE", "length": 775 }, "evidence": [ { "id": "E1BDS1", "url": "https://omabrowser.org/oma/group/E1BDS1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y5V3-1", "protein_name": "Melanoma-associated antigen D1", "gene_name": "MAGED1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE", "length": 778 }, "evidence": [ { "id": "E1BDS1", "url": "https://omabrowser.org/oma/group/E1BDS1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1BDS1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDS1", "url": "https://www.uniprot.org/uniprotkb/E1BDS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 785, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDS1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS1" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 478, "end_pos": 676, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDS4-1", "uniprot_ac": "E1BDS4", "uniprot_id": "E1BDS4_BOVIN", "mass": { "chemical_mass": 30671.0, "monoisotopic_mass": 30671.0 }, "refseq": {}, "gene_names": [ { "name": "ABHD14A", "type": "recommended", "evidence": [ { "id": "E1BDS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" } ] } ], "protein_names": [ { "name": "Protein ABHD14A", "type": "recommended", "evidence": [ { "id": "E1BDS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS4/entry#names_and_taxonomy" } ] }, { "name": "Alpha/beta hydrolase domain-containing protein 14A", "type": "synonym", "evidence": [ { "id": "E1BDS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Possible role in granule neuron development.", "evidence": [ { "database": "UniProtKB", "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4#function" }, { "database": "UniProtKB", "id": "ARBA00056841", "url": "https://www.uniprot.org/uniprotkb/ARBA00056841#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABHD14A", "url": "https://www.uniprot.org/uniprotkb/E1BDS4", "locus": { "chromosome": "22", "start_pos": 48955358, "end_pos": 48961896, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053854", "url": "https://www.ensembl.org/id/ENSBTAG00000053854" } ] } } ], "crossref": [ { "id": "E1BDS4", "url": "https://alphafold.ebi.ac.uk/entry/E1BDS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053854", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053854", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDS4", "url": "https://www.orthodb.org/?gene=E1BDS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46197:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46197:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TG24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "NVAAPFDRWLHPSRARPTVAGPVIPVGPTVVQTSMSRSQVALLGLGLGLLFMLLLYVGLPGPPEQTSWLWGDSNVTILAGLTPGSSPIFYREVLPFHRAHRVDVVLLHGKAFSSRTWEQLGTLQLLAQRGYRAVALDLPGFGNSAPSKEASTEAGRAELLERVLQDLNVQNAVLVSPSLSGRYALPFLMRGHHQLRGFVPIAPASTQNYTQEQFQAVKTPTLILYGELDRTLARESLRQLRHLPNHATVKLRNAGHACYLHKPQDFHLELLAFLDHLL", "length": 278, "header": "tr|E1BDS4-1|E1BDS4_BOVIN Isoform 1 of Protein ABHD14A OS=Bos taurus OX=9913 GN=ABHD14A PE=3 SV=3 CANONICAL=E1BDS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TG24-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS4/entry#A0AAA9TG24-1", "sequence": { "sequence": "NVAAPFDRWLHPSRARPTVAGPVIPVGPTVVQTSMSRSQVALLGLGLGLLFMLLLYVGLPGPPEQTSWLWGDSNVTILAGLTPGSSPIFYREVLPFHRAHRLRLSSCMGSWTAPWLGSHCGSSATCPTTPR", "length": 131, "header": "tr|A0AAA9TG24-1|A0AAA9TG24_BOVIN Computationally mapped isoform of Abhydrolase domain containing 14A OS=Bos taurus OX=9913 GN=ABHD14A PE=4 SV=1 CANONICAL=E1BDS4-1" }, "locus": { "chromosome": "22", "start_pos": 48960449, "end_pos": 48955595, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109893.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109893.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097514.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097514.1" } ] } }, { "isoform_ac": "E1BDS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDS4/entry#E1BDS4-1", "sequence": { "sequence": "NVAAPFDRWLHPSRARPTVAGPVIPVGPTVVQTSMSRSQVALLGLGLGLLFMLLLYVGLPGPPEQTSWLWGDSNVTILAGLTPGSSPIFYREVLPFHRAHRVDVVLLHGKAFSSRTWEQLGTLQLLAQRGYRAVALDLPGFGNSAPSKEASTEAGRAELLERVLQDLNVQNAVLVSPSLSGRYALPFLMRGHHQLRGFVPIAPASTQNYTQEQFQAVKTPTLILYGELDRTLARESLRQLRHLPNHATVKLRNAGHACYLHKPQDFHLELLAFLDHLL", "length": 278, "header": "tr|E1BDS4-1|E1BDS4_BOVIN Isoform 1 of Protein ABHD14A OS=Bos taurus OX=9913 GN=ABHD14A PE=3 SV=3 CANONICAL=E1BDS4-1" }, "locus": { "chromosome": "22", "start_pos": 48960449, "end_pos": 48955506, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055077.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055077.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050280.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050280.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 29, "start_aa": "Thr", "end_pos": 29, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr29", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "E1BDS4", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDS4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDS4" }, { "id": "PF12697", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12697" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AB hydrolase-1", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 186, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 29 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDU2-1", "uniprot_ac": "E1BDU2", "uniprot_id": "E1BDU2_BOVIN", "mass": { "chemical_mass": 61466.0, "monoisotopic_mass": 61466.0 }, "refseq": { "ac": "NP_001414791", "name": "leucine-rich repeat-containing protein 71", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414791" }, "gene_names": [ { "name": "LRRC71", "type": "recommended", "evidence": [ { "id": "E1BDU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDU2" } ] }, { "name": "C3H1ORF92", "type": "synonym", "evidence": [ { "id": "NP_001414791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414791" } ] }, { "name": "LRRC71", "type": "synonym", "evidence": [ { "id": "NP_001414791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414791" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 71", "type": "synonym", "evidence": [ { "id": "E1BDU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDU2/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 71", "type": "synonym", "evidence": [ { "id": "NP_001414791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414791" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDU2", "url": "https://www.uniprot.org/uniprotkb/E1BDU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC71", "url": "https://www.uniprot.org/uniprotkb/E1BDU2", "locus": { "chromosome": "3", "start_pos": 13925539, "end_pos": 13938200, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012348", "url": "https://www.ensembl.org/id/ENSBTAG00000012348" } ] } } ], "crossref": [ { "id": "E1BDU2", "url": "https://alphafold.ebi.ac.uk/entry/E1BDU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511219", "url": "https://www.ncbi.nlm.nih.gov/gene/511219", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46984:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46984:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001414791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414791", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDU2", "url": "https://www.uniprot.org/uniprotkb/E1BDU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDU2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGEASAPPATSPRAPRPGIQKSSGAVTKKGDRGAKEKPATVLPPVGEEEPKNPEEYQCTGILEVDFAELCTRWGYTDFPKVVTRPRPQPTFAPSASTSEKPTVDDQRLSGSCSLNSLESKYVFFRPTIQVELEPEDKSVKEIYIRGWKVEERILGIFSKCLPSLSQLQAINLWKVGLTDKTLTTFIALLPLCSSTLRKVSLEGNPLPEQSYHKLMAADSTIAHLSLRNNNIDDHGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRPFELTHIEVVERRRLLLEKGSQERSRSPSTSRHGDSKTERDKNQLMGVSSFALVEKDKTQTVKTPKGLGKKKEKSGEVVKKEEKSGPGQSPTQGTPRKEDSAKAGKGKVTIPEQKLSKGKGAKTGSKEKRSILMESELVGEATEMVNPLLEPVEHRDGKVFMPGNKVLLHLNLLRNRITEVGLEAFLTVVQYQAQFAKSKSASKGPVGLLWLSLAKNCFSPQCPAYAMIQELMLPRDPISKCRHKEEEPVASST", "length": 559, "header": "tr|E1BDU2-1|E1BDU2_BOVIN Isoform 1 of Leucine rich repeat containing 71 OS=Bos taurus OX=9913 GN=LRRC71 PE=4 SV=4 CANONICAL=E1BDU2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFY2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDU2/entry#A0AAA9SFY2-1", "sequence": { "sequence": "MVPPRPRVRSAVALCPRTGPPRAVVVERDAEATPPQAGPAGAGESRDPRFSHLQGKPYRVWSCLLAPVRVPRVAADGRGMSGEASAPPATSPRAPRPGIQKSSGAVTKKGDRGAKEKPATVLPPVGEEEPKNPEEYQCTGILEVDFAELCTRWGYTDFPKVVTRPRPQPTFAPSASTSEKPTVDDQRLSGSCSLNSLESKYVFFRPTIQVELEPEDKSVKEIYIRGWKVEERILGIFSKCLPSLSQLQAINLWKVGLTDKTLTTFIALLPLCSSTLRKVSLEGNPLPEQSYHKLMAADSTIAHLSLRNNNIDDHGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRPFELTHIEVVERRRLLLEKGSQERSRSPSTSRHGDSKTERDKNQLMGVSSFALVEKDKTQTVKTPKGLGKKKEKSGEVVKKEEKSGPGQSPTQGTPRKEDSAKAGKGKVTIPEQKLSKGKGAKTGSKEKRSILMESEHSGQSLDYNRPSKHLVGEATEMVNPLLEPVEHRDGKVFMPGNKVLLHLNLLRNRITEVGLEAFLTVVQYQAQFAKSKSASKGPVGLLWLSLAKNCFSPQCPAYAMIQELMLPRDPISKCRHKEEEPVASST", "length": 652, "header": "tr|A0AAA9SFY2-1|A0AAA9SFY2_BOVIN Computationally mapped isoform of Leucine rich repeat containing 71 OS=Bos taurus OX=9913 GN=LRRC71 PE=4 SV=1 CANONICAL=E1BDU2-1" }, "locus": { "chromosome": "3", "start_pos": 13938001, "end_pos": 13925712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107227.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107227.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081378.1" } ] } }, { "isoform_ac": "E1BDU2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDU2/entry#E1BDU2-1", "sequence": { "sequence": "MSGEASAPPATSPRAPRPGIQKSSGAVTKKGDRGAKEKPATVLPPVGEEEPKNPEEYQCTGILEVDFAELCTRWGYTDFPKVVTRPRPQPTFAPSASTSEKPTVDDQRLSGSCSLNSLESKYVFFRPTIQVELEPEDKSVKEIYIRGWKVEERILGIFSKCLPSLSQLQAINLWKVGLTDKTLTTFIALLPLCSSTLRKVSLEGNPLPEQSYHKLMAADSTIAHLSLRNNNIDDHGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRPFELTHIEVVERRRLLLEKGSQERSRSPSTSRHGDSKTERDKNQLMGVSSFALVEKDKTQTVKTPKGLGKKKEKSGEVVKKEEKSGPGQSPTQGTPRKEDSAKAGKGKVTIPEQKLSKGKGAKTGSKEKRSILMESELVGEATEMVNPLLEPVEHRDGKVFMPGNKVLLHLNLLRNRITEVGLEAFLTVVQYQAQFAKSKSASKGPVGLLWLSLAKNCFSPQCPAYAMIQELMLPRDPISKCRHKEEEPVASST", "length": 559, "header": "tr|E1BDU2-1|E1BDU2_BOVIN Isoform 1 of Leucine rich repeat containing 71 OS=Bos taurus OX=9913 GN=LRRC71 PE=4 SV=4 CANONICAL=E1BDU2-1" }, "locus": { "chromosome": "3", "start_pos": 13937764, "end_pos": 13925712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016383.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016383.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016383.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016383.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDU2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 559, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDU2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDU2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 279, "end_pos": 281 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDV7-1", "uniprot_ac": "E1BDV7", "uniprot_id": "E1BDV7_BOVIN", "mass": { "chemical_mass": 113245.0, "monoisotopic_mass": 113245.0 }, "refseq": {}, "gene_names": [ { "name": "NAA25", "type": "recommended", "evidence": [ { "id": "E1BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ] } ], "protein_names": [ { "name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "type": "recommended", "evidence": [ { "id": "E1BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial distribution and morphology protein 20", "type": "synonym", "evidence": [ { "id": "E1BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#names_and_taxonomy" } ] }, { "name": "N-terminal acetyltransferase B complex subunit MDM20", "type": "synonym", "evidence": [ { "id": "E1BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#names_and_taxonomy" } ] }, { "name": "N-terminal acetyltransferase B complex subunit NAA25", "type": "synonym", "evidence": [ { "id": "E1BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression.", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7#function" }, { "database": "UniProtKB", "id": "ARBA00057542", "url": "https://www.uniprot.org/uniprotkb/ARBA00057542#function" }, { "database": "UniProtKB", "id": "A0AAA9SJ74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ74#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ05#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAA25", "url": "https://www.uniprot.org/uniprotkb/E1BDV7", "locus": { "chromosome": "17", "start_pos": 62129018, "end_pos": 62067779, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006666", "url": "https://www.ensembl.org/id/ENSBTAG00000006666" } ] } } ], "crossref": [ { "id": "E1BDV7", "url": "https://alphafold.ebi.ac.uk/entry/E1BDV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006666", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006666", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613372", "url": "https://www.ncbi.nlm.nih.gov/gene/613372", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDV7", "url": "https://www.orthodb.org/?gene=E1BDV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22767", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22767", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22767:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22767:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFILAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVRFIEDRITEESKNSRHLRGPHLAKLELIRRLRRQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQRHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDVWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLNHSVGPKNSEKTTENGVSSRIDILRLLLQQLEVALETGKRFIEKDIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDINGLVFHCLSIVEDTVEIQERVENSLKSLLEQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFLVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI", "length": 980, "header": "tr|E1BDV7-1|E1BDV7_BOVIN Isoform 1 of N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Bos taurus OX=9913 GN=NAA25 PE=3 SV=4 CANONICAL=E1BDV7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ74-1", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#A0AAA9SJ74-1", "sequence": { "sequence": "MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFILAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVRFIEDRITEESKNSRHLRGPHLAKLELIRRLRRQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQRHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDVWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLNHSVGPKNSEKTTENGVSSRIDILRLLLQQLEVALETGKRFIEKDIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDINGLDVFSKCKGDLLEVKDGNLKTHPTLLENLVFLVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI", "length": 950, "header": "tr|A0AAA9SJ74-1|A0AAA9SJ74_BOVIN Computationally mapped isoform of N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Bos taurus OX=9913 GN=NAA25 PE=3 SV=1 CANONICAL=E1BDV7-1" }, "locus": { "chromosome": "17", "start_pos": 62128822, "end_pos": 62067802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118385.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118385.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085386.1" } ] } }, { "isoform_ac": "A0AAA9TJ01-1", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#A0AAA9TJ01-1", "sequence": { "sequence": "MATRGHVQDPNDRRLRPIYAELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVRFIEDRITEESKNSRHLRGPHLAKLELIRRLRRQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQRHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDVWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLNHSVGPKNSEKTTENGVSSRIDILRLLLQQLEVALETGKRFIEKDIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDINGLEDTVEIQERVENSLKSLLEQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFLVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI", "length": 897, "header": "tr|A0AAA9TJ01-1|A0AAA9TJ01_BOVIN Computationally mapped isoform of N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Bos taurus OX=9913 GN=NAA25 PE=3 SV=1 CANONICAL=E1BDV7-1" }, "locus": { "chromosome": "17", "start_pos": 62128822, "end_pos": 62067802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107972.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107972.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098424.1" } ] } }, { "isoform_ac": "A0AAA9TJ05-1", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#A0AAA9TJ05-1", "sequence": { "sequence": "MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFILAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVRFIEDRITEESKNSRHLRGPHLAKLELIRRLRRQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQRHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDVWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLNHSVGPKNSEKTTENGVSSRIDILRLLLQQLEVALETGKRFIEKDIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDINGLEDTVEIQERVENSLKSLLEQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFLVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI", "length": 947, "header": "tr|A0AAA9TJ05-1|A0AAA9TJ05_BOVIN Computationally mapped isoform of N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Bos taurus OX=9913 GN=NAA25 PE=3 SV=1 CANONICAL=E1BDV7-1" }, "locus": { "chromosome": "17", "start_pos": 62128822, "end_pos": 62067802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089930.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089930.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096224.1" } ] } }, { "isoform_ac": "E1BDV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDV7/entry#E1BDV7-1", "sequence": { "sequence": "MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFILAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVRFIEDRITEESKNSRHLRGPHLAKLELIRRLRRQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQRHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDVWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLNHSVGPKNSEKTTENGVSSRIDILRLLLQQLEVALETGKRFIEKDIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDINGLVFHCLSIVEDTVEIQERVENSLKSLLEQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFLVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI", "length": 980, "header": "tr|E1BDV7-1|E1BDV7_BOVIN Isoform 1 of N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Bos taurus OX=9913 GN=NAA25 PE=3 SV=4 CANONICAL=E1BDV7-1" }, "locus": { "chromosome": "17", "start_pos": 62128822, "end_pos": 62067802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008756.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008756.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008756.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008756.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "pmid": "" }, { "name": "NatB complex", "id": "GO:0031416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031416", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acetyltransferase activator activity", "id": "GO:0010698", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010698", "evidence": [ { "database": "UniProtKB", "id": "E1BDV7", "url": "https://www.uniprot.org/uniprotkb/E1BDV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDV7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 980, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDV7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDV7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 704, "end_pos": 706 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDX0-1", "uniprot_ac": "E1BDX0", "uniprot_id": "E1BDX0_BOVIN", "mass": { "chemical_mass": 90038.0, "monoisotopic_mass": 90038.0 }, "refseq": { "ac": "XP_003586682", "name": "intron Large complex component GCFC2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586682" }, "gene_names": [ { "name": "GCFC2", "type": "recommended", "evidence": [ { "id": "E1BDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" } ] }, { "name": "GCFC2", "type": "synonym", "evidence": [ { "id": "XP_003586682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586682" } ] } ], "protein_names": [ { "name": "GC-rich sequence DNA-binding factor 2", "type": "synonym", "evidence": [ { "id": "E1BDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDX0/entry#names_and_taxonomy" } ] }, { "name": "intron Large complex component GCFC2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_003586682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586682" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDX0", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCFC2", "url": "https://www.uniprot.org/uniprotkb/E1BDX0", "locus": { "chromosome": "11", "start_pos": 43999530, "end_pos": 43921059, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008048", "url": "https://www.ensembl.org/id/ENSBTAG00000008048" } ] } } ], "crossref": [ { "id": "E1BDX0", "url": "https://alphafold.ebi.ac.uk/entry/E1BDX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008048", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008048", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521363", "url": "https://www.ncbi.nlm.nih.gov/gene/521363", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521363", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521363", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQAMTLM", "url": "https://omabrowser.org/oma/group/KQAMTLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDX0", "url": "https://www.orthodb.org/?gene=E1BDX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12214:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12214:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07842", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07842", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003586682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDX0", "url": "https://www.uniprot.org/uniprotkb/E1BDX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDX0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHRPKRTFRPRRADSSDSDGAQETFAEPGATGEQAARDPAVEGPPSGRGHAEVAELLRRGRGRRRGRAWASSRHAARAAPRLDESSDVPESRMVDLSADEEDGEHHSSESKDDQSSSPNSSRTLEDEFSSVVNIPDAAVMQATYRKCKLARAQEDYISLDVKHTFTNSGMKKNSEDSESEPDDFKDIMPFTPKPQTLRQRMAEETTTRNEETSDDSQDEKTQDIWEQQQMRKAVKITKGQDIDLSYSHESQTVKKFDASISFPPVSLEIIKKKLNTRLTLLQDTHRSHLREYEKYIQDIKSSKSTIQNLENSSNQTLSFRFYKSMKIYVENLIDCLNEKIISIQEIESAMHALLLKQAMIFMKRRQDELKHESAYLQQLSCKPETSINKSLAMDEKTQWILEEAESRRARRRQARVLSGNCTHEEGTSSDDELSSADMIDFQKSQGDILQDHKKIFEDVHSDFCNIQNILLKFRQWREKFPDSYYEAFISLCIPKLLNPLIRFQLIDWNPLKFDSIGLKQMPWFTSIEEFIDCSMEDSKKEDSSDKKILSTVINKTVIPRLIGFVEFIWDPLSTTQTTSLVTQCRMILEEHSTCENEVNKGKQDLLKSIVSRMKKAIEDDVFIPLYPKSAVENRTSPHSKFQERQFWSGLKLFGNILLWNELLPEDTLQELGLGKLLNRYLIIALLNAIPGSDVVKKCSQIAAYLPEKWFQNSAMRTSIPQLENFIQFLLQSARKLSRNEIRDELKEIILILVKIKALNQAESFIEECHLDHLRSVIKEFE", "length": 782, "header": "tr|E1BDX0-1|E1BDX0_BOVIN Isoform 1 of GC-rich sequence DNA-binding factor 2 OS=Bos taurus OX=9913 GN=GCFC2 PE=3 SV=3 CANONICAL=E1BDX0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQC9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX0/entry#A0A3Q1LQC9-1", "sequence": { "sequence": "MAHRPKRTFRPRRADSSDSDGAQETFAEPGATGEQAARDPAVEGPPSGRGHAEVAELLRRGRGRRRGRAWASSRHAARAAPRLDESSDVPESRMVDLSADEEDGEHHSSESKDDQSSSPNSSRTLEDEFSSVVNIPDAAVMQATYRKCKLARAQEDYISLDVKHTFTNSGMKKNSEDSESEPDDFKDIMPFTPKPQTLRQRMAEETTTRNEETSDDSQDEKTQDIWEQQQMRKAVKITKGIFPTQGSNQGLPHCRRILYQLSHKGSPTCGYPHCFQGQDIDLSYSHESQTVKKFDASISFPPVSLEIIKKKLNTRLTLLQDTHRSHLREYEKYIQDIKSSKSTIQNLENSSNQTLSFRFYKSMKIYVENLIDCLNEKIISIQEIESAMHALLLKQAMIFMKRRQDELKHESAYLQQLSCKPETSINKSLAMDEKTQWILEEAESRRARRRQARVLSGNCTHEEGTSSDDELSSADMIDFQKSQGDILQDHKKIFEDVHSDFCNIQNILLKFRQWREKFPDSYYEAFISLCIPKLLNPLIRFQLIDWNPLKFDSIGLKQMPWFTSIEEFIDCSMEDSKKEDSSDKKILSTVINKTVIPRLIGFVEFIWDPLSTTQTTSLVTQCRMILEEHSTCENEVNKGKQDLLKSIVSRMKKAIEDDVFIPLYPKSAVENRTSPHSKFQERQFWSGLKLFGNILLWNELLPEDTLQELGLGKLLNRYLIIALLNAIPGSDVVKKCSQIAAYLPEKWFQNSAMRTSIPQLENFIQFLLQSARKLSRNEIRDELKEIILILVKIKALNQAESFIEECHLDHLRSVIKEFE", "length": 819, "header": "tr|A0A3Q1LQC9-1|A0A3Q1LQC9_BOVIN Computationally mapped isoform of GC-rich sequence DNA-binding factor 2 OS=Bos taurus OX=9913 GN=GCFC2 PE=3 SV=2 CANONICAL=E1BDX0-1" }, "locus": { "chromosome": "11", "start_pos": 43998526, "end_pos": 43921258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075814.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075814.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059274.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059274.2" } ] } }, { "isoform_ac": "E1BDX0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX0/entry#E1BDX0-1", "sequence": { "sequence": "MAHRPKRTFRPRRADSSDSDGAQETFAEPGATGEQAARDPAVEGPPSGRGHAEVAELLRRGRGRRRGRAWASSRHAARAAPRLDESSDVPESRMVDLSADEEDGEHHSSESKDDQSSSPNSSRTLEDEFSSVVNIPDAAVMQATYRKCKLARAQEDYISLDVKHTFTNSGMKKNSEDSESEPDDFKDIMPFTPKPQTLRQRMAEETTTRNEETSDDSQDEKTQDIWEQQQMRKAVKITKGQDIDLSYSHESQTVKKFDASISFPPVSLEIIKKKLNTRLTLLQDTHRSHLREYEKYIQDIKSSKSTIQNLENSSNQTLSFRFYKSMKIYVENLIDCLNEKIISIQEIESAMHALLLKQAMIFMKRRQDELKHESAYLQQLSCKPETSINKSLAMDEKTQWILEEAESRRARRRQARVLSGNCTHEEGTSSDDELSSADMIDFQKSQGDILQDHKKIFEDVHSDFCNIQNILLKFRQWREKFPDSYYEAFISLCIPKLLNPLIRFQLIDWNPLKFDSIGLKQMPWFTSIEEFIDCSMEDSKKEDSSDKKILSTVINKTVIPRLIGFVEFIWDPLSTTQTTSLVTQCRMILEEHSTCENEVNKGKQDLLKSIVSRMKKAIEDDVFIPLYPKSAVENRTSPHSKFQERQFWSGLKLFGNILLWNELLPEDTLQELGLGKLLNRYLIIALLNAIPGSDVVKKCSQIAAYLPEKWFQNSAMRTSIPQLENFIQFLLQSARKLSRNEIRDELKEIILILVKIKALNQAESFIEECHLDHLRSVIKEFE", "length": 782, "header": "tr|E1BDX0-1|E1BDX0_BOVIN Isoform 1 of GC-rich sequence DNA-binding factor 2 OS=Bos taurus OX=9913 GN=GCFC2 PE=3 SV=3 CANONICAL=E1BDX0-1" }, "locus": { "chromosome": "11", "start_pos": 43998526, "end_pos": 43921258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010591.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010591.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010591.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010591.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521363", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521363", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AVA2-1", "protein_name": "GC-rich sequence DNA-binding factor 2", "gene_name": "Gcfc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRPQRTFRRRQVDSSDSDSDGTKEQSAEEPAESGRPSAGGRTEGAERPRGARSARGRGRVWASSRRSPGAASRGDGGAECRTADLSTDEEEGELPLPENKDDESPSSDSSCSLEEKEVSPIVKIPDAAFIQAARRKRELARTPGDYISLDVNHPSTTSESKRSNGEDSESDPDDHEKRILFTPKPQTLRQRMAEESSIRNEDSSEESQEDESQDTWEQQQMRKAVRITEGQSIDLLHSSKSQTLKKFDSSISFAPVNLEIIKKQLNSRLTLLQDSHRSHQREYEKYEQDIKSSKTAIEKLESGPDQALNYKFYKGMKIYVENIIDCLNEKISSIVELESSMYTLLLKHSEALLKRRQDELKCESSYLQQLSRKDETLASGSLALDEKDQRILEEIEARRVQRRQARVLSGNCDHQEGTSSDEELSPAEMTNFHKRQGDILQDCKKVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSMGLDRMPWFTAITEFMESGMEDVGKEDGSDKKILSAVINKTVVPRLTDFVEMIWDPLSTSQTRILTVHCRVAFEQFASETEVSKSKQDLLKSVAARMKKSIEDDVFIPLYPKSSEEGKMSPHSKFQERQFWGALKLFGNILLWNGLLPDDILQNLGLGKLLNRYLIIALTNAIPGPDVVKKCSQIAACLPDKWFENSAMRTSLPQLENFVQFLLQSARKLSTTEFRNELNGIILILVKVKALSQAESLTEEHRLEPLTAQTAGV", "length": 772 }, "evidence": [ { "id": "E1BDX0", "url": "https://omabrowser.org/oma/group/E1BDX0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7GFZ5-1", "protein_name": "GC-rich sequence DNA-binding factor 2 isoform X1", "gene_name": "Gcfc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALRPQRTFRRRQVESSDSDGDGAEERPAEVPADAGRPSAGGRAEGAEPPRRARGNRGRGRVWASSRRSPGTASRRDRGAVIFLESGTVDLSTDEEEEAHPSSESKDDQSPASHSSSSLEEKEVSPIVKIPDAAFIQEARRKRELARTPGDYISLDVNHPSTTCDNKRSNEEDPESDPDDYEKRILFAPKPQTLRQRMAEETSFRNEEESEDSQEDENQDIWEQQQMRKAVKIREGQNIDLSPKSDSQTLKKFDTSISFPPVNLEIIKKQLNNRLTLLQDTHRSHQREYEKYIEDIKSSKTAIQNLENASDQTLNYKFYKGMKIYVENIIDCLNEKIVIIEELESSTYTLLFKQSEALLKRRQDELKCESSYLQQLSRKAETSVNGSLAPDEKDQRILEEIEARRMQRRQARALSGNCDHQEGTSSDDELAPAEMTNFQKRQGDILQDCKRVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKLDSMALNQMPWFTSITEFMDGSSEDPREEDGSDKKMLSAVINKTVVPRLADFVEFIWDPMSTSQTRSLTVHCRLLFEQLASENEVSKSKQDLLKSVVGRIKKSIEDDVFIPLYPKSSEEGKMSPHSKFQERQFWGALKLFRNILLWNGLLSDDTLQDLGLGKLLNRYLIIALTNAIPGPDAVKKCSQIAACLPEKWFENSAMRTSIPQLENFIQFLLQSAHKLSTGEFRNEVNEIILILVKVKALNQAESLREEHHLEPPISPISGV", "length": 776 }, "evidence": [ { "id": "E1BDX0", "url": "https://omabrowser.org/oma/group/E1BDX0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LDF5-1", "protein_name": "GC-rich sequence DNA-binding factor 2", "gene_name": "GCFC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHRPQRTFRQRRTDSSDSDSGQEPTAEPGVPGEQVAPGPAEEGMLSEGGCAEVAERLRRARGGGRGRGRVWASSRRAAKAAPRLDPGSDAPESRTVDLSTDREDGIHHSSESKDDQSSSSNSSSSLEEEEEFLSTVNVPDAAFIQAAYRKRELARAQEDYISLDVKHVSNISNMKKNSEGSESEPDDHENIIPFTPKPQTLRQRMAEETTNRDEETSEDSQEDENQDIWEQQQMRKAVKITEGRDIDLSYSSESQTVKKFDVSISFPPINLEIIKKQLNNRLTLLQDTHRSHLREYEKYVEDIKTSKSTIQNLENSSSQALNFKFYKSMKIYVENLIDCLNEKIISIQEIESAMHALLLKQAMIFMKRRQDELKHEATYLQQLSRKAEASTNRGLDVDEKTQWIFEEIESRRAQRRQARALSGNCTHQEGMSSDDELSSADTIDFQKSRGDILQNHKKIFEDVHDDFCNIQNILLKFQQWREKFPDSYYEAFISLCIPKLLNPLIRFQLIDWNPLKFDSIGLKQMPWFTSIKEFIDSSMEDSKKKNSSDKKILSAVINKAVIPRLSDFVEFVWDPLSTSQTTSLIRQCKMILEEHSTCENEDSKGKQDLLKRIVLRMKKAIEDDVFIPLYPLSATENRTSPHAKFQERQFWSGLKLFHNILLWNGLIPEDTLQELGLGKLLNRYLIVALNAIPGPDVVKKCNQIAAYLPEEWFQNSAMRTSIPQLENFIQFLLQSAHKLSRSEIRDEIKEIIIILVKIKALTQAESFLEEYHLDHLKSVIKEV", "length": 784 }, "evidence": [ { "id": "E1BDX0", "url": "https://omabrowser.org/oma/group/E1BDX0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16383-1", "protein_name": "Intron Large complex component GCFC2", "gene_name": "GCFC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAHRPKRTFRQRAADSSDSDGAEESPAEPGAPRELPVPGSAEEEPPSGGGRAQVAGLPHRVRGPRGRGRVWASSRRATKAAPRADEGSESRTLDVSTDEEDKIHHSSESKDDQGLSSDSSSSLGEKELSSTVKIPDAAFIQAARRKRELARAQDDYISLDVQHTSSISGMKRESEDDPESEPDDHEKRIPFTLRPQTLRQRMAEESISRNEETSEESQEDEKQDTWEQQQMRKAVKIIEERDIDLSCGNGSSKVKKFDTSISFPPVNLEIIKKQLNTRLTLLQETHRSHLREYEKYVQDVKSSKSTIQNLESSSNQALNCKFYKSMKIYVENLIDCLNEKIINIQEIESSMHALLLKQAMTFMKRRQDELKHESTYLQQLSRKDETSTSGNFSVDEKTQWILEEIESRRTKRRQARVLSGNCNHQEGTSSDDELPSAEMIDFQKSQGDILQKQKKVFEEVQDDFCNIQNILLKFQQWREKFPDSYYEAFISLCIPKLLNPLIRVQLIDWNPLKLESTGLKEMPWFKSVEEFMDSSVEDSKKESSSDKKVLSAIINKTIIPRLTDFVEFLWDPLSTSQTTSLITHCRVILEEHSTCENEVSKSRQDLLKSIVSRMKKAVEDDVFIPLYPKSAVENKTSPHSKFQERQFWSGLKLFRNILLWNGLLTDDTLQELGLGKLLNRYLIIALLNATPGPDVVKKCNQVAACLPEKWFENSAMRTSIPQLENFIQFLLQSAHKLSRSEFRDEVEEIILILVKIKALNQAESFIGEHHLDHLKSLIKED", "length": 781 }, "evidence": [ { "id": "E1BDX0", "url": "https://omabrowser.org/oma/group/E1BDX0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BKT3-1", "protein_name": "Intron Large complex component GCFC2", "gene_name": "Gcfc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRPQRTFRRRQVESSDSDSDSDGAKEQSAEEPASAGGRTEGAERPRGARSARGRGRVWASSRRSPGAAPRGDGGAECRTAELSTDEEEGTHTLTGSKGDRSPSSDSSCSLEERDVSPIVEIPDAAFIQAARRKRELARTPGDYISLDVNHSCSTSDCKRSNEEDPESDPDDHEKRILFTPKPQTLRQRMAEETSIRSEESSEESQEDENQDIWEQQQMRKAVRIPAGQNTDLSHSSKSQTLKKFDTSISFPPVNLEIIKKQLNNRLTLLQESHRSHQREYEKYEQDIKSSKTAIQNLESASDHAQNYRFYRGMKSYVENIIDCLNEKIVSIVELESSMYTLLLKRSEALLKRRQDELKCESSYLQQLSRKDETSANGSLAVDEKDQRILEEIEARRMQRRQARELSGSCDHQEGMSSDDELSPAEMTNFHKCQGDILQDCKKVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSIGLDKMPWFTAITEFMESSMDDIGKEDGSDKKILAAVINKTVVPRLTDFVETIWDPLSTSQTRSLTVHCRVAFEQFASENEVSKNKQDLLKSIVARMKKSIEDDIFIPLYPKSSEEGKMSPHSKFQERQFWGALKLFRNILLWNGLLPDDTLQDLGLGKLLNRYLIISLTNAVPGPDVVKKCSQIAACLPERWFENSAMRTSIPQLENFIKFLLQSAQKLSSSEFRNEVSEIILILVKVKALTQAESLREERPLEPLPAQSTGV", "length": 769 }, "evidence": [ { "id": "E1BDX0", "url": "https://omabrowser.org/oma/group/E1BDX0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BDX0", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDX0", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "E1BDX0", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDX0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 782, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDX0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDX0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDX0" }, { "id": "PF07842", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GCF C-terminal", "eco_id": "ECO_0000259", "start_pos": 468, "end_pos": 682, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 555, "end_pos": 557 }, { "start_pos": 634, "end_pos": 636 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDX3-1", "uniprot_ac": "E1BDX3", "uniprot_id": "E1BDX3_BOVIN", "mass": { "chemical_mass": 44002.0, "monoisotopic_mass": 44002.0 }, "refseq": { "ac": "XP_015327831", "name": "magnesium transporter NIPA4 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327831" }, "gene_names": [ { "name": "NIPAL4", "type": "recommended", "evidence": [ { "id": "E1BDX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDX3" } ] }, { "name": "NIPAL4", "type": "synonym", "evidence": [ { "id": "XP_015327831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327831" } ] } ], "protein_names": [ { "name": "NIPA like domain containing 4", "type": "synonym", "evidence": [ { "id": "E1BDX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDX3/entry#names_and_taxonomy" } ] }, { "name": "magnesium transporter NIPA4 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015327831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327831" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDX3", "url": "https://www.uniprot.org/uniprotkb/E1BDX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIPAL4", "url": "https://www.uniprot.org/uniprotkb/E1BDX3", "locus": { "chromosome": "7", "start_pos": 69116299, "end_pos": 69101752, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020213", "url": "https://www.ensembl.org/id/ENSBTAG00000020213" } ] } } ], "crossref": [ { "id": "E1BDX3", "url": "https://alphafold.ebi.ac.uk/entry/E1BDX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020213", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020213", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532275", "url": "https://www.ncbi.nlm.nih.gov/gene/532275", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532275", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532275", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MGAGEVC", "url": "https://omabrowser.org/oma/group/MGAGEVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDX3", "url": "https://www.orthodb.org/?gene=E1BDX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5223345", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015327831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327831", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T7C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZM8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZM8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDX3", "url": "https://www.uniprot.org/uniprotkb/E1BDX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELPASNSSCENGSLISLYCSSQKVLCQIISDLQPEVPSNVTSNSWQERFRKNYSFYVGLGLAILSSFLVGSSIILKKKGLQRLVASGATRAVDGGYGYLKDSMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSILISAIFSSYFLGESLNLLGKLGCVICVAGSTVMVIHAPEEEKISTIMEMAAKMKDTGYIVFAVFLLVSCLILIFVVAPRYGQRNILIYITICSVIGAFSVSSSKGLGITIRNFFQGLPVVRHPLPYILSLMLALSISTQVNFLNRALDIFNTSLVFPIYYVFFTTTVMTSSIILFKEWYRMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISRSSLPHMHKNPPATPAPEPSVIRLGDKNVLVDNMELSSTPSPEEKPKVFIAHS", "length": 404, "header": "tr|E1BDX3-1|E1BDX3_BOVIN Isoform 1 of NIPA like domain containing 4 OS=Bos taurus OX=9913 GN=NIPAL4 PE=3 SV=2 CANONICAL=E1BDX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7C8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX3/entry#A0AAA9T7C8-1", "sequence": { "sequence": "MELPASNSSCENGSLISLYCSSQKVLCQIISDLQPEVPSNVTSNSWQERFRKNYSFYVGLGLAILSSFLVGSSIILKKKGLQRLVASGATRAVAAGEVANFGAYAFAPATVVTPLGALSILISAIFSSYFLGESLNLLGKLGCVICVAGSTVMVIHAPEEEKISTIMEMAAKMKDTGYIVFAVFLLVSCLILIFVVAPRYGQRNILIYITICSVIGAFSVSSSKGLGITIRNFFQGLPVVRHPLPYILSLMLALSISTQVNFLNRALDIFNTSLVFPIYYVFFTTTVMTSSIILFKEWYRMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISRSSLPHMHKNPPATPAPEPSVIRLGDKNVLVDNMELSSTPSPEEKPKVFIAHS", "length": 385, "header": "tr|A0AAA9T7C8-1|A0AAA9T7C8_BOVIN Computationally mapped isoform of NIPA like domain containing 4 OS=Bos taurus OX=9913 GN=NIPAL4 PE=3 SV=1 CANONICAL=E1BDX3-1" }, "locus": { "chromosome": "7", "start_pos": 69115295, "end_pos": 69101797, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135840.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135840.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092656.1" } ] } }, { "isoform_ac": "A0ABI0NZM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX3/entry#A0ABI0NZM8-1", "sequence": { "sequence": "MSYLGTKTLLSCGQRLPMGLHTQRGSLISLYCSSQKVLCQIISDLQPEVPSNVTSNSWQERFRKNYSFYVGLGLAILSSFLVGSSIILKKKGLQRLVASGATRAVDGGYGYLKDSMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSILISAIFSSYFLGESLNLLGKLGCVICVAGSTVMVIHAPEEEKISTIMEMAAKMKDTGYIVFAVFLLVSCLILIFVVAPRYGQRNILIYITICSVIGAFSVSSSKGLGITIRNFFQGLPVVRHPLPYILSLMLALSISTQVNFLNRALDIFNTSLVFPIYYVFFTTTVMTSSIILFKEWYRMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISRSSLPHMHKNPPATPAPEPSVIRLGDKNVLVDNMELSSTPSPEEKPKVFIAHS", "length": 416, "header": "tr|A0ABI0NZM8-1|A0ABI0NZM8_BOVIN Computationally mapped isoform of NIPA like domain containing 4 OS=Bos taurus OX=9913 GN=NIPAL4 PE=3 SV=1 CANONICAL=E1BDX3-1" }, "locus": { "chromosome": "7", "start_pos": 69115295, "end_pos": 69103662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145605.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145605.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104286.1" } ] } }, { "isoform_ac": "E1BDX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDX3/entry#E1BDX3-1", "sequence": { "sequence": "MELPASNSSCENGSLISLYCSSQKVLCQIISDLQPEVPSNVTSNSWQERFRKNYSFYVGLGLAILSSFLVGSSIILKKKGLQRLVASGATRAVDGGYGYLKDSMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSILISAIFSSYFLGESLNLLGKLGCVICVAGSTVMVIHAPEEEKISTIMEMAAKMKDTGYIVFAVFLLVSCLILIFVVAPRYGQRNILIYITICSVIGAFSVSSSKGLGITIRNFFQGLPVVRHPLPYILSLMLALSISTQVNFLNRALDIFNTSLVFPIYYVFFTTTVMTSSIILFKEWYRMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISRSSLPHMHKNPPATPAPEPSVIRLGDKNVLVDNMELSSTPSPEEKPKVFIAHS", "length": 404, "header": "tr|E1BDX3-1|E1BDX3_BOVIN Isoform 1 of NIPA like domain containing 4 OS=Bos taurus OX=9913 GN=NIPAL4 PE=3 SV=2 CANONICAL=E1BDX3-1" }, "locus": { "chromosome": "7", "start_pos": 69115295, "end_pos": 69101797, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026918.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026918.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026918.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026918.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 365, "start_aa": "Thr", "end_pos": 365, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr365", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532275", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532275", "resource": "KEGG Pathway" }, { "id": "R-BTA-5223345", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "resource": "Reactome", "description": "Miscellaneous transport and binding events" } ], "orthologs": [ { "uniprot_canonical_ac": "B3LFA3-1", "protein_name": "Probable magnesium transporter NIPA2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEEMSPDNIHGVILAVSSSIFIGSSFIIKKKGLKKAGVSGARAGEGGYGYLYEPWWWAGMITMIVGEIANFAAYAFAPAILVTPLGALSIIFSAVLAHFILEEKLHMFGILGCVLCVVGSTTIVLHAPHEQGIESVKQVWHLATEPGFLAYSAVVLVVVLALIFYYEPRYGKTHMIVYVGICSLMGSLTVMSVKAVAIAIKLTFSGMNQFKYFHAWIFIIVVTICCILQINYLNKALDNFNTAVISPVYYVMFTTFTILASMIMFKDWASQSGLQIATELCGFVTILSGTFLLHKTKDMGNSTSLRGSTSHSPRDTPVFINSGSSRSSNSTRPAIL", "length": 336 }, "evidence": [ { "id": "E1BDX3", "url": "https://omabrowser.org/oma/group/E1BDX3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "D3ZA72-1", "protein_name": "NIPA-like domain containing 4", "gene_name": "Nipal4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELRVANSNGSCENGSIVSLYCSSQEVLCQIVRGIGPEEPYNATLITWQERIRKKYGFYIGVGLAFLSCFLIGTSVILKKKGLIRLVATGATRAVNGGYGYLKDPMWWAGFATMSAGEVANFGAYAFAPATVVTPLGALSVLISAVFSSYCLGESLNLLGKLGCVICMAGSTVMVIHAPKEEKITTVAEMASKMKDTGFIVFAVLLVVSCLILIFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLPVVHHPLPYILSLILGLSIIIQVNFLNRALDIFNTSLVFPIYYVFFTTVVVVSSIVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISQISLPHTHKNTTPAPAPEPTVIKLEDKNVLVDNIELASTPSPQQKPKVFMIHS", "length": 406 }, "evidence": [ { "id": "E1BDX3", "url": "https://omabrowser.org/oma/group/E1BDX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QHP8-1", "protein_name": "Magnesium transporter NIPA4 isoform X1", "gene_name": "nipal4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVTMKDIHLPSDSCINGSVIRIFCPTSASICVFDTAVGNTSYSLDNSNKNLTVSTQSLAIDKWSNYNFWTGLTLAVLSAFLIGGSVILKKKALLRLANTGETRAAEGGHGYLKDWLWWGGLLTMGGGEAANFAAYMFAPATVVTPLGALSVLISAVLSSHLFRETMNLLGKLGCMLSVLGSTLMVIHAPEEEEVTTLKEMAEKLLDPGFLVFASILLVTCLILIFYVSPRFGQSNILVYISICSLLGSFTVSSVKGLGIAIRTMFTDTSVVRNPLMWILLLTLIGSIIIQVNYLNKSLDTFNTLLVYPIYYVFFTTVVLSTSVILFKEWGAMSGVDVVGTIGAFLVIVIGVSMLNIFKDLNVCFEDLRSNLCQPLSQESPSKREDKHILIENIETLPPMREEGPRVFIIS", "length": 411 }, "evidence": [ { "id": "E1BDX3", "url": "https://omabrowser.org/oma/group/E1BDX3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q0D2K0-1", "protein_name": "Magnesium transporter NIPA4", "gene_name": "NIPAL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELRVSNTSCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS", "length": 404 }, "evidence": [ { "id": "E1BDX3", "url": "https://omabrowser.org/oma/group/E1BDX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BZF2-1", "protein_name": "Magnesium transporter NIPA4", "gene_name": "Nipal4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELRVANANGSCENGSIVSLYCSSQEVLCQIVRGISPEEPYNATLITWQERVRKKYGFYIGVGLAFLSCFLIGTSVILKKKGLIRLVATGATRAVNGGYGYLKDPMWWAGMATMSAGEVANFGAYAFAPATVVTPLGALSVLISAIFSSYCLGESLNLLGKLGCVICMAGSTVMVIHAPKEEKVTTVAEMASKMKDTGFIVFAVLLVVSCLILIFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLPVVRHPLPYILSLILGLSIIIQVNFLNRALDIFNTSLVFPIYYVFFTTVVVASSIVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDINQISLPHTHKNPTPAPAPEPTVIKLEDKNVLVDNIELASTPSPQQKPKVFMTDS", "length": 406 }, "evidence": [ { "id": "E1BDX3", "url": "https://omabrowser.org/oma/group/E1BDX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "magnesium ion transport", "id": "GO:0015693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015693", "evidence": [ { "database": "UniProtKB", "id": "E1BDX3", "url": "https://www.uniprot.org/uniprotkb/E1BDX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BDX3", "url": "https://www.uniprot.org/uniprotkb/E1BDX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "E1BDX3", "url": "https://www.uniprot.org/uniprotkb/E1BDX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDX3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 365 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE08-1", "uniprot_ac": "E1BE08", "uniprot_id": "E1BE08_BOVIN", "mass": { "chemical_mass": 25694.0, "monoisotopic_mass": 25694.0 }, "refseq": { "ac": "NP_001179249", "name": "citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249" }, "gene_names": [ { "name": "CSKMT", "type": "recommended", "evidence": [ { "id": "E1BE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ] }, { "name": "CSKMT", "type": "synonym", "evidence": [ { "id": "NP_001179249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249" } ] }, { "name": "METTL12", "type": "synonym", "evidence": [ { "id": "NP_001179249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249" } ] } ], "protein_names": [ { "name": "Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#names_and_taxonomy" } ] }, { "name": "Methyltransferase-like protein 12, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#names_and_taxonomy" } ] }, { "name": "citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001179249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249" } ] }, { "name": "methyltransferase like 12", "type": "synonym", "evidence": [ { "id": "NP_001179249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249" } ] } ], "function": [ { "annotation": "Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event.", "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08#function" }, { "database": "UniProtKB", "id": "ARBA00058794", "url": "https://www.uniprot.org/uniprotkb/ARBA00058794#function" }, { "database": "UniProtKB", "id": "A0A3Q1MW24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW24#function" }, { "database": "UniProtKB", "id": "A0AAA9SI34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI34#function" }, { "database": "UniProtKB", "id": "A0AAA9SD21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD21#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSKMT", "url": "https://www.uniprot.org/uniprotkb/E1BE08", "locus": { "chromosome": "29", "start_pos": 40998546, "end_pos": 40987280, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022293", "url": "https://www.ensembl.org/id/ENSBTAG00000022293" } ] } } ], "crossref": [ { "id": "E1BE08", "url": "https://alphafold.ebi.ac.uk/entry/E1BE08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022293", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022293", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512401", "url": "https://www.ncbi.nlm.nih.gov/gene/512401", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512401", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512401", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMQEHIQ", "url": "https://omabrowser.org/oma/group/LMQEHIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BE08", "url": "https://www.orthodb.org/?gene=E1BE08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12176:SF83", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12176:SF83", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9854311", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179249", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "55544", "url": "https://www.rhea-db.org/rhea/55544", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55548", "url": "https://www.rhea-db.org/rhea/55548", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55552", "url": "https://www.rhea-db.org/rhea/55552", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MW24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MW24-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE08-1", "url": "https://www.uniprot.org/uniprotkb/E1BE08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALRRTLHLASLAAGTRRTVAGSLAGSCLADRSLWDKLHAQPRQGSVRTFDWFFGYEEAQGLLLPLLEKSWAACPPRVLDVGCGTSSLCPGLYTKCPHPVDVLGVDFSPVAVAHMNSLLEGGQGQTPLCPGHPESSLHFMQADGQNLQPVASSGSFQLVLDKGTWDAVARGGLPGAYQLLAECLRVLSPQGTLIQFSDEDPDVRLPCLEKGSQGWTVTVQELGPFRGITYFAYVVQGSD", "length": 240, "header": "tr|E1BE08-1|E1BE08_BOVIN Isoform 1 of Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial OS=Bos taurus OX=9913 GN=CSKMT PE=3 SV=1 CANONICAL=E1BE08-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MW24-1", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#A0A3Q1MW24-1", "sequence": { "sequence": "MAALRRTLHLASLAAGTRRTVAGREGGHWEGKLGSSLPNSLVIEIVTLKTPGHMAPILQQFERTGRWVMRVLPSSSGSLAGSCLADRSLWDKLHAQPRQGSVRTFDWFFGYEEAQGLLLPLLEKSWAACPPRVLDVGCGTSSLCPGLYTKCPHPVDVLGVDFSPVAVAHMNSLLEGGQGQTPLCPGHPESSLHFMQADGQNLQPVASSGSFQLVLDKGTWDAVARGGLPGAYQLLAECLRVLSPQGTLIQFSDEDPDVRLPCLEKGSQGWTVTVQELGPFRGITYFAYVVQGSD", "length": 294, "header": "tr|A0A3Q1MW24-1|A0A3Q1MW24_BOVIN Computationally mapped isoform of Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial OS=Bos taurus OX=9913 GN=CSKMT PE=3 SV=1 CANONICAL=E1BE08-1" }, "locus": { "chromosome": "29", "start_pos": 40997793, "end_pos": 40996912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073261.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073261.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059486.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059486.2" } ] } }, { "isoform_ac": "A0AAA9SD21-1", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#A0AAA9SD21-1", "sequence": { "sequence": "MLKLKLQYFGHLMRRVDSLEKTLILGGIGGRRRRGRQRMRWLDGITDSMDVCGATPRAGAAISPLPLPAANNKGHSYGTKFVSAFSFSEAAGLGKLYASFRTADFANLPLDLRPQPEYGRHFHTSFSGRPCRHLRMAALRRTLHLASLAAGTRRTVAGSLAGSCLADRSLWDKLHAQPRQGSVRTFDWFFGYEEAQGLLLPLLEKSWAACPPRVLDVGCGTSSLCPGLYTKCPHPVDVLGVDFSPVAVAHMNSLLEGGQGQTPLCPGHPESSLHFMQADGQNLQPVASSGSFQLVLDKGTWDAVARGGLPGAYQLLAECLRVLSPQGTLIQFSDEDPDVRLPCLEKGSQGWTVTVQELGPFRGITYFAYVVQGSD", "length": 375, "header": "tr|A0AAA9SD21-1|A0AAA9SD21_BOVIN Computationally mapped isoform of Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial OS=Bos taurus OX=9913 GN=CSKMT PE=3 SV=1 CANONICAL=E1BE08-1" }, "locus": { "chromosome": "29", "start_pos": 40997793, "end_pos": 40987479, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112868.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112868.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080214.1" } ] } }, { "isoform_ac": "A0AAA9SI34-1", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#A0AAA9SI34-1", "sequence": { "sequence": "MVCGATPRAGAAISPLPLPAANNKGHSYGTKFVSAFSFSEAAGLGKLYASFRTADFANLPLDLRPQPEYGRHFHTSFSGRPCRHLRMAALRRTLHLASLAAGTRRTVAGSLAGSCLADRSLWDKLHAQPRQGSVRTFDWFFGYEEAQGLLLPLLEKSWAACPPRVLDVGCGTSSLCPGLYTKCPHPVDVLGVDFSPVAVAHMNSLLEGGQGQTPLCPGHPESSLHFMQADGQNLQPVASSGSFQLVLDKGTWDAVARGGLPGAYQLLAECLRVLSPQGTLIQFSDEDPDVRLPCLEKGSQGWTVTVQELGPFRGITYFAYVVQGSD", "length": 326, "header": "tr|A0AAA9SI34-1|A0AAA9SI34_BOVIN Computationally mapped isoform of Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial OS=Bos taurus OX=9913 GN=CSKMT PE=3 SV=1 CANONICAL=E1BE08-1" }, "locus": { "chromosome": "29", "start_pos": 40997793, "end_pos": 40988825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130003.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130003.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084999.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084999.1" } ] } }, { "isoform_ac": "E1BE08-1", "url": "https://www.uniprot.org/uniprotkb/E1BE08/entry#E1BE08-1", "sequence": { "sequence": "MAALRRTLHLASLAAGTRRTVAGSLAGSCLADRSLWDKLHAQPRQGSVRTFDWFFGYEEAQGLLLPLLEKSWAACPPRVLDVGCGTSSLCPGLYTKCPHPVDVLGVDFSPVAVAHMNSLLEGGQGQTPLCPGHPESSLHFMQADGQNLQPVASSGSFQLVLDKGTWDAVARGGLPGAYQLLAECLRVLSPQGTLIQFSDEDPDVRLPCLEKGSQGWTVTVQELGPFRGITYFAYVVQGSD", "length": 240, "header": "tr|E1BE08-1|E1BE08_BOVIN Isoform 1 of Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial OS=Bos taurus OX=9913 GN=CSKMT PE=3 SV=1 CANONICAL=E1BE08-1" }, "locus": { "chromosome": "29", "start_pos": 40997793, "end_pos": 40996912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030134.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030134.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030119.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030119.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512401", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512401", "resource": "KEGG Pathway" }, { "id": "R-BTA-9854311", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "resource": "Reactome", "description": "Maturation of TCA enzymes and regulation of TCA cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A8MUP2-1", "protein_name": "Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial", "gene_name": "CSKMT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH", "length": 240 }, "evidence": [ { "id": "E1BE08", "url": "https://omabrowser.org/oma/group/E1BE08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "I3L7A7-1", "protein_name": "Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial", "gene_name": "CSKMT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALRRTLHVASLAAGTHRALAGSLADSCLADRCLWDKLHAQPRQGSVRTFDWFFGYEEVQGLLLPLLQEARSACPPRVLDVGCGTSNLCTGLYTKCPHPVDVLGVDFSPVALAHMNSLLEGGQGQTPLSPGHLASRLHFMQADAQNLEPVAPSGSFQLVLDKGTWDAVARGGLPGAYKLLSECLRVLSPQGTLIQFSDEDPDVRLPCLEQGSRGWAVTVQELGPFRGITYFAYMVRGCN", "length": 240 }, "evidence": [ { "id": "E1BE08", "url": "https://omabrowser.org/oma/group/E1BE08/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-lysine N-methyltransferase activity", "id": "GO:0016279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016279", "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ], "pmid": "" }, { "name": "S-adenosylmethionine-dependent methyltransferase activity", "id": "GO:0008757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008757", "evidence": [ { "database": "UniProtKB", "id": "E1BE08", "url": "https://www.uniprot.org/uniprotkb/E1BE08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "55544", "name": "", "equation": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "55544", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55544" } ] }, { "id": "55548", "name": "", "equation": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "55548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55548" } ] }, { "id": "55552", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "55552", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55552" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BE08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 240, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BE08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BE08" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE08" }, { "id": "PF08241", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08241" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase type 11", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 195, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE19-1", "uniprot_ac": "E1BE19", "uniprot_id": "E1BE19_BOVIN", "mass": { "chemical_mass": 167893.0, "monoisotopic_mass": 167893.0 }, "refseq": { "ac": "NP_001193338", "name": "transcription factor Gibbin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193338" }, "gene_names": [ { "name": "AHDC1", "type": "recommended", "evidence": [ { "id": "E1BE19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ] }, { "name": "AHDC1", "type": "synonym", "evidence": [ { "id": "NP_001193338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193338" } ] } ], "protein_names": [ { "name": "AT-hook DNA binding motif containing 1", "type": "synonym", "evidence": [ { "id": "E1BE19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE19/entry#names_and_taxonomy" } ] }, { "name": "transcription factor Gibbin", "type": "synonym", "evidence": [ { "id": "NP_001193338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193338" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AHDC1", "url": "https://www.uniprot.org/uniprotkb/E1BE19", "locus": { "chromosome": "2", "start_pos": 125781092, "end_pos": 125715772, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037456", "url": "https://www.ensembl.org/id/ENSBTAG00000037456" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522105", "url": "https://www.ncbi.nlm.nih.gov/gene/522105", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522105", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522105", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TEWAGDK", "url": "https://omabrowser.org/oma/group/TEWAGDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BE19", "url": "https://www.orthodb.org/?gene=E1BE19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15617", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15617", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15617:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15617:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15735", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193338", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE19-1", "url": "https://www.uniprot.org/uniprotkb/E1BE19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPARPPASPPDKAFAHTFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPAGDNSSSSRRHWDNGRATLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPQDSPQPGQGHSPGATAAATGLPPEPEPDGPDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPLQPLADPLGLPSLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGPCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPTGLAAALVEPPPPPPPPPPALPGPVPVPELEPEASQTPVVPPRKGKCRGIRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPVVVAAEAATVATASMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGHAAKAARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGTEWVGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSAAAPAGQAELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGAEPSFQPVLPARQTFPPSRAASYGLTPATSECRAAETFPKLAPPPSAVARSPTTHPPTNTYPPQYGGYGAGQSVFAPAKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFNSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPGFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPSSASGAASGYPSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFSVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL", "length": 1597, "header": "tr|E1BE19-1|E1BE19_BOVIN Isoform 1 of AT-hook DNA binding motif containing 1 OS=Bos taurus OX=9913 GN=AHDC1 PE=4 SV=1 CANONICAL=E1BE19-1" }, "isoforms": [ { "isoform_ac": "E1BE19-1", "url": "https://www.uniprot.org/uniprotkb/E1BE19/entry#E1BE19-1", "sequence": { "sequence": "MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPARPPASPPDKAFAHTFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPAGDNSSSSRRHWDNGRATLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPQDSPQPGQGHSPGATAAATGLPPEPEPDGPDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPLQPLADPLGLPSLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGPCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPTGLAAALVEPPPPPPPPPPALPGPVPVPELEPEASQTPVVPPRKGKCRGIRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPVVVAAEAATVATASMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGHAAKAARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGTEWVGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSAAAPAGQAELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGAEPSFQPVLPARQTFPPSRAASYGLTPATSECRAAETFPKLAPPPSAVARSPTTHPPTNTYPPQYGGYGAGQSVFAPAKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFNSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPGFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPSSASGAASGYPSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFSVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL", "length": 1597, "header": "tr|E1BE19-1|E1BE19_BOVIN Isoform 1 of AT-hook DNA binding motif containing 1 OS=Bos taurus OX=9913 GN=AHDC1 PE=4 SV=1 CANONICAL=E1BE19-1" }, "locus": { "chromosome": "2", "start_pos": 125770422, "end_pos": 125765632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089227.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1023, "start_aa": "Thr", "end_pos": 1023, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1023", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 34, "start_aa": "Thr", "end_pos": 34, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr34", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 98, "start_aa": "Thr", "end_pos": 98, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr98", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:522105", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522105", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A5R3-1", "protein_name": "AT hook, DNA binding motif, containing 1", "gene_name": "Ahdc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPTPAPDNNSLRHWDNGRVNLHPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKPERPNHPLYEPEPEPRDSPQPGQGHGPGATATATGLPPEPEPDGPDYPELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLDPQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKVDSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPPALSGPVPELEPESSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAEAAAVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKAARCSFSDFFEGIGKKKKVVAVAATGVVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGNYAGPPSSALPAQRGLATFPSRGAKGSPVAVGNSGAGTDPSFQPVLPSRQTFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAGQSVFAPAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASAASSSSSSFQPSPENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQPRGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPDLDSKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCRDLPLGQPHYESPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHLASPPATPKADKEPLEMTRPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQTHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL", "length": 1592 }, "evidence": [ { "id": "E1BE19", "url": "https://omabrowser.org/oma/group/E1BE19/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5TGY3-1", "protein_name": "Transcription factor Gibbin", "gene_name": "AHDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHAFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPVGDGSSSRRCWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPRDSPQPGQGHSPGATAAATGLPPEPEPDSTDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPLQPLADPLGLPGLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGHCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPTGLVAALAEPPPPPPPPPPALPGPGPVSVPELKPESSQTPVVSTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPAVVAAEAATVAAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGHAAKSARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSTGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPVLSARQTFPPGRAASYGLTPAASDCRAAETFPKLVPPPSAMARSPTTHPPANTYLPQYGGYGAGQSVFAPTKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFSSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPSFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPTSASAAASGYPSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFIGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGTGLLADFLGRTEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL", "length": 1603 }, "evidence": [ { "id": "E1BE19", "url": "https://omabrowser.org/oma/group/E1BE19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PAL7-1", "protein_name": "Transcription factor Gibbin", "gene_name": "Ahdc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPSPAPDNSSLRHWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERANPHTKSERPSHPLYEPEPEPRDSPQPGQGHGPGAAATATGLPPEPEPDGPDYSELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLDPQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPTLSGPGPVPELEPESSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAEAATVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKAARCSFSDFFEGIGKKKKVVAVAAPGLVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWVGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPSSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPVLPSRQTFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAGQSVFASAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASVASSSSSSFQPSPENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHGSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFSQPVGGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQPRGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAAELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL", "length": 1594 }, "evidence": [ { "id": "E1BE19", "url": "https://omabrowser.org/oma/group/E1BE19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "pmid": "" }, { "name": "promoter-enhancer loop anchoring activity", "id": "GO:0140585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140585", "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mesoderm formation", "id": "GO:0001707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707", "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "pmid": "" }, { "name": "skin morphogenesis", "id": "GO:0043589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043589", "evidence": [ { "database": "UniProtKB", "id": "E1BE19", "url": "https://www.uniprot.org/uniprotkb/E1BE19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1142, "end_pos": 1144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1214, "end_pos": 1216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 745, "end_pos": 747, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BE19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE19" }, { "id": "PF15735", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15735" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4683", "eco_id": "ECO_0000259", "start_pos": 582, "end_pos": 639, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 34, 98, 1023 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1037, "end_pos": 1039 }, { "start_pos": 103, "end_pos": 105 }, { "start_pos": 1142, "end_pos": 1144 }, { "start_pos": 1214, "end_pos": 1216 }, { "start_pos": 487, "end_pos": 489 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 745, "end_pos": 747 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE26-1", "uniprot_ac": "E1BE26", "uniprot_id": "E1BE26_BOVIN", "mass": { "chemical_mass": 38556.0, "monoisotopic_mass": 38556.0 }, "refseq": { "ac": "NP_001192447", "name": "SH2 domain-containing adapter protein D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192447" }, "gene_names": [ { "name": "SHD", "type": "recommended", "evidence": [ { "id": "E1BE26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE26" } ] }, { "name": "SHD", "type": "synonym", "evidence": [ { "id": "NP_001192447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192447" } ] } ], "protein_names": [ { "name": "SH2 domain-containing adapter protein D", "type": "recommended", "evidence": [ { "id": "E1BE26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE26/entry#names_and_taxonomy" } ] }, { "name": "SH2 domain-containing adapter protein D", "type": "synonym", "evidence": [ { "id": "NP_001192447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192447" } ] } ], "function": [ { "annotation": "May function as an adapter protein.", "evidence": [ { "database": "UniProtKB", "id": "E1BE26", "url": "https://www.uniprot.org/uniprotkb/E1BE26#function" }, { "database": "UniProtKB", "id": "ARBA00057390", "url": "https://www.uniprot.org/uniprotkb/ARBA00057390#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE26", "url": "https://www.uniprot.org/uniprotkb/E1BE26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHD", "url": "https://www.uniprot.org/uniprotkb/E1BE26", "locus": { "chromosome": "7", "start_pos": 19783236, "end_pos": 19791403, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039696", "url": "https://www.ensembl.org/id/ENSBTAG00000039696" } ] } } ], "crossref": [ { "id": "E1BE26", "url": "https://alphafold.ebi.ac.uk/entry/E1BE26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039696", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039696", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10390", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10390", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518715", "url": "https://www.ncbi.nlm.nih.gov/gene/518715", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518715", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518715", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKEFRRP", "url": "https://omabrowser.org/oma/group/AKEFRRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BE26", "url": "https://www.orthodb.org/?gene=E1BE26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15127:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15127:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192447", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TD09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE26", "url": "https://www.uniprot.org/uniprotkb/E1BE26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE26-1", "url": "https://www.uniprot.org/uniprotkb/E1BE26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1U7", "url": "https://www.uniprot.org/uniprotkb/F1N1U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1U7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1U7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSSGGPGDSKGPGDAKYDSPKHRLIKVEAVDIARAKVLLGSPGEESKVDTEYSDPFDAQPHPPPPDDGYMEPYDAQRVMSELPCRRVQLYDTPYEEQDQELGDGPPSGQKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPDWERTSGSAKELRRPPPRSPQPAERVDPTLPLEKQPWFHGLLSRADAENLLSLCKEGSYLVRLSESSPQDCSLSLRSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQTP", "length": 341, "header": "tr|E1BE26-1|E1BE26_BOVIN Isoform 1 of SH2 domain-containing adapter protein D OS=Bos taurus OX=9913 GN=SHD PE=4 SV=3 CANONICAL=E1BE26-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TD09-1", "url": "https://www.uniprot.org/uniprotkb/E1BE26/entry#A0AAA9TD09-1", "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSSGGPGDSKGPGDAKYDSPKHRLIKVEAVDIARAKVLLGSPGEESKVDTEYSDPFDAQPHPPPPDDGYMEPYDAQRVMSELPCRRVQLYDTPYEEQDQELGDGPPSGQKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPDWERTSGSAKELRRPPPRSPQPAERVDPTLPLEKQPSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQTP", "length": 301, "header": "tr|A0AAA9TD09-1|A0AAA9TD09_BOVIN Computationally mapped isoform of Src homology 2 domain containing transforming protein D OS=Bos taurus OX=9913 GN=SHD PE=4 SV=1 CANONICAL=E1BE26-1" }, "locus": { "chromosome": "7", "start_pos": 19790932, "end_pos": 19783442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094027.1" } ] } }, { "isoform_ac": "E1BE26-1", "url": "https://www.uniprot.org/uniprotkb/E1BE26/entry#E1BE26-1", "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSSGGPGDSKGPGDAKYDSPKHRLIKVEAVDIARAKVLLGSPGEESKVDTEYSDPFDAQPHPPPPDDGYMEPYDAQRVMSELPCRRVQLYDTPYEEQDQELGDGPPSGQKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPDWERTSGSAKELRRPPPRSPQPAERVDPTLPLEKQPWFHGLLSRADAENLLSLCKEGSYLVRLSESSPQDCSLSLRSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQTP", "length": 341, "header": "tr|E1BE26-1|E1BE26_BOVIN Isoform 1 of SH2 domain-containing adapter protein D OS=Bos taurus OX=9913 GN=SHD PE=4 SV=3 CANONICAL=E1BE26-1" }, "locus": { "chromosome": "7", "start_pos": 19790932, "end_pos": 19783442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061173.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061173.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053657.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053657.3" } ] } }, { "isoform_ac": "F1N1U7-1", "url": "https://www.uniprot.org/uniprotkb/E1BE26/entry#F1N1U7-1", "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSSGGPGDSKGPGDAKYDSPKHRLIKVEAVDIARAKVLLGSPGEEEIRVPSLRQEDPLEKEMATHSSILTWKIPWSEEPAW", "length": 136, "header": "tr|F1N1U7-1|F1N1U7_BOVIN Computationally mapped isoform of Src homology 2 domain containing transforming protein D OS=Bos taurus OX=9913 GN=SHD PE=4 SV=1 CANONICAL=E1BE26-1" }, "locus": { "chromosome": "7", "start_pos": 19790932, "end_pos": 19789868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026881.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026881.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026881.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026881.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 22, "start_aa": "Thr", "end_pos": 22, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:518715", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518715", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AE76-1", "protein_name": "Src homology 2 domain containing transforming protein D", "gene_name": "SHD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKWLREYLGRGARRSPPRPPQPDYSGGERRPPGTGSGTASPRHRLVRVGGPGRLEQGPNESEYSEPFEQNAAPEGSNEDPREAAGRPRHGGGQRVRGQRDPRLYDTPCEEWEKVGEGAGGGAARESRLPRDDERPADEYDQPWEWKKDHISRAFAVQFESPERSPSLSRQPPRPPRPPPGTRPLCPPSPGHVDTSLPLEKQAWYHGPIGRAGAETLLALCREGSFLVRDCETSPDDYSLSLRYAVGRPYGAGVARRAKGRPHPYRAHAAPRVPHSAPQEQPRLRAREADADAGAALRVGARGGRLPLRARRCAALHGASAARPRRPAPLPALPRGCAAPLSPTAPGIPPERSH", "length": 354 }, "evidence": [ { "id": "E1BE26", "url": "https://omabrowser.org/oma/group/E1BE26/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S7M3-1", "protein_name": "SH2 domain-containing adapter protein D", "gene_name": "SHD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSAGPGDSKGPGDAKYDSPKHRLIKVEAVDMARAKVLLGSACEESEVDAEYSDPFDAQPHPPPPDNGYMEPYDAQRIVSELPCRGVQLYDTPYEEQDQEPGDETPSGRKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPEWERTSGSAKELRRPPHRSPQPAERVDPALPLEKQPWFHGPLSRADAENLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQSP", "length": 340 }, "evidence": [ { "id": "E1BE26", "url": "https://omabrowser.org/oma/group/E1BE26/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R864-1", "protein_name": "SH2 domain-containing adapter protein D", "gene_name": "Shd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKWLRDYLNLGSRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDSNGRPESEITESSDPKYNSPRHRLIKVEAVNLARAKTLLGSLGEEPEADTEYSDPFDAQPQPPAPNNGYMEPYDARNISSEQPSRAVQLYDTPYEEQDMKPEDGGSSGQSRRPLEDERPADEYDQPWEWKKDHISRAFAVQFHGPDWERTPCSTKEPWRPQPAERVDTALALEKQPWFHGPLSRVEAENLLSLCKEGSYLVRLSETRAQDCILSLRSNQGSMHLKFAKTRENQVVLGQHSGPFPSVPELVLHYSARPLPVQGIEHLALLYPVTSSQSSQGPCTLAARPEKGQGDP", "length": 343 }, "evidence": [ { "id": "E1BE26", "url": "https://omabrowser.org/oma/group/E1BE26/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O88834-1", "protein_name": "SH2 domain-containing adapter protein D", "gene_name": "Shd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKWLRDYLNLGSRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDSNGRAEPEVTGSGDPKYNSPRHRLIKVEAADMARAKALLGSPGEEPEAETEYSDPFDAQPQPPAPNSGYMEPYDARSVSSEQPSRAVQLYDTPYEEQATKPEDGGSSGQSRRPLEDERPADEYDQPWEWKKDHISRAFAVQFDGPDWERTPCSTKEPWRPQPAERVDTALALEKQPWFHGPLSRAEAENLLSLCKEGSYLVRLSETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIPELVLHYSARPLPVQGAEHLALLYPVTSSQSSQGPCTLAAKPERGQGDP", "length": 343 }, "evidence": [ { "id": "E1BE26", "url": "https://omabrowser.org/oma/group/E1BE26/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96IW2-1", "protein_name": "SH2 domain-containing adapter protein D", "gene_name": "SHD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPDDGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP", "length": 340 }, "evidence": [ { "id": "E1BE26", "url": "https://omabrowser.org/oma/group/E1BE26/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "E1BE26", "url": "https://www.uniprot.org/uniprotkb/E1BE26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BE26-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BE26-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BE26" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BE26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE26" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 241, "end_pos": 336, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 22 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE71-1", "uniprot_ac": "E1BE71", "uniprot_id": "E1BE71_BOVIN", "mass": { "chemical_mass": 147488.0, "monoisotopic_mass": 147488.0 }, "refseq": { "ac": "XP_059739044", "name": "roundabout homolog 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739044" }, "gene_names": [ { "name": "ROBO3", "type": "recommended", "evidence": [ { "id": "E1BE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ] }, { "name": "ROBO3", "type": "synonym", "evidence": [ { "id": "XP_059739044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739044" } ] } ], "protein_names": [ { "name": "Roundabout homolog 3", "type": "recommended", "evidence": [ { "id": "E1BE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE71/entry#names_and_taxonomy" } ] }, { "name": "roundabout homolog 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739044" } ] } ], "function": [ { "annotation": "Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself.", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71#function" }, { "database": "UniProtKB", "id": "ARBA00054174", "url": "https://www.uniprot.org/uniprotkb/ARBA00054174#function" }, { "database": "UniProtKB", "id": "A0A3Q1NBZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBZ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ROBO3", "url": "https://www.uniprot.org/uniprotkb/E1BE71", "locus": { "chromosome": "29", "start_pos": 28349792, "end_pos": 28330522, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004355", "url": "https://www.ensembl.org/id/ENSBTAG00000004355" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337359", "url": "https://www.ncbi.nlm.nih.gov/gene/100337359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12231:SF236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12231:SF236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739044", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739044", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE71-1", "url": "https://www.uniprot.org/uniprotkb/E1BE71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRYLLKTLLQMNLFADSLGGDISNSSDLLFGFNSSVAALNQSLLPPGDPSLNGSRIGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECMPPRGHPEPSVSWKKDGVRLKEEEGRITIRGGKLMMSHTFKSDAGMYVCVASNMAGERESGAAKLVVLERPSFLRRPVNQVVLAGAPVDFPCEVQGDPPPRLRWRKEDGELPTGRYEIQSDHSLQIGRVSAEDEGTYTCVAENSVGRAEASGSLIVHVPPQLVTQPQDQMAAPGDSVAFQCETKGNPPPAIFWQKEGSQALLFPSQSLQPTGRFSVSPRGQLNITEVQSRDAGYYVCQAVSVAGSVLAKALLEVKGASLEGLPPIILQGPANQTLALGSSVWLPCRVSGNPQPSVQWKKDGQWLQGDDVQLSVMANGTLYIASVQEGHMGFYSCVAKSSTGEAAWSGWLRRREDWGATPDPLAEPSTPPGPPSQPVVTEITKNSITLTWKPNPQAGATATSYVIEAFSHASGNTWRTVADGVQLETHTVSGLQPSTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWKGQQGLAEVAVRLEEPVVLGPRTLQVSWTVDGPIQLVQGFRVSWRVAGPDGGSWSVLDLPYPSQQSTVLRGLPPGTQVQIKVQAQGQEELGAESPLVTRSIPEEAPSGPPQGVAVALGGEGNSSITVSWEPPLPSQQNGVIEEYQIWCLGNESRFHLNRSAAGWARSAVLRGLLPGLLYRTQVAAATSAGVGVASAPVSVQLPSPPELEPGLEAGPGLAERLARVLREPAFLAGSGAACGALLLGLCAALYRRRRQRKELSHYTASFAYTPAVSFPHSEGLSAASSRPPMGLGPAPYPWLADSWPHSSRSPSAQDPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAASAEGPVYSTIDPAGEELQTFHGGFPPHPSGDPGTWSPYAPPEWSQGDSGARGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSDPEEWCPPMPERSHAAEPSSGGGCLVPPSRGETPSPTPSYGQQSTATLTPSPPDPPQPPTDLPHLHQMPRRVPIGPSSPLSVSQPTLSSHEGRPAGLGAGPSGPHHSPSPVPATAGSAPGRARPVPGELTPPLHGPRARIRKKPKAFPYRREHSPGDLPPPPLPPPEEEASWALGLRAAGSMSSLEREREHSGERRLVQATPLGAQRRPHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSGSSRGSRGPGRSRSRSRSQSQRPGQKRGEEPR", "length": 1385, "header": "tr|E1BE71-1|E1BE71_BOVIN Isoform 1 of Roundabout homolog 3 OS=Bos taurus OX=9913 GN=ROBO3 PE=3 SV=4 CANONICAL=E1BE71-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NBZ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BE71/entry#A0A3Q1NBZ6-1", "sequence": { "sequence": "MLRYLLKTLLQMNLFADSLGGDISNSSDLLFGFNSSVAALNQSLLPPGDPSLNGSRIGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECMPPRGHPEPSVSWKKDGVRLKEEEGRITIRGGKLMMSHTFKSDAGMYVCVASNMAGERESGAAKLVVLERPSFLRRPVNQVVLAGAPVDFPCEVQGDPPPRLRWRKEDGELPTGRYEIQSDHSLQIGRVSAEDEGTYTCVAENSVGRAEASGSLIVHVPPQLVTQPQDQMAAPGDSVAFQCETKGNPPPAIFWQKEGSQALLFPSQSLQPTGRFSVSPRGQLNITEVQSRDAGYYVCQAVSVAGSVLAKALLEVKGASLEGLPPIILQGPANQTLALGSSVWLPCRVSGNPQPSVQWKKDGQWLQGDDVQLSVMANGTLYIASVQEGHMGFYSCVAKSSTGEAAWSGWLRRREDWGATPDPLAEPSTPPGPPSQPVVTEITKNSITLTWKPNPQAGATATSYVIEAFSHASGNTWRTVADGVQLETHTVSGLQPSTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWKGQQGLAEVAVRLEEPVVLGPRTLQVSWTVDGPIQLVQGFRVSWRVAGPDGGSWSVLDLPYPSQQSTVLRGLPPGTQVQIKVQAQGQEELGAESPLVTRSIPEEAPSGPPQGVAVALGGEGNSSITVSWEPPLPSQQNGVIEEYQIWCLGNESRFHLNRSAAGWARSAVLRGLLPGLLYRTQVAAATSAGVGVASAPVSVQLPSPPELEPGLEAGPGLAERLARVLREPAFLAGSGAACGALLLGLCAALYRRRRQRKELSHYTASFAYTPAVSFPHSEGLSAASSRPPMGLGPAPYPWLADSWPHSSRSPSAQDPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAASAEGPVYSTIDPAGEELQTFHGGFPPHPSGDPGTWSPYAPPEWSQGDSGARGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSDPEEWCPPMPERSHAAEPSSGRARPVPGELTPPLHGPRARIRKKPKAFPYRREHSPGDLPPPPLPPPEEEASWALGLRAAGSMSSLEREREHSGERRLVQATPLGAQRRPHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSGSSRGSRGPGRSRSRSRSQSQRPGQKRGEEPR", "length": 1286, "header": "tr|A0A3Q1NBZ6-1|A0A3Q1NBZ6_BOVIN Computationally mapped isoform of Roundabout homolog 3 OS=Bos taurus OX=9913 GN=ROBO3 PE=3 SV=2 CANONICAL=E1BE71-1" }, "locus": { "chromosome": "29", "start_pos": 28349157, "end_pos": 28330721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070823.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070823.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068876.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068876.2" } ] } }, { "isoform_ac": "E1BE71-1", "url": "https://www.uniprot.org/uniprotkb/E1BE71/entry#E1BE71-1", "sequence": { "sequence": "MLRYLLKTLLQMNLFADSLGGDISNSSDLLFGFNSSVAALNQSLLPPGDPSLNGSRIGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECMPPRGHPEPSVSWKKDGVRLKEEEGRITIRGGKLMMSHTFKSDAGMYVCVASNMAGERESGAAKLVVLERPSFLRRPVNQVVLAGAPVDFPCEVQGDPPPRLRWRKEDGELPTGRYEIQSDHSLQIGRVSAEDEGTYTCVAENSVGRAEASGSLIVHVPPQLVTQPQDQMAAPGDSVAFQCETKGNPPPAIFWQKEGSQALLFPSQSLQPTGRFSVSPRGQLNITEVQSRDAGYYVCQAVSVAGSVLAKALLEVKGASLEGLPPIILQGPANQTLALGSSVWLPCRVSGNPQPSVQWKKDGQWLQGDDVQLSVMANGTLYIASVQEGHMGFYSCVAKSSTGEAAWSGWLRRREDWGATPDPLAEPSTPPGPPSQPVVTEITKNSITLTWKPNPQAGATATSYVIEAFSHASGNTWRTVADGVQLETHTVSGLQPSTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWKGQQGLAEVAVRLEEPVVLGPRTLQVSWTVDGPIQLVQGFRVSWRVAGPDGGSWSVLDLPYPSQQSTVLRGLPPGTQVQIKVQAQGQEELGAESPLVTRSIPEEAPSGPPQGVAVALGGEGNSSITVSWEPPLPSQQNGVIEEYQIWCLGNESRFHLNRSAAGWARSAVLRGLLPGLLYRTQVAAATSAGVGVASAPVSVQLPSPPELEPGLEAGPGLAERLARVLREPAFLAGSGAACGALLLGLCAALYRRRRQRKELSHYTASFAYTPAVSFPHSEGLSAASSRPPMGLGPAPYPWLADSWPHSSRSPSAQDPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAASAEGPVYSTIDPAGEELQTFHGGFPPHPSGDPGTWSPYAPPEWSQGDSGARGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSDPEEWCPPMPERSHAAEPSSGGGCLVPPSRGETPSPTPSYGQQSTATLTPSPPDPPQPPTDLPHLHQMPRRVPIGPSSPLSVSQPTLSSHEGRPAGLGAGPSGPHHSPSPVPATAGSAPGRARPVPGELTPPLHGPRARIRKKPKAFPYRREHSPGDLPPPPLPPPEEEASWALGLRAAGSMSSLEREREHSGERRLVQATPLGAQRRPHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSGSSRGSRGPGRSRSRSRSQSQRPGQKRGEEPR", "length": 1385, "header": "tr|E1BE71-1|E1BE71_BOVIN Isoform 1 of Roundabout homolog 3 OS=Bos taurus OX=9913 GN=ROBO3 PE=3 SV=4 CANONICAL=E1BE71-1" }, "locus": { "chromosome": "29", "start_pos": 28349157, "end_pos": 28330721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005697.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005697.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005697.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005697.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1145, "start_aa": "Thr", "end_pos": 1145, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1145", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" }, { "name": "axon midline choice point recognition", "id": "GO:0016199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016199", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" }, { "name": "commissural neuron axon guidance", "id": "GO:0071679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071679", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BE71", "url": "https://www.uniprot.org/uniprotkb/E1BE71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1348, "end_pos": 1350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 784, "end_pos": 786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 813, "end_pos": 815, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE71" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 558, "end_pos": 652, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE71" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 160, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1145 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1348, "end_pos": 1350 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 25, "end_pos": 27 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 410, "end_pos": 412 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 503, "end_pos": 505 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 784, "end_pos": 786 }, { "start_pos": 813, "end_pos": 815 }, { "start_pos": 820, "end_pos": 822 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BE87-1", "uniprot_ac": "E1BE87", "uniprot_id": "E1BE87_BOVIN", "mass": { "chemical_mass": 92696.0, "monoisotopic_mass": 92696.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC87", "type": "recommended", "evidence": [ { "id": "E1BE87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 87", "type": "recommended", "evidence": [ { "id": "E1BE87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE87/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87#function" }, { "database": "UniProtKB", "id": "ARBA00057282", "url": "https://www.uniprot.org/uniprotkb/ARBA00057282#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC87", "url": "https://www.uniprot.org/uniprotkb/E1BE87", "locus": { "chromosome": "29", "start_pos": 44624951, "end_pos": 44628630, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004342", "url": "https://www.ensembl.org/id/ENSBTAG00000004342" } ] } } ], "crossref": [ { "id": "E1BE87", "url": "https://alphafold.ebi.ac.uk/entry/E1BE87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004342", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004342", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR037383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BE87", "url": "https://www.orthodb.org/?gene=E1BE87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16078:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16078:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03999", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03999", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE87-1", "url": "https://www.uniprot.org/uniprotkb/E1BE87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPYKLDPEFQRIYHRLLRPLSLFPRRTTRTASQEHLSQEVPMLLPLPVPRLTAELVCRQVAERLTKSGLEARAPHKVRLRFTEVILDELKCGWQEPPTELGMSHLNNQRLRKRLLIYVLLSCEQLFVRYLHLQKLMSTSAVVFTESATLTRLAASLARDCTVFLTGPDVYRSLLSDFLALLKEEQARVSAPRLRAAGLGAYRLFQVPWHHITGVTQVPHFNLSLNYLIQLSRPRDLVSEPEKDPMKELKSIPQLKKKKPLRWLSSMQKRRESTFTSQIASLPGTSVAPRSRAPPTSHLPLYSQLQRGQSMPSLREGWRLADELGLPPLSPRPLTPLVLVAESKPELARDTVAEDLKQMMKHMQLGWSQYSPLDSGLPPLLGALTYRPATTHHLEELQRKLNSLEEQEASEHRGLQSPKPPPLEPQPVTVTLKLKNQMVQIAAVQVSGRNFLDSFHIEPAGVLYNHLAGELEPKLIEQMDIDRTFGSSIREVYKELMSRVSNNHFTFDQGPLVEPAANKDWWSNRARWLNWWKSTLSVGDYFKYLTTQETDFLHVIFQMYEEEGPVETVAPIKESIKIQHPPPLLEDDEPDFVPGEWDWDTVLEHRLETKSSLLEDSHKILSLQKRLERVWSMLDVPEKDRLDMAIKYSSNARLRQLPALVSAWERALQPIQLREILLGRLEWFERQASDPNRFFQKTDVGLSRFLEENQIRGRLQRKLSMVEAPLVPLLEEIELVFGEPVTFKGRRYLDKMKHDKVEMLYWLQQQRRVRHLTRAKRASHQSVLSRKLSSQPLVAPGNTPITL", "length": 803, "header": "tr|E1BE87-1|E1BE87_BOVIN Isoform 1 of Coiled-coil domain-containing protein 87 OS=Bos taurus OX=9913 GN=CCDC87 PE=3 SV=3 CANONICAL=E1BE87-1" }, "isoforms": [ { "isoform_ac": "E1BE87-1", "url": "https://www.uniprot.org/uniprotkb/E1BE87/entry#E1BE87-1", "sequence": { "sequence": "MEPYKLDPEFQRIYHRLLRPLSLFPRRTTRTASQEHLSQEVPMLLPLPVPRLTAELVCRQVAERLTKSGLEARAPHKVRLRFTEVILDELKCGWQEPPTELGMSHLNNQRLRKRLLIYVLLSCEQLFVRYLHLQKLMSTSAVVFTESATLTRLAASLARDCTVFLTGPDVYRSLLSDFLALLKEEQARVSAPRLRAAGLGAYRLFQVPWHHITGVTQVPHFNLSLNYLIQLSRPRDLVSEPEKDPMKELKSIPQLKKKKPLRWLSSMQKRRESTFTSQIASLPGTSVAPRSRAPPTSHLPLYSQLQRGQSMPSLREGWRLADELGLPPLSPRPLTPLVLVAESKPELARDTVAEDLKQMMKHMQLGWSQYSPLDSGLPPLLGALTYRPATTHHLEELQRKLNSLEEQEASEHRGLQSPKPPPLEPQPVTVTLKLKNQMVQIAAVQVSGRNFLDSFHIEPAGVLYNHLAGELEPKLIEQMDIDRTFGSSIREVYKELMSRVSNNHFTFDQGPLVEPAANKDWWSNRARWLNWWKSTLSVGDYFKYLTTQETDFLHVIFQMYEEEGPVETVAPIKESIKIQHPPPLLEDDEPDFVPGEWDWDTVLEHRLETKSSLLEDSHKILSLQKRLERVWSMLDVPEKDRLDMAIKYSSNARLRQLPALVSAWERALQPIQLREILLGRLEWFERQASDPNRFFQKTDVGLSRFLEENQIRGRLQRKLSMVEAPLVPLLEEIELVFGEPVTFKGRRYLDKMKHDKVEMLYWLQQQRRVRHLTRAKRASHQSVLSRKLSSQPLVAPGNTPITL", "length": 803, "header": "tr|E1BE87-1|E1BE87_BOVIN Isoform 1 of Coiled-coil domain-containing protein 87 OS=Bos taurus OX=9913 GN=CCDC87 PE=3 SV=3 CANONICAL=E1BE87-1" }, "locus": { "chromosome": "29", "start_pos": 44628525, "end_pos": 44625955, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005681.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005681.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005681.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005681.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of acrosome reaction", "id": "GO:2000344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000344", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "pmid": "" }, { "name": "positive regulation of fertilization", "id": "GO:1905516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905516", "evidence": [ { "database": "UniProtKB", "id": "E1BE87", "url": "https://www.uniprot.org/uniprotkb/E1BE87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BE87-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 803, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BE87-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BE87" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEA6-1", "uniprot_ac": "E1BEA6", "uniprot_id": "E1BEA6_BOVIN", "mass": { "chemical_mass": 211604.0, "monoisotopic_mass": 211604.0 }, "refseq": { "ac": "NP_001071527", "name": "cation channel sperm-associated targeting subunit tau", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" }, "gene_names": [ { "name": "C2CD6", "type": "recommended", "evidence": [ { "id": "E1BEA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEA6" } ] }, { "name": "ALS2CR11", "type": "synonym", "evidence": [ { "id": "NP_001071527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" } ] }, { "name": "C2CD6", "type": "synonym", "evidence": [ { "id": "NP_001071527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" } ] } ], "protein_names": [ { "name": "C2 calcium dependent domain containing 6", "type": "synonym", "evidence": [ { "id": "E1BEA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEA6/entry#names_and_taxonomy" } ] }, { "name": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11", "type": "synonym", "evidence": [ { "id": "NP_001071527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" } ] }, { "name": "amyotrophic lateral sclerosis 2 chromosome region candidate 11", "type": "synonym", "evidence": [ { "id": "NP_001071527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" } ] }, { "name": "cation channel sperm-associated targeting subunit tau", "type": "synonym", "evidence": [ { "id": "NP_001071527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEA6", "url": "https://www.uniprot.org/uniprotkb/E1BEA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C2CD6", "url": "https://www.uniprot.org/uniprotkb/E1BEA6", "locus": { "chromosome": "2", "start_pos": 90045394, "end_pos": 90168893, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017436", "url": "https://www.ensembl.org/id/ENSBTAG00000017436" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017436", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017436", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616081", "url": "https://www.ncbi.nlm.nih.gov/gene/616081", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616081", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616081", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DIYKRRN", "url": "https://omabrowser.org/oma/group/DIYKRRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEA6", "url": "https://www.orthodb.org/?gene=E1BEA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21665", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21665", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21665:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21665:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071527", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S944", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S944", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S944-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S944-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEA6", "url": "https://www.uniprot.org/uniprotkb/E1BEA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPQDMEKVSNAEDNHNRRVHSLYTAPLFQRISQTNLENMQARGSEFSSTAWNVQGRDKPSNLSKVESKEGPGYRLLNMLRKTLKGSENKAPEVTHEAPSLVPFGDVVGCLAIHIRNCKHFTPKIISQHYSNLFIRISINNVVKCTKTCSLLSQNTEKDFMITFDEVKYFSVQVPRRQDDEKNNIRLELMQHDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYGNFGYGFSHQLKPLQKIIKPSMFMDIAPPPERTDPVTNVIIPQPIAYPAFLSPDLNVTVGVPATSQSNQPSVVQLEKLQQQPRERLEKMKKEYRHLSTWAEKASYLEGLLTPGLEHKEPKESNINEIPESQLEERPTDTVTSGVSLIKEEAETIPSELLDNDDKKGLSLPTLNQSSKDDSSVVAPKTDMPSKETDTPLSTIPRLSITEENQIPPLEEHQQEAMPVKKMKNLFFLPEEKLKDRYPSLLKTDLHPSESSPYCCTKENLNRPCSLDELMQDKACGQKNTNRKGKSVVFSPKEYISPCFKPEYTEFKPAYQKFNIKNGFDPFLRNINNKMSVQKRKDQDMLKCRNILSAEIIEHEDQDPPYPTHSKTSRPASKTWPHNLDIISIKALDTKNNLAGDVGITTVKTSHPMNNVAHDPGIITIKTLDTKNNLAHHSSITTIKTLDAKNMLQEKLPHVSLPNFEGDSSVTGKVNVHKCRLSKSLSLTSHIENLKQSMVLKSILSKNLQDLSDRLFSTPGISMDPEARKKSYSSPLLVIHDEQPSSLEDKVFEKSQDLSNWHSEGGILNSKSLLSQIIKNIPPDSLSEGRPGNSPEAEEEPVSEKHLQPGEIDFPTKKKSSFKKKHSKSEISSSKPDLNSLVYDYVIKQIFTAPIFSELAKGVKEASETQIDSQRQLPTAWESSLSSSVLVPHYEESNNEIEFPPANSVISQIIQAFPVDTLLESGIIKVIELDQEYQKGFLLDTETAFAEEKPKDSTEEYSEIRGKAEPLSDQNSAIIHQETTSSFKRVEFIDKGQNTSPHDSKYQSTPDKKSDLPSNNGQRLDREENDTSSTLENLCTSLTGKLNDSDVIMLKSFLKNIFNFFFKYNQSENRPPEKELERLIQHPFQNKTEDLEEIEENFDTADKLDRKPVLNPKLRIFLEELSESEIKNLKSELSKHVQHYLVEKLSESGHITKEDLPKIYQNLYLMNEKVEPKGQNIFLEKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLNEVLQNYFLKNLSDNSLFKETESDPMCSKVSSLRAQSASVSFQELGQDTSSRSFGSRLEINMKYPLSKSLQSYLIALSENEILDLKADLSKHLQSLFIEKLSKSGLITERQLKGISQHINLVNFSSTPLKCIKPDLSLRDENQFVAEHSDKQNKYSKIAQKTTLQKAPEERLVETELTKKEEKEVFSLENIKENPPIIQEQKRHSQEAKILRSIKVKPCSNKNTQVIPLNKSSERLIDTVPKKKKKEHGFMQFPHEENFEFKTESQDQHNWNGKSKITQSKACFEKTLKMKSLDKKDHCNTYKLMVQEKPEALLSPYQRIPNCKMPNGDEEYVNKFTFPSRRNNNLTCLNSEAGEKSKLEDQYCQRLKGNNNNNKKQHLEIFTHYKEEIQTLYTKPNELCNEKYAWVPESQLLKILIAEKNSKPSLFPEVLKRENLKPKVRKERDRVSKQKKSFNKIDSVLPTTPPSTGIHLRKSVPRTLLHWTARRTTHDCSDRFEELHVTSFKHLENAKSRARLLEKSPDDSHNQFKRFARPYTAPEVNKRGESYTGKFTSPRMVSAGLVHINDSIPEYEIHKMRPKKKIKREY", "length": 1847, "header": "tr|E1BEA6-1|E1BEA6_BOVIN Isoform 1 of C2 calcium dependent domain containing 6 OS=Bos taurus OX=9913 GN=C2CD6 PE=4 SV=2 CANONICAL=E1BEA6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S944-1", "url": "https://www.uniprot.org/uniprotkb/E1BEA6/entry#A0AAA9S944-1", "sequence": { "sequence": "MEPPQDMEKVSNAEDNHNRRVHSLYTAPLFQRISQTNLENMQARGSEFSSTAWNVQGRDKPSNLSKVESKEGPGYRLLNMLRKTLKGSENKAPEVTHEAPSLVPFGDVVGCLAIHIRNCKHFTPKIISQHYSNLFIRISINNVVKCTKTCSLLSQNTEKDFMITFDEVKYFSVQVPRRQDDEKNNIRLELMQHDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYGNFGYGFSHQLKPLQKIIKPSMFMDIAPPPERTDPVTNVIIPQPIAYPAFLSPDLNVTVGVPATSQSNQPSVVQLEKLQQQPRERLEKMKKEYRHLSTWAEKASYLEGLLTPGLEHKEPKESNINEIPESQLEERPTDTVTSGGFLTKRIH", "length": 394, "header": "tr|A0AAA9S944-1|A0AAA9S944_BOVIN Computationally mapped isoform of C2 calcium dependent domain containing 6 OS=Bos taurus OX=9913 GN=C2CD6 PE=4 SV=1 CANONICAL=E1BEA6-1" }, "locus": { "chromosome": "2", "start_pos": 90168867, "end_pos": 90052487, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123402.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123402.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082589.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082589.1" } ] } }, { "isoform_ac": "A0AAA9T2L2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEA6/entry#A0AAA9T2L2-1", "sequence": { "sequence": "MEPPQDMEKVSNAEDNHNRRVHSLYTAPLFQRISQTNLENMQARGSEFSSTAWNVQGRDKPSNLSKVESKEGPGYRLLNMLRKTLKGSENKAPEVTHEAPSLVPFGDVVGCLAIHIRNCKHFTPKIISQHYSNLFIRISINNVVKCTKTCSLLSQNTEKDFMITFDEVKYFSVQVPRRQDDEKNNIRLELMQHDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYGNFGYGFSHQLKPLQKIIKPSMFMDIAPPPERTDPVTNVIIPQPIAYPAFLSPDLNVTVGVPATSQSNQPSVVQLEKLQQQPRERLEKMKKEYRHLSTWAEKASYLEGLLTPGLEHKEPKESNINEIPESQLEERPTDTVTSGVSLIKEEAETIPSELLDNDDKKGLSLPTLNQSSKDDSSVVAPKTDMPSKETDTPLSTIPRLSITEENQIPPLEEHQQEAMPVKKMKNLFFLPEEKLKDRYPSLLKTDLHPSEVKLKNIHMNPSRIKRRNLDLSPTEIQWQSKSLSLAKKNTSLVSRFKIKR", "length": 547, "header": "tr|A0AAA9T2L2-1|A0AAA9T2L2_BOVIN Computationally mapped isoform of C2 calcium dependent domain containing 6 OS=Bos taurus OX=9913 GN=C2CD6 PE=4 SV=1 CANONICAL=E1BEA6-1" }, "locus": { "chromosome": "2", "start_pos": 90168867, "end_pos": 90110576, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111952.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111952.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093034.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093034.1" } ] } }, { "isoform_ac": "A0AAA9TWY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEA6/entry#A0AAA9TWY1-1", "sequence": { "sequence": "MEPPQDMEKVSNAEDNHNRRVHSLYTAPLFQRISQTNLENMQARGSEFSSTAWNVQGRDKPSNLSKVESKEGPGYRLLNMLRKTLKGSENKAPEVTHEAPSLVPFGDVVGCLAIHIRNCKHFTPKIISQHYSNLFIRISINNVVKCTKTCSLLSQNTEKDFMITFDEVKYFSVQVPRRQDDEKNNIRLELMQHDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYGNFGYGFSHQLKPLQKIIKPSMFMDIAPPPERTDPVTNVIIPQPIAYPAFLSPDLNVTVGVPATSQSNQPSVVQLEKLQQQPRERLEKMKKEYRHLSTWAEKASYLEGLLTPGLEHKEPKESNINEIPESQLEERPTDTVTSGVSLIKEEAETIPSELLDNDDKKGLSLPTLNQSSKDDSSVVAPKTDMPSKETDTPLSTIPRLSITEENQIPPLEEHQQEAMPVKKMKNLFFLPEEKLKDRYPSLLKTDLHPSEVVFSPKEYISPCFKPEYTEFKPAYQDCSDRFEELHVTSFKHLENAKSRARLLEKSPDDSHNQFKRFARPYTAPEVNKRGESYTGKFTSPRMVSAGLVHINDSIPEYEIHKMRPKKKIKREY", "length": 619, "header": "tr|A0AAA9TWY1-1|A0AAA9TWY1_BOVIN Computationally mapped isoform of C2 calcium dependent domain containing 6 OS=Bos taurus OX=9913 GN=C2CD6 PE=4 SV=1 CANONICAL=E1BEA6-1" }, "locus": { "chromosome": "2", "start_pos": 90168867, "end_pos": 90045397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097524.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097524.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101101.1" } ] } }, { "isoform_ac": "E1BEA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEA6/entry#E1BEA6-1", "sequence": { "sequence": "MEPPQDMEKVSNAEDNHNRRVHSLYTAPLFQRISQTNLENMQARGSEFSSTAWNVQGRDKPSNLSKVESKEGPGYRLLNMLRKTLKGSENKAPEVTHEAPSLVPFGDVVGCLAIHIRNCKHFTPKIISQHYSNLFIRISINNVVKCTKTCSLLSQNTEKDFMITFDEVKYFSVQVPRRQDDEKNNIRLELMQHDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYGNFGYGFSHQLKPLQKIIKPSMFMDIAPPPERTDPVTNVIIPQPIAYPAFLSPDLNVTVGVPATSQSNQPSVVQLEKLQQQPRERLEKMKKEYRHLSTWAEKASYLEGLLTPGLEHKEPKESNINEIPESQLEERPTDTVTSGVSLIKEEAETIPSELLDNDDKKGLSLPTLNQSSKDDSSVVAPKTDMPSKETDTPLSTIPRLSITEENQIPPLEEHQQEAMPVKKMKNLFFLPEEKLKDRYPSLLKTDLHPSESSPYCCTKENLNRPCSLDELMQDKACGQKNTNRKGKSVVFSPKEYISPCFKPEYTEFKPAYQKFNIKNGFDPFLRNINNKMSVQKRKDQDMLKCRNILSAEIIEHEDQDPPYPTHSKTSRPASKTWPHNLDIISIKALDTKNNLAGDVGITTVKTSHPMNNVAHDPGIITIKTLDTKNNLAHHSSITTIKTLDAKNMLQEKLPHVSLPNFEGDSSVTGKVNVHKCRLSKSLSLTSHIENLKQSMVLKSILSKNLQDLSDRLFSTPGISMDPEARKKSYSSPLLVIHDEQPSSLEDKVFEKSQDLSNWHSEGGILNSKSLLSQIIKNIPPDSLSEGRPGNSPEAEEEPVSEKHLQPGEIDFPTKKKSSFKKKHSKSEISSSKPDLNSLVYDYVIKQIFTAPIFSELAKGVKEASETQIDSQRQLPTAWESSLSSSVLVPHYEESNNEIEFPPANSVISQIIQAFPVDTLLESGIIKVIELDQEYQKGFLLDTETAFAEEKPKDSTEEYSEIRGKAEPLSDQNSAIIHQETTSSFKRVEFIDKGQNTSPHDSKYQSTPDKKSDLPSNNGQRLDREENDTSSTLENLCTSLTGKLNDSDVIMLKSFLKNIFNFFFKYNQSENRPPEKELERLIQHPFQNKTEDLEEIEENFDTADKLDRKPVLNPKLRIFLEELSESEIKNLKSELSKHVQHYLVEKLSESGHITKEDLPKIYQNLYLMNEKVEPKGQNIFLEKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLNEVLQNYFLKNLSDNSLFKETESDPMCSKVSSLRAQSASVSFQELGQDTSSRSFGSRLEINMKYPLSKSLQSYLIALSENEILDLKADLSKHLQSLFIEKLSKSGLITERQLKGISQHINLVNFSSTPLKCIKPDLSLRDENQFVAEHSDKQNKYSKIAQKTTLQKAPEERLVETELTKKEEKEVFSLENIKENPPIIQEQKRHSQEAKILRSIKVKPCSNKNTQVIPLNKSSERLIDTVPKKKKKEHGFMQFPHEENFEFKTESQDQHNWNGKSKITQSKACFEKTLKMKSLDKKDHCNTYKLMVQEKPEALLSPYQRIPNCKMPNGDEEYVNKFTFPSRRNNNLTCLNSEAGEKSKLEDQYCQRLKGNNNNNKKQHLEIFTHYKEEIQTLYTKPNELCNEKYAWVPESQLLKILIAEKNSKPSLFPEVLKRENLKPKVRKERDRVSKQKKSFNKIDSVLPTTPPSTGIHLRKSVPRTLLHWTARRTTHDCSDRFEELHVTSFKHLENAKSRARLLEKSPDDSHNQFKRFARPYTAPEVNKRGESYTGKFTSPRMVSAGLVHINDSIPEYEIHKMRPKKKIKREY", "length": 1847, "header": "tr|E1BEA6-1|E1BEA6_BOVIN Isoform 1 of C2 calcium dependent domain containing 6 OS=Bos taurus OX=9913 GN=C2CD6 PE=4 SV=2 CANONICAL=E1BEA6-1" }, "locus": { "chromosome": "2", "start_pos": 90168867, "end_pos": 90045397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055126.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055126.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048394.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048394.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616081", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616081", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5F8MPU3-1", "protein_name": "Cation channel sperm-associated targeting subunit tau", "gene_name": "Catspert", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELPPPGNRRVSINNPQETSGRVPTTSAGFPTQSSKISLKRSTYAYRPSMMSNRSSGGQSLLPSSILQKTSLNPPGSLQSKPSNLSSVHYADEEGKPLTDKNKDKDKGRGKGKGTGTRLLTMLRKTLQGSQSDEMAIANQTPNLIPFGDVVGCLAIHIKSCRQFSQRFLGQQRFNLFMRVSINNIVKCTKIRHLKAVNNEKNLVLRFGEMKYFSVQVPRRQDDERNFIYLELMHDGGDPESPPIPLGGAESHLYEVIQKGCFTEVMHLMHKNSSICRVEVEFMFSYGNFGYGFSHQLKPLQKAIEPSMFMNIAPPPERTDPVTNVITPQRVEYPAFLSPEFNVSIGVPEASHATVVQLEKLREKPRERLERMKEEYKNMSTWIEKADYLRNLINPKMTKRDNKGSSIPSESNSSALEELERTTYDIHHRKYEAISNEYGDKEGRVIPVLKVLDQNYSEVFLPKSSDSTPLEDVLLPPIHSLQIVEENEMPHLPKTSEPEDRPHEERKSIVFSSDEELMPKHPSILKISSSQQENRRKMEKSPHFSDVLIIPDKPFEDLNTNKKGRPPIELRKSWERHPTDVACSLRKVAFAQKDYTIPVCKAETTEFKPKHQFQKLSKSGLDPFLRNINSKMSFRKKKDHDDGYRNLSTSSAEILEHEDQDPPYPGHSGSAGSDATWAENPSPVTVQMVNRDSLPPDLITATIVISDRKNKLSLDSVFNSANSLNTKSIFASDNPVVSLTKLSDSDNKLITDSSFNTTKPSNRRLSKDSNFNTTKPSDRKLSSDPSSNTTKPSDTKLFSDPSSNKLSQGPSSNASQLSGSNRLSHNPSINGNKSSYTSDLNKVSRDPSIVSTISSDPNKLSRDPSFVLAKSSDPNKLSHYPSIISAKSSDPNKLSHDPSFVSARSSDPNKLSHDPSIISARSSDPIKLSRDPSFVSARSSDPNKLSHDPSIISARSSDPNKLSRDPSINSTKLSDPSKLSRDPSIFSTKSSDPNKLYRVPSIISGMSSNPKLSRDPSIISGMSSDPKLSRDPSIISAKSSDPNKLSHDPSIISGMSSNPNKLSHDPSIISMKLSDMSKLSRESSINASKSSDTNQLSYDPNIISAKSLDSNNSSASSSPTVNSDTTTNAAEPSGTKNMLDPVVSTIDSSDKQSKLEWLPNVQGASSVTENINTHRSSNSVNFTSDIDILKQSIVLKSILSKNLQDLSDELFSKSELYTNDEGYSPPPSVHSRPSDSTDDRVLGKVQDLNSWRSSKDLLNSQVLLSPVVKNSPQDLLPEGEPGKSSDIEDYVSEKLLEAAGRNFPMNRKSSFKKKHLVSEESSSEHVLSGSIYEYVIKQIFTAPIFSQLGIGIKSSSEARMDSQNQLLTPWERSVTSHIINYEEKDSDVNLSQSKSIISQIIQSFPVNTLLESGVIKVIELDKEHQNSLLDSQTTSSTEQYSDSRSQIKLLSRQNTSSINPLDSSVSGAEYTEDCQSISTQESKYPVRDTKSDSPNDTEEMELDSNLESSSSSLDKVKDTDTAKLKNILKNIFSIFFKYNQSERRQQPEKDSESLIKHSSSSGSEHLEKTQENFNKADKKVDRKPILNPKLRMFLEKLSETEVKNLKSELSKHIQHYLVERLTESGHITKEDLPTIYHKLYLMNEKVELKEQTPFQEKYSETVKEIMSFVNNFNHHFIDKHLETKLRGFLSEILQNYFLKNLSVSNLFNETDAMALHASMSPVRSKSELGQDIADGNFGSSLKINMQYPVTKSLQHYLQDLSENELLSLKTDLSKYLQVLFIEKLYKSGLVSERQLKGISQEIISLHSPSIPLKHIKTNLPFRNESYFMREDSEEQMKYLKNGQNAALHVLLKDKCGETELSRKKERESSFSQILKENLPAIWEQKNIYTREEETLNLIQMQSFLNKNNQANPLTRSPERPSDISLKKQKKDHGFMQFTQVEGSVYKTEIQDPYSWDSRSKTIQSKPCLEKTLKMKLLDKRENNNFYKLTAQEKLDTEFSSYLKLPNCKIPKEKEPISRLSFPTWKTNTFIHVKPEIGEQSKLDHYYQRLKGNNNNNKKHLVTFAQFKNEMETLYRNPYEACNEKRAKISESQSFKYKEKEKSSRPFFFPEVLKRENTKSKRKERDHATKPKKSFHKIVRLLPATLPTTRPHLRKSAPRNLLHWTARRTIHDCLDRFDDLHAPTVKCPKKSKSGARLLGKSPEDSHNQAKHCARPYTAPEPNKRRESAAWKFASPRMVSAGLLHLYVTPAYGIRKVRSKRKLKEDIEKRPLISEIIQMLDNAE", "length": 2282 }, "evidence": [ { "id": "E1BEA6", "url": "https://omabrowser.org/oma/group/E1BEA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8I6G3E6-1", "protein_name": "C2 calcium dependent domain containing 6", "gene_name": "Catspert", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELPPPGHRRVSISNPQETSGRVPTTPAAFPSHPSNISSVSSKRSVQSSVYRPSIMSNRSLGTQSLLPNPIIQKSSLNPPGFLQSKTSNVSSVRYADEEGKPLTEKDKDKEKGKGTGTRLLNMLRKTLQGSQSDEMVVANQTQNLIPFGDVVGCLAIHIKSCRQFTQRFIAQQHFNLFMRISVNHIVKCTKIRHLKAVNNEKNLVLKFDEVKYFSVQVPRRQDDERNYIYLELMQDAGDSEKLPYPLGNAESHLYEVIQKGCFTEVMQMMRRNTPICRVEVEFMFSYGNFGYGFSHQLKPLQKVIEPSMFMKITPPPERTDPVTNIITPQRVEYPAFLSPEFNVNIGGPETSQATVVQLEKLREKPRERLERMKEEYKSMNTWIEKADYLRNLINPKLLKKDSKGSVEPSGSNSSVLEELERTTHDIHYRKSEAISNELVDYSDKEGRVIPVLKLLDQNYSEFSLPKSGDSTPPEDVTLPPIHTLQIIEEDEMPRVPNTSELEDRPHEDRKSVIFSSDEELMPKHPSILKINPSLQENRRKMEKSPHFSDVLIIPDKPEELNTNKKGRPSIELRKSWERHPTDIVCSLRKVAFAQKEYAIPVCKAETTEFKPKHQFQKLSRSGLDPFLRNLNSKMPFRKKKDHEDGYRHPSTLSTEILEHEDQDPPYPEHPGSAGSDPIRTENPRPFTVQMGNKKNSLPPDPITATVISDRRNRLLFDSTFNSENNSNTKSIFASDNPVVSLTKLSDSDNKLLTDSSFNTMKPSNRRLSRDSSSNIIKPSDGKLGSECSSNTTKLSDKRLSSAPSSGTTKPSDTKLLSDPSNSKLSRDPSSNGTQLSGSNRLSHNPSINGNKYSHTSDLNKVSRDPSFISTKSSDLNKLSHDPSIISTRSSDPNKLSHDPSFISTKSSDPNKLSRDPSIISTKLSDPNKLSRDPSIISTKLSDPNKLSHDPSFISTKSSEPNKLSRDPSIISTKLPDASKLSHDPSIVSTKSSDPNKFSYDPSFISKMSSDANKFSRNPSIISTRYSDPSKLSSDPSIISTRFSDSSKLSSDPSIISTRFSDPSKLSSDPSIISARFLDPSKLSSDSSIISARVSDPSKLSYDSSIISTRSSDPNKLSHDSSIIPTKLSDPNKLSRDPSFISTKLSDPNKLSRDPSIISTKLSDPNKLSRDPSIISTKLSDPNKLSRDPSFISTKLSDPNKLSRDPSIISKKSSDPNKLSRDPSIISSKSSDSNKLSRDPSFISTKSSDPSKLSHDPSFISIKSSDPNKFSRDPSIIPAKLSDANKLSRDPSIISTRSSDPNKLSHDSSIISTKLSDPNKLSRDPSFISTKSSDSNKFSRDPSIISTKLSDANKLSRDPSIISTKLSDPNKLSHDPSNIPTKLSDPNKLSRDPSIISTKLSDPNKLSHDPSIISTKSSDPSKLSRDPSINARKSSDTSKLSHDPSVISTKALDGNSRLPSGSPVNSDTTTNIAKPPVTKDPAISTVDSSDKQGKLEECLQNVSLSNVQRASSVTENVNMHRPSSSINFTSDIENLKQSIVLKSILSKNLQDLSDELFSKAEVCTTESCSPSPNVHNRPSDTTDDRVFEKVQDINSWRSSKDLLNSQVLLSPVVKNSPQNLLPEGEPGKSSDIEDYVSEKVLEAAERNFPMNRKSTFKKKHLISEESGSERLLNSSIYEYIIKQIFTAPIFSQLGIGTKSSREAQMDSQDQLLTPWESLRRINYEEKGNEVHLSQSKSVISQIIQSFPVNTLLESGIIKVIELNKEHQNSLLDSQTTSSTEQYSEMKSQIKLISRQNTSSIDPSDSSVSGAEYTEDCQSISTQASKCLMPDAKADSPTDTEETELDSNVESSSSSLDKVKDTDTAMLKSLLKNIFSIFFKYNQSEKRQQPEKESESLIKHSSSSVTEHLEKTQENFNKVDKKVDRKPILNPKLRVFLEKLSETEVKNLKTELSKHIQRYLVERLTESGHITKEDLPTIYHKLYLINEKAELKEQIPFQEKYSDTVKEIMSFVNNFNHHFIDKHLEAKLRAFLSEILQNYFLKNLSVSNLFNETDAMALHASMSPARSKSELGQDIADGNFGPSLKINMKYPVSKSLQNYLQDLSESELLSLKADLSKYLQVLFLEKLYKSGLMTERQLKGISQEIISLHSPPIPLKHLKTNLAFRNESYFMREDSEEQKKYSKNGQNTALQALLKGKCGETELSRKEEKESSFSQNLKENLPTIWEQKTIYCKEEERLNLIEIRSSLNKNNQANSLTRSPERPSDTSLKKQKKDHGFMQFTQVESSAYKTEIQDPYSWDGRSKTIQSKPCFEKTGQMKQVDKRENNNVYKSTAQEKLDTEFSSYLKLPNCKVSKENESTSRLSFPTWQTNAFIHVKPEIGEQSKLDHYYQRLKGNNNNNKKHLVTFAQFKDEMETLYKNPYEACNEKRAKISESQSFKYKEHEKNSRPFFFPEVLKRENTKSKRKEKDHATKPKKSFHKIVRLLPVTLPTTRPHLRKSVPRNLLHWTARRTIHDCLDRFDDLHAPPSVKCTKKSRSRARLLGKSPDDSHNQAKHCARPYTAPEPNKRRESATWKFASPRMVSAGLVHLYATPEYEIRKMRSKRKLKEDIEKRPLISEIIQMLDTAE", "length": 2625 }, "evidence": [ { "id": "E1BEA6", "url": "https://omabrowser.org/oma/group/E1BEA6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "E1BEA6", "url": "https://www.uniprot.org/uniprotkb/E1BEA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1042, "end_pos": 1044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1073, "end_pos": 1075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1091, "end_pos": 1093, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1113, "end_pos": 1115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1134, "end_pos": 1136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1272, "end_pos": 1274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1384, "end_pos": 1386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1491, "end_pos": 1493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1606, "end_pos": 1608, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1826, "end_pos": 1828, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEA6" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 223, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1042, "end_pos": 1044 }, { "start_pos": 1073, "end_pos": 1075 }, { "start_pos": 1091, "end_pos": 1093 }, { "start_pos": 1113, "end_pos": 1115 }, { "start_pos": 1134, "end_pos": 1136 }, { "start_pos": 1272, "end_pos": 1274 }, { "start_pos": 1384, "end_pos": 1386 }, { "start_pos": 1491, "end_pos": 1493 }, { "start_pos": 1606, "end_pos": 1608 }, { "start_pos": 1826, "end_pos": 1828 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEB4-1", "uniprot_ac": "E1BEB4", "uniprot_id": "E1BEB4_BOVIN", "mass": { "chemical_mass": 129421.0, "monoisotopic_mass": 129421.0 }, "refseq": { "ac": "XP_002697177", "name": "fibulin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697177" }, "gene_names": [ { "name": "FBLN2", "type": "recommended", "evidence": [ { "id": "E1BEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ] }, { "name": "FBLN2", "type": "synonym", "evidence": [ { "id": "XP_002697177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697177" } ] } ], "protein_names": [ { "name": "Fibulin-2", "type": "recommended", "evidence": [ { "id": "E1BEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEB4/entry#names_and_taxonomy" } ] }, { "name": "fibulin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697177" } ] } ], "function": [ { "annotation": "Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LJK4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK4#function" }, { "database": "UniProtKB", "id": "ARBA00053524", "url": "https://www.uniprot.org/uniprotkb/ARBA00053524#function" }, { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBLN2", "url": "https://www.uniprot.org/uniprotkb/E1BEB4", "locus": { "chromosome": "22", "start_pos": 58328989, "end_pos": 58398387, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004014", "url": "https://www.ensembl.org/id/ENSBTAG00000004014" } ] } } ], "crossref": [ { "id": "E1BEB4", "url": "https://alphafold.ebi.ac.uk/entry/E1BEB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00017", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00017", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511854", "url": "https://www.ncbi.nlm.nih.gov/gene/511854", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511854", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511854", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNTCRDI", "url": "https://omabrowser.org/oma/group/MNTCRDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJK4", "url": "https://www.orthodb.org/?gene=A0A3Q1LJK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BEB4", "url": "https://www.orthodb.org/?gene=E1BEB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01821", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01821", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697177", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJK4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJK4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQY7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARLGEPMGAWLALALALALSPGGAAAPGQDCTGVECPPLENCIEDALEPGACCATCVQRGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMPCPELPPNCIEAVVAADSCPQCGQVGCVHSGRKYAAGHTVRLAPCRACHCPDAGGELICYPLPDCHGDAAPGNTSDAEDGDPERHYEDPYSYDQEVAEAEALAGELQAGAGGPAALGGGGQPPSALQATLWPAALPRPTAAAALGPPAPVQAKARRVTDDGQEDREVPAVQEQLAAGGPRGLDGRPTAGPMPAHPVREEGAEARAGVEENLIPDVQATHRSAGPPPTFSMPNILLTETTQGPPEAPTEPSAHAALTTLQQETARAPPTQEVPQQPAGPRSRLEEEEDPNSVHSVPRAGLEVSTKDLIETCCAAGQQWAIDSDECLDIPESGAEGDACRTAQKQCCVSYLKEKSCMAGVLGAKEGEACGDEDSDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEDPLIVPEVRRPPEPEAVPRRVSEAELASREALSLGTETELPNSLPGDDQDECLLLPGELCQHLCINTVGSYRCACFPGFSLQDDGRTCRPEGAPPKPEAAEESAQRPESAQVAPNTIALPVPQPNTCQDNGPCKQVCRVVGDTAMCSCFPGYAIMADGVSCEDQDECLLGTHDCNRRQFCVNTLGSFYCVNHTVLCAEGFILNMHRKCVDINECVTDLHTCSRREHCVNTVGSFHCYKALTCEPGYRLEDGECTDVDECELGTHNCQAGAVCHNTKGSFYCQARQRCLEGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPVICGRGYHASQDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKPGFQRDAFGRTCIDVNECWTSPTRLCQHTCENTLGSYRCSCASGFLLAADGKHCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGASILCTFRCINVPGSYQCTCPERGYTMTANGRSCKDLDECALGTHNCSEAETCHNIQGGFRCLRFDCPPNYVRVSETKCERALCHDFLECQNAPARITHYRLNFQTGLLVPAHIFRISPVPAFAGDTIALTITKGNEEGYFGTRRLNAYTGVVFLQRTVREPRDFALDVEMKLWRQGSVTTFLAKMHIFFTAFAL", "length": 1207, "header": "tr|E1BEB4-1|E1BEB4_BOVIN Isoform 1 of Fibulin-2 OS=Bos taurus OX=9913 GN=FBLN2 PE=3 SV=3 CANONICAL=E1BEB4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEB4/entry#A0A3Q1LJK4-1", "sequence": { "sequence": "MARLGEPMGAWLALALALALSPGGAAAPGQDCTGVECPPLENCIEDALEPGACCATCVQRGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMPCPELPPNCIEAVVAADSCPQCGQVGCVHSGRKYAAGHTVRLAPCRACHCPDAGGELICYPLPDCHGDAAPGNTSDAEDGDPERHYEDPYSYDQEVAEAEALAGELQAGAGGPAALGGGGQPPSALQATLWPAALPRPTAAAALGPPAPVQAKARRVTDDGQEDREVPAVQEQLAAGGPRGLDGRPTAGPMPAHPVREEGAEARAGVEENLIPDVQATHRSAGPPPTFSMPNILLTETTQGPPEAPTEPSAHAALTTLQQETARAPPTQEVPQQPAGPRSRLEEEEDPNSVHSVPRAGLEVSTKDLIETCCAAGQQWAIDSDECLDIPESGAEGDACRTAQKQCCVSYLKEKSCMAGVLGAKEGEACGDEDSDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEDPLIVPEVRRPPEPEAVPRRVSEAELASREALSLGTETELPNSLPGDDQDECLLLPGELCQHLCINTVGSYRCACFPGFSLQDDGRTCRPEGAPPKPEAAEESAQRPESAQVAPNTIALPVPQPNTCQDNGPCKQVCRVVGDTAMCSCFPGYAIMADGVSCEDINECVTDLHTCSRREHCVNTVGSFHCYKALTCEPGYRLEDGECTDVDECELGTHNCQAGAVCHNTKGSFYCQARQRCLEGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPVICGRGYHASQDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKPGFQRDAFGRTCIDVNECWTSPTRLCQHTCENTLGSYRCSCASGFLLAADGKHCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGASILCTFRCINVPGSYQCTCPERGYTMTANGRSCKDLDECALGTHNCSEAETCHNIQGGFRCLRFDCPPNYVRVSETKCERALCHDFLECQNAPARITHYRLNFQTGLLVPAHIFRISPVPAFAGDTIALTITKGNEEGYFGTRRLNAYTGVVFLQRTVREPRDFALDVEMKLWRQGSVTTFLAKMHIFFTAFAL", "length": 1160, "header": "tr|A0A3Q1LJK4-1|A0A3Q1LJK4_BOVIN Computationally mapped isoform of Fibulin-2 OS=Bos taurus OX=9913 GN=FBLN2 PE=3 SV=1 CANONICAL=E1BEB4-1" }, "locus": { "chromosome": "22", "start_pos": 58377471, "end_pos": 58329484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082158.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082158.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059623.1" } ] } }, { "isoform_ac": "A0A3Q1MQY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEB4/entry#A0A3Q1MQY7-1", "sequence": { "sequence": "MARLGEPMGAWLALALALALSPGGAAAPGQDCTGVECPPLENCIEDALEPGACCATCVQRGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMPCPELPPNCIEAVVAADSCPQCGQVGCVHSGRKYAAGHTVRLAPCRACHCPDAGGELICYPLPDCHGDAAPGNTSDAEDGDPERHYEDPYSYDQEVAEAEALAGELQAGAGGPAALGGGGQPPSALQATLWPAALPRPTAAAALGPPAPVQAKARRVTDDGQEDREVPAVQEQLAAGGPRGLDGRPTAGPMPAHPVREEGAEARAGVEENLIPDVQATHRSAGPPPTFSMPNILLTETTQGPPEAPTEPSAHAALTTLQQETARAPPTQEVPQQPAGPRSRLEEEEDPNSVHSVPRAGLEVSTKDLIETCCAAGQQWAIDSDECLDIPESGAEGDACRTAQKQCCVSYLKEKSCMAGVLGAKEGEACGDEDSDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEDPLIVPEVRRPPEPEAVPRRVSEAELASREALSLGTETELPNSLPGDDQDECLLLPGELCQHLCINTVGSYRCACFPGFSLQDDGRTCRPEGAPPKPEAAEESAQRPESAQVAPNTIALPVPQPNTCQDNGPCKQVCRVVGDTAMCSCFPGYAIMADGVSCEDINECVTDLHTCSRREHCVNTVGSFHCYKALTCEPGYRLEDGECTDVDECELGTHNCQAGAVCHNTKGSFYCQARQRCLEGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPVICGRGYHASQDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKPGFQRDAFGRTCIDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGASILCTFRCINVPGSYQCTCPERGYTMTANGRSCKDLDECALGTHNCSEAETCHNIQGGFRCLRFDCPPNYVRVSETKCERALCHDFLECQNAPARITHYRLNFQTGLLVPAHIFRISPVPAFAGDTIALTITKGNEEGYFGTRRLNAYTGVVFLQRTVREPRDFALDVEMKLWRQGSVTTFLAKMHIFFTAFAL", "length": 1118, "header": "tr|A0A3Q1MQY7-1|A0A3Q1MQY7_BOVIN Computationally mapped isoform of Fibulin-2 OS=Bos taurus OX=9913 GN=FBLN2 PE=3 SV=1 CANONICAL=E1BEB4-1" }, "locus": { "chromosome": "22", "start_pos": 58377471, "end_pos": 58329484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085738.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085738.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074067.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074067.2" } ] } }, { "isoform_ac": "E1BEB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEB4/entry#E1BEB4-1", "sequence": { "sequence": "MARLGEPMGAWLALALALALSPGGAAAPGQDCTGVECPPLENCIEDALEPGACCATCVQRGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMPCPELPPNCIEAVVAADSCPQCGQVGCVHSGRKYAAGHTVRLAPCRACHCPDAGGELICYPLPDCHGDAAPGNTSDAEDGDPERHYEDPYSYDQEVAEAEALAGELQAGAGGPAALGGGGQPPSALQATLWPAALPRPTAAAALGPPAPVQAKARRVTDDGQEDREVPAVQEQLAAGGPRGLDGRPTAGPMPAHPVREEGAEARAGVEENLIPDVQATHRSAGPPPTFSMPNILLTETTQGPPEAPTEPSAHAALTTLQQETARAPPTQEVPQQPAGPRSRLEEEEDPNSVHSVPRAGLEVSTKDLIETCCAAGQQWAIDSDECLDIPESGAEGDACRTAQKQCCVSYLKEKSCMAGVLGAKEGEACGDEDSDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEDPLIVPEVRRPPEPEAVPRRVSEAELASREALSLGTETELPNSLPGDDQDECLLLPGELCQHLCINTVGSYRCACFPGFSLQDDGRTCRPEGAPPKPEAAEESAQRPESAQVAPNTIALPVPQPNTCQDNGPCKQVCRVVGDTAMCSCFPGYAIMADGVSCEDQDECLLGTHDCNRRQFCVNTLGSFYCVNHTVLCAEGFILNMHRKCVDINECVTDLHTCSRREHCVNTVGSFHCYKALTCEPGYRLEDGECTDVDECELGTHNCQAGAVCHNTKGSFYCQARQRCLEGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPVICGRGYHASQDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKPGFQRDAFGRTCIDVNECWTSPTRLCQHTCENTLGSYRCSCASGFLLAADGKHCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGASILCTFRCINVPGSYQCTCPERGYTMTANGRSCKDLDECALGTHNCSEAETCHNIQGGFRCLRFDCPPNYVRVSETKCERALCHDFLECQNAPARITHYRLNFQTGLLVPAHIFRISPVPAFAGDTIALTITKGNEEGYFGTRRLNAYTGVVFLQRTVREPRDFALDVEMKLWRQGSVTTFLAKMHIFFTAFAL", "length": 1207, "header": "tr|E1BEB4-1|E1BEB4_BOVIN Isoform 1 of Fibulin-2 OS=Bos taurus OX=9913 GN=FBLN2 PE=3 SV=3 CANONICAL=E1BEB4-1" }, "locus": { "chromosome": "22", "start_pos": 58377471, "end_pos": 58329484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005240.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005240.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005240.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005240.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 358, "start_aa": "Thr", "end_pos": 358, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511854", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511854", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A720-1", "protein_name": "Fibulin-2", "gene_name": "Fbln2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TMLLQESAGVWLALALVTALTLSPSMGVPWQDCTGAECPPLENCIEEALEPGACCATCVQQGCACEGYQYYDCVQGGFVDGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHSGRKYAAGHTVHLSSCRACHCPDAGGELICYQLPGCHGNFSDAEEGDSERQYEDPYSYDQEVAEAEATVAIVNEVQAGAEGPPAALGGGNLPPSSIRVTPWPVALPRPTAAAALGPPAPVQAKARRVTLDIDEEEEEEVEEILATEPPVAGSPGRLDSLPTTSPARPGLPVQEKEAEAKAGPEENLIPEAQATSRSVTQEGAAPLPKSGLAGLSPSLATDSSSEDALKSSSQPTLSTLPPDRAQVSPSPETPEEIPQRPQLLPRSRAEEDTDPNSVHSVPRGDPDGSTKDLVETCCAAGQQWAIDNDECQEIPENGAQSDVCRIAQRHCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCSHVMLSCCEGEEPLIVPEVRRPPEPGATPRRVSETEMGSREALSLGTEAELPNSLPGDDQDECLMLPGELCQHLCINTVGSYRCACFPGFELQGDGRTCRPDGGAPQLDTARESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQVCRVIGDTAMCSCFPGYAIMADGVSCEDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLTDGECTDVDECVTGTHNCQAGFSCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLLEPCRSGFSCINTVGSYTCQRNPLVCRRGYHANEEGSECVDVNECETGVHRCGEGQLCYNLPGSYRCDCKPGFQRDAFGRTCIDVNECWISPGRLCQHTCENTPGSYRCSCAAGFLLAADGKHCEDVNECETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTTCQDISECQTSPARITHYQLNFQTGLLVPAHIFRIGPAPAFAGDTISLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDFALDVEMKLWRQGSVTTFLAKMYIFFTTVAP", "length": 1175 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1A9U7-1", "protein_name": "Fibulin-2", "gene_name": "FBLN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDRHQSWQRSCLNAAFFMLLWSGVSHAQRDCTGVECQPLDNCIEDVLEPGECCATCLQHGCTCEGYQYYDCVNVGFVNGKVPEGQSYFVDFGSTECSCPKGGGKISCQFMLCPELPPNCIDAVVPADGCPQCGRIGCLHEGQKYVAGHTFHMPPCKVCHCPNAGGELMCYQLPNCNTFALNTVSPMDAEDNEPERHYDDPYSYDQEAPEGDNAQVESPKKYRSYSSHLEQESISQEQSEDYDYLPVSIAPSSSAVAGMYAEETTTPLTTPAPKLLSEFRSATERTEWKRVPSTTAPPPQQTTHKEAPVTTSAPLEHTTATTETPKQLGKPDRRPKGKQGDKERSEQERTPHSKMKKHTRKEDPGNSIHLDLKEVNLTEPSSAKSSQETHEGNAFPKVKFSATTSPPVALKEDRSQSSQKQSQTLYRYHPEEDGDPNSIHANPRLPEGSTKELIESCCGAGQQWAIDNGECTETPISGVDGDICRIAQKQCCISTVKENSCLAGMIAAKEGDACGPEESDTCGGSSYKQCCDCCNLGLRLRSEGKTCESNINLGYPCSHVMLSCCEGGDHFIHPEIKKHPEPSPTATPEKISETEDHNEALSISNEAELSNNLPGDDLDECLLYGGELCQHLCINTVGSYKCSCFPEFTLQEDGTSCSPDPDRGQVTRLEVEATIPPAASPQPLLIVSLQEEQDKCKDNGPCKHICSVMEGNVVCSCLSGYTIMADGISCEDINECVTDAHTCQRREHCVNTMGSFKCLQELSCQPGYELKDGECVDIDECERGTHSCKVNFVCQNTEGSFYCESKQRCMDGFLQDPEGNCVDINECTSLPEPCKPGFNCINTVGSYTCQRNMLTCSRGYHSNEDGTRCVDVDECQTGVHRCGEGQICHNLPGAYRCDCKMGYQYDAFSRSCIDINECWNYPGRLCQHTCENTPGSYHCTCSSGFHLSYDGKHCEDVNECDTSPCSQECANVYGSYQCYCRQGFQLAEDGHSCKDIDECTQSAGILCTFRCVNVPGSYQCACPEQGYTMAANGRTCRDIDECAIGTHNCSAAESCYNIQGSFRCLSFECPSNYRKVSDMRCERISCFNYLDCQNTPVRITYYQLNFQTNIMVPAHIFRIGPSPAYAGDNIILTINKGNEENYFSTRRLNSYTGIVYLQRQVKEPKDFLLDVEMKLWRQGTYTTFLAKIYIFITAHTY", "length": 1196 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SPG5-1", "protein_name": "Fibulin-2", "gene_name": "FBLN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLLREPGGTWLALALALALGTGSGMAAPGQDCTGIECPPLENCIEEALEPGECCATCVQRGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCIHSGRKYAAGHTVHLSPCRACHCPDAGGELICYQLPDCDGDAEAELATATGNFSDAEEGDPERHYEDPYSYDQEVAEAEAAEALAGELQAGTGGPAALGGGRQPPSSIQATPWPVALPRPTAATALGPPAPVQAKARRVTEDRQEREELTHREQPAAGGPRGLGGLPTAGPVGPDLPVQEEGAEARAWPEENLIPDAQATPGSTGQEGAGPVPASSTPSVLSSQAASSPEVPTEPSTHTSLTIPRQEAAQAPPTQEVPKQPPVLPRSQPEDPDPNSVHSVPRGDPEVSTKDLIETCCAAGQQWAIDNDECLDIPESGAEGDVCRTAQKHCCVSYLKEKSCVAGVMGAKEGEACGDEDNDTCSVSLYKQCCDCCGLGLRVRAEGQACESNPNLGYPCNHVMLSCCEGEDPLIVPEVRRPPEPEAAPQRVSEAELASREALSLGTETELPNSLPGDDQDECLLLPGELCQHLCINTVGSYRCACFPGFSLQDDRRTCRPDGGRPQPETTEESALRPESSQVAPNTIALPVPQPNTCKDNGPCKQVCTVIRDTVMCSCFPGYAIMADGVSCEDQDECLLGAHDCSRRQFCVNTLGSFYCVNHTVLCAEGFLLNPHRKCVDINECVTDMHTCSRSEHCVNTVGSFRCYKALTCEPGYMLKDGECTDVDECELGTHSCQVGFTCQNTKGSFYCQPRQRCMDGFLQDPEGNCVDINECTSLSEPCQPGFSCVNTVGSYTCQRNPLICGRGYHASQDGTKCVDVNECETGVHHCSETQVCHNLPGSYRCDCKAGFQRDAFGRTCIDVNECWASPSRLCQHTCENTLGSYRCSCASGFVLAADGKHCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCIDIDECAQGAGVLCTFRCINVPGSYQCACPERGYTMTANGRSCKDLDECALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTLCQDFVECQNAPARITHYRLNFQTGLLVPAHIFRISPVPAFAGDTIALTITKGNEEGYFGTRRLNAYTGVVFLQRSVREPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL", "length": 1221 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P37889-1", "protein_name": "Fibulin-2", "gene_name": "Fbln2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLQESAGVWLALALVTALTPSPSMAVPWQDCTGAECPLLENCIEEALEPGACCATCVQQGCACEGYQYYDCVQGGFVDGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHSGRKYAAGHTVHLSSCRACHCPDAGGELICYQLPGCHGNFSDAEEGDSERQYEDPYSYDQEVAEAEATTAIVNEVQAGAEGPPAALGGGNLPPSSIRVTPWPVALPRPTAAAALGPPAPVQAKARRVTLDTEEDEEEEEEETLVTEPPTAGSPGRLDSLPTRSPARPGFPVQEKEAEAKAGPEENLIPDAQVTPRSVMQEGAAPLPRSGLAALSPSLATDSSSEDPVKPSDHPTLSTLPPDRAQVSPSPETPEEIPQHPQLLPRFRAEEDIDPNSVHSVPRGDLDGSTKDLIETCCAAGQQWAIDNDECQEIPENGAQSDICRIAQRQCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPEAAPRRVSEMEMASREALSLGTEAELPNSLPGDDQDECLMLPGELCQHLCINTVGSYRCACFPGFELQGDGRTCRPDRGAPQLDTARESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQVCRVVGDTAMCSCFPGYAIMADGVSCEDQDECLMGTHDCSWKQFCVNTLGSFYCVNHTVLCAEGYILNAHRKCVDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLTDGECTDVDECVTGTHNCQAGFSCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLLEPCRSGFSCINTVGSYTCQRNPLVCGRGYHANEEGSECVDVNECETGVHRCGEGQLCYNLPGSYRCDCKPGFQRDAFGRTCIDVNECWVSPGRLCQHTCENTPGSYRCSCAAGFLLAADGKHCEDVNECETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTTCQDITECQTSPARITHYQLNFQTGLLVPAHIFRIGPAPAFAGDTISLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDFALDVEMKLWRQGSVTTFLAKMYIFFTTFAP", "length": 1221 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P98095-1", "protein_name": "Fibulin-2", "gene_name": "FBLN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLLWEPAGAWLALGLALALGPSVAAAAPRQDCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELICYQLPGCHGNFSDAEEGDPERHYEDPYSYDQEVAEVEAATALGGEVQAGAVQAGAGGPPAALGGGSQPLSTIQAPPWPAVLPRPTAAAALGPPAPVQAKARRVTEDSEEEEEEEEEREEMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPEENLILDAQATSRSTGPEGVTHAPSLGKAALVPTQAVPGSPRDPVKPSPHNILSTSLPDAAWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL", "length": 1184 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V4B8-1", "protein_name": "EGF-like domain-containing protein", "gene_name": "CT7856", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFYKLCAFMCFLIVGGHVTTTMASDSISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQDCELGRLAALDGTRCDGEGNVTSSSYATCCRSCQIGLAVKASKANCKDPLFSFIFLIESYRACCYGSADFKDQPGIDEIDKANSITDEGELPFVSEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVNVILKKSLEGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQHTF", "length": 917 }, "evidence": [ { "id": "E1BEB4", "url": "https://omabrowser.org/oma/group/E1BEB4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "pmid": "" }, { "name": "extracellular matrix binding", "id": "GO:0050840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050840", "evidence": [ { "database": "UniProtKB", "id": "E1BEB4", "url": "https://www.uniprot.org/uniprotkb/E1BEB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1058, "end_pos": 1060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEB4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1207, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEB4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEB4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 358 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1058, "end_pos": 1060 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 723, "end_pos": 725 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEC1-1", "uniprot_ac": "E1BEC1", "uniprot_id": "E1BEC1_BOVIN", "mass": { "chemical_mass": 163694.0, "monoisotopic_mass": 163694.0 }, "refseq": { "ac": "NP_001193027", "name": "WD repeat-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193027" }, "gene_names": [ { "name": "WDR7", "type": "recommended", "evidence": [ { "id": "E1BEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEC1" } ] }, { "name": "WDR7", "type": "synonym", "evidence": [ { "id": "NP_001193027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193027" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 7", "type": "recommended", "evidence": [ { "id": "E1BEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#names_and_taxonomy" } ] }, { "name": "TGF-beta resistance-associated protein TRAG", "type": "synonym", "evidence": [ { "id": "E1BEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001193027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193027" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEC1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR7", "url": "https://www.uniprot.org/uniprotkb/E1BEC1", "locus": { "chromosome": "24", "start_pos": 56368141, "end_pos": 56001571, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004005", "url": "https://www.ensembl.org/id/ENSBTAG00000004005" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004005", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004005", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536469", "url": "https://www.ncbi.nlm.nih.gov/gene/536469", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536469", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536469", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS69", "url": "https://www.orthodb.org/?gene=A0A3Q1LS69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M7G6", "url": "https://www.orthodb.org/?gene=A0A3Q1M7G6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BEC1", "url": "https://www.orthodb.org/?gene=E1BEC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44099:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44099:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23123", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23123", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS69", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS69-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7G6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7G6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NMY4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NMY4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEC1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGNGGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQVAAPVVSARSEADQSGSDPASTPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQLRCVKTYRVPPVQPASPGSHNALRLARLIWTSNRNVILMAHDGKEHRFMV", "length": 1490, "header": "tr|E1BEC1-1|E1BEC1_BOVIN Isoform 1 of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=4 CANONICAL=E1BEC1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS69-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0A3Q1LS69-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQALIFRDFCEIQNSITKGSRYKEG", "length": 1410, "header": "tr|A0A3Q1LS69-1|A0A3Q1LS69_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=2 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56368140, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072896.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072896.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057904.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057904.2" } ] } }, { "isoform_ac": "A0A3Q1M7G6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0A3Q1M7G6-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQSFPETECV", "length": 1395, "header": "tr|A0A3Q1M7G6-1|A0A3Q1M7G6_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=2 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56350842, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070595.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070595.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065999.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065999.2" } ] } }, { "isoform_ac": "A0AAA9RV77-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0AAA9RV77-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQNPRKC", "length": 1357, "header": "tr|A0AAA9RV77-1|A0AAA9RV77_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56333338, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076162.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076162.1" } ] } }, { "isoform_ac": "A0AAA9SLX2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0AAA9SLX2-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQLPER", "length": 1391, "header": "tr|A0AAA9SLX2-1|A0AAA9SLX2_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56354601, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116088.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116088.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086275.1" } ] } }, { "isoform_ac": "A0AAA9SP11-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0AAA9SP11-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQHQNNFR", "length": 1393, "header": "tr|A0AAA9SP11-1|A0AAA9SP11_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56351378, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091926.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091926.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085698.1" } ] } }, { "isoform_ac": "A0AAA9TQH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0AAA9TQH7-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQELVLWQVFPMTFTSSNQKYSRRDDDKMNG", "length": 1381, "header": "tr|A0AAA9TQH7-1|A0AAA9TQH7_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56293066, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092157.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092157.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100623.1" } ] } }, { "isoform_ac": "A0AAA9TTH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0AAA9TTH2-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQSCCLAH", "length": 1393, "header": "tr|A0AAA9TTH2-1|A0AAA9TTH2_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56344652, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101061.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101061.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101928.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101928.1" } ] } }, { "isoform_ac": "A0ABI0NMY4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#A0ABI0NMY4-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQVRQRRPEDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQLRCVKTYRVPPVQPASPGSHNALRLARLIWTSNRNVILMAHDGKEHRFMV", "length": 1461, "header": "tr|A0ABI0NMY4-1|A0ABI0NMY4_BOVIN Computationally mapped isoform of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=1 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56351746, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152556.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152556.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106599.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106599.1" } ] } }, { "isoform_ac": "E1BEC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1/entry#E1BEC1-1", "sequence": { "sequence": "MAGNSLVLPIVLWGRRAPTHCISAVLLTDDGATVVTGCHDGQICLWDLSVDLDVNPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGSQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDLQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYRLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDRTDKELLICPPVTRFFYGCKEYFHKLLIQGDSSGRLNIWNISDTPDKPEGNGGLEMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRSKVTCLLYPHQASARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAAPAAVDSLSHPAINLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTTLISPENLQKAPGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEDEDEEAVRQRREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAACKLSRGKAELGRRLAATEGVGKGTYGLSRAVTTQHLLSVISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLPKARGSPPTSSHIVQGQIKQVAAPVVSARSEADQSGSDPASTPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDTWAPYLPQYMDHVISPGVSAEALQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQLRCVKTYRVPPVQPASPGSHNALRLARLIWTSNRNVILMAHDGKEHRFMV", "length": 1490, "header": "tr|E1BEC1-1|E1BEC1_BOVIN Isoform 1 of WD repeat-containing protein 7 OS=Bos taurus OX=9913 GN=WDR7 PE=4 SV=4 CANONICAL=E1BEC1-1" }, "locus": { "chromosome": "24", "start_pos": 56351746, "end_pos": 56024272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005230.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005230.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005230.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005230.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536469", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536469", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BEC1", "url": "https://www.uniprot.org/uniprotkb/E1BEC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1168, "end_pos": 1170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1238, "end_pos": 1240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1425, "end_pos": 1427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" }, { "start_pos": 906, "end_pos": 908, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEC1" }, { "id": "PF23123", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23123" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WDR72-like alpha-solenoid", "eco_id": "ECO_0000259", "start_pos": 1014, "end_pos": 1055, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1168, "end_pos": 1170 }, { "start_pos": 1238, "end_pos": 1240 }, { "start_pos": 1425, "end_pos": 1427 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 524, "end_pos": 526 }, { "start_pos": 682, "end_pos": 684 }, { "start_pos": 711, "end_pos": 713 }, { "start_pos": 794, "end_pos": 796 }, { "start_pos": 906, "end_pos": 908 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEH5-1", "uniprot_ac": "E1BEH5", "uniprot_id": "E1BEH5_BOVIN", "mass": { "chemical_mass": 26463.0, "monoisotopic_mass": 26463.0 }, "refseq": { "ac": "NP_001193226", "name": "transmembrane protein 174", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193226" }, "gene_names": [ { "name": "TMEM174", "type": "recommended", "evidence": [ { "id": "E1BEH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH5" } ] }, { "name": "TMEM174", "type": "synonym", "evidence": [ { "id": "NP_001193226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193226" } ] } ], "protein_names": [ { "name": "Transmembrane protein 174", "type": "synonym", "evidence": [ { "id": "E1BEH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEH5/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 174", "type": "synonym", "evidence": [ { "id": "NP_001193226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193226" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEH5", "url": "https://www.uniprot.org/uniprotkb/E1BEH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM174", "url": "https://www.uniprot.org/uniprotkb/E1BEH5", "locus": { "chromosome": "20", "start_pos": 8447512, "end_pos": 8448477, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003377", "url": "https://www.ensembl.org/id/ENSBTAG00000003377" } ] } } ], "crossref": [ { "id": "E1BEH5", "url": "https://alphafold.ebi.ac.uk/entry/E1BEH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003377", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003377", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618642", "url": "https://www.ncbi.nlm.nih.gov/gene/618642", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618642", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618642", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YYTIYPP", "url": "https://omabrowser.org/oma/group/YYTIYPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEH5", "url": "https://www.orthodb.org/?gene=E1BEH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31020:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31020:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193226", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEH5", "url": "https://www.uniprot.org/uniprotkb/E1BEH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEH5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQGCSRMEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGVTFTIMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQWCKESEERLPDPEQTAGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPMGMNTTYLQPVVSPCGLIPTGGLAATMPSPPQYYTIYPPENAAFVDDQDYPSFADTADGRSSPDAEQLEETPLGDEDSACFSPPPYEEICSPPR", "length": 243, "header": "tr|E1BEH5-1|E1BEH5_BOVIN Isoform 1 of Transmembrane protein 174 OS=Bos taurus OX=9913 GN=TMEM174 PE=4 SV=1 CANONICAL=E1BEH5-1" }, "isoforms": [ { "isoform_ac": "E1BEH5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEH5/entry#E1BEH5-1", "sequence": { "sequence": "MEQGCSRMEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGVTFTIMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQWCKESEERLPDPEQTAGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPMGMNTTYLQPVVSPCGLIPTGGLAATMPSPPQYYTIYPPENAAFVDDQDYPSFADTADGRSSPDAEQLEETPLGDEDSACFSPPPYEEICSPPR", "length": 243, "header": "tr|E1BEH5-1|E1BEH5_BOVIN Isoform 1 of Transmembrane protein 174 OS=Bos taurus OX=9913 GN=TMEM174 PE=4 SV=1 CANONICAL=E1BEH5-1" }, "locus": { "chromosome": "20", "start_pos": 8448443, "end_pos": 8447525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004379.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004379.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004379.2", "url": "https://www.ensembl.org/id/ENSBTAP00000004379.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618642", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618642", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YKI0-1", "protein_name": "Transmembrane protein 174", "gene_name": "TMEM174", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQNNSSVEDFSLNVFSVTPYPPSRSDALVSDGDKAGATLLFSGVFLGLVGITFTVMGWIKYDGLTHLEWTQLLGPILLSVGVTFILIAVCKFNMLTCKPCKEREENMLDIDQSSSGQSFVFTGINQPITFHGATVVQYIPPPYPALDSAAASPGYLHPVLSCCGAVSPGVSPIPSPSSAHFCPAYSLDNPAFTWDESCASYLAESTRNTRPEDSSDEPEELLEDPCEELSPPRYEEIYPLSS", "length": 243 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S2L3-1", "protein_name": "Transmembrane protein 174", "gene_name": "TMEM174", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTMEQGHNRVEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTIMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCKESEERVPDLEQTAGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMTTTYLQPVVSPCGLVPPGGLAAAMPSPPQYYTIYPPENAAFVHDQDYPSFVDAGDDRSSPDAEQLEETQLGDEDSTCFSPPPYEEICSLPR", "length": 246 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I0G3-1", "protein_name": "Transmembrane protein 174", "gene_name": "Tmem174", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEHNTSSSEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCTESEERVLDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYASQEPLGMNAAYLQPMMNPCGLVPSSGAVAAAPSPPQYYTIYPQDNAAFVENEGYPPFVAVGNDRPSSDADQLEGMQMEEEDCVHFSPPPYEEIYALPR", "length": 243 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q68FU0-1", "protein_name": "Transmembrane protein 174", "gene_name": "Tmem174", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQSSNRPEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILISVCKFKMLSCQLCTDNEERVLDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMNTTYLQPMMNPCGLVPSSGAVAATPSPPQYYTIYPQDNAAFVESEGFSPFVGAGHDRPSSDADQLEGTQMGEEERVCFSPPPYEEIYALPR", "length": 243 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WUU8-1", "protein_name": "Transmembrane protein 174", "gene_name": "TMEM174", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQGSGRLEDFPVNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPVLLSVGVTFILIAVCKFKMLSCQLCKESEERVPDSEQTPGGPSFVFTGINQPITFHGATVVQYIPPPYGSPEPMGINTSYLQSVVSPCGLITSGGAAAAMSSPPQYYTIYPQDNSAFVVDEGCLSFTDGGNHRPNPDVDQLEETQLEEEACACFSPPPYEEIYSLPR", "length": 243 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCX7-1", "protein_name": "Transmembrane protein 174", "gene_name": "Tmem174", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEHSSNRPEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCSDNEERVPDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMNATYLQPMMNPCGLIPPSGAAAAAPSPPQYYTIYPQDNAAFVESEGFSPFVGTGYDRPDSDADQLEGTELEEEDCVCFSPPPYEEIYALPR", "length": 243 }, "evidence": [ { "id": "E1BEH5", "url": "https://omabrowser.org/oma/group/E1BEH5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BEH5", "url": "https://www.uniprot.org/uniprotkb/E1BEH5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1BEH5", "url": "https://www.uniprot.org/uniprotkb/E1BEH5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphate ion homeostasis", "id": "GO:0055062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055062", "evidence": [ { "database": "UniProtKB", "id": "E1BEH5", "url": "https://www.uniprot.org/uniprotkb/E1BEH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 243, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEI5-1", "uniprot_ac": "E1BEI5", "uniprot_id": "E1BEI5_BOVIN", "mass": { "chemical_mass": 35468.0, "monoisotopic_mass": 35468.0 }, "refseq": { "ac": "NP_001193669", "name": "olfactory receptor 4D5", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193669" }, "gene_names": [ { "name": "OR4D5", "type": "recommended", "evidence": [ { "id": "E1BEI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ] }, { "name": "OR4D5", "type": "synonym", "evidence": [ { "id": "NP_001193669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193669" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 4 subfamily D member 5", "type": "synonym", "evidence": [ { "id": "E1BEI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4D5", "type": "synonym", "evidence": [ { "id": "NP_001193669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193669" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001193669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193669" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4D5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5", "locus": { "chromosome": "29", "start_pos": 26588467, "end_pos": 26587523, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006634", "url": "https://www.ensembl.org/id/ENSBTAG00000006634" } ] } } ], "crossref": [ { "id": "E1BEI5", "url": "https://alphafold.ebi.ac.uk/entry/E1BEI5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504624", "url": "https://www.ncbi.nlm.nih.gov/gene/504624", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504624", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504624", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFMTVVG", "url": "https://omabrowser.org/oma/group/YFMTVVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEI5", "url": "https://www.orthodb.org/?gene=E1BEI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTANHSQVTGFVLLGFSQVWELRLFFFIVFSVVYLMTVTGNLLIVAVVTSDPRLHTTMYFLLGNLSFLDFCYSSIMAPRMLADLLSRKPVISFGGCLTQLFFFHFIGGIKIFLLTVMVYDRYVAISQPLRYMLIMNRTVCGLLVAASWVGGFIHSIAQVGLTAQLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGSYTALLVMLRSHSREGRSKALSTCASHIAVVTLIFVPCLYIYARPFRTFPMDKVVSVLYTMVTPMLNPAIYTLRNKEVIIAMKKLWRRQKDLLDPLEH", "length": 314, "header": "tr|E1BEI5-1|E1BEI5_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily D member 5 OS=Bos taurus OX=9913 GN=OR4D5 PE=3 SV=3 CANONICAL=E1BEI5-1" }, "isoforms": [ { "isoform_ac": "E1BEI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEI5/entry#E1BEI5-1", "sequence": { "sequence": "MTTANHSQVTGFVLLGFSQVWELRLFFFIVFSVVYLMTVTGNLLIVAVVTSDPRLHTTMYFLLGNLSFLDFCYSSIMAPRMLADLLSRKPVISFGGCLTQLFFFHFIGGIKIFLLTVMVYDRYVAISQPLRYMLIMNRTVCGLLVAASWVGGFIHSIAQVGLTAQLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGSYTALLVMLRSHSREGRSKALSTCASHIAVVTLIFVPCLYIYARPFRTFPMDKVVSVLYTMVTPMLNPAIYTLRNKEVIIAMKKLWRRQKDLLDPLEH", "length": 314, "header": "tr|E1BEI5-1|E1BEI5_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily D member 5 OS=Bos taurus OX=9913 GN=OR4D5 PE=3 SV=3 CANONICAL=E1BEI5-1" }, "locus": { "chromosome": "29", "start_pos": 26588464, "end_pos": 26587523, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008715.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008715.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008715.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008715.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504624", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504624", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZLT4-1", "protein_name": "Olfactory receptor family 4 subfamily D member 5", "gene_name": "Or4d5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNPANHSQVATFVLLGLSQVWELRLLFFTVFSAVYLLTVAGNLLIVAIVTSDPRLHTTMYFLLGNLSFLDFCYSSITAPRMLVDLLSHNPTISFGACLTQLFFFHFIGGIKIFLLTVMAYDRYIAICQPLRYTVIMNQTVCGLFMGASWVGGFIHSIVQIGLTIHLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGPYTALLVMLRSHSKEGRSKALSTCASHIAVVTIIFVPCIYIYARPFRTFPMDKAVSVLYTMVTPMLNPAIYTLRNKEVIAAMKKLWRRQKDFLGPSDH", "length": 314 }, "evidence": [ { "id": "E1BEI5", "url": "https://omabrowser.org/oma/group/E1BEI5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S9N3-1", "protein_name": "Olfactory receptor family 4 subfamily D member 5", "gene_name": "OR4D5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPTNHSQVTGFVLLGLSQVWELRFFFFIVFSVVYLMTVTGNLLIVAIVTSDPRLHTTMYFLLGNLSFLDFCYSSITAPRMLVDLLLGNPIISFGGCLTQLFFFHFIGGIKIFLLTVMAYDRYVAISQPLRYTLIMNRTVCGLLMAASWVGGFIHSIVQVGLTMKLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLLCFLVLLGSYTALLVMLQSHSREGRSKALSTCASHIAVVTLIFVPCVYIYARPFRTFPMDKVVSVLYTMVTPMLNPAIYTLRNKEVIMAMKKLWRRQKDPLGSFEH", "length": 314 }, "evidence": [ { "id": "E1BEI5", "url": "https://omabrowser.org/oma/group/E1BEI5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NGN0-1", "protein_name": "Olfactory receptor 4D5", "gene_name": "OR4D5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPANHSQVAGFVLLGLSQVWELRFVFFTVFSAVYFMTVVGNLLIVVIVTSDPHLHTTMYFLLGNLSFLDFCYSSITAPRMLVDLLSGNPTISFGGCLTQLFFFHFIGGIKIFLLTVMAYDRYIAISQPLHYTLIMNQTVCALLMAASWVGGFIHSIVQIALTIQLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGSYTALLVMLRSHSREGRSKALSTCASHIAVVTLIFVPCIYVYTRPFRTFPMDKAVSVLYTIVTPMLNPAIYTLRNKEVIMAMKKLWRRKKDPIGPLEHRPLH", "length": 318 }, "evidence": [ { "id": "E1BEI5", "url": "https://omabrowser.org/oma/group/E1BEI5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VFN1-1", "protein_name": "Olfactory receptor family 4 subfamily D member 5", "gene_name": "Or4d5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNPANHSQVATFFLLGLSQVWELRFLFFTVFSAVYLLTVTGNLLIVAIVTSDPRLHTTMYFLLGNLSFLDFCYSSITAPRMLVDLLSHSPTISFGACLTQLFFFHFIGGIKIFLLTVMAYDRYIAISQPLRYTLIMNQTVCGIFMAASWVGGFIHSIVQVGLTIHLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGSYTALLVMLRSHSKEGRSKALSTCASHITVVTIIFVPCIYIYARPFRTFPMDKAVSVLYTMVTPMLNPAIYTLRNKEVIVAMKKLWRRKKDFLGSSDH", "length": 314 }, "evidence": [ { "id": "E1BEI5", "url": "https://omabrowser.org/oma/group/E1BEI5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BEI5", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEI5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEI5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEI5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEJ2-1", "uniprot_ac": "E1BEJ2", "uniprot_id": "E1BEJ2_BOVIN", "mass": { "chemical_mass": 86049.0, "monoisotopic_mass": 86049.0 }, "refseq": { "ac": "NP_001179907", "name": "proprotein convertase subtilisin/kexin type 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179907" }, "gene_names": [ { "name": "PCSK7", "type": "recommended", "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ] }, { "name": "PCSK7", "type": "synonym", "evidence": [ { "id": "NP_001179907", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179907" } ] } ], "protein_names": [ { "name": "Proprotein convertase subtilisin/kexin type 7", "type": "recommended", "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#names_and_taxonomy" } ] }, { "name": "Prohormone convertase 7", "type": "synonym", "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#names_and_taxonomy" } ] }, { "name": "Proprotein convertase 7", "type": "synonym", "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#names_and_taxonomy" } ] }, { "name": "Subtilisin/kexin-like protease PC7", "type": "synonym", "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#names_and_taxonomy" } ] }, { "name": "proprotein convertase subtilisin/kexin type 7", "type": "synonym", "evidence": [ { "id": "NP_001179907", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179907" } ] } ], "function": [ { "annotation": "Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2#function" }, { "database": "UniProtKB", "id": "ARBA00054142", "url": "https://www.uniprot.org/uniprotkb/ARBA00054142#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ95#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCSK7", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2", "locus": { "chromosome": "15", "start_pos": 27895050, "end_pos": 27924398, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003052", "url": "https://www.ensembl.org/id/ENSBTAG00000003052" } ] } } ], "crossref": [ { "id": "E1BEJ2", "url": "https://alphafold.ebi.ac.uk/entry/E1BEJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003052", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003052", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515398", "url": "https://www.ncbi.nlm.nih.gov/gene/515398", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515398", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515398", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NGRMPFY", "url": "https://omabrowser.org/oma/group/NGRMPFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEJ2", "url": "https://www.orthodb.org/?gene=E1BEJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16470", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16470", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9768727", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179907", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKGRQKVPHSDAPLGLPTGLWLELAGLFLLLPWVMGLVGAGGPRAQGPRGLSWAVRLDGPEGEGAEESLERRADALAQATGLMNAGRIGELQGHYLLVQPAGHRQARQVKAIRQQVEAVLARHEAVRWHSEQRLLKRTKRGVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDLENGNHHGTRCAGEIAAVPNNSFCAVGVAFGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRHADWITNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPLSARPLEVLWNVSRMDLDMSGLKTLEHVAVTISITHPRRGSLEVKLFCPSGMMSLIGAPRSLDSDPNGFNDWTFSTVRCWGERAKGTYRLVIRDVGDETSQAGVLRQWQLTLYGSVWSPVDIRDRQRLLESAMSGKYLHDGFTLPCPPGLNIPEEDGYTITPNTLKTLVLIGCFTVFWTIYYTLEVYLSQRNVAFGPICRSGPCHWPQRSQKAKEEGTELESMPLCSSQDPGGVGLESEGSPTTSRLHAPDLLDQGDWSLSQSRGALDVPQLLPPDLLQGKEAQMC", "length": 786, "header": "tr|E1BEJ2-1|E1BEJ2_BOVIN Isoform 1 of Proprotein convertase subtilisin/kexin type 7 OS=Bos taurus OX=9913 GN=PCSK7 PE=3 SV=1 CANONICAL=E1BEJ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNP8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#A0AAA9SNP8-1", "sequence": { "sequence": "MPKGRQKVPHSDAPLGLPTGLWLELAGLFLLLPWVMGLVGAGGPRAQGPRGLSWAVRLDGPEGEGAEESLERRADALAQATGLMNAGRIGELQGHYLLVQPAGHRQARQVKAIRQQVEAVLARHEAVRWHSEQRLLKRTKRGVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDLENGNHHGTRCAGEIAAVPNNSFCAVGVAFGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRHADWITNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPLSARPLEVLWNVSRMDLDMSGLKTLEHVAVTISITHPRRGSLEVKLFCPSGMMSLIGAPRSLDSRRDVPGRRPPAMAAHPVWLCVESSRHQRQTEAARKCHEWEIPARRLHAALPARAEHPRGRRLYHHPQHSQDPGADWLLHRLLDHLLHAGSILEPEECGLWPNLSEWTVPLAPAKPESQGGRDRTRINAPLQQPGSRWSGAGERGLSHHLKAPRPRPAGSGGLEPVPEQGCLGRPSAPAPRPAAGEGGADVLTWGLTATVGWALTS", "length": 769, "header": "tr|A0AAA9SNP8-1|A0AAA9SNP8_BOVIN Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 7 OS=Bos taurus OX=9913 GN=PCSK7 PE=3 SV=1 CANONICAL=E1BEJ2-1" }, "locus": { "chromosome": "15", "start_pos": 27921988, "end_pos": 27896128, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109725.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109725.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087953.1" } ] } }, { "isoform_ac": "A0AAA9TJ95-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#A0AAA9TJ95-1", "sequence": { "sequence": "MPKGRQKVPHSDAPLGLPTGLWLELAGLFLLLPWVMGLVGAGGPRAQGPRGLSWAVRLDGPEGEGAEESLERRADALAQATGLMNAGRIGELQGHYLLVQPAGHRQARQVKAIRQQVEAVLARHEAVRWHSEQRLLKRTKRGVHFNDPKYPQQWHLSPEGSYDLNSNDPDPMPHPDLENGNHHGTRCAGEIAAVPNNSFCAVGVAFGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRHADWITNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPLSARPLEVLWNVSRMDLDMSGLKTLEHVAVTISITHPRRGSLEVKLFCPSGMMSLIGAPRSLDSDPNGFNDWTFSTVRCWGERAKGTYRLVIRDVGDETSQAGVLRQWQLTLYGSVWSPVDIRDRQRLLESAMSGKYLHDGFTLPCPPGLNIPEEDGYTITPNTLKTLVLIGCFTVFWTIYYTLEVYLSQRNVAFGPICRSGPCHWPQRSQKAKEEGTELESMPLCSSQDPGGVGLESEGSPTTSRLHAPDLLDQGDWSLSQSRGALDVPQLLPPDLLQGKEAQMC", "length": 741, "header": "tr|A0AAA9TJ95-1|A0AAA9TJ95_BOVIN Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 7 OS=Bos taurus OX=9913 GN=PCSK7 PE=3 SV=1 CANONICAL=E1BEJ2-1" }, "locus": { "chromosome": "15", "start_pos": 27921988, "end_pos": 27896172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098528.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098528.1" } ] } }, { "isoform_ac": "E1BEJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2/entry#E1BEJ2-1", "sequence": { "sequence": "MPKGRQKVPHSDAPLGLPTGLWLELAGLFLLLPWVMGLVGAGGPRAQGPRGLSWAVRLDGPEGEGAEESLERRADALAQATGLMNAGRIGELQGHYLLVQPAGHRQARQVKAIRQQVEAVLARHEAVRWHSEQRLLKRTKRGVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDLENGNHHGTRCAGEIAAVPNNSFCAVGVAFGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRHADWITNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPLSARPLEVLWNVSRMDLDMSGLKTLEHVAVTISITHPRRGSLEVKLFCPSGMMSLIGAPRSLDSDPNGFNDWTFSTVRCWGERAKGTYRLVIRDVGDETSQAGVLRQWQLTLYGSVWSPVDIRDRQRLLESAMSGKYLHDGFTLPCPPGLNIPEEDGYTITPNTLKTLVLIGCFTVFWTIYYTLEVYLSQRNVAFGPICRSGPCHWPQRSQKAKEEGTELESMPLCSSQDPGGVGLESEGSPTTSRLHAPDLLDQGDWSLSQSRGALDVPQLLPPDLLQGKEAQMC", "length": 786, "header": "tr|E1BEJ2-1|E1BEJ2_BOVIN Isoform 1 of Proprotein convertase subtilisin/kexin type 7 OS=Bos taurus OX=9913 GN=PCSK7 PE=3 SV=1 CANONICAL=E1BEJ2-1" }, "locus": { "chromosome": "15", "start_pos": 27921988, "end_pos": 27896172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040088.5", "url": "https://www.ensembl.org/id/ENSBTAT00000040088.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039868.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039868.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 531, "start_aa": "Thr", "end_pos": 531, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr531", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515398", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515398", "resource": "KEGG Pathway" }, { "id": "R-BTA-9768727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "resource": "Reactome", "description": "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SX84-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "PCSK7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKGRQKVPHSDAPLGLPARLWLELAGLFLLLPWVMGLVGAGGPGAQGPGGLSWAVHLDHPEGEGEADLLEQQADALAQAAGLVNAGRIGELQGHYLLVQPAGHPQPQQAEAVRQQVEAVLARHEAVRWHSEQRLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDRHADWITNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKEDKAIPLSARPLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLEVKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDEKSQAGILRQWQLTLYGSVWSPVDIRDRQRLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLIGCFTVFWTIYYMLEVYLSQRNVASHPVCRSGPCHWPQQSRKAKEEGTELEAVPLCSSQDPGGVGTESEGPSAPSRLRAPDLLDQGDWSLSQNRGALDCPQRLPPDLLQGKGEQIC", "length": 786 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M1P8P5-1", "protein_name": "3.4.21.-", "gene_name": "pcsk7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASCSSRVCLGLYPLLLLFSSSSSSCAPGRSWAVQLQPDSLSSAGSPDLLAQAVAQDVGLRSHGQIGQLEGHYLLCQDPAQGEDWRWMEAALDRHPHVAWHSQENVLRRSKRSVHFNDPKFPSQWHLHNDMKRGMDINVTGVWERNITGAGVTVVVVDDGIQHNLADIQPNYSPEGSYDLNSNDPDPMPHPDGPSDNHHGTRCAGEIAAVSNNSFCAVGVAYGSRVAGIRVLDGPLTDSMEAIAFNKHYQVNDIYSCSWGPDDDGRTVDGPHPLGKAALQHGVIAGRKGFGSIFIVASGNGGQNQDNCNYDGYANSIYTVTIGAVDESGRKPTYAEECASMLAVTFSSGNTPLRSIVTSDWSLQSGTGCTSGHTGTSAAAPLAAGMVALMLQVRPCLSWRDVQHIITYTATQHDLQADWVTNGAGFHHSHKYGFGLLNAWRLVNAAKVWESVPFLVSYQSPVLRVNEVITTSTNLTQTWNVSESDLQRSGMQTLEHVSVTLSIQHPRRGNLQILLLCPSGISSLIGARRALDVDSAGLTDWTFSTVRCWGEQAEGQYSLLIMDDAPLSSGILKSWKLTLYGSSLSHQQVTDRQRVVEEAMSGHYLSSSFSLPCPPGIDVPAEIVNPFTSSSLKSLLLLGCFTLFWSLYYTLEVVLTHWDWRGGCVRGRDGDAGYSRLSRDEAQTDPQQVEVLLETHSQDKVLLIADTHT", "length": 709 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZRB7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "PCSK7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPHRERRLRRWSAGAQAVRCVHTCLWLGAAWIPSVLSHGLTRGTELDDGRAVAHGPGELAWAVSLDVPEEQVEQRAEQLARTAGLVNMGRIGELKGHYLFSYRPDSHAAPEPEAIRRSVDTLFAQHDSVRWHSEQKLLKRSKRSLHFNDPKYPQQWHLNNRKSPGKDINVTGVWERNVTGRGVTVVVVDDGVEHTIKDIQPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCTVGVAYGSRIAGIRVLDGPLTDSMEAIAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRRGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEMGSMPFYAEECASMLAVTFSGGDKMMRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATKYEDRHAKWDVNRAGFSHSHQHGFGLLNAWRLVNAAKIWESVPYLASYVSPVLKEGRSIPLLPQELEATWNVTTTDLQLSGMRTLEHVAVTVTITHPRRGNLEIRLFCPSGMMSLIGTTRSMDSDPNGFADWTFSTVRCWGEEAQGTYRLVIRDTGDQSLRPGTLKQWQLTLYGSSWSPAEMKERQRLLEEAMSGQYLNNDFSLPCPPGLEIPEQQHYTITANTLKTLLLLGCFAVFWTFYYMLEVCLSRNNVGLDLTCHGSTACRWYQQGGKHRALENGLEMESVPLYREKEVEDIEVECELLEPVQEDTGEEGSWTPTLPKLPASSRAAAPTTAGYLGREAAAELLADDRELQTC", "length": 799 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IAK2-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "Pcsk7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKGRQKVPHLDAPLGLPICLWLELAGLLFMVPWVMGLSEASGLDSLGAGGLSWAVHLDSLEGERKEESLMQQADALAQAAGLVNAGRIGELQGHYLLVQPAGHKQAMEVEAMRQQAEAVLAQHEAVRWHSEQKLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDAENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDIQHIIVFTATQYEDHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAVPRSPNSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLAIRDVGDEPLQVGILRQWQLTLYGSMWSPVDIKDRQSLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTIYYMLEIYLSQRNMASTQGCRSGHCPWPQRSQNSREVGTELESVPLCNSKDQDGVDSENGSCTATSTFLTPELLRERDWNLSQSSKSILDCPQHQPPDLLQGKDGQIC", "length": 787 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16549-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "PCSK7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC", "length": 785 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61139-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "Pcsk7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKGRQKVPHLDAHLGLPICLWLELAIFFLVPQVMGLSEAGGLDILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAGRIGELQGHYLFVQPTGHRQAMEVEAMRQQAEAVLARHEAVRWHSEQTLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYEDHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSPVDIKDRQSLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRNKASTHGCRKGCCPWAPRRQNSKDAGTALESMPLCSSKDLDGVDSEHGDCTTASSFLAPELDCPPHQPPDLLQGKSGQIC", "length": 770 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q62849-1", "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "Pcsk7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGRQKVPRLDARLGLPICLCLELAIFFLVPQVMGLTEAGGLDTLGAGGLSWAVHLDSLEGERKEESLIQQANAVAQAAGLVNAGRIGELQGHYLFVQPAGHGQAMEAEAMRQQAEAVLAKHEAVRWHSEQRLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDHRADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGVYRLVIRDVGDEPLQVGILQQWQLTLYGSTWSPVDIKDRQSLLESAMSGKYLHDDFTLPCPPGLKIPEEDGYSITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRSKASTHGCRRGCCPWPPQSQNSKEVGTALESMPLCSSKDLDGVDSEHGDCTTASSLLAPELLGEADWSLSQNSKSDLDCPPHQPPDLKDGQIC", "length": 783 }, "evidence": [ { "id": "E1BEJ2", "url": "https://omabrowser.org/oma/group/E1BEJ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ2", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEJ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 786, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEJ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEJ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ2" }, { "id": "PS51829", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P/Homo B", "eco_id": "ECO_0000259", "start_pos": 481, "end_pos": 618, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 531 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 511, "end_pos": 513 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEJ5-1", "uniprot_ac": "E1BEJ5", "uniprot_id": "E1BEJ5_BOVIN", "mass": { "chemical_mass": 48493.0, "monoisotopic_mass": 48493.0 }, "refseq": {}, "gene_names": [ { "name": "LOC104968476", "type": "recommended", "evidence": [ { "id": "E1BEJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ] } ], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BEJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC104968476", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000003447", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003447", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KCYMCSE", "url": "https://omabrowser.org/oma/group/KCYMCSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9843940", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEJ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQVRIPKAGMFSQKAHFCDLDLGDVLHLTEHQRQKLYDIGAWEKHLYFSVKYQPRKQHTGEKYLRSKMGKASFMTNCRLFVLGKSLSCGESTQTRDKSNRRTECGAAFHRGKTHYSPGECTEDFSCRHILSQHQRVLTREKCYTCNECGKSFSKSYSLNDHWRVHTGEKPYECGECGKSFRQSSSLIQHRRVHTGARPHECDECGKLFSNKSNLIKHRRIHTGERPYECSECGKSFSESSALLQHRSVHTGERPYECSECGKFFTYHSSLIKHQRVHSGSRPYECNECGKSFTQNSSLIEHRRVHSGERPYKCSECGKSFSQSSALLQHRRVHTGERPYECNECGKFFTYSSSLLKHQRVHTGSRPYECSECGKSFTQNSSLIKHRRIHTGERPYECSECGKSFSHSSSLIKHRRVHTC", "length": 420, "header": "tr|E1BEJ5-1|E1BEJ5_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC104968476 PE=3 SV=2 CANONICAL=E1BEJ5-1" }, "isoforms": [ { "isoform_ac": "E1BEJ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5/entry#E1BEJ5-1", "sequence": { "sequence": "MSQVRIPKAGMFSQKAHFCDLDLGDVLHLTEHQRQKLYDIGAWEKHLYFSVKYQPRKQHTGEKYLRSKMGKASFMTNCRLFVLGKSLSCGESTQTRDKSNRRTECGAAFHRGKTHYSPGECTEDFSCRHILSQHQRVLTREKCYTCNECGKSFSKSYSLNDHWRVHTGEKPYECGECGKSFRQSSSLIQHRRVHTGARPHECDECGKLFSNKSNLIKHRRIHTGERPYECSECGKSFSESSALLQHRSVHTGERPYECSECGKFFTYHSSLIKHQRVHSGSRPYECNECGKSFTQNSSLIEHRRVHSGERPYKCSECGKSFSQSSALLQHRRVHTGERPYECNECGKFFTYSSSLLKHQRVHTGSRPYECSECGKSFTQNSSLIKHRRIHTGERPYECSECGKSFSHSSSLIKHRRVHTC", "length": 420, "header": "tr|E1BEJ5-1|E1BEJ5_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC104968476 PE=3 SV=2 CANONICAL=E1BEJ5-1" }, "locus": { "chromosome": "18", "start_pos": 65143286, "end_pos": 65142027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108919.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108919.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099632.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099632.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9843940", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "resource": "Reactome", "description": "Regulation of endogenous retroelements by KRAB-ZFP proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13106-1", "protein_name": "Zinc finger protein 154", "gene_name": "ZNF154", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLDVHHQKQHLGEKHFRSNVGRALFVKTCTFHVSGEPSTCREVGKDFLAKLGFLHQQAAHTGEQSNSKSDGGAISHRGKTHYNCGEHTKAFSGKHTLVQQQRTLTTERCYICSECGKSFSKSYSLNDHWRLHTGEKPYECRECGKSFRQSSSLIQHRRVHTAVRPHECDECGKLFSNKSNLIKHRRVHTGERPYECSECGKSFSQRSALLQHRGVHTGERPYECSECGKFFTYHSSLIKHQKVHSGSRPYECSECGKSFSQNSSLIEHHRVHTGERPYKCSECGKSFSQRSALLQHRGVHTGERPYECSECGKFFPYSSSLRKHQRVHTGSRPYECSECGKSFTQNSGLIKHRRVHTGEKPYECTECGKSFSHNSSLIKHQRIHSR", "length": 437 }, "evidence": [ { "id": "E1BEJ5", "url": "https://omabrowser.org/oma/group/E1BEJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BEJ5", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEJ5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 144, "end_pos": 171, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 380, "end_pos": 382 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEK0-1", "uniprot_ac": "E1BEK0", "uniprot_id": "E1BEK0_BOVIN", "mass": { "chemical_mass": 39400.0, "monoisotopic_mass": 39400.0 }, "refseq": {}, "gene_names": [ { "name": "NNMT", "type": "recommended", "evidence": [ { "id": "E1BEK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK0" } ] } ], "protein_names": [ { "name": "Nicotinamide N-methyltransferase", "type": "recommended", "evidence": [ { "id": "E1BEK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEK0", "url": "https://www.uniprot.org/uniprotkb/E1BEK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NNMT", "url": "https://www.uniprot.org/uniprotkb/E1BEK0", "locus": {} } ], "crossref": [ { "id": "E1BEK0", "url": "https://alphafold.ebi.ac.uk/entry/E1BEK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008564", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008564", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511161", "url": "https://www.ncbi.nlm.nih.gov/gene/511161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511161", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511161", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLEYSCE", "url": "https://omabrowser.org/oma/group/CLEYSCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEK0", "url": "https://www.orthodb.org/?gene=E1BEK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10867", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10867", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10867:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10867:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01234", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01234", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156581", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156581", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-196807", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196807", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BEK0", "url": "https://www.uniprot.org/uniprotkb/E1BEK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEK0-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQKRLTLPNKPELLKSLGAGEGNWRGEWPKGGRFRKHPLLAALVFIPVFVLRAGGRTKSEPHKEGPRESVCLLLLPEQNSLLSMALQERQEPDVYQENFEPTSYLEYYRMNQDPVGDEVLHFLLKHYNATFKPGGLEGKLLIDIGSGPTIYQFLSACESFQEIIATDYTDKNLQELEKWLKKMPGAFDWSPVVKYVCELEGNRDKWAEKEERVRRAVTQVLKCDVLKERPLEPAVLPPADGLISSLCLEAACPTPQACRDALRHLRTLLRPGGHLVLSGGFETTFFMVGDKRFSTLPLNEKFLREALQEAGFIIEKLEKVTRAAETHLDNRSDYTGLFFLVARRGD", "length": 347, "header": "tr|E1BEK0-1|E1BEK0_BOVIN Isoform 1 of Nicotinamide N-methyltransferase OS=Bos taurus OX=9913 GN=NNMT PE=1 SV=2 CANONICAL=E1BEK0-1" }, "isoforms": [ { "isoform_ac": "E1BEK0-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK0/entry#E1BEK0-1", "sequence": { "sequence": "MEQKRLTLPNKPELLKSLGAGEGNWRGEWPKGGRFRKHPLLAALVFIPVFVLRAGGRTKSEPHKEGPRESVCLLLLPEQNSLLSMALQERQEPDVYQENFEPTSYLEYYRMNQDPVGDEVLHFLLKHYNATFKPGGLEGKLLIDIGSGPTIYQFLSACESFQEIIATDYTDKNLQELEKWLKKMPGAFDWSPVVKYVCELEGNRDKWAEKEERVRRAVTQVLKCDVLKERPLEPAVLPPADGLISSLCLEAACPTPQACRDALRHLRTLLRPGGHLVLSGGFETTFFMVGDKRFSTLPLNEKFLREALQEAGFIIEKLEKVTRAAETHLDNRSDYTGLFFLVARRGD", "length": 347, "header": "tr|E1BEK0-1|E1BEK0_BOVIN Isoform 1 of Nicotinamide N-methyltransferase OS=Bos taurus OX=9913 GN=NNMT PE=1 SV=2 CANONICAL=E1BEK0-1" }, "locus": { "chromosome": "15", "start_pos": 24812980, "end_pos": 24807815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040069.7", "url": "https://www.ensembl.org/id/ENSBTAT00000040069.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039849.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039849.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 255, "start_aa": "Thr", "end_pos": 255, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr255", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511161", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511161", "resource": "KEGG Pathway" }, { "id": "R-BTA-156581", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156581", "resource": "Reactome", "description": "Methylation" }, { "id": "R-BTA-196807", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196807", "resource": "Reactome", "description": "Nicotinate metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nicotinamide N-methyltransferase activity", "id": "GO:0008112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008112", "evidence": [ { "database": "UniProtKB", "id": "E1BEK0", "url": "https://www.uniprot.org/uniprotkb/E1BEK0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BEK0", "url": "https://www.uniprot.org/uniprotkb/E1BEK0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "E1BEK0", "url": "https://www.uniprot.org/uniprotkb/E1BEK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEK0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 347, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEK0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEK0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 255 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 331, "end_pos": 333 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEK1-1", "uniprot_ac": "E1BEK1", "uniprot_id": "E1BEK1_BOVIN", "mass": { "chemical_mass": 32743.0, "monoisotopic_mass": 32743.0 }, "refseq": { "ac": "NP_001106721", "name": "putative ribosome-binding factor A, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106721" }, "gene_names": [ { "name": "RBFA", "type": "recommended", "evidence": [ { "id": "E1BEK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ] }, { "name": "RBFA", "type": "synonym", "evidence": [ { "id": "NP_001106721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106721" } ] } ], "protein_names": [ { "name": "Ribosome binding factor A", "type": "synonym", "evidence": [ { "id": "E1BEK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK1/entry#names_and_taxonomy" } ] }, { "name": "putative ribosome-binding factor A, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001106721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106721" } ] }, { "name": "ribosome binding factor A (putative)", "type": "synonym", "evidence": [ { "id": "NP_001106721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106721" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBFA", "url": "https://www.uniprot.org/uniprotkb/E1BEK1", "locus": { "chromosome": "24", "start_pos": 491877, "end_pos": 504604, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000036297", "url": "https://www.ensembl.org/id/ENSBTAG00000036297" } ] } } ], "crossref": [ { "id": "E1BEK1", "url": "https://alphafold.ebi.ac.uk/entry/E1BEK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000036297", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000036297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510927", "url": "https://www.ncbi.nlm.nih.gov/gene/510927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCSRRLC", "url": "https://omabrowser.org/oma/group/HCSRRLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEK1", "url": "https://www.orthodb.org/?gene=E1BEK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14725", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14725", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14725:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14725:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02033", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02033", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001106721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106721", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWAALRGRPGLHLGLLSGARGLHSSPVSCGKNLLKKFASKTKKKFWYEGPSLGSHLTHKSSQLEFLTKSTSRRTRKEDQVRLRALNGLLYKALTDLLCTPEVSQELCDLNVELCKVSLTSDFSACRVFWRATLSEAQNAHTEAVLRRSAAHMRHLLMSQQTLRNVPPIVFVQDKKYAAVMEVDRLLAIADFGPRGEKEDFVQSDFSDPEALDAASPSDTLGPAAHLNLCGIDHEALNKQILEYKRRREQGHGSASPLWPEHVADLRKQMRRRKAKPHVDDDLSPKNYLQGGE", "length": 292, "header": "tr|E1BEK1-1|E1BEK1_BOVIN Isoform 1 of Ribosome binding factor A OS=Bos taurus OX=9913 GN=RBFA PE=4 SV=2 CANONICAL=E1BEK1-1" }, "isoforms": [ { "isoform_ac": "E1BEK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1/entry#E1BEK1-1", "sequence": { "sequence": "MWAALRGRPGLHLGLLSGARGLHSSPVSCGKNLLKKFASKTKKKFWYEGPSLGSHLTHKSSQLEFLTKSTSRRTRKEDQVRLRALNGLLYKALTDLLCTPEVSQELCDLNVELCKVSLTSDFSACRVFWRATLSEAQNAHTEAVLRRSAAHMRHLLMSQQTLRNVPPIVFVQDKKYAAVMEVDRLLAIADFGPRGEKEDFVQSDFSDPEALDAASPSDTLGPAAHLNLCGIDHEALNKQILEYKRRREQGHGSASPLWPEHVADLRKQMRRRKAKPHVDDDLSPKNYLQGGE", "length": 292, "header": "tr|E1BEK1-1|E1BEK1_BOVIN Isoform 1 of Ribosome binding factor A OS=Bos taurus OX=9913 GN=RBFA PE=4 SV=2 CANONICAL=E1BEK1-1" }, "locus": { "chromosome": "24", "start_pos": 504583, "end_pos": 492645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050795.4", "url": "https://www.ensembl.org/id/ENSBTAT00000050795.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047450.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047450.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510927", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510927", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZT82-1", "protein_name": "Ribosome binding factor A", "gene_name": "Rbfa", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLSNRTLLSWQRLHPSTVRLRHTRCRREAAADVPSALLTCEPSRILCAPAECAKISKRGCLNSVWLPWRKKFWYEAPSLGSHLTHKPSKYEFLTKNTLKKTRKEDTIRLRVLNGLLHKSLTELLCTPEVSQEVYDLNVELSKVSVTPDFSACRVYWKTGVSAEQNRHTEAVLQRSATYMRHLLISQQTLRNVPPIVFVQDKRDIVLAEVDRLLAVADFGPPDERDDLDGLRSPDAQAPHDSPEPTTHPNLCGIDHEALNKQIMEYKRKKERGLQCVSLAPPSGQEQAPDPAHLLRKRKKARSRQHQDASPRSFLLGEEDEDEDSSTEWECHAQEAEDEWEAEGGGEGVQQGLGGKREQG", "length": 360 }, "evidence": [ { "id": "E1BEK1", "url": "https://omabrowser.org/oma/group/E1BEK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P3B9-1", "protein_name": "Putative ribosome-binding factor A, mitochondrial", "gene_name": "Rbfa", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWAGVAGLRGSCAGLQALWGGHRAALLLGRSPALHTSVASCGSKNLLKKFASKTRKKFWYEGPSLGSHLTPRPSKHEFLTKTTSKKTRKEDSIRLRVLNGLLYKSLTELLCTPQVSQEVYDLNVELSKVSVTSDFSACRVYWKTGVSAEQNKHTESVLQRSAAYMRHLLISQQTLRNVPPIVFVQDKRDLVLAEVDRLLAEADFGPPDERDDLDGLRNADAQVPHDSPEPAAHPNLCGIDHEALNKQIMEYKRKKERGLQCQSLAPPSGREQAPEPTRLLRKREKVRSRWQHRDASPRSFLLGEEDEDEDSSTEWECHAHEAEDDDDHQEEELGADRGAQRGLCGKREQG", "length": 350 }, "evidence": [ { "id": "E1BEK1", "url": "https://omabrowser.org/oma/group/E1BEK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N0V3-1", "protein_name": "Putative ribosome-binding factor A, mitochondrial", "gene_name": "RBFA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWAAAGGLWRSRAGLRALFRSRDAALFPGCERGLHCSAVSCKNWLKKFASKTKKKVWYESPSLGSHSTYKPSKLEFLMRSTSKKTRKEDHARLRALNGLLYKALTDLLCTPEVSQELYDLNVELSKVSLTPDFSACRAYWKTTLSAEQNAHMEAVLQRSAAHMRHLLMSQQTLRNVPPIVFVQDKGNAALAELDQLLAVADFGPRDERDNFVQNDFRDPDAPQPCGTTEPTTSSSLCGIDHEALNKQIMEYKRRKDKGLGGLVWQGQVAELTTQMKKGRKRAKPRLEQDSSLKSYLSGEEVEDDLDLVGAPEYECYAPDTEELEAERGGGRTEDGHSCGASRE", "length": 343 }, "evidence": [ { "id": "E1BEK1", "url": "https://omabrowser.org/oma/group/E1BEK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "pmid": "" }, { "name": "mitochondrial small ribosomal subunit assembly", "id": "GO:0180026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180026", "evidence": [ { "database": "UniProtKB", "id": "E1BEK1", "url": "https://www.uniprot.org/uniprotkb/E1BEK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEK1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEK4-1", "uniprot_ac": "E1BEK4", "uniprot_id": "E1BEK4_BOVIN", "mass": { "chemical_mass": 162770.0, "monoisotopic_mass": 162770.0 }, "refseq": { "ac": "XP_024839036", "name": "helicase ARIP4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839036" }, "gene_names": [ { "name": "RAD54L2", "type": "recommended", "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ] }, { "name": "RAD54L2", "type": "synonym", "evidence": [ { "id": "XP_024839036", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839036" } ] } ], "protein_names": [ { "name": "Helicase ARIP4", "type": "recommended", "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4/entry#names_and_taxonomy" } ] }, { "name": "Androgen receptor-interacting protein 4", "type": "synonym", "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4/entry#names_and_taxonomy" } ] }, { "name": "RAD54-like protein 2", "type": "synonym", "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4/entry#names_and_taxonomy" } ] }, { "name": "helicase ARIP4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839036", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839036" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAD54L2", "url": "https://www.uniprot.org/uniprotkb/E1BEK4", "locus": { "chromosome": "22", "start_pos": 49169240, "end_pos": 49261983, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032253", "url": "https://www.ensembl.org/id/ENSBTAG00000032253" } ] } } ], "crossref": [ { "id": "ENSBTAG00000032253", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032253", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784245", "url": "https://www.ncbi.nlm.nih.gov/gene/784245", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784245", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784245", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SWAVDIM", "url": "https://omabrowser.org/oma/group/SWAVDIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEK4", "url": "https://www.orthodb.org/?gene=E1BEK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45797", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45797", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45797:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45797:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839036", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839036", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDESASGSDPDLDPDVELEDAEEEEEEEEEVAVEEHGRDDGEDLLDDPSLEDMCGTECAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKGLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLELFPEEIVLRASDGPQLPPRVLTQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEVQPRFFKVHILNDEHKTMAARAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATSRPKKAKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGNSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSARCPSQGTKGKVEDSALASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCLPGAEGQGVQKWIRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADFTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLNVKGIKEPVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKSDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPAMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQGPSLESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSSSTALPGPPAPLVDSSAVPGTALGTEPRHGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQESARRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTPPFTSQAGENSLFMGSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVTGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSVYPSYISPHTGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK", "length": 1468, "header": "tr|E1BEK4-1|E1BEK4_BOVIN Isoform 1 of Helicase ARIP4 OS=Bos taurus OX=9913 GN=RAD54L2 PE=3 SV=3 CANONICAL=E1BEK4-1" }, "isoforms": [ { "isoform_ac": "E1BEK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK4/entry#E1BEK4-1", "sequence": { "sequence": "MSDESASGSDPDLDPDVELEDAEEEEEEEEEVAVEEHGRDDGEDLLDDPSLEDMCGTECAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKGLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLELFPEEIVLRASDGPQLPPRVLTQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEVQPRFFKVHILNDEHKTMAARAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATSRPKKAKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGNSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSARCPSQGTKGKVEDSALASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCLPGAEGQGVQKWIRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADFTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLNVKGIKEPVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKSDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPAMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQGPSLESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSSSTALPGPPAPLVDSSAVPGTALGTEPRHGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQESARRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTPPFTSQAGENSLFMGSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVTGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSVYPSYISPHTGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK", "length": 1468, "header": "tr|E1BEK4-1|E1BEK4_BOVIN Isoform 1 of Helicase ARIP4 OS=Bos taurus OX=9913 GN=RAD54L2 PE=3 SV=3 CANONICAL=E1BEK4-1" }, "locus": { "chromosome": "22", "start_pos": 49217583, "end_pos": 49169590, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045730.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045730.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043096.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043096.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784245", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784245", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G3P6-1", "protein_name": "Helicase ARIP4", "gene_name": "Rad54l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDESASGSDPDLDPDEEEVAVEEHDRDDEEGLLDDPSLEGMCGTEHAQLGEDGQRPPRCTSTTSSQSEPSEQLRHQGKILASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKEYAAPIPTVPLEFLPEEIVLRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDALNQHDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEIQPRFFKVHILNDEHKTVASRAKVTTDWVSEGGVLLMGYEMYRLLTLKKSLATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSTRCPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCPPGAEGQGAQKWVRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLDIKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDDKPVASVRPVQSTPIPMMPRHVPLGGSVSSASNTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARISAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQGPSLASTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESHQNSPSISAALPGPPAQLMDNSTIPGTALGTEPCLGGHCLNSSLLVTGQPSSGRHPVLDLRGHKRKLATPSVSQESVRRRSRKGHLPAPVQPYEHGYPVSGGFSMPPVSLNHNLTTPFTSQAGENSLFMGSNPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSVYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK", "length": 1455 }, "evidence": [ { "id": "E1BEK4", "url": "https://omabrowser.org/oma/group/E1BEK4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M2BLB3-1", "protein_name": "Helicase ARIP4 isoform X1", "gene_name": "rad54l2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRSEWRCVSNALGDPGDAMSEEAISGSDLEPSLNSEEEEEEEEMDEEEEEDGENDGDDEEDAGDQLESLEMEDRRDPSSPAPTSPMSGDSSPERLSRPASRPSSTSRTSSRPGSQPPSSPDTRSNASANSNTKKKTSKTSKPAHLRRNIRKLLTENQLEAGTKAAQQEELERRRRLEQQRKEFSLHADLATAAAGSKQEVICLDSSGDEGEEKEAPPPPLPDHRDDVIELSSGDEGDALRISSEEEEDRSLTPGTEESSGSHINDSLNQPDSQGRVLININHPAEEEDLFLAPQLARAVKPHQIGGIRFLYDNLVESLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWLPAAEALPPDTDPQQVLPRTFKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRLLSLKKSFVTGRKRKSKKPAGPVIIDLDEEDRQQELMKAIERALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRRGHDVLRHQLPPKEEHVILVRLSRLQRALYTEFMNRFREAGNSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDLDDLNSSSGTRCSAPGIKSKTSDAANSRQMSVGHLNPLQEKANQVITYEWAKEVMTNYQTGVLENSAKMVLLFYLIDETVARGDKILVFSQSLSTLTVIEDFLSRRPMPIQTETGTHNWVRNINYYRLDGSTSASERERLINQFNDPANTQAWVFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQRKPCHIYRLVCDFTLEKKIYDRQVSKQGMSDRVVDDLNPVLNFTRKEVESLLHFVEEEPDPAELQPNNEMETVIQQACVMYPHLLTKPPFHHESLLMDRKEMKLTKAEKRAAKKSYEDEKRASVPYQRPSYAHYYPASDQRLTNIPAFSQRNWRPPPHLEEKPVASVRPVQSTPIPMMPRQVPMGVPSSSTGFPVNYLQKAGVYVQRVVTTTDIVIPGSNSSTDVQARIGAGESIHVIRGSKGTYIRTNDGRIFAIRSGKPRPPEGGATASREDCGPPLHSVSNGRASPQEPKRLTPEALPRPSSRESPRFHREFHSNKEAVASAENLTSSGTPESTGADRPIQHPSHLPEQHRQLSNDIASSVDVQSLKRKLLESRTSKQPGGKRTSTSTSAAGSYPGFPLNSGFGFPSMALNPALLGALGHVTPPSLGSRSHLMQQAGQTLGDLHAMFPTEPLGLGVSNSTLSSTCSTNTTSSSHSGMLASSSSSVPSSSLSSTSSSLPPFMMNPSMASMLSGFPVPFSQPLFPGSLHPRGLSSTSTPASTASSFLSSSSLLGTAFSRPDTHPSLTENGGSSSDDDVIEVMGQ", "length": 1455 }, "evidence": [ { "id": "E1BEK4", "url": "https://omabrowser.org/oma/group/E1BEK4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7GXE1-1", "protein_name": "Helicase ARIP4", "gene_name": "Rad54l2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDESASGSDPDLDPDVELEDAEEEEEEEEVAEEEHDRDDEEGLLDDPSLEGMCGTEHAQLGEDGQRPPRCTSTTSSQSEPSEQLRHQGKIQASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKEYAAPIPTVPLEFLPEEIVLRASDGPQLPPRVLAQEVICLDSSSGSEDEKCSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDALNQHDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPADSKPEEVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSSRCPPQGTKVKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDVPCLPGAEGQGAQKWVRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLDIKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASVTCILSPGSQGSSLASTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQNSPSISTALPGPPAQLMDSSTIPGTALGTEPCLGGHCLNSSLLVTGQPSGGRHPVLDLRGHKRKLATPSATQESVRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGDNSLFMGNTPSFYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPSYSLPFSQPLLSEPRMFAPFPSPMLPSNLSRGMSVYPGGYMSPHAGYPASGLLQSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK", "length": 1474 }, "evidence": [ { "id": "E1BEK4", "url": "https://omabrowser.org/oma/group/E1BEK4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9W1A8-1", "protein_name": "Helicase ARIP4", "gene_name": "Arip4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDNPEANMEESNPNYDVNQRLQKPEGWPHVNEFHPSMMYPDDPRRYFHNASTDPQHQPQQHPQQQPEQHPEQHPQHPLHSQQQPQQHPQQQPQQHPQQQTQQPPQLQPQQHPQAQIQPPIPVPISTPMEGTMEVPVKMPEYCPETSQPVEPDRVINPLAEVAKNTVPYGHKRKNSAGEDQAANKKLSMAAAEEKKNSHLRKNIRDVMNENNLDTTTLAAQREESERLARVAGQQKSMREIQKQVVHKQIFRILQLDESEGIESCAVANPVEHHPPVDFPEEEIASDTFDDSNSSSLSGGSIEDVLHKGASVQPSEVVTIDDSSDDDCILLSEEEEEEDDEDLNESDDATNSGMHVKDIYNVPDENGQVVVNMAHPEGEETLYLAPQIAKVIKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVRTKAFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERERLVNEFNANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQIKKQGMSDRIVDECNPEAHLSMKDITNLCQDYDSDEDTVEEVNKSTGDLSKPGSPSEEGSKPGSANMSPNASNKSNNGPTKPLDDQNTPKSPNGASHSPIKTEKNDGQEHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQAEKRQAHRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPMNQQIKTNTSSSTGGRSTRWIPADVWQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRVMVLKSAKGIYMQLDSGKIIAIRTTAKTEPEKTNKDDVIDITDDGDTDTTKPQSPEEDVKDLTADDEPRVVKNKESNPATTSRPEMPAKDRKSTENVQHFKSQTQPNTTLATTTNQHQLPSDLTYSQPQQSHQQPQQQASQQQPAQQPPPPAYKHQNHLPAAGEGYSNANSIQPNVPLPPHPGAPNSSEAPPPADSSYFQPKPFQHTYPPQYYDYYDNKHKSAPPGSGYHINNYTSYGNLNFAPYHSNLHPPASYIGAPSSYVNSNVFPRQHWSSVVNSSPASSESMRQPSYIGSTYPVNEWSSQ", "length": 1669 }, "evidence": [ { "id": "E1BEK4", "url": "https://omabrowser.org/oma/group/E1BEK4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y4B4-1", "protein_name": "Helicase ARIP4", "gene_name": "RAD54L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDESASGSDPDLDPDVELEDAEEEEEEEEVAVEECDRDDEEDLLDDPSLEGMCGTEHAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLEFLPEEIALRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEDDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPADNKPEEVQPRFFKVHILNDEHKTMASRAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKESLANEQDLDVEELGSAGTSARCPPQGTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQKWVRNISYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQVSLNVKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKVPEDGRMAASGSQGPSCESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNAALPGPPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQESSRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK", "length": 1467 }, "evidence": [ { "id": "E1BEK4", "url": "https://omabrowser.org/oma/group/E1BEK4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA/RNA helicase activity", "id": "GO:0033677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033677", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "ATP-dependent chromatin remodeler activity", "id": "GO:0140658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140658", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" }, { "name": "R-loop processing", "id": "GO:0062176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062176", "evidence": [ { "database": "UniProtKB", "id": "E1BEK4", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1084, "end_pos": 1086, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1233, "end_pos": 1235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1305, "end_pos": 1307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1409, "end_pos": 1411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 780, "end_pos": 782, "annotation": "n_glycosylation_sequon" }, { "start_pos": 807, "end_pos": 809, "annotation": "n_glycosylation_sequon" }, { "start_pos": 898, "end_pos": 900, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 293, "end_pos": 513, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK4" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 729, "end_pos": 897, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1084, "end_pos": 1086 }, { "start_pos": 1233, "end_pos": 1235 }, { "start_pos": 1305, "end_pos": 1307 }, { "start_pos": 1409, "end_pos": 1411 }, { "start_pos": 780, "end_pos": 782 }, { "start_pos": 807, "end_pos": 809 }, { "start_pos": 898, "end_pos": 900 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEK8-1", "uniprot_ac": "E1BEK8", "uniprot_id": "E1BEK8_BOVIN", "mass": { "chemical_mass": 35851.0, "monoisotopic_mass": 35851.0 }, "refseq": {}, "gene_names": [ { "name": "LOC618581", "type": "recommended", "evidence": [ { "id": "E1BEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" } ] } ], "protein_names": [ { "name": "Fibrinogen C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEK8", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC618581", "url": "https://www.uniprot.org/uniprotkb/E1BEK8", "locus": {} } ], "crossref": [ { "id": "E1BEK8", "url": "https://alphafold.ebi.ac.uk/entry/E1BEK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048662", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048662", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NYVASSC", "url": "https://omabrowser.org/oma/group/NYVASSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEK8", "url": "https://www.orthodb.org/?gene=E1BEK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16146:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16146:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1BEK8", "url": "https://www.uniprot.org/uniprotkb/E1BEK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEK8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAQGTGVRFYFLLFLTVATRGQSAAGTLAVEKFWEEETCAPYLSFLPRSCKEIKERCHKAADGLYHLRTENGVVYQTFCDMTSGGGGWTLVASIHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAQDLGIWHVPNKSPLQHWRNSSLLRYHTNSGFFCRLGHNLFGLYLKYPVKYGAGNCWSDNGPAIPVEYDFGDAEKAASYYSPNGQREFVAGFVQFRVFNNERAAHALCAGMRVTGCNTEHHCIGGGGFFPEGDPVQCGDFSSFDWDGYGTHRGSSSSREITEAAVLLFYC", "length": 323, "header": "tr|E1BEK8-1|E1BEK8_BOVIN Isoform 1 of Fibrinogen C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC618581 PE=4 SV=3 CANONICAL=E1BEK8-1" }, "isoforms": [ { "isoform_ac": "E1BEK8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEK8/entry#E1BEK8-1", "sequence": { "sequence": "MPAQGTGVRFYFLLFLTVATRGQSAAGTLAVEKFWEEETCAPYLSFLPRSCKEIKERCHKAADGLYHLRTENGVVYQTFCDMTSGGGGWTLVASIHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAQDLGIWHVPNKSPLQHWRNSSLLRYHTNSGFFCRLGHNLFGLYLKYPVKYGAGNCWSDNGPAIPVEYDFGDAEKAASYYSPNGQREFVAGFVQFRVFNNERAAHALCAGMRVTGCNTEHHCIGGGGFFPEGDPVQCGDFSSFDWDGYGTHRGSSSSREITEAAVLLFYC", "length": 323, "header": "tr|E1BEK8-1|E1BEK8_BOVIN Isoform 1 of Fibrinogen C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC618581 PE=4 SV=3 CANONICAL=E1BEK8-1" }, "locus": { "chromosome": "3", "start_pos": 8602090, "end_pos": 8591984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040050.5", "url": "https://www.ensembl.org/id/ENSBTAT00000040050.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039833.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039833.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E9PT30-1", "protein_name": "Intelectin 1", "gene_name": "Itln1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFFLNCGYIIYIPEHIKTSVPTEMMPLRCRLGAYYLLKKLACGAKEDPETNKGTHSFFDSLFRSCKEIKEENTRAQDGLYFLRTENGVIYQTFCDMTTAGGGWTLVASVHENNMGGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEGATSDDYKNPGYFDIQAENLGIWHVPNNSPLHNWRNSSLLRYRTFTGFLQHLGHNLFGLYQKYPVKYGVGKCWTDNGPALPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVYNNERAASALCAGVRVTGCNSEAHCIGGGGFFPEGNPRQCGDFGAFDWNGYGTHTGYSSSRAITEAAVLLFYR", "length": 338 }, "evidence": [ { "id": "E1BEK8", "url": "https://omabrowser.org/oma/group/E1BEK8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WWU7-1", "protein_name": "Intelectin-2", "gene_name": "ITLN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSMLRTMTRLCFLLFFSVATSGCSAAAASSLEMLSREFETCAFSFSSLPRSCKEIKERCHSAGDGLYFLRTKNGVVYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGNKADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSALLRYRTNTGFLQRLGHNLFGIYQKYPVKYRSGKCWNDNGPAIPVVYDFGDAKKTASYYSPYGQREFVAGFVQFRVFNNERAANALCAGIKVTGCNTEHHCIGGGGFFPQGKPRQCGDFSAFDWDGYGTHVKSSCSREITEAAVLLFYR", "length": 325 }, "evidence": [ { "id": "E1BEK8", "url": "https://omabrowser.org/oma/group/E1BEK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oligosaccharide binding", "id": "GO:0070492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070492", "evidence": [ { "database": "UniProtKB", "id": "E1BEK8", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BEK8", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BEK8", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEK8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEK8" }, { "id": "PS51406", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 92, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 173, "end_pos": 175 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEL8-1", "uniprot_ac": "E1BEL8", "uniprot_id": "E1BEL8_BOVIN", "mass": { "chemical_mass": 16071.0, "monoisotopic_mass": 16071.0 }, "refseq": { "ac": "NP_001103977", "name": "hemoglobin, epsilon 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977" }, "gene_names": [ { "name": "HBE1", "type": "recommended", "evidence": [ { "id": "E1BEL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ] }, { "name": "GLNB1", "type": "synonym", "evidence": [ { "id": "NP_001103977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977" } ] }, { "name": "HBE1", "type": "synonym", "evidence": [ { "id": "NP_001103977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977" } ] } ], "protein_names": [ { "name": "Hemoglobin, epsilon 1", "type": "synonym", "evidence": [ { "id": "E1BEL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL8/entry#names_and_taxonomy" } ] }, { "name": "globin B1", "type": "synonym", "evidence": [ { "id": "NP_001103977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977" } ] }, { "name": "hemoglobin, epsilon 1", "type": "synonym", "evidence": [ { "id": "NP_001103977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HBE1", "url": "https://www.uniprot.org/uniprotkb/E1BEL8", "locus": { "chromosome": "15", "start_pos": 48338849, "end_pos": 48337002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039056", "url": "https://www.ensembl.org/id/ENSBTAG00000039056" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037815", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037815", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08925", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08925", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539994", "url": "https://www.ncbi.nlm.nih.gov/gene/539994", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539994", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539994", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICGNPQV", "url": "https://omabrowser.org/oma/group/ICGNPQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEL8", "url": "https://www.orthodb.org/?gene=E1BEL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001103977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEL8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHFTAEEKAAITGLWGKVNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSFGEAIKNLDNLKGAFAKLSELHCDKLHVDPENFRLLGNVIVIILATHFGREFTPDVQAAWQKLVSGVATALAHKYH", "length": 147, "header": "tr|E1BEL8-1|E1BEL8_BOVIN Isoform 1 of Hemoglobin, epsilon 1 OS=Bos taurus OX=9913 GN=HBE1 PE=3 SV=1 CANONICAL=E1BEL8-1" }, "isoforms": [ { "isoform_ac": "E1BEL8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEL8/entry#E1BEL8-1", "sequence": { "sequence": "MVHFTAEEKAAITGLWGKVNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSFGEAIKNLDNLKGAFAKLSELHCDKLHVDPENFRLLGNVIVIILATHFGREFTPDVQAAWQKLVSGVATALAHKYH", "length": 147, "header": "tr|E1BEL8-1|E1BEL8_BOVIN Isoform 1 of Hemoglobin, epsilon 1 OS=Bos taurus OX=9913 GN=HBE1 PE=3 SV=1 CANONICAL=E1BEL8-1" }, "locus": { "chromosome": "15", "start_pos": 48338729, "end_pos": 48337082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045696.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045696.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043065.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043065.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539994", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539994", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RII6-1", "protein_name": "Hemoglobin subunit epsilon 1", "gene_name": "HBE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVHFTAEEKSVITGLWGKVNVEETGGEAVGRLLVVYPWTQRFFDSFGNMSSPSAIMGNPKVKAHGKKVLTSFGDAVKNMDNLKGTFAKLSELHCDKLHVDPENFRLLGNMIVIILASHFGGEFTPEVQAAWQKLVAGVATALAHKYH", "length": 147 }, "evidence": [ { "id": "E1BEL8", "url": "https://omabrowser.org/oma/group/E1BEL8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P02100-1", "protein_name": "Hemoglobin subunit epsilon", "gene_name": "HBE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH", "length": 147 }, "evidence": [ { "id": "E1BEL8", "url": "https://omabrowser.org/oma/group/E1BEL8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P02112-1", "protein_name": "Hemoglobin subunit beta", "gene_name": "HBB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVHWTAEEKQLITGLWGKVNVAECGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFSKDFTPECQAAWQKLVRVVAHALARKYH", "length": 147 }, "evidence": [ { "id": "E1BEL8", "url": "https://omabrowser.org/oma/group/E1BEL8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P04246-1", "protein_name": "Hemoglobin subunit theta", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "VHFTAEEKSVITGLWGKVNVEETGGEAVGRLLVVYPWTQRFFDSFGNMSSPSAIMGNPKVKAHGKKVLTSFGDAVKNMDNLKGTFAKLSELHCDKLHVDPENFRLLGNMIVIILASHFGGEFTPEVQAAWQKLVAGVATALAHKYH", "length": 146 }, "evidence": [ { "id": "E1BEL8", "url": "https://omabrowser.org/oma/group/E1BEL8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "E1BEL8", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL8" }, { "id": "PS01033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 147, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEM3-1", "uniprot_ac": "E1BEM3", "uniprot_id": "E1BEM3_BOVIN", "mass": { "chemical_mass": 27532.0, "monoisotopic_mass": 27532.0 }, "refseq": { "ac": "NP_001178969", "name": "protein CDV3 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178969" }, "gene_names": [ { "name": "CDV3", "type": "recommended", "evidence": [ { "id": "E1BEM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM3" } ] }, { "name": "CDV3", "type": "synonym", "evidence": [ { "id": "NP_001178969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178969" } ] } ], "protein_names": [ { "name": "CDV3 homolog", "type": "synonym", "evidence": [ { "id": "E1BEM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM3/entry#names_and_taxonomy" } ] }, { "name": "protein CDV3 homolog", "type": "synonym", "evidence": [ { "id": "NP_001178969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178969" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEM3", "url": "https://www.uniprot.org/uniprotkb/E1BEM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDV3", "url": "https://www.uniprot.org/uniprotkb/E1BEM3", "locus": { "chromosome": "1", "start_pos": 135867529, "end_pos": 135881717, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035556", "url": "https://www.ensembl.org/id/ENSBTAG00000035556" } ] } } ], "crossref": [ { "id": "E1BEM3", "url": "https://alphafold.ebi.ac.uk/entry/E1BEM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035556", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035556", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504871", "url": "https://www.ncbi.nlm.nih.gov/gene/504871", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504871", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504871", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSGPWNK", "url": "https://omabrowser.org/oma/group/TSGPWNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEM3", "url": "https://www.orthodb.org/?gene=E1BEM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16284", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16284", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16284:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16284:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15359", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15359", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178969", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEM3", "url": "https://www.uniprot.org/uniprotkb/E1BEM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAETEERSLDNFFAKRDKKKKKERSNRAASAASAAGGAGGSSGATGAAGGGAGAGTRPGDSGTAGVGATGPGAATKVVTKEEDEWKEFEQKEVDYSGLRVQAMQISSEKEEDEVEKREDPSDNWEEGGGGGGGVEKSSGPWNKTAPVQAPPAPVVVTETPEPTMTSGVYRPPGARLTTTRKAPQGPPEIYSDTQFPSLQSTAKHVESRKDKEMEKSFEVVRHKTRGRDEFSKNQALKLQLDNQYAVLENQKSSHTQYN", "length": 258, "header": "tr|E1BEM3-1|E1BEM3_BOVIN Isoform 1 of CDV3 homolog OS=Bos taurus OX=9913 GN=CDV3 PE=1 SV=3 CANONICAL=E1BEM3-1" }, "isoforms": [ { "isoform_ac": "E1BEM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM3/entry#E1BEM3-1", "sequence": { "sequence": "MAETEERSLDNFFAKRDKKKKKERSNRAASAASAAGGAGGSSGATGAAGGGAGAGTRPGDSGTAGVGATGPGAATKVVTKEEDEWKEFEQKEVDYSGLRVQAMQISSEKEEDEVEKREDPSDNWEEGGGGGGGVEKSSGPWNKTAPVQAPPAPVVVTETPEPTMTSGVYRPPGARLTTTRKAPQGPPEIYSDTQFPSLQSTAKHVESRKDKEMEKSFEVVRHKTRGRDEFSKNQALKLQLDNQYAVLENQKSSHTQYN", "length": 258, "header": "tr|E1BEM3-1|E1BEM3_BOVIN Isoform 1 of CDV3 homolog OS=Bos taurus OX=9913 GN=CDV3 PE=1 SV=3 CANONICAL=E1BEM3-1" }, "locus": { "chromosome": "1", "start_pos": 135881384, "end_pos": 135869786, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023484.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023484.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504871", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504871", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7T370-1", "protein_name": "Protein CDV3 homolog", "gene_name": "cdv3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADVAPAGVEKSLDDFFAKRDKKKKKEKGKGKEQVTGAAAAAAMPVKKMKKEKEKSTKSENQDAQMEKEDEEWKEFEQKEVDYTGLRLQAMQMSDEKEEEEYEKEEVGEDGEIILVTSDKMSGPWNKSGGAPPSAASAPVEEVEVPEPKAPGVYRPPGARLTTTKKAPAQGPPEIFSDAQFPSLLSTARHVETRKDREMEKTFEVVKHKSRVREGEGPGSMQQLQLDNQYAILGDK", "length": 236 }, "evidence": [ { "id": "E1BEM3", "url": "https://omabrowser.org/oma/group/E1BEM3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9UKY7-1", "protein_name": "Protein CDV3 homolog", "gene_name": "CDV3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAETEERSLDNFFAKRDKKKKKERSNRAASAAGAAGSAGGSSGAAGAAGGGAGAGTRPGDGGTASAGAAGPGAATKAVTKDEDEWKELEQKEVDYSGLRVQAMQISSEKEEDDNEKRQDPGDNWEEGGGGGGGMEKSSGPWNKTAPVQAPPAPVIVTETPEPAMTSGVYRPPGARLTTTRKTPQGPPEIYSDTQFPSLQSTAKHVESRKDKEMEKSFEVVRHKNRGRDEVSKNQALKLQLDNQYAVLENQKSSHSQYN", "length": 258 }, "evidence": [ { "id": "E1BEM3", "url": "https://omabrowser.org/oma/group/E1BEM3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BEM3", "url": "https://www.uniprot.org/uniprotkb/E1BEM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEM3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEM4-1", "uniprot_ac": "E1BEM4", "uniprot_id": "E1BEM4_BOVIN", "mass": { "chemical_mass": 13868.0, "monoisotopic_mass": 13868.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Proliferation-inducing protein 13", "type": "recommended", "evidence": [ { "id": "E1BEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEM4", "url": "https://www.uniprot.org/uniprotkb/E1BEM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BEM4", "locus": {} } ], "crossref": [ { "id": "E1BEM4", "url": "https://alphafold.ebi.ac.uk/entry/E1BEM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017660", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017660", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KECICCL", "url": "https://omabrowser.org/oma/group/KECICCL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14974", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14974", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14974:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14974:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BEM4", "url": "https://www.uniprot.org/uniprotkb/E1BEM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCASTKHVATVQNEEEAQKGKNYQNGDVFGDEYRIKPVEEVKYMKNGAEEEQKIAARNQENLGKSASSNVRLKTNKEISGLVHQPRANMHISESQQEFFRMLDEKIEKGRDYCSEEEGIT", "length": 121, "header": "tr|E1BEM4-1|E1BEM4_BOVIN Isoform 1 of Proliferation-inducing protein 13 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=E1BEM4-1" }, "isoforms": [ { "isoform_ac": "E1BEM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM4/entry#E1BEM4-1", "sequence": { "sequence": "MRCASTKHVATVQNEEEAQKGKNYQNGDVFGDEYRIKPVEEVKYMKNGAEEEQKIAARNQENLGKSASSNVRLKTNKEISGLVHQPRANMHISESQQEFFRMLDEKIEKGRDYCSEEEGIT", "length": 121, "header": "tr|E1BEM4-1|E1BEM4_BOVIN Isoform 1 of Proliferation-inducing protein 13 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=E1BEM4-1" }, "locus": { "chromosome": "X", "start_pos": 86325591, "end_pos": 86325229, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023483.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023483.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023483.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023483.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 121, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEM4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEM8-1", "uniprot_ac": "E1BEM8", "uniprot_id": "E1BEM8_BOVIN", "mass": { "chemical_mass": 15933.0, "monoisotopic_mass": 15933.0 }, "refseq": { "ac": "NP_001193629", "name": "grifin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193629" }, "gene_names": [ { "name": "GRIFIN", "type": "recommended", "evidence": [ { "id": "E1BEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" } ] }, { "name": "GRIFIN", "type": "synonym", "evidence": [ { "id": "NP_001193629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193629" } ] } ], "protein_names": [ { "name": "Galectin", "type": "recommended", "evidence": [ { "id": "E1BEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM8/entry#names_and_taxonomy" } ] }, { "name": "grifin", "type": "synonym", "evidence": [ { "id": "NP_001193629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193629" } ] } ], "function": [ { "annotation": "Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8#function" }, { "database": "UniProtKB", "id": "ARBA00059180", "url": "https://www.uniprot.org/uniprotkb/ARBA00059180#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRIFIN", "url": "https://www.uniprot.org/uniprotkb/E1BEM8", "locus": { "chromosome": "25", "start_pos": 40801701, "end_pos": 40800339, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020896", "url": "https://www.ensembl.org/id/ENSBTAG00000020896" } ] } } ], "crossref": [ { "id": "E1BEM8", "url": "https://alphafold.ebi.ac.uk/entry/E1BEM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020896", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020896", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00070", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00070", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528362", "url": "https://www.ncbi.nlm.nih.gov/gene/528362", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528362", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528362", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GICPGWS", "url": "https://omabrowser.org/oma/group/GICPGWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEM8", "url": "https://www.orthodb.org/?gene=E1BEM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193629", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALQFEAFHAGGLAPGWNLLVQGHSDSGEDQFEINFLSETGDIVFHIKPRFSSATMVANAFQGGRWGQEEASSIFPLVLGEPFEMEVSSDAEHFHVHAQEHKVLQFAHRHRPLAAITRVQVLSDHRLAQVELARKGLSWGAGGY", "length": 144, "header": "tr|E1BEM8-1|E1BEM8_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=GRIFIN PE=4 SV=3 CANONICAL=E1BEM8-1" }, "isoforms": [ { "isoform_ac": "E1BEM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEM8/entry#E1BEM8-1", "sequence": { "sequence": "MALQFEAFHAGGLAPGWNLLVQGHSDSGEDQFEINFLSETGDIVFHIKPRFSSATMVANAFQGGRWGQEEASSIFPLVLGEPFEMEVSSDAEHFHVHAQEHKVLQFAHRHRPLAAITRVQVLSDHRLAQVELARKGLSWGAGGY", "length": 144, "header": "tr|E1BEM8-1|E1BEM8_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=GRIFIN PE=4 SV=3 CANONICAL=E1BEM8-1" }, "locus": { "chromosome": "25", "start_pos": 40801550, "end_pos": 40800344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027839.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027839.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027839.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027839.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528362", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528362", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A4D1Z8-1", "protein_name": "Grifin", "gene_name": "GRIFIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVQSKAFCAGGLAPGWKLLVQGHADSGEDRFETNFLLETGDIAFHIKPRFSSATVVGNAFQYGRWGPEQVSSIFPLAPGEPFEIEVSWDAEHFHVYAPEHKVLQFPCRQRPLGATTRVRVLSDHCLAQVELAKRGLSWGDRGY", "length": 144 }, "evidence": [ { "id": "E1BEM8", "url": "https://omabrowser.org/oma/group/E1BEM8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1RI61-1", "protein_name": "Galectin", "gene_name": "GRIFIN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALQFEAFYAGGLAPGWNLLVQGHSDSGEDKFEINFLSEAGDIVFHIKPRFSSASIVANTFQGGRWGQEEVSTVFPLVLGEPFEMEVSSDAEHFHVHAQEHKVLQFAHRHRPLAAITRVQVLSDHRLAQVELARRGLSWGEGGY", "length": 144 }, "evidence": [ { "id": "E1BEM8", "url": "https://omabrowser.org/oma/group/E1BEM8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O88644-1", "protein_name": "Grifin", "gene_name": "Grifin", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALQFEAFCAGGLAPGWSLTVQGHADAGEDKFEINFLTDAGDIAFHVKPRFSSATVVGNAFQGGRWGQEEVSSVFPLTLGEPFEVEVSADTEHFHIYAQEQKVLQFPHRHRPLATITRVRVLSDHQLAQVELAKRGLSWGDGGY", "length": 144 }, "evidence": [ { "id": "E1BEM8", "url": "https://omabrowser.org/oma/group/E1BEM8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DGJ1-1", "protein_name": "Grifin", "gene_name": "grifin", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTLRFEASCPDGLCPGWSVILKGETPPEASKFEINFLCDRDDRVAFHFNPRFTESDIICNSYMANRWGQEERCNHFPLGVEEPFQIEIYSDNDHFHVYIDKAKVMQYKHRVEDLKTITKLQVVNDVKISSLEITKKLFY", "length": 139 }, "evidence": [ { "id": "E1BEM8", "url": "https://omabrowser.org/oma/group/E1BEM8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D1U0-1", "protein_name": "Grifin", "gene_name": "Grifin", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLQFEAFCAGGLAPGWSLTVQGHADAGEEKFEINFLTDAGDIAFHVKPRFSSATVVGNAFQGGRWGQEEVSSIFPLTLGEPFEMEVSADAEHFHIYAQEQKVLQFPHRHRPLATITRVRVLSEHRLAQVELAKRSLSWGDGGY", "length": 144 }, "evidence": [ { "id": "E1BEM8", "url": "https://omabrowser.org/oma/group/E1BEM8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BEM8", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEM8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEM8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEM8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEM8" }, { "id": "PS51304", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51304" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galectin", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 133, "start_aa": "Phe", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEQ6-1", "uniprot_ac": "E1BEQ6", "uniprot_id": "E1BEQ6_BOVIN", "mass": { "chemical_mass": 21486.0, "monoisotopic_mass": 21486.0 }, "refseq": { "ac": "XP_002689698", "name": "uncharacterized protein C9orf40 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689698" }, "gene_names": [ { "name": "C8H9orf40", "type": "recommended", "evidence": [ { "id": "E1BEQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6" } ] }, { "name": "C8H9orf40", "type": "synonym", "evidence": [ { "id": "XP_002689698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689698" } ] } ], "protein_names": [ { "name": "Chromosome 8 C9orf40 homolog", "type": "synonym", "evidence": [ { "id": "E1BEQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C9orf40 homolog", "type": "synonym", "evidence": [ { "id": "XP_002689698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689698" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEQ6", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C8H9orf40", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6", "locus": { "chromosome": "8", "start_pos": 51044459, "end_pos": 51050753, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013231", "url": "https://www.ensembl.org/id/ENSBTAG00000013231" } ] } } ], "crossref": [ { "id": "E1BEQ6", "url": "https://alphafold.ebi.ac.uk/entry/E1BEQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013231", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013231", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533577", "url": "https://www.ncbi.nlm.nih.gov/gene/533577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR042349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QLNEEFW", "url": "https://omabrowser.org/oma/group/QLNEEFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEQ6", "url": "https://www.orthodb.org/?gene=E1BEQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16003:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16003:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002689698", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689698", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEQ6", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKRRAAEPLTFHVPWKRLLLCDFPEEPPPPPLWIPPPGASYPGRPLGFPELPRKRKIDAGAMTEPSVSPSKRRDDGDTGAQGGAEREGRGLETGESQLLQPPVRPRGPGVEPRGVRPPRGGGDDGAGRAQPQRGDWGAAPRQLSEEFWQYNTFQYWRNPLPPIDLADIEDVSEDNLIETALQGKNEVAEIDMES", "length": 195, "header": "tr|E1BEQ6-1|E1BEQ6_BOVIN Isoform 1 of Chromosome 8 C9orf40 homolog OS=Bos taurus OX=9913 GN=C8H9orf40 PE=4 SV=1 CANONICAL=E1BEQ6-1" }, "isoforms": [ { "isoform_ac": "E1BEQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEQ6/entry#E1BEQ6-1", "sequence": { "sequence": "MAKRRAAEPLTFHVPWKRLLLCDFPEEPPPPPLWIPPPGASYPGRPLGFPELPRKRKIDAGAMTEPSVSPSKRRDDGDTGAQGGAEREGRGLETGESQLLQPPVRPRGPGVEPRGVRPPRGGGDDGAGRAQPQRGDWGAAPRQLSEEFWQYNTFQYWRNPLPPIDLADIEDVSEDNLIETALQGKNEVAEIDMES", "length": 195, "header": "tr|E1BEQ6-1|E1BEQ6_BOVIN Isoform 1 of Chromosome 8 C9orf40 homolog OS=Bos taurus OX=9913 GN=C8H9orf40 PE=4 SV=1 CANONICAL=E1BEQ6-1" }, "locus": { "chromosome": "8", "start_pos": 51050554, "end_pos": 51044479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017603.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017603.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017603.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017603.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533577", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q66H24-1", "protein_name": "Uncharacterized protein C9orf40 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKRRAAEPLTFRVPWKRLLLSDFPEEPPLWVPPSGAARPLKRQGDAGTMAEPASAPRKRRGGGDDEPELQGRGLEPGEPPPGEQGEPQVSRAAGGGDRVESAGSPQGADEVHSQHNEDFWQYNTFQYWRNPLPPIDLAALEDVSANSLTETLEDKNEGVEIDMES", "length": 166 }, "evidence": [ { "id": "E1BEQ6", "url": "https://omabrowser.org/oma/group/E1BEQ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IXQ3-1", "protein_name": "Uncharacterized protein C9orf40", "gene_name": "C9orf40", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKRRAAEPVTFHVPWKRLLLCDFAEQPPPPPLWIRPPGVAHAGQLLGVPEQHRKRKIDAGTMAEPSASPSKRRDSGDNSAPSGQEREDHGLETGDPPLPPPPVLPGPGEELPGARLPGGGGDDGAGRAGPPRGDWGVASRQHNEEFWQYNTFQYWRNPLPPIDLADIEDLSEDTLTEATLQGRNEGAEVDMES", "length": 194 }, "evidence": [ { "id": "E1BEQ6", "url": "https://omabrowser.org/oma/group/E1BEQ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCE4-1", "protein_name": "Uncharacterized protein C9orf40 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKRRAAEPLTFRVPWKRLLLSDFPEEPPLWVPPSGTARPLKRQGDAGIMAEPASAPRKRRGGGDDRQELQGCSREPGEPPPGEQEEPRAAGGGDRVESAGSPQVADGVHSQQPEEFWQYNTFQYWRNPLPPLDLAALEDVSANSLTETLEDKNEGVEIDMES", "length": 163 }, "evidence": [ { "id": "E1BEQ6", "url": "https://omabrowser.org/oma/group/E1BEQ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEQ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 195, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEQ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEQ6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BER1-1", "uniprot_ac": "E1BER1", "uniprot_id": "E1BER1_BOVIN", "mass": { "chemical_mass": 34884.0, "monoisotopic_mass": 34884.0 }, "refseq": { "ac": "NP_001376969", "name": "olfactory receptor 10G6", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376969" }, "gene_names": [ { "name": "OR10G6", "type": "recommended", "evidence": [ { "id": "E1BER1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ] }, { "name": "OR10G6", "type": "synonym", "evidence": [ { "id": "NP_001376969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376969" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily G member 6", "type": "synonym", "evidence": [ { "id": "E1BER1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER1/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10G6", "type": "synonym", "evidence": [ { "id": "NP_001376969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376969" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376969" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10G6", "url": "https://www.uniprot.org/uniprotkb/E1BER1", "locus": { "chromosome": "29", "start_pos": 26634718, "end_pos": 26635653, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033508", "url": "https://www.ensembl.org/id/ENSBTAG00000033508" } ] } } ], "crossref": [ { "id": "E1BER1", "url": "https://alphafold.ebi.ac.uk/entry/E1BER1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033508", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033508", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15942", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15942", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522385", "url": "https://www.ncbi.nlm.nih.gov/gene/522385", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522385", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522385", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTISCAI", "url": "https://omabrowser.org/oma/group/MTISCAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BER1", "url": "https://www.orthodb.org/?gene=E1BER1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376969", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BER1-1", "url": "https://www.uniprot.org/uniprotkb/E1BER1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRGNHTSVSHFILVGLHHPPQLGTPLFLTFLVIYTLTISGNGLIILTVLVDTQLHRPMYWFLCHLSLLDMTISSAIVPKMLAGFLLDSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTRSVCNYLAFGTWLGGILHSLFQTSFIFRLPFCGPNQVDYFFCDIPAMLRLACADTTINELTTLVDIGFLALTCFVLILTSYGYIVAAILRIRSADGRRNAFATCAAHLTVVIVYYVPCTFIYLRPGSQEPLDGVVAVFYTAITPLLNPIIYTLRNKEMKVALRRLGGRKVVKPH", "length": 311, "header": "tr|E1BER1-1|E1BER1_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily G member 6 OS=Bos taurus OX=9913 GN=OR10G6 PE=3 SV=3 CANONICAL=E1BER1-1" }, "isoforms": [ { "isoform_ac": "E1BER1-1", "url": "https://www.uniprot.org/uniprotkb/E1BER1/entry#E1BER1-1", "sequence": { "sequence": "MQRGNHTSVSHFILVGLHHPPQLGTPLFLTFLVIYTLTISGNGLIILTVLVDTQLHRPMYWFLCHLSLLDMTISSAIVPKMLAGFLLDSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTRSVCNYLAFGTWLGGILHSLFQTSFIFRLPFCGPNQVDYFFCDIPAMLRLACADTTINELTTLVDIGFLALTCFVLILTSYGYIVAAILRIRSADGRRNAFATCAAHLTVVIVYYVPCTFIYLRPGSQEPLDGVVAVFYTAITPLLNPIIYTLRNKEMKVALRRLGGRKVVKPH", "length": 311, "header": "tr|E1BER1-1|E1BER1_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily G member 6 OS=Bos taurus OX=9913 GN=OR10G6 PE=3 SV=3 CANONICAL=E1BER1-1" }, "locus": { "chromosome": "29", "start_pos": 26635653, "end_pos": 26634721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055059.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055059.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048773.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048773.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522385", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522385", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZWN1-1", "protein_name": "Olfactory receptor family 10 subfamily G member 6", "gene_name": "Or10g6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQSSNQTSVSHFILVGLHHPPQLGIPLFLAFLVIYLLTVSGNGLIILTVLVDVRLHRPMYWFLCHLSFLDLTISSAIVPKMLAGFLLDSRIISFGGCVVQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYAAIMTRSVCNYLALGTWIGGTIHSLFQTSFIFRLPFCGPNRVDYFFCDIPAVLCLVCADTTINELVTFVDIGFLALTCFVLILTSYGYIVAAILRIRSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPGSQEPLDGVVAVFYTVITPLLNPIIYTLRNKEMKAALQRLGGLREGQPC", "length": 311 }, "evidence": [ { "id": "E1BER1", "url": "https://omabrowser.org/oma/group/E1BER1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IIK4-1", "protein_name": "Olfactory receptor 10G6", "gene_name": "LOC100759783", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQSGNQTSVSHFILVGLHHPPQLGVPLFLAFLVIYLLTVSGNGLIILTVLVDIRLHRPMYWFLCHLSFLDMTISSAIVPKMLAGFLLDSRVISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTRSICNCLALGTWVGGTIHSLFQTSFLFRLPFCGPNRVDYFFCDIPAILSLVCADTTINELVTFVDIGFLALTCFMLILTSYGYIVAAILRIRSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPGSQEPLDGVVAVFYTVITPLLNPIIYTLRNKEMKAALRRLGGLKEVQPC", "length": 311 }, "evidence": [ { "id": "E1BER1", "url": "https://omabrowser.org/oma/group/E1BER1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8NH81-1", "protein_name": "Olfactory receptor 10G6", "gene_name": "OR10G6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLEGVEHLLLLLLLTDVNSKELQSGNQTSVSHFILVGLHHPPQLGAPLFLAFLVIYLLTVSGNGLIILTVLVDIRLHRPMCLFLCHLSFLDMTISCAIVPKMLAGFLLGSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTHRVCNSLALGTWLGGTIHSLFQTSFVFRLPFCGPNRVDYIFCDIPAMLRLACADTAINELVTFADIGFLALTCFMLILTSYGYIVAAILRIPSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPCSQEPLDGVVAVFYTVITPLLNSIIYTLCNKEMKAALQRLGGHKEVQPH", "length": 332 }, "evidence": [ { "id": "E1BER1", "url": "https://omabrowser.org/oma/group/E1BER1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VEU2-1", "protein_name": "Olfactory receptor family 10 subfamily G member 6", "gene_name": "Or10g6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSGNQTSVSHFILVGLHHPPQLGVPLFLAFLVIYLLTVSGNGLIILTVLVDIRLHRPMYWFLCHLSFLDLTISSAIVPKMLSGFLLDSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTRSVCNYLALGTWIGGTIHSLFQTSFIFRLPFCGPNRVDYFFCDIPAVLRLVCADTTINELVTFVDIGFLALTCFMLILTSYGYIVAAILRIRSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPGSQEPLDGVVAVFYTVITPLLNPIIYTLRNKQMKAALRRLGGLREVHP", "length": 310 }, "evidence": [ { "id": "E1BER1", "url": "https://omabrowser.org/oma/group/E1BER1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BER1", "url": "https://www.uniprot.org/uniprotkb/E1BER1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BER1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BER1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BER1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BER1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BER4-1", "uniprot_ac": "E1BER4", "uniprot_id": "E1BER4_BOVIN", "mass": { "chemical_mass": 82107.0, "monoisotopic_mass": 82107.0 }, "refseq": { "ac": "XP_002687937", "name": "EF-hand calcium-binding domain-containing protein 4B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687937" }, "gene_names": [ { "name": "CRACR2A", "type": "recommended", "evidence": [ { "id": "E1BER4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ] }, { "name": "CRACR2A", "type": "synonym", "evidence": [ { "id": "XP_002687937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687937" } ] } ], "protein_names": [ { "name": "Calcium release activated channel regulator 2A", "type": "synonym", "evidence": [ { "id": "E1BER4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER4/entry#names_and_taxonomy" } ] }, { "name": "EF-hand calcium-binding domain-containing protein 4B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687937" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRACR2A", "url": "https://www.uniprot.org/uniprotkb/E1BER4", "locus": { "chromosome": "5", "start_pos": 106299767, "end_pos": 106146767, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018940", "url": "https://www.ensembl.org/id/ENSBTAG00000018940" } ] } } ], "crossref": [ { "id": "E1BER4", "url": "https://alphafold.ebi.ac.uk/entry/E1BER4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018940", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018940", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00154", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00154", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525377", "url": "https://www.ncbi.nlm.nih.gov/gene/525377", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525377", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525377", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QERYRCV", "url": "https://omabrowser.org/oma/group/QERYRCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BER4", "url": "https://www.orthodb.org/?gene=E1BER4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687937", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687937", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BER4-1", "url": "https://www.uniprot.org/uniprotkb/E1BER4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATIDGRMVSRPRGSGRGRQGSGACLGSLDDLPCEGTQELAATQLAMLRRAQEFFQTCDKEGKGFIARADMQRLHKELPLSLEDLEDVFDTLDADGNGFLTPEEFTTGFSHFFFSQNNPSQEDAGAQPAQLQEEKVYQSRGDEDLGDMDEDEEAQFQTLMDRLGAQKVLEDEADVKQLWLQLKKDEPHLLSNFEDFLTRIFSQLLEAHEEKNELECALKKKIAAYDEEIQHLYEEMEQQIKTEKEQFLLKDTERFRARSQELERKLLSKEQELEQLVQKQKRLEGQCTALHNDKHETKAENTKLRLTNQELARELERTSRELQDAQQQLESLRQEAHKLHQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDEQDIRFQKDKAARANTAAPTARWKQRSGSVIGKYVDGTGMLRSQSEEEEDVFGIQRRRSSLGLSGCPLTEEEPGPGGPLTQPLRRIISIEEDPLPQLLGGGFQQPLSKCLEEKEASGQGVNEQSGPARPLGLTPTSPRGQPVGKEALSEEEGFPSTPDRLFKIVFVGNSSVGKTSFLGRFCDGRFSPGSAATVGIDYRVKTVRVDDSRVAVQLWDTAGQERYRCITQQFFRKADGVVVMYDLTARQSFLDVRQWLSSVEEAVGDRIPVLLLANKIDNEKEREVPRGLGEQLAKEHDLIFYECSAYSGHNTEEPVLHLARILKEQEDTVREDTIQVDRPAKKKACCG", "length": 723, "header": "tr|E1BER4-1|E1BER4_BOVIN Isoform 1 of Calcium release activated channel regulator 2A OS=Bos taurus OX=9913 GN=CRACR2A PE=4 SV=3 CANONICAL=E1BER4-1" }, "isoforms": [ { "isoform_ac": "E1BER4-1", "url": "https://www.uniprot.org/uniprotkb/E1BER4/entry#E1BER4-1", "sequence": { "sequence": "MATIDGRMVSRPRGSGRGRQGSGACLGSLDDLPCEGTQELAATQLAMLRRAQEFFQTCDKEGKGFIARADMQRLHKELPLSLEDLEDVFDTLDADGNGFLTPEEFTTGFSHFFFSQNNPSQEDAGAQPAQLQEEKVYQSRGDEDLGDMDEDEEAQFQTLMDRLGAQKVLEDEADVKQLWLQLKKDEPHLLSNFEDFLTRIFSQLLEAHEEKNELECALKKKIAAYDEEIQHLYEEMEQQIKTEKEQFLLKDTERFRARSQELERKLLSKEQELEQLVQKQKRLEGQCTALHNDKHETKAENTKLRLTNQELARELERTSRELQDAQQQLESLRQEAHKLHQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDEQDIRFQKDKAARANTAAPTARWKQRSGSVIGKYVDGTGMLRSQSEEEEDVFGIQRRRSSLGLSGCPLTEEEPGPGGPLTQPLRRIISIEEDPLPQLLGGGFQQPLSKCLEEKEASGQGVNEQSGPARPLGLTPTSPRGQPVGKEALSEEEGFPSTPDRLFKIVFVGNSSVGKTSFLGRFCDGRFSPGSAATVGIDYRVKTVRVDDSRVAVQLWDTAGQERYRCITQQFFRKADGVVVMYDLTARQSFLDVRQWLSSVEEAVGDRIPVLLLANKIDNEKEREVPRGLGEQLAKEHDLIFYECSAYSGHNTEEPVLHLARILKEQEDTVREDTIQVDRPAKKKACCG", "length": 723, "header": "tr|E1BER4-1|E1BER4_BOVIN Isoform 1 of Calcium release activated channel regulator 2A OS=Bos taurus OX=9913 GN=CRACR2A PE=4 SV=3 CANONICAL=E1BER4-1" }, "locus": { "chromosome": "5", "start_pos": 106298763, "end_pos": 106227291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063568.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063568.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054471.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054471.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525377", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525377", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A629-1", "protein_name": "Calcium release activated channel regulator 2A", "gene_name": "CRACR2A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRKAQEFFQTCDAGGKGFIARSDMQRLHKELPLSLEDLEDVFDALDADGNGFLTPGEFTTGFSHFFFSQNKPSQDDDAEEAAQLQTEKVYQSRGDEDPGDMDEDEEAQFQRLMDRLGAQKVLEDESDVKQLWLQLKKDEPHLLSNFEDFLTRIFLQLQEAHEEKNELECALKKKIAAYDEEIQHLYEEMEQQIKSEKEKFLLKDTERFQARSQELEQKLFLKEQELEQLIQKQKRLEGQCTALHNDKHETKAENTKLKLTNQELAQELERTARELQGAQQQLESLQQEACKLQEEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDIRLQKDKAAKANTAASTAGWKQRSGSVIGKYVDDRGILRSQSEEEEDVFGISRRRSSLGLSGYPLTEEEPGPGGPLPRALRRIISIEEDPLPQLLRGSSEQPLGKCPEEEEVSDQGVEGPLQQAPPQGLTPASPRGQPVGKEALSEEEGSAFTPDRLFKIVFVGNSAVGKTSFLGRFCDGRFSPGSAATVGIDYRVKTVRVDDSKVALQLWDTAGQERYRCITQQFFRKADGVAIMYDLTARQSFLAVRQWLSSVEEAVGDRIPVLLLGNKIDNEKEREVPRGLGEQLAKENNLIFYECSAFSGHNAEESLLHLARILKEQEDTVREETVQVDRLTKKKACCG", "length": 677 }, "evidence": [ { "id": "E1BER4", "url": "https://omabrowser.org/oma/group/E1BER4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZRP8-1", "protein_name": "small monomeric GTPase", "gene_name": "Cracr2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATPSGREDSSSQAPCHGEQGSEACVEELDHPERLEAEVPDQSVMWKKAQEFFQTCDSEGKGFIARTDLQRLHKELPLSLEELEDVFDALDADSNGFLTPEEFATGFSHFFFSQNSQREEDAGQQVVQLQEEKVYQSRGEEDMGGVDQDEEAQFQMLMDRLGAQKILDDESDVRQLWLQLKKDEPHLLSNFEDLLTTIFTQLQEAHEQKNELECALRKKIAAYDEEIQHLYEEMEQQIKSEREQFLLKDTERFQARSRELEKKLSAKEQELERLNQKQRRLEGQCAALHNDKHETKAENSKLRLTNQELARELERTSQQLQEAQQQLESLQREACELQQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDITFQKDKAARASTAASKANRKQRSGSVIGKYVDGRGILRSQSQEEEEVFGPLRRRSSVGLSAYLQAEEELGTGEPGTGVPRRQALRRIISIEEDPLPQLLEGGFEKPLNKCPEEEEPSDQGTEGQSVAAPVLDLIPSSPRGQPVGKETLYKEERVSSAPDRLFKIVFVGDSAVGKTSFLRRLCEARFSPGMAATVGIDYRVKTVTVDNAQVALQLWDTAGQERYRCISQQFFRKADGVVVMYDLTAKQSFLSIRQWLSSVEEAVGDRIPVLLLGNKLDNEKEREVPRGLGEQLAKENNLIFYECSACSGHNTKESLLHLARLLKEQEDTVRKDIIQVGPPAKKKSCCG", "length": 726 }, "evidence": [ { "id": "E1BER4", "url": "https://omabrowser.org/oma/group/E1BER4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UP38-2", "protein_name": "EF-hand calcium-binding domain-containing protein 4B", "gene_name": "Cracr2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATPSGREDSSSQTPGHGKQGSGACVEQLDHPEKLEVEMPDQSAMWKKAQEFFQTCDSEGKGFIARTDMQRLHQELPLSLEELEDVFDALDADGNGFLTPEEFTTGFSHFFFSQNIQGEEEADQQVAQLQEEKVYQSRGEEDVGDMDHDEEAQFQMLMDRLGAQKVLEDESDVRQLWLQLRKDEPHLLSNFEDLLTTIFAQLQEAHEQKNELECALRKKIAAYDEEIQHLYEEMEQQIKSEREQFLLKDTERFQARSRELEKKLSAKEQELERLNQKQRKLEGQCAALHNDKHETKAENSKLRLTNQELARELERTSHQLQEAQQQLESLQREACELQQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDITFQKDKAAKANTAASKASRKQRSGSVIGKYVDGRGILRSQSEEEEDVFSAPRRRSSVGLSAYLQAEEDLGTGEPGSGVPRRQALRRIISIEEDPLPQLLEGGFEKPLSRCPEEEEVSDQGTERQSVAAPVLDLIPTSPRGQPVGKETLYKEERVPSTPDRLFKIVFVGDSAVGKTSFLRRLCEARFSPGMAATVGIDYRVKTVTVDNAQVALQLWDTAGQERYRCISQQFFRKADGVAVMYDLTAKQSFLSIRQWLSSVEEAVGDRIPVLLLGNKLDNEKEREVPRGLGEQLAKENNLIFYECSACSGHNAQESLLHLARLLKEQEDTVRNDTIQVGPPAKKKSCCG", "length": 726 }, "evidence": [ { "id": "E1BER4", "url": "https://omabrowser.org/oma/group/E1BER4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" }, { "name": "positive regulation of calcium ion transport", "id": "GO:0051928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051928", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" }, { "name": "store-operated calcium entry", "id": "GO:0002115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002115", "evidence": [ { "database": "UniProtKB", "id": "E1BER4", "url": "https://www.uniprot.org/uniprotkb/E1BER4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 545, "end_pos": 547, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BER4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 723, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BER4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BER4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 545, "end_pos": 547 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BER7-1", "uniprot_ac": "E1BER7", "uniprot_id": "E1BER7_BOVIN", "mass": { "chemical_mass": 22622.0, "monoisotopic_mass": 22622.0 }, "refseq": { "ac": "XP_005215102", "name": "spermatogenesis-associated protein 25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215102" }, "gene_names": [ { "name": "SPATA25", "type": "recommended", "evidence": [ { "id": "E1BER7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER7" } ] }, { "name": "SPATA25", "type": "synonym", "evidence": [ { "id": "XP_005215102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215102" } ] } ], "protein_names": [ { "name": "Spermatosis associated 25", "type": "synonym", "evidence": [ { "id": "E1BER7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER7/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 25", "type": "synonym", "evidence": [ { "id": "XP_005215102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215102" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BER7", "url": "https://www.uniprot.org/uniprotkb/E1BER7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA25", "url": "https://www.uniprot.org/uniprotkb/E1BER7", "locus": { "chromosome": "13", "start_pos": 74643446, "end_pos": 74645678, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000960", "url": "https://www.ensembl.org/id/ENSBTAG00000000960" } ] } } ], "crossref": [ { "id": "E1BER7", "url": "https://alphafold.ebi.ac.uk/entry/E1BER7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000960", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000960", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101904713", "url": "https://www.ncbi.nlm.nih.gov/gene/101904713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWEDGCS", "url": "https://omabrowser.org/oma/group/GWEDGCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BER7", "url": "https://www.orthodb.org/?gene=E1BER7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36857:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36857:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215102", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215102", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BER7", "url": "https://www.uniprot.org/uniprotkb/E1BER7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BER7-1", "url": "https://www.uniprot.org/uniprotkb/E1BER7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYFMSPQTQPGLPSSGQGGAASPGSSLGLYSPIEPGMVASGGQGPLSQKAEQVTPVAQAWGPAPGGTGWEPPRQEYNWYCHKFPAARQLENLGREDSCSRSRAPQLGGLSRPAPLLLCGLSPGAPLMPAEAGGKEATSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPDGAVEGAQWAQAQTHIASGPMALARSRRGQPPGSYL", "length": 218, "header": "tr|E1BER7-1|E1BER7_BOVIN Isoform 1 of Spermatosis associated 25 OS=Bos taurus OX=9913 GN=SPATA25 PE=4 SV=1 CANONICAL=E1BER7-1" }, "isoforms": [ { "isoform_ac": "E1BER7-1", "url": "https://www.uniprot.org/uniprotkb/E1BER7/entry#E1BER7-1", "sequence": { "sequence": "MSYFMSPQTQPGLPSSGQGGAASPGSSLGLYSPIEPGMVASGGQGPLSQKAEQVTPVAQAWGPAPGGTGWEPPRQEYNWYCHKFPAARQLENLGREDSCSRSRAPQLGGLSRPAPLLLCGLSPGAPLMPAEAGGKEATSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPDGAVEGAQWAQAQTHIASGPMALARSRRGQPPGSYL", "length": 218, "header": "tr|E1BER7-1|E1BER7_BOVIN Isoform 1 of Spermatosis associated 25 OS=Bos taurus OX=9913 GN=SPATA25 PE=4 SV=1 CANONICAL=E1BER7-1" }, "locus": { "chromosome": "13", "start_pos": 74645479, "end_pos": 74644450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001269.3", "url": "https://www.ensembl.org/id/ENSBTAT00000001269.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000001269.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101904713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904713", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H8V7-1", "protein_name": "Spermatogenesis-associated protein 25", "gene_name": "Spata25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYFMSPQTHLGLLPSGQGGAAASGSSLGLYSSAEPVVVASGGLGPFSQKAEQVVPAAQAWGAPLAVPEARGCSGGASWETARRKEHNRYCPKLPPMRQLENLGWADPCSRSRAPHLGGPSRPRPLLLCGLSPGVLTVSSEAGGKEAGSQTDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGVQWEQAHAHMASGQMPLVRSRRGSCL", "length": 224 }, "evidence": [ { "id": "E1BER7", "url": "https://omabrowser.org/oma/group/E1BER7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9BR10-1", "protein_name": "Spermatogenesis-associated protein 25", "gene_name": "SPATA25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYFRTPQTHPGPLPSGQGGAASPGLSLGLCSPVEPVVVASGGTGPLSQKAEQVAPAAQAWGPALAMPQARGCPGGTSWETLRKEYSRNCHKFPHVRQLESLGWDNGYSRSRAPDLGGPSRPRPLMLCGLSPRVLPVPSEAVGKEASSQPDICILTLAMMIAGIPTVPVPGVREEDLIWAAQAFMMAHPEPEGAVEGARWEQAHAHTASGKMPLVRSKRGQPPGSCL", "length": 227 }, "evidence": [ { "id": "E1BER7", "url": "https://omabrowser.org/oma/group/E1BER7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DA57-1", "protein_name": "Spermatogenesis-associated protein 25", "gene_name": "Spata25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYFVSPQSHLGLLPSGQGGAASSGSSLGLYSPAEPVVVAPGGLGPLSQKAEQVAPAAQAWGPTLAVPEARGCSGGVSWETPRRKEHNRYCPKLPPMRPLESLGWADPCSRSRAPYLGGPSRPRPLLLCGLSPGVLPISSEAGGKEAASQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGVQWEQAHAHAHMASGQMPLVRSRRGSCL", "length": 226 }, "evidence": [ { "id": "E1BER7", "url": "https://omabrowser.org/oma/group/E1BER7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BER7", "url": "https://www.uniprot.org/uniprotkb/E1BER7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BER7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BER7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BER7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BES2-1", "uniprot_ac": "E1BES2", "uniprot_id": "E1BES2_BOVIN", "mass": { "chemical_mass": 68654.0, "monoisotopic_mass": 68654.0 }, "refseq": {}, "gene_names": [ { "name": "CHDH", "type": "recommended", "evidence": [ { "id": "E1BES2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ] } ], "protein_names": [ { "name": "Choline dehydrogenase", "type": "synonym", "evidence": [ { "id": "E1BES2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BES2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHDH", "url": "https://www.uniprot.org/uniprotkb/E1BES2", "locus": { "chromosome": "22", "start_pos": 47158681, "end_pos": 47066418, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010027", "url": "https://www.ensembl.org/id/ENSBTAG00000010027" } ] } } ], "crossref": [ { "id": "E1BES2", "url": "https://alphafold.ebi.ac.uk/entry/E1BES2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010027", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010027", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BES2", "url": "https://www.orthodb.org/?gene=E1BES2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11552", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11552", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11552:SF147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11552:SF147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05199", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05199", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RYA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BES2-1", "url": "https://www.uniprot.org/uniprotkb/E1BES2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWCVLRGWRGGCLGPWGALGAQGPRGLRALASKHPRSRGDYSHVVVGAGSAGCVLAGRLTEDPDQHVLLLEAGPKDVYAGSKRLCWKIHMPAALVANLCDDTYNWCYHTEPQAGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGAAGWDYAHCLPYFRRAQAHELGAGRYRGGDGPLRVSRGKSGHPLHRAFLEAAQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSTACAYLHPALSRPNLTAETQTFVRRVLFEGTRAVGVEYLKNGESHRKSRGQRSLAGYSPWGRKESDMTEQLSAQAYASKEVILSGGAINSPQLLMLSGVGNADDLRKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLKKAWIGLEWLWKFTGYGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPPQQEAYQVHVGTMRGTSVGWLKLRSANPHDHPVIQPNYLSTETDIKDFRLCVRLTREIFAQKALAPFRGKELQPGSHIQSDAEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSVVSGNLNAPTIMIAEKAADIIQGRPALWDEDVPVYKPRTLATQR", "length": 622, "header": "tr|E1BES2-1|E1BES2_BOVIN Isoform 1 of Choline dehydrogenase OS=Bos taurus OX=9913 GN=CHDH PE=3 SV=2 CANONICAL=E1BES2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BES2/entry#A0AAA9RYA7-1", "sequence": { "sequence": "MWCVLRGWRGGCLGPWGALGAQGPRGLRALASKHPRSRGDYSHVVVGAGSAGCVLAGRLTEDPDQHVLLLEAGPKDVYAGSKRLCWKIHMPAALVANLCDDTYNWCYHTEPQAGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGAAGWDYAHCLPYFRRAQAHELGAGRYRGGDGPLRVSRGKSGHPLHRAFLEAAQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSTACAYLHPALSRPNLTAETQTFVRRVLFEGTRAVGVEYLKNGESHRAYASKEVILSGGAINSPQLLMLSGVGNADDLRKLGIPVVCHLPGEPPSPLRPRGVGQNLQDHLEIYIQQACTRPITLHSAQKPLKKAWIGLEWLWKFTGYGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPPQQEAYQVHVGTMRGTSVGWLKLRSANPHDHPVIQPNYLSTETDIKDFRLCVRLTREIFAQKALAPFRGKELQPGSHIQSDAEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSVVSGNLNAPTIMIAEKAADIIQGRPALWDEDVPVYKPRTLATQR", "length": 604, "header": "tr|A0AAA9RYA7-1|A0AAA9RYA7_BOVIN Computationally mapped isoform of Choline dehydrogenase OS=Bos taurus OX=9913 GN=CHDH PE=3 SV=2 CANONICAL=E1BES2-1" }, "locus": { "chromosome": "22", "start_pos": 47157294, "end_pos": 47133970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078536.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078536.2" } ] } }, { "isoform_ac": "E1BES2-1", "url": "https://www.uniprot.org/uniprotkb/E1BES2/entry#E1BES2-1", "sequence": { "sequence": "MWCVLRGWRGGCLGPWGALGAQGPRGLRALASKHPRSRGDYSHVVVGAGSAGCVLAGRLTEDPDQHVLLLEAGPKDVYAGSKRLCWKIHMPAALVANLCDDTYNWCYHTEPQAGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGAAGWDYAHCLPYFRRAQAHELGAGRYRGGDGPLRVSRGKSGHPLHRAFLEAAQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSTACAYLHPALSRPNLTAETQTFVRRVLFEGTRAVGVEYLKNGESHRKSRGQRSLAGYSPWGRKESDMTEQLSAQAYASKEVILSGGAINSPQLLMLSGVGNADDLRKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLKKAWIGLEWLWKFTGYGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPPQQEAYQVHVGTMRGTSVGWLKLRSANPHDHPVIQPNYLSTETDIKDFRLCVRLTREIFAQKALAPFRGKELQPGSHIQSDAEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSVVSGNLNAPTIMIAEKAADIIQGRPALWDEDVPVYKPRTLATQR", "length": 622, "header": "tr|E1BES2-1|E1BES2_BOVIN Isoform 1 of Choline dehydrogenase OS=Bos taurus OX=9913 GN=CHDH PE=3 SV=2 CANONICAL=E1BES2-1" }, "locus": { "chromosome": "22", "start_pos": 47157294, "end_pos": 47133970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013227.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013227.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013227.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013227.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6798163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "resource": "Reactome", "description": "Choline catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "pmid": "" }, { "name": "choline dehydrogenase activity", "id": "GO:0008812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008812", "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on CH-OH group of donors", "id": "GO:0016614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016614", "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycine betaine biosynthetic process from choline", "id": "GO:0019285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019285", "evidence": [ { "database": "UniProtKB", "id": "E1BES2", "url": "https://www.uniprot.org/uniprotkb/E1BES2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BES2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 622, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BES2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BES2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BES2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BES2" }, { "id": "PS00623", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00623" }, { "id": "PS00624", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00624" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glucose-methanol-choline oxidoreductase N-terminal", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 148, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 253, "end_pos": 255 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BET1-1", "uniprot_ac": "E1BET1", "uniprot_id": "E1BET1_BOVIN", "mass": { "chemical_mass": 189595.0, "monoisotopic_mass": 189595.0 }, "refseq": { "ac": "NP_001193149", "name": "signal-induced proliferation-associated 1-like protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193149" }, "gene_names": [ { "name": "SIPA1L2", "type": "recommended", "evidence": [ { "id": "E1BET1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ] }, { "name": "SIPA1L2", "type": "synonym", "evidence": [ { "id": "NP_001193149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193149" } ] } ], "protein_names": [ { "name": "Signal induced proliferation associated 1 like 2", "type": "synonym", "evidence": [ { "id": "E1BET1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#names_and_taxonomy" } ] }, { "name": "signal-induced proliferation-associated 1-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001193149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193149" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIPA1L2", "url": "https://www.uniprot.org/uniprotkb/E1BET1", "locus": { "chromosome": "28", "start_pos": 5218869, "end_pos": 5336809, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000942", "url": "https://www.ensembl.org/id/ENSBTAG00000000942" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000942", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000942", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06745", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06745", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535132", "url": "https://www.ncbi.nlm.nih.gov/gene/535132", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535132", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535132", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYRVDSY", "url": "https://omabrowser.org/oma/group/GYRVDSY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NIL9", "url": "https://www.orthodb.org/?gene=A0A3Q1NIL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BET1", "url": "https://www.orthodb.org/?gene=E1BET1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11881", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11881", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193149", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDN8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDN8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKN4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKN4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIL9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIL9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BET1-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1719, "header": "tr|E1BET1-1|E1BET1_BOVIN Isoform 1 of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=3 CANONICAL=E1BET1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#A0A3Q1MDN8-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQHQRLHSSCSLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1710, "header": "tr|A0A3Q1MDN8-1|A0A3Q1MDN8_BOVIN Computationally mapped isoform of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=1 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5219977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070102.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070102.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068548.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068548.2" } ] } }, { "isoform_ac": "A0A3Q1MEI9-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#A0A3Q1MEI9-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNFPGGSVIKNPPANAGDREMWVRSLDEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1744, "header": "tr|A0A3Q1MEI9-1|A0A3Q1MEI9_BOVIN Computationally mapped isoform of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=1 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5219977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066793.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066793.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068910.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068910.2" } ] } }, { "isoform_ac": "A0A3Q1MKN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#A0A3Q1MKN4-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRSECLGRTAPASRALWDEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1716, "header": "tr|A0A3Q1MKN4-1|A0A3Q1MKN4_BOVIN Computationally mapped isoform of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=1 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5219977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068981.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068981.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071469.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071469.2" } ] } }, { "isoform_ac": "A0A3Q1MP51-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#A0A3Q1MP51-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSRLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKVNQSIGSCCSELFLLRNQPLLTTRNKKKDP", "length": 1608, "header": "tr|A0A3Q1MP51-1|A0A3Q1MP51_BOVIN Computationally mapped isoform of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=1 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5223243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068069.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068069.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073155.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073155.2" } ] } }, { "isoform_ac": "A0A3Q1NIL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#A0A3Q1NIL9-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1657, "header": "tr|A0A3Q1NIL9-1|A0A3Q1NIL9_BOVIN Computationally mapped isoform of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=1 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5219977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071882.1" } ] } }, { "isoform_ac": "E1BET1-1", "url": "https://www.uniprot.org/uniprotkb/E1BET1/entry#E1BET1-1", "sequence": { "sequence": "MSDPRQSQEEKHKLGRACSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLTASSSNESGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKTLWESRSQTSYESVTSIIHNGQNDGSEGQQEEPLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRLENYDHKAMAPFGFPEFFPCDPAISPSLHAAAQISRGEFVRISGLDYMDSALLLGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFACELEDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPAGPPGSCDSPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYVIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSVRREKVEDPKEKEGSQFNYRVVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVCTMLPHTPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVVARDFGQSADIECLLGVSNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLMSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGAPCEYKTPFRRNTTWHRVPTPALQPLPRVSPVPGTPDRLQCQPLLPQSQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGSSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTVEGSRHAETKWHGPPSKVLSSYKERGLQKDGGCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPAAVLGPVHLAGSRSLVHGRAEQWADSDIPGPDDEQAKMYAVHGYAPGISTSGAADGSLGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDTSKVYIVSHGSGQQAPGSMSKAYHRQAAVNKYIIGWKKSEDSPPPEEPEVAECQGLYSEMDLLSSAAQQQAVVGDAVSETQHVLSKEDFLKLMLPDSPSVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPVPSVGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMHPEQDLEGAQELPLCVDPGSGKDFMDPAGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1719, "header": "tr|E1BET1-1|E1BET1_BOVIN Isoform 1 of Signal induced proliferation associated 1 like 2 OS=Bos taurus OX=9913 GN=SIPA1L2 PE=4 SV=3 CANONICAL=E1BET1-1" }, "locus": { "chromosome": "28", "start_pos": 5336610, "end_pos": 5219977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001248.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001248.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001248.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001248.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 48, "start_aa": "Thr", "end_pos": 48, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 66, "start_aa": "Thr", "end_pos": 66, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr66", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535132", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535132", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y4J2-1", "protein_name": "Signal induced proliferation associated 1 like 2", "gene_name": "SIPA1L2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSDQRSLQEDKHKISRTSSKFRESSRSMQSDDYFARKLKALNGSMGPPVPSNASSKSESNQSNGTPAVPKMGVRARVSEWPPKKDCSKELSKAAWENRPQASYESVGSVHPNGQNDQNEGQQEELELEFAEGKYSIGDLFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENFEHKTLAPFGFPEFFHCDPSVSPSLHAAAQISRGEFVRISGLDYMDSALLIGRDREKSFKRRLKSETVETSLFRKLRTVKSEHETFKFSSDLDDRLDRNVRSWNCQKCFAHYDVQSILFNINEAMATRVNVGKRKNITTGASAASQTQMPAGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSASFSSGESCSFESSLSSHCTNAGVSVLEVPRENQSIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDPKEKEGSQFNYRIVFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVPEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNEMAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTMLPYMPSNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKNIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWNVIARDFGQSADIECLLGISNEFIMLIEKESKNVVFNCSCRDVIGWTSGLMSIKIFYERGECILLSAADNCAEDIREIVQRLEIVTRGCETTEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHEDGAPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPAGQPLSRASPILGTSDRLQCQQLLQQAQTAIPRSTSFDRKLPDGARSSPSNQSSSSDPGPSGSSQWRQQVGYDGCQSPLLHEHQGSGSLEIEGGRERDETLEGTRHSETKWHAPSTKILSSYKDRALQKDGSGKESPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDEKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMSAPLLAPLHLAGSRSGVHCRTEQWTESSETPGLDEDSAKMYAVHSYASAISASHMAEGSMGDLSEISSHSSGSHHSGSPSTHCSKKSGSLDTSKVYIVSQNSSQQISGSVSKPYHRQGAVSKYVIGWKKSEGSPTPEESEISECHEVYDDIDAVSASSPLQTSVRNAIVESQQVLSKEDFLKLMLPENISVEEGRRKFSFYGNLSPRRTLYRTLSDESICSNRRGSSYASSRSSMLDQALPNDILFSTTPPYHSTLPPRMSLTPGMGNLRNEFWFSDGSLSDKAKFNDPGLMPLPDTATGLDWSHLVDAARAFEGFDSDEELGPFCHHTPFLDQRVASFCTLDDMQHAQGLEGTQELPLDESPTDGKDFLEAAGEHAPTTLTGKVNQLEVILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTAAAQLRKFTEWFFNTIDKKS", "length": 1716 }, "evidence": [ { "id": "E1BET1", "url": "https://omabrowser.org/oma/group/E1BET1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LDU3-1", "protein_name": "Signal induced proliferation associated 1 like 2", "gene_name": "SIPA1L2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPAASLNSSSSNETGCPANGTPAMPKMGVRARVSEWPPKKDCSKELTCKAALWESRAQTSYESVASIMHNGQNDQGDGQQEEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKALAPFGVPEFFPCDPAISPSLHAAAQISRGEFVRLSGLDYMDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKSEHETFKFSSDLDDGRLERGVRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQAQVPAGQSGGCESPLGSKEDLNSKENLDADEGDGKSNELVLSCPYFRNETGGESDRRIALSRANSAPFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDPKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSVQCLRQASSSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTMLPHMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSVGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECILLSSVDSCAEDVREIVQRLGIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRKNTTWHRVPTPALQPLPRASPVPGTPDRLQCQPLLPQNQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGRSGPWRPQVGHDGCQSPLLLEHQGSSPLECEGSRDREDTAEGSRHSETKWHGPPSKILSSYKDRGLQKDGGCKDSPNKLSHIGEQSCSSHSSSNTLSSNASSTSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATVLGPVHLPGSRSLVHGRPEQWADAADIPGPDDEQAKLYAVHSYVPAISTSGATDGSLGDLSEISSHSSGSHHSGSPSTHCSKSTGSLDTSKVYIVSHSSGQQVPGSTTKPYHRHGAVNKFVIGWKKSEGSPPPEEPDVPECQGLYGEMELLSTAVPQQTVVGDAVPETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSHRRGSSFGSSRSSILDQALPNDILFSTTPPYHSTLPPRTQPAPSLGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTAMGLDWTHLVDAARAFEGLDSDEELGLLCHHASYLDQRVASFCPLADMQHGQDLEGAQDLPLCVDPGSGKDFMDATGVQSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNLRLQEESQTAAAQLRKFTEWFFNTIDKKP", "length": 1721 }, "evidence": [ { "id": "E1BET1", "url": "https://omabrowser.org/oma/group/E1BET1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5JCS6-1", "protein_name": "Signal-induced proliferation-associated 1-like protein 2", "gene_name": "Sipa1l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDPRPSQAEKHKLGRAASKFKDPSRAMQSDDYFARKFKAINGSMGPATLNTSSLSEGGGGGGGPANGTPAVPKMGVRARVSEWPPKKDCSKDLACKTLWESRSQSSYESATSIIQNGQNDQVDRQQEEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDITISDIDTEDVLDQHAVNPNTGAALHREYGSTSSIDRQGLSGENVFAMLRGYRIESYDPKVTSSFGFPDFFPCDTAISPSLHAAAQISRGEFVRISGLDYMDGGLLMGRDRDKPFKRRLKSESVETSLFRKLRTVKSEHETFKFTSDLEEGRLDRGIRPWSCQRCFAHYDVQSILFNINEAMATRASVGKRKNITTGASAASQTPVPVGPAGGCESPLGSKEDLNAKENPDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSASFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHVDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDPREKEGSQFNYRVAFRTSELTTLRGAILEDAVPSTARHGTARGLPLKEVLEYVIPELSIPCLRQAANSPKVPEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKNIRSHFQHVFVIVKVHNPCTENVCYSVGVFRSKDVPPFVPPIPKGVTFPRTGVFRDFLLAKGINAENAAHKSEKFRAMATRTRHEYLKDLAENFVTTTTVDTSAKFSFITLGAKKKERVKPRTDAHLFSIGAIMWHVVARYFGQSADIECLLGISNEFIMLIEKESKNVAFNCSCRDVIGWTSGLVSIKIFYERGECILLSSVDNSSEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHEDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPVSRASPVPGTPDRLQCQPLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCPSPLLLEPQGPGSVECDGSGDHEDLMEVGRLPETKWHGPPSKVLSSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTTPCMPATILGPMHLTGSRSLIHSRAEQWADAADVSGADEDPAKMYTLHGYASAISSSAADGSMGDLSEVSSHSSGSHRSGSPSTHCSKSTGSLDSSKVYIVTHSGGQQVPGAVAKPYHRQGAANKYVIGWKKSEGSPPPEEPEVTECPRIYGEMDIMSTASQHPAVVGDSVPEAQHVLSKDDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESVCSNRRGSSFASSRSSILDQALPNDILFSTTPPYHSTLPPRTHPAPSMGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTAAGLDWSHLVDAARAFEGLDSDEELGLLCHHASYLDQRVASFCTLTDLQHGQELEGAPELSLCVDPTSGKEFMDTPGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRTFTEWFFSTIDKKV", "length": 1722 }, "evidence": [ { "id": "E1BET1", "url": "https://omabrowser.org/oma/group/E1BET1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80TE4-1", "protein_name": "Signal-induced proliferation-associated 1-like protein 2", "gene_name": "Sipa1l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDPRPSQAEKHKLGRAAAKLKDPSRTMQADDYFARKFKAINGSMGPATLNTSSSSEGGGGGGGPANGTPAVPKMGVRARVSEWPPKKDCSKDLACKTLWESRSQSSYESVTSIIQNGQNDQGDRQPEEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDITISDIDTEDVLDQHAVNPNTGAALHREYGSTSSIDRQGLSGENVFAMLRGYRIESYDPKVTGSFGFPDFFPCDTAISPSLHAAAQISRGEFVRISGLDYMDGGLLMGRDRDKPFKRRLKSESVETSLFRKLRAVKSEHETFKFTSDLEEGRLDRGIRPWSCQRCFAHYDVQSILFNINEAMATRASVGKRKNITTGASAASQTPVPVGPAGGCESPLGSKEDLNSKENPDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSASFSSGESCSFESSLSSHCTNAGVSVLEVPRESQPIHREKVKRYIIEHVDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDPREKEGSQFNYRVAFRTSELTTLRGAILEDAVPSTARHGTARGLPLKEVLEYVIPELSIQCLRQAANSPKVPEQLLKLDEQGLSFQHKIGILYCRAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKNIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAKFSFITLGAKKKERVKPRKDAHLFSIGAIMWHVVARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKAFYERGECLLLSSVDNRSEDIREIVQRLLIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHEDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPVSRASPVPGTPDRLQCQPLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCPSPLLLEHQGPGSVECDGTGEQEDLLEGGRLPETKWHGPPSKVLSSYKERVLQKDGSCKESPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTTPCMPATILGPVHLTGSRSLMHSRAEQWADAADVSVADDDPAKMYALHGYASAISSSAADGSMGDLSEVSSHSSGSQHSGSPSAHCSKSTGSLDSSKVYIVTHGGGQQAPGAVTKPYHRQGAANKYVIGWKKSEGSPPPEEPEVTECPRIYGEMDIMSTATQHPAVVGDSVSETQHVLSKDDFLKLMLPDSPLVEEGRRKFSFYGNVSPRRSLYRTLSDESVCSNRRGSSFASSRSSILEQALPNDILFSTTPPYHSTLPPRTHPAPSMGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTAAGLDWSHLVDAARAFEGLDSDEELGLLCHHASYLDQRVASFCTLTDLQHGQELEGAPELSLCVDPTSGKEFMDTPGERSPSTLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFSTIDKKA", "length": 1722 }, "evidence": [ { "id": "E1BET1", "url": "https://omabrowser.org/oma/group/E1BET1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2F8-1", "protein_name": "Signal-induced proliferation-associated 1-like protein 2", "gene_name": "SIPA1L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETGGGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSDQSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS", "length": 1722 }, "evidence": [ { "id": "E1BET1", "url": "https://omabrowser.org/oma/group/E1BET1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "database": "UniProtKB", "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ], "pmid": "" }, { "name": "presynaptic signal transduction", "id": "GO:0098928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098928", "evidence": [ { "database": "UniProtKB", "id": "E1BET1", "url": "https://www.uniprot.org/uniprotkb/E1BET1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1121, "end_pos": 1123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1230, "end_pos": 1232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1473, "end_pos": 1475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 657, "end_pos": 659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 892, "end_pos": 894, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 48, 66 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 1121, "end_pos": 1123 }, { "start_pos": 1230, "end_pos": 1232 }, { "start_pos": 1473, "end_pos": 1475 }, { "start_pos": 354, "end_pos": 356 }, { "start_pos": 412, "end_pos": 414 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 657, "end_pos": 659 }, { "start_pos": 892, "end_pos": 894 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEU1-1", "uniprot_ac": "E1BEU1", "uniprot_id": "E1BEU1_BOVIN", "mass": { "chemical_mass": 78864.0, "monoisotopic_mass": 78864.0 }, "refseq": {}, "gene_names": [ { "name": "TTC12", "type": "recommended", "evidence": [ { "id": "E1BEU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 12", "type": "recommended", "evidence": [ { "id": "E1BEU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEU1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella.", "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1#function" }, { "database": "UniProtKB", "id": "ARBA00060127", "url": "https://www.uniprot.org/uniprotkb/ARBA00060127#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC12", "url": "https://www.uniprot.org/uniprotkb/E1BEU1", "locus": { "chromosome": "15", "start_pos": 23920998, "end_pos": 23874277, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010008", "url": "https://www.ensembl.org/id/ENSBTAG00000010008" } ] } } ], "crossref": [ { "id": "E1BEU1", "url": "https://alphafold.ebi.ac.uk/entry/E1BEU1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010008", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010008", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013105", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013105", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BEU1", "url": "https://www.orthodb.org/?gene=E1BEU1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46540", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46540", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46540:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46540:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07719", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07719", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEU1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADYQEEDLQKFLKNVDEITSLIQEMNSDDPVIREKAVLETEKRLQFTEGDQEEDECRTTVNKTVISPPQAPTKDADEINTEAFLASLEKDAKERAKRRRENKVLADALKEKGNAAFVRGDYETAILCYSEGLEKLKDMKVLYTNRAQAYIKLGDYRKALVDCDWALKFSFMQCDEKCTKAYFHMGKAHLALKNYSVSRECYQKILEINPQLQTQVKEYLNQVDLREKADVQEKEAQESLDSGKNSAVTTKNLLETLSKPDQIPLFYAGGIEILTEMMKDCTERTLFRTNNGFSIISENEVIRRCFSTAGKDAVEETVCLSVLRLWQAVCSENEENQRLLVLRPDTGPLLPSLLASRVPAIRQQSLALLLQLAQTENGRSLIIGHLDLIRLLEALVSFLDFSDKKANSAMGLLTDLALQERFQAWFQTSLPDVLPVLTGVLKRDPKVTNISALCQCLAIMGNFSAEAAAQRQMSASEDFGAACLGLMAKCEEDADLFRDVMYALLGLVMNLCLQSPFVSEVWAMEVSKKCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRAGVVKKMIKFLKAGGQTASRYAVKILAICTNSYQEAREEVLRLDKKLGVLMQLLDSEDEILVGNAALCLGNCMEVPRAASSLLSTDIVPVLLKLAGSDAQQTAVQLNAGIALGKLCTAEPRFAALLRELHGMEILNSTMKYVESS", "length": 710, "header": "tr|E1BEU1-1|E1BEU1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 12 OS=Bos taurus OX=9913 GN=TTC12 PE=4 SV=4 CANONICAL=E1BEU1-1" }, "isoforms": [ { "isoform_ac": "E1BEU1-1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1/entry#E1BEU1-1", "sequence": { "sequence": "MADYQEEDLQKFLKNVDEITSLIQEMNSDDPVIREKAVLETEKRLQFTEGDQEEDECRTTVNKTVISPPQAPTKDADEINTEAFLASLEKDAKERAKRRRENKVLADALKEKGNAAFVRGDYETAILCYSEGLEKLKDMKVLYTNRAQAYIKLGDYRKALVDCDWALKFSFMQCDEKCTKAYFHMGKAHLALKNYSVSRECYQKILEINPQLQTQVKEYLNQVDLREKADVQEKEAQESLDSGKNSAVTTKNLLETLSKPDQIPLFYAGGIEILTEMMKDCTERTLFRTNNGFSIISENEVIRRCFSTAGKDAVEETVCLSVLRLWQAVCSENEENQRLLVLRPDTGPLLPSLLASRVPAIRQQSLALLLQLAQTENGRSLIIGHLDLIRLLEALVSFLDFSDKKANSAMGLLTDLALQERFQAWFQTSLPDVLPVLTGVLKRDPKVTNISALCQCLAIMGNFSAEAAAQRQMSASEDFGAACLGLMAKCEEDADLFRDVMYALLGLVMNLCLQSPFVSEVWAMEVSKKCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRAGVVKKMIKFLKAGGQTASRYAVKILAICTNSYQEAREEVLRLDKKLGVLMQLLDSEDEILVGNAALCLGNCMEVPRAASSLLSTDIVPVLLKLAGSDAQQTAVQLNAGIALGKLCTAEPRFAALLRELHGMEILNSTMKYVESS", "length": 710, "header": "tr|E1BEU1-1|E1BEU1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 12 OS=Bos taurus OX=9913 GN=TTC12 PE=4 SV=4 CANONICAL=E1BEU1-1" }, "locus": { "chromosome": "15", "start_pos": 23920614, "end_pos": 23875686, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013201.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013201.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013201.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013201.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sperm axoneme assembly", "id": "GO:0007288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ], "pmid": "" }, { "name": "axonemal dynein complex assembly", "id": "GO:0070286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070286", "evidence": [ { "database": "UniProtKB", "id": "E1BEU1", "url": "https://www.uniprot.org/uniprotkb/E1BEU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 701, "end_pos": 703, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEU1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 710, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEU1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEU1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 462, "end_pos": 464 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 701, "end_pos": 703 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEW3-1", "uniprot_ac": "E1BEW3", "uniprot_id": "E1BEW3_BOVIN", "mass": { "chemical_mass": 112226.0, "monoisotopic_mass": 112226.0 }, "refseq": { "ac": "NP_001179861", "name": "importin-11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179861" }, "gene_names": [ { "name": "IPO11", "type": "recommended", "evidence": [ { "id": "E1BEW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ] }, { "name": "IPO11", "type": "synonym", "evidence": [ { "id": "NP_001179861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179861" } ] } ], "protein_names": [ { "name": "Importin-11", "type": "recommended", "evidence": [ { "id": "E1BEW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW3/entry#names_and_taxonomy" } ] }, { "name": "Ran-binding protein 11", "type": "synonym", "evidence": [ { "id": "E1BEW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW3/entry#names_and_taxonomy" } ] }, { "name": "importin-11", "type": "synonym", "evidence": [ { "id": "NP_001179861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179861" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IPO11", "url": "https://www.uniprot.org/uniprotkb/E1BEW3", "locus": { "chromosome": "20", "start_pos": 16791868, "end_pos": 16996143, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018616", "url": "https://www.ensembl.org/id/ENSBTAG00000018616" } ] } } ], "crossref": [ { "id": "E1BEW3", "url": "https://alphafold.ebi.ac.uk/entry/E1BEW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018616", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018616", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538236", "url": "https://www.ncbi.nlm.nih.gov/gene/538236", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538236", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538236", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BEW3", "url": "https://www.orthodb.org/?gene=E1BEW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10997:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10997:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179861", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEW3-1", "url": "https://www.uniprot.org/uniprotkb/E1BEW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKNGIDRYWRRVAPHALSEEEKSTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLSADRKLFYDLASGIYSFACSLWNHHTDTFLQQVSSGNEAAVLSSLERTLLSLKVLRKLTVNGIVEPHKNMEVMGFLHGIFERLKQFLECSRSIGADNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSNPATLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTAEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVRFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCVTPELLRIFQNMSPLLELSSESVRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTDGQVQVLKVVENALKVNPVLGPQMFQPILPCIFRGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQELLGEQGFQSLMETVDTEIVTQLQEFLQGF", "length": 975, "header": "tr|E1BEW3-1|E1BEW3_BOVIN Isoform 1 of Importin-11 OS=Bos taurus OX=9913 GN=IPO11 PE=3 SV=3 CANONICAL=E1BEW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUE2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEW3/entry#A0AAA9SUE2-1", "sequence": { "sequence": "MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKNGIDRYWRRVAPHALSEEEKSTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLSADRKLFYDGFLHGIFERLKQFLECSRSIGADNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSNPATLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTAEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVRFKSDLRPMLYEAICNLLQDQDLVYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCVTPELLRIFQNMSPLLELSSESVRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTDGQVQVLKVVENALKVNPVLGPQMFQPILPCIFRGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQELLGEQGFQSLMETVDTEIVTQLQEFLQGF", "length": 886, "header": "tr|A0AAA9SUE2-1|A0AAA9SUE2_BOVIN Computationally mapped isoform of Importin-11 OS=Bos taurus OX=9913 GN=IPO11 PE=3 SV=1 CANONICAL=E1BEW3-1" }, "locus": { "chromosome": "20", "start_pos": 16972465, "end_pos": 16793092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086742.1" } ] } }, { "isoform_ac": "E1BEW3-1", "url": "https://www.uniprot.org/uniprotkb/E1BEW3/entry#E1BEW3-1", "sequence": { "sequence": "MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKNGIDRYWRRVAPHALSEEEKSTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLSADRKLFYDLASGIYSFACSLWNHHTDTFLQQVSSGNEAAVLSSLERTLLSLKVLRKLTVNGIVEPHKNMEVMGFLHGIFERLKQFLECSRSIGADNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSNPATLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTAEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVRFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCVTPELLRIFQNMSPLLELSSESVRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTDGQVQVLKVVENALKVNPVLGPQMFQPILPCIFRGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQELLGEQGFQSLMETVDTEIVTQLQEFLQGF", "length": 975, "header": "tr|E1BEW3-1|E1BEW3_BOVIN Isoform 1 of Importin-11 OS=Bos taurus OX=9913 GN=IPO11 PE=3 SV=3 CANONICAL=E1BEW3-1" }, "locus": { "chromosome": "20", "start_pos": 16972465, "end_pos": 16793092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024773.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024773.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024773.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024773.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538236", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538236", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "E1BEW3", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 838, "end_pos": 840, "annotation": "n_glycosylation_sequon" }, { "start_pos": 872, "end_pos": 874, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEW3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 975, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEW3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEW3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW3" }, { "id": "PS50166", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50166" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Importin N-terminal", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 100, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 421, "end_pos": 423 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 691, "end_pos": 693 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 838, "end_pos": 840 }, { "start_pos": 872, "end_pos": 874 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEW9-1", "uniprot_ac": "E1BEW9", "uniprot_id": "E1BEW9_BOVIN", "mass": { "chemical_mass": 348519.0, "monoisotopic_mass": 348519.0 }, "refseq": { "ac": "XP_024834805", "name": "WD repeat-containing protein 87", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834805" }, "gene_names": [ { "name": "WDR87", "type": "recommended", "evidence": [ { "id": "E1BEW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW9" } ] }, { "name": "WDR87", "type": "synonym", "evidence": [ { "id": "XP_024834805", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834805" } ] } ], "protein_names": [ { "name": "WD repeat domain 87", "type": "synonym", "evidence": [ { "id": "E1BEW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW9/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 87", "type": "synonym", "evidence": [ { "id": "XP_024834805", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834805" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEW9", "url": "https://www.uniprot.org/uniprotkb/E1BEW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR87", "url": "https://www.uniprot.org/uniprotkb/E1BEW9", "locus": { "chromosome": "18", "start_pos": 47751754, "end_pos": 47763996, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038442", "url": "https://www.ensembl.org/id/ENSBTAG00000038442" } ] } } ], "crossref": [ { "id": "ENSBTAG00000038442", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038442", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509804", "url": "https://www.ncbi.nlm.nih.gov/gene/509804", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509804", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509804", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VVPLPWQ", "url": "https://omabrowser.org/oma/group/VVPLPWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEW9", "url": "https://www.orthodb.org/?gene=E1BEW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42968:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42968:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834805", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834805", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BEW9", "url": "https://www.uniprot.org/uniprotkb/E1BEW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BEW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSPRLIPLWKDFKYLLSDMIQKSKQNLDDLKTDVVVLSDRSQILFKESRHPQNMPLICYYFSDAHFFSSLSWVTTSTKEIQAVVWMKSKTEDMVEKRMFSMTDRLPPIQSMVHTGSFHILVVYCGDLLLRLFGDHLRSFKSLGVVPCRFNITCLCYDPGMKMLLSGILGAVVTWTIERSGRGLQIAHMVALPGDEFIHDIMLNGPNGSLIAMCENVVRVLERQGHGLLAEVKKFSSTISGSSITCCFTCSEQGFLYAGNKTGEIQVWNLNWGHSLHTFKAHFSSVICIRSQPEAHTLLTAGREGIIKEWNLTSGNLLRRLELGEELYRLQFIDGTTFFCQTTHSFSLRSLPFFYSLFNVCGSAPQQVRRVRCGSNWFRILCTTEDGLLRFVSPLTGNLLVITWPFSILDQATDWAYDPNKEELFVATGSPDVLVFDTTRSPCMAKYLLCTSPDSQDLVQCLAYGHFHLGRGLEGLMFSGYQSGVIRVLSQHSCARIETYIHFGSVLALSTLPGGLSGSRENSLLCSYGMDDYIHLSEAVLEGVRVKLRILASILCSCQLTHLILLPKSVGAITQTNCLRLWKFHDFLSSGSQDGSTFIETLPLHQCTIISFDVCLSLSLFVTGGSDGSVRIWNFHGRLIAMLDSSLHFGPLCFANDRGDLLVTFNQSLYLVSCLKLLPPTLLVRLSLMGLTDEVLEVPKPFIPSFFFSFETMFVPKYIYPGHGKQQLVGLESLVNHRAIAFDHNVPHVIEEDEQGSPVLLSSFKHDSGYMEVDVSQVKKPPYFHYVLPPQLQLTTWDELNPYQILRCYFGHRRKWLLAPDCYIPNSVIRARLWPEGSPIYLQCSLHSPVRELEWDKSQQFFFWHSRARAISDAEQYIHEKEDEDFLLTRASKDITYTVLTDAANRSWLGKKMSEIAINSLIETILSIIIHATPLKYQCCIGALGQIFASYQVSPPLRSETAHRLLDDTTNSNPLIRELAWEGLKRLGMITHLFAVPLAQGLMDKDDRVRNKTLSLMAETGVHSRTSLLNLVQNRETFREMQQEMVGDETLDRLLGLRAPDLQILHTQVSQRLNEDLTLYQGDEKPTFTLDVSGASELTALSKETDTVPEEPEAAFKHSKGPRRSRPVVRKHTRKFLRSLKKLKETVTEPGPLQDEGDQSEAAPTEMEEARSSASSILKVAKDDEQESLEVDASKDHVALTMKMLRKTRDKRGRKSVSQKTMKRRKRKVTDTEITHEGFPHTEKTDSIMRPMQVTGRGASGAPGLRSRDSSMWRDDLCRLMTLRISGSQTKMLEALNNELVTTAQEMLADRQPSWELFQEICPLLKKDSEELLEDLDWDVAWPEEKPVFIHGSAIREDMMIRDMEEETRETQKRKTEKDIQDLRETHVSPKKGKKKKVLFAEPDLSKGKRISKKEEKKSSKPSKQRKAVQQEIKVDKKEKKIAKEERGMSQEVEVVDKLKEKVVEQEKKPLKDEIKLSWQEWKKSWDQWKNAFGETRISWDEWKKTWESQRHQEEEQVPEEEEKLLPDAEEGQVRRDKTKRTWDEWSQIWEKMSARAREKMLVTQEEVTLEEELPQEQEEEAEATAAEEEALMTEEQRQIHQEYKQAQVERKRAQAERRRAQEERKLAQEEEKLAQEEKRLAQEERKMVQEYEKLAEKDRKMVQMERKLIQNEEKLAQIEEMLSQDAEKLAQQRKRLAKKLEKLARAEENIAKKGGKLAEVKKIMMQKLDKLAQKELDLAWQEKELAQELEDLTWEEEELALKEEELNQEEEELINEGDRLDQEEMTLASQEEKLDAEEKAVIQEEELLVQEKRRLAQDKQNLSEKKEGLDQKREQLMENKHNLAQEEELLIQEEKELAQDKVKLPGEEEKLTEKREQLMEKKQKLAQEEELLIQEEKKLAQNMETLPVKEAKIAQKAEKFIKNKQKLAWEKTKLVQNMEELPKAKEILAWRQKNLAQEKEKLAQEKVKLAQRRETLIRLQESLIQSRKKSVPEKEVYDMYKNRLVQIEKKLMEEKEKLFQKKEKLATVEEKLTQLEKSLAEKQHKVAHDKMKLALGKRAVFQELNQLRGDWSITREEKALDMEMKILTWEKETLAEQKEILFKEETQETSKEKRLPKDELEVIKRKLSLEEKILLYEERILATEQTDMAKEKLEFTRGERVYAQEQRKLARLLRKLTEESKGISKEPLKVSSKVLKTLQGLIKEERKLTQEEIEMTKLKRLFVLKERELNKVQNELDAKEWDFSEEQPEITIDEKKLAKRQRRLAKEIRRLIKREKNITEQESILARQQRDVIQETDEEETTEEEEAKSFLKHKSRKREKLKTADTQQEELLSQEDEVKSVKSEEISSEEMECLLDEIEQESLSEEEEEEEEEEEEEEEEEEEEEEMEEEEVKEKKMVEKELGKEEEEGKERKKKRKKKKKKKVLEKEEKEEGKEEVVEEESTSDEEMEHLSEKEEREDRSLFEEEVDKKKAIFKREKIYKLLEGKKHLRGREEFLSIEKRIPDIKSSAVKLESPPKQLISVVLGSKEKISEPLLTKQISWEDKAIALGKPGVFPGAGFIDKQELLKKYKPMPLHVLDIVLEAQEPDLETPYLSHILRKTIEAQKLQGKPLGAKWQWILQRHPSLKKQSEVQLPLSKILPEEIYTDISVSDVEWIHHVLEKMEAGEQLSRDSFHRLCQLLKDLTAKENLEWMHLAKLEAIVYHHKQIMESRGTHISKPSKEPLGPKYLKVIPPIKGREKESWLKRLAVSTPKSLLATKGIPDPKAINWHLLGEPYRSARAKQIATSLRGMEMRYYDSATRDIFTGALDPVEKQTLALMFQKDFLAFKDKSRFARLPKLEKKARPISKVKEEVPLWETFVALYHVLRMLQERYARDSAAWMEQFNRLMELYQLKSPRIQKLMQDLLLREKPQFQEVTYKDALRAAELAPGERLFYHLLCGGSQAHKGPLAFQEVVPLPRQNNVQTMLPMGIAQYGILELAWKSLPEADLHLTNELPYVAAPTL", "length": 3003, "header": "tr|E1BEW9-1|E1BEW9_BOVIN Isoform 1 of WD repeat domain 87 OS=Bos taurus OX=9913 GN=WDR87 PE=4 SV=3 CANONICAL=E1BEW9-1" }, "isoforms": [ { "isoform_ac": "E1BEW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BEW9/entry#E1BEW9-1", "sequence": { "sequence": "MTSPRLIPLWKDFKYLLSDMIQKSKQNLDDLKTDVVVLSDRSQILFKESRHPQNMPLICYYFSDAHFFSSLSWVTTSTKEIQAVVWMKSKTEDMVEKRMFSMTDRLPPIQSMVHTGSFHILVVYCGDLLLRLFGDHLRSFKSLGVVPCRFNITCLCYDPGMKMLLSGILGAVVTWTIERSGRGLQIAHMVALPGDEFIHDIMLNGPNGSLIAMCENVVRVLERQGHGLLAEVKKFSSTISGSSITCCFTCSEQGFLYAGNKTGEIQVWNLNWGHSLHTFKAHFSSVICIRSQPEAHTLLTAGREGIIKEWNLTSGNLLRRLELGEELYRLQFIDGTTFFCQTTHSFSLRSLPFFYSLFNVCGSAPQQVRRVRCGSNWFRILCTTEDGLLRFVSPLTGNLLVITWPFSILDQATDWAYDPNKEELFVATGSPDVLVFDTTRSPCMAKYLLCTSPDSQDLVQCLAYGHFHLGRGLEGLMFSGYQSGVIRVLSQHSCARIETYIHFGSVLALSTLPGGLSGSRENSLLCSYGMDDYIHLSEAVLEGVRVKLRILASILCSCQLTHLILLPKSVGAITQTNCLRLWKFHDFLSSGSQDGSTFIETLPLHQCTIISFDVCLSLSLFVTGGSDGSVRIWNFHGRLIAMLDSSLHFGPLCFANDRGDLLVTFNQSLYLVSCLKLLPPTLLVRLSLMGLTDEVLEVPKPFIPSFFFSFETMFVPKYIYPGHGKQQLVGLESLVNHRAIAFDHNVPHVIEEDEQGSPVLLSSFKHDSGYMEVDVSQVKKPPYFHYVLPPQLQLTTWDELNPYQILRCYFGHRRKWLLAPDCYIPNSVIRARLWPEGSPIYLQCSLHSPVRELEWDKSQQFFFWHSRARAISDAEQYIHEKEDEDFLLTRASKDITYTVLTDAANRSWLGKKMSEIAINSLIETILSIIIHATPLKYQCCIGALGQIFASYQVSPPLRSETAHRLLDDTTNSNPLIRELAWEGLKRLGMITHLFAVPLAQGLMDKDDRVRNKTLSLMAETGVHSRTSLLNLVQNRETFREMQQEMVGDETLDRLLGLRAPDLQILHTQVSQRLNEDLTLYQGDEKPTFTLDVSGASELTALSKETDTVPEEPEAAFKHSKGPRRSRPVVRKHTRKFLRSLKKLKETVTEPGPLQDEGDQSEAAPTEMEEARSSASSILKVAKDDEQESLEVDASKDHVALTMKMLRKTRDKRGRKSVSQKTMKRRKRKVTDTEITHEGFPHTEKTDSIMRPMQVTGRGASGAPGLRSRDSSMWRDDLCRLMTLRISGSQTKMLEALNNELVTTAQEMLADRQPSWELFQEICPLLKKDSEELLEDLDWDVAWPEEKPVFIHGSAIREDMMIRDMEEETRETQKRKTEKDIQDLRETHVSPKKGKKKKVLFAEPDLSKGKRISKKEEKKSSKPSKQRKAVQQEIKVDKKEKKIAKEERGMSQEVEVVDKLKEKVVEQEKKPLKDEIKLSWQEWKKSWDQWKNAFGETRISWDEWKKTWESQRHQEEEQVPEEEEKLLPDAEEGQVRRDKTKRTWDEWSQIWEKMSARAREKMLVTQEEVTLEEELPQEQEEEAEATAAEEEALMTEEQRQIHQEYKQAQVERKRAQAERRRAQEERKLAQEEEKLAQEEKRLAQEERKMVQEYEKLAEKDRKMVQMERKLIQNEEKLAQIEEMLSQDAEKLAQQRKRLAKKLEKLARAEENIAKKGGKLAEVKKIMMQKLDKLAQKELDLAWQEKELAQELEDLTWEEEELALKEEELNQEEEELINEGDRLDQEEMTLASQEEKLDAEEKAVIQEEELLVQEKRRLAQDKQNLSEKKEGLDQKREQLMENKHNLAQEEELLIQEEKELAQDKVKLPGEEEKLTEKREQLMEKKQKLAQEEELLIQEEKKLAQNMETLPVKEAKIAQKAEKFIKNKQKLAWEKTKLVQNMEELPKAKEILAWRQKNLAQEKEKLAQEKVKLAQRRETLIRLQESLIQSRKKSVPEKEVYDMYKNRLVQIEKKLMEEKEKLFQKKEKLATVEEKLTQLEKSLAEKQHKVAHDKMKLALGKRAVFQELNQLRGDWSITREEKALDMEMKILTWEKETLAEQKEILFKEETQETSKEKRLPKDELEVIKRKLSLEEKILLYEERILATEQTDMAKEKLEFTRGERVYAQEQRKLARLLRKLTEESKGISKEPLKVSSKVLKTLQGLIKEERKLTQEEIEMTKLKRLFVLKERELNKVQNELDAKEWDFSEEQPEITIDEKKLAKRQRRLAKEIRRLIKREKNITEQESILARQQRDVIQETDEEETTEEEEAKSFLKHKSRKREKLKTADTQQEELLSQEDEVKSVKSEEISSEEMECLLDEIEQESLSEEEEEEEEEEEEEEEEEEEEEEMEEEEVKEKKMVEKELGKEEEEGKERKKKRKKKKKKKVLEKEEKEEGKEEVVEEESTSDEEMEHLSEKEEREDRSLFEEEVDKKKAIFKREKIYKLLEGKKHLRGREEFLSIEKRIPDIKSSAVKLESPPKQLISVVLGSKEKISEPLLTKQISWEDKAIALGKPGVFPGAGFIDKQELLKKYKPMPLHVLDIVLEAQEPDLETPYLSHILRKTIEAQKLQGKPLGAKWQWILQRHPSLKKQSEVQLPLSKILPEEIYTDISVSDVEWIHHVLEKMEAGEQLSRDSFHRLCQLLKDLTAKENLEWMHLAKLEAIVYHHKQIMESRGTHISKPSKEPLGPKYLKVIPPIKGREKESWLKRLAVSTPKSLLATKGIPDPKAINWHLLGEPYRSARAKQIATSLRGMEMRYYDSATRDIFTGALDPVEKQTLALMFQKDFLAFKDKSRFARLPKLEKKARPISKVKEEVPLWETFVALYHVLRMLQERYARDSAAWMEQFNRLMELYQLKSPRIQKLMQDLLLREKPQFQEVTYKDALRAAELAPGERLFYHLLCGGSQAHKGPLAFQEVVPLPRQNNVQTMLPMGIAQYGILELAWKSLPEADLHLTNELPYVAAPTL", "length": 3003, "header": "tr|E1BEW9-1|E1BEW9_BOVIN Isoform 1 of WD repeat domain 87 OS=Bos taurus OX=9913 GN=WDR87 PE=4 SV=3 CANONICAL=E1BEW9-1" }, "locus": { "chromosome": "18", "start_pos": 47763053, "end_pos": 47751916, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054630.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054630.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048323.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048323.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509804", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509804", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6ZQQ6-1", "protein_name": "WD repeat-containing protein 87", "gene_name": "WDR87", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSPRLIPLWKDLKLLLNDTINKSKQPSEDPKNCLIVLSDRSQAVAWMKSKTEDMVEKRTFSMTERLPPIQSMVHAGSFHILVVYCGDLILRLFGDHFRAFKPLGKVPCRFNISCLCYDPEMKMLLSGILGAVVTWVIELGGTGLQIAHMVSMPGDELVQDIVLNGPSGSLLALCETVVRVLMHQGKGQLGEVKRFTSTSSGSSITCCFTCFDQGFLYAGNQAGEIQVWSLQQGHPLHSFQAHQSGVICIRSRPEAHTLLTAGSDSLIKEWNLTSGSLLRRLELGEELYRLQFIDSITFFCQTAHSFSLHRLPCFYSLFNVCGSAPQQLRRVCCGNNWFRILCTTEDGLLRFVSPVTGDLLVITWPFSILDQAVDWAYDPGKEELFVATGSSEVLVFDTTRCPCPAKYLLGTSPNSQDFVQCLAYGHFNLGRGLEGLIFSGHQSGVIRVLSQHSCARLEKFMHFGAVLALSTLSGGIFGGQGNSLLCSYGMDDYVHLSEAVLDGVKVQLRPLASILSSCHLTHLILLPKSVGAITETNCLRLWKFHDFLSSGSQNGLKFIETLPLHLCAITSFDVCLSLSLFVTGSADGSVRIWDFHGRLIGILDSSLHFGPVCFANDRGDLLVTFNQSLYLVSCLKLLPPALLTRLSFMSISDEVLEVPKPFIPSFFFSFETMFVPKYIYPGQAQQKLVGLEKLVNNRAIAFDHSVPHVIEEDEEGSPVLLRSSMHYSLQDMEDWMQVSKRYQCHYVLPPQLQLTSWDGLNPYQILRYYFGHGREWLFAPDCYIPNSVIRARLWPEGTPIYLQCNLHAPQRELEWDRSQEFFFWHSRVRAISNTEYPKNKEEDEHFLEMRLSKDVTYSVLTDGANRSWLGRKMSEITINSMIETMLNIMVHASLLKYQCCVGALGQIFASYQVSPALRSETARRLLNDTTNSNPLIRELAWEGLKRLGMITHLFAMPLAQGLMDKDERVRIKTLSLMAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEEREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADVSLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQALESQDTRISSRQSMSPKYLKVIPPIKAKEKESWPKPLAVPTQKSPLATKRIPDPRAKNWHLLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFPSAHASVEKQTLALMFQKDFWDFKDKRRFPKLPKLEKKTQPISKKKEELPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDLYQLKSPRIQKLLQELLMREEPQPQEIIYEEALKATELVPGERLFCCLFCGSSHTPRSPQEFQGAVPLPWQNCVRTILPVGIARYGILELAWKSLPEADLHLTKALTHTVAPTL", "length": 2873 }, "evidence": [ { "id": "E1BEW9", "url": "https://omabrowser.org/oma/group/E1BEW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1822, "end_pos": 1824, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2278, "end_pos": 2280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" }, { "start_pos": 905, "end_pos": 907, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1011, "end_pos": 1013 }, { "start_pos": 151, "end_pos": 153 }, { "start_pos": 1822, "end_pos": 1824 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 2278, "end_pos": 2280 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 666, "end_pos": 668 }, { "start_pos": 905, "end_pos": 907 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BEZ4-1", "uniprot_ac": "E1BEZ4", "uniprot_id": "E1BEZ4_BOVIN", "mass": { "chemical_mass": 65039.0, "monoisotopic_mass": 65039.0 }, "refseq": {}, "gene_names": [ { "name": "TRIM29", "type": "recommended", "evidence": [ { "id": "E1BEZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ] } ], "protein_names": [ { "name": "Tripartite motif-containing protein 29", "type": "recommended", "evidence": [ { "id": "E1BEZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4#function" }, { "database": "UniProtKB", "id": "ARBA00056595", "url": "https://www.uniprot.org/uniprotkb/ARBA00056595#function" }, { "database": "UniProtKB", "id": "A0A3Q1MGC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM29", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4", "locus": { "chromosome": "15", "start_pos": 30685078, "end_pos": 30712148, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009419", "url": "https://www.ensembl.org/id/ENSBTAG00000009419" } ] } } ], "crossref": [ { "id": "E1BEZ4", "url": "https://alphafold.ebi.ac.uk/entry/E1BEZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009419", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009419", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19840", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19840", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525062", "url": "https://www.ncbi.nlm.nih.gov/gene/525062", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YMNSYTS", "url": "https://omabrowser.org/oma/group/YMNSYTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGC2", "url": "https://www.orthodb.org/?gene=A0A3Q1MGC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BEZ4", "url": "https://www.orthodb.org/?gene=E1BEZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MGC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAADASRSSGASPEVRDVRSSLSPNGSLENGVKAEGKEAKTANGHGGEVAEGKGAGGALKPGEGKSSLFSGSEWRRPIIQFVESVDDKGSSYFSMDSGEGRRSPYAGLQLGAAKKPPVTFAEKGEPRRSIFSEPRKPSVSIVEPGDIRRNSYPRGDSSTLLRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQSFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALEERAKVLQDDKQIREQLHSISDSVLFLQEFGALMSSYSLPPPLPTYHVLLEGEGLGQALGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYSNSYTSEWSAPDAMKRYSMYLTPKGGARTSYQPASPSRLSKEKNFNNLYGTKGNYTSRVWEYSSTIQSSDDVPAVQGSSSFSLKGYPSLIRSQSPKAQPQTWKSGKQTLLSHYRPFYVNKGNGIGSNEAP", "length": 584, "header": "tr|E1BEZ4-1|E1BEZ4_BOVIN Isoform 1 of Tripartite motif-containing protein 29 OS=Bos taurus OX=9913 GN=TRIM29 PE=4 SV=3 CANONICAL=E1BEZ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4/entry#A0A3Q1MGC2-1", "sequence": { "sequence": "MEAADASRSSGASPEVRDVRSSLSPNGSLENGVKAEGKEAKTANGHGGEVAEGKGAGGALKPGEGKSSLFSGSEWRRPIIQFVESVDDKGSSYFSMDSGEGRRSPYAGLQLGAAKKPPVTFAEKGEPRRSIFSEPRKPSVSIVEPGDIRRNSYPRGDSSTLLRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQSFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALEERAKVLQDDKQIREQLHSISDSVLFLQEFGALMSSYSLPPPLPTYHVLLEGEGLGQALGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYSNSYTSEWSAPDAMKRYSMYLTPKGGARTSYQPASPSRLSKEKNFNNLYGTKGNYTSRVWEYSSTIQSSDDVPAVQGSSSFSLKGTGKVPYQFTTLGQATTEFSKPLDGSGLFKNNPGYPSLIRSQSPKAQPQTWKSGKQTLLSHYRPFYVNKGNGIGSNEAP", "length": 617, "header": "tr|A0A3Q1MGC2-1|A0A3Q1MGC2_BOVIN Computationally mapped isoform of Tripartite motif-containing protein 29 OS=Bos taurus OX=9913 GN=TRIM29 PE=4 SV=1 CANONICAL=E1BEZ4-1" }, "locus": { "chromosome": "15", "start_pos": 30712078, "end_pos": 30685850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079309.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079309.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068048.1" } ] } }, { "isoform_ac": "E1BEZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4/entry#E1BEZ4-1", "sequence": { "sequence": "MEAADASRSSGASPEVRDVRSSLSPNGSLENGVKAEGKEAKTANGHGGEVAEGKGAGGALKPGEGKSSLFSGSEWRRPIIQFVESVDDKGSSYFSMDSGEGRRSPYAGLQLGAAKKPPVTFAEKGEPRRSIFSEPRKPSVSIVEPGDIRRNSYPRGDSSTLLRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQSFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALEERAKVLQDDKQIREQLHSISDSVLFLQEFGALMSSYSLPPPLPTYHVLLEGEGLGQALGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYSNSYTSEWSAPDAMKRYSMYLTPKGGARTSYQPASPSRLSKEKNFNNLYGTKGNYTSRVWEYSSTIQSSDDVPAVQGSSSFSLKGYPSLIRSQSPKAQPQTWKSGKQTLLSHYRPFYVNKGNGIGSNEAP", "length": 584, "header": "tr|E1BEZ4-1|E1BEZ4_BOVIN Isoform 1 of Tripartite motif-containing protein 29 OS=Bos taurus OX=9913 GN=TRIM29 PE=4 SV=3 CANONICAL=E1BEZ4-1" }, "locus": { "chromosome": "15", "start_pos": 30712078, "end_pos": 30685850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012396.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012396.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012396.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012396.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K659-1", "protein_name": "Tripartite motif-containing protein 29", "gene_name": "Trim29", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGADASRSNGASPEARDARSPPGPNGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEARRNSYPRADSSLLLRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCDLHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPNRLSKETNLKNFNNLYGTKGNYTSRVWEYSSTVQNADDMPTVQGNSSFSLKGYPSLLRSQVPKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP", "length": 587 }, "evidence": [ { "id": "E1BEZ4", "url": "https://omabrowser.org/oma/group/E1BEZ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14134-1", "protein_name": "Tripartite motif-containing protein 29", "gene_name": "TRIM29", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSSPGRFTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQSPKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP", "length": 588 }, "evidence": [ { "id": "E1BEZ4", "url": "https://omabrowser.org/oma/group/E1BEZ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R2Q0-1", "protein_name": "Tripartite motif-containing protein 29", "gene_name": "Trim29", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGADACRSNGASPEARDTRSPPGPSGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEVRRNSYPRADSSLLARAKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDDVEKWQKEKDRIKSFTTNEKAILEQNFRDLVRELEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHNISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNSYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPSRLSKETNQKNFNNLYGTKGNYTSRVWEYTSTVQNSEDMPTVQGNSSFSLKGFPSLLRSQVPKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP", "length": 587 }, "evidence": [ { "id": "E1BEZ4", "url": "https://omabrowser.org/oma/group/E1BEZ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BEZ4", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BEZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 584, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BEZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BEZ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BEZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ4" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 260, "start_aa": "Phe", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 508, "end_pos": 510 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF01-1", "uniprot_ac": "E1BF01", "uniprot_id": "E1BF01_BOVIN", "mass": { "chemical_mass": 152479.0, "monoisotopic_mass": 152479.0 }, "refseq": { "ac": "XP_010807869", "name": "pleckstrin homology domain-containing family H member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807869" }, "gene_names": [ { "name": "PLEKHH1", "type": "recommended", "evidence": [ { "id": "E1BF01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF01" } ] }, { "name": "PLEKHH1", "type": "synonym", "evidence": [ { "id": "XP_010807869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807869" } ] } ], "protein_names": [ { "name": "Pleckstrin homology, MyTH4 and FERM domain containing H1", "type": "synonym", "evidence": [ { "id": "E1BF01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF01/entry#names_and_taxonomy" } ] }, { "name": "pleckstrin homology domain-containing family H member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010807869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807869" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF01", "url": "https://www.uniprot.org/uniprotkb/E1BF01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHH1", "url": "https://www.uniprot.org/uniprotkb/E1BF01", "locus": { "chromosome": "10", "start_pos": 79464977, "end_pos": 79408161, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018297", "url": "https://www.ensembl.org/id/ENSBTAG00000018297" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018297", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13206", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13206", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13282", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13282", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515305", "url": "https://www.ncbi.nlm.nih.gov/gene/515305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYPIRYR", "url": "https://omabrowser.org/oma/group/FYPIRYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF01", "url": "https://www.orthodb.org/?gene=E1BF01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22903:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22903:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010807869", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807869", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF01", "url": "https://www.uniprot.org/uniprotkb/E1BF01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF01-1", "url": "https://www.uniprot.org/uniprotkb/E1BF01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELTVETRASVDWQKRCLALETQLFRFRLQASKIRELLADKMQELEQRLLDAEQRAENAETQVGVMEEKVKLSNLMNVDSAGSLHRKYQELLKAMQGKDELISELEAQLEKQKQMRAEEAKVVQEKAAKIKEWVTLKLAELEMENQHLKSCNQHLVEQVGALQRAVEALQMSPSGKLLVAPQGTTEQESVPSGPGTQPAGQDSGPLAQGALKAAIPAPSPGALQSKDSVPKAGSPMEDSSSQTVHPGATSEAKTLPLHLGRQGSPGQLCLRPRTPRHALASWGEGLVTAQGGTLPRTKTSAKEGGPGCSLTLPKARAPSTLRDSIQLAKRHHSQPQAGPGHFSHVVRIEVGTLSAFHPHSLPKGVVRAKLREEPEKMEMEEQPPVGEKEAQGTELEEVDLENKPPTPPLHRFPSWESRIYAVATSGMRLSEVPVRSNATCCASSPPALASPGPFSGLVYKNVAVPVYTALKGKATQISTVPFVDESSGSDDDCSSQASFRTSLPCSESRKTSGLGSPRAIKRGVSVSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGPGGESLEKSGYLLKMGSRVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVELNSRCQIVRGEGAQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQAIGPPALPQGGTKPTVKGWLTKVKHGHSKLVWCALVGRTFYYYRSHEDKRPLGRLPVRDARIEEVDRSCDSDEDYEAGGTRRLLSSHYTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYTSLTTLPSEALQTEAVKLFKASLSQPQRTVVKEPPEPAVVSLQSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQISCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRNETGQYATYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKSSHSGFALFTDDPAGRDLEHCLQGSVKICDAISKWEQALKELHTGKSEGGTRVVKLIYKNRLYFRSQVKGETERERLLLASQTNGEIVAGRFPVNKELALEMAALMAQVEYGDLERPILPGPGGTPSAKAQHHLQQVLDRFYPRRYRHGAPPEQLRHLADQLTTKWAALQGCSSPECVRIYLTVARKWPLFGAKLFAAQPAQLSSKESALVWIAVNEDGVSILDHNTMQLHVTYPYSSVMTFGGCRDDFMLVIRSVPDQSSGKGHVEKLIFRMAAPKIAEVTLILASYMNHCSTTVNPPSTPAAACQPWELDGRQFFASVPCAAKGPTLL", "length": 1382, "header": "tr|E1BF01-1|E1BF01_BOVIN Isoform 1 of Pleckstrin homology, MyTH4 and FERM domain containing H1 OS=Bos taurus OX=9913 GN=PLEKHH1 PE=4 SV=4 CANONICAL=E1BF01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5R1-1", "url": "https://www.uniprot.org/uniprotkb/E1BF01/entry#A0AAA9S5R1-1", "sequence": { "sequence": "MELPADPANAFPLSQKQMRAEEAKVVQEKAAKIKEWVTLKLAELEMENQHLKSCNQHLVEQVGALQRAVEALQMSPSGKLLVAPQGTTEQESVPSGPGTQPAGQDSGPLAQGALKAAIPAPSPGALQSKDSVPKAGSPMEDSSSQTVHPGATSEAKTLPLHLGRQGSPGQLCLRPRTPRHALASWGEGLVTAQGGTLPRTKTSAKEGGPGCSLTLPKARAPSTLRDSIQLAKRHHSQPQAGPGHFSHVVRIEVGTLSAFHPHSLPKGVVRAKLREEPEKMEMEEQPPVGEKEAQGTELEEVDLENKPPTPPLHRFPSWESRIYAVATSGMRLSEVPVRSNATCCASSPPALASPGPFSGLVYKNVAVPVYTALKGKATQISTVPFVDESSGSDDDCSSQASFRTSLPCSESRKTSGLGSPRAIKRGVSVSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGPGGESLEKSGYLLKMGSRVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVELNSRCQIVRGEGAQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQAIGPPALPQGGTKPTVKGWLTKVKHGHSKLVWCALVGRTFYYYRSHEDKRPLGRLPVRDARIEEVDRSCDSDEDYEAGGTRRLLSSHYTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYTSLTTLPSEALQTEAVKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQISCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRNETGQYATYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKSSHSGFALFTDDPAGRDLEHCLQGSVKICDAISKWEQALKELHTGKSEGGTRVVKLIYKNRLYFRSQVKGETERERLLLASQTNGEIVAGRFPVNKELALEMAALMAQVEYGDLERPILPGPGGTPSAKAQHHLQQVLDRFYPRRYRHGAPPEQLRHLADQLTTKWAALQGCSSPECVRIYLTVARKWPLFGAKLFAAQPAQLSSKESALVWIAVNEDGVSILDHNTMQLHVTYPYSSVMTFGGCRDDFMLVIRSVPDQSSGKGHVEKLIFRMAAPKIAEVTLILASYMNHCSTTVNPPSTPAAACQPWELDGRQFFASVPCAAKGPTLL", "length": 1261, "header": "tr|A0AAA9S5R1-1|A0AAA9S5R1_BOVIN Computationally mapped isoform of Pleckstrin homology, MyTH4 and FERM domain containing H1 OS=Bos taurus OX=9913 GN=PLEKHH1 PE=4 SV=1 CANONICAL=E1BF01-1" }, "locus": { "chromosome": "10", "start_pos": 79463973, "end_pos": 79436604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112200.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112200.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079180.1" } ] } }, { "isoform_ac": "E1BF01-1", "url": "https://www.uniprot.org/uniprotkb/E1BF01/entry#E1BF01-1", "sequence": { "sequence": "MAELTVETRASVDWQKRCLALETQLFRFRLQASKIRELLADKMQELEQRLLDAEQRAENAETQVGVMEEKVKLSNLMNVDSAGSLHRKYQELLKAMQGKDELISELEAQLEKQKQMRAEEAKVVQEKAAKIKEWVTLKLAELEMENQHLKSCNQHLVEQVGALQRAVEALQMSPSGKLLVAPQGTTEQESVPSGPGTQPAGQDSGPLAQGALKAAIPAPSPGALQSKDSVPKAGSPMEDSSSQTVHPGATSEAKTLPLHLGRQGSPGQLCLRPRTPRHALASWGEGLVTAQGGTLPRTKTSAKEGGPGCSLTLPKARAPSTLRDSIQLAKRHHSQPQAGPGHFSHVVRIEVGTLSAFHPHSLPKGVVRAKLREEPEKMEMEEQPPVGEKEAQGTELEEVDLENKPPTPPLHRFPSWESRIYAVATSGMRLSEVPVRSNATCCASSPPALASPGPFSGLVYKNVAVPVYTALKGKATQISTVPFVDESSGSDDDCSSQASFRTSLPCSESRKTSGLGSPRAIKRGVSVSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGPGGESLEKSGYLLKMGSRVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVELNSRCQIVRGEGAQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQAIGPPALPQGGTKPTVKGWLTKVKHGHSKLVWCALVGRTFYYYRSHEDKRPLGRLPVRDARIEEVDRSCDSDEDYEAGGTRRLLSSHYTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYTSLTTLPSEALQTEAVKLFKASLSQPQRTVVKEPPEPAVVSLQSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQISCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRNETGQYATYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKSSHSGFALFTDDPAGRDLEHCLQGSVKICDAISKWEQALKELHTGKSEGGTRVVKLIYKNRLYFRSQVKGETERERLLLASQTNGEIVAGRFPVNKELALEMAALMAQVEYGDLERPILPGPGGTPSAKAQHHLQQVLDRFYPRRYRHGAPPEQLRHLADQLTTKWAALQGCSSPECVRIYLTVARKWPLFGAKLFAAQPAQLSSKESALVWIAVNEDGVSILDHNTMQLHVTYPYSSVMTFGGCRDDFMLVIRSVPDQSSGKGHVEKLIFRMAAPKIAEVTLILASYMNHCSTTVNPPSTPAAACQPWELDGRQFFASVPCAAKGPTLL", "length": 1382, "header": "tr|E1BF01-1|E1BF01_BOVIN Isoform 1 of Pleckstrin homology, MyTH4 and FERM domain containing H1 OS=Bos taurus OX=9913 GN=PLEKHH1 PE=4 SV=4 CANONICAL=E1BF01-1" }, "locus": { "chromosome": "10", "start_pos": 79463973, "end_pos": 79421001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024351.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024351.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024351.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024351.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1177, "start_aa": "Thr", "end_pos": 1177, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1177", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1353, "start_aa": "Thr", "end_pos": 1353, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1353", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 407, "start_aa": "Thr", "end_pos": 407, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr407", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AA54-1", "protein_name": "Pleckstrin homology, MyTH4 and FERM domain containing H1", "gene_name": "Plekhh1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEVKVEVVGIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKIKLSNLKSVDSTGSLHQKYQELLKAMQGKDELIGQLQAQLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELEMENQHLKTCNQQLVEQVAALQDALEDLRMTPSEELLGVPEGTPEGDPVPSGPSAQPVEQDSNPNTQISKVAVPTPLGTLQSKDFLSEARSPEDLSFSMAHPGDIAEAKTLQSHLQREGSPSQPFMKPGSPRCGSASYREGLITAQGGTFPGTKISAREGGPGSSLTLPKVRAPSIPRDSFQVAKRHHSQPQVGPGHVDHVVSIEIGALSALHSSGLPKSEARAKVREEAEKMEMEELPPMGKKGERESLKPRRGELEGVEPENKPPTPPLHRFPSWERRIYAMATSGMQLSDVSSRNTASCFASGPPALAFPGAFSGLIYKNVTVPVYTALKGKATQISNVPFVDESSGSDDDCGSQASFRMSVPCSEYRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSAYSTDGETLEKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPNDVIRKPQGQVDLNSHCQIVRGEEAQTFQLISGNKIYYLTAESPSLLEEWIRVLQSLLKVQVTGPPALHQGGTKPTVKGWLTKVKHGHSKLVWCALVGKTFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTVYEQLIGKLMDGEGNPDSPLWRHPMLCYSQEGLCASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQISRRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYAIYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTDDPSGRDLEHCLQGRVKICDAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQTSGEIVAGRFPVTKELALEMAALMAQVEYGDLEKPTLPGPGGTPPAKAQHLLQQVLDRFYPRHYRNGAPPEQLRHLADMMATKWAALQGCSPPECIRIYLTVARKWPLFGAKLFAAQPAQPLSSKENTPVWIAVNEDGVSILDQRTMQVNITYPYSSVTTFGGCRDDFMLVIRSIPDQNSGKTRIDKLTFRMPAPKITDTTLVMASYMNHCSATVNLSAKLPAARQPRDLDGQFFASVSCTKGSALL", "length": 1355 }, "evidence": [ { "id": "E1BF01", "url": "https://omabrowser.org/oma/group/E1BF01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H1M0-1", "protein_name": "Pleckstrin homology domain-containing family H member 1 isoform X1", "gene_name": "Plekhh1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEVKVEVASIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKIKLSNLKNGDSTGSLHQKYQELLKAMQSKDELISQLEAQLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELETENEHLKAYNQQLVEQVEALRDTLADLRMTPSEKLLVVPEGTPEGNPVPSGPRTQPVEQDSNTHTQILKVAVPAPSLGTLQNKDSMSEARSLEDLSSSMVYSGEIAEAKTLKSHPQREGSPSQLLEKPGSRKHVSASYRANLLTAPGGTFPGTKISSREGGPGSSLTLPKVRAPSNPRDSFQLAKRHHSQPQVGPGHFDHVVNIKIGALPALPLSGFSKSESRAKAREEAEKMEMEEPLPTGKQEERESLKPPRAALEEVELEKKPPTPPLHRFPSWESRIYAMATSGMQLSDVSSQSDAAWCASGPPALAFPGAFSGLVYKNVTVPVYTALKGKATQISNVPFVDESSGSDDDCSSQASFRMSVPCSEYRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGEALEKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRKPQGQVDLNSHCQIVRGEGAQTFQLISENKTYYLTAESPSLLEEWIRVLQSLLKVQVIGPPALHQGGAKPTVKGWLTKVKHGHSKLVWCALVGKTFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTVYEQLIGKLMDGEGDPDSPLWRHPMLCYSRDGLCNSLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRNETGQYATYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTDDPSGRDLEHCLQGRVKICDAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQTSGEIVAGRFPVTKELALEMAALMAQVEYGDLEKPVLPGPGGTPPAKAQHLLQQILDRFYPKRYRNGAHPEQLRHLADTMATKWAALQGCSPSECIRIYLTVARKWPLFGAKLFAAQPAQLSSKENTLVWIAVNEDGVSILDHHTMQVHITYPYSSVTTFGGCKDDFMLVIRSIPDQSSGKTHIDKLIFKMPAPKITETTFMMASYMNHCSATVNLSSKLPAARQPRDLDGQFFASASCTKGPALL", "length": 1355 }, "evidence": [ { "id": "E1BF01", "url": "https://omabrowser.org/oma/group/E1BF01/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q80TI1-1", "protein_name": "Pleckstrin homology domain-containing family H member 1", "gene_name": "Plekhh1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEVKVEVASIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKIKLSNLKSVDSTGTLHQKYQELLRAVQGKDELISQLQAQLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELEMENQQLKTCNQQLVEQVAALQDALEDLRMTPSEELLVVPEGTPERDPVPSGPSDQPVEQDSNPHTQILKVAVPTPSLGTLQSRDSLSEARSLEDLRFSMVHPGETAEAKTLQSHLQKEGSPSQLCMKPGNPKHGSASYRESLVTAQGGTFPGTKTSAREGGPGSSLTLPKVRAPSIPRDSFQVAKRHHSQPQVGPGHCDHVVSIEIGALSALHSPGSSKSEARAKVREEAEKMEMEALPPSGKQEERESLKSRRGELEDVELENKPPTPPLHRFPSWESRIYAMATSGMQLSEVSSRRSNAACYASGPSALAFPGAFSGLVYKNVTVPVYTALKGKATQISNVPFVDESSGSDDDCGSQASFRMSVPCSEYRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGEALEKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRKPQGQVDLNSHCQIVREEEAQTFQLISGNKTYYLTAESPSLLEEWIRVLQSLLKVQVTGPPALHQGGTKPTVKGWLTKVKHGHSKLVWCALVGKTFYYYRSHEDKRPLGCLPVQDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSNAKVGTVYEQLIGKLMDGEGNPDSPLWRHPMLCYSQEGLCASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQISCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYAIYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTDDPSGRDLEHCLQGRVKICDAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQASGEIVAGRFPVTKELALEMAALMAQVEYGDLEKPTLPGPGGTPPTKAQHLLQQVLDRFYPRRYRNGAPPEQLRHLADMMATKWAALQGCSPPECIRIYLTVARKWPLFGAKLFAAQPAQLSPKENTVVWIAVNEDGVSILDHRTMQVNITYPYSSVTTFGGCRDDFMLVIRSIPDQSSGKTRIDKLTFRMPAPKITETTLMMASYMNHCSATVNLSAKLPAARQPRDLDGQFFASVSCTKGSALL", "length": 1356 }, "evidence": [ { "id": "E1BF01", "url": "https://omabrowser.org/oma/group/E1BF01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULM0-1", "protein_name": "Pleckstrin homology domain-containing family H member 1", "gene_name": "PLEKHH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMASYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL", "length": 1364 }, "evidence": [ { "id": "E1BF01", "url": "https://omabrowser.org/oma/group/E1BF01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W5D0-1", "protein_name": "Uncharacterized protein CG43867", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQWTAASCDQHDQHDPPAVNRNSIEQRTPANNCEVDPMDATGSTKHPHLPKQREADRPVSGSGGGSSSLTLSGAVTTSMEVTVSTTTTTTIIESSSSTNTTLEKNSPSPAGGSCSSGSGSLSPAYLQHHLQHHGSPLHHLQVHHHTAPPSPLAAVRSAQMGSSVANGAGPAAACLAVCCSPGSSHHHLGHVGHLATGHPLPHQLPHQLPHPSLYPLMAAAQLGYAGSSGPSSLVNSPALGRRKRYTSNSSNCSSQFNNNYAGLDVDSLDDMLRKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPKPPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLEIQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKNHIANQSQRHSIVGPVRNSLSLDVQDFTGSGSNPEHRRRSESLDPQEIIGRPLTSSYPHHQHRRNLSMEPQELERNLVAAVDGLTLAPLSSISNKAPGGVPTESGVVTRPDSSDTDTAHDYAEIYTPSCEKLPAWMKNNPALMASGGNSSTTTTTTSELGVPRPPTPPLHRFPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQTASGGFCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSSRINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVISDLSFESGLSDDYALPPDAVSESTCMDASMPSLLMRQSYVDSPSKKIESLEKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHATMDDWIRVLQNVQRRNATKLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQINMRDARVEEVEHVSDSDSEEREDAAQDQARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVSGGGPSAGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTRDATNGFCLFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVGVGLKGLDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQSPESNTASGATPVAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVVSHDDGGGGEQKLLFAMSKPKILEITLLIADYMNALGHTVPGTPQMNSLTRNGSHRSLRTSQRPNLGGGSAVATGFSTNATTTAHNTLNSHATHTLNSNHSHTLSSSHHAGGGSQPGTLSSGHHQHHHIQQHHQPDILKSTPDHQRIK", "length": 1820 }, "evidence": [ { "id": "E1BF01", "url": "https://omabrowser.org/oma/group/E1BF01/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BF01", "url": "https://www.uniprot.org/uniprotkb/E1BF01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1023, "end_pos": 1025, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 969, "end_pos": 971, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF01" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 1015, "end_pos": 1349, "start_aa": "Phe", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BF01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF01" }, { "id": "PS51016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MyTH4", "eco_id": "ECO_0000259", "start_pos": 827, "end_pos": 1004, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BF01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF01" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 573, "end_pos": 667, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 407, 1177, 1353 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1023, "end_pos": 1025 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 969, "end_pos": 971 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF06-1", "uniprot_ac": "E1BF06", "uniprot_id": "E1BF06_BOVIN", "mass": { "chemical_mass": 28518.0, "monoisotopic_mass": 28518.0 }, "refseq": { "ac": "NP_001192711", "name": "tumor necrosis factor ligand superfamily member 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" }, "gene_names": [ { "name": "TNFSF15", "type": "recommended", "evidence": [ { "id": "E1BF06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ] }, { "name": "TNFSF15", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] }, { "name": "TNLG1B", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] } ], "protein_names": [ { "name": "Tumor necrosis factor ligand superfamily member 15", "type": "recommended", "evidence": [ { "id": "E1BF06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF06/entry#names_and_taxonomy" } ] }, { "name": "TNF ligand-related molecule 1", "type": "synonym", "evidence": [ { "id": "E1BF06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF06/entry#names_and_taxonomy" } ] }, { "name": "Vascular endothelial cell growth inhibitor", "type": "synonym", "evidence": [ { "id": "E1BF06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF06/entry#names_and_taxonomy" } ] }, { "name": "tumor necrosis factor (ligand) superfamily, member 15", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] }, { "name": "tumor necrosis factor ligand 1B", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] }, { "name": "tumor necrosis factor ligand superfamily member 15", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] }, { "name": "tumor necrosis factor superfamily member 15", "type": "synonym", "evidence": [ { "id": "NP_001192711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFSF15", "url": "https://www.uniprot.org/uniprotkb/E1BF06", "locus": { "chromosome": "8", "start_pos": 103968196, "end_pos": 103989086, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018069", "url": "https://www.ensembl.org/id/ENSBTAG00000018069" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018069", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018069", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00184", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00184", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514239", "url": "https://www.ncbi.nlm.nih.gov/gene/514239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514239", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514239", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EACVFQT", "url": "https://omabrowser.org/oma/group/EACVFQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF06", "url": "https://www.orthodb.org/?gene=E1BF06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11471", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11471", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11471:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11471:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192711", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF06-1", "url": "https://www.uniprot.org/uniprotkb/E1BF06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAESLTLGFRETASVEMLPEDGGCRPKARAGLASRRSSAHWPLTCCLLSIPILAALTTYLLVGQLRAQGEACELRTPKEQEIGPSHQRAYAPPGADREKPRAHLTVVRQTPMQPLKNQFPALHWEHELGLAFTKNRMNYTNKFLVIPESGDYFVYSQVTFRGTTSECGEISQGRRPNKPDSIIVVITKVTDSYPEPTQLLMGTKSVCEIGSNWFQPIYLGAMFSLNEGDKLMVNVSDISLVDYTKEDKTFFGAFLL", "length": 256, "header": "tr|E1BF06-1|E1BF06_BOVIN Isoform 1 of Tumor necrosis factor ligand superfamily member 15 OS=Bos taurus OX=9913 GN=TNFSF15 PE=3 SV=1 CANONICAL=E1BF06-1" }, "isoforms": [ { "isoform_ac": "E1BF06-1", "url": "https://www.uniprot.org/uniprotkb/E1BF06/entry#E1BF06-1", "sequence": { "sequence": "MAESLTLGFRETASVEMLPEDGGCRPKARAGLASRRSSAHWPLTCCLLSIPILAALTTYLLVGQLRAQGEACELRTPKEQEIGPSHQRAYAPPGADREKPRAHLTVVRQTPMQPLKNQFPALHWEHELGLAFTKNRMNYTNKFLVIPESGDYFVYSQVTFRGTTSECGEISQGRRPNKPDSIIVVITKVTDSYPEPTQLLMGTKSVCEIGSNWFQPIYLGAMFSLNEGDKLMVNVSDISLVDYTKEDKTFFGAFLL", "length": 256, "header": "tr|E1BF06-1|E1BF06_BOVIN Isoform 1 of Tumor necrosis factor ligand superfamily member 15 OS=Bos taurus OX=9913 GN=TNFSF15 PE=3 SV=1 CANONICAL=E1BF06-1" }, "locus": { "chromosome": "8", "start_pos": 103988664, "end_pos": 103968643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036452.4", "url": "https://www.ensembl.org/id/ENSBTAT00000036452.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036310.2", "url": "https://www.ensembl.org/id/ENSBTAP00000036310.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514239", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514239", "resource": "KEGG Pathway" }, { "id": "R-BTA-5669034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "resource": "Reactome", "description": "TNFs bind their physiological receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061II80-1", "protein_name": "Tumor necrosis factor ligand superfamily member 15", "gene_name": "Tnfsf15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTEELGLGFEEAARVEMPEARARLAASNKTCLAVICCLLSFSILAGLSTFLMRGQLQAPGKDCALRAIQEQNLETSPQPVYTPSRAKPRAHLTILKQTPAPQMKNQFPALHWEHELGLAFTKNRMNYTNKFLVIPESGDYFIYSQITFRGLKSRCGDTSQWRQPSRPDSIVVVITKVTDNYPEPAHLLTGTKSVCEISNNWFQPLYLGAMFSLEEGDRLMVNVSDISLVDYTKEDKTFFGAFLL", "length": 244 }, "evidence": [ { "id": "E1BF06", "url": "https://omabrowser.org/oma/group/E1BF06/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95150-1", "protein_name": "Tumor necrosis factor ligand superfamily member 15", "gene_name": "TNFSF15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL", "length": 251 }, "evidence": [ { "id": "E1BF06", "url": "https://omabrowser.org/oma/group/E1BF06/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "E1BF06", "url": "https://www.uniprot.org/uniprotkb/E1BF06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF06" }, { "id": "PS50049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THD", "eco_id": "ECO_0000259", "start_pos": 100, "end_pos": 256, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF11-1", "uniprot_ac": "E1BF11", "uniprot_id": "E1BF11_BOVIN", "mass": { "chemical_mass": 26809.0, "monoisotopic_mass": 26809.0 }, "refseq": { "ac": "XP_015315794", "name": "complement C1q tumor necrosis factor-related protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315794" }, "gene_names": [ { "name": "C1QTNF8", "type": "recommended", "evidence": [ { "id": "E1BF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF11" } ] }, { "name": "C1QTNF8", "type": "synonym", "evidence": [ { "id": "XP_015315794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315794" } ] } ], "protein_names": [ { "name": "C1q and TNF related 8", "type": "synonym", "evidence": [ { "id": "E1BF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF11/entry#names_and_taxonomy" } ] }, { "name": "complement C1q tumor necrosis factor-related protein 8", "type": "synonym", "evidence": [ { "id": "XP_015315794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315794" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF11", "url": "https://www.uniprot.org/uniprotkb/E1BF11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1QTNF8", "url": "https://www.uniprot.org/uniprotkb/E1BF11", "locus": { "chromosome": "25", "start_pos": 866917, "end_pos": 868276, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033481", "url": "https://www.ensembl.org/id/ENSBTAG00000033481" } ] } } ], "crossref": [ { "id": "ENSBTAG00000033481", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524646", "url": "https://www.ncbi.nlm.nih.gov/gene/524646", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524646", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524646", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVWVRMF", "url": "https://omabrowser.org/oma/group/TVWVRMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF11", "url": "https://www.orthodb.org/?gene=E1BF11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015315794", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315794", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF11", "url": "https://www.uniprot.org/uniprotkb/E1BF11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF11-1", "url": "https://www.uniprot.org/uniprotkb/E1BF11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAPALLLLLALPAGAWRGLGLPRRPCVQCCHPAWPPAAPGPGAHVSDGDAWAGLPRLRPTIDISILKGEKGEAGVRGRSGRSGKEGPPGSRGLRGRKGQKGQAGLPGAQCPRAYAAFSVGRREGLHSADALQAVTFDTELVNLDGAFDLASGRFFCTAPGVYFLSLNVHTWNYKETYLHIMRNARAAAVLYAQPSERSVMQAQSLLLPLAAGDAVWVRMFQRDRDNAIFGESGDLYITFSGHLVKPDAEL", "length": 251, "header": "tr|E1BF11-1|E1BF11_BOVIN Isoform 1 of C1q and TNF related 8 OS=Bos taurus OX=9913 GN=C1QTNF8 PE=4 SV=1 CANONICAL=E1BF11-1" }, "isoforms": [ { "isoform_ac": "E1BF11-1", "url": "https://www.uniprot.org/uniprotkb/E1BF11/entry#E1BF11-1", "sequence": { "sequence": "MVAPALLLLLALPAGAWRGLGLPRRPCVQCCHPAWPPAAPGPGAHVSDGDAWAGLPRLRPTIDISILKGEKGEAGVRGRSGRSGKEGPPGSRGLRGRKGQKGQAGLPGAQCPRAYAAFSVGRREGLHSADALQAVTFDTELVNLDGAFDLASGRFFCTAPGVYFLSLNVHTWNYKETYLHIMRNARAAAVLYAQPSERSVMQAQSLLLPLAAGDAVWVRMFQRDRDNAIFGESGDLYITFSGHLVKPDAEL", "length": 251, "header": "tr|E1BF11-1|E1BF11_BOVIN Isoform 1 of C1q and TNF related 8 OS=Bos taurus OX=9913 GN=C1QTNF8 PE=4 SV=1 CANONICAL=E1BF11-1" }, "locus": { "chromosome": "25", "start_pos": 868276, "end_pos": 866920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016731.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016731.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016731.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016731.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524646", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524646", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BJV8-1", "protein_name": "C1q and TNF related 8", "gene_name": "C1QTNF8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPALLLLLVLPVGAWPGLGLPRRPCMHCCRPAWPPAAPGPHVRSIDGDEWGRLPRVRPTIDIAILKGEKGEAGVRGHSGRSGKEGPPGSRGLQGRKGQKGQAGPPGAPCQRVYAAFSVGRREGLHSADALQAVPFDTELVNLDSTFDLASGRFLCAVPGVYFLSLTVHTWNYKETYLHIMCNRQAVAVLYAQPNERSVMQTQSLLLPLAAGDAVWVRMFQRDRDNAIYGERGDLYITFSGHLVKPDAKL", "length": 251 }, "evidence": [ { "id": "E1BF11", "url": "https://omabrowser.org/oma/group/E1BF11/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P60827-1", "protein_name": "Complement C1q tumor necrosis factor-related protein 8", "gene_name": "C1QTNF8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPALLLLALLLPVGAWPGLPRRPCVHCCRPAWPPGPYARVSDRDLWRGDLWRGLPRVRPTIDIEILKGEKGEAGVRGRAGRSGKEGPPGARGLQGRRGQKGQVGPPGAACRRAYAAFSVGRREGLHSSDHFQAVPFDTELVNLDGAFDLAAGRFLCTVPGVYFLSLNVHTWNYKETYLHIMLNRRPAAVLYAQPSERSVMQAQSLMLLLAAGDAVWVRMFQRDRDNAIYGEHGDLYITFSGHLVKPAAEL", "length": 252 }, "evidence": [ { "id": "E1BF11", "url": "https://omabrowser.org/oma/group/E1BF11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BF11", "url": "https://www.uniprot.org/uniprotkb/E1BF11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of cell motility", "id": "GO:2000147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000147", "evidence": [ { "database": "UniProtKB", "id": "E1BF11", "url": "https://www.uniprot.org/uniprotkb/E1BF11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF11" }, { "id": "PS50871", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50871" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 251, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF12-1", "uniprot_ac": "E1BF12", "uniprot_id": "E1BF12_BOVIN", "mass": { "chemical_mass": 24705.0, "monoisotopic_mass": 24705.0 }, "refseq": {}, "gene_names": [ { "name": "EMC9", "type": "recommended", "evidence": [ { "id": "E1BF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 9", "type": "synonym", "evidence": [ { "id": "E1BF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF12/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC9", "url": "https://www.uniprot.org/uniprotkb/E1BF12", "locus": { "chromosome": "10", "start_pos": 21014209, "end_pos": 21010402, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025778", "url": "https://www.ensembl.org/id/ENSBTAG00000025778" } ] } } ], "crossref": [ { "id": "E1BF12", "url": "https://alphafold.ebi.ac.uk/entry/E1BF12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025778", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025778", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08060", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08060", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BF12", "url": "https://www.orthodb.org/?gene=E1BF12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12941", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12941", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12941:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12941:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03665", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03665", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TUD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF12-1", "url": "https://www.uniprot.org/uniprotkb/E1BF12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEVEISARAYVKMSLHAARYPHAAVNGLLLAPAPAPRSGECLCLTDCVPLFHSHLALSVMLEVALNQVDVWGAQAGLVVAGYYHANAALDDQSPGPLALKIAGRIAEFFPDAVLIMLDNQKLVPQPHVPPVIVLENHGLRWVPKDKNLVMWRDWEESRQMVGALLEGRAHQHLVDFDCHLDDIREDWTNQQLNAQITQWPAGSGSGCGKLPRPTPASSRKHCGSP", "length": 226, "header": "tr|E1BF12-1|E1BF12_BOVIN Isoform 1 of ER membrane protein complex subunit 9 OS=Bos taurus OX=9913 GN=EMC9 PE=3 SV=2 CANONICAL=E1BF12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUD2-1", "url": "https://www.uniprot.org/uniprotkb/E1BF12/entry#A0AAA9TUD2-1", "sequence": { "sequence": "MGEVEISARAYVKMSLHAARYPHAAVNGLLLAPAPAPRSGECLCLTDCVPLFHSHLALSVMLEVALNQVDVWGAQAGLVVAGYYHANAALDDQSPGPLALKIAGRIAEFFPDAVLIMLDNQKLVPQPHVPPVIVLENHGLRWVPKDKNFLQGQGVGVESCLGPPPPPHVSIADLHDHQPDIPVLCLIQLVYQLPIITLWETWIRPDFKGVPPPLHPD", "length": 217, "header": "tr|A0AAA9TUD2-1|A0AAA9TUD2_BOVIN Computationally mapped isoform of ER membrane protein complex subunit 9 OS=Bos taurus OX=9913 GN=EMC9 PE=3 SV=1 CANONICAL=E1BF12-1" }, "locus": { "chromosome": "10", "start_pos": 21013261, "end_pos": 21010601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125466.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125466.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102220.1" } ] } }, { "isoform_ac": "E1BF12-1", "url": "https://www.uniprot.org/uniprotkb/E1BF12/entry#E1BF12-1", "sequence": { "sequence": "MGEVEISARAYVKMSLHAARYPHAAVNGLLLAPAPAPRSGECLCLTDCVPLFHSHLALSVMLEVALNQVDVWGAQAGLVVAGYYHANAALDDQSPGPLALKIAGRIAEFFPDAVLIMLDNQKLVPQPHVPPVIVLENHGLRWVPKDKNLVMWRDWEESRQMVGALLEGRAHQHLVDFDCHLDDIREDWTNQQLNAQITQWPAGSGSGCGKLPRPTPASSRKHCGSP", "length": 226, "header": "tr|E1BF12-1|E1BF12_BOVIN Isoform 1 of ER membrane protein complex subunit 9 OS=Bos taurus OX=9913 GN=EMC9 PE=3 SV=2 CANONICAL=E1BF12-1" }, "locus": { "chromosome": "10", "start_pos": 21013134, "end_pos": 21010601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036447.7", "url": "https://www.ensembl.org/id/ENSBTAT00000036447.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036305.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036305.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 215, "start_aa": "Thr", "end_pos": 215, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr215", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "E1BF12", "url": "https://www.uniprot.org/uniprotkb/E1BF12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF12" }, { "id": "PS50249", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50249" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MPN", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 141, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 215 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF13-1", "uniprot_ac": "E1BF13", "uniprot_id": "E1BF13_BOVIN", "mass": { "chemical_mass": 67915.0, "monoisotopic_mass": 67915.0 }, "refseq": { "ac": "XP_005225972", "name": "kelch repeat and BTB domain-containing protein 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225972" }, "gene_names": [ { "name": "KBTBD11", "type": "recommended", "evidence": [ { "id": "E1BF13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF13" } ] }, { "name": "KBTBD11", "type": "synonym", "evidence": [ { "id": "XP_005225972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225972" } ] } ], "protein_names": [ { "name": "Kelch repeat and BTB domain containing 11", "type": "synonym", "evidence": [ { "id": "E1BF13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF13/entry#names_and_taxonomy" } ] }, { "name": "kelch repeat and BTB domain-containing protein 11", "type": "synonym", "evidence": [ { "id": "XP_005225972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225972" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF13", "url": "https://www.uniprot.org/uniprotkb/E1BF13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KBTBD11", "url": "https://www.uniprot.org/uniprotkb/E1BF13", "locus": { "chromosome": "27", "start_pos": 1435394, "end_pos": 1414045, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060779", "url": "https://www.ensembl.org/id/ENSBTAG00000060779" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518907", "url": "https://www.ncbi.nlm.nih.gov/gene/518907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HAVAPCV", "url": "https://omabrowser.org/oma/group/HAVAPCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF13", "url": "https://www.orthodb.org/?gene=E1BF13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45972:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45972:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225972", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225972", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF13", "url": "https://www.uniprot.org/uniprotkb/E1BF13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF13-1", "url": "https://www.uniprot.org/uniprotkb/E1BF13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENPVVPCVLYPGDGACGQAGGRGGAPEAPGEGSLQPPDAAEGEGAASPAQTPCSLSASLCFSSGDDSPPQSRASSAAEDAAASPPSCCSGRRVVERQWGVGSSGAASPEDSASPEEPAFPGERPPTEEPTSPEEHADPAPVPPGVGPEHGEPDLLIEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVGWAALRLLLAYAYSGRMAGVRPDNVADVVAGARRLQLPCAAQRATDAVAPQLSLANCFEVLSAAKRQRLAELREAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRTRLLAAALGPAGERAGSRPQSPSGDAEGRGEAAVYCFHEAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVGPAGPDGRARPSDRVFCYNPATDRWSTVRPLRQARSQLQLLALDGHLYAVGGECLLSVERYDPRADRWAAVAPLPRGAFAVAHEATTCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLCGARGDAPAAVPAGGVSVLRYHCLAKQWSRCASHLRPPGAPSGLQPFRCAALEGTIYCVSRAGTWRFVPPGEGEPGAGDAGLEGSFELQSLQTPADARGLLFPFVLNLPEEKPDRGEEGAV", "length": 641, "header": "tr|E1BF13-1|E1BF13_BOVIN Isoform 1 of Kelch repeat and BTB domain containing 11 OS=Bos taurus OX=9913 GN=KBTBD11 PE=4 SV=3 CANONICAL=E1BF13-1" }, "isoforms": [ { "isoform_ac": "E1BF13-1", "url": "https://www.uniprot.org/uniprotkb/E1BF13/entry#E1BF13-1", "sequence": { "sequence": "MENPVVPCVLYPGDGACGQAGGRGGAPEAPGEGSLQPPDAAEGEGAASPAQTPCSLSASLCFSSGDDSPPQSRASSAAEDAAASPPSCCSGRRVVERQWGVGSSGAASPEDSASPEEPAFPGERPPTEEPTSPEEHADPAPVPPGVGPEHGEPDLLIEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVGWAALRLLLAYAYSGRMAGVRPDNVADVVAGARRLQLPCAAQRATDAVAPQLSLANCFEVLSAAKRQRLAELREAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRTRLLAAALGPAGERAGSRPQSPSGDAEGRGEAAVYCFHEAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVGPAGPDGRARPSDRVFCYNPATDRWSTVRPLRQARSQLQLLALDGHLYAVGGECLLSVERYDPRADRWAAVAPLPRGAFAVAHEATTCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLCGARGDAPAAVPAGGVSVLRYHCLAKQWSRCASHLRPPGAPSGLQPFRCAALEGTIYCVSRAGTWRFVPPGEGEPGAGDAGLEGSFELQSLQTPADARGLLFPFVLNLPEEKPDRGEEGAV", "length": 641, "header": "tr|E1BF13-1|E1BF13_BOVIN Isoform 1 of Kelch repeat and BTB domain containing 11 OS=Bos taurus OX=9913 GN=KBTBD11 PE=4 SV=3 CANONICAL=E1BF13-1" }, "locus": { "chromosome": "27", "start_pos": 1431107, "end_pos": 1429185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080693.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518907", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X7H5-1", "protein_name": "Kelch repeat and BTB domain containing 11", "gene_name": "KBTBD11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGSGTVEEEESGAGSGAPPLTLSSPCSFSSSLCFSSATSEQGAPSPSSTGSHVVESQWELNSVASESEEEEASAREPSAGAQPTGRPAEEPDLVIEVSGQRIRAHKSVLAAKSDYFRARASRDILRVKGVSYGALRLLIDYVYTARMGEVRHDNLAEVVSGARVLQMPCALHCAAEAMRAQLRLDNCYQLLCLAKKQRLAELREAAYRFMSDHYLEVLREPGVYGRLSGAERDLILQRRLEAGRRCLLVAEVSDAFERPGGGSRPQSRESSRPQSPSSVMSLEESGSLIHCYHEASHEWRVLTRLPEEANAKGCAMCVLHNYLFLAGGIAAGPAGSEPRARLSDKVFCYNPLTDTWSQVRPLAQPRSQLKLLALDGYLYAVGGECLFTVEKYDPRADRWSPVAPLPKGAFAVAHEATTCNGEIYVSGGSLFYRLLKYDPKRDEWQECPYNSSRRRSADMVAFKNFIYRFDVSSGRGGEQGPGGGTGGGVEVFRYNTVAKRWSQCASLRPSSGPIQPFRCAALGNTIYCVNRTGTLRFNLAQDGEVEADGGLKGTFDGELLKAPFDAKGLLLPFVLTLPEKLEKAGDQESSLSL", "length": 594 }, "evidence": [ { "id": "E1BF13", "url": "https://omabrowser.org/oma/group/E1BF13/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A5J1-1", "protein_name": "Kelch repeat and BTB domain containing 11", "gene_name": "Kbtbd11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MENSVAPFVLYPGTEPRTPGEDSLPLPAEEEGAASPAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPQECARPEEPASPEEPPSRREHARPVELESLDELGEPVPVPPGVGSEHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGCMAGVRPDNVAEVVAGARRLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLSELRDAAYRFMCDHYLEVLREPAVFGRLSGAERDLLLRRRLGTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVYCYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFVAGGVAPAGPDGRARPSDQVFCYNPVTDCWSTVRPLRQARSQVQLLALDGHLYALGGECLLSVERYDPRADRWTAVAPLPRGAFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFLYRFDLCGSRGDAQAATGSGGGVSVFRYHCLAKQWSQCAAHLRPPGAPAGLQPFRCVALDGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEKPDRGEQGAA", "length": 633 }, "evidence": [ { "id": "E1BF13", "url": "https://omabrowser.org/oma/group/E1BF13/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O94819-1", "protein_name": "Kelch repeat and BTB domain-containing protein 11", "gene_name": "KBTBD11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP", "length": 623 }, "evidence": [ { "id": "E1BF13", "url": "https://omabrowser.org/oma/group/E1BF13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BNW9-1", "protein_name": "Kelch repeat and BTB domain-containing protein 11", "gene_name": "Kbtbd11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENSVAPFVLYSGTEPRTPGEDSLPLPAEEEGAASTAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPEECARPEEPASPEDPPSRHEHARPVELESLDELGEPVPVPPGVGSVHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLCTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVYCYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFLAGGVAPAGPDGRARPSDQVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYAVGGECLLSVERYDPRADRWTAVAPLPRGAFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFLYRFDLCGSRGEAQAAVGSGGGVSVFRYHCLAKQWSQCAVHLRPPGAPAGLQPFRCVALDGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEKPDRGEQGAV", "length": 633 }, "evidence": [ { "id": "E1BF13", "url": "https://omabrowser.org/oma/group/E1BF13/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF13" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 209, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF22-1", "uniprot_ac": "E1BF22", "uniprot_id": "E1BF22_BOVIN", "mass": { "chemical_mass": 43754.0, "monoisotopic_mass": 43754.0 }, "refseq": { "ac": "NP_001178401", "name": "cyclin-J", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178401" }, "gene_names": [ { "name": "CCNJ", "type": "recommended", "evidence": [ { "id": "E1BF22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ] }, { "name": "CCNJ", "type": "synonym", "evidence": [ { "id": "NP_001178401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178401" } ] } ], "protein_names": [ { "name": "Cyclin-J", "type": "recommended", "evidence": [ { "id": "E1BF22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF22/entry#names_and_taxonomy" } ] }, { "name": "cyclin-J", "type": "synonym", "evidence": [ { "id": "NP_001178401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178401" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNJ", "url": "https://www.uniprot.org/uniprotkb/E1BF22", "locus": { "chromosome": "26", "start_pos": 17429629, "end_pos": 17413419, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033685", "url": "https://www.ensembl.org/id/ENSBTAG00000033685" } ] } } ], "crossref": [ { "id": "E1BF22", "url": "https://alphafold.ebi.ac.uk/entry/E1BF22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033685", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033685", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20529", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20529", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523293", "url": "https://www.ncbi.nlm.nih.gov/gene/523293", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523293", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523293", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FLMQCIE", "url": "https://omabrowser.org/oma/group/FLMQCIE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF22", "url": "https://www.orthodb.org/?gene=E1BF22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02984", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02984", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178401", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAC1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF22-1", "url": "https://www.uniprot.org/uniprotkb/E1BF22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELEAQWWRGQLAADIHQALRYKELKLPSYKGQSPQLSLRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMMCLEKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILRLSPTWPTRLHRLTAYSWDFLVQCIERLLIAHDNDVKEANKQRGQAGPQPAQLSVFQAASQPSRAVHFQQPQYLHQTHQTSLQYRHPVSEQPSCQQIVSTTHTSSYTLPTCPAGFQTSVQGLGHVPAGVGMSLAIPVEVKPCLNVSYNRSYQINEHYPCITQCFER", "length": 383, "header": "tr|E1BF22-1|E1BF22_BOVIN Isoform 1 of Cyclin-J OS=Bos taurus OX=9913 GN=CCNJ PE=3 SV=1 CANONICAL=E1BF22-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NAC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BF22/entry#A0A3Q1NAC1-1", "sequence": { "sequence": "MELEAQWWRGQLAADIHQALRYKELKLPSYKGQSPQLSLRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLAAHFIEYYLSEAVHETDLHDGWPMMCLEKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILRLSPTWPTRLHRLTAYSWDFLVQCIERLLIAHDNDVKEANKQRGQAGPQPAQLSVFQAASQPSRAVHFQQPQYLHQTHQTSLQYRHPVSEQPSCQQIVSTTHTSSYTLPTCPAGFQTSVQGLGHVPAGVGMSLAIPVEVKPCLNVSYNRSYQINEHYPCITQCFER", "length": 349, "header": "tr|A0A3Q1NAC1-1|A0A3Q1NAC1_BOVIN Computationally mapped isoform of Cyclin J OS=Bos taurus OX=9913 GN=CCNJ PE=3 SV=1 CANONICAL=E1BF22-1" }, "locus": { "chromosome": "26", "start_pos": 17428625, "end_pos": 17414265, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068105.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068105.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068186.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068186.2" } ] } }, { "isoform_ac": "E1BF22-1", "url": "https://www.uniprot.org/uniprotkb/E1BF22/entry#E1BF22-1", "sequence": { "sequence": "MELEAQWWRGQLAADIHQALRYKELKLPSYKGQSPQLSLRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMMCLEKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILRLSPTWPTRLHRLTAYSWDFLVQCIERLLIAHDNDVKEANKQRGQAGPQPAQLSVFQAASQPSRAVHFQQPQYLHQTHQTSLQYRHPVSEQPSCQQIVSTTHTSSYTLPTCPAGFQTSVQGLGHVPAGVGMSLAIPVEVKPCLNVSYNRSYQINEHYPCITQCFER", "length": 383, "header": "tr|E1BF22-1|E1BF22_BOVIN Isoform 1 of Cyclin-J OS=Bos taurus OX=9913 GN=CCNJ PE=3 SV=1 CANONICAL=E1BF22-1" }, "locus": { "chromosome": "26", "start_pos": 17428625, "end_pos": 17414265, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004744.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004744.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004744.2", "url": "https://www.ensembl.org/id/ENSBTAP00000004744.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523293", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523293", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C1A2-1", "protein_name": "Cyclin-J", "gene_name": "CCNJ", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELEAQWWTGQLAADIHQALRYKELKLPSYKGQSPQLHLRRYFADLIAIVSNRFRLCPAARHLAVYLLDLFMDRYDISIQQLHVVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIDYYLSIAVHETDLHDGWPMVCLEKTKLYMAKYADYFLEVSLQDHAFLNYAPSLVATACVASSRIILRLSPTWPTRLHHLTAYSWDFLVPCIERLLIAHDNDVKEANKQKGQHAQSAQHTVFQTPGPTAQQANVQPHIPQYLQAHQSSLQYHHQTSQQQNCQQIVSANHTASYPLQTCPAALQSSVQARSHVQTGAAMSLAVPLEVKPCISVSYNRSYQVNGRYSCVTPCFER", "length": 383 }, "evidence": [ { "id": "E1BF22", "url": "https://omabrowser.org/oma/group/E1BF22/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3TZI6-1", "protein_name": "Cyclin-J", "gene_name": "Ccnj", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELEGQWWRGQLAADIHQALRYKELKLPSYKGQSPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVLTKQTLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMVCLEKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILRLSPTWPTRLHRLTAYSWDFLVQCIERLLLAHDNDVKEANKQRGQSAPQSTQLTVFQTAQPSRPVHFQQPQYLHQSSLQYRHPVSEQPSRQQIVSTTHTSSYTLQTCPAGFQTSVQGLGHMQTGVGMSLAIPVEVKPCLSVSYNRSYQINEHFPCITPCFER", "length": 379 }, "evidence": [ { "id": "E1BF22", "url": "https://omabrowser.org/oma/group/E1BF22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T5M9-1", "protein_name": "Cyclin-J", "gene_name": "CCNJ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELEGQWWRGQLAADIHQALRYKELKLPSYKGQSPQLSLRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMICLEKTKLYMAKYADYFLEVSLQVAAACVASSRIILRLSPTWPTRLHRLTAYSWDFLVQCIERLLIAHDNDVKEANKQRGQAGPQSAQLSVFQTASQPSRPVHFQQPQYLHQTHQTSLQYRHPTSEQPSCQQIVSTTHTSSYTLQTCPAGFQTSVQGLGHMQTGVGMSLAIPVEVKPCLSVSYNRSYQINEHYPCITPCFER", "length": 372 }, "evidence": [ { "id": "E1BF22", "url": "https://omabrowser.org/oma/group/E1BF22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "E1BF22", "url": "https://www.uniprot.org/uniprotkb/E1BF22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 383, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF22" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 361, "end_pos": 363 }, { "start_pos": 365, "end_pos": 367 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF30-1", "uniprot_ac": "E1BF30", "uniprot_id": "E1BF30_BOVIN", "mass": { "chemical_mass": 34865.0, "monoisotopic_mass": 34865.0 }, "refseq": { "ac": "NP_001377070", "name": "olfactory receptor family 1 subfamily A member 1D", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070" }, "gene_names": [ { "name": "OR1A1D", "type": "recommended", "evidence": [ { "id": "E1BF30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ] }, { "name": "OR1A1D", "type": "synonym", "evidence": [ { "id": "NP_001377070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 1 subfamily A member 1D", "type": "synonym", "evidence": [ { "id": "E1BF30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF30/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 1 subfamily A member 1D", "type": "synonym", "evidence": [ { "id": "NP_001377070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070" } ] }, { "name": "olfactory receptor, family 1, subfamily A, member 1-like", "type": "synonym", "evidence": [ { "id": "NP_001377070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1A1D", "url": "https://www.uniprot.org/uniprotkb/E1BF30", "locus": { "chromosome": "19", "start_pos": 23935800, "end_pos": 23936738, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061433", "url": "https://www.ensembl.org/id/ENSBTAG00000061433" } ] } } ], "crossref": [ { "id": "E1BF30", "url": "https://alphafold.ebi.ac.uk/entry/E1BF30", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050394", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050394", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532238", "url": "https://www.ncbi.nlm.nih.gov/gene/532238", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532238", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532238", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HQEQEDF", "url": "https://omabrowser.org/oma/group/HQEQEDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF30", "url": "https://www.orthodb.org/?gene=E1BF30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF30-1", "url": "https://www.uniprot.org/uniprotkb/E1BF30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDENQSSVLDFFLLGVSSHQEQEDFFFVLFLFIYPITLIGNLLIILAIHSDIRLHNPMYFLLANLSFVDIFFSSVTIPKALANHLLGSKAISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAITRPLHYTIIMSPWTCVLLVIGSWVVGNGNALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFNVKMMYLGVGVFSMPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKDAVITVMYIAVTPVLNPFIYTLRNRVMKDALEKLFSKRTSSHPT", "length": 312, "header": "tr|E1BF30-1|E1BF30_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1D OS=Bos taurus OX=9913 GN=OR1A1D PE=3 SV=1 CANONICAL=E1BF30-1" }, "isoforms": [ { "isoform_ac": "E1BF30-1", "url": "https://www.uniprot.org/uniprotkb/E1BF30/entry#E1BF30-1", "sequence": { "sequence": "MRDENQSSVLDFFLLGVSSHQEQEDFFFVLFLFIYPITLIGNLLIILAIHSDIRLHNPMYFLLANLSFVDIFFSSVTIPKALANHLLGSKAISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAITRPLHYTIIMSPWTCVLLVIGSWVVGNGNALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFNVKMMYLGVGVFSMPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKDAVITVMYIAVTPVLNPFIYTLRNRVMKDALEKLFSKRTSSHPT", "length": 312, "header": "tr|E1BF30-1|E1BF30_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1D OS=Bos taurus OX=9913 GN=OR1A1D PE=3 SV=1 CANONICAL=E1BF30-1" }, "locus": { "chromosome": "19", "start_pos": 23936738, "end_pos": 23935803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055781.2", "url": "https://www.ensembl.org/id/ENSBTAT00000055781.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000047878.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 280, "start_aa": "Thr", "end_pos": 280, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532238", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532238", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZFE0-1", "protein_name": "Olfactory receptor family 1 subfamily A member 1B", "gene_name": "Or1a1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MREENESSTTEFTLLGVTRQREQEYFFFILFLFIYPITVFGNTLIILAIHSDIRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCMAQMFFMIGLANTDSYILAAMAYDRAVAISRPLHYATIMSPQLCILLVAGSWVIGNGNSLPHTILTARLSFCGNRDVANFYCDITPLLQLSCSDIRFNVKMMYFGVGVFSVPLLFIIISYVRVFSTVLRVPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLASYSLKHALITVMYTTVTPMLNPFIYSLRNRDMKAALKKLFHCPSSSSSSST", "length": 314 }, "evidence": [ { "id": "E1BF30", "url": "https://omabrowser.org/oma/group/E1BF30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TRX1-1", "protein_name": "Olfactory receptor family 1 subfamily A member 1B", "gene_name": "Or1a1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MREENESSTTDFTLLGVTRQREQEYFFFILFLFIYPITVFGNMLIILAIHSDTRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCMAQMYFMIGLANTDSYILAAMAYDRAVAISRPLHYATIMSPQLCVLLVAGSWVIANANALPHTLLTARLSFCGNKDVANFYCDITPLLQLSCSDIRFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRVPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKHALITVMYTAVTPMLNPFIYSLRNRDMKAALKKLFHCPSSSSSLM", "length": 313 }, "evidence": [ { "id": "E1BF30", "url": "https://omabrowser.org/oma/group/E1BF30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BF30", "url": "https://www.uniprot.org/uniprotkb/E1BF30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF30-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF30-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF30" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF30" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 280 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF33-1", "uniprot_ac": "E1BF33", "uniprot_id": "E1BF33_BOVIN", "mass": { "chemical_mass": 14446.0, "monoisotopic_mass": 14446.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Small ribosomal subunit protein uS17m", "type": "recommended", "evidence": [ { "id": "E1BF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF33/entry#names_and_taxonomy" } ] }, { "name": "28S ribosomal protein S17, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF33/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BF33", "locus": {} } ], "crossref": [ { "id": "E1BF33", "url": "https://alphafold.ebi.ac.uk/entry/E1BF33", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023186", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023186", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KHFREND", "url": "https://omabrowser.org/oma/group/KHFREND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24088", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24088", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24088:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24088:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF33-1", "url": "https://www.uniprot.org/uniprotkb/E1BF33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVVRSSVHAKWIVGKVIGTAMQKTAKVRVTRLVLDPYLLKYFNKQKTYFAHDALQQCTVGDIVLLKALPVPRTKHVKHELAEIVFKVGQVVDPVTGKRCAGTTYLESPVDLETTPLAKNLEELSLSTTQ", "length": 130, "header": "tr|E1BF33-1|E1BF33_BOVIN Isoform 1 of Small ribosomal subunit protein uS17m OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BF33-1" }, "isoforms": [ { "isoform_ac": "E1BF33-1", "url": "https://www.uniprot.org/uniprotkb/E1BF33/entry#E1BF33-1", "sequence": { "sequence": "MSVVRSSVHAKWIVGKVIGTAMQKTAKVRVTRLVLDPYLLKYFNKQKTYFAHDALQQCTVGDIVLLKALPVPRTKHVKHELAEIVFKVGQVVDPVTGKRCAGTTYLESPVDLETTPLAKNLEELSLSTTQ", "length": 130, "header": "tr|E1BF33-1|E1BF33_BOVIN Isoform 1 of Small ribosomal subunit protein uS17m OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BF33-1" }, "locus": { "chromosome": "10", "start_pos": 3638660, "end_pos": 3638271, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001335.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001335.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047871.1", "url": "https://www.ensembl.org/id/ENSBTAP00000047871.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1UDM1-1", "protein_name": "Small ribosomal subunit protein uS17m", "gene_name": "MRPS17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSIARSSVHAKWVVGKVIGTAMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLKALPVPRTKHVKHELAEIIFKVGQVIDPVTGKPCAGTTYLESPISPESTRLTKNLEALQLSSTQ", "length": 130 }, "evidence": [ { "id": "E1BF33", "url": "https://omabrowser.org/oma/group/E1BF33/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial small ribosomal subunit", "id": "GO:0005763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005763", "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "E1BF33", "url": "https://www.uniprot.org/uniprotkb/E1BF33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF33-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 130, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF33-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF33" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF46-1", "uniprot_ac": "E1BF46", "uniprot_id": "E1BF46_BOVIN", "mass": { "chemical_mass": 239815.0, "monoisotopic_mass": 239815.0 }, "refseq": { "ac": "XP_005224004", "name": "zinc finger protein 407", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224004" }, "gene_names": [ { "name": "ZNF407", "type": "recommended", "evidence": [ { "id": "E1BF46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ] }, { "name": "ZNF407", "type": "synonym", "evidence": [ { "id": "XP_005224004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224004" } ] } ], "protein_names": [ { "name": "Zinc finger protein 407", "type": "synonym", "evidence": [ { "id": "E1BF46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF46/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 407", "type": "synonym", "evidence": [ { "id": "XP_005224004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224004" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF407", "url": "https://www.uniprot.org/uniprotkb/E1BF46", "locus": { "chromosome": "24", "start_pos": 3571189, "end_pos": 3936109, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022887", "url": "https://www.ensembl.org/id/ENSBTAG00000022887" } ] } } ], "crossref": [ { "id": "ENSBTAG00000022887", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022887", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530360", "url": "https://www.ncbi.nlm.nih.gov/gene/530360", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050688", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050688", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530360", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530360", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224004", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224004", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF46-1", "url": "https://www.uniprot.org/uniprotkb/E1BF46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDPGKKLGSDEGDHVNEEAEHPSHSASHGVDRGPVSDETADSAENSTNKRGFAESSDLDHIVEEDNGNKRASKRMKLAEAEPLGPGEPRTHGSGSPEGTGSGEGVALPGSEVEPLSSGRDGSPGLPGHPSPGEMAAEKEPAQETTAFLDLGGEPPSPPKEMRGSGALGGPCACSPVSCPHVEKHAVRPSPRPEDQACGPAADGGLAFPGHTGQARGPPRAFSCELCGFQCAEENLLNAHCLGKTHLRRQNLAARGGFVQILTKQPLPKKPSPVGAKAGRTKPRASRPVARNGDSKALRSVGAGTFRDFRGSFSKQSGHGSELRVEMRPSRNTSPEKMEVVEENVTSHDAAGNPENQSRKLGMAVTSERLLDRLESSRNTAQAAPGLSTASRPRAERGFLVLGSGFRRRAGAFALKGQVKKRCGLLGVSKRGANEVQRLYSKHLRAPIKMSDAESAPLHGDPRLIPPETQAPKQDRTNAHLPGSSDSLARRPAPDHQVACTCSACGHTATSRAELEIHVTRCHVGELRFHCQTCGFSSTSRRDVEEHAHSHQHQQTASGLRCQCCLFTSPNEVDLRDHMKEKHSMGFLCPPCHLFFSSEKDMEEHRATEKHIHLLGQTKSSQSFNGDSALQTFPLSTLESENAKVSVSEAGKSAQEEPAKSRVSHGNEARHSSKPQFQCKKCFYKTRSSTVLTRHIKLRHGQDYHFLCKACNLYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCIGANDKKEELTVPGNGRTEGHGEGVQIQEQSCLDQSILPPQELSLSGVITKEGELAPPPTPKRGRPKGNISRTCSHCGLLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCATKKHKGRVEIEASGKQSSDIVVGPEGGNLDASRKNTSVADEPANPPVEADTSVSEQPPLEQGSPVEVEVENVFHPEDRETGSHLIEKKEQTSVDPEDLQGDTCPQKDDASTDENRCTHCEFKAHSSTSLELHVKRKHTREFAFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNSTNVQASSSEVSKTIIIPQGQQQQNSEEFQIISDQPSETLKSRNAADCSILDENTSLDMSKVFCASDSVETETEEDSNLSEDHSFCETFQQPLAKDKVIKPEEMVPLSISSNCGSPSKFQNENSGSSALNHETAKKRHSMLNDISSPNTHGESDGGNAEDKADKVLGKRGCLRAVDGEHPAKSAMLTAPRDLLNLGSSDQDRAGSMQSSGDLKDVPGDPVLESKEILMNSRHETKVILEEDGPASDSTIDNNDVYETIISIDDKGQAVYSFGRFDSSIIRIKNPEDGELFDQSQEGLVAAGVRMSELPLKDCAQGVKKKKADSSSFVESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNIPVEFRNHLKEQHPDIENPDLAYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEESPVKDRPLRSSRRPAAPPEPVQQVIIIQGYEGEFALDASVEETAAATLQTLALAGQVARVVHITEDGQVIAAGQSGAQGGSGAPSPGLPEPLADGATQVVVVGGSMEGHGMDEPLSPSGAVIQQVTKQEILGLAEAGVPPPDAASALDALLCAVTELGGAEGPAAAEEKGRAGPRDVLVQLPGQEAATPAAPEIHVFHDGPDGAAATEPVEVLTQLVRPAAVIASQERAQVAFKKVVQGMLQFAVCDSAAAGQLMKDGVTQVIVNEEGTVHMLAREGSQIIMQEAEARGPHVDLAEADGEISQIIVTEELVQAMVQESGGGFPEGATHYIVTELPPGVQDEPAVYSHTVIEAAGSQELLQAGAVVPSGAEQLTSMVIYTQEGSPAAAVIQSQRDSSEVHEA", "length": 2209, "header": "tr|E1BF46-1|E1BF46_BOVIN Isoform 1 of Zinc finger protein 407 OS=Bos taurus OX=9913 GN=ZNF407 PE=4 SV=4 CANONICAL=E1BF46-1" }, "isoforms": [ { "isoform_ac": "E1BF46-1", "url": "https://www.uniprot.org/uniprotkb/E1BF46/entry#E1BF46-1", "sequence": { "sequence": "MMDPGKKLGSDEGDHVNEEAEHPSHSASHGVDRGPVSDETADSAENSTNKRGFAESSDLDHIVEEDNGNKRASKRMKLAEAEPLGPGEPRTHGSGSPEGTGSGEGVALPGSEVEPLSSGRDGSPGLPGHPSPGEMAAEKEPAQETTAFLDLGGEPPSPPKEMRGSGALGGPCACSPVSCPHVEKHAVRPSPRPEDQACGPAADGGLAFPGHTGQARGPPRAFSCELCGFQCAEENLLNAHCLGKTHLRRQNLAARGGFVQILTKQPLPKKPSPVGAKAGRTKPRASRPVARNGDSKALRSVGAGTFRDFRGSFSKQSGHGSELRVEMRPSRNTSPEKMEVVEENVTSHDAAGNPENQSRKLGMAVTSERLLDRLESSRNTAQAAPGLSTASRPRAERGFLVLGSGFRRRAGAFALKGQVKKRCGLLGVSKRGANEVQRLYSKHLRAPIKMSDAESAPLHGDPRLIPPETQAPKQDRTNAHLPGSSDSLARRPAPDHQVACTCSACGHTATSRAELEIHVTRCHVGELRFHCQTCGFSSTSRRDVEEHAHSHQHQQTASGLRCQCCLFTSPNEVDLRDHMKEKHSMGFLCPPCHLFFSSEKDMEEHRATEKHIHLLGQTKSSQSFNGDSALQTFPLSTLESENAKVSVSEAGKSAQEEPAKSRVSHGNEARHSSKPQFQCKKCFYKTRSSTVLTRHIKLRHGQDYHFLCKACNLYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCIGANDKKEELTVPGNGRTEGHGEGVQIQEQSCLDQSILPPQELSLSGVITKEGELAPPPTPKRGRPKGNISRTCSHCGLLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCATKKHKGRVEIEASGKQSSDIVVGPEGGNLDASRKNTSVADEPANPPVEADTSVSEQPPLEQGSPVEVEVENVFHPEDRETGSHLIEKKEQTSVDPEDLQGDTCPQKDDASTDENRCTHCEFKAHSSTSLELHVKRKHTREFAFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNSTNVQASSSEVSKTIIIPQGQQQQNSEEFQIISDQPSETLKSRNAADCSILDENTSLDMSKVFCASDSVETETEEDSNLSEDHSFCETFQQPLAKDKVIKPEEMVPLSISSNCGSPSKFQNENSGSSALNHETAKKRHSMLNDISSPNTHGESDGGNAEDKADKVLGKRGCLRAVDGEHPAKSAMLTAPRDLLNLGSSDQDRAGSMQSSGDLKDVPGDPVLESKEILMNSRHETKVILEEDGPASDSTIDNNDVYETIISIDDKGQAVYSFGRFDSSIIRIKNPEDGELFDQSQEGLVAAGVRMSELPLKDCAQGVKKKKADSSSFVESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNIPVEFRNHLKEQHPDIENPDLAYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEESPVKDRPLRSSRRPAAPPEPVQQVIIIQGYEGEFALDASVEETAAATLQTLALAGQVARVVHITEDGQVIAAGQSGAQGGSGAPSPGLPEPLADGATQVVVVGGSMEGHGMDEPLSPSGAVIQQVTKQEILGLAEAGVPPPDAASALDALLCAVTELGGAEGPAAAEEKGRAGPRDVLVQLPGQEAATPAAPEIHVFHDGPDGAAATEPVEVLTQLVRPAAVIASQERAQVAFKKVVQGMLQFAVCDSAAAGQLMKDGVTQVIVNEEGTVHMLAREGSQIIMQEAEARGPHVDLAEADGEISQIIVTEELVQAMVQESGGGFPEGATHYIVTELPPGVQDEPAVYSHTVIEAAGSQELLQAGAVVPSGAEQLTSMVIYTQEGSPAAAVIQSQRDSSEVHEA", "length": 2209, "header": "tr|E1BF46-1|E1BF46_BOVIN Isoform 1 of Zinc finger protein 407 OS=Bos taurus OX=9913 GN=ZNF407 PE=4 SV=4 CANONICAL=E1BF46-1" }, "locus": { "chromosome": "24", "start_pos": 3931437, "end_pos": 3572193, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031106.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031106.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031069.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031069.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1026, "start_aa": "Thr", "end_pos": 1026, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1026", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 811, "start_aa": "Thr", "end_pos": 811, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr811", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:530360", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530360", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BF46", "url": "https://www.uniprot.org/uniprotkb/E1BF46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1048, "end_pos": 1050, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1102, "end_pos": 1104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1126, "end_pos": 1128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" }, { "start_pos": 837, "end_pos": 839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 907, "end_pos": 909, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF46" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 529, "end_pos": 556, "start_aa": "Phe", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 811, 1026 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1048, "end_pos": 1050 }, { "start_pos": 1102, "end_pos": 1104 }, { "start_pos": 1126, "end_pos": 1128 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 820, "end_pos": 822 }, { "start_pos": 837, "end_pos": 839 }, { "start_pos": 907, "end_pos": 909 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF57-1", "uniprot_ac": "E1BF57", "uniprot_id": "E1BF57_BOVIN", "mass": { "chemical_mass": 100356.0, "monoisotopic_mass": 100356.0 }, "refseq": { "ac": "XP_024855814", "name": "integrator complex subunit 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855814" }, "gene_names": [ { "name": "INTS6", "type": "recommended", "evidence": [ { "id": "E1BF57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ] }, { "name": "INTS6", "type": "synonym", "evidence": [ { "id": "XP_024855814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855814" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 6", "type": "synonym", "evidence": [ { "id": "E1BF57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF57/entry#names_and_taxonomy" } ] }, { "name": "integrator complex subunit 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855814" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS6", "url": "https://www.uniprot.org/uniprotkb/E1BF57", "locus": { "chromosome": "12", "start_pos": 20816690, "end_pos": 20903201, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002970", "url": "https://www.ensembl.org/id/ENSBTAG00000002970" } ] } } ], "crossref": [ { "id": "E1BF57", "url": "https://alphafold.ebi.ac.uk/entry/E1BF57", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002970", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002970", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00198", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00198", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509695", "url": "https://www.ncbi.nlm.nih.gov/gene/509695", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509695", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509695", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LNQNHYG", "url": "https://omabrowser.org/oma/group/LNQNHYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF57", "url": "https://www.orthodb.org/?gene=E1BF57", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12957:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12957:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855814", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW42", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW42-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF57-1", "url": "https://www.uniprot.org/uniprotkb/E1BF57-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPIVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGVPKRRRCMSPLLRGRQQSPVVNNHIGGKGPPAPMTQAQPDLIKPLPLHKISEATNDSTMDDVVENHVADQLSSDTTPNAMEAEFSGSSPANLLERPTNHTEALGHDHLGTNDLTVGGFLENHEEPRDKEQCPEENIPASSLNRGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 887, "header": "tr|E1BF57-1|E1BF57_BOVIN Isoform 1 of Integrator complex subunit 6 OS=Bos taurus OX=9913 GN=INTS6 PE=4 SV=3 CANONICAL=E1BF57-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW42-1", "url": "https://www.uniprot.org/uniprotkb/E1BF57/entry#A0A3Q1LW42-1", "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPIVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGVPKRRRCMSPLLRGRQQSPVVNNHIGGKGPPAPMTQAQPDLIKPLPLHKISEATNDSTMDDVVENHVADQLSSDTTPNAMEAEFSGSSPANLLERPTNHTEALGHDHLGTNDLTVGGFLENHEEPRDKEQCPEENIPASSLNRGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 837, "header": "tr|A0A3Q1LW42-1|A0A3Q1LW42_BOVIN Computationally mapped isoform of Integrator complex subunit 6 OS=Bos taurus OX=9913 GN=INTS6 PE=4 SV=2 CANONICAL=E1BF57-1" }, "locus": { "chromosome": "12", "start_pos": 20903002, "end_pos": 20817694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066949.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066949.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064908.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064908.2" } ] } }, { "isoform_ac": "E1BF57-1", "url": "https://www.uniprot.org/uniprotkb/E1BF57/entry#E1BF57-1", "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPIVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGVPKRRRCMSPLLRGRQQSPVVNNHIGGKGPPAPMTQAQPDLIKPLPLHKISEATNDSTMDDVVENHVADQLSSDTTPNAMEAEFSGSSPANLLERPTNHTEALGHDHLGTNDLTVGGFLENHEEPRDKEQCPEENIPASSLNRGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 887, "header": "tr|E1BF57-1|E1BF57_BOVIN Isoform 1 of Integrator complex subunit 6 OS=Bos taurus OX=9913 GN=INTS6 PE=4 SV=3 CANONICAL=E1BF57-1" }, "locus": { "chromosome": "12", "start_pos": 20903002, "end_pos": 20817694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003868.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003868.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003868.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003868.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509695", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509695", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZU0-1", "protein_name": "Integrator complex subunit 6", "gene_name": "INTS6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPILLFLIDTSASMNQRTHLGTTYLDIAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITVTDGSKLTTTSGIQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGVSSPESEQMTGVPVDDSAITPMCEVTGGRSYCVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPIDDGQVDITRPFGPQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWLQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADNVEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVAQETGIKVRSRSHNLSMAHRNDFQHLLQGITGEIPHRPLDFNMKEYAGFQIALLNKDLKPQTFRNAYDIPRRNLLDQLTRMRSNLLKSTRKLLKGQDEDQVHSVPIAQMGNYQEYLKQIPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVSGPQNKHKRPGEPSMQGIPKRRRCMSPLLRGRPQTPPVVNNHIGGKGPPSPITQAQLDLVKPIPIHKTSEANNEIAMDDVVENHVIDPLSSDDFPDAVDSEFSMSSSPFNSLDRSATHIEGAGHEHLGNNLNVDGFLENHDESSSKEQNTEDSLPISSTSKGKKTVPCRSSREINIELRAKIMKEIRKPGRKYERIFSLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLESFLEEIHRRSNQVNHINSS", "length": 888 }, "evidence": [ { "id": "E1BF57", "url": "https://omabrowser.org/oma/group/E1BF57/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6AP01-1", "protein_name": "Integrator complex subunit 6", "gene_name": "Ints6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTVSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPAEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSVVDDVVENHVADQLSSDMTTNAMDTEFLTSPANLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEESRSKEQSAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 883 }, "evidence": [ { "id": "E1BF57", "url": "https://omabrowser.org/oma/group/E1BF57/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PCM2-1", "protein_name": "Integrator complex subunit 6", "gene_name": "Ints6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPPPAEEGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSIVDDVVENHVADQLSSDMTPNAMDTEFLTSPPNLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKEQSAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 883 }, "evidence": [ { "id": "E1BF57", "url": "https://omabrowser.org/oma/group/E1BF57/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UL03-1", "protein_name": "Integrator complex subunit 6", "gene_name": "INTS6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN", "length": 887 }, "evidence": [ { "id": "E1BF57", "url": "https://omabrowser.org/oma/group/E1BF57/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of transcription elongation by RNA polymerase II", "id": "GO:0034243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034243", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "RNA polymerase II transcription initiation surveillance", "id": "GO:0160240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160240", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" }, { "name": "INTAC complex", "id": "GO:0160232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160232", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "E1BF57", "url": "https://www.uniprot.org/uniprotkb/E1BF57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 750, "end_pos": 752, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF57-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 887, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF57-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF57" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF57" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 227, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 707, "end_pos": 709 }, { "start_pos": 750, "end_pos": 752 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF69-1", "uniprot_ac": "E1BF69", "uniprot_id": "E1BF69_BOVIN", "mass": { "chemical_mass": 49954.0, "monoisotopic_mass": 49954.0 }, "refseq": { "ac": "XP_003585939", "name": "interferon-induced protein 44-like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585939" }, "gene_names": [ { "name": "IFI44L", "type": "recommended", "evidence": [ { "id": "E1BF69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF69" } ] }, { "name": "IFI44L", "type": "synonym", "evidence": [ { "id": "XP_003585939", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585939" } ] } ], "protein_names": [ { "name": "Interferon-induced protein 44-like", "type": "recommended", "evidence": [ { "id": "E1BF69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF69/entry#names_and_taxonomy" } ] }, { "name": "interferon-induced protein 44-like isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003585939", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585939" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF69", "url": "https://www.uniprot.org/uniprotkb/E1BF69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFI44L", "url": "https://www.uniprot.org/uniprotkb/E1BF69", "locus": { "chromosome": "3", "start_pos": 66053592, "end_pos": 66071430, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030932", "url": "https://www.ensembl.org/id/ENSBTAG00000030932" } ] } } ], "crossref": [ { "id": "E1BF69", "url": "https://alphafold.ebi.ac.uk/entry/E1BF69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030932", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030932", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508347", "url": "https://www.ncbi.nlm.nih.gov/gene/508347", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508347", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508347", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRLTWNE", "url": "https://omabrowser.org/oma/group/TRLTWNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF69", "url": "https://www.orthodb.org/?gene=E1BF69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14241:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14241:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9909505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003585939", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585939", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF69", "url": "https://www.uniprot.org/uniprotkb/E1BF69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF69-1", "url": "https://www.uniprot.org/uniprotkb/E1BF69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVTTTLTWNEERSFQKLLGNVSLRLLYKSSVHGRSTVEMQNRCRCQGPIVTVIYHSNSIFGVFTLGHSSDMSESFTEPNASFFFSLQKNETMEMKTVVLNSTVTFYRNNLTFCFSSYYNQKLSLNFEESRIYIPRIFEEELIVKSHAKSTFLECEVFRVEGIKDEAGYINRITRAIQHRNSLLADVRAYSPYADLVSEIRILLLGPVGSGKSSFFNSVKSIFQGHLTRQAIVGSDVTSITEQYRIYSIKDGKNGQSLPFMLCDSMGLDEKEGVGLCVDDIPHILKGCVPDRYEFSPQKPITPKHPTFITSPSLKDRIHCVAYVFDINSMDNLSSKMVAKLKQIQKEVINCGVAQVALLTKVNNCNEVLQDNFLKMNKAMISQSQIQNVNKILGIPLSRILVVDNYASEREMDPVKDILILSALKQMFRATDDFLEDLPLE", "length": 441, "header": "tr|E1BF69-1|E1BF69_BOVIN Isoform 1 of Interferon-induced protein 44-like OS=Bos taurus OX=9913 GN=IFI44L PE=3 SV=2 CANONICAL=E1BF69-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5C3-1", "url": "https://www.uniprot.org/uniprotkb/E1BF69/entry#A0AAA9T5C3-1", "sequence": { "sequence": "MLCDSMGLDEKEGVGLCVDDIPHILKGCVPDRYEFSPQKPITPKHPTFITSPSLKDRIHCVAYVFDINSMDNLSSKMVAKLKQIQKEVINCGVAQVALLTKVNNCNEVLQDNFLKMNKAMISQSQIQNVNKILGIPLSRILVVDNYASEREMDPVKDILILSALKQMFRATDDFLEDLPLETDTTAGMFQLCIS", "length": 194, "header": "tr|A0AAA9T5C3-1|A0AAA9T5C3_BOVIN Computationally mapped isoform of Interferon induced protein 44 like OS=Bos taurus OX=9913 GN=IFI44L PE=4 SV=1 CANONICAL=E1BF69-1" }, "locus": { "chromosome": "3", "start_pos": 66060079, "end_pos": 66054230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118590.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118590.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091927.1" } ] } }, { "isoform_ac": "E1BF69-1", "url": "https://www.uniprot.org/uniprotkb/E1BF69/entry#E1BF69-1", "sequence": { "sequence": "MAVTTTLTWNEERSFQKLLGNVSLRLLYKSSVHGRSTVEMQNRCRCQGPIVTVIYHSNSIFGVFTLGHSSDMSESFTEPNASFFFSLQKNETMEMKTVVLNSTVTFYRNNLTFCFSSYYNQKLSLNFEESRIYIPRIFEEELIVKSHAKSTFLECEVFRVEGIKDEAGYINRITRAIQHRNSLLADVRAYSPYADLVSEIRILLLGPVGSGKSSFFNSVKSIFQGHLTRQAIVGSDVTSITEQYRIYSIKDGKNGQSLPFMLCDSMGLDEKEGVGLCVDDIPHILKGCVPDRYEFSPQKPITPKHPTFITSPSLKDRIHCVAYVFDINSMDNLSSKMVAKLKQIQKEVINCGVAQVALLTKVNNCNEVLQDNFLKMNKAMISQSQIQNVNKILGIPLSRILVVDNYASEREMDPVKDILILSALKQMFRATDDFLEDLPLE", "length": 441, "header": "tr|E1BF69-1|E1BF69_BOVIN Isoform 1 of Interferon-induced protein 44-like OS=Bos taurus OX=9913 GN=IFI44L PE=3 SV=2 CANONICAL=E1BF69-1" }, "locus": { "chromosome": "3", "start_pos": 66064396, "end_pos": 66054425, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031066.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031066.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031029.4", "url": "https://www.ensembl.org/id/ENSBTAP00000031029.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508347", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508347", "resource": "KEGG Pathway" }, { "id": "R-BTA-9909505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909505", "resource": "Reactome", "description": "Modulation of host responses by IFN-stimulated genes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIB9-1", "protein_name": "Interferon-induced protein 44-like", "gene_name": "IFI44L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVTPRLTWNEEKSLQKLLGNVSLRLLYKSSVHGNSFGTMLNKCSCQGSTILMVYLPNNVFGIFVLESYPEMSEHLKKPTTSFLLSFQKNKIMEMTAAFFNSTVDLIDNKLRFNFSQVQYVLLRSNTQNIFIPRLLGEKLGLTYDFKSQYTEYEVFRVEGMKDEPGYINRIAGATPHRDSLLAELRAYRPYADLVSEIRILLLGPVGSGKSSFFNSVKSIFRGHLTRQAIVGSDISTITEKYRIYSIKDEKDGKSLPFMLCDSMGLNEKDGVGLCVDDIPHILKGCMPDRYQFNQKPITPKHPTFITSPSLNHRIHCVAYVFDINSIDNLSFQMLAKVKQVQKEVLKCGVSQVALLTKVNNCNGVLQDNFLQMSESMIYKSQVRDVNMMLGIPKSNILVVENYASEREMDPLQDILILSALKQMTRAADDFLEDLPLETDAIAGMFQLCMRCQLPGSRHLAQTGIADSLFETLLPFMFCLLSLRASN", "length": 487 }, "evidence": [ { "id": "E1BF69", "url": "https://omabrowser.org/oma/group/E1BF69/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R4J5-1", "protein_name": "Interferon-induced protein 44-like", "gene_name": "Ifi44l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNMLGLRGSYRNTKVTTRLTWIEEKILEKLLGNASLTLLYQSNVHKRCTLEMTKKCSLQGSTMTIVYLEQEVVGVFMLEDFPDKDSKKTSTCAWFSFERNKISSGISALVLNTLVKVNSTSLQMSSISGLTLIVYPSKEGLYLNEAVIKNLELNVKQSQYLECEIFRVDGIKNNPGFIKKMVTARQHRGKFLSTLRAYRPYADLVSEVRILLVGPVGSGKSSFVNSVKSSFQGRLTRQAIVGSDKSSITTQYKVYSIKDEKNKETLPFMLCDSMGLEDEKEAGLCTDDIPHILKGCVPDRYQFNPREPIKLKHFTYAASPPLKDRIHCVAFVLDINSVDTLSDKMVAKLKKIRKDVVDCGVGCVALLTNVSDYDEVLDNNLVNMTENMTSLNQVQNVRNMLNIPVANILMVSNYASERMLEPLKDVLIFAALQQMLRAADDALEDLPLEDTASDDGSFNNSSHIKNEGKLGEVKRREMS", "length": 479 }, "evidence": [ { "id": "E1BF69", "url": "https://omabrowser.org/oma/group/E1BF69/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q53G44-1", "protein_name": "Interferon-induced protein 44-like", "gene_name": "IFI44L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERCSRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQPCI", "length": 452 }, "evidence": [ { "id": "E1BF69", "url": "https://omabrowser.org/oma/group/E1BF69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BF69", "url": "https://www.uniprot.org/uniprotkb/E1BF69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BF69", "url": "https://www.uniprot.org/uniprotkb/E1BF69" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "E1BF69", "url": "https://www.uniprot.org/uniprotkb/E1BF69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF69-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF69-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF69" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF69" }, { "id": "PS51886", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TLDc", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 161, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 110, "end_pos": 112 }, { "start_pos": 21, "end_pos": 23 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF74-1", "uniprot_ac": "E1BF74", "uniprot_id": "E1BF74_BOVIN", "mass": { "chemical_mass": 57332.0, "monoisotopic_mass": 57332.0 }, "refseq": { "ac": "XP_003586998", "name": "ras association domain-containing protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586998" }, "gene_names": [ { "name": "RASSF10", "type": "recommended", "evidence": [ { "id": "E1BF74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ] }, { "name": "RASSF10", "type": "synonym", "evidence": [ { "id": "XP_003586998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586998" } ] } ], "protein_names": [ { "name": "Ras association domain family member 10", "type": "synonym", "evidence": [ { "id": "E1BF74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF74/entry#names_and_taxonomy" } ] }, { "name": "ras association domain-containing protein 10", "type": "synonym", "evidence": [ { "id": "XP_003586998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586998" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASSF10", "url": "https://www.uniprot.org/uniprotkb/E1BF74", "locus": { "chromosome": "15", "start_pos": 39679283, "end_pos": 39682197, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011914", "url": "https://www.ensembl.org/id/ENSBTAG00000011914" } ] } } ], "crossref": [ { "id": "E1BF74", "url": "https://alphafold.ebi.ac.uk/entry/E1BF74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011914", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011914", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16132", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16132", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514824", "url": "https://www.ncbi.nlm.nih.gov/gene/514824", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514824", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514824", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KADLDYS", "url": "https://omabrowser.org/oma/group/KADLDYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF74", "url": "https://www.orthodb.org/?gene=E1BF74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15286", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15286", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15286:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15286:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21712", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27976", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27976", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003586998", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF74-1", "url": "https://www.uniprot.org/uniprotkb/E1BF74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRRGAAGDPPGPGELPEPLDEDDEDDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCSARGVPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQPSSPCSSTSSSAASSCSSSSPRATESASVERMETLVHLVLSQDHTIRQQVQRLRELDREIDRYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGTGPGEEPEPEPDPEPAAATTTTPPLDGEAKAVALEELARRCDDLLQLQEQRAQQEELLERLSAEIQEELNQRWMRRRQEELATREEPPDAEGGLDGELLLERERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKERELQGLLQTLHTLELTVAPDGTPVSSGPSRDPGPQACAEVWVDQARGLAKSCPGNDEDSDTGLSSMHSQDSDSVPVCESLV", "length": 511, "header": "tr|E1BF74-1|E1BF74_BOVIN Isoform 1 of Ras association domain family member 10 OS=Bos taurus OX=9913 GN=RASSF10 PE=4 SV=3 CANONICAL=E1BF74-1" }, "isoforms": [ { "isoform_ac": "E1BF74-1", "url": "https://www.uniprot.org/uniprotkb/E1BF74/entry#E1BF74-1", "sequence": { "sequence": "MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRRGAAGDPPGPGELPEPLDEDDEDDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCSARGVPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQPSSPCSSTSSSAASSCSSSSPRATESASVERMETLVHLVLSQDHTIRQQVQRLRELDREIDRYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGTGPGEEPEPEPDPEPAAATTTTPPLDGEAKAVALEELARRCDDLLQLQEQRAQQEELLERLSAEIQEELNQRWMRRRQEELATREEPPDAEGGLDGELLLERERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKERELQGLLQTLHTLELTVAPDGTPVSSGPSRDPGPQACAEVWVDQARGLAKSCPGNDEDSDTGLSSMHSQDSDSVPVCESLV", "length": 511, "header": "tr|E1BF74-1|E1BF74_BOVIN Isoform 1 of Ras association domain family member 10 OS=Bos taurus OX=9913 GN=RASSF10 PE=4 SV=3 CANONICAL=E1BF74-1" }, "locus": { "chromosome": "15", "start_pos": 39681702, "end_pos": 39680170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015807.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015807.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015807.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015807.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514824", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514824", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZSM2-1", "protein_name": "Ras association domain family member 10", "gene_name": "RASSF10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPEERKISVWICQEEKLISGLSRRTTCSDVVRVLLEDSHHRRQRPAPPEPGGGMLSGPPHSYCIVEKWRGFERILPNKTKILRLWVAWGDEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPGHGLGAARASLALTQERQRRVVRKAFRKLAKINKKRQQPLAREASSAERMETLVHLVLSQDHTIRQQIQRLRELDREIDRYEAKIHLDRMKRHGVNYVQDTYLVGAGGEEPGREAQPGAGRPEDDYARKCEEVLQLQEQRARQEELLEHLAAEIQEELNERWMKRRRDELELAAGPGLAEADCHTTELSGGGEGELQLEHERVKTQLSTSLYIGLKLSTDLEAVKSDLDCTQRAWEARERELQRLLETLGTLDVAEAAAEPRGAAGGGWPEPGLRKDRADNDEDSDTGLSSMHSQDSDSVPVCESLV", "length": 433 }, "evidence": [ { "id": "E1BF74", "url": "https://omabrowser.org/oma/group/E1BF74/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6NK89-1", "protein_name": "Ras association domain-containing protein 10", "gene_name": "RASSF10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV", "length": 507 }, "evidence": [ { "id": "E1BF74", "url": "https://omabrowser.org/oma/group/E1BF74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BL43-1", "protein_name": "Ras association domain-containing protein 10", "gene_name": "Rassf10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRCRQRRGQRRGLTEDPSGQLELPEPPDENDEDDDDAMPPGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWTAWGDEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCLARGAPARPSLALTQEKQRRVVRKAFRKLAKLNRRRQQQPSSPCSSTSSSTASSCSSSARTHESASVERMETLVHLVLSQDHTIRQQVQRLRELDREIDRYEAKVHLDRMRRHGVNYVQDTYLVGAGIDLDGQTPEGEPEDATLEEKGTEPAAPLDSEAQAAALEELARRCDDLVRLQEERAQQEELLERLSAEIQEELNQRWMQRRNEELAAREESLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLSTDLEAVKADLDYSQQQRDIKERELQGLLQSLHTFEQTVVHDGALGSSGPSREPQPQTCAEMWVDQARGLAKSCPGNDEDSDTGLSSMHSQDSDSVPPVCESLV", "length": 508 }, "evidence": [ { "id": "E1BF74", "url": "https://omabrowser.org/oma/group/E1BF74/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ], "pmid": "" }, { "name": "positive regulation of neural precursor cell proliferation", "id": "GO:2000179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000179", "evidence": [ { "database": "UniProtKB", "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ], "pmid": "" }, { "name": "positive regulation of neurogenesis", "id": "GO:0050769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050769", "evidence": [ { "database": "UniProtKB", "id": "E1BF74", "url": "https://www.uniprot.org/uniprotkb/E1BF74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF74-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 511, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF74-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF74" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF74" }, { "id": "PS50200", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000259", "start_pos": 83, "end_pos": 134, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BF97-1", "uniprot_ac": "E1BF97", "uniprot_id": "E1BF97_BOVIN", "mass": { "chemical_mass": 17092.0, "monoisotopic_mass": 17092.0 }, "refseq": {}, "gene_names": [ { "name": "LOC132343864", "type": "recommended", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97" } ] } ], "protein_names": [ { "name": "Elongin-B", "type": "recommended", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#names_and_taxonomy" } ] }, { "name": "Elongin 18 kDa subunit", "type": "synonym", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#names_and_taxonomy" } ] }, { "name": "RNA polymerase II transcription factor SIII subunit B", "type": "synonym", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#names_and_taxonomy" } ] }, { "name": "SIII p18", "type": "synonym", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#names_and_taxonomy" } ] }, { "name": "Transcription elongation factor B polypeptide 2", "type": "synonym", "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97#function" }, { "database": "UniProtKB", "id": "ARBA00054216", "url": "https://www.uniprot.org/uniprotkb/ARBA00054216#function" }, { "database": "UniProtKB", "id": "A0AAA9T8U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132343864", "url": "https://www.uniprot.org/uniprotkb/E1BF97", "locus": {} } ], "crossref": [ { "id": "E1BF97", "url": "https://alphafold.ebi.ac.uk/entry/E1BF97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031582", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031582", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "132343864", "url": "https://www.ncbi.nlm.nih.gov/gene/132343864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132343864", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132343864", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIEPFSN", "url": "https://omabrowser.org/oma/group/CIEPFSN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13248:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13248:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T8U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF97-1", "url": "https://www.uniprot.org/uniprotkb/E1BF97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVFLMIRRGKTTIFTEAKESSTVFELKRVIQGILKRPPDEQRLYKDNQLLDDSRTLGECGFTRQTALPQAPVTVGLAFREDEAFEDVCIEPFSSPPELPDVMKPRDSGSRANGQAVQIPIPEGPDISIFSDSSCNRGPKGNSPCWSAELYNIA", "length": 154, "header": "tr|E1BF97-1|E1BF97_BOVIN Isoform 1 of Elongin-B OS=Bos taurus OX=9913 GN=LOC132343864 PE=3 SV=4 CANONICAL=E1BF97-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8U4-1", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#A0AAA9T8U4-1", "sequence": { "sequence": "MDVFLMIRRGKTTIFTEAKESSTVFELKRVIQGILKRPPDEQRLYKDNQLLDDSRTLGECGFTRQTALPQAPVTVGLAFREDEAFEDVCIEPFSSPPELPDVMKPRDSGSRANGQAVQ", "length": 118, "header": "tr|A0AAA9T8U4-1|A0AAA9T8U4_BOVIN Computationally mapped isoform of Elongin-B OS=Bos taurus OX=9913 GN=LOC132343864 PE=3 SV=1 CANONICAL=E1BF97-1" }, "locus": { "chromosome": "25", "start_pos": 27775798, "end_pos": 27775445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134210.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134210.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093043.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093043.1" } ] } }, { "isoform_ac": "E1BF97-1", "url": "https://www.uniprot.org/uniprotkb/E1BF97/entry#E1BF97-1", "sequence": { "sequence": "MDVFLMIRRGKTTIFTEAKESSTVFELKRVIQGILKRPPDEQRLYKDNQLLDDSRTLGECGFTRQTALPQAPVTVGLAFREDEAFEDVCIEPFSSPPELPDVMKPRDSGSRANGQAVQIPIPEGPDISIFSDSSCNRGPKGNSPCWSAELYNIA", "length": 154, "header": "tr|E1BF97-1|E1BF97_BOVIN Isoform 1 of Elongin-B OS=Bos taurus OX=9913 GN=LOC132343864 PE=3 SV=4 CANONICAL=E1BF97-1" }, "locus": { "chromosome": "25", "start_pos": 27778361, "end_pos": 27771585, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044774.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044774.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050199.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050199.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 74, "start_aa": "Thr", "end_pos": 74, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr74", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:132343864", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132343864", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "VCB complex", "id": "GO:0030891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030891", "evidence": [ { "database": "UniProtKB", "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97" } ], "pmid": "" }, { "name": "elongin complex", "id": "GO:0070449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070449", "evidence": [ { "database": "UniProtKB", "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "E1BF97", "url": "https://www.uniprot.org/uniprotkb/E1BF97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BF97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BF97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BF97" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BF97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF97" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 68, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 74 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFC1-1", "uniprot_ac": "E1BFC1", "uniprot_id": "E1BFC1_BOVIN", "mass": { "chemical_mass": 133069.0, "monoisotopic_mass": 133069.0 }, "refseq": { "ac": "XP_010816554", "name": "transcriptional-regulating factor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816554" }, "gene_names": [ { "name": "TRERF1", "type": "recommended", "evidence": [ { "id": "E1BFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ] }, { "name": "TRERF1", "type": "synonym", "evidence": [ { "id": "XP_010816554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816554" } ] } ], "protein_names": [ { "name": "Transcriptional regulating factor 1", "type": "synonym", "evidence": [ { "id": "E1BFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC1/entry#names_and_taxonomy" } ] }, { "name": "transcriptional-regulating factor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010816554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816554" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRERF1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1", "locus": { "chromosome": "23", "start_pos": 15938894, "end_pos": 15979222, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015321", "url": "https://www.ensembl.org/id/ENSBTAG00000015321" } ] } } ], "crossref": [ { "id": "E1BFC1", "url": "https://alphafold.ebi.ac.uk/entry/E1BFC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504797", "url": "https://www.ncbi.nlm.nih.gov/gene/504797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZA6", "url": "https://www.orthodb.org/?gene=A0A3Q1LZA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BFC1", "url": "https://www.orthodb.org/?gene=E1BFC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010816554", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816554", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDQQLYKTNHVAHGGENLFYQQPPLGVHGGLNHSYGNTVPGAGMDAPQASPISPHFPQDTRDGLGLAVGSKNLGQVDTSRQGGWGGHAGPGNHVQLRGNLTNSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEAPAAALPSRYQQASQQPHPGFTGGLSKPALQVGQHPSQGHLYYDYQQPLAQMPVQGGQSLQAPQMLSQHMQQLQPHQYYPPQQQTHAGQQRVSMQEMQPPPQQQIRPPQPQPQPQPRQGSMQIPQYYQSPPMIQPLPEPQQPQMHLQPSSYHRDPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQPYGHPVYQQSHLPQHQQPEDGQPKTYPGDRQAQAMLSSHGDLGPPDTGMGDAASSDLNRASSALPHRPLLSPGSIHLNNMGSQHQQLSPSAVWPQMHLPDGRAQPGSPESSGQPKGVFGEQFDAKNKLTCSICLKEFKSLPALNGHMRSHGGMRASPSLKQEEGEKAPAPPPQPQPPLPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFANSVAAAPSARDKPASSMSDDEMPVLVRMTLSPPHSPQGAAPNPPAEIPKKHQPGAAKAEEALRSAPAEKKKFRHRPEPLFIPPPPSYTPNLAASHSGATLYQSQLRSPRVLGDHLLLDPAHELPPYTPPPMLSPVRQGSGLFSNVLIAGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNLTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDVSALAQDTHRATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMAALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLSEIIDDCVTSEEDEEVEEEEDPEEDRKSTREEESELPKSPEPPQGPVLAPAEGPPLQALGQPSGSFICEMPNCGADCRCHVTPFLPQVFSSRQALNGHARIHGGTNQVTKARGTVPSGKQKPGSAQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGPQGLLPLDQLSLIKPIKDVDLLDDDVVQQLGGVMAEAEVVDTGLLLDDQASVLLQGDTEL", "length": 1221, "header": "tr|E1BFC1-1|E1BFC1_BOVIN Isoform 1 of Transcriptional regulating factor 1 OS=Bos taurus OX=9913 GN=TRERF1 PE=4 SV=4 CANONICAL=E1BFC1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1/entry#A0A3Q1LZA6-1", "sequence": { "sequence": "MGDQQLYKTNHVAHGGENLFYQQPPLGVHGGLNHSYGNTVPGAGMDAPQASPISPHFPQDTRDGLGLAVGSKNLGQVDTSRQGGWGGHAGPGNHVQLRGNLTNSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEAPAAALPSRYQQASQQPHPGFTGGLSKPALQVGQHPSQGHLYYDYQQPLAQMPVQGGQSLQAPQMLSQHMQQLQPHQYYPPQQQTHAGQQRVSMQEMQPPPQQQIRPPQPQPQPQPRQGSMQIPQYYQSPPMIQPLPEPQQPQMHLQPSSYHRDPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQPYGHPVYQQSHLPQHQQPEDGQPKTYPGDRQAQAMLSSHGDLGPPDTGMGDAASSDLNRASSALPHRPLLSPGSIHLNNMGSQHQQLSPSAVWPQMHLPDGRAQPGSPESSGQPKGVFGEQFDAKNKLTCSICLKEFKSLPALNGHMRSHGGMRASPSLKQEIPKKHQPGAAKAEEALRSAPAEKKKFRHRPEPLFIPPPPSYTPNLAASHSGATLYQSQLRSPRVLGDHLLLDPAHELPPYTPPPMLSPVRQGSGLFSNVLIAGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNLTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDVSALAQDTHRATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMAALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLSEIIDDCVTSEEDEEVEEEEDPEEDRKSTREEESELPKSPEPPQGPVLAPAEGPPLQALGQPSGSFICEMPNCGADCRCHVTPFLPQVFSSRQALNGHARIHGGTNQVTKARGTVPSGKQKPGSAQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGPQGLLPLDQLSLIKPIKDVDLLDDDVVQQLGGVMAEAEVVDTGLLLDDQASVLLQGDTEL", "length": 1119, "header": "tr|A0A3Q1LZA6-1|A0A3Q1LZA6_BOVIN Computationally mapped isoform of Transcriptional regulating factor 1 OS=Bos taurus OX=9913 GN=TRERF1 PE=4 SV=2 CANONICAL=E1BFC1-1" }, "locus": { "chromosome": "23", "start_pos": 15979023, "end_pos": 15939898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067547.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067547.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062650.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062650.2" } ] } }, { "isoform_ac": "E1BFC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1/entry#E1BFC1-1", "sequence": { "sequence": "MGDQQLYKTNHVAHGGENLFYQQPPLGVHGGLNHSYGNTVPGAGMDAPQASPISPHFPQDTRDGLGLAVGSKNLGQVDTSRQGGWGGHAGPGNHVQLRGNLTNSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEAPAAALPSRYQQASQQPHPGFTGGLSKPALQVGQHPSQGHLYYDYQQPLAQMPVQGGQSLQAPQMLSQHMQQLQPHQYYPPQQQTHAGQQRVSMQEMQPPPQQQIRPPQPQPQPQPRQGSMQIPQYYQSPPMIQPLPEPQQPQMHLQPSSYHRDPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQPYGHPVYQQSHLPQHQQPEDGQPKTYPGDRQAQAMLSSHGDLGPPDTGMGDAASSDLNRASSALPHRPLLSPGSIHLNNMGSQHQQLSPSAVWPQMHLPDGRAQPGSPESSGQPKGVFGEQFDAKNKLTCSICLKEFKSLPALNGHMRSHGGMRASPSLKQEEGEKAPAPPPQPQPPLPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFANSVAAAPSARDKPASSMSDDEMPVLVRMTLSPPHSPQGAAPNPPAEIPKKHQPGAAKAEEALRSAPAEKKKFRHRPEPLFIPPPPSYTPNLAASHSGATLYQSQLRSPRVLGDHLLLDPAHELPPYTPPPMLSPVRQGSGLFSNVLIAGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNLTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDVSALAQDTHRATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMAALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLSEIIDDCVTSEEDEEVEEEEDPEEDRKSTREEESELPKSPEPPQGPVLAPAEGPPLQALGQPSGSFICEMPNCGADCRCHVTPFLPQVFSSRQALNGHARIHGGTNQVTKARGTVPSGKQKPGSAQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGPQGLLPLDQLSLIKPIKDVDLLDDDVVQQLGGVMAEAEVVDTGLLLDDQASVLLQGDTEL", "length": 1221, "header": "tr|E1BFC1-1|E1BFC1_BOVIN Isoform 1 of Transcriptional regulating factor 1 OS=Bos taurus OX=9913 GN=TRERF1 PE=4 SV=4 CANONICAL=E1BFC1-1" }, "locus": { "chromosome": "23", "start_pos": 15979023, "end_pos": 15939898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020376.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020376.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020376.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020376.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 778, "start_aa": "Thr", "end_pos": 778, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr778", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BFC1", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 774, "end_pos": 776, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFC1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1221, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFC1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFC1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 503, "end_pos": 530, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" }, { "id": "PS51156", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELM2", "eco_id": "ECO_0000259", "start_pos": 790, "end_pos": 881, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC1" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 896, "end_pos": 947, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 778 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 774, "end_pos": 776 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFD8-1", "uniprot_ac": "E1BFD8", "uniprot_id": "E1BFD8_BOVIN", "mass": { "chemical_mass": 61195.0, "monoisotopic_mass": 61195.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF619", "type": "recommended", "evidence": [ { "id": "E1BFD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ] } ], "protein_names": [ { "name": "Zinc finger protein 619", "type": "synonym", "evidence": [ { "id": "E1BFD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFD8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF619", "url": "https://www.uniprot.org/uniprotkb/E1BFD8", "locus": { "chromosome": "22", "start_pos": 13310529, "end_pos": 13299832, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053485", "url": "https://www.ensembl.org/id/ENSBTAG00000053485" } ] } } ], "crossref": [ { "id": "E1BFD8", "url": "https://alphafold.ebi.ac.uk/entry/E1BFD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053485", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053485", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFD8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLGVISHSPDMVPAAFPFPKPDLIFWLERGEEPGRLDPWTLVRGEDPRGTCGGGKKTENGRQTAELRISKGPESHKLITEVLLVDVPRHPLFENSLEKLQLYDPGKKKHSKNGDFTDLPVQDHPSSTVEREEIARQLQGSRGVCMHLITKQGLPREQVFYNCGECGRYFNQHSDLHQHQRIHMDKKPYKCKERGKAFRYNSKLSRHQKIHIGEKPYSCQECGQAFNQNSHLLQHQKLHGGEKPYECKDCGKTFSYNSKLIWHQRIHTGEKPFKCKECGKAFKCNYDRVIHERIHTGEKPYECKECGKSFSSNSVLIQHQRIHTGEKPYKCKECSKAFHRSSLFLQHQRFHTGEKLYKCNECWKTFSCSSRFIVHQRIHTGEKPYECQECGKAFNQKITLVQHQRVHTGEKPYECKVCGKSFRWSTSFIHHQKLHTRKKPDRVTRPSPVKPCRPTSVLSPLSPQHARPAPATPGAPLSCPRAPLLPPSVPLFLLLPSSEMAMSSPVQVVHFFQNHASPWKSTTHSLNPLPHSL", "length": 533, "header": "tr|E1BFD8-1|E1BFD8_BOVIN Isoform 1 of Zinc finger protein 619 OS=Bos taurus OX=9913 GN=ZNF619 PE=3 SV=4 CANONICAL=E1BFD8-1" }, "isoforms": [ { "isoform_ac": "E1BFD8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFD8/entry#E1BFD8-1", "sequence": { "sequence": "MKLGVISHSPDMVPAAFPFPKPDLIFWLERGEEPGRLDPWTLVRGEDPRGTCGGGKKTENGRQTAELRISKGPESHKLITEVLLVDVPRHPLFENSLEKLQLYDPGKKKHSKNGDFTDLPVQDHPSSTVEREEIARQLQGSRGVCMHLITKQGLPREQVFYNCGECGRYFNQHSDLHQHQRIHMDKKPYKCKERGKAFRYNSKLSRHQKIHIGEKPYSCQECGQAFNQNSHLLQHQKLHGGEKPYECKDCGKTFSYNSKLIWHQRIHTGEKPFKCKECGKAFKCNYDRVIHERIHTGEKPYECKECGKSFSSNSVLIQHQRIHTGEKPYKCKECSKAFHRSSLFLQHQRFHTGEKLYKCNECWKTFSCSSRFIVHQRIHTGEKPYECQECGKAFNQKITLVQHQRVHTGEKPYECKVCGKSFRWSTSFIHHQKLHTRKKPDRVTRPSPVKPCRPTSVLSPLSPQHARPAPATPGAPLSCPRAPLLPPSVPLFLLLPSSEMAMSSPVQVVHFFQNHASPWKSTTHSLNPLPHSL", "length": 533, "header": "tr|E1BFD8-1|E1BFD8_BOVIN Isoform 1 of Zinc finger protein 619 OS=Bos taurus OX=9913 GN=ZNF619 PE=3 SV=4 CANONICAL=E1BFD8-1" }, "locus": { "chromosome": "22", "start_pos": 13310526, "end_pos": 13299832, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024707.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024707.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024707.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024707.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 472, "start_aa": "Thr", "end_pos": 472, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr472", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BFD8", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFD8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFD8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFD8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFD8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 161, "end_pos": 188, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 472 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFI1-1", "uniprot_ac": "E1BFI1", "uniprot_id": "E1BFI1_BOVIN", "mass": { "chemical_mass": 67360.0, "monoisotopic_mass": 67360.0 }, "refseq": { "ac": "XP_005212677", "name": "clathrin heavy chain linker domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212677" }, "gene_names": [ { "name": "CLHC1", "type": "recommended", "evidence": [ { "id": "E1BFI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFI1" } ] }, { "name": "C11H2orf63", "type": "synonym", "evidence": [ { "id": "XP_005212677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212677" } ] }, { "name": "CLHC1", "type": "synonym", "evidence": [ { "id": "XP_005212677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212677" } ] } ], "protein_names": [ { "name": "Clathrin heavy chain linker domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BFI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFI1/entry#names_and_taxonomy" } ] }, { "name": "clathrin heavy chain linker domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212677" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFI1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLHC1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1", "locus": { "chromosome": "11", "start_pos": 37958010, "end_pos": 37967097, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000295", "url": "https://www.ensembl.org/id/ENSBTAG00000000295" } ] } } ], "crossref": [ { "id": "E1BFI1", "url": "https://alphafold.ebi.ac.uk/entry/E1BFI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000295", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000295", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517621", "url": "https://www.ncbi.nlm.nih.gov/gene/517621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFI1", "url": "https://www.orthodb.org/?gene=E1BFI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10292:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10292:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13838", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13838", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212677", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212677", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NKN9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKN9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFI1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVQEINKHAVLPPIISGSDKEFLERMQRYIITETERVCCNEEGPADEYYIIYRNVFDKVIEYVTAYKSILTSIKKEYDTFIETIKKGQRTAFYLHGKLKVLAGEPTALVYHKKRIAQLQAKMGLIENNSSKIQLQINEMKQVRAKYDTKEEQYCTFCKDPLKPIPGMTLQESVNLDALTKYLKHLEGKYAEMEELMSKKYVPIQRKADLDEEMTVVLERRDSTENLNNELQFSHQKLQVISQALTLWVKSDMSRSFQDFVENIQKSKDLHDKQGIVEELLEEDPSKAKEAEILLYFIERFNELISLGEYEKAVYFAVNGPRRILQNIGTVNKFKAVGKIRGKPSPLLLFFEAIFSISHAFRHPVDAVLTLEGIKCGLSEKRLDLVINWVTQERLTFSEEAGDVIFDYGEQDTYNKAKCLALAQIIYSECGLHKKALLCLCKQGQIHGAMEYIQQFKDFTSDDLMQLIKSCPNIELIQCLTKEWNGKPPYLSFGLAVLHLFSVDMKKVGIKLLQEISKGGKDAVEHLLINDPFCSLEKWQEVANICLQNGFDQLSNDIMSVLRSQAGVTEISEEDDTVNLMQHVFW", "length": 586, "header": "tr|E1BFI1-1|E1BFI1_BOVIN Isoform 1 of Clathrin heavy chain linker domain-containing protein 1 OS=Bos taurus OX=9913 GN=CLHC1 PE=4 SV=3 CANONICAL=E1BFI1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NKN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1/entry#A0ABI0NKN9-1", "sequence": { "sequence": "MAVSSGNCSLHCFLFGRTTCPKMQFRTSRLRSYYRLAVGLEKGIKVIEYVTAYKSILTSIKKEYDTFIETIKKGQRTAFYLHGKLKVLAGEPTALVYHKKRIAQLQAKMGLIENNSSKIQLQINEMKQVRAKYDTKEEQYCTFCKDPLKPIPGMTLQESVNLDALTKYLKHLEGKYAEMEELMSKKYVPIQRKADLDEEMTVVLERRDSTENLNNELQFSHQKLQVISQALTLWVKSDMSRSFQDFVENIQKSKDLHDKQGIVEELLEEDPSKAKEAEILLYFIERFNELISLGEYEKAVYFAVNGPRRILQNIGTVNKFKAVGKIRGKPSPLLLFFEAIFSISHAFRHPVDAVLTLEGIKCGLSEKRLDLVINWVTQERLTFSEEAGDVIFDYGEQDTYNKAKCLALAQIIYSECGLHKKALLCLCKQGQIHGAMEYIQQFKDFTSDDLMQLIKSCPNIELIQCLTKEWNGKPPYLSFGLAVLHLFSVDMKKVGIKLLQEISKGGKDAVEHLLINDPFCSLEKWQEVANICLQNGFDQLSNDIMSVLRSQAGVTEISEEDDTVNLMQHVFW", "length": 572, "header": "tr|A0ABI0NKN9-1|A0ABI0NKN9_BOVIN Computationally mapped isoform of Clathrin heavy chain linker domain-containing protein 1 OS=Bos taurus OX=9913 GN=CLHC1 PE=4 SV=1 CANONICAL=E1BFI1-1" }, "locus": { "chromosome": "11", "start_pos": 37970177, "end_pos": 37935316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141719.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141719.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105339.1" } ] } }, { "isoform_ac": "E1BFI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFI1/entry#E1BFI1-1", "sequence": { "sequence": "MSVQEINKHAVLPPIISGSDKEFLERMQRYIITETERVCCNEEGPADEYYIIYRNVFDKVIEYVTAYKSILTSIKKEYDTFIETIKKGQRTAFYLHGKLKVLAGEPTALVYHKKRIAQLQAKMGLIENNSSKIQLQINEMKQVRAKYDTKEEQYCTFCKDPLKPIPGMTLQESVNLDALTKYLKHLEGKYAEMEELMSKKYVPIQRKADLDEEMTVVLERRDSTENLNNELQFSHQKLQVISQALTLWVKSDMSRSFQDFVENIQKSKDLHDKQGIVEELLEEDPSKAKEAEILLYFIERFNELISLGEYEKAVYFAVNGPRRILQNIGTVNKFKAVGKIRGKPSPLLLFFEAIFSISHAFRHPVDAVLTLEGIKCGLSEKRLDLVINWVTQERLTFSEEAGDVIFDYGEQDTYNKAKCLALAQIIYSECGLHKKALLCLCKQGQIHGAMEYIQQFKDFTSDDLMQLIKSCPNIELIQCLTKEWNGKPPYLSFGLAVLHLFSVDMKKVGIKLLQEISKGGKDAVEHLLINDPFCSLEKWQEVANICLQNGFDQLSNDIMSVLRSQAGVTEISEEDDTVNLMQHVFW", "length": 586, "header": "tr|E1BFI1-1|E1BFI1_BOVIN Isoform 1 of Clathrin heavy chain linker domain-containing protein 1 OS=Bos taurus OX=9913 GN=CLHC1 PE=4 SV=3 CANONICAL=E1BFI1-1" }, "locus": { "chromosome": "11", "start_pos": 37967081, "end_pos": 37935316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000369.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000369.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000369.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000369.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 586, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFI1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFI1" }, { "id": "PF15739", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15739" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Translin-associated factor X-interacting protein 1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 141, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFJ4-1", "uniprot_ac": "E1BFJ4", "uniprot_id": "E1BFJ4_BOVIN", "mass": { "chemical_mass": 188029.0, "monoisotopic_mass": 188029.0 }, "refseq": { "ac": "XP_002691915", "name": "RING finger protein 17 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691915" }, "gene_names": [ { "name": "RNF17", "type": "recommended", "evidence": [ { "id": "E1BFJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ] }, { "name": "RNF17", "type": "synonym", "evidence": [ { "id": "XP_002691915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691915" } ] } ], "protein_names": [ { "name": "RING finger protein 17", "type": "recommended", "evidence": [ { "id": "E1BFJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 17 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691915" } ] } ], "function": [ { "annotation": "Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S296", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S296#function" }, { "database": "UniProtKB", "id": "ARBA00057086", "url": "https://www.uniprot.org/uniprotkb/ARBA00057086#function" }, { "database": "UniProtKB", "id": "A0AAA9SMF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF5#function" }, { "database": "UniProtKB", "id": "A0AAA9SQW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW8#function" }, { "database": "UniProtKB", "id": "A0AAA9SRQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ5#function" }, { "database": "UniProtKB", "id": "A0AAA9T8Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q4#function" }, { "database": "UniProtKB", "id": "A0AAA9TAP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP5#function" }, { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF17", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4", "locus": { "chromosome": "12", "start_pos": 36524814, "end_pos": 36634930, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000278", "url": "https://www.ensembl.org/id/ENSBTAG00000000278" } ] } } ], "crossref": [ { "id": "E1BFJ4", "url": "https://alphafold.ebi.ac.uk/entry/E1BFJ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20414", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20414", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20415", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20415", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20417", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20417", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20418", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20418", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528075", "url": "https://www.ncbi.nlm.nih.gov/gene/528075", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528075", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528075", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BFJ4", "url": "https://www.orthodb.org/?gene=E1BFJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16442:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16442:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S296", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S296", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S296-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S296-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFJ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPVGNVWQPDAVELLQELLSKREVEIHIMELPENPWEKLSIHLYFDGMSLSYFLAHHKYCTFEQSEEIFKENPTDYNKKYEEERWEIRFEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1651, "header": "tr|E1BFJ4-1|E1BFJ4_BOVIN Isoform 1 of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=3 CANONICAL=E1BFJ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S296-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9S296-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPVGNVWQPDAVELLQELLSKREVEIHIMDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1590, "header": "tr|A0AAA9S296-1|A0AAA9S296_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079157.1" } ] } }, { "isoform_ac": "A0AAA9SMF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9SMF5-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPNPTDYNKKYEEERWEIRFEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1582, "header": "tr|A0AAA9SMF5-1|A0AAA9SMF5_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083936.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083936.1" } ] } }, { "isoform_ac": "A0AAA9SQW8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9SQW8-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPELPENPWEKLSIHLYFDGMSLSYFLAHHKYCTFEQSEEIFKENPTDYNKKYEEERWEIRFEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1624, "header": "tr|A0AAA9SQW8-1|A0AAA9SQW8_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086358.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086358.1" } ] } }, { "isoform_ac": "A0AAA9SRQ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9SRQ5-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPVGNVWQPDAVELLQELLSKREVEIHIMELPENPWEKLSIHLYFDGMSLSYFLAHHKYCTFEQSEEIFKEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1632, "header": "tr|A0AAA9SRQ5-1|A0AAA9SRQ5_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132512.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132512.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086745.1" } ] } }, { "isoform_ac": "A0AAA9T8Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9T8Q4-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1563, "header": "tr|A0AAA9T8Q4-1|A0AAA9T8Q4_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126062.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126062.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092257.1" } ] } }, { "isoform_ac": "A0AAA9TAP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9TAP5-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1524, "header": "tr|A0AAA9TAP5-1|A0AAA9TAP5_BOVIN Computationally mapped isoform of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095228.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095228.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093957.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093957.1" } ] } }, { "isoform_ac": "A0AAA9TM49-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#A0AAA9TM49-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVGNVWQPDAVELLQELLSKREVEIHIMELPENPWEKLSIHLYFDGMSLSYFLAHHKYCTFEQSEEIFKENPTDYNKKYEEERWEIRFEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1601, "header": "tr|A0AAA9TM49-1|A0AAA9TM49_BOVIN Computationally mapped isoform of Ring finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=1 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120663.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120663.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098061.1" } ] } }, { "isoform_ac": "E1BFJ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4/entry#E1BFJ4-1", "sequence": { "sequence": "MAAEALRARRPVSSCGQVETHGRARGATEAMCSRCGRRAPRALGHHHELQCGHAFCDLCLLMTEEYSTITCPDCEVATTISTKQEYCPIDGYIKEDSFMEKLPPKKMRNCSQDFEKTAHQQTISLEHSASTPRTVLNPSAVIQESKTVEEIDEALKIAGQNFEQLSIAVKMLEHMHSQTKEETVCLKEVLEKQFDQLYTSLDSRKKSLCEELARNTDNYLSKIIVTKSYIEAKKSDLDAAMKIARELKSAPSLRIYCDLNQIIRTLKLTFESDLSQVSSLKLRNSPKLNMDCSEIICMFNRMGKIEFEDSTRCDPQESEMEKNGQKKYSCKKEFSYGGTYLSLEKKKADISVLTNEAPLTSSQWENNDMHLAADFQPQKEVIAATLPKTIAALPQVGSSPDVIIEEIIEEEENLETCFTDYFAKTPRYPTKPLQKKSSVSFGSKTGSPELVFVSHVIHPCHFYIRKYSQIKDATVLERKVNQFCNKNLHLDPSDVLELGARIFINSIENGMWCRGTITELIPMGSESIRKLCSPTKFSVREVALIQIFMVDFGNSEVLIVAGVGDSHVRSEHIAKQHIILNDLCLVLRKSEPYIEELLKDVQPLAHPCSLKDIVPQNSSEGWGEEAKIEFLKMVNKKAVLMKVFKEEDGVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQTPRSHSGKNTTLHYPPPILPKEMTDVSVMVCHINSPSDFYLQLIESLDFLFLLKGIEEFYKSEDAENLEILCPVQGQACVAKFEDGVWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLNPAEKAIKCKLAYIEPYKGTVQWSKNAKEKFEEKTQDKFMTCSIIKILEDNVLLVELFDFLGAPGMIPTSINDQLVKEGLASYEVGYTLKDNSKKHIEVWDPSPEEIISNEVNNLINPLFAKSLPSEDLQSLYNKELPVHICNIVSPEKIYVQWLLTENLLHSLGEKMVATYENSKWEPVKWENDMHCAVNIPDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNINCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAVATIIIQENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRETRINKLDNSHSLSQKSLEIPQEQGESVVTKCIKINSDPDKKAAVGISEPKVTEFREKILEPRTTGCYKPPAIPNQKVFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEACAVRGSDTMWYRGKVMEVIGSTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYNTIPVGNVWQPDAVELLQELLSKREVEIHIMELPENPWEKLSIHLYFDGMSLSYFLAHHKYCTFEQSEEIFKENPTDYNKKYEEERWEIRFEDLLLPETETPILPPYLSSSLPPPEELYAVQVKHVVSPSEVYICLDSVESCSLFNQHSDTEDSGVGWESEPESLEEALRRFNKSMETFPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLAVLVQFVDYGSTEKLTVNRLRQIPLHLMQYPARAIKVLLAGFKPPLRDVGKTRIPYCPKWSMEALWAMIDCLQGKQLYASSMAQVPEQMVTLYEDKQYPIHMSLVEMGLADRDE", "length": 1651, "header": "tr|E1BFJ4-1|E1BFJ4_BOVIN Isoform 1 of RING finger protein 17 OS=Bos taurus OX=9913 GN=RNF17 PE=4 SV=3 CANONICAL=E1BFJ4-1" }, "locus": { "chromosome": "12", "start_pos": 36634779, "end_pos": 36524818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000345.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000345.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000345.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000345.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528075", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528075", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BFJ4", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1099, "end_pos": 1101, "annotation": "n_glycosylation_sequon" }, { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1100, "end_pos": 1102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1496, "end_pos": 1498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 617, "end_pos": 619, "annotation": "n_glycosylation_sequon" }, { "start_pos": 695, "end_pos": 697, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFJ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1651, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFJ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFJ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 75, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFJ4" }, { "id": "PS50304", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50304" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tudor", "eco_id": "ECO_0000259", "start_pos": 758, "end_pos": 816, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1099, "end_pos": 1101 }, { "start_pos": 109, "end_pos": 111 }, { "start_pos": 1100, "end_pos": 1102 }, { "start_pos": 1496, "end_pos": 1498 }, { "start_pos": 617, "end_pos": 619 }, { "start_pos": 695, "end_pos": 697 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFL4-1", "uniprot_ac": "E1BFL4", "uniprot_id": "E1BFL4_BOVIN", "mass": { "chemical_mass": 22448.0, "monoisotopic_mass": 22448.0 }, "refseq": { "ac": "NP_001179618", "name": "cysteine-rich protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179618" }, "gene_names": [ { "name": "CRIP3", "type": "recommended", "evidence": [ { "id": "E1BFL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFL4" } ] }, { "name": "CRIP3", "type": "synonym", "evidence": [ { "id": "NP_001179618", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179618" } ] } ], "protein_names": [ { "name": "Cysteine rich protein 3", "type": "synonym", "evidence": [ { "id": "E1BFL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFL4/entry#names_and_taxonomy" } ] }, { "name": "cysteine-rich protein 3", "type": "synonym", "evidence": [ { "id": "NP_001179618", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179618" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFL4", "url": "https://www.uniprot.org/uniprotkb/E1BFL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRIP3", "url": "https://www.uniprot.org/uniprotkb/E1BFL4", "locus": { "chromosome": "23", "start_pos": 16894619, "end_pos": 16912415, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006357", "url": "https://www.ensembl.org/id/ENSBTAG00000006357" } ] } } ], "crossref": [ { "id": "E1BFL4", "url": "https://alphafold.ebi.ac.uk/entry/E1BFL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006357", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006357", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09476", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09476", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530071", "url": "https://www.ncbi.nlm.nih.gov/gene/530071", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530071", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530071", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PRHWPKV", "url": "https://omabrowser.org/oma/group/PRHWPKV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFL4", "url": "https://www.orthodb.org/?gene=E1BFL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46074:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46074:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179618", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFL4", "url": "https://www.uniprot.org/uniprotkb/E1BFL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWTCPRCQQPVFFAEKVSSLGKNWHPFCLKCEHCHSVLSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYKPPTPTPASITHLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCEEPVYFAETVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGAPYCHIPCYGYLFGPKGVNIGDVGCYIYDPVEIKSK", "length": 204, "header": "tr|E1BFL4-1|E1BFL4_BOVIN Isoform 1 of Cysteine rich protein 3 OS=Bos taurus OX=9913 GN=CRIP3 PE=4 SV=1 CANONICAL=E1BFL4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFL4/entry#A0AAA9SWS4-1", "sequence": { "sequence": "MSWTCPRCQQPVFFAEKVSSLGKNWHPFCLKCEHCHSVLSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYKPPTPTPASITHLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCEEPVYFAETVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGAPYCHIPCYGYLFGPKGGQPHPRHPEVWHVCVDNFPCGQ", "length": 207, "header": "tr|A0AAA9SWS4-1|A0AAA9SWS4_BOVIN Computationally mapped isoform of Cysteine rich protein 3 OS=Bos taurus OX=9913 GN=CRIP3 PE=4 SV=1 CANONICAL=E1BFL4-1" }, "locus": { "chromosome": "23", "start_pos": 16902449, "end_pos": 16900083, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118528.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118528.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088515.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088515.1" } ] } }, { "isoform_ac": "A0AAA9TWC9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFL4/entry#A0AAA9TWC9-1", "sequence": { "sequence": "EPGWAGRRGERRAPSAWPGSPLPDSTLSSTAEKVSSLGKNWHPFCLKCEHCHSVLSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYKPPTPTPASITHLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCEEPVYFAETVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGAPYCHIPCYGYLFGPKGPIHSLRALPSGITMMVKPAKA", "length": 222, "header": "tr|A0AAA9TWC9-1|A0AAA9TWC9_BOVIN Computationally mapped isoform of Cysteine rich protein 3 OS=Bos taurus OX=9913 GN=CRIP3 PE=4 SV=1 CANONICAL=E1BFL4-1" }, "locus": { "chromosome": "23", "start_pos": 16902236, "end_pos": 16894621, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099867.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099867.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102930.1" } ] } }, { "isoform_ac": "E1BFL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFL4/entry#E1BFL4-1", "sequence": { "sequence": "MSWTCPRCQQPVFFAEKVSSLGKNWHPFCLKCEHCHSVLSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYKPPTPTPASITHLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCEEPVYFAETVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGAPYCHIPCYGYLFGPKGVNIGDVGCYIYDPVEIKSK", "length": 204, "header": "tr|E1BFL4-1|E1BFL4_BOVIN Isoform 1 of Cysteine rich protein 3 OS=Bos taurus OX=9913 GN=CRIP3 PE=4 SV=1 CANONICAL=E1BFL4-1" }, "locus": { "chromosome": "23", "start_pos": 16902449, "end_pos": 16899934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035993.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035993.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035859.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035859.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 83, "start_aa": "Thr", "end_pos": 83, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr83", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:530071", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530071", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IPR6-1", "protein_name": "Cysteine-rich protein 3 isoform X1", "gene_name": "Crip3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSWTCPRCQQPVYFAEKVSSLGKNWHRFCLKCEHCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGCYPYSPPAPSPASSVSLSPSNFSPPRPRAGLPQAKKSPPYTKTFTGETSMCPGCGDPVYFAEKVMSLGRNWHRPCLRCHRCRKTLTAGSHAEHDGTPYCHIPCYGYLFGPKGVNIGNVGCYIYDPVEIRSK", "length": 204 }, "evidence": [ { "id": "E1BFL4", "url": "https://omabrowser.org/oma/group/E1BFL4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZNQ0-1", "protein_name": "Cysteine-rich protein 3", "gene_name": "Crip3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSWTCPRCQQPVYFAEKVSSVGKHWHRFCLKCERCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGCYLYNPPSPPPASSISLSPSNFSPPRPRTGLPRAKKSPPYLKTFTGETSLCPGCGDPVYFAEKVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGMPYCHIPCYGYLFGPKGVNIGDVGCYIYDPVDIRPK", "length": 204 }, "evidence": [ { "id": "E1BFL4", "url": "https://omabrowser.org/oma/group/E1BFL4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q500W4-1", "protein_name": "LIM domain-containing protein PLIM2c", "gene_name": "PLIM2C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAFTGTTDKCKACDKTVYVMDLMTLEGMPYHKSCFRCSHCNGTLVICNYSSMDGVLYCKTHFEQLFKESGNFSKNFQTAGKTEKSNDATKAPNRLSSFFSGTQDKCAACKKTVYPLEKMTMEGESYHKTCFRCAHSGCPLTHSSYAALDGVLYCKVHFSQLFLEKGNYNHVLQAAANHRRSTAEEDKTEPKEDEANPTEEETSDAAAEEHES", "length": 213 }, "evidence": [ { "id": "E1BFL4", "url": "https://omabrowser.org/oma/group/E1BFL4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q6Q6R3-3", "protein_name": "Cysteine-rich protein 3", "gene_name": "Crip3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSWTCPRCQQPVYFAEKVSSLGKNWHRFCLKCERCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGCYLYNLPTPPPASRISLSPSNFSPPRPRTGLSRAKKGPPYLKTFTGETSLCPGCGDPVFFAEKVMSLGRNWHRPCLRCQRCRKTLTAGSHAEHDGMPYCHIPCYGYLFGPKGVNIGDVGCYIYDPVDIRSK", "length": 204 }, "evidence": [ { "id": "E1BFL4", "url": "https://omabrowser.org/oma/group/E1BFL4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6Q6R5-1", "protein_name": "Cysteine-rich protein 3", "gene_name": "CRIP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSWTCPRCQQPVFFAEKVSSLGKNWHRFCLKCERCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYNPPTPSPGCTTPLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCGEPVYFAEKVMSLGRNWHRPCLRCQRCHKTLTAGSHAEHDGVPYCHVPCYGYLFGPKGGQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG", "length": 217 }, "evidence": [ { "id": "E1BFL4", "url": "https://omabrowser.org/oma/group/E1BFL4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BFL4", "url": "https://www.uniprot.org/uniprotkb/E1BFL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFL4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFL4" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 64, "start_aa": "Trp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 83 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFN0-1", "uniprot_ac": "E1BFN0", "uniprot_id": "E1BFN0_BOVIN", "mass": { "chemical_mass": 45911.0, "monoisotopic_mass": 45911.0 }, "refseq": { "ac": "XP_002684875", "name": "protein FAM43A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684875" }, "gene_names": [ { "name": "FAM43A", "type": "recommended", "evidence": [ { "id": "E1BFN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN0" } ] }, { "name": "FAM43A", "type": "synonym", "evidence": [ { "id": "XP_002684875", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684875" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 43 member A", "type": "synonym", "evidence": [ { "id": "E1BFN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN0/entry#names_and_taxonomy" } ] }, { "name": "protein FAM43A", "type": "synonym", "evidence": [ { "id": "XP_002684875", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684875" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFN0", "url": "https://www.uniprot.org/uniprotkb/E1BFN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM43A", "url": "https://www.uniprot.org/uniprotkb/E1BFN0", "locus": { "chromosome": "1", "start_pos": 72756731, "end_pos": 73048634, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008462", "url": "https://www.ensembl.org/id/ENSBTAG00000008462" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008462", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008462", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539374", "url": "https://www.ncbi.nlm.nih.gov/gene/539374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539374", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539374", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMHLECG", "url": "https://omabrowser.org/oma/group/AMHLECG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFN0", "url": "https://www.orthodb.org/?gene=E1BFN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11232:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11232:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14719", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14719", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002684875", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684875", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFN0", "url": "https://www.uniprot.org/uniprotkb/E1BFN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQQEQELQEEEEEEHAEGCPEEEEDRAGEGEPAEPEAEAKRALVVAMHFECGDLLDTLESGHEEALGGGGVSPGPEAGSSPLLLGSTSDMRAELSQLINDLGELSFGNDVRSLQADLRVTRLLSGESTGSESSIEGGGPDANTATAGDPSGPADCASPDEPHSG", "length": 423, "header": "tr|E1BFN0-1|E1BFN0_BOVIN Isoform 1 of Family with sequence similarity 43 member A OS=Bos taurus OX=9913 GN=FAM43A PE=4 SV=2 CANONICAL=E1BFN0-1" }, "isoforms": [ { "isoform_ac": "E1BFN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN0/entry#E1BFN0-1", "sequence": { "sequence": "MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQQEQELQEEEEEEHAEGCPEEEEDRAGEGEPAEPEAEAKRALVVAMHFECGDLLDTLESGHEEALGGGGVSPGPEAGSSPLLLGSTSDMRAELSQLINDLGELSFGNDVRSLQADLRVTRLLSGESTGSESSIEGGGPDANTATAGDPSGPADCASPDEPHSG", "length": 423, "header": "tr|E1BFN0-1|E1BFN0_BOVIN Isoform 1 of Family with sequence similarity 43 member A OS=Bos taurus OX=9913 GN=FAM43A PE=4 SV=2 CANONICAL=E1BFN0-1" }, "locus": { "chromosome": "1", "start_pos": 72862834, "end_pos": 72861566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057417.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057417.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051061.2", "url": "https://www.ensembl.org/id/ENSBTAP00000051061.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539374", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539374", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PHW0-1", "protein_name": "Family with sequence similarity 43 member A", "gene_name": "FAM43A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPWKRSKVELVAGEARRQSKPKGYAVSVHYSALTSLARACPESALHRVGSMFRSKRRKFRVTSEDPTYTVLYLGNATTIQSKGEGCTDLAVCKIWSKSEAGRQGTKMKLTISAQGIRMAHAEDKGLRRPGHLYLLHRVTYCVADPRLPRVFAWIYRHELKHKAVMLRCHAVLVSKPEKAKAMALLLYQTSATALAEFRRLKKRDDARHQQQQLVGEQSIPLVPLRKLLNGQCCYKPPVERSRSAPKLGSITEDLLGEEQEERAMHCDCEDILEALGEPEGELLRAGAGRGEGPELGRLLRDLGELSLGNDLRSLRADLGVRRLLSGESTGSESSLESTGPDGAAPPCNGADQPPPGDPESG", "length": 362 }, "evidence": [ { "id": "E1BFN0", "url": "https://omabrowser.org/oma/group/E1BFN0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SFG1-1", "protein_name": "Family with sequence similarity 43 member A", "gene_name": "FAM43A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQQEQEQELQEEEEEEHTDGCLNEEEEDRAGEGGPAEQEAEAPQELVVAMHFECGDLLETLESSREEALGEGGVSPGPEAGPPPLLLGSASDMKAELSQLINDLGELSFGNDVRSLQADLRVTRLLSGESTGSESSIEGGGPDATTATTEDQSTDCGSPDEPLSG", "length": 424 }, "evidence": [ { "id": "E1BFN0", "url": "https://omabrowser.org/oma/group/E1BFN0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BUP8-1", "protein_name": "Protein FAM43A", "gene_name": "Fam43a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQQEEELQEEEEEHLEDCLEEEEEEDGVGDGDPAEEEAEAQRALVVAMQLECEDLLDPLENGHEEALGDGGVSLGPSSGTSLPLSVCASDMKAQLSQLISDLGDLSFGNDVSTLETDLRVTRLLSGESTGSESSIEGGGLDATPVSPGNPSGPADSTSLDEPYSG", "length": 424 }, "evidence": [ { "id": "E1BFN0", "url": "https://omabrowser.org/oma/group/E1BFN0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2R8-1", "protein_name": "Protein FAM43A", "gene_name": "FAM43A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQLEQELQEEEEEEQPEGCPEEEENRAAEGDPAEEEAEAQRALVVAMHFECGDLLDTLENGRGEALGGGGGSLGPGAGPPPLLLGSASDMKAELSQLISDLGELSFGNDVRTLQADLRVTRLLSGDSTGSESSIEGGGPDATSATAGDSSRQADGASADEPHSG", "length": 423 }, "evidence": [ { "id": "E1BFN0", "url": "https://omabrowser.org/oma/group/E1BFN0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN0" }, { "id": "SM00462", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PID", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 205, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFN4-1", "uniprot_ac": "E1BFN4", "uniprot_id": "E1BFN4_BOVIN", "mass": { "chemical_mass": 23944.0, "monoisotopic_mass": 23944.0 }, "refseq": {}, "gene_names": [ { "name": "SPATA24", "type": "recommended", "evidence": [ { "id": "E1BFN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN4" } ] } ], "protein_names": [ { "name": "Spermatosis associated 24", "type": "synonym", "evidence": [ { "id": "E1BFN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFN4", "url": "https://www.uniprot.org/uniprotkb/E1BFN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA24", "url": "https://www.uniprot.org/uniprotkb/E1BFN4", "locus": { "chromosome": "7", "start_pos": 50670065, "end_pos": 50675970, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017957", "url": "https://www.ensembl.org/id/ENSBTAG00000017957" } ] } } ], "crossref": [ { "id": "E1BFN4", "url": "https://alphafold.ebi.ac.uk/entry/E1BFN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017957", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017957", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFN4", "url": "https://www.orthodb.org/?gene=E1BFN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35155:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35155:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BFN4", "url": "https://www.uniprot.org/uniprotkb/E1BFN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATPVGWSQGGSGSVCLAFDQLRDVIESQEELIHQLRNVMILQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSRALQESSKKDQLITKCNGITCLTSGSRSSKRTTWPKCWTRSIRKPRGRVRPGAVSVPGKNKMVVAFLLSAVKPNLCLLCSGGPHPDPVPVGTSLRPHSGLDPREEAG", "length": 218, "header": "tr|E1BFN4-1|E1BFN4_BOVIN Isoform 1 of Spermatosis associated 24 OS=Bos taurus OX=9913 GN=SPATA24 PE=4 SV=4 CANONICAL=E1BFN4-1" }, "isoforms": [ { "isoform_ac": "E1BFN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN4/entry#E1BFN4-1", "sequence": { "sequence": "MATPVGWSQGGSGSVCLAFDQLRDVIESQEELIHQLRNVMILQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSRALQESSKKDQLITKCNGITCLTSGSRSSKRTTWPKCWTRSIRKPRGRVRPGAVSVPGKNKMVVAFLLSAVKPNLCLLCSGGPHPDPVPVGTSLRPHSGLDPREEAG", "length": 218, "header": "tr|E1BFN4-1|E1BFN4_BOVIN Isoform 1 of Spermatosis associated 24 OS=Bos taurus OX=9913 GN=SPATA24 PE=4 SV=4 CANONICAL=E1BFN4-1" }, "locus": { "chromosome": "7", "start_pos": 50675951, "end_pos": 50671069, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023876.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023876.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023876.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023876.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BFN4", "url": "https://www.uniprot.org/uniprotkb/E1BFN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFN4", "url": "https://www.uniprot.org/uniprotkb/E1BFN4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFN4", "url": "https://www.uniprot.org/uniprotkb/E1BFN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFQ5-1", "uniprot_ac": "E1BFQ5", "uniprot_id": "E1BFQ5_BOVIN", "mass": { "chemical_mass": 37923.0, "monoisotopic_mass": 37923.0 }, "refseq": { "ac": "XP_002695862", "name": "leucine-rich repeat-containing protein 75A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695862" }, "gene_names": [ { "name": "LRRC75A", "type": "recommended", "evidence": [ { "id": "E1BFQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ] }, { "name": "LRRC75A", "type": "synonym", "evidence": [ { "id": "XP_002695862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695862" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 75A", "type": "synonym", "evidence": [ { "id": "E1BFQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 75A", "type": "synonym", "evidence": [ { "id": "XP_002695862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695862" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC75A", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5", "locus": { "chromosome": "19", "start_pos": 33209225, "end_pos": 33175049, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025078", "url": "https://www.ensembl.org/id/ENSBTAG00000025078" } ] } } ], "crossref": [ { "id": "E1BFQ5", "url": "https://alphafold.ebi.ac.uk/entry/E1BFQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509555", "url": "https://www.ncbi.nlm.nih.gov/gene/509555", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509555", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509555", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NPPDNTV", "url": "https://omabrowser.org/oma/group/NPPDNTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFQ5", "url": "https://www.orthodb.org/?gene=E1BFQ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR39654", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39654", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39654:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39654:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002695862", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695862", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFQ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTRQTKGSLAERAGPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGAGLPPYHRRVGMVQELLRMLHQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRMTTLALNGNRLTRALLRDLTDALRDPRKFPSVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGSGHETQDETLGPEDPGGGPETPARDQEGRETVGATQT", "length": 345, "header": "tr|E1BFQ5-1|E1BFQ5_BOVIN Isoform 1 of Leucine rich repeat containing 75A OS=Bos taurus OX=9913 GN=LRRC75A PE=3 SV=3 CANONICAL=E1BFQ5-1" }, "isoforms": [ { "isoform_ac": "E1BFQ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5/entry#E1BFQ5-1", "sequence": { "sequence": "MGTRQTKGSLAERAGPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGAGLPPYHRRVGMVQELLRMLHQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRMTTLALNGNRLTRALLRDLTDALRDPRKFPSVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGSGHETQDETLGPEDPGGGPETPARDQEGRETVGATQT", "length": 345, "header": "tr|E1BFQ5-1|E1BFQ5_BOVIN Isoform 1 of Leucine rich repeat containing 75A OS=Bos taurus OX=9913 GN=LRRC75A PE=3 SV=3 CANONICAL=E1BFQ5-1" }, "locus": { "chromosome": "19", "start_pos": 33208221, "end_pos": 33175247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035050.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035050.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034930.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034930.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509555", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509555", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZS41-1", "protein_name": "Leucine rich repeat containing 75A", "gene_name": "LRRC75A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGLPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPQDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTRALLRDLTDALKDPSKFPSVTWIDLGNNVDIFSLPQPFLLSLRKRCPKQGHLPTILELGEGPGCGDEARDETVGQEDPGGDPGAPTRAQESRETGGAAQT", "length": 343 }, "evidence": [ { "id": "E1BFQ5", "url": "https://omabrowser.org/oma/group/E1BFQ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1ALM7-1", "protein_name": "Leucine rich repeat containing 75A", "gene_name": "LRRC75A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTKQTKGCQPGSTGESPPAHHRKKTSPRERGDFLASLVAKSGEKFGKGAGSLPPYHRRICMIQDMLGLVKQGKQEEATELLRHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDNIGAMEKLCRQLTYHLSPHSQWRRQGIMKRKPQSCLKAVLMGKPQDNTVDLSGIPLTLKDLERVTSYLQHSSEHIDTVELCFTELTDEMLLQLLPALCGLPHLTTLSLNGNRLTKAILRDLTETLKDPKKFPSVTWIDLGNNVDIFSLPQPFLVSLKRRCPKQGNLPTILEFGEGQVSDLENQDGLAESQEDLRGEKGEGTPLGKAEGRTVEEQGAGMPQT", "length": 354 }, "evidence": [ { "id": "E1BFQ5", "url": "https://omabrowser.org/oma/group/E1BFQ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7TSF4-1", "protein_name": "Leucine-rich repeat-containing protein 75A", "gene_name": "Lrrc75a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRAGSGLPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDAMGAMEKLCRQLTYHLSPHSQWRRHRGLKRKPQACLKALLSGNPPDNMVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTRALLRDLTDTLKDPSKFPNVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGTGEEAREGTDQQDPIGSPVTPARGQESTECVIQT", "length": 339 }, "evidence": [ { "id": "E1BFQ5", "url": "https://omabrowser.org/oma/group/E1BFQ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NAA5-1", "protein_name": "Leucine-rich repeat-containing protein 75A", "gene_name": "LRRC75A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGMPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTRAVLRDLTDILKDPSKFPNVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGSGEEVREGTVGQEDPGGGPVAPAEDHHEGKETVAAAQT", "length": 344 }, "evidence": [ { "id": "E1BFQ5", "url": "https://omabrowser.org/oma/group/E1BFQ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ], "pmid": "" }, { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BFQ5", "url": "https://www.uniprot.org/uniprotkb/E1BFQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFQ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFQ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFQ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFQ7-1", "uniprot_ac": "E1BFQ7", "uniprot_id": "E1BFQ7_BOVIN", "mass": { "chemical_mass": 26889.0, "monoisotopic_mass": 26889.0 }, "refseq": { "ac": "XP_024848383", "name": "uncharacterized protein C12orf60 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848383" }, "gene_names": [ { "name": "C5H12orf60", "type": "recommended", "evidence": [ { "id": "E1BFQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7" } ] }, { "name": "C5H12orf60", "type": "synonym", "evidence": [ { "id": "XP_024848383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848383" } ] } ], "protein_names": [ { "name": "Chromosome 5 C12orf60 homolog", "type": "synonym", "evidence": [ { "id": "E1BFQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C12orf60 homolog", "type": "synonym", "evidence": [ { "id": "XP_024848383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848383" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFQ7", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C5H12orf60", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7", "locus": { "chromosome": "5", "start_pos": 95072666, "end_pos": 95104547, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008351", "url": "https://www.ensembl.org/id/ENSBTAG00000008351" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008351", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008351", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781903", "url": "https://www.ncbi.nlm.nih.gov/gene/781903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781903", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MKFPIMN", "url": "https://omabrowser.org/oma/group/MKFPIMN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFQ7", "url": "https://www.orthodb.org/?gene=E1BFQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36289:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36289:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848383", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848383", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFQ7", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFQ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSESEKDKERFIQAAKTFFFHMQDLASFTNALTKLFNSSMSTQILLMTVKEDGNVKNVFEQMLRIFKEMQSVVAAKQDPMQSEPLSSKIATAMFSMVEKSNNIRELQQSTKEMFKNVQSPIIASVLNSGNILESLESSLLLLMKYPIMNLQLSDFYRKEQSDATTSEKSPGPSKATTIDALKKLQDVLNIENAKYTIKSAADQMEQIVKTMGPILEVLQKAIKAMETKFSVFKKPRN", "length": 238, "header": "tr|E1BFQ7-1|E1BFQ7_BOVIN Isoform 1 of Chromosome 5 C12orf60 homolog OS=Bos taurus OX=9913 GN=C5H12orf60 PE=4 SV=2 CANONICAL=E1BFQ7-1" }, "isoforms": [ { "isoform_ac": "E1BFQ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BFQ7/entry#E1BFQ7-1", "sequence": { "sequence": "MSSESEKDKERFIQAAKTFFFHMQDLASFTNALTKLFNSSMSTQILLMTVKEDGNVKNVFEQMLRIFKEMQSVVAAKQDPMQSEPLSSKIATAMFSMVEKSNNIRELQQSTKEMFKNVQSPIIASVLNSGNILESLESSLLLLMKYPIMNLQLSDFYRKEQSDATTSEKSPGPSKATTIDALKKLQDVLNIENAKYTIKSAADQMEQIVKTMGPILEVLQKAIKAMETKFSVFKKPRN", "length": 238, "header": "tr|E1BFQ7-1|E1BFQ7_BOVIN Isoform 1 of Chromosome 5 C12orf60 homolog OS=Bos taurus OX=9913 GN=C5H12orf60 PE=4 SV=2 CANONICAL=E1BFQ7-1" }, "locus": { "chromosome": "5", "start_pos": 95086643, "end_pos": 95085930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079505.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781903", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4KLZ4-1", "protein_name": "Uncharacterized protein C12orf60 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSESEKGQERLIQAAKLFSCHIQDLVSFINRFIELFNLTMKTQILPMSLNEESCIKDFLEQMIENFKEMQLMADVKQKEMQKEPLCSKVVTEVTSAGGKCADLSPHHMAEEMLKTIQTSGAALVPKTSHILGSLETSLSLLMQFPIMGLRLSDFHSEETKEQPDATTSEKSRSPECPKTTKEEALKRLQDMLCPENAHKPLETAAEELEQFIKTMDMTLQVLRKSIKTMEGNSCVLTQVQGK", "length": 243 }, "evidence": [ { "id": "E1BFQ7", "url": "https://omabrowser.org/oma/group/E1BFQ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5U649-1", "protein_name": "Uncharacterized protein C12orf60", "gene_name": "C12orf60", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSESEKDKERLIQAAKMFFFHVQDLASVINTLTELFSRSMNTQILLMAVKNNSYIKDFFEQMLKIFKEMQSVVDARHDKIQKESLCSKVAMAMCSVVQKSTNVEELHQSAKEVFKSAHTPVIISVLNSSNILGSLESSLSHLMKFPIMNLQLSDFYTEDTKEQSDVTTSERTRSPPGSSKTTMIDTLKKLQDVLKTEDSKNPTKSAADLLEQIVKAMGPILEILQKAIKTMEMNISVFKKASDK", "length": 245 }, "evidence": [ { "id": "E1BFQ7", "url": "https://omabrowser.org/oma/group/E1BFQ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q810N5-1", "protein_name": "Uncharacterized protein C12orf60 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSESEKDKERLIQAAKLFFFHIRDLVSFINRFVELFNLTMKTQILPMNLNEESCIKDFFEQMIRNFKEMQLMVDGKHKQMQKEPLCSKVLTAMTSAVEKCATIAPHHTAEDMLRNIQTSGAALVLKTSHVLVNLETSLSLLMQFPIMGLRLSDLYREETKEQSDATSDATTSEKNKSPECPKATTEETLRKLQDVLSPENAHTPVEAAADELEQFVKSMEITLQVLQKSIKTMEGDIFVLTQVQGK", "length": 247 }, "evidence": [ { "id": "E1BFQ7", "url": "https://omabrowser.org/oma/group/E1BFQ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFS3-1", "uniprot_ac": "E1BFS3", "uniprot_id": "E1BFS3_BOVIN", "mass": { "chemical_mass": 37211.0, "monoisotopic_mass": 37211.0 }, "refseq": {}, "gene_names": [ { "name": "SRRD", "type": "recommended", "evidence": [ { "id": "E1BFS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFS3" } ] } ], "protein_names": [ { "name": "SRR1 domain containing", "type": "synonym", "evidence": [ { "id": "E1BFS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFS3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFS3", "url": "https://www.uniprot.org/uniprotkb/E1BFS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRRD", "url": "https://www.uniprot.org/uniprotkb/E1BFS3", "locus": { "chromosome": "17", "start_pos": 66165494, "end_pos": 66140628, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012277", "url": "https://www.ensembl.org/id/ENSBTAG00000012277" } ] } } ], "crossref": [ { "id": "E1BFS3", "url": "https://alphafold.ebi.ac.uk/entry/E1BFS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012277", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012277", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR012942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFS3", "url": "https://www.orthodb.org/?gene=E1BFS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28626", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28626", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28626:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28626:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07985", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07985", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BFS3", "url": "https://www.uniprot.org/uniprotkb/E1BFS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BFS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AAAAAAAAAATRETWRAASPRRRRSAARRPKRREAAAAAGTPGAEPEVDGGVVLRRIQEAREDLVISDFWSSALGPALSETITGCLRKHLEQLRAPEGSLSEALGHLHLDAPPVEADATPGSVPEETLVPGTCCFKCVCYGVGKFASCVIARSQLAFLLLLLERCQIPRSHCCVYDPLFSRLEIAVLNALGVVVLGDNEEGKRSVCGEPTIFYMPHCGTALYNNLLWRNWSVDALSKVVIIGNSFGGLEERLLTRILHKHYPYVAKILTGLEELAFPQTPRYMDVFNDTSLHWFPVQKLTQLPTDTWAFREEPDYQDCEDLEIIRKKTEPPCADLSSL", "length": 338, "header": "tr|E1BFS3-1|E1BFS3_BOVIN Isoform 1 of SRR1 domain containing OS=Bos taurus OX=9913 GN=SRRD PE=3 SV=4 CANONICAL=E1BFS3-1" }, "isoforms": [ { "isoform_ac": "E1BFS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BFS3/entry#E1BFS3-1", "sequence": { "sequence": "AAAAAAAAAATRETWRAASPRRRRSAARRPKRREAAAAAGTPGAEPEVDGGVVLRRIQEAREDLVISDFWSSALGPALSETITGCLRKHLEQLRAPEGSLSEALGHLHLDAPPVEADATPGSVPEETLVPGTCCFKCVCYGVGKFASCVIARSQLAFLLLLLERCQIPRSHCCVYDPLFSRLEIAVLNALGVVVLGDNEEGKRSVCGEPTIFYMPHCGTALYNNLLWRNWSVDALSKVVIIGNSFGGLEERLLTRILHKHYPYVAKILTGLEELAFPQTPRYMDVFNDTSLHWFPVQKLTQLPTDTWAFREEPDYQDCEDLEIIRKKTEPPCADLSSL", "length": 338, "header": "tr|E1BFS3-1|E1BFS3_BOVIN Isoform 1 of SRR1 domain containing OS=Bos taurus OX=9913 GN=SRRD PE=3 SV=4 CANONICAL=E1BFS3-1" }, "locus": { "chromosome": "17", "start_pos": 66164490, "end_pos": 66140629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016280.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016280.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016280.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016280.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 119, "start_aa": "Thr", "end_pos": 119, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr119", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFS3", "url": "https://www.uniprot.org/uniprotkb/E1BFS3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFS3", "url": "https://www.uniprot.org/uniprotkb/E1BFS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 338, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFS3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFS3" }, { "id": "PF07985", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07985" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SRR1-like", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 293, "start_aa": "Lys", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41, 119 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 }, { "start_pos": 287, "end_pos": 289 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFT8-1", "uniprot_ac": "E1BFT8", "uniprot_id": "E1BFT8_BOVIN", "mass": { "chemical_mass": 53271.0, "monoisotopic_mass": 53271.0 }, "refseq": {}, "gene_names": [ { "name": "WDR88", "type": "recommended", "evidence": [ { "id": "E1BFT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFT8" } ] } ], "protein_names": [ { "name": "WD repeat domain 88", "type": "synonym", "evidence": [ { "id": "E1BFT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFT8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFT8", "url": "https://www.uniprot.org/uniprotkb/E1BFT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR88", "url": "https://www.uniprot.org/uniprotkb/E1BFT8", "locus": { "chromosome": "18", "start_pos": 43594228, "end_pos": 43545772, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031810", "url": "https://www.ensembl.org/id/ENSBTAG00000031810" } ] } } ], "crossref": [ { "id": "E1BFT8", "url": "https://alphafold.ebi.ac.uk/entry/E1BFT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031810", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031810", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFT8", "url": "https://www.orthodb.org/?gene=E1BFT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45048:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45048:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BFT8", "url": "https://www.uniprot.org/uniprotkb/E1BFT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFT8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQSSGTAPHQKSNLPLSLLHIRDVTHRRPSNLPWVDVVRACGRFRLSLLQARRSRLLPSLNPLAVGDESPPPDTLWMPWMTQKALWGDQEPLSKIPFKIMRGHEHIVSSCNFCVDDTKVLSGSYDCTVKLWDAMDGSIVRDFEPVPEGPVLECSITADSRRIVAASYDKTVRAWDVETGKLLWKLSHETFIVSAKCSPDGKYVVLGLDVDHGIFIIDAKDSTTVSRIKDHHMMSLTACCFDPDSQRVASVSFDRSIKIWDVTSQTTLLTITKAHNNAISNCCFTFSGHFLCTSSWDKTLKIWNVHTGEFRNRGACVTLMQGHEGCVSSCRFARDTSFLVSGGFDKTVAIWDVEEGYRKLSLKGHNDWVMDVSISNNKKWILSASKDRTVRLWNIEEIDQIPLVIEHKKTRGLKVKQCEECDSPFSIYESDIFSETVTKCVLCRMNETDLSTEASHSSEGEASLSRESSPDEDG", "length": 475, "header": "tr|E1BFT8-1|E1BFT8_BOVIN Isoform 1 of WD repeat domain 88 OS=Bos taurus OX=9913 GN=WDR88 PE=4 SV=3 CANONICAL=E1BFT8-1" }, "isoforms": [ { "isoform_ac": "E1BFT8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFT8/entry#E1BFT8-1", "sequence": { "sequence": "MASQSSGTAPHQKSNLPLSLLHIRDVTHRRPSNLPWVDVVRACGRFRLSLLQARRSRLLPSLNPLAVGDESPPPDTLWMPWMTQKALWGDQEPLSKIPFKIMRGHEHIVSSCNFCVDDTKVLSGSYDCTVKLWDAMDGSIVRDFEPVPEGPVLECSITADSRRIVAASYDKTVRAWDVETGKLLWKLSHETFIVSAKCSPDGKYVVLGLDVDHGIFIIDAKDSTTVSRIKDHHMMSLTACCFDPDSQRVASVSFDRSIKIWDVTSQTTLLTITKAHNNAISNCCFTFSGHFLCTSSWDKTLKIWNVHTGEFRNRGACVTLMQGHEGCVSSCRFARDTSFLVSGGFDKTVAIWDVEEGYRKLSLKGHNDWVMDVSISNNKKWILSASKDRTVRLWNIEEIDQIPLVIEHKKTRGLKVKQCEECDSPFSIYESDIFSETVTKCVLCRMNETDLSTEASHSSEGEASLSRESSPDEDG", "length": 475, "header": "tr|E1BFT8-1|E1BFT8_BOVIN Isoform 1 of WD repeat domain 88 OS=Bos taurus OX=9913 GN=WDR88 PE=4 SV=3 CANONICAL=E1BFT8-1" }, "locus": { "chromosome": "18", "start_pos": 43593999, "end_pos": 43545772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045099.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045099.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042513.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042513.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFT8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 475, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFT8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFT8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 447, "end_pos": 449 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFT9-1", "uniprot_ac": "E1BFT9", "uniprot_id": "E1BFT9_BOVIN", "mass": { "chemical_mass": 71991.0, "monoisotopic_mass": 71991.0 }, "refseq": { "ac": "NP_001193158", "name": "ankyrin repeat and SAM domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193158" }, "gene_names": [ { "name": "ANKS3", "type": "recommended", "evidence": [ { "id": "E1BFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFT9" } ] }, { "name": "ANKS3", "type": "synonym", "evidence": [ { "id": "NP_001193158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193158" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and sterile alpha motif domain containing 3", "type": "synonym", "evidence": [ { "id": "E1BFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFT9/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SAM domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001193158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193158" } ] } ], "function": [ { "annotation": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.", "evidence": [ { "database": "UniProtKB", "id": "E1BFT9", "url": "https://www.uniprot.org/uniprotkb/E1BFT9#function" }, { "database": "UniProtKB", "id": "ARBA00025297", "url": "https://www.uniprot.org/uniprotkb/ARBA00025297#function" }, { "database": "UniProtKB", "id": "A0AAA9SN78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN78#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFT9", "url": "https://www.uniprot.org/uniprotkb/E1BFT9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKS3", "url": "https://www.uniprot.org/uniprotkb/E1BFT9", "locus": { "chromosome": "25", "start_pos": 3805102, "end_pos": 3820248, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006593", "url": "https://www.ensembl.org/id/ENSBTAG00000006593" } ] } } ], "crossref": [ { "id": "E1BFT9", "url": "https://alphafold.ebi.ac.uk/entry/E1BFT9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006593", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09519", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09519", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528545", "url": "https://www.ncbi.nlm.nih.gov/gene/528545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKDVHTQ", "url": "https://omabrowser.org/oma/group/RKDVHTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFT9", "url": "https://www.orthodb.org/?gene=E1BFT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24184:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24184:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193158", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SN78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFT9", "url": "https://www.uniprot.org/uniprotkb/E1BFT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFT9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFT9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWHGLGTQVGREELAVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLDSGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVGLIDAHSPSLPKSLYRSPEKYEDLSSSDECGPVPQRQRPCRKKGLSIHEGPRALARITAIGLGGRVQQPCYEQVPPRGYVSFNSSDEHPLEGGGLCYRDVTSPINERDVESSSSSSREEQAFSANPVARSSSSEGLARAPGLSSEASLESNEDSDHVRRSSVRKQTKSYVKTKNRYSSNDSQWAPSAVTSCALGASPQTDRPPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKRCEEVEAMRGLVSQEQELRAVVESCLLEQDSARKDVRAQLQEARVLAQDAALVLDQLRACQAELSARVRRDEFLREAPLCPGLPAADPKGWQASLQALSLPELSGALEERVQEMGRVLCSVTQSLEKLQALSGKESWREP", "length": 655, "header": "tr|E1BFT9-1|E1BFT9_BOVIN Isoform 1 of Ankyrin repeat and sterile alpha motif domain containing 3 OS=Bos taurus OX=9913 GN=ANKS3 PE=4 SV=1 CANONICAL=E1BFT9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN78-1", "url": "https://www.uniprot.org/uniprotkb/E1BFT9/entry#A0AAA9SN78-1", "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWHGLGTQVGREELAVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLDSGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVGLIDAHSPSLPKSLYRSPEKYEDLSSSDECGPVPQRQRPCRKKGLSIHEGPRALARITAIGLGGRVQQPCYEQVPPRGYVSFNSSDEHPLEGGGLCYRDVTSPINERDVESSSSSSREEQAFSANPVARSSSSEGLARAPGLSSEASLESNEDSDHVRRSSVRKQTKSYVKTKNRYSSNDSQWAPSAVTSCALGASPQTDRPPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKRCEEVEAMRGLVSQEQELRAVVESCLLEQDSARKDVRAQLQEARVLAQDAALVLDQLRACQAELSARVRRDEFLREAPLCPGLPAADPKGWQASLQALSLPELSGALEERVQEMGESRVCSPLAMRSTLPTPQLVKP", "length": 652, "header": "tr|A0AAA9SN78-1|A0AAA9SN78_BOVIN Computationally mapped isoform of Ankyrin repeat and sterile alpha motif domain containing 3 OS=Bos taurus OX=9913 GN=ANKS3 PE=4 SV=1 CANONICAL=E1BFT9-1" }, "locus": { "chromosome": "25", "start_pos": 3819108, "end_pos": 3806106, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084290.1" } ] } }, { "isoform_ac": "E1BFT9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFT9/entry#E1BFT9-1", "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWHGLGTQVGREELAVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLDSGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVGLIDAHSPSLPKSLYRSPEKYEDLSSSDECGPVPQRQRPCRKKGLSIHEGPRALARITAIGLGGRVQQPCYEQVPPRGYVSFNSSDEHPLEGGGLCYRDVTSPINERDVESSSSSSREEQAFSANPVARSSSSEGLARAPGLSSEASLESNEDSDHVRRSSVRKQTKSYVKTKNRYSSNDSQWAPSAVTSCALGASPQTDRPPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKRCEEVEAMRGLVSQEQELRAVVESCLLEQDSARKDVRAQLQEARVLAQDAALVLDQLRACQAELSARVRRDEFLREAPLCPGLPAADPKGWQASLQALSLPELSGALEERVQEMGRVLCSVTQSLEKLQALSGKESWREP", "length": 655, "header": "tr|E1BFT9-1|E1BFT9_BOVIN Isoform 1 of Ankyrin repeat and sterile alpha motif domain containing 3 OS=Bos taurus OX=9913 GN=ANKS3 PE=4 SV=1 CANONICAL=E1BFT9-1" }, "locus": { "chromosome": "25", "start_pos": 3819108, "end_pos": 3806006, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008660.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008660.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008660.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008660.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528545", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YXV5-1", "protein_name": "Ankyrin repeat and sterile alpha motif domain containing 3", "gene_name": "ANKS3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSELSDEASESELLSRSLSMWHGVGQMLCREELDVPLDLHTASSIGQYEVVQECIQCGDVDLNKKNCGGWTPLMYASYIGHDTIVHLLLEAGVNVNIPTPEGQTPLMLASSCGNESVAYFLLQQGAELEMKDIHGWTALFHCTSAGHQQMVKFLLDNGANANCKEPVYGYTPLMEAAASGHEIIVQYLLNHGVKADARDNTGATARTLAMKYGHTKIVGLIDLHAAPVPKVFCRDPGKYEELSSSDESCSAPQRQRPVRRTKGPSIHDGPQALAKITAVGIGGKKQSRYEQVLPQGYVTFSDDGSCEADDIRNRDVTSPINEQDVESSSSREDNVFFTNNLAAIRSSSSSSECLTRALGVSSEGSLESNEDSDHAGSPPSRKQAKSFKVKNRYSNSDGQWTHCPGKAGASSQHLIFPESPAYTGPQDLATFLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSNARPPSDALELAYADRLEAEMQELAIQLHKRCEEVEVMKGQVSQEQKLRAVAESCLMERDETWNAVQCRLREAQTITKDAGVLLDQIKSCQAELSSRLTQEQAAGRVLDSKGQLGTAREGWPLSLKSLSLPELSAVLEKCVGEMGKALQMVTQNLQRLQAPGQGAQSWLEP", "length": 656 }, "evidence": [ { "id": "E1BFT9", "url": "https://omabrowser.org/oma/group/E1BFT9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7G979-1", "protein_name": "Ankyrin repeat and SAM domain-containing protein 3 isoform X1", "gene_name": "Anks3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWYGLGAQVSREELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLDSGANANVREPVCGFTPLMEAAASGHEIIVQYFLNHGVKVDIRDHSGATARMLARQYGHMKIVALMDTHSPALPKSLYRSPEKYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALAKITAIGLGGKPQTSYEQVPPRGYVTFTSSDENTLEVEGLCYRDVTSPINERDVESSSSSSREEPTFCASPGPVWRSSSSDGLARRAQGLSSEASIESDEDSDHTRKSLVRRQTKSYLKSKSRYSNSDNQWPSSTGTTCTPGFEPQAEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQSLAKDAALVLDQLRACQAELSARVRQDQSPSEATLSPPFLSADSKGWPSPLQALSLPELSGALEDCVHEMGIMLCNTEPGEATDAEWEEMAGTVARRDDSDVG", "length": 664 }, "evidence": [ { "id": "E1BFT9", "url": "https://omabrowser.org/oma/group/E1BFT9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5M9H0-1", "protein_name": "Ankyrin repeat and SAM domain-containing protein 3", "gene_name": "Anks3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWHGLGAQVSREELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLESGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVALMETHSPVLPKSLYRSSENYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALARITATGLGGKTPDSYEQVPPRGYVTFTSSDENTMEGEGLCYRDVTSPINERDVESSSSSSREEPTFCASLGPVWRSSSSDGLARAQGLSSEASIESNEDSDHARKSSVRKQTRTYLKNKSRHNNSDGHWPSSTGTARTPGSEPQAEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQTLAQDAALVLDQLRACQAELSARLKQHHSPSEATQNPPFLPADSKGWPIPLQALSLPELSGALEDRVHEMGIMLRNAEPGETTDAEWEEMEGTIARRDDSDVG", "length": 663 }, "evidence": [ { "id": "E1BFT9", "url": "https://omabrowser.org/oma/group/E1BFT9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZW76-1", "protein_name": "Ankyrin repeat and SAM domain-containing protein 3", "gene_name": "ANKS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQRAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAVPPADSKGWQASLQAMSLPELSGALEDRVREMGQALCLVTQSLEKLQVLNGKKWRET", "length": 656 }, "evidence": [ { "id": "E1BFT9", "url": "https://omabrowser.org/oma/group/E1BFT9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZK6-1", "protein_name": "Ankyrin repeat and SAM domain-containing protein 3", "gene_name": "Anks3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSELSDEASEPELLKRSLSMWHGLGAQGSPEELDVPLDLHTAASIGQHEVVKECVQRGELDLNKKNGGGWTALMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIHGWTALFHCTSAGHQQMVKFLLESGANANVREPVYGYTPLMEAAASGHEIIVQYFLNHGVKVDTRDHSGATACMLARQFGHMKIVALMETHSPVLPKSLYRSPEKYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALAKITAIGLGGKTQTTYEQVPPRGYVTFTSSDENTMESEGLCYRDVTSPINEQDVESSSSSSREEPTFCASLGPVWRSSSSDGLARAQGLSSEASIESNEDSDHARKSSVRKQTRSYLKNKSRHGNSDGHWPSSTGPASIPGSEPQTEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDIDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLETEMQELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQTLAQDAALVLDQLRACQAELSARLRQHHSPREGTPNPHFLSADSKGWPIPLQALSLPELSGALEDRVHEMGQALCSVTQSLEKLQMLNAKKWREP", "length": 655 }, "evidence": [ { "id": "E1BFT9", "url": "https://omabrowser.org/oma/group/E1BFT9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BFT9", "url": "https://www.uniprot.org/uniprotkb/E1BFT9" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1BFT9", "url": "https://www.uniprot.org/uniprotkb/E1BFT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFT9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 655, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFT9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFT9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 301, "end_pos": 303 }, { "start_pos": 397, "end_pos": 399 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFU6-1", "uniprot_ac": "E1BFU6", "uniprot_id": "E1BFU6_BOVIN", "mass": { "chemical_mass": 21230.0, "monoisotopic_mass": 21230.0 }, "refseq": { "ac": "XP_010812426", "name": "LHFPL tetraspan subfamily member 7 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812426" }, "gene_names": [ { "name": "LHFPL7", "type": "recommended", "evidence": [ { "id": "E1BFU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFU6" } ] }, { "name": "LHFPL7", "type": "synonym", "evidence": [ { "id": "XP_010812426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812426" } ] } ], "protein_names": [ { "name": "LHFPL tetraspan subfamily member 7 protein", "type": "synonym", "evidence": [ { "id": "XP_010812426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812426" } ] }, { "name": "LHFPL tetraspan subfamily member 7", "type": "synonym", "evidence": [ { "id": "E1BFU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFU6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFU6", "url": "https://www.uniprot.org/uniprotkb/E1BFU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LHFPL7", "url": "https://www.uniprot.org/uniprotkb/E1BFU6", "locus": { "chromosome": "17", "start_pos": 65089390, "end_pos": 65098564, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006594", "url": "https://www.ensembl.org/id/ENSBTAG00000006594" } ] } } ], "crossref": [ { "id": "E1BFU6", "url": "https://alphafold.ebi.ac.uk/entry/E1BFU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006594", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006594", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540200", "url": "https://www.ncbi.nlm.nih.gov/gene/540200", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540200", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540200", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FAKEACG", "url": "https://omabrowser.org/oma/group/FAKEACG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFU6", "url": "https://www.orthodb.org/?gene=E1BFU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12489:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12489:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010812426", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFU6", "url": "https://www.uniprot.org/uniprotkb/E1BFU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BFU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGSVWAALGLSLTCISAISLVSPAWFQTTTFSFGVLTYCSWPQGDSWNQSCGTFQSLDDIPDFAWKVSAAMLLGGWLLLAFSAILLLSWALAPKGLCPRRGSGPVPGVQAAAAIATIMGLLVFPVSLASPFAKEACVASSMYHGGQCQLGWGYVTAILNAVLASLLPVITRPHVTEVQRRTIFFSSDTESIILVPETTK", "length": 200, "header": "tr|E1BFU6-1|E1BFU6_BOVIN Isoform 1 of LHFPL tetraspan subfamily member 7 OS=Bos taurus OX=9913 GN=LHFPL7 PE=4 SV=2 CANONICAL=E1BFU6-1" }, "isoforms": [ { "isoform_ac": "E1BFU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BFU6/entry#E1BFU6-1", "sequence": { "sequence": "MVGSVWAALGLSLTCISAISLVSPAWFQTTTFSFGVLTYCSWPQGDSWNQSCGTFQSLDDIPDFAWKVSAAMLLGGWLLLAFSAILLLSWALAPKGLCPRRGSGPVPGVQAAAAIATIMGLLVFPVSLASPFAKEACVASSMYHGGQCQLGWGYVTAILNAVLASLLPVITRPHVTEVQRRTIFFSSDTESIILVPETTK", "length": 200, "header": "tr|E1BFU6-1|E1BFU6_BOVIN Isoform 1 of LHFPL tetraspan subfamily member 7 OS=Bos taurus OX=9913 GN=LHFPL7 PE=4 SV=2 CANONICAL=E1BFU6-1" }, "locus": { "chromosome": "17", "start_pos": 65093716, "end_pos": 65089610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008659.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008659.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008659.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008659.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540200", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540200", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RGA0-1", "protein_name": "LHFPL tetraspan subfamily member 7", "gene_name": "LHFPL7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVGSVWAALGLSLTCISALSLISPAWFQTTTFSFGVFTYCSWSQGDRWNQSCGTFRSLDNIPDFAWKVSAAMLLGGWLLLAFNAILLLSWALAPKRLCPRRGSGPMLGVQAAAAIATIVGLLVFPISLASPFAKEACLVSSMYCSGQCQLGWGYVTAILNAVLASLLPMIKWPHVTEVQQRTILFSSDTQSIILMPEMSK", "length": 200 }, "evidence": [ { "id": "E1BFU6", "url": "https://omabrowser.org/oma/group/E1BFU6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UUA0-1", "protein_name": "LHFPL tetraspan subfamily member 7 protein", "gene_name": "Lhfpl7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVGVRAALGLSLTGMSGLSLISPAWFQSLSSSYGIFTYCSWPPGDCWNQSCVTFGSLKDMPSLAWKVSAATLLGGWLLLSISALLLSAWALAPRRLFARTGFGPTPVVQAAAAVSMLVGLLVFPATLASPFAKEICEGSSMYHSGACRLSWGYATAILNMVLTSLLVIRWQVTTVQRAAVPFSSETQRAILVPE", "length": 195 }, "evidence": [ { "id": "E1BFU6", "url": "https://omabrowser.org/oma/group/E1BFU6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ICI0-1", "protein_name": "LHFPL tetraspan subfamily member 7 protein", "gene_name": "LHFPL7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSSVWVALGLSLTCTSAFSLISPAWFQTPTFSFGILTYCSWPQGNSWNQSCVTFSSLEDIPDFAWKVSAVMLLGGWLLLAFNAIFLLSWAVAPKGLCPRRSSVPMPGVQAVAATAMIVGLLIFPIGLASPFIKEVCEASSMYYGGKCRLGWGYMTAILNAVLASLLPIISWPHTTKVQGRTIIFSSATERIIFVPEMNK", "length": 200 }, "evidence": [ { "id": "E1BFU6", "url": "https://omabrowser.org/oma/group/E1BFU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BFU6", "url": "https://www.uniprot.org/uniprotkb/E1BFU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFU6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 200, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFU6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFU6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFX8-1", "uniprot_ac": "E1BFX8", "uniprot_id": "E1BFX8_BOVIN", "mass": { "chemical_mass": 106680.0, "monoisotopic_mass": 106680.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC30", "type": "recommended", "evidence": [ { "id": "E1BFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX8" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 30", "type": "synonym", "evidence": [ { "id": "E1BFX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFX8", "url": "https://www.uniprot.org/uniprotkb/E1BFX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC30", "url": "https://www.uniprot.org/uniprotkb/E1BFX8", "locus": { "chromosome": "3", "start_pos": 103567733, "end_pos": 103704196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004585", "url": "https://www.ensembl.org/id/ENSBTAG00000004585" } ] } } ], "crossref": [ { "id": "E1BFX8", "url": "https://alphafold.ebi.ac.uk/entry/E1BFX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004585", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004585", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34479", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34479", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34479:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34479:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BFX8", "url": "https://www.uniprot.org/uniprotkb/E1BFX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFX8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTASRDLEELAMKHMEEIKDVENYANHVCDLPEEKEAFSHSYEKENKQPRHEFKELQLKPEMQTKEVEMYQEGLSTVALSSPCEQITHLIMERSILLRKLELGNPKPEPQRCLSHNLKKDFPQEKLEQTHQPLQKEHQRHQEPVHQSKKSLNESHNEDPEKDKTPQNCRERDLEDIALQLEVAHEEIRRLTDELRGKEKVQRKLASALEKAQLEIEKLKENLIKLNENDSVDLRKAKEHNQRLDEEILALRNRVRSLDSEKKVLGEEVERLKRRTCEAQENKHLGNHSPGKPVGTEQKVEVLKLLQEFEQLNHFTVGKKTAAANLTSSENTCKDLVPKLPILGIEIQSLKEEKEELCPELGENKQKEIPEKAVKEGTFPREGRKEEDSQQNQEMRGEEQQLTLQPEEVMRLREELSLMNQSLLQSQSSGDTTKDSSFQYPSSGERWKYWQQEEVQQLHQNLRRLQTLCSSAEKELQYERGKNSDLKQHNSLLQEESLKIKIELKQTQEKLSDSSKMCCSLTADWKHCQQKIRELELEVLKQAQSIKSQNNLQEMLAQEKSKVADAEDKILDLQQKLEHAHKVNLTDTCILEKTQLEERIKEAIENEAKIKQQYQEEQQKRKLLDQNLNELQTQVKILQEKESLLEMTSVQQQIKLQQQKAQLEELENEKRKSDEHLKSNQKLSNKLSVLQQEKKALCEENEHLLKQFDLHVRNYNQKHQYYKVKLHIIKDRLVDEVQLRDEKIKQLENEVGALRQQIEKEKAFQDQITTQNDILLLEKRKLLEKVTEQDLLIDSNKWRLFSVQNRVLFLDEENKQLQKNSLRLTQEVYFLEHIIKSIQMHRREETTICDIPESEVLNKIMCLPDSRFSGTGLVESAGSLQATEQRLEETGKPPSPSSPFRVHRILKLDT", "length": 909, "header": "tr|E1BFX8-1|E1BFX8_BOVIN Isoform 1 of Coiled-coil domain containing 30 OS=Bos taurus OX=9913 GN=CCDC30 PE=4 SV=4 CANONICAL=E1BFX8-1" }, "isoforms": [ { "isoform_ac": "E1BFX8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFX8/entry#E1BFX8-1", "sequence": { "sequence": "MTASRDLEELAMKHMEEIKDVENYANHVCDLPEEKEAFSHSYEKENKQPRHEFKELQLKPEMQTKEVEMYQEGLSTVALSSPCEQITHLIMERSILLRKLELGNPKPEPQRCLSHNLKKDFPQEKLEQTHQPLQKEHQRHQEPVHQSKKSLNESHNEDPEKDKTPQNCRERDLEDIALQLEVAHEEIRRLTDELRGKEKVQRKLASALEKAQLEIEKLKENLIKLNENDSVDLRKAKEHNQRLDEEILALRNRVRSLDSEKKVLGEEVERLKRRTCEAQENKHLGNHSPGKPVGTEQKVEVLKLLQEFEQLNHFTVGKKTAAANLTSSENTCKDLVPKLPILGIEIQSLKEEKEELCPELGENKQKEIPEKAVKEGTFPREGRKEEDSQQNQEMRGEEQQLTLQPEEVMRLREELSLMNQSLLQSQSSGDTTKDSSFQYPSSGERWKYWQQEEVQQLHQNLRRLQTLCSSAEKELQYERGKNSDLKQHNSLLQEESLKIKIELKQTQEKLSDSSKMCCSLTADWKHCQQKIRELELEVLKQAQSIKSQNNLQEMLAQEKSKVADAEDKILDLQQKLEHAHKVNLTDTCILEKTQLEERIKEAIENEAKIKQQYQEEQQKRKLLDQNLNELQTQVKILQEKESLLEMTSVQQQIKLQQQKAQLEELENEKRKSDEHLKSNQKLSNKLSVLQQEKKALCEENEHLLKQFDLHVRNYNQKHQYYKVKLHIIKDRLVDEVQLRDEKIKQLENEVGALRQQIEKEKAFQDQITTQNDILLLEKRKLLEKVTEQDLLIDSNKWRLFSVQNRVLFLDEENKQLQKNSLRLTQEVYFLEHIIKSIQMHRREETTICDIPESEVLNKIMCLPDSRFSGTGLVESAGSLQATEQRLEETGKPPSPSSPFRVHRILKLDT", "length": 909, "header": "tr|E1BFX8-1|E1BFX8_BOVIN Isoform 1 of Coiled-coil domain containing 30 OS=Bos taurus OX=9913 GN=CCDC30 PE=4 SV=4 CANONICAL=E1BFX8-1" }, "locus": { "chromosome": "3", "start_pos": 103704077, "end_pos": 103568737, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006021.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006021.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006021.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006021.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 909, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFX8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 583, "end_pos": 585 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFX9-1", "uniprot_ac": "E1BFX9", "uniprot_id": "E1BFX9_BOVIN", "mass": { "chemical_mass": 63735.0, "monoisotopic_mass": 63735.0 }, "refseq": { "ac": "XP_024831579", "name": "ovochymase-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831579" }, "gene_names": [ { "name": "OVCH2", "type": "recommended", "evidence": [ { "id": "E1BFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" } ] }, { "name": "OVCH2", "type": "synonym", "evidence": [ { "id": "XP_024831579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831579" } ] } ], "protein_names": [ { "name": "Ovochymase 2", "type": "synonym", "evidence": [ { "id": "E1BFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX9/entry#names_and_taxonomy" } ] }, { "name": "ovochymase-2", "type": "synonym", "evidence": [ { "id": "XP_024831579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831579" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFX9", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OVCH2", "url": "https://www.uniprot.org/uniprotkb/E1BFX9", "locus": { "chromosome": "15", "start_pos": 45024945, "end_pos": 44973505, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037921", "url": "https://www.ensembl.org/id/ENSBTAG00000037921" } ] } } ], "crossref": [ { "id": "E1BFX9", "url": "https://alphafold.ebi.ac.uk/entry/E1BFX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037921", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037921", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782899", "url": "https://www.ncbi.nlm.nih.gov/gene/782899", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782899", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782899", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024831579", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFX9", "url": "https://www.uniprot.org/uniprotkb/E1BFX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFX9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHISKKKLILLFGIIFLEQSKSATLSLPKVSTCGQSPVKSQPLNYLNIFSRIVGGRQVAKGSYPWQVSLKQRQKHVCGGTIISPQWVITAAHCVANRNTVSTFNVTAGEYDLRYVEPGEQTLTIETIIIHPHFSTKKPMDYDIALLKMAGAFRFDQFVGPMCLPEPGERFKPGFICTTAGWGRLSENGISPQVLQEVNLPILTQDECITALLTLEKPISGRTFLCTGFPDGGRDACQGDSGGSLMCRNKKGTWTMAGVTSWGLGCGRGWKNNLQKDDQGSPGIFTDLTKVLSWIHKHIRIGKQRKSSRATCSEQDRVVRALEGDLHFPESPFLYYESKQQCAWTLLVPEEMHVLLSFSHFDAESCDHNYLSIYSLEDTLIAKFCGERLASSVLVGSNAIRLSFISDNTDNAVGFNLTYKAVKPNYLPDSGCDSLTILFEEGLIQSPHYPEDYSNMASCNWVFQAPKHYLVKLSFQDLKIEENGDCTSDYVSVHRDVERKKEIARLCGFAVPTPVVSITRVMSISFQSNENANFRGFQATVSFVHETDFNISGLENESVFLETWNVPPERIQ", "length": 571, "header": "tr|E1BFX9-1|E1BFX9_BOVIN Isoform 1 of Ovochymase 2 OS=Bos taurus OX=9913 GN=OVCH2 PE=4 SV=4 CANONICAL=E1BFX9-1" }, "isoforms": [ { "isoform_ac": "E1BFX9-1", "url": "https://www.uniprot.org/uniprotkb/E1BFX9/entry#E1BFX9-1", "sequence": { "sequence": "MHISKKKLILLFGIIFLEQSKSATLSLPKVSTCGQSPVKSQPLNYLNIFSRIVGGRQVAKGSYPWQVSLKQRQKHVCGGTIISPQWVITAAHCVANRNTVSTFNVTAGEYDLRYVEPGEQTLTIETIIIHPHFSTKKPMDYDIALLKMAGAFRFDQFVGPMCLPEPGERFKPGFICTTAGWGRLSENGISPQVLQEVNLPILTQDECITALLTLEKPISGRTFLCTGFPDGGRDACQGDSGGSLMCRNKKGTWTMAGVTSWGLGCGRGWKNNLQKDDQGSPGIFTDLTKVLSWIHKHIRIGKQRKSSRATCSEQDRVVRALEGDLHFPESPFLYYESKQQCAWTLLVPEEMHVLLSFSHFDAESCDHNYLSIYSLEDTLIAKFCGERLASSVLVGSNAIRLSFISDNTDNAVGFNLTYKAVKPNYLPDSGCDSLTILFEEGLIQSPHYPEDYSNMASCNWVFQAPKHYLVKLSFQDLKIEENGDCTSDYVSVHRDVERKKEIARLCGFAVPTPVVSITRVMSISFQSNENANFRGFQATVSFVHETDFNISGLENESVFLETWNVPPERIQ", "length": 571, "header": "tr|E1BFX9-1|E1BFX9_BOVIN Isoform 1 of Ovochymase 2 OS=Bos taurus OX=9913 GN=OVCH2 PE=4 SV=4 CANONICAL=E1BFX9-1" }, "locus": { "chromosome": "15", "start_pos": 45024937, "end_pos": 45001013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052858.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052858.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051470.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051470.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782899", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782899", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BFX9", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BFX9", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "E1BFX9", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFX9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 571, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFX9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFX9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 311, "end_pos": 421, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFX9" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 299, "start_aa": "Ile", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 549, "end_pos": 551 }, { "start_pos": 555, "end_pos": 557 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFY1-1", "uniprot_ac": "E1BFY1", "uniprot_id": "E1BFY1_BOVIN", "mass": { "chemical_mass": 76723.0, "monoisotopic_mass": 76723.0 }, "refseq": { "ac": "XP_005215304", "name": "zinc finger protein 7 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215304" }, "gene_names": [ { "name": "ZNF7", "type": "recommended", "evidence": [ { "id": "E1BFY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ] }, { "name": "ZNF7", "type": "synonym", "evidence": [ { "id": "XP_005215304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215304" } ] } ], "protein_names": [ { "name": "Zinc finger protein 7", "type": "recommended", "evidence": [ { "id": "E1BFY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 7 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005215304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215304" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF7", "url": "https://www.uniprot.org/uniprotkb/E1BFY1", "locus": { "chromosome": "14", "start_pos": 340354, "end_pos": 331399, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018456", "url": "https://www.ensembl.org/id/ENSBTAG00000018456" } ] } } ], "crossref": [ { "id": "E1BFY1", "url": "https://alphafold.ebi.ac.uk/entry/E1BFY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785799", "url": "https://www.ncbi.nlm.nih.gov/gene/785799", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFY1", "url": "https://www.orthodb.org/?gene=E1BFY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215304", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215304", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAVTFGDVAVHFSREEWQCLDPGQRALYKEVMLENHSSVAGLAGFLVFKPELISRLEQGQDPWVLDLQGAEGREEARTTRTDSTVGTDGEQDMDSFKSESGGVMVKTLPQNFPQSPGFGNTSDPEVCSQRQPTSLFHKNFLNMGTMGPRKAFTEDEFQGHGEWGSSGRLGCQPDQSQWSFGRCDVCGRSLRSPSDAALHQEVNTQQKPNRCQECQKQLSDCFQGRPLSTFPGEKPYECRECGKVFRLCSQLTQHQRIHTGEKPFKCTDCGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIHHQRVHTGERPYGCRECGKAFSQQSQLARHQRTHTGERPYPCRECGKAFSQSSTLAQHQRMHAAEKLELPRTPESPSLGARQRMHVPEKPFKCDECGKAFRWVSRLSQHQLTHTGEKPYKCNKCSKAFGCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYECSDCGKAFSQSSSLIYHQRIHKGEKPYECLECGKAFSMSTQLTIHQRVHTGERPYKCSECGKAFSQNSTLFQHQIIHAGVKPYGCSECGKAFSRSSYLIEHQRIHTRAQWYREYGSTLEASTHTSRRRVNTVKKLHKCNECEKIFRWRSHLIIHQRIHTGEKPYKCNECDKAFNRSSRLTQHQKIHMG", "length": 673, "header": "tr|E1BFY1-1|E1BFY1_BOVIN Isoform 1 of Zinc finger protein 7 OS=Bos taurus OX=9913 GN=ZNF7 PE=3 SV=5 CANONICAL=E1BFY1-1" }, "isoforms": [ { "isoform_ac": "E1BFY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1/entry#E1BFY1-1", "sequence": { "sequence": "MEAVTFGDVAVHFSREEWQCLDPGQRALYKEVMLENHSSVAGLAGFLVFKPELISRLEQGQDPWVLDLQGAEGREEARTTRTDSTVGTDGEQDMDSFKSESGGVMVKTLPQNFPQSPGFGNTSDPEVCSQRQPTSLFHKNFLNMGTMGPRKAFTEDEFQGHGEWGSSGRLGCQPDQSQWSFGRCDVCGRSLRSPSDAALHQEVNTQQKPNRCQECQKQLSDCFQGRPLSTFPGEKPYECRECGKVFRLCSQLTQHQRIHTGEKPFKCTDCGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIHHQRVHTGERPYGCRECGKAFSQQSQLARHQRTHTGERPYPCRECGKAFSQSSTLAQHQRMHAAEKLELPRTPESPSLGARQRMHVPEKPFKCDECGKAFRWVSRLSQHQLTHTGEKPYKCNKCSKAFGCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYECSDCGKAFSQSSSLIYHQRIHKGEKPYECLECGKAFSMSTQLTIHQRVHTGERPYKCSECGKAFSQNSTLFQHQIIHAGVKPYGCSECGKAFSRSSYLIEHQRIHTRAQWYREYGSTLEASTHTSRRRVNTVKKLHKCNECEKIFRWRSHLIIHQRIHTGEKPYKCNECDKAFNRSSRLTQHQKIHMG", "length": 673, "header": "tr|E1BFY1-1|E1BFY1_BOVIN Isoform 1 of Zinc finger protein 7 OS=Bos taurus OX=9913 GN=ZNF7 PE=3 SV=5 CANONICAL=E1BFY1-1" }, "locus": { "chromosome": "14", "start_pos": 339108, "end_pos": 333654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037366.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037366.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037199.7", "url": "https://www.ensembl.org/id/ENSBTAP00000037199.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BFY1", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFY1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 673, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFY1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFY1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 209, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFY1" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 76, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 552, "end_pos": 554 }, { "start_pos": 659, "end_pos": 661 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BFZ1-1", "uniprot_ac": "E1BFZ1", "uniprot_id": "E1BFZ1_BOVIN", "mass": { "chemical_mass": 21184.0, "monoisotopic_mass": 21184.0 }, "refseq": {}, "gene_names": [ { "name": "PINLYP", "type": "recommended", "evidence": [ { "id": "E1BFZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" } ] } ], "protein_names": [ { "name": "Phospholipase A2 inhibitor and LY6/PLAUR domain containing", "type": "synonym", "evidence": [ { "id": "E1BFZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BFZ1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PINLYP", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1", "locus": { "chromosome": "18", "start_pos": 51788190, "end_pos": 51783851, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001260", "url": "https://www.ensembl.org/id/ENSBTAG00000001260" } ] } } ], "crossref": [ { "id": "E1BFZ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BFZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001260", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001260", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23571", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23571", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050918", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050918", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616860", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR20914", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20914", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20914:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20914:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02988", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02988", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BFZ1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPSMKLETFLLATTLLCTLLGLGYPLSCEVCVGDGPNCRGKLQTCAPDEDSCIVVVTETNRKASLAVTSYKGCSKSSNCESGLFGFTVNHENYMGSKRRCCQKDGCNQDPLPAFVRNHTENGLRCPSCITAFTETCTATAEALCVGEETHCVAMSGLMRPGDKFAVQGCGTKTACHSKPGTLVPSGARLFTIKKTSCL", "length": 199, "header": "tr|E1BFZ1-1|E1BFZ1_BOVIN Isoform 1 of Phospholipase A2 inhibitor and LY6/PLAUR domain containing OS=Bos taurus OX=9913 GN=PINLYP PE=3 SV=5 CANONICAL=E1BFZ1-1" }, "isoforms": [ { "isoform_ac": "E1BFZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1/entry#E1BFZ1-1", "sequence": { "sequence": "MKPSMKLETFLLATTLLCTLLGLGYPLSCEVCVGDGPNCRGKLQTCAPDEDSCIVVVTETNRKASLAVTSYKGCSKSSNCESGLFGFTVNHENYMGSKRRCCQKDGCNQDPLPAFVRNHTENGLRCPSCITAFTETCTATAEALCVGEETHCVAMSGLMRPGDKFAVQGCGTKTACHSKPGTLVPSGARLFTIKKTSCL", "length": 199, "header": "tr|E1BFZ1-1|E1BFZ1_BOVIN Isoform 1 of Phospholipase A2 inhibitor and LY6/PLAUR domain containing OS=Bos taurus OX=9913 GN=PINLYP PE=3 SV=5 CANONICAL=E1BFZ1-1" }, "locus": { "chromosome": "18", "start_pos": 51788051, "end_pos": 51784174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031940.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031940.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031886.7", "url": "https://www.ensembl.org/id/ENSBTAP00000031886.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616860", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616860", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BFZ1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phospholipase inhibitor activity", "id": "GO:0004859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004859", "evidence": [ { "database": "UniProtKB", "id": "E1BFZ1", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BFZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 199, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BFZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BFZ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BFZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" }, { "id": "PF02988", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02988" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phospholipase A2 inhibitor N-terminal", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 108, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFZ1" }, { "id": "PF00021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UPAR/Ly6", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 182, "start_aa": "Asn", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG03-1", "uniprot_ac": "E1BG03", "uniprot_id": "E1BG03_BOVIN", "mass": { "chemical_mass": 35115.0, "monoisotopic_mass": 35115.0 }, "refseq": { "ac": "NP_001376755", "name": "olfactory receptor family 51 subfamily S member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376755" }, "gene_names": [ { "name": "OR51S1", "type": "recommended", "evidence": [ { "id": "E1BG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ] }, { "name": "OR51S1", "type": "synonym", "evidence": [ { "id": "NP_001376755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376755" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 51 subfamily S member 1", "type": "synonym", "evidence": [ { "id": "E1BG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG03/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily S member 1", "type": "synonym", "evidence": [ { "id": "NP_001376755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376755" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376755" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51S1", "url": "https://www.uniprot.org/uniprotkb/E1BG03", "locus": { "chromosome": "15", "start_pos": 48823981, "end_pos": 48824949, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065473", "url": "https://www.ensembl.org/id/ENSBTAG00000065473" } ] } } ], "crossref": [ { "id": "E1BG03", "url": "https://alphafold.ebi.ac.uk/entry/E1BG03", "database": "AlphaFoldDB", "categories": [] }, { "id": "509175", "url": "https://www.ncbi.nlm.nih.gov/gene/509175", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509175", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509175", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XPMILLA", "url": "https://omabrowser.org/oma/group/XPMILLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BG03", "url": "https://www.orthodb.org/?gene=E1BG03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG03-1", "url": "https://www.uniprot.org/uniprotkb/E1BG03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTFLTHSTPNASTSMAPTFLLVGLPGLSAVPSWWAVPLITVYLLSALGNGAILWIIALEPTLHRPMYFFLFLLSMSDVGLSTALMPTLLGLAFANTHAVSASACLLQMFFVHVFSVVESSVLLAMALDRALAICRPLHYPTLLTNGVISKICVAIAFRCLGLHLPLPFLLAHMPYCRPQVLTHSYCLHPDIARLACPGGGGAVYSLFVVLSAMGLDPLLILFSYGLIGRVLQGLGSCEDRWKAGQTCAAHLSAVLLFYVPMVLLALIDRLRMPIPQPACTLLSYVHFLLPPLINPILYSVKMKEIRERIHKRLQPRKVGCA", "length": 322, "header": "tr|E1BG03-1|E1BG03_BOVIN Isoform 1 of Olfactory receptor family 51 subfamily S member 1 OS=Bos taurus OX=9913 GN=OR51S1 PE=3 SV=3 CANONICAL=E1BG03-1" }, "isoforms": [ { "isoform_ac": "E1BG03-1", "url": "https://www.uniprot.org/uniprotkb/E1BG03/entry#E1BG03-1", "sequence": { "sequence": "MSTFLTHSTPNASTSMAPTFLLVGLPGLSAVPSWWAVPLITVYLLSALGNGAILWIIALEPTLHRPMYFFLFLLSMSDVGLSTALMPTLLGLAFANTHAVSASACLLQMFFVHVFSVVESSVLLAMALDRALAICRPLHYPTLLTNGVISKICVAIAFRCLGLHLPLPFLLAHMPYCRPQVLTHSYCLHPDIARLACPGGGGAVYSLFVVLSAMGLDPLLILFSYGLIGRVLQGLGSCEDRWKAGQTCAAHLSAVLLFYVPMVLLALIDRLRMPIPQPACTLLSYVHFLLPPLINPILYSVKMKEIRERIHKRLQPRKVGCA", "length": 322, "header": "tr|E1BG03-1|E1BG03_BOVIN Isoform 1 of Olfactory receptor family 51 subfamily S member 1 OS=Bos taurus OX=9913 GN=OR51S1 PE=3 SV=3 CANONICAL=E1BG03-1" }, "locus": { "chromosome": "15", "start_pos": 48824949, "end_pos": 48823984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052106.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052106.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049142.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049142.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509175", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509175", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "E1BG03", "url": "https://www.uniprot.org/uniprotkb/E1BG03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG03-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 322, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG03-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG03" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG03" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 299, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG12-1", "uniprot_ac": "E1BG12", "uniprot_id": "E1BG12_BOVIN", "mass": { "chemical_mass": 30785.0, "monoisotopic_mass": 30785.0 }, "refseq": { "ac": "XP_059749044", "name": "peptidase inhibitor R3HDML isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749044" }, "gene_names": [ { "name": "R3HDML", "type": "recommended", "evidence": [ { "id": "E1BG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG12" } ] }, { "name": "R3HDML", "type": "synonym", "evidence": [ { "id": "XP_059749044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749044" } ] } ], "protein_names": [ { "name": "R3H domain containing like", "type": "synonym", "evidence": [ { "id": "E1BG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG12/entry#names_and_taxonomy" } ] }, { "name": "peptidase inhibitor R3HDML isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059749044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749044" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG12", "url": "https://www.uniprot.org/uniprotkb/E1BG12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "R3HDML", "url": "https://www.uniprot.org/uniprotkb/E1BG12", "locus": { "chromosome": "13", "start_pos": 72781373, "end_pos": 72770399, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013220", "url": "https://www.ensembl.org/id/ENSBTAG00000013220" } ] } } ], "crossref": [ { "id": "E1BG12", "url": "https://alphafold.ebi.ac.uk/entry/E1BG12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013220", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013220", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18815", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18815", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533734", "url": "https://www.ncbi.nlm.nih.gov/gene/533734", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BG12", "url": "https://www.orthodb.org/?gene=E1BG12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059749044", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749044", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BG12", "url": "https://www.uniprot.org/uniprotkb/E1BG12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG12-1", "url": "https://www.uniprot.org/uniprotkb/E1BG12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQGRQPALTARGQTWDPFQPAMPPLPGTVGLAGLLFWAGQTMNALMPNTTLALTQTKGTAVRPLSGLGVPRYRRKRHISARDMSALLDYHNHIRASVHPPAANMEYMVWDERLARSAEAWASQCIWAHGPSQLMRYVGQNLSVHSGRYRSVVDLVKSWSEEKRHYLFPAPKDCTPRCPWRCSGPVCSHYTQMVWASSNRLGCAIHTCGSIRVWGSTWRQAVYLVCNYAIKGNWIGEAPYKTGRPCSACPPIYQGSCSSNMCFSRRKSNKLLWF", "length": 274, "header": "tr|E1BG12-1|E1BG12_BOVIN Isoform 1 of R3H domain containing like OS=Bos taurus OX=9913 GN=R3HDML PE=3 SV=4 CANONICAL=E1BG12-1" }, "isoforms": [ { "isoform_ac": "E1BG12-1", "url": "https://www.uniprot.org/uniprotkb/E1BG12/entry#E1BG12-1", "sequence": { "sequence": "MPQGRQPALTARGQTWDPFQPAMPPLPGTVGLAGLLFWAGQTMNALMPNTTLALTQTKGTAVRPLSGLGVPRYRRKRHISARDMSALLDYHNHIRASVHPPAANMEYMVWDERLARSAEAWASQCIWAHGPSQLMRYVGQNLSVHSGRYRSVVDLVKSWSEEKRHYLFPAPKDCTPRCPWRCSGPVCSHYTQMVWASSNRLGCAIHTCGSIRVWGSTWRQAVYLVCNYAIKGNWIGEAPYKTGRPCSACPPIYQGSCSSNMCFSRRKSNKLLWF", "length": 274, "header": "tr|E1BG12-1|E1BG12_BOVIN Isoform 1 of R3H domain containing like OS=Bos taurus OX=9913 GN=R3HDML PE=3 SV=4 CANONICAL=E1BG12-1" }, "locus": { "chromosome": "13", "start_pos": 72780369, "end_pos": 72770598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017591.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017591.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017591.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017591.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BG12", "url": "https://www.uniprot.org/uniprotkb/E1BG12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "E1BG12", "url": "https://www.uniprot.org/uniprotkb/E1BG12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 274, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG12" }, { "id": "SM00198", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00198" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCP", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 236, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG14-1", "uniprot_ac": "E1BG14", "uniprot_id": "E1BG14_BOVIN", "mass": { "chemical_mass": 31626.0, "monoisotopic_mass": 31626.0 }, "refseq": { "ac": "XP_002698253", "name": "histone deacetylase complex subunit SAP25 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698253" }, "gene_names": [ { "name": "SAP25", "type": "recommended", "evidence": [ { "id": "E1BG14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG14" } ] }, { "name": "SAP25", "type": "synonym", "evidence": [ { "id": "XP_002698253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698253" } ] } ], "protein_names": [ { "name": "Sin3A associated protein 25", "type": "synonym", "evidence": [ { "id": "E1BG14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG14/entry#names_and_taxonomy" } ] }, { "name": "histone deacetylase complex subunit SAP25 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_002698253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698253" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG14", "url": "https://www.uniprot.org/uniprotkb/E1BG14" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAP25", "url": "https://www.uniprot.org/uniprotkb/E1BG14", "locus": { "chromosome": "25", "start_pos": 35984508, "end_pos": 35982475, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039601", "url": "https://www.ensembl.org/id/ENSBTAG00000039601" } ] } } ], "crossref": [ { "id": "E1BG14", "url": "https://alphafold.ebi.ac.uk/entry/E1BG14", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039601", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039601", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100296776", "url": "https://www.ncbi.nlm.nih.gov/gene/100296776", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296776", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296776", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR39231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39231:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39231:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15476", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15476", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698253", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BG14", "url": "https://www.uniprot.org/uniprotkb/E1BG14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG14-1", "url": "https://www.uniprot.org/uniprotkb/E1BG14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPWTPRQWGAGEEQAPRERRPSVGSGLSQAWDSREKALGEPGTAAQGSPQPWPRRLSWTRKEQLRPRLPPGLAAKHSLGTPVPFSPQRTWGVAPSKMALLAPWDPNYEATAGRRLVWGPSCASGVSFSGRTLYHPSFWPLYQAASCRGLRPSLAGHRGEEQAPRTAGFPVMCSEDVFFLDPLLPHGQRVPLYLSEVPQQVMGSLKLLLPRPIMSPWLLPIPSSGCSTTWLSGPELIALTGLLQMSQGEPRPSSSGAPGLPSGSPAPASDHPAASGGPGCSHCGEPSLPGTPDAQGP", "length": 297, "header": "tr|E1BG14-1|E1BG14_BOVIN Isoform 1 of Sin3A associated protein 25 OS=Bos taurus OX=9913 GN=SAP25 PE=4 SV=4 CANONICAL=E1BG14-1" }, "isoforms": [ { "isoform_ac": "E1BG14-1", "url": "https://www.uniprot.org/uniprotkb/E1BG14/entry#E1BG14-1", "sequence": { "sequence": "MLPWTPRQWGAGEEQAPRERRPSVGSGLSQAWDSREKALGEPGTAAQGSPQPWPRRLSWTRKEQLRPRLPPGLAAKHSLGTPVPFSPQRTWGVAPSKMALLAPWDPNYEATAGRRLVWGPSCASGVSFSGRTLYHPSFWPLYQAASCRGLRPSLAGHRGEEQAPRTAGFPVMCSEDVFFLDPLLPHGQRVPLYLSEVPQQVMGSLKLLLPRPIMSPWLLPIPSSGCSTTWLSGPELIALTGLLQMSQGEPRPSSSGAPGLPSGSPAPASDHPAASGGPGCSHCGEPSLPGTPDAQGP", "length": 297, "header": "tr|E1BG14-1|E1BG14_BOVIN Isoform 1 of Sin3A associated protein 25 OS=Bos taurus OX=9913 GN=SAP25 PE=4 SV=4 CANONICAL=E1BG14-1" }, "locus": { "chromosome": "25", "start_pos": 35984147, "end_pos": 35982674, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052893.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052893.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051441.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051441.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296776", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296776", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BG14", "url": "https://www.uniprot.org/uniprotkb/E1BG14" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BG14", "url": "https://www.uniprot.org/uniprotkb/E1BG14" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BG14", "url": "https://www.uniprot.org/uniprotkb/E1BG14" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG14-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG14-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG14" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG21-1", "uniprot_ac": "E1BG21", "uniprot_id": "E1BG21_BOVIN", "mass": { "chemical_mass": 72962.0, "monoisotopic_mass": 72962.0 }, "refseq": { "ac": "NP_001179396", "name": "E3 ubiquitin-protein ligase ZSWIM2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179396" }, "gene_names": [ { "name": "ZSWIM2", "type": "recommended", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ] }, { "name": "ZSWIM2", "type": "synonym", "evidence": [ { "id": "NP_001179396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179396" } ] } ], "protein_names": [ { "name": "RING-type E3 ubiquitin transferase", "type": "recommended", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase ZSWIM2", "type": "synonym", "evidence": [ { "id": "NP_001179396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179396" } ] }, { "name": "MEKK1-related protein X", "type": "synonym", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#names_and_taxonomy" } ] }, { "name": "ZZ-type zinc finger-containing protein 2", "type": "synonym", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger SWIM domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.", "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21#function" }, { "database": "UniProtKB", "id": "ARBA00056008", "url": "https://www.uniprot.org/uniprotkb/ARBA00056008#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSWIM2", "url": "https://www.uniprot.org/uniprotkb/E1BG21", "locus": { "chromosome": "2", "start_pos": 9512821, "end_pos": 9491541, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007580", "url": "https://www.ensembl.org/id/ENSBTAG00000007580" } ] } } ], "crossref": [ { "id": "E1BG21", "url": "https://alphafold.ebi.ac.uk/entry/E1BG21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007580", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007580", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16486", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16486", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16494", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16494", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517320", "url": "https://www.ncbi.nlm.nih.gov/gene/517320", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517320", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517320", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YNPLTWK", "url": "https://omabrowser.org/oma/group/YNPLTWK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BG21", "url": "https://www.orthodb.org/?gene=E1BG21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21540", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21540", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21540:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21540:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179396", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG21-1", "url": "https://www.uniprot.org/uniprotkb/E1BG21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRGGCKASERRKHLIDRLSWQQDQALSSSIYLLREMGPTAFLLREEEPENRDFRVSLGNPHVCNCSTFLKGGELCKHICWVLLKKFRLPRNHESALQLGLVEREINGLLQGIHRVQTPQREMNNENAQTEEDGYIKQKEIGSDDICSICQEVLLEKKLPVTFCRFGCGNSVHIKCMKILANYQDVPLNSSMLKCPLCRKDFGPLNLILEEFKNSNKLVTAAEKERLDKHLGIPCNNCQQFPLEGKCYKCTKCIEYHLCQDCFDSCCHLSHSFMFREKRNQKWRSLGKRSDKTVKYVDIKDEIEEKMPHFQEKQDQIYTPKHVVKSLPLFLITKNSKLLAPGYQCRLCLKAFRRGQHTRQLPCTHKFHRKCIDSWLLYKCNSCPIDGQVIYNPLIWNDRAVNGHVHHSVSNTDVTHLPKQEESELFIPGTGLVLKQNKPGILPILPQRNSEKLNTPQSPNDTYQNITIDNLYSIKLDDSNSRKSIYECKSNQHFPSYLQDLPTGSFGKTSSQTLFPSIDHKNIIHLTERKNPCINKKHHTNQSQKMNKSCKGTNHKSKKILGNKVREDNTRSNTLLPDLSLIVSWGTTKLSLSKRYNCMGKIRPKCSHLSRRPVSHPLNTKSPELSLILEGVHL", "length": 634, "header": "tr|E1BG21-1|E1BG21_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=ZSWIM2 PE=4 SV=1 CANONICAL=E1BG21-1" }, "isoforms": [ { "isoform_ac": "E1BG21-1", "url": "https://www.uniprot.org/uniprotkb/E1BG21/entry#E1BG21-1", "sequence": { "sequence": "MLRGGCKASERRKHLIDRLSWQQDQALSSSIYLLREMGPTAFLLREEEPENRDFRVSLGNPHVCNCSTFLKGGELCKHICWVLLKKFRLPRNHESALQLGLVEREINGLLQGIHRVQTPQREMNNENAQTEEDGYIKQKEIGSDDICSICQEVLLEKKLPVTFCRFGCGNSVHIKCMKILANYQDVPLNSSMLKCPLCRKDFGPLNLILEEFKNSNKLVTAAEKERLDKHLGIPCNNCQQFPLEGKCYKCTKCIEYHLCQDCFDSCCHLSHSFMFREKRNQKWRSLGKRSDKTVKYVDIKDEIEEKMPHFQEKQDQIYTPKHVVKSLPLFLITKNSKLLAPGYQCRLCLKAFRRGQHTRQLPCTHKFHRKCIDSWLLYKCNSCPIDGQVIYNPLIWNDRAVNGHVHHSVSNTDVTHLPKQEESELFIPGTGLVLKQNKPGILPILPQRNSEKLNTPQSPNDTYQNITIDNLYSIKLDDSNSRKSIYECKSNQHFPSYLQDLPTGSFGKTSSQTLFPSIDHKNIIHLTERKNPCINKKHHTNQSQKMNKSCKGTNHKSKKILGNKVREDNTRSNTLLPDLSLIVSWGTTKLSLSKRYNCMGKIRPKCSHLSRRPVSHPLNTKSPELSLILEGVHL", "length": 634, "header": "tr|E1BG21-1|E1BG21_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=ZSWIM2 PE=4 SV=1 CANONICAL=E1BG21-1" }, "locus": { "chromosome": "2", "start_pos": 9512727, "end_pos": 9491627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009973.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009973.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000009973.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:517320", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517320", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RYJ1-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "ZSWIM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRGGYKASERRRHLSDRLSRRQDQALSSSIYLLREMGPTAFLLREEEPENKDFRVSLGNPHVCNCSVFLKGGELCKHICWVLLKKFKLPRNHESALQLGLVEGEISNLLRGIPQVQTPQQGTNDENAQIEEDGYIKQKEIGSDDICSICQEVLLEKKLPVTFCRLGCGNNVHIKCMKILANFQDMTSNNSMLKCPLCRKEFAPLKLISEEFKNSSRLVTAAEKQRLDKHLGIPCNNCQQFPIEGKCYKCTECIEYHLCQECFDSSCHLSHSFIFREKRNQRWRSLEKRSDETVKYVDIKTEIEGKMPHFQEKQGQVYTPKHVVKSLPLLLITKNSKLLAPGYQCRLCLKAFHLGQHTRLLPCAHKFHRKCIDSWLFHQCNSCPIDGQVIYNPLIWKDTAVNGHAHQSVSNTDIPHLSKQEELFIPGTGLVLKQNSLGILPSIPQCNSEKLNTTQSPTDTYQNITIDDLYSIKLDDSNSRKSTYDYKVSQHFPRYLHDLPTGSYGKMSSQTFFPSVHHKRLTCLTGMENPCISKTHHTGQSQKMSKDCKCIVHNSKKILGTEIKKDNARSSTLLPDDLNLTVNGGKTNLSLSKRYNHCIGKIRPKCSHLSRRPISYPLKTKSTELSLILEGVQL", "length": 634 }, "evidence": [ { "id": "E1BG21", "url": "https://omabrowser.org/oma/group/E1BG21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FQ1-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Zswim2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRGGCKASEKRRHLSESLSWQQDQALSSSIYLLRQIGPTGFLLREEEPENGDFRVLLGNPHECSCPTFLKRGELCKHICWVLLKKFKLPRNHESAFQLGLTEGEINDLLRGIHQVQTPQLRASEETARVEEDGYLKQKDISAGDICPICQEVLLEKRLPVTFCRFGCGNNVHIKCMRILANYQDTVSDTSMLKCPLCREEFAPLKVILEEFKNSNKLMTISEKERLDKHLGIPCNNCTQLPIEGKCYKCTECVEYHLCQECFDSCYHPSHAFVFREKRNQRWRSVEKRSDVVKYLDTKNEGEANMPYFKEKPGSFCLSSLSQFYTPKHVVKSLPLLLITKNSKLLAPGYQCRLCLKSFCLGQYTRLLPCTHKFHRKCIDNWLFHKCNSCPIDRQVIYNPLIWKGAAMDGQAHQLASNKDIAHLSKQQEPKLFIPGTGLVLKQNRTGILPRIPQYNSKVLTTFPNPSDNYQNITMDDLCSVKIDNSDSRKLVFGYKISKPFPTYLQDPAAGPTPSQTFLPSLPHKNVICLTGRESPHIYEKDHTGRSQKTSRGYEHINYNTRKALGTRLRQHKRSSTLSTEDLNLTINWGTTKLSLSKKPNNSTGKVRQKCGRPPRRPAYHPLQTQSAALSLIMEGIQL", "length": 639 }, "evidence": [ { "id": "E1BG21", "url": "https://omabrowser.org/oma/group/E1BG21/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NEG5-1", "protein_name": "E3 ubiquitin-protein ligase ZSWIM2", "gene_name": "ZSWIM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRRGYKASERRRHLSERLSWHQDQALSSSIYLLREMGPTGFLLREEEPEYMDFRVFLGNPHVCNCSTFPKGGELCKHICWVLLKKFKLPRNHESALQLGLGEREISDLLRGIHRVQTPQPGTNDENEHVEEDGYIKQKEIDSEDICSICQELLLEKKLPVTFCRFGCGNSIHIKCMKILANYQSTSNTSMLKCPLCRKEFAPLKLILEEFKNSSKLVAAAEKERLDKHLGIPCNNCKQFPIEGKCYKCTECIEYHLCQECFDSCCHLSHTFTFREKRNQKWRSLEKRADEVVKYIDTKNEIEEKMSHFQEKQGQVYTPKHIVRSLPLQLITKNSKLLAPGYQCLLCLKAFHLGQHTRLLPCTHKFHRKCIDNWLFHKCNSCPIDGQVIYNPLTWKNSAVNGQAHQSVSNRDIIHLSKQKEPDLFIPGTGLVLKQNRLGILPSIPQCNFDELNTPQSPKDAYENTTIDNLCSIKLDNSNSKKLTYDYKISQHFPRYLQDLPTVSFGKIPSQTLLPPIVHKNIVCPTAMESPCISGKFHTSLSRMTKGCKCNNHNLKKTPATKIREDNKRSTLLPEDFNLIVNWSTAKLSLSKRYSNCMGEITRKCSHLSRQPVSHSVNTKSTELSLIIEGVQL", "length": 633 }, "evidence": [ { "id": "E1BG21", "url": "https://omabrowser.org/oma/group/E1BG21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9X6-1", "protein_name": "E3 ubiquitin-protein ligase Zswim2", "gene_name": "Zswim2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRGGCKASEKRRHLSESLSWQQDQALSSSIYLLRQIGPTGFLLKEEEPEKGDFRVLLGNPHECSCPTFLKRGELCKHICWVLLKKFKLPRNHESAFQLGLTEGEINDLLRGIHQVQAPQLRASDETAQVEEDGYLKQKDINAGDICPICQEVLLEKKLPVTFCRFGCGNNVHIKCMRILANYQDTGSDSSVLRCPLCREEFAPLKVILEEFKNSNKLITISEKERLDKHLGIPCNNCNQLPIEGRCYKCTECVEYHLCQECFDSCCHSSHAFASREKRNQRWRSVEKRSEVMKYLNTENEGEAKPGCFQEKQGQFYTPKHVVKSLPLLMITKKSKLLAPGYQCRLCLKSFSFGQYTRLLPCTHKFHRKCIDNWLLHKCNSCPIDRQVIYNPLIWKGIATDGQAHQLASSKDIACLSKQQEPKLFIPGTGLVLKGKRMGVLPSIPQYNSKVLTTLQNPSDNYQNITMDDLCSVKLDNSNSRKLVFGYKISKQFPTYLKNPTTGQTPSQTFLPSLPHKNIICLTGRESPHIYEKDHIGQSQKTSRGYEHINYNTRKSLGSRLRQHKRSSALSSEDLNLTINLGTTKLSLSKRQNNSMGKVRQKLGHPPRRPAYPPLQTQNAALSLIMQGIQL", "length": 631 }, "evidence": [ { "id": "E1BG21", "url": "https://omabrowser.org/oma/group/E1BG21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "E1BG21", "url": "https://www.uniprot.org/uniprotkb/E1BG21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" }, { "start_pos": 547, "end_pos": 549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 634, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG21" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 199, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21" }, { "id": "PS50966", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50966" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIM-type", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 87, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BG21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG21" }, { "id": "PS50135", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZZ-type", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 281, "start_aa": "His", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 541, "end_pos": 543 }, { "start_pos": 547, "end_pos": 549 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG64-1", "uniprot_ac": "E1BG64", "uniprot_id": "E1BG64_BOVIN", "mass": { "chemical_mass": 42184.0, "monoisotopic_mass": 42184.0 }, "refseq": { "ac": "NP_001179979", "name": "fasciculation and elongation protein zeta-2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179979" }, "gene_names": [ { "name": "FEZ2", "type": "recommended", "evidence": [ { "id": "E1BG64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG64" } ] }, { "name": "FEZ2", "type": "synonym", "evidence": [ { "id": "NP_001179979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179979" } ] } ], "protein_names": [ { "name": "Fasciculation and elongation protein zeta 2", "type": "synonym", "evidence": [ { "id": "E1BG64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG64/entry#names_and_taxonomy" } ] }, { "name": "fasciculation and elongation protein zeta-2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001179979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179979" } ] }, { "name": "zygin 2", "type": "synonym", "evidence": [ { "id": "NP_001179979", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179979" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG64", "url": "https://www.uniprot.org/uniprotkb/E1BG64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FEZ2", "url": "https://www.uniprot.org/uniprotkb/E1BG64", "locus": { "chromosome": "11", "start_pos": 19023725, "end_pos": 19068890, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009021", "url": "https://www.ensembl.org/id/ENSBTAG00000009021" } ] } } ], "crossref": [ { "id": "E1BG64", "url": "https://alphafold.ebi.ac.uk/entry/E1BG64", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100299092", "url": "https://www.ncbi.nlm.nih.gov/gene/100299092", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299092", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299092", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YILKGTH", "url": "https://omabrowser.org/oma/group/YILKGTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGQ3", "url": "https://www.orthodb.org/?gene=A0A3Q1MGQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BG64", "url": "https://www.orthodb.org/?gene=E1BG64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12394:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12394:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179979", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGQ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG64", "url": "https://www.uniprot.org/uniprotkb/E1BG64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG64-1", "url": "https://www.uniprot.org/uniprotkb/E1BG64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAADGDWQDFYEFQEPARSLQDQENCNASPEAGAGPGGGGDGFPALACHLEEKLSLCFRPSGPAAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGMSDGLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTSSYEERVKRLSVSELNELLEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT", "length": 376, "header": "tr|E1BG64-1|E1BG64_BOVIN Isoform 1 of Fasciculation and elongation protein zeta 2 OS=Bos taurus OX=9913 GN=FEZ2 PE=3 SV=2 CANONICAL=E1BG64-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGQ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BG64/entry#A0A3Q1MGQ3-1", "sequence": { "sequence": "MAADGDWQDFYEFQEPARSLQDQENCNASPEAGAGPGGGGDGFPALACHLEEKLSLCFRPSGPAAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGMSDGLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTSSYEERVKRLSVSELNELLEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT", "length": 349, "header": "tr|A0A3Q1MGQ3-1|A0A3Q1MGQ3_BOVIN Computationally mapped isoform of Fasciculation and elongation protein zeta 2 OS=Bos taurus OX=9913 GN=FEZ2 PE=3 SV=1 CANONICAL=E1BG64-1" }, "locus": { "chromosome": "11", "start_pos": 19068871, "end_pos": 19024668, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074441.1", "url": "https://www.ensembl.org/id/ENSBTAT00000074441.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068216.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068216.1" } ] } }, { "isoform_ac": "E1BG64-1", "url": "https://www.uniprot.org/uniprotkb/E1BG64/entry#E1BG64-1", "sequence": { "sequence": "MAADGDWQDFYEFQEPARSLQDQENCNASPEAGAGPGGGGDGFPALACHLEEKLSLCFRPSGPAAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGMSDGLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTSSYEERVKRLSVSELNELLEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT", "length": 376, "header": "tr|E1BG64-1|E1BG64_BOVIN Isoform 1 of Fasciculation and elongation protein zeta 2 OS=Bos taurus OX=9913 GN=FEZ2 PE=3 SV=2 CANONICAL=E1BG64-1" }, "locus": { "chromosome": "11", "start_pos": 19068871, "end_pos": 19024668, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011880.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011880.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011880.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011880.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100299092", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299092", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P97578-1", "protein_name": "Fasciculation and elongation protein zeta-2", "gene_name": "Fez2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAADGDWQDFYEFQEPAGSVRDQENCNASPEAGAGAHAGGDSFPALASSLEEKLSLCFRPTSDADPPRAAVRPITERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLTEKGMSDGLPFDTSDEEELREQLDMHSIIVSCVNEEPLFTADQVIEEIEEMMQESPDLEDDETPTQSDRLSMLSQEIQTLKSSSMSSCEERVKRLSVSELNELLEEIETAIKEYSEELVQQLALRDELEFEKEVENSFISALIEVQNKQKEHKETAKKKKKLKNGSSQNGRNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTVIPYEKKNGPPSVEDLQILTKILHAMKEDSEKVPSLLTDYILKVLCPT", "length": 375 }, "evidence": [ { "id": "E1BG64", "url": "https://omabrowser.org/oma/group/E1BG64/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UHY8-1", "protein_name": "Fasciculation and elongation protein zeta-2", "gene_name": "FEZ2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAADGDWQDFYEFQEPARSLLDQENCNASPEPGAEAGAEAGGGADGFPAPACSLEEKLSLCFRPSDPGAEPPRTAVRPITERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT", "length": 353 }, "evidence": [ { "id": "E1BG64", "url": "https://omabrowser.org/oma/group/E1BG64/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of autophagosome assembly", "id": "GO:1902902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902902", "evidence": [ { "database": "UniProtKB", "id": "E1BG64", "url": "https://www.uniprot.org/uniprotkb/E1BG64" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BG64", "url": "https://www.uniprot.org/uniprotkb/E1BG64" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BG64", "url": "https://www.uniprot.org/uniprotkb/E1BG64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG64-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG64-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG64" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 281, "end_pos": 283 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BG98-1", "uniprot_ac": "E1BG98", "uniprot_id": "E1BG98_BOVIN", "mass": { "chemical_mass": 94672.0, "monoisotopic_mass": 94672.0 }, "refseq": {}, "gene_names": [ { "name": "INTS6L", "type": "recommended", "evidence": [ { "id": "E1BG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG98" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 6 like", "type": "synonym", "evidence": [ { "id": "E1BG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG98/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BG98", "url": "https://www.uniprot.org/uniprotkb/E1BG98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS6L", "url": "https://www.uniprot.org/uniprotkb/E1BG98", "locus": {} } ], "crossref": [ { "id": "E1BG98", "url": "https://alphafold.ebi.ac.uk/entry/E1BG98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008993", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008993", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00198", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00198", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12957:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12957:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M1H5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1H5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG98", "url": "https://www.uniprot.org/uniprotkb/E1BG98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG98-1", "url": "https://www.uniprot.org/uniprotkb/E1BG98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKVKGGEGRDGGDRGDRYMLVTYREPPYCIKAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTSGVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGLASTEPEQIGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVGHWPIPESFWPDQNLPSLPPRTSHPIVRFSCIDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLPLKKALRMMGAPNLISDNLDCGLSYSVISYLKKLSQQTKLESERILASVGKKPPQEIGIKVKNHSGGGVSLTHNKNFRKLLKEIIGDTAPRLTELNTKEFAGFQVGLLNKDLKPQTYRNFIVGQDEGNVPVAQMGNYQEYLKDIEGGIPTDEFVAGPQKKVKRPGEVNSALSSKRRRSMSLLLRKPQTPPTVTNHVGGKGPPSASWFPSYSNLIKPTLVYTGVTVTHDVHEEKMENGQISPDGFLSKSASPELMNMAGDGIPPDQVDSLSDDFTSLREDGPMHKPGSNALPGETKNCSVSVDDQKVSVTSALETVPSTLQITPAMAQGINADIKHQLMKEVRKFGRKYERIFTLLEGVQGPLAVKKQFVEFTIRKLQRFKRRVLIQYLEKVLEKIESYHLLNNYLTSCFFCYFPN", "length": 847, "header": "tr|E1BG98-1|E1BG98_BOVIN Isoform 1 of Integrator complex subunit 6 like OS=Bos taurus OX=9913 GN=INTS6L PE=4 SV=4 CANONICAL=E1BG98-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1H5-1", "url": "https://www.uniprot.org/uniprotkb/E1BG98/entry#A0A3Q1M1H5-1", "sequence": { "sequence": "MPILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKVKGGEGRDGGDRGDRYMLVTYREPPYCIKAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTSGVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGLASTEPEQIGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVGHWPIPESFWPDQNLPSLPPRTSHPIVRFSCIDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLTKLESERILASVGKKPPQEIGIKVKNHSGGGVSLTHNKNFRKLLKEIIGDTAPRLTELNTKEFAGFQVGLLNKDLKPQTYRNFIVGQDEGNVPVAQMGNYQEYLKDIEGGIPTDEFVAGPQKKVKRPGEVNSALSSKRRRSMSLLLRKPQTPPTVTNHVGGKGPPSASWFPSYSNLIKPTLVYTGVTVTHDVHEEKMENGQISPDGFLSKSASPELMNMAGDGIPPDQVDSLSDDFTSLREDGPMHKPGSNALPGETKNCSVSVDDQKVSVTSALETVPSTLQITPAMAQGINADIKHQLMKEVRKFGRKYERIFTLLEGVQGPLAVKKQFVEFTIRKLQRFKRRVLIQYLEKVLEKIESYHLLNNYLTSCFFCYFPN", "length": 810, "header": "tr|A0A3Q1M1H5-1|A0A3Q1M1H5_BOVIN Computationally mapped isoform of Integrator complex subunit 6 like OS=Bos taurus OX=9913 GN=INTS6L PE=4 SV=2 CANONICAL=E1BG98-1" }, "locus": { "chromosome": "NKLS02002208.1", "start_pos": 9090163, "end_pos": 9034094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082625.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082625.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063803.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063803.2" } ] } }, { "isoform_ac": "E1BG98-1", "url": "https://www.uniprot.org/uniprotkb/E1BG98/entry#E1BG98-1", "sequence": { "sequence": "MPILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKVKGGEGRDGGDRGDRYMLVTYREPPYCIKAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTSGVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGLASTEPEQIGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVGHWPIPESFWPDQNLPSLPPRTSHPIVRFSCIDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLPLKKALRMMGAPNLISDNLDCGLSYSVISYLKKLSQQTKLESERILASVGKKPPQEIGIKVKNHSGGGVSLTHNKNFRKLLKEIIGDTAPRLTELNTKEFAGFQVGLLNKDLKPQTYRNFIVGQDEGNVPVAQMGNYQEYLKDIEGGIPTDEFVAGPQKKVKRPGEVNSALSSKRRRSMSLLLRKPQTPPTVTNHVGGKGPPSASWFPSYSNLIKPTLVYTGVTVTHDVHEEKMENGQISPDGFLSKSASPELMNMAGDGIPPDQVDSLSDDFTSLREDGPMHKPGSNALPGETKNCSVSVDDQKVSVTSALETVPSTLQITPAMAQGINADIKHQLMKEVRKFGRKYERIFTLLEGVQGPLAVKKQFVEFTIRKLQRFKRRVLIQYLEKVLEKIESYHLLNNYLTSCFFCYFPN", "length": 847, "header": "tr|E1BG98-1|E1BG98_BOVIN Isoform 1 of Integrator complex subunit 6 like OS=Bos taurus OX=9913 GN=INTS6L PE=4 SV=4 CANONICAL=E1BG98-1" }, "locus": { "chromosome": "NKLS02002208.1", "start_pos": 9090163, "end_pos": 9034094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011843.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011843.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011843.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011843.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "E1BG98", "url": "https://www.uniprot.org/uniprotkb/E1BG98" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "E1BG98", "url": "https://www.uniprot.org/uniprotkb/E1BG98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "E1BG98", "url": "https://www.uniprot.org/uniprotkb/E1BG98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BG98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 847, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BG98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BG98" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG98" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 230, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 495, "end_pos": 497 }, { "start_pos": 728, "end_pos": 730 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGA1-1", "uniprot_ac": "E1BGA1", "uniprot_id": "E1BGA1_BOVIN", "mass": { "chemical_mass": 27903.0, "monoisotopic_mass": 27903.0 }, "refseq": { "ac": "XP_002687632", "name": "thiol S-methyltransferase TMT1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687632" }, "gene_names": [ { "name": "TMT1B", "type": "recommended", "evidence": [ { "id": "E1BGA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA1" } ] }, { "name": "TMT1B", "type": "synonym", "evidence": [ { "id": "XP_002687632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687632" } ] } ], "protein_names": [ { "name": "Thiol methyltransferase 1B", "type": "synonym", "evidence": [ { "id": "E1BGA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA1/entry#names_and_taxonomy" } ] }, { "name": "thiol S-methyltransferase TMT1B", "type": "synonym", "evidence": [ { "id": "XP_002687632", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687632" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGA1", "url": "https://www.uniprot.org/uniprotkb/E1BGA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMT1B", "url": "https://www.uniprot.org/uniprotkb/E1BGA1", "locus": { "chromosome": "5", "start_pos": 57571502, "end_pos": 57574752, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012896", "url": "https://www.ensembl.org/id/ENSBTAG00000012896" } ] } } ], "crossref": [ { "id": "E1BGA1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012896", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012896", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506952", "url": "https://www.ncbi.nlm.nih.gov/gene/506952", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506952", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506952", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPPIKWL", "url": "https://omabrowser.org/oma/group/PPPIKWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGA1", "url": "https://www.orthodb.org/?gene=E1BGA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45036:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45036:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687632", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687632", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGA1", "url": "https://www.uniprot.org/uniprotkb/E1BGA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDALVRLLQLLVFLLTLPLHLMALLGFWEPLCKTYFPYLMAVLTVKNNRVMENKKRELFSQINGLAGTSGKVALLELGCGTGANFRFYPAGCKITCLDPNPHFEKFLTKSMAENRHLEYERFVVAFGEDMRQLADGSMDAVVSTLVLCSVESPKRVLQEVRRVLRPGGVFFFWEHMAEPRGSWAFLWQQVLEPTWKHIGDGCHLTRETWRDLENAQFSELQVEQQPPPIKWLPVGPHIMGKAVK", "length": 244, "header": "tr|E1BGA1-1|E1BGA1_BOVIN Isoform 1 of Thiol methyltransferase 1B OS=Bos taurus OX=9913 GN=TMT1B PE=1 SV=1 CANONICAL=E1BGA1-1" }, "isoforms": [ { "isoform_ac": "E1BGA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGA1/entry#E1BGA1-1", "sequence": { "sequence": "MDALVRLLQLLVFLLTLPLHLMALLGFWEPLCKTYFPYLMAVLTVKNNRVMENKKRELFSQINGLAGTSGKVALLELGCGTGANFRFYPAGCKITCLDPNPHFEKFLTKSMAENRHLEYERFVVAFGEDMRQLADGSMDAVVSTLVLCSVESPKRVLQEVRRVLRPGGVFFFWEHMAEPRGSWAFLWQQVLEPTWKHIGDGCHLTRETWRDLENAQFSELQVEQQPPPIKWLPVGPHIMGKAVK", "length": 244, "header": "tr|E1BGA1-1|E1BGA1_BOVIN Isoform 1 of Thiol methyltransferase 1B OS=Bos taurus OX=9913 GN=TMT1B PE=1 SV=1 CANONICAL=E1BGA1-1" }, "locus": { "chromosome": "5", "start_pos": 57574553, "end_pos": 57572506, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017141.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017141.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017141.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017141.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506952", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506952", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W9I5-1", "protein_name": "Thiol methyltransferase 1B", "gene_name": "TMT1B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDALVRLLQLLVLLLTLPLHLMALLGLWEPLCKSYFPYVMDVLTAKNNRKIESKKRELFSQIKGLAGASGKVALLELGSGTGANFQFYPAGCRITCLDPNPHFQTFLTKSMAENRHLEYERFVVAFGEDMKELADGSMDVVVSTLVLCSVQSPKRVLQEVQRVLRPGGLFFFWEHMAEPQGSWALLWQQVLEPTWKHIADGCCLTRETRKDLESAKFSELQMEQHPPLLKWLPVGPHIMGKAVK", "length": 244 }, "evidence": [ { "id": "E1BGA1", "url": "https://omabrowser.org/oma/group/E1BGA1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HRM2-1", "protein_name": "Methyltransferase-like protein 7B", "gene_name": "Mettl7b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGVLVPFLQLLVLLLTLPLHLLALVGFWQPVCKTYFPYLMAKLTERANKKMESKKRELFSQIKDLKGTSGKVALLELGCGTGANFQFYPPNCRVTCVDPNPNFEKFLTKSMAENKHLQYERFIVAYGEDMRQLADSSMDVVVCTLVLCSVRSPKKVLQEIQRVLKPGGLLFFWEHVAEPRGSWAFLWQQVFEPTWKHIGDGCHLTRETWKDLEKARFSDVQMERQSPPFKWLPIGPHIMGKAVK", "length": 244 }, "evidence": [ { "id": "E1BGA1", "url": "https://omabrowser.org/oma/group/E1BGA1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q562C4-1", "protein_name": "Thiol S-methyltransferase TMT1B", "gene_name": "Tmt1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVLVPLLQLLVLLLTLPLHLLALLGCWQPICKTYFPYLMATLTARSYKKMESKKRELFSQIKDLKGTSNEVTLLELGCGTGANFQFYPPGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGENMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLKPGGLLFFWEHVSEPQGSQALLWQRVLEPTWKHIGDGCHLTRETWKDIEKAQFSEVQLEWQPPPFKWLPVGPHIMGKAVK", "length": 244 }, "evidence": [ { "id": "E1BGA1", "url": "https://omabrowser.org/oma/group/E1BGA1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UX53-1", "protein_name": "Thiol S-methyltransferase TMT1B", "gene_name": "TMT1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK", "length": 244 }, "evidence": [ { "id": "E1BGA1", "url": "https://omabrowser.org/oma/group/E1BGA1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DD20-1", "protein_name": "Thiol S-methyltransferase TMT1B", "gene_name": "Tmt1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDALVLFLQLLVLLLTLPLHLLALLGCWQPICKTYFPYFMAMLTARSYKKMESKKRELFSQIKDLKGTSGNVALLELGCGTGANFQFYPQGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGENMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLRPGGLLFFWEHVAEPQGSRAFLWQRVLEPTWKHIGDGCHLTRETWKDIERAQFSEVQLEWQPPPFRWLPVGPHIMGKAVK", "length": 244 }, "evidence": [ { "id": "E1BGA1", "url": "https://omabrowser.org/oma/group/E1BGA1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "thiol S-methyltransferase activity", "id": "GO:0018708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018708", "evidence": [ { "database": "UniProtKB", "id": "E1BGA1", "url": "https://www.uniprot.org/uniprotkb/E1BGA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGA1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 244, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGA1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGA1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA1" }, { "id": "PF08241", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08241" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase type 11", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 172, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGA8-1", "uniprot_ac": "E1BGA8", "uniprot_id": "E1BGA8_BOVIN", "mass": { "chemical_mass": 23555.0, "monoisotopic_mass": 23555.0 }, "refseq": { "ac": "XP_059742772", "name": "C-type lectin domain family 1 member B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742772" }, "gene_names": [ { "name": "CLEC1B", "type": "recommended", "evidence": [ { "id": "E1BGA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" } ] }, { "name": "CLEC1B", "type": "synonym", "evidence": [ { "id": "XP_059742772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742772" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 1 member B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059742772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742772" } ] }, { "name": "C-type lectin domain family 1 member B", "type": "synonym", "evidence": [ { "id": "E1BGA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGA8", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC1B", "url": "https://www.uniprot.org/uniprotkb/E1BGA8", "locus": { "chromosome": "5", "start_pos": 99904334, "end_pos": 99914703, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030423", "url": "https://www.ensembl.org/id/ENSBTAG00000030423" } ] } } ], "crossref": [ { "id": "E1BGA8", "url": "https://alphafold.ebi.ac.uk/entry/E1BGA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030423", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030423", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784092", "url": "https://www.ncbi.nlm.nih.gov/gene/784092", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BGA8", "url": "https://www.orthodb.org/?gene=E1BGA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46490", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46490", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46490:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46490:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059742772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGA8", "url": "https://www.uniprot.org/uniprotkb/E1BGA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDEDGYVTLNIKTQKPALTSVEPAPSPLWRVMALTLLVLCVGMVVGLVALGLMSVMQQNYLQAENENLSGTMKLLVKKVCQDLIQLSGQKQSHKCNPCDTHWRYYGDSCYGFFRHNLTWEESKKYCIDVNATLVKISSKSILKSSDVWRWEDGSVLSKTMLKLSGTGTENMNCAYFHNGNIHPTFCENRHYLMCERKAGVVKVEHLL", "length": 208, "header": "tr|E1BGA8-1|E1BGA8_BOVIN Isoform 1 of C-type lectin domain family 1 member B OS=Bos taurus OX=9913 GN=CLEC1B PE=4 SV=3 CANONICAL=E1BGA8-1" }, "isoforms": [ { "isoform_ac": "E1BGA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGA8/entry#E1BGA8-1", "sequence": { "sequence": "MQDEDGYVTLNIKTQKPALTSVEPAPSPLWRVMALTLLVLCVGMVVGLVALGLMSVMQQNYLQAENENLSGTMKLLVKKVCQDLIQLSGQKQSHKCNPCDTHWRYYGDSCYGFFRHNLTWEESKKYCIDVNATLVKISSKSILKSSDVWRWEDGSVLSKTMLKLSGTGTENMNCAYFHNGNIHPTFCENRHYLMCERKAGVVKVEHLL", "length": 208, "header": "tr|E1BGA8-1|E1BGA8_BOVIN Isoform 1 of C-type lectin domain family 1 member B OS=Bos taurus OX=9913 GN=CLEC1B PE=4 SV=3 CANONICAL=E1BGA8-1" }, "locus": { "chromosome": "5", "start_pos": 99914414, "end_pos": 99905338, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030538.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030538.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030517.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030517.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BGA8", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BGA8", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BGA8", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA8" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 196, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 131, "end_pos": 133 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGB7-1", "uniprot_ac": "E1BGB7", "uniprot_id": "E1BGB7_BOVIN", "mass": { "chemical_mass": 78957.0, "monoisotopic_mass": 78957.0 }, "refseq": {}, "gene_names": [ { "name": "LOC613282", "type": "recommended", "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" } ] } ], "protein_names": [ { "name": "beta-galactosidase", "type": "recommended", "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.23", "type": "synonym", "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGB7", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC613282", "url": "https://www.uniprot.org/uniprotkb/E1BGB7", "locus": {} } ], "crossref": [ { "id": "E1BGB7", "url": "https://alphafold.ebi.ac.uk/entry/E1BGB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012229", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QDRGQVF", "url": "https://omabrowser.org/oma/group/QDRGQVF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23421", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23421", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01301", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01301", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21317", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21317", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BGB7", "url": "https://www.uniprot.org/uniprotkb/E1BGB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQAFLFLVRLAGLLSLTSRFLVTSALQEGLPESVVEALLRPSHVSERLVGLQVRGSNFTLGNMPFLILSGTIHYFRVPRDYWKDSLLKLKACGFNTVTTHVPWNLHEPRRGQFHYSGNLDLIAFISLASEVDLWVILCVGPYIGSDLDLGGLPSWLLKDSHMKLRTTHKGFTAAVNRYFDDLIPKIRGFQFQEEGPIIAMQMENEYGSYNLDKRYMPYIKNALLSRGIKTMLMTADTGQGLLKGHTPTVFATLHMKSIRQKTYEHLSSAQVRTAQRRGVFSFISGSAPPSPPPAVLMESVREMLKLRFSLNFYMFHGGTNFGFTGGAAFPGHRLPMVTSYDYGALLTEDGGYTPEYLVFQEFFRVPSFQHQDHRPKDTYAPLAAGHFISLWDTLIHQDDEPVRSTGPLSMEQLSVNEGSGQSAGYILYETVITRGGILNSDGHVKDRGQVFLDDKYIGVLDDTHQKLTLPSDHYKEFLTLRILVENQGRLASGTSMNQERKGLTGNIYLNGSPLRKFKIYSLEMQNKFIQRKLPNIWKPSFLHTVGPAFFLALLRVGSQPKDTFMSLQGWTKGVVFINGQNLGRYWNVGPQETLYVPGPWLKPGLNEIIVFEEFKSTLLIYFTNTSQLGKRLPPRKQLRQLPASRGVCARFPGPGHAPPLPASPRFSWRFSRPRLLCLLLPWPLGPSWRSPGGGCAAQPGPPS", "length": 703, "header": "tr|E1BGB7-1|E1BGB7_BOVIN Isoform 1 of beta-galactosidase OS=Bos taurus OX=9913 GN=LOC613282 PE=3 SV=3 CANONICAL=E1BGB7-1" }, "isoforms": [ { "isoform_ac": "E1BGB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGB7/entry#E1BGB7-1", "sequence": { "sequence": "MQAFLFLVRLAGLLSLTSRFLVTSALQEGLPESVVEALLRPSHVSERLVGLQVRGSNFTLGNMPFLILSGTIHYFRVPRDYWKDSLLKLKACGFNTVTTHVPWNLHEPRRGQFHYSGNLDLIAFISLASEVDLWVILCVGPYIGSDLDLGGLPSWLLKDSHMKLRTTHKGFTAAVNRYFDDLIPKIRGFQFQEEGPIIAMQMENEYGSYNLDKRYMPYIKNALLSRGIKTMLMTADTGQGLLKGHTPTVFATLHMKSIRQKTYEHLSSAQVRTAQRRGVFSFISGSAPPSPPPAVLMESVREMLKLRFSLNFYMFHGGTNFGFTGGAAFPGHRLPMVTSYDYGALLTEDGGYTPEYLVFQEFFRVPSFQHQDHRPKDTYAPLAAGHFISLWDTLIHQDDEPVRSTGPLSMEQLSVNEGSGQSAGYILYETVITRGGILNSDGHVKDRGQVFLDDKYIGVLDDTHQKLTLPSDHYKEFLTLRILVENQGRLASGTSMNQERKGLTGNIYLNGSPLRKFKIYSLEMQNKFIQRKLPNIWKPSFLHTVGPAFFLALLRVGSQPKDTFMSLQGWTKGVVFINGQNLGRYWNVGPQETLYVPGPWLKPGLNEIIVFEEFKSTLLIYFTNTSQLGKRLPPRKQLRQLPASRGVCARFPGPGHAPPLPASPRFSWRFSRPRLLCLLLPWPLGPSWRSPGGGCAAQPGPPS", "length": 703, "header": "tr|E1BGB7-1|E1BGB7_BOVIN Isoform 1 of beta-galactosidase OS=Bos taurus OX=9913 GN=LOC613282 PE=3 SV=3 CANONICAL=E1BGB7-1" }, "locus": { "chromosome": "15", "start_pos": 83588365, "end_pos": 83556733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016226.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016226.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016226.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016226.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F6Y113-1", "protein_name": "Beta-galactosidase", "gene_name": "Gm1110", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWAFLGRPECILCLSSALCAMALLSNNEFSRLNQTHLTPLLLINRKVGLQVKDSQFTLEGFPFRIISGTIDYFRIPRNSWRLSLRKMQAGGFNTLTTHIPWNLHEPAVGQFYFTENTDLIAFITMASQSGLWVILCPGPYIGSDLDLGGLPSWLLKDPKMKLRTTYKGFTKAMNRYFDNLIPKIAKFQYKKGGPIIAVQVENEYGSYYMDKKYMAYVKTALVSRGIDELLMTADDGVSLRKGHLENVLATVHMKNIKKETFGDLRSIQGKSPILMMVYTTKSFDTWGTLHQTGDAQMLLKDVHEMFHLGFSLNFYMFQGGTNFGLIGGAQSSEGYKPVVTSYDYNALVSEGGEYTVQYREFQRFFHSVTDSHLTVQPKTTQMFAYQPVTLLYFMTLWEFLPNLVKTTKSSKPLSMEQLRVNERSGQSFGYILYETVIFSGGLITSRGHIRDRGQVFLDNIYIGLLDQSNSELLLYKDVSKKSQILRILVENQGRLTSGQDINKERKGLTGDIYLDKSPLRPFKIYSLEMNNIFIQREFPNSWQRVTSQVQGPAFFLSYLKAGDPPQDTFMKIQGWGKGVISINGRSLGRYWNIGPQETVFVPGSWLQPGVNKIIMFEELKGDEKIHFSTKAQLGH", "length": 635 }, "evidence": [ { "id": "E1BGB7", "url": "https://omabrowser.org/oma/group/E1BGB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "beta-galactosidase activity", "id": "GO:0004565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004565", "evidence": [ { "database": "UniProtKB", "id": "E1BGB7", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "vacuole", "id": "GO:0005773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005773", "evidence": [ { "database": "UniProtKB", "id": "E1BGB7", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "galactose catabolic process", "id": "GO:0019388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019388", "evidence": [ { "database": "UniProtKB", "id": "E1BGB7", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGB7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 703, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGB7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGB7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" }, { "id": "PF21317", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21317" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-galactosidase 1-like first all-beta", "eco_id": "ECO_0000259", "start_pos": 407, "end_pos": 523, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" }, { "id": "PF21467", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21467" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-galactosidase galactose-binding", "eco_id": "ECO_0000259", "start_pos": 547, "end_pos": 606, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGB7" }, { "id": "PF01301", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01301" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase 35 catalytic", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 362, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.23", "ec_name": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "3.2.1.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.23" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 510, "end_pos": 512 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 624, "end_pos": 626 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGC5-1", "uniprot_ac": "E1BGC5", "uniprot_id": "E1BGC5_BOVIN", "mass": { "chemical_mass": 241333.0, "monoisotopic_mass": 241333.0 }, "refseq": { "ac": "XP_002691053", "name": "YLP motif-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691053" }, "gene_names": [ { "name": "YLPM1", "type": "recommended", "evidence": [ { "id": "E1BGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ] }, { "name": "YLPM1", "type": "synonym", "evidence": [ { "id": "XP_002691053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691053" } ] } ], "protein_names": [ { "name": "YLP motif-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#names_and_taxonomy" } ] }, { "name": "Nuclear protein ZAP3", "type": "synonym", "evidence": [ { "id": "E1BGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#names_and_taxonomy" } ] }, { "name": "YLP motif-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691053" } ] } ], "function": [ { "annotation": "Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5#function" }, { "database": "UniProtKB", "id": "ARBA00058677", "url": "https://www.uniprot.org/uniprotkb/ARBA00058677#function" }, { "database": "UniProtKB", "id": "A0AAA9S662", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S662#function" }, { "database": "UniProtKB", "id": "A0A3Q1MZ61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ61#function" }, { "database": "UniProtKB", "id": "A0AAA9S1U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1U7#function" }, { "database": "UniProtKB", "id": "A0AAA9S5U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5U6#function" }, { "database": "UniProtKB", "id": "A0AAA9SU28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YLPM1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5", "locus": { "chromosome": "10", "start_pos": 86109580, "end_pos": 86019651, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008287", "url": "https://www.ensembl.org/id/ENSBTAG00000008287" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008287", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008287", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540849", "url": "https://www.ncbi.nlm.nih.gov/gene/540849", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540849", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540849", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HEDDRMQ", "url": "https://omabrowser.org/oma/group/HEDDRMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGC5", "url": "https://www.orthodb.org/?gene=E1BGC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13413", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13413", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13413:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13413:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13671", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13671", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691053", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691053", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZ61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZ61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S662", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S662", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S662-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S662-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGC5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPGGLQGSQDRGRAGSRERGPPRRAGSQERGPPRRPGSRERVPPRRAGSRERGLPRGPGGRERGLGRPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI", "length": 2145, "header": "tr|E1BGC5-1|E1BGC5_BOVIN Isoform 1 of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=3 CANONICAL=E1BGC5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MZ61-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#A0A3Q1MZ61-1", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI", "length": 1442, "header": "tr|A0A3Q1MZ61-1|A0A3Q1MZ61_BOVIN Computationally mapped isoform of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=1 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86083222, "end_pos": 86019850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082781.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082781.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061452.1" } ] } }, { "isoform_ac": "A0AAA9S1U7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#A0AAA9S1U7-1", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPGGLQGSQDRGRAGSRERGPPRRAGSQERGPPRRPGSRERVPPRRAGSRERGLPRGPGGRERGLGRPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELGYIPKSKWEMDTSEAKLGRICVFA", "length": 2060, "header": "tr|A0AAA9S1U7-1|A0AAA9S1U7_BOVIN Computationally mapped isoform of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=1 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86108473, "end_pos": 86019850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093567.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093567.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077282.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077282.1" } ] } }, { "isoform_ac": "A0AAA9S5U6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#A0AAA9S5U6-1", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPGGLQGSQDRGRAGSRERGPPRRAGSQERGPPRRPGSRERVPPRRAGSRERGLPRGPGGRERGLGRPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELTSWMA", "length": 2041, "header": "tr|A0AAA9S5U6-1|A0AAA9S5U6_BOVIN Computationally mapped isoform of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=1 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86078337, "end_pos": 86019850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090900.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090900.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081300.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081300.1" } ] } }, { "isoform_ac": "A0AAA9S662-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#A0AAA9S662-1", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPGGLQGSQDRGRAGSRERGPPRRAGSQERGPPRRPGSRERVPPRRAGSRERGLPRGPGGRERGLGRPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELEGSASLPEETALKNSCKVKLAISKKQSGTCIPKETHEKEKT", "length": 2077, "header": "tr|A0AAA9S662-1|A0AAA9S662_BOVIN Computationally mapped isoform of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=1 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86108576, "end_pos": 86019850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117210.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117210.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079329.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079329.1" } ] } }, { "isoform_ac": "A0AAA9SU28-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#A0AAA9SU28-1", "sequence": { "sequence": "MELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI", "length": 1938, "header": "tr|A0AAA9SU28-1|A0AAA9SU28_BOVIN Computationally mapped isoform of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=1 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86083222, "end_pos": 86020273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115737.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115737.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086622.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086622.1" } ] } }, { "isoform_ac": "E1BGC5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC5/entry#E1BGC5-1", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPGMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELDSPPESPPVPPGSYMPPSQSYLPPPQPPPSYYPPASSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYMSHSQSYLPSSQASPSRPSQGHSKPQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSAEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDAAEPVKEEVTVPATSQVPEPSASEEPPLPPTNEDAAPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQVIQHPPHIQTMSVDVQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQDKVSALQNVKNQYMGNMSMPPPFVPYSQMPPPPPTMPPPVLPPSLPPPVMPPALPSVPPPGMPPPVMPPSLPSSVPPPVMPPSLSSTGPPPVLPPPSLSSAGPPPVLPPPSLASTAPPPVMPLAPLSSATPPPGIPPPGVPQGMPPPLTAAPVPPASSSQNSQVPEKPRPALLPTPVSFGSAPPSVYHPPLQSALGPSDQVNSKAPLSKSALPYSSFSSEQGLGESSAAPSQPLATVKDMPGRSGGLLPDPPRSSYLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPNTSLSPRQSGPQWKGPKPTFGQQHQQQPKSQAEPGNKEPLADTSSNQQKNFKMQSATFPIAADVKDGKAAQSNENLSDSQQEPPKSEVSEGPIEPSDWDQDSHSMETQMDKSQAVTHPVPLANKAVPSQSTFPSKTGGMEGGTAVATSSSLTADNDFKPLGIGLPHSENNQDKGLPRPDNRDNRLEGNQGSSSSYRGPGQSRMEDTRDKGLVSRDRGQAISHGPGLIKQEDFRDKMMGRREDSREKMSRGEGSRDRGLVRPGSTREKVPGGLQGSQDRGRAGSRERGPPRRAGSQERGPPRRPGSRERVPPRRAGSRERGLPRGPGGRERGLGRPEFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECEHDYQDDTLDPYNREDRFSAPSRSHDGDRRGPWWDDWERDQDMDEDYNREMDRDMDRDVDRIGRPVDMYDRNLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPMDRYRDDRWREERNRDHGYDQDFRDRGELRIREYPERRDIWREKRDYIPNRMDWERERLSDRWYPSDVDRHSPMAEHMPSHHSSEMMGSDANLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDYGSEPQMPDHLPPQDSRLQSTPSRPGLYPPPGSYRPPPPMGKPPGSIVRPPAPPARSSVPVTRPPIPIPPPPPPPPPPPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSEPAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRDRDREPYFDRQSNVMADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRTQSYRDKKEHSSSRRGGFDRPSYDRKSDRPAYEGPSMFGGERRSYPEERMPLPAPSISHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKDEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI", "length": 2145, "header": "tr|E1BGC5-1|E1BGC5_BOVIN Isoform 1 of YLP motif-containing protein 1 OS=Bos taurus OX=9913 GN=YLPM1 PE=4 SV=3 CANONICAL=E1BGC5-1" }, "locus": { "chromosome": "10", "start_pos": 86083222, "end_pos": 86019850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010906.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010906.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010906.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010906.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 205, "start_aa": "Thr", "end_pos": 205, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr205", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 533, "start_aa": "Thr", "end_pos": 533, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr533", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540849", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540849", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F6P6X1-1", "protein_name": "YLP motif-containing protein 1", "gene_name": "ylpm1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MHPSWGGFGGGHQPPPHFGPRPHQFRAAQPPPPTTAPPPQPAGAPPPGGGGFAGYGAPSFPPSNFSSLHEQHLQQMQQLQQLHQKQLQSVLHHSGNNSNSPSPYWQAGGAGPAAPPNSFQAAGPQPQPPPPEVKPPAPEPPPPAPAASKPPAASTPQVSDASAPVGDEKPDFSKMSMQEQQEYWYQQHLQNLQKLKNEKAKQNQGSFNESHASAPPPPVEPPKSTPPPPPPKEEPPPPPPPDESQSSSVNNTGDPAEAARLQQLQVAAAQWQQVQHQRASFQYQALMQEHAQLQQILQQYQQVIQQPAHLQTMPFEMQLQHYEMQQQRFAPLYQEWERHFNLWLEQFQMYPHKDQLHDYEAQWRQWQEQMNSTSAHLQERVTTLRAMQHQYGSSYGMMGSYGQQSPNVQMGPNGNMNLVGPGTPSMPPPVTMDAMPAPSTQGPSQSGPVVPQGHSPSDLESISETCKTGLPPGHGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVGPPGPGAGPGVGQPRPGVRPPGPGVGPPGPQGVRPYGPGGRPPGPGVRPSGPGSGPPGPHGRFDGPRFEGPRGPQFEQPPQQRFSGPPRFDAGQRFSQPPRGNPPFPGAPARLENPPRQNTPTRFERPPVASQQTGSGQQSSPVTGNQTKQQSAKPEAKPVPPSYTDPDKAKSPLSQSTQKENNSSAPSMTDDLVDSVDGFFIQSGPIPQTKDSDKTDADSAKQDKTKEVTTKPSAPTDAPDTTNKNSNLQPPKTSHTANGPPQQVKPPQNKFKPDTPKETPRMLPMMNQQVPPQMARGRGRGQIPMPLRGRGRARGRGQYGGPMADPNFQREIEEDSYDHQEPGNASHGEDQDRIWRDPSLDGPEEIDQEAPLEIWQPEEEHFPEEYPEDTHQDENWEEEPQDYWEEEDPYWAEQRPAMRARPPFPPGGPRRPPFHPRFMLQGPRRPPPPGSLQHNPLGPPPFRPRGGVVPRFRRGLGPWGPLPRHDMMERDLRRPPAPHEIIAREPAGPHGYEEEIDREPAWPHPRGRGIRRPPLPPHEMGRGIRRPPMRPAMPRERWHGPPPHEEENYEEEYPYGAEDDVYRRPPHEYNEDYEHGDEYYGSREEWDGEQPERDYPPHRPPERVREDPWLEERERSFPYEEDRYREERRGPFYPDDPPYQDRDREPPFHSRSDWERPPPPPPPERGYSRSLSETDYEHKLDPLASLPAPQATDSPLDESSPSATKAVLALSQRQHEIILKAAQELKMIRELQETKKALGEVSTTESAGLPSELPAGILGLEIPPEVKSALQATNLLSETGQTFNAGLSSNQSTDFLSSTAPTASFIAKTVDYAHGRDGGSTVERISYGERVLLRPAPAPSERSYEKELLGHRDPYYDRRSDPYAARDYDREWERDPYREKPTLDYERDRYERDRYLRDERASLGPRPTYREREREHSSRSSRDRELYNRPSYERSSYERSLEHYEHGSSSYGERRSYPDERQPPPTSLPPSAPVAPPVEKKPEIKNAEDILKPPGRSSRPDRIVVIMRGLPGSGKSHVAKLIRDKEVECGGAPPRVLGLDDYFMTEVEKIEKDPDSGKRIKTKVLEYEYEPEMEDTYRSSMLKTFKKTLDDGFFPFIILDAINDKVKYFDQFWSAAKTKGFEVYLAEITTDQQTCAKRNIHGRTLKDISKLSGGWESAPPHMVRLDIRSLLQDAAIEDVEMEDFNPSDEPKAEVKNDDDETDLGYVPKSKWEMDTSEAKLDKLDGLVGGGKRKRDAGLSGMEDFLQLPDDYATRMSEPGKKRVRWADLEEQKDVDRKRAIGFVVGQTDWEKITDESGQIAQRALNRTKYF", "length": 1850 }, "evidence": [ { "id": "E1BGC5", "url": "https://omabrowser.org/oma/group/E1BGC5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P0CB49-1", "protein_name": "YLP motif-containing protein 1", "gene_name": "Ylpm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPVPPPPPPVALPEASPGPGYSSSTAPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMIHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPSSAQPYLPPAQPSPSKPQLPPPPPSIPSGNKTTIQQEPLETGAKNKNAEQKQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGLVTAKDVPEPIKEEAPVPATSQIAEPLAAEEPPLPPPNEEMPPPLPPEEPQNNSSEMSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQRHTQLQQILQQYQQVIQHSPHIQTMSLDVQLRHYEMQQQQFQRLYQEWEREFQLWEEQLHSYPHKDQLEEYEKQWKSWQGHMRATQTYLQEKVTSFQAVKNQYMGNMAMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPSTIPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAVLPPPSLSSAGPPPVLPPPSLSGAPPVLPLPPLSSATPPPGIPPPGVPQGMPPQLTAPVPPASSSQNSQVPEKPRQALLPTPVSFGSTPPSPYHPPPQSEQGNSKPLNKVFSSEQGLGESSSALSQSVIAAKDTPVKSGGLLADPPKGSFLEGPRGPREQKEQLQKLKDFGSEPQTADHLPPPDSRLQNTSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSCVPMTRPPVPIPPPPPPPPPPPPPPPVIKPKTSSVKQERWDEDSFFGLWDTNDDQGLNSEFKRDTAAIPSAPVLPPPPVHPSIPPPGPMPMGMPPMSKPPPVQHTVDYGHGRDMPTNKVEQIPYGERITLRPDPLPERSAFDADHAGQRDRYDRDRDREPYFDRQSNMTDHRDFKRDRETHRDRDRVLDYERDRFDRERRPRDDRNQSYRDKKDHSSSRRGGFDRPSYDRKSDRPPYEGPPMFGGERRTYPEERMPLPAPSLGHQPPPVPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFIAEVEKEEKDPDSGKKVKKKVMEYEYEADMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMAEHWEAAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEDQKEEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYETRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAERALNRTKYI", "length": 1376 }, "evidence": [ { "id": "E1BGC5", "url": "https://omabrowser.org/oma/group/E1BGC5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P49750-4", "protein_name": "YLP motif-containing protein 1", "gene_name": "YLPM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPPLPPPNEEVPPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQIIQPPPHIQTMSVDMQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQSYLQEKVNSFQNMKNQYMGNMSMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYLESPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPSTSLSPRQSGPQWKGPKPAFGQQHQQQPKSQAEPLSGNKEPLADTSSNQQKNFKMQSAAFSIAADVKDVKAAQSNENLSDSQQEPPKSEVSEGPVEPSNWDQNVQSMETQIDKAQAVTQPVPLANKPVPAQSTFPSKTGGMEGGTAVATSSLTADNDFKPVGIGLPHSENNQDKGLPRPDNRDNRLEGNRGNSSSYRGPGQSRMEDTRDKGLVNRGRGQAISRGPGLVKQEDFRDKMMGRREDSREKMNRGEGSRDRGLVRPGSSREKVPGGLQGSQDRGAAGSRERGPPRRAGSQERGPLRRAGSRERIPPRRAGSRERGPPRGPGSRERGLGRSDFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYWRECERDYQDDTLELYNREDRFSAPPSRSHDGDRRGPWWDDWERDQDMDEDYNREMERDMDRDVDRISRPMDMYDRSLDNEWDRDYGRPLDEQESQFRERDIPSLPPLPPLPPLPPLDRYRDDRWREERNREHGYDRDFRDRGELRIREYPERGDTWREKRDYVPDRMDWERERLSDRWYPSDVDRHSPMAEHMPSSHHSSEMMGSDASLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDFGSEPQMADHLPPQESRLQNTSSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSIPPPGPVPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRYDRERDREPYFDRQSNVIADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRAQSYRDKKDHSSSRRGGFDRPSYDRKSDRPVYEGPSMFGGERRTYPEERMPLPAPSLSHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMADHWETAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKEEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI", "length": 2146 }, "evidence": [ { "id": "E1BGC5", "url": "https://omabrowser.org/oma/group/E1BGC5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0I7-1", "protein_name": "YLP motif-containing protein 1", "gene_name": "Ylpm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYPNWGRYGGSSHYPPPPVPPPPPPVALPEASPGPGYSSSTAPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMIHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPSSAQPYLPPAQPGPSKPQLPPPPSIPSGNKTAIQQEPLESGAKNKTAEQKQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGLVTAKDVPEPIKEEAPGPAASQVAEPLAAEKPPLPPPNEEAPPPLSPEEPQSEDSEDSEDSEEDARFKQLKAIAAHWQAAAAHWQQQQQQRVGFQYQGIMQRHTQLQQILQQYQQVIQHSPHIQTMSLDVQLRHYEMQQQQFQHLFQDWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQEKVNSFQTVKSQYLGNMAMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPTSIPPPGMPPPVMPPSLPTSVPPPGMPPSLSSGPPPVLPPPALSSAGSPPVLPPPALPGGPPILPLPPLSSATPPPGIPPPGAPQGMPPQLTAPLPPASGSQNSQIPEKPRQALLPTPVSFGSTPPSPYHPPPQSEQVNSKPLNKVFSSEQGLGESSALSQSIIAAKDTPVKSGGLLADPPKGSFLEGPRGPREQKEQLQKLKDFGSEPQMADHLPPPDSRLQNPSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSIPMTRPPVPIPPPPPPPPPPPPPPPVIKSKTSSVKQERWDEDSFFGLWDTNDDQGLNSEFKRDTATIPSAPVLPPPPVHSSIPPPGPMPMGMPPMSKPPPVQHTVDYGHGRDMPTNKVEQIPYGERITLRPDPLPERSTFDADHAGQRDRYDRDRDREPYFDRPSNITDHRDFKRDRETHRDRDRDRVLDYERDRFDRERRPRDDRNQSYRDKKDHSSSRRGGFDRPSYDRKSDRPPYEGPPMFGGERRTYPEERMPLPAPALGHQPPPVPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVEFGGPAPRVLSLDDYFIAEVEKEEKDPDSGKKVKKKVMEYEYEADMEETYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEINKMAEHWEVAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEDQKEEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYETRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAERALNRTKYI", "length": 1386 }, "evidence": [ { "id": "E1BGC5", "url": "https://omabrowser.org/oma/group/E1BGC5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of telomere maintenance", "id": "GO:0032204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032204", "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1BGC5", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1963, "end_pos": 1965, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2140, "end_pos": 2142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 826, "end_pos": 828, "annotation": "n_glycosylation_sequon" }, { "start_pos": 900, "end_pos": 902, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGC5" }, { "id": "PF26583", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26583" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YLPM1-like spectrin repeat", "eco_id": "ECO_0000259", "start_pos": 396, "end_pos": 513, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 205, 533 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1963, "end_pos": 1965 }, { "start_pos": 2140, "end_pos": 2142 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 514, "end_pos": 516 }, { "start_pos": 826, "end_pos": 828 }, { "start_pos": 900, "end_pos": 902 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGD1-1", "uniprot_ac": "E1BGD1", "uniprot_id": "E1BGD1_BOVIN", "mass": { "chemical_mass": 34743.0, "monoisotopic_mass": 34743.0 }, "refseq": {}, "gene_names": [ { "name": "TOMM34", "type": "recommended", "evidence": [ { "id": "E1BGD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ] } ], "protein_names": [ { "name": "Mitochondrial import receptor subunit TOM34", "type": "recommended", "evidence": [ { "id": "E1BGD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD1/entry#names_and_taxonomy" } ] }, { "name": "Translocase of outer membrane 34 kDa subunit", "type": "synonym", "evidence": [ { "id": "E1BGD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1#function" }, { "database": "UniProtKB", "id": "ARBA00056353", "url": "https://www.uniprot.org/uniprotkb/ARBA00056353#function" }, { "database": "UniProtKB", "id": "A0ABI0NLH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLH2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM34", "url": "https://www.uniprot.org/uniprotkb/E1BGD1", "locus": { "chromosome": "13", "start_pos": 73347045, "end_pos": 73367085, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003256", "url": "https://www.ensembl.org/id/ENSBTAG00000003256" } ] } } ], "crossref": [ { "id": "E1BGD1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003256", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003256", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ECTTYTN", "url": "https://omabrowser.org/oma/group/ECTTYTN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGD1", "url": "https://www.orthodb.org/?gene=E1BGD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45984:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45984:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0ABI0NLH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLH2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPIPPASVEELRTTGNQSFRNGQFAEAATLYSRALRMLQEQGSSDPEKESVLYSNRAACHLKDGNCIDCIKDCTSALALVPFSLKPLLRRASAYEALEKYPLAYVDYVTVLQIDDSVMSALEGSSRMTRTLMDSFGPEWRLKLPSIPLVPVSSQKRWECLPLENHKEPSKSKSKGTTSTKSRVPSAGDVERARALKEEGNELVKKGNHKQAIEKYSESLWFSNLESATYSNRALCHLELKQYQEVVKDCTEALRLDGKNVKAFYRRAQAYKALKDFRSSFADIDSLLQIEPRNGPAQKLRQEVNRSLN", "length": 309, "header": "tr|E1BGD1-1|E1BGD1_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM34 OS=Bos taurus OX=9913 GN=TOMM34 PE=3 SV=2 CANONICAL=E1BGD1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NLH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1/entry#A0ABI0NLH2-1", "sequence": { "sequence": "MAPIPPASVEELRTTGNQSFRNGQFAEAATLYSRALRMLQEQGSSDPEKESVLYSNRAACHLKDGNCIDCIKDCTSALALVPFSLKPLLRRASAYEALEKYPLAYVDYVTVLQIDDSVMSALEGSSRMTRTLMDSFGPEWRLKLPSIPLVPVSSQKRWECLPLENHKEPSKSKSKGTTSTKSRVPSAGDVERARALKEEGNELVKKGNHKQAIEKYSESLWFSNLESATYSNSHWGRGLKLNKKDTHKALCHLELKQYQEVVKDCTEALRLDGKNVKAFYRRAQAYKALKDFRSSFADIDSLLQIEPRNGPAQKLRQEVNRSLN", "length": 324, "header": "tr|A0ABI0NLH2-1|A0ABI0NLH2_BOVIN Computationally mapped isoform of Mitochondrial import receptor subunit TOM34 OS=Bos taurus OX=9913 GN=TOMM34 PE=3 SV=1 CANONICAL=E1BGD1-1" }, "locus": { "chromosome": "13", "start_pos": 73366977, "end_pos": 73347971, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141856.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141856.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105615.1" } ] } }, { "isoform_ac": "E1BGD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1/entry#E1BGD1-1", "sequence": { "sequence": "MAPIPPASVEELRTTGNQSFRNGQFAEAATLYSRALRMLQEQGSSDPEKESVLYSNRAACHLKDGNCIDCIKDCTSALALVPFSLKPLLRRASAYEALEKYPLAYVDYVTVLQIDDSVMSALEGSSRMTRTLMDSFGPEWRLKLPSIPLVPVSSQKRWECLPLENHKEPSKSKSKGTTSTKSRVPSAGDVERARALKEEGNELVKKGNHKQAIEKYSESLWFSNLESATYSNRALCHLELKQYQEVVKDCTEALRLDGKNVKAFYRRAQAYKALKDFRSSFADIDSLLQIEPRNGPAQKLRQEVNRSLN", "length": 309, "header": "tr|E1BGD1-1|E1BGD1_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM34 OS=Bos taurus OX=9913 GN=TOMM34 PE=3 SV=2 CANONICAL=E1BGD1-1" }, "locus": { "chromosome": "13", "start_pos": 73366977, "end_pos": 73347971, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004220.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004220.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004220.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004220.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BPA2-1", "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "TOMM34", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPKLPGSVEELRAAGNQSFRNGQFAEAATLYSRALRMLQAQGSLDPEKESVLFSNRAACHLKDGNCVDCIKDCTSALALVPFSMKPLLRRASAYEALEKYPLAYVDYVTVLQIDDGVTSALEGSSRMTRALMDSFGSEWRLKLPSIPLVPVSAQKRWECLPSENRKETAKSKSKETTTAKSRVPSAGDVERARVLKEEGNELVKKGNHKQAIEKYSESLWFSNMESATYSNRALCHLVLKQYKEAVKDCTEALRLDGRNVKAFYRRAQAYKALKDYTSSFADINSLLQIEPRNGPAQKLRQEVNRSLN", "length": 309 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZKZ6-1", "protein_name": "Translocase of outer mitochondrial membrane 34", "gene_name": "TOMM34", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESAGDLRSAGNEEFRRGQYGAAAELYSRALAVLEDAGEAAAEERSVLLANRAACQLRDGACRGCVADCCSALSLTPFAIKPLLRRAAAYEALESFALAYVDYKTALQVDCSIQAAHDGVNRMTKALLEKHGVNWREKLPPIPTVPIDAQRRWSVPSAGSPTGGAPPGNTPRGDPAQTAAGIERAQTLKEEGNKLVKKGNHKKAIEKYSESLKLNQECATYTNRALCYLTLKQHKEAVQDCTEALRLDPKNVKAFYRRAQALKELKDYKSSIADINSLLKIEPKNTAALRLLQELNRA", "length": 298 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q15785-1", "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "TOMM34", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPKFPDSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCIKDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPSAGDVEKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNLH", "length": 309 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3KRD5-1", "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "Tomm34", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPKVSDSVEQLRAAGNQNFRNGQYGEASALYERALRLLQARGSADPEEESVLYSNRAACYLKDGNCTDCIKDCTSALALVPFSIKPLLRRASAYEALEKYSLAYVDYKTVLQIDNSVASALEGINRITRALMDSLGPEWRLKLPPIPVVPVSAQKRWSSLPSENHKETAKSKSKETTATKNRVPSAGDVERARVLKEEGNELVKKGNHKKAIEKYSESLLFSSLESATYSNRALCHLVLKQYKEAEKDCTEALKLDGKNVKAFYRRAQAYKALKDYKSSLADISSLLQIEPRNGPAHKLRQEVNQNMN", "length": 309 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZM24-1", "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "tomm34", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQKRRTQSWTDLKQAGNECFKAGQYGEAVTLYSQAIQQLEKSGQKKTEDLGILYSNRAASYLKDGNCNECIKDCTASLDLVPFGFKALLRRAAAFEALERYRQAYVDYKTVLQIDWNIPAAHDGVNRMTKALTEMDGPSWREKLPPIPTVPMSVKEKLGQAASPASSSQQNNVIDDKKKAPGPDAVKKGRTLKEEGNALVKKGEHKKAMEKYTQSLAQDPTEVTTYTNRALCYLALKMYKDAIRDCEEALRLDSANIKALYRRAQAYKELKNKKSCIEDLNSVLKIDPNNTAVQKLLQEVQKMK", "length": 305 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CYG7-1", "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "Tomm34", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPKVSDSVEQLRAAGNQNFRNGQYGEASALYERALRLLQARGSADPEEESVLYSNRAACYLKDGNCTDCIKDCTSALALVPFSIKPLLRRASAYEALEKYALAYVDYKTVLQIDNSVASALEGINRITRALMDSLGPEWRLKLPPIPVVPVSAQKRWNSLPSDNHKETAKTKSKEATATKSRVPSAGDVERAKALKEEGNDLVKKGNHKKAIEKYSESLLCSSLESATYSNRALCHLVLKQYKEAVKDCTEALKLDGKNVKAFYRRAQAYKALKDYKSSLSDISSLLQIEPRNGPAQKLRQEVNQNMN", "length": 309 }, "evidence": [ { "id": "E1BGD1", "url": "https://omabrowser.org/oma/group/E1BGD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "heat shock protein binding", "id": "GO:0031072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein targeting to mitochondrion", "id": "GO:0006626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006626", "evidence": [ { "database": "UniProtKB", "id": "E1BGD1", "url": "https://www.uniprot.org/uniprotkb/E1BGD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGD1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 305, "end_pos": 307 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGE0-1", "uniprot_ac": "E1BGE0", "uniprot_id": "E1BGE0_BOVIN", "mass": { "chemical_mass": 178297.0, "monoisotopic_mass": 178297.0 }, "refseq": { "ac": "XP_059731736", "name": "multiple epidermal growth factor-like domains protein 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731736" }, "gene_names": [ { "name": "MEGF6", "type": "recommended", "evidence": [ { "id": "E1BGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ] }, { "name": "MEGF6", "type": "synonym", "evidence": [ { "id": "XP_059731736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731736" } ] } ], "protein_names": [ { "name": "Multiple EGF like domains 6", "type": "synonym", "evidence": [ { "id": "E1BGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#names_and_taxonomy" } ] }, { "name": "multiple epidermal growth factor-like domains protein 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731736" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEGF6", "url": "https://www.uniprot.org/uniprotkb/E1BGE0", "locus": { "chromosome": "16", "start_pos": 49537218, "end_pos": 49436500, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020839", "url": "https://www.ensembl.org/id/ENSBTAG00000020839" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616459", "url": "https://www.ncbi.nlm.nih.gov/gene/616459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616459", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616459", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N5V6", "url": "https://www.orthodb.org/?gene=A0A3Q1N5V6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24043:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24043:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731736", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731736", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJT5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5V6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5V6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5V6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSGAQDSALPSSAGSKPGSCPPAATSRSAGPGAAPVAAPAGSPGPWRTWRRRLRAPAWAACERGTVGGTRRDAAGTMPFLPEAGAAGRAVALALVLLLPAVPTGAGALLRLQPGMPHVCAEQELTLVGRRQPCVRAFSRTVPVWRPGCGRQAWCVSHERRTVYYTGYRQVYSTEAQTVFRCCPGWSQQPGSQGCLSPVCSSGLCFNGGHCVSGSAQPCRCPSGFQGPRCQHDVNECATGNAGCEGECHNTVGGFYCRCPPGRQLQGDGKTCRDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1721, "header": "tr|E1BGE0-1|E1BGE0_BOVIN Isoform 1 of Multiple EGF like domains 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=3 CANONICAL=E1BGE0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJT5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#A0A3Q1MJT5-1", "sequence": { "sequence": "MHSGAQDSALPSSAGSKPGSCPPAATSRSAGPGAAPVAAPAGSPGPWRTWRRRLRAPAWAACERGTVGGTRRDAAGTMPFLPEAGAAGRAVALALVLLLPAVPTGAGALLRLQPGMPHVCAEQELTLVGRRQPCVRAFSRTVPVWRPGCGRQAWCVSHERRTVYYTGYRQVYSTEAQTVFRCCPGWSQQPGSQGCLSPVCSSGLCFNGGHCVSGSAQPCRCPSGFQGPRCQHDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1664, "header": "tr|A0A3Q1MJT5-1|A0A3Q1MJT5_BOVIN Computationally mapped isoform of Multiple EGF like domains 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=2 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49436590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080929.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080929.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069451.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069451.2" } ] } }, { "isoform_ac": "A0A3Q1N5V6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#A0A3Q1N5V6-1", "sequence": { "sequence": "MHSGAQDSALPSSAGSKPGSCPPAATSRSAGPGAAPVAAPAGSPGPWRTWRRRLRAPAWAACERGTVGGTRRDAAGTMPFLPEAGAAGRAVALALVLLLPAVPTGAGALLRLQPGMPHVCAEQELTLVGRRQPCVRAFSRTVPVWRPGCGRQAWCVSHERRTVYYTGYRQVYSTEAQTVFRCCPGWSQQPGSQGCLSPVCSSGLCFNGGHCVSGSAQPCRCPSGFQGPRCQHDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1680, "header": "tr|A0A3Q1N5V6-1|A0A3Q1N5V6_BOVIN Computationally mapped isoform of Multiple EGF like domains 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=1 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49436590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087360.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087360.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065706.1" } ] } }, { "isoform_ac": "A0AAA9RW09-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#A0AAA9RW09-1", "sequence": { "sequence": "MEAPWRRGGLAALWYLGLLGSLARVAGMHYRYLWRGCYPCHLGQAGYPVSSGDPRPDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1504, "header": "tr|A0AAA9RW09-1|A0AAA9RW09_BOVIN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=1 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49497573, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122646.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122646.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075291.1" } ] } }, { "isoform_ac": "A0AAA9RYS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#A0AAA9RYS4-1", "sequence": { "sequence": "MPFLPEAGAAGRAVALALVLLLPAVPTGAGALLRLQPGMPHVCAEQELTLVGRRQPCVRAFSRTVPVWRPGCGRQAWCVSHERRTVYYTGYRQVYSTEAQTVFRCCPGWSQQPGSQGCLSPVCSSGLCFNGGHCVSGSAQPCRCPSGFQGPRCQHDVNECATGNAGCEGECHNTVGGFYCRCPPGRQLQGDGKTCRDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1601, "header": "tr|A0AAA9RYS4-1|A0AAA9RYS4_BOVIN Computationally mapped isoform of Multiple EGF like domains 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=1 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49436821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092836.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092836.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078720.1" } ] } }, { "isoform_ac": "A0AAA9TDA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#A0AAA9TDA1-1", "sequence": { "sequence": "MEAPWRRGGLAALWYLGLLGSLARVAGMHYRYLWRGCYPCHLGQAGYPVSSGDPRPDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1461, "header": "tr|A0AAA9TDA1-1|A0AAA9TDA1_BOVIN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=1 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49497573, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096095.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096095.1" } ] } }, { "isoform_ac": "E1BGE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE0/entry#E1BGE0-1", "sequence": { "sequence": "MHSGAQDSALPSSAGSKPGSCPPAATSRSAGPGAAPVAAPAGSPGPWRTWRRRLRAPAWAACERGTVGGTRRDAAGTMPFLPEAGAAGRAVALALVLLLPAVPTGAGALLRLQPGMPHVCAEQELTLVGRRQPCVRAFSRTVPVWRPGCGRQAWCVSHERRTVYYTGYRQVYSTEAQTVFRCCPGWSQQPGSQGCLSPVCSSGLCFNGGHCVSGSAQPCRCPSGFQGPRCQHDVNECATGNAGCEGECHNTVGGFYCRCPPGRQLQGDGKTCRDVDECQVHNGGCQHRCVNTPGSYFCECKPGFRLHADGRTCLAINSCAVGNGGCQHNCVQLTVTQHRCQCRPEFQLQEDGRRCVRRNPCADRNGGCMHRCRALRGLAHCECRAGYQLAVDRKACEDVDECATGLAQCAHGCLNTHGSFKCVCNAGYELGADGRQCYRIEMEIVNSCEADNGGCSHGCSHSSAGPVCTCPHGYELDEDQRTCIDVDDCAASPCCQQVCTNSPGGYECSCYAGYRLSADGCGCEDVDECASGRGGCEHHCANLAGSFQCSCEAGYQLDEDRRGCTSLELPELVLDGHLPLGRPPLHVAVLQDELPHLFQDDYVGAEEEEAEARGEHTLQEKYVCLDDTFGPDCSLTCDDCRNGGTCLPTLDSCDCPDGWTGLVCNETCPPDTFGKNCSFSCSCQNGGTCDPVTGACRCPPGVGGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECKCEQQNTRACDKRDGSCACKAGFRGEWCQDECQPGFFGPGCRQACTCPPGVACDPVSGECGKQCPAGYHGEDCGQECPAGTFGQNCSGSCSCGDAPCDRVTGQCLCPPGRTGDDCGADCPEGRWGLGCQEICPPCEHGAACVPETGACLCRPGFMGSRCQDACPAGWFGPGCQTQCSCANDGLCHPVTGRCSCAPGWTGLSCQRACDSGHWGPDCSFTCNCSAGHGGCDAVSGLCVCEAGYVGPRCEQRCPQGYFGPGCGRQCQCEHGAACDHVSGACTCPAGWRGTFCERACPAGFFGVDCGHACDCSAGVPCDPVSGSCLCPSGRQGPRCAQTCPAHMFGHNCSQACSCFNGASCDPVHGQCRCGPGWTGPTCLQACPEGLYGEDCQHSCLCQNGGSCDPVSGHCTCPEGWAGLACEKECLPGVFEVGCPHSCGCLNGGLCDPHTVHCLCPAGWTGDKCQSSCPEGTFGVLCEERCACRWGAACHAVTGACLCAPGWRGSRCESACPPSWFGEACAQRCQCPPGAACHHVTGECHCPPGFTGPSCEQACPPGTFGERCGQQCHCPGENQACHPASGTCACAPGYHGAGCQQRCPPGRFGPGCELLCGCLNGGSCDAVTGACRCPAGFLGTDCSLACPHGRFGPGCAYVCGCGQGAACDPVTGSCSCPPGRTGVHCEHGCPQNRFGVNCEHACSCRNGGLCHATNGSCSCGLGWTGPHCELACPAGRYGAACSLECSCHNHGACEPTSGACRCGPGFYGQACEHSCPPGFHGAGCQQTCQCQHGAPCDPVSGQCLCPAGLHGQFCERGCEPGSFGEGCGQQCDCELGVPCDPVTGHCLCPPGRTGTTCDLGCRRGFFGPGCALHCSCGGGADCDPVSGQCLCVDGYTGPTCRQGGPSQLPESPSPALGPAALQPGSHQTRAQQQPREALAQGQPPLRLGSQGPLRGPGGFGVH", "length": 1721, "header": "tr|E1BGE0-1|E1BGE0_BOVIN Isoform 1 of Multiple EGF like domains 6 OS=Bos taurus OX=9913 GN=MEGF6 PE=4 SV=3 CANONICAL=E1BGE0-1" }, "locus": { "chromosome": "16", "start_pos": 49536214, "end_pos": 49436590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027771.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027771.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027771.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027771.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616459", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "scavenger receptor activity", "id": "GO:0005044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005044", "evidence": [ { "database": "UniProtKB", "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BGE0", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1111, "end_pos": 1113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1473, "end_pos": 1475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 665, "end_pos": 667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 852, "end_pos": 854, "annotation": "n_glycosylation_sequon" }, { "start_pos": 987, "end_pos": 989, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 196, "end_pos": 231, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE0" }, { "id": "PS51041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EMI", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 197, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1111, "end_pos": 1113 }, { "start_pos": 1473, "end_pos": 1475 }, { "start_pos": 665, "end_pos": 667 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 852, "end_pos": 854 }, { "start_pos": 987, "end_pos": 989 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGE4-1", "uniprot_ac": "E1BGE4", "uniprot_id": "E1BGE4_BOVIN", "mass": { "chemical_mass": 65060.0, "monoisotopic_mass": 65060.0 }, "refseq": { "ac": "XP_002699367", "name": "solute carrier family 22 member 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699367" }, "gene_names": [ { "name": "LOC520237", "type": "recommended", "evidence": [ { "id": "E1BGE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" } ] }, { "name": "LOC520237", "type": "synonym", "evidence": [ { "id": "XP_002699367", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699367" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BGE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE4/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 22 member 10", "type": "synonym", "evidence": [ { "id": "XP_002699367", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699367" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGE4", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC520237", "url": "https://www.uniprot.org/uniprotkb/E1BGE4", "locus": {} } ], "crossref": [ { "id": "E1BGE4", "url": "https://alphafold.ebi.ac.uk/entry/E1BGE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038655", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038655", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520237", "url": "https://www.ncbi.nlm.nih.gov/gene/520237", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520237", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520237", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMIICQI", "url": "https://omabrowser.org/oma/group/MMIICQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGE4", "url": "https://www.orthodb.org/?gene=E1BGE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002699367", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699367", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGE4", "url": "https://www.uniprot.org/uniprotkb/E1BGE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGKLFSFEARIEVILTLLEDCLCPMAFEELLDEVGGLGKFQILQMALILPSLMIIVCQILLENFTAAIPRHRCWVHILDNDTVSDNDTGFLSPDVLLRISIPLDSNLKPEKCHRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVYDHSLFSSTIVTEWDLICDHQSQKPVAQSLFMAGMLVGGFIYGHLSDRFGRKLILRCCLLQLAISGTCAAFAPTFLIYCSIRFWSGCSAVVIVANNIMLIIEWTRSQSKAMILTLVACTFSMGQMMLGGLAFVFREWRTLQLVVSVPFFVFFLSSRWLVESARWLIITNKPDEGLKELKKVAHRNGMKNAEATLNMEGLRVTMQEELKTAQMKTTVFDLFRTPKLRKRICLLFFVRFGTTIPFFGIFINLQHFGSNIFLFQVIFGALTGLTRCLIPPVLNHMGRRPTQTLFMFLVGLSILVNTFVPQEMQTVRVTLASVGMGCVAASNTSISVHFVELLPTLVRARAAGIDMMASRCGAALAPLLMTLVVYLPTLPWIIYGVCPIIASLLVLLQPETRHLPLPDTIQDVENKKQFSRKVNEEDFCIKVTKF", "length": 577, "header": "tr|E1BGE4-1|E1BGE4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC520237 PE=4 SV=3 CANONICAL=E1BGE4-1" }, "isoforms": [ { "isoform_ac": "E1BGE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGE4/entry#E1BGE4-1", "sequence": { "sequence": "MKGKLFSFEARIEVILTLLEDCLCPMAFEELLDEVGGLGKFQILQMALILPSLMIIVCQILLENFTAAIPRHRCWVHILDNDTVSDNDTGFLSPDVLLRISIPLDSNLKPEKCHRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVYDHSLFSSTIVTEWDLICDHQSQKPVAQSLFMAGMLVGGFIYGHLSDRFGRKLILRCCLLQLAISGTCAAFAPTFLIYCSIRFWSGCSAVVIVANNIMLIIEWTRSQSKAMILTLVACTFSMGQMMLGGLAFVFREWRTLQLVVSVPFFVFFLSSRWLVESARWLIITNKPDEGLKELKKVAHRNGMKNAEATLNMEGLRVTMQEELKTAQMKTTVFDLFRTPKLRKRICLLFFVRFGTTIPFFGIFINLQHFGSNIFLFQVIFGALTGLTRCLIPPVLNHMGRRPTQTLFMFLVGLSILVNTFVPQEMQTVRVTLASVGMGCVAASNTSISVHFVELLPTLVRARAAGIDMMASRCGAALAPLLMTLVVYLPTLPWIIYGVCPIIASLLVLLQPETRHLPLPDTIQDVENKKQFSRKVNEEDFCIKVTKF", "length": 577, "header": "tr|E1BGE4-1|E1BGE4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC520237 PE=4 SV=3 CANONICAL=E1BGE4-1" }, "locus": { "chromosome": "29", "start_pos": 41566820, "end_pos": 41541561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004200.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004200.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004200.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004200.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520237", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520237", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3L854-1", "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein", "gene_name": "LOC100737875", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFEELLNEVGGLGKFQILQMLLAFPPLMMVVCHILLENFTAAIPGHHCWVRILDNDTDSGNDTGTLGPEVLLRISIPLDSNLKPEKCRRYLHPQWQLLHLNGTFPNVTDLDTEPCVDGWVYDQSSFSHTIVTEWDLVCDYQSQKPLVQFAFMAGMLLGGFLYGYLSDRFGRKLILRWCLLQLAISGTCAAFAPNFLVYCFLRFWSGCSAVAILSNNSMIVVEWTRAQSKAMVISVITCATGIGQIILGGLAFVFREWRTLQLVVSVPFFVFFLSTWCLVESARWLIITNKPAKGLKELKKVAHRNGLKNAEATLNMEGLRETMKEELEVAQTNTTLLDLFRTPKLRKRMCLLAFVRFANTMPFYGIFINLQHFGNNIFLFQVIFGVLSTLARSLLFIVMNHMDRRPTQMLFMFLVGISILANTFVPQDMQILRVTLGSLGIGFIAASITSYSVHSFELIPTLLRAKASGLELMVSRFGAALAPLLMTLVVYQPILPWIIYGVSPIIAGLVVFFQPETKNLPLPDTIQDVENHKNFLRKVNEKEAYIKVTKL", "length": 552 }, "evidence": [ { "id": "E1BGE4", "url": "https://omabrowser.org/oma/group/E1BGE4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BGE4", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1BGE4", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "organic anion transport", "id": "GO:0015711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015711", "evidence": [ { "database": "UniProtKB", "id": "E1BGE4", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 577, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGE4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGE4" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 121, "end_pos": 545, "start_aa": "Trp", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 474, "end_pos": 476 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 81, "end_pos": 83 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGF1-1", "uniprot_ac": "E1BGF1", "uniprot_id": "E1BGF1_BOVIN", "mass": { "chemical_mass": 46539.0, "monoisotopic_mass": 46539.0 }, "refseq": { "ac": "XP_005218483", "name": "uncharacterized protein KIAA0513 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218483" }, "gene_names": [ { "name": "KIAA0513", "type": "recommended", "evidence": [ { "id": "E1BGF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGF1" } ] }, { "name": "KIAA0513", "type": "synonym", "evidence": [ { "id": "XP_005218483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218483" } ] } ], "protein_names": [ { "name": "KIAA0513", "type": "synonym", "evidence": [ { "id": "E1BGF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGF1/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein KIAA0513 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218483" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGF1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA0513", "url": "https://www.uniprot.org/uniprotkb/E1BGF1", "locus": { "chromosome": "18", "start_pos": 11185409, "end_pos": 11129698, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020835", "url": "https://www.ensembl.org/id/ENSBTAG00000020835" } ] } } ], "crossref": [ { "id": "E1BGF1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020835", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020835", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507534", "url": "https://www.ncbi.nlm.nih.gov/gene/507534", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507534", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507534", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERDKWSH", "url": "https://omabrowser.org/oma/group/ERDKWSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHA5", "url": "https://www.orthodb.org/?gene=A0A3Q1MHA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BGF1", "url": "https://www.orthodb.org/?gene=E1BGF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13663:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13663:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218483", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218483", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHA5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGF1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGF1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAPEVPVGSLIDFGAQPSASSPLEAPPPKLQDGDSSPGEGASESETTESADSENDMGESPSHPSWGQYRRSSSNESFSSNQSADSAKDEEPLELREFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPHPLPTESKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPPARRSEEEEGRPQEKPRKTVTVCSPEEERKGEKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRGDAGEEEKKRERWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMAAE", "length": 410, "header": "tr|E1BGF1-1|E1BGF1_BOVIN Isoform 1 of KIAA0513 OS=Bos taurus OX=9913 GN=KIAA0513 PE=4 SV=3 CANONICAL=E1BGF1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1/entry#A0A3Q1MHA5-1", "sequence": { "sequence": "MEAPEVPVGSLIDFGAQPSASSPLEAPPPKLQDGDSSPGEGASESETTESADSENDMGESPSHPSWGQYRRSSSNESFSSNQSADSAKDEEPLELREFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPHPLPTESKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPPARRSEEEEGRPQEKPRKTVTVCSPEEERKGEKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRERWCHMTQEERDDSLRFNENITFGQLGAVQAAERPHRADGCRVGHRRWPETPPEDCSWLLPPLHDIGSTYAALEVAVRRIWLPILPTSLCLCLLPTCVPKCPWDYTAKTKVTVHTLEWQACDLGLRGHRRKDAGSQVGTCPSQPPAEKTGSVGR", "length": 480, "header": "tr|A0A3Q1MHA5-1|A0A3Q1MHA5_BOVIN Computationally mapped isoform of KIAA0513 OS=Bos taurus OX=9913 GN=KIAA0513 PE=4 SV=2 CANONICAL=E1BGF1-1" }, "locus": { "chromosome": "18", "start_pos": 11184405, "end_pos": 11167158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077413.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077413.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070615.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070615.2" } ] } }, { "isoform_ac": "A0AAA9SZZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1/entry#A0AAA9SZZ7-1", "sequence": { "sequence": "MEAPEVPVGSLIDFGAQPSASSPLEAPPPKLQDGDSSPGEGASESETTESADSENDMGESPSHPSWGQYRRSSSNESFSSNQSADSAKDEEPLELREFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPHPLPTESKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPPARRSEEEEGRPQEKPRKTVTVCSPEEERKGEKIYLYTHLKQQPIWERWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMAAE", "length": 374, "header": "tr|A0AAA9SZZ7-1|A0AAA9SZZ7_BOVIN Computationally mapped isoform of KIAA0513 OS=Bos taurus OX=9913 GN=KIAA0513 PE=4 SV=2 CANONICAL=E1BGF1-1" }, "locus": { "chromosome": "18", "start_pos": 11184070, "end_pos": 11167158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128313.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128313.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089705.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089705.2" } ] } }, { "isoform_ac": "A0AAA9THN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1/entry#A0AAA9THN9-1", "sequence": { "sequence": "MEAPEVPVGSLIDFGAQPSASSPLEAPPPKLQDGDSSPGEGASESETTESADSENDMGESPSHPSWGQYRRSSSNESFSSNQSADSAKDEEPLELREFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPHPLPTESKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPPARRSEEEEGRPQEKPRKTVTVCSPEEERKGEKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRERWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMAAE", "length": 400, "header": "tr|A0AAA9THN9-1|A0AAA9THN9_BOVIN Computationally mapped isoform of KIAA0513 OS=Bos taurus OX=9913 GN=KIAA0513 PE=4 SV=2 CANONICAL=E1BGF1-1" }, "locus": { "chromosome": "18", "start_pos": 11184070, "end_pos": 11167158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109411.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109411.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098037.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098037.2" } ] } }, { "isoform_ac": "E1BGF1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGF1/entry#E1BGF1-1", "sequence": { "sequence": "MEAPEVPVGSLIDFGAQPSASSPLEAPPPKLQDGDSSPGEGASESETTESADSENDMGESPSHPSWGQYRRSSSNESFSSNQSADSAKDEEPLELREFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPHPLPTESKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPPARRSEEEEGRPQEKPRKTVTVCSPEEERKGEKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRGDAGEEEKKRERWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMAAE", "length": 410, "header": "tr|E1BGF1-1|E1BGF1_BOVIN Isoform 1 of KIAA0513 OS=Bos taurus OX=9913 GN=KIAA0513 PE=4 SV=3 CANONICAL=E1BGF1-1" }, "locus": { "chromosome": "18", "start_pos": 11184070, "end_pos": 11167158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027767.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027767.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027767.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027767.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507534", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507534", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A0F9-1", "protein_name": "KIAA0513", "gene_name": "KIAA0513", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAPEVPVGSLIDFGAEPSTSSPLEAMPPKLPDGDSSPGEGASESETTESADSENDLGESPSHPAWGGYRRSSSNESFSSNQSADSAKDEEPRELREFMRHYVEKIFSGGEDLDQEEKAKFGEHCSSENGKAREWFARYVSAQRCNSKCVSEPTFYRLVQSFAVVLFECHQMDDFAPAKSLMTMCFTYYYIGKPQLLPSEAKEKPAGSIDAYLRSANSWLAEKKDIAERLLKNTSAKTENVKGFFGLETKPKGPLARRSEEEEDKPQEKPPGTVTVCSPEEERRGQKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRGDAGEEEEKRERWCHMTQEERDDSLRFDENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMAVE", "length": 410 }, "evidence": [ { "id": "E1BGF1", "url": "https://omabrowser.org/oma/group/E1BGF1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y331-1", "protein_name": "KIAA0513", "gene_name": "KIAA0513", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAPPDVPVGNLIDFSTEEPSRAPSGPSPPAVPSDNGHLGEVTAEESDATESADSENDMGESPARWGHRRSSSGESFSSNHSSGSARDEAASERRDFVRHYVEKIFTGGEDLEQEEKARFGELCSGEDGKGREWFARYVSAQRCNSKCVSEQTFYRLMQSFALVLFECHQMDDFSPAKNLMTMCFTYYYIGKTHALPLEAKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGGLETKLKGPAAKKSDEGEDKPKEKLKKMVSMQSPEEEKKGEKIYLYMHLKQQPIWHNLRFWNAAFFDAVHCERRKRSPTTRGNVGEEEEKREKWCHMTQEERDDSLRFNENITFGQLGTFIHNMLAFGLTKKLCSDFLKKQATIGNLDEEQYKLLSDHIEQMATE", "length": 410 }, "evidence": [ { "id": "E1BGF1", "url": "https://omabrowser.org/oma/group/E1BGF1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A3C2-1", "protein_name": "RIKEN cDNA 6430548M08 gene like", "gene_name": "6430548M08Rikl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAPEVPVGSLIDFGTEPPTSPPLEAAPSTLQDPDGSLGDGASESETTESADSENDMGESPSHPSWDQDRRSSSNESFSSNQSADSAPDEETLALREFMRSYVEKIFSGGEDLDQEEKAKFGEYCSGEDGKGREWFARFVSAQRCKSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYYLGKPYLPPTEPREKPAGSIDSYLKSANSWLAEKKDIAERLLKNTENMKGFFGGLETKLKGPLVRKNEEDENKPKDRQTKTVTVISPEDEQKGEKVYLYTHLRQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRGDAGEQEEKREKWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCSDFLKKQAVIGNLDEEQYKLLSDHIEQMATE", "length": 407 }, "evidence": [ { "id": "E1BGF1", "url": "https://omabrowser.org/oma/group/E1BGF1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60268-1", "protein_name": "Uncharacterized protein KIAA0513", "gene_name": "KIAA0513", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METPEVPVGSLIDFGPEAPTSSPLEAPPPVLQDGDGSLGDGASESETTESADSENDMGESPSHPSWDQDRRSSSNESFSSNQSTESTQDEETLALRDFMRGYVEKIFSGGEDLDQEEKAKFGEYCSSENGKGREWFARYVSAQRCNSKCVSEATFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHIGKPQLLPPESREKPAGSIDSYLKSANSWLAEKKDIAERLLKNTSARTENVKGFFGGLETKLKGPLARRNEEDENKPQEKRPRAVTAYSPEDEKKGEKIYLYTHLKQQPIWHTLRFWNAAFFDAVHCERTKRSPTTRGDAGEEEEKREKWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCNDFLKKQAVIGNLDEEQYKLLSDHIEQMATE", "length": 411 }, "evidence": [ { "id": "E1BGF1", "url": "https://omabrowser.org/oma/group/E1BGF1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R0A7-1", "protein_name": "Uncharacterized protein KIAA0513", "gene_name": "Kiaa0513", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAPEVPVGSLIDFETEPPTSPPLEAAPSTLQDPDGSLGDGASESETTESADSENDMGESPSHPSWDQDRRSSSNESFSSNQSADSAPDEETLALREFMRSYVEKIFSGGEDLDQEEKAKFGEYCSGEDGKGREWFARFVSAQRCKSKCVSEPTFYRLVQSFAVVLFECHQMDDFGPAKNLMTMCFTYYHLGKPQLPPTEPREKPAGSIDSYLKSANSWLAEKKDIAERLLKNTENMKGFFGGLETKLKGPLVRKNEEDENKPKDRQTKTVTMISPEDEQKGEKVYLYTHLRQQPIWHTLRFWNAAFFDAVHCERRKRSPTTRGDAGEQEEKREKWCHMTQEERDDSLRFNENITFGQLGTFTHNMLAFGLNKKLCSDFLKKQAVIGNLDEEQYKLLSDHIEQMATE", "length": 407 }, "evidence": [ { "id": "E1BGF1", "url": "https://omabrowser.org/oma/group/E1BGF1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGF1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 410, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGF1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGF1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGF1" }, { "id": "PF12335", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12335" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SBF1/SBF2", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 337, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 233, "end_pos": 235 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 75, "end_pos": 77 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGG1-1", "uniprot_ac": "E1BGG1", "uniprot_id": "E1BGG1_BOVIN", "mass": { "chemical_mass": 81534.0, "monoisotopic_mass": 81534.0 }, "refseq": {}, "gene_names": [ { "name": "RSPH4A", "type": "recommended", "evidence": [ { "id": "E1BGG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ] } ], "protein_names": [ { "name": "Radial spoke head component 4A", "type": "synonym", "evidence": [ { "id": "E1BGG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGG1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSPH4A", "url": "https://www.uniprot.org/uniprotkb/E1BGG1", "locus": { "chromosome": "9", "start_pos": 33951892, "end_pos": 33964912, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011890", "url": "https://www.ensembl.org/id/ENSBTAG00000011890" } ] } } ], "crossref": [ { "id": "E1BGG1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011890", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011890", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22963", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22963", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509632", "url": "https://www.ncbi.nlm.nih.gov/gene/509632", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BGG1", "url": "https://www.orthodb.org/?gene=E1BGG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13159", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13159", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13159:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13159:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04712", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S768", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S768-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S768-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGG1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDSIPVNQKIKHQELGETGRPWEETVTTSQAPELGLSEALELEQGPETGLQPRSSPPTMPLSGARTPDRPVDDLVGLRASFPSSAFQELPSTLSPLALARQDFMAPWQSDKTTSVIPEAETPHFGHLEQLSDKGGSTLHQTCQSKGNTFHQSQQTKYPLYELRDVSDHTSKQKELRFDIFQEDDSDSNCHLDQPESGASQVAPSMLEIAIQNTKAYLLKTSSKSGLNLYDHLSEMLTKVLDKRPENAVDIIENISQDVKMEHFSKKLDTLQNENEMLPTYEMAEKQKTLFLQGNVEGADQELEDEIAEHALPNIMESAFYFEQAGVGLGTDETYRIFLALKQLTDTHPIQKCRFWGKILGLEMNYIVAEVEFREGEDEEEVEEEDVPEERDNGDSEADEDDEDELPRPFYKAPQAIPKEESRTGANKYVYFVCNEPGRPWVKLPAVTPAQIVIARKIKKFFTGRLDTPIISYPPFPGNESNYLRAQIARISAGTHVSPLGFYHFGEEEGEEEEEIESGRDSFEENPDFEGIQVIDLVESLSNWVHHVQHILPQGRCNWFNPIQKSEEEEEEEDEEKEDEKGEEPDDTEQEVGPPLLTPISEDLEIQNTSPWTTRLSSNLIPQYAIAVLRSNLWPGAYAFSNGKKFENFYIGWGHKYSPDSYTPPVPPPVYQEYPSGPEITEMDDPTVEEEQAFRAAQEAVQEENEETEEEEDEEDDYD", "length": 719, "header": "tr|E1BGG1-1|E1BGG1_BOVIN Isoform 1 of Radial spoke head component 4A OS=Bos taurus OX=9913 GN=RSPH4A PE=4 SV=4 CANONICAL=E1BGG1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2Q1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1/entry#A0AAA9S2Q1-1", "sequence": { "sequence": "MEDSIPVNQKIKHQELGETGRPWEETVTTSQAPELGLSEALELEQGPETGLQPRSSPPTMPLSGARTPDRPVDDLVGLRASFPSSAFQELPSTLSPLALARQDFMAPWQSDKTTSVIPEAETPHFGHLEQLSDKGGSTLHQTCQSKGNTFHQSQQTKYPLYELRDVSDHTSKQKELRFDIFQEDDSDSNCHLDQPESGASQVAPSMLEIAIQNTKAYLLKTSSKSGLNLYDHLSEMLTKVLDKRPENAVDIIENISQDVKMEHFSKKLDTLQNENEMLPTYEMAEKQKTLFLQGNVEGADQELEDEIGRCNWFNPIQKSEEEEEEEDEEKEDEKGEEPDDTEQEVGPPLLTPISEDLEIQNTSPWTTRLSSNLIPQYAIAVLRSNLWPGAYAFSNGKKFENFYIGWGHKYSPDSYTPPVPPPVYQEYPSGPEITEMDDPTVEEEQAFRAAQEAVQEENEETEEEEDEEDDYD", "length": 472, "header": "tr|A0AAA9S2Q1-1|A0AAA9S2Q1_BOVIN Computationally mapped isoform of Radial spoke head component 4A OS=Bos taurus OX=9913 GN=RSPH4A PE=4 SV=1 CANONICAL=E1BGG1-1" }, "locus": { "chromosome": "9", "start_pos": 33964912, "end_pos": 33951895, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079332.1" } ] } }, { "isoform_ac": "A0AAA9S768-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1/entry#A0AAA9S768-1", "sequence": { "sequence": "MEDSIPVNQKIKHQELGETGRPWEETVTTSQAPELGLSEALELEQGPETGLQPRSSPPTMPLSGARTPDRPVDDLVGLRASFPSSAFQELPSTLSPLALARQDFMAPWQSDKTTSVIPEAETPHFGHLEQLSDKGGSTLHQTCQSKGNTFHQSQQTKYPLYELRDVSDHTSKQKELRFDIFQEDDSDSNCHLDQPESGASQVAPSMLEIAIQNTKAYLLKTSSKSGLNLYDHLSEMLTKVLDKRPENAVDIIENISQDVKMEHFSKKLDTLQNENEMLPTYEMAEKQKTLFLQGNVEGADQELEDEIAEHALPNIMESAFYFEQAGVGLGTDETYRIFLALKQLTDTHPIQKCRFWGKILGLEMNYIVAEVEFREGEDEEEVEEEDVPEERDNGDSEADEDDEDELPRPFYKAPQAIPKEESRTGANKYVYFVCNEPGRPWVKLPAVTPAQIVIARKIKKFFTGRLDTPIISYPPFPGNESNYLRAQIARISAGTHVSPLGFYHFGEEEGEEEEEIESGRDSFEENPDFEGIQVIDLVESLSNWVHHVQHILPQRFRIHRLGQHGYPQISFLNMRLQSLDPTFGLEHMPFPMAKSLKIST", "length": 600, "header": "tr|A0AAA9S768-1|A0AAA9S768_BOVIN Computationally mapped isoform of Radial spoke head component 4A OS=Bos taurus OX=9913 GN=RSPH4A PE=4 SV=1 CANONICAL=E1BGG1-1" }, "locus": { "chromosome": "9", "start_pos": 33964912, "end_pos": 33952110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103242.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103242.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079153.1" } ] } }, { "isoform_ac": "E1BGG1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1/entry#E1BGG1-1", "sequence": { "sequence": "MEDSIPVNQKIKHQELGETGRPWEETVTTSQAPELGLSEALELEQGPETGLQPRSSPPTMPLSGARTPDRPVDDLVGLRASFPSSAFQELPSTLSPLALARQDFMAPWQSDKTTSVIPEAETPHFGHLEQLSDKGGSTLHQTCQSKGNTFHQSQQTKYPLYELRDVSDHTSKQKELRFDIFQEDDSDSNCHLDQPESGASQVAPSMLEIAIQNTKAYLLKTSSKSGLNLYDHLSEMLTKVLDKRPENAVDIIENISQDVKMEHFSKKLDTLQNENEMLPTYEMAEKQKTLFLQGNVEGADQELEDEIAEHALPNIMESAFYFEQAGVGLGTDETYRIFLALKQLTDTHPIQKCRFWGKILGLEMNYIVAEVEFREGEDEEEVEEEDVPEERDNGDSEADEDDEDELPRPFYKAPQAIPKEESRTGANKYVYFVCNEPGRPWVKLPAVTPAQIVIARKIKKFFTGRLDTPIISYPPFPGNESNYLRAQIARISAGTHVSPLGFYHFGEEEGEEEEEIESGRDSFEENPDFEGIQVIDLVESLSNWVHHVQHILPQGRCNWFNPIQKSEEEEEEEDEEKEDEKGEEPDDTEQEVGPPLLTPISEDLEIQNTSPWTTRLSSNLIPQYAIAVLRSNLWPGAYAFSNGKKFENFYIGWGHKYSPDSYTPPVPPPVYQEYPSGPEITEMDDPTVEEEQAFRAAQEAVQEENEETEEEEDEEDDYD", "length": 719, "header": "tr|E1BGG1-1|E1BGG1_BOVIN Isoform 1 of Radial spoke head component 4A OS=Bos taurus OX=9913 GN=RSPH4A PE=4 SV=4 CANONICAL=E1BGG1-1" }, "locus": { "chromosome": "9", "start_pos": 33964912, "end_pos": 33951895, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015775.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015775.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015775.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015775.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 448, "start_aa": "Thr", "end_pos": 448, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr448", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "radial spoke", "id": "GO:0001534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001534", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cilium movement involved in cell motility", "id": "GO:0060294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060294", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1BGG1", "url": "https://www.uniprot.org/uniprotkb/E1BGG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 608, "end_pos": 610, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGG1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 719, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGG1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGG1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 448 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 608, "end_pos": 610 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGG3-1", "uniprot_ac": "E1BGG3", "uniprot_id": "E1BGG3_BOVIN", "mass": { "chemical_mass": 35215.0, "monoisotopic_mass": 35215.0 }, "refseq": { "ac": "XP_005204959", "name": "coiled-coil domain-containing protein 24 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204959" }, "gene_names": [ { "name": "CCDC24", "type": "recommended", "evidence": [ { "id": "E1BGG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGG3" } ] }, { "name": "CCDC24", "type": "synonym", "evidence": [ { "id": "XP_005204959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204959" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 24", "type": "synonym", "evidence": [ { "id": "E1BGG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGG3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 24 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005204959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204959" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGG3", "url": "https://www.uniprot.org/uniprotkb/E1BGG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC24", "url": "https://www.uniprot.org/uniprotkb/E1BGG3", "locus": { "chromosome": "3", "start_pos": 102060314, "end_pos": 102068920, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011888", "url": "https://www.ensembl.org/id/ENSBTAG00000011888" } ] } } ], "crossref": [ { "id": "E1BGG3", "url": "https://alphafold.ebi.ac.uk/entry/E1BGG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011888", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011888", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000049520", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049520", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516188", "url": "https://www.ncbi.nlm.nih.gov/gene/516188", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PSSCHWD", "url": "https://omabrowser.org/oma/group/PSSCHWD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGG3", "url": "https://www.orthodb.org/?gene=E1BGG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28601:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28601:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3N5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBG8", "url": "https://www.uniprot.org/uniprotkb/E1BBG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBG8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGG3", "url": "https://www.uniprot.org/uniprotkb/E1BGG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGG3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGDSPSLWELVEEHVPLPERPEVKRILGETTVDLSLELRAEVGRKKVVMLRSLLQEARSSQAPGSRPTSDLSSLLAPPPLVRDLVRQELRQLLQGLRRKAICEGRDQTQAWVQYSPRVLRFALEEPRRDLPEQEMFQMRAGDPSCYRDLSVIKDQLNMSHIDQVAGHLRALLEEECRALEREIPILQRCLEEEYIGAARPSKPSLEPTLAELKEQKAAMQQELQSPLRPSCVSSSHRPQPLGSSSQGPGPLSCLHGAAGVWARPLQCCLPAPPLEHCPKPRSLASTCRWGRKIQCSPRKRPASTPMSSAAPQAPT", "length": 316, "header": "tr|E1BGG3-1|E1BGG3_BOVIN Isoform 1 of Coiled-coil domain containing 24 OS=Bos taurus OX=9913 GN=CCDC24 PE=4 SV=4 CANONICAL=E1BGG3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3N5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG3/entry#A0AAA9S3N5-1", "sequence": { "sequence": "MPGDSPSLWELVEEHVPLPERPEVKRILGETTVDLSLELRAEVVMLRSLLQEARSSQAPGSRPTSDLSSLLAPPPLVRDLVRQELRQLLQGLRRKAICEGRDQTQAWVQYSPRVLRFALEEPRRDLPEQEMFQMRAGDPSSCYRDLSVIKDQLNMSHIDQVAGHLRALLEEECRALEREIPILQRCLEEEYIGAARPSKPSLEPTLAELKEQKAAMQQELQSPLRPSCVSSSHRIHSFPTSSTMAVTNVSRRQNCRIRPSEQGPTLGPASSRPQPQARVPHLVPECPAPAR", "length": 291, "header": "tr|A0AAA9S3N5-1|A0AAA9S3N5_BOVIN Computationally mapped isoform of Coiled-coil domain containing 24 OS=Bos taurus OX=9913 GN=CCDC24 PE=4 SV=1 CANONICAL=E1BGG3-1" }, "locus": { "chromosome": "3", "start_pos": 102068721, "end_pos": 102060327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112379.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112379.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076712.1" } ] } }, { "isoform_ac": "E1BBG8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG3/entry#E1BBG8-1", "sequence": { "sequence": "FLPHSPLYLSSLNKEHVPLPERPEVKRILGETTVDLSLERAEVVMLQSLLQEARSIQASGSRPTSDLSSLLAPPPLLRDLVCQELQQLLQGLRLKAICEGRDQTHAWVQYSPSVLCFALEEPRRDLPEQEMFQMRAGEPSSCHWDLSVIKDQLNVSHTDQAAEECRALEREIPILQRCLEDEYSGAPRPSEASLEPTLAELKQQKAAMQQELQAPLRPSYVSPSHRPQPLESSSQGTGLLPCLHGATRVWARLLQCFLPAPRLERCPKLRSLATTCHWGRKIQCLPGKRPASTLMSSVAPQAPT", "length": 304, "header": "tr|E1BBG8-1|E1BBG8_BOVIN Computationally mapped isoform of Coiled-coil domain containing 24 OS=Bos taurus OX=9913 GN=CCDC24 PE=4 SV=3 CANONICAL=E1BGG3-1" }, "locus": { "chromosome": "13", "start_pos": 37756350, "end_pos": 37752435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053017.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053017.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049570.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049570.3" } ] } }, { "isoform_ac": "E1BGG3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGG3/entry#E1BGG3-1", "sequence": { "sequence": "MPGDSPSLWELVEEHVPLPERPEVKRILGETTVDLSLELRAEVGRKKVVMLRSLLQEARSSQAPGSRPTSDLSSLLAPPPLVRDLVRQELRQLLQGLRRKAICEGRDQTQAWVQYSPRVLRFALEEPRRDLPEQEMFQMRAGDPSCYRDLSVIKDQLNMSHIDQVAGHLRALLEEECRALEREIPILQRCLEEEYIGAARPSKPSLEPTLAELKEQKAAMQQELQSPLRPSCVSSSHRPQPLGSSSQGPGPLSCLHGAAGVWARPLQCCLPAPPLEHCPKPRSLASTCRWGRKIQCSPRKRPASTPMSSAAPQAPT", "length": 316, "header": "tr|E1BGG3-1|E1BGG3_BOVIN Isoform 1 of Coiled-coil domain containing 24 OS=Bos taurus OX=9913 GN=CCDC24 PE=4 SV=4 CANONICAL=E1BGG3-1" }, "locus": { "chromosome": "3", "start_pos": 102068721, "end_pos": 102065438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015772.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015772.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015772.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015772.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGG3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGG3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGG3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGH4-1", "uniprot_ac": "E1BGH4", "uniprot_id": "E1BGH4_BOVIN", "mass": { "chemical_mass": 18802.0, "monoisotopic_mass": 18802.0 }, "refseq": { "ac": "XP_002689678", "name": "transmembrane protein 252", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689678" }, "gene_names": [ { "name": "TMEM252", "type": "recommended", "evidence": [ { "id": "E1BGH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGH4" } ] }, { "name": "TMEM252", "type": "synonym", "evidence": [ { "id": "XP_002689678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689678" } ] } ], "protein_names": [ { "name": "Transmembrane protein 252", "type": "synonym", "evidence": [ { "id": "E1BGH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGH4/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 252", "type": "synonym", "evidence": [ { "id": "XP_002689678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689678" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGH4", "url": "https://www.uniprot.org/uniprotkb/E1BGH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM252", "url": "https://www.uniprot.org/uniprotkb/E1BGH4", "locus": { "chromosome": "8", "start_pos": 44618781, "end_pos": 44622341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011874", "url": "https://www.ensembl.org/id/ENSBTAG00000011874" } ] } } ], "crossref": [ { "id": "E1BGH4", "url": "https://alphafold.ebi.ac.uk/entry/E1BGH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011874", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011874", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614257", "url": "https://www.ncbi.nlm.nih.gov/gene/614257", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614257", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614257", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LYTEMGL", "url": "https://omabrowser.org/oma/group/LYTEMGL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGH4", "url": "https://www.orthodb.org/?gene=E1BGH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35682:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35682:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689678", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGH4", "url": "https://www.uniprot.org/uniprotkb/E1BGH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQNRTCLVLCVFALLTGFLMICLGAFFISSASLFNCQGNLTLAYLLLPLGFVILLGGIFWSTYHQASESKGVFNRVLGQYHAQGALPLATVDRPGFYPPAYEESPAADKRACHTEQETSDAPPPPYTEMGLEFQDEDGAHPEAPPPYDESVAERVAAARPWQDAQRRSQEC", "length": 171, "header": "tr|E1BGH4-1|E1BGH4_BOVIN Isoform 1 of Transmembrane protein 252 OS=Bos taurus OX=9913 GN=TMEM252 PE=4 SV=1 CANONICAL=E1BGH4-1" }, "isoforms": [ { "isoform_ac": "E1BGH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGH4/entry#E1BGH4-1", "sequence": { "sequence": "MQNRTCLVLCVFALLTGFLMICLGAFFISSASLFNCQGNLTLAYLLLPLGFVILLGGIFWSTYHQASESKGVFNRVLGQYHAQGALPLATVDRPGFYPPAYEESPAADKRACHTEQETSDAPPPPYTEMGLEFQDEDGAHPEAPPPYDESVAERVAAARPWQDAQRRSQEC", "length": 171, "header": "tr|E1BGH4-1|E1BGH4_BOVIN Isoform 1 of Transmembrane protein 252 OS=Bos taurus OX=9913 GN=TMEM252 PE=4 SV=1 CANONICAL=E1BGH4-1" }, "locus": { "chromosome": "8", "start_pos": 44622341, "end_pos": 44618784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015757.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015757.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015757.3", "url": "https://www.ensembl.org/id/ENSBTAP00000015757.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614257", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614257", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IFP8-1", "protein_name": "Transmembrane protein 252", "gene_name": "Tmem252", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQNRTGLIFCALSLLTGFLMICLGGFFISNSIFHSQRNLVIAYVLLPMGFVILLSGIFWATYRQANENKEMFNHVLRQHLASQDLLLTTIDRPNFYPPAYEESLDAEKQTCPAGGGFLEFPPPPYTATSLELEDENEPQPEAPPSYQESTAGTVVTVKAQDAVGPSTVLKAGPALQHSGLPSC", "length": 183 }, "evidence": [ { "id": "E1BGH4", "url": "https://omabrowser.org/oma/group/E1BGH4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6AXS2-1", "protein_name": "Transmembrane protein 252", "gene_name": "Tmem252", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQNRTGLVLCALSLLTGFLMICLGGFFISSSSSHSHRNLVVAYVLLPLGFVILLSGIFWGTYRQANDNKEMFNHVLRQHLAFQDLPLATVDRPDFYPPAYEESLDVEKQACSAGRGLLGFPPPLYTETSLEPQDKDKNDPQPEAPPPYPENIAVAAATVKTQDAEEPSTVLKAGAVLQLSELASC", "length": 185 }, "evidence": [ { "id": "E1BGH4", "url": "https://omabrowser.org/oma/group/E1BGH4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C353-1", "protein_name": "Transmembrane protein 252", "gene_name": "Tmem252", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQNRTGLILCALSLLTGFLMICLGGFFISNSIFHSQRNLVVAYVLLPMGFVILLSGIFWGTYRQANENKEMFNHVLRQHLAFQDLPLATVDRPDFYPPAYEESLDVEKQACPAGRELLGFPPPLYTETNLEFEHLEDPQPEAPPPYQEIIADAGAPAKAQDAEEPSRVLKAGTALQLTELTGR", "length": 183 }, "evidence": [ { "id": "E1BGH4", "url": "https://omabrowser.org/oma/group/E1BGH4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N6L7-1", "protein_name": "Transmembrane protein 252", "gene_name": "TMEM252", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQNRTGLILCALALLMGFLMVCLGAFFISWGSIFDCQGSLIAAYLLLPLGFVILLSGIFWSNYRQVTESKGVLRHMLRQHLAHGALPVATVDRPDFYPPAYEESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIAGLVVTAISEDAQRRGQEC", "length": 170 }, "evidence": [ { "id": "E1BGH4", "url": "https://omabrowser.org/oma/group/E1BGH4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 171, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGH4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 39, "end_pos": 41 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGK0-1", "uniprot_ac": "E1BGK0", "uniprot_id": "E1BGK0_BOVIN", "mass": { "chemical_mass": 37208.0, "monoisotopic_mass": 37208.0 }, "refseq": {}, "gene_names": [ { "name": "TIMD4", "type": "recommended", "evidence": [ { "id": "E1BGK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ] } ], "protein_names": [ { "name": "T cell immunoglobulin and mucin domain containing 4", "type": "synonym", "evidence": [ { "id": "E1BGK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGK0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMD4", "url": "https://www.uniprot.org/uniprotkb/E1BGK0", "locus": { "chromosome": "7", "start_pos": 68286089, "end_pos": 68314227, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013185", "url": "https://www.ensembl.org/id/ENSBTAG00000013185" } ] } } ], "crossref": [ { "id": "E1BGK0", "url": "https://alphafold.ebi.ac.uk/entry/E1BGK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013185", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013185", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HTDGTKV", "url": "https://omabrowser.org/oma/group/HTDGTKV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGK0", "url": "https://www.orthodb.org/?gene=E1BGK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46608", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46608", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46608:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46608:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGK0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKGPLILWLVIELGRLCLTPAASQTVVRAFLGQPVTLPCTYSSWSPNSNSMCWGRGQCPKSKCNDELLYTDGTKVVSSKSPKYQLRGIIQRGDVSLTIMDTNEGDQNVYCCRIEVPGWFNDVKRNIRLDLRRAPTTTPSTTTRRPTTTTTTTVATTTAMTTATAMLPTTVVTTSDLTSTPPLQMRTTAALTTTASMCPLTTLSSLLEEDTILLTLEPSTEGPTLTAELEPALLPRTSQRSVEETSHRSTALLTSKTPETSFLVQNEVEPEQIRMTSNYDLLIIIAPSLGFVLLALLLAFFLRGKFVKANCFQKHTRLDNVGEGKDVLSGTEDEDGLFTL", "length": 340, "header": "tr|E1BGK0-1|E1BGK0_BOVIN Isoform 1 of T cell immunoglobulin and mucin domain containing 4 OS=Bos taurus OX=9913 GN=TIMD4 PE=3 SV=1 CANONICAL=E1BGK0-1" }, "isoforms": [ { "isoform_ac": "E1BGK0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK0/entry#E1BGK0-1", "sequence": { "sequence": "MSKGPLILWLVIELGRLCLTPAASQTVVRAFLGQPVTLPCTYSSWSPNSNSMCWGRGQCPKSKCNDELLYTDGTKVVSSKSPKYQLRGIIQRGDVSLTIMDTNEGDQNVYCCRIEVPGWFNDVKRNIRLDLRRAPTTTPSTTTRRPTTTTTTTVATTTAMTTATAMLPTTVVTTSDLTSTPPLQMRTTAALTTTASMCPLTTLSSLLEEDTILLTLEPSTEGPTLTAELEPALLPRTSQRSVEETSHRSTALLTSKTPETSFLVQNEVEPEQIRMTSNYDLLIIIAPSLGFVLLALLLAFFLRGKFVKANCFQKHTRLDNVGEGKDVLSGTEDEDGLFTL", "length": 340, "header": "tr|E1BGK0-1|E1BGK0_BOVIN Isoform 1 of T cell immunoglobulin and mucin domain containing 4 OS=Bos taurus OX=9913 GN=TIMD4 PE=3 SV=1 CANONICAL=E1BGK0-1" }, "locus": { "chromosome": "7", "start_pos": 68314208, "end_pos": 68286168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017547.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017547.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017547.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017547.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZXT7-1", "protein_name": "T-cell immunoglobulin and mucin domain containing 4", "gene_name": "Timd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFDRHTDPVKMSKGLLLLWLVMELWLLCLTPAASEDTIIGFLGQSVTLPCQYSSWSQSRNSMCWGRGSCPGSKCNGELLRTDGTRTISRKSGKYTLWGSIRLGDVSLTISNTNQDDSGVYCCRIEVPGWFNDVKKTVRLELRRATTTKRPTTTTRLTTRPTTQPTTRPTTTPYLTTTPEPLPTTVMTTPDPTTTAQPQTLATTAVGTAVTMYPSTMPGSFSQKTTSFSTTEIFTKGSAITAESETLSAFNNSQRSGMTISTDTALVRPTGSKAWILSSTSQLMTQKTTLTATTRRESSKKTGELYKIEDRQTNILIIACCVGFVLMVLLFLAFLLRGKVAEANCLRRHRRPDNTEDTPLRGNRDCEMDQLENGTCCQT", "length": 379 }, "evidence": [ { "id": "E1BGK0", "url": "https://omabrowser.org/oma/group/E1BGK0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6U7R4-1", "protein_name": "T-cell immunoglobulin and mucin domain-containing protein 4", "gene_name": "Timd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNTEDSDSVLNDMSHGRDDEDGIFTL", "length": 343 }, "evidence": [ { "id": "E1BGK0", "url": "https://omabrowser.org/oma/group/E1BGK0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96H15-1", "protein_name": "T-cell immunoglobulin and mucin domain-containing protein 4", "gene_name": "TIMD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGREDEDGLFTL", "length": 378 }, "evidence": [ { "id": "E1BGK0", "url": "https://omabrowser.org/oma/group/E1BGK0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic cell clearance", "id": "GO:0043277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043277", "evidence": [ { "database": "UniProtKB", "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ], "pmid": "" }, { "name": "cytoskeletal rearrangement involved in phagocytosis, engulfment", "id": "GO:0060097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060097", "evidence": [ { "database": "UniProtKB", "id": "E1BGK0", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGK0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 340, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGK0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGK0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGK0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 115, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGK2-1", "uniprot_ac": "E1BGK2", "uniprot_id": "E1BGK2_BOVIN", "mass": { "chemical_mass": 54190.0, "monoisotopic_mass": 54190.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC74A", "type": "recommended", "evidence": [ { "id": "E1BGK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGK2" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 74A", "type": "synonym", "evidence": [ { "id": "E1BGK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGK2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGK2", "url": "https://www.uniprot.org/uniprotkb/E1BGK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC74A", "url": "https://www.uniprot.org/uniprotkb/E1BGK2", "locus": { "chromosome": "10", "start_pos": 88110924, "end_pos": 88080219, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013181", "url": "https://www.ensembl.org/id/ENSBTAG00000013181" } ] } } ], "crossref": [ { "id": "E1BGK2", "url": "https://alphafold.ebi.ac.uk/entry/E1BGK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013181", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013181", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528053", "url": "https://www.ncbi.nlm.nih.gov/gene/528053", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528053", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528053", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24114:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24114:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SE26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGK2", "url": "https://www.uniprot.org/uniprotkb/E1BGK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGK2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RHIPPNPTLPRACWDGTITTIPPKICLDESDSVSALQSSNETLYCEAEAPVAVEKEKPARESSETDLEIEDTEKFFTTGQKELYLEACKLVGVVPVSYFIRNMEESYINLNHHGLGPNGTKAIAIALVSNTTVLTLELADNCITEEGILSLVEMLQENYYLQEMNVSDNDLGLEGARILSEFLQNNTSSLFSLQLSGNNFKEESAELFCQALSNNYRIKSLDLSHNKFCDKAGEYLGQMLAINVGLQSLDLSWNHLYIRGVVALCNGLRSNVSLKKLDLSMNSFGNEGAAALGEVLRLNSYLTYLDLSSNNITNDGLSKISRALELNESLKVLKLFLNPISMDGAVLLILSIKRNPKSRMEDIDISNVLVSEQFVKILDGVCAIHPQLDVIYKSVQAPSAKKTLFTWTNPVKLIQSYADQNKISVLDFFRSLNPSGEMMMPVGEFRKAMIQQNKVPINRYQVRELIKKLGEKTGMVDFSFLKMTRS", "length": 486, "header": "tr|E1BGK2-1|E1BGK2_BOVIN Isoform 1 of Leucine rich repeat containing 74A OS=Bos taurus OX=9913 GN=LRRC74A PE=1 SV=3 CANONICAL=E1BGK2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE26-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK2/entry#A0AAA9SE26-1", "sequence": { "sequence": "MDNDEPLEPETKDESDSVSALQSSNETLYCEAEAPVAVEKEKPARESSETDLEIEDTEKFFTTGQKELYLEACKLVGVVPVSYFIRNMEESYINLNHHGLGPNGTKAIAIALVNNYRIKSLDLSHNKFCDKAGEYLGQMLAINVGLQSLDLSWNHLYIRGVVALCNGLRSNVSLKKLDLSMNSFGNEGAAALGEVLRLNSYLTYLDLSSNNITNDGLSKISRALELNESLKVLKLFLNPISMDGAVLLILSIKRNPKSRMEDIDISNVLVSEQFVKILDGVCAIHPQLDVIYKSVQAPSAKKTLFTWTNPVKLIQSYADQNKISVLDFFRSLNPSGEMMMPVGEFRKAMIQQNKVPINRYQVRELIKKLGEKTGMVDFSFLKMTRS", "length": 386, "header": "tr|A0AAA9SE26-1|A0AAA9SE26_BOVIN Computationally mapped isoform of Leucine rich repeat containing 74A OS=Bos taurus OX=9913 GN=LRRC74A PE=4 SV=1 CANONICAL=E1BGK2-1" }, "locus": { "chromosome": "10", "start_pos": 88110921, "end_pos": 88080417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099943.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099943.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084388.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084388.1" } ] } }, { "isoform_ac": "A0AAA9SH76-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK2/entry#A0AAA9SH76-1", "sequence": { "sequence": "MDNDEPLEPETKDESDSVSALQSSNETLYCEAEAPVAVEKEKPARESSETDLEIEDTEKFFTTGQKELYLEACKLVGVVPVSYFIRNMEESYINLNHHGLGPNGTKAIAIALVSNTTVLTLELADNCITEEGILSLVEMLQENYYLQEMNVSDNDLGLEGARILSEFLQNNTSSLFSLQLSGNNFKEESAELFCQALSNNYRIKSLDLSHNKFCDKAGEYLGQMLAINVGLQSLDLSWNHLYIRGVVALCNGLRSNVSLKKLDLSMNSFGNEGAAALGEVLRLNSYLTYLDLSSNNITNDGLSKISRALELNESLKVLKLFLNPISMDGAVLLILSIKRNPKSRMEDIDISNVLVSEQFVKILDGVCAIHPQLDVIYKSVQAPSAKKTLFTWTNPVKLIQSYADQNKISVLDFFRSLNPSGEMMMPVGEFRKAMIQQNKVPINRYQVRELIKKLGEKTGMVDFSFLKMTRS", "length": 471, "header": "tr|A0AAA9SH76-1|A0AAA9SH76_BOVIN Computationally mapped isoform of Leucine rich repeat containing 74A OS=Bos taurus OX=9913 GN=LRRC74A PE=4 SV=1 CANONICAL=E1BGK2-1" }, "locus": { "chromosome": "10", "start_pos": 88110921, "end_pos": 88080417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106069.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106069.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083267.1" } ] } }, { "isoform_ac": "A0AAA9T3X4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK2/entry#A0AAA9T3X4-1", "sequence": { "sequence": "MDNDEPLEPETKDESDSVSALQSSNETLYCEAEAPVAVEKEKPARESSETDLEIEDTEKFFTTGQKELYLEACKLVGVVPVSYFIRNMEESYINLNHHGLGPNGTKAIAIALVSNTTVLTLELADNCITEEGILSLVEMLQENYYLQEMNVSDNDLGLEGARILSEFLQNNTSSLFSLQLSAINVGLQSLDLSWNHLYIRGVVALCNGLRSNVSLKKLDLSMNSFGNEGAAALGEVLRLNSYLTYLDLSSNNITNDGLSKISRALELNESLKVLKLFLNPISMDGAVLLILSIKRNPKSRMEDIDISNVLVSEQFVKILDGVCAIHPQLDVIYKSVQAPSAKKTLFTWTNPVKLIQSYADQNKISVLDFFRSLNPSGEMMMPVGEFRKAMIQQNKVPINRYQVRELIKKLGEKTGMVDFSFLKMTRS", "length": 427, "header": "tr|A0AAA9T3X4-1|A0AAA9T3X4_BOVIN Computationally mapped isoform of Leucine rich repeat containing 74A OS=Bos taurus OX=9913 GN=LRRC74A PE=4 SV=1 CANONICAL=E1BGK2-1" }, "locus": { "chromosome": "10", "start_pos": 88110921, "end_pos": 88080417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104169.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104169.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091196.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091196.1" } ] } }, { "isoform_ac": "E1BGK2-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK2/entry#E1BGK2-1", "sequence": { "sequence": "RHIPPNPTLPRACWDGTITTIPPKICLDESDSVSALQSSNETLYCEAEAPVAVEKEKPARESSETDLEIEDTEKFFTTGQKELYLEACKLVGVVPVSYFIRNMEESYINLNHHGLGPNGTKAIAIALVSNTTVLTLELADNCITEEGILSLVEMLQENYYLQEMNVSDNDLGLEGARILSEFLQNNTSSLFSLQLSGNNFKEESAELFCQALSNNYRIKSLDLSHNKFCDKAGEYLGQMLAINVGLQSLDLSWNHLYIRGVVALCNGLRSNVSLKKLDLSMNSFGNEGAAALGEVLRLNSYLTYLDLSSNNITNDGLSKISRALELNESLKVLKLFLNPISMDGAVLLILSIKRNPKSRMEDIDISNVLVSEQFVKILDGVCAIHPQLDVIYKSVQAPSAKKTLFTWTNPVKLIQSYADQNKISVLDFFRSLNPSGEMMMPVGEFRKAMIQQNKVPINRYQVRELIKKLGEKTGMVDFSFLKMTRS", "length": 486, "header": "tr|E1BGK2-1|E1BGK2_BOVIN Isoform 1 of Leucine rich repeat containing 74A OS=Bos taurus OX=9913 GN=LRRC74A PE=1 SV=3 CANONICAL=E1BGK2-1" }, "locus": { "chromosome": "10", "start_pos": 88110921, "end_pos": 88080219, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017544.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017544.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017544.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017544.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1BGK2", "url": "https://www.uniprot.org/uniprotkb/E1BGK2" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:528053", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528053", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 486, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGK2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 271, "end_pos": 273 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BGM4-1", "uniprot_ac": "E1BGM4", "uniprot_id": "E1BGM4_BOVIN", "mass": { "chemical_mass": 35644.0, "monoisotopic_mass": 35644.0 }, "refseq": {}, "gene_names": [ { "name": "OR2T26", "type": "recommended", "evidence": [ { "id": "E1BGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 2 subfamily T member 26", "type": "synonym", "evidence": [ { "id": "E1BGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2T26", "url": "https://www.uniprot.org/uniprotkb/E1BGM4", "locus": { "chromosome": "7", "start_pos": 40196749, "end_pos": 40198216, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024713", "url": "https://www.ensembl.org/id/ENSBTAG00000024713" } ] } } ], "crossref": [ { "id": "E1BGM4", "url": "https://alphafold.ebi.ac.uk/entry/E1BGM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024713", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024713", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IRTMAFLGNQTLISHFILLGLFTHSPLHLLLFSIIMAMFLVALSGNGLMILLINTDSRLHSPMYFFLSWLSLMDLMLISTIVPRMAIDYLLGHGSISFTGCGLQILFFLTLLGDECFLLAFMAYDRYVAISNPLRYSVVMSRHVCWLMVAGSWLFGLVDGLIQAVFTLRFPYCGSQEIDHFFCEVPAVLKLACADTSLYETMIYVCCVLMLLLPFSVISASYLRILITVLHMRSAEGRQKAFATCSSHMAAVSLFYGAAMITYMRPQAYHSSKQDKAVSAFYTMITPMLNPLIYSLRNKEVAGALKKLLGRCSCGVGQN", "length": 319, "header": "tr|E1BGM4-1|E1BGM4_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily T member 26 OS=Bos taurus OX=9913 GN=OR2T26 PE=3 SV=4 CANONICAL=E1BGM4-1" }, "isoforms": [ { "isoform_ac": "E1BGM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM4/entry#E1BGM4-1", "sequence": { "sequence": "IRTMAFLGNQTLISHFILLGLFTHSPLHLLLFSIIMAMFLVALSGNGLMILLINTDSRLHSPMYFFLSWLSLMDLMLISTIVPRMAIDYLLGHGSISFTGCGLQILFFLTLLGDECFLLAFMAYDRYVAISNPLRYSVVMSRHVCWLMVAGSWLFGLVDGLIQAVFTLRFPYCGSQEIDHFFCEVPAVLKLACADTSLYETMIYVCCVLMLLLPFSVISASYLRILITVLHMRSAEGRQKAFATCSSHMAAVSLFYGAAMITYMRPQAYHSSKQDKAVSAFYTMITPMLNPLIYSLRNKEVAGALKKLLGRCSCGVGQN", "length": 319, "header": "tr|E1BGM4-1|E1BGM4_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily T member 26 OS=Bos taurus OX=9913 GN=OR2T26 PE=3 SV=4 CANONICAL=E1BGM4-1" }, "locus": { "chromosome": "7", "start_pos": 40198216, "end_pos": 40196752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025129.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025129.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025129.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025129.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BGM4", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGM4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGM5-1", "uniprot_ac": "E1BGM5", "uniprot_id": "E1BGM5_BOVIN", "mass": { "chemical_mass": 126567.0, "monoisotopic_mass": 126567.0 }, "refseq": {}, "gene_names": [ { "name": "OTOA", "type": "recommended", "evidence": [ { "id": "E1BGM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" } ] } ], "protein_names": [ { "name": "Otoancorin", "type": "synonym", "evidence": [ { "id": "E1BGM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGM5", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OTOA", "url": "https://www.uniprot.org/uniprotkb/E1BGM5", "locus": { "chromosome": "25", "start_pos": 20236144, "end_pos": 20165984, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018870", "url": "https://www.ensembl.org/id/ENSBTAG00000018870" } ] } } ], "crossref": [ { "id": "E1BGM5", "url": "https://alphafold.ebi.ac.uk/entry/E1BGM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018870", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018870", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026664", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026664", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059515", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059515", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BGM5", "url": "https://www.orthodb.org/?gene=E1BGM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23412:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23412:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28491", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28491", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SB25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGM5", "url": "https://www.uniprot.org/uniprotkb/E1BGM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQEPWRCSLWLFLFLSHGVASYSVPDSQDLHPLLQKMAEEIIDGSYLNALLDLIQFQSSQVWTSDLSHRVLAYLNSRNVAFTIPSLKAAMENLLEQRLYQPQKLLEDLRGTDAQQFHTAMKYLLEDKKDRLELDDIIIDLGEVRKQALQSPGVNRSLFLITLERCFQVLNPLDCVEILGRVLRGSSGRFLQPDITEMLPRDLREDAFKNLSALFKDLYDQTSAHAQRAVYCWMTGVLKTSSNVTDDSFSWVSAENLWILGRYMVHLPFEEIMRISPMEIGLFISYDNATKQLDTVYDVTPELAQAFLERISSSNFDMRNTSTIHRLGLLVCFYDDLELLDAAVAQVLLHQMIKCSHLRGFQAGVQKLKAELLEIATENQTLNETLGSLSDAVVGLTHSQLESLSPEAVHSAISTLNQVSGWARSQVIILSAKYLAHQKVLSFYNISQMGVLLAGVGTQAFHTMDRRDLMQLLRSATSLHVSDLSPAQQHAVLSKVMEAGDTASGIVKIQGALFKEVSLFDLWREPGFNSTVLKEKEIRRSQALFLFELLSKTTRRPEELLSAGQLLKGVTCPHIDAMSADSFLAHFQYFENNFSLLSPYQVNCLAWKYWEVSRSSMPPFLLAALPARYLASIPASQCVPFLISLGKSQLDSLVLDSHKKNSILKKVQQCLSHTIADEYTVDILGNLLCHLPAAVIRRGLSPRAWATALRGLRDCLDLSPQQKAALRLRLLEQHGLPQNWTAETAKDLESFLVIFSGDELSSVATKFPDILQQTASKMAGTLPPKEFLQAVFESVRNSSAEKPSRDPSPGCHGIMAPSSNDIIKLAEANACWAPEDLLCLEEDTFLRSVELLGAVRSFSLAQLRKLKEKAVQVWDMPSSWREYHIVSLGRIALALNESELEQLDLSSIDTVASLSQQTEWTPGQAKSILQGFLEDSGYRVQDLKSFHLVGLGAALCAMNITEISLIKILEFRVVVARIGTLLCSTQVLAEFKRKAEVVFGEPTEWSSFVLQELGTIAAGLTKEELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTPAQRRQLSMLQLQSLQRAIDGAKARSWLDAPPSASPARTPSSLSPPGVLQGLGLGYLLLVLMPKLVW", "length": 1136, "header": "tr|E1BGM5-1|E1BGM5_BOVIN Isoform 1 of Otoancorin OS=Bos taurus OX=9913 GN=OTOA PE=4 SV=4 CANONICAL=E1BGM5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB25-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM5/entry#A0AAA9SB25-1", "sequence": { "sequence": "MENLLEQRLYQPQKLLEDLRGTDAQQFHTAMKYLLEDKKDRLELDDIIIDLGEVRKQALQSPGVNRSLFLITLERCFQVLNPLDCVEILGRVLRGSSGRFLQPDITEMLPRDLREDAFKNLSALFKDLYDQTSAHAQRAVYCWMTGVLKTSSNVTDDSFSWVSAENLWILGRYMVHLPFEEIMRISPMEIGLFISYDNATKQLDTVYDVTPELAQAFLERISSSNFDMRNTSTIHRLGLLVCFYDDLELLDAAVAQVLLHQMIKCSHLRGFQAGVQKLKAELLEIATENQTLNETLGSLSDAVVGLTHSQLESLSPEAVHSAISTLNQVSGWARSQVIILSAKYLAHQKVLSFYNISQMGVLLAGVGTQAFHTMDRRDLMQLLRSATSLHVSDLSPAQQHAVLSKVMEAGDTASGIVKIQGALFKEVSLFDLWREPGFNSTVLKEKEIRRSQALFLFELLSKTTRRPEELLSAGQLLKGVTCPHIDAMSADSFLAHFQYFENNFSLLSPYQVNCLAWKYWEVSRSSMPPFLLAALPARYLASIPASQCVPFLISLGKSQLDSLVLDSHKKNSILKKVQQCLSHTIADEYTVDILGNLLCHLPAAVIRRGLSPRAWATALRGLRDCLDLSPQQKAALRLRLLEQHGLPQNWTAETAKDLESFLVIFSGDELSSVATKFPDILQQTASKMAGTLPPKEFLQAVFESVRNSSAEKPSRDPSPGCHGIMAPSSNDIIKLAEANACWAPEDLLCLEEDTFLRSVELLGAVRSFSLAQLRKLKEKAVQVWDMPSSWREYHIVSLGRIALALNESELEQLDLSSIDTVASLSQQTEWTPGQAKSILQGFLEDSGYRVQDLKSFHLVGLGAALCAMNITEISLIKILEFRVVVARIGTLLCSTQVLAEFKRKAEVVFGEPTEWSSFVLQELGTIAAGLTKEELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTPAQRRQLSMLQLQSLQRAIDGAKARSWLDAPPSASPARTPSSLSPPGVWVSRGLGLGYLLLVLMPKLVW", "length": 1048, "header": "tr|A0AAA9SB25-1|A0AAA9SB25_BOVIN Computationally mapped isoform of Otoancorin OS=Bos taurus OX=9913 GN=OTOA PE=4 SV=1 CANONICAL=E1BGM5-1" }, "locus": { "chromosome": "25", "start_pos": 20235579, "end_pos": 20172353, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079382.1" } ] } }, { "isoform_ac": "E1BGM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM5/entry#E1BGM5-1", "sequence": { "sequence": "MSQEPWRCSLWLFLFLSHGVASYSVPDSQDLHPLLQKMAEEIIDGSYLNALLDLIQFQSSQVWTSDLSHRVLAYLNSRNVAFTIPSLKAAMENLLEQRLYQPQKLLEDLRGTDAQQFHTAMKYLLEDKKDRLELDDIIIDLGEVRKQALQSPGVNRSLFLITLERCFQVLNPLDCVEILGRVLRGSSGRFLQPDITEMLPRDLREDAFKNLSALFKDLYDQTSAHAQRAVYCWMTGVLKTSSNVTDDSFSWVSAENLWILGRYMVHLPFEEIMRISPMEIGLFISYDNATKQLDTVYDVTPELAQAFLERISSSNFDMRNTSTIHRLGLLVCFYDDLELLDAAVAQVLLHQMIKCSHLRGFQAGVQKLKAELLEIATENQTLNETLGSLSDAVVGLTHSQLESLSPEAVHSAISTLNQVSGWARSQVIILSAKYLAHQKVLSFYNISQMGVLLAGVGTQAFHTMDRRDLMQLLRSATSLHVSDLSPAQQHAVLSKVMEAGDTASGIVKIQGALFKEVSLFDLWREPGFNSTVLKEKEIRRSQALFLFELLSKTTRRPEELLSAGQLLKGVTCPHIDAMSADSFLAHFQYFENNFSLLSPYQVNCLAWKYWEVSRSSMPPFLLAALPARYLASIPASQCVPFLISLGKSQLDSLVLDSHKKNSILKKVQQCLSHTIADEYTVDILGNLLCHLPAAVIRRGLSPRAWATALRGLRDCLDLSPQQKAALRLRLLEQHGLPQNWTAETAKDLESFLVIFSGDELSSVATKFPDILQQTASKMAGTLPPKEFLQAVFESVRNSSAEKPSRDPSPGCHGIMAPSSNDIIKLAEANACWAPEDLLCLEEDTFLRSVELLGAVRSFSLAQLRKLKEKAVQVWDMPSSWREYHIVSLGRIALALNESELEQLDLSSIDTVASLSQQTEWTPGQAKSILQGFLEDSGYRVQDLKSFHLVGLGAALCAMNITEISLIKILEFRVVVARIGTLLCSTQVLAEFKRKAEVVFGEPTEWSSFVLQELGTIAAGLTKEELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTPAQRRQLSMLQLQSLQRAIDGAKARSWLDAPPSASPARTPSSLSPPGVLQGLGLGYLLLVLMPKLVW", "length": 1136, "header": "tr|E1BGM5-1|E1BGM5_BOVIN Isoform 1 of Otoancorin OS=Bos taurus OX=9913 GN=OTOA PE=4 SV=4 CANONICAL=E1BGM5-1" }, "locus": { "chromosome": "25", "start_pos": 20235579, "end_pos": 20165984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025120.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025120.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025120.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025120.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1069, "start_aa": "Thr", "end_pos": 1069, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1069", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BGM5", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1BGM5", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "E1BGM5", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 445, "end_pos": 447, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" }, { "start_pos": 797, "end_pos": 799, "annotation": "n_glycosylation_sequon" }, { "start_pos": 896, "end_pos": 898, "annotation": "n_glycosylation_sequon" }, { "start_pos": 959, "end_pos": 961, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1136, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGM5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM5" }, { "id": "PF28491", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28491" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Otoancorin N-terminal", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 152, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1069 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 288, "end_pos": 290 }, { "start_pos": 320, "end_pos": 322 }, { "start_pos": 379, "end_pos": 381 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 445, "end_pos": 447 }, { "start_pos": 529, "end_pos": 531 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 739, "end_pos": 741 }, { "start_pos": 797, "end_pos": 799 }, { "start_pos": 896, "end_pos": 898 }, { "start_pos": 959, "end_pos": 961 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGM7-1", "uniprot_ac": "E1BGM7", "uniprot_id": "E1BGM7_BOVIN", "mass": { "chemical_mass": 235350.0, "monoisotopic_mass": 235350.0 }, "refseq": { "ac": "NP_001179259", "name": "tudor domain-containing protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179259" }, "gene_names": [ { "name": "TDRD6", "type": "recommended", "evidence": [ { "id": "E1BGM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ] }, { "name": "TDRD6", "type": "synonym", "evidence": [ { "id": "NP_001179259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179259" } ] } ], "protein_names": [ { "name": "Tudor domain containing 6", "type": "synonym", "evidence": [ { "id": "E1BGM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM7/entry#names_and_taxonomy" } ] }, { "name": "tudor domain-containing protein 6", "type": "synonym", "evidence": [ { "id": "NP_001179259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179259" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TDRD6", "url": "https://www.uniprot.org/uniprotkb/E1BGM7", "locus": { "chromosome": "23", "start_pos": 19922053, "end_pos": 19910664, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009978", "url": "https://www.ensembl.org/id/ENSBTAG00000009978" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009978", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009978", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20425", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20425", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512705", "url": "https://www.ncbi.nlm.nih.gov/gene/512705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512705", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FKEQMFP", "url": "https://omabrowser.org/oma/group/FKEQMFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGM7", "url": "https://www.orthodb.org/?gene=E1BGM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22948", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22948", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22948:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22948:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179259", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TIM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGM7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCSTPGLPTPGASLVLRVSFVDVQPEVIPVQLWGLLGERRDEYVRLSREIQEAAAAARGPWMLGGASAFPGELCLVQVGRLWHRGRVVSRQAQESRVFLLDEGCTIAAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGAGGGEPQHWAPRAVDFLSHLQGKEVHGRVLDVLLLHRLVLLEVPELSQQMQELGLARQVPDSVFRSLLKRYLSASTPVVVPRVPPKQEQPGLDYFYPQLQLGVTEPMVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRGSPGTGDEHSTSAPWEEREESPDKPGSPCASCGLDGLWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHVYYVTLYGEDGINLNCVFGVQSCCLADQFLQSQGREEEEEEEEPETAFQCQSSAEEMDEEISLPTLPSIKLKMNTFYDAQVEFVKNPSEFWIRLRKHNGTFSKLMKKMCSFYASASKLDGVILKPEADDLCCVKWKENGYFRAMVTRLEDQNVDVFLVDRGNSENVDRYDVRMLLPQFRRLPILALQCTLADIWPLEENWSQEAISFFKKTVLHKELVIHVLDKQDNQYIIEILDESRTGEENISKVMAQAGFAKYQEFETQDSLSVSVHSPGHVSNHFTIDGNRISSAKKEEQKAMRDGKTTAVPEVVTDTTVTTNVSAGLVQDNEKRVSVYSPLVQNFLGIEPGSSCKGELQVGTTVEVSVSCVENPGYFWCQLTRNTQRFKALMCSIQDYCNNTAPPHQGTTPACLAKRTADGKWSRALITGAQSSEYVNIIFVDYGDKEMVSVKNIYSITEEFLMAKVQAFRCSLYNLIQPMGQNPFLWDEKAIQAFIEFIDNAQENSLELKCTIFALASIHDELFNVVDLLTPFQSVCHFLVQKRLARPVKFQKPLEFSVKLHSYFYSTHDMKIGSEESVYITHVDDPWAFYCQLGRNASILEQLSHHITQLSQVLLHLRTSHLVPGTLCLAKYTDGNWCRGVIIEKEPNKVFFVDFGNICVVTSDDLCPVPSDAHDVLLWPMQAIKCSLSDIPDHIPEEVTAWFRETVLDKSLKALVVAKDPDGRLIIELYNDSIQINANINEKLGLRGYKGGTRRKKSKALLSTTETLEVKKEDVKLSPTEYLSKSENKPDGKALLGESYKPKISSACRELKFLQSSTKTNLVTLHQDSVGNKNNQVSPLTTDKKLESSAEPSLKATKLEASLSERKLRDSCDKGLPLKISEFPKKAIMPGFKTTVYVSHINDLSDFYVQLTEDEAEIDHLSERLNDTRTRPEYYAGPPLQRGDVICAVFPEDNLWYRAVVKEPQLNDLLSVQFIDYGNVSVVHTNKIGKLDRVNVLLPGLCIPCSLKGCGVPGILNHKEVMHYFSQRTNETQIRCEFVQFQDKWEVTLADEHGIIAEDMVSRYTFSEKSQLGFSTQIVQGACSTLVSKTDVDTSMFLNWYNPKMKTIRAYATVIDGPEYFWCQFADTKKLQHLEVEVQTVGEQVTDRRSRIHCPRIGDPCIVRYREDGHYYRALVTSICEDYLVSIRLVDFGNIVDSVDPKALWNIPSELLAVPMQAFPCCLSGFTISQGACPREGCDYFYEIVTEDVLEITILDIKRDVGDIPLAIVDLKSKGESISEKMKKYSKIDMRSSDLRYEKNDAEVKGALGVPSPDVGLKKSSSKTGRERILHVESQTAELLERLNKDLNILETQPGKFYDPKTDNIFEAFENPGKNKIGTELLEEKVKGLLGDKTKFDDKYPMPGFNTFLPHATEAKEVLELNSLEVPLSPDDESKEFLELESIELQHSLVGDEEKEDLDLVPPTMTLPQGCDPEVTLPPLPGQLPLNCEDEKQPELELPTAQLCLEDRINPLSLTASQKAQEALCTEDMRGSSCAESFDEERRLRLRRQTCDAKMQIEMSIFKEEFTECTSRDAVSSLTSLFSEEEYKDARKHNYTLPDHIPAQPENTYTLKGFTVGSKCVVWSSLRNTWSKCEILEIAEEGTKVLDLSNGIEEVVNPENVWNGIPKLDRSPSEKRGLEMIQI", "length": 2092, "header": "tr|E1BGM7-1|E1BGM7_BOVIN Isoform 1 of Tudor domain containing 6 OS=Bos taurus OX=9913 GN=TDRD6 PE=4 SV=1 CANONICAL=E1BGM7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM7/entry#A0AAA9TIM5-1", "sequence": { "sequence": "MCSTPGLPTPGASLVLRVSFVDVQPEVIPVQLWGLLGERRDEYVRLSREIQEAAAAARGPWMLGGASAFPGELCLVQVGRLWHRGRVVSRQAQESRVFLLDEGCTIAAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGAGGGEPQHWAPRAVDFLSHLQGKEVHGRVLDVLLLHRLVLLEVPELSQQMQELGLARQVPDSVFRSLLKRYLSASTPVVVPRVPPKQEQPGLDYFYPQLQLGVTEPMVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRGSPGTGDEHSTSAPWEEREESPDKPGSPCASCGLDGLWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHVYYVTLYGEDGINLNCVFGVQSCCLADQFLQSQGREEEEEEEEPETAFQCQSSAEEMDEEISLPTLPSIKLKMNTFYDAQVEFVKNPSEFWIRLRKHNGTFSKLMKKMCSFYASASKLDGVILKPEADDLCCVKWKENGYFRAMVTRLEDQNVDVFLVDRGNSENVDRYDVRMLLPQFRRLPILALQCTLADIWPLEENWSQEAISFFKKTVLHKELVIHVLDKQDNQYIIEILDESRTGEENISKVMAQAGFAKYQEFETQDSLSVSVHSPGHVSNHFTIDGNRISSAKKEEQKAMRDGKTTAVPEVVTDTTVTTNVSAGLVQDNEKRVSVYSPLVQNFLGIEPGSSCKGELQVGTTVEVSVSCVENPGYFWCQLTRNTQRFKALMCSIQDYCNNTAPPHQGTTPACLAKRTADGKWSRALITGAQSSEYVNIIFVDYGDKEMVSVKNIYSITEEFLMAKVQAFRCSLYNLIQPMGQNPFLWDEKAIQAFIEFIDNAQENSLELKCTIFALASIHDELFNVVDLLTPFQSVCHFLVQKRLARPVKFQKPLEFSVKLHSYFYSTHDMKIGSEESVYITHVDDPWAFYCQLGRNASILEQLSHHITQLSQVLLHLRTSHLVPGTLCLAKYTDGNWCRGVIIEKEPNKVFFVDFGNICVVTSDDLCPVPSDAHDVLLWPMQAIKCSLSDIPDHIPEEVTAWFRETVLDKSLKALVVAKDPDGRLIIELYNDSIQINANINEKLGLRGYKGGTRRKKSKALLSTTETLEVKKEDVKLSPTEYLSKSENKPDGKALLGESYKPKISSACRELKFLQSSTKTNLVTLHQDSVGNKNNQVSPLTTDKKLESSAEPSLKATKLEASLSERKLRDSCDKGLPLKISEFPKKAIMPGFKTTVYVSHINDLSDFYVQLTEDEAEIDHLSERLNDTRTRPEYYAGPPLQRGDVICAVFPEDNLWYRAVVKEPQLNDLLSVQFIDYGNVSVVHTNKIGKLDRVNVLLPGLCIPCSLKGCGVPGILNHKEVMHYFSQRTNETQIRCEFVQFQDKWEVTLADEHGIIAEDMVSRYTFSEKSQLGFSTQIVQGACSTLVSKTDVDTSMFLNWYNPKMKTIRAYATVIDGPEYFWCQFADTKKLQHLEVEVQTVGEQVTDRRSRIHCPRIGDPCIVRYREDGHYYRALVTSICEDYLVSIRLVDFGNIVDSVDPKALWNIPSELLAVPMQAFPCCLSGFTISQGACPREGCDYFYEIVTEDVLEITILDIKRDVGDIPLAIVDLKSKGESISEKMKKYSKIDMRSSDLRYEKNDAEVKGALGVPSPDVGLKKSSSKTGRERILHVESQTAELLERLNKDLNILETQPGKFYDPKTDNIFEAFENPGKNKIGTELLEEKVKGLLGDKTKFDDKYPMPGFNTFLPHATEAKEVLELNSLEVPLSPDDESKEFLELESIELQHSLVGDEEKEDLDLVPPTMTLPQGCDPEVTLPPLPGQLPLNCEDEKQPELELPTAQLCLEDRINPLSLTASQKAQEALCTEDMRGSSCAESFDEERRLRLRRQTCDAKMQIEMSIFKEEFTECTSRDAVSSLTSLFSEEEYKDARKHNYTLPDHIPAQPENTYTLKGFTVGSKCVVWSSLRNTWSKCEILEIAEEGTKKRGLEMIQI", "length": 2062, "header": "tr|A0AAA9TIM5-1|A0AAA9TIM5_BOVIN Computationally mapped isoform of Tudor domain containing 6 OS=Bos taurus OX=9913 GN=TDRD6 PE=4 SV=1 CANONICAL=E1BGM7-1" }, "locus": { "chromosome": "23", "start_pos": 19921521, "end_pos": 19910664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114847.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114847.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096758.1" } ] } }, { "isoform_ac": "E1BGM7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGM7/entry#E1BGM7-1", "sequence": { "sequence": "MCSTPGLPTPGASLVLRVSFVDVQPEVIPVQLWGLLGERRDEYVRLSREIQEAAAAARGPWMLGGASAFPGELCLVQVGRLWHRGRVVSRQAQESRVFLLDEGCTIAAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGAGGGEPQHWAPRAVDFLSHLQGKEVHGRVLDVLLLHRLVLLEVPELSQQMQELGLARQVPDSVFRSLLKRYLSASTPVVVPRVPPKQEQPGLDYFYPQLQLGVTEPMVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRGSPGTGDEHSTSAPWEEREESPDKPGSPCASCGLDGLWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHVYYVTLYGEDGINLNCVFGVQSCCLADQFLQSQGREEEEEEEEPETAFQCQSSAEEMDEEISLPTLPSIKLKMNTFYDAQVEFVKNPSEFWIRLRKHNGTFSKLMKKMCSFYASASKLDGVILKPEADDLCCVKWKENGYFRAMVTRLEDQNVDVFLVDRGNSENVDRYDVRMLLPQFRRLPILALQCTLADIWPLEENWSQEAISFFKKTVLHKELVIHVLDKQDNQYIIEILDESRTGEENISKVMAQAGFAKYQEFETQDSLSVSVHSPGHVSNHFTIDGNRISSAKKEEQKAMRDGKTTAVPEVVTDTTVTTNVSAGLVQDNEKRVSVYSPLVQNFLGIEPGSSCKGELQVGTTVEVSVSCVENPGYFWCQLTRNTQRFKALMCSIQDYCNNTAPPHQGTTPACLAKRTADGKWSRALITGAQSSEYVNIIFVDYGDKEMVSVKNIYSITEEFLMAKVQAFRCSLYNLIQPMGQNPFLWDEKAIQAFIEFIDNAQENSLELKCTIFALASIHDELFNVVDLLTPFQSVCHFLVQKRLARPVKFQKPLEFSVKLHSYFYSTHDMKIGSEESVYITHVDDPWAFYCQLGRNASILEQLSHHITQLSQVLLHLRTSHLVPGTLCLAKYTDGNWCRGVIIEKEPNKVFFVDFGNICVVTSDDLCPVPSDAHDVLLWPMQAIKCSLSDIPDHIPEEVTAWFRETVLDKSLKALVVAKDPDGRLIIELYNDSIQINANINEKLGLRGYKGGTRRKKSKALLSTTETLEVKKEDVKLSPTEYLSKSENKPDGKALLGESYKPKISSACRELKFLQSSTKTNLVTLHQDSVGNKNNQVSPLTTDKKLESSAEPSLKATKLEASLSERKLRDSCDKGLPLKISEFPKKAIMPGFKTTVYVSHINDLSDFYVQLTEDEAEIDHLSERLNDTRTRPEYYAGPPLQRGDVICAVFPEDNLWYRAVVKEPQLNDLLSVQFIDYGNVSVVHTNKIGKLDRVNVLLPGLCIPCSLKGCGVPGILNHKEVMHYFSQRTNETQIRCEFVQFQDKWEVTLADEHGIIAEDMVSRYTFSEKSQLGFSTQIVQGACSTLVSKTDVDTSMFLNWYNPKMKTIRAYATVIDGPEYFWCQFADTKKLQHLEVEVQTVGEQVTDRRSRIHCPRIGDPCIVRYREDGHYYRALVTSICEDYLVSIRLVDFGNIVDSVDPKALWNIPSELLAVPMQAFPCCLSGFTISQGACPREGCDYFYEIVTEDVLEITILDIKRDVGDIPLAIVDLKSKGESISEKMKKYSKIDMRSSDLRYEKNDAEVKGALGVPSPDVGLKKSSSKTGRERILHVESQTAELLERLNKDLNILETQPGKFYDPKTDNIFEAFENPGKNKIGTELLEEKVKGLLGDKTKFDDKYPMPGFNTFLPHATEAKEVLELNSLEVPLSPDDESKEFLELESIELQHSLVGDEEKEDLDLVPPTMTLPQGCDPEVTLPPLPGQLPLNCEDEKQPELELPTAQLCLEDRINPLSLTASQKAQEALCTEDMRGSSCAESFDEERRLRLRRQTCDAKMQIEMSIFKEEFTECTSRDAVSSLTSLFSEEEYKDARKHNYTLPDHIPAQPENTYTLKGFTVGSKCVVWSSLRNTWSKCEILEIAEEGTKVLDLSNGIEEVVNPENVWNGIPKLDRSPSEKRGLEMIQI", "length": 2092, "header": "tr|E1BGM7-1|E1BGM7_BOVIN Isoform 1 of Tudor domain containing 6 OS=Bos taurus OX=9913 GN=TDRD6 PE=4 SV=1 CANONICAL=E1BGM7-1" }, "locus": { "chromosome": "23", "start_pos": 19921521, "end_pos": 19910664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013158.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013158.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013158.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013158.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 9, "start_aa": "Thr", "end_pos": 9, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr9", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512705", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512705", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXQ5-1", "protein_name": "Tudor domain-containing protein 6", "gene_name": "Tdrd6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTPGLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRGPWALGGASASPGELCLVQVGLMWHRCRVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGAGGGEPQHWSPNAVDFLSNLQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARHVPDSLFCSLLKRYLTAAGLGSSGAPVLPRAAPKQEHPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPTGTEDEDSGSATWEEREESPDKPGSPCASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADRFLQSQGIEEEEDEDEDEMEAAFQSQSPAEEMEEEVSLPSLRSIRLKMNTFYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILKPEPDDLCCVKWKENGYYRAMVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEAISFFKKTVLHKELVVHILDKQDRQYVIEILDESRTGEENISKVIAQAGYAKFQEFETKENIRLSAHSPGHVSGHFIAESSKIPSVKKVEGDQKAKNDNKTLSDPEALATVSLSNISTGQTAQDKEKVTSDPTLLMLNLLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSEPSPYEGDTRACLAKRTANGRWSRALISGAQSLEHVRVVFVDYGDKDVVSMKDILSVSDVFFKVRAQAFRCSLYNLIQPTGENPFVWDERAIQAFTGFIDNAWQNNLELKCTIFALASRHEEECFNVVDLLTPFQSACHFLVEKRLARPVKLQKPLEPSVQLHSYYYSTHDLKIGSEELVYITHADDPWTFYCQLARNTNILEQLSYHIMQLSKVLLNLRTSTLVPGTLCLAKYTDGNWYRGIIIEKEPSKVFFVDFGNTYVASDHLLPIPRDAYDVLLLPMQAVKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELYDESVQINASINEKLGLLGYKNRTRRKDKENEIILRETETLQDKAEIMKPSPTDYLGKSGDSKAHGVEIMGESCKPKLSPACKELKYLQGSGKAHLVTPYQDSMGNKNDGGFLLTREKREDMFASSPMSATKLESALPERRMGEASGKDLPPKFCEFPQKTIAPGFKTSVYVSHINDLSDFYIQLIEDETEINRLSERLNDVRTRPQYHTGPPWQSGDVICAVFPEDNLWYRAVVLEQQHNDLLSVQFIDYGNMSVVHTNRTGRLGPIDAVLPALCLHCSLRGIVVPDIVGTKEMVAYFSQRTDEAQIRCEFVKFQGTWEVILADEHGIIAEDIINRFPFNGKSQAGLTTQSMKGDCSKTALKTNMDTSVFLNWYNPKMKLIKAYATVIDGPEYFWCQFADSEKLQYVETEVQNAAKQLADRKSCTQCPQIGDPCIVRYREDGHYYRALITNICDDHLASVRLVDFGNVEDCVDTNALWSIPSELLLVPMQAFPCCLSGFTVSGGVCPQEGNDYFYDIVTEDVLEITILEIKRDVCDIPLAVVELRSKGENINEKMKKYAKTGTPKSGLYSEKHGAERKGGLSSPDLGLKKPSHKIAQEKTFYMEARASELSERFEKDLNIETRPSKFYERSPRNIFNAFEHSCQGKMGSQRLEGGMDYHFVDRVKYDDTYLMTGFNPILAHASEPKELLELNSLEVPLSPDDECKEFLELESIDLQHSPAGEEDKEELGLGSPMAPLSPGCQAGATLEPFMVQLPLDCEAEKQLELELPTPQLSLEDSISPLSATVSQNMPESRSAEDERKSSCVGSSDDDDDHSASPLPHHGKGGDSPAHDEMNLSEEEFPQFENRDSAALLAPLFSEEEARGGRKGRSEVPAVELQNTYTLKGFSVGSKCVVWSSLRNTWSKCEILALAEEGTRVLNLANGVEETVSPENVWNGIPKVDKRPSEAAFQTVGKDLPFTPSDDTTIEGFFCSVSEEECGGDADSAKLNV", "length": 2136 }, "evidence": [ { "id": "E1BGM7", "url": "https://omabrowser.org/oma/group/E1BGM7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P61407-1", "protein_name": "Tudor domain-containing protein 6", "gene_name": "Tdrd6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSTPGLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRGPWALGGASASPGELCLVQVGLMWHRCRVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGTGGGEPQQWSPRAVDFLSNLQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARQVPDSLFCSLLKRYLTAAGQGSSGAPVLPRAAPKQEHPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTDDEDSGSATWEEREESPDKPGSPCASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADWFLQSQGIEEEEEEDEDEVEAAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKKTVLHKELVVHVLDKQDHQYVIEILDESRMGEENISKVIAQAGFAKFQEFETKENIRLSAHSPGHVSGHFMAEPSKITSAKKAEGDQRAKKDNKTLSVSEALADTVSLSNLSTAQDTEKVTSDPSLLMLNFLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTRVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMGENPFVWDEKAVQAFSGFIDSARQNNLELKCTVFALASRHEEEWFNVVDLLTPFQSACRFLVEKRLARPVKHQKPLEPSVQLHSYYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNINVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYTDGNWYRGIIIEKEPSKVFFVDFGNTYIAVDHLLPIPRDAHDVLLLPMQALKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELYDDSVQINASINEKLGLLGYKNRTRRKEKENEIILHETKALEDKKESVKPSLADYLGKPGESKAHSIEIMGESCKPKMGPACKELRYLQGSAKANLVPPYQDSVGNKNDGGFPLTREKKEDIFASSPMSGTKLDSALPERRMGEPSGRDLPPKFCEFPQKTIAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVCKEMVSYFSQRTDEAQIRCEFVKFQGTWEVILADEHGVIAEDMISRFPCNGNSQAGLTTQTMKGDCLKIANKPNTDTSVLLNWYNPKAKLIKAYATVIDGPEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDCVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVLDITILEIKRDVCNIPLAIVELRSKGENINEKMKKYAKTGVPKNDLSSEKRGPERKGSLASPDLGLKKPSHKIAQDKTFYGEARASELSERLEKDLNIETKTSKFYERSTRSIFNAFENSCKGKMGSERLEGSMDYHFVDRAKFDNNYLITGFNPILAHASEPKELLELSSLEVPLSADNDDECKEFLELESIELQHSPAGEEEKEELGLGSPMAPLSPGCQAGATLESFMMQLPLDCEAEKQLELKLPTPQLSLEDSISPLSAAVSQDIQGSRCSEDERKAGYMGSSDDDHSRSPLLQHGKGGNSPAHDGRNLSEEEFPQFESRDSAALLAPLFSEEEAREGRKCGSMVPAQLQSTYTLKGFSVGSKCVVWSSLRNTWSKCEILELAEEGTRVLNLSNGVEETVSPENVWNGIPKVDKRPSEAVFQTVGKDLPFMPSDDATTKGFSSVSEEEACGGDADSLSTAKLNI", "length": 2134 }, "evidence": [ { "id": "E1BGM7", "url": "https://omabrowser.org/oma/group/E1BGM7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "P granule organization", "id": "GO:0030719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030719", "evidence": [ { "database": "UniProtKB", "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "E1BGM7", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1005, "end_pos": 1007, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1140, "end_pos": 1142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1335, "end_pos": 1337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1388, "end_pos": 1390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1439, "end_pos": 1441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2003, "end_pos": 2005, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 729, "end_pos": 731, "annotation": "n_glycosylation_sequon" }, { "start_pos": 807, "end_pos": 809, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGM7" }, { "id": "PS50304", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50304" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tudor", "eco_id": "ECO_0000259", "start_pos": 305, "end_pos": 364, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 9 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1005, "end_pos": 1007 }, { "start_pos": 1140, "end_pos": 1142 }, { "start_pos": 1335, "end_pos": 1337 }, { "start_pos": 1388, "end_pos": 1390 }, { "start_pos": 1439, "end_pos": 1441 }, { "start_pos": 2003, "end_pos": 2005 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 729, "end_pos": 731 }, { "start_pos": 807, "end_pos": 809 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGP0-1", "uniprot_ac": "E1BGP0", "uniprot_id": "E1BGP0_BOVIN", "mass": { "chemical_mass": 26815.0, "monoisotopic_mass": 26815.0 }, "refseq": { "ac": "XP_002698037", "name": "immunoglobulin superfamily member 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698037" }, "gene_names": [ { "name": "IGSF6", "type": "recommended", "evidence": [ { "id": "E1BGP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP0" } ] }, { "name": "IGSF6", "type": "synonym", "evidence": [ { "id": "XP_002698037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698037" } ] } ], "protein_names": [ { "name": "Immunoglobulin superfamily member 6", "type": "synonym", "evidence": [ { "id": "E1BGP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP0/entry#names_and_taxonomy" } ] }, { "name": "immunoglobulin superfamily member 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698037", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698037" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGP0", "url": "https://www.uniprot.org/uniprotkb/E1BGP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGSF6", "url": "https://www.uniprot.org/uniprotkb/E1BGP0", "locus": { "chromosome": "25", "start_pos": 20132170, "end_pos": 20142635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018869", "url": "https://www.ensembl.org/id/ENSBTAG00000018869" } ] } } ], "crossref": [ { "id": "E1BGP0", "url": "https://alphafold.ebi.ac.uk/entry/E1BGP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100140740", "url": "https://www.ncbi.nlm.nih.gov/gene/100140740", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140740", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140740", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BGP0", "url": "https://www.orthodb.org/?gene=E1BGP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15297", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15297", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15297:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15297:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698037", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698037", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGP0", "url": "https://www.uniprot.org/uniprotkb/E1BGP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGP0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METVNRGKIILGLEFNLILFYVGVADDCTVSVSQPPELQVDYMQKVVTLPCSFSTVGCPAEQPKCLWFRYGTHESKNLCLNGCRSKTDKYTLENPAQNQVSLTVNRLTFNDSAIYVCGIAFPNSKQPRAKQTGRGTVLVVREMKVLSKELQSALIALLVLFSIYITSVLVILIVLTKAKSNTQRKNETEESQKKKSARRIFQEIAQELYSKRQQTSQQTEKDNTYENRAALSNYERP", "length": 237, "header": "tr|E1BGP0-1|E1BGP0_BOVIN Isoform 1 of Immunoglobulin superfamily member 6 OS=Bos taurus OX=9913 GN=IGSF6 PE=4 SV=1 CANONICAL=E1BGP0-1" }, "isoforms": [ { "isoform_ac": "E1BGP0-1", "url": "https://www.uniprot.org/uniprotkb/E1BGP0/entry#E1BGP0-1", "sequence": { "sequence": "METVNRGKIILGLEFNLILFYVGVADDCTVSVSQPPELQVDYMQKVVTLPCSFSTVGCPAEQPKCLWFRYGTHESKNLCLNGCRSKTDKYTLENPAQNQVSLTVNRLTFNDSAIYVCGIAFPNSKQPRAKQTGRGTVLVVREMKVLSKELQSALIALLVLFSIYITSVLVILIVLTKAKSNTQRKNETEESQKKKSARRIFQEIAQELYSKRQQTSQQTEKDNTYENRAALSNYERP", "length": 237, "header": "tr|E1BGP0-1|E1BGP0_BOVIN Isoform 1 of Immunoglobulin superfamily member 6 OS=Bos taurus OX=9913 GN=IGSF6 PE=4 SV=1 CANONICAL=E1BGP0-1" }, "locus": { "chromosome": "25", "start_pos": 20142436, "end_pos": 20133174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025119.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025119.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025119.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025119.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140740", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 237, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGP0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGP0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 117, "start_aa": "Gln", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 186, "end_pos": 188 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGQ4-1", "uniprot_ac": "E1BGQ4", "uniprot_id": "E1BGQ4_BOVIN", "mass": { "chemical_mass": 106588.0, "monoisotopic_mass": 106588.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF316", "type": "recommended", "evidence": [ { "id": "E1BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ] } ], "protein_names": [ { "name": "Zinc finger protein 316", "type": "recommended", "evidence": [ { "id": "E1BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1M7D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7D6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF316", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4", "locus": { "chromosome": "25", "start_pos": 38471159, "end_pos": 38458635, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003953", "url": "https://www.ensembl.org/id/ENSBTAG00000003953" } ] } } ], "crossref": [ { "id": "E1BGQ4", "url": "https://alphafold.ebi.ac.uk/entry/E1BGQ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003953", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003953", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BGQ4", "url": "https://www.orthodb.org/?gene=E1BGQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M7D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7D6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7D6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGQ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPRTTPDSPAAQLERLDGSECGPDQEEEEEEGKGDQVEALEERLAEEVVVDADVEVDATVEAALAGEQSPASGTQECPHGGRDTESPGLQEKALQAFRAPATPRDEDLEREGEGDEEEEDEDEVDSLTSGSQGLVTFEDVAVYFSLEEWERLDAEQRELYKEVMRENYGILVSLGYPVPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEDDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGLDPGGLGVLAPGSESKPFLPDREPGASLLAPWAFPAAVAVPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCDECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCPHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEPGSEGPRPEPCSETRPAAGPEEAEVGPEGLEGPEIDEADGETEGEAEVREAAVEAPTPRSKDDPEPDRRFLGLGNGLGEGEGPSSHPLGFHFPMHPKSWLHPDGFPILGLPDFGERLPADGRPLPGPLGGRLSLVEGAGLACDPFGGGAGPGGASGLRAFGPAVGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCTDCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGAAGAPVQAPAAPVPKAEAPAKGPPSAGTGTGPGEHGSTLLEFAGGTSFGSEPTAAFAGPSGAYEETIL", "length": 989, "header": "tr|E1BGQ4-1|E1BGQ4_BOVIN Isoform 1 of Zinc finger protein 316 OS=Bos taurus OX=9913 GN=ZNF316 PE=3 SV=1 CANONICAL=E1BGQ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M7D6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4/entry#A0A3Q1M7D6-1", "sequence": { "sequence": "MAAPRTTPDSPAAQLERLDGSECGPDQEEEEEEGKGDQVEAALAGEQSPASGTQECPHGGRDTESPGLQEKALQAFRAPATPRDEDLEREGEGDEEEEDEDEVDSLTSGSQGLVTFEDVAVYFSLEEWERLDAEQRELYKEVMRENYGILVSLGYPVPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEDDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGLDPGGLGVLAPGSESKPFLPDREPGASLLAPWAFPAAVAVPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCDECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCPHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEPGSEGPRPEPCSETRPAAGPEEAEVGPEGLEGPEIDEADGETEGEAEVREAAVEAPTPRSKDDPEPDRRFLGLGNGLGEGEGPSSHPLGFHFPMHPKSWLHPDGFPILGLPDFGERLPADGRPLPGPLGGRLSLVEGAGLACDPFGGGAGPGGASGLRAFGPAVGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCTDCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGAAGAPVQAPAAPVPKAEAPAKGPPSAGTGTGPGEHGSTLLEFAGGTSFGSEPTAAFAGPSGAYEETIL", "length": 966, "header": "tr|A0A3Q1M7D6-1|A0A3Q1M7D6_BOVIN Computationally mapped isoform of Zinc finger protein 316 OS=Bos taurus OX=9913 GN=ZNF316 PE=3 SV=2 CANONICAL=E1BGQ4-1" }, "locus": { "chromosome": "25", "start_pos": 38470155, "end_pos": 38462716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078904.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078904.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069711.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069711.2" } ] } }, { "isoform_ac": "E1BGQ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4/entry#E1BGQ4-1", "sequence": { "sequence": "MAAPRTTPDSPAAQLERLDGSECGPDQEEEEEEGKGDQVEALEERLAEEVVVDADVEVDATVEAALAGEQSPASGTQECPHGGRDTESPGLQEKALQAFRAPATPRDEDLEREGEGDEEEEDEDEVDSLTSGSQGLVTFEDVAVYFSLEEWERLDAEQRELYKEVMRENYGILVSLGYPVPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEDDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGLDPGGLGVLAPGSESKPFLPDREPGASLLAPWAFPAAVAVPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCDECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCPHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEPGSEGPRPEPCSETRPAAGPEEAEVGPEGLEGPEIDEADGETEGEAEVREAAVEAPTPRSKDDPEPDRRFLGLGNGLGEGEGPSSHPLGFHFPMHPKSWLHPDGFPILGLPDFGERLPADGRPLPGPLGGRLSLVEGAGLACDPFGGGAGPGGASGLRAFGPAVGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCTDCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGAAGAPVQAPAAPVPKAEAPAKGPPSAGTGTGPGEHGSTLLEFAGGTSFGSEPTAAFAGPSGAYEETIL", "length": 989, "header": "tr|E1BGQ4-1|E1BGQ4_BOVIN Isoform 1 of Zinc finger protein 316 OS=Bos taurus OX=9913 GN=ZNF316 PE=3 SV=1 CANONICAL=E1BGQ4-1" }, "locus": { "chromosome": "25", "start_pos": 38470155, "end_pos": 38462716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005167.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005167.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005167.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005167.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 547, "start_aa": "Thr", "end_pos": 547, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr547", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BGQ4", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGQ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 989, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGQ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGQ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 324, "end_pos": 351, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ4" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 208, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 547 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGQ6-1", "uniprot_ac": "E1BGQ6", "uniprot_id": "E1BGQ6_BOVIN", "mass": { "chemical_mass": 18541.0, "monoisotopic_mass": 18541.0 }, "refseq": { "ac": "NP_001178972", "name": "transmembrane protein 220", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178972" }, "gene_names": [ { "name": "TMEM220", "type": "recommended", "evidence": [ { "id": "E1BGQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6" } ] }, { "name": "TMEM220", "type": "synonym", "evidence": [ { "id": "NP_001178972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178972" } ] } ], "protein_names": [ { "name": "Transmembrane protein 220", "type": "synonym", "evidence": [ { "id": "E1BGQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 220", "type": "synonym", "evidence": [ { "id": "NP_001178972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178972" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGQ6", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM220", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6", "locus": { "chromosome": "19", "start_pos": 29676159, "end_pos": 29693619, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003958", "url": "https://www.ensembl.org/id/ENSBTAG00000003958" } ] } } ], "crossref": [ { "id": "E1BGQ6", "url": "https://alphafold.ebi.ac.uk/entry/E1BGQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003958", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003958", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504970", "url": "https://www.ncbi.nlm.nih.gov/gene/504970", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504970", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504970", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WAPALWR", "url": "https://omabrowser.org/oma/group/WAPALWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGQ6", "url": "https://www.orthodb.org/?gene=E1BGQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34262:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34262:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178972", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGQ6", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAAGRGARGLWRACNWLMGAFFALAAFVQVNDPDAELWVVMYTIPATLTLLVGLNPLVTGNFIWKSVSAIHIFLCVLWAISLAYNLLLHKKQNLLHEEEGRELFGLVIITAWLGLCHSSSKAPGGGRIQLAIATTVAFLPFISWVYIYINKEMRSSWPDHCKTVI", "length": 167, "header": "tr|E1BGQ6-1|E1BGQ6_BOVIN Isoform 1 of Transmembrane protein 220 OS=Bos taurus OX=9913 GN=TMEM220 PE=4 SV=1 CANONICAL=E1BGQ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9A1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6/entry#A0AAA9S9A1-1", "sequence": { "sequence": "MAPAAGRGARGLWRACNWLMGAFFALAAFVQVMYTIPATLTLLVGLNPLVTGNFIWKSVSAIHIFLCVLWAISLAYNLLLHKKQNLLHEEEGRELFGLVIITAWLGLCHSSSKAPGGGRIQLAIATTVAFLPFISWVYIYINKEMRSSWPDHCKTVI", "length": 157, "header": "tr|A0AAA9S9A1-1|A0AAA9S9A1_BOVIN Computationally mapped isoform of Transmembrane protein 220 OS=Bos taurus OX=9913 GN=TMEM220 PE=4 SV=1 CANONICAL=E1BGQ6-1" }, "locus": { "chromosome": "19", "start_pos": 29693358, "end_pos": 29677797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079970.1" } ] } }, { "isoform_ac": "E1BGQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BGQ6/entry#E1BGQ6-1", "sequence": { "sequence": "MAPAAGRGARGLWRACNWLMGAFFALAAFVQVNDPDAELWVVMYTIPATLTLLVGLNPLVTGNFIWKSVSAIHIFLCVLWAISLAYNLLLHKKQNLLHEEEGRELFGLVIITAWLGLCHSSSKAPGGGRIQLAIATTVAFLPFISWVYIYINKEMRSSWPDHCKTVI", "length": 167, "header": "tr|E1BGQ6-1|E1BGQ6_BOVIN Isoform 1 of Transmembrane protein 220 OS=Bos taurus OX=9913 GN=TMEM220 PE=4 SV=1 CANONICAL=E1BGQ6-1" }, "locus": { "chromosome": "19", "start_pos": 29693358, "end_pos": 29677797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005162.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005162.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005162.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005162.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504970", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504970", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ABR6-1", "protein_name": "Transmembrane protein 220", "gene_name": "TMEM220", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPAAGGWAQGLWRACNWLMGAFFALAAFVQVNDPDAELWVVVYTIPAGLTLLVGLNPLVTGSFIWKSVCTIHILFCIVWAAGLAYNLLLHTKQNIFHEEEGRELFGLVIITAWMSLCHSSSENPAGGRIRLAIAIAVALFPFISWVYIYVNKEMRSSWPAHCKTVI", "length": 167 }, "evidence": [ { "id": "E1BGQ6", "url": "https://omabrowser.org/oma/group/E1BGQ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A2I6-1", "protein_name": "Transmembrane protein 220", "gene_name": "Tmem220", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASAVAPWAPGLWRACNALMAAFFALAAVVQVNDPDAELWVVVYMIPAVLTLLVGFNPLVTGNCIWKSVSAIHMLFCALWAGGLAYHFLLHAKQSILNEEEGRELSGLVIVTAWMALCHSSSKNSVGGRMHLAIAVVITLFPLLSWVYVYMNKEMRSSWPTHCKTVI", "length": 167 }, "evidence": [ { "id": "E1BGQ6", "url": "https://omabrowser.org/oma/group/E1BGQ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FET6-1", "protein_name": "Transmembrane protein 220", "gene_name": "tmem220", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNKNGVSVFQTIWRVCNLFMSVFFSLATYVQINDPDAALWMVGYAIPAVLCFLIFCQQQITESLLWRRIADLHVLVASTFGVILAWKLYKEGITDIFQQEEGRECCGLLLTVFWLLLCRHSGRSSTIGSVRIFTAVGISVFPFVTWLYYYMNKELRKHWPEHCTTAL", "length": 167 }, "evidence": [ { "id": "E1BGQ6", "url": "https://omabrowser.org/oma/group/E1BGQ6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6QAJ8-1", "protein_name": "Transmembrane protein 220", "gene_name": "TMEM220", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPALWRACNGLMAAFFALAALVQVNDPDAEVWVVVYTIPAVLTLLVGLNPEVTGNVIWKSISAIHILFCTVWAVGLASYLLHRTQQNILHEEEGRELSGLVIITAWIILCHSSSKNPVGGRIQLAIAIVITLFPFISWVYIYINKEMRSSWPTHCKTVI", "length": 160 }, "evidence": [ { "id": "E1BGQ6", "url": "https://omabrowser.org/oma/group/E1BGQ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGQ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 167, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGQ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGQ6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGS4-1", "uniprot_ac": "E1BGS4", "uniprot_id": "E1BGS4_BOVIN", "mass": { "chemical_mass": 63289.0, "monoisotopic_mass": 63289.0 }, "refseq": { "ac": "XP_002685114", "name": "alpha-taxilin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685114" }, "gene_names": [ { "name": "TXLNA", "type": "recommended", "evidence": [ { "id": "E1BGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGS4" } ] }, { "name": "TXLNA", "type": "synonym", "evidence": [ { "id": "XP_002685114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685114" } ] } ], "protein_names": [ { "name": "Taxilin alpha", "type": "synonym", "evidence": [ { "id": "E1BGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGS4/entry#names_and_taxonomy" } ] }, { "name": "alpha-taxilin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002685114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685114" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGS4", "url": "https://www.uniprot.org/uniprotkb/E1BGS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TXLNA", "url": "https://www.uniprot.org/uniprotkb/E1BGS4", "locus": { "chromosome": "1", "start_pos": 158218010, "end_pos": 158228741, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012867", "url": "https://www.ensembl.org/id/ENSBTAG00000012867" } ] } } ], "crossref": [ { "id": "E1BGS4", "url": "https://alphafold.ebi.ac.uk/entry/E1BGS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012867", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012867", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511331", "url": "https://www.ncbi.nlm.nih.gov/gene/511331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VTEAPCC", "url": "https://omabrowser.org/oma/group/VTEAPCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGS4", "url": "https://www.orthodb.org/?gene=E1BGS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16127:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16127:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09728", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09728", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-449836", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449836", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002685114", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGS4", "url": "https://www.uniprot.org/uniprotkb/E1BGS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNQDKKNGPSKQSGNTSNPKNTPGQPEAGPEGAQGRPSQSAPATEAEGSTSQAAGKAEGAQAKSAQSGALRDVSEELSRQLEDILSTYCVDNSQGGPGEDVAQGEPAEPEDAEKSRTYASRNGEPEPETPVVNGEKEISKGEPGPDEIRTSDEVVDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENVELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTLRDKELEGLQVKIQRLEKLCRALQSERNDLNKRVQDLSAGSQAPLTDSGPERRAEAANASKEQGSEGPRVQTPSSPRATEAPCCPGALSTDPSGQTGPQEPTSITA", "length": 561, "header": "tr|E1BGS4-1|E1BGS4_BOVIN Isoform 1 of Taxilin alpha OS=Bos taurus OX=9913 GN=TXLNA PE=3 SV=1 CANONICAL=E1BGS4-1" }, "isoforms": [ { "isoform_ac": "E1BGS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGS4/entry#E1BGS4-1", "sequence": { "sequence": "MKNQDKKNGPSKQSGNTSNPKNTPGQPEAGPEGAQGRPSQSAPATEAEGSTSQAAGKAEGAQAKSAQSGALRDVSEELSRQLEDILSTYCVDNSQGGPGEDVAQGEPAEPEDAEKSRTYASRNGEPEPETPVVNGEKEISKGEPGPDEIRTSDEVVDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENVELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTLRDKELEGLQVKIQRLEKLCRALQSERNDLNKRVQDLSAGSQAPLTDSGPERRAEAANASKEQGSEGPRVQTPSSPRATEAPCCPGALSTDPSGQTGPQEPTSITA", "length": 561, "header": "tr|E1BGS4-1|E1BGS4_BOVIN Isoform 1 of Taxilin alpha OS=Bos taurus OX=9913 GN=TXLNA PE=3 SV=1 CANONICAL=E1BGS4-1" }, "locus": { "chromosome": "1", "start_pos": 158228006, "end_pos": 158219014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017100.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017100.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017100.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017100.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511331", "resource": "KEGG Pathway" }, { "id": "R-BTA-449836", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449836", "resource": "Reactome", "description": "Other interleukin signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3B2W9-1", "protein_name": "Taxilin alpha", "gene_name": "TXLNA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKNQGGDTKAAPRPAAKTSGALGEEGDPSEPTAALEAPLAQEDTKSSRPAVRDVSEELSRQLEDILNTYCVDASQEGPGEDGGQSEPVEPEEVEKCRSESPRNGDQESGSPEMNGEKEGTKGTEEFRPGEECGERDQKKAQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKILQKKQTQLVQEKDHLQSEHSKAILARSKLESLCRELQRHNRTLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTLRDKELEGLQVKIQRLEKLCRALQTERNDLNKKVQDLCAHVPRADMDLTEPLKDPSREGSEAAAGGAPAEQRLAEDCLHSGKPTHSTDPAESLGELSIGALGQSGTEEGTQGAD", "length": 546 }, "evidence": [ { "id": "E1BGS4", "url": "https://omabrowser.org/oma/group/E1BGS4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H949-1", "protein_name": "Alpha-taxilin", "gene_name": "Txlna", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKNQDKKNGPAKHSNPKSSPGQREAAPEGAQGRPRQTAPAAEAEGSTNQAPGKTEGAQAKAAKSGPLCDVSEELSRQLEDILSTYCVDNNQGGPGEEGAQGEPTEPEDAEKSRTYAARNGEPEPGIPVINGEKETSKGEPGSEEVRASDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKEFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTLRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLTAGAQGSLTDIGTERRPEAATASKEQGLESPGAQPSSSPRATEVPGCPGVPSTETAGQTGPRQPTSATA", "length": 557 }, "evidence": [ { "id": "E1BGS4", "url": "https://omabrowser.org/oma/group/E1BGS4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P40222-1", "protein_name": "Alpha-taxilin", "gene_name": "TXLNA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEAPCYPGAPSTEASGQTGPQEPTSARA", "length": 546 }, "evidence": [ { "id": "E1BGS4", "url": "https://omabrowser.org/oma/group/E1BGS4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PAM1-1", "protein_name": "Alpha-taxilin", "gene_name": "Txlna", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNQDKKNGPAKHSNSKGSPGQREAGPEGAHGRPRQTAPGAEAEGSTSQAPGKTEGARAKAAQPGALCDVSEELSRQLEDILSTYCVDNNQGGPAEEGAQGEPTEPEDTEKSRTYAARNGEPEPGIPVVNGEKETSKGEPGTEEIRASDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKEFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLTAGGITDIGSERRPEATTASKEQGVESPGAQPASSPRATDAPCCSGAPSTGTAGQTGPGEPTPATA", "length": 554 }, "evidence": [ { "id": "E1BGS4", "url": "https://omabrowser.org/oma/group/E1BGS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "E1BGS4", "url": "https://www.uniprot.org/uniprotkb/E1BGS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 561, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGS4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 513, "end_pos": 515 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGV5-1", "uniprot_ac": "E1BGV5", "uniprot_id": "E1BGV5_BOVIN", "mass": { "chemical_mass": 45221.0, "monoisotopic_mass": 45221.0 }, "refseq": {}, "gene_names": [ { "name": "ZSCAN9", "type": "recommended", "evidence": [ { "id": "E1BGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 9", "type": "synonym", "evidence": [ { "id": "E1BGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSCAN9", "url": "https://www.uniprot.org/uniprotkb/E1BGV5", "locus": { "chromosome": "23", "start_pos": 30462838, "end_pos": 30467794, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040168", "url": "https://www.ensembl.org/id/ENSBTAG00000040168" } ] } } ], "crossref": [ { "id": "E1BGV5", "url": "https://alphafold.ebi.ac.uk/entry/E1BGV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040168", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040168", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIDSKEILCLDMQAPKVWEELLTEKVEAESHPQKQESRLKRSNSLAREISRRHFRQLCYQETPGPRQALTRLRKLCYQCLRPHVSTKKQILDLLVLEQFLSILPQELQGWMREHCPESGEEAVILLEDLERELDEPQHEMVAYRQEQEVLSKAVSLEAHMSLALQSQPKEPQLTLVSAQEPHPIGETGGMTQTEDRELVLRKHCPKRVEPCGKVSYGLTWEESQQGPQHGEVSEHKGGVERHWGSPVGTGPHRYEECGKSFAQSSGLVRHQRVHTGERPYECNECGKTFSRSSGLLNHRGIHNIQKRYHCKECGKAFSQSAGLIQHKRIHKGEKPYQCSQCNKSYSQHSFLIEHQRSHTGERPHHCNQCGKSFNHHCNLIRHQKIHLVAELA", "length": 393, "header": "tr|E1BGV5-1|E1BGV5_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 9 OS=Bos taurus OX=9913 GN=ZSCAN9 PE=3 SV=4 CANONICAL=E1BGV5-1" }, "isoforms": [ { "isoform_ac": "E1BGV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGV5/entry#E1BGV5-1", "sequence": { "sequence": "MNIDSKEILCLDMQAPKVWEELLTEKVEAESHPQKQESRLKRSNSLAREISRRHFRQLCYQETPGPRQALTRLRKLCYQCLRPHVSTKKQILDLLVLEQFLSILPQELQGWMREHCPESGEEAVILLEDLERELDEPQHEMVAYRQEQEVLSKAVSLEAHMSLALQSQPKEPQLTLVSAQEPHPIGETGGMTQTEDRELVLRKHCPKRVEPCGKVSYGLTWEESQQGPQHGEVSEHKGGVERHWGSPVGTGPHRYEECGKSFAQSSGLVRHQRVHTGERPYECNECGKTFSRSSGLLNHRGIHNIQKRYHCKECGKAFSQSAGLIQHKRIHKGEKPYQCSQCNKSYSQHSFLIEHQRSHTGERPHHCNQCGKSFNHHCNLIRHQKIHLVAELA", "length": 393, "header": "tr|E1BGV5-1|E1BGV5_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 9 OS=Bos taurus OX=9913 GN=ZSCAN9 PE=3 SV=4 CANONICAL=E1BGV5-1" }, "locus": { "chromosome": "23", "start_pos": 30467794, "end_pos": 30462841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056475.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056475.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050560.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050560.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "E1BGV5", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGV5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGV5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGV5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 253, "end_pos": 280, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV5" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 134, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 343, "end_pos": 345 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGW9-1", "uniprot_ac": "E1BGW9", "uniprot_id": "E1BGW9_BOVIN", "mass": { "chemical_mass": 53449.0, "monoisotopic_mass": 53449.0 }, "refseq": { "ac": "NP_001192797", "name": "probable E3 ubiquitin-protein ligase TRIML1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192797" }, "gene_names": [ { "name": "TRIML1", "type": "recommended", "evidence": [ { "id": "E1BGW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ] }, { "name": "TRIML1", "type": "synonym", "evidence": [ { "id": "NP_001192797", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192797" } ] } ], "protein_names": [ { "name": "Tripartite motif family like 1", "type": "synonym", "evidence": [ { "id": "E1BGW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGW9/entry#names_and_taxonomy" } ] }, { "name": "probable E3 ubiquitin-protein ligase TRIML1", "type": "synonym", "evidence": [ { "id": "NP_001192797", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192797" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIML1", "url": "https://www.uniprot.org/uniprotkb/E1BGW9", "locus": { "chromosome": "27", "start_pos": 17673037, "end_pos": 17666005, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008639", "url": "https://www.ensembl.org/id/ENSBTAG00000008639" } ] } } ], "crossref": [ { "id": "E1BGW9", "url": "https://alphafold.ebi.ac.uk/entry/E1BGW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008639", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13733", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13733", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16594", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16594", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520202", "url": "https://www.ncbi.nlm.nih.gov/gene/520202", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520202", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520202", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHSFCLM", "url": "https://omabrowser.org/oma/group/GHSFCLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGW9", "url": "https://www.orthodb.org/?gene=E1BGW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192797", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTADLMENLREELTCFICLDYFTSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEIPHFQPNERLGRLAGIGKQLRSQVLQSEGNQGSYERMLAATRMLSDKEPGGHNFLTQGHGVNRMNLSSEAEEHHKEKLQEILDILCKKRKETEVILNHEKERVILCKEETKTCKQVVLSEYAKMHQFLKEEEQLQLQLLEMEERENLKKLRDNEIRLTQQMRSLSKMMEQIESTCQNSIIESFEDVRGILERSEPLLLQCPEAISTELTLCHITGMREMLRKFSTDITLDPATANAYLVLSEDLKSVKHGGIRQQLPDNPERFDQSATVLGTQVFTCGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVHKVGIFLDYESGHIAFYNVTDESLIYSFPPASFQEALRPIFSPCLPNEGTNTGPLVICSLNHHV", "length": 468, "header": "tr|E1BGW9-1|E1BGW9_BOVIN Isoform 1 of Tripartite motif family like 1 OS=Bos taurus OX=9913 GN=TRIML1 PE=4 SV=2 CANONICAL=E1BGW9-1" }, "isoforms": [ { "isoform_ac": "E1BGW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGW9/entry#E1BGW9-1", "sequence": { "sequence": "MSTADLMENLREELTCFICLDYFTSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEIPHFQPNERLGRLAGIGKQLRSQVLQSEGNQGSYERMLAATRMLSDKEPGGHNFLTQGHGVNRMNLSSEAEEHHKEKLQEILDILCKKRKETEVILNHEKERVILCKEETKTCKQVVLSEYAKMHQFLKEEEQLQLQLLEMEERENLKKLRDNEIRLTQQMRSLSKMMEQIESTCQNSIIESFEDVRGILERSEPLLLQCPEAISTELTLCHITGMREMLRKFSTDITLDPATANAYLVLSEDLKSVKHGGIRQQLPDNPERFDQSATVLGTQVFTCGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVHKVGIFLDYESGHIAFYNVTDESLIYSFPPASFQEALRPIFSPCLPNEGTNTGPLVICSLNHHV", "length": 468, "header": "tr|E1BGW9-1|E1BGW9_BOVIN Isoform 1 of Tripartite motif family like 1 OS=Bos taurus OX=9913 GN=TRIML1 PE=4 SV=2 CANONICAL=E1BGW9-1" }, "locus": { "chromosome": "27", "start_pos": 17672945, "end_pos": 17666005, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011393.4", "url": "https://www.ensembl.org/id/ENSBTAT00000011393.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011393.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011393.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520202", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520202", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7IIY4-1", "protein_name": "Probable E3 ubiquitin-protein ligase TRIML1", "gene_name": "Triml1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSIQEKISTVDLMESLREELTCFICLDYFSGPVTTECGHSFCLMCLLKSWEEHNTPLSCPECWRTLGSPHFQANERLGRLASIGRQLRSQVLQNEDEQSSCGRTPGASWVFSDDEQSVINFSTQCHGINRTYFSSEAEEQHKEKLQDIINLLRKKKKEAQTILNHEKERVMLCKEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEKEEKENMKKLRENEIQLTQQVRRLGKMIGRIESTSQNLTLEEVRGAMDRCESLLLQCPETTITELSLCRITGMREMLRKFSTDVTLDPATANAYLVLSDDLKSVRHGVTRQQLPDNPERFDQSATVLGAQIFTCGRHYWEVEVGKKTEWEVGICKDSVIRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVHKVGVFLDYESGHIAFYNVTDETLIYSFPSTSFHEALRPIFSPCLPNEGTNTDPLVICHI", "length": 467 }, "evidence": [ { "id": "E1BGW9", "url": "https://omabrowser.org/oma/group/E1BGW9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A221-1", "protein_name": "Tripartite motif family-like 1", "gene_name": "Triml1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVHEKISTADLMENLREELTCFICLDYFSSPVTTECGHSFCLTCLLKSWEEHNTPLSCPECWRTLGAPHFQANERLGRLANIGRQLRCQVLQSEDEQSNSGRTPGPSRVFSDDEQSVINFSPPNHGMNRAYFSSEAEEQHKEKLQDIVNILRKRKKEAQAILNHEKERVMLCKQEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEKEEKENVKKLRENEIHLTQQVRRINKMIGRIESICQNLTLESFEEVRGAMDRYESLLFQCPETTITELSLCRITGMREMLRKFSTDITLDPATANAYLLLSDDLKSVRYGGTKQQLPDNPERFDQSATVLGAQIFTCGRHYWEVEVGKKTEWEVGICKDSVNRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVHKVGVFLDYDSGHIAFYNVTDESLIYSFPPSSFHEALRPIFSPCLPNEGTNTDPLIICHI", "length": 471 }, "evidence": [ { "id": "E1BGW9", "url": "https://omabrowser.org/oma/group/E1BGW9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BVP1-1", "protein_name": "Probable E3 ubiquitin-protein ligase TRIML1", "gene_name": "Triml1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNHEKMSTTDLMENLREELTCFICLDYFSSPVTTECGHSFCLMCLLKSWEEHNTPLSCPECWRTLGAPHFQANERLGRLANIGRQLRSQVLQSEDEQSICGRMPGPSWVFSDDEQSVINVSPPSQGTNKACFSSEAEEQHKEKLQDIINILRKKKKEVQAILNHEKERVMLCKEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEREEKANMKKLRENEIQLTQQIRRLGKMIGRIESTCQNLTLESFEEVKGAMDRYESLLFQSPETTITELSLCHITGMREMLRKFSTDITLDPATANAYLLLSEDLKSVRYGGTRQQLPDNPERFDQSATVLGAQIFTCGRHYWEVEVGKKTEWEVGICKDSVNRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVHKVGVFLDYDSGHIAFYNATDESLIYSFPPTPFHEALRPIFSPCLPNEGTNTDPLIICHI", "length": 470 }, "evidence": [ { "id": "E1BGW9", "url": "https://omabrowser.org/oma/group/E1BGW9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N9V2-1", "protein_name": "Probable E3 ubiquitin-protein ligase TRIML1", "gene_name": "TRIML1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEGPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALSDDEQGGSAFVAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESSSQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLCRITGMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTICSLNSHV", "length": 468 }, "evidence": [ { "id": "E1BGW9", "url": "https://omabrowser.org/oma/group/E1BGW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1BGW9", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGW9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 468, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGW9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGW9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 268, "end_pos": 461, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGW9" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 56, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 422, "end_pos": 424 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGX8-1", "uniprot_ac": "E1BGX8", "uniprot_id": "E1BGX8_BOVIN", "mass": { "chemical_mass": 85947.0, "monoisotopic_mass": 85947.0 }, "refseq": { "ac": "XP_002694011", "name": "HHIP-like protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694011" }, "gene_names": [ { "name": "HHIPL2", "type": "recommended", "evidence": [ { "id": "E1BGX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGX8" } ] }, { "name": "HHIPL2", "type": "synonym", "evidence": [ { "id": "XP_002694011", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694011" } ] } ], "protein_names": [ { "name": "HHIP like 2", "type": "synonym", "evidence": [ { "id": "E1BGX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGX8/entry#names_and_taxonomy" } ] }, { "name": "HHIP-like protein 2", "type": "synonym", "evidence": [ { "id": "XP_002694011", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694011" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGX8", "url": "https://www.uniprot.org/uniprotkb/E1BGX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HHIPL2", "url": "https://www.uniprot.org/uniprotkb/E1BGX8", "locus": { "chromosome": "16", "start_pos": 26010404, "end_pos": 26038058, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017561", "url": "https://www.ensembl.org/id/ENSBTAG00000017561" } ] } } ], "crossref": [ { "id": "E1BGX8", "url": "https://alphafold.ebi.ac.uk/entry/E1BGX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017561", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017561", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533766", "url": "https://www.ncbi.nlm.nih.gov/gene/533766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533766", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533766", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCDQSKD", "url": "https://omabrowser.org/oma/group/CCDQSKD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGX8", "url": "https://www.orthodb.org/?gene=E1BGX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19328:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19328:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07995", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07995", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694011", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694011", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGX8", "url": "https://www.uniprot.org/uniprotkb/E1BGX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGX8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRRSIPRGGWSRWTPWLLTSPRIFCLSLIVLLGQVGLLQGHPQCLDYRPPFQPLQHLEFCSDYESFGCCDQRKDHRIAARYWDIMEYFDLKGHELCGGYIKDILCQECSPYAAHLYDAENPRTPLRNLPGLCSDYCSAFHSNCHSAIALLTNDRRFQESPGKDGTRFCHLLNLPDKDYCFPNILRSDHLNRNLGTVAEDRRGCLQLCLAEVANRLRNPVAMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKSLVLTTPWIGDERGFLGLAFHPRFRRNRKFYIYYSCLGKKRVEKIRISEMKVSRADPNKADPKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGKFGNAQNKSSLLGKVLRIDVNGAGSGGKRYRVPMDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITHQGRGRMFCGDVGENRFEEVDIIVKGGNYGWRAKEGFECYDKKLCQNASLDDILPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKTKKWKKQDICLGSTESCAFPGLISTHSKFIISFGEDEAGELYFLATSYPSAYAPHGSIYKFVDPSRRAPPGKCKYKPVPVKTRSKRVQFRPLAKMVLDLLKEQSEKAARKLSSATLASSPNRASSQKDSFKKPASPTSSRKTSPGPGAKKRARVWSPGPQGKRKGIPKRPSGIARQAAQHRRAGRSLPPPLPSRWPLRGPEPPHHVEAAAEPDFRCAGSRGWRWEPSERA", "length": 766, "header": "tr|E1BGX8-1|E1BGX8_BOVIN Isoform 1 of HHIP like 2 OS=Bos taurus OX=9913 GN=HHIPL2 PE=1 SV=2 CANONICAL=E1BGX8-1" }, "isoforms": [ { "isoform_ac": "E1BGX8-1", "url": "https://www.uniprot.org/uniprotkb/E1BGX8/entry#E1BGX8-1", "sequence": { "sequence": "MLRRSIPRGGWSRWTPWLLTSPRIFCLSLIVLLGQVGLLQGHPQCLDYRPPFQPLQHLEFCSDYESFGCCDQRKDHRIAARYWDIMEYFDLKGHELCGGYIKDILCQECSPYAAHLYDAENPRTPLRNLPGLCSDYCSAFHSNCHSAIALLTNDRRFQESPGKDGTRFCHLLNLPDKDYCFPNILRSDHLNRNLGTVAEDRRGCLQLCLAEVANRLRNPVAMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKSLVLTTPWIGDERGFLGLAFHPRFRRNRKFYIYYSCLGKKRVEKIRISEMKVSRADPNKADPKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGKFGNAQNKSSLLGKVLRIDVNGAGSGGKRYRVPMDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITHQGRGRMFCGDVGENRFEEVDIIVKGGNYGWRAKEGFECYDKKLCQNASLDDILPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKTKKWKKQDICLGSTESCAFPGLISTHSKFIISFGEDEAGELYFLATSYPSAYAPHGSIYKFVDPSRRAPPGKCKYKPVPVKTRSKRVQFRPLAKMVLDLLKEQSEKAARKLSSATLASSPNRASSQKDSFKKPASPTSSRKTSPGPGAKKRARVWSPGPQGKRKGIPKRPSGIARQAAQHRRAGRSLPPPLPSRWPLRGPEPPHHVEAAAEPDFRCAGSRGWRWEPSERA", "length": 766, "header": "tr|E1BGX8-1|E1BGX8_BOVIN Isoform 1 of HHIP like 2 OS=Bos taurus OX=9913 GN=HHIPL2 PE=1 SV=2 CANONICAL=E1BGX8-1" }, "locus": { "chromosome": "16", "start_pos": 26037859, "end_pos": 26010901, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023347.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023347.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023347.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023347.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533766", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533766", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A700-1", "protein_name": "HHIP like 2", "gene_name": "Hhipl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGKHRSPHTVSGRPAQWLSPGIFCLGLTFLLGWVGLLQGHPQCLDYGPPFRPPLHLEFCSDYDSFGCCDRRKDRRIAARYWDIMNYFDLKGHELCGGYIKDILCQECSPYAAHLYDAENPQTPLRNLPGLCSDYCSAFHHNCHSAISLLTNDRGLQESHGKDGARFCHLLNLPDEDYCFPNVLRNDQLNRNLGVVAEDHQGCLQLCLAEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKSMVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLGKRKVEKIRISQMKVSLSDPNKADPKSERVILEIDEPASNHNGGQLLFGLDGYLYIFTGDGGQAGDPFGKFGNAQNKSSLLGKVLRIDVNGAGMSAQRYRVPLDNPFVSEPGAHPAVYAYGVRNMWRCAVDRGDPVTRQGRGRIFCGDVGQNKFEEVDLIVKGGNYGWRAKEGFECYDKNLCHNASLDDILPIYAYGHGVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKTQKWSKRDICLGNSSCAFPGLISAYSKFIISFAEDEAGELYFLATSYPSAYAPHGSIYKFVDPSRRAPPGKCKLKPVPVRAKSKKIRFRPRAATVLDSMKEESQKAAGKPSTSTLASSSDRAAPQRGSPKKPASPPSSKKTFQRPSTKKKSRMWSPGPQGKRKQSQATRKSPGRSHP", "length": 712 }, "evidence": [ { "id": "E1BGX8", "url": "https://omabrowser.org/oma/group/E1BGX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4KFX2-1", "protein_name": "Catalytics", "gene_name": "MYH19.17", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGSLCSIAMFLSFLLLFLAKKSLSHPLCNDLTAPFNLKQPLGFCQFNGSVCCNSLEDLKLQRQFKAFNVSGRCSPLLKSLLCSKCDPFAAELFRVESESRQVPVLCNSTVSSSKSTQSLADIDFCATFWNECQSLSVTNTPFASQAGDGGNITSTISEIWKSSNDFCKIFGGASDESSVCFNGQEVSFNVSKVTGPSSPSGICIEKIGNGSYLNMVPHPDGSNRVFLSDQPGKIYLVTVPAQGSGELLKIDETNPFLDLTEEVHFDAELGLLGIAFHPDFLKNGRFFASFNCDRVKWPECSGKCACNSDIDCDPAKLDSDNGATPCQYHSVISEFFTNGTYVRPVEVRRIFTMGLPFSSHHGGQILFGPKDGYLYFMMGDGGSKGDPYNFAQNKKSLLGKIMRLDVNNVLDAKAMNEFQLWGNYSIPKDNPFSQDKNLLPEIWAMGVRNPWRCSFDSERPSYFLCADVGEDQYEEVDMITKGGNYGWHYYEGTLPFHPSSSSNISNSTTKIENPIFPVMWYNHSDINQQEGSSASITGGYFYRSSTDPCLYGTYLFADLYAGMIFGGAETPVGSGNFTSSHIPLQCASDSPIPCSSETEPSSSSSPPIGFVFSFGEDDNKDIYLLASTGVYRIVGPSRCNFHCSLENTTSSPPSKQPDRSPPSSSFSKKLHNIGTLVVNYLAWCVLLVVI", "length": 690 }, "evidence": [ { "id": "E1BGX8", "url": "https://omabrowser.org/oma/group/E1BGX8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q6UWX4-1", "protein_name": "HHIP-like protein 2", "gene_name": "HHIPL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQCLDYGPPFQPPLHLEFCSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIKDILCQECSPYAAHLYDAENTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYCFPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKKVEKIRISEMKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITRQGRGRIFCGDVGQNRFEEVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDVLPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLCLGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPPGKCKYKPVPVRTKSKRIPFRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGLSEKGSSKKLASPTSSKNTLRGPGTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAGRSLP", "length": 724 }, "evidence": [ { "id": "E1BGX8", "url": "https://omabrowser.org/oma/group/E1BGX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2G9-1", "protein_name": "HHIP-like protein 2", "gene_name": "Hhipl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGKHTSPHTVPGHRAPWLSPGIFCLGLPFLLGWVGLLQGHPQCLDYGPPFRPPQHLDFCSDYDSFGCCDQRKDRRIAARYWDIMSYFDLKAHELCGGYIKDILCQECSPYAAHLYDAENPQTPLRNLPGLCSDYCSAFHRSCHSAISLLTNDRGLQESHGKDGARFCHLLNLPDEDYCFPNVLRNDQLNRNLGVVAEDQQGCLQLCLVEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKSMVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLGKRKVEKIRISEMKVSLSDGNRADPKSERVILEIDEPASNHNGGQLLFGLDGYLYIFTGDGGQAGDPFGKFGNAQNKSSLLGKVLRIDVNGADVDGQRYRVPLDNPFVSEPGAHPAVYAYGVRNMWRCAVDRGDPVTHRGRGRIFCGDVGQNKFEEVDLIVKGGNYGWRAKEGFECYDKRLCRNASLDDILPIYAYGHGVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKTQKWTKRDICLGNSTCAFPGLISAYSRFIISFAEDEAGELYFLATSYPSAYAPHGSIYKFVDPSRRAPPGKCKYKPVPVKTKSKKVRFRPLAATVLDLLKEESQKAARKASNATFTSSSDRVASQKGSLKKPASSRSSKKTFRRPGTKKKSRVWSPRPQGKRKPNLDSHGVGMRQAAGRSHP", "length": 717 }, "evidence": [ { "id": "E1BGX8", "url": "https://omabrowser.org/oma/group/E1BGX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BGX8", "url": "https://www.uniprot.org/uniprotkb/E1BGX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 480, "end_pos": 482, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 766, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGX8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGX8" }, { "id": "PF03024", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Folate receptor-like", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 183, "start_aa": "Gln", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGX8" }, { "id": "PF07995", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07995" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glucose/Sorbosone dehydrogenase", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 543, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 372, "end_pos": 374 }, { "start_pos": 480, "end_pos": 482 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGY1-1", "uniprot_ac": "E1BGY1", "uniprot_id": "E1BGY1_BOVIN", "mass": { "chemical_mass": 100011.0, "monoisotopic_mass": 100011.0 }, "refseq": {}, "gene_names": [ { "name": "FAM111B", "type": "recommended", "evidence": [ { "id": "E1BGY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ] } ], "protein_names": [ { "name": "FAM111 trypsin like peptidase B", "type": "synonym", "evidence": [ { "id": "E1BGY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGY1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM111B", "url": "https://www.uniprot.org/uniprotkb/E1BGY1", "locus": { "chromosome": "15", "start_pos": 82258716, "end_pos": 82242829, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000036016", "url": "https://www.ensembl.org/id/ENSBTAG00000036016" } ] } } ], "crossref": [ { "id": "E1BGY1", "url": "https://alphafold.ebi.ac.uk/entry/E1BGY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000036016", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000036016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509351", "url": "https://www.ncbi.nlm.nih.gov/gene/509351", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LCDIKQK", "url": "https://omabrowser.org/oma/group/LCDIKQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGY1", "url": "https://www.orthodb.org/?gene=E1BGY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14389", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14389", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14389:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14389:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13365", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13365", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26749", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26749", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SXP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGQDGSKPDPEQGRGLWRERWVSREWTGWRRCPHDAPGARLPTREPPRQPGPLPPFLAAALSGSANRLLQGDNFRAGRVSSERRPRNLDRGSLSRHHPHRRGRFSASVSGSSDLEEDVEFLGRRGAVVEESHILLGLIMNFIKTEENTSFSATGNDQSTRPEASKDTVIEEACSGTPVDQSLSDIRERNSTIKVKSEVIEQETSSERQNPHVSTSEKCLFTFSLNERRRKLDHRVFTAFGGPNENIYSVLSADDHFSERMKKHVNKNIIVYEEETIKAYINLGMPLRCLPSGSHLKITFGQRSNEKDDQVLRPCKNPDTECILFHVVAIGKTRKMIVKINELHVQGTTLCVYALKGETIKEALCNDGRFLSNLDTLEWTLRDHKNIYGKQSIVDIVSGKVLELEILKKLSIKKCTHIKIKPEDENATADISLQALTQSKSKAHEPEKDGETEDVEHNREKILPCQSLGLDIKHKTRRSISKIKRYYNNNLYKRLRRKITRVRRRPSLGRLYAILAIQRETTNLWVKNLQILNKVMMHQYPNFNKEALRIQKYFQEERERMKLTTSKQFSMYKHYFGKVTENSVSVAICERLVHLSKSVGFMKWDNNGNTGNATCFVFNDGFIFTCRHVLHLIVGEGTDRKSWPDIISTCVKVTFTYKEFCPNDVDWLSFEPWFMVSGETLDYAILKLSENGNGFPPGLSKLIFRQPSDGLLYLIGHPEGQIKKIDGCSVISLEQRLERYKEHYSDGVVPGSCSDIYNAFPMFTQRSFLSEVWSTNTLSYDTYFSSGSSGSPVFNASGKLVAMHSFGHFYSHVNKAYALIEFGYSMESILCDIKQKDENLYKLLQEEKNESHNEEKDNKQELSLQESQIESMQY", "length": 874, "header": "tr|E1BGY1-1|E1BGY1_BOVIN Isoform 1 of FAM111 trypsin like peptidase B OS=Bos taurus OX=9913 GN=FAM111B PE=4 SV=2 CANONICAL=E1BGY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1/entry#A0AAA9SXP9-1", "sequence": { "sequence": "MPANLENSVVATGLEKDTVIEEACSGTPVDQSLSDIRERNSTIKVKSEVIEQETSSERQNPHVSTSEKCLFTFSLNERRRKLDHRVFTAFGGPNENIYSVLSADDHFSERMKKHVNKNIIVYEEETIKAYINLGMPLRCLPSGSHLKITFGQRSNEKDDQVLRPCKNPDTECILFHVVAIGKTRKMIVKINELHVQGTTLCVYALKGETIKEALCNDGRFLSNLDTLEWTLRDHKNIYGKQSIVDIVSGKVLELEILKKLSIKKCTHIKIKPEDENATADISLQALTQSKSKAHEPEKDGETEDVEHNREKILPCQSLGLDIKHKTRRSISKIKRYYNNNLYKRLRRKITRVRRRPSLGRLYAILAIQRETTNLWVKNLQILNKVMMHQYPNFNKEALRIQKYFQEERERMKLTTSKQFSMYKHYFGKVTENSVSVAICERLVHLSKSVGFMKWDNNGNTGNATCFVFNDGFIFTCRHVLHLIVGEGTDRKSWPDIISTCVKVTFTYKEFCPNDVDWLSFEPWFMVSGETLDYAILKLSENGNGFPPGLSKLIFRQPSDGLLYLIGHPEGQIKKIDGCSVISLEQRLERYKEHYSDGVVPGSCSDIYNAFPMFTQRSFLSEVWSTNTLSYDTYFSSGSSGSPVFNASGKLVAMHSFGHFYSHVNKAYALIEFGYSMESILCDIKQKDENLYKLLQEEKNESHNEEKDNKQELSLQESQIESMQY", "length": 724, "header": "tr|A0AAA9SXP9-1|A0AAA9SXP9_BOVIN Computationally mapped isoform of FAM111 trypsin like peptidase B OS=Bos taurus OX=9913 GN=FAM111B PE=4 SV=1 CANONICAL=E1BGY1-1" }, "locus": { "chromosome": "15", "start_pos": 82257172, "end_pos": 82251724, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116111.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116111.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091250.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091250.1" } ] } }, { "isoform_ac": "A0AAA9TD68-1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1/entry#A0AAA9TD68-1", "sequence": { "sequence": "MRKLRFLKGVSPREGLVDCGGSLLAPGSSSVAVVISSQLNASECSSIRTSLCAVEESHILLGLIMNFIKTEENTSFSATGNDQSTRPEASKDTVIEEACSGTPVDQSLSDIRERNSTIKVKSEVIEQETSSERQNPHVSTSEKCLFTFSLNERRRKLDHRVFTAFGGPNENIYSVLSADDHFSERMKKHVNKNIIVYEEETIKAYINLGMPLRCLPSGSHLKITFGQRSNEKDDQVLRPCKNPDTECILFHVVAIGKTRKMIVKINELHVQGTTLCVYALKGETIKEALCNDGRFLSNLDTLEWTLRDHKNIYGKQSIVDIVSGKVLELEILKKLSIKKCTHIKIKPEDENATADISLQALTQSKSKAHEPEKDGETEDVEHNREKILPCQSLGLDIKHKTRRSISKIKRYYNNNLYKRLRRKITRVRRRPSLGRLYAILAIQRETTNLWVKNLQILNKVMMHQYPNFNKEALRIQKYFQEERERMKLTTSKQFSMYKHYFGKVTENSVSVAICERLVHLSKSVGFMKWDNNGNTGNATCFVFNDGFIFTCRHVLHLIVGEGTDRKSWPDIISTCVKVTFTYKEFCPNDVDWLSFEPWFMVSGETLDYAILKLSENGNGFPPGLSKLIFRQPSDGLLYLIGHPEGQIKKIDGCSVISLEQRLERYKEHYSDGVVPGSCSDIYNAFPMFTQRSFLSEVWSTNTLSYDTYFSSGSSGSPVFNASGKLVAMHSFGHFYSHVNKAYALIEFGYSMESILCDIKQKDENLYKLLQEEKNESHNEEKDNKQELSLQESQIESMQY", "length": 799, "header": "tr|A0AAA9TD68-1|A0AAA9TD68_BOVIN Computationally mapped isoform of FAM111 trypsin like peptidase B OS=Bos taurus OX=9913 GN=FAM111B PE=4 SV=1 CANONICAL=E1BGY1-1" }, "locus": { "chromosome": "15", "start_pos": 82257172, "end_pos": 82243775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088694.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088694.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096057.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096057.1" } ] } }, { "isoform_ac": "A0AAA9TRV3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1/entry#A0AAA9TRV3-1", "sequence": { "sequence": "MPGLLRSNRGGLSVSSPLGEWKDTCGLLVEESHILLGLIMNFIKTEENTSFSATGNDQSTRPEASKDTVIEEACSGTPVDQSLSDIRERNSTIKVKSEVIEQETSSERQNPHVSTSEKCLFTFSLNERRRKLDHRVFTAFGGPNENIYSVLSADDHFSERMKKHVNKNIIVYEEETIKAYINLGMPLRCLPSGSHLKITFGQRSNEKDDQVLRPCKNPDTECILFHVVAIGKTRKMIVKINELHVQGTTLCVYALKGETIKEALCNDGRFLSNLDTLEWTLRDHKNIYGKQSIVDIVSGKVLELEILKKLSIKKCTHIKIKPEDENATADISLQALTQSKSKAHEPEKDGETEDVEHNREKILPCQSLGLDIKHKTRRSISKIKRYYNNNLYKRLRRKITRVRRRPSLGRLYAILAIQRETTNLWVKNLQILNKVMMHQYPNFNKEALRIQKYFQEERERMKLTTSKQFSMYKHYFGKVTENSVSVAICERLVHLSKSVGFMKWDNNGNTGNATCFVFNDGFIFTCRHVLHLIVGEGTDRKSWPDIISTCVKVTFTYKEFCPNDVDWLSFEPWFMVSGETLDYAILKLSENGNGFPPGLSKLIFRQPSDGLLYLIGHPEGQIKKIDGCSVISLEQRLERYKEHYSDGVVPGSCSDIYNAFPMFTQRSFLSEVWSTNTLSYDTYFSSGSSGSPVFNASGKLVAMHSFGHFYSHVNKAYALIEFGYSMESILCDIKQKDENLYKLLQEEKNESHNEEKDNKQELSLQESQIESMQY", "length": 774, "header": "tr|A0AAA9TRV3-1|A0AAA9TRV3_BOVIN Computationally mapped isoform of FAM111 trypsin like peptidase B OS=Bos taurus OX=9913 GN=FAM111B PE=4 SV=1 CANONICAL=E1BGY1-1" }, "locus": { "chromosome": "15", "start_pos": 82257172, "end_pos": 82245719, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135620.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135620.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099765.1" } ] } }, { "isoform_ac": "E1BGY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1/entry#E1BGY1-1", "sequence": { "sequence": "MKGQDGSKPDPEQGRGLWRERWVSREWTGWRRCPHDAPGARLPTREPPRQPGPLPPFLAAALSGSANRLLQGDNFRAGRVSSERRPRNLDRGSLSRHHPHRRGRFSASVSGSSDLEEDVEFLGRRGAVVEESHILLGLIMNFIKTEENTSFSATGNDQSTRPEASKDTVIEEACSGTPVDQSLSDIRERNSTIKVKSEVIEQETSSERQNPHVSTSEKCLFTFSLNERRRKLDHRVFTAFGGPNENIYSVLSADDHFSERMKKHVNKNIIVYEEETIKAYINLGMPLRCLPSGSHLKITFGQRSNEKDDQVLRPCKNPDTECILFHVVAIGKTRKMIVKINELHVQGTTLCVYALKGETIKEALCNDGRFLSNLDTLEWTLRDHKNIYGKQSIVDIVSGKVLELEILKKLSIKKCTHIKIKPEDENATADISLQALTQSKSKAHEPEKDGETEDVEHNREKILPCQSLGLDIKHKTRRSISKIKRYYNNNLYKRLRRKITRVRRRPSLGRLYAILAIQRETTNLWVKNLQILNKVMMHQYPNFNKEALRIQKYFQEERERMKLTTSKQFSMYKHYFGKVTENSVSVAICERLVHLSKSVGFMKWDNNGNTGNATCFVFNDGFIFTCRHVLHLIVGEGTDRKSWPDIISTCVKVTFTYKEFCPNDVDWLSFEPWFMVSGETLDYAILKLSENGNGFPPGLSKLIFRQPSDGLLYLIGHPEGQIKKIDGCSVISLEQRLERYKEHYSDGVVPGSCSDIYNAFPMFTQRSFLSEVWSTNTLSYDTYFSSGSSGSPVFNASGKLVAMHSFGHFYSHVNKAYALIEFGYSMESILCDIKQKDENLYKLLQEEKNESHNEEKDNKQELSLQESQIESMQY", "length": 874, "header": "tr|E1BGY1-1|E1BGY1_BOVIN Isoform 1 of FAM111 trypsin like peptidase B OS=Bos taurus OX=9913 GN=FAM111B PE=4 SV=2 CANONICAL=E1BGY1-1" }, "locus": { "chromosome": "15", "start_pos": 82257172, "end_pos": 82243028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003767.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003767.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003767.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003767.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1RMF9-1", "protein_name": "FAM111 trypsin like peptidase B", "gene_name": "FAM111B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNFMKAEENKSFSTVGNDLSTGPEISKDTTMQQTCSDTPADQLLANLQVSIRTIKIKSEVSEQKISPESQNPHLSTSKKYFTFMLQIGSRKSDQTRKTAHGGLNENIDSALKNNEHFRRHVQDPFKWNIMAYEETTIKGFVNLGMPLRCLPEKSHFKITIVPRKSKQENYDPMLRLCENPDIECILFHVLSIGKNIKKIVKIMDLHEKGSKLCVYAFKGETIKEALCKDGRFRSDLDSLEWELVEGHQNVHGKESTVDQISGKLLEMEVLIKKDKKKGTGTKIKQRNENATDEINHRDSIWSKSTVHEPGPNGETEDTEHNREKILPFQSLESKKHRTISEIKGYYDGSFNTSCMGETSQVRLRSPLPIECAFYTDRQKEATNSWKKNVKILGKAIMHRYPFFNEEVLRVRKYLEEEQKRNLPPFEQFNIYKEYFGKVTENSTSVETCERLIHHSESVGFMKWDVNGNSGSATCFVIKNGYIFTCRHVLDLILRDSTNPSLQLDIISSCVKVTFSYKSFCPKDNDWFSLEKCFAVSDETLDYAILKLSKNGHRFPPGLFQHVSPQPSGGLIYLIGHPEGQIKKIDGCMVIPLEQRLESYPENHRDRVAGTHAPIYNACPVLTQRSFLTEAWSRETLSYDTCFSSGSSGSPVFNASGRLVAMHSFGHFYRHENKVYALIEFGYSMDSILSDIKRKHERLYKLLEEEENENHEEERENTRESSLRDHQVEPMEH", "length": 732 }, "evidence": [ { "id": "E1BGY1", "url": "https://omabrowser.org/oma/group/E1BGY1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6SJ93-1", "protein_name": "Serine protease FAM111B", "gene_name": "FAM111B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSMKTEENKSFSAMEDDQRTRPEVSKDTVMKQTHADTPVDHCLSGIRKCSSTFKLKSEVNKHETALEMQNPNLNNKECCFTFTLNGNSRKLDRSVFTAYGKPSESIYSALSANDYFSERIKNQFNKNIIVYEEKTIDGHINLGMPLKCLPSDSHFKITFGQRKSSKEDGHILRQCENPNMECILFHVVAIGRTRKKIVKINELHEKGSKLCIYALKGETIEGALCKDGRFRSDIGEFEWKLKEGHKKIYGKQSMVDEVSGKVLEMDISKKKALQQKDIHKKIKQNESATDEINHQSLIQSKKKVHKPKKDGETKDVEHSREQILPPQDLSHYIKDKTRQTIPRIRNYYFCSLPRKYRQINSQVRRRPHLGRRYAINLDVQKEAINLLKNYQTLNEAIMHQYPNFKEEAQWVRKYFREEQKRMNLSPAKQFNIYKKDFGKMTANSVSVATCEQLTYYSKSVGFMQWDNNGNTGNATCFVFNGGYIFTCRHVVHLMVGKNTHPSLWPDIISKCAKVTFTYTEFCPTPDNWFSIEPWLKVSNENLDYAILKLKENGNAFPPGLWRQISPQPSTGLIYLIGHPEGQIKKIDGCTVIPLNERLKKYPNDCQDGLVDLYDTTSNVYCMFTQRSFLSEVWNTHTLSYDTCFSDGSSGSPVFNASGKLVALHTFGLFYQRGFNVHALIEFGYSMDSILCDIKKTNESLYKSLNDEKLETYDEEKGKQESSLQDHQIEPMEC", "length": 734 }, "evidence": [ { "id": "E1BGY1", "url": "https://omabrowser.org/oma/group/E1BGY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" }, { "name": "nuclear lamina", "id": "GO:0005652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005652", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" }, { "name": "protein-DNA covalent cross-linking repair", "id": "GO:0106300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106300", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "E1BGY1", "url": "https://www.uniprot.org/uniprotkb/E1BGY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 795, "end_pos": 797, "annotation": "n_glycosylation_sequon" }, { "start_pos": 849, "end_pos": 851, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGY1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 874, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGY1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGY1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 795, "end_pos": 797 }, { "start_pos": 849, "end_pos": 851 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGZ5-1", "uniprot_ac": "E1BGZ5", "uniprot_id": "E1BGZ5_BOVIN", "mass": { "chemical_mass": 66531.0, "monoisotopic_mass": 66531.0 }, "refseq": { "ac": "NP_001359061", "name": "MAGUK p55 subfamily member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061" }, "gene_names": [ { "name": "MPP3", "type": "recommended", "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ] }, { "name": "MPP3", "type": "synonym", "evidence": [ { "id": "NP_001359061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061" } ] } ], "protein_names": [ { "name": "MAGUK p55 subfamily member 3", "type": "recommended", "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5/entry#names_and_taxonomy" } ] }, { "name": "Discs large homolog 3", "type": "synonym", "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5/entry#names_and_taxonomy" } ] }, { "name": "MAGUK p55 subfamily member 3", "type": "synonym", "evidence": [ { "id": "NP_001359061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061" } ] }, { "name": "Protein MPP3", "type": "synonym", "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5/entry#names_and_taxonomy" } ] }, { "name": "membrane palmitoylated protein 3", "type": "synonym", "evidence": [ { "id": "NP_001359061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061" } ] }, { "name": "membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)", "type": "synonym", "evidence": [ { "id": "NP_001359061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061" } ] } ], "function": [ { "annotation": "Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions.", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5#function" }, { "database": "UniProtKB", "id": "ARBA00053289", "url": "https://www.uniprot.org/uniprotkb/ARBA00053289#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPP3", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5", "locus": { "chromosome": "19", "start_pos": 43687136, "end_pos": 43714783, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017536", "url": "https://www.ensembl.org/id/ENSBTAG00000017536" } ] } } ], "crossref": [ { "id": "E1BGZ5", "url": "https://alphafold.ebi.ac.uk/entry/E1BGZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017536", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017536", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06799", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06799", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12039", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12039", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508710", "url": "https://www.ncbi.nlm.nih.gov/gene/508710", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508710", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508710", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MARNKVC", "url": "https://omabrowser.org/oma/group/MARNKVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGZ5", "url": "https://www.orthodb.org/?gene=E1BGZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23122", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23122", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02828", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02828", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001359061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359061", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAMLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGITVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKDSKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLNYRRATGTLPSPQSLKKPPYDEPCDKESCDCEGYFKGYYVAGLRRSFRLGRRERLGSPQEGKTSAVAESPELPTYEEVTRYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAIPHTTRPRKSHEKEGVEYHFVSKQTFEADLHHNKFLEHGEYKENLYGTSLEAIRVVMAKNKVCLVDVEPDALQQLRTSEFKPYVIFVKPAVQEKRKTPPMSPACEDAAAPLDEQQQEMAASASFIDQHYGHLVDAVLVKEDLQSAYSQLRALLERLSKDIHWVPISWVR", "length": 585, "header": "tr|E1BGZ5-1|E1BGZ5_BOVIN Isoform 1 of MAGUK p55 subfamily member 3 OS=Bos taurus OX=9913 GN=MPP3 PE=3 SV=2 CANONICAL=E1BGZ5-1" }, "isoforms": [ { "isoform_ac": "E1BGZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5/entry#E1BGZ5-1", "sequence": { "sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAMLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGITVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKDSKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLNYRRATGTLPSPQSLKKPPYDEPCDKESCDCEGYFKGYYVAGLRRSFRLGRRERLGSPQEGKTSAVAESPELPTYEEVTRYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAIPHTTRPRKSHEKEGVEYHFVSKQTFEADLHHNKFLEHGEYKENLYGTSLEAIRVVMAKNKVCLVDVEPDALQQLRTSEFKPYVIFVKPAVQEKRKTPPMSPACEDAAAPLDEQQQEMAASASFIDQHYGHLVDAVLVKEDLQSAYSQLRALLERLSKDIHWVPISWVR", "length": 585, "header": "tr|E1BGZ5-1|E1BGZ5_BOVIN Isoform 1 of MAGUK p55 subfamily member 3 OS=Bos taurus OX=9913 GN=MPP3 PE=3 SV=2 CANONICAL=E1BGZ5-1" }, "locus": { "chromosome": "19", "start_pos": 43713469, "end_pos": 43688052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023316.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023316.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023316.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023316.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508710", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508710", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S1I8-1", "protein_name": "MAGUK p55 subfamily member 3", "gene_name": "MPP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAMLMVHDTVAQKNFDPVLPPLPDHIAEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGVTVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLSYWRATGTLPSPQSLKKPPYDQPCDKETCDCEGYFKGHYVAGLRRSFRLGRRERLGSPQEGKMSSVAEPLELPTYEEVTRYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFISKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQVVMAKNKVCLVDVEPDALQHLRTSEFKPYVIFVKPAIQEKRKTPPMSPACEDAAAPLDAEQQEMAASAAFIDQHYGHWVDAVLVKEDLQTAHSQLRALLEKLSKDTHWVPISWVR", "length": 585 }, "evidence": [ { "id": "E1BGZ5", "url": "https://omabrowser.org/oma/group/E1BGZ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O88954-1", "protein_name": "MAGUK p55 subfamily member 3", "gene_name": "Mpp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHREEMGFLRDVFSEKSLGYLMKIHEKLRYYERQSPTPVLHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGITVLHKRPDEISQILAQSQGSITLKIIPATQEEDRFKESKVFMRALFHYDPREDRAIPCQEAGLPFQQRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLSYRRTTGTIPSPQNLRKPLYDQPCDKETCDCDGYFKGHYVAGLRRSFRLGCRERLTGSQEVKVPVGAESQVLLTYEEVARYQHQPGERSRLVVLIGSLGAHLHELKQRVVAEDPQHFGVAVPHTTRPRKSHEREGVEYHFVSKQAFEADIQHNKFLEHGEHKENLYGTSLEAIQTVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQEKRKTPPVSPDSEDPATPLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQSVCSQLRAVIESLSKDTYWVPISWVR", "length": 585 }, "evidence": [ { "id": "E1BGZ5", "url": "https://omabrowser.org/oma/group/E1BGZ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13368-1", "protein_name": "MAGUK p55 subfamily member 3", "gene_name": "MPP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR", "length": 585 }, "evidence": [ { "id": "E1BGZ5", "url": "https://omabrowser.org/oma/group/E1BGZ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WFJ8-1", "protein_name": "MAGUK p55 subfamily member 3 isoform X2", "gene_name": "mpp3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKEAMPVLSAGGGLHETLALLTSQLRPDANHKEDMVFLRDVFSERSLSCLMKIHEKLRQYEKQSPTPVLHSASTLAEDVAEELQSGPMSVEEKELLHLLTSPHLKAVLSVHDTVAQKNFDPVLPPLPDDFEDELDEESVKIVRLVKNKEPLGATIRRDESTGAVIVARIMKGGAADRSGLVHVGDELREVNGSSVMHKRPDEISQLLSQSQGSITLKIIPAIKEEDKLQENKVYMRALFDYTPLEDKATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRIGDCNLRAGLVPSKQFQERRLAYRIKMGTLQNSKSPKKAVYDQGCDKEDCDCEGYFNGQYIAGLRRSFRLSRKDRRGSSGEANVSDQNDTDFLTYEEVTRYQQRSNERPRLVVLIGSLGARINELKQKVIAENPHRYAVAVPHTTRPKKSHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKENLYGTSIEAIRSVQAKNKMCLVDVQPEALKALRTAEFKPYVIFVKPKIPESRRRRSAATSPGGGEHGRITEEDLQEMRLSAQQIDQQYGHLVDRVLIKEDTASASTELRSILERLERETFWVPISWVRP", "length": 591 }, "evidence": [ { "id": "E1BGZ5", "url": "https://omabrowser.org/oma/group/E1BGZ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ5", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 585, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGZ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 385, "end_pos": 570, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" }, { "id": "PS51022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "L27", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 60, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 218, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ5" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 226, "end_pos": 296, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BGZ7-1", "uniprot_ac": "E1BGZ7", "uniprot_id": "E1BGZ7_BOVIN", "mass": { "chemical_mass": 88901.0, "monoisotopic_mass": 88901.0 }, "refseq": { "ac": "XP_010810210", "name": "solute carrier family 45 member 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810210" }, "gene_names": [ { "name": "SLC45A4", "type": "recommended", "evidence": [ { "id": "E1BGZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ] }, { "name": "SLC45A4", "type": "synonym", "evidence": [ { "id": "XP_010810210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810210" } ] } ], "protein_names": [ { "name": "Polyamine-transporter SLC45A4", "type": "recommended", "evidence": [ { "id": "E1BGZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 45 member 4", "type": "synonym", "evidence": [ { "id": "E1BGZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 45 member 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010810210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810210" } ] } ], "function": [ { "annotation": "Neuronal polyamine-transporter involved in pain perception. Transports polyamines such as putrescine, cadaverine, spermine and spermidine. Expressed in sensory neuron subtypes within the dorsal root ganglion, where it regulates the excitability of C-polymodal nociceptors by mediating polyamine transport.", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7#function" }, { "database": "UniProtKB", "id": "ARBA00094388", "url": "https://www.uniprot.org/uniprotkb/ARBA00094388#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC45A4", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7", "locus": { "chromosome": "14", "start_pos": 2716565, "end_pos": 2687156, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008597", "url": "https://www.ensembl.org/id/ENSBTAG00000008597" } ] } } ], "crossref": [ { "id": "E1BGZ7", "url": "https://alphafold.ebi.ac.uk/entry/E1BGZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008597", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008597", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520630", "url": "https://www.ncbi.nlm.nih.gov/gene/520630", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520630", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520630", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VPNINGS", "url": "https://omabrowser.org/oma/group/VPNINGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGZ7", "url": "https://www.orthodb.org/?gene=E1BGZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19432", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19432", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19432:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19432:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010810210", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810210", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "35039", "url": "https://www.rhea-db.org/rhea/35039", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72135", "url": "https://www.rhea-db.org/rhea/72135", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMAPQNADAESMQVQELPVPLPDLQKPGRAEAETRDETVSEGSIDRIPVRLWVMHGAVMFGREFCYAMETALVTPVLLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPTRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLSSIEEEQYSPQQERGGDPASAPASGPRACVLDGSVLFPDEVQSEHELALDFLDEGLVRSKSDSVLHVPEAALGLEPELFLQDIEPSIFHDASCPSTPRSTSQEHAPARPPRRPLPLRAPAGEDETLLEEPLSAARLPNGGSAGLRDGPGTCAYSRAALKAPATAGPARRRRHVFRRQASSTFSYYGKIGSHRYRHRRANAVVLIKPSRSMSDLYDLQARPRQHRRRHQSGATTSSGDSESEEGEGETTVRLLWLSMLKMPPELVRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYSAGVKMGCWGLVIYAATGATCSALLQKYLDSYDLSIRVVYVLGTLGFSLGTAVMAMFANVYVAMIMISTMGVVSMSISYCPYALLGQYHDIREYVHHSPGTSKRGFGIDCAILSCQVYISQILVASALGSVVDAVGTVRVIPMVASVGSFLGFLTAAFLVIYPEVSEEAKEEQKGLSSQPLGEGASSSAEKPTMLKLSRKEAPQGLVETESMVFGRSVRSRHILLVLQLLESIFLYDYFRKKNFCLYFPKLWFS", "length": 814, "header": "tr|E1BGZ7-1|E1BGZ7_BOVIN Isoform 1 of Polyamine-transporter SLC45A4 OS=Bos taurus OX=9913 GN=SLC45A4 PE=3 SV=3 CANONICAL=E1BGZ7-1" }, "isoforms": [ { "isoform_ac": "E1BGZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7/entry#E1BGZ7-1", "sequence": { "sequence": "MKMAPQNADAESMQVQELPVPLPDLQKPGRAEAETRDETVSEGSIDRIPVRLWVMHGAVMFGREFCYAMETALVTPVLLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPTRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLSSIEEEQYSPQQERGGDPASAPASGPRACVLDGSVLFPDEVQSEHELALDFLDEGLVRSKSDSVLHVPEAALGLEPELFLQDIEPSIFHDASCPSTPRSTSQEHAPARPPRRPLPLRAPAGEDETLLEEPLSAARLPNGGSAGLRDGPGTCAYSRAALKAPATAGPARRRRHVFRRQASSTFSYYGKIGSHRYRHRRANAVVLIKPSRSMSDLYDLQARPRQHRRRHQSGATTSSGDSESEEGEGETTVRLLWLSMLKMPPELVRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYSAGVKMGCWGLVIYAATGATCSALLQKYLDSYDLSIRVVYVLGTLGFSLGTAVMAMFANVYVAMIMISTMGVVSMSISYCPYALLGQYHDIREYVHHSPGTSKRGFGIDCAILSCQVYISQILVASALGSVVDAVGTVRVIPMVASVGSFLGFLTAAFLVIYPEVSEEAKEEQKGLSSQPLGEGASSSAEKPTMLKLSRKEAPQGLVETESMVFGRSVRSRHILLVLQLLESIFLYDYFRKKNFCLYFPKLWFS", "length": 814, "header": "tr|E1BGZ7-1|E1BGZ7_BOVIN Isoform 1 of Polyamine-transporter SLC45A4 OS=Bos taurus OX=9913 GN=SLC45A4 PE=3 SV=3 CANONICAL=E1BGZ7-1" }, "locus": { "chromosome": "14", "start_pos": 2715561, "end_pos": 2687355, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011341.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011341.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011341.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011341.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520630", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520630", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NU91-1", "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "SLC45A4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVMKMAPQNADSESMQVQDLPVAQLQKPENKENESREETISEGSIDRIPIRLWVMHGAVMFGREFCYAMETALVTPVLLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCIGVLFGVALFLNGSVIGLAIGDVPDKQPIGIVLTVLGVVVLDFCADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYMLGGLDWTQTFLGGIFKSQEQVLFFFAAIIFSVSVALHLFSIEEEQYNPQQDRIDEEGDTLSSVKFSGSLPPLNRLNVISEEEPYGASMFHDEVQSEHDLNMEFLEVNIVRSKSDSVLHMPDATLEIESELLFLHDIEPSIFQDASYPNTPHNTSQEIMKSKLNHLSAFLRDNEKEEEMLLDNHLNEDKVPNMNGSLPKEFLNGHARIGMKQSSTSNSMRRRRHMFYRQPSYTFSYYGKIGSHRYRFRRANAIVLIKSSRSMNDIYDMQKRQRQRYRHRNQSGTTNSSGDTESEEGETETTVRLLWLSMLKMPKELLRLCVCHLLTWFSIIAEAVFYTDFMGQVIFQGDPKAPSNSTELHAYNAGVQMGCWGLVIYAATAAVCSALLQKYLDNYDLSIKVIYILGTLGFSLGTAVMAIFPNVYVTMIMISTMGIVSMSISYCPYALLGQYHDIKEYIHHSPGNSKRGFGIDCAILSCQVYISQILVASALGSVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPEVNEEPKEEQKGLGPPETTEGNSTGAEKPTVLKLTRKGTTTSELEGESAV", "length": 787 }, "evidence": [ { "id": "E1BGZ7", "url": "https://omabrowser.org/oma/group/E1BGZ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ADC6-1", "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "Slc45a4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKMAPQNADSESMQVQELPVPLPDPQKPRDPAAETQEETTSEASIDRIPTRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILVLCVGVLIGVALFLNGSAIGLALGDVPSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGKDPCQAPGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVFFSVSVALHLFSIEEEQYNPQQDRGPEDATLPSTGLQPGAPAPAPRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLDVDIVRSKSDSVLHMADSTLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLRESTKEDDTLLDNHLNEAKVPNGRGSPPMNPLSHSKVDLKPSVTSSSMRRRRHMFHRQSSSTFSYYGKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETETTVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDIKEYVHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDTVNTIVVIPIVASVGSFLGFLTATFLVIYPEVSEEAKEEQKGLSSGAAGEGESGAGTEKPTVLKLSRKGGLRGLMETESMV", "length": 793 }, "evidence": [ { "id": "E1BGZ7", "url": "https://omabrowser.org/oma/group/E1BGZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RSK5-1", "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "SLC45A4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKMAPQNADAESMQVQELPVALPDLKPGGSEAEPRDETISEGSIDRIPVRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGAALFLNGSAIGLSLGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIVFTVSVALHLLSIEEEQYSPQQERSVEAADALAPGLRASVLDGGPLFPDEVQSEHELALDYLDAGLARSKSDSVLHVPDAALDLEPELLFLRDIEPSIFQDASYPSTPRSTSQELARARPPRLPPLRREPAGEDETLLENHLDAAQLPNGGGSPPCDGLVGFSRADVKPPVASGSVRRRRHMFRRQASSTFSYYGKIGSHRYRYRRANAVVLIKPSRSMSDLYDLQKRQRQRCRRRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPKELVRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNSGVKMGCWGLVIYAATGATCSALLQKYLDNYDLSIRVIYVLGTLGFSLGTAVMAMFANVYVAMVMISTMGVVSMSISYCPYALLGQYHDIKEYVQHSPGSSRRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPEVSEEAKEEQKGLSSQPLGEGGSGGGEKPTVLRLSRKEGPQGPVETESMV", "length": 772 }, "evidence": [ { "id": "E1BGZ7", "url": "https://omabrowser.org/oma/group/E1BGZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q0P5V9-1", "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "Slc45a4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMAPQNADSESMQVQELPVPLPDPQKPRDPEAETQEETTSEGSIDRIPTRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLIGVALFLNGSAIGLALGDVPSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGTSVQPGAPAPASRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLDVDIVRSKSDSVLHMADATLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLRESTKEDDTLLDNHLNEAKVPNGRGSPPINSLSRSKVDLKPSVTSGSMRRRRHMFHRQASSTFSYYGKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETETTVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDIKEYVHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVNSIVVIPIVASVGSFLGFLTATFLVIYPEVSEEPKEEQKGLSSGPAGEGEGGAGSEKPTVLKLSRKGGLRGLVETESMV", "length": 785 }, "evidence": [ { "id": "E1BGZ7", "url": "https://omabrowser.org/oma/group/E1BGZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BKX6-1", "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "SLC45A4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFPDEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETESVV", "length": 768 }, "evidence": [ { "id": "E1BGZ7", "url": "https://omabrowser.org/oma/group/E1BGZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sensory perception of pain", "id": "GO:0019233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019233", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "pmid": "" }, { "name": "behavioral response to pain", "id": "GO:0048266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048266", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "sucrose:proton symporter activity", "id": "GO:0008506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008506", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "pmid": "" }, { "name": "polyamine transmembrane transporter activity", "id": "GO:0015203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015203", "evidence": [ { "database": "UniProtKB", "id": "E1BGZ7", "url": "https://www.uniprot.org/uniprotkb/E1BGZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "35039", "name": "", "equation": "spermidine(in) = spermidine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "35039", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35039" } ] }, { "id": "72135", "name": "", "equation": "putrescine(out) = putrescine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72135" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BGZ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BGZ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BGZ7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 553, "end_pos": 555 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BH01-1", "uniprot_ac": "E1BH01", "uniprot_id": "E1BH01_BOVIN", "mass": { "chemical_mass": 31466.0, "monoisotopic_mass": 31466.0 }, "refseq": { "ac": "NP_001179562", "name": "zinc finger protein SNAI3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179562" }, "gene_names": [ { "name": "SNAI3", "type": "recommended", "evidence": [ { "id": "E1BH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ] }, { "name": "SNAI3", "type": "synonym", "evidence": [ { "id": "NP_001179562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179562" } ] } ], "protein_names": [ { "name": "Snail family transcriptional repressor 3", "type": "synonym", "evidence": [ { "id": "E1BH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH01/entry#names_and_taxonomy" } ] }, { "name": "snail homolog 3", "type": "synonym", "evidence": [ { "id": "NP_001179562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179562" } ] }, { "name": "zinc finger protein SNAI3", "type": "synonym", "evidence": [ { "id": "NP_001179562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179562" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAI3", "url": "https://www.uniprot.org/uniprotkb/E1BH01", "locus": { "chromosome": "18", "start_pos": 13913067, "end_pos": 13920768, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017528", "url": "https://www.ensembl.org/id/ENSBTAG00000017528" } ] } } ], "crossref": [ { "id": "E1BH01", "url": "https://alphafold.ebi.ac.uk/entry/E1BH01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017528", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017528", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526694", "url": "https://www.ncbi.nlm.nih.gov/gene/526694", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526694", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526694", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PWDRSSA", "url": "https://omabrowser.org/oma/group/PWDRSSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BH01", "url": "https://www.orthodb.org/?gene=E1BH01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179562", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH01-1", "url": "https://www.uniprot.org/uniprotkb/E1BH01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRSFLVKTHSSHRVPNYGQLETQRDTSGACAACGGLVVPFVLPDKAAPSTSGDPPQPWDFTSVVAHVSLPLPTFLGNEEAGRALGPGPLEVSLEDPRAGRAPSAPLRDSVNHLNLPPLLALPTRWPSILNADGAQAPGCCLPGAERAPCSPGGFPCHRPFHAPAALAGHQQLHCHLQAQRCFTCKFCDKEYGSLGALKMHIRTHTLPCLCAICGKAFSRPWLLQGHLRTHTGEKPYTCPHCSRAFADRSNLRAHLQTHSDTKKYRCKRCAKTFSRMALLARHEEAGCCAP", "length": 291, "header": "tr|E1BH01-1|E1BH01_BOVIN Isoform 1 of Snail family transcriptional repressor 3 OS=Bos taurus OX=9913 GN=SNAI3 PE=3 SV=1 CANONICAL=E1BH01-1" }, "isoforms": [ { "isoform_ac": "E1BH01-1", "url": "https://www.uniprot.org/uniprotkb/E1BH01/entry#E1BH01-1", "sequence": { "sequence": "MPRSFLVKTHSSHRVPNYGQLETQRDTSGACAACGGLVVPFVLPDKAAPSTSGDPPQPWDFTSVVAHVSLPLPTFLGNEEAGRALGPGPLEVSLEDPRAGRAPSAPLRDSVNHLNLPPLLALPTRWPSILNADGAQAPGCCLPGAERAPCSPGGFPCHRPFHAPAALAGHQQLHCHLQAQRCFTCKFCDKEYGSLGALKMHIRTHTLPCLCAICGKAFSRPWLLQGHLRTHTGEKPYTCPHCSRAFADRSNLRAHLQTHSDTKKYRCKRCAKTFSRMALLARHEEAGCCAP", "length": 291, "header": "tr|E1BH01-1|E1BH01_BOVIN Isoform 1 of Snail family transcriptional repressor 3 OS=Bos taurus OX=9913 GN=SNAI3 PE=3 SV=1 CANONICAL=E1BH01-1" }, "locus": { "chromosome": "18", "start_pos": 13919695, "end_pos": 13914071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023305.4", "url": "https://www.ensembl.org/id/ENSBTAT00000023305.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023305.2", "url": "https://www.ensembl.org/id/ENSBTAP00000023305.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526694", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526694", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJ94-1", "protein_name": "Snail family transcriptional repressor 3", "gene_name": "SNAI3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPRSFLVKTHSGHRVPNYGQLETQRETSGSCSACRGLVVPPILPDKAAPSTPSDPPQPRDLTSIVTHALPPPTFLCHEEAQGASGPDPLEVSQAGPRAGRAPCTPLRDSLNPLNLPTRWPPILGADRAQALGCLRGAERAHGALGGCQYHKAFHAASLARRQQLHHHLQAQRCFTCKFCDKDYGSLGALKMHIRTHTLPCLCAICGKAFSRPWLLQGHIRTHTGEKPYTCPHCSRAFADRSNLRAHLHTHSATKRYQCKGCSKTFSRVALLARHEESGCCPGP", "length": 283 }, "evidence": [ { "id": "E1BH01", "url": "https://omabrowser.org/oma/group/E1BH01/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LCD7-1", "protein_name": "Snail family transcriptional repressor 3", "gene_name": "Snai3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTPATVPCNREHERQGQVDGQAPAGSVRDHDAGQPSPVGQTPPTTRRVPGPRTCPGRGFAAPPRRAPRWLAEVVRYANEPDPSRTCRLRCPRAPPDATLGVPPQALDSACSREGTMPRSFLVKTHSSHRVPNYGKLETLREANGSCSACEELVGSCHLPDKEASSNPSDPLQPWDSTSAIACVSLPLLPHHGETLGTSGPEPQETSLVGPRAGQAPSVTLKDSFNLPPVLVLPTRWPPILGSDGALDEHLRAEGTSRVPGSFECIHCHRPYQTLAGLARHQQLHCHLPTGCAFTCRYCDKEYASLGALKMHIRTHTLPCVCKVCGKAFSRPWLLQGHIRTHTGEKPYTCSHCSRAFADRSNLRAHLQTHAGTKKYSSACLLDLFQKGASIGK", "length": 392 }, "evidence": [ { "id": "E1BH01", "url": "https://omabrowser.org/oma/group/E1BH01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3KNW1-1", "protein_name": "Zinc finger protein SNAI3", "gene_name": "SNAI3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRSFLVKTHSSHRVPNYRRLETQREINGACSACGGLVVPLLPRDKEAPSVPGDLPQPWDRSSAVACISLPLLPRIEEALGASGLDALEVSEVDPRASRAAIVPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEKLLGAERMPRAPGGFECFHCHKPYHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALKMHIRTHTLPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCTKTFSRMSLLARHEESGCCPGP", "length": 292 }, "evidence": [ { "id": "E1BH01", "url": "https://omabrowser.org/oma/group/E1BH01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QY31-1", "protein_name": "Zinc finger protein SNAI3", "gene_name": "Snai3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRSFLVKTHSSHRVPNYGKLETLREANGSCSACKELAGSRHLPDEEAPCNPSDPLQPWDSTSAVACISLPLLPNHRETLGVSGPEPQETSWVGPRAAQAPSVTLKDSFTLPPLLVLPTRWPPILGPDGALNEHLRAEGTSRVPGSFECIHCHRPYHTLAGLARHQQLHCHLPTGRAFTCRYCDKEYASLGALKMHIRTHTLPCICKVCGKAFSRPWLLQGHIRTHTGEKPYTCSHCSRAFADRSNLRAHLQTHVGTKKYRCAVCPKAFSRMSLLARHEEAGCCPGP", "length": 287 }, "evidence": [ { "id": "E1BH01", "url": "https://omabrowser.org/oma/group/E1BH01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BH01", "url": "https://www.uniprot.org/uniprotkb/E1BH01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BH01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BH01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BH01" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH01" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 206, "start_aa": "Phe", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BH23-1", "uniprot_ac": "E1BH23", "uniprot_id": "E1BH23_BOVIN", "mass": { "chemical_mass": 17595.0, "monoisotopic_mass": 17595.0 }, "refseq": {}, "gene_names": [ { "name": "RGS21", "type": "recommended", "evidence": [ { "id": "E1BH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling 21", "type": "synonym", "evidence": [ { "id": "E1BH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH23/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS21", "url": "https://www.uniprot.org/uniprotkb/E1BH23", "locus": { "chromosome": "16", "start_pos": 12892342, "end_pos": 12921726, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037494", "url": "https://www.ensembl.org/id/ENSBTAG00000037494" } ] } } ], "crossref": [ { "id": "E1BH23", "url": "https://alphafold.ebi.ac.uk/entry/E1BH23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037494", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037494", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RCCFHRS", "url": "https://omabrowser.org/oma/group/RCCFHRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BH23", "url": "https://www.orthodb.org/?gene=E1BH23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845:SF160", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845:SF160", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH23-1", "url": "https://www.uniprot.org/uniprotkb/E1BH23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVKCCFHRSPTTETVAWSENMDTLLTNQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTESAEKIASKARMIYSEFIEADAPKEINIDFSTRDLISKNIAEPTLKCFDEAQKLIYSLMANDSFPRFLKSEIYKKLVNSKEIGSHKKWLPFL", "length": 152, "header": "tr|E1BH23-1|E1BH23_BOVIN Isoform 1 of Regulator of G protein signaling 21 OS=Bos taurus OX=9913 GN=RGS21 PE=4 SV=2 CANONICAL=E1BH23-1" }, "isoforms": [ { "isoform_ac": "E1BH23-1", "url": "https://www.uniprot.org/uniprotkb/E1BH23/entry#E1BH23-1", "sequence": { "sequence": "MPVKCCFHRSPTTETVAWSENMDTLLTNQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTESAEKIASKARMIYSEFIEADAPKEINIDFSTRDLISKNIAEPTLKCFDEAQKLIYSLMANDSFPRFLKSEIYKKLVNSKEIGSHKKWLPFL", "length": 152, "header": "tr|E1BH23-1|E1BH23_BOVIN Isoform 1 of Regulator of G protein signaling 21 OS=Bos taurus OX=9913 GN=RGS21 PE=4 SV=2 CANONICAL=E1BH23-1" }, "locus": { "chromosome": "16", "start_pos": 12921726, "end_pos": 12893346, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054620.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054620.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050085.2", "url": "https://www.ensembl.org/id/ENSBTAP00000050085.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZN6-1", "protein_name": "Regulator of G-protein signaling 21", "gene_name": "Rgs21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVKCCFYRSPTTETLAWSENMDSLLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTECREKIATKAKMIYSEFIVADAPKEINIDFSTRDLISRNIAEPTPKCFDEAQKLIYSLMAKDSFPRFLKSEIYKKFINTQQVGSHKRWLPFL", "length": 152 }, "evidence": [ { "id": "E1BH23", "url": "https://omabrowser.org/oma/group/E1BH23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2LST8-1", "protein_name": "Regulator of G-protein signaling 21", "gene_name": "Rgs21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVKCCFYRSPTTETLAWSENMDSLLANQAGLDAFRAFLKSEFSEENVEFWLACEDFKKTESREKIATKAKMIYSEFIVADAPKEINIDFSTRDLISRNIDEPTPKCFDEAQKLIYSLMAKDSFPRFLKSEIYKKLVNSQQVANHKRWLPFL", "length": 152 }, "evidence": [ { "id": "E1BH23", "url": "https://omabrowser.org/oma/group/E1BH23/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q2M5E4-1", "protein_name": "Regulator of G protein signaling 21", "gene_name": "RGS21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL", "length": 152 }, "evidence": [ { "id": "E1BH23", "url": "https://omabrowser.org/oma/group/E1BH23/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54S99-1", "protein_name": "RGS domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTQLETIIKDRNLALVFRQFLYNRFNNENFSFWLEVENYKYLDKSEMEVRSKEIFAKYFLADSKYELNLNFQDRKDLEEKINKNSPTSDTFARIQNDIKKHMETDAIPLFLKSDDYKKYKESQTISVPDRDRSVTVGMIEEFFKNRQLETQN", "length": 152 }, "evidence": [ { "id": "E1BH23", "url": "https://omabrowser.org/oma/group/E1BH23/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "V9GXQ3-1", "protein_name": "Regulator of G-protein signalling 21", "gene_name": "Rgs21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVKCCFYRSPTTETLAWSENMDSLLANQAGLDAFRTFLKSEYSEENVEFWLACEDFKKTECREKIATKAKTIYSEFIVADAPKEINIDFSTRDLISRNIAEPTPKCFDEAQKLIYSLMAKDSFPRFLKSEIYKKLVNSQQVGNHKRWLPFL", "length": 152 }, "evidence": [ { "id": "E1BH23", "url": "https://omabrowser.org/oma/group/E1BH23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of G protein-coupled receptor signaling pathway", "id": "GO:0045744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045744", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" }, { "name": "transmission of nerve impulse", "id": "GO:0019226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019226", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" }, { "name": "sensory perception of bitter taste", "id": "GO:0050913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050913", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" }, { "name": "sensory perception of sweet taste", "id": "GO:0050916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050916", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" }, { "name": "sensory perception of umami taste", "id": "GO:0050917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050917", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "E1BH23", "url": "https://www.uniprot.org/uniprotkb/E1BH23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BH23-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BH23-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BH23" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH23" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 137, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BH25-1", "uniprot_ac": "E1BH25", "uniprot_id": "E1BH25_BOVIN", "mass": { "chemical_mass": 172738.0, "monoisotopic_mass": 172738.0 }, "refseq": { "ac": "XP_024852884", "name": "tubby-related protein 4 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852884" }, "gene_names": [ { "name": "TULP4", "type": "recommended", "evidence": [ { "id": "E1BH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH25" } ] }, { "name": "TULP4", "type": "synonym", "evidence": [ { "id": "XP_024852884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852884" } ] } ], "protein_names": [ { "name": "TUB like protein 4", "type": "synonym", "evidence": [ { "id": "E1BH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH25/entry#names_and_taxonomy" } ] }, { "name": "tubby-related protein 4 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024852884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852884" } ] } ], "function": [ { "annotation": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M5W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5W3#function" }, { "database": "UniProtKB", "id": "ARBA00056629", "url": "https://www.uniprot.org/uniprotkb/ARBA00056629#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BH25", "url": "https://www.uniprot.org/uniprotkb/E1BH25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TULP4", "url": "https://www.uniprot.org/uniprotkb/E1BH25", "locus": { "chromosome": "9", "start_pos": 94961851, "end_pos": 94761433, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005083", "url": "https://www.ensembl.org/id/ENSBTAG00000005083" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005083", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005083", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100294795", "url": "https://www.ncbi.nlm.nih.gov/gene/100294795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16517:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16517:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01167", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01167", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852884", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852884", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5W3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH25", "url": "https://www.uniprot.org/uniprotkb/E1BH25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH25-1", "url": "https://www.uniprot.org/uniprotkb/E1BH25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRNTPQRINFNLRGHNSEVQEDPSQSTALTEEVSAYFVLAVHSVIHGFLAAGQMVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSWNYPAFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNSYDDLSPTIIQSGLKEVVAQWCTQGDLLAVAGMERPSQFSDLPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIVSICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASALREDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGSERLHCTMKRTEDDPEVGGPCYTLYLEHLGGLVPILKGRRVSKLRPEFVIMDPRTDSRADEIYGNSLISTMIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLSRAAQELSRSPRLPMRKPSIGSPSLARREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYVNLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGGAEHASESAAQYPVSSQYPVSSRYSNPGQVIFGGVEMGRGLPNPPQLSLPPPAQGTIQLSVLDLGDRDHEHLQKPAKALRPVPQLATEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDTCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPPGDPPPYPDLSGQLGPSRGAGQRPDGGLIHATLRRNNREAALRAAQLAELPRPPPHPPKPKGTAPFPARPPPALYTCSQCSGAGGAAGRPDPGAQPGASLAHAASTSPLTSQSSYNLLGAAEGARERADYVNSAFTEDEALAQHCPADKPPRHPALGEAAVAVKRPPPYQWDPVLGEDVWVPQERTAQSTVPNPLKLPPLVVGPGQHLDVSRVPFVSPKVPASPAATFQPGYGMGVPYSAGCSTSPLPGVQAPCSPKDALAAAQFAQQESTVVLQPAYPPSLAYCTLPPMYPGSSACSSLQLPPIALHPWNSYSPCPPVQNPQGTLPPKAHLVVEKPLVSPPPTDLQSHLGTEVMVETADNFQEVLSLTESPIPQRTEKFGKKNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRAASELEEFKCRKASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK", "length": 1586, "header": "tr|E1BH25-1|E1BH25_BOVIN Isoform 1 of TUB like protein 4 OS=Bos taurus OX=9913 GN=TULP4 PE=3 SV=4 CANONICAL=E1BH25-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5W3-1", "url": "https://www.uniprot.org/uniprotkb/E1BH25/entry#A0A3Q1M5W3-1", "sequence": { "sequence": "MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRNTPQRINFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSWNYPAFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNSYDDLSPTIIQSGLKEVVAQWCTQGDLLAVAGMERPSQFSDLPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIVSICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASALREDKDVNKLTLPPRLCSYLSTAFIPTIKSAPRVRVQGRLVLGDGTDPLVAQPPIPDPNNMRDFVSYPSAGSERLHCTMKRTEDDPEVGGPCYTLYLEHLGGLVPILKGRRVSKLRPEFVIMDPRTDSRADEIYGNSLISTMIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLSRAAQELSRSPRLPMRKPSIGSPSLARREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYVNLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGGAEHASESAAQYPVSSQYPVSSRYSNPGQVIFGGVEMGRGLPNPPQLSLPPPAQGTIQLSVLDLGDRDHEHLQKPAKALRPVPQLATEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDTCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPPGDPPPYPDLSGQLGPSRGAGQRPDGGLIHATLRRNNREAALRAAQLAELPRPPPHPPKPKGTAPFPARPPPALYTCSQCSGAGGAAGRPDPGAQPGASLAHAASTSPLTSQSSYNLLGAAEGARERADYVNSAFTEDEALAQHCPADKPPRHPALGEAAVAVKRPPPYQWDPVLGEDVWVPQERTAQSTVPNPLKLPPLVVGPGQHLDVSRVPFVSPKVPASPAATFQPGYGMGVPYSAGCSTSPLPGVQAPCSPKDALAAAQFAQQESTVVLQPAYPPSLAYCTLPPMYPGSSACSSLQLPPIALHPWNSYSPCPPVQNPQGTLPPKAHLVVEKPLVSPPPTDLQSHLGTEVMVETADNFQEVLSLTESPIPQRTEKFGKKNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRAASELEEFKCRKASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK", "length": 1573, "header": "tr|A0A3Q1M5W3-1|A0A3Q1M5W3_BOVIN Computationally mapped isoform of Tubby-related protein 4 OS=Bos taurus OX=9913 GN=TULP4 PE=3 SV=2 CANONICAL=E1BH25-1" }, "locus": { "chromosome": "9", "start_pos": 94960847, "end_pos": 94820216, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075739.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075739.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065328.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065328.2" } ] } }, { "isoform_ac": "A0AAA9S4A7-1", "url": "https://www.uniprot.org/uniprotkb/E1BH25/entry#A0AAA9S4A7-1", "sequence": { "sequence": "MVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSWNYPAFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNSYDDLSPTIIQSGLKEVVAQWCTQGDLLAVAGMERPSQFSDLPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIVSICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASALREDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGSERLHCTMKRTEDDPEVGGPCYTLYLEHLGGLVPILKGRRVSKLRPEFVIMDPRTDSRADEIYGNSLISTMIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLSRAAQELSRSPRLPMRKPSIGSPSLARREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYVNLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGGAEHASESAAQYPVSSQYPVSSRYSNPGQVIFGGVEMGRGLPNPPQLSLPPPAQGTIQLSVLDLGDRDHEHLQKPAKALRPVPQLATEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDTCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPPGDPPPYPDLSGQLGPSRGAGQRPDGGLIHATLRRNNREAALRAAQLAELPRPPPHPPKPKGTAPFPARPPPALYTCSQCSGAGGAAGRPDPGAQPGASLAHAASTSPLTSQSSYNLLGAAEGARERADYVNSAFTEDEALAQHCPADKPPRHPALGEAAVAVKRPPPYQWDPVLGEDVWVPQERTAQSTVPNPLKLPPLVVGPGQHLDVSRVPFVSPKVPASPAATFQPGYGMGVPYSAGCSTSPLPGVQAPCSPKDALAAAQFAQQESTVVLQPAYPPSLAYCTLPPMYPGSSACSSLQLPPIALHPWNSYSPCPPVQNPQGTLPPKAHLVVEKPLVSPPPTDLQSHLGTEVMVETADNFQEVLSLTESPIPQRTEKFGKKNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRAASELEEFKCRKASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK", "length": 1467, "header": "tr|A0AAA9S4A7-1|A0AAA9S4A7_BOVIN Computationally mapped isoform of TUB like protein 4 OS=Bos taurus OX=9913 GN=TULP4 PE=3 SV=1 CANONICAL=E1BH25-1" }, "locus": { "chromosome": "9", "start_pos": 94960847, "end_pos": 94818293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128874.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128874.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079969.1" } ] } }, { "isoform_ac": "A0AAA9SJ45-1", "url": "https://www.uniprot.org/uniprotkb/E1BH25/entry#A0AAA9SJ45-1", "sequence": { "sequence": "MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRNTPQRINFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSWNYPAFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNSYDDLSPTIIQSGLKEVVAQWCTQGDLLAVAGMERPSQFSDLPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIVSICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASALREDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGSERLHCTMKRTEDDPEVGGPCYTLYLEHLGGLVPILKGRRVSKLRPEFVIMDPRTDSRADEIYGNSLISTMIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLSRAAQELSRSPRLPMRKPSIGSPSLARREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYVNLPVFNPNVFSEDEDDLPGDAVREDR", "length": 679, "header": "tr|A0AAA9SJ45-1|A0AAA9SJ45_BOVIN Computationally mapped isoform of TUB like protein 4 OS=Bos taurus OX=9913 GN=TULP4 PE=4 SV=1 CANONICAL=E1BH25-1" }, "locus": { "chromosome": "9", "start_pos": 94960756, "end_pos": 94820216, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128589.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128589.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085360.1" } ] } }, { "isoform_ac": "E1BH25-1", "url": "https://www.uniprot.org/uniprotkb/E1BH25/entry#E1BH25-1", "sequence": { "sequence": "MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRNTPQRINFNLRGHNSEVQEDPSQSTALTEEVSAYFVLAVHSVIHGFLAAGQMVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSWNYPAFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNSYDDLSPTIIQSGLKEVVAQWCTQGDLLAVAGMERPSQFSDLPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIVSICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASALREDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGSERLHCTMKRTEDDPEVGGPCYTLYLEHLGGLVPILKGRRVSKLRPEFVIMDPRTDSRADEIYGNSLISTMIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLSRAAQELSRSPRLPMRKPSIGSPSLARREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYVNLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGGAEHASESAAQYPVSSQYPVSSRYSNPGQVIFGGVEMGRGLPNPPQLSLPPPAQGTIQLSVLDLGDRDHEHLQKPAKALRPVPQLATEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDTCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPPGDPPPYPDLSGQLGPSRGAGQRPDGGLIHATLRRNNREAALRAAQLAELPRPPPHPPKPKGTAPFPARPPPALYTCSQCSGAGGAAGRPDPGAQPGASLAHAASTSPLTSQSSYNLLGAAEGARERADYVNSAFTEDEALAQHCPADKPPRHPALGEAAVAVKRPPPYQWDPVLGEDVWVPQERTAQSTVPNPLKLPPLVVGPGQHLDVSRVPFVSPKVPASPAATFQPGYGMGVPYSAGCSTSPLPGVQAPCSPKDALAAAQFAQQESTVVLQPAYPPSLAYCTLPPMYPGSSACSSLQLPPIALHPWNSYSPCPPVQNPQGTLPPKAHLVVEKPLVSPPPTDLQSHLGTEVMVETADNFQEVLSLTESPIPQRTEKFGKKNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRAASELEEFKCRKASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK", "length": 1586, "header": "tr|E1BH25-1|E1BH25_BOVIN Isoform 1 of TUB like protein 4 OS=Bos taurus OX=9913 GN=TULP4 PE=3 SV=4 CANONICAL=E1BH25-1" }, "locus": { "chromosome": "9", "start_pos": 94960847, "end_pos": 94820216, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045051.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045051.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042471.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042471.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BH25", "url": "https://www.uniprot.org/uniprotkb/E1BH25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BH25", "url": "https://www.uniprot.org/uniprotkb/E1BH25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1440, "end_pos": 1442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1464, "end_pos": 1466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1580, "end_pos": 1582, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 762, "end_pos": 764, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH25" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 409, "end_pos": 450, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1440, "end_pos": 1442 }, { "start_pos": 1464, "end_pos": 1466 }, { "start_pos": 1580, "end_pos": 1582 }, { "start_pos": 548, "end_pos": 550 }, { "start_pos": 762, "end_pos": 764 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BH53-1", "uniprot_ac": "E1BH53", "uniprot_id": "E1BH53_BOVIN", "mass": { "chemical_mass": 37025.0, "monoisotopic_mass": 37025.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC55", "type": "recommended", "evidence": [ { "id": "E1BH53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 55", "type": "synonym", "evidence": [ { "id": "E1BH53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH53/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC55", "url": "https://www.uniprot.org/uniprotkb/E1BH53", "locus": { "chromosome": "15", "start_pos": 80388634, "end_pos": 80382411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004206", "url": "https://www.ensembl.org/id/ENSBTAG00000004206" } ] } } ], "crossref": [ { "id": "E1BH53", "url": "https://alphafold.ebi.ac.uk/entry/E1BH53", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004206", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004206", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BH53", "url": "https://www.orthodb.org/?gene=E1BH53", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46473", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46473", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46473:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46473:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH53-1", "url": "https://www.uniprot.org/uniprotkb/E1BH53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VLPSPTSQGSSPGSSCPSERLTLDSTARAPVPMGSVQHHCCPQLKMGDAWAHRPWPGPPRPALLLVPLLVAAGVIPSDGGASCPVLCTCHNQAVDCSGQRLFSVPPELPVDTRNLSLAHNRIAAVPPGYLTCYRELRVLSLRNNSLVELPAGLFLHAKRLAHLDLSYNNLSHVPAGMFQAAHSLMRIDLSHNPGLRRVHPLAFQGLAQLRDLDLSFGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI", "length": 343, "header": "tr|E1BH53-1|E1BH53_BOVIN Isoform 1 of Leucine rich repeat containing 55 OS=Bos taurus OX=9913 GN=LRRC55 PE=4 SV=3 CANONICAL=E1BH53-1" }, "isoforms": [ { "isoform_ac": "E1BH53-1", "url": "https://www.uniprot.org/uniprotkb/E1BH53/entry#E1BH53-1", "sequence": { "sequence": "VLPSPTSQGSSPGSSCPSERLTLDSTARAPVPMGSVQHHCCPQLKMGDAWAHRPWPGPPRPALLLVPLLVAAGVIPSDGGASCPVLCTCHNQAVDCSGQRLFSVPPELPVDTRNLSLAHNRIAAVPPGYLTCYRELRVLSLRNNSLVELPAGLFLHAKRLAHLDLSYNNLSHVPAGMFQAAHSLMRIDLSHNPGLRRVHPLAFQGLAQLRDLDLSFGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI", "length": 343, "header": "tr|E1BH53-1|E1BH53_BOVIN Isoform 1 of Leucine rich repeat containing 55 OS=Bos taurus OX=9913 GN=LRRC55 PE=4 SV=3 CANONICAL=E1BH53-1" }, "locus": { "chromosome": "15", "start_pos": 80387630, "end_pos": 80382411, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005510.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005510.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005510.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005510.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ], "pmid": "" }, { "name": "potassium channel activator activity", "id": "GO:0099104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099104", "evidence": [ { "database": "UniProtKB", "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "E1BH53", "url": "https://www.uniprot.org/uniprotkb/E1BH53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BH53-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 343, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BH53-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BH53" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BH53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH53" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 241, "end_pos": 295, "start_aa": "Asn", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BH53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH53" }, { "id": "SM00013", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRNT", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 114, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 143, "end_pos": 145 }, { "start_pos": 169, "end_pos": 171 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BH64-1", "uniprot_ac": "E1BH64", "uniprot_id": "E1BH64_BOVIN", "mass": { "chemical_mass": 61248.0, "monoisotopic_mass": 61248.0 }, "refseq": {}, "gene_names": [ { "name": "GTPBP3", "type": "recommended", "evidence": [ { "id": "E1BH64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ] } ], "protein_names": [ { "name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BH64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH64/entry#names_and_taxonomy" } ] }, { "name": "GTP-binding protein 3", "type": "synonym", "evidence": [ { "id": "E1BH64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH64/entry#names_and_taxonomy" } ] }, { "name": "tRNA modification GTPase GTPBP3, mitochondrial", "type": "synonym", "evidence": [ { "id": "E1BH64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH64/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64#function" }, { "database": "UniProtKB", "id": "ARBA00059757", "url": "https://www.uniprot.org/uniprotkb/ARBA00059757#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTPBP3", "url": "https://www.uniprot.org/uniprotkb/E1BH64", "locus": { "chromosome": "7", "start_pos": 5787558, "end_pos": 5791349, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004200", "url": "https://www.ensembl.org/id/ENSBTAG00000004200" } ] } } ], "crossref": [ { "id": "E1BH64", "url": "https://alphafold.ebi.ac.uk/entry/E1BH64", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004200", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004200", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14858", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14858", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539656", "url": "https://www.ncbi.nlm.nih.gov/gene/539656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFHCHGG", "url": "https://omabrowser.org/oma/group/EFHCHGG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BH64", "url": "https://www.orthodb.org/?gene=E1BH64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42714", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42714", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42714:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42714:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10396", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10396", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12631", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12631", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH64-1", "url": "https://www.uniprot.org/uniprotkb/E1BH64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLEEHHFTAPQRASPRLLSLSLASRSEDLQWMGGTFSTGPNDNRELLSTLPVTPRSGRNLLRGLADPRGRVGRRGADCESMWRGLWTLVSRAARGPHSPRLCTRQGSGYRAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALQSLTAPRDLPLARKACLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCAEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIHAETEAQRRQALRQLDGELGDLCRGWAETLTKALAHVEAYIDFSEDDNLEEGVLDQADSEVRKLEVALGVHLRDARRGQRLRSGAHVVVAGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPALLSDTAGLREGVGPVEQEGVRRAQKRLEQADLILAVLDASDLASPASCNFLDTVVIPAGARNPNGSRQRLLLVLNKSDLLPAGRSDLHPDLPSHLLLSCLTGEGLDGLLEALKKELAALCGDPSTGPLLTRSRHQHHLRGCLDALGQYKQAKDLALAAEALRVARGHLSHLTGGGGTEEILDIIFRDFCVGK", "length": 574, "header": "tr|E1BH64-1|E1BH64_BOVIN Isoform 1 of 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial OS=Bos taurus OX=9913 GN=GTPBP3 PE=3 SV=2 CANONICAL=E1BH64-1" }, "isoforms": [ { "isoform_ac": "E1BH64-1", "url": "https://www.uniprot.org/uniprotkb/E1BH64/entry#E1BH64-1", "sequence": { "sequence": "MLLEEHHFTAPQRASPRLLSLSLASRSEDLQWMGGTFSTGPNDNRELLSTLPVTPRSGRNLLRGLADPRGRVGRRGADCESMWRGLWTLVSRAARGPHSPRLCTRQGSGYRAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALQSLTAPRDLPLARKACLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCAEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIHAETEAQRRQALRQLDGELGDLCRGWAETLTKALAHVEAYIDFSEDDNLEEGVLDQADSEVRKLEVALGVHLRDARRGQRLRSGAHVVVAGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPALLSDTAGLREGVGPVEQEGVRRAQKRLEQADLILAVLDASDLASPASCNFLDTVVIPAGARNPNGSRQRLLLVLNKSDLLPAGRSDLHPDLPSHLLLSCLTGEGLDGLLEALKKELAALCGDPSTGPLLTRSRHQHHLRGCLDALGQYKQAKDLALAAEALRVARGHLSHLTGGGGTEEILDIIFRDFCVGK", "length": 574, "header": "tr|E1BH64-1|E1BH64_BOVIN Isoform 1 of 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial OS=Bos taurus OX=9913 GN=GTPBP3 PE=3 SV=2 CANONICAL=E1BH64-1" }, "locus": { "chromosome": "7", "start_pos": 5791031, "end_pos": 5787972, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005506.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005506.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005506.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005506.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJG8-1", "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "GTPBP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWRVLWTLVARAARGPLSSRPCPRQSSGAPALGPGSTIFALSSGQGRCGIAVIRTSGPASGHALRSLTAPRDLPPARKACLRLLSDPCSGEPLDRALVLWFPGPQSFTGEDCAEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCQGWAETLTRALAHVEAYIDFGEDDNLEEGVLDQADSEVRELEVALGTHLRDARRGQRLRSGAHVVVAGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDVLETPVDLAGFPALLSDTAGLREGVGPVEKEGVRRAQKRLEQADLILAVLDASDLTSSSSCNFLDTVVIPTVAGSPHGSSQRLLLVLNKSDLLPSGGPDLHPDLPPYLLLSCLTGEGLDGLLEALRKELATLCGDPSTGPPLLTRARHQHHLQGCLDALGHYKQAKDLALAAEALRVARGHLARLTGRGGTEEILDIIFRDFCVGK", "length": 494 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P32559-1", "protein_name": "tRNA modification GTPase MSS1, mitochondrial", "gene_name": "MSS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNSASFLQSRLISRSFLVRRSLKRYSGLAKPYTFQQPTIYALSTPANQTSAIAIIRISGTHAKYIYNRLVDSSTVPPIRKAILRNIYSPSSCSVKPHDQKESKILLDTSLLLYFQAPYSFTGEDVLELHVHGGKAVVNSILKAIGSLHDRSSGKDIRFALPGDFSRRAFQNGKFDLTQLEGIKDLIDSETESQRRSALSSFNGDNKILFENWRETIIENMAQLTAIIDFADDNSQEIQNTDEIFHNVEKNIICLRDQIVTFMQKVEKSTILQNGIKLVLLGAPNVGKSSLVNSLTNDDISIVSDIPGTTRDSIDAMINVNGYKVIICDTAGIREKSSDKIEMLGIDRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFGNKRIIIVVNKSDLVSDDEMTKVLNKLQTRLGSKYPILSVSCKTKEGIESLISTLTSNFESLSQSSADASPVIVSKRVSEILKNDVLYGLEEFFKSKDFHNDIVLATENLRYASDGIAKITGQAIGIEEILDSVFSKFCIGK", "length": 526 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55C52-1", "protein_name": "tRNA modification GTPase gtpbp3, mitochondrial", "gene_name": "gtpbp3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKRLFCSINKNKIINEPPKLSIIKDTIYNLSSGVGKSGVAIIRVSGPQAETVIRKLIKKSDVDKNEEIKSRYATLSTFYNPKTNEQLDKGMFIWFPSPNSFTGEDVVEFHIHGGRAVIYETMEAIGLIEGTRPSEQGEFTKRAFENGKMDLTQVEGLSDLLDASTSFQKKIALKQMQGSISEFYLSLRKDLIRASAYMEAFIDFGDDAELDPEIVDQSRNRIISIRDKIQQHLNDGKRGERLRDGANIAIVGPPNAGKSSLINLLTNRKASIVSPIAGTTRDIVEVILDIDGYPVIIGDTAGLRNSTNDQIEIEGIEMAKDRFNNSDIKLFLFDSFNLFSQLNQNQNLNSSFNFNEEIKNLFNFIDNETIIIFNKSDLLKQFDNLKEWENLKLNLLDNIKKSNNLNSIQSIEISCNNNENIKDLLNLLKLNLKNLFEIQDKESPLLTRLRYKQHLSDCVESLDRYLYYCEHDVVLASEELRSAILSISEITHSVNIDDLLDIIFKDFCIGK", "length": 512 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5PQQ1-1", "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "Gtpbp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWRGLSALVTRPASAPLRLCARCSTGAESLVPGSTIFALSSGQGRCAIAVIRTSGPASGLALRSLTALREPPPARSACLRLLRHPCSGEPLDRSLVLWFPGPQSFTGEDCMELHVHGGPAVVSGVLQALGSVPGLRPAKAGEFTRRAFAHGKLSLTEVEGLADLIHAETEAQRRQALRQLDGELSQLCQGWAKTLTKALAHVEAYIDFGEDDNLEEGVLEQVDRDVRALEVALSSHLRDARRGQRLRSGANVVVAGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDILETPVDLAGFPVLLSDTAGLREGAGAVEQEGVRRARQRLEQADIILGMLDASDLASSSSCSFLDTVVAPLVAQSHDSGRQRLLLLLNKSDLLSANAPASSTALPPHLLLSCHTGAGMDALLQALKTELAAVCGDPSTGPPLLTRARHQYHLQGCLDALGRFQLTTDLALAAEALRQARRQLSHLTGGGGTEEILDLIFQDFCVGK", "length": 492 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q923K4-1", "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "Gtpbp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRGLSALVTQAAWAPLRLCARCSTSAESLVPSSTIFALSSGQGRCAIAVIRTSGPASGLALRSLTALQEPPPARRACLRLLRHPCSGEPLDRSLVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIRAETEAQRRQALRQLDGELSQLCQGWAKTLTKALAYVEAYIDFGEDDNLEEGVLEQADREVRALEVALGSHLRDARRGQRLLSGANVVVTGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGAVEQEGVRRARHRLEQADIILGVLDASDLASSSSCSFLDTVVTPLLAQSQDSGGQRLLLLLNKSDLLSANAPACDIALPPHLLLSCHTGAGMDSLLQALKTELAAVCGDPSTGPPLLTRVRHQYHLQGCLDALGHYQLATDLALAAEALRQARRQLNHLTGGGGTEEILDLIFQDFCVGK", "length": 492 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969Y2-1", "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "GTPBP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALQVALGAHLRDARRGQRLRSGVHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEILDIIFQDFCVGK", "length": 492 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VC87-1", "protein_name": "tRNA modification GTPase GTPBP3, mitochondrial", "gene_name": "Dmel\\CG18528", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MALLRNASQSFLGSFRRFASSGCTIYSLSSGHVKCGVSVIRVSGPQTKKALRAIVANKEYEPKARQAYLKSFYHPASKEMIDRGLLLWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALGKVDGLRPAEPGEFTKRAFFGGKLDLTEVEGLADLIHAETEAQRKQALLQSTGALARLYDNWRRRLIRCAAHLEAYIDFAEEEQIEGGIILQLGKELKAVKREIREHLSDQRQGELLRDGVRTVIIGAPNVGKSSLLNLLCQRSVSIVTDQAGTTRDIIETMHNFGGYPVVFSDTAGLRRYTTDSIEQEGMQRAKNCLVQSDLILLLAEAKNIAQLTHDDAVAPFVDSYLGELDIPLDMCSGKRLQLVANKTDTLTDEEHQQLDKLSNVLAISCHKPDKMPVFLGSLEKQLQELCGEPRAENPRITNTRYRQQLERCIENIDIFLRDYRPDVYPDMAIAASKLRNSVRCIERITGHISCEDILDVVFKDFCIGK", "length": 493 }, "evidence": [ { "id": "E1BH64", "url": "https://omabrowser.org/oma/group/E1BH64/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "tRNA 5-taurinomethyluridine synthase activity", "id": "GO:0160236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160236", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "GTPBP3-MTO1 complex", "id": "GO:7770010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:7770010", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" }, { "name": "mitochondrial tRNA wobble uridine modification", "id": "GO:0070899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070899", "evidence": [ { "database": "UniProtKB", "id": "E1BH64", "url": "https://www.uniprot.org/uniprotkb/E1BH64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BH64-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 574, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BH64-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BH64" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BH64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH64" }, { "id": "PS51709", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51709" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TrmE-type G", "eco_id": "ECO_0000259", "start_pos": 332, "end_pos": 499, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 446, "end_pos": 448 }, { "start_pos": 457, "end_pos": 459 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHA0-1", "uniprot_ac": "E1BHA0", "uniprot_id": "E1BHA0_BOVIN", "mass": { "chemical_mass": 66586.0, "monoisotopic_mass": 66586.0 }, "refseq": { "ac": "NP_001179216", "name": "leucine zipper putative tumor suppressor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179216" }, "gene_names": [ { "name": "LZTS1", "type": "recommended", "evidence": [ { "id": "E1BHA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ] }, { "name": "LZTS1", "type": "synonym", "evidence": [ { "id": "NP_001179216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179216" } ] } ], "protein_names": [ { "name": "Leucine zipper tumor suppressor 1", "type": "synonym", "evidence": [ { "id": "E1BHA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA0/entry#names_and_taxonomy" } ] }, { "name": "leucine zipper putative tumor suppressor 1", "type": "synonym", "evidence": [ { "id": "NP_001179216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179216" } ] }, { "name": "leucine zipper, putative tumor suppressor 1", "type": "synonym", "evidence": [ { "id": "NP_001179216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179216" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LZTS1", "url": "https://www.uniprot.org/uniprotkb/E1BHA0", "locus": { "chromosome": "8", "start_pos": 67361738, "end_pos": 67371555, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000841", "url": "https://www.ensembl.org/id/ENSBTAG00000000841" } ] } } ], "crossref": [ { "id": "E1BHA0", "url": "https://alphafold.ebi.ac.uk/entry/E1BHA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000841", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000841", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539634", "url": "https://www.ncbi.nlm.nih.gov/gene/539634", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR045329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539634", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539634", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QKTRGSH", "url": "https://omabrowser.org/oma/group/QKTRGSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHA0", "url": "https://www.orthodb.org/?gene=E1BHA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19354", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19354", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19354:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19354:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06818", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06818", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG59", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG59-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BHA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSVSSLISGHGFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESAGHQLHPAPLDKPKEQELKPSLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPASRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLAHASKDKGSVRSPISTDQCTIQELEKQLLEREGELQRLHRSFEEKELAASQPYEERPRRCKDELEGLEAKGKMKVAAQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEKEKTSFAPALEETQWEVCQKSGEISLLKQQLKESQTEINAKASEILNLKAQLKDTRGRLESLELKTQDLENALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALQRSRDAAALGPASADDVPALQRELERLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDGAGEPFEIDLEGADIPYEDIIATEI", "length": 595, "header": "tr|E1BHA0-1|E1BHA0_BOVIN Isoform 1 of Leucine zipper tumor suppressor 1 OS=Bos taurus OX=9913 GN=LZTS1 PE=4 SV=3 CANONICAL=E1BHA0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MG59-1", "url": "https://www.uniprot.org/uniprotkb/E1BHA0/entry#A0A3Q1MG59-1", "sequence": { "sequence": "MGSVSSLISGHGFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESAGHQLHPAPLDKPKEQELKPSLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPASRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLAHASKDKGSVRSPISTDQCTIQELEKQLLEREGELQRLHRSFEEKELAASQPYEERPRRCKDELEGLEAKGKMKVAAQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEKEKTSFAPALEETQWEVCQKSGEISLLKQQLKESQTEINAKASEILNLKAQLKDTRGRLESLELKTQDLENALRTKGLELEVCENELQRKKNEAELLREKHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDGAGEPFEIDLEGADIPYEDIIATEI", "length": 532, "header": "tr|A0A3Q1MG59-1|A0A3Q1MG59_BOVIN Computationally mapped isoform of Leucine zipper tumor suppressor 1 OS=Bos taurus OX=9913 GN=LZTS1 PE=4 SV=1 CANONICAL=E1BHA0-1" }, "locus": { "chromosome": "8", "start_pos": 67371420, "end_pos": 67364869, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084519.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084519.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067976.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067976.2" } ] } }, { "isoform_ac": "E1BHA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BHA0/entry#E1BHA0-1", "sequence": { "sequence": "MGSVSSLISGHGFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESAGHQLHPAPLDKPKEQELKPSLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPASRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLAHASKDKGSVRSPISTDQCTIQELEKQLLEREGELQRLHRSFEEKELAASQPYEERPRRCKDELEGLEAKGKMKVAAQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEKEKTSFAPALEETQWEVCQKSGEISLLKQQLKESQTEINAKASEILNLKAQLKDTRGRLESLELKTQDLENALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALQRSRDAAALGPASADDVPALQRELERLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDGAGEPFEIDLEGADIPYEDIIATEI", "length": 595, "header": "tr|E1BHA0-1|E1BHA0_BOVIN Isoform 1 of Leucine zipper tumor suppressor 1 OS=Bos taurus OX=9913 GN=LZTS1 PE=4 SV=3 CANONICAL=E1BHA0-1" }, "locus": { "chromosome": "8", "start_pos": 67371420, "end_pos": 67364869, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001114.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001114.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001114.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001114.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539634", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539634", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z9W7-1", "protein_name": "Leucine zipper tumor suppressor 1", "gene_name": "LZTS1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQESGHKSGSKSSKNEDFFYIKVSQKAPGPHRTDYTALGSTELGQAGSSGVDFGTPTPQKLMPFPSQLEVGVEKPMARPTAFKPVLPRSGAVLHSSPENGAHLPTQLHPLDKGKEQELKPVLCSGGLSDSGRNSMSSLPTHSTSSSYQLDPIVTPVGPISRFGGSAHNIMQCAIIQDSNMMSLKAMSFSDGGNKILNPGKAPQHRAAEKTACIRSPISTDESTIQELEQKLLEREGELQELQLSFEEKEASSCQVYEEKQRRCKEELEGLKQRCNSKLKQSSQKTQRTQQVLQLQVFQLQQEKQQLREELENLMKEQNLLETKLRSYEKEKTSFAPALEETQWEVCQKSGEISLLKQQLKESQTELTTKTTEILSLKAQLKDVRAKMEGLEMKTQDLEGSLRTKAMELEVCENELQRKKNESELLREKVNLLEQEIVELRAEMAVLRAQLSDATRPSEVQALQGEVERLRAELQAERDSNEQMSSSFQQERQTWREEKEKVIHYQKQLQQSYLHMYKRNQNLEKMLQQLAAGEDGKEPIELDIPGADVPYEDIIATEI", "length": 604 }, "evidence": [ { "id": "E1BHA0", "url": "https://omabrowser.org/oma/group/E1BHA0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H6W2-1", "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "Lzts1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLKFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDMGGQAGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKVDKGSSCVRSPLSTDECTIQELEQKLLQRESALQKLQRSFDEKEFVSGQTFEERPRRTRDELECLEPKSKLKPASQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQIEVNTKASEILSLKAQLKDTRGKLESMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALHREATSLGPLGVGPTFSEDIPALQRELERLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDGAVEPFEIDLEGADIPYEDIIATEI", "length": 601 }, "evidence": [ { "id": "E1BHA0", "url": "https://omabrowser.org/oma/group/E1BHA0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P60853-1", "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "Lzts1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDIGGQTGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESTSHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKADKGASCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPPSQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELMELRAQAALHPAPLGPPGVGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQRQLQQSYLAMYQRNQRLEKALQQLARGDGPGEPFEIDLEGADIPYEDIIATEI", "length": 599 }, "evidence": [ { "id": "E1BHA0", "url": "https://omabrowser.org/oma/group/E1BHA0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CFC9-1", "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "Lzts1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSVSSLISGHSLHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDMGGQTGVDFDPATPPKLMPFSSQLEMSSDKAAVRPTAFKPVLPRSGAILHSSPESTNHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKVEKGSSCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPASQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQMEVNAKASEILSLKAQLKDTRGKLEGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALHRDAAPLGPPGIGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDIAGEPFEIDLEGADIPYEDIIATEI", "length": 601 }, "evidence": [ { "id": "E1BHA0", "url": "https://omabrowser.org/oma/group/E1BHA0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y250-1", "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "LZTS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI", "length": 596 }, "evidence": [ { "id": "E1BHA0", "url": "https://omabrowser.org/oma/group/E1BHA0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of dendrite morphogenesis", "id": "GO:0048814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048814", "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "pmid": "" }, { "name": "negative regulation of macroautophagy", "id": "GO:0016242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016242", "evidence": [ { "database": "UniProtKB", "id": "E1BHA0", "url": "https://www.uniprot.org/uniprotkb/E1BHA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHA0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 595, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHA0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHA0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHB7-1", "uniprot_ac": "E1BHB7", "uniprot_id": "E1BHB7_BOVIN", "mass": { "chemical_mass": 33809.0, "monoisotopic_mass": 33809.0 }, "refseq": { "ac": "XP_005211499", "name": "E3 ubiquitin-protein ligase RNF212B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211499" }, "gene_names": [ { "name": "RNF212B", "type": "recommended", "evidence": [ { "id": "E1BHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ] }, { "name": "RNF212B", "type": "synonym", "evidence": [ { "id": "XP_005211499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211499" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RNF212B", "type": "synonym", "evidence": [ { "id": "XP_005211499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211499" } ] }, { "name": "Ring finger protein 212B", "type": "synonym", "evidence": [ { "id": "E1BHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHB7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF212B", "url": "https://www.uniprot.org/uniprotkb/E1BHB7", "locus": { "chromosome": "10", "start_pos": 21613371, "end_pos": 21659773, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025755", "url": "https://www.ensembl.org/id/ENSBTAG00000025755" } ] } } ], "crossref": [ { "id": "E1BHB7", "url": "https://alphafold.ebi.ac.uk/entry/E1BHB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025755", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025755", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101905955", "url": "https://www.ncbi.nlm.nih.gov/gene/101905955", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QVWRFQK", "url": "https://omabrowser.org/oma/group/QVWRFQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHB7", "url": "https://www.orthodb.org/?gene=E1BHB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22663:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22663:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005211499", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211499", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWFHCNRCFRKDGAHFFVTNCGHIFCKKCVILEKCAVCGTACKYLALSDNLKPQEKMYFRNPVETALQYFSHISQVWSFQKKQTDLLIAFYKHRITELEAAMQESQQTLTNQDKELSVLRKENGELKKFQAIMKESPSWYQGSRLNTPRPVGITSPSQSVTPRPISQHSSQVVSRSSSVESTPYRMAGFSNLGQGARGLQGRSTPRDSFTVTPSPASTHSLSYRASSASSGQGVFAFRPSLNSGDLGHTRVFTPNNPGQRQNRTTLESLPSFQLPVLQNLYQQRQMGLARGREAWNTPR", "length": 300, "header": "tr|E1BHB7-1|E1BHB7_BOVIN Isoform 1 of Ring finger protein 212B OS=Bos taurus OX=9913 GN=RNF212B PE=4 SV=1 CANONICAL=E1BHB7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0X5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHB7/entry#A0A3Q1M0X5-1", "sequence": { "sequence": "MDWFHCNRCFRKDGAHFFVTNCGHIFCKKCVILEKCAVCGTACKYLALSDNLKPQEKMYFRNPVETALQYFSHISQVWSFQKKQTDLLIAFYKHRITELEAAMQESQQTLTNQDKELSVLRKENGELKKFQAIMKESPSWYQGSRLNTPRPVGITSPSQSVTPRPISQHSSQVVSRSSSVESTPYRMAGFSNLGQGARGLQGRSTPRDSFTVTPSPASTHSLSYRASSASSGQGVFAFRPSLNSGDLGHTRVFTPNNPGQRQNRTTLESLPSFQLPVLQPPTQSWMITSSSSSSSSSSSSSSPSSGSSSSSSSSSSSRQTTTSAGSGSISCVLQTTKNLDLSLGMKWIWNCFFSLLGDCQEGA", "length": 363, "header": "tr|A0A3Q1M0X5-1|A0A3Q1M0X5_BOVIN Computationally mapped isoform of Ring finger protein 212B OS=Bos taurus OX=9913 GN=RNF212B PE=4 SV=1 CANONICAL=E1BHB7-1" }, "locus": { "chromosome": "10", "start_pos": 21658027, "end_pos": 21613502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075915.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075915.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066892.2" } ] } }, { "isoform_ac": "E1BHB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHB7/entry#E1BHB7-1", "sequence": { "sequence": "MDWFHCNRCFRKDGAHFFVTNCGHIFCKKCVILEKCAVCGTACKYLALSDNLKPQEKMYFRNPVETALQYFSHISQVWSFQKKQTDLLIAFYKHRITELEAAMQESQQTLTNQDKELSVLRKENGELKKFQAIMKESPSWYQGSRLNTPRPVGITSPSQSVTPRPISQHSSQVVSRSSSVESTPYRMAGFSNLGQGARGLQGRSTPRDSFTVTPSPASTHSLSYRASSASSGQGVFAFRPSLNSGDLGHTRVFTPNNPGQRQNRTTLESLPSFQLPVLQNLYQQRQMGLARGREAWNTPR", "length": 300, "header": "tr|E1BHB7-1|E1BHB7_BOVIN Isoform 1 of Ring finger protein 212B OS=Bos taurus OX=9913 GN=RNF212B PE=4 SV=1 CANONICAL=E1BHB7-1" }, "locus": { "chromosome": "10", "start_pos": 21658027, "end_pos": 21629671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036401.3", "url": "https://www.ensembl.org/id/ENSBTAT00000036401.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036259.1", "url": "https://www.ensembl.org/id/ENSBTAP00000036259.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 213, "start_aa": "Thr", "end_pos": 213, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr213", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:101905955", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905955", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GKF5-1", "protein_name": "Ring finger protein 212B", "gene_name": "Rnf212b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCMTLEKCGVCGRPCKHLALSDNLKPQEKKFFKSPVETAVQCFSHVAQVWCFQKKQTDLLIAFYKDRIRNLEAAVKEAQETAASQNKELSVLRKENGELKKILAILKGSPSCYYGNRLTTPRPVGITSPSQSAAPRPSSQHSSQVVSRSSSMESIPYTVAGISHVEQGSRGLHERSAPRDSYTETPSPASTHSLSYRPSSASSGQGVSFRPFFSGDSGHTRVLTPNNSGQRESRTTPENLPGFQLPVLQTFYQHRQMGLARRDGWSVSR", "length": 297 }, "evidence": [ { "id": "E1BHB7", "url": "https://omabrowser.org/oma/group/E1BHB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8MTL3-1", "protein_name": "E3 ubiquitin-protein ligase RNF212B", "gene_name": "RNF212B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCVTLEKCAVCGTACKHLALSDNLKPQEKMFFKSPVETALQYFSHISQVWSFQKKQTDLLIAFYKHRITKLETAMQEAQQALVSQDKELSVLRKENGELKKFLAILKESPSRYQGSRSITPRPVGITSPSQSVTPRPSFQHSSQVVSRSSSAESIPYREAGFGSLGQGGRGLQGRRTPRDSYNETPSPASTHSLSYRTSSASSGQGIFSFRPSPNGHSGHTRVLTPNNFAQRESTTTLESLPSFQLPVLQTLYQQRRHMGLPSGREAWTTSR", "length": 300 }, "evidence": [ { "id": "E1BHB7", "url": "https://omabrowser.org/oma/group/E1BHB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3Z423-1", "protein_name": "E3 ubiquitin-protein ligase RNF212B", "gene_name": "Rnf212b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCMTLEKCAVCGNLCKHLALSDNLKPQEKKFFKSPVETALQCFSHISQVWCFQKKQTDLLIAFYKDRITKLEAAVKEAQEMAASQNKELSALRKENGELKKILDILKGSPSCYYGSRLTTPRPVGITSPSQSVAPRPSSHHSSQVVSRSSSMESIPYTVAGMGHVEQGSRGLHVRSTPGDSYTETPSPASTHSLSYRPSSASSGQGVSFRPFFSGDSGHTRVLTPNNSGRRESRTTPESLPGFQLPVLQTFYQQRQMGLARKDGWNISR", "length": 297 }, "evidence": [ { "id": "E1BHB7", "url": "https://omabrowser.org/oma/group/E1BHB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" }, { "name": "SUMO transferase activity", "id": "GO:0019789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" }, { "name": "chiasma assembly", "id": "GO:0051026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051026", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "synaptonemal complex", "id": "GO:0000795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000795", "evidence": [ { "database": "UniProtKB", "id": "E1BHB7", "url": "https://www.uniprot.org/uniprotkb/E1BHB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHB7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 300, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHB7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHB7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 213 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 263, "end_pos": 265 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHC4-1", "uniprot_ac": "E1BHC4", "uniprot_id": "E1BHC4_BOVIN", "mass": { "chemical_mass": 35384.0, "monoisotopic_mass": 35384.0 }, "refseq": { "ac": "NP_001377529", "name": "olfactory receptor family 51 subfamily H member 5", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529" }, "gene_names": [ { "name": "OR51H5", "type": "recommended", "evidence": [ { "id": "E1BHC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ] }, { "name": "OR51H5", "type": "synonym", "evidence": [ { "id": "NP_001377529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 51 subfamily H member 5", "type": "synonym", "evidence": [ { "id": "E1BHC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHC4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily H member 5", "type": "synonym", "evidence": [ { "id": "NP_001377529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529" } ] }, { "name": "putative olfactory receptor 51H1", "type": "synonym", "evidence": [ { "id": "NP_001377529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51H5", "url": "https://www.uniprot.org/uniprotkb/E1BHC4", "locus": { "chromosome": "15", "start_pos": 50114052, "end_pos": 50115008, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067027", "url": "https://www.ensembl.org/id/ENSBTAG00000067027" } ] } } ], "crossref": [ { "id": "E1BHC4", "url": "https://alphafold.ebi.ac.uk/entry/E1BHC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788864", "url": "https://www.ncbi.nlm.nih.gov/gene/788864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788864", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788864", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IWTRAIC", "url": "https://omabrowser.org/oma/group/IWTRAIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHC4", "url": "https://www.orthodb.org/?gene=E1BHC4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADNNHSHFQHLYFVLTGIPGLELKYYWMAFPLGAIYVIALFGNGVIISTIKSELSLHIPMYYFLCMLALADTGLALCTMPSMLGIFWFNYKSIAFDACLVQMYFIHTFSAIESGVLVAMAFDRVVAIWKPLRYGTILTNSVVCRTGAVIWTRAICVVFPVPFLIKRLPFYRSNVLSHSFCLHQDVMSLACASTQVNSLYGLIAVIFTKGSDSLSILLSYAFLLRTVMAIASGEGRLKALNTCVSHICAVLIFYVPLIGVSVIHRFGKHVSPLTHALMANAYLLIPPVLNPIVYTMKTKEIRRKLIQMFVAAKVTAEG", "length": 318, "header": "tr|E1BHC4-1|E1BHC4_BOVIN Isoform 1 of Olfactory receptor family 51 subfamily H member 5 OS=Bos taurus OX=9913 GN=OR51H5 PE=3 SV=1 CANONICAL=E1BHC4-1" }, "isoforms": [ { "isoform_ac": "E1BHC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHC4/entry#E1BHC4-1", "sequence": { "sequence": "MADNNHSHFQHLYFVLTGIPGLELKYYWMAFPLGAIYVIALFGNGVIISTIKSELSLHIPMYYFLCMLALADTGLALCTMPSMLGIFWFNYKSIAFDACLVQMYFIHTFSAIESGVLVAMAFDRVVAIWKPLRYGTILTNSVVCRTGAVIWTRAICVVFPVPFLIKRLPFYRSNVLSHSFCLHQDVMSLACASTQVNSLYGLIAVIFTKGSDSLSILLSYAFLLRTVMAIASGEGRLKALNTCVSHICAVLIFYVPLIGVSVIHRFGKHVSPLTHALMANAYLLIPPVLNPIVYTMKTKEIRRKLIQMFVAAKVTAEG", "length": 318, "header": "tr|E1BHC4-1|E1BHC4_BOVIN Isoform 1 of Olfactory receptor family 51 subfamily H member 5 OS=Bos taurus OX=9913 GN=OR51H5 PE=3 SV=1 CANONICAL=E1BHC4-1" }, "locus": { "chromosome": "15", "start_pos": 50115008, "end_pos": 50114055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055997.2", "url": "https://www.ensembl.org/id/ENSBTAT00000055997.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000050524.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788864", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788864", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "E1BHC4", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHC4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 318, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHC4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHC4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHC4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHF3-1", "uniprot_ac": "E1BHF3", "uniprot_id": "E1BHF3_BOVIN", "mass": { "chemical_mass": 47738.0, "monoisotopic_mass": 47738.0 }, "refseq": {}, "gene_names": [ { "name": "GLI4", "type": "recommended", "evidence": [ { "id": "E1BHF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ] } ], "protein_names": [ { "name": "GLI family zinc finger 4", "type": "synonym", "evidence": [ { "id": "E1BHF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHF3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLI4", "url": "https://www.uniprot.org/uniprotkb/E1BHF3", "locus": { "chromosome": "14", "start_pos": 1323101, "end_pos": 1335654, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003606", "url": "https://www.ensembl.org/id/ENSBTAG00000003606" } ] } } ], "crossref": [ { "id": "E1BHF3", "url": "https://alphafold.ebi.ac.uk/entry/E1BHF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003606", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003606", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518201", "url": "https://www.ncbi.nlm.nih.gov/gene/518201", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AQHHEAQ", "url": "https://omabrowser.org/oma/group/AQHHEAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NH34", "url": "https://www.orthodb.org/?gene=A0A3Q1NH34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BHF3", "url": "https://www.orthodb.org/?gene=E1BHF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF425", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF425", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NH34", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NH34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHF3-1", "url": "https://www.uniprot.org/uniprotkb/E1BHF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCQKWTDGWRSCWQIPSSRLCPRSAPAAHRQQVPGVHSFSRPWGKMAALGDGQEPPHVLSPVSFESPGTPGAHHHEAQLHLHLHGHQHGFPSSSPEVPSQPPQEPSDLDFQEVAEVQICRDTCWSGSESEPEQAPSSPSPHGPEDEVHQAGGVLRTLLRSLPRRPGGGDRFGQEPSLERSAGQTPRAGPRSQKRDTWLGSQGASGTEGSPGRTAELAGGLSRGSGLGTQQGGPRGGKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECDKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRVHNGEKPYECGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 433, "header": "tr|E1BHF3-1|E1BHF3_BOVIN Isoform 1 of GLI family zinc finger 4 OS=Bos taurus OX=9913 GN=GLI4 PE=3 SV=3 CANONICAL=E1BHF3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NH34-1", "url": "https://www.uniprot.org/uniprotkb/E1BHF3/entry#A0A3Q1NH34-1", "sequence": { "sequence": "CLEIWASWFGWGPLCGWSHQPCCSPQQDLGVSSSPEVPSQPPQEPSDLDFQEVAEVQICRDTCWSGSESEPEQAPSSPSPHGPEDEVHQAGGVLRTLLRSLPRRPGGGDRFGQEPSLERSAGQTPRAGPRSQKRDTWLGSQGASGTEGSPGRTAELAGGLSRGSGLGTQQGGPRGGKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECDKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRVHNGEKPYECGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 372, "header": "tr|A0A3Q1NH34-1|A0A3Q1NH34_BOVIN Computationally mapped isoform of GLI family zinc finger 4 OS=Bos taurus OX=9913 GN=GLI4 PE=3 SV=2 CANONICAL=E1BHF3-1" }, "locus": { "chromosome": "14", "start_pos": 1328340, "end_pos": 1324105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071209.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071209.2" } ] } }, { "isoform_ac": "A0AAA9TKE2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHF3/entry#A0AAA9TKE2-1", "sequence": { "sequence": "MAALGDGQEPPHVLSPVSFESPGTPGAHHHEAQLHLHLHGHQHGSESEPEQAPSSPSPHGPEDEVHQAGGVLRTLLRSLPRRPGGGDRFGQEPSLERSAGQTPRAGPRSQKRDTWLGSQGASGTEGSPGRTAELAGGLSRGSGLGTQQGGPRGGKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECDKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRVHNGEKPYECGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 350, "header": "tr|A0AAA9TKE2-1|A0AAA9TKE2_BOVIN Computationally mapped isoform of GLI family zinc finger 4 OS=Bos taurus OX=9913 GN=GLI4 PE=3 SV=1 CANONICAL=E1BHF3-1" }, "locus": { "chromosome": "14", "start_pos": 1328743, "end_pos": 1324105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120652.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120652.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096733.1" } ] } }, { "isoform_ac": "A0AAA9TVR5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHF3/entry#A0AAA9TVR5-1", "sequence": { "sequence": "SPTSPPPPWSSTCSSPEVPSQPPQEPSDLDFQEVAEVQICRDTCWSGSESEPEQAPSSPSPHGPEDEVHQAGGVLRTLLRSLPRRPGGGDRFGQEPSLERSAGQTPRAGPRSQKRDTWLGSQGASGTEGSPGRTAELAGGLSRGSGLGTQQGGPRGGKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECDKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRVHNGEKPYECGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 353, "header": "tr|A0AAA9TVR5-1|A0AAA9TVR5_BOVIN Computationally mapped isoform of GLI family zinc finger 4 OS=Bos taurus OX=9913 GN=GLI4 PE=3 SV=1 CANONICAL=E1BHF3-1" }, "locus": { "chromosome": "14", "start_pos": 1328651, "end_pos": 1324105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101644.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101644.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101505.1" } ] } }, { "isoform_ac": "E1BHF3-1", "url": "https://www.uniprot.org/uniprotkb/E1BHF3/entry#E1BHF3-1", "sequence": { "sequence": "MGCQKWTDGWRSCWQIPSSRLCPRSAPAAHRQQVPGVHSFSRPWGKMAALGDGQEPPHVLSPVSFESPGTPGAHHHEAQLHLHLHGHQHGFPSSSPEVPSQPPQEPSDLDFQEVAEVQICRDTCWSGSESEPEQAPSSPSPHGPEDEVHQAGGVLRTLLRSLPRRPGGGDRFGQEPSLERSAGQTPRAGPRSQKRDTWLGSQGASGTEGSPGRTAELAGGLSRGSGLGTQQGGPRGGKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECDKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRVHNGEKPYECGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 433, "header": "tr|E1BHF3-1|E1BHF3_BOVIN Isoform 1 of GLI family zinc finger 4 OS=Bos taurus OX=9913 GN=GLI4 PE=3 SV=3 CANONICAL=E1BHF3-1" }, "locus": { "chromosome": "14", "start_pos": 1335455, "end_pos": 1324105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004687.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004687.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004687.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004687.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 70, "start_aa": "Thr", "end_pos": 70, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr70", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QPF7-1", "protein_name": "GLI family zinc finger 4", "gene_name": "GLI4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "TQLLGDWCPGCARQSRCCQSEFWKLWSGALCANKGKQHRRLDTWGLSPGVGRHPSGWCPLAVLCPACSSPPRPGLRTRFLCHFINKESFQPPEKAPIVLPASLSSPWSTTPQRCGVHSSPGPGGLGPGFPVCSPEVPSQLPQEEGLWDLDLQDEQEDQIARDTCLPDSESEPQLAPSSPRPRGPGEEVHGGRDRGALRTLLRRLARRPKCGDGLGQECSLEQPPGAGPCTQKRGGPWLGPQGALGTEGGPERAAELAGSCARGSGLGARQGGPRGGKPHRCEACGKSFRYNSLLLKHQRIHTGEKPYECPDCGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHVRVHNGEKPYACGECGQAFSQSSNLLRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECPDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHSRE", "length": 472 }, "evidence": [ { "id": "E1BHF3", "url": "https://omabrowser.org/oma/group/E1BHF3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P10075-1", "protein_name": "Zinc finger protein GLI4", "gene_name": "GLI4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE", "length": 376 }, "evidence": [ { "id": "E1BHF3", "url": "https://omabrowser.org/oma/group/E1BHF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BHF3", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHF3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 433, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHF3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHF3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHF3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 240, "end_pos": 267, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 70 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHG5-1", "uniprot_ac": "E1BHG5", "uniprot_id": "E1BHG5_BOVIN", "mass": { "chemical_mass": 95611.0, "monoisotopic_mass": 95611.0 }, "refseq": {}, "gene_names": [ { "name": "COL21A1", "type": "recommended", "evidence": [ { "id": "E1BHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XXI) chain", "type": "recommended", "evidence": [ { "id": "E1BHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHG5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Collagen VI acts as a cell-binding protein.", "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5#function" }, { "database": "UniProtKB", "id": "ARBA00043858", "url": "https://www.uniprot.org/uniprotkb/ARBA00043858#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL21A1", "url": "https://www.uniprot.org/uniprotkb/E1BHG5", "locus": { "chromosome": "23", "start_pos": 4261679, "end_pos": 4026788, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033515", "url": "https://www.ensembl.org/id/ENSBTAG00000033515" } ] } } ], "crossref": [ { "id": "E1BHG5", "url": "https://alphafold.ebi.ac.uk/entry/E1BHG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033515", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033515", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000046193", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0ABZ3NNI8", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABZ3NNI8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHG5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHHITFLWIISILLLQNSVLAEDGEIRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSHESGENLMAAMESIHYLGGNTRTGKAIQFALDYLFAKSARFLTKIAVVLTDGKSQDEVKDAAEAARDSRITLFAIGVGSETEEAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDEKGFDILLGLGIKKKAKKRVQLLPTKIKGYEITSKVDLSEFTSNVFPEGLPPSYVFVSTQRFKVKKMWDLWRILTIDGRPQIAVTLNGVDKTLLFTTTSIINGSQVVTFADPRVKILFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGIFISGQTQIGKYSGKEETVQFEVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTAAPCICPPGKPGLQGPKGDPGQPGNPGYPGRPGQDGKPGYQGIAGSPGVPGSPGIQGAQGLPGYKGEPGRDGEKGAKGEQGNAGFPGLPGRAGEPGRHGKDGLMGSPGFKGEAGPPGAPGQDGSRGEPGIPGFPGNQGLMGQKGDTGPPGPLGKKGAPGIPGLMGSDGSPGQPGAPGSKGTKGEPGLQGLPGASGLKGEPGAVGPPGEPGYLGLPGIQGKKGDKGNQGERGIQGQKGENGRPGIPGFQGIQGHHGAKGEMGEKGEPGARGATGAKGESGVDGQMGPPGPQGPPGQPGDPGPPGMDGKPGREFSEQFIRQVCTDVLRAQLPVLLQSGRIQSCDHCQPQHGSPGIPGPPGPMGPEGPRGFPGLPGRDGVPGLMGAPGRPGVKGLKGLPGRNGAKGSQGLGYPGAQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGAPGICDPSLCFSVIVGRDPFRKGPNY", "length": 921, "header": "tr|E1BHG5-1|E1BHG5_BOVIN Isoform 1 of Collagen alpha-1(XXI) chain OS=Bos taurus OX=9913 GN=COL21A1 PE=3 SV=4 CANONICAL=E1BHG5-1" }, "isoforms": [ { "isoform_ac": "A0ABZ3NNI8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHG5/entry#A0ABZ3NNI8-1", "sequence": { "sequence": "MAHHITFLWIISILLLQNSVLAEDGEIRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSHESGENLMAAMESIHYLGGNTRTGKAIQFALDYLFAKSARFLTKIAVVLTDGKSQDEVKDAAEAARDSRITLFAIGVGSETEEAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDEKGFDILLGLGIKKKAKKRVQLLPTKIKGYEITSKVDLSEFTSNVFPEGLPPSYVFVSTQRFKVKKMWDLWRILTIDGRPQIAVTLNGVDKTLLFTTTSIINGSQVVTFADPRVKILFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGIFISGQTQIGKYSGKEETVQFEVQKLRIYCDPEQNNRETACEIPGFVSRCLNGPSDVGSTAAPCICPPGKPGLQGPKGDPGQPGNPGYPGRPGQDGISGNSRITRCSRIPGNTRSTRTARLQRRTWERWRKGSSAVCT", "length": 518, "header": "tr|A0ABZ3NNI8-1|A0ABZ3NNI8_BOVIN Computationally mapped isoform of Collagen alpha-1(XXI) chain OS=Bos taurus OX=9913 GN=COL21A1 PE=3 SV=1 CANONICAL=E1BHG5-1" }, "locus": { "chromosome": "23", "start_pos": 4168297, "end_pos": 4094775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074238.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074238.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071931.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071931.3" } ] } }, { "isoform_ac": "E1BHG5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHG5/entry#E1BHG5-1", "sequence": { "sequence": "MAHHITFLWIISILLLQNSVLAEDGEIRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSHESGENLMAAMESIHYLGGNTRTGKAIQFALDYLFAKSARFLTKIAVVLTDGKSQDEVKDAAEAARDSRITLFAIGVGSETEEAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDEKGFDILLGLGIKKKAKKRVQLLPTKIKGYEITSKVDLSEFTSNVFPEGLPPSYVFVSTQRFKVKKMWDLWRILTIDGRPQIAVTLNGVDKTLLFTTTSIINGSQVVTFADPRVKILFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGIFISGQTQIGKYSGKEETVQFEVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTAAPCICPPGKPGLQGPKGDPGQPGNPGYPGRPGQDGKPGYQGIAGSPGVPGSPGIQGAQGLPGYKGEPGRDGEKGAKGEQGNAGFPGLPGRAGEPGRHGKDGLMGSPGFKGEAGPPGAPGQDGSRGEPGIPGFPGNQGLMGQKGDTGPPGPLGKKGAPGIPGLMGSDGSPGQPGAPGSKGTKGEPGLQGLPGASGLKGEPGAVGPPGEPGYLGLPGIQGKKGDKGNQGERGIQGQKGENGRPGIPGFQGIQGHHGAKGEMGEKGEPGARGATGAKGESGVDGQMGPPGPQGPPGQPGDPGPPGMDGKPGREFSEQFIRQVCTDVLRAQLPVLLQSGRIQSCDHCQPQHGSPGIPGPPGPMGPEGPRGFPGLPGRDGVPGLMGAPGRPGVKGLKGLPGRNGAKGSQGLGYPGAQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGAPGICDPSLCFSVIVGRDPFRKGPNY", "length": 921, "header": "tr|E1BHG5-1|E1BHG5_BOVIN Isoform 1 of Collagen alpha-1(XXI) chain OS=Bos taurus OX=9913 GN=COL21A1 PE=3 SV=4 CANONICAL=E1BHG5-1" }, "locus": { "chromosome": "23", "start_pos": 4260675, "end_pos": 4094775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036339.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036339.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036200.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036200.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ], "pmid": "" }, { "name": "collagen type VI trimer", "id": "GO:0005589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005589", "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BHG5", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHG5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 921, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHG5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHG5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHG5" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 211, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 329, "end_pos": 331 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHH2-1", "uniprot_ac": "E1BHH2", "uniprot_id": "E1BHH2_BOVIN", "mass": { "chemical_mass": 61149.0, "monoisotopic_mass": 61149.0 }, "refseq": { "ac": "XP_002697494", "name": "zinc finger protein with KRAB and SCAN domains 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697494" }, "gene_names": [ { "name": "ZKSCAN4", "type": "recommended", "evidence": [ { "id": "E1BHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ] }, { "name": "ZKSCAN4", "type": "synonym", "evidence": [ { "id": "XP_002697494", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697494" } ] } ], "protein_names": [ { "name": "Zinc finger protein 307", "type": "recommended", "evidence": [ { "id": "E1BHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein with KRAB and SCAN domains 4", "type": "synonym", "evidence": [ { "id": "XP_002697494", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697494" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZKSCAN4", "url": "https://www.uniprot.org/uniprotkb/E1BHH2", "locus": { "chromosome": "23", "start_pos": 30441497, "end_pos": 30450112, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003575", "url": "https://www.ensembl.org/id/ENSBTAG00000003575" } ] } } ], "crossref": [ { "id": "E1BHH2", "url": "https://alphafold.ebi.ac.uk/entry/E1BHH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003575", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003575", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539620", "url": "https://www.ncbi.nlm.nih.gov/gene/539620", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539620", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539620", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KESQWEN", "url": "https://omabrowser.org/oma/group/KESQWEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHH2", "url": "https://www.orthodb.org/?gene=E1BHH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697494", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697494", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARESKESAALDAQSAEDRTGILTVKVEKEDASVLAAEARAPGSPAPSPEHSRQRFRGFRYPEAEGPREALSRLRELCRLWLRPETHSKEQMLELLVLEQFLTILPTDLQSWMREQHPESGEEVVALLEYLERQPDGPMPQVLGGGQEQELLCCKMAVLTPIQRPQNIQFQPVKALLKRESLGSIPDRVLQVPRLAPGGRCREDAVIATRFAPGSQGPFKMEDVALTVSPGWTQLDSSQVNLYGDKRQENHGSLTSLGGVVQPKIRELPPDEDHPTQEPGQIPCHLGKATGQIPACAEAGEQEGRLQRKKTAAGNRRHYCHECGKTFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGNKNLQNPDPGRTWESQGRKESQWENVEVPVSYKCNECERSFTRNRSLIEHQKIHTGEKPFQCDTCGKGFTRTSYLIQHQRSHVGKKILSP", "length": 543, "header": "tr|E1BHH2-1|E1BHH2_BOVIN Isoform 1 of Zinc finger protein 307 OS=Bos taurus OX=9913 GN=ZKSCAN4 PE=3 SV=1 CANONICAL=E1BHH2-1" }, "isoforms": [ { "isoform_ac": "E1BHH2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHH2/entry#E1BHH2-1", "sequence": { "sequence": "MARESKESAALDAQSAEDRTGILTVKVEKEDASVLAAEARAPGSPAPSPEHSRQRFRGFRYPEAEGPREALSRLRELCRLWLRPETHSKEQMLELLVLEQFLTILPTDLQSWMREQHPESGEEVVALLEYLERQPDGPMPQVLGGGQEQELLCCKMAVLTPIQRPQNIQFQPVKALLKRESLGSIPDRVLQVPRLAPGGRCREDAVIATRFAPGSQGPFKMEDVALTVSPGWTQLDSSQVNLYGDKRQENHGSLTSLGGVVQPKIRELPPDEDHPTQEPGQIPCHLGKATGQIPACAEAGEQEGRLQRKKTAAGNRRHYCHECGKTFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGNKNLQNPDPGRTWESQGRKESQWENVEVPVSYKCNECERSFTRNRSLIEHQKIHTGEKPFQCDTCGKGFTRTSYLIQHQRSHVGKKILSP", "length": 543, "header": "tr|E1BHH2-1|E1BHH2_BOVIN Isoform 1 of Zinc finger protein 307 OS=Bos taurus OX=9913 GN=ZKSCAN4 PE=3 SV=1 CANONICAL=E1BHH2-1" }, "locus": { "chromosome": "23", "start_pos": 30449913, "end_pos": 30442501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004651.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004651.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004651.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004651.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539620", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539620", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZCK0-1", "protein_name": "Zinc finger protein 307", "gene_name": "Zkscan4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAREPGACAALNAPSAEEGTGFLVVKVEPEEASQLAEEPSWLGSPGPDRSRQRFRAFRYPDAAGPRQALSRLRELCRQWLRPDMHSKEQILELLVLEQFLTILPGELQAWVREQHPDSGEEVVALLEYLDRQLDETPPQVPTGEWSRELLCCKVALVTSSQDSQSSHSQAMKSLFKHESQESLECSPLQARGLEMKPETRGLPLAEEYKEQKPEQTVWFLGEDTVQISTSTEASEQEGKLQTTQKNATGNRRFYCHECGKSFAQSSGLTKHKRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFTQSCSLLEHHKIHTGEKPFQCNLCGKAFRRSSHLLRHQRIHGDKAAPKLLHGETWEGQSRVASLGDIVEAPETYQCNECERSFTRSRSLIEHKKIHTGEKPYQCDACGKGFTRTSYLVQHRRSHVGKKLSHSDL", "length": 480 }, "evidence": [ { "id": "E1BHH2", "url": "https://omabrowser.org/oma/group/E1BHH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S1S1-1", "protein_name": "Zinc finger protein 307", "gene_name": "ZKSCAN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARESKESAALDAPSAEDRTGILTVKVEKEEASSLAAEAGAPGSPAPGLEHLRQRFRGFRYPEAEGPREALSRLRELCRLWLRPEMHSKEQILELLVLEQFLTILPGDLQSWVREQHPESGEEVVVLLEYLERQLDEPVPQVPGDDQGQELLRCKMAVLTPAQKSRNAQFQPMKALLKHESLGPQSSPNRALQVPRLPLGGRCREDAVVAANLTQESQRPLKMEDVALTLSPGWTQLDSSQVNSYRDERQENCGSLMALGGEIRTKLRDLPPEEEPPEQEPGQVPCHLGEAIGQIPVCAEAGEQEGRLQRKQKGAAGTRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKHVQNPDRGETWESRDRMEHQWQNVEAPVSFKCNACERSFTRNRSLIEHQKIHTGEKPYPCDACGKGFTRPSYLVQHQRSHVGKKILSP", "length": 546 }, "evidence": [ { "id": "E1BHH2", "url": "https://omabrowser.org/oma/group/E1BHH2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5SZT6-1", "protein_name": "Zinc finger with KRAB and SCAN domains 4", "gene_name": "Zkscan4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAREPGTSAALNARSAEEGTGLLVVKVEQEEASPLAEETSWLGSPGPDRSRQRFRAFRYPEAAGPRQALSRLRELCRQWLRPDMHSKEQILELLVLEQFLTILPGELQTWVREQHPDSGEEVVALLEYLDRQLDDTPPQVSTGEWSRELLCCKVAVVTPSQDSQSSHCQAMKSLFKHESQESLECSPLQARGLEMKPETRDLPRAEEYRDQKPEQTVCFLGEDTVPIPTGAEASEQEGKLQTAQKSATGTRRHFCCECGKSFAQSSGLTKHKRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFTQSCSLLEHHKIHTGEKPFQCNLCGKAFRRSSHLLRHQRIHGDKTAPKPLHGEAWEGQSPVAGQGEDVEAPETYQCSECERSFTRRRSLLEHKKIHTGEKPYQCDACGKGFTRTSYLAQHQRSHVGKKLSHSDL", "length": 480 }, "evidence": [ { "id": "E1BHH2", "url": "https://omabrowser.org/oma/group/E1BHH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969J2-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 4", "gene_name": "ZKSCAN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAREPRKNAALDAQSAEDQTGLLTVKVEKEEASALTAEVRAPCSPARGPERSRQRFRGFRYPEAAGPREALSRLRELCGQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVPVGDQGQELLCCKMALLTQTQGSQSSQCQPMKALFKHESLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPGSQGLLKMEDVALTLTPGWTQLDSSQVNLYRDEKQENHSSLVSLGGEIQTKSRDLPPVKKLPEKEHGKICHLREDIAQIPTHAEAGEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKNVQNPEHGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTSYLVQHQRSHVGKKTLSQ", "length": 545 }, "evidence": [ { "id": "E1BHH2", "url": "https://omabrowser.org/oma/group/E1BHH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BHH2", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHH2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 543, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHH2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHH2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 318, "end_pos": 345, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH2" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 134, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 497, "end_pos": 499 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHH6-1", "uniprot_ac": "E1BHH6", "uniprot_id": "E1BHH6_BOVIN", "mass": { "chemical_mass": 72188.0, "monoisotopic_mass": 72188.0 }, "refseq": {}, "gene_names": [ { "name": "PODN", "type": "recommended", "evidence": [ { "id": "E1BHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ] } ], "protein_names": [ { "name": "Podocan", "type": "recommended", "evidence": [ { "id": "E1BHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PODN", "url": "https://www.uniprot.org/uniprotkb/E1BHH6", "locus": { "chromosome": "3", "start_pos": 93160141, "end_pos": 93175539, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012514", "url": "https://www.ensembl.org/id/ENSBTAG00000012514" } ] } } ], "crossref": [ { "id": "E1BHH6", "url": "https://alphafold.ebi.ac.uk/entry/E1BHH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012514", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012514", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CAADSDF", "url": "https://omabrowser.org/oma/group/CAADSDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13306", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13306", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHH6-1", "url": "https://www.uniprot.org/uniprotkb/E1BHH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSMGPSPLAALPDKLSQPRSLGESELTPPAGTMAQGWALLLLLLLPRQLGVVLAVRAPGFGRSGARSLSPEENEFSEEEPVLVLSPEEPGRGPATIGCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPRELSRLHRLETLNLQNNRLTSRGLPEEAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNHLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLRAQGIHPRAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGVGRDDFATTYHLEELNLSYNRITSPRVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKIKRNELVALARGALAGMAQLRELYLTGNRLRNRALGPRAWTDLSGLQLLDIAGNQLTEIPGGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVESAFRKLKHLQVLDIEGNFEFGDVSKDRGRLEKEEEEEDDDEEEEEERR", "length": 644, "header": "tr|E1BHH6-1|E1BHH6_BOVIN Isoform 1 of Podocan OS=Bos taurus OX=9913 GN=PODN PE=3 SV=3 CANONICAL=E1BHH6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEE7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHH6/entry#A0AAA9SEE7-1", "sequence": { "sequence": "MAQGWALLLLLLLPRQLGVVLAVRAPGFGRSGARSLSPEENEFSEEEPVLVLSPEEPGRGPATIGCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNKLEKIPPGAFSELSNLRELYLQNNHLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLRAQGIHPRAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGVGRDDFATTYHLEELNLSYNRITSPRVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKIKRNELVALARGALAGMAQLRELYLTGNRLRNRALGPRAWTDLSGLQLLDIAGNQLTEIPGGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVESAFRKLKHLQVLDIEGNFEFGDVSKDRGRLEKEEEEEDDDEEEEEERR", "length": 469, "header": "tr|A0AAA9SEE7-1|A0AAA9SEE7_BOVIN Computationally mapped isoform of Podocan OS=Bos taurus OX=9913 GN=PODN PE=4 SV=1 CANONICAL=E1BHH6-1" }, "locus": { "chromosome": "3", "start_pos": 93175365, "end_pos": 93163134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132496.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132496.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082221.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082221.1" } ] } }, { "isoform_ac": "E1BHH6-1", "url": "https://www.uniprot.org/uniprotkb/E1BHH6/entry#E1BHH6-1", "sequence": { "sequence": "MTSMGPSPLAALPDKLSQPRSLGESELTPPAGTMAQGWALLLLLLLPRQLGVVLAVRAPGFGRSGARSLSPEENEFSEEEPVLVLSPEEPGRGPATIGCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPRELSRLHRLETLNLQNNRLTSRGLPEEAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNHLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLRAQGIHPRAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGVGRDDFATTYHLEELNLSYNRITSPRVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKIKRNELVALARGALAGMAQLRELYLTGNRLRNRALGPRAWTDLSGLQLLDIAGNQLTEIPGGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVESAFRKLKHLQVLDIEGNFEFGDVSKDRGRLEKEEEEEDDDEEEEEERR", "length": 644, "header": "tr|E1BHH6-1|E1BHH6_BOVIN Isoform 1 of Podocan OS=Bos taurus OX=9913 GN=PODN PE=3 SV=3 CANONICAL=E1BHH6-1" }, "locus": { "chromosome": "3", "start_pos": 93175464, "end_pos": 93163134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016614.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016614.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016614.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016614.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3GTN5-1", "protein_name": "Podocan", "gene_name": "Podn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSRGLPLLLLLPQLLLGPVLAVRAPVFGQSDTHSLSPEENEFVEEEQPVLVLSPEEPEPGPTTINCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELARLQRLETLNLQNNRLTSRGLPEEAFEHLTSLNYLYLANNKLTLAPRSLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNFLTDEGLDNETFWKLSSLEYLDLSSNNLSRIPAGLPRSLVLLHLEKNVIQNVDADVLTPIRSLEYLLLHSNQLRAEGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQMHRDAFRKLRLLRSLDLSGNRLQTLPPGLPRNVHVLKVKRNELAALARGALAGMAQLRELYLTGNRLRSRALGPRAWVDLAGLQLLDIAGNQLTEIPQGLPPSLEYLYLQNNKISSVPANAFDSTPNLKGVFLRFNKLAMGSVVESAFRRLKHLQVLDIEGNFEVGDISKDRGHIDEEEEEEEDEEDEEEETGP", "length": 614 }, "evidence": [ { "id": "E1BHH6", "url": "https://omabrowser.org/oma/group/E1BHH6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P11915-1", "protein_name": "Sterol carrier protein 2", "gene_name": "Scp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSVALNSPRLPRVFVVGVGMTKFMKPGGENSRDYPDLAKEAGQKALADRQIPYSAVEQACVGYVYGESTCGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMAQQLVQGGLANCVLALGFEKMEKGSLGTKYSDRSNPLEKHIDVLINKYGMSACPFAPQLFGSAGKEHMETYGTKVEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEIMKSRPVFDFLTVLQCCPTSDGAAAAIVSSEEFVQKHGLQSKAVEIVAQEMVTDMPSTFEEKSVIKMVGYDMSKEAARKCYEKSGLGPSDVDVIELHDCFSTNELLTYEALGLCPEGQGGALVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAAVVTLYRMGFPEAASSFRTHQISAAPTSSAGDGFKANLIFKEIEKKLEEEGEEFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPDSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGLAMKLQSLQLQPDKAKL", "length": 547 }, "evidence": [ { "id": "E1BHH6", "url": "https://omabrowser.org/oma/group/E1BHH6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TQ62-1", "protein_name": "Podocan", "gene_name": "Podn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGSRGLPLLLLVLQLFLGPVLPVRAPVFGRSDTPTLSPEENEFVEEENQPVLVLSSEEPEPGPATVDCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLQRLETLNLQNNRLTSRGLPEEAFEHLTSLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDHMFNGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIQSVEADVLTPIRNLEYLLLHSNQLQAKGIHPLAFQGLKKLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQMHRDAFRKLRLLRSLDLSGNRLQTLPPGLPKNVHVLKVKRNELAALARGALAGMAQLRELYLTGNRLRSRALGPRAWVDLAGLQLLDIAGNQLTEVPEGLPPSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVESAFRRLKHLQVLDIEGNFEFGNGSKDKDEEEEEEEEEEDEEEETR", "length": 611 }, "evidence": [ { "id": "E1BHH6", "url": "https://omabrowser.org/oma/group/E1BHH6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z5L7-1", "protein_name": "Podocan", "gene_name": "PODN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSRVLLLLLLLPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEETR", "length": 613 }, "evidence": [ { "id": "E1BHH6", "url": "https://omabrowser.org/oma/group/E1BHH6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "E1BHH6", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 644, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHH6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHH6" }, { "id": "SM00013", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRNT", "eco_id": "ECO_0000259", "start_pos": 98, "end_pos": 131, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 441, "end_pos": 443 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHJ1-1", "uniprot_ac": "E1BHJ1", "uniprot_id": "E1BHJ1_BOVIN", "mass": { "chemical_mass": 43774.0, "monoisotopic_mass": 43774.0 }, "refseq": { "ac": "NP_001179575", "name": "solute carrier family 35 member E2B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575" }, "gene_names": [ { "name": "SLC35E2B", "type": "recommended", "evidence": [ { "id": "E1BHJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ] }, { "name": "SLC35E2B", "type": "synonym", "evidence": [ { "id": "NP_001179575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575" } ] }, { "name": "SLC35E2", "type": "synonym", "evidence": [ { "id": "NP_001179575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575" } ] } ], "protein_names": [ { "name": "Solute carrier family 35 member E2", "type": "synonym", "evidence": [ { "id": "E1BHJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 35 member E2B", "type": "synonym", "evidence": [ { "id": "NP_001179575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575" } ] }, { "name": "solute carrier family 35, member E2", "type": "synonym", "evidence": [ { "id": "NP_001179575", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575" } ] } ], "function": [ { "annotation": "Putative transporter.", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1#function" }, { "database": "UniProtKB", "id": "ARBA00093767", "url": "https://www.uniprot.org/uniprotkb/ARBA00093767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC35E2B", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1", "locus": {} } ], "crossref": [ { "id": "E1BHJ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BHJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031749", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527591", "url": "https://www.ncbi.nlm.nih.gov/gene/527591", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527591", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527591", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFPCGMY", "url": "https://omabrowser.org/oma/group/YFPCGMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHJ1", "url": "https://www.orthodb.org/?gene=E1BHJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03151", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03151", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179575", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHJ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASAKPPALGELDPGPGEKPGGRPLLAWAPVFSHRSEKIALGQSDGSPEEQVLTVTVTETTVIEADLGVWGARALTYLTLWFFFSFCTLFLNKYILSLLEGEPSMLGAVQMLSTTLIGCVKIFVPCCLYQHKTRLSYPPNFIMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVILSRTVLGEHTGLLVNLSLIPVMGGLALCTATEMSFNFLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAAELQFYTSTAAVAMLVPAWIFFMDLPVIGRSGRSFRYSQDVVLLLLADGVLFHLQSVTAYALMGRISPVTFSVASTVKHALSIWLSVIVFGNKVTSLSAVGTVLVTAGVLLYNKAKQQQREAMQSLASATTQPPDGSSELLLPQDPRPHH", "length": 405, "header": "tr|E1BHJ1-1|E1BHJ1_BOVIN Isoform 1 of Solute carrier family 35 member E2 OS=Bos taurus OX=9913 GN=SLC35E2B PE=3 SV=1 CANONICAL=E1BHJ1-1" }, "isoforms": [ { "isoform_ac": "E1BHJ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1/entry#E1BHJ1-1", "sequence": { "sequence": "MSASAKPPALGELDPGPGEKPGGRPLLAWAPVFSHRSEKIALGQSDGSPEEQVLTVTVTETTVIEADLGVWGARALTYLTLWFFFSFCTLFLNKYILSLLEGEPSMLGAVQMLSTTLIGCVKIFVPCCLYQHKTRLSYPPNFIMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVILSRTVLGEHTGLLVNLSLIPVMGGLALCTATEMSFNFLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAAELQFYTSTAAVAMLVPAWIFFMDLPVIGRSGRSFRYSQDVVLLLLADGVLFHLQSVTAYALMGRISPVTFSVASTVKHALSIWLSVIVFGNKVTSLSAVGTVLVTAGVLLYNKAKQQQREAMQSLASATTQPPDGSSELLLPQDPRPHH", "length": 405, "header": "tr|E1BHJ1-1|E1BHJ1_BOVIN Isoform 1 of Solute carrier family 35 member E2 OS=Bos taurus OX=9913 GN=SLC35E2B PE=3 SV=1 CANONICAL=E1BHJ1-1" }, "locus": { "chromosome": "16", "start_pos": 50979043, "end_pos": 50971220, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045013.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045013.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042442.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042442.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527591", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527591", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RJC4-1", "protein_name": "Solute carrier family 35 member E2", "gene_name": "SLC35E2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSASAKPAAPAEPAPGPREKPGGQPLLAWGPVFGSRGEKVALGQSDGAAERVLTVTVTETTVLESDLGAWGARALLYLSLWFFFSFCTLFLNKHILSLLEGEPSTLGAVQMLSTTLIGCVKIVVPCCLYQHKTRLSYPPNFIVTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVILSRMVLGEHTGLLVNLSLLPVMGGLALCTATEMSFNFLGFSAALSTNVMDCLQNVFSKKLLSGDKYRFSAAELQFYTSAAAVAMLVPAWAFFMDLPVIGRSGRSFRYSQDVVLLLLADGLLFHLQSVTAYALMGRISPVTFSVASTVKHALSIWLSVIVFGNRVTSLSAVGTVLVTAGVLLYNKAKQQQHEAMQSLAMAAGRMPDNSSEPLLPVDPRPHH", "length": 404 }, "evidence": [ { "id": "E1BHJ1", "url": "https://omabrowser.org/oma/group/E1BHJ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IK04-1", "protein_name": "Solute carrier family 35 member E2A isoform X1", "gene_name": "LOC100773575", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSAKSQGPEETVPDCEEELKGKTLLTWGPLFGHRSEKIVFTKGDGSPEESLLTVTITETTVIESDLGVWSSRALIYLTLWFFFSFCTLFLNKYILSLLEGEPSMLGAVQMLSTTLIGCVKIFVPCCLYQHKTRLSYPPNFIMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNILGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVALLIPAWTFFMDVPVIGRSGKSFSYSQDIVLLLLTDGALFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSIIVFGNKITSLSAIGTILVTMGVLLYNKARQYQQETMQSLATATSRGPEDDTESLVPLDSRQHH", "length": 404 }, "evidence": [ { "id": "E1BHJ1", "url": "https://omabrowser.org/oma/group/E1BHJ1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0CK96-1", "protein_name": "Solute carrier family 35 member E2B", "gene_name": "SLC35E2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAKSDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNVLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVFFTDVPVIGRSGKSFSYNQDVVLLLLTDGVLFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQEALQSLAAATGRAPDDTVEPLLPQDPRQHP", "length": 405 }, "evidence": [ { "id": "E1BHJ1", "url": "https://omabrowser.org/oma/group/E1BHJ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C811-1", "protein_name": "Solute carrier family 35 member E2A", "gene_name": "Slc35e2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAAAKSQVPEEAAPGCEEEPKGKTLLTWGSLFGHRSEKIVFTKGDGSPEESLLTVTITETTVIESDLGVWSSRALIYLTLWFFFSFCTLFLNKYILSLLEGEPSMLGAVQMLSTTLIGCVKIFVPCCLYQHKTRLSYPPNFIMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNILGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVALLIPAWTFFMDIPVIGRSGKSFSYSQDIVLLLLTDGALFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSIIVFGNKITSLSAIGTILVTLGVLLYNKARQYQQETMQSLVTATSRNPEDDTEPLVPQDSRQHH", "length": 405 }, "evidence": [ { "id": "E1BHJ1", "url": "https://omabrowser.org/oma/group/E1BHJ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LDH3-1", "protein_name": "Probable sugar phosphate/phosphate translocator At1g12500", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVEAQSWTTRRMSNPRFDAAATAAPTIVDIPGTPPHSSASSPLKPFFLSSPTVSPTILTAAIIAAWFGSNIGVLLLNKYLLFYYGFRYPIFLTMTHMLSCAAYSSAVINIAGIVPRQHILSRRQFLKILSLSAIFCLSVVCGNTSLRYIPVSFNQAIGATTPFFTAVFSFLITCKTESTEVYLALLPVVSGIVLASNSEPSFHLFGFLICVASTAGRALKSVVQGIILTSESEKLHSMNLLLYMAPMAACILLPFTLYIEGNVLRVLIEKARTDPLIIFLLAGNATVAYLVNLTNFLVTKHTSALTLQVLGNGKAAVAAGVSVLIFRNPVTVMGIAGFGVTIMGVVLYSEARKRSKLLNQK", "length": 361 }, "evidence": [ { "id": "E1BHJ1", "url": "https://omabrowser.org/oma/group/E1BHJ1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHJ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 405, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHJ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHJ1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHJ9-1", "uniprot_ac": "E1BHJ9", "uniprot_id": "E1BHJ9_BOVIN", "mass": { "chemical_mass": 20411.0, "monoisotopic_mass": 20411.0 }, "refseq": { "ac": "XP_002691485", "name": "gastrokine-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691485" }, "gene_names": [ { "name": "GKN2", "type": "recommended", "evidence": [ { "id": "E1BHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" } ] }, { "name": "GKN2", "type": "synonym", "evidence": [ { "id": "XP_002691485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691485" } ] } ], "protein_names": [ { "name": "Gastrokine-2", "type": "recommended", "evidence": [ { "id": "E1BHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9/entry#names_and_taxonomy" } ] }, { "name": "Blottin", "type": "synonym", "evidence": [ { "id": "E1BHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9/entry#names_and_taxonomy" } ] }, { "name": "gastrokine-2", "type": "synonym", "evidence": [ { "id": "XP_002691485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691485" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHJ9", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GKN2", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9", "locus": { "chromosome": "11", "start_pos": 67286584, "end_pos": 67294237, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017199", "url": "https://www.ensembl.org/id/ENSBTAG00000017199" } ] } } ], "crossref": [ { "id": "E1BHJ9", "url": "https://alphafold.ebi.ac.uk/entry/E1BHJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017199", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017199", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512001", "url": "https://www.ncbi.nlm.nih.gov/gene/512001", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512001", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512001", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BHJ9", "url": "https://www.orthodb.org/?gene=E1BHJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16483", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16483", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHJ9", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHJ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKILVVFLVALAIFGTQSLGNEVYNIISPTDKGGQIQETMTIDNENNAAIINIHAGSCSSTTIFDYKHGYIALRVLSRRACYILKMDHKAIPALDQLKRYIFERKALNSMFSDKYIWVKYNPLKSLITHVDWILFGSPIRQLCEHVPLYQGEVADKTHNTGAGVCAKAGLLGILGISVCADVHV", "length": 184, "header": "tr|E1BHJ9-1|E1BHJ9_BOVIN Isoform 1 of Gastrokine-2 OS=Bos taurus OX=9913 GN=GKN2 PE=4 SV=3 CANONICAL=E1BHJ9-1" }, "isoforms": [ { "isoform_ac": "E1BHJ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9/entry#E1BHJ9-1", "sequence": { "sequence": "MKILVVFLVALAIFGTQSLGNEVYNIISPTDKGGQIQETMTIDNENNAAIINIHAGSCSSTTIFDYKHGYIALRVLSRRACYILKMDHKAIPALDQLKRYIFERKALNSMFSDKYIWVKYNPLKSLITHVDWILFGSPIRQLCEHVPLYQGEVADKTHNTGAGVCAKAGLLGILGISVCADVHV", "length": 184, "header": "tr|E1BHJ9-1|E1BHJ9_BOVIN Isoform 1 of Gastrokine-2 OS=Bos taurus OX=9913 GN=GKN2 PE=4 SV=3 CANONICAL=E1BHJ9-1" }, "locus": { "chromosome": "11", "start_pos": 67294237, "end_pos": 67286587, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022857.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022857.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022857.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022857.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512001", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512001", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ9", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" } ], "pmid": "" }, { "name": "basal part of cell", "id": "GO:0045178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045178", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ9", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ9", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHJ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHJ9" }, { "id": "PS50869", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50869" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRICHOS", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 151, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHM2-1", "uniprot_ac": "E1BHM2", "uniprot_id": "E1BHM2_BOVIN", "mass": { "chemical_mass": 26004.0, "monoisotopic_mass": 26004.0 }, "refseq": { "ac": "NP_001193106", "name": "uncharacterized protein C9orf152 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193106" }, "gene_names": [ { "name": "C8H9orf152", "type": "recommended", "evidence": [ { "id": "E1BHM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM2" } ] }, { "name": "C8H9orf152", "type": "synonym", "evidence": [ { "id": "NP_001193106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193106" } ] } ], "protein_names": [ { "name": "Chromosome 8 C9orf152 homolog", "type": "synonym", "evidence": [ { "id": "E1BHM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM2/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C9orf152 homolog", "type": "synonym", "evidence": [ { "id": "NP_001193106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193106" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHM2", "url": "https://www.uniprot.org/uniprotkb/E1BHM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C8H9orf152", "url": "https://www.uniprot.org/uniprotkb/E1BHM2", "locus": { "chromosome": "8", "start_pos": 99746343, "end_pos": 99753473, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003240", "url": "https://www.ensembl.org/id/ENSBTAG00000003240" } ] } } ], "crossref": [ { "id": "E1BHM2", "url": "https://alphafold.ebi.ac.uk/entry/E1BHM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003240", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003240", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614478", "url": "https://www.ncbi.nlm.nih.gov/gene/614478", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614478", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614478", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVNAVWI", "url": "https://omabrowser.org/oma/group/MVNAVWI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHM2", "url": "https://www.orthodb.org/?gene=E1BHM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36290:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36290:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15733", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15733", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHM2", "url": "https://www.uniprot.org/uniprotkb/E1BHM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGLPCPCPALPHFWQLGSCYMAEGSGPPAPRKGPLLNIQLLRAQYEGLRRKQRAQAHVVVLPKGGNLPAPAESMVSAVWINKERRHSLTPEEAAPEAEEMLEEDDRGCLQTPESPWHTHLEMHRLVQTFRQGTSLHVRHKDKFTGSEPRLPGLFEDTQMTQQETTIPETAQPECQADESQTKTVGSGFHVGTQGPPAIKRPHRAGKPAHYPFPQRKTPRISQAARNLGLYGPV", "length": 234, "header": "tr|E1BHM2-1|E1BHM2_BOVIN Isoform 1 of Chromosome 8 C9orf152 homolog OS=Bos taurus OX=9913 GN=C8H9orf152 PE=4 SV=3 CANONICAL=E1BHM2-1" }, "isoforms": [ { "isoform_ac": "E1BHM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHM2/entry#E1BHM2-1", "sequence": { "sequence": "MKGLPCPCPALPHFWQLGSCYMAEGSGPPAPRKGPLLNIQLLRAQYEGLRRKQRAQAHVVVLPKGGNLPAPAESMVSAVWINKERRHSLTPEEAAPEAEEMLEEDDRGCLQTPESPWHTHLEMHRLVQTFRQGTSLHVRHKDKFTGSEPRLPGLFEDTQMTQQETTIPETAQPECQADESQTKTVGSGFHVGTQGPPAIKRPHRAGKPAHYPFPQRKTPRISQAARNLGLYGPV", "length": 234, "header": "tr|E1BHM2-1|E1BHM2_BOVIN Isoform 1 of Chromosome 8 C9orf152 homolog OS=Bos taurus OX=9913 GN=C8H9orf152 PE=4 SV=3 CANONICAL=E1BHM2-1" }, "locus": { "chromosome": "8", "start_pos": 99752613, "end_pos": 99747614, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004199.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004199.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004199.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004199.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614478", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614478", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A4N9-1", "protein_name": "Similar to human chromosome 9 open reading frame 152", "gene_name": "C5h9orf152", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRMKGLACPCPALPKFLELGTSLMAEGSRAQASGQGPPINIQFLRAQYEGLKRQQRTQAHLMVFPKEGIMPAPAELMTSTVWINKERRSSLSPEETDSEAEGMLEEADRSCRQAPWHTYLELHRLVQTFHLEAGHQGNPKGYLVEPEPRLSPEGDTDVLKSSQKTHQEIKISEVAQRQGQGDRAPLQVAGSSAQGLASTKNLHRSGKPAHYPFPQRKPPRISQAARNLGLYGPP", "length": 234 }, "evidence": [ { "id": "E1BHM2", "url": "https://omabrowser.org/oma/group/E1BHM2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SP05-1", "protein_name": "Chromosome 1 C9orf152 homolog", "gene_name": "C9orf152", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKGLPCPCPALPHFWQLGSHFMAEGSGTQAPGKGPLLSVQLLRAQYEGLRRQQKAQAHVVVLQKGGNIPAPAESVVSAVWINKERRHSLSLEEADSEPEGMLEEADRGSLWTSESPWHTHLEMYRLVQTFRQETSHQVKHKDKFVGPEQRLPQEGDTGLSEDSQMTQQGIRMPEAAQPEGQVGDTQTEARGSSLNIGTQRPLSIKNPHRSGKPAHYPFPRKKTPRISQAARNLGLYGPA", "length": 239 }, "evidence": [ { "id": "E1BHM2", "url": "https://omabrowser.org/oma/group/E1BHM2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5JTZ5-1", "protein_name": "Uncharacterized protein C9orf152", "gene_name": "C9orf152", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGLPCPCPALPHFWQLRSHLMAEGSRTQAPGKGPPLSIQFLRAQYEGLKRQQRTQAHLLVLPKGGNTPAPAESMVNAVWINKERRSSLSLEEADSEVEGRLEEAAQGCLQAPKSPWHTHLEMHCLVQTSPQDTSHQVHHRGKLVGSDQRLPPEGDTHLFETNQMTQQGTGIPEAAQLPCQVGNTQTKAVESGLKFSTQCPLSIKNPHRSGKPAYYPFPQRKTPRISQAARNLGLYGSA", "length": 239 }, "evidence": [ { "id": "E1BHM2", "url": "https://omabrowser.org/oma/group/E1BHM2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHM2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHM2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHM2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM2" }, { "id": "PF15733", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15733" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TBC1", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 152, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHM5-1", "uniprot_ac": "E1BHM5", "uniprot_id": "E1BHM5_BOVIN", "mass": { "chemical_mass": 100155.0, "monoisotopic_mass": 100155.0 }, "refseq": {}, "gene_names": [ { "name": "RBM25", "type": "recommended", "evidence": [ { "id": "E1BHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ] } ], "protein_names": [ { "name": "RNA-binding protein 25", "type": "recommended", "evidence": [ { "id": "E1BHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM5/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 25", "type": "synonym", "evidence": [ { "id": "E1BHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM25", "url": "https://www.uniprot.org/uniprotkb/E1BHM5", "locus": { "chromosome": "10", "start_pos": 84608403, "end_pos": 84561433, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017177", "url": "https://www.ensembl.org/id/ENSBTAG00000017177" } ] } } ], "crossref": [ { "id": "E1BHM5", "url": "https://alphafold.ebi.ac.uk/entry/E1BHM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12446", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12446", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DGCVNKK", "url": "https://omabrowser.org/oma/group/DGCVNKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHM5", "url": "https://www.orthodb.org/?gene=E1BHM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18806:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18806:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNAAKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 843, "header": "tr|E1BHM5-1|E1BHM5_BOVIN Isoform 1 of RNA-binding protein 25 OS=Bos taurus OX=9913 GN=RBM25 PE=4 SV=2 CANONICAL=E1BHM5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8C9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHM5/entry#A0AAA9S8C9-1", "sequence": { "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKRSYGD", "length": 294, "header": "tr|A0AAA9S8C9-1|A0AAA9S8C9_BOVIN Computationally mapped isoform of RNA binding motif protein 25 OS=Bos taurus OX=9913 GN=RBM25 PE=4 SV=1 CANONICAL=E1BHM5-1" }, "locus": { "chromosome": "10", "start_pos": 84589624, "end_pos": 84568244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122975.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122975.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081505.1" } ] } }, { "isoform_ac": "E1BHM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHM5/entry#E1BHM5-1", "sequence": { "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNAAKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 843, "header": "tr|E1BHM5-1|E1BHM5_BOVIN Isoform 1 of RNA-binding protein 25 OS=Bos taurus OX=9913 GN=RBM25 PE=4 SV=2 CANONICAL=E1BHM5-1" }, "locus": { "chromosome": "10", "start_pos": 84607399, "end_pos": 84568244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022826.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022826.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022826.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022826.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GMR5-1", "protein_name": "RNA-binding protein 25", "gene_name": "Rbm25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDRQRKEGLCQLLWTGAVRMSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKLKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKANGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPVEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNAAKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 855 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZFJ7-1", "protein_name": "RNA-binding protein 25", "gene_name": "RBM25", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSFPPHLNRPPMGIPTLPPGIPPPQFPGFPPPVPPGTPMIPVPMGIMAPAPTVLVPTTVSMVGKHLGVRKDHPGLKNKENDENSGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNSRPETTNDDDEALDEETKRRDQIIKGAIDVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKDRDRDRERDRDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKSREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKAEKEEKREEPEEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGACNSPNQPNAVKRKKLAVDSVFNKFDDEDSDDVPRKRKLVPLDYGDEDKSNIKGSVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSTLMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 835 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JSS4-1", "protein_name": "RNA-binding protein 25", "gene_name": "Rbm25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDRQRKEGLCQLLWTGAVRMSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKLKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGSARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 858 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A8DZA0-1", "protein_name": "RNA-binding protein 25b isoform X1", "gene_name": "rbm25b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSFPPHLNRPQIGIPTLPPGIPPPQFAGFPPTMPPGTPMIPVHMGIMAPAPAVLVPTTMSVVSKVAAPRKESIAAHAKDDDSSGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHELQVGEKKLLVKVDAKTKAQLDEWKAKKKSTSANGNGKADDAGEEEEEVLDEETKKRDQIVKGAIDGLIREYSSELNAQSQDDESSRRKKKREKKDEDDINAMEMEDDKRDLISREINKFRDTHKKLEEEKGKREKERQELERERKERDKERERERERRDREREKERERERERERERERERDRDRERTKERDRDRDWERDRSRDRSEGRSRSREQSRDRERDKDKKRDREEDEEEAYERRKLERKLREKEAAYQERLKNWELRERKKARDYSKEIEREEERRREMAKEGKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEIELDERDRKREKEELEEIRQRLLAEGHPDPDAELRRMEEEAERLRQPPVKPEPEEEREHKPSREERDRERGRDRDRRKAPVETHTHVHAHVHTHVHANIPSDDDVEEGEEIEDEEEPKPCLKPTMRPITAAPSVSSASGNATPNTPREESPCGIIIPHENSPQEMLLPEENRPKIGLSLKLGSSGSPGQPSVAKRKKLPVESVFNRFDDDEVDEAPRKRKLVPLDYEDEEKAVDGATVAGGKGVNTEEKRKHIKSLIEKIPTAKPELFNYPLDWSVVDTALMEKRIRPWINKKIVEYIGEEEATLVDFVCSKVMAHSTPQGILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLGK", "length": 830 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B2RY56-1", "protein_name": "RNA-binding protein 25", "gene_name": "Rbm25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKLKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKANGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPVEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 838 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49756-1", "protein_name": "RNA-binding protein 25", "gene_name": "RBM25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "length": 843 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VY15-1", "protein_name": "RNA-binding motif protein 25", "gene_name": "RBM25", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADESSSPATGDPNSQKPESTTPISIPNPNPNPSLTPPPPQQHSQPPVAPLVPPGPPYAPPAQIPSSLLPTNLPPPPPFRPGMQFTPVANFQNPSSGVPPPGSMPQYQPQPGMRPFQPMANGYPGIHGVAPPGAMPPHGLLRYPSPYPTMVRPGFIMRPPGTIGAVQLAPRPLIPGMPGLRPVMPPMVRPASLPFVTPAEKPQTTIYIGKIATVENDFMMSILEFCGHVKSCLRAEDPTTKKPKGFGFYEFESAEGILRAIRLLTQRTIDGQELLVNVNQATKEYLLKYVEKKIETAKKAKESQGTKENQAEGPESEQDKLESADNETGKDGESKIKENIDIANSAVLTDEEREADREAMEKIETAIEERLKSNPLPPPPPPPADGSGMEFAFKSKDGDSNTDVARSDAAANDVETSGEHNRPDTSSPDWSKRNDRRSRERGEKEQEMDRYEREAERERSRKEREQRRKLEDAERAYQTRLRQWERREREKEKERQYEKEKEKEKERKRKKEIRYEEEEEEDDDDSRRRWHRAALDERRRRQLREKEDDLADRLKEEEEVAEAKRSAEEQNLQQQQLDALRILSGQAAIGSETVQTSPIENDHKATLQTVGESANEHHAADFEENGSGNESMAIDNNSGSEAHAPSKKLGFGLVGSGKRTSVPSVFYEEDEDEARKAKKMKPLVPIDYSTEEQEAVAHGGSGNTPPHLALAAEFAKRISSTNPKEETIETEKQRSRRSHDKASHRDRERERERDRDRDRVRDRGDGHSGPTKDAKESGKAKIIDTKFLDAKQLIDTIPKTKEDLFSYEINWAMYDKHQVHERMRPWISKKIMEFLGEEEATLVDFIVSNTQQHVQASQMLELLQSILDEEAEMFVLKMWRMLIFEIKRVEAGVPVKSKA", "length": 899 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V3Y5-1", "protein_name": "Uncharacterized protein", "gene_name": "BcDNA.LD23634", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSYPPRAPMPPFMNTAIPPPHIMQNMAKPPRSFRNSATISSQPTVYQRPPEPQPQFRGPIITVFVGNISERVPEALLKRILNACGVVINWKRVSTFGFCEFDGPIAAMRAVRLLSEMEIDGKKLVAKVDAKNKVLIEDYKEQECKNGDRSNPVDEKTEDEFAIAQMHEFLEEHKHEFEGFDSSSRADLYGSANRNKKTRREEDIKMKVLSENTLEEEKRNLISSEIGKFRMRAEEDEHRKELEKEKEKEKLAASKEKERKKQREMERMSSTSKSGSSSTAAASSSSATATSSTPAADGADMSDKTDKESVAVVIKETVKESKESASSTGRKESSSAAIEITQKERRSDSKETRRRRSKSRSKDRERERERELRELRDKERERERDRERERERERNEMRERERNEMREREREREREREREEKLLKPVRDTWREKEMEDELRDRKKAEKKAREKEIAYQTRLTDWEVREKRKAKENEKYRLKELLRQEERETDAKRLKEFVEDYDDERDDSLYYRGRELQQRLAERVREADADSKDREKEAEELAELKSKFFSGEYENPSLEFEKARLEIEKLYEPRILINVNQEPPAAATSSVHQRKQAASAPGEDDEGQKQRQKSQQLDSYDPDMAGTNDDDSISNDDRASMADTASNASGVYAKNNNNDQSLSNSLSRHNSESRDSLAQIHTPTQSAILNDQESGHDAILPSATPPMTMPLISLTLGNNLKKKKIEATGVFVNDDDNDENINPKKRKLVPLDYDDNISNTTPSNHAASSGSGAANNSSSSNNNNSSSADRQSSAVSAATAAAAAVSQKIAQAFGGGSSGSGSGSGSGSNASGGKNNGGGSSSSSNNKHNSNSKHGKNEAAASAGSSADAAAANIKKDENGAKVYDEKRRHIKSIIDRIPTQKEELFNYKLDRNEIDSGLMERKIRPWINKKIIEYIGEPEPTLVDFICSKVLAGSPPQSILDDVQMVLDEEAEVFVVKMWRLLIYELDAKKSGLAGK", "length": 998 }, "evidence": [ { "id": "E1BHM5", "url": "https://omabrowser.org/oma/group/E1BHM5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "E1BHM5", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 843, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHM5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" }, { "id": "PS51025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PWI", "eco_id": "ECO_0000259", "start_pos": 750, "end_pos": 843, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHM5" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 164, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 632, "end_pos": 634 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHN1-1", "uniprot_ac": "E1BHN1", "uniprot_id": "E1BHN1_BOVIN", "mass": { "chemical_mass": 14084.0, "monoisotopic_mass": 14084.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BHN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHN1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BHN1", "locus": {} } ], "crossref": [ { "id": "E1BHN1", "url": "https://alphafold.ebi.ac.uk/entry/E1BHN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006514", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006514", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BHN1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHN1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQSVTQPEAEVPVSEGDPVTVKCTYSVSGSPYLFWYVQHHNQGLQFLLKYIGGDSLVKGNYGFEAECNKSQTSFHLKKPSVVGSDSALYFCAVRDTVVGAAGRAEYKPLSTENRTPEALVSLHKVAVWL", "length": 129, "header": "tr|E1BHN1-1|E1BHN1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BHN1-1" }, "isoforms": [ { "isoform_ac": "E1BHN1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1/entry#E1BHN1-1", "sequence": { "sequence": "AQSVTQPEAEVPVSEGDPVTVKCTYSVSGSPYLFWYVQHHNQGLQFLLKYIGGDSLVKGNYGFEAECNKSQTSFHLKKPSVVGSDSALYFCAVRDTVVGAAGRAEYKPLSTENRTPEALVSLHKVAVWL", "length": 129, "header": "tr|E1BHN1-1|E1BHN1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BHN1-1" }, "locus": { "chromosome": "10", "start_pos": 25453993, "end_pos": 25453607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008541.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008541.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008541.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008541.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "E1BHN1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1" } ], "pmid": "" }, { "name": "immunoglobulin complex", "id": "GO:0019814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019814", "evidence": [ { "database": "UniProtKB", "id": "E1BHN1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "E1BHN1", "url": "https://www.uniprot.org/uniprotkb/E1BHN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHN1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 129, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHN1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHN1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHN1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 110, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHP1-1", "uniprot_ac": "E1BHP1", "uniprot_id": "E1BHP1_BOVIN", "mass": { "chemical_mass": 95385.0, "monoisotopic_mass": 95385.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC110", "type": "recommended", "evidence": [ { "id": "E1BHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP1" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 110", "type": "synonym", "evidence": [ { "id": "E1BHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHP1", "url": "https://www.uniprot.org/uniprotkb/E1BHP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC110", "url": "https://www.uniprot.org/uniprotkb/E1BHP1", "locus": { "chromosome": "27", "start_pos": 15691913, "end_pos": 15704480, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017157", "url": "https://www.ensembl.org/id/ENSBTAG00000017157" } ] } } ], "crossref": [ { "id": "E1BHP1", "url": "https://alphafold.ebi.ac.uk/entry/E1BHP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017157", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017157", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "E1BHP1", "url": "https://www.orthodb.org/?gene=E1BHP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32083:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32083:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1BHP1", "url": "https://www.uniprot.org/uniprotkb/E1BHP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AEKRPEEEDEVDCVLLSASKILNSSEGIKENGSSETEHGCVSESENQIQPQSALKALQQQLESFQALRIQTLQNVSMVQSEISEILNKSIIEVENPQFNPEKNLVFGTHNETALPIENQEETLSTEKIHHFEDSRTLHSAEEKFSSDSIDSLPQSIDVPCQIHFKDTLPLRISTDNSASENSDGLKNYNNFYNFLPNVPQNGMSQAETLILDKSRMTMPFLKNGFCENLDDICHSIKQMKEELQKSHNRELALTNELQTLKAVPRHGNYDLPPVHKEKNNFIKEENIESNLSEDIKSKRILELEALVNKLLPLRETVSKFHVNFCRKCKKLSRSEIHRGKRNEKNNKEIPITDKNIADLKLHSRVPRHTLAFIDPTKYEMKDKEKQPFTVKQGSIIFENEKTSKVNSVTEQCVAKIQYLQNYLKESMQIQKKVMKLENENLTLKTKIKPLVFTTQSLIQKIEMYEKQLKTLVEEKNTLQSKLTKTEEDGKECLKELKKIVSNYNVLQGQNKTLEEKNSQLSLENQQIIEALDQLKSKEHKTQSDMAIVNNENKRLSIEMESMKTNILLIQEEKEMLEKKTHQLLKEKGALENELKETRLETAQLKEKERLAKIEQETLLQIVETVKNEKLNLETTLQESTAAREMMAREIEDIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEMGNECELLSKMLMEIKTDNQLLKEELKKNSQESIKFENSISRLEEDKILLENYVRSIENERDTLEFEMRNLQREYSNLSEKICSHHIDLSKMGHISRKDKFHFDIYDIYEDTSSPGNRPLALGLKGTASKLYQLLPSKTCK", "length": 825, "header": "tr|E1BHP1-1|E1BHP1_BOVIN Isoform 1 of Coiled-coil domain containing 110 OS=Bos taurus OX=9913 GN=CCDC110 PE=4 SV=4 CANONICAL=E1BHP1-1" }, "isoforms": [ { "isoform_ac": "E1BHP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHP1/entry#E1BHP1-1", "sequence": { "sequence": "AEKRPEEEDEVDCVLLSASKILNSSEGIKENGSSETEHGCVSESENQIQPQSALKALQQQLESFQALRIQTLQNVSMVQSEISEILNKSIIEVENPQFNPEKNLVFGTHNETALPIENQEETLSTEKIHHFEDSRTLHSAEEKFSSDSIDSLPQSIDVPCQIHFKDTLPLRISTDNSASENSDGLKNYNNFYNFLPNVPQNGMSQAETLILDKSRMTMPFLKNGFCENLDDICHSIKQMKEELQKSHNRELALTNELQTLKAVPRHGNYDLPPVHKEKNNFIKEENIESNLSEDIKSKRILELEALVNKLLPLRETVSKFHVNFCRKCKKLSRSEIHRGKRNEKNNKEIPITDKNIADLKLHSRVPRHTLAFIDPTKYEMKDKEKQPFTVKQGSIIFENEKTSKVNSVTEQCVAKIQYLQNYLKESMQIQKKVMKLENENLTLKTKIKPLVFTTQSLIQKIEMYEKQLKTLVEEKNTLQSKLTKTEEDGKECLKELKKIVSNYNVLQGQNKTLEEKNSQLSLENQQIIEALDQLKSKEHKTQSDMAIVNNENKRLSIEMESMKTNILLIQEEKEMLEKKTHQLLKEKGALENELKETRLETAQLKEKERLAKIEQETLLQIVETVKNEKLNLETTLQESTAAREMMAREIEDIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEMGNECELLSKMLMEIKTDNQLLKEELKKNSQESIKFENSISRLEEDKILLENYVRSIENERDTLEFEMRNLQREYSNLSEKICSHHIDLSKMGHISRKDKFHFDIYDIYEDTSSPGNRPLALGLKGTASKLYQLLPSKTCK", "length": 825, "header": "tr|E1BHP1-1|E1BHP1_BOVIN Isoform 1 of Coiled-coil domain containing 110 OS=Bos taurus OX=9913 GN=CCDC110 PE=4 SV=4 CANONICAL=E1BHP1-1" }, "locus": { "chromosome": "27", "start_pos": 15704480, "end_pos": 15691916, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022809.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022809.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022809.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022809.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BHP1", "url": "https://www.uniprot.org/uniprotkb/E1BHP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 825, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHP1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 440, "end_pos": 442 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 74, "end_pos": 76 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHP7-1", "uniprot_ac": "E1BHP7", "uniprot_id": "E1BHP7_BOVIN", "mass": { "chemical_mass": 38413.0, "monoisotopic_mass": 38413.0 }, "refseq": { "ac": "NP_001192661", "name": "integrin beta-1-binding protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192661" }, "gene_names": [ { "name": "ITGB1BP2", "type": "recommended", "evidence": [ { "id": "E1BHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ] }, { "name": "ITGB1BP2", "type": "synonym", "evidence": [ { "id": "NP_001192661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192661" } ] } ], "protein_names": [ { "name": "Integrin beta-1-binding protein 2", "type": "recommended", "evidence": [ { "id": "E1BHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP7/entry#names_and_taxonomy" } ] }, { "name": "Melusin", "type": "synonym", "evidence": [ { "id": "E1BHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP7/entry#names_and_taxonomy" } ] }, { "name": "integrin beta 1 binding protein (melusin) 2", "type": "synonym", "evidence": [ { "id": "NP_001192661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192661" } ] }, { "name": "integrin beta-1-binding protein 2", "type": "synonym", "evidence": [ { "id": "NP_001192661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192661" } ] } ], "function": [ { "annotation": "May play a role during maturation and/or organization of muscles cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7#function" }, { "database": "UniProtKB", "id": "ARBA00054289", "url": "https://www.uniprot.org/uniprotkb/ARBA00054289#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITGB1BP2", "url": "https://www.uniprot.org/uniprotkb/E1BHP7", "locus": { "chromosome": "X", "start_pos": 79363943, "end_pos": 79367501, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012163", "url": "https://www.ensembl.org/id/ENSBTAG00000012163" } ] } } ], "crossref": [ { "id": "E1BHP7", "url": "https://alphafold.ebi.ac.uk/entry/E1BHP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012163", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012163", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06488", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06488", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539945", "url": "https://www.ncbi.nlm.nih.gov/gene/539945", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539945", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539945", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCQKRTV", "url": "https://omabrowser.org/oma/group/CCQKRTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M676", "url": "https://www.orthodb.org/?gene=A0A3Q1M676", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BHP7", "url": "https://www.orthodb.org/?gene=E1BHP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46983:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46983:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04968", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04968", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04969", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04969", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M676", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M676", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M676-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M676-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHP7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLLCHNKGCGQHFDPQTNLPDSCYHHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPGTSSSLQEQRPPNVIPKSAETLRRERPKSELLPKLLPLNISQALEMALEQKELDQEPGAGVDSSLIRIGASCQNPGCDAVYQGLESDATPCTYHPGAPQFHEGVKSWSCCGIQTLDFGAFLAQPGCRVGRHDWGKQVPASCRHDWHQTDSLVVVTIYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVIDVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDALAEKAKAKVGLEMDEEESEDSDDDLSWTEEEEEEEAMGE", "length": 348, "header": "tr|E1BHP7-1|E1BHP7_BOVIN Isoform 1 of Integrin beta-1-binding protein 2 OS=Bos taurus OX=9913 GN=ITGB1BP2 PE=4 SV=1 CANONICAL=E1BHP7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M676-1", "url": "https://www.uniprot.org/uniprotkb/E1BHP7/entry#A0A3Q1M676-1", "sequence": { "sequence": "VSTDSCYHHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPGTSSSLQEQRPPNVIPKSAETLRRERPKSELLPKLLPLNISQALEMALEQKELDQEPGAGVDSSLIRIGASCQNPGCDAVYQGLESDATPCTYHPGAPQFHEGVKSWSCCGIQTLDFGAFLAQPGCRVGRHDWGKQVPASCRHDWHQTDSLVVVTIYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVIDVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDALAEKAKAKVGLEMDEEESEDSDDDLSWTEEEEEEEAMGE", "length": 330, "header": "tr|A0A3Q1M676-1|A0A3Q1M676_BOVIN Computationally mapped isoform of Integrin subunit beta 1 binding protein 2 OS=Bos taurus OX=9913 GN=ITGB1BP2 PE=4 SV=2 CANONICAL=E1BHP7-1" }, "locus": { "chromosome": "X", "start_pos": 79367185, "end_pos": 79364115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083605.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083605.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069217.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069217.2" } ] } }, { "isoform_ac": "E1BHP7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHP7/entry#E1BHP7-1", "sequence": { "sequence": "MSLLCHNKGCGQHFDPQTNLPDSCYHHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPGTSSSLQEQRPPNVIPKSAETLRRERPKSELLPKLLPLNISQALEMALEQKELDQEPGAGVDSSLIRIGASCQNPGCDAVYQGLESDATPCTYHPGAPQFHEGVKSWSCCGIQTLDFGAFLAQPGCRVGRHDWGKQVPASCRHDWHQTDSLVVVTIYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVIDVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDALAEKAKAKVGLEMDEEESEDSDDDLSWTEEEEEEEAMGE", "length": 348, "header": "tr|E1BHP7-1|E1BHP7_BOVIN Isoform 1 of Integrin beta-1-binding protein 2 OS=Bos taurus OX=9913 GN=ITGB1BP2 PE=4 SV=1 CANONICAL=E1BHP7-1" }, "locus": { "chromosome": "X", "start_pos": 79367480, "end_pos": 79364115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016136.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016136.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016136.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016136.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539945", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539945", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HUX1-1", "protein_name": "Integrin beta-1-binding protein 2", "gene_name": "Itgb1bp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLLCHNKGCGQHFDPNTNLPDSCHYHSGVPIFHDALKGWSCCRKRTVDFSEFLNIEGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRERPKSEMPPKLLPLIISQALGVALEQKELDQEPGAGLDSSLIWTGSSCQNPGCDAVYQGPESDAAPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLTQPGCRVGRHDWAKHLPASCRHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTELQVHVVFDGNRVFQAQMKLWGVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEGSDDDLSWTEEEEEEEEEEEAMGE", "length": 351 }, "evidence": [ { "id": "E1BHP7", "url": "https://omabrowser.org/oma/group/E1BHP7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZW59-1", "protein_name": "Integrin beta-1-binding protein 2", "gene_name": "Itgb1bp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASCRHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLSWTEEEDEDEEEAMGE", "length": 349 }, "evidence": [ { "id": "E1BHP7", "url": "https://omabrowser.org/oma/group/E1BHP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LGH0-1", "protein_name": "Integrin subunit beta 1 binding protein 2", "gene_name": "ITGB1BP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGIVTFPSLILLLISTDSCCHHPGVPVFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEAPQPEGPATSSSLLEQKPPNTIPKSAETLRRERPKSDLPPKLLPLNISQALEMALEQKELDQEPGAGLDSSLIQTGASCQNPGCDAVYQGSESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGVFLAQPGCRVGRHDWGKKLLASCRHDWHQTDSLVVVTVYGQIPLPAFNWVKASQTELHIHIVFDGNRVFQAQMKLWGVVNVEQSSVSLMPSRVEISLVKADPGFWAQLEHPDALAEKSKSGVGLEMDEEESEDSDDDLSWTEEEEEAMGE", "length": 342 }, "evidence": [ { "id": "E1BHP7", "url": "https://omabrowser.org/oma/group/E1BHP7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9R000-1", "protein_name": "Integrin beta-1-binding protein 2", "gene_name": "Itgb1bp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGLHCAEKLPEVPPQPEGPATSSLQEQKPLNTIPKSAETLFRERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASCRHDWHQTDSVVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLSWTEEEDEEEEEAMGE", "length": 350 }, "evidence": [ { "id": "E1BHP7", "url": "https://omabrowser.org/oma/group/E1BHP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "centrosome duplication", "id": "GO:0051298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", "evidence": [ { "database": "UniProtKB", "id": "E1BHP7", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 348, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHP7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" }, { "id": "PS51401", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51401" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHORD", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 64, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHP7" }, { "id": "PS51203", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51203" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CS", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 305, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHQ2-1", "uniprot_ac": "E1BHQ2", "uniprot_id": "E1BHQ2_BOVIN", "mass": { "chemical_mass": 40621.0, "monoisotopic_mass": 40621.0 }, "refseq": {}, "gene_names": [ { "name": "SELENOV", "type": "recommended", "evidence": [ { "id": "E1BHQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2" } ] } ], "protein_names": [ { "name": "Selenoprotein V", "type": "synonym", "evidence": [ { "id": "E1BHQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHQ2", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SELENOV", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2", "locus": { "chromosome": "18", "start_pos": 49190099, "end_pos": 49184821, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010501", "url": "https://www.ensembl.org/id/ENSBTAG00000010501" } ] } } ], "crossref": [ { "id": "E1BHQ2", "url": "https://alphafold.ebi.ac.uk/entry/E1BHQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010501", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010501", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15124:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15124:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10262", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10262", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BHQ2", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNQPRTPAPTPARASTPVRGSTLHRTSIQVRTPTPGPDSGPTRITTLLRTPALIRTLTPIRTPTPVRTPTPVPPSTPVRSPIPVRTPTPVPPSTPVRTPTPVPLSTPVRPPTPVRPPTPVRPPTPVRPPTPIGTPTLIRSPTPVQIPIPEPIPTPIPSRVLIPPLESFPDSALPSGPPLELEPTLTVSPAKNLEPSPAKNLEPSPRVKQVSSAANGFPPIQEPLPALTPLATDLRSPSLGSPLRTDTSTTNLIASSSGHVPGTPILGAIQAILPVPATALASISGNLKEENKIMIRVVYCGIFVSMTRYILLRKSLEQQFPNSLIFEEEISAQATGEFEVFVDGKLIHSKKNGDGFVDEVKLQTIVNLLNEEFKKKVAGN", "length": 381, "header": "tr|E1BHQ2-1|E1BHQ2_BOVIN Isoform 1 of Selenoprotein V OS=Bos taurus OX=9913 GN=SELENOV PE=4 SV=4 CANONICAL=E1BHQ2-1" }, "isoforms": [ { "isoform_ac": "E1BHQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2/entry#E1BHQ2-1", "sequence": { "sequence": "MNNQPRTPAPTPARASTPVRGSTLHRTSIQVRTPTPGPDSGPTRITTLLRTPALIRTLTPIRTPTPVRTPTPVPPSTPVRSPIPVRTPTPVPPSTPVRTPTPVPLSTPVRPPTPVRPPTPVRPPTPVRPPTPIGTPTLIRSPTPVQIPIPEPIPTPIPSRVLIPPLESFPDSALPSGPPLELEPTLTVSPAKNLEPSPAKNLEPSPRVKQVSSAANGFPPIQEPLPALTPLATDLRSPSLGSPLRTDTSTTNLIASSSGHVPGTPILGAIQAILPVPATALASISGNLKEENKIMIRVVYCGIFVSMTRYILLRKSLEQQFPNSLIFEEEISAQATGEFEVFVDGKLIHSKKNGDGFVDEVKLQTIVNLLNEEFKKKVAGN", "length": 381, "header": "tr|E1BHQ2-1|E1BHQ2_BOVIN Isoform 1 of Selenoprotein V OS=Bos taurus OX=9913 GN=SELENOV PE=4 SV=4 CANONICAL=E1BHQ2-1" }, "locus": { "chromosome": "18", "start_pos": 49187763, "end_pos": 49184821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055738.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055738.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050911.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050911.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 11, "start_aa": "Thr", "end_pos": 11, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr11", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BHQ2", "url": "https://www.uniprot.org/uniprotkb/E1BHQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHQ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHQ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHQ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 11, 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHR5-1", "uniprot_ac": "E1BHR5", "uniprot_id": "E1BHR5_BOVIN", "mass": { "chemical_mass": 129145.0, "monoisotopic_mass": 129145.0 }, "refseq": {}, "gene_names": [ { "name": "HEATR6", "type": "recommended", "evidence": [ { "id": "E1BHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHR5" } ] } ], "protein_names": [ { "name": "HEAT repeat-containing protein 6", "type": "recommended", "evidence": [ { "id": "E1BHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHR5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHR5", "url": "https://www.uniprot.org/uniprotkb/E1BHR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEATR6", "url": "https://www.uniprot.org/uniprotkb/E1BHR5", "locus": { "chromosome": "19", "start_pos": 14132719, "end_pos": 14165328, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009635", "url": "https://www.ensembl.org/id/ENSBTAG00000009635" } ] } } ], "crossref": [ { "id": "E1BHR5", "url": "https://alphafold.ebi.ac.uk/entry/E1BHR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052107", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052107", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BHR5", "url": "https://www.orthodb.org/?gene=E1BHR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13366:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13366:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02985", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02985", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13251", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13251", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BHR5", "url": "https://www.uniprot.org/uniprotkb/E1BHR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHR5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAQVVGSLPGGPPPETPGEPPFEQGRGFRCLSARLCALRPDDSSSGRTEIHLLFDQLISETYSEGCGVAPEVGPLDVSTLLVQACRLVPLNQNHLVSKLSQLIHHLLNTLQVIVDEQNLDFLLAYTISAIQQCSSWTHMQILQALAALVYCNGSKCQKYLPDLLGKSGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNICFQVFLTTLQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMKLTQTDELGALLAVLKKSMFHGLPGLNIEMPTVLYPTPLPQYDGRPPIQPQQSESSTSRPAVNKKKKSKVKAKKIQQGEEEEEESSGEREVAPVAGAGRLNLHRGDTQCPSPPGAQSLPLAASGAAGKDRVSSPFSSSSWKRVSSSESDYSDAEGGMQNKVRSYQARVRQGALACFLSTIKSIEKRVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPRTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVMIASSIKELHRCLLLALVAESSSQTLTQIIKCLANLVSNSPYNRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLSGSSSATPHLSPPEWWKKAPSGPFVEEGAVSSPKLSSEPCWLIRLCISIVVLPREDSCSGSDAGSAGGSIYEPFPMRLEALQVLAHLARGYFSMTQVYLMELGEVICKCLGEADPSIQLHGAKLLEELGTSLIHQYKPDSSVAPDQRVPVPLVVTFWTAMLNGPLPRALQNAEHPTLQASACDALSSILPEAFGSLPSDRQILCITMLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSPNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLQSAIDASKDKDKVKSNAVRALGNLLHFLQPSHIEKPRFAEIIEEAIQALISTVLIEAAMKVRWNACYAMGNVFKNPALPLETAPWTSQAYDALTSVVTSCKNFKVRIRSAAALAVPRRREHYGSVEQYAQIWDALVTALQKSEDTTDFLEFKYCASLRTQICQALIHLLSLASPSDLSCIRKTLELHRDMVQSYILQFLKSGTERDDTGAPHHPQERDQMVRTALGHINSVQALAGDPAKRAIMAFLEDTLTIYSDSSGSQVAPLGLTHR", "length": 1185, "header": "tr|E1BHR5-1|E1BHR5_BOVIN Isoform 1 of HEAT repeat-containing protein 6 OS=Bos taurus OX=9913 GN=HEATR6 PE=4 SV=4 CANONICAL=E1BHR5-1" }, "isoforms": [ { "isoform_ac": "E1BHR5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHR5/entry#E1BHR5-1", "sequence": { "sequence": "MAAAQVVGSLPGGPPPETPGEPPFEQGRGFRCLSARLCALRPDDSSSGRTEIHLLFDQLISETYSEGCGVAPEVGPLDVSTLLVQACRLVPLNQNHLVSKLSQLIHHLLNTLQVIVDEQNLDFLLAYTISAIQQCSSWTHMQILQALAALVYCNGSKCQKYLPDLLGKSGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNICFQVFLTTLQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMKLTQTDELGALLAVLKKSMFHGLPGLNIEMPTVLYPTPLPQYDGRPPIQPQQSESSTSRPAVNKKKKSKVKAKKIQQGEEEEEESSGEREVAPVAGAGRLNLHRGDTQCPSPPGAQSLPLAASGAAGKDRVSSPFSSSSWKRVSSSESDYSDAEGGMQNKVRSYQARVRQGALACFLSTIKSIEKRVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPRTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVMIASSIKELHRCLLLALVAESSSQTLTQIIKCLANLVSNSPYNRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLSGSSSATPHLSPPEWWKKAPSGPFVEEGAVSSPKLSSEPCWLIRLCISIVVLPREDSCSGSDAGSAGGSIYEPFPMRLEALQVLAHLARGYFSMTQVYLMELGEVICKCLGEADPSIQLHGAKLLEELGTSLIHQYKPDSSVAPDQRVPVPLVVTFWTAMLNGPLPRALQNAEHPTLQASACDALSSILPEAFGSLPSDRQILCITMLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSPNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLQSAIDASKDKDKVKSNAVRALGNLLHFLQPSHIEKPRFAEIIEEAIQALISTVLIEAAMKVRWNACYAMGNVFKNPALPLETAPWTSQAYDALTSVVTSCKNFKVRIRSAAALAVPRRREHYGSVEQYAQIWDALVTALQKSEDTTDFLEFKYCASLRTQICQALIHLLSLASPSDLSCIRKTLELHRDMVQSYILQFLKSGTERDDTGAPHHPQERDQMVRTALGHINSVQALAGDPAKRAIMAFLEDTLTIYSDSSGSQVAPLGLTHR", "length": 1185, "header": "tr|E1BHR5-1|E1BHR5_BOVIN Isoform 1 of HEAT repeat-containing protein 6 OS=Bos taurus OX=9913 GN=HEATR6 PE=4 SV=4 CANONICAL=E1BHR5-1" }, "locus": { "chromosome": "19", "start_pos": 14165328, "end_pos": 14133119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012697.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012697.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012697.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012697.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 827, "end_pos": 829, "annotation": "n_glycosylation_sequon" }, { "start_pos": 886, "end_pos": 888, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHR5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHR5" }, { "id": "PF13251", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13251" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4042", "eco_id": "ECO_0000259", "start_pos": 422, "end_pos": 603, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 827, "end_pos": 829 }, { "start_pos": 886, "end_pos": 888 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHU4-1", "uniprot_ac": "E1BHU4", "uniprot_id": "E1BHU4_BOVIN", "mass": { "chemical_mass": 59746.0, "monoisotopic_mass": 59746.0 }, "refseq": {}, "gene_names": [ { "name": "LOC526757", "type": "recommended", "evidence": [ { "id": "E1BHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHU4", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC526757", "url": "https://www.uniprot.org/uniprotkb/E1BHU4", "locus": {} } ], "crossref": [ { "id": "E1BHU4", "url": "https://alphafold.ebi.ac.uk/entry/E1BHU4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037570", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037570", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BHU4", "url": "https://www.orthodb.org/?gene=E1BHU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BHU4", "url": "https://www.uniprot.org/uniprotkb/E1BHU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFEELLDKVGGLGKFQILQMALIFPSFMIVVCHSLLENFTAAVPGHRCWVHILDNATVSDNDTGILSPDVLLRISIPLDSNLKPEKCRRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVYDHSLVSSTIVTEWDLVCDQQSQKPLIQSLVMVGTLVGGLIYGHLSDRFGRKLILKWCLLQLPISGTCTSFAPNIFIYCLLRFLSGCSIAVIITNNCFLIIEWTRSQSKGMVLTLIYCALSIGQMMLGGLAFVFREWRTLQLVLSVPFFVFFLSSRWLVESSRWLIITSKPDKGLKELKIVAHRNGMKNAEEILNLEGLRATMQEELETAQTKTTMFDLFRTPNLRKRIYLLSLVRFAGTIPFFGIIVNLQHFGSNIFLFQVIFGALTISVRCLALYPLNNVGRRPTQMFFMFLVGLSILINMFVPQDMQILRVILASVGIGCAAASHTCFSVHQSELLPTIVRAKAAGLDLLANRCGAALAPLLMTLVVYLPTLPWIIYGVCPIIAVPVLLLLPETRNLPLPDTIQDVENK", "length": 533, "header": "tr|E1BHU4-1|E1BHU4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC526757 PE=4 SV=4 CANONICAL=E1BHU4-1" }, "isoforms": [ { "isoform_ac": "E1BHU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU4/entry#E1BHU4-1", "sequence": { "sequence": "MAFEELLDKVGGLGKFQILQMALIFPSFMIVVCHSLLENFTAAVPGHRCWVHILDNATVSDNDTGILSPDVLLRISIPLDSNLKPEKCRRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVYDHSLVSSTIVTEWDLVCDQQSQKPLIQSLVMVGTLVGGLIYGHLSDRFGRKLILKWCLLQLPISGTCTSFAPNIFIYCLLRFLSGCSIAVIITNNCFLIIEWTRSQSKGMVLTLIYCALSIGQMMLGGLAFVFREWRTLQLVLSVPFFVFFLSSRWLVESSRWLIITSKPDKGLKELKIVAHRNGMKNAEEILNLEGLRATMQEELETAQTKTTMFDLFRTPNLRKRIYLLSLVRFAGTIPFFGIIVNLQHFGSNIFLFQVIFGALTISVRCLALYPLNNVGRRPTQMFFMFLVGLSILINMFVPQDMQILRVILASVGIGCAAASHTCFSVHQSELLPTIVRAKAAGLDLLANRCGAALAPLLMTLVVYLPTLPWIIYGVCPIIAVPVLLLLPETRNLPLPDTIQDVENK", "length": 533, "header": "tr|E1BHU4-1|E1BHU4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC526757 PE=4 SV=4 CANONICAL=E1BHU4-1" }, "locus": { "chromosome": "29", "start_pos": 41458373, "end_pos": 41424874, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000676.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000676.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000676.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000676.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BHU4", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1BHU4", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "organic anion transport", "id": "GO:0015711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015711", "evidence": [ { "database": "UniProtKB", "id": "E1BHU4", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHU4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHU4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHU4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU4" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 519, "start_aa": "Trp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 107, "end_pos": 109 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHU7-1", "uniprot_ac": "E1BHU7", "uniprot_id": "E1BHU7_BOVIN", "mass": { "chemical_mass": 48969.0, "monoisotopic_mass": 48969.0 }, "refseq": { "ac": "NP_001179533", "name": "otolin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179533" }, "gene_names": [ { "name": "OTOL1", "type": "recommended", "evidence": [ { "id": "E1BHU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU7" } ] }, { "name": "OTOL1", "type": "synonym", "evidence": [ { "id": "NP_001179533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179533" } ] } ], "protein_names": [ { "name": "Otolin 1", "type": "synonym", "evidence": [ { "id": "E1BHU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU7/entry#names_and_taxonomy" } ] }, { "name": "otolin 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001179533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179533" } ] }, { "name": "otolin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179533" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHU7", "url": "https://www.uniprot.org/uniprotkb/E1BHU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OTOL1", "url": "https://www.uniprot.org/uniprotkb/E1BHU7", "locus": { "chromosome": "1", "start_pos": 105877308, "end_pos": 105908063, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018489", "url": "https://www.ensembl.org/id/ENSBTAG00000018489" } ] } } ], "crossref": [ { "id": "E1BHU7", "url": "https://alphafold.ebi.ac.uk/entry/E1BHU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018489", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525044", "url": "https://www.ncbi.nlm.nih.gov/gene/525044", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525044", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525044", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGYCGES", "url": "https://omabrowser.org/oma/group/KGYCGES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHU7", "url": "https://www.orthodb.org/?gene=E1BHU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHU7", "url": "https://www.uniprot.org/uniprotkb/E1BHU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHU7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWMFSWFCAIFIILVIASMDAVAKTTPYTKFTKKSEGKEMPKGPKPSSGLPPEEGAPFRDAAERAEPTPDPLVLDSAFDAATLFPSENLTLDTADFFLNCCDCCSSGPGQKGEPGQTGKPGFKGEAGNIGIPGSPGIVGPQGPKGQKGEKGFKGERGDQGASGVPGYPGKPGEPGGIGPKGDTGNIGPTGVKGQKGSKGDTCANGTKGDKGDRGPVGAPGLNGEPGAKGEKGEVGDKGYSGDSGERGEKGEKGEEGMKGEKGSKGDNGMEGKSGSDGLPGVPGDPGVKGEKGELGIPGLMGPVGPKGELGSKGVRGSIGKKGSRGLKGSKGEQARVPRSAFSAALSKPFPPPNAPIKFDKVLYNDQGNYSPVTGKFNCSIPGAYVFSYHITVRGRPARISLVAWNRKQFKSRETLYGHEIDQTSLLVILKLRAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPDENPSISP", "length": 473, "header": "tr|E1BHU7-1|E1BHU7_BOVIN Isoform 1 of Otolin 1 OS=Bos taurus OX=9913 GN=OTOL1 PE=4 SV=3 CANONICAL=E1BHU7-1" }, "isoforms": [ { "isoform_ac": "E1BHU7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU7/entry#E1BHU7-1", "sequence": { "sequence": "MWMFSWFCAIFIILVIASMDAVAKTTPYTKFTKKSEGKEMPKGPKPSSGLPPEEGAPFRDAAERAEPTPDPLVLDSAFDAATLFPSENLTLDTADFFLNCCDCCSSGPGQKGEPGQTGKPGFKGEAGNIGIPGSPGIVGPQGPKGQKGEKGFKGERGDQGASGVPGYPGKPGEPGGIGPKGDTGNIGPTGVKGQKGSKGDTCANGTKGDKGDRGPVGAPGLNGEPGAKGEKGEVGDKGYSGDSGERGEKGEKGEEGMKGEKGSKGDNGMEGKSGSDGLPGVPGDPGVKGEKGELGIPGLMGPVGPKGELGSKGVRGSIGKKGSRGLKGSKGEQARVPRSAFSAALSKPFPPPNAPIKFDKVLYNDQGNYSPVTGKFNCSIPGAYVFSYHITVRGRPARISLVAWNRKQFKSRETLYGHEIDQTSLLVILKLRAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPDENPSISP", "length": 473, "header": "tr|E1BHU7-1|E1BHU7_BOVIN Isoform 1 of Otolin 1 OS=Bos taurus OX=9913 GN=OTOL1 PE=4 SV=3 CANONICAL=E1BHU7-1" }, "locus": { "chromosome": "1", "start_pos": 105888889, "end_pos": 105877408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024606.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024606.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024606.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024606.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 189, "start_aa": "Thr", "end_pos": 189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 68, "start_aa": "Thr", "end_pos": 68, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr68", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:525044", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525044", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IQL5-1", "protein_name": "Otolin-1", "gene_name": "Otol1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWIFSWLCVLLIVLAVTDVDAVAKTTPYSKFTKKPDGKEMLKGLKPPNGFSLDDEETLLTEMAAMAEPTTGPSPSATAEPTTDPSASATASLFPFESFSLDTAGFFLNCCHCCSLVPGQKGNPGKMGEQGPKGETGDIGSPGPPGITGPQGPKGQKGEKGLKGERGDQGAGGVPGYPGKPGEQGGLGPKGDKGNIGPAGTKGQKGSKGDLCGNGTKGEKGDPGASGAHGFIGEPGVKGEKGVVGEKGNRGDPGERGEKGEKGEAGMEGEKGSRGDAGAEGKGGLDGLPGPRGDPGPKGEKGDTGPPGFTGPGGPKGELGSKGARGPTGKKGSRGVKGSKGEATQVPQSAFSALLSKPFPAPNIPIKFDKILSNDQGDYSPITGKFNCSAPGTYVFSYHVTVRGRPARISLVARNKKQFKSRETLYGQQVDQASLLLILKLSAGDQVWLEVSKDWNGLYVGPEDDSIFSGFLLYPEETLRKSP", "length": 482 }, "evidence": [ { "id": "E1BHU7", "url": "https://omabrowser.org/oma/group/E1BHU7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A5PN28-1", "protein_name": "Otolin-1-A", "gene_name": "otol1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPNILHPFIIIMTLLVVATGNQASIDKTTQWPRMKPTKKPPPRDEGPSKLGSISTTVSPTAIGITEEVTDAMMDAYTITSTGSTTFSSDTYSADYHTEAMVPPGVGPGNYTLDYNECFFNFCECCPPERGPPGPVGEKGLPGIPGGKGEMGPPGPPGQEGLTGAPGTHGVKGEKGDTGASGLPGIPGVTGKQGEKGESGPKGDKGDTGFPGLKGDPGERGEPGWNGTKGGMGEPGKQGLTGPPGPDGIKGEKGDKGDCPFGEKGQKGSIGEPGPQGPKGDPGVPGTNGTDGLPGSKGPKGDPGPLSKQGEPGPPGPQGPPGQRGMPGMKGTRGLKGARGIRGFKGFKGEPAVQKRSAFSVGLFPSRSFPPPGLPIRFDKIIYNEEAHWDPNASKFNCTHGGVYVFSYYITVRNRPLRAALVVNGIRKLRTRDSLYGQDIDQASNMAVLRLSSGDQVWLETLRDWNGVYSSSEDDSTFSGFLLYADATKD", "length": 489 }, "evidence": [ { "id": "E1BHU7", "url": "https://omabrowser.org/oma/group/E1BHU7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6NHN0-1", "protein_name": "Otolin-1", "gene_name": "OTOL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWMFSWLCAILIILAIAGMNTIAKTTPHTKFTKKSEEREMPKGLKPSSGPPPEEEETLFTEMAEMAEPITKPSALDSVFGTATLSPFENFTLDPADFFLNCCDCCSPVPGQKGEPGETGQPGPKGEAGNLGIPGPPGVVGPQGPRGYKGEKGLKGERGDQGVPGYPGKPGAQGEPGPKGDKGNIGLGGVKGQKGSKGDTCGNCTKGEKGDQGAMGSPGLHGGPGAKGEKGEMGEKGEMGDKGCCGDSGERGGKGQKGEGGMKGEKGSKGDSGMEGKSGRNGLPGAKGDPGIKGEKGELGPPGLLGPTGPKGDIGNKGVRGPTGKKGSRGFKGSKGELARVPRSAFSAGLSKPFPPPNIPIKFEKILYNDQGNYSPVTGKFNCSIPGTYVFSYHITVRGRPARISLVAQNKKQFKSRETLYGQEIDQASLLVILKLSAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPEETSGISP", "length": 477 }, "evidence": [ { "id": "E1BHU7", "url": "https://omabrowser.org/oma/group/E1BHU7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4ZJM7-1", "protein_name": "Otolin-1", "gene_name": "Otol1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWIFSSLCAVLTILAMDDVATEAKTTPYTKFTKKSEGKEMLKGLKPSSGFFLDGEETVHTETAAMAEPTTGSPALAMAESTAGPSASATTRLLPFESFSLDTTGFVLNCCHCCSFVTGQKGEPGKMGKQGPKGETGDTGSPGHPGTTGPQGPKGQKGEKGLKGDRGDQGAGGIPGYPGKPGEQGALGPKGDKGTIGPAGTKGQKGSKGELCGNGTKGEKGDPGASGAHGFIGEPGAKGEKGGVGEKGYRGDLGERGEKGQKGEKGMEGEKGSRGDVGSEGKRGSDGLPGLRGDSGPKGEKGEIGSPGFTGPAGPKGELGSKGVRGPTGKKGSRGVKGSKGEATQVPQSAFSALLSKPFPPPNVPIKFDKILSNDQGDYSPVTGKFNCSVPGTYIFSYHVTVRGRPARISLVARNRKQFKSRETLYGQQVDQASLLLILKLSAGDQVWLEVSKDWNGLYVGPEDDSIFSGFLLYPEETFSKSP", "length": 482 }, "evidence": [ { "id": "E1BHU7", "url": "https://omabrowser.org/oma/group/E1BHU7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BHU7", "url": "https://www.uniprot.org/uniprotkb/E1BHU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "E1BHU7", "url": "https://www.uniprot.org/uniprotkb/E1BHU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHU7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 473, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHU7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHU7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU7" }, { "id": "PS50871", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50871" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000259", "start_pos": 334, "end_pos": 469, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 68, 189 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHU8-1", "uniprot_ac": "E1BHU8", "uniprot_id": "E1BHU8_BOVIN", "mass": { "chemical_mass": 35242.0, "monoisotopic_mass": 35242.0 }, "refseq": { "ac": "NP_001376676", "name": "olfactory receptor 2D2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376676" }, "gene_names": [ { "name": "OR2D2", "type": "recommended", "evidence": [ { "id": "E1BHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ] }, { "name": "OR2D2", "type": "synonym", "evidence": [ { "id": "NP_001376676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376676" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 2 subfamily D member 2", "type": "synonym", "evidence": [ { "id": "E1BHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2D2", "type": "synonym", "evidence": [ { "id": "NP_001376676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376676" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376676" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2D2", "url": "https://www.uniprot.org/uniprotkb/E1BHU8", "locus": { "chromosome": "15", "start_pos": 45808159, "end_pos": 45807212, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018490", "url": "https://www.ensembl.org/id/ENSBTAG00000018490" } ] } } ], "crossref": [ { "id": "E1BHU8", "url": "https://alphafold.ebi.ac.uk/entry/E1BHU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504498", "url": "https://www.ncbi.nlm.nih.gov/gene/504498", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504498", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504498", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQIWVTE", "url": "https://omabrowser.org/oma/group/NQIWVTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHU8", "url": "https://www.orthodb.org/?gene=E1BHU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376676", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHU8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQTNQTQVTEFLLLGLSDDQHTQKLLFTLFLGVYLVTVLGNLLLMFLIQVDSQLHTPMYFFLCNLSLADLCFSTNIVPQALVHLLSRKKVISFTRCAAQLLLFLIFGCTQCALLAVMSCDRYVAICNPLHYPSTMTWRVCIQLAVGSWTSGILVSAVDTTFTLRLPYQGSNNVAHFFCEAPSILILASTDTHTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVRMRSAEGKLKAFSTCGSHLVVVILFYGSGIITYMTPKSYKEQKKLVSVFYAMVTPMLNPLIYSLRNKDVKGALRKVVIRNFPCRFGVFH", "length": 315, "header": "tr|E1BHU8-1|E1BHU8_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily D member 2 OS=Bos taurus OX=9913 GN=OR2D2 PE=3 SV=3 CANONICAL=E1BHU8-1" }, "isoforms": [ { "isoform_ac": "E1BHU8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU8/entry#E1BHU8-1", "sequence": { "sequence": "MRQTNQTQVTEFLLLGLSDDQHTQKLLFTLFLGVYLVTVLGNLLLMFLIQVDSQLHTPMYFFLCNLSLADLCFSTNIVPQALVHLLSRKKVISFTRCAAQLLLFLIFGCTQCALLAVMSCDRYVAICNPLHYPSTMTWRVCIQLAVGSWTSGILVSAVDTTFTLRLPYQGSNNVAHFFCEAPSILILASTDTHTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVRMRSAEGKLKAFSTCGSHLVVVILFYGSGIITYMTPKSYKEQKKLVSVFYAMVTPMLNPLIYSLRNKDVKGALRKVVIRNFPCRFGVFH", "length": 315, "header": "tr|E1BHU8-1|E1BHU8_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily D member 2 OS=Bos taurus OX=9913 GN=OR2D2 PE=3 SV=3 CANONICAL=E1BHU8-1" }, "locus": { "chromosome": "15", "start_pos": 45808156, "end_pos": 45807212, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024605.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024605.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024605.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024605.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504498", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504498", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A0B9-1", "protein_name": "Olfactory receptor family 2 subfamily D member 2B", "gene_name": "Or2d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRQANQTQVTEFLLLGLSDDPHTQTLLFILFLGIYLVTVLGNLLLMFLVRADSRLHTPMYFFLCNLSFADLCFSTNIVPQALTHFLSRKKSISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSIMTWRLCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIPHFFCEAPALLTLASIDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVAVFRMKSAAGRFKAFSTCGSHLIVVILFYGSAIITYMTPKSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKVALKNFSSRPIITQ", "length": 315 }, "evidence": [ { "id": "E1BHU8", "url": "https://omabrowser.org/oma/group/E1BHU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VG49-1", "protein_name": "Olfactory receptor family 2 subfamily D member 2", "gene_name": "Or2d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMQANQTQVTEFILLGLSDDPHTQKLLFILFLGIYMVTVLGNLLLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSIMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSAIITYMTPKSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKVAMKNFSSRLRITH", "length": 315 }, "evidence": [ { "id": "E1BHU8", "url": "https://omabrowser.org/oma/group/E1BHU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H210-1", "protein_name": "Olfactory receptor 2D2", "gene_name": "OR2D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRQINQTQVTEFLLLGLSDGPHTEQLLFIVLLGVYLVTVLGNLLLISLVHVDSQLHTPMYFFLCNLSLADLCFSTNIVPQALVHLLSRKKVIAFTLCAARLLFFLIFGCTQCALLAVMSYDRYVAICNPLRYPNIMTWKVCVQLATGSWTSGILVSVVDTTFILRLPYRGSNSIAHFFCEAPALLILASTDTHASEMAIFLMGVVILLIPVFLILVSYGRIIVTVVKMKSTVGSLKAFSTCGSHLMVVILFYGSAIITYMTPKSSKQQEKSVSVFYAIVTPMLNPLIYSLRNKDVKAALRKVATRNFP", "length": 308 }, "evidence": [ { "id": "E1BHU8", "url": "https://omabrowser.org/oma/group/E1BHU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BHU8", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHU8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 315, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHU8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHU8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHU8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHV9-1", "uniprot_ac": "E1BHV9", "uniprot_id": "E1BHV9_BOVIN", "mass": { "chemical_mass": 27527.0, "monoisotopic_mass": 27527.0 }, "refseq": { "ac": "NP_001166179", "name": "ornithine decarboxylase antizyme 3", "summary": "The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166179" }, "gene_names": [ { "name": "OAZ3", "type": "recommended", "evidence": [ { "id": "E1BHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ] }, { "name": "OAZ3", "type": "synonym", "evidence": [ { "id": "NP_001166179", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166179" } ] } ], "protein_names": [ { "name": "Ornithine decarboxylase antizyme 3", "type": "recommended", "evidence": [ { "id": "E1BHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHV9/entry#names_and_taxonomy" } ] }, { "name": "ornithine decarboxylase antizyme 3", "type": "synonym", "evidence": [ { "id": "NP_001166179", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166179" } ] } ], "function": [ { "annotation": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9#function" }, { "database": "UniProtKB", "id": "ARBA00053466", "url": "https://www.uniprot.org/uniprotkb/ARBA00053466#function" } ] }, { "annotation": "The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001166179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166179" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OAZ3", "url": "https://www.uniprot.org/uniprotkb/E1BHV9", "locus": { "chromosome": "3", "start_pos": 19015533, "end_pos": 19018603, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021591", "url": "https://www.ensembl.org/id/ENSBTAG00000021591" } ] } } ], "crossref": [ { "id": "E1BHV9", "url": "https://alphafold.ebi.ac.uk/entry/E1BHV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021591", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021591", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531865", "url": "https://www.ncbi.nlm.nih.gov/gene/531865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038581", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038581", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531865", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531865", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10279", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10279:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001166179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166179", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCYRSRPSFYSLSYIKRGKTRNYLYPFWSPYAYYLYCYKYRITLREKMLPCCKSITTYKEEEDLTLRPRCCLQCSESLVGLQGARHTEQGDQDQLKELYSAGNLTVLSTDPLLHKDPVQLDFHFRLTPQTSAHWHGLLCDHRLFLDIPYRALDQGNWESLTAALQYVEEKTNVDSVFVNIQNNRNDRGALLRAFSYMGFEVVRPDHPALPPWDNVIFMVYPLERDVGHLPSEPP", "length": 235, "header": "tr|E1BHV9-1|E1BHV9_BOVIN Isoform 1 of Ornithine decarboxylase antizyme 3 OS=Bos taurus OX=9913 GN=OAZ3 PE=3 SV=5 CANONICAL=E1BHV9-1" }, "isoforms": [ { "isoform_ac": "E1BHV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHV9/entry#E1BHV9-1", "sequence": { "sequence": "MPCYRSRPSFYSLSYIKRGKTRNYLYPFWSPYAYYLYCYKYRITLREKMLPCCKSITTYKEEEDLTLRPRCCLQCSESLVGLQGARHTEQGDQDQLKELYSAGNLTVLSTDPLLHKDPVQLDFHFRLTPQTSAHWHGLLCDHRLFLDIPYRALDQGNWESLTAALQYVEEKTNVDSVFVNIQNNRNDRGALLRAFSYMGFEVVRPDHPALPPWDNVIFMVYPLERDVGHLPSEPP", "length": 235, "header": "tr|E1BHV9-1|E1BHV9_BOVIN Isoform 1 of Ornithine decarboxylase antizyme 3 OS=Bos taurus OX=9913 GN=OAZ3 PE=3 SV=5 CANONICAL=E1BHV9-1" }, "locus": { "chromosome": "3", "start_pos": 19018571, "end_pos": 19015648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046490.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046490.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043786.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043786.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531865", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531865", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of polyamine transmembrane transport", "id": "GO:1902268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902268", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" }, { "name": "positive regulation of intracellular protein transport", "id": "GO:0090316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" }, { "name": "viral translational frameshifting", "id": "GO:0075523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075523", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ornithine decarboxylase inhibitor activity", "id": "GO:0008073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008073", "evidence": [ { "database": "UniProtKB", "id": "E1BHV9", "url": "https://www.uniprot.org/uniprotkb/E1BHV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHW7-1", "uniprot_ac": "E1BHW7", "uniprot_id": "E1BHW7_BOVIN", "mass": { "chemical_mass": 74871.0, "monoisotopic_mass": 74871.0 }, "refseq": { "ac": "NP_001192399", "name": "regulator of MON1-CCZ1 complex", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" }, "gene_names": [ { "name": "RMC1", "type": "recommended", "evidence": [ { "id": "E1BHW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" } ] }, { "name": "C24H18orf8", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] }, { "name": "RMC1", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] }, { "name": "WDR98", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] } ], "protein_names": [ { "name": "Regulator of MON1-CCZ1", "type": "synonym", "evidence": [ { "id": "E1BHW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW7/entry#names_and_taxonomy" } ] }, { "name": "Uncharacterized protein C18orf8 (Colon cancer-associated protein Mic1) (Mic-1)-like protein", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] }, { "name": "WD repeat domain 98", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] }, { "name": "regulator of MON1-CCZ1 complex", "type": "synonym", "evidence": [ { "id": "NP_001192399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHW7", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RMC1", "url": "https://www.uniprot.org/uniprotkb/E1BHW7", "locus": { "chromosome": "24", "start_pos": 33105334, "end_pos": 33127532, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015190", "url": "https://www.ensembl.org/id/ENSBTAG00000015190" } ] } } ], "crossref": [ { "id": "E1BHW7", "url": "https://alphafold.ebi.ac.uk/entry/E1BHW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015190", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015190", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100140797", "url": "https://www.ncbi.nlm.nih.gov/gene/100140797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VWVHNRE", "url": "https://omabrowser.org/oma/group/VWVHNRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHW7", "url": "https://www.orthodb.org/?gene=E1BHW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12897", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12897", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12897:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12897:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192399", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHW7", "url": "https://www.uniprot.org/uniprotkb/E1BHW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEEDYYLELCERPVHFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMEDKGEVKCIKFSLENKILAVQRTSKTVDFSNFIPDSSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVLPEKRNLKLLKSQNINVNWYMYCPEGSVILLSTTVLGNVLQPFYFRAGTMSKLPKFEIELPAAPKSTKLSLSERDIAMATIYGQLYVLFLRHHSRTSNSAGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIRLRGEFDGSVTLHHPVLPARSIQPYQIPAAGPAPVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRKECKMVILSVCSQMLTESDRATLPVIATVFDKLNQEYKKYLDAEQNYTMAVEAGQSRSGPLLRRPVRTQAVVDQSDMYTHVLSVFTEKKETPHKFVIAVLMEYIRSLNQFQITVQHYLHELVIRTLVQHSLFSTLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDHMLFYTIFRFFEQRNQRLRGNPSFTPGEHCEEHVAFFKQVFGDQALMRPTTF", "length": 657, "header": "tr|E1BHW7-1|E1BHW7_BOVIN Isoform 1 of Regulator of MON1-CCZ1 OS=Bos taurus OX=9913 GN=RMC1 PE=4 SV=2 CANONICAL=E1BHW7-1" }, "isoforms": [ { "isoform_ac": "E1BHW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW7/entry#E1BHW7-1", "sequence": { "sequence": "MGEEDYYLELCERPVHFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMEDKGEVKCIKFSLENKILAVQRTSKTVDFSNFIPDSSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVLPEKRNLKLLKSQNINVNWYMYCPEGSVILLSTTVLGNVLQPFYFRAGTMSKLPKFEIELPAAPKSTKLSLSERDIAMATIYGQLYVLFLRHHSRTSNSAGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIRLRGEFDGSVTLHHPVLPARSIQPYQIPAAGPAPVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRKECKMVILSVCSQMLTESDRATLPVIATVFDKLNQEYKKYLDAEQNYTMAVEAGQSRSGPLLRRPVRTQAVVDQSDMYTHVLSVFTEKKETPHKFVIAVLMEYIRSLNQFQITVQHYLHELVIRTLVQHSLFSTLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDHMLFYTIFRFFEQRNQRLRGNPSFTPGEHCEEHVAFFKQVFGDQALMRPTTF", "length": 657, "header": "tr|E1BHW7-1|E1BHW7_BOVIN Isoform 1 of Regulator of MON1-CCZ1 OS=Bos taurus OX=9913 GN=RMC1 PE=4 SV=2 CANONICAL=E1BHW7-1" }, "locus": { "chromosome": "24", "start_pos": 33127390, "end_pos": 33105510, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020214.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020214.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020214.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020214.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A4H7-1", "protein_name": "Regulator of MON1-CCZ1", "gene_name": "RMC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEENYYLELCERPVHFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMEDKGEVKCIKFSLENKILAVQRTSKTVDFSNFIPDSSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVLPEKRSLKLLKSQNINVNWYMYCPESAVILLSTTVLGNVLQPFYFRAGTMSKLPKFEIELPAAPKSTKLNLSERDIAMATIYGQLYVLFLRHHSRTSNSTGAEVVLYHLPREGACKKLHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIKLRGEFDGTVTLHHPVLPARSIQPYQIPAAGPAPVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRRDCKMVILSVCAQMLTESDRATLPVIATVFDKLNQEYKKYLDAEQSYTMAMEAGQSRSSPLLRRPVRTQAVVDQSDMYTHVLSAFTEKKETPHKFVVAVLMEYIRSLNQFQITVQHYLHELVIKTLVQHNLFYTLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDHMLFYTIFRFFEQRNQRLRGNPGFTPGEHCEEHVAFFKQVFGDQALMRPATF", "length": 657 }, "evidence": [ { "id": "E1BHW7", "url": "https://omabrowser.org/oma/group/E1BHW7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4J8L1-1", "protein_name": "C18orf8", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNSSAQAGVGSGALSHVYIHHPSLRCNIPESNGLFYDDANRLLICTTSSQVFSWETSPFNPDVPPSVDSISEGPILSIRFSLDKKAIAVQRSDCEIQLFNRETKQILNHKCKAGSESILGFFWSDSPLCDLAIVKTSGMDLFACDSMLNSLRLVETKKANVNWYIYTHETRLVLLASGLQCKTFNGFQLSTAGVVRLPRFEMTMARSESNSKPILSAGDLHLVTVYGRIYCLQVDREAMLLHLYRFYRDAVVQQGSLPIYSSKLSVNVVDNLLLVHQIDAKVVIIYDLFVDSRAPVSAPLPLLWRGYQVSETSSQAVNKEIESSESSTSNENIVMYEDGWTFLVPDLILDQTNKVLWKIHLDLEAISASSSDRTSLLEFLQRRKLEANKAKQLCLGIARAIILERRPATQVTQAIDVLVTAYSYSVKAGTYKEIKNENATASTPTPGASPDSERHRQSGSNIDEEVEMNLSSGSQENMFCADEQQESQLSSPAISPDELYKFVFTSVEEMMVEESEYLVAIITEFLRSISAEKLKVDLNIYVMTIKLLAYSKRFAELSLFTTNKIIEPSKEVAFQLLDSGRQNIRVRKLGLDMLRQLSLHHDYISSLVQDGYYLEALRYAQKHKVTSVRSSMFLEAAFASNDMQHLAAILRVLSELIPGFKETSEYYTFYGLLNDTSSSVAV", "length": 682 }, "evidence": [ { "id": "E1BHW7", "url": "https://omabrowser.org/oma/group/E1BHW7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8VC42-1", "protein_name": "Regulator of MON1-CCZ1 complex", "gene_name": "Rmc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGEDYYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMDDRGEVKCIKFSLENKILAVQRTAKAVDFCNFIPDNSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVMPEKRSLKLLKSHNINVNWYTYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEIELPAAPKSTKLSLSERDIAMATIYGQLYILFLRHHSRTSNSTGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIRLRGEFDGTVTFHHPVLPARSIQPYEIPLAGPAAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRKECKAVVLSVCSQMLSESDRATLPVIATVFDKLNHEYKKYLDADQSYTMAVEAGQSRSNPPLKRPVRTQAVVDQSDVYTQVLSPFVENKEMPHKFVIAVLMEYIRSLNQFQIPVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAARQTDDVMLFYTIFRFFEQRNQRLRGNPNFTPGEHCEEHVAFFKQVFGEQALMRPTTF", "length": 657 }, "evidence": [ { "id": "E1BHW7", "url": "https://omabrowser.org/oma/group/E1BHW7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DM3-1", "protein_name": "Regulator of MON1-CCZ1 complex", "gene_name": "RMC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEEDYYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMDDKGEVKCIKFSLENKILAVQRTSKTVDFCNFIPDNSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVLPEKRSLKLLKSHNLNVNWYMYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEIELPAAPKSTKPSLSERDIAMATIYGQLYVLFLRHHSRTSNSTGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIKLRGEFDGSVTFHHPVLPARSIQPYQIPITGPAAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLEPIVNLLPDKGRLMDFLLQRKECKMVILSVCSQMLSESDRASLPVIATVFDKLNHEYKKYLDAEQSYAMAVEAGQSRSSPLLKRPVRTQAVLDQSDVYTHVLSAFVEKKEMPHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPGEHCEEHVAFFKQIFGDQALMRPTTF", "length": 657 }, "evidence": [ { "id": "E1BHW7", "url": "https://omabrowser.org/oma/group/E1BHW7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VRX1-1", "protein_name": "Regulator of MON1-CCZ1 complex", "gene_name": "Bulli", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDNSNGIHYIELTPNPIRFDAVSQLTNVFFDDSNKQIFAVRSGGATGVVVKGPGSPDDVVISFCMSDRGGAIRSIKFSPDNQILAVQRKENSVEFICFQGDQPLLQDIITHQVKTLIHGFVWVHNREVALISNTGVEVYTVVPEKRQVRSVKSLSIGIKWFAWCCDANVALLCTSEGNSLIPVLVKQKVITKLPKVDLGNPSRDVQESKVTLGQVYGVLAVLILQSNSTTGLMEVEVHLLNGPGLAPRKCHVLRLSLLGRFAINTVDNLIVVHHQASGTSLLFDISLPGEVINEITYHTPITPGRSIKPFGLKLPSLSPDGQILQCELYSTHWVLFQPNIVIDAKLGCMWFLNLCIEPLCQLISDRIRLTEFLLQRSNGKQMLLKVIGQLVDDQYKGTLLPVLETIFSRINKIYASWVQLELQNQTAQPSNVKTTTLKQSTPPIVLIEQLDMVQIFQRIARRPYTESILMLYLQSLNKFNIAAQEELSKMIISELISNRSFDTLRRLVSYSMLLESKSVACFLLSHSNVDTAISQVAIDMLGRIEAHEIIIEVMLGQGKVIDALRLAKNSMGLEKVPARKFLEAAHKTKDDLIFHSVYRFFQMRNLKLYETLSFPKAEQCTEFIQHYNNTFPADNPTRQPVS", "length": 642 }, "evidence": [ { "id": "E1BHW7", "url": "https://omabrowser.org/oma/group/E1BHW7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "E1BHW7", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "E1BHW7", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" } ], "pmid": "" }, { "name": "Mon1-Ccz1 complex", "id": "GO:0035658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035658", "evidence": [ { "database": "UniProtKB", "id": "E1BHW7", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHW7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 657, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHW7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHW7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" }, { "id": "PF07035", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mic1", "eco_id": "ECO_0000259", "start_pos": 383, "end_pos": 631, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW7" }, { "id": "PF21029", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21029" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Regulator of MON1-CCZ1 complex N-terminal", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 144, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 429, "end_pos": 431 }, { "start_pos": 590, "end_pos": 592 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHW8-1", "uniprot_ac": "E1BHW8", "uniprot_id": "E1BHW8_BOVIN", "mass": { "chemical_mass": 53409.0, "monoisotopic_mass": 53409.0 }, "refseq": { "ac": "XP_005203203", "name": "UBX domain-containing protein 11 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203203" }, "gene_names": [ { "name": "UBXN11", "type": "recommended", "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" } ] }, { "name": "UBXN11", "type": "synonym", "evidence": [ { "id": "XP_005203203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203203" } ] } ], "protein_names": [ { "name": "UBX domain-containing protein 11", "type": "recommended", "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#names_and_taxonomy" } ] }, { "name": "Socius", "type": "synonym", "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#names_and_taxonomy" } ] }, { "name": "UBX domain-containing protein 11 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203203" } ] }, { "name": "UBX domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.", "evidence": [ { "database": "UniProtKB", "id": "E1BHW8", "url": "https://www.uniprot.org/uniprotkb/E1BHW8#function" }, { "database": "UniProtKB", "id": "ARBA00059434", "url": "https://www.uniprot.org/uniprotkb/ARBA00059434#function" }, { "database": "UniProtKB", "id": "A0A3Q1M5S4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S4#function" }, { "database": "UniProtKB", "id": "A0AAA9TNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHW8", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBXN11", "url": "https://www.uniprot.org/uniprotkb/E1BHW8", "locus": { "chromosome": "2", "start_pos": 126836843, "end_pos": 126814773, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009581", "url": "https://www.ensembl.org/id/ENSBTAG00000009581" } ] } } ], "crossref": [ { "id": "E1BHW8", "url": "https://alphafold.ebi.ac.uk/entry/E1BHW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009581", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009581", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515112", "url": "https://www.ncbi.nlm.nih.gov/gene/515112", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DFELMSA", "url": "https://omabrowser.org/oma/group/DFELMSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHW8", "url": "https://www.orthodb.org/?gene=E1BHW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23333:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23333:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203203", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203203", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5S4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5S4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHW8", "url": "https://www.uniprot.org/uniprotkb/E1BHW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHW8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPLASLGKTRRVPLQSEPVNPGRRGIKIYGNEDEVDMLNGAHGSEERISVPSCYGGIGAPVSRQVPVYNDSELVATLTRKLRDLERQVKAQTDEILSKTRKIQALEEMVETLEKHQGKVSLQRQEELETVCAKLQRQVGEMERFLGDYGLQWVGEPMDQEDSEDGERDWMTAKKFWKPGDSLVPPEVDFDRLLASLKDLSELVEDSDTQVMPVPDRVPHQTLEPIPLRLYRNGIVMFDGPFRPFHDPSTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRSQVYPEHGLDPFPGEGRVVGLQRIRKPLDSIEHSGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPVRIQEIVVETPALAAERVRSRESPESPAPLLSMLRIKSENGEQAFLLMMRPEDRVGDVRALLAQARAVEPSTFEIFSTFPPTVYNDDALTLQAAGLVPNATLLLRVRRASPPAPGPK", "length": 475, "header": "tr|E1BHW8-1|E1BHW8_BOVIN Isoform 1 of UBX domain-containing protein 11 OS=Bos taurus OX=9913 GN=UBXN11 PE=4 SV=3 CANONICAL=E1BHW8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5S4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#A0A3Q1M5S4-1", "sequence": { "sequence": "MSSPLASLGKTRRVPLQSEPVNPGRRGIKIYGNVPVYNDSELVATLTRKLRDLERQVKAQTDEILSKTRKIQALEEMVETLEKHQGKVSLQRQEELETVCAKLQRQVGEMERFLGDYGLQWVGEPMDQEDSEDGERDWMTAKKFWKPGDSLVPPEVDFDRLLASLKDLSELVEDSDTQVMPVPDRVPHQTLEPIPLRLYRNGIVMFDGPFRPFHDPSTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRSQVYPEHGLDPFPGEGRVVGLQRIRKPLDSIEHSGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPVRIQEIVVETPALAAERVRSRESPESPAPLLSMLRIKSENGEQAFLLMMRPEDRVGDVRALLAQARAVEPSTFEIFSTFPPTVYNDDALTLQAAGLVPNATLLLRVRRASPPAPGPK", "length": 442, "header": "tr|A0A3Q1M5S4-1|A0A3Q1M5S4_BOVIN Computationally mapped isoform of UBX domain-containing protein 11 OS=Bos taurus OX=9913 GN=UBXN11 PE=4 SV=1 CANONICAL=E1BHW8-1" }, "locus": { "chromosome": "2", "start_pos": 126836824, "end_pos": 126819390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077393.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077393.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063624.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063624.2" } ] } }, { "isoform_ac": "A0AAA9TNM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#A0AAA9TNM2-1", "sequence": { "sequence": "MSSPLASLGKTRRVPLQSEPVNPGRRGIKIYGNEDEVDMLNGAHGSEERISVPSCYGGIGAPVSRQGDSLVPPEVDFDRLLASLKDLSELVEDSDTQVMPVPDRVPHQTLEPIPLRLYRNGIVMFDGPFRPFHDPSTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRSQVYPEHGLDPFPGEGRVVGLQRIRKPLDSIEHSGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPVRIQEIVVETPALAAERVRSRESPESPAPLLSMLRIKSENGEQAFLLMMRPEDRVGDVRALLAQARAVEPSTFEIFSTFPPTVYNDDALTLQAAGLVPNATLLLRVRRASPPAPGPK", "length": 361, "header": "tr|A0AAA9TNM2-1|A0AAA9TNM2_BOVIN Computationally mapped isoform of UBX domain-containing protein 11 OS=Bos taurus OX=9913 GN=UBXN11 PE=4 SV=1 CANONICAL=E1BHW8-1" }, "locus": { "chromosome": "2", "start_pos": 126836824, "end_pos": 126819390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096816.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096816.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097953.1" } ] } }, { "isoform_ac": "E1BHW8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW8/entry#E1BHW8-1", "sequence": { "sequence": "MSSPLASLGKTRRVPLQSEPVNPGRRGIKIYGNEDEVDMLNGAHGSEERISVPSCYGGIGAPVSRQVPVYNDSELVATLTRKLRDLERQVKAQTDEILSKTRKIQALEEMVETLEKHQGKVSLQRQEELETVCAKLQRQVGEMERFLGDYGLQWVGEPMDQEDSEDGERDWMTAKKFWKPGDSLVPPEVDFDRLLASLKDLSELVEDSDTQVMPVPDRVPHQTLEPIPLRLYRNGIVMFDGPFRPFHDPSTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRSQVYPEHGLDPFPGEGRVVGLQRIRKPLDSIEHSGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPVRIQEIVVETPALAAERVRSRESPESPAPLLSMLRIKSENGEQAFLLMMRPEDRVGDVRALLAQARAVEPSTFEIFSTFPPTVYNDDALTLQAAGLVPNATLLLRVRRASPPAPGPK", "length": 475, "header": "tr|E1BHW8-1|E1BHW8_BOVIN Isoform 1 of UBX domain-containing protein 11 OS=Bos taurus OX=9913 GN=UBXN11 PE=4 SV=3 CANONICAL=E1BHW8-1" }, "locus": { "chromosome": "2", "start_pos": 126836824, "end_pos": 126819390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012602.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012602.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012602.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012602.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YLP9-1", "protein_name": "UBX domain-containing protein 11", "gene_name": "UBXN11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELMSSMMQKISLLEQKIDKQAQEIQLKDRKIAELEEKMKTLQKGEDAPDSSTAEDLETRCLQLQTQVWEMERFLNDYGLVWVGDRHEEQEDLESLRDDELLAKRKPGEAVVSKHQVDFDLILENVKSLNMLAGDCISHIEHTPGGARLRQPEPLPLTLYQNGIVMLDGPFRSYEELSVQQCLQDIMDGYFPSELQARYPDGVPLQVTDKRDVVFQERDLPGSFPGHGQVVGHSKLSKVEEPAKIPGPKPSLEQFWNKYSKSSMHSEAMATRDTVGAMQQGSDGVWSSKEIVVGTPRLSVLQRLETSEEAEASAPDVCTLRIKSESGEQMYVIKMLSSETIGDLRQHLAHARGGDSDSYEIISTFPQRVYADNSRSLQECGLIPNASLLLRRRDPFPPEGTALQTA", "length": 406 }, "evidence": [ { "id": "E1BHW8", "url": "https://omabrowser.org/oma/group/E1BHW8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1R1A5-1", "protein_name": "UBX domain-containing protein 11", "gene_name": "ubxn11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSPLSILRKNRRAPLPDLHTDGERKPHKERSDSDYEEKLFQDIFPQNQPVPRVPDHLSTLRSKFMQKKKAKAAVPSDFELMSSMMQKICHLERKVKTQAVDIEQKARRIAVLEEKLNILREAKVLEESASNENQDEGLVQFCLKLQKQVWEMENFLNDYGMIWVGGYEENQDERAESQLTGASSGRKRFEMNFDLVMQNVKELNLEAGEGESHVTAIPGGAKLTQKPPIPLWLYKNGIVMFNGPFRSYQDPTTQECMQDLMDGFFPSELQERFPNGVPFQVNDRREEEFIVRRPRAEFPGRGQTIDGGQQMMDSSEISSTIPKQSQIAGRKLSMEQFLRKLPETVVKAGKVISIRDSVKAHLLGLSDDAKSRSAIIVETSALQSSRECENDSSKSAKDVSTLRVKSEDGTDTFIIKMYFTETIGDLRQYLDVKRGPSAASYDIISAFPQRRYSDDTQTLLACGLTPNAALLLRAQAPAHRH", "length": 482 }, "evidence": [ { "id": "E1BHW8", "url": "https://omabrowser.org/oma/group/E1BHW8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5T124-1", "protein_name": "UBX domain-containing protein 11", "gene_name": "UBXN11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSPLASLSKTRKVPLPSEPMNPGRRGIRIYGDEDEVDMLSDGCGSEEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQKIAALEDLVQTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMDQEDSESKTVSEHGERDWMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQVTPVPGGARLRTLEPIPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILDGFFPSELQRLYPNGVPFKVSDLRNQVYLEDGLDPFPGEGRVVGRQLMHKALDRVEEHPGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPARIQEIVVETPTLAAERERSQESPNTPAPPLSMLRIKSENGEQAFLLMMQPDNTIGDVRALLAQARVMDASAFEIFSTFPPTLYQDDTLTLQAAGLVPKAALLLRARRAPKSSLKFSPGPCPGPGPGPSPGPGPGPSPGPGPGPSPCPGPSPSPQ", "length": 520 }, "evidence": [ { "id": "E1BHW8", "url": "https://omabrowser.org/oma/group/E1BHW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R512-1", "protein_name": "UBX domain-containing protein 11", "gene_name": "Ubxn11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSPLASLSKTRKVPLESEPVNPGRRGIRIYGDEDEVDMVNDGQDSEEKISLPSCYGGIGRQGLMIHDSELLTSMARKLQELEQQLKARNEEMLSKEQKILALEDLVQTLQQHQSSTTREEELETQCIQLQRQVGEMERFLNDYGLQWVGEPMDQENSEGKIISESDERDWMKAKKFWKPGDSIVPPEVDFDRLLSSLQDLSELVVEGEAQVTPVPGGAQFRTLEPIPLKLYRNGIMMFDGPFRPFYDPYTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRNQVYPEDGLGPFPGEGRVVGRQKIRKVTDRVEETSGSRMTAEKFLNRLPKCVIRQGEVIDIRGPIRDTLQNCCPMPVRIQEIIVETPALASERQRTQESPNMPVPPLSMLRIKSENGEQAFLLMMRPEDTIGDVRNLLAQARDMDSAAFEILSTFPPTVYRDDTVTLQAAGLVPNATLLLRTRRVLPANPSFGTDSGPGSLP", "length": 485 }, "evidence": [ { "id": "E1BHW8", "url": "https://omabrowser.org/oma/group/E1BHW8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D572-1", "protein_name": "UBX domain-containing protein 11", "gene_name": "Ubxn11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSPLASLSKTRKVPLESESVNPGRRGIRVYGNEDEVDMWNDGQDSEEKISLPSCYGGIGAPVSRQGPHDSELMASMTRKLQELEQQLQAQNDEMLSKERKILDLEDLVQTLQQHQNNAALQRQEELETQCIQLQRQIGEMERFLSDYGLQWVGEPMDQENSEEKTVSENDERDWMKAKKFWKPGDSFVPPEVDFDKLMASLQDLSELVEGEAQVTPVPGGARFRTLEPIPLKVYRNGIMMFDGPFRPFYDPSTQRCLRDILDGFFPSELQRLYPDGVPFKVSDLRNQIYPEDGLGQFPGEGRVVGRQKMRKVTDRVEETSGSRMTAEQFLNRLPKCIIRQGEVIDIRGPIRDTLQNCCPMPARIQEIIVETPALASERQRSQESPDMPMPLLSMLRIKSENGEQAFLLMMWPEDTIGDVRKLLAQARDMDSAAFEILSTFPPTVYQDDTVTLQAAGLVPNATLLLRTRRALLSNPISRPGSLP", "length": 484 }, "evidence": [ { "id": "E1BHW8", "url": "https://omabrowser.org/oma/group/E1BHW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BHW8", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHW8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 475, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHW8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHW8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" }, { "id": "PS51399", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51399" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEP", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 288, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" }, { "id": "PS50033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBX", "eco_id": "ECO_0000259", "start_pos": 385, "end_pos": 462, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BHW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW8" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 390, "end_pos": 469, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 457, "end_pos": 459 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BHW9-1", "uniprot_ac": "E1BHW9", "uniprot_id": "E1BHW9_BOVIN", "mass": { "chemical_mass": 51795.0, "monoisotopic_mass": 51795.0 }, "refseq": { "ac": "XP_002694170", "name": "MORN repeat-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694170" }, "gene_names": [ { "name": "MORN1", "type": "recommended", "evidence": [ { "id": "E1BHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW9" } ] }, { "name": "MORN1", "type": "synonym", "evidence": [ { "id": "XP_002694170", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694170" } ] } ], "protein_names": [ { "name": "MORN repeat containing 1", "type": "synonym", "evidence": [ { "id": "E1BHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHW9/entry#names_and_taxonomy" } ] }, { "name": "MORN repeat-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002694170", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694170" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BHW9", "url": "https://www.uniprot.org/uniprotkb/E1BHW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MORN1", "url": "https://www.uniprot.org/uniprotkb/E1BHW9", "locus": { "chromosome": "16", "start_pos": 50502221, "end_pos": 50453009, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009306", "url": "https://www.ensembl.org/id/ENSBTAG00000009306" } ] } } ], "crossref": [ { "id": "E1BHW9", "url": "https://alphafold.ebi.ac.uk/entry/E1BHW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009306", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009306", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617176", "url": "https://www.ncbi.nlm.nih.gov/gene/617176", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617176", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GEYVIMI", "url": "https://omabrowser.org/oma/group/GEYVIMI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHW9", "url": "https://www.orthodb.org/?gene=E1BHW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23084", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23084", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23084:SF263", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23084:SF263", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694170", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694170", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BHW9", "url": "https://www.uniprot.org/uniprotkb/E1BHW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLLRETSSGKMAFASEGRATSCLPHRELPGRPPRDGYGVYVYPNSFFRYEGEWRGGKKHGQGKLLFKDGSYYEGDFVDGEITGEGCRHWALTGNTYTGQFVLGEPQGHGIMKYQAGGHYEGELFRGLREGHGCLVDADGQVYWGSFHDNKRHGQGQMVFRNGDKYEGNWVRDQRQGHGMLRLADGSTYEGQWHSGVFSGQGSMAHCSGVIYRGIWINGHPMAQATRIAILGPEVMDTAQGSSLVLTVQLQQDNGEVATSEDGRELEISAGVRYVQLPAYSEVSFFRVDDGLGQTPIQTPFGFQCISYPLSSPASEGPEPRAALESASTDSLLPDGDPGGPPAGKHEPRCPGSRRRAERGCVQFSDVHLGPPPPGYHAILFLEGLHEVGSRPRGQDHRGMTPIAQGPPGGSRLDGVATVEPAAEAFPGEYVIMIRDVTTPPFLGHTLPTAFKHLRVLARGAGQQPHVPREDPEALS", "length": 476, "header": "tr|E1BHW9-1|E1BHW9_BOVIN Isoform 1 of MORN repeat containing 1 OS=Bos taurus OX=9913 GN=MORN1 PE=4 SV=3 CANONICAL=E1BHW9-1" }, "isoforms": [ { "isoform_ac": "E1BHW9-1", "url": "https://www.uniprot.org/uniprotkb/E1BHW9/entry#E1BHW9-1", "sequence": { "sequence": "MWLLRETSSGKMAFASEGRATSCLPHRELPGRPPRDGYGVYVYPNSFFRYEGEWRGGKKHGQGKLLFKDGSYYEGDFVDGEITGEGCRHWALTGNTYTGQFVLGEPQGHGIMKYQAGGHYEGELFRGLREGHGCLVDADGQVYWGSFHDNKRHGQGQMVFRNGDKYEGNWVRDQRQGHGMLRLADGSTYEGQWHSGVFSGQGSMAHCSGVIYRGIWINGHPMAQATRIAILGPEVMDTAQGSSLVLTVQLQQDNGEVATSEDGRELEISAGVRYVQLPAYSEVSFFRVDDGLGQTPIQTPFGFQCISYPLSSPASEGPEPRAALESASTDSLLPDGDPGGPPAGKHEPRCPGSRRRAERGCVQFSDVHLGPPPPGYHAILFLEGLHEVGSRPRGQDHRGMTPIAQGPPGGSRLDGVATVEPAAEAFPGEYVIMIRDVTTPPFLGHTLPTAFKHLRVLARGAGQQPHVPREDPEALS", "length": 476, "header": "tr|E1BHW9-1|E1BHW9_BOVIN Isoform 1 of MORN repeat containing 1 OS=Bos taurus OX=9913 GN=MORN1 PE=4 SV=3 CANONICAL=E1BHW9-1" }, "locus": { "chromosome": "16", "start_pos": 50502159, "end_pos": 50453167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012258.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012258.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012258.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012258.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617176", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5T089-1", "protein_name": "MORN repeat-containing protein 1", "gene_name": "MORN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAGEGTPSSRGPRRDPPRRPPRNGYGVYVYPNSFFRYEGEWKAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSGDTFSGQFVLGEPQGYGVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGDWVRDRRQGHGVLRCADGSTYKGQWHSDVFSGLGSMAHCSGVTYYGLWINGHPAEQATRIVILGPEVMEVAQGSPFSVNVQLLQDHGEIAKSESGRVLQISAGVRYVQLSAYSEVNFFKVDRDNQETLIQTPFGFECIPYPVSSPAAGVPGPRAAKGGAEADVPLPRGDLELHLGALHGQEDTPGGLLARGHAPHCPGACQRVEQGCAEFTDVLLGPPPPGYHPFLFLDSLHKKAGGRSRGGLHPRGTPPTAQEPPGGSRPEGRATEEQAAAAHLGEYVLMIRDVTTPPFLGRRLPPAFKHLRVVAKRAGQPPHVLEEGPEASSSWQAAHSCTPEPPAPR", "length": 497 }, "evidence": [ { "id": "E1BHW9", "url": "https://omabrowser.org/oma/group/E1BHW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q641X6-1", "protein_name": "MORN repeat-containing protein 1", "gene_name": "Morn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAEDQNPASLQPLRHSPRLRPRNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVNGEITGEGYQHWAWSGNTYSGQFVLGEPQGHGIMKYKAGGHYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMVFKNGDKYEGDWVRDQRQGHGVLFCADGSTYKGQWHNDVFSGLGSLVHCSGVTYCGMFINGHPAAQAKKIVVLGPELLEVVQGSPFTLSVQLQQDDGEVAKSESGRVLKISAGVRYVQLPEYSEVSFFKMDDAHMETPIQTPFGFQCIPYPLSVSTSWGLEPGSTVESARADLLLSKKDSEPVLDSEAFHGKGDTLSILPARRHEPCCSAAYQRVDQGCAEFVDIHLGAPPPGMQPYLFLPSMLEKAGNRPKGDRSPPEVLSTAQEPLRGTNRSDGTTAEPSTAAYLGEYVLMVCDVTSPPFLGHRLPTTFKHLRILARGDIHLPHVPEDHPEALS", "length": 483 }, "evidence": [ { "id": "E1BHW9", "url": "https://omabrowser.org/oma/group/E1BHW9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BHW9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 476, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BHW9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BHW9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI07-1", "uniprot_ac": "E1BI07", "uniprot_id": "E1BI07_BOVIN", "mass": { "chemical_mass": 26364.0, "monoisotopic_mass": 26364.0 }, "refseq": { "ac": "XP_005227987", "name": "LHFPL tetraspan subfamily member 1 protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227987" }, "gene_names": [ { "name": "LHFPL1", "type": "recommended", "evidence": [ { "id": "E1BI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI07" } ] }, { "name": "LHFPL1", "type": "synonym", "evidence": [ { "id": "XP_005227987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227987" } ] } ], "protein_names": [ { "name": "LHFPL tetraspan subfamily member 1 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227987" } ] }, { "name": "LHFPL tetraspan subfamily member 1", "type": "synonym", "evidence": [ { "id": "E1BI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI07/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI07", "url": "https://www.uniprot.org/uniprotkb/E1BI07" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LHFPL1", "url": "https://www.uniprot.org/uniprotkb/E1BI07", "locus": { "chromosome": "X", "start_pos": 61080779, "end_pos": 61150838, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032485", "url": "https://www.ensembl.org/id/ENSBTAG00000032485" } ] } } ], "crossref": [ { "id": "E1BI07", "url": "https://alphafold.ebi.ac.uk/entry/E1BI07", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032485", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032485", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781310", "url": "https://www.ncbi.nlm.nih.gov/gene/781310", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VMQTCGN", "url": "https://omabrowser.org/oma/group/VMQTCGN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI07", "url": "https://www.orthodb.org/?gene=E1BI07", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12489:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12489:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227987", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227987", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI07", "url": "https://www.uniprot.org/uniprotkb/E1BI07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI07-1", "url": "https://www.uniprot.org/uniprotkb/E1BI07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTFCIWRCEPTHLPIPTEKPGTMRSSLTLVGTLWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGEGQSLIMVEECGRYASFSAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVESIMRNTNSYTMELDHCLKP", "length": 243, "header": "tr|E1BI07-1|E1BI07_BOVIN Isoform 1 of LHFPL tetraspan subfamily member 1 OS=Bos taurus OX=9913 GN=LHFPL1 PE=4 SV=2 CANONICAL=E1BI07-1" }, "isoforms": [ { "isoform_ac": "E1BI07-1", "url": "https://www.uniprot.org/uniprotkb/E1BI07/entry#E1BI07-1", "sequence": { "sequence": "MTTFCIWRCEPTHLPIPTEKPGTMRSSLTLVGTLWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGEGQSLIMVEECGRYASFSAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVESIMRNTNSYTMELDHCLKP", "length": 243, "header": "tr|E1BI07-1|E1BI07_BOVIN Isoform 1 of LHFPL tetraspan subfamily member 1 OS=Bos taurus OX=9913 GN=LHFPL1 PE=4 SV=2 CANONICAL=E1BI07-1" }, "locus": { "chromosome": "X", "start_pos": 61141756, "end_pos": 61081002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046071.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046071.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043399.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043399.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MUG9-1", "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "Lhfpl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRSSLTLVGTFWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGDGHNLIMVEECGRYASFTAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEVMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVESIMRNTNSYAMELDHCLKP", "length": 220 }, "evidence": [ { "id": "E1BI07", "url": "https://omabrowser.org/oma/group/E1BI07/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RWT8-1", "protein_name": "LHFPL tetraspan subfamily member 1", "gene_name": "LHFPL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MITFCVWCCDPTHLPIPAEKPGTMRSSLTLLGTLWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGEGQSLIMVEECGRYASFSAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVESIMRNTNSYAMELDHCLKP", "length": 243 }, "evidence": [ { "id": "E1BI07", "url": "https://omabrowser.org/oma/group/E1BI07/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80SV1-1", "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "Lhfpl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNSLTMVGTFWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGDGHNLIMVEECGRYASFTAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISAGCALYPLGWNSPEVMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVENIMRNTNSYALELDHCLKP", "length": 220 }, "evidence": [ { "id": "E1BI07", "url": "https://omabrowser.org/oma/group/E1BI07/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80WE5-1", "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "Lhfpl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSSLTLVGTFWAFLSLVTAVASSTSYFLPYWLFGSQLGKPVSFSTFRRCNYPVRGDGHNLIMVEECGRYASFAAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEVMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVMLVENIMRNTNSYAMELDHCLKP", "length": 220 }, "evidence": [ { "id": "E1BI07", "url": "https://omabrowser.org/oma/group/E1BI07/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86WI0-1", "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "LHFPL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSSLTMVGTLWAFLSLVTAVTSSTSYFLPYWLFGSQMGKPVSFSTFRRCNYPVRGEGHSLIMVEECGRYASFNAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVILVESIMRNTNSYAMELDHCLKP", "length": 220 }, "evidence": [ { "id": "E1BI07", "url": "https://omabrowser.org/oma/group/E1BI07/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BI07", "url": "https://www.uniprot.org/uniprotkb/E1BI07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI07-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 243, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI07-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI07" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI09-1", "uniprot_ac": "E1BI09", "uniprot_id": "E1BI09_BOVIN", "mass": { "chemical_mass": 32723.0, "monoisotopic_mass": 32723.0 }, "refseq": { "ac": "NP_001138533", "name": "glycine N-acyltransferase-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138533" }, "gene_names": [ { "name": "GLYATL3", "type": "recommended", "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09" } ] }, { "name": "GLYATL3", "type": "synonym", "evidence": [ { "id": "NP_001138533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138533" } ] } ], "protein_names": [ { "name": "Glycine N-acyltransferase-like protein", "type": "recommended", "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.-", "type": "synonym", "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09/entry#names_and_taxonomy" } ] }, { "name": "glycine N-acyltransferase-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001138533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138533" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI09", "url": "https://www.uniprot.org/uniprotkb/E1BI09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLYATL3", "url": "https://www.uniprot.org/uniprotkb/E1BI09", "locus": { "chromosome": "23", "start_pos": 22308212, "end_pos": 22294633, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025535", "url": "https://www.ensembl.org/id/ENSBTAG00000025535" } ] } } ], "crossref": [ { "id": "E1BI09", "url": "https://alphafold.ebi.ac.uk/entry/E1BI09", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025535", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025535", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787783", "url": "https://www.ncbi.nlm.nih.gov/gene/787783", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787783", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787783", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BI09", "url": "https://www.orthodb.org/?gene=E1BI09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-177128", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177128", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-177135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9749641", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001138533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI09", "url": "https://www.uniprot.org/uniprotkb/E1BI09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI09-1", "url": "https://www.uniprot.org/uniprotkb/E1BI09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQVLNCSTKLLLLEKMLKSHFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAIITRRQKEAETDNLDHYTNAYAVFYKDVNAYRQLLEEHGVINWDQVFQIQGLQSELYDVSKAVADSKQVDVKLASFKAACLPPISTVDTSFLMNSSVQLTYLSIADVDLLNQTWSRGGNEQCRRYIANLISCFPSVCVRDDKGNPMSWSMTDQFATMCHGYTMPEHRRKGYNRLVILMLARKLQSRGFPCQGNILDDNTTSINLTKSIHSDFLPCRFHRLILTPPAFSGQVHP", "length": 287, "header": "tr|E1BI09-1|E1BI09_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=GLYATL3 PE=3 SV=4 CANONICAL=E1BI09-1" }, "isoforms": [ { "isoform_ac": "E1BI09-1", "url": "https://www.uniprot.org/uniprotkb/E1BI09/entry#E1BI09-1", "sequence": { "sequence": "MQVLNCSTKLLLLEKMLKSHFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAIITRRQKEAETDNLDHYTNAYAVFYKDVNAYRQLLEEHGVINWDQVFQIQGLQSELYDVSKAVADSKQVDVKLASFKAACLPPISTVDTSFLMNSSVQLTYLSIADVDLLNQTWSRGGNEQCRRYIANLISCFPSVCVRDDKGNPMSWSMTDQFATMCHGYTMPEHRRKGYNRLVILMLARKLQSRGFPCQGNILDDNTTSINLTKSIHSDFLPCRFHRLILTPPAFSGQVHP", "length": 287, "header": "tr|E1BI09-1|E1BI09_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=GLYATL3 PE=3 SV=4 CANONICAL=E1BI09-1" }, "locus": { "chromosome": "23", "start_pos": 22307208, "end_pos": 22294658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035917.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035917.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035783.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035783.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:787783", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787783", "resource": "KEGG Pathway" }, { "id": "R-BTA-159424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159424", "resource": "Reactome", "description": "Conjugation of carboxylic acids" }, { "id": "R-BTA-177128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177128", "resource": "Reactome", "description": "Conjugation of salicylate with glycine" }, { "id": "R-BTA-177135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177135", "resource": "Reactome", "description": "Conjugation of benzoate with glycine" }, { "id": "R-BTA-9749641", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9749641", "resource": "Reactome", "description": "Aspirin ADME" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BI09", "url": "https://www.uniprot.org/uniprotkb/E1BI09" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glycine N-acyltransferase activity", "id": "GO:0047961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047961", "evidence": [ { "database": "UniProtKB", "id": "E1BI09", "url": "https://www.uniprot.org/uniprotkb/E1BI09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-159564" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-159566", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159566" } ] }, { "id": "R-BTA-159574", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-159572" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-159574", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159574" } ] }, { "id": "R-BTA-9750001", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-9749985" ], "output_participant_list": [ "R-ALL-9750005" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9750001", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9750001" } ] }, { "id": "R-BTA-9971063", "name": "GLYAT-like proteins transfer glycine to phenylacetyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-177137" ], "output_participant_list": [ "R-ALL-9971077" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9971063", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9971063" } ] }, { "id": "R-BTA-9972916", "name": "GLYAT-like proteins transfer glycine to aminobenzoyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-9972915" ], "output_participant_list": [ "R-ALL-9972914" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9972916", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9972916" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-159564", "participant_name": "HIPA [mitochondrial matrix]", "crossref": [ { "id": "C01586", "database": "COMPOUND", "url": "" }, { "id": "606565", "database": "ChEBI", "url": "" }, { "id": "ZINC000006344064", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-159572", "participant_name": "SUA [mitochondrial matrix]", "crossref": [ { "id": "8145924", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000000125017", "database": "ZINC", "url": "" }, { "id": "9008", "database": "ChEBI", "url": "" }, { "id": "C07588", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000840", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-177137", "participant_name": "phenylacetyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "57390", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014556", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9749985", "participant_name": "2,5-DHB-CoA [mitochondrial matrix]", "crossref": [ { "id": "90176", "database": "ChEBI", "url": "" }, { "id": "ZINC000198019174", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9750005", "participant_name": "gentisuric acid [mitochondrial matrix]", "crossref": [ { "id": "88742", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9971077", "participant_name": "phenylacetyl-Gly [mitochondrial matrix]", "crossref": [ { "id": "60874", "database": "ChEBI", "url": "" }, { "id": "ZINC000000136391", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9972914", "participant_name": "PAH [cytosol]", "crossref": [ { "id": "ZINC000000119344", "database": "ZINC", "url": "" }, { "id": "64703", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9972915", "participant_name": "PABA-CoA [cytosol]", "crossref": [ { "id": "188497", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MPE2", "gene_name": "GLYAT", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1MPE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPE2" } ] } ] }, { "uniprot_ac": "E1B7T8", "gene_name": "GLYATL2", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "E1B7T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ] } ] }, { "uniprot_ac": "E1BI09", "gene_name": "GLYATL3", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI09-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 287, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI09-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI09" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09" }, { "id": "PF08444", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08444" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycine N-acyltransferase C-terminal", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 278, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI09" }, { "id": "PF06021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycine N-acyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 188, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI11-1", "uniprot_ac": "E1BI11", "uniprot_id": "E1BI11_BOVIN", "mass": { "chemical_mass": 120962.0, "monoisotopic_mass": 120962.0 }, "refseq": { "ac": "XP_005212177", "name": "mitotic deacetylase-associated SANT domain protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212177" }, "gene_names": [ { "name": "MIDEAS", "type": "recommended", "evidence": [ { "id": "E1BI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ] }, { "name": "MIDEAS", "type": "synonym", "evidence": [ { "id": "XP_005212177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212177" } ] } ], "protein_names": [ { "name": "Mitotic deacetylase associated SANT domain protein", "type": "synonym", "evidence": [ { "id": "E1BI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI11/entry#names_and_taxonomy" } ] }, { "name": "mitotic deacetylase-associated SANT domain protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212177" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIDEAS", "url": "https://www.uniprot.org/uniprotkb/E1BI11", "locus": { "chromosome": "10", "start_pos": 85126442, "end_pos": 85146326, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009272", "url": "https://www.ensembl.org/id/ENSBTAG00000009272" } ] } } ], "crossref": [ { "id": "E1BI11", "url": "https://alphafold.ebi.ac.uk/entry/E1BI11", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009272", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009272", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505848", "url": "https://www.ncbi.nlm.nih.gov/gene/505848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505848", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TAKCGVE", "url": "https://omabrowser.org/oma/group/TAKCGVE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI11", "url": "https://www.orthodb.org/?gene=E1BI11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212177", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI11-1", "url": "https://www.uniprot.org/uniprotkb/E1BI11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLQAQPKAQNKRKRCLFGDQEPAPKEQPQPLQAPQQPPAPPQSRVKEEPYFAHEGSAGAAPHSQPVELPSSNSLALLNSVVYGSERTMLSQQVGSVKWPNSVMAPGRGPERGGGGGVSDSGWQQQPGQPPPNSTWNRHSLPLYSGPKGSSHPGMGVATYYNHPEPLKLEKVGGPQLDRYGNAVRPMVPPKVQLEVGRSQAPLNSFHMAKKPPNQTLPLESFRQAFGHQVNRQVFRQGPPPPNPVTAFPPQKQQQQQQQQQAALPQIQLLENFYSMQQPPPSQQPQDFGLQPAGPLGQSHLAHHSMAPYHFPPNPDMNPELRKALLQESAPQPVLPQAQIAFPRRSRRLSKEGVLPSTALDGAGTQPGQEPASNLFLHHWVPQQPPPGPLGQPHPEALGFTLELRESQFLSDGERLAPNGRERETPAMGGEEGMRAVGTGDCGQVLRGGVIQSTRRRRRASQEANLLTLAQKAVELASLQNTKDASGSEEKRKSVLASTTKCGVEFSEPALAKRAREDSGMVPLIIPVSVPVRAVDPTEAAQAGGVDEDGKGPEQHPAEHKPSVIVTRRRSTRIPGTDAPAQPEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIMSTSSIPAPPPITPKSAHRTLLRSNSAEVTPPVLSVMGEATPVSIEPRINVGSRFQAEIPSMRDRALAAADPHKADLVWQPWEVLESSREKQRQVEDLLTAACSSIFPGAGTNQELALHCLHESRGDILETLNKLLLKKPLRPHNHPLATYHYTGSDQWKMAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDVDTSDEKSAQEEVEVDIKTSQKFPRVPPPRRESPNEERLEPKKEEKETRKEGEEEMPETQDKGEQEEGRERSRRAAAVKATQTLQANESANDILILRSHESNAPGSAGGQASEKPREGPGKSRRALPFSEKKKKTETFNKTQNQENTFPCKKCGRVFFKVKSRSAHMKSHAEQEKKAAALRQKEKEAAAAAATAAASPHQPALREESGAGERG", "length": 1102, "header": "tr|E1BI11-1|E1BI11_BOVIN Isoform 1 of Mitotic deacetylase associated SANT domain protein OS=Bos taurus OX=9913 GN=MIDEAS PE=4 SV=2 CANONICAL=E1BI11-1" }, "isoforms": [ { "isoform_ac": "E1BI11-1", "url": "https://www.uniprot.org/uniprotkb/E1BI11/entry#E1BI11-1", "sequence": { "sequence": "MNLQAQPKAQNKRKRCLFGDQEPAPKEQPQPLQAPQQPPAPPQSRVKEEPYFAHEGSAGAAPHSQPVELPSSNSLALLNSVVYGSERTMLSQQVGSVKWPNSVMAPGRGPERGGGGGVSDSGWQQQPGQPPPNSTWNRHSLPLYSGPKGSSHPGMGVATYYNHPEPLKLEKVGGPQLDRYGNAVRPMVPPKVQLEVGRSQAPLNSFHMAKKPPNQTLPLESFRQAFGHQVNRQVFRQGPPPPNPVTAFPPQKQQQQQQQQQAALPQIQLLENFYSMQQPPPSQQPQDFGLQPAGPLGQSHLAHHSMAPYHFPPNPDMNPELRKALLQESAPQPVLPQAQIAFPRRSRRLSKEGVLPSTALDGAGTQPGQEPASNLFLHHWVPQQPPPGPLGQPHPEALGFTLELRESQFLSDGERLAPNGRERETPAMGGEEGMRAVGTGDCGQVLRGGVIQSTRRRRRASQEANLLTLAQKAVELASLQNTKDASGSEEKRKSVLASTTKCGVEFSEPALAKRAREDSGMVPLIIPVSVPVRAVDPTEAAQAGGVDEDGKGPEQHPAEHKPSVIVTRRRSTRIPGTDAPAQPEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIMSTSSIPAPPPITPKSAHRTLLRSNSAEVTPPVLSVMGEATPVSIEPRINVGSRFQAEIPSMRDRALAAADPHKADLVWQPWEVLESSREKQRQVEDLLTAACSSIFPGAGTNQELALHCLHESRGDILETLNKLLLKKPLRPHNHPLATYHYTGSDQWKMAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDVDTSDEKSAQEEVEVDIKTSQKFPRVPPPRRESPNEERLEPKKEEKETRKEGEEEMPETQDKGEQEEGRERSRRAAAVKATQTLQANESANDILILRSHESNAPGSAGGQASEKPREGPGKSRRALPFSEKKKKTETFNKTQNQENTFPCKKCGRVFFKVKSRSAHMKSHAEQEKKAAALRQKEKEAAAAAATAAASPHQPALREESGAGERG", "length": 1102, "header": "tr|E1BI11-1|E1BI11_BOVIN Isoform 1 of Mitotic deacetylase associated SANT domain protein OS=Bos taurus OX=9913 GN=MIDEAS PE=4 SV=2 CANONICAL=E1BI11-1" }, "locus": { "chromosome": "10", "start_pos": 85146127, "end_pos": 85127446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012216.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012216.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012216.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012216.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 538, "start_aa": "Thr", "end_pos": 538, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr538", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505848", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505848", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZM69-1", "protein_name": "Mitotic deacetylase associated SANT domain protein", "gene_name": "ELMSAN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNLQAQQKSSTKRTGKRITYFNEQDITVSSKEPQQQLKEGQYYGHGGNIPASQTMEIPHTAGLTSATSNVALMNSVYSQDRGESMMMSQPVTAVKWQNSLMGNRLPERGDTHWQSPSAMWNHSMVFGSNPKGPHANAGAPGFYGHPEALKRNQEKGVFVSQMDLYEDAVQQMMSQKAQLEQQALVRQQAQINSFHQMQKQQQQNQSLPLQPFQLAFGHQGQKQGLPELLHVFQEAPASSTPAFTAQQKQQALPQLQLFENFYPQQQQQQQAATQAFGLQQTTSIAQPHVAAAAPQHHMMAHQFQQTERNQELFKALTEQNQQTVLPQTQIPFPRRSRRLSKEGVLVTSTGEALAAKQAEEQSGNLFLHHWQTHQQEVPLQQPLESLTHNKSSYSHPKRMDQGQKDVLANSELCHVETDRHTIAQNGRDAEKQTVAAEENAPRTNDFQGVRGGVIQSTRRRRRVSQEANLLTLAQKAVELASLQDVKESDTSEDKKSVLIAAPGPTAAKSVVEFASSSPAPKKAREDSSLVPLIIPVSVPVRKIDLQNLEKEKSEDGKLQRGQTNDRTPCERKPSVIVTRRRSNRNTNMETSNQHEHAVPKDETEGFARKPKQRPRPEPLFIPPKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSDRNFELPPYTPPPILSPVREGSGLYFNAILSSSGHPVPPPMTPKSSHRTLLRSNSSEVTPPVLSVVGEATPVSIEPRINVGTRFQAEIPSLQDRSLAAADEHKAELVWQPWGDLETNRVTQQNVESLLAAACSSIFPGGGTNQELALHFLHEEKGSVLGALSKLLLKGPVRSSTHPLADYHYTGSDSWKVAEKKLFNKGIAIYKKDFFLVQKLIKTKTVAQCVEFYYTYKKQVKIGRNGTLIFGDIDVANEKSVRDEAEVDIKSSHRFARVLPLRRDFFSEEQGHLEEEEEEAEEAEEGLDNRKKSTLLFKDEQTLQDDLIASDANIRSREATVTGRIGRRPRETTMKPRKLIPAPVQRRRRKQKMKSDVTSKIQNTENTFPCKKCGRVFYKVKSRSAHMKSHAEQEKKAAALKQQEREAAAAAEAAAAAAHSQAQQEESSESGSNSSGSSSGSSDEDGEI", "length": 1116 }, "evidence": [ { "id": "E1BI11", "url": "https://omabrowser.org/oma/group/E1BI11/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ACA6-1", "protein_name": "Mitotic deacetylase associated SANT domain protein", "gene_name": "Mideas", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNLQAQSKAQNKRKRCPYGDQEPAAKEQPPPLQAPPQSLRAKEEQYGPHEGPAGVASTTQPVELSPPNNLALLNSVVYGSERTTAAMLSQQAQVSSVKWPNSVMTPGRGLECGGGAGISDSGWQQQPGQPPPHSTWNHLPLYSGPKGGPHPGVGVSPYYNHAEALKGNKPGGPQLDHYGNAVQPMVPQKMQLEVGRPQAPLNSYHSAKKPPNQTLPLQPFQLAFGHQVNRQVFRQGPQPSNPTTSFPPQKQQQQQQQQQPPAALPHMQLFENYYPMHQPPSQQHQDFTLAPGGPLGQTHLPHRGMAPYPFPHNPELRKALLQDPASQPVLPQPQMAFPRRSRRLSKEGILPSNSLDGAGTQPGQEPTSNLFLHHWSLQQPPPGALGQPHSEALGFPLELRESQLLVDGDRLAPNGREREAPAVGNEEVSRAGGLGDCGQMMRSGVIQSTRRRRRASQEANLLTLAQKAVELASLQDANGSEEKRKSVLASTAKCGVEFSEPASAAKRAREESGMVPLIIPVSVPVRTVGPTEVAQVGGSDEDGKGLEQFPTDHKPSVIVTRRRSTRVPGTDTAAQAEDLNAKLEGEPSMRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAILSTSNVPAPPPITPKSAHRTLLRSNSSEVTPPVLSVMGEATPVSIEPRINVGTRFQAEIPTMRDRSLAAADPHKADLVWQPWEHLESSWEKQRQVDDLLTAACSSIFPGAGTNQELALHYLHESRGDILEALNKLLLKKPLRPHNHPLATYHYTGSDEWKMAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDLDTGAEKSGQEEVEVDVKTSQKFPRVLPPRRESPSEERLEPKREMKEPKKEGEEEVPDTQEKGEQEEGRERSRRAAAVKATQTLQPTEAANDVLILRSHEPNAPGSASVQTSEKPREGPGKSRRALPFTEKKKKPEAFNKTQNQENTFPCKKCGRVFYKVKSRSAHMKSHAEQEKKAAALRLKEKEAAAAAAHQQALKEESGEGEKG", "length": 1089 }, "evidence": [ { "id": "E1BI11", "url": "https://omabrowser.org/oma/group/E1BI11/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q2I4-1", "protein_name": "Mitotic deacetylase associated SANT domain protein", "gene_name": "Mideas", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNLQAQSKAQSKRKRCPFGDQEPAAKEQPPPLQSPPQSLRAKEEQYGAHEGPTGVASTTQPVELSPPNNLALLNSVVYGSERTTAAMLSQQAQVSSVKWPSSVMAPGRGLERGGGGGISDSGWQQQPGQPPPHSTWNHLPLYGGPKGSPHPGVGVPPYYNHPEALKGNKPGGPQLDHYGNAVQPMVPQKVQLEVGRPQAPLNSFHAAKKPPNQTLPLQPFQLAFGHQVNRQVFRQGPQPSNPTASFPPQKQQQQQQPAALPQMQLFENYYPMHQLPSQQHQDFGLAPGGPLGQTHLAHRSMAPYPFSHNPDMNPELRKALLQDPASQPVLPQPQMAFPRRSRRLSKEGILPSNSLDGAGTQPGQEPASNLFLHHWSLPQPPPGTLGQPHSEALGFPLELRESQMLADGDRLAPNGREREPPAMGNEEVMRAGGLGDCGQMIRSGVIQSTKRRRRVSQEANLLTLAQKAVELASMQDANGSEEKRKSVLATTSRCGVEFSEPALAAKRAREESGMVPLIIPVSVPVRTVGPTEVAQVGGADEDGTGLEQYPTEHKPSVIVTRRRSTRVPGTDAAAQAEDLNVKLEGEPSMRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFEPPPYTPPPILSPVREGSGLYFNAIISTSNIPAPPPITPKSAHRTLLRSNSSEVTPPVLSVMGEATPVSIEPRINVGTRFQAEIPMMRDRALAAFDPHKADLVWQPWEHLESSWEKQRQVDDLLTAACSSIFPGAGTNQELALHYLHESRGDILEALNKLLLRKPLRPHNHPLATYHYTGSDQWKTAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDLDIGDEKSGQEEVEVDVKTSQKFPRVPPPRRESPSEERLEPKREVTEPRKEGEEEVPDTQEKGEQEEGRERCRRAAAVKATQTLQANEAANDVLILRSHEPNAPGSAGIQTSEKPREGPGKSRRALPFTEKKKKAEAFNKTQNQENTFPCKKCGRVFYKVKSRSAHMKSHAEQEKKAAALRLKEKEAAAAAAHQQALREESGEGEKG", "length": 1089 }, "evidence": [ { "id": "E1BI11", "url": "https://omabrowser.org/oma/group/E1BI11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1S3I8-1", "protein_name": "Mitotic deacetylase associated SANT domain protein", "gene_name": "MIDEAS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNLQAQPKAQNKRKRCLFGDQEPAPKEQPQALQAPQQPPAPPQSTRVKEEPYFGQEGPAGAVPASQPVELPPPNSLALLNSVVYGSERTMLSQQMGSVKWPNSVMAPGRGPERGGGGGVSDSGWQQQPGQPPPHSTWNRHSLPLYSGPKGSPHPGMGVSTYYNHPEALKREKGGGPQLDRYGNAVRPMMPQKVQLDVGQPQAPLNSFHVAKKPPNQTLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQQAALPQMQLFDNFYPMQQPPSQQPQDFGLQPGGPLGQSHLAHHSMAPYPFPPNPDLNPELRKALLQESAPQPVLPQAQIAFPRRSRRLSKEGVLPSTALDGAGTQPGQEPASNLFLHHWPPQQPPPGPLGQPHPEALRFPLELRESQLLSDGDRLAPNGRERDAPAMGNEEGVRAVGTGDCGQVLRGGVIQSTRRRRRASQEANLLTLAQKAVELASLQNTKDANGSEEKRKSVLASTAKCGVEFSEPSLAAKRAREDSGMVPLIIPVSVPVRAVDPTEAAQAGGVDEDGRGPEQNPAEHKPSVIVTRRRSTRIPGTDAPAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYTPPPLSPVREGSGLYFNAIMSTSSIPAPPPITPKSAHRTLLRSNSAEVTPPVLSVMGEATPVSIEPRINVGSRFQAEIPLMRDRALAAADPHKADLVWQPWENLESSREKQRQVEDLLTAACSSIFPGAGTNQELALHCLHESRGDILEALNKLLLKKPLRPHNHPLATYHYTGSDQWKAAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDVDTSDEKSAQEEVEVDIKTSQKFPRVPPPRRESPSEERLEPRKEVKETRKEGEEELPETQEKGEQEEGRERSRRAAAVKATQTLQANESANDILILRSHESNAPGSAGCQASEKPREGPGKSRRALPFSEKKKKPETFNKTQNQENTFPCKKCGRVFYKVKSRSAHMKSHAEQEKKAAALRQKEKEAAAAAATVAAASPHQPALREESGAGERG", "length": 1101 }, "evidence": [ { "id": "E1BI11", "url": "https://omabrowser.org/oma/group/E1BI11/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PJG2-1", "protein_name": "Mitotic deacetylase-associated SANT domain protein", "gene_name": "MIDEAS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQQVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVRPMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPLFENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSALDGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGVIQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTEAAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIEPRINVGSRFQAEIPLMRDRALAAADPHKADLVWQPWEDLESSREKQRQVEDLLTAACSSIFPGAGTNQELALHCLHESRGDILETLNKLLLKKPLRPHNHPLATYHYTGSDQWKMAERKLFNKGIAIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDVDTSDEKSAQEEVEVDIKTSQKFPRVPLPRRESPSEERLEPKREVKEPRKEGEEEVPEIQEKEEQEEGRERSRRAAAVKATQTLQANESASDILILRSHESNAPGSAGGQASEKPREGTGKSRRALPFSEKKKKTETFSKTQNQENTFPCKKCGR", "length": 1045 }, "evidence": [ { "id": "E1BI11", "url": "https://omabrowser.org/oma/group/E1BI11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "E1BI11", "url": "https://www.uniprot.org/uniprotkb/E1BI11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1028, "end_pos": 1030, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 882, "end_pos": 884, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI11-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1102, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI11-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI11" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI11" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 1037, "end_pos": 1064, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI11" }, { "id": "PS51156", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELM2", "eco_id": "ECO_0000259", "start_pos": 720, "end_pos": 812, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI11" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 827, "end_pos": 878, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 538 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1028, "end_pos": 1030 }, { "start_pos": 133, "end_pos": 135 }, { "start_pos": 214, "end_pos": 216 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 882, "end_pos": 884 }, { "start_pos": 976, "end_pos": 978 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI27-1", "uniprot_ac": "E1BI27", "uniprot_id": "E1BI27_BOVIN", "mass": { "chemical_mass": 34890.0, "monoisotopic_mass": 34890.0 }, "refseq": { "ac": "NP_001377100", "name": "olfactory receptor family 1 subfamily A member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100" }, "gene_names": [ { "name": "OR1A1", "type": "recommended", "evidence": [ { "id": "E1BI27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ] }, { "name": "OR1A1", "type": "synonym", "evidence": [ { "id": "NP_001377100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 1 subfamily A member 1", "type": "synonym", "evidence": [ { "id": "E1BI27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI27/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1A1", "type": "synonym", "evidence": [ { "id": "NP_001377100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100" } ] }, { "name": "olfactory receptor family 1 subfamily A member 1", "type": "synonym", "evidence": [ { "id": "NP_001377100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1A1", "url": "https://www.uniprot.org/uniprotkb/E1BI27", "locus": { "chromosome": "19", "start_pos": 23928920, "end_pos": 23929858, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060058", "url": "https://www.ensembl.org/id/ENSBTAG00000060058" } ] } } ], "crossref": [ { "id": "E1BI27", "url": "https://alphafold.ebi.ac.uk/entry/E1BI27", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540082", "url": "https://www.ncbi.nlm.nih.gov/gene/540082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540082", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEDFFFT", "url": "https://omabrowser.org/oma/group/QEDFFFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI27", "url": "https://www.orthodb.org/?gene=E1BI27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001377100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377100", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI27-1", "url": "https://www.uniprot.org/uniprotkb/E1BI27-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREDNQSSTFNFILLGVTGQQKQEDFFFLLFLFIYPTTLIGNLLIILAICSDIRLHNPMYFLLANLSFVDIFFSSVTIPKMLANHLLGSKAISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAITRPLHYTTIMSPWTCVLLVIGSWVVGNGNALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYNLKDAVITVMYIAVTPMLNPFIYSLRNRDMKAALGKLFSRRIFSQPM", "length": 312, "header": "tr|E1BI27-1|E1BI27_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1 OS=Bos taurus OX=9913 GN=OR1A1 PE=3 SV=3 CANONICAL=E1BI27-1" }, "isoforms": [ { "isoform_ac": "E1BI27-1", "url": "https://www.uniprot.org/uniprotkb/E1BI27/entry#E1BI27-1", "sequence": { "sequence": "MREDNQSSTFNFILLGVTGQQKQEDFFFLLFLFIYPTTLIGNLLIILAICSDIRLHNPMYFLLANLSFVDIFFSSVTIPKMLANHLLGSKAISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAITRPLHYTTIMSPWTCVLLVIGSWVVGNGNALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYNLKDAVITVMYIAVTPMLNPFIYSLRNRDMKAALGKLFSRRIFSQPM", "length": 312, "header": "tr|E1BI27-1|E1BI27_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1 OS=Bos taurus OX=9913 GN=OR1A1 PE=3 SV=3 CANONICAL=E1BI27-1" }, "locus": { "chromosome": "19", "start_pos": 23929858, "end_pos": 23928923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046043.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046043.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043371.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043371.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 280, "start_aa": "Thr", "end_pos": 280, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540082", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540082", "resource": "KEGG Pathway" }, { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I9I9-1", "protein_name": "Olfactory receptor 1A1", "gene_name": "LOC100766740", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MREENESSSTDFTLLGVTRQREQEYFFFILFLFIYPITVIGNTLIILAIHSDTRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCLAQMYFMIALANTDSYILAAMAYDRAVAISRPLHYATIMSPRPCVLLVVGSWVIGNANALPHTILTASLSFCGNKDVANFYCDITPLLQLSCSDIHFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRAPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLNSYSLKHALITVMYTAVTPMLNPFIYSLRNRDMKAALRKLFCHGASSSPM", "length": 312 }, "evidence": [ { "id": "E1BI27", "url": "https://omabrowser.org/oma/group/E1BI27/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7TRX2-1", "protein_name": "Olfactory receptor family 1 subfamily A member 1", "gene_name": "Or1a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MREENESSTIDFTLLGVTRQREQEYFFFILFLFIYPITVFGNMLIILAIHSDTRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCMAQMYFMISLGNTDSYILAAMAYDRAVAISRPLHYATIMSPQLCVLLVAGSWVIANANALPHTLLTARLSFCGNKDVANFYCDITPLLQLSCSDIRFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRVPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKHALITVMYTAVTPMLNPFIYSLRNRDMKAALKKLFHCHSSSSSLM", "length": 313 }, "evidence": [ { "id": "E1BI27", "url": "https://omabrowser.org/oma/group/E1BI27/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P1Q5-1", "protein_name": "Olfactory receptor 1A1", "gene_name": "OR1A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRENNQSSTLEFILLGVTGQQEQEDFFYILFLFIYPITLIGNLLIVLAICSDVRLHNPMYFLLANLSLVDIFFSSVTIPKMLANHLLGSKSISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFHVKMMYLGVGIFSVPLLCIIVSYIRVFSTVFQVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGTYFRPLTNYSLKDAVITVMYTAVTPMLNPFIYSLRNRDMKAALRKLFNKRISS", "length": 309 }, "evidence": [ { "id": "E1BI27", "url": "https://omabrowser.org/oma/group/E1BI27/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BI27", "url": "https://www.uniprot.org/uniprotkb/E1BI27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI27-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI27-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI27" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI27" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 280 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI65-1", "uniprot_ac": "E1BI65", "uniprot_id": "E1BI65_BOVIN", "mass": { "chemical_mass": 26081.0, "monoisotopic_mass": 26081.0 }, "refseq": { "ac": "NP_001179245", "name": "receptor-transporting protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179245" }, "gene_names": [ { "name": "RTP2", "type": "recommended", "evidence": [ { "id": "E1BI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ] }, { "name": "RTP2", "type": "synonym", "evidence": [ { "id": "NP_001179245", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179245" } ] } ], "protein_names": [ { "name": "Receptor transporter protein 2", "type": "synonym", "evidence": [ { "id": "E1BI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI65/entry#names_and_taxonomy" } ] }, { "name": "receptor-transporting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179245", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179245" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTP2", "url": "https://www.uniprot.org/uniprotkb/E1BI65", "locus": { "chromosome": "1", "start_pos": 79633348, "end_pos": 79629397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003179", "url": "https://www.ensembl.org/id/ENSBTAG00000003179" } ] } } ], "crossref": [ { "id": "E1BI65", "url": "https://alphafold.ebi.ac.uk/entry/E1BI65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003179", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003179", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539817", "url": "https://www.ncbi.nlm.nih.gov/gene/539817", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539817", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSWELIM", "url": "https://omabrowser.org/oma/group/DSWELIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI65", "url": "https://www.orthodb.org/?gene=E1BI65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14402:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14402:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13695", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13695", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179245", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI65-1", "url": "https://www.uniprot.org/uniprotkb/E1BI65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPNELAPGWKQYLEQHASGRFHCTWCWHTWQSANVVILYHMYLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIENLVDNLITSLREQCYDEDGGQYRIHVASRPDSGPHRSEFCEACQEGIVHWKPSEKLLEEEVTFSGASKSRAQEGSGYNFFSLRWCLFWASLCLLIVYLQFSFRRSTFL", "length": 223, "header": "tr|E1BI65-1|E1BI65_BOVIN Isoform 1 of Receptor transporter protein 2 OS=Bos taurus OX=9913 GN=RTP2 PE=4 SV=1 CANONICAL=E1BI65-1" }, "isoforms": [ { "isoform_ac": "E1BI65-1", "url": "https://www.uniprot.org/uniprotkb/E1BI65/entry#E1BI65-1", "sequence": { "sequence": "MCTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPNELAPGWKQYLEQHASGRFHCTWCWHTWQSANVVILYHMYLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIENLVDNLITSLREQCYDEDGGQYRIHVASRPDSGPHRSEFCEACQEGIVHWKPSEKLLEEEVTFSGASKSRAQEGSGYNFFSLRWCLFWASLCLLIVYLQFSFRRSTFL", "length": 223, "header": "tr|E1BI65-1|E1BI65_BOVIN Isoform 1 of Receptor transporter protein 2 OS=Bos taurus OX=9913 GN=RTP2 PE=4 SV=1 CANONICAL=E1BI65-1" }, "locus": { "chromosome": "1", "start_pos": 79633345, "end_pos": 79629615, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004128.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004128.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004128.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004128.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539817", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539817", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZCW1-1", "protein_name": "Receptor (chemosensory) transporter protein 2", "gene_name": "Rtp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPNELGPGWKQYLEQHASGRFHCSWCWHTWQSANVVILFHMHLDRAQRVGSVRMRVFKQLCYQCGTSRLDESSMLEENIEGLVDNLITSLREQCYDEDGGQYRIHVASRPDTGLHRSEFCEACQEGIVHWKPSEKLLEEDAAFTDDSKRKGQAGFISDFFSFRWCLFWGALCLVIVYLQFFRGRSGFL", "length": 223 }, "evidence": [ { "id": "E1BI65", "url": "https://omabrowser.org/oma/group/E1BI65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SFH9-1", "protein_name": "Receptor transporter protein 2", "gene_name": "RTP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCTSLTTCEWKKVFYEKMEVAKPNDSWELIIDPNLKPNELAPGWKQYLEQHASGRFHCTWCWHTWQSANVVILFHMHLDRPQRMGSVRMRVFKQLCYECGTSRLDESSMLEENVESLVDNLITSLREQCYDEDGGQYRIHVATRPDSGSHRSEFCEACQEGIVHWKPSEKLLEEEATFSGASKPRAQESSGYNFFSLRWCLFWASLCLLIVYLQFSFRSSAFL", "length": 223 }, "evidence": [ { "id": "E1BI65", "url": "https://omabrowser.org/oma/group/E1BI65/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GT92-1", "protein_name": "Receptor-transporting protein 2", "gene_name": "Rtp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPNELGPGWKQYLEQHASGRFHCSWCWHTWQSANVVILFHMHLDRAQRVGSVRMRVFKQLCYQCGTSRLDESSMLEENIEGLVDNLITSLREQCYDEDGGQYRIHVASRPDSGLHRSEFCEACQEGIVHWKPSEKLLEEDASYTDASKRKAQGSFVYNFFSFRWCLFWGVLCLVIVYLQFFRGRSSFL", "length": 223 }, "evidence": [ { "id": "E1BI65", "url": "https://omabrowser.org/oma/group/E1BI65/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5QGT7-1", "protein_name": "Receptor-transporting protein 2", "gene_name": "RTP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPSELAPGWKQYLEQHASGRFHCSWCWHTWQSAHVVILFHMFLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYEEDGGQYRIHVASRPDSGPHRAEFCEACQEGIVHWKPSEKLLEEEVTTYTSEASKPRAQAGSGYNFLSLRWCLFWASLCLLVVYLQFSFLSPAFF", "length": 225 }, "evidence": [ { "id": "E1BI65", "url": "https://omabrowser.org/oma/group/E1BI65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80ZI2-1", "protein_name": "Receptor-transporting protein 2", "gene_name": "Rtp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTSLTTCEWKKVFYEKMEVAKPADSWELIIDPTLKPNELGPGWKQYLEQHASGRFHCSWCWHTWQSANVVILFHMHLDRAQRVGSVRMRVFKQLCYQCGTSRLDESSMLEENIEGLVDNLITSLREQCYDEDGGQYRIHVASRPDSGLHRSEFCEACQEGIVHWKPSEKLLEEDAAYTDASKKKGQAGFISSFFSFRWCLFWGTLCLVIVYLQFFRGRSGFL", "length": 223 }, "evidence": [ { "id": "E1BI65", "url": "https://omabrowser.org/oma/group/E1BI65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" }, { "name": "olfactory receptor binding", "id": "GO:0031849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031849", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" }, { "name": "protein insertion into membrane", "id": "GO:0051205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051205", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "E1BI65", "url": "https://www.uniprot.org/uniprotkb/E1BI65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI65-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI65-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI65" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI65" }, { "id": "SM01328", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01328" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3CxxC-type", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 161, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI66-1", "uniprot_ac": "E1BI66", "uniprot_id": "E1BI66_BOVIN", "mass": { "chemical_mass": 76891.0, "monoisotopic_mass": 76891.0 }, "refseq": { "ac": "XP_005212910", "name": "calpain-13 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212910" }, "gene_names": [ { "name": "CAPN13", "type": "recommended", "evidence": [ { "id": "E1BI66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ] }, { "name": "CAPN13", "type": "synonym", "evidence": [ { "id": "XP_005212910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212910" } ] } ], "protein_names": [ { "name": "Calpain-13", "type": "recommended", "evidence": [ { "id": "E1BI66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI66/entry#names_and_taxonomy" } ] }, { "name": "Calcium-activated neutral proteinase 13", "type": "synonym", "evidence": [ { "id": "E1BI66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI66/entry#names_and_taxonomy" } ] }, { "name": "calpain-13 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212910" } ] } ], "function": [ { "annotation": "Probable non-lysosomal thiol-protease.", "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66#function" }, { "database": "UniProtKB", "id": "ARBA00059312", "url": "https://www.uniprot.org/uniprotkb/ARBA00059312#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAPN13", "url": "https://www.uniprot.org/uniprotkb/E1BI66", "locus": { "chromosome": "11", "start_pos": 69152055, "end_pos": 69068510, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008946", "url": "https://www.ensembl.org/id/ENSBTAG00000008946" } ] } } ], "crossref": [ { "id": "E1BI66", "url": "https://alphafold.ebi.ac.uk/entry/E1BI66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008946", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008946", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00044", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00044", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526038", "url": "https://www.ncbi.nlm.nih.gov/gene/526038", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BI66", "url": "https://www.orthodb.org/?gene=E1BI66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MVZ7", "url": "https://www.orthodb.org/?gene=F1MVZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10183", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10183", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10183:SF333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10183:SF333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1474228", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474228", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005212910", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI66-1", "url": "https://www.uniprot.org/uniprotkb/E1BI66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVZ7", "url": "https://www.uniprot.org/uniprotkb/F1MVZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVZ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MVZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHNQQFPAKTPIIKFKEQDFYSLRDHCLNRGLLFEDETFPAETYSIGLQLLKGKNLSNLSWMRPKDLLKGKSEPLFILEGASRFDIQQGEAGDCWFLAALGALTQSPQYLQKILIDQSFSYQYAGIFHFRFWRCGQWVEVVIDDRLPVLNNEYLFVKPRNKREFWPCLLEKAYAKFHGSYANLHYGYLPDALVDLTGGVVTNISLHSSSSDLMTMVKTAAEAGSLMTCSTLAGPTSESVTMANGLVSRHAYTVTGAEQIEYRRSWEYLIRLWNPWGKIEWRGRWSDWSPEWQETHDQRKSQLYEDKDNGEFWMSCQDFRDNFFGLFICNQVPISLDHGSTPHERWSQMMFKDHLIPGNTEGYQRGMQYIFSVPDSMENNNVIMSFNIGPQNLKAKDRTFPLKYEVFKVDYQFQHFQDRLPSTFFSQFRIAEKGIVSETTCNLTECFSLSPGTYVVVVSEGREAVEFLLRIFLKMPNSDRNLDGSLNLRALQASLPENGSQQSIFYKYAQQGLDIDATQLQSLLNREFLRGPPGDPFSLDECRSLVALMDLKVNGRLDQEEFSRLWSRLVHCQSVFQNSPKNAGVFLSSDLWKAIRDTDFLAGISITSELLDLMKLRYSDSTGRVSFPSLVCLLMRLEAMAKAFQNLSKDGKGLYLTEMEWMNLVMYN", "length": 668, "header": "tr|E1BI66-1|E1BI66_BOVIN Isoform 1 of Calpain-13 OS=Bos taurus OX=9913 GN=CAPN13 PE=3 SV=3 CANONICAL=E1BI66-1" }, "isoforms": [ { "isoform_ac": "E1BI66-1", "url": "https://www.uniprot.org/uniprotkb/E1BI66/entry#E1BI66-1", "sequence": { "sequence": "MAHNQQFPAKTPIIKFKEQDFYSLRDHCLNRGLLFEDETFPAETYSIGLQLLKGKNLSNLSWMRPKDLLKGKSEPLFILEGASRFDIQQGEAGDCWFLAALGALTQSPQYLQKILIDQSFSYQYAGIFHFRFWRCGQWVEVVIDDRLPVLNNEYLFVKPRNKREFWPCLLEKAYAKFHGSYANLHYGYLPDALVDLTGGVVTNISLHSSSSDLMTMVKTAAEAGSLMTCSTLAGPTSESVTMANGLVSRHAYTVTGAEQIEYRRSWEYLIRLWNPWGKIEWRGRWSDWSPEWQETHDQRKSQLYEDKDNGEFWMSCQDFRDNFFGLFICNQVPISLDHGSTPHERWSQMMFKDHLIPGNTEGYQRGMQYIFSVPDSMENNNVIMSFNIGPQNLKAKDRTFPLKYEVFKVDYQFQHFQDRLPSTFFSQFRIAEKGIVSETTCNLTECFSLSPGTYVVVVSEGREAVEFLLRIFLKMPNSDRNLDGSLNLRALQASLPENGSQQSIFYKYAQQGLDIDATQLQSLLNREFLRGPPGDPFSLDECRSLVALMDLKVNGRLDQEEFSRLWSRLVHCQSVFQNSPKNAGVFLSSDLWKAIRDTDFLAGISITSELLDLMKLRYSDSTGRVSFPSLVCLLMRLEAMAKAFQNLSKDGKGLYLTEMEWMNLVMYN", "length": 668, "header": "tr|E1BI66-1|E1BI66_BOVIN Isoform 1 of Calpain-13 OS=Bos taurus OX=9913 GN=CAPN13 PE=3 SV=3 CANONICAL=E1BI66-1" }, "locus": { "chromosome": "11", "start_pos": 69152021, "end_pos": 69094931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044473.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044473.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041966.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041966.4" } ] } }, { "isoform_ac": "F1MVZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BI66/entry#F1MVZ7-1", "sequence": { "sequence": "MAHNQQFPAKTPIIKFKEQDFYSLRDHCLNRGLLFEDETFPAETYSIGLQLLKGKNLSNLSWMRPKDLLKGKSEPLFILEGASRFDIQQGEAGDCWFLAALGALTQSPQYLQKILIDQSFSYQYAGIFHFRFWRCGQWVEVVIDDRLPVLNNEYLFVKPRNKREFWPCLLEKAYAKFHGSYANLHYGYLPDALVDLTGGVVTNISLHSSSSDLMTMVKTAAEAGSLMTCSTLAGPTSESVTMANGLVSRHAYTVTGAEQIEYRRSWEYLIRLWNPWGKIEWRGRWSDWSPEWQETHDQRKSQLYEDKDNGEFWMSCQDFRDNFFGLFICNQVPISLDHGSTPHERWSQMMFKDHLIPGNTEGYQRGMQYIFSVPDSMENNNVIMSFNIGPQNLKAKDRTFPLKYEVFKVRQYFQHFQDRLPSTFFSQFRIAEKGIVSETTCNLTECFSLSPGTYVVVVSEGREAVEFLLRIFLKMPNSDRQVFQKMGPSRAFSTSTLSRGWTLMLRSFRAFSTGNS", "length": 516, "header": "tr|F1MVZ7-1|F1MVZ7_BOVIN Computationally mapped isoform of Calpain 13 OS=Bos taurus OX=9913 GN=CAPN13 PE=3 SV=2 CANONICAL=E1BI66-1" }, "locus": { "chromosome": "11", "start_pos": 69143775, "end_pos": 69094931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011777.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011777.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011777.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011777.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 236, "start_aa": "Thr", "end_pos": 236, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr236", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1474228", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474228", "resource": "Reactome", "description": "Degradation of the extracellular matrix" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium-dependent cysteine-type endopeptidase activity", "id": "GO:0004198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004198", "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BI66", "url": "https://www.uniprot.org/uniprotkb/E1BI66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 668, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI66" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI66" }, { "id": "PS50203", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50203" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calpain catalytic", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 332, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BI66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI66" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 537, "end_pos": 572, "start_aa": "Phe", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 236 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 442, "end_pos": 444 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 646, "end_pos": 648 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI67-1", "uniprot_ac": "E1BI67", "uniprot_id": "E1BI67_BOVIN", "mass": { "chemical_mass": 36057.0, "monoisotopic_mass": 36057.0 }, "refseq": {}, "gene_names": [ { "name": "IL18BP", "type": "recommended", "evidence": [ { "id": "E1BI67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI67" } ] } ], "protein_names": [ { "name": "Interleukin-18-binding protein", "type": "recommended", "evidence": [ { "id": "E1BI67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI67/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI67", "url": "https://www.uniprot.org/uniprotkb/E1BI67" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL18BP", "url": "https://www.uniprot.org/uniprotkb/E1BI67", "locus": { "chromosome": "15", "start_pos": 51642355, "end_pos": 51639783, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027676", "url": "https://www.ensembl.org/id/ENSBTAG00000027676" } ] } } ], "crossref": [ { "id": "E1BI67", "url": "https://alphafold.ebi.ac.uk/entry/E1BI67", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027676", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027676", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617470", "url": "https://www.ncbi.nlm.nih.gov/gene/617470", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617470", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617470", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BI67", "url": "https://www.orthodb.org/?gene=E1BI67", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14292:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14292:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BI67", "url": "https://www.uniprot.org/uniprotkb/E1BI67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI67-1", "url": "https://www.uniprot.org/uniprotkb/E1BI67-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRLIGLVTSIMLKVERARWGSTSFVSRGWKSSSLRLMLVLQLSVGTGGWGRVDSVWQPPEKSDVGRGCGDHRKAVLVCLESVGEAVCHGHLPRLPREEVVTDIESKARQLLTQFIMTMRQNWIPDPSPLWALLFCAHIISHLARATPVPQATTAASPGMAKAPCSSRPLALPAAKQCPALTVTWPAEEVSLNGTLTLSCTACSRFPHFSILYWLGNGSFIEHLPGRLWEGSTRREYRGKWTQLWRPLVLEELSPTLQDTNFSCVFMDPGQTVQRHLVLAQLWAGPKTSVPLPQEAPPSSQSPLLHHPDGEPELHRHLVETPPLY", "length": 325, "header": "tr|E1BI67-1|E1BI67_BOVIN Isoform 1 of Interleukin-18-binding protein OS=Bos taurus OX=9913 GN=IL18BP PE=4 SV=3 CANONICAL=E1BI67-1" }, "isoforms": [ { "isoform_ac": "E1BI67-1", "url": "https://www.uniprot.org/uniprotkb/E1BI67/entry#E1BI67-1", "sequence": { "sequence": "MKRLIGLVTSIMLKVERARWGSTSFVSRGWKSSSLRLMLVLQLSVGTGGWGRVDSVWQPPEKSDVGRGCGDHRKAVLVCLESVGEAVCHGHLPRLPREEVVTDIESKARQLLTQFIMTMRQNWIPDPSPLWALLFCAHIISHLARATPVPQATTAASPGMAKAPCSSRPLALPAAKQCPALTVTWPAEEVSLNGTLTLSCTACSRFPHFSILYWLGNGSFIEHLPGRLWEGSTRREYRGKWTQLWRPLVLEELSPTLQDTNFSCVFMDPGQTVQRHLVLAQLWAGPKTSVPLPQEAPPSSQSPLLHHPDGEPELHRHLVETPPLY", "length": 325, "header": "tr|E1BI67-1|E1BI67_BOVIN Isoform 1 of Interleukin-18-binding protein OS=Bos taurus OX=9913 GN=IL18BP PE=4 SV=3 CANONICAL=E1BI67-1" }, "locus": { "chromosome": "15", "start_pos": 51642140, "end_pos": 51639982, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039864.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039864.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039650.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039650.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617470", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617470", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BI67", "url": "https://www.uniprot.org/uniprotkb/E1BI67" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "interleukin-18 binding", "id": "GO:0042007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042007", "evidence": [ { "database": "UniProtKB", "id": "E1BI67", "url": "https://www.uniprot.org/uniprotkb/E1BI67" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI67-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 325, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI67-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI67" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI67" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 179, "end_pos": 278, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 261, "end_pos": 263 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI71-1", "uniprot_ac": "E1BI71", "uniprot_id": "E1BI71_BOVIN", "mass": { "chemical_mass": 15436.0, "monoisotopic_mass": 15436.0 }, "refseq": { "ac": "NP_001193646", "name": "small integral membrane protein 24 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193646" }, "gene_names": [ { "name": "SMIM24", "type": "recommended", "evidence": [ { "id": "E1BI71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI71" } ] }, { "name": "C7H19orf77", "type": "synonym", "evidence": [ { "id": "NP_001193646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193646" } ] }, { "name": "SMIM24", "type": "synonym", "evidence": [ { "id": "NP_001193646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193646" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 24", "type": "synonym", "evidence": [ { "id": "E1BI71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI71/entry#names_and_taxonomy" } ] }, { "name": "small integral membrane protein 24 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193646" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI71", "url": "https://www.uniprot.org/uniprotkb/E1BI71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM24", "url": "https://www.uniprot.org/uniprotkb/E1BI71", "locus": { "chromosome": "7", "start_pos": 20436476, "end_pos": 20433050, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031383", "url": "https://www.ensembl.org/id/ENSBTAG00000031383" } ] } } ], "crossref": [ { "id": "E1BI71", "url": "https://alphafold.ebi.ac.uk/entry/E1BI71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031383", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031383", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510079", "url": "https://www.ncbi.nlm.nih.gov/gene/510079", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510079", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510079", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NPYQDES", "url": "https://omabrowser.org/oma/group/NPYQDES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI71", "url": "https://www.orthodb.org/?gene=E1BI71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15296:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15296:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193646", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI71", "url": "https://www.uniprot.org/uniprotkb/E1BI71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI71-1", "url": "https://www.uniprot.org/uniprotkb/E1BI71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTLGILLLLMGLLLSSVEAQKERQLKPWLVGLAAVVGFLFIVFILMLASRLWCSKARAEDEERPTLRMNPNPYEEVDLRKEDKKGKEEKEEKAEEKKAGKGEKAKKKGKRNFGLELEENEERRDYKKVRNTAM", "length": 134, "header": "tr|E1BI71-1|E1BI71_BOVIN Isoform 1 of Small integral membrane protein 24 OS=Bos taurus OX=9913 GN=SMIM24 PE=3 SV=3 CANONICAL=E1BI71-1" }, "isoforms": [ { "isoform_ac": "E1BI71-1", "url": "https://www.uniprot.org/uniprotkb/E1BI71/entry#E1BI71-1", "sequence": { "sequence": "MGTLGILLLLMGLLLSSVEAQKERQLKPWLVGLAAVVGFLFIVFILMLASRLWCSKARAEDEERPTLRMNPNPYEEVDLRKEDKKGKEEKEEKAEEKKAGKGEKAKKKGKRNFGLELEENEERRDYKKVRNTAM", "length": 134, "header": "tr|E1BI71-1|E1BI71_BOVIN Isoform 1 of Small integral membrane protein 24 OS=Bos taurus OX=9913 GN=SMIM24 PE=3 SV=3 CANONICAL=E1BI71-1" }, "locus": { "chromosome": "7", "start_pos": 20435676, "end_pos": 20433111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044465.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044465.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041958.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041958.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510079", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510079", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VSM1-1", "protein_name": "Small integral membrane protein 24", "gene_name": "SMIM24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPTRWGTGRAPALDLLRLQTCLPPYQGLGRVSPGSDQDCALQHPGCWFLGAMGTLETLLLLSALLLSPAEAQQASEYRLKPWLVGLAAVVGFLFIVFVLMLTNRLWCSKERAEDEEGSILRMNTNPYENVDLSKEGKKEKKEKEKKTNNNKKAEDKKSKKKGESNLGLELEEKEEPQDEEKVKNTAM", "length": 187 }, "evidence": [ { "id": "E1BI71", "url": "https://omabrowser.org/oma/group/E1BI71/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75264-1", "protein_name": "Small integral membrane protein 24", "gene_name": "SMIM24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METLGALLVLEFLLLSPVEAQQATEHRLKPWLVGLAAVVGFLFIVYLVLLANRLWCSKARAEDEEETTFRMESNLYQDQSEDKREKKEAKEKEEKRKKEKKTAKEGESNLGLDLEEKEPGDHERAKSTVM", "length": 130 }, "evidence": [ { "id": "E1BI71", "url": "https://omabrowser.org/oma/group/E1BI71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q0VG18-1", "protein_name": "Small integral membrane protein 24", "gene_name": "Smim24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTLGRLLLLATLFLTPAEAQQASERRLKPWLVGLAAVVGFLFIVFILMLANRVWCAKGRAEDEEATFRMEHIMNENSQPSKADKKQKKKVDRKGGQSNEALELEEKESSDEERGKKTAL", "length": 120 }, "evidence": [ { "id": "E1BI71", "url": "https://omabrowser.org/oma/group/E1BI71/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BI71", "url": "https://www.uniprot.org/uniprotkb/E1BI71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI71-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 134, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI71-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI71" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI77-1", "uniprot_ac": "E1BI77", "uniprot_id": "E1BI77_BOVIN", "mass": { "chemical_mass": 68995.0, "monoisotopic_mass": 68995.0 }, "refseq": { "ac": "XP_005214988", "name": "RBBP8 N-terminal-like protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214988" }, "gene_names": [ { "name": "RBBP8NL", "type": "recommended", "evidence": [ { "id": "E1BI77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI77" } ] }, { "name": "RBBP8NL", "type": "synonym", "evidence": [ { "id": "XP_005214988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214988" } ] } ], "protein_names": [ { "name": "RBBP8 N-terminal like", "type": "synonym", "evidence": [ { "id": "E1BI77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI77/entry#names_and_taxonomy" } ] }, { "name": "RBBP8 N-terminal-like protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214988" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI77", "url": "https://www.uniprot.org/uniprotkb/E1BI77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBBP8NL", "url": "https://www.uniprot.org/uniprotkb/E1BI77", "locus": { "chromosome": "13", "start_pos": 54852665, "end_pos": 54837627, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003163", "url": "https://www.ensembl.org/id/ENSBTAG00000003163" } ] } } ], "crossref": [ { "id": "E1BI77", "url": "https://alphafold.ebi.ac.uk/entry/E1BI77", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003163", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003163", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515877", "url": "https://www.ncbi.nlm.nih.gov/gene/515877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RCQVTQE", "url": "https://omabrowser.org/oma/group/RCQVTQE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI77", "url": "https://www.orthodb.org/?gene=E1BI77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15107:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15107:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10482", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10482", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214988", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214988", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI77", "url": "https://www.uniprot.org/uniprotkb/E1BI77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI77-1", "url": "https://www.uniprot.org/uniprotkb/E1BI77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTRDHAGNRGPVEAKGPSPHLEHRGPRARATGAMESFTESLNRLKEVHENEVMGLQNKLMELNSERCRDAQRVEELCAKNHQLREQQKALKENLRALENRLRAGLCDRCMVTQELARKKQQEFESSLLQNLQHVFLLTTELTRLQEENDALKEEVKRLQGPGPKPQLREGISDPPSPLLLPSLGARKAVTEKPLGGHEETEDGRAERPGVYGTSPMAKISPSPNLHEARTPDMVRNPQRISNQLHGTIAVVRPGSRACSADQGSTNGTPPLLPTRNSPPSPPGEHSLPLDSFLQASRPSARTCESLKHSLQADRLCLLNRHLTLHLGSPPAPATAPSGPQSQGLKAGEAEAWEEPSGLLGLPGALVGVRNPRLEGALHMLLAQQLRAQGRVGSARLRGPWGPRGTPPSPPADSDSEGPEGEAARETLSRRRHPQPAGPGSPQGKEGTATQDYVPDKPLDLSERGRCRASTPKPANQSGSLSPPQVPTPSPEPPQGVGPPAQCGAQRLSNGTQEAKEPEAEEHPSSPDPPYSAPGPHLSLPSPSGPGEEDRGRPRLPPYPPRPGGDSHPELSKVHGQQLESDELDEPDTSDSEMVLSTRAEATESSPGEGPGCVCDKECGRGPQKRKRASDSWSKASKKPT", "length": 641, "header": "tr|E1BI77-1|E1BI77_BOVIN Isoform 1 of RBBP8 N-terminal like OS=Bos taurus OX=9913 GN=RBBP8NL PE=4 SV=3 CANONICAL=E1BI77-1" }, "isoforms": [ { "isoform_ac": "E1BI77-1", "url": "https://www.uniprot.org/uniprotkb/E1BI77/entry#E1BI77-1", "sequence": { "sequence": "MRTRDHAGNRGPVEAKGPSPHLEHRGPRARATGAMESFTESLNRLKEVHENEVMGLQNKLMELNSERCRDAQRVEELCAKNHQLREQQKALKENLRALENRLRAGLCDRCMVTQELARKKQQEFESSLLQNLQHVFLLTTELTRLQEENDALKEEVKRLQGPGPKPQLREGISDPPSPLLLPSLGARKAVTEKPLGGHEETEDGRAERPGVYGTSPMAKISPSPNLHEARTPDMVRNPQRISNQLHGTIAVVRPGSRACSADQGSTNGTPPLLPTRNSPPSPPGEHSLPLDSFLQASRPSARTCESLKHSLQADRLCLLNRHLTLHLGSPPAPATAPSGPQSQGLKAGEAEAWEEPSGLLGLPGALVGVRNPRLEGALHMLLAQQLRAQGRVGSARLRGPWGPRGTPPSPPADSDSEGPEGEAARETLSRRRHPQPAGPGSPQGKEGTATQDYVPDKPLDLSERGRCRASTPKPANQSGSLSPPQVPTPSPEPPQGVGPPAQCGAQRLSNGTQEAKEPEAEEHPSSPDPPYSAPGPHLSLPSPSGPGEEDRGRPRLPPYPPRPGGDSHPELSKVHGQQLESDELDEPDTSDSEMVLSTRAEATESSPGEGPGCVCDKECGRGPQKRKRASDSWSKASKKPT", "length": 641, "header": "tr|E1BI77-1|E1BI77_BOVIN Isoform 1 of RBBP8 N-terminal like OS=Bos taurus OX=9913 GN=RBBP8NL PE=4 SV=3 CANONICAL=E1BI77-1" }, "locus": { "chromosome": "13", "start_pos": 54851725, "end_pos": 54837700, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004108.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004108.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004108.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004108.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 488, "start_aa": "Thr", "end_pos": 488, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr488", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTF0-1", "protein_name": "RBBP8 N-terminal like", "gene_name": "Rbbp8nl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSFMESLNRLKEAHEKEVLGLQNKLLELNSERCRDAQRVEELFAKNHQLREQQKALKENLRVLENRLRAGLCDRCMVTQELARKKQLELESAHLQSLQHLCVLTNEMNVLREENKILKEEVKRLRNLGDKTTPQTWEGTSEPPSPLPLPSPSNRKGATENPPGGSEEAEEEQGTDKLSSHKTSPVARVSPATNLLEPRTLDMTPQCISNQLHSTVAVVRPGSRACPPDSDTANGTPPPPSMRSSPSSPTYEHGLPVDSFLRAARPSAIAYETLKHSLQTDRLCLLNRHLSLHLQSPHSSLLTPAAAPNSPLPRGLKAREAEAWEEPSALVGVQDPRLEGALHLLLVQQHLRARARASTARLRVPSAPKEMPSSPPADSDSESSDSEAPKPVLSTEAQPDGWHPPPIGQSSSQRKETLVATQDSPPDKPLDLSDRGRCRDTSKSTGQPLPLSPTPDPQLPALSRPLILSSHTLSNGSTETRAQESEEYSTPKDTSQTLSGIHVGLTSPRRTAEEPGGRPRPGPHLQRPDADGTTAQRPELEQLGESDASDTKAGLISESSIETSIAGEGQHAEDLRRGQQQKRKRASDLQDKAPKKPSQGKRKPKEPLTPADGPRSPRDTEDYSLSPINSCRES", "length": 634 }, "evidence": [ { "id": "E1BI77", "url": "https://omabrowser.org/oma/group/E1BI77/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZR01-1", "protein_name": "RBBP8 N-terminal like", "gene_name": "RBBP8NL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTTESFAEFLNKLKEIHEREVQGLQTKLTELTTEKCRDAQRIEELFAKNHQLREQQKVLKENVKVLENRLRAGLCDRCMVTQELAKKKQNEYENSHFQSLQHIFILTNEMSRLKEENKALKEELKRLQSPEDRTKYPGVISREHSSTPSSPLPLLSPTSRNTSIERVALGAAEDSQHGVPGLELGEEKATGQRSSPSSRVSPSTVLQEASLAEMASQRIANQLHGTIALVRHSLEKSPSGAAVSPPARKTLLPPEQERSPSLEPYLTTTKPISPKIVPSYESLKLTARKEQLCLLNKHLALHQLGLTSGCAPSDGDSSFHRQLLRATDGDGRTRPRDDWDDRAALLKLPAAVVYVRDQHLEGKLHLLKHHERLQHLEQQRSHRVRVDGEPKAVSKERPLSPCLSITVGCKEERMEDAEDGKVERELWLSRDGSEHRGKAESLRDYGVDAPLDLSDTGRGKGMGWIKHQEANSPRLSPGDSPMHGPCRRHGMERDSSQPHSCWHDAAQTQLTGQPGAIKEEEEEEEEETAVLALSRVHPINKSTASNTETPPEPRVRLVASAQKEEPGKELQASLTSEKSNAKDDDDDESAKQESDEADTTDSEVASPYERDVLQEAQSEGKYFCTKDRAHVLQKKRRRGQDSWTKGSKKAVRGRKKVKVEQCSLEMTEEAESCLASHHDPSEDS", "length": 684 }, "evidence": [ { "id": "E1BI77", "url": "https://omabrowser.org/oma/group/E1BI77/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2ABX0-1", "protein_name": "RBBP8 N-terminal like", "gene_name": "Rbbp8nl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSFMESLNRLKEAHEKEVLGLQNKLLELNSERCRDAQRVEELFAKNHQLREQQKALKENLRVLENRLRAGLCDRCMVTQELARKKQLELENAHLQSLQHLCILTNEMNGLREENKILKEEVKRLRSLGDKTAPQAWEGTSEPPSPLPLPSPSSWKGTTENPPGAPEEAEEEQSGTDKISSHKTSPVSRVSPAANLPEPRALDMTPQCISNQLHSTVAVVRPGSRACPPDSGSADGTPPPSTRSTPPSPTYEHGLPVDSFLRASRPSAIAYETLKHSLQTDRLCLLNRQLSLRLQSPHSSPLASAVAPHSPLPRGLKAREAEAWEEPGALVGMQDPRLEGALHLLLVQQHLRARARASTARLQVPSAPEEMPSSPPAGSDSEGSDSEAPKPALSTEAQPDGWHPQTTGQGSSQRKETHVATQDCPPDKPLDLSDRGRCRDISKSTGQPLPLSPKIVYTPSPQLPTLSRPLVPSSHTLSNVSTETRAQESEEYSTPKDTSHPLPGVCMGLTSPGRTAEEAGGRPQPGPHLQRPDTGGTTEPKKVRAQRLALEQLEESDTSDTKAGLISEASAEPSMPGVGHAEDHQQSQQQKRKRASDLQDKGTYLREGKAGPGM", "length": 614 }, "evidence": [ { "id": "E1BI77", "url": "https://omabrowser.org/oma/group/E1BI77/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NC74-1", "protein_name": "RBBP8 N-terminal-like protein", "gene_name": "RBBP8NL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRGLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSPWEET", "length": 664 }, "evidence": [ { "id": "E1BI77", "url": "https://omabrowser.org/oma/group/E1BI77/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI77-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 641, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI77-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI77" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI77" }, { "id": "PF10482", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10482" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA endonuclease Ctp1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 157, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 488 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 267, "end_pos": 269 }, { "start_pos": 476, "end_pos": 478 }, { "start_pos": 510, "end_pos": 512 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI78-1", "uniprot_ac": "E1BI78", "uniprot_id": "E1BI78_BOVIN", "mass": { "chemical_mass": 42692.0, "monoisotopic_mass": 42692.0 }, "refseq": {}, "gene_names": [ { "name": "YBEY", "type": "recommended", "evidence": [ { "id": "E1BI78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ] } ], "protein_names": [ { "name": "YbeY metalloendoribonuclease", "type": "synonym", "evidence": [ { "id": "E1BI78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI78/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YBEY", "url": "https://www.uniprot.org/uniprotkb/E1BI78", "locus": { "chromosome": "1", "start_pos": 145977560, "end_pos": 145972641, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003161", "url": "https://www.ensembl.org/id/ENSBTAG00000003161" } ] } } ], "crossref": [ { "id": "E1BI78", "url": "https://alphafold.ebi.ac.uk/entry/E1BI78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003161", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003161", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BI78", "url": "https://www.orthodb.org/?gene=E1BI78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46986", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46986", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46986:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46986:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI78-1", "url": "https://www.uniprot.org/uniprotkb/E1BI78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHPRAPGRAPSVFPQPRSISNTAAAAAKRAASALQGLAPCSPSSSGTRPPTVLRAREARRARGRLGQCCPRPANTKHRGPTSGRSRAAQHRPGPAARGFRSPAGRWRSGFRGAASTPPSARFCSVSASSPKWGGARWACRAPLHRWALPSRPFSSVCHRPSGASHSTVCPGPPCCVFLSVKRTFHDSFQRIPPNGVTCPCVRVRCYRTSEGFTIHRPEVEMSLALRNLQRAVPLRRALLRQRLQAVRGALGVRAFDLGVVCVDNRKIQQMNRIYREQDTPTDVLSFPFHENLKAGEIPQPDFPDDYNLGDIFLGVEFIFQQCKEDEDYYDILTVTATHGLCHLLGFTHSTEAEWQKMYQKEKQVLQELNKHMGTRLQPLSRGLF", "length": 385, "header": "tr|E1BI78-1|E1BI78_BOVIN Isoform 1 of YbeY metalloendoribonuclease OS=Bos taurus OX=9913 GN=YBEY PE=3 SV=3 CANONICAL=E1BI78-1" }, "isoforms": [ { "isoform_ac": "E1BI78-1", "url": "https://www.uniprot.org/uniprotkb/E1BI78/entry#E1BI78-1", "sequence": { "sequence": "MSHPRAPGRAPSVFPQPRSISNTAAAAAKRAASALQGLAPCSPSSSGTRPPTVLRAREARRARGRLGQCCPRPANTKHRGPTSGRSRAAQHRPGPAARGFRSPAGRWRSGFRGAASTPPSARFCSVSASSPKWGGARWACRAPLHRWALPSRPFSSVCHRPSGASHSTVCPGPPCCVFLSVKRTFHDSFQRIPPNGVTCPCVRVRCYRTSEGFTIHRPEVEMSLALRNLQRAVPLRRALLRQRLQAVRGALGVRAFDLGVVCVDNRKIQQMNRIYREQDTPTDVLSFPFHENLKAGEIPQPDFPDDYNLGDIFLGVEFIFQQCKEDEDYYDILTVTATHGLCHLLGFTHSTEAEWQKMYQKEKQVLQELNKHMGTRLQPLSRGLF", "length": 385, "header": "tr|E1BI78-1|E1BI78_BOVIN Isoform 1 of YbeY metalloendoribonuclease OS=Bos taurus OX=9913 GN=YBEY PE=3 SV=3 CANONICAL=E1BI78-1" }, "locus": { "chromosome": "1", "start_pos": 145977380, "end_pos": 145972840, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004104.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004104.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004104.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004104.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 82, "start_aa": "Thr", "end_pos": 82, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "E1BI78", "url": "https://www.uniprot.org/uniprotkb/E1BI78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 385, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI78" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 82 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI87-1", "uniprot_ac": "E1BI87", "uniprot_id": "E1BI87_BOVIN", "mass": { "chemical_mass": 53283.0, "monoisotopic_mass": 53283.0 }, "refseq": { "ac": "NP_001231280", "name": "long palate lung and nasal epithelium protein 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231280" }, "gene_names": [ { "name": "BPIFB5", "type": "recommended", "evidence": [ { "id": "E1BI87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI87" } ] }, { "name": "BPIFB5", "type": "synonym", "evidence": [ { "id": "NP_001231280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231280" } ] }, { "name": "LPLUNC5", "type": "synonym", "evidence": [ { "id": "NP_001231280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231280" } ] } ], "protein_names": [ { "name": "BPI fold containing family B, member 5", "type": "synonym", "evidence": [ { "id": "E1BI87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI87/entry#names_and_taxonomy" } ] }, { "name": "long palate lung and nasal epithelium protein 5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001231280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231280" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI87", "url": "https://www.uniprot.org/uniprotkb/E1BI87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BPIFB5", "url": "https://www.uniprot.org/uniprotkb/E1BI87", "locus": { "chromosome": "13", "start_pos": 62810151, "end_pos": 62791793, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031361", "url": "https://www.ensembl.org/id/ENSBTAG00000031361" } ] } } ], "crossref": [ { "id": "E1BI87", "url": "https://alphafold.ebi.ac.uk/entry/E1BI87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031361", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031361", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525104", "url": "https://www.ncbi.nlm.nih.gov/gene/525104", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525104", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525104", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VFMRISK", "url": "https://omabrowser.org/oma/group/VFMRISK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI87", "url": "https://www.orthodb.org/?gene=E1BI87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46019:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46019:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001231280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI87", "url": "https://www.uniprot.org/uniprotkb/E1BI87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI87-1", "url": "https://www.uniprot.org/uniprotkb/E1BI87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLFWGSLLCWGLLPQVQGEAQHFVFMRISKDQLETDISDLLFKHRVLDRVTRIPVRGDAGEGIAILDHMPFVRKGLSKKSTGLDLPLIRGLLLGQSLSPLGELLQLGGLVIEDSEGPEVTLQVLSDSLLQVTLRSKLYLSLQRILRLRVIKNIRIGARLEQTGNKTHVAFEECHTPPGYLSIEVLEQMNPLLVNEALRLVTDVLDEALPFLLQKIVCPTATTLLNSLLEDLLHITLPPASSGPEDFQYYVTTTEFTEKAILMKVQLVTPCSPGQRVPRPGHLAPKPLPKLAQGSLADLVFSLETYNDILSCLYTSKEIHVNPQDPVAANLNQLLSLSVLEPEPKTSDQSRGNVGLTISIPDPPIVHLDGHTASVIQPGSLVLAGSSNTSPVSVSWKLLSNAVFSSKNRELKLQFTPNSITVILGPYPAGLEKQKECLEAFLFELLNWRVLPHHNNLLREQGIDQARMEPSEDYLPLTVPKE", "length": 482, "header": "tr|E1BI87-1|E1BI87_BOVIN Isoform 1 of BPI fold containing family B, member 5 OS=Bos taurus OX=9913 GN=BPIFB5 PE=3 SV=2 CANONICAL=E1BI87-1" }, "isoforms": [ { "isoform_ac": "E1BI87-1", "url": "https://www.uniprot.org/uniprotkb/E1BI87/entry#E1BI87-1", "sequence": { "sequence": "MLLFWGSLLCWGLLPQVQGEAQHFVFMRISKDQLETDISDLLFKHRVLDRVTRIPVRGDAGEGIAILDHMPFVRKGLSKKSTGLDLPLIRGLLLGQSLSPLGELLQLGGLVIEDSEGPEVTLQVLSDSLLQVTLRSKLYLSLQRILRLRVIKNIRIGARLEQTGNKTHVAFEECHTPPGYLSIEVLEQMNPLLVNEALRLVTDVLDEALPFLLQKIVCPTATTLLNSLLEDLLHITLPPASSGPEDFQYYVTTTEFTEKAILMKVQLVTPCSPGQRVPRPGHLAPKPLPKLAQGSLADLVFSLETYNDILSCLYTSKEIHVNPQDPVAANLNQLLSLSVLEPEPKTSDQSRGNVGLTISIPDPPIVHLDGHTASVIQPGSLVLAGSSNTSPVSVSWKLLSNAVFSSKNRELKLQFTPNSITVILGPYPAGLEKQKECLEAFLFELLNWRVLPHHNNLLREQGIDQARMEPSEDYLPLTVPKE", "length": 482, "header": "tr|E1BI87-1|E1BI87_BOVIN Isoform 1 of BPI fold containing family B, member 5 OS=Bos taurus OX=9913 GN=BPIFB5 PE=3 SV=2 CANONICAL=E1BI87-1" }, "locus": { "chromosome": "13", "start_pos": 62810148, "end_pos": 62791793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044433.3", "url": "https://www.ensembl.org/id/ENSBTAT00000044433.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041929.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041929.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525104", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525104", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTZ5-1", "protein_name": "BPI fold containing family B, member 5", "gene_name": "Bpifb5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLLLCALLFCWGMLPQARGMTHGPLFLRINKTQLETDISDLLLEYQVLKGVIRMTVTGSPSEGVSVLDRLPFVRKELVKKKSGLDLSLVGDLLSGKTIPELKKLLETAGLVIEDAKGPEVTLEILSDSLLQITLRCKLYLSLLESLWLEAIKNIRIGVRLEQIGNKTRVAFEDCHTPPGSLSIEILKRSDTLLPNQLLELVADTLDGSLPFFLQKIVCPVTTNLINFLLEDMLHIILPPVISDPNDFQYYLTTTEFTEGAILMRVELVTPCGPHQRPPRSEHVVLPPLPGLSQNSMADFAFWLEIYNDILACLYTSQEIFIEPQDSSEVGLWQLLSLRSSQSQPGAYNLTRGSLGLIISAPQPPTVHLDGCRTTVTQQGLLTLQGTNNASSGAVAWQLLCKGVFSSGSQKQQLQVTPHGAVVTLGSYPTIMEKQGEYLKALLLAVLKRWFLPHHNKWLREHSLPLANIKGISFSHAQMDFSEDYILLTVPE", "length": 492 }, "evidence": [ { "id": "E1BI87", "url": "https://omabrowser.org/oma/group/E1BI87/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S503-1", "protein_name": "Long palate lung and nasal epithelium protein 5", "gene_name": "BPIFB5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLLLGSLLCGGLLPQAQGKAQHLVFIRISKNQLETDISDMFLKHHVLDRLAKIPVMGATSEGATILDHLPFVRKGLSKKSSGLDLSLVTDLLLGQSLPPLGKLLQAGGLVIEDAKGPEVTLQILSDSLLQVTLRNKLYLSLQRILRFKVIKNIRIGVRLEQIGNKTNVAFEECHTPPGFLNIEVLEHMGLLLVNEALKLATDVLDKALPFLLQKIVCPLATTLLNLLLEDLLHITLPPTISDPEDFQYHVTTTEFTEEAILMKVQLVTPCGSGKRAPKPDYLDPNPLPTLAQDSMADLAFPLETYNDILSCLYSSKEIHVNLWDPTAADLIQLLLPRELELGPKTSHQPRRSVGLTISTPNPPTVHLGGHTAAVIQQGSLVLLGPGNTSSVSVSWKLLSKAVFSSKNRELKLQFTPNSIAVTLGPYPPGLAKQEERLEASVLELLRRRFLPHHNNLLREQGLLLPNIKGISFDQAQMEPSQNHLLLTVPKE", "length": 492 }, "evidence": [ { "id": "E1BI87", "url": "https://omabrowser.org/oma/group/E1BI87/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1BI87", "url": "https://www.uniprot.org/uniprotkb/E1BI87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI87-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 482, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI87-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI87" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI87" }, { "id": "PF01273", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01273" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipid-binding serum glycoprotein N-terminal", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 228, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 388, "end_pos": 390 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI89-1", "uniprot_ac": "E1BI89", "uniprot_id": "E1BI89_BOVIN", "mass": { "chemical_mass": 66346.0, "monoisotopic_mass": 66346.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Vomeromodulin-like", "type": "recommended", "evidence": [ { "id": "E1BI89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI89/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI89", "url": "https://www.uniprot.org/uniprotkb/E1BI89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BI89", "locus": {} } ], "crossref": [ { "id": "E1BI89", "url": "https://alphafold.ebi.ac.uk/entry/E1BI89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031354", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031354", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR034433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DCKNSTG", "url": "https://omabrowser.org/oma/group/DCKNSTG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR40142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR40142:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40142:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1BI89", "url": "https://www.uniprot.org/uniprotkb/E1BI89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI89-1", "url": "https://www.uniprot.org/uniprotkb/E1BI89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKDFSERHWSIKMGWRFSSDRSEAEAGVRHLLKTCAHQHQPIGTGRGIGHKMLTLWALAIMLAIQAGALDLSTSPSQVGAPPDKITSRLPVHFPISVPDPQVPRISSIRKGSLPPRRAAGTSGARCSPVAKYLVSSSKLNDYLNATLTPKIENMLKCEEINLAGVLGEVISTVSNSGLLSVLDLTSSLDILGGGGLGGILGRGSSNKSPKHPQSLLSEATGAVSDLGQGALGSLPLLGGENAVKELVDSTGLLTGDKLKETTEGILNSVVPKDINSALTGLLGNIDLEDLLLGLEVEKVTVENMTSTMTGNGILVHAVTTAFIGGNGLAGPVVSILGFQVHADVTLEIGISSNNTQCVSLLVQEKNIEVKNVNLQIAEVVTGVLPLPLPLDDTISQLLTVTMNENIEGSKSCGIELSDINECKNSTGLFNYQVKSPRTSAEGLSILYCAYFNQNKSPVPGSHLPPDPKNVNTAVILSQMMLREIVTKSAKESSVKINNLEAAITKIVYHHLPNNKINAAYGVTIVKDGENIATGQTEVTISHASEISNNKIKTTIKTDSAKHSVIPPEAEEEERDVLREVLKKLLFAVTRNVNQWNIPLGVIPNSINSAKLQVLKSNDFQATN", "length": 624, "header": "tr|E1BI89-1|E1BI89_BOVIN Isoform 1 of Vomeromodulin-like OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BI89-1" }, "isoforms": [ { "isoform_ac": "E1BI89-1", "url": "https://www.uniprot.org/uniprotkb/E1BI89/entry#E1BI89-1", "sequence": { "sequence": "MSKDFSERHWSIKMGWRFSSDRSEAEAGVRHLLKTCAHQHQPIGTGRGIGHKMLTLWALAIMLAIQAGALDLSTSPSQVGAPPDKITSRLPVHFPISVPDPQVPRISSIRKGSLPPRRAAGTSGARCSPVAKYLVSSSKLNDYLNATLTPKIENMLKCEEINLAGVLGEVISTVSNSGLLSVLDLTSSLDILGGGGLGGILGRGSSNKSPKHPQSLLSEATGAVSDLGQGALGSLPLLGGENAVKELVDSTGLLTGDKLKETTEGILNSVVPKDINSALTGLLGNIDLEDLLLGLEVEKVTVENMTSTMTGNGILVHAVTTAFIGGNGLAGPVVSILGFQVHADVTLEIGISSNNTQCVSLLVQEKNIEVKNVNLQIAEVVTGVLPLPLPLDDTISQLLTVTMNENIEGSKSCGIELSDINECKNSTGLFNYQVKSPRTSAEGLSILYCAYFNQNKSPVPGSHLPPDPKNVNTAVILSQMMLREIVTKSAKESSVKINNLEAAITKIVYHHLPNNKINAAYGVTIVKDGENIATGQTEVTISHASEISNNKIKTTIKTDSAKHSVIPPEAEEEERDVLREVLKKLLFAVTRNVNQWNIPLGVIPNSINSAKLQVLKSNDFQATN", "length": 624, "header": "tr|E1BI89-1|E1BI89_BOVIN Isoform 1 of Vomeromodulin-like OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BI89-1" }, "locus": { "chromosome": "13", "start_pos": 62843553, "end_pos": 62825044, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044427.3", "url": "https://www.ensembl.org/id/ENSBTAT00000044427.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041923.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041923.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q80XI7-1", "protein_name": "Vomeromodulin", "gene_name": "Bpifb9a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWVLQALAIMLSIQAGTLDLVETPPVVGNLPVAMPVPLNLPVGGLSPPVLKGPVNHQMLPPKRPVPPPKGGKCAPAARYFLSSDKLHDYLMSTLPPQIEDMVKCDEVNLEGMLADVLNTVESSDLLSLLDGISLLKGGEGGGLGIGGLLGNEGNGDSSKPSSGSKATGGLGQLIPGGIPGTEALGGLLNLGGDKSSGKGLLNGDGLSKIKKPLEDAVENVSGIKDAIQEKVNEVVPDGVKEPLNDVLKMDIKDTLLELKVGQVTLDDMEINMEANGMQVLSMLTATIDGKGVLGPVISLLQFEAKMDVMTTIAVASNNTQCVNLDAQDTHMHVKEMKIQLVETVTGKVPLPVPLPLDQIIPAIVTAKINENLEKSNSCAIVLNDFNNCKNNTGLFSYQVNTARISPKGLVILYCAKANIGNKTVPVPGGRLPPDPKNASIAVTISSTTLKTLVKEVAKNSSVQMDGLEAQITHIAFASQENNTLRVVYKVDITKNGEHFATGETKLFISHGSKISNSTLIPDVKLIRSEHSVVPPEAKEEVEGILSEVGKVAWSNFNETYKKMNIPVGVSSHTLKNSDVKLMKSIDLQAAS", "length": 591 }, "evidence": [ { "id": "E1BI89", "url": "https://omabrowser.org/oma/group/E1BI89/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "E1BI89", "url": "https://www.uniprot.org/uniprotkb/E1BI89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI89-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 624, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI89-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI89" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 304, "end_pos": 306 }, { "start_pos": 354, "end_pos": 356 }, { "start_pos": 425, "end_pos": 427 }, { "start_pos": 455, "end_pos": 457 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI95-1", "uniprot_ac": "E1BI95", "uniprot_id": "E1BI95_BOVIN", "mass": { "chemical_mass": 61270.0, "monoisotopic_mass": 61270.0 }, "refseq": { "ac": "XP_002685069", "name": "protein ANKUB1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685069" }, "gene_names": [ { "name": "ANKUB1", "type": "recommended", "evidence": [ { "id": "E1BI95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI95" } ] }, { "name": "ANKUB1", "type": "synonym", "evidence": [ { "id": "XP_002685069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685069" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and ubiquitin domain containing 1", "type": "synonym", "evidence": [ { "id": "E1BI95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI95/entry#names_and_taxonomy" } ] }, { "name": "protein ANKUB1", "type": "synonym", "evidence": [ { "id": "XP_002685069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685069" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI95", "url": "https://www.uniprot.org/uniprotkb/E1BI95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKUB1", "url": "https://www.uniprot.org/uniprotkb/E1BI95", "locus": { "chromosome": "1", "start_pos": 118396058, "end_pos": 118367002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031346", "url": "https://www.ensembl.org/id/ENSBTAG00000031346" } ] } } ], "crossref": [ { "id": "E1BI95", "url": "https://alphafold.ebi.ac.uk/entry/E1BI95", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031346", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031346", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17050", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17050", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785299", "url": "https://www.ncbi.nlm.nih.gov/gene/785299", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785299", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785299", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGGLTAC", "url": "https://omabrowser.org/oma/group/QGGLTAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI95", "url": "https://www.orthodb.org/?gene=E1BI95", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46885", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46885", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46885:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46885:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685069", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685069", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI95", "url": "https://www.uniprot.org/uniprotkb/E1BI95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI95-1", "url": "https://www.uniprot.org/uniprotkb/E1BI95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRIFIAFEGSFEPFDVSTDKTVEAVKLMIKDYFHIPLSEDEQGRRYLELTYAGAALKDSWSLVDVGISFCSTLKCFVKEEDKPTLCVFNAVTQETMAIREDISLLGKKVSDLRTLIALRCGFPVSVFCLRTPEGLEMYDCNLLRDYQTELGTTLRLDVWDGWKEFLMGCLLGQKLQVQRYLSNEGPVLKYQKRVALYIAAFYGYIELTEWALKQGVRPHETVGVHPYRAWCQEALHTDVSKCPIHAAAEAGQLLILKAFVNCSVLCLDCKNAAGQTPLTIACKHKHKDCVLYLLSKMWSTVSFLKISVSMRIYIKIKQWVLRAQSHNLNKGQLCGARVLGAKVGDVVMVDGFTKPKMTSKSWQKAMDKDSQGGIESKLPPLREQTVSRKLACPLAVAQQDTREEIVRFPPLVDANTFSELQKRQQSQKKTTATTRKKEKLIKNTYMPQVPLPPISRVGYSHPSFYYATPSADFLLRSSFASFSEHSGRTPRQNAIYCLAVASAFKEKRWLQQLGIARVLAKKSISNLTTQGGLTACENPPEIVL", "length": 544, "header": "tr|E1BI95-1|E1BI95_BOVIN Isoform 1 of Ankyrin repeat and ubiquitin domain containing 1 OS=Bos taurus OX=9913 GN=ANKUB1 PE=4 SV=3 CANONICAL=E1BI95-1" }, "isoforms": [ { "isoform_ac": "E1BI95-1", "url": "https://www.uniprot.org/uniprotkb/E1BI95/entry#E1BI95-1", "sequence": { "sequence": "MRIFIAFEGSFEPFDVSTDKTVEAVKLMIKDYFHIPLSEDEQGRRYLELTYAGAALKDSWSLVDVGISFCSTLKCFVKEEDKPTLCVFNAVTQETMAIREDISLLGKKVSDLRTLIALRCGFPVSVFCLRTPEGLEMYDCNLLRDYQTELGTTLRLDVWDGWKEFLMGCLLGQKLQVQRYLSNEGPVLKYQKRVALYIAAFYGYIELTEWALKQGVRPHETVGVHPYRAWCQEALHTDVSKCPIHAAAEAGQLLILKAFVNCSVLCLDCKNAAGQTPLTIACKHKHKDCVLYLLSKMWSTVSFLKISVSMRIYIKIKQWVLRAQSHNLNKGQLCGARVLGAKVGDVVMVDGFTKPKMTSKSWQKAMDKDSQGGIESKLPPLREQTVSRKLACPLAVAQQDTREEIVRFPPLVDANTFSELQKRQQSQKKTTATTRKKEKLIKNTYMPQVPLPPISRVGYSHPSFYYATPSADFLLRSSFASFSEHSGRTPRQNAIYCLAVASAFKEKRWLQQLGIARVLAKKSISNLTTQGGLTACENPPEIVL", "length": 544, "header": "tr|E1BI95-1|E1BI95_BOVIN Isoform 1 of Ankyrin repeat and ubiquitin domain containing 1 OS=Bos taurus OX=9913 GN=ANKUB1 PE=4 SV=3 CANONICAL=E1BI95-1" }, "locus": { "chromosome": "1", "start_pos": 118396055, "end_pos": 118367157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044418.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044418.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041916.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041916.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 468, "start_aa": "Thr", "end_pos": 468, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr468", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:785299", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785299", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GKN0-1", "protein_name": "Ankyrin repeat and ubiquitin domain containing 1", "gene_name": "Ankub1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRIFIAFEGSFEAFDVAAHTSVGAIKQMVKDYFHIPLSEDKQGRWYLELTYAGAALKNNWSLSDVGISFCSTLKCFVKKEDKPTLYVFNAVTQETMAIKENMSILDRKVSDLRMLVTLSCGFPVSVYCLRTPAGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKPKVQRYLSKEGPVLKYQKRVALYIAAFHGHTELTEWALKQGAQPHEAVGVHPCRAWCHEALHTDVSNCPIHAAAEAGQLLILKAFVNFSVLCLECKNAAGQSPLAIASKHQHKDCVLYLLSKIWSTVSFLKLSVPMRIYIKIKQWILRAQTRRCHKSQPSRARVSGAKVGDTVMVDGFTKPKMTSKSWYKAEDKSWHTAQSKLPPCKQQPSRKPIGSLPMSQHDTKKQIFTFPSLVDAKNFSEVQSYQQENQKKIAAPARKEKNIKNPYLPQVPLPPVSRVHYAHPQFYCTPPSGDCLLRSLFKSFSEHSGRTPRENAIYCLAVASAFKEKRWLQQLEIARVLAKRSISNLTVKGGPAKCENYPESVL", "length": 542 }, "evidence": [ { "id": "E1BI95", "url": "https://omabrowser.org/oma/group/E1BI95/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NFN9-2", "protein_name": "Protein ANKUB1", "gene_name": "ANKUB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSWSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSKMWSTVSFPKISVPMRIYIKIKQWILRAQSHSLHKSQFCGARVFGAKVGDTVMVDGFTKPKMTSKSWHKAGNSDSQSIVLKLPSLSKQTASSKPVNPLAISQPDTRKQALKFHPLVNASSFSELQKHQQQNQKKITATARKKEKLIKNTYLPQVPLPPVSRVGYSHPSFFYATPSADFLLKSSFSSFLEHSGKTPWENAIYCLAVAR", "length": 502 }, "evidence": [ { "id": "E1BI95", "url": "https://omabrowser.org/oma/group/E1BI95/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3UUE9-1", "protein_name": "Protein ANKUB1", "gene_name": "Ankub1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIFIAFEGSFEAFDVEAHTSVGAIKQMIKDYFHIPLSEDKQGRWYLELMYAGAALRNSWSLSDVGISFCSTLKCFVKKEDKPTLYVFNAVTQEMMPIMENMSLLDKKVSDLRMLVTLRCGFPVSVYCLRTPTGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKPKVQHYLSKEGPVLKYGS", "length": 192 }, "evidence": [ { "id": "E1BI95", "url": "https://omabrowser.org/oma/group/E1BI95/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI95-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 544, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI95-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI95" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 468 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 526, "end_pos": 528 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BI98-1", "uniprot_ac": "E1BI98", "uniprot_id": "E1BI98_BOVIN", "mass": { "chemical_mass": 108671.0, "monoisotopic_mass": 108671.0 }, "refseq": { "ac": "NP_001137337", "name": "collagen alpha-1(VI) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" }, "gene_names": [ { "name": "COL6A1", "type": "recommended", "evidence": [ { "id": "E1BI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ] }, { "name": "COL6A1", "type": "synonym", "evidence": [ { "id": "NP_001137337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(VI) chain", "type": "recommended", "evidence": [ { "id": "E1BI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI98/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-1(VI) chain precursor", "type": "synonym", "evidence": [ { "id": "NP_001137337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" } ] }, { "name": "collagen, type VI, alpha 1", "type": "synonym", "evidence": [ { "id": "NP_001137337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" } ] } ], "function": [ { "annotation": "Collagen VI acts as a cell-binding protein.", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98#function" }, { "database": "UniProtKB", "id": "ARBA00043858", "url": "https://www.uniprot.org/uniprotkb/ARBA00043858#function" } ] }, { "annotation": "The distribution of type II and VI collagen was immunocytochemically investigated in bovine articular and nasal cartilage.", "evidence": [ { "database": "RefSeq", "id": "NP_001137337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" }, { "database": "PubMed", "id": "20213143", "url": "https://glygen.org/publication/PubMed/20213143" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL6A1", "url": "https://www.uniprot.org/uniprotkb/E1BI98", "locus": { "chromosome": "1", "start_pos": 145687976, "end_pos": 145668730, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011802", "url": "https://www.ensembl.org/id/ENSBTAG00000011802" } ] } } ], "crossref": [ { "id": "E1BI98", "url": "https://alphafold.ebi.ac.uk/entry/E1BI98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011802", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011802", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01480", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01480", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511422", "url": "https://www.ncbi.nlm.nih.gov/gene/511422", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9HAN", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9HAN&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511422", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511422", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEKKCPD", "url": "https://omabrowser.org/oma/group/QEKKCPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BI98", "url": "https://www.orthodb.org/?gene=E1BI98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009han", "url": "https://www.rcsb.org/structure/pdb_00009han", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9HAN", "url": "https://www.rcsb.org/structure/9HAN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-186797", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186797", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2022090", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001137337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI98-1", "url": "https://www.uniprot.org/uniprotkb/E1BI98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLPRALLPLLLQACWASAQDDPVASRAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLNDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKSSVDAVKYFGKGTYTDCAIKKGLEELLVGGSHLKENKYLVVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEVISQTIDTITDMIKNNVEQVCCSFECQPARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGMDGVDGMKGETGFPGLPGCKGSPGFDGIQGPPGPKGDPGAFGLKGQKGEPGADGEPGRPGSTGPPGDEGEPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGARGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGTEGPKGAPGPAGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGSRGPPGINGTKGYPGLKGDEGEAGDPGEDNNDIAARGAKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECKCGPIDILFVLDSSESIGLQNFEIAKDFIVKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDLRDPNIRNAQDLKEAIKKLQWMGGGTFTGEALQYTRSRLLPPTPNNRIALVITDGRSDTQRDTTPLSVLCGPDIQVVSVGIKDVFGLAAGSDQLNVISCQGLAPQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYSCPITFSSPADITILLDGSASVGSHNFDITKRFAKRLAERFLTASRTDPGQDVRVAVVQYSGTGQQRPERAALQFLQNYTVLANTVDSMDFFNDATDVMDALGYVTRFYREASSNAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGVEIFAVVVGRQVNEPHVRVLVTGKAAEYDVVFGERHLFRVPSYQALLRGVFYQTVSRKVALD", "length": 1027, "header": "tr|E1BI98-1|E1BI98_BOVIN Isoform 1 of Collagen alpha-1(VI) chain OS=Bos taurus OX=9913 GN=COL6A1 PE=1 SV=1 CANONICAL=E1BI98-1" }, "isoforms": [ { "isoform_ac": "E1BI98-1", "url": "https://www.uniprot.org/uniprotkb/E1BI98/entry#E1BI98-1", "sequence": { "sequence": "MRLPRALLPLLLQACWASAQDDPVASRAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLNDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKSSVDAVKYFGKGTYTDCAIKKGLEELLVGGSHLKENKYLVVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEVISQTIDTITDMIKNNVEQVCCSFECQPARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGMDGVDGMKGETGFPGLPGCKGSPGFDGIQGPPGPKGDPGAFGLKGQKGEPGADGEPGRPGSTGPPGDEGEPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGARGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGTEGPKGAPGPAGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGSRGPPGINGTKGYPGLKGDEGEAGDPGEDNNDIAARGAKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECKCGPIDILFVLDSSESIGLQNFEIAKDFIVKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDLRDPNIRNAQDLKEAIKKLQWMGGGTFTGEALQYTRSRLLPPTPNNRIALVITDGRSDTQRDTTPLSVLCGPDIQVVSVGIKDVFGLAAGSDQLNVISCQGLAPQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYSCPITFSSPADITILLDGSASVGSHNFDITKRFAKRLAERFLTASRTDPGQDVRVAVVQYSGTGQQRPERAALQFLQNYTVLANTVDSMDFFNDATDVMDALGYVTRFYREASSNAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGVEIFAVVVGRQVNEPHVRVLVTGKAAEYDVVFGERHLFRVPSYQALLRGVFYQTVSRKVALD", "length": 1027, "header": "tr|E1BI98-1|E1BI98_BOVIN Isoform 1 of Collagen alpha-1(VI) chain OS=Bos taurus OX=9913 GN=COL6A1 PE=1 SV=1 CANONICAL=E1BI98-1" }, "locus": { "chromosome": "1", "start_pos": 145687207, "end_pos": 145668949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015668.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015668.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015668.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015668.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 435, "start_aa": "Thr", "end_pos": 435, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr435", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 950, "start_aa": "Thr", "end_pos": 950, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr950", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens.", "journal": "Journal of molecular histology", "date": "2010-02", "authors": "Jansen I D C, Hollander A P, Buttle D J, Everts V", "evidence": [ { "database": "RefSeq", "id": "NP_001137337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137337" } ], "reference": [ { "type": "PubMed", "id": "20213143", "url": "https://glygen.org/publication/PubMed/20213143" } ] }, { "title": "Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations.", "journal": "Nat. Commun.", "date": "2025", "authors": "Dajani R., Baldock C., Roseman A.M., Becker M.H., Godwin A.R.F., Snee M.", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "reference": [ { "type": "PubMed", "id": "40813585", "url": "https://glygen.org/publication/PubMed/40813585" } ] } ], "pathway": [ { "id": "bta:511422", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511422", "resource": "KEGG Pathway" }, { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-186797", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186797", "resource": "Reactome", "description": "Signaling by PDGF" }, { "id": "R-BTA-2022090", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YNN9-1", "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "COL6A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQQAAFLQSPLGSAQGSEPPGRSWGTAESFGRSARVQGAQKDSEEKRRLASESARTALVPPSIPAAESPPRPLPPARSSFPGSQALKPPPDPDPASPSFLPSLQLDVNLSPATWGCTTPSWRCCFFWGVPGLSRLKSTPVSSGLRLCRGPSGKRCCATLLCLPSDCPVDLFFVLDTSESVALRVKPFGDLVAQVKDFTNRFIDKLTERYFRCDRFLAWNAGALHYSDSVVIIKDLTAMPSGRAELKNSVSAINYIGKGTHTDCAIKQGIERLLLGGSHLKENKYLIVVTDGHPLEGYKEPCGGLDDAANEAKHLGIKVFSVAISPHHLDQRLNIIATDHAYRRNFTATSLKPTRDLDVEETINNIIEMIKDNMEQSCCSFECHPPRGPPGPPGDPGHEGERGKPGLPGQKGDAGDPGRPGDMGPVGYQGMKGDKGSRGEKGSRGAKGAKGEKGKRGIDGIDGMKGEAGYPGLPGCKGSPGFDGTQGPPGPKGDPGAYGPKGGKGEPGEDGKPGRQGIPGSPGEKGAPGNRGEPGPLGETGDEGSPGADGPPGERGSNGERGPPGSPGDRGPRGDLGEPGPPGDQGREGPLGPPGDQGEPGPPGPKGYRGDDGPRGNEGPKGSPGAPGLPGDPGLMGERGEDGPPGNGTIGFPGAPGQQGDRGDPGINGTKGYVGPKGDEGEAGDPGNDNPTAGPSGIKGAKGHRGPEGRPGPPGPVGPPGPDECEILDIIMKMCSCCECTCGPVDLLFVLDSSESIGLQNFQIAKDFIIKVIDRLSKDERVKFEPGESRVGVVQYSHNNTQELVAMGDANIDNIGALKQAVKNLKWIAGGTHTGEALQFSKENLLRRFTSNNNVAIVITDGRSDTLRDRTPLTSLCEVTPVVSLGIGDIFRNNPNPDQLNDIACLGMPRRQGLSIQRDNYAELLDDSFLQNITSYVCREKKCPDYTCPITFANPADIMLLVDSSTSVGSKNFDTTKNFVKRLAERFLEASKPAEDSVRVSVVQYSGRNQQKVEVPFQRNYTVIAKAVDNMEFMNEATDVNAALQYIMGLYQRSSRAGAKKKVLVFSDGNSQGITARAIERTVQEVQQAGIEVYVLAVGSQVNEPNVRVLVTGKSTNYDVAYGERHLFRVPDYTSLLRGVFYQTVSRKIAVD", "length": 1151 }, "evidence": [ { "id": "E1BI98", "url": "https://omabrowser.org/oma/group/E1BI98/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZUL3-1", "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "Col6a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVTRRPAGNMRLAHTLLPLLLQACWVAAQDIQGSRAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLMRMPSGRDELKASIDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEETISQTIDTIVDMIKNNVEQVCCTFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGLKGEKGEAGAEGEAGRPGNSGPPGDEGEPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDPGESGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGINGTKGYPGLKGDEGEAGDPGEDNNDVSPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGSDIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQSRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPTDITILLDSSASVGSHNFETTKVFAKRLAERFLSAGREDPTQVVRVAVVQYSGQGQQQPGRASLQFQQNYTVLASSVDSMDFINDATDVNDALSYVTRFYRENSSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRGGIEIFVMVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG", "length": 1034 }, "evidence": [ { "id": "E1BI98", "url": "https://omabrowser.org/oma/group/E1BI98/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P12109-1", "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "COL6A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAARALLPLLLQACWTAAQDEPETPRAVAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLVGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQVCCSFECQPARGPPGLRGDPGFEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGVKGEMGYPGLPGCKGSPGFDGIQGPPGPKGDPGAFGLKGEKGEPGADGEAGRPGSSGPSGDEGQPGEPGPPGEKGEAGDEGNPGPDGAPGERGGPGERGPRGTPGTRGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGSEGARGAPGPAGPPGDPGLMGERGEDGPAGNGTEGFPGFPGYPGNRGAPGINGTKGYPGLKGDEGEAGDPGDDNNDIAPRGVKGAKGYRGPEGPQGPPGHQGPPGPDECEILDIIMKMCSCCECKCGPIDLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDAMDFINDATDVNDALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVVVGRQVNEPHIRVLVTGKTAEYDVAYGESHLFRVPSYQALLRGVFHQTVSRKVALG", "length": 1028 }, "evidence": [ { "id": "E1BI98", "url": "https://omabrowser.org/oma/group/E1BI98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q04857-1", "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "Col6a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGDEGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERFLSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVNDALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG", "length": 1025 }, "evidence": [ { "id": "E1BI98", "url": "https://omabrowser.org/oma/group/E1BI98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" }, { "name": "collagen type VI trimer", "id": "GO:0005589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005589", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "E1BI98", "url": "https://www.uniprot.org/uniprotkb/E1BI98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 803, "end_pos": 805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 895, "end_pos": 897, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BI98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1027, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BI98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BI98" }, { "pdb_id": "9han", "pdb_chain": "a/d", "start_pos": 1, "end_pos": 1027, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/9han.pdb", "url_external": "https://www.rcsb.org/structure/9han" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI98" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 235, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 435, 950 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 537, "end_pos": 539 }, { "start_pos": 803, "end_pos": 805 }, { "start_pos": 895, "end_pos": 897 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BIA6-1", "uniprot_ac": "E1BIA6", "uniprot_id": "E1BIA6_BOVIN", "mass": { "chemical_mass": 65569.0, "monoisotopic_mass": 65569.0 }, "refseq": { "ac": "XP_005220106", "name": "ribonuclease SLFN12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220106" }, "gene_names": [ { "name": "SLFN12", "type": "recommended", "evidence": [ { "id": "E1BIA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIA6" } ] }, { "name": "SLFN12", "type": "synonym", "evidence": [ { "id": "XP_005220106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220106" } ] } ], "protein_names": [ { "name": "Schlafen family member 12", "type": "synonym", "evidence": [ { "id": "E1BIA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIA6/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease SLFN12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005220106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220106" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIA6", "url": "https://www.uniprot.org/uniprotkb/E1BIA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLFN12", "url": "https://www.uniprot.org/uniprotkb/E1BIA6", "locus": {} } ], "crossref": [ { "id": "E1BIA6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100848263", "url": "https://www.ncbi.nlm.nih.gov/gene/100848263", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848263", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848263", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VKMGGYT", "url": "https://omabrowser.org/oma/group/VKMGGYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIA6", "url": "https://www.orthodb.org/?gene=E1BIA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12155:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12155:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005220106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIA6", "url": "https://www.uniprot.org/uniprotkb/E1BIA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPEKMTICIVLDANYPELVLDVGKVTLGEKNRKKMKDSQLRKKQNESLSKCVITLLNSGGGISKIEIENEDYSYEKDGIGLDLEHSLADMVPIVHKYFDFMKQGKYFLIFVKSWSSKIPGMKIATLSSNLYKRDITSVNVMNATVALEFLKDRVETRERFSLTSKSSSKRCREETEESSTKALASDFFNRTQLRYREKLTFTESTYVEIKDFSTQKLLQRIKEILPQYVSAFANTRGGYLFVGLSEKKQEVIGFKAEKSDLDKIEREIEKCISELPVYHFCMEKKKINYLCKFLEVYDEESLCGYVCMLKIEPFCCAVFAKKPDSWHVKDNQVKQLSVEEWVQLMMDPEPDFPRLFEEMNFQRSMLSPIPHDWSVDKVPSEKVTYIPEILYKRLFSQHEGVAQLICKEMGSVHQGTLIFSKSWSLDLDLQENQSVICDALLISQDRPPVLYTFLRELNEELKGYSIQTALTLKKKLVKIGGYTGKVCVMTKIYCSEESSTLTEGSARLLHDSSLSATYPKSYTLITSQTMNDLKKALFIVLKSLGTLSDKFDSEIFQHLLSNQHGLLSEE", "length": 571, "header": "tr|E1BIA6-1|E1BIA6_BOVIN Isoform 1 of Schlafen family member 12 OS=Bos taurus OX=9913 GN=SLFN12 PE=4 SV=3 CANONICAL=E1BIA6-1" }, "isoforms": [ { "isoform_ac": "E1BIA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIA6/entry#E1BIA6-1", "sequence": { "sequence": "MAPEKMTICIVLDANYPELVLDVGKVTLGEKNRKKMKDSQLRKKQNESLSKCVITLLNSGGGISKIEIENEDYSYEKDGIGLDLEHSLADMVPIVHKYFDFMKQGKYFLIFVKSWSSKIPGMKIATLSSNLYKRDITSVNVMNATVALEFLKDRVETRERFSLTSKSSSKRCREETEESSTKALASDFFNRTQLRYREKLTFTESTYVEIKDFSTQKLLQRIKEILPQYVSAFANTRGGYLFVGLSEKKQEVIGFKAEKSDLDKIEREIEKCISELPVYHFCMEKKKINYLCKFLEVYDEESLCGYVCMLKIEPFCCAVFAKKPDSWHVKDNQVKQLSVEEWVQLMMDPEPDFPRLFEEMNFQRSMLSPIPHDWSVDKVPSEKVTYIPEILYKRLFSQHEGVAQLICKEMGSVHQGTLIFSKSWSLDLDLQENQSVICDALLISQDRPPVLYTFLRELNEELKGYSIQTALTLKKKLVKIGGYTGKVCVMTKIYCSEESSTLTEGSARLLHDSSLSATYPKSYTLITSQTMNDLKKALFIVLKSLGTLSDKFDSEIFQHLLSNQHGLLSEE", "length": 571, "header": "tr|E1BIA6-1|E1BIA6_BOVIN Isoform 1 of Schlafen family member 12 OS=Bos taurus OX=9913 GN=SLFN12 PE=4 SV=3 CANONICAL=E1BIA6-1" }, "locus": { "chromosome": "19", "start_pos": 14871145, "end_pos": 14864258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035354.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035354.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035229.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035229.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848263", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848263", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6IEE8-1", "protein_name": "Schlafen family member 12-like", "gene_name": "SLFN12L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLARKEFLRGNGLAAGKMNISIDLDTNYAELVLNVGRVTLGENNRKKMKDCQLRKQQNENVSRAVCALLNSGGGVIKAEVENKGYSYKKDGIGLDLENSFSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQIATLSSSLYKRDVTSAKVMNASAALEFLKDMEKTGGRAYLRPEFPAKRACVDVQEESNMEALAADFFNRTELGYKEKLTFTESTHVEIKNFSTEKLLQRITEILPQYVSAFANTDGGYLFVGLNEDKEVIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGTINYLCKFLGVYDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQLTEKEWIQFMVDSEPVCEELPSPASTSSPVSQSYPLREYINFKIQPLRYHLPGLSEKITCAPKTFCRNLFSQHEGLKQLICEEMGSVNKGSLIFSRSWSLDLGLQENHKVLCDALLISQDKPPVLYTFHMVQDEEFKDYSTQTAQTLKQKLAKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYYWTTAQTMKDLEKALSNILPKENQIFLFVCLFRFCLFVCWFVCFFLR", "length": 588 }, "evidence": [ { "id": "E1BIA6", "url": "https://omabrowser.org/oma/group/E1BIA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 571, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIA6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIA6" }, { "id": "PF17057", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Poxin-Schlafen/Schlafen-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 202, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BIA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIA6" }, { "id": "PF04326", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04326" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Schlafen AlbA-2", "eco_id": "ECO_0000259", "start_pos": 204, "end_pos": 332, "start_aa": "Glu", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BIA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIA6" }, { "id": "PF21026", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Schlafen GTPase-like", "eco_id": "ECO_0000259", "start_pos": 382, "end_pos": 525, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIB4-1", "uniprot_ac": "E1BIB4", "uniprot_id": "E1BIB4_BOVIN", "mass": { "chemical_mass": 64076.0, "monoisotopic_mass": 64076.0 }, "refseq": { "ac": "NP_001178959", "name": "heterogeneous nuclear ribonucleoprotein L", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178959" }, "gene_names": [ { "name": "HNRNPL", "type": "recommended", "evidence": [ { "id": "E1BIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ] }, { "name": "HNRNPL", "type": "synonym", "evidence": [ { "id": "NP_001178959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178959" } ] } ], "protein_names": [ { "name": "Heteroous nuclear ribonucleoprotein L", "type": "synonym", "evidence": [ { "id": "E1BIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIB4/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein L", "type": "synonym", "evidence": [ { "id": "NP_001178959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178959" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNRNPL", "url": "https://www.uniprot.org/uniprotkb/E1BIB4", "locus": { "chromosome": "18", "start_pos": 48557658, "end_pos": 48569498, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001055", "url": "https://www.ensembl.org/id/ENSBTAG00000001055" } ] } } ], "crossref": [ { "id": "E1BIB4", "url": "https://alphafold.ebi.ac.uk/entry/E1BIB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001055", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12699", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12699", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12780", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12780", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504520", "url": "https://www.ncbi.nlm.nih.gov/gene/504520", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504520", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504520", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYNAQYP", "url": "https://omabrowser.org/oma/group/VYNAQYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIB4", "url": "https://www.orthodb.org/?gene=E1BIB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22976", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22976", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72203", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T365", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T365", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T365-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T365-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 588, "header": "tr|E1BIB4-1|E1BIB4_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein L OS=Bos taurus OX=9913 GN=HNRNPL PE=1 SV=2 CANONICAL=E1BIB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BIB4/entry#A0AAA9SWN9-1", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 554, "header": "tr|A0AAA9SWN9-1|A0AAA9SWN9_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein L OS=Bos taurus OX=9913 GN=HNRNPL PE=1 SV=1 CANONICAL=E1BIB4-1" }, "locus": { "chromosome": "18", "start_pos": 48569483, "end_pos": 48558274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113506.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113506.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088651.1" } ] } }, { "isoform_ac": "A0AAA9T365-1", "url": "https://www.uniprot.org/uniprotkb/E1BIB4/entry#A0AAA9T365-1", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPTRKFSPALPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 625, "header": "tr|A0AAA9T365-1|A0AAA9T365_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein L OS=Bos taurus OX=9913 GN=HNRNPL PE=1 SV=1 CANONICAL=E1BIB4-1" }, "locus": { "chromosome": "18", "start_pos": 48569483, "end_pos": 48558274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102670.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102670.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091067.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091067.1" } ] } }, { "isoform_ac": "E1BIB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIB4/entry#E1BIB4-1", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 588, "header": "tr|E1BIB4-1|E1BIB4_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein L OS=Bos taurus OX=9913 GN=HNRNPL PE=1 SV=2 CANONICAL=E1BIB4-1" }, "locus": { "chromosome": "18", "start_pos": 48569483, "end_pos": 48558274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032051.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032051.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031993.4", "url": "https://www.ensembl.org/id/ENSBTAP00000031993.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504520", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504520", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-72203", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "resource": "Reactome", "description": "Processing of Capped Intron-Containing Pre-mRNA" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LQ48-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L", "gene_name": "Hnrnpl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 623 }, "evidence": [ { "id": "E1BIB4", "url": "https://omabrowser.org/oma/group/E1BIB4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P14866-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L", "gene_name": "HNRNPL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 589 }, "evidence": [ { "id": "E1BIB4", "url": "https://omabrowser.org/oma/group/E1BIB4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54YS7-1", "protein_name": "RNA-binding region RNP-1 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDIKKREFDNSTDQLGSYGENNDSKRLKLEIENEIDKSIEPSPVIHCRGLPYSVTDADIHALLSPFGKVEAVCLMRMGQALIEMDSIQTSTSIISLSITKPFILHNQKILFAYSKSQHLNNSKKNQPIAQTGSQNIILCTILNPIYPITTNTIHNIMSPYGRVIRIVIFQKKSGLQTFVEFDSPYSAWAAKESLNGQDIYNGGCKLQIEFARVSKLNVKQNDDKTADYTAEFYQMQQQQQMASLGSPYAMPTQGGPMGNPFSTVPHHHGSMGHHHSPFTSVVGGGGGGGAPMGIDKSMMYSQSAMSSYMYNIVGGQESLSQPVILVNRLPETLDTDKLFNLFCLYGNVIKIKMLHNTKGSAMVQMGDSVQAEIAIQCLNQSSVYGQKIGVFHTKYQYIVESEKTRDYSKSTLNRFLNNQPYGKNAYKPSPTLHFLNVPLNFTEKQLIDEFTNFGTHTPTHCKFFPTKPESTKLMGLLEFPDSRLATEALMDLNNHKITGNVLKLSFTMNTIHKTEQTQPLQPPQPPPNLS", "length": 530 }, "evidence": [ { "id": "E1BIB4", "url": "https://omabrowser.org/oma/group/E1BIB4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8R081-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L", "gene_name": "Hnrnpl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS", "length": 586 }, "evidence": [ { "id": "E1BIB4", "url": "https://omabrowser.org/oma/group/E1BIB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "pre-mRNA intronic binding", "id": "GO:0097157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097157", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "pronucleus", "id": "GO:0045120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045120", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "E1BIB4", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIB4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 588, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIB4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIB4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIB4" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 175, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 288, "end_pos": 290 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIE3-1", "uniprot_ac": "E1BIE3", "uniprot_id": "E1BIE3_BOVIN", "mass": { "chemical_mass": 24529.0, "monoisotopic_mass": 24529.0 }, "refseq": {}, "gene_names": [ { "name": "C17H22orf15", "type": "recommended", "evidence": [ { "id": "E1BIE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE3" } ] } ], "protein_names": [ { "name": "Chromosome 17 C22orf15 homolog", "type": "synonym", "evidence": [ { "id": "E1BIE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIE3", "url": "https://www.uniprot.org/uniprotkb/E1BIE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C17H22orf15", "url": "https://www.uniprot.org/uniprotkb/E1BIE3", "locus": { "chromosome": "17", "start_pos": 71225401, "end_pos": 71223882, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022030", "url": "https://www.ensembl.org/id/ENSBTAG00000022030" } ] } } ], "crossref": [ { "id": "E1BIE3", "url": "https://alphafold.ebi.ac.uk/entry/E1BIE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022030", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022030", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR039471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RTWMTSV", "url": "https://omabrowser.org/oma/group/RTWMTSV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR33887", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33887", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33887:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33887:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BIE3", "url": "https://www.uniprot.org/uniprotkb/E1BIE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIE3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFIKVMFGASCWELVNTWCGLGTLTAHLRQSGQVPPDASVALLAEDGHLVSLAEGLEEGPSPAPSVASPPLLPVIRLPPSTEGEGGDPTRYECLLENPDGWHPELAGECHSHRRAWGQGHLPTRTLRQGFPGLTEEPRWRRACSLRATAGGGAWALGVASRSKVPLHSPEGWAPCCPGPRSRGLEPGKEETRTPGGCSHPEMGPPSQGTDVCAERWTAMPASLRDTRKAT", "length": 230, "header": "tr|E1BIE3-1|E1BIE3_BOVIN Isoform 1 of Chromosome 17 C22orf15 homolog OS=Bos taurus OX=9913 GN=C17H22orf15 PE=4 SV=2 CANONICAL=E1BIE3-1" }, "isoforms": [ { "isoform_ac": "E1BIE3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIE3/entry#E1BIE3-1", "sequence": { "sequence": "MFIKVMFGASCWELVNTWCGLGTLTAHLRQSGQVPPDASVALLAEDGHLVSLAEGLEEGPSPAPSVASPPLLPVIRLPPSTEGEGGDPTRYECLLENPDGWHPELAGECHSHRRAWGQGHLPTRTLRQGFPGLTEEPRWRRACSLRATAGGGAWALGVASRSKVPLHSPEGWAPCCPGPRSRGLEPGKEETRTPGGCSHPEMGPPSQGTDVCAERWTAMPASLRDTRKAT", "length": 230, "header": "tr|E1BIE3-1|E1BIE3_BOVIN Isoform 1 of Chromosome 17 C22orf15 homolog OS=Bos taurus OX=9913 GN=C17H22orf15 PE=4 SV=2 CANONICAL=E1BIE3-1" }, "locus": { "chromosome": "17", "start_pos": 71225398, "end_pos": 71223953, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029461.3", "url": "https://www.ensembl.org/id/ENSBTAT00000029461.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029461.2", "url": "https://www.ensembl.org/id/ENSBTAP00000029461.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIE3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIE3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIE3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIH0-1", "uniprot_ac": "E1BIH0", "uniprot_id": "E1BIH0_BOVIN", "mass": { "chemical_mass": 13378.0, "monoisotopic_mass": 13378.0 }, "refseq": { "ac": "XP_002695222", "name": "insulin growth factor-like family member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695222" }, "gene_names": [ { "name": "IGFL1", "type": "recommended", "evidence": [ { "id": "E1BIH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH0" } ] }, { "name": "IGFL1", "type": "synonym", "evidence": [ { "id": "XP_002695222", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695222" } ] } ], "protein_names": [ { "name": "IGF like family member 1", "type": "synonym", "evidence": [ { "id": "E1BIH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH0/entry#names_and_taxonomy" } ] }, { "name": "insulin growth factor-like family member 1", "type": "synonym", "evidence": [ { "id": "XP_002695222", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695222" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIH0", "url": "https://www.uniprot.org/uniprotkb/E1BIH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGFL1", "url": "https://www.uniprot.org/uniprotkb/E1BIH0", "locus": { "chromosome": "18", "start_pos": 53529676, "end_pos": 53532226, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000027", "url": "https://www.ensembl.org/id/ENSBTAG00000000027" } ] } } ], "crossref": [ { "id": "E1BIH0", "url": "https://alphafold.ebi.ac.uk/entry/E1BIH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000027", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000027", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512788", "url": "https://www.ncbi.nlm.nih.gov/gene/512788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512788", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512788", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BIH0", "url": "https://www.orthodb.org/?gene=E1BIH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34827:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34827:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695222", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695222", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIH0", "url": "https://www.uniprot.org/uniprotkb/E1BIH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BIH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPRRCILAVLAAVCILLLLCSHAAPVSPTGTQLLLCQSQERCGDQFYDPRQDCCCDDAVVPLGRTRKCGNCTFRVCFEQCCPWLVNRPQESFVVKVKGQNCYSAVSSDDRVCGRSKPGGTL", "length": 122, "header": "tr|E1BIH0-1|E1BIH0_BOVIN Isoform 1 of IGF like family member 1 OS=Bos taurus OX=9913 GN=IGFL1 PE=3 SV=4 CANONICAL=E1BIH0-1" }, "isoforms": [ { "isoform_ac": "E1BIH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BIH0/entry#E1BIH0-1", "sequence": { "sequence": "MTPRRCILAVLAAVCILLLLCSHAAPVSPTGTQLLLCQSQERCGDQFYDPRQDCCCDDAVVPLGRTRKCGNCTFRVCFEQCCPWLVNRPQESFVVKVKGQNCYSAVSSDDRVCGRSKPGGTL", "length": 122, "header": "tr|E1BIH0-1|E1BIH0_BOVIN Isoform 1 of IGF like family member 1 OS=Bos taurus OX=9913 GN=IGFL1 PE=3 SV=4 CANONICAL=E1BIH0-1" }, "locus": { "chromosome": "18", "start_pos": 53532194, "end_pos": 53529837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031806.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031806.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031752.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031752.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512788", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512788", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "E1BIH0", "url": "https://www.uniprot.org/uniprotkb/E1BIH0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BIH0", "url": "https://www.uniprot.org/uniprotkb/E1BIH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIH0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 122, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIH0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIH0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BII6-1", "uniprot_ac": "E1BII6", "uniprot_id": "E1BII6_BOVIN", "mass": { "chemical_mass": 16915.0, "monoisotopic_mass": 16915.0 }, "refseq": { "ac": "XP_002692279", "name": "uncharacterized protein C20orf141 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692279" }, "gene_names": [ { "name": "C13H20orf141", "type": "recommended", "evidence": [ { "id": "E1BII6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII6" } ] }, { "name": "C13H20orf141", "type": "synonym", "evidence": [ { "id": "XP_002692279", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692279" } ] } ], "protein_names": [ { "name": "Chromosome 13 C20orf141 homolog", "type": "synonym", "evidence": [ { "id": "E1BII6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII6/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C20orf141 homolog", "type": "synonym", "evidence": [ { "id": "XP_002692279", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692279" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BII6", "url": "https://www.uniprot.org/uniprotkb/E1BII6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C13H20orf141", "url": "https://www.uniprot.org/uniprotkb/E1BII6", "locus": { "chromosome": "13", "start_pos": 52366497, "end_pos": 52367078, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021817", "url": "https://www.ensembl.org/id/ENSBTAG00000021817" } ] } } ], "crossref": [ { "id": "E1BII6", "url": "https://alphafold.ebi.ac.uk/entry/E1BII6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021817", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021817", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "788725", "url": "https://www.ncbi.nlm.nih.gov/gene/788725", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788725", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788725", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HTHLTRG", "url": "https://omabrowser.org/oma/group/HTHLTRG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BII6", "url": "https://www.orthodb.org/?gene=E1BII6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR39222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39222:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39222:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002692279", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692279", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BII6", "url": "https://www.uniprot.org/uniprotkb/E1BII6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BII6-1", "url": "https://www.uniprot.org/uniprotkb/E1BII6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHLCLPRPEAAVSPTPGPPRGMGAGEGSASPVGPCVSPWGPSWAQVLDSVLGLGALGLTIRAIFSTTGPALLLLLLLVSFLAFDMLHRPAGPTWSQHTHLTRGQSQGAGEGPEQQEAPPAVAVAGRLSLQEALLLLCLGAGLLLGARGVPLTLLALAFCLHPWT", "length": 165, "header": "tr|E1BII6-1|E1BII6_BOVIN Isoform 1 of Chromosome 13 C20orf141 homolog OS=Bos taurus OX=9913 GN=C13H20orf141 PE=4 SV=2 CANONICAL=E1BII6-1" }, "isoforms": [ { "isoform_ac": "E1BII6-1", "url": "https://www.uniprot.org/uniprotkb/E1BII6/entry#E1BII6-1", "sequence": { "sequence": "MTHLCLPRPEAAVSPTPGPPRGMGAGEGSASPVGPCVSPWGPSWAQVLDSVLGLGALGLTIRAIFSTTGPALLLLLLLVSFLAFDMLHRPAGPTWSQHTHLTRGQSQGAGEGPEQQEAPPAVAVAGRLSLQEALLLLCLGAGLLLGARGVPLTLLALAFCLHPWT", "length": 165, "header": "tr|E1BII6-1|E1BII6_BOVIN Isoform 1 of Chromosome 13 C20orf141 homolog OS=Bos taurus OX=9913 GN=C13H20orf141 PE=4 SV=2 CANONICAL=E1BII6-1" }, "locus": { "chromosome": "13", "start_pos": 52367078, "end_pos": 52366500, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029079.2", "url": "https://www.ensembl.org/id/ENSBTAT00000029079.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029079.2", "url": "https://www.ensembl.org/id/ENSBTAP00000029079.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 16, "start_aa": "Thr", "end_pos": 16, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr16", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 94, "start_aa": "Thr", "end_pos": 94, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr94", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:788725", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788725", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SHR5-1", "protein_name": "Chromosome 17 C20orf141 homolog", "gene_name": "C20orf141", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTQLCSSRPKGPAYSIPGLPRGLGAGEGSGSPVGPCVSPGGPSPAQLLDSVLGLGALGLTIWAVFSTTGPASLLLLLLLVSFLAFDLLHRPAGPTWPQHTHPRLTGGQSQGAGEGPGQVEALLLPTVGTGQLALQEALLMLLLGLGLLLGARGMPLTLLALAFCLHPWA", "length": 169 }, "evidence": [ { "id": "E1BII6", "url": "https://omabrowser.org/oma/group/E1BII6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9NUB4-1", "protein_name": "Uncharacterized protein C20orf141", "gene_name": "C20orf141", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVLWLGALGLTIQAVFSTTGPALLLLLVSFLTFDLLHRPAGHTLPQRKLLTRGQSQGAGEGPGQQEALLLQMGTVSGQLSLQDALLLLLMGLGPLLRACGMPLTLLGLAFCLHPWA", "length": 165 }, "evidence": [ { "id": "E1BII6", "url": "https://omabrowser.org/oma/group/E1BII6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BII6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BII6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BII6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 16, 94 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIJ1-1", "uniprot_ac": "E1BIJ1", "uniprot_id": "E1BIJ1_BOVIN", "mass": { "chemical_mass": 58802.0, "monoisotopic_mass": 58802.0 }, "refseq": { "ac": "NP_001179659", "name": "DEP domain-containing protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179659" }, "gene_names": [ { "name": "DEPDC7", "type": "recommended", "evidence": [ { "id": "E1BIJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1" } ] }, { "name": "DEPDC7", "type": "synonym", "evidence": [ { "id": "NP_001179659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179659" } ] } ], "protein_names": [ { "name": "DEP domain-containing protein 7", "type": "recommended", "evidence": [ { "id": "E1BIJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1/entry#names_and_taxonomy" } ] }, { "name": "DEP domain-containing protein 7", "type": "synonym", "evidence": [ { "id": "NP_001179659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179659" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIJ1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DEPDC7", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1", "locus": { "chromosome": "15", "start_pos": 63682358, "end_pos": 63659390, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021809", "url": "https://www.ensembl.org/id/ENSBTAG00000021809" } ] } } ], "crossref": [ { "id": "E1BIJ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BIJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021809", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021809", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04446", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04446", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532586", "url": "https://www.ncbi.nlm.nih.gov/gene/532586", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532586", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532586", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCTRVSA", "url": "https://omabrowser.org/oma/group/YCTRVSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIJ1", "url": "https://www.orthodb.org/?gene=E1BIJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16206:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16206:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIJ1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIJ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATVREKAAALNLSAFQSPVQRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIFSHLMQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTTPNQDSQLGKENKVCSPSRYADTLFKSSDIRSTSLEALWENLSLKPADSPRVNISATLSPQVINEVWQEETIGRLLQLIDLPLLDSLLKRQEMIPKVSQPKRQLDLVNNRNYLDRGILKAYSDSQEDEWLSSAIDCLEYLPDQMVVDISRNFPEQPDRIDLVKELLFDAISKYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLFLKLLDSQNREEFRRLLYFMAVAAHPSEFKLQQESDNRMVVKRMFSKAIVHNKNLSKGKTDLLVLFLMDHQRDVFKIPGTLHKIVSIKLMDIQKGRDPNRDAGYIYCQRIDRSDYSDHTRKTTKDELLNLLKNIDEDSKLSTKEKKKLLGQFYKCHPDVFIEYFGD", "length": 511, "header": "tr|E1BIJ1-1|E1BIJ1_BOVIN Isoform 1 of DEP domain-containing protein 7 OS=Bos taurus OX=9913 GN=DEPDC7 PE=3 SV=3 CANONICAL=E1BIJ1-1" }, "isoforms": [ { "isoform_ac": "E1BIJ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1/entry#E1BIJ1-1", "sequence": { "sequence": "MATVREKAAALNLSAFQSPVQRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIFSHLMQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTTPNQDSQLGKENKVCSPSRYADTLFKSSDIRSTSLEALWENLSLKPADSPRVNISATLSPQVINEVWQEETIGRLLQLIDLPLLDSLLKRQEMIPKVSQPKRQLDLVNNRNYLDRGILKAYSDSQEDEWLSSAIDCLEYLPDQMVVDISRNFPEQPDRIDLVKELLFDAISKYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLFLKLLDSQNREEFRRLLYFMAVAAHPSEFKLQQESDNRMVVKRMFSKAIVHNKNLSKGKTDLLVLFLMDHQRDVFKIPGTLHKIVSIKLMDIQKGRDPNRDAGYIYCQRIDRSDYSDHTRKTTKDELLNLLKNIDEDSKLSTKEKKKLLGQFYKCHPDVFIEYFGD", "length": 511, "header": "tr|E1BIJ1-1|E1BIJ1_BOVIN Isoform 1 of DEP domain-containing protein 7 OS=Bos taurus OX=9913 GN=DEPDC7 PE=3 SV=3 CANONICAL=E1BIJ1-1" }, "locus": { "chromosome": "15", "start_pos": 63682226, "end_pos": 63659440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029070.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029070.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029070.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029070.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532586", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532586", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QPH6-1", "protein_name": "DEP domain-containing protein 7", "gene_name": "Depdc7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATVREKAAALNLSALHSPAQKPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFIGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVPTRVFGKDKKPPFEDSSCSLYRFTTIPGQNSQSGNENKVDSPSRYSDTLFQSPEIKSDSLEDLWENLSLKPANSPHINISTRLSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKVPRSKKQPDMVNTSNYLDRGILRAYGDSQEDEWVSAAIDCLEYLPDHMVVDISRNFPEQPDRTDLVKELLFDAIGKYYSTREPLLNHLCDVHNGIAELLVNGKTEIALEATQLFLKLLDSQNREEFRRLLYFMAVAAHPSEFKLQEESDNRMVVKRVFSKAVVNNKNLSKGKTDLLVLFLMDHQKDVFKIPATLHKIVSVKLLAIQKGRDPNKDTGYIYCQRIDESDYSGSKQKKTKEELLNLLKTIDEDSKLSAKEKKKLLGQFHKCHPDIFTEYFGN", "length": 511 }, "evidence": [ { "id": "E1BIJ1", "url": "https://omabrowser.org/oma/group/E1BIJ1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZKW7-1", "protein_name": "DEP domain-containing protein 7", "gene_name": "DEPDC7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATVREKAAALSLSAVCSPATRPPGFSLAQKPFGATYVWSSIISALQTQVEVKKRRQNLKCYHDCFIGSDAVDVVFAHLLQNKYFGDVDISRAKVVRVCQALMDYKVFEAVSRRVFGKDKRSVFEDSSSSLYRFTNVSSQADLDKDYQQCTPQRHQKNTLFNTTPVKAESLEDLWENLSLKPANTPQVNISESLSRRVINEVWREQTIARLLQLVDLPLLDSLLEHQAVKPQLPQPKEDSGYVITSNYLDREILKAFSDSQTDEWLSSAIDCLEYLPDHMVVDISRNLPDQLDKADTWKLLLFENIGRYYGQKKEPLLSHAPEVHSGIAELLVNGKMEQSLEAIQLYLKLLDSQIREEFRRLLYFMAVAAHNSELKLQKESDNRMVVKRTFSKAIINNKSLSRGKTDLLILFLVDHQKDVLKIPGTLHKMVSNKLMALQEGQDPSKIAGYTFCQKLDEREYRLNTEKTTKDELLSLLKAIDEDSKLSEKERKRLLGQFHSSNPSIFMQYFGDRVPNMCM", "length": 519 }, "evidence": [ { "id": "E1BIJ1", "url": "https://omabrowser.org/oma/group/E1BIJ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q4QR86-1", "protein_name": "DEP domain-containing protein 7", "gene_name": "Depdc7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATVREKAAALDLSALHSPAQRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVQTRVFGKDKKPAFEDSSCSLYRFTTIPNQDSQLGHENKGTSPSRFSDALFKSSDIKSDSLEDLWENLSLKPTNSPHVSTRLSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKAPQSKRQPDMVNTSNYLDRGILRAYGDSQEDEWISAAIDCLEYLPDQMVVDISRNFPEQPDRTDLVKELLFGAIGKYYSTREPLLNHLSDVHNGIAELLVNGKTEIALEATQLFLKLLDSQNREEFRRLLYFMAVAADPSEFKLQEESDNRMVVKRVFSKAIVNNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLLAIQKGRDPNKDTGYIYCQRIDGREYSSSIQKKTKDQLLSLLKTIDEDSKLSAKEKKKLLGQFHKSHPDIFIEYFGDSF", "length": 511 }, "evidence": [ { "id": "E1BIJ1", "url": "https://omabrowser.org/oma/group/E1BIJ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91WS7-1", "protein_name": "DEP domain-containing protein 7", "gene_name": "Depdc7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVREKAAALNLSALHSPAQRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVQTRVFGKDKKPTFEDSSCSLYRFTTIPNQDNQLGHENKVHSPSRYSDASFMSSDIKSDSLEDLWENLSLKPASSPHIHISTRLSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKAPQSKRQPDMVNTSNYLDRGILRAYGDSQEDEWISAAIDCLEYLPDQMVVDISRNFPEQPDRTDLVKELLFDAIGRYYSTREPLLNHLYDVHNGIAELLVNGKTEMALEATQLFLKLQDSQNREEFRRLLYFMAVAADPSEFKLQEESDNRMVVKRVFSKAIVNNKNVSKGKTDLLVLFLMDHQKDVFKIPAALHKIVSVKLLAIQKGRDPNKDTGYIYCQRIDESEYSSSTKKKTKDQLLSLLKTIDEDSKLSAKEKKKLLGQFRKTHPDIFTEYFGD", "length": 511 }, "evidence": [ { "id": "E1BIJ1", "url": "https://omabrowser.org/oma/group/E1BIJ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96QD5-1", "protein_name": "DEP domain-containing protein 7", "gene_name": "DEPDC7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD", "length": 511 }, "evidence": [ { "id": "E1BIJ1", "url": "https://omabrowser.org/oma/group/E1BIJ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BIJ1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIJ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 511, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIJ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIJ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ1" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 136, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 189, "end_pos": 191 }, { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIJ3-1", "uniprot_ac": "E1BIJ3", "uniprot_id": "E1BIJ3_BOVIN", "mass": { "chemical_mass": 124944.0, "monoisotopic_mass": 124944.0 }, "refseq": {}, "gene_names": [ { "name": "CASKIN2", "type": "recommended", "evidence": [ { "id": "E1BIJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" } ] } ], "protein_names": [ { "name": "Caskin-2", "type": "recommended", "evidence": [ { "id": "E1BIJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.", "evidence": [ { "database": "UniProtKB", "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3#function" }, { "database": "UniProtKB", "id": "ARBA00025297", "url": "https://www.uniprot.org/uniprotkb/ARBA00025297#function" }, { "database": "UniProtKB", "id": "A0AAA9SKH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASKIN2", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3", "locus": { "chromosome": "19", "start_pos": 56043099, "end_pos": 56030494, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007220", "url": "https://www.ensembl.org/id/ENSBTAG00000007220" } ] } } ], "crossref": [ { "id": "E1BIJ3", "url": "https://alphafold.ebi.ac.uk/entry/E1BIJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007220", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007220", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09497", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09497", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09498", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09498", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HIHESHR", "url": "https://omabrowser.org/oma/group/HIHESHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIJ3", "url": "https://www.orthodb.org/?gene=E1BIJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIJ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKAGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGVLAPRLPSVPTPLRPGFSRMPQPPAEEPLHPLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHSTGLLIENAQPLPSAGEDQVPPGLQPASLADNPNHRPLANYRSGEQHFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPADLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGESLGEGGRRLARGPELMAIEGLENGDGPPAASPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPNTPQERNLPEGTERPPKLCSPLPSQGPPPYVFMYPQASPSSPAPGPPPGAPRAFSYLAGPPATPPDPPRPKRRSHSLSRPGPAEGEADGEAEGPVDSALGSYATLTRRPGRSTLARTSPSPTPTRGAPRSQSFALRARRKGPPPPPPKRLSSVSGSTPEPPPPDESPGPKEGAAGPRRRTLSEPTGPSEPSGPPTPAGAASDTEEEDPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPAGLDFNLTESDTVKRRPKCREREPLQTALLAFGVAGTTPNSPAPQPSQTPSEPPAASPSPPQPDPSSLPTPGAPALSLPAPRPSPSGPPWKTIGGPGRRSPRLPPPPSSRCPEQEQPPSLCPWPAPSWHFPALSWLPGSAPARCPLQGRRAQGPRAQAGPSRDWSRPARPWQLHCEPRRRALALRSERAPPAPPPSTS", "length": 1173, "header": "tr|E1BIJ3-1|E1BIJ3_BOVIN Isoform 1 of Caskin-2 OS=Bos taurus OX=9913 GN=CASKIN2 PE=4 SV=3 CANONICAL=E1BIJ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3/entry#A0AAA9SKH7-1", "sequence": { "sequence": "MSTTRMLMGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKAGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGVLAPRLPSVPTPLRPGFSRMPQPPAEEPLHPLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHSTGLLIENAQPLPSAGEDQVPPGLQPASLADNPNHRPLANYRSGEQHFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPADLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGESLGEGGRRLARGPELMAIEGLENGDGPPAASPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPNTPQERNLPEGTERPPKLCSPLPSQGPPPYVFMYPQASPSSPAPGPPPGAPRAFSYLAGPPATPPDPPRPKRRSHSLSRPGPAEGEADGEAEGPVDSALGSYATLTRRPGRSTLARTSPSPTPTRGAPRSQSFALRARRKGPPPPPPKRLSSVSGSTPEPPPPDESPGPKEGAAGPRRRTLSEPTGPSEPSGPPTPAGAASDTEEEDPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPAGLDFNLTESDTVKRRPKCREREPLQTALLAFGVAGTTPNSPAPQPSQTPSEPPAASPSPPQPDPSSLPTPGAPALSLPAPRPSPSGPPWKTIGGPGRRSPRLPPPPSSRCPEQEQPPSLCPWPAPSWHFPALSWLPGSAPARCPLQGRRAQGPRAQAGPSRDWSRPARPWQLHCEPRRRALALRSERAPPAPPPSTS", "length": 1100, "header": "tr|A0AAA9SKH7-1|A0AAA9SKH7_BOVIN Computationally mapped isoform of CASK interacting protein 2 OS=Bos taurus OX=9913 GN=CASKIN2 PE=4 SV=1 CANONICAL=E1BIJ3-1" }, "locus": { "chromosome": "19", "start_pos": 56042208, "end_pos": 56035229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101065.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101065.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085796.1" } ] } }, { "isoform_ac": "E1BIJ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3/entry#E1BIJ3-1", "sequence": { "sequence": "MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKAGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGVLAPRLPSVPTPLRPGFSRMPQPPAEEPLHPLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHSTGLLIENAQPLPSAGEDQVPPGLQPASLADNPNHRPLANYRSGEQHFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPADLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGESLGEGGRRLARGPELMAIEGLENGDGPPAASPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPNTPQERNLPEGTERPPKLCSPLPSQGPPPYVFMYPQASPSSPAPGPPPGAPRAFSYLAGPPATPPDPPRPKRRSHSLSRPGPAEGEADGEAEGPVDSALGSYATLTRRPGRSTLARTSPSPTPTRGAPRSQSFALRARRKGPPPPPPKRLSSVSGSTPEPPPPDESPGPKEGAAGPRRRTLSEPTGPSEPSGPPTPAGAASDTEEEDPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPAGLDFNLTESDTVKRRPKCREREPLQTALLAFGVAGTTPNSPAPQPSQTPSEPPAASPSPPQPDPSSLPTPGAPALSLPAPRPSPSGPPWKTIGGPGRRSPRLPPPPSSRCPEQEQPPSLCPWPAPSWHFPALSWLPGSAPARCPLQGRRAQGPRAQAGPSRDWSRPARPWQLHCEPRRRALALRSERAPPAPPPSTS", "length": 1173, "header": "tr|E1BIJ3-1|E1BIJ3_BOVIN Isoform 1 of Caskin-2 OS=Bos taurus OX=9913 GN=CASKIN2 PE=4 SV=3 CANONICAL=E1BIJ3-1" }, "locus": { "chromosome": "19", "start_pos": 56042208, "end_pos": 56030693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009497.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009497.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009497.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009497.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1045, "start_aa": "Thr", "end_pos": 1045, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1045", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 787, "start_aa": "Thr", "end_pos": 787, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr787", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 846, "start_aa": "Thr", "end_pos": 846, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr846", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 919, "start_aa": "Thr", "end_pos": 919, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr919", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 937, "start_aa": "Thr", "end_pos": 937, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr937", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BC09-1", "protein_name": "Caskin-2", "gene_name": "CASKIN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGREQDLILAVKNGDVTGVQKLVAKVKAAKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGVLAPRLPSAPTPLRPGVPRMAQPPAHDPLHPLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPLAGEDQVLPGLQPPPLADNLNHRPPANFRSGEQLFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPADLLEWLCALGLPQYHKQLVSSGYDSMGLVAELTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEAPGEGGRQLARGPELMAIEGLENGEGPAAAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPGGADPNAPQERNLPEGTERPPKLCSPLPGQGAPPYVFMYPQGSPSSPAPGPPPGAPRAFSYLAGPPATPPDPPRPKRRSHSLSRPGPAEGEAEGEAEGPVDSALGSYATLTRRPGRSALVRTSPSPTPTRGAPRSQSFALRARRKGPPPPPPKRLSSVSGPTSEPPLLDGSPGPKEGAPGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPAGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPSPATATPLPSQPPSEPPSASPSPSRPDPSSLPAPGAPAPLCPSPPTQPPCPGPALENSQRPGEMEPPAAPAALIKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGASGPGQAQQRLEQTSSSLAAALRAAEKSIGAEEREGPPGTSTKHILDDISTMFDALANQLDAMLD", "length": 1197 }, "evidence": [ { "id": "E1BIJ3", "url": "https://omabrowser.org/oma/group/E1BIJ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A9T0-1", "protein_name": "Caskin-2", "gene_name": "Caskin2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKRLNINYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVKLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLKAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNIRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGIPVTRLPSAPTLLRPSFSRISQPSADDPLPSLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHSTGLLIENAQPLPSANEDQVLPGLHAPSPADNLSHRPLASYRSGEIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLHGEALGEGGRRMTRGPELMAIEGLENGDSPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQGQPGSQPNAGEPSAPQERNLPEGTERPFKPCSPLPGQGPAPYVFMCPQSLPSSPAPAPPPGVPRAFSYLAGSSAAPPDPPRPKRRSHSLSRPGPAEGEAEGEAEGPVGSALGSYATLTRRPGRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPPPKRLSSVSGSTEPTSLEGTSGPKEGAAGPRRRTLSEPTGPSESPAPSAPTGPVSDTEEEEPVLEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETTVPPGLDFNLTESDTVKRRPKCKEREPLRTALLAFGVVGSDTPGPSTPLSSQAPCEAPSAPSNPPRSEPSSLPSQEAPAPLSPVTQPPGHPGPSAGPGLETSTGSRQNVDTEPPAPPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQRLEQTSSSLEAALRAAEKNIGSEEQDGPTGPSTKHILDDISTMFDALADQLDAMLD", "length": 1200 }, "evidence": [ { "id": "E1BIJ3", "url": "https://omabrowser.org/oma/group/E1BIJ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHK1-1", "protein_name": "Caskin-2", "gene_name": "Caskin2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKRLNINYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLKAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGIPVARLPSAPTPLRPSFSRISQPAADDPLPSVPYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGTGLLIENAQPLPSASEDQGLPGLHAPSPADNLSHRPLAGYRSGEIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLHGEALGEGGRRMTRGPELMAIEGLENGEGPTTAGPRLLTFQGSELSPELQAAMAGGGSEPLPLPPARSPSQESIGARSRGSGHSQEQPVPQPSVGDPSAPQERNLPEGTERPSKLCSPLPGQGPAPYVFMCPQNLPSSPAPGPPPGVPRAFSYLAGSPAAPPDPPRPKRRSHSLSRPGPAEGEAEGEAEGPVGSALGSYATLTRRPGRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPPPKRLSSVSGSTEPPSLDGTSGPKEGATGPRRRTLSEPTGPSESPGPSAPTGPVSDTEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCKEREPLQTALLAFGVVGSDTPGPSNPLSTQAPCDPPSASSNPPQRSEPSVLPSQGTSASSLSSVTQSPGHPGPSAGPALANSTGSKPNVETEPPAPPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQRLEQTSSSLEAALRAAEKSIGTEERDGPTGTSTKHILDDISTMFDALADQLDAMLD", "length": 1201 }, "evidence": [ { "id": "E1BIJ3", "url": "https://omabrowser.org/oma/group/E1BIJ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BIJ3", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 955, "end_pos": 957, "annotation": "n_glycosylation_sequon" }, { "start_pos": 981, "end_pos": 983, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1173, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIJ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 489, "end_pos": 552, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BIJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIJ3" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 281, "end_pos": 347, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 787, 846, 919, 937, 1045 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 955, "end_pos": 957 }, { "start_pos": 981, "end_pos": 983 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIL6-1", "uniprot_ac": "E1BIL6", "uniprot_id": "E1BIL6_BOVIN", "mass": { "chemical_mass": 65166.0, "monoisotopic_mass": 65166.0 }, "refseq": { "ac": "NP_001178125", "name": "actin-binding protein IPP", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178125" }, "gene_names": [ { "name": "IPP", "type": "recommended", "evidence": [ { "id": "E1BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ] }, { "name": "IPP", "type": "synonym", "evidence": [ { "id": "NP_001178125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178125" } ] } ], "protein_names": [ { "name": "Actin-binding protein IPP", "type": "recommended", "evidence": [ { "id": "E1BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL6/entry#names_and_taxonomy" } ] }, { "name": "Intracisternal A particle-promoted polypeptide", "type": "synonym", "evidence": [ { "id": "E1BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL6/entry#names_and_taxonomy" } ] }, { "name": "actin-binding protein IPP", "type": "synonym", "evidence": [ { "id": "NP_001178125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178125" } ] } ], "function": [ { "annotation": "May play a role in organizing the actin cytoskeleton.", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6#function" }, { "database": "UniProtKB", "id": "ARBA00053616", "url": "https://www.uniprot.org/uniprotkb/ARBA00053616#function" }, { "database": "UniProtKB", "id": "A0ABI0NP37", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP37#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IPP", "url": "https://www.uniprot.org/uniprotkb/E1BIL6", "locus": { "chromosome": "3", "start_pos": 100369992, "end_pos": 100332922, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016377", "url": "https://www.ensembl.org/id/ENSBTAG00000016377" } ] } } ], "crossref": [ { "id": "E1BIL6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016377", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016377", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18256", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18256", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18466", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18466", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785293", "url": "https://www.ncbi.nlm.nih.gov/gene/785293", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785293", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785293", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYDPRDN", "url": "https://omabrowser.org/oma/group/CYDPRDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N0A6", "url": "https://www.orthodb.org/?gene=A0A3Q1N0A6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIL6", "url": "https://www.orthodb.org/?gene=E1BIL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178125", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0A6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0A6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0A6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP37", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP37-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIL6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANEGCAKAGDSHFSLDKHAQLILAQINKMRNGEHFCDVELQVGKETFKVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQILLDFIYTGIVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLVKYIEGISDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTVERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGIELCSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGLCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584, "header": "tr|E1BIL6-1|E1BIL6_BOVIN Isoform 1 of Actin-binding protein IPP OS=Bos taurus OX=9913 GN=IPP PE=4 SV=2 CANONICAL=E1BIL6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N0A6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL6/entry#A0A3Q1N0A6-1", "sequence": { "sequence": "MANEGCAKAGDSHFSLDKHAQLILAQINKMRNGEHFCDVELQVGKETFKVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQILLDFIYTGIVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLVKYIEGISDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGGWVGAEIGNTVERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGIELCSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGLCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 538, "header": "tr|A0A3Q1N0A6-1|A0A3Q1N0A6_BOVIN Computationally mapped isoform of Intracisternal A particle-promoted polypeptide OS=Bos taurus OX=9913 GN=IPP PE=4 SV=1 CANONICAL=E1BIL6-1" }, "locus": { "chromosome": "3", "start_pos": 100368284, "end_pos": 100336206, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071450.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071450.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062064.1" } ] } }, { "isoform_ac": "A0ABI0NP37-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL6/entry#A0ABI0NP37-1", "sequence": { "sequence": "MANEGCAKAGDSHFSLDKHAQLILAQINKMRNGEHFCDVELQVGKETFKVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQILLDFIYTGIVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLVKYIEGISDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTVERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGIELCSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGLCVVAVNGLLYVSGGRSSSHDFLAPA", "length": 551, "header": "tr|A0ABI0NP37-1|A0ABI0NP37_BOVIN Computationally mapped isoform of Actin-binding protein IPP OS=Bos taurus OX=9913 GN=IPP PE=4 SV=1 CANONICAL=E1BIL6-1" }, "locus": { "chromosome": "3", "start_pos": 100369805, "end_pos": 100336206, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139350.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139350.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104739.1" } ] } }, { "isoform_ac": "E1BIL6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL6/entry#E1BIL6-1", "sequence": { "sequence": "MANEGCAKAGDSHFSLDKHAQLILAQINKMRNGEHFCDVELQVGKETFKVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQILLDFIYTGIVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLVKYIEGISDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTVERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGIELCSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGLCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584, "header": "tr|E1BIL6-1|E1BIL6_BOVIN Isoform 1 of Actin-binding protein IPP OS=Bos taurus OX=9913 GN=IPP PE=4 SV=2 CANONICAL=E1BIL6-1" }, "locus": { "chromosome": "3", "start_pos": 100368284, "end_pos": 100336206, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031396.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031396.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031351.4", "url": "https://www.ensembl.org/id/ENSBTAP00000031351.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785293", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785293", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JYR6-1", "protein_name": "Actin-binding protein IPP", "gene_name": "Ipp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKEEYAKAADSSFSSDKHAQLILAQMNKMRTGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALFTGGMKESSKDVVQILGVEAGIFQLLLDFIYTGLVNIAVSNVQELIVAADMLQLTEVVNLCCDFLKGQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIRILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKARPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGDTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWIEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZQU9-1", "protein_name": "Intracisternal A particle-promoted polypeptide", "gene_name": "IPP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASEGCAKAGDSPFSSDKHAQLILAQMNKMRNGQHFCDVQLQVGKETFNVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQVLLDFIYTGTVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPQNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKVLRSEELSIEDEYQVFLAAMQWILKDLGRRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVSKSPKENKFCNFLQTSKVRPRKKARKYLYAVGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWIGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 528 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QKS9-1", "protein_name": "Actin-binding protein IPP", "gene_name": "Ipp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSKEECAKAGDSSFSSDKHAELILAQINRMRNGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALFAGGMKESSKDVVQILGIEAGIFQLLLDFIYTGLVNIAVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVSKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVVGGISNEGLELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P28575-1", "protein_name": "Actin-binding protein IPP", "gene_name": "Ipp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKEECPKAADNSFSSDKHAQLILAQMNKMRSGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALFTGGMKESSKDVVQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVVNLCCDFLKGQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVVGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGSMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCAVTVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VK21-1", "protein_name": "Kelch-like protein diablo", "gene_name": "Ipp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPLKTYQIHEYNGNTSPNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALKDDCRDMSVKIALRSICRDIASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV", "length": 627 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y573-1", "protein_name": "Actin-binding protein IPP", "gene_name": "IPP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL", "length": 584 }, "evidence": [ { "id": "E1BIL6", "url": "https://omabrowser.org/oma/group/E1BIL6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BIL6", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIL6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 584, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIL6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIL6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL6" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 104, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 494, "end_pos": 496 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIL7-1", "uniprot_ac": "E1BIL7", "uniprot_id": "E1BIL7_BOVIN", "mass": { "chemical_mass": 63623.0, "monoisotopic_mass": 63623.0 }, "refseq": { "ac": "NP_001192439", "name": "zinc finger protein with KRAB and SCAN domains 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192439" }, "gene_names": [ { "name": "ZKSCAN1", "type": "recommended", "evidence": [ { "id": "E1BIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ] }, { "name": "ZKSCAN1", "type": "synonym", "evidence": [ { "id": "NP_001192439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192439" } ] } ], "protein_names": [ { "name": "Zinc finger protein with KRAB and SCAN domains 1", "type": "recommended", "evidence": [ { "id": "E1BIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIL7/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein with KRAB and SCAN domains 1", "type": "synonym", "evidence": [ { "id": "NP_001192439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192439" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZKSCAN1", "url": "https://www.uniprot.org/uniprotkb/E1BIL7", "locus": { "chromosome": "25", "start_pos": 36404294, "end_pos": 36411525, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016757", "url": "https://www.ensembl.org/id/ENSBTAG00000016757" } ] } } ], "crossref": [ { "id": "E1BIL7", "url": "https://alphafold.ebi.ac.uk/entry/E1BIL7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016757", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016757", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140434", "url": "https://www.ncbi.nlm.nih.gov/gene/100140434", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140434", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140434", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHNRERA", "url": "https://omabrowser.org/oma/group/IHNRERA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIL7", "url": "https://www.orthodb.org/?gene=E1BIL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEEHMWGQDASLQESPPPDPEVFRQRFRHFCYQNTFGPREALSRLKELCHQWLRPEIHTKEQILELLVLEQFLSILPRELQAWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLPHEPTQSHFKHSSRKPRLLQPRALPATHVPAPHPEGAPRDQAMASALFSADSQAMVKIEDMAVSLILEEWGCQNLARRNLNRDTRQENYGNVISQGCENRNENEESTSKAESAEDSASRGETAGKFQKDVGEKREQQGRVVERQQRNPEEKAGKEKRDSGPATVKEKKPSTGERGPREKGKGLGRSFSLSSNFTTTEEVPTGTKAHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHTRERASEYSPASLDTFGAFLKTCV", "length": 563, "header": "tr|E1BIL7-1|E1BIL7_BOVIN Isoform 1 of Zinc finger protein with KRAB and SCAN domains 1 OS=Bos taurus OX=9913 GN=ZKSCAN1 PE=3 SV=1 CANONICAL=E1BIL7-1" }, "isoforms": [ { "isoform_ac": "E1BIL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL7/entry#E1BIL7-1", "sequence": { "sequence": "MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEEHMWGQDASLQESPPPDPEVFRQRFRHFCYQNTFGPREALSRLKELCHQWLRPEIHTKEQILELLVLEQFLSILPRELQAWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLPHEPTQSHFKHSSRKPRLLQPRALPATHVPAPHPEGAPRDQAMASALFSADSQAMVKIEDMAVSLILEEWGCQNLARRNLNRDTRQENYGNVISQGCENRNENEESTSKAESAEDSASRGETAGKFQKDVGEKREQQGRVVERQQRNPEEKAGKEKRDSGPATVKEKKPSTGERGPREKGKGLGRSFSLSSNFTTTEEVPTGTKAHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHTRERASEYSPASLDTFGAFLKTCV", "length": 563, "header": "tr|E1BIL7-1|E1BIL7_BOVIN Isoform 1 of Zinc finger protein with KRAB and SCAN domains 1 OS=Bos taurus OX=9913 GN=ZKSCAN1 PE=3 SV=1 CANONICAL=E1BIL7-1" }, "locus": { "chromosome": "25", "start_pos": 36411445, "end_pos": 36405298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029042.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029042.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029042.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029042.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140434", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140434", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I377-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "Zkscan1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSSVQETPPPDPEVFRQRFRRFCYQNTFGPREALNRLKELCHQWLRPEINSKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDHHEATHSHFKHASRKPRPLPSRALPVTHVPAPHHEGNPRDQAMASALLTADSQAMVKIEDMAVSLILEEWGCQNLARRNLNRDSRQENLGNVFSQGSENRNGKESTSKTDVKEDSTSHGETAGRVQKEFGEKREQQGRVVERTTLFLQRNHEEKTDKEKKEPGPPTTKEKKPTAGERGPREKGKGLGRSFSLSANFNNTSEELPSGAKTHRCDECGKCFTRSSSLIRHKIIHTGEKPYECNECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHARERASEYSPASLDAFGAFLKSCV", "length": 565 }, "evidence": [ { "id": "E1BIL7", "url": "https://omabrowser.org/oma/group/E1BIL7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P17029-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "ZKSCAN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSTLQDTPPPDPEIFRQRFRRFCYQNTFGPREALSRLKELCHQWLRPEINTKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLHHEATQSHFKHSSRKPRLLQSRALPAAHIPAPPHEGSPRDQAMASALFTADSQAMVKIEDMAVSLILEEWGCQNLARRNLSRDNRQENYGSAFPQGGENRNENEESTSKAETSEDSASRGETTGRSQKEFGEKRDQEGKTGERQQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSLSSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHARERASEYSPASLDAFGAFLKSCV", "length": 563 }, "evidence": [ { "id": "E1BIL7", "url": "https://omabrowser.org/oma/group/E1BIL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4KLI1-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "Zkscan1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDASLQETPPPDPEVFRQRFRRFCYQNTFGPREALNRLKELCHQWLRPEVNTKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGVVPLDPVQESSSFDHHEAAQSHFKHSSRKPRLLSPRALPATHVPAPQHEGNPRDQAMASALLTADSQAMVKIEDMAVSLILEEWGCQNLARRNLNRDSRQMNLGTVFSQGSENRNGSESTSKAEVKGDSTSHGEIAGRFQKEFGEKREQQGRVIERQQKNPEEKTGKEKKAPGPPTAKEKKPTTGERGPREKGKGLGRSFSLSANFNNTPEEIPSGAKTHRCDECGKCFTRSSSLIRHKIIHTGEKPYECNECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHARERASEYSPASLDTFGAFLKSCV", "length": 562 }, "evidence": [ { "id": "E1BIL7", "url": "https://omabrowser.org/oma/group/E1BIL7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BGS3-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "Zkscan1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMTAESRETTGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSSLQETPPPDPEVFRQRFRRFCYQNTFGPREALNRLKELCHQWLRPEVNSKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGVVPLDPVQESSSFDHHETAQSHFKHSSRKPRLLSRALPATHVPAPHHEGNPRDQAMASALLTADSQAMVKIEDMAVSLILEEWGCQNLARRNLNRDSRQMNLGNVFSQGSENRNGNESTSKAEVKEDSTSHGEIAGRFQKEFGEKREQQGRVVERQQKNPEEKTGKEKKEPGPPTAKEKKPSTGERGPREKGKGLGRSFSLSANFNNTPEEAPSGAKTHRCDECGKCFTRSSSLIRHKIIHTGEKPYECNECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHARERTSEYSPASLDAFGAFLKSCV", "length": 561 }, "evidence": [ { "id": "E1BIL7", "url": "https://omabrowser.org/oma/group/E1BIL7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BIL7", "url": "https://www.uniprot.org/uniprotkb/E1BIL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIL7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 563, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIL7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIL7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 363, "end_pos": 365 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIN3-1", "uniprot_ac": "E1BIN3", "uniprot_id": "E1BIN3_BOVIN", "mass": { "chemical_mass": 64461.0, "monoisotopic_mass": 64461.0 }, "refseq": { "ac": "XP_002689338", "name": "arylsulfatase I", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689338" }, "gene_names": [ { "name": "ARSI", "type": "recommended", "evidence": [ { "id": "E1BIN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN3" } ] }, { "name": "ARSI", "type": "synonym", "evidence": [ { "id": "XP_002689338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689338" } ] } ], "protein_names": [ { "name": "Arylsulfatase family member I", "type": "synonym", "evidence": [ { "id": "E1BIN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN3/entry#names_and_taxonomy" } ] }, { "name": "arylsulfatase I", "type": "synonym", "evidence": [ { "id": "XP_002689338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689338" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIN3", "url": "https://www.uniprot.org/uniprotkb/E1BIN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARSI", "url": "https://www.uniprot.org/uniprotkb/E1BIN3", "locus": { "chromosome": "7", "start_pos": 61646382, "end_pos": 61653040, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012834", "url": "https://www.ensembl.org/id/ENSBTAG00000012834" } ] } } ], "crossref": [ { "id": "E1BIN3", "url": "https://alphafold.ebi.ac.uk/entry/E1BIN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012834", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16029", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16029", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540390", "url": "https://www.ncbi.nlm.nih.gov/gene/540390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540390", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540390", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDWMKPS", "url": "https://omabrowser.org/oma/group/WDWMKPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIN3", "url": "https://www.orthodb.org/?gene=E1BIN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10342:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10342:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1663150", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1663150", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002689338", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689338", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIN3", "url": "https://www.uniprot.org/uniprotkb/E1BIN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMQALTGFSLVSLLGFGYLSWDWAKPSLVADAPAEAGVEHPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQELGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTLLYAQRVSHILASHSPRQPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRHGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKRRTSRALVHITDWYPTLVALAGGTASAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLAAFPGSWWNLERMASARQAVWLFNISADPYEREDLAGQRPDVVRALLARLVDYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEDEEEEEGRAQSQSRGRRKKKCKICKLRSFFRKLNTRLMSHRI", "length": 574, "header": "tr|E1BIN3-1|E1BIN3_BOVIN Isoform 1 of Arylsulfatase family member I OS=Bos taurus OX=9913 GN=ARSI PE=3 SV=3 CANONICAL=E1BIN3-1" }, "isoforms": [ { "isoform_ac": "E1BIN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN3/entry#E1BIN3-1", "sequence": { "sequence": "MAMQALTGFSLVSLLGFGYLSWDWAKPSLVADAPAEAGVEHPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQELGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTLLYAQRVSHILASHSPRQPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRHGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKRRTSRALVHITDWYPTLVALAGGTASAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLAAFPGSWWNLERMASARQAVWLFNISADPYEREDLAGQRPDVVRALLARLVDYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEDEEEEEGRAQSQSRGRRKKKCKICKLRSFFRKLNTRLMSHRI", "length": 574, "header": "tr|E1BIN3-1|E1BIN3_BOVIN Isoform 1 of Arylsulfatase family member I OS=Bos taurus OX=9913 GN=ARSI PE=3 SV=3 CANONICAL=E1BIN3-1" }, "locus": { "chromosome": "7", "start_pos": 61652841, "end_pos": 61647297, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017050.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017050.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017050.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017050.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540390", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540390", "resource": "KEGG Pathway" }, { "id": "R-BTA-1663150", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1663150", "resource": "Reactome", "description": "The activation of arylsulfatases" }, { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YL20-1", "protein_name": "Arylsulfatase family member I", "gene_name": "ARSI", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVYALTGFSLVSLLSFGYLSWDWMKPGLVADVPTGPMEKSLPPAFARPPHIIFILTDDQGYHDVGYHGSDIQTPTLDRLAAEGVKLENYYIQPICTPSRSQLITGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYKKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGYDLHEGENVAWDQSGKYSTFLYAQRVSKILASHSPKEPIFIYVAFQAVHTPLQSPKEYIYRYRSMGNVARRKYAAMVTCMDEAVKNITWALKKYGYYDNSVIVFSTDNGGQTFSGGSNWPLRGRKGTYWEGGVRGIGFVHSPLIKRKRRTSWALVHITDWYPTLVSLARGNLSNVPGLDGYNVWPAISEGKESPRTEILHNIDPLYNHAKYGSLEDGFGIWNTAVQASIRVGEWKLLTGDPGYSDWIPPQTLTNFPGSWWNLERLTDGLRKSVWLFNITADPYERYDLSEQRPDVVRALLTRLVHYNRTAIPVRYPAENPRAHPDFNGGAWGPWASEDEVEEWEGGGGDPPKSQGKKKKCKICKLRSFFRKLNTRLMSNRI", "length": 574 }, "evidence": [ { "id": "E1BIN3", "url": "https://omabrowser.org/oma/group/E1BIN3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F4Z7-1", "protein_name": "Arylsulfatase I", "gene_name": "arsia", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVRALLALSVLAYLGAADLTQDWTGPNQVEQPNHARPHIIFIMTDDQGFNDIGYHNTDIHTPTLDRLAAAGVKLENYYIQPICTPSRSQFITGRYQIHTGLQHSIIRSRQPSCLPFGLRTLPQRLQEAGYATHMVGKWHLGFYKRDCLPTRRGFNTYFGSLTGSVDYYTYKSCDGPKVCGFDLHDGERVAWGQGGRYSTHLYTQRVRKILAAHDPSSQPLFIFLSFQAVHTPLQSPKEYVYPYRRMGNMFRRKYAGMVSAVDEAVRNVTYALRKYGYYKNTVIFFSTDNGGQPLFGGSNWPLRGRKGTYWEGGVRGIGFVHSPLLRRRRRVSRALIHITDWYPTLMRLAGGNVSQAEGLDGFDMWDTISDGKESPRFEILHNIDPLYNAARHGSLKNGYGIWNTAVQAAVRVGDWKLLTGNPGYGDWIPPQMLGNFPESWWSLERHTEAKKSLWLFNVADDPYERFDLAERRPDVVKQLLARLSFYNRTAVPVRYPSEDPRADPSRNGGAWGPWEGDGENWEPFYIKKKKAKKQKRKFCKMKSFFRRLNIRIMSNRI", "length": 558 }, "evidence": [ { "id": "E1BIN3", "url": "https://omabrowser.org/oma/group/E1BIN3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q32KI9-1", "protein_name": "Arylsulfatase I", "gene_name": "Arsi", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAGDQPSVAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHNPQNPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGGAWGPWASEEEEEEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSHRI", "length": 573 }, "evidence": [ { "id": "E1BIN3", "url": "https://omabrowser.org/oma/group/E1BIN3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q32KJ8-1", "protein_name": "Arylsulfatase I", "gene_name": "Arsi", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAEDQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHSPQKPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVWLFNISADPYEREDLADQRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGGAWGPWASDEDEEEEDEEEEGRARSFPRGRRKKKCKICKLRSFFRKLNTRLMSHRI", "length": 573 }, "evidence": [ { "id": "E1BIN3", "url": "https://omabrowser.org/oma/group/E1BIN3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5FYB1-1", "protein_name": "Arylsulfatase I", "gene_name": "ARSI", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI", "length": 569 }, "evidence": [ { "id": "E1BIN3", "url": "https://omabrowser.org/oma/group/E1BIN3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BIN3", "url": "https://www.uniprot.org/uniprotkb/E1BIN3" } ], "pmid": "" }, { "name": "sulfuric ester hydrolase activity", "id": "GO:0008484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008484", "evidence": [ { "database": "UniProtKB", "id": "E1BIN3", "url": "https://www.uniprot.org/uniprotkb/E1BIN3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 499, "end_pos": 501, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIN3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 574, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIN3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIN3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN3" }, { "id": "PF00884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfatase N-terminal", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 362, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 279, "end_pos": 281 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 469, "end_pos": 471 }, { "start_pos": 499, "end_pos": 501 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIN6-1", "uniprot_ac": "E1BIN6", "uniprot_id": "E1BIN6_BOVIN", "mass": { "chemical_mass": 39135.0, "monoisotopic_mass": 39135.0 }, "refseq": { "ac": "XP_002688407", "name": "cyclin-G2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688407" }, "gene_names": [ { "name": "CCNG2", "type": "recommended", "evidence": [ { "id": "E1BIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ] }, { "name": "CCNG2", "type": "synonym", "evidence": [ { "id": "XP_002688407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688407" } ] } ], "protein_names": [ { "name": "Cyclin-G1", "type": "recommended", "evidence": [ { "id": "E1BIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN6/entry#names_and_taxonomy" } ] }, { "name": "Cyclin-G2", "type": "synonym", "evidence": [ { "id": "E1BIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN6/entry#names_and_taxonomy" } ] }, { "name": "cyclin-G2", "type": "synonym", "evidence": [ { "id": "XP_002688407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688407" } ] } ], "function": [ { "annotation": "May play a role in growth regulation and in negative regulation of cell cycle progression.", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6#function" }, { "database": "UniProtKB", "id": "ARBA00058130", "url": "https://www.uniprot.org/uniprotkb/ARBA00058130#function" }, { "database": "UniProtKB", "id": "A0AAA9SB10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB10#function" } ] }, { "annotation": "May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6#function" }, { "database": "UniProtKB", "id": "ARBA00025528", "url": "https://www.uniprot.org/uniprotkb/ARBA00025528#function" }, { "database": "UniProtKB", "id": "A0AAA9SB10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB10#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNG2", "url": "https://www.uniprot.org/uniprotkb/E1BIN6", "locus": { "chromosome": "6", "start_pos": 92003021, "end_pos": 91993020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021768", "url": "https://www.ensembl.org/id/ENSBTAG00000021768" } ] } } ], "crossref": [ { "id": "E1BIN6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021768", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021768", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20584", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20584", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512960", "url": "https://www.ncbi.nlm.nih.gov/gene/512960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEWKYQP", "url": "https://omabrowser.org/oma/group/QEWKYQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIN6", "url": "https://www.orthodb.org/?gene=E1BIN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688407", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688407", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDLGAEYLAGREGVQLFGLLNLYLEQEQRFQPREKGLSLIEATPETDNTLCPRLRNAKVEDLRSLTNFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARIVEEECNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYEFEATTALNFLHLYHTIVLCHTSERKEILSLDKLEAQLKACCCRLTFSKAKPSILALCLLNLEVETLKSIELLEILLLVKKHSKVNDSEFVYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPHRDQECTFFFSFKVAQTLCFPS", "length": 344, "header": "tr|E1BIN6-1|E1BIN6_BOVIN Isoform 1 of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG2 PE=3 SV=2 CANONICAL=E1BIN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB10-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN6/entry#A0AAA9SB10-1", "sequence": { "sequence": "MRNPDLRVTKAPKAERGARYGNNQSEGPRANQLANRDSRLNRSFSILLAPPVSNQGTGYFGRTFQNSENKTNRGPLKMKDLGAEYLAGREGVQLFGLLNLYLEQEQRFQPREKGLSLIEATPETDNTLCPRLRNAKVEDLRSLTNFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARIVEEECNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYEFEATTALNFLHLYHTIVLCHTSERKEILSLDKLEAQLKACCCRLTFSKAKPSILALCLLNLEVETLKSIELLEILLLVKKHSKVNDSEFVYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPHRDQECTFFFSFKVAQTLCFPS", "length": 421, "header": "tr|A0AAA9SB10-1|A0AAA9SB10_BOVIN Computationally mapped isoform of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG2 PE=3 SV=1 CANONICAL=E1BIN6-1" }, "locus": { "chromosome": "6", "start_pos": 92001706, "end_pos": 91993038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128750.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128750.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081088.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081088.1" } ] } }, { "isoform_ac": "E1BIN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN6/entry#E1BIN6-1", "sequence": { "sequence": "MKDLGAEYLAGREGVQLFGLLNLYLEQEQRFQPREKGLSLIEATPETDNTLCPRLRNAKVEDLRSLTNFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARIVEEECNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYEFEATTALNFLHLYHTIVLCHTSERKEILSLDKLEAQLKACCCRLTFSKAKPSILALCLLNLEVETLKSIELLEILLLVKKHSKVNDSEFVYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPHRDQECTFFFSFKVAQTLCFPS", "length": 344, "header": "tr|E1BIN6-1|E1BIN6_BOVIN Isoform 1 of Cyclin-G1 OS=Bos taurus OX=9913 GN=CCNG2 PE=3 SV=2 CANONICAL=E1BIN6-1" }, "locus": { "chromosome": "6", "start_pos": 92001706, "end_pos": 91994856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029017.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029017.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029017.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029017.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512960", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A578-1", "protein_name": "Cyclin-G1", "gene_name": "CCNG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKDLGAEYLAGREGVQLLGLLNLYLEQEQRFQPREKGLSLIEATPENDNSLCSRLRNAKVEDLRSLTNFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARIVEEECNIPSTHDVIRISQCKCTASDINRMEKIISEKLHYELEATTALNFLHLYHTIVLCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSILALCLLNLEVETLKSIELLEILLLVKKHSKINDSEFIYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSGCPHSNPECAFFFSFKVAQTLCVPS", "length": 344 }, "evidence": [ { "id": "E1BIN6", "url": "https://omabrowser.org/oma/group/E1BIN6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7INE3-1", "protein_name": "Cyclin-G2", "gene_name": "Ccng2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKDLGAEHLAGGEGVQLLGLLNFYLEQEQRFQPREKGLSLMEDTPENDNTLCSRLRNAKVEDLRSLTNFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARMVEEECNVPPTHDVIRISQCKCTASDIERMEKIISEKLHYELEATTALNFLHLYHAIVFCHTSERKEILSLDKLEAQLKACSCRLVFSKAKPSVLALCLLNLEIETIKSVELLEILLLVKKHLKISDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDGSESEDSCEDMSCGEDSLSSSPPSDQECTFFFDFKVAQTLCFPS", "length": 344 }, "evidence": [ { "id": "E1BIN6", "url": "https://omabrowser.org/oma/group/E1BIN6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y1D7-1", "protein_name": "Cyclin-G2", "gene_name": "CCNG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGSEALRLFRQLNLHLELEGRFQPRERGLSLIECAAENENALCPRQRNAKVEDLWSLTNFFGFATETFVLAVNILDRFLALMKVKPKHLSCIGVCCFQLAAQVVEEECNIPSAHEIIRISQCKCTVSDLKRMEKIISEKLHFEFKATTALTFLHLYHTIVLCHTSERKEVLNLDKLEAQLKACNCRLVFSKAKPSVLALCLLTLEVQSLKSVELFEILLRVQKHSKISDCDLLYWRELVSKCLADYSSPECCKPDHKKLVWIVSRRTAQNLQNSYYSVPELPTIPEGGCFNESERWKCSTSDLQLPEPRWSQSLQIARPVTILLAQRPLGTDLQKHKEAPRNRAAETRRGQDSCCVCPFTATDGI", "length": 365 }, "evidence": [ { "id": "E1BIN6", "url": "https://omabrowser.org/oma/group/E1BIN6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O08918-1", "protein_name": "Cyclin-G2", "gene_name": "Ccng2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKDLGAKHLAGGEGVQLFGLLNFYLEQEQRYQPREKGLILMEATPENDNTLCSRLRNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHAIVFCHTSERKEILSLDKLEAQLKACNCRVVFSKARPSVLALCLLNLEIETIKSVELLEILLLVKKHLKLSDTEFFYWRELVSKCLAEYSSPRCCKPDLKKLVWIVSRRTAQNLHSSYYSVPELPTIPEGGCFDGSESEDSGEDMSCGEESLSSSPPSDQECTFFFDFQVAQTLCFPP", "length": 344 }, "evidence": [ { "id": "E1BIN6", "url": "https://omabrowser.org/oma/group/E1BIN6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16589-1", "protein_name": "Cyclin-G2", "gene_name": "CCNG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETLKSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS", "length": 344 }, "evidence": [ { "id": "E1BIN6", "url": "https://omabrowser.org/oma/group/E1BIN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "E1BIN6", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIN6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 344, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIN6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIN6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIN6" }, { "id": "SM00385", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00385" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-like", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 147, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIP6-1", "uniprot_ac": "E1BIP6", "uniprot_id": "E1BIP6_BOVIN", "mass": { "chemical_mass": 12866.0, "monoisotopic_mass": 12866.0 }, "refseq": { "ac": "XP_059744679", "name": "glutaredoxin-like protein C5orf63 homolog isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744679" }, "gene_names": [ { "name": "C7H5orf63", "type": "recommended", "evidence": [ { "id": "E1BIP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP6" } ] }, { "name": "C7H5orf63", "type": "synonym", "evidence": [ { "id": "XP_059744679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744679" } ] } ], "protein_names": [ { "name": "Glutaredoxin-like protein", "type": "recommended", "evidence": [ { "id": "E1BIP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP6/entry#names_and_taxonomy" } ] }, { "name": "glutaredoxin-like protein C5orf63 homolog isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059744679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744679" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIP6", "url": "https://www.uniprot.org/uniprotkb/E1BIP6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C7H5orf63", "url": "https://www.uniprot.org/uniprotkb/E1BIP6", "locus": { "chromosome": "7", "start_pos": 26922493, "end_pos": 26898997, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017835", "url": "https://www.ensembl.org/id/ENSBTAG00000017835" } ] } } ], "crossref": [ { "id": "E1BIP6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIP6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017835", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017835", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100335582", "url": "https://www.ncbi.nlm.nih.gov/gene/100335582", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100335582", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100335582", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR33558", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33558", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33558:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33558:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05768", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05768", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744679", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NWT1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWT1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NX98", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NX98-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP6", "url": "https://www.uniprot.org/uniprotkb/E1BIP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWFQGNSMQLAKHSFLLLLRNLSASKTALPVLTLFTKDPCPLCDEAKEVLEPYRNREVDITLPENSAWYDRYKFDIPVFHLNGQFLMMHRVNLSKLEKQLQKLEQQGAGG", "length": 111, "header": "tr|E1BIP6-1|E1BIP6_BOVIN Isoform 1 of Glutaredoxin-like protein OS=Bos taurus OX=9913 GN=C7H5orf63 PE=3 SV=4 CANONICAL=E1BIP6-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NWT1-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP6/entry#A0ABI0NWT1-1", "sequence": { "sequence": "MLWFQGNSMQLAKHSFLLLLRNLSASKTALPVLTLFTKDPCPLCDEAKEVLEPYRNRVI", "length": 59, "header": "tr|A0ABI0NWT1-1|A0ABI0NWT1_BOVIN Computationally mapped isoform of Glutaredoxin-like protein OS=Bos taurus OX=9913 GN=C7H5orf63 PE=3 SV=1 CANONICAL=E1BIP6-1" }, "locus": { "chromosome": "7", "start_pos": 26921200, "end_pos": 26916117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144027.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144027.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104333.1" } ] } }, { "isoform_ac": "A0ABI0NX98-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP6/entry#A0ABI0NX98-1", "sequence": { "sequence": "MLWFQGNSMQLAKHSFLLLLRNLSASKTALPVLTLFTKDPCPLCDEAKEVLEPYRNRFILQEVDITLPENSAWYDSSRSLSSKVQEADKHPHDFLPSLSRTCFPEEMTVSSNSFCHFRTALQMF", "length": 124, "header": "tr|A0ABI0NX98-1|A0ABI0NX98_BOVIN Computationally mapped isoform of Glutaredoxin-like protein OS=Bos taurus OX=9913 GN=C7H5orf63 PE=3 SV=1 CANONICAL=E1BIP6-1" }, "locus": { "chromosome": "7", "start_pos": 26922147, "end_pos": 26916117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140555.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140555.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105397.1" } ] } }, { "isoform_ac": "E1BIP6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP6/entry#E1BIP6-1", "sequence": { "sequence": "MLWFQGNSMQLAKHSFLLLLRNLSASKTALPVLTLFTKDPCPLCDEAKEVLEPYRNREVDITLPENSAWYDRYKFDIPVFHLNGQFLMMHRVNLSKLEKQLQKLEQQGAGG", "length": 111, "header": "tr|E1BIP6-1|E1BIP6_BOVIN Isoform 1 of Glutaredoxin-like protein OS=Bos taurus OX=9913 GN=C7H5orf63 PE=3 SV=4 CANONICAL=E1BIP6-1" }, "locus": { "chromosome": "7", "start_pos": 26922035, "end_pos": 26916117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023708.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023708.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023707.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023707.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100335582", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100335582", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIP6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 111, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIP6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIP6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIR4-1", "uniprot_ac": "E1BIR4", "uniprot_id": "E1BIR4_BOVIN", "mass": { "chemical_mass": 68441.0, "monoisotopic_mass": 68441.0 }, "refseq": { "ac": "XP_024856977", "name": "cyclic nucleotide-binding domain-containing protein 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856977" }, "gene_names": [ { "name": "CNBD2", "type": "recommended", "evidence": [ { "id": "E1BIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ] }, { "name": "CNBD2", "type": "synonym", "evidence": [ { "id": "XP_024856977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856977" } ] } ], "protein_names": [ { "name": "Cyclic nucleotide-binding domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "E1BIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR4/entry#names_and_taxonomy" } ] }, { "name": "cyclic nucleotide-binding domain-containing protein 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024856977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856977" } ] } ], "function": [ { "annotation": "Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M9D3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9D3#function" }, { "database": "UniProtKB", "id": "ARBA00059651", "url": "https://www.uniprot.org/uniprotkb/ARBA00059651#function" }, { "database": "UniProtKB", "id": "A0AAA9T699", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T699#function" }, { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNBD2", "url": "https://www.uniprot.org/uniprotkb/E1BIR4", "locus": { "chromosome": "13", "start_pos": 65148798, "end_pos": 65086337, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002822", "url": "https://www.ensembl.org/id/ENSBTAG00000002822" } ] } } ], "crossref": [ { "id": "E1BIR4", "url": "https://alphafold.ebi.ac.uk/entry/E1BIR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002822", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002822", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517009", "url": "https://www.ncbi.nlm.nih.gov/gene/517009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517009", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517009", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M9D3", "url": "https://www.orthodb.org/?gene=A0A3Q1M9D3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIR4", "url": "https://www.orthodb.org/?gene=E1BIR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23011:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23011:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9D3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9D3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T699", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T699", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T699-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T699-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIR4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRYMVSRSWQILRKKLGLYHLSMDIIMMNRVCKMFRQGLRGFREYQIIETAHRKHPIFSFWDKKKEGRITFDTMDFVAESGHFPPRAIQITQKQPAWRAEHEIQSLCNLLQVLDSYRNYSEPLQLLLAKVMRFERFGRRRVIVKKGQRGNSFYFIYLGTVAVTEDEDGSSAFLDPHPTLLQKGSCFGEMGSLSSTVRRATVVCMEETEFLVVDREDFLANKLDQEVKKDAQLRFEFFRKMDLFHSWSDETLWKLVVLGKVEKFSYGQLISKDFIESSSIMFVCEGICEVLRLIDLESSPFYHKWIWEHLQLIDDGPPNIHLKDLSPVERFKEFQIRSYPVQDFSFLKLFHLQKAQEQEGSSFSRKIKTSGNTLPKTFGSKIKSRCSHLIKCPMIQTKYGDLPKEAAVGAYMKIHTVEQGEILGLHQILLPESQHDTRPLILVSLGAEVIRIRKEKFCELLDSNTIEKLSKFSIKYPSDEDLCQRFLKENNWNIFRKDLVRLLVEPRWRPAFTPIQPKKKGTYNPRIVMLDLYSLDKKTKRRHPIFMAPQKYLPPLRIVQTIIAPRYKIQELLPQYKNAGVLM", "length": 583, "header": "tr|E1BIR4-1|E1BIR4_BOVIN Isoform 1 of Cyclic nucleotide-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=CNBD2 PE=4 SV=3 CANONICAL=E1BIR4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9D3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR4/entry#A0A3Q1M9D3-1", "sequence": { "sequence": "MNRYMVSRSWQILRKKLGLYHLSMDIIMMNRVCKMFRQGLRGFREYQIIETAHRKHPIFSFWDKKKEGRITFDTMDFVAESGHFPPRAIQITQKQPAWRAEHEIQSLCNLLQVLDSYRNYSEPLQLLLAKVMRFERFGRRRVIVKKGQRGNSFYFIYLGTVAVTEDEDGSSAFLDPHPTLLQKGSCFGEMGSLSSTVRRATVVCMEETEFLVVDREDFLANKLDQEVKKDAQLRFEFFRKMDLFHSWSDETLWKLVVLGKVEKFSYGQLISKDFIESSSIMFVCEGICEVLRLIDLESSPFYHKWIWEHLQLIDDGPPNIHLKDLSPVERFKEFQIRSYPVQDFSFLKLFHLQKAQEQEGSSFSRKIKTSGNTLPKTFGSKIKSRCSHLIKCPMIQTKYGDLPKEAAVGAYMKIHTVEQGEILR", "length": 424, "header": "tr|A0A3Q1M9D3-1|A0A3Q1M9D3_BOVIN Computationally mapped isoform of Cyclic nucleotide-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=CNBD2 PE=4 SV=2 CANONICAL=E1BIR4-1" }, "locus": { "chromosome": "13", "start_pos": 65148337, "end_pos": 65100388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075489.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075489.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065051.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065051.2" } ] } }, { "isoform_ac": "A0AAA9T699-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR4/entry#A0AAA9T699-1", "sequence": { "sequence": "MMSSAHRSPEAGSGLPEAAPPRVRTSGLEVAGPAGLQTNLSSPRLAPDGGALEDVFEEKSEEEESEEEEEEEPEEGSEEEQVPKPPPKPEEARKSVLARLDRFSLQVNKSRYQEAKDWFKIKNLGLYHLSMDIIMMNRVCKMFRQGLRGFREYQIIETAHRKHPIFSFWDKKKEGRITFDTMDFVAESGHFPPRAIQITQKQPAWRAEHEIQSLCNLLQVLDSYRNYSEPLQLLLAKVMRFERFGRRRVIVKKGQRGNSFYFIYLGTVAVTEDEDGSSAFLDPHPTLLQKGSCFGEMGSLSSTVRRATVVCMEETEFLVVDREDFLANKLDQEVKKDAQLRFEFFRKMDLFHSWSDETLWKLVVLGKVEKFSYGQLISKDFIESSSIMFVCEGICEVLRLIDLESSPFYHKWIWEHLQLIDDGPPNIHLKDLSPVERFKEFQIRSYPVQDFSFLKLFHLQKAQEQEGSSFSRKIKTSGNTLPKTFGSKIKSRCSHLIKCPMIQTKYGDLPKEAAVGAYMKIHTVEQGEILGLHQILLPESQHDTRPLILVSLGAEVIRIRKEKFCELLDSNTIEKLSKFSIKYPSDEDLCQRFLKENNWNIFRKDLVRLLVEPRWRPAFTPIQPKKKGTYNPRIVMLDLYSLDKKTKRRHPIFMAPQKYLPPLRIVQTIIAPRYKIQELLPQYKNAGVLM", "length": 690, "header": "tr|A0AAA9T699-1|A0AAA9T699_BOVIN Computationally mapped isoform of Cyclic nucleotide-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=CNBD2 PE=4 SV=1 CANONICAL=E1BIR4-1" }, "locus": { "chromosome": "13", "start_pos": 65148650, "end_pos": 65086536, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099380.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099380.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093401.1" } ] } }, { "isoform_ac": "E1BIR4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR4/entry#E1BIR4-1", "sequence": { "sequence": "MNRYMVSRSWQILRKKLGLYHLSMDIIMMNRVCKMFRQGLRGFREYQIIETAHRKHPIFSFWDKKKEGRITFDTMDFVAESGHFPPRAIQITQKQPAWRAEHEIQSLCNLLQVLDSYRNYSEPLQLLLAKVMRFERFGRRRVIVKKGQRGNSFYFIYLGTVAVTEDEDGSSAFLDPHPTLLQKGSCFGEMGSLSSTVRRATVVCMEETEFLVVDREDFLANKLDQEVKKDAQLRFEFFRKMDLFHSWSDETLWKLVVLGKVEKFSYGQLISKDFIESSSIMFVCEGICEVLRLIDLESSPFYHKWIWEHLQLIDDGPPNIHLKDLSPVERFKEFQIRSYPVQDFSFLKLFHLQKAQEQEGSSFSRKIKTSGNTLPKTFGSKIKSRCSHLIKCPMIQTKYGDLPKEAAVGAYMKIHTVEQGEILGLHQILLPESQHDTRPLILVSLGAEVIRIRKEKFCELLDSNTIEKLSKFSIKYPSDEDLCQRFLKENNWNIFRKDLVRLLVEPRWRPAFTPIQPKKKGTYNPRIVMLDLYSLDKKTKRRHPIFMAPQKYLPPLRIVQTIIAPRYKIQELLPQYKNAGVLM", "length": 583, "header": "tr|E1BIR4-1|E1BIR4_BOVIN Isoform 1 of Cyclic nucleotide-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=CNBD2 PE=4 SV=3 CANONICAL=E1BIR4-1" }, "locus": { "chromosome": "13", "start_pos": 65148650, "end_pos": 65100388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003652.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003652.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003652.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003652.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517009", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517009", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cAMP binding", "id": "GO:0030552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030552", "evidence": [ { "database": "UniProtKB", "id": "E1BIR4", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIR4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 583, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIR4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIR4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR4" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 218, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIR7-1", "uniprot_ac": "E1BIR7", "uniprot_id": "E1BIR7_BOVIN", "mass": { "chemical_mass": 26469.0, "monoisotopic_mass": 26469.0 }, "refseq": { "ac": "NP_001192791", "name": "C1q-related factor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192791" }, "gene_names": [ { "name": "C1QL1", "type": "recommended", "evidence": [ { "id": "E1BIR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ] }, { "name": "C1QL1", "type": "synonym", "evidence": [ { "id": "NP_001192791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192791" } ] } ], "protein_names": [ { "name": "C1q-related factor precursor", "type": "synonym", "evidence": [ { "id": "NP_001192791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192791" } ] }, { "name": "Complement C1q like 1", "type": "synonym", "evidence": [ { "id": "E1BIR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1QL1", "url": "https://www.uniprot.org/uniprotkb/E1BIR7", "locus": { "chromosome": "19", "start_pos": 44655692, "end_pos": 44665394, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011759", "url": "https://www.ensembl.org/id/ENSBTAG00000011759" } ] } } ], "crossref": [ { "id": "E1BIR7", "url": "https://alphafold.ebi.ac.uk/entry/E1BIR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011759", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011759", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519675", "url": "https://www.ncbi.nlm.nih.gov/gene/519675", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519675", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519675", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYDGIAG", "url": "https://omabrowser.org/oma/group/NYDGIAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIR7", "url": "https://www.orthodb.org/?gene=E1BIR7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22923", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22923", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22923:SF64", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22923:SF64", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192791", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T646", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T646", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T646-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T646-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIR7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARPDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKTGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDATSGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258, "header": "tr|E1BIR7-1|E1BIR7_BOVIN Isoform 1 of Complement C1q like 1 OS=Bos taurus OX=9913 GN=C1QL1 PE=4 SV=1 CANONICAL=E1BIR7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T646-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR7/entry#A0AAA9T646-1", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARPDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKTGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDATSGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKEPGVSSSASCLGSISPIRQGLPKGKVYFCTPQTWPT", "length": 282, "header": "tr|A0AAA9T646-1|A0AAA9T646_BOVIN Computationally mapped isoform of Complement C1q like 1 OS=Bos taurus OX=9913 GN=C1QL1 PE=4 SV=1 CANONICAL=E1BIR7-1" }, "locus": { "chromosome": "19", "start_pos": 44665116, "end_pos": 44655737, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127565.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127565.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093336.1" } ] } }, { "isoform_ac": "A0AAA9TWS5-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR7/entry#A0AAA9TWS5-1", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARPDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKTGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDATSGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNNPPGYDAPGPSSPPSGPQLALPPAHRRAGSSAPCPRSSGGGVDRPRPGPCCIFVQ", "length": 300, "header": "tr|A0AAA9TWS5-1|A0AAA9TWS5_BOVIN Computationally mapped isoform of Complement C1q like 1 OS=Bos taurus OX=9913 GN=C1QL1 PE=4 SV=1 CANONICAL=E1BIR7-1" }, "locus": { "chromosome": "19", "start_pos": 44665116, "end_pos": 44658249, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094456.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094456.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101630.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101630.1" } ] } }, { "isoform_ac": "E1BIR7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIR7/entry#E1BIR7-1", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARPDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKTGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDATSGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258, "header": "tr|E1BIR7-1|E1BIR7_BOVIN Isoform 1 of Complement C1q like 1 OS=Bos taurus OX=9913 GN=C1QL1 PE=4 SV=1 CANONICAL=E1BIR7-1" }, "locus": { "chromosome": "19", "start_pos": 44665116, "end_pos": 44658495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015618.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015618.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015618.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015618.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519675", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519675", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B5M8-1", "protein_name": "Complement C1q like 1", "gene_name": "C1QL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLVLVVLIPVLVSSGSPDGHYEMLGTCRMVCDPYPARGPGAGARPDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKTGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDATSGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258 }, "evidence": [ { "id": "E1BIR7", "url": "https://omabrowser.org/oma/group/E1BIR7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZEN8-1", "protein_name": "Complement C1q like 1", "gene_name": "C1ql1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARSDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDRGPPGPVGPPGEKGEPGKPGPPGLPGSGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDAASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258 }, "evidence": [ { "id": "E1BIR7", "url": "https://omabrowser.org/oma/group/E1BIR7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75973-1", "protein_name": "C1q-related factor", "gene_name": "C1QL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPEGHYEMLGTCRMVCDPYPARGPGAGARTDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKPGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDAASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258 }, "evidence": [ { "id": "E1BIR7", "url": "https://omabrowser.org/oma/group/E1BIR7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88992-1", "protein_name": "C1q-related factor", "gene_name": "C1ql1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLVLVVLIPVLVSSGGPDGHYEMLGTCRMVCDPYPARGPGAGARSDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDRGPPGPVGPPGEKGEPGKPGPPGLPGSGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDAASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD", "length": 258 }, "evidence": [ { "id": "E1BIR7", "url": "https://omabrowser.org/oma/group/E1BIR7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "climbing fiber", "id": "GO:0044301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044301", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "cerebellar climbing fiber to Purkinje cell synapse", "id": "GO:0150053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150053", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "maintenance of synapse structure", "id": "GO:0099558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099558", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "trans-synaptic signaling, modulating synaptic transmission", "id": "GO:0099550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099550", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" }, { "name": "regulation of synapse pruning", "id": "GO:1905806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905806", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "E1BIR7", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIR7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIR7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIR7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIR7" }, { "id": "PS50871", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50871" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 258, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIU5-1", "uniprot_ac": "E1BIU5", "uniprot_id": "E1BIU5_BOVIN", "mass": { "chemical_mass": 77535.0, "monoisotopic_mass": 77535.0 }, "refseq": { "ac": "XP_003585852", "name": "F-box only protein 42", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585852" }, "gene_names": [ { "name": "FBXO42", "type": "recommended", "evidence": [ { "id": "E1BIU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU5" } ] }, { "name": "FBXO42", "type": "synonym", "evidence": [ { "id": "XP_003585852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585852" } ] } ], "protein_names": [ { "name": "F-box only protein 42", "type": "synonym", "evidence": [ { "id": "XP_003585852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585852" } ] }, { "name": "F-box protein 42", "type": "synonym", "evidence": [ { "id": "E1BIU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIU5", "url": "https://www.uniprot.org/uniprotkb/E1BIU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO42", "url": "https://www.uniprot.org/uniprotkb/E1BIU5", "locus": { "chromosome": "2", "start_pos": 135864767, "end_pos": 135783583, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008510", "url": "https://www.ensembl.org/id/ENSBTAG00000008510" } ] } } ], "crossref": [ { "id": "E1BIU5", "url": "https://alphafold.ebi.ac.uk/entry/E1BIU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848477", "url": "https://www.ncbi.nlm.nih.gov/gene/100848477", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848477", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848477", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWLLHIH", "url": "https://omabrowser.org/oma/group/AWLLHIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIU5", "url": "https://www.orthodb.org/?gene=E1BIU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46432", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46432", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46432:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46432:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003585852", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIU5", "url": "https://www.uniprot.org/uniprotkb/E1BIU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BIU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSSDSEDDSFMAVDQEETVLEGTMEQDEEPRAALEVVEMQHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFIKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSSDVWVLDLEQWAWSKPSISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPVLNGGSLSPGSAAVSGSSLDSPVQAVSPSTPSTTEGYDLKMGLSLAPRRGSLPDQKDLRLGSIDLNWDLKAASSGNHVDGVGSRTAGGSLRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPPASAALSPPLGSSPGSPGSQNLGSGEAVPVPRPGPAQGDGHALPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVRGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717, "header": "tr|E1BIU5-1|E1BIU5_BOVIN Isoform 1 of F-box protein 42 OS=Bos taurus OX=9913 GN=FBXO42 PE=4 SV=1 CANONICAL=E1BIU5-1" }, "isoforms": [ { "isoform_ac": "E1BIU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BIU5/entry#E1BIU5-1", "sequence": { "sequence": "MASSSDSEDDSFMAVDQEETVLEGTMEQDEEPRAALEVVEMQHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFIKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSSDVWVLDLEQWAWSKPSISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPVLNGGSLSPGSAAVSGSSLDSPVQAVSPSTPSTTEGYDLKMGLSLAPRRGSLPDQKDLRLGSIDLNWDLKAASSGNHVDGVGSRTAGGSLRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPPASAALSPPLGSSPGSPGSQNLGSGEAVPVPRPGPAQGDGHALPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVRGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717, "header": "tr|E1BIU5-1|E1BIU5_BOVIN Isoform 1 of F-box protein 42 OS=Bos taurus OX=9913 GN=FBXO42 PE=4 SV=1 CANONICAL=E1BIU5-1" }, "locus": { "chromosome": "2", "start_pos": 135863763, "end_pos": 135815897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011217.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011217.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011217.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011217.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 378, "start_aa": "Thr", "end_pos": 378, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr378", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 467, "start_aa": "Thr", "end_pos": 467, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr467", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100848477", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848477", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MKA4-1", "protein_name": "F-box only protein 42", "gene_name": "Fbxo42", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSSDSEDDSFMAVDQEETVLEGTMEQEEESHPVLEVEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIGDKMIVFGGSLGSRQMSNEVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHPGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGTLSPGTAAVGGASLDSPVQVVSPSTPSASEGYDLKMGLSLAPRRGSLPDQKDLRLSSIDLNWDLKSASNSSHVDGTDNRTVAGSVRHPPEQTNGVHTPPHVASALAGAVSPSALRRSLEAIKAMSSKGPSASATLSPPLGSSPSSPGNQNLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFTSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717 }, "evidence": [ { "id": "E1BIU5", "url": "https://omabrowser.org/oma/group/E1BIU5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AE47-1", "protein_name": "F-box protein 42", "gene_name": "Fbxo42", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVSWPWTKKKLHWKGQWSKMRTHTQYWRLRKQDIIGPCLSCQKRFWSISCPSSHHIRNTKPQLWSASSGIGLSKVQVFQRGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIGDKMIVFGGSLGSRQMSNEVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHPGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGNLSPGTAAVGGASLDSPVQVVSPSTPSASDGYDLKVGLSLVPRRGSLPDQKDLRLSSIDVNWDLKSASTSSRVDSTDSRTVAGSVRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPSSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFTSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 715 }, "evidence": [ { "id": "E1BIU5", "url": "https://omabrowser.org/oma/group/E1BIU5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SUS5-1", "protein_name": "F-box protein 42", "gene_name": "FBXO42", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASSSDSEDDSFMAVDQEETVLEGTMEQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFIKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRNMDEAPCVNGRWGTLRPRAQRQTPSSSREGSLSPARGDGSPILNGGSLSPGSAAVGGSSLDSPVQAISPSTPSTTEGYDLKMGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASTSNHMDGVDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPSALRRSLEAIKAMSSKGPPASAALSPPLGSSPGSPGSQNLSSGETVPVPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717 }, "evidence": [ { "id": "E1BIU5", "url": "https://omabrowser.org/oma/group/E1BIU5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6P3S6-1", "protein_name": "F-box only protein 42", "gene_name": "FBXO42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717 }, "evidence": [ { "id": "E1BIU5", "url": "https://omabrowser.org/oma/group/E1BIU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PDJ6-1", "protein_name": "F-box only protein 42", "gene_name": "Fbxo42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSSDSEDDSVMAVDQEETALEGTMEQDEDPHPVLEVEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIGDKMIVFGGSLGSRQMSNEVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDTTLLILGGCGGPNALFKDAWLLHMHPGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGNLSPGTVAVGGASLDSPVQVVSPSTPSASDGYDLKVGLSLAPRRGSLPDQKDLRLSSIDLNWDLKSASSSSHVDSIDNRTVAGSVRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPSSPGSQSLSSGETVPNSRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFTSSSVVGPPETSLHTVVQGRGELIVFGGLMDKKQNVKYYPKTNALYFVRAKR", "length": 717 }, "evidence": [ { "id": "E1BIU5", "url": "https://omabrowser.org/oma/group/E1BIU5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "E1BIU5", "url": "https://www.uniprot.org/uniprotkb/E1BIU5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BIU5", "url": "https://www.uniprot.org/uniprotkb/E1BIU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 717, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIU5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU5" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 93, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 378, 467 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 666, "end_pos": 668 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIV7-1", "uniprot_ac": "E1BIV7", "uniprot_id": "E1BIV7_BOVIN", "mass": { "chemical_mass": 226045.0, "monoisotopic_mass": 226045.0 }, "refseq": { "ac": "XP_003586079", "name": "zinc finger C3H1 domain-containing protein isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586079" }, "gene_names": [ { "name": "ZFC3H1", "type": "recommended", "evidence": [ { "id": "E1BIV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" } ] }, { "name": "ZFC3H1", "type": "synonym", "evidence": [ { "id": "XP_003586079", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586079" } ] } ], "protein_names": [ { "name": "Zinc finger C3H1-type containing", "type": "synonym", "evidence": [ { "id": "E1BIV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV7/entry#names_and_taxonomy" } ] }, { "name": "zinc finger C3H1 domain-containing protein isoform X3", "type": "synonym", "evidence": [ { "id": "XP_003586079", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586079" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIV7", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFC3H1", "url": "https://www.uniprot.org/uniprotkb/E1BIV7", "locus": { "chromosome": "5", "start_pos": 1243416, "end_pos": 1294900, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012267", "url": "https://www.ensembl.org/id/ENSBTAG00000012267" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012267", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012267", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781886", "url": "https://www.ncbi.nlm.nih.gov/gene/781886", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003107", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003107", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781886", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781886", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKENFDD", "url": "https://omabrowser.org/oma/group/CKENFDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTW3", "url": "https://www.orthodb.org/?gene=A0A3Q1MTW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIV7", "url": "https://www.orthodb.org/?gene=E1BIV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21563", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21563", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21563:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21563:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9930044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003586079", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586079", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTW3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVP4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVP4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIV7", "url": "https://www.uniprot.org/uniprotkb/E1BIV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATADTPALASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPLHPARGGGSGGGGGSSSSSSSSQLQLRNFSRSRHASERGHLRGHSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHIALDRFRFRGRPYRGGSRWSRGRGGGDRGGKPGGRPLGGGAGSGFGSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKSENCGEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSIIKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGTKQLSLKSDATESSPGLEDKEQNLTRRISASDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQATDSGGGIYQYDNYEEVAMDTDSETNSPAPSPVQPPFFSECSLGYFSPAPSISLPPPPQVSSVPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSQPMPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPMRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIALVTKQVTDAEAKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAETKITKLTEQLQATEKILSVNRMFLKKLQEQIHRVQQRITIKKALTLKYGEELARAKAVASKEIGKRKLEQDRLGPNKMMRLDNSPISSPRRHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNIAPLVEEEPEFSLPQPSLHDLTQDKLSLDTEENDVDDEILSGSNRERRRSFLESNSFTKPNLKHTDTPNKECINKPTKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGISDKVLHGQEISVDVDFVTAQSKTTEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHTQDYTLSRKQLFQDVLSYNLSLIGCSEGSTDEEIAAAAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISENNFSSDEEQSTGPIKYAFQPENRINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGLCSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKEEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMVEFLMGAAKREASDTLSFQLLEALLFRVQLHIFTGRCQSALAILQNALKLATDGRVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNANPSRIVNIEPFVMPWQAVQDVKTNPDMLFAVFEDAVKACTDESLTVEERVETCVPLYTNMIVLHQLLERYEAAVELCKCLLESCPMNCQLLESLAALYLKMNQQDKARAVWVTAFEKSPQNAEVFYHTCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYSNLDLFRYLLNIPGPLDIPACLCKGNFDDEMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRSDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSIMPTNSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSYKTESKNH", "length": 1988, "header": "tr|E1BIV7-1|E1BIV7_BOVIN Isoform 1 of Zinc finger C3H1-type containing OS=Bos taurus OX=9913 GN=ZFC3H1 PE=4 SV=2 CANONICAL=E1BIV7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTW3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV7/entry#A0A3Q1MTW3-1", "sequence": { "sequence": "MATADTPALASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPLHPARGGGSGGGGGSSSSSSSSQLQLRNFSRSRHASERGHLRGHSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHIALDRFRFRGRPYRGGSRWSRGRGGGDRGGKPGGRPLGGGAGSGFGSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKSENCGEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSIIKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGTKQLSLKSDATESSPGLEDKEQNLTRRISASDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQATDSGGGIYQYDNYEEVAMDTDSETNSPAPSPVQPPFFSECSLGYFSPAPSISLPPPPQVSSVPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSQPMPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPMRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIALVTKQVTDAEAKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAETKITKLTEQLQATEKILSVNRMFLKKLQEQIHRVQQRITIKKALTLKYGEELARAKAVASKEIGKRKLEQDRLGPNKMMRLDNSPISSPRRHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNIAPLVEEEPEFSLPQPSLHDLTQDKLSLDTEENDVDDEILSGSNRERRRSFLESNSFTKPNLKHTDTPNKECINKPTKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGISDKVLHGQEISVDVDFVTAQSKTTEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHTQDYTLSRKQLFQDVLSYNLSLIGCSEGSTDEEIAAAAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISENNFSSDEEQSTGPIKYAFQPENRINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGLCSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKEEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMVEFLMGAAKREASDTLSFQLLEALLFRVQLHIFTGRCQSALAILQNALKLATDGRVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNANPSRIVNIEPFVMPWQAVQDVKTNPDMLFAVFEDAVKACTDESLTVEERVETCVPLYTNMIVLHQLLERYEAAVELCKCLLESCPMNCQLLESLAALYLKMNQQDKARAVWVTAFEKSPQNAEVFYHTCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYSNLDLFRYLLNIPGPLDIPACLCKGNFDDEMFNHQVPYLWLIYCYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSIMPTNSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSYKTESKNH", "length": 1953, "header": "tr|A0A3Q1MTW3-1|A0A3Q1MTW3_BOVIN Computationally mapped isoform of Zinc finger C3H1-type containing OS=Bos taurus OX=9913 GN=ZFC3H1 PE=4 SV=1 CANONICAL=E1BIV7-1" }, "locus": { "chromosome": "5", "start_pos": 1293905, "end_pos": 1244420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084505.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084505.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058199.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058199.1" } ] } }, { "isoform_ac": "A0A3Q1MVP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV7/entry#A0A3Q1MVP4-1", "sequence": { "sequence": "MAGKKGNKSLTTSLWAFLIPAETCCKLTRCSKSFGRSPSRKQNYSSKSENCGEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSIIKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGTKQLSLKSDATESSPGLEDKEQNLTRRISASDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQATDSGGGIYQYDNYEEVAMDTDSETNSPAPSPVQPPFFSECSLGYFSPAPSISLPPPPQVSSVPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSQPMPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPMRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIALVTKQVTDAEAKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAETKITKLTEQLQATEKILSVNRMFLKKLQEQIHRVQQRITIKKALTLKYGEELARAKAVASKEIGKRKLEQDRLGPNKMMRLDNSPISSPRRHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNIAPLVEEEPEFSLPQPSLHDLTQDKLSLDTEENDVDDEILSGSNRERRRSFLESNSFTKPNLKHTDTPNKECINKPTKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGISDKVLHGQEISVDVDFVTAQSKTTEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHTQDYTLSRKQLFQDVLSYNLSLIGCSEGSTDEEIAAAAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISENNFSSDEEQSTGPIKYAFQPENRINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGLCSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKEEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMVEFLMGAAKREASDTLSFQLLEALLFRVQLHIFTGRCQSALAILQNALKLATDGRVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNANPSRIVNIEPFVMPWQAVQDVKTNPDMLFAVFEDAVKACTDESLTVEERVETCVPLYTNMIVLHQLLERYEAAVELCKCLLESCPMNCQLLESLAALYLKMNQQDKARAVWVTAFEKSPQNAEVFYHTCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYSNLDLFRYLLNIPGPLDIPACLCKGNFDDEMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRSDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSIMPTNSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSYKTESKNH", "length": 1820, "header": "tr|A0A3Q1MVP4-1|A0A3Q1MVP4_BOVIN Computationally mapped isoform of Zinc finger C3H1-type containing OS=Bos taurus OX=9913 GN=ZFC3H1 PE=4 SV=2 CANONICAL=E1BIV7-1" }, "locus": { "chromosome": "5", "start_pos": 1294684, "end_pos": 1244420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086111.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086111.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059179.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059179.2" } ] } }, { "isoform_ac": "E1BIV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV7/entry#E1BIV7-1", "sequence": { "sequence": "MATADTPALASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPLHPARGGGSGGGGGSSSSSSSSQLQLRNFSRSRHASERGHLRGHSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHIALDRFRFRGRPYRGGSRWSRGRGGGDRGGKPGGRPLGGGAGSGFGSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKSENCGEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSIIKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGTKQLSLKSDATESSPGLEDKEQNLTRRISASDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQATDSGGGIYQYDNYEEVAMDTDSETNSPAPSPVQPPFFSECSLGYFSPAPSISLPPPPQVSSVPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSQPMPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPMRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIALVTKQVTDAEAKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAETKITKLTEQLQATEKILSVNRMFLKKLQEQIHRVQQRITIKKALTLKYGEELARAKAVASKEIGKRKLEQDRLGPNKMMRLDNSPISSPRRHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNIAPLVEEEPEFSLPQPSLHDLTQDKLSLDTEENDVDDEILSGSNRERRRSFLESNSFTKPNLKHTDTPNKECINKPTKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGISDKVLHGQEISVDVDFVTAQSKTTEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHTQDYTLSRKQLFQDVLSYNLSLIGCSEGSTDEEIAAAAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISENNFSSDEEQSTGPIKYAFQPENRINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGLCSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKEEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMVEFLMGAAKREASDTLSFQLLEALLFRVQLHIFTGRCQSALAILQNALKLATDGRVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNANPSRIVNIEPFVMPWQAVQDVKTNPDMLFAVFEDAVKACTDESLTVEERVETCVPLYTNMIVLHQLLERYEAAVELCKCLLESCPMNCQLLESLAALYLKMNQQDKARAVWVTAFEKSPQNAEVFYHTCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYSNLDLFRYLLNIPGPLDIPACLCKGNFDDEMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRSDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSIMPTNSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSYKTESKNH", "length": 1988, "header": "tr|E1BIV7-1|E1BIV7_BOVIN Isoform 1 of Zinc finger C3H1-type containing OS=Bos taurus OX=9913 GN=ZFC3H1 PE=4 SV=2 CANONICAL=E1BIV7-1" }, "locus": { "chromosome": "5", "start_pos": 1293905, "end_pos": 1244420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030417.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030417.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030399.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030399.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781886", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781886", "resource": "KEGG Pathway" }, { "id": "R-BTA-9930044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "resource": "Reactome", "description": "Nuclear RNA decay" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A504-1", "protein_name": "Zinc finger, C3H1-type containing", "gene_name": "Zfc3h1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATADTSTPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSTSSSGGGLLPYPRRRPPHPTRGGGSGGGGGSSSSSSSSQQQLRNFSRSRHPSERGHLRGHSSYRPKEPFRTHPPPVRMSSGSLSESSPRPSFWERSHIALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGGGGGGAGSGFGSSQSWREPSPPRKSSKSFGRSPSRKQNHSSKSENCGEETFEDLLLKYKQIQLELECINKDEKLALSSKEETVQEDPKTLHLEDQAGTNNANVTKDPSKEGAPEEKTQLKTFQAFELKPLRQKLTLPGDKNRVKRGKDGAKQLPLKSSTTDASQGLEDKEQNITRRISASDILSEKKLGEEEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTTQQKAKASTKAHSTKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKHAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLEKQPESGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFPECSLGYFSSAPSVSLPPPAQVSSVPSLSQPFGEGLCASLDPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEEASSNSDPPSPPVLNNSQPLSRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTSSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEMDGIGRIAMVTKQVADAEAKLKKHKILLIKDESVLKNLVLQEAKKKESVRNAEAKITKLTEQLQAAEKILSVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKELGKRKLEQDRLGPNKMMRLDNSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNLVPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDADDEVLSGSNRERRRSFLESNSFTKPNLKHTDTPNKECVNKLSKSTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITENILHGQEISVDVDFVTAQSKTTEVKPCPFRPYQSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLAGTCNDDDCQWQHVQDYTLSRKQLFQDILSYNLSLIGCSETSTDEEIASATEKYVEKLFGVNKDRMSMDQMAVLLVSNVNESKGHTPPFTTYKDKRKWKPKFCRKPASENSCSSDDEQSTGPIKYAFRPENQINVPALDTVVTPDDVRYFTSETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGLCSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKEEVQEMCETAVEYAPDYQSFCTFLHLESTFEEKDYVCERMVEFLMGAAKRETSDILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKLANDAIVAEYLRTEDRCLAWLAYIHLIEFNSLPSKLYDPSNANPSRIVNTEPFVMPWQAAQDVKTNPDLLLAVFEDAVKACTDEALTSGERTEVCLPLYTNMMALHQLLERDEEAVELCKSLLESCPTNCQLLETLAALYLKTDCYDKARWVWLTAFENNPQNAEIFYHLCKFFILQNGGDKLLPLLRQFIGSFFKPGFEKYSNVDLFRYLLNIPGPLDIPACLCKGNFDDDVFNNQVPYLWLIYCLCHPLQSSIKETIEAYEAALGVAMRSDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSRLALRLLQHEWEESNVQILKLQAKMFTYNLPTCLATWKIAIAAEIALKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNL", "length": 1994 }, "evidence": [ { "id": "E1BIV7", "url": "https://omabrowser.org/oma/group/E1BIV7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YAQ2-1", "protein_name": "Zinc finger C3H1-type containing", "gene_name": "ZFC3H1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAEAAPAEAALDSSGLSPKEEGELEDGEISDDDNNGSGPCGGGSEPGGGLAGNRPYSRRRPPPGLRGGISLSSSRRFPRSRHQPPPEMGHLHGHGGYRPKDSFRSHPPPLPAPRMPSGPHSETGPRLSFWERSHNALDRFRFRGRPYRGGWRWGRSRGGGERGGNPPGRPPGGGSCAGFSGNQGWREPSPRKSKTFGRSPSRKQNYSSKSENSVEESFEDLLLKYKQIQLELEYINKDERLALSNREENKQQDDSKTADTEDQITVENDSIKTDAIKEVSPEEKNPVMAFQAFELKPLRQKLPTPAERSRLKKVKEGTKQSSQKSEATESTQGAEDKEQTSTRKPSSSDVTSEKKLLEEEEEMSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVTQKVKASAKAHSTKKTSSTGKQTLRKQQTKTSKKIQQQKEQDRRQKEEDQRKQEEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSRSSDTDLRWSLDKPSTDSAGGIYQYDNYDEVAMDTDSETNSPASSPAQPPYFECPVGYYPPPTIPPISLPLPPPIPPLPSLSQLYMEGISCVSLEPPPPLPPLPPEEPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFRSEETSSNSGPPSPPVPDNLQSVPRSNLSAVSINTVSQPRVQNTKFVRVPRPPRAVITLPKHKSVVVTLNDSDDSESDGEPSNSTNSVFGGLESMIKEARRNVEASRIKAPPKSEKENDPMRTPEALPEDKKIEYRLLKEEIASREKQRLVKSDPLKNSSSPANSDGEVDGIGRIAVATKQVTEAEAKLKRNKLLLMKDESVLKHLLQQEAKKRENVRIAENKINKLAEQLQATEKILNANKMFLKKLQEQIHKVQQRVTVKKALALKYGEELARAKAVASKEIGKRKLEQEHLGPSKMLKLENSPASSPKKHSAELIALEKKRLQQLEYEYALKIQKLKEARALQTKEQSDIAPQAEEEAEFALPQPSLHDLTQDKLSLDSEENYFDDEVLSNSNRERRRSFRESSSYTKPNLKHMDTPKQEPINKLSKKAAEEPELFLGLNIDELKKLYAKADSLKELLVKSTAFVAPKEDLLCGQEISVDMDFVTSQNKQTEAKPFPFGPYRSPLLVFKSYRFSPYFRTKEKLYLSSVTYSNMIEPKQCFCRFDLTGTCNDDDCQWQHMKDCTLSRKQLFQDILSYNLELIGCSEKSTDEEISTATEKYVEKLFGINRDRMSVDQMAVLLASNVNESKGHTPPFTTWKDKRKWRPKYWRKPLLDSSSSEEEQSGPIKYAHPTEHKKRIPALDTVVTPDDIRYFTSETDDISNLEASVQENPCNVQLWIKLAYKYLNQNEGSSSECLDSTLNVLARALENNKENPEIWCHYLRLFSKRGTKEEIQEMCETAVEYAASYQIWWTFLNLESSFDGKDYVCGRILQFLMEVTEGEENPNLLSFQLLETLLYRVHLSLFTGRYQNALLLLQNALKSANEKIISERLTLSDRCLAWLSYIHLIEFNILPVKFYDPANVGPSRIMNKEPFLIPWQTVQDVKTDPDTLLAMFEDAVKTCTDENLEADKRIAVCFPLYRNMIALLKLLERWESAVELCRSLLELCPNNCLLLESLATLYLQMEQSESAYGVWIGAFEKNTQNAEIFYQLCKFLTSQERSDSVLPLLQDFVAAFFENTYQQHDSMDLLRYLLNFPMPIEFTAPLYKEHLTDDIVNQQIPYLWQIYCLCQSLHASVGEALDAYEAALGAVMQQEIVQNIWMDYLVFMNNKVVGSSNKVQEFKVFTDLVNRCLVTVPTRYPIPFSAADYWTNYEFHNKVVFFYLSCIPKSQHSKTLERFCSTMPANPGLALRLLLRYWEESNVQILKLQAKMFTYNIPTCLAIWKIAIAAECFLMGQREVHHLYQRALHKLPLCATLWKDQLLFEASGGGKTDNLRKLVSKCQEVGVSLDELLSLNTCRTECKNL", "length": 1984 }, "evidence": [ { "id": "E1BIV7", "url": "https://omabrowser.org/oma/group/E1BIV7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O60293-1", "protein_name": "Zinc finger C3H1 domain-containing protein", "gene_name": "ZFC3H1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNH", "length": 1989 }, "evidence": [ { "id": "E1BIV7", "url": "https://omabrowser.org/oma/group/E1BIV7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BIV7", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" } ], "pmid": "" }, { "name": "MTREC complex", "id": "GO:1990477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990477", "evidence": [ { "database": "UniProtKB", "id": "E1BIV7", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "E1BIV7", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1221, "end_pos": 1223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1269, "end_pos": 1271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1300, "end_pos": 1302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1341, "end_pos": 1343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" }, { "start_pos": 668, "end_pos": 670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV7" }, { "id": "PF10650", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10650" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Putative zinc-finger", "eco_id": "ECO_0000259", "start_pos": 1184, "end_pos": 1202, "start_aa": "Phe", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1221, "end_pos": 1223 }, { "start_pos": 1269, "end_pos": 1271 }, { "start_pos": 1300, "end_pos": 1302 }, { "start_pos": 1341, "end_pos": 1343 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 32, "end_pos": 34 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 659, "end_pos": 661 }, { "start_pos": 668, "end_pos": 670 }, { "start_pos": 711, "end_pos": 713 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIV8-1", "uniprot_ac": "E1BIV8", "uniprot_id": "E1BIV8_BOVIN", "mass": { "chemical_mass": 75632.0, "monoisotopic_mass": 75632.0 }, "refseq": { "ac": "XP_059736993", "name": "uncharacterized protein C18orf63 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736993" }, "gene_names": [ { "name": "C24H18orf63", "type": "recommended", "evidence": [ { "id": "E1BIV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV8" } ] }, { "name": "C24H18orf63", "type": "synonym", "evidence": [ { "id": "XP_059736993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736993" } ] } ], "protein_names": [ { "name": "Chromosome 24 C18orf63 homolog", "type": "synonym", "evidence": [ { "id": "E1BIV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV8/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C18orf63 homolog", "type": "synonym", "evidence": [ { "id": "XP_059736993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736993" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIV8", "url": "https://www.uniprot.org/uniprotkb/E1BIV8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C24H18orf63", "url": "https://www.uniprot.org/uniprotkb/E1BIV8", "locus": { "chromosome": "24", "start_pos": 4103750, "end_pos": 4130787, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022466", "url": "https://www.ensembl.org/id/ENSBTAG00000022466" } ] } } ], "crossref": [ { "id": "E1BIV8", "url": "https://alphafold.ebi.ac.uk/entry/E1BIV8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022466", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022466", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100848078", "url": "https://www.ncbi.nlm.nih.gov/gene/100848078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR28495", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28495", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28495:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28495:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15813", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15813", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059736993", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIV8", "url": "https://www.uniprot.org/uniprotkb/E1BIV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIV8-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDSKQQSLFFITLPDLHKLCAVKIILSNGVAGTEIRSRQMKICRQLLFLHQDILTSPVPGIFTQIWAVMAITFYKAGKLNAYMEKYGAKVEAPQQVIPIILQNCLSYSLTARLAPAWNKAGHLLIQGREFLSQMGKQSAVVLDINVTSTQVCLSIEVHTVRLPPPQLREFDISQSIIKSFETNQNAVIEEQSILSNWCYVLPSMKMGRLISILHTIPPDCPFHSYEDFQMHWDGLYGYKLPEDLGTIKIYCCIYFKMIGERLFTYPLSCVRSQPIQFFPRVDMEGVLRSFLSDLKSKLPHICGFPIKMTTKPCYYTQELTTLHLQGNKVKPPNLTAQAKSSPAHTPSTRAARAPSFPPCSAAAGHKGARSVSPPKPSGSSALRLQPESVLSSKKAPSDQAAQVLEVPKPTRGNAQVQDTNFSSQHNIAPRFIPVFKSRPLQMTKSILAPENLRRKRVDTESKLFSLKSSEIQDDKPNVDPTTKKRPSHSIQMKAKNLNLKTCRSLQEKNTESYGNMTKSPLSSGKSLITSLSESKQLSNSSVFQMPTSNLDVLKSAVGSQVNGKENLTSKYITQVLGKSHESLKVKRQPHIFESDTDPEDSQPLQPQSVDQTKEADVTDRQLTVSRTAPKSKKLCQDSLKTSKKPHSNTVLCGQSRARKQIHHLDKSKPKKSLIPKA", "length": 678, "header": "tr|E1BIV8-1|E1BIV8_BOVIN Isoform 1 of Chromosome 24 C18orf63 homolog OS=Bos taurus OX=9913 GN=C24H18orf63 PE=4 SV=4 CANONICAL=E1BIV8-1" }, "isoforms": [ { "isoform_ac": "E1BIV8-1", "url": "https://www.uniprot.org/uniprotkb/E1BIV8/entry#E1BIV8-1", "sequence": { "sequence": "MNDSKQQSLFFITLPDLHKLCAVKIILSNGVAGTEIRSRQMKICRQLLFLHQDILTSPVPGIFTQIWAVMAITFYKAGKLNAYMEKYGAKVEAPQQVIPIILQNCLSYSLTARLAPAWNKAGHLLIQGREFLSQMGKQSAVVLDINVTSTQVCLSIEVHTVRLPPPQLREFDISQSIIKSFETNQNAVIEEQSILSNWCYVLPSMKMGRLISILHTIPPDCPFHSYEDFQMHWDGLYGYKLPEDLGTIKIYCCIYFKMIGERLFTYPLSCVRSQPIQFFPRVDMEGVLRSFLSDLKSKLPHICGFPIKMTTKPCYYTQELTTLHLQGNKVKPPNLTAQAKSSPAHTPSTRAARAPSFPPCSAAAGHKGARSVSPPKPSGSSALRLQPESVLSSKKAPSDQAAQVLEVPKPTRGNAQVQDTNFSSQHNIAPRFIPVFKSRPLQMTKSILAPENLRRKRVDTESKLFSLKSSEIQDDKPNVDPTTKKRPSHSIQMKAKNLNLKTCRSLQEKNTESYGNMTKSPLSSGKSLITSLSESKQLSNSSVFQMPTSNLDVLKSAVGSQVNGKENLTSKYITQVLGKSHESLKVKRQPHIFESDTDPEDSQPLQPQSVDQTKEADVTDRQLTVSRTAPKSKKLCQDSLKTSKKPHSNTVLCGQSRARKQIHHLDKSKPKKSLIPKA", "length": 678, "header": "tr|E1BIV8-1|E1BIV8_BOVIN Isoform 1 of Chromosome 24 C18orf63 homolog OS=Bos taurus OX=9913 GN=C24H18orf63 PE=4 SV=4 CANONICAL=E1BIV8-1" }, "locus": { "chromosome": "24", "start_pos": 4127824, "end_pos": 4103786, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030415.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030415.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030397.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030397.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848078", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 540, "end_pos": 542, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIV8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 678, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIV8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIV8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIV8" }, { "id": "PF15813", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15813" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4708", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 280, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 540, "end_pos": 542 }, { "start_pos": 567, "end_pos": 569 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIW2-1", "uniprot_ac": "E1BIW2", "uniprot_id": "E1BIW2_BOVIN", "mass": { "chemical_mass": 58567.0, "monoisotopic_mass": 58567.0 }, "refseq": { "ac": "NP_001179964", "name": "BEN domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964" }, "gene_names": [ { "name": "BEND4", "type": "recommended", "evidence": [ { "id": "E1BIW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW2" } ] }, { "name": "BEND4", "type": "synonym", "evidence": [ { "id": "NP_001179964", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964" } ] }, { "name": "CCDC4", "type": "synonym", "evidence": [ { "id": "NP_001179964", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964" } ] } ], "protein_names": [ { "name": "BEN domain containing 4", "type": "synonym", "evidence": [ { "id": "E1BIW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW2/entry#names_and_taxonomy" } ] }, { "name": "BEN domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001179964", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964" } ] }, { "name": "coiled-coil domain containing 4", "type": "synonym", "evidence": [ { "id": "NP_001179964", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIW2", "url": "https://www.uniprot.org/uniprotkb/E1BIW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BEND4", "url": "https://www.uniprot.org/uniprotkb/E1BIW2", "locus": { "chromosome": "6", "start_pos": 60981592, "end_pos": 61011643, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005567", "url": "https://www.ensembl.org/id/ENSBTAG00000005567" } ] } } ], "crossref": [ { "id": "E1BIW2", "url": "https://alphafold.ebi.ac.uk/entry/E1BIW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005567", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005567", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614525", "url": "https://www.ncbi.nlm.nih.gov/gene/614525", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614525", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614525", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLRFIRM", "url": "https://omabrowser.org/oma/group/CLRFIRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIW2", "url": "https://www.orthodb.org/?gene=E1BIW2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35082:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35082:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10523", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10523", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179964", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIW2", "url": "https://www.uniprot.org/uniprotkb/E1BIW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIW2-1", "url": "https://www.uniprot.org/uniprotkb/E1BIW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEEMQPAEEGPSVPKIYKQRGPYSVLKTFPGKRPALAKRYERPTLVELPHVRPPPPPFAPHAVVSISSSEPPPPPPPQQQQFQAQGSFPPGPGRANAAASSSSPSGTPAASQGHLRTTAAPPAAAAAASSSSSFAAVVRYGSSPAASAGSSSTGGDGASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYTERQEPCPVGKGVHSQTSDSLDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNTSSVSEYGHLADVDPLSTSPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEEEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKMVLQHHNQLMIPQPADQPTEGSKQLLNNYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGIDHQPSQDEVFNKNSQDGSGD", "length": 537, "header": "tr|E1BIW2-1|E1BIW2_BOVIN Isoform 1 of BEN domain containing 4 OS=Bos taurus OX=9913 GN=BEND4 PE=4 SV=3 CANONICAL=E1BIW2-1" }, "isoforms": [ { "isoform_ac": "E1BIW2-1", "url": "https://www.uniprot.org/uniprotkb/E1BIW2/entry#E1BIW2-1", "sequence": { "sequence": "MEEEMQPAEEGPSVPKIYKQRGPYSVLKTFPGKRPALAKRYERPTLVELPHVRPPPPPFAPHAVVSISSSEPPPPPPPQQQQFQAQGSFPPGPGRANAAASSSSPSGTPAASQGHLRTTAAPPAAAAAASSSSSFAAVVRYGSSPAASAGSSSTGGDGASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYTERQEPCPVGKGVHSQTSDSLDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNTSSVSEYGHLADVDPLSTSPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEEEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKMVLQHHNQLMIPQPADQPTEGSKQLLNNYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGIDHQPSQDEVFNKNSQDGSGD", "length": 537, "header": "tr|E1BIW2-1|E1BIW2_BOVIN Isoform 1 of BEN domain containing 4 OS=Bos taurus OX=9913 GN=BEND4 PE=4 SV=3 CANONICAL=E1BIW2-1" }, "locus": { "chromosome": "6", "start_pos": 61011444, "end_pos": 60982596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049892.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049892.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046715.3", "url": "https://www.ensembl.org/id/ENSBTAP00000046715.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 108, "start_aa": "Thr", "end_pos": 108, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614525", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614525", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K5Z6-1", "protein_name": "BEN domain containing 4", "gene_name": "Bend4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPEMQAAEEGPSAPRIYKQRGPYSVLKTFPSRRPALAKRYDRPSLLELSPARPSPLPPPPPPPPFASLAAVPISSSEPPPFPTQPSYPAGSGRAPAAAAASSSSPSCTPAAPPGHPRTPAPPPPPPPPPPLAAPAASSSSSFAAVVRYGPGPASGAGSSGAGSDGASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSSHSQSMISCVKQEGSSYNERQDQCHIVKGVQSQTSDNIDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGNFPTPNTSSVSEYGHLADVDPLSASPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKTVLLHHNQLLPQPAEQPTEGSKQLLNSYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGMDHQASQDEVFNKSSQDGSGD", "length": 543 }, "evidence": [ { "id": "E1BIW2", "url": "https://omabrowser.org/oma/group/E1BIW2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A2R8QJE3-1", "protein_name": "BEN domain-containing protein 4", "gene_name": "bend4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEEMLPADEGLSAAKISRQQRSPYSSLKTFPSKRTVGKARYDDRPTMVDIPQLGDHHHHLSHQHQQQFSQRVPLPQSPLPISSSTHQHRLPCEIRPSSRASSAGSGAAASASFGSPRRVAVAGQESGRLRAEISHQTPDCTYGISSENRLILDAFAQQCSRVLSLLNSNGRLLEPQPSLIPPSSSMSTALIKQEESCLSPEERLSSKPRSPSVENAGEETQRGNQWNQQQTSTFLRIFTESLQNYLLSGPQPSDGERCRQVDAEPVASGSPRQNLSGWASPAPSESYGHPSSTLPEEDEEEEGCCPRCVELEQEVLSLQQENEELRHKLDSIPAPCQNVLDFFKTVLQHYNQFVQPQPEEQLTEGSKQLLGNYPLFITNKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVHTGDTGPERRPLNPVKVTCLREFIRMHCASNPDWWMPSEEQINKVFSDAVGHARQGRAVGSFLGGSGSSSSGSLYMESYDGQLSQDELYLKGSQNGLVD", "length": 523 }, "evidence": [ { "id": "E1BIW2", "url": "https://omabrowser.org/oma/group/E1BIW2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P86174-1", "protein_name": "BEN domain-containing protein 4", "gene_name": "Bend4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPEMQAAEEGPSAPRIYKQRGPYSVLKTFPSRRPALAKRYDRPSLLELSPARPSPLPPPPPPPPFASLAAVPISSSEPPPFPTQPSYPAGSGRAPAAAAASSSSPSCTPAAPPGHPRTPAPPPPPPPPLAAPAASSSSSFAAVVRYGPGPATGACSSGAGSDGASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYNERQDQCHIVKGVQSQTSDNIDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNTSSASEYGHLADVDPLSASPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEEEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKTVLLHHNQLLPQPAEQPTEGSKQLLNNYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGMDHQASQDEVFSKTQDGSGD", "length": 541 }, "evidence": [ { "id": "E1BIW2", "url": "https://omabrowser.org/oma/group/E1BIW2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZU67-1", "protein_name": "BEN domain-containing protein 4", "gene_name": "BEND4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEEMQPAEEGPSVPKIYKQRSPYSVLKTFPSKRPALAKRYERPTLVELPHVRAPPPPPPPFAPHAAVSISSSEPPPQQFQAQSSYPPGPGRAAAAASSSSPSCTPATSQGHLRTPAQPPPASPAASSSSSFAAVVRYGPGAAAAAGTGGTGSDSASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYNERQEHCHIGKGVHSQTSDNVDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNPSSASEYGHLADVDPLSTSPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEDEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKMVLQHHNQLLIPQPADQPTEGSKQLLNNYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGIDHQASQDEVFNKSSQDGSGD", "length": 534 }, "evidence": [ { "id": "E1BIW2", "url": "https://omabrowser.org/oma/group/E1BIW2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BIW2", "url": "https://www.uniprot.org/uniprotkb/E1BIW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIW2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 537, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIW2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIW2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW2" }, { "id": "PS51457", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51457" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEN", "eco_id": "ECO_0000259", "start_pos": 393, "end_pos": 501, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 108 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 408, "end_pos": 410 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIW6-1", "uniprot_ac": "E1BIW6", "uniprot_id": "E1BIW6_BOVIN", "mass": { "chemical_mass": 26351.0, "monoisotopic_mass": 26351.0 }, "refseq": { "ac": "XP_002697178", "name": "MKRN2 opposite strand protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697178" }, "gene_names": [ { "name": "MKRN2OS", "type": "recommended", "evidence": [ { "id": "E1BIW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW6" } ] }, { "name": "MKRN2OS", "type": "synonym", "evidence": [ { "id": "XP_002697178", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697178" } ] } ], "protein_names": [ { "name": "MKRN2 opposite strand protein", "type": "synonym", "evidence": [ { "id": "XP_002697178", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697178" } ] }, { "name": "MKRN2 opposite strand", "type": "synonym", "evidence": [ { "id": "E1BIW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIW6", "url": "https://www.uniprot.org/uniprotkb/E1BIW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MKRN2OS", "url": "https://www.uniprot.org/uniprotkb/E1BIW6", "locus": { "chromosome": "22", "start_pos": 56600917, "end_pos": 56594310, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024991", "url": "https://www.ensembl.org/id/ENSBTAG00000024991" } ] } } ], "crossref": [ { "id": "E1BIW6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024991", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024991", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782327", "url": "https://www.ncbi.nlm.nih.gov/gene/782327", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782327", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782327", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BIW6", "url": "https://www.orthodb.org/?gene=E1BIW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33963", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33963", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33963:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33963:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16044", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16044", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22795", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22795", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697178", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697178", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BIW6", "url": "https://www.uniprot.org/uniprotkb/E1BIW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIW6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRRKSGELAPLARDREAMQCPEAGKPIVKVNHCQKYVYSFGVPRRCPLCGQDVGSRRLEEAPVSISEPFTNGHREKCSFLLRPTRGTFLREYDGRSDLHVGITNTGGVVYNYTVHGVQRDEVGWEQSVSVPLLRPGLFGLLDQWDKYLEDFSATGAWLPHRYEEDHHNCYSYALAFINCVLATEGEEQLDRDEFTEKFVVPRTRKASKYITLYRAIEERGFYVTDPPGP", "length": 230, "header": "tr|E1BIW6-1|E1BIW6_BOVIN Isoform 1 of MKRN2 opposite strand OS=Bos taurus OX=9913 GN=MKRN2OS PE=4 SV=5 CANONICAL=E1BIW6-1" }, "isoforms": [ { "isoform_ac": "E1BIW6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIW6/entry#E1BIW6-1", "sequence": { "sequence": "MRRRKSGELAPLARDREAMQCPEAGKPIVKVNHCQKYVYSFGVPRRCPLCGQDVGSRRLEEAPVSISEPFTNGHREKCSFLLRPTRGTFLREYDGRSDLHVGITNTGGVVYNYTVHGVQRDEVGWEQSVSVPLLRPGLFGLLDQWDKYLEDFSATGAWLPHRYEEDHHNCYSYALAFINCVLATEGEEQLDRDEFTEKFVVPRTRKASKYITLYRAIEERGFYVTDPPGP", "length": 230, "header": "tr|E1BIW6-1|E1BIW6_BOVIN Isoform 1 of MKRN2 opposite strand OS=Bos taurus OX=9913 GN=MKRN2OS PE=4 SV=5 CANONICAL=E1BIW6-1" }, "locus": { "chromosome": "22", "start_pos": 56600644, "end_pos": 56594356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034856.7", "url": "https://www.ensembl.org/id/ENSBTAT00000034856.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034740.7", "url": "https://www.ensembl.org/id/ENSBTAP00000034740.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782327", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782327", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIW6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIW6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIW6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BIW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW6" }, { "id": "PF16044", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MKRN2 opposite strand protein-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 63, "end_pos": 217, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BIW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW6" }, { "id": "PF22795", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22795" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MKRN2 opposite strand protein-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 53, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BIX6-1", "uniprot_ac": "E1BIX6", "uniprot_id": "E1BIX6_BOVIN", "mass": { "chemical_mass": 36614.0, "monoisotopic_mass": 36614.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD33", "type": "recommended", "evidence": [ { "id": "E1BIX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIX6" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 33", "type": "synonym", "evidence": [ { "id": "E1BIX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIX6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BIX6", "url": "https://www.uniprot.org/uniprotkb/E1BIX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD33", "url": "https://www.uniprot.org/uniprotkb/E1BIX6", "locus": { "chromosome": "5", "start_pos": 27974153, "end_pos": 27977581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017113", "url": "https://www.ensembl.org/id/ENSBTAG00000017113" } ] } } ], "crossref": [ { "id": "E1BIX6", "url": "https://alphafold.ebi.ac.uk/entry/E1BIX6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BIX6", "url": "https://www.uniprot.org/uniprotkb/E1BIX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIX6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIX6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDQEPTWQKGGLDASEAPSCLDSEASTPSCTLGALYWACVRNDPAQLQAMLDDGVSPEEATQVDGNGRTGLMVACYHGFQSVVALLSRCPFLDVNQQDKEGDTALMLAAQAGHVSLVSHLINYYAGLDLERRDQRGLTALMKAAMRDRSECVAALLMAGADLTAVDPVRGKTALEWAFLTDSFDTVQRIRQLLRRPQVEQLSQHYQPEWPALPGLVAQAQAAPSLLERLQATLTLPFVQSPQEGGVLDQLVTITTSLASPFLTTACHTLCPDHPPALGTRRKSVPELLVEARAQVFREPKAVPSCLEIPGAQDGEEETGGGRIDTEPGEDRLGWAGSR", "length": 339, "header": "tr|E1BIX6-1|E1BIX6_BOVIN Isoform 1 of Ankyrin repeat domain 33 OS=Bos taurus OX=9913 GN=ANKRD33 PE=4 SV=4 CANONICAL=E1BIX6-1" }, "isoforms": [ { "isoform_ac": "E1BIX6-1", "url": "https://www.uniprot.org/uniprotkb/E1BIX6/entry#E1BIX6-1", "sequence": { "sequence": "MEDQEPTWQKGGLDASEAPSCLDSEASTPSCTLGALYWACVRNDPAQLQAMLDDGVSPEEATQVDGNGRTGLMVACYHGFQSVVALLSRCPFLDVNQQDKEGDTALMLAAQAGHVSLVSHLINYYAGLDLERRDQRGLTALMKAAMRDRSECVAALLMAGADLTAVDPVRGKTALEWAFLTDSFDTVQRIRQLLRRPQVEQLSQHYQPEWPALPGLVAQAQAAPSLLERLQATLTLPFVQSPQEGGVLDQLVTITTSLASPFLTTACHTLCPDHPPALGTRRKSVPELLVEARAQVFREPKAVPSCLEIPGAQDGEEETGGGRIDTEPGEDRLGWAGSR", "length": 339, "header": "tr|E1BIX6-1|E1BIX6_BOVIN Isoform 1 of Ankyrin repeat domain 33 OS=Bos taurus OX=9913 GN=ANKRD33 PE=4 SV=4 CANONICAL=E1BIX6-1" }, "locus": { "chromosome": "5", "start_pos": 27976849, "end_pos": 27974156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022764.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022764.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022764.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022764.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 28, "start_aa": "Thr", "end_pos": 28, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BIX6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 339, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BIX6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BIX6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 28 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ10-1", "uniprot_ac": "E1BJ10", "uniprot_id": "E1BJ10_BOVIN", "mass": { "chemical_mass": 38683.0, "monoisotopic_mass": 38683.0 }, "refseq": { "ac": "NP_001179048", "name": "myosin-binding protein H-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179048" }, "gene_names": [ { "name": "MYBPHL", "type": "recommended", "evidence": [ { "id": "E1BJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" } ] }, { "name": "MYBPHL", "type": "synonym", "evidence": [ { "id": "NP_001179048", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179048" } ] } ], "protein_names": [ { "name": "Myosin-binding protein H-like", "type": "recommended", "evidence": [ { "id": "E1BJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ10/entry#names_and_taxonomy" } ] }, { "name": "myosin-binding protein H-like", "type": "synonym", "evidence": [ { "id": "NP_001179048", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179048" } ] } ], "function": [ { "annotation": "Myosin-binding protein which plays a role in cardiac function. Seems to regulate conduction in the atria and ventricular conduction systems.", "evidence": [ { "database": "UniProtKB", "id": "E1BJ10", "url": "https://www.uniprot.org/uniprotkb/E1BJ10#function" }, { "database": "UniProtKB", "id": "ARBA00059357", "url": "https://www.uniprot.org/uniprotkb/ARBA00059357#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ10", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYBPHL", "url": "https://www.uniprot.org/uniprotkb/E1BJ10", "locus": { "chromosome": "3", "start_pos": 34119705, "end_pos": 34107543, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018807", "url": "https://www.ensembl.org/id/ENSBTAG00000018807" } ] } } ], "crossref": [ { "id": "E1BJ10", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018807", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018807", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05748", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05748", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538875", "url": "https://www.ncbi.nlm.nih.gov/gene/538875", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538875", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538875", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NGCALDT", "url": "https://omabrowser.org/oma/group/NGCALDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ10", "url": "https://www.orthodb.org/?gene=E1BJ10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179048", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ10", "url": "https://www.uniprot.org/uniprotkb/E1BJ10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ10-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAATAPEAALRPTLKVKEASPADADGPQASPRRGTGSPLSQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTRDGCALDTSRVSVRNGERDSILFIREAQRADSGRYQLSVQLGGLEATATIDILVIERPGPPQSIKLVDVWGSSATLEWTPPQDTGNAALLGYTVQKADTKSGLWFTVLERCRRASCTVPNLIVGNSYTFRVFAENQCGLSENAPITADLAHIQKAATVYRTEGFAQRDFSEAPKFTQPLADCTTVIGYDTQLFCCVRASPKPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKAPN", "length": 354, "header": "tr|E1BJ10-1|E1BJ10_BOVIN Isoform 1 of Myosin-binding protein H-like OS=Bos taurus OX=9913 GN=MYBPHL PE=3 SV=1 CANONICAL=E1BJ10-1" }, "isoforms": [ { "isoform_ac": "E1BJ10-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ10/entry#E1BJ10-1", "sequence": { "sequence": "MEAATAPEAALRPTLKVKEASPADADGPQASPRRGTGSPLSQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTRDGCALDTSRVSVRNGERDSILFIREAQRADSGRYQLSVQLGGLEATATIDILVIERPGPPQSIKLVDVWGSSATLEWTPPQDTGNAALLGYTVQKADTKSGLWFTVLERCRRASCTVPNLIVGNSYTFRVFAENQCGLSENAPITADLAHIQKAATVYRTEGFAQRDFSEAPKFTQPLADCTTVIGYDTQLFCCVRASPKPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKAPN", "length": 354, "header": "tr|E1BJ10-1|E1BJ10_BOVIN Isoform 1 of Myosin-binding protein H-like OS=Bos taurus OX=9913 GN=MYBPHL PE=3 SV=1 CANONICAL=E1BJ10-1" }, "locus": { "chromosome": "3", "start_pos": 34119672, "end_pos": 34107569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025035.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025035.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025035.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025035.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538875", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538875", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MW21-1", "protein_name": "Myosin-binding protein H-like", "gene_name": "Mybphl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METAPTLEMALCSQQQVEAAADPADAEGPQEADSPSPQLLPSIEEHPKIWLPRTLRQTYIRKVGDTVNLLIPIQGKPKPQTTWTHNGSALDNSRVSVRNGEQDSILFIREAQRADSGCYQLCVQLGGLQATATINILVIEKPGPPQSIKLVDVWGSNATLEWTPPQDTGNTALLGYTVQKADKKSGLWFTVLEHYHRTSCIVSDLIVGNSYAFRVFAENQCGLSETAPVTADLAYIQKADTVYKTKGFAQRDLSEAPRFTQPLVDCTTITGYDTQLFCCVRASPRPKIIWLKNKMDLQGNPKYRALSHLGICSLEIRKPSPFDGGIYTCKAINALGEASVDCRVDVKAPH", "length": 350 }, "evidence": [ { "id": "E1BJ10", "url": "https://omabrowser.org/oma/group/E1BJ10/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2RUH7-1", "protein_name": "Myosin-binding protein H-like", "gene_name": "MYBPHL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAATAPEVAAGSKLKVKEASPADAEPPQASPGQGAGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALDTRRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLADCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVPN", "length": 354 }, "evidence": [ { "id": "E1BJ10", "url": "https://omabrowser.org/oma/group/E1BJ10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5FW53-1", "protein_name": "Myosin-binding protein H-like", "gene_name": "Mybphl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METATTLEIASCSQRQVEAAADPADAKGPRTSHQQEAGSPSLQLLPSIEEHPKIWLPRALKQTYIRKAGETVNLLIPIQGKPKPQTTWTHNGCALDSSRVSVRNGEHDSILFIREAQRTDSGCYQLCVQLGGLQATATINILVIEKPGPPQSIKLVDVWGANATLEWTPPQDTGNTALLGYTVQKADKKSGLWFTVLERYHRTSCVVSNLIVGNSYAFRVFAENQCGLSDTAPVTADLAHIQKAATVYKAKGFAQRDLSEAPKFTQPLADCTTVTGYDTQLFCCVRASPRPKIIWLKNKMDLQGNPKYRALSQLGICSLEIRKPSPFDGGIYTCKAINALGEASVDCRVDVKAPH", "length": 355 }, "evidence": [ { "id": "E1BJ10", "url": "https://omabrowser.org/oma/group/E1BJ10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5PQM4-1", "protein_name": "Myosin-binding protein H-like", "gene_name": "Mybphl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METATTLEIASCSQRQVEEAADPADAEGPQTTRQQEAGSPSLQLLPSIEEHPKIWLPRALRQTYIRKVGETVNLLIPFQGKPKPQTIWTHNGSALDNSRVSVRNGEHDSILFIREAQRTDSGCYQLCVQLGGLQATATINILVIEKPGPPQSIKLVDVWGANATLEWTPPQDTGNTALLGYTVQKADKKSGLWFTVLERYHRTSCIVSDLIVGNSYAFRVFAENQCGLSDTAPVTADLAHIQKAATVYKAKGFAQRDLSEAPKFTQPLADCTTVTGYDTQLFCCVRASPKPKIIWLKNKMDLQGNPKYRALSQLGICSLEIRKPSPFDGGIYTCKAINALGEASVDCRVDVKAPH", "length": 355 }, "evidence": [ { "id": "E1BJ10", "url": "https://omabrowser.org/oma/group/E1BJ10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sarcomere", "id": "GO:0030017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "evidence": [ { "database": "UniProtKB", "id": "E1BJ10", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" } ], "pmid": "" }, { "name": "myofilament", "id": "GO:0036379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036379", "evidence": [ { "database": "UniProtKB", "id": "E1BJ10", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ10-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ10-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ10" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 148, "end_pos": 243, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ10" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 139, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ12-1", "uniprot_ac": "E1BJ12", "uniprot_id": "E1BJ12_BOVIN", "mass": { "chemical_mass": 30029.0, "monoisotopic_mass": 30029.0 }, "refseq": { "ac": "NP_001179710", "name": "ankyrin repeat and SOCS box protein 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179710" }, "gene_names": [ { "name": "ASB13", "type": "recommended", "evidence": [ { "id": "E1BJ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ12" } ] }, { "name": "ASB13", "type": "synonym", "evidence": [ { "id": "NP_001179710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179710" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box containing 13", "type": "synonym", "evidence": [ { "id": "E1BJ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ12/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 13", "type": "synonym", "evidence": [ { "id": "NP_001179710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179710" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ12", "url": "https://www.uniprot.org/uniprotkb/E1BJ12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB13", "url": "https://www.uniprot.org/uniprotkb/E1BJ12", "locus": { "chromosome": "13", "start_pos": 43046767, "end_pos": 43031397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018805", "url": "https://www.ensembl.org/id/ENSBTAG00000018805" } ] } } ], "crossref": [ { "id": "E1BJ12", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018805", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018805", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533598", "url": "https://www.ncbi.nlm.nih.gov/gene/533598", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533598", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533598", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGFWVER", "url": "https://omabrowser.org/oma/group/AGFWVER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ12", "url": "https://www.orthodb.org/?gene=E1BJ12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179710", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ12", "url": "https://www.uniprot.org/uniprotkb/E1BJ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ12-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRASDSSFLGDVGFWVERTPVHEAAQRGETRQLQQLIESGACVNQVTVDSITPLHAASLQGQVQCVQLLLAAGAQVDARNIDGSTPLCDACASGSVECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIQFGGNIYARDNRGRKPSDYTWASSAPARCLEHYEKTPLSLSQLCRVSLRRAAGVRGLEKIARLDIPPRLIDFLSYN", "length": 278, "header": "tr|E1BJ12-1|E1BJ12_BOVIN Isoform 1 of Ankyrin repeat and SOCS box containing 13 OS=Bos taurus OX=9913 GN=ASB13 PE=3 SV=1 CANONICAL=E1BJ12-1" }, "isoforms": [ { "isoform_ac": "E1BJ12-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ12/entry#E1BJ12-1", "sequence": { "sequence": "MEPRASDSSFLGDVGFWVERTPVHEAAQRGETRQLQQLIESGACVNQVTVDSITPLHAASLQGQVQCVQLLLAAGAQVDARNIDGSTPLCDACASGSVECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIQFGGNIYARDNRGRKPSDYTWASSAPARCLEHYEKTPLSLSQLCRVSLRRAAGVRGLEKIARLDIPPRLIDFLSYN", "length": 278, "header": "tr|E1BJ12-1|E1BJ12_BOVIN Isoform 1 of Ankyrin repeat and SOCS box containing 13 OS=Bos taurus OX=9913 GN=ASB13 PE=3 SV=1 CANONICAL=E1BJ12-1" }, "locus": { "chromosome": "13", "start_pos": 43046537, "end_pos": 43031437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025032.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025032.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025032.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025032.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533598", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533598", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIT5-1", "protein_name": "Ankyrin repeat and SOCS box containing 13", "gene_name": "ASB13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPRTADGCFLGDVGFWVERTPVHEAAQRGETRQLQQLIESGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVDARNIDGSTPLCDACASGSVECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLVQFGGDIYARDNRGRKPSDYARSSSAPARCLEHYEKTPLTLSQLCRVSLRRATGVRGLEKIAKLNIPARLIEYLSYN", "length": 278 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XZ64-1", "protein_name": "Ankyrin repeat and SOCS box containing 13", "gene_name": "ASB13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCTFAERPLALTLHTQDQTKKKSELIPLYKPLNLPMERPEARLYAPCCVCDVLFPRGFWVDRTPVHEAARQGEILQLQQLIESGACVNAVTYDSITPLHEASLRGQTQCVKLLLAAGAQVDARNIDGSTPLCDACASGSIECVKVLLSHGAKVNPPLYTASPLHEACMNGSSDCVQLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKLLLKAGANVNAAKLHETALHHAAKVKNVDLVEMLIEFGGNIYARDNRGKKPSDYTLRSSPTAKCFEYYEKTPLSLSQLCRVTVRKAAGQRALEKIAKLNIPQRLIQYLSYN", "length": 320 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZEJ6-1", "protein_name": "Ankyrin repeat and SOCS box-containing 13", "gene_name": "Asb13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPRAGDRCFLGDVGFWVERTPVHEAAQRGESLQLQQLINSGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVDARNIDGSTPLCDACASGNVECVKLLLSYGAKVNPPLYTASPLHEACMSGNSDCVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIVMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVTLRKATGVRGLEKVAKLNIPPRLIDYLSYN", "length": 278 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FFH0-1", "protein_name": "Ankyrin repeat and SOCS box protein 13 isoform X1", "gene_name": "asb13b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEFEITRTRPSLFGDIAHGLGFWTDRSAVHEAAAQGRVVQLRKLIENGASVNIVAVDSITPLHEACIQGHTQCVKLLLDAGAHVDARNIDGSTPLCDACAAGSLECVKLLLEHGATVNPPLFTFSPLHEACMGGNSKCVQLMIDEGALMEAHDCHFGTPLHVACARQHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNLELIELLVEFGGNIFARDNLGKKPIQYTRSSSASALCLEFYESTPLSLQQLCRISLRNALGKRALGVFTQLGLPNRIIWFLSYLPAPPMELLQS", "length": 294 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GR75-1", "protein_name": "Ankyrin repeat and SOCS box protein 13", "gene_name": "Asb13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPRAGDGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVSLRKATGVRGLEKVAKLNIPPRLIDYLSYN", "length": 278 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8VBX0-1", "protein_name": "Ankyrin repeat and SOCS box protein 13", "gene_name": "Asb13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPRAGDGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIDSGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLSLSQLCRVSLRKATGVRGLEKVAKLNIPPRLIDYLSYN", "length": 278 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXK3-1", "protein_name": "Ankyrin repeat and SOCS box protein 13", "gene_name": "ASB13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN", "length": 278 }, "evidence": [ { "id": "E1BJ12", "url": "https://omabrowser.org/oma/group/E1BJ12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BJ12", "url": "https://www.uniprot.org/uniprotkb/E1BJ12" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BJ12", "url": "https://www.uniprot.org/uniprotkb/E1BJ12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ12" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 232, "end_pos": 278, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ16-1", "uniprot_ac": "E1BJ16", "uniprot_id": "E1BJ16_BOVIN", "mass": { "chemical_mass": 79263.0, "monoisotopic_mass": 79263.0 }, "refseq": { "ac": "XP_005227819", "name": "PWWP domain-containing DNA repair factor 3B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227819" }, "gene_names": [ { "name": "PWWP3B", "type": "recommended", "evidence": [ { "id": "E1BJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ16" } ] }, { "name": "PWWP3B", "type": "synonym", "evidence": [ { "id": "XP_005227819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227819" } ] } ], "protein_names": [ { "name": "PWWP domain containing 3B", "type": "synonym", "evidence": [ { "id": "E1BJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ16/entry#names_and_taxonomy" } ] }, { "name": "PWWP domain-containing DNA repair factor 3B", "type": "synonym", "evidence": [ { "id": "XP_005227819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227819" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ16", "url": "https://www.uniprot.org/uniprotkb/E1BJ16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PWWP3B", "url": "https://www.uniprot.org/uniprotkb/E1BJ16", "locus": { "chromosome": "X", "start_pos": 54948791, "end_pos": 54912689, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040132", "url": "https://www.ensembl.org/id/ENSBTAG00000040132" } ] } } ], "crossref": [ { "id": "ENSBTAG00000040132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06080", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06080", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539380", "url": "https://www.ncbi.nlm.nih.gov/gene/539380", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR035504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539380", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539380", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KYRKHEG", "url": "https://omabrowser.org/oma/group/KYRKHEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ16", "url": "https://www.orthodb.org/?gene=E1BJ16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31333:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31333:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20887", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20887", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227819", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227819", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ16", "url": "https://www.uniprot.org/uniprotkb/E1BJ16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ16-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAEYVLCNWQDQLWPAKVLSRSEASSNSKRKKVFSLEVQILSLDEKIQMESTETKILTKSQVEAIASSLATQSEVSDPPGEETAYARSLKMALDILNERTNLIQVSSSDEEETTILSQNIPQKPSDSPPRKKYRKHEGEGDLPKCLEENENSTILLVSSESDDSLDDDKSQVHAMIDNIPNETETKSSQNLSWCQTFPSLLEDEDEKESKKKIDLSILPLLSTIKEEDVYVKEEKFSPTLPSDGFIVPKALKEEPEDIYPEALAASSECSAFSENIEDPGEGPSDPCSVASQNQPTVESEMDAEAFPQPSSQEQQVSFSASSHSGDYSLLGSNERNLQRLDFEEFEEEFQASDKSARISSIAASILDDDEEDEELPRFLFNYEQRSFETGMIVWFKYQKYPFWPSVIKSIRRKERKASVVFVEANMNPEKRGVRVPFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADISYPVRKIIKQDTFRNLFPKLQNENTGGSMSVTSQTKKMSFQKLLPDRMKSARDRANKNLVDFIVNAKGTESHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEVYKQIDEKMLTRIRNDKIKFILEVLLPEAIICSISAVDGLDYKAAEAKYLKGPSLGYRERELFDSKILFEKRRKPLTKEDH", "length": 694, "header": "tr|E1BJ16-1|E1BJ16_BOVIN Isoform 1 of PWWP domain containing 3B OS=Bos taurus OX=9913 GN=PWWP3B PE=3 SV=2 CANONICAL=E1BJ16-1" }, "isoforms": [ { "isoform_ac": "E1BJ16-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ16/entry#E1BJ16-1", "sequence": { "sequence": "MDAEYVLCNWQDQLWPAKVLSRSEASSNSKRKKVFSLEVQILSLDEKIQMESTETKILTKSQVEAIASSLATQSEVSDPPGEETAYARSLKMALDILNERTNLIQVSSSDEEETTILSQNIPQKPSDSPPRKKYRKHEGEGDLPKCLEENENSTILLVSSESDDSLDDDKSQVHAMIDNIPNETETKSSQNLSWCQTFPSLLEDEDEKESKKKIDLSILPLLSTIKEEDVYVKEEKFSPTLPSDGFIVPKALKEEPEDIYPEALAASSECSAFSENIEDPGEGPSDPCSVASQNQPTVESEMDAEAFPQPSSQEQQVSFSASSHSGDYSLLGSNERNLQRLDFEEFEEEFQASDKSARISSIAASILDDDEEDEELPRFLFNYEQRSFETGMIVWFKYQKYPFWPSVIKSIRRKERKASVVFVEANMNPEKRGVRVPFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADISYPVRKIIKQDTFRNLFPKLQNENTGGSMSVTSQTKKMSFQKLLPDRMKSARDRANKNLVDFIVNAKGTESHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEVYKQIDEKMLTRIRNDKIKFILEVLLPEAIICSISAVDGLDYKAAEAKYLKGPSLGYRERELFDSKILFEKRRKPLTKEDH", "length": 694, "header": "tr|E1BJ16-1|E1BJ16_BOVIN Isoform 1 of PWWP domain containing 3B OS=Bos taurus OX=9913 GN=PWWP3B PE=3 SV=2 CANONICAL=E1BJ16-1" }, "locus": { "chromosome": "X", "start_pos": 54946903, "end_pos": 54944822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101860.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539380", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539380", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B5DEG0-1", "protein_name": "PWWP domain containing 3B", "gene_name": "Pwwp3b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDGEYVLCSWKDQLWPAKVLDRSESPSDSKRKKTLSVEVEILSLDEKITVESKDTKVLTKSAVEAIMSSLTVQSEVSFTPTEETAYERSLKMALEIVEERTNQSHESMAEEQHMATASENVPQQPPDSPPHKKFRKLESNLQEDSASMLLCSESDDSLSDEKLQVHTTSENMPSEVEMKSENLSCCQTYPSFSDDDDKKEEKKKIDISAIMSVNLSLKEESEFIKEEKFVPSSEDLAVPKEESQDILPDAPAVSSECFIVSENNMEDPGEGPSNQNPGSYGSQSQSTVESDVGAETSTAGCSGDYQVSLPARDTVNSDLLLQRLDLEDLEEEARASGKLLSLNPACAAALENDDEDDDEDLPRFILRYETRAFETGMIVWFKYQKYPFWPAVIKSIRRKERKASVLLVEADMNPQKRGVRVSLRRLKKYDCKEKQALVEKAREEYKESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADISYPVRKIIKQDTFRNIFPKLYNEDAGEQLPVASHAKRVSFRKILPDRMKPARDRANKNLVDFIVNAKGTEDHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEIYKQIDQKMLTLIKDDKIKFVLEVLLPEAIICSISAVDGLDYEAAEAKYLKGPSLGYRERELYDSKILFEKRRRSLPNEGR", "length": 679 }, "evidence": [ { "id": "E1BJ16", "url": "https://omabrowser.org/oma/group/E1BJ16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RXM4-1", "protein_name": "PWWP domain containing 3B", "gene_name": "PWWP3B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAEYVLCNWQDQLWPAKVLSRSEASSNSKRKKTFSLEVQILLLDEKIKVESTETKILNKSQVEAIVSSLAAESEASDPPREETAYGRALKAALDILNERTNLIQASSSDEEENPTLSQNALQKLSDSPPHKKYRKHEGDLPKCLEENENPPSLLVSSESDDSLSDDKSQVRAIIDAIPSEMETKSSQDFSWCQTFPSLSEDEEEKESKKKIDISAVMPLHSTIKEEDVCVKEEKFSPPLPLDYFTVPKALKEEAEDICPEAPAISSECSTFTENIEDPGEGPSNPCSGTSQNQPTVESETGACARPSSWECQVSLSASSRAMDYSLLLGNNERNLQRLDFEDLGEERQASDKSVHVSSIDASILDDNEEDEELPRFLFHYEPRSFETGMIVWFKYQKYPFWPAVVKSIRRKERKASVLFVEANMNPEKRGIRVPFRRLKKFDCKEKQALVDQAREEYSESIDWCISLICDYRVRIGCGSFAGSFLEYYAADISYPLRKVIKQDTFRNLFPKLQNENPTESMVVTSQTKKMSFQKILPDRMKSARDRANKNLVDFIVNAKGTESHLLAILKGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEIYKQIDEKMLTLIRDDKIKFILEVLLPEAIICSISAVDGLDYKAAEAKYLKGPSLGYRERELFDAKIIFEKRRKPLTNEAR", "length": 692 }, "evidence": [ { "id": "E1BJ16", "url": "https://omabrowser.org/oma/group/E1BJ16/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4VA55-1", "protein_name": "PWWP domain-containing DNA repair factor 3B", "gene_name": "Pwwp3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDGKYVLCNWKDQLWPAKVLDRSESPSESKRKNTSSLEVEILSLDEKITVESTDTKVLSKSAVEAIMSSLAVQSEVIIAPREETAYERSLKMALEMVKEGTNLSQESMSEEQPTATASENVPEQPPDSPPHKKFRKLESNTQEDSASILLCSESDDSMTDDKLQVHTTGESMPSEMDTKATENLGCCQTDPSLADEDDKKEEKKKIDISAIMSVNLSLKEESEYIKEEKFVPSSEDLTVPKEESQDILPEAPLAVSSECSIVSENNMEDPGEGPSNQNLVSYANQNQSSVESDVGAETSTAGCSGDFQVSLPTRDTVSSDLLLQRLDLEDLEEEARASGKLLSLNPASAAALENDNEDDDEDLPRFILHYETRAFETGMIVWFKYQKYPFWPAVIKSIRRKERKASVLLVEADMSPQKKGVRVSLRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADISYPVRKIIKQDTFRNIFPKLYNENVGEQLPMASQAKRVSFQKILPDRMKPARDRANKNLVDFIVNAKGTEDHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEIYKQIDQKMLTLIKDDKIKFVLEVLLPEAIICSISAVDGLDYEAAEAKYLKGPSLGCRERELYDSKILFEKRRRSLPNEGH", "length": 681 }, "evidence": [ { "id": "E1BJ16", "url": "https://omabrowser.org/oma/group/E1BJ16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5H9M0-1", "protein_name": "PWWP domain-containing DNA repair factor 3B", "gene_name": "PWWP3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESEYVLCNWKDQLWPAKVLSRSETSSNSKRKKAFSLEVQILSLDEKIKLDSTETKILNKSQIEAIAASLGLQSEDSAPPTEETAYGRSLKVALGILNERTNLSQASTSDEEEITMLSQNVPQKQSDSPPHKKYRKDEGDLPGCLEERENSACLLASSESDDSLYDDKSQAPTMVDTIPSEVETKSLQNSSWCETFPSLSEDNDEKENKNKIDISAVMSVHSAVKEESACVKDEKFAPPLSPLSSDMLIMPKALKEESEDTCLETLAVPSECSAFSENIEDPGEGPSNPCLDTSQNQPSMESEMGAAACPGSCSRECEVSFSASNPVWDYSHLMSSERNFQRLDFEELEEEGQASDKSLLPSRINLSLLDDDEEDEELPRFILHYETHPFETGMIVWFKYQKYPFWPAVIKSIRRKERKASVLFVEANMNSEKKGIRVNFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADISYPVRKETKQDTFRNKFPKLHNEDAREPMAVTSQTKKMSFQKILPDRMKAARDRANKNLVDFIVNAKGTENHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEVCNQIDQIMPTWIKDDKIKFILEVLLPEAIICSISAVDGLDYEAAEAKYLKGPCLGYRERELFDAKIIYEKRRKAPTNEAH", "length": 696 }, "evidence": [ { "id": "E1BJ16", "url": "https://omabrowser.org/oma/group/E1BJ16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ16" }, { "id": "PF20884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MUM1-like PWWP", "eco_id": "ECO_0000259", "start_pos": 388, "end_pos": 467, "start_aa": "Phe", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ16" }, { "id": "PF20887", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20887" }, { "id": "PF20886", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PWWP", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 99, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 191, "end_pos": 193 }, { "start_pos": 573, "end_pos": 575 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ20-1", "uniprot_ac": "E1BJ20", "uniprot_id": "E1BJ20_BOVIN", "mass": { "chemical_mass": 13196.0, "monoisotopic_mass": 13196.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Elongin-B", "type": "recommended", "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#names_and_taxonomy" } ] }, { "name": "Elongin 18 kDa subunit", "type": "synonym", "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#names_and_taxonomy" } ] }, { "name": "RNA polymerase II transcription factor SIII subunit B", "type": "synonym", "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#names_and_taxonomy" } ] }, { "name": "SIII p18", "type": "synonym", "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#names_and_taxonomy" } ] }, { "name": "Transcription elongation factor B polypeptide 2", "type": "synonym", "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20#function" }, { "database": "UniProtKB", "id": "ARBA00054216", "url": "https://www.uniprot.org/uniprotkb/ARBA00054216#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BJ20", "locus": {} } ], "crossref": [ { "id": "E1BJ20", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027787", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027787", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EDQMLFK", "url": "https://omabrowser.org/oma/group/EDQMLFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13248:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13248:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ20-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVFLMIRRHKTTIFTDAKELSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADEAFEALRIEPFSSPPELPDVMKPQDSGSSANEQAVQ", "length": 118, "header": "tr|E1BJ20-1|E1BJ20_BOVIN Isoform 1 of Elongin-B OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BJ20-1" }, "isoforms": [ { "isoform_ac": "E1BJ20-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ20/entry#E1BJ20-1", "sequence": { "sequence": "MDVFLMIRRHKTTIFTDAKELSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADEAFEALRIEPFSSPPELPDVMKPQDSGSSANEQAVQ", "length": 118, "header": "tr|E1BJ20-1|E1BJ20_BOVIN Isoform 1 of Elongin-B OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BJ20-1" }, "locus": { "chromosome": "18", "start_pos": 65442555, "end_pos": 65442202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013247.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013247.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048590.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048590.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZTT3-1", "protein_name": "Elongin-B", "gene_name": "ENSRNOG00000066836", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "GKPFQCPQSFCQLDSNCHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQQLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDSFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ", "length": 126 }, "evidence": [ { "id": "E1BJ20", "url": "https://omabrowser.org/oma/group/E1BJ20/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "VCB complex", "id": "GO:0030891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030891", "evidence": [ { "database": "UniProtKB", "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20" } ], "pmid": "" }, { "name": "elongin complex", "id": "GO:0070449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070449", "evidence": [ { "database": "UniProtKB", "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "E1BJ20", "url": "https://www.uniprot.org/uniprotkb/E1BJ20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ20-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 118, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ20-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ20" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ20" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 66, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ48-1", "uniprot_ac": "E1BJ48", "uniprot_id": "E1BJ48_BOVIN", "mass": { "chemical_mass": 48497.0, "monoisotopic_mass": 48497.0 }, "refseq": {}, "gene_names": [ { "name": "PHF24", "type": "recommended", "evidence": [ { "id": "E1BJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" } ] } ], "protein_names": [ { "name": "PHD finger protein 24", "type": "synonym", "evidence": [ { "id": "E1BJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ48", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF24", "url": "https://www.uniprot.org/uniprotkb/E1BJ48", "locus": { "chromosome": "8", "start_pos": 59266671, "end_pos": 59246279, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012809", "url": "https://www.ensembl.org/id/ENSBTAG00000012809" } ] } } ], "crossref": [ { "id": "E1BJ48", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012809", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012809", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJ48", "url": "https://www.orthodb.org/?gene=E1BJ48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46453:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46453:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16744", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16744", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJ48", "url": "https://www.uniprot.org/uniprotkb/E1BJ48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ48-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDYTVHGILQARILERVAFPFSRGSSQPRAMGVLMSKRQTVEQVQKVSLAVSAFKDGLRDRPSIRRTGELPGSRRGTVEGSVQEVQEEKEAEASAPALQEESSVNRASWERLRDGRGVEPEEFDRTSHFTPPAFIRPTRKLDDDKPPDIRLEPREPVVNDEMCDVCEVWTAESLFPCRVCTRVFHDGCLRRMGYIQGDSAAEVTETAHTETGWSCHYCDNLNLLLTEEEMYSLTETFQQCKVIPDCSLTLEDFLRYRHQTAKRGNSDRALSEEQEEQAARQFAALDPEHRGHVEWPDFLSHESLLLLQQLRPQNSLLRLLTVKERERARATFLARGSGSTISEAECHRAQHSWFCKRPIEAPSCSVSVSHVGPIADSSPASSSSKSQDKAPLPTEPESRFVDWPTFLQESVIYILAARPNSLAIHLKPPG", "length": 430, "header": "tr|E1BJ48-1|E1BJ48_BOVIN Isoform 1 of PHD finger protein 24 OS=Bos taurus OX=9913 GN=PHF24 PE=4 SV=2 CANONICAL=E1BJ48-1" }, "isoforms": [ { "isoform_ac": "E1BJ48-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ48/entry#E1BJ48-1", "sequence": { "sequence": "MDYTVHGILQARILERVAFPFSRGSSQPRAMGVLMSKRQTVEQVQKVSLAVSAFKDGLRDRPSIRRTGELPGSRRGTVEGSVQEVQEEKEAEASAPALQEESSVNRASWERLRDGRGVEPEEFDRTSHFTPPAFIRPTRKLDDDKPPDIRLEPREPVVNDEMCDVCEVWTAESLFPCRVCTRVFHDGCLRRMGYIQGDSAAEVTETAHTETGWSCHYCDNLNLLLTEEEMYSLTETFQQCKVIPDCSLTLEDFLRYRHQTAKRGNSDRALSEEQEEQAARQFAALDPEHRGHVEWPDFLSHESLLLLQQLRPQNSLLRLLTVKERERARATFLARGSGSTISEAECHRAQHSWFCKRPIEAPSCSVSVSHVGPIADSSPASSSSKSQDKAPLPTEPESRFVDWPTFLQESVIYILAARPNSLAIHLKPPG", "length": 430, "header": "tr|E1BJ48-1|E1BJ48_BOVIN Isoform 1 of PHD finger protein 24 OS=Bos taurus OX=9913 GN=PHF24 PE=4 SV=2 CANONICAL=E1BJ48-1" }, "locus": { "chromosome": "8", "start_pos": 59265667, "end_pos": 59254922, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017015.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017015.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017015.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017015.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BJ48", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJ48", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1BJ48", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ48-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 430, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ48-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ48" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ48" }, { "id": "PF16744", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16744" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KIAA1045 RING finger", "eco_id": "ECO_0000259", "start_pos": 156, "end_pos": 228, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ55-1", "uniprot_ac": "E1BJ55", "uniprot_id": "E1BJ55_BOVIN", "mass": { "chemical_mass": 20966.0, "monoisotopic_mass": 20966.0 }, "refseq": { "ac": "NP_001179293", "name": "zinc finger protein 428", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179293" }, "gene_names": [ { "name": "ZNF428", "type": "recommended", "evidence": [ { "id": "E1BJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ55" } ] }, { "name": "ZNF428", "type": "synonym", "evidence": [ { "id": "NP_001179293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179293" } ] } ], "protein_names": [ { "name": "Zinc finger protein 428", "type": "synonym", "evidence": [ { "id": "E1BJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ55/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 428", "type": "synonym", "evidence": [ { "id": "NP_001179293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179293" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ55", "url": "https://www.uniprot.org/uniprotkb/E1BJ55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF428", "url": "https://www.uniprot.org/uniprotkb/E1BJ55", "locus": { "chromosome": "18", "start_pos": 51828235, "end_pos": 51838230, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012796", "url": "https://www.ensembl.org/id/ENSBTAG00000012796" } ] } } ], "crossref": [ { "id": "E1BJ55", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012796", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012796", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540173", "url": "https://www.ncbi.nlm.nih.gov/gene/540173", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540173", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540173", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EGGAYHC", "url": "https://omabrowser.org/oma/group/EGGAYHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ55", "url": "https://www.orthodb.org/?gene=E1BJ55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36862", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36862", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36862:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36862:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179293", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ55", "url": "https://www.uniprot.org/uniprotkb/E1BJ55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ55-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTETREPAETGGYASLEEDDEDLSPGPEHSSDSEYTLSEPDSEEEDEEEEEEEETTDDPEYDPGYKVKQRLGGGRGGPSRRAPRAAQPPGPPAQPCQLCGRSPLGEAPPGTPPCRLCCPAVAPQEAPAPETRALGEEEGGAPRAGEGRPTGRDEEDEEEEEEEEGTYHCTECEDSFDSLGELHGHFMLHARGEV", "length": 194, "header": "tr|E1BJ55-1|E1BJ55_BOVIN Isoform 1 of Zinc finger protein 428 OS=Bos taurus OX=9913 GN=ZNF428 PE=4 SV=1 CANONICAL=E1BJ55-1" }, "isoforms": [ { "isoform_ac": "E1BJ55-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ55/entry#E1BJ55-1", "sequence": { "sequence": "MTETREPAETGGYASLEEDDEDLSPGPEHSSDSEYTLSEPDSEEEDEEEEEEEETTDDPEYDPGYKVKQRLGGGRGGPSRRAPRAAQPPGPPAQPCQLCGRSPLGEAPPGTPPCRLCCPAVAPQEAPAPETRALGEEEGGAPRAGEGRPTGRDEEDEEEEEEEEGTYHCTECEDSFDSLGELHGHFMLHARGEV", "length": 194, "header": "tr|E1BJ55-1|E1BJ55_BOVIN Isoform 1 of Zinc finger protein 428 OS=Bos taurus OX=9913 GN=ZNF428 PE=4 SV=1 CANONICAL=E1BJ55-1" }, "locus": { "chromosome": "18", "start_pos": 51834845, "end_pos": 51829183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017001.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017001.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017001.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017001.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 111, "start_aa": "Thr", "end_pos": 111, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr111", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540173", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540173", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K1B1-1", "protein_name": "Zinc finger protein 428", "gene_name": "Zfp428", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTETREPTETGGYASLEEDDEDLSPEPDSEEEEEEEEEEETTDDPEYDPGYKVKQRIGGGRGGPSRRAPRATQPAGPPAQPCQLCGRSALGEAPPGTPPCRLCCPATATQEAPAPESRALGEEEEEPSRTGENRPAGRDGDEDEDEGGTYHCTECEDSFDNLGELHGHFMLHARGEV", "length": 177 }, "evidence": [ { "id": "E1BJ55", "url": "https://omabrowser.org/oma/group/E1BJ55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C1M2-1", "protein_name": "Zinc finger protein 428", "gene_name": "Znf428", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTETREPTETGGYASLEEDDEDLSPEPDSEEEEEEEEEETTDDPEYDPGYKVKQRIGGGRGGPSRRAPRATQPAGPPAQPCQLCGRSALGEAPPGTPPCRLCCPATATQEAPGPESRALGEEEEEPSRTGETRPAGRDGDEDEEEGGTYHCTECEDSFDNLGELHGHFMLHARGEV", "length": 176 }, "evidence": [ { "id": "E1BJ55", "url": "https://omabrowser.org/oma/group/E1BJ55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96B54-1", "protein_name": "Zinc finger protein 428", "gene_name": "ZNF428", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTETREPAETGGYASLEEDDEDLSPGPEHSSDSEYTLSEPDSEEEEDEEEEEEETTDDPEYDPGYKVKQRLGGGRGGPSRRAPRAAQPPAQPCQLCGRSPLGEAPPGTPPCRLCCPATAPQEAPAPEGRALGEEEEEPPRAGEGRPAGREEEEEEEEEGTYHCTECEDSFDNLGELHGHFMLHARGEV", "length": 188 }, "evidence": [ { "id": "E1BJ55", "url": "https://omabrowser.org/oma/group/E1BJ55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BJ55", "url": "https://www.uniprot.org/uniprotkb/E1BJ55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ55-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ55-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ55" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ55" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 167, "end_pos": 194, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 111 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ58-1", "uniprot_ac": "E1BJ58", "uniprot_id": "E1BJ58_BOVIN", "mass": { "chemical_mass": 35372.0, "monoisotopic_mass": 35372.0 }, "refseq": { "ac": "NP_001377637", "name": "olfactory receptor family 2 subfamily T member 61", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637" }, "gene_names": [ { "name": "OR2T61", "type": "recommended", "evidence": [ { "id": "E1BJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ] }, { "name": "OR2T61", "type": "synonym", "evidence": [ { "id": "NP_001377637", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 2 subfamily T member 61", "type": "synonym", "evidence": [ { "id": "E1BJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ58/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 56", "type": "synonym", "evidence": [ { "id": "NP_001377637", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637" } ] }, { "name": "olfactory receptor family 2 subfamily T member 61", "type": "synonym", "evidence": [ { "id": "NP_001377637", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2T61", "url": "https://www.uniprot.org/uniprotkb/E1BJ58", "locus": { "chromosome": "7", "start_pos": 40218516, "end_pos": 40219466, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039706", "url": "https://www.ensembl.org/id/ENSBTAG00000039706" } ] } } ], "crossref": [ { "id": "E1BJ58", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ58", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337324", "url": "https://www.ncbi.nlm.nih.gov/gene/100337324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337324", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MYMRPIS", "url": "https://omabrowser.org/oma/group/MYMRPIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ58", "url": "https://www.orthodb.org/?gene=E1BJ58", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377637", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ58-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ58-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALMKNQTHISHFILLGLFNHTPLHLLLFSIIMVMFLVALSGNGLMILLINTDSRLHSPIYFFLSWLSLMDLTLISTSVPRMAIDYLLGHGSISFTGCGLQILFFVTLLGDECFLLAFMAYDRYVAISNPLRYSVVMSCRVCWLMVALCWLSGLVDGLIQAIYTLSFPYCGSQEIDHFFCDIPAVLKLACADTSLYQTMIYVCCVIMLLLPFSVISVSYLLIFVTVLRMHSAEGQKKAFATCSSHMAVVSLFYGAAMIAYMRPQTYHSSKQDKVVSAFYTMITPMLNPLIYSLRNKEVAGALKKLLGRCPCGGRQE", "length": 316, "header": "tr|E1BJ58-1|E1BJ58_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily T member 61 OS=Bos taurus OX=9913 GN=OR2T61 PE=3 SV=3 CANONICAL=E1BJ58-1" }, "isoforms": [ { "isoform_ac": "E1BJ58-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ58/entry#E1BJ58-1", "sequence": { "sequence": "MALMKNQTHISHFILLGLFNHTPLHLLLFSIIMVMFLVALSGNGLMILLINTDSRLHSPIYFFLSWLSLMDLTLISTSVPRMAIDYLLGHGSISFTGCGLQILFFVTLLGDECFLLAFMAYDRYVAISNPLRYSVVMSCRVCWLMVALCWLSGLVDGLIQAIYTLSFPYCGSQEIDHFFCDIPAVLKLACADTSLYQTMIYVCCVIMLLLPFSVISVSYLLIFVTVLRMHSAEGQKKAFATCSSHMAVVSLFYGAAMIAYMRPQTYHSSKQDKVVSAFYTMITPMLNPLIYSLRNKEVAGALKKLLGRCPCGGRQE", "length": 316, "header": "tr|E1BJ58-1|E1BJ58_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily T member 61 OS=Bos taurus OX=9913 GN=OR2T61 PE=3 SV=3 CANONICAL=E1BJ58-1" }, "locus": { "chromosome": "7", "start_pos": 40219466, "end_pos": 40218519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052929.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052929.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050486.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050486.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100337324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337324", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BJ58", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ58-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ58-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ58" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ58" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 291, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 20, "end_pos": 22 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ68-1", "uniprot_ac": "E1BJ68", "uniprot_id": "E1BJ68_BOVIN", "mass": { "chemical_mass": 14722.0, "monoisotopic_mass": 14722.0 }, "refseq": {}, "gene_names": [ { "name": "INSL5", "type": "recommended", "evidence": [ { "id": "E1BJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ] } ], "protein_names": [ { "name": "Insulin-like peptide INSL5", "type": "recommended", "evidence": [ { "id": "E1BJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ68/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68#function" }, { "database": "UniProtKB", "id": "ARBA00056758", "url": "https://www.uniprot.org/uniprotkb/ARBA00056758#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INSL5", "url": "https://www.uniprot.org/uniprotkb/E1BJ68", "locus": { "chromosome": "3", "start_pos": 78523226, "end_pos": 78517128, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003850", "url": "https://www.ensembl.org/id/ENSBTAG00000003850" } ] } } ], "crossref": [ { "id": "E1BJ68", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003850", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJ68", "url": "https://www.orthodb.org/?gene=E1BJ68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20968:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20968:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ68-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VESLKCQTAFYSPEARREGSRKLCGSEYVRTVIYICASSRWRRHAGALLQGQQAERGNHFQLPNEQEISEERAAHNLPKMDFAGEESLQGEQLPTEGLWRSKKHLVMSRQDLQTLCCTEGCSMSDLSTLC", "length": 130, "header": "tr|E1BJ68-1|E1BJ68_BOVIN Isoform 1 of Insulin-like peptide INSL5 OS=Bos taurus OX=9913 GN=INSL5 PE=3 SV=4 CANONICAL=E1BJ68-1" }, "isoforms": [ { "isoform_ac": "E1BJ68-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ68/entry#E1BJ68-1", "sequence": { "sequence": "VESLKCQTAFYSPEARREGSRKLCGSEYVRTVIYICASSRWRRHAGALLQGQQAERGNHFQLPNEQEISEERAAHNLPKMDFAGEESLQGEQLPTEGLWRSKKHLVMSRQDLQTLCCTEGCSMSDLSTLC", "length": 130, "header": "tr|E1BJ68-1|E1BJ68_BOVIN Isoform 1 of Insulin-like peptide INSL5 OS=Bos taurus OX=9913 GN=INSL5 PE=3 SV=4 CANONICAL=E1BJ68-1" }, "locus": { "chromosome": "3", "start_pos": 78522952, "end_pos": 78517329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005022.4", "url": "https://www.ensembl.org/id/ENSBTAT00000005022.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005022.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005022.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of feeding behavior", "id": "GO:2000253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000253", "evidence": [ { "database": "UniProtKB", "id": "E1BJ68", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 130, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ68" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ68" }, { "id": "SM00078", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00078" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Insulin-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 130, "start_aa": "Arg", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ72-1", "uniprot_ac": "E1BJ72", "uniprot_id": "E1BJ72_BOVIN", "mass": { "chemical_mass": 27788.0, "monoisotopic_mass": 27788.0 }, "refseq": { "ac": "NP_001192913", "name": "kallikrein-9 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913" }, "gene_names": [ { "name": "KLK9", "type": "recommended", "evidence": [ { "id": "E1BJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ] }, { "name": "KLK9", "type": "synonym", "evidence": [ { "id": "NP_001192913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913" } ] }, { "name": "KLNF", "type": "synonym", "evidence": [ { "id": "NP_001192913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913" } ] } ], "protein_names": [ { "name": "tissue kallikrein", "type": "recommended", "evidence": [ { "id": "E1BJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ72/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.35", "type": "synonym", "evidence": [ { "id": "E1BJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ72/entry#names_and_taxonomy" } ] }, { "name": "kallikrein F", "type": "synonym", "evidence": [ { "id": "NP_001192913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913" } ] }, { "name": "kallikrein-9 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLK9", "url": "https://www.uniprot.org/uniprotkb/E1BJ72", "locus": { "chromosome": "18", "start_pos": 56979170, "end_pos": 56986609, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040177", "url": "https://www.ensembl.org/id/ENSBTAG00000040177" } ] } } ], "crossref": [ { "id": "ENSBTAG00000040177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530795", "url": "https://www.ncbi.nlm.nih.gov/gene/530795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530795", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCRWAYP", "url": "https://omabrowser.org/oma/group/LCRWAYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ72", "url": "https://www.orthodb.org/?gene=E1BJ72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192913", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ72-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLGFLCALLSLLEGQGWADTRAIGAKECRPNSQPWQAGLFYLTHLFCGATLISDRWLLTAAHCRKRYLWVRLGEHHLWKWEGPEQLFRATDFFPHPGFNQDLTAQDHNNDIMLVRLPRKAHLGPAVQPLNLSQTCVSPGTQCLISGWGAVSSPKVEYPLTLQCANISILEPRLCRRAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYTSVCHYLDWIQETMEDN", "length": 251, "header": "tr|E1BJ72-1|E1BJ72_BOVIN Isoform 1 of tissue kallikrein OS=Bos taurus OX=9913 GN=KLK9 PE=3 SV=3 CANONICAL=E1BJ72-1" }, "isoforms": [ { "isoform_ac": "E1BJ72-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ72/entry#E1BJ72-1", "sequence": { "sequence": "MRLGFLCALLSLLEGQGWADTRAIGAKECRPNSQPWQAGLFYLTHLFCGATLISDRWLLTAAHCRKRYLWVRLGEHHLWKWEGPEQLFRATDFFPHPGFNQDLTAQDHNNDIMLVRLPRKAHLGPAVQPLNLSQTCVSPGTQCLISGWGAVSSPKVEYPLTLQCANISILEPRLCRRAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYTSVCHYLDWIQETMEDN", "length": 251, "header": "tr|E1BJ72-1|E1BJ72_BOVIN Isoform 1 of tissue kallikrein OS=Bos taurus OX=9913 GN=KLK9 PE=3 SV=3 CANONICAL=E1BJ72-1" }, "locus": { "chromosome": "18", "start_pos": 56986261, "end_pos": 56980174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053012.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053012.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050470.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050470.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:530795", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530795", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZW13-1", "protein_name": "tissue kallikrein", "gene_name": "KLK9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLGFVWALLSLLAGHGWADTRTIGAEECRPNSQPWQAGLFYLTHLFCGATLISDRWLLTAAHCRKRHLWVRLGEHHLWKWEGPEQLFRATDFFPHPGFNQDLSAQDHNDDIMLIRLPRKANLGPTVQPLNLSQTCFSPGTQCLISGWGAVSSPKVQYPLTLQCANISILEPKLCHQAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPQRPAVYTSVCRYLDWIRKTMEDN", "length": 251 }, "evidence": [ { "id": "E1BJ72", "url": "https://omabrowser.org/oma/group/E1BJ72/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I4R5-1", "protein_name": "Kallikrein-9", "gene_name": "LOC100752653", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLGLTLVLLSLLAGHCGADTRAVGARECQRNSQPWQAGLFYLTRQLCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWQWEGPEKLLLATDFFPHPGFNSDLSANDHNDDIMLIRLPRKVQMSAAVQPLNLSQSLPTVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNRLCRWAYPGHISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSEPCSRPQRPAVYTSVCHYRDWVQKTMEEN", "length": 251 }, "evidence": [ { "id": "E1BJ72", "url": "https://omabrowser.org/oma/group/E1BJ72/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V934-1", "protein_name": "Kallikrein related-peptidase 9", "gene_name": "Klk9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLGLTLVLFSLLAGHCGADTRAVGARECQRNSQPWQAGLFYLTRQLCGATLINDQWLLTAAHCRKPYLWVRLGEHHLWQWEGPEKLLLVTDFFPHPGFNPDLSANDHNDDIMLIRLPRKVRLSPAVQPLNLSQSLPSVGTQCLISGWGSVSSSKIQFPMTLQCANISILDNKLCRWAYPGHISEKMLCAGLWEGGRGSCQGDSGGPLVCKGTLAGIVSGGSEPCSRPQRPAVYTSVFHYLDWIENTVEKYNHTNKLI", "length": 258 }, "evidence": [ { "id": "E1BJ72", "url": "https://omabrowser.org/oma/group/E1BJ72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UKQ9-1", "protein_name": "Kallikrein-9", "gene_name": "KLK9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLTRLFCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYTSVCHYLDWIQEIMEN", "length": 250 }, "evidence": [ { "id": "E1BJ72", "url": "https://omabrowser.org/oma/group/E1BJ72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "E1BJ72", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ72" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 249, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.35", "ec_name": "Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.", "evidence": [ { "id": "3.4.21.35", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.35" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 211, "end_pos": 213 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ78-1", "uniprot_ac": "E1BJ78", "uniprot_id": "E1BJ78_BOVIN", "mass": { "chemical_mass": 34900.0, "monoisotopic_mass": 34900.0 }, "refseq": {}, "gene_names": [ { "name": "LOC783020", "type": "recommended", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ] } ], "protein_names": [ { "name": "Sulfotransferase", "type": "recommended", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ78", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC783020", "url": "https://www.uniprot.org/uniprotkb/E1BJ78", "locus": {} } ], "crossref": [ { "id": "E1BJ78", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032051", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032051", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ECKNNAK", "url": "https://omabrowser.org/oma/group/ECKNNAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ78", "url": "https://www.orthodb.org/?gene=E1BJ78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "70607", "url": "https://www.rhea-db.org/rhea/70607", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJ78", "url": "https://www.uniprot.org/uniprotkb/E1BJ78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ78-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEALKSESMSRVAVDYVEGILQPKPTCDTWDQIWSFQARPDDLLISTYPKAGTTWTQEIVDLIQNGGDVNQSQRAPTHERFPFIEWIIPSLGSGLEQANAMASPRMLKTHLPFHLLPPSFLEENCKMIYVARNPKDNMVSYYHFHRMNRNLPAPGTWEEYFESFLAGKVCWGSWYDHVKGWWQAKDQHRILYLFYEDMKENPKHEIQKLAEFIGKSLDDKVLDKIVDHTSFSVMKQNPMANYTSIPNEYMNQLISPFMRKGVVGDWKNHFTVAQNERFDDDYRKNMADTTLTLHFRFS", "length": 298, "header": "tr|E1BJ78-1|E1BJ78_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=LOC783020 PE=3 SV=2 CANONICAL=E1BJ78-1" }, "isoforms": [ { "isoform_ac": "E1BJ78-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ78/entry#E1BJ78-1", "sequence": { "sequence": "MEALKSESMSRVAVDYVEGILQPKPTCDTWDQIWSFQARPDDLLISTYPKAGTTWTQEIVDLIQNGGDVNQSQRAPTHERFPFIEWIIPSLGSGLEQANAMASPRMLKTHLPFHLLPPSFLEENCKMIYVARNPKDNMVSYYHFHRMNRNLPAPGTWEEYFESFLAGKVCWGSWYDHVKGWWQAKDQHRILYLFYEDMKENPKHEIQKLAEFIGKSLDDKVLDKIVDHTSFSVMKQNPMANYTSIPNEYMNQLISPFMRKGVVGDWKNHFTVAQNERFDDDYRKNMADTTLTLHFRFS", "length": 298, "header": "tr|E1BJ78-1|E1BJ78_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=LOC783020 PE=3 SV=2 CANONICAL=E1BJ78-1" }, "locus": { "chromosome": "11", "start_pos": 44872780, "end_pos": 44862419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045471.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045471.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042859.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042859.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "O75897-1", "protein_name": "Sulfotransferase 1C4", "gene_name": "SULT1C4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHFQF", "length": 302 }, "evidence": [ { "id": "E1BJ78", "url": "https://omabrowser.org/oma/group/E1BJ78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sulfation", "id": "GO:0051923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051923", "evidence": [ { "database": "UniProtKB", "id": "E1BJ78", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aryl sulfotransferase activity", "id": "GO:0004062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004062", "evidence": [ { "database": "UniProtKB", "id": "E1BJ78", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJ78", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "70607", "name": "", "equation": "4-ethylphenol + 3'-phosphoadenylyl sulfate = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T0Y3-1", "P50227-1", "P19217-1", "A0AAA9RW31-1", "A0A3Q1N4J6-1", "F1MZX9-1", "E1BG19-1", "E1BAC7-1", "E1BIS9-1", "A0ABI0NTS0-1", "A0AAA9SGU9-1", "A0ABI0P531-1", "E1BJ78-1" ], "evidence": [ { "id": "70607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70607" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1N4J6", "gene_name": "", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1N4J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4J6" } ] } ] }, { "uniprot_ac": "A0AAA9RW31", "gene_name": "LOC100300896", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9RW31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW31" } ] } ] }, { "uniprot_ac": "A0AAA9SGU9", "gene_name": "LOC514658", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ] } ] }, { "uniprot_ac": "A0ABI0NTS0", "gene_name": "SULT1C2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0NTS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTS0" } ] } ] }, { "uniprot_ac": "A0ABI0P531", "gene_name": "LOC112446736", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0P531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P531" } ] } ] }, { "uniprot_ac": "E1BAC7", "gene_name": "SULT1D1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BAC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAC7" } ] } ] }, { "uniprot_ac": "E1BG19", "gene_name": "SULT2A1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BG19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG19" } ] } ] }, { "uniprot_ac": "E1BIS9", "gene_name": "SULT1C3", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIS9" } ] } ] }, { "uniprot_ac": "E1BJ78", "gene_name": "LOC783020", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ] } ] }, { "uniprot_ac": "F1MZX9", "gene_name": "SULT6B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ] } ] }, { "uniprot_ac": "P19217", "gene_name": "SULT1E1", "activity": [ { "ec_number": "2.8.2.4", "activity": "estrone + 3'-phosphoadenylyl sulfate = estrone 3-sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] }, { "ec_number": "2.8.2.4", "activity": "", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] } ] }, { "uniprot_ac": "P50227", "gene_name": "SULT1A1", "activity": [ { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] } ] }, { "uniprot_ac": "Q3T0Y3", "gene_name": "SULT1B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 298, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ78" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" }, { "id": "PF00685", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfotransferase", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJ82-1", "uniprot_ac": "E1BJ82", "uniprot_id": "E1BJ82_BOVIN", "mass": { "chemical_mass": 8186.0, "monoisotopic_mass": 8186.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "E1BJ82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ82/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJ82", "url": "https://www.uniprot.org/uniprotkb/E1BJ82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BJ82", "locus": {} } ], "crossref": [ { "id": "E1BJ82", "url": "https://alphafold.ebi.ac.uk/entry/E1BJ82", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032047", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032047", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ICVYKPL", "url": "https://omabrowser.org/oma/group/ICVYKPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ82", "url": "https://www.uniprot.org/uniprotkb/E1BJ82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ82-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSVWQWLCLGLCSLLLGQAEAPTPVEPPERSRPYAVLRGQNLVLMGTIFSLLLVTVILMAFCVYKPIRRR", "length": 72, "header": "tr|E1BJ82-1|E1BJ82_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=E1BJ82-1" }, "isoforms": [ { "isoform_ac": "E1BJ82-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ82/entry#E1BJ82-1", "sequence": { "sequence": "MLRSVWQWLCLGLCSLLLGQAEAPTPVEPPERSRPYAVLRGQNLVLMGTIFSLLLVTVILMAFCVYKPIRRR", "length": 72, "header": "tr|E1BJ82-1|E1BJ82_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=E1BJ82-1" }, "locus": { "chromosome": "17", "start_pos": 63261146, "end_pos": 63256653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045464.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045464.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042852.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042852.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U1J3-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC107051594", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLRGWALAVLAALTPAERSRPYAVLQKQNLVLLGSILSALLLTIVLMAVCVYKPVRRR", "length": 59 }, "evidence": [ { "id": "E1BJ82", "url": "https://omabrowser.org/oma/group/E1BJ82/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1T525-1", "protein_name": "Chromosome 12 open reading frame 76", "gene_name": "C12orf76", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRPVGWWLNLGLCSLLLGQAEAPSPVEPPERSRPYAVLRGQNLVLMGTIFSILLVTMILMAFCVYKPIRRR", "length": 72 }, "evidence": [ { "id": "E1BJ82", "url": "https://omabrowser.org/oma/group/E1BJ82/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3Z4G5-1", "protein_name": "Predicted gene, 57857", "gene_name": "Gm57857", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRLGWMRLLPVLCSLLLGRAEAPSPGLPPEQSRSYEVLRRQSLVLMGTIFSILLVTVLLMAFCVYKPIRRR", "length": 72 }, "evidence": [ { "id": "E1BJ82", "url": "https://omabrowser.org/oma/group/E1BJ82/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N812-1", "protein_name": "Uncharacterized protein C12orf76", "gene_name": "C12orf76", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFQNLQGTFEKEIGKIIPFTIAFKRAEAVEPDGCVQSWRCCLPCDLGQASRFIHTTVCSAIRWRSCKGERNFAERHILPAELEEQSNHAGMGPILPAMPSVDGNHFQHPAGDCHPYGILCLQAHSASVTARQVLQ", "length": 135 }, "evidence": [ { "id": "E1BJ82", "url": "https://omabrowser.org/oma/group/E1BJ82/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJ82-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 72, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJ82-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJ82" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJA6-1", "uniprot_ac": "E1BJA6", "uniprot_id": "E1BJA6_BOVIN", "mass": { "chemical_mass": 62924.0, "monoisotopic_mass": 62924.0 }, "refseq": { "ac": "NP_001192678", "name": "F-box only protein 33", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192678" }, "gene_names": [ { "name": "FBXO33", "type": "recommended", "evidence": [ { "id": "E1BJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA6" } ] }, { "name": "FBXO33", "type": "synonym", "evidence": [ { "id": "NP_001192678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192678" } ] } ], "protein_names": [ { "name": "F-box only protein 33", "type": "synonym", "evidence": [ { "id": "NP_001192678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192678" } ] }, { "name": "F-box protein 33", "type": "synonym", "evidence": [ { "id": "E1BJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJA6", "url": "https://www.uniprot.org/uniprotkb/E1BJA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO33", "url": "https://www.uniprot.org/uniprotkb/E1BJA6", "locus": { "chromosome": "21", "start_pos": 49289714, "end_pos": 49310143, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006836", "url": "https://www.ensembl.org/id/ENSBTAG00000006836" } ] } } ], "crossref": [ { "id": "E1BJA6", "url": "https://alphafold.ebi.ac.uk/entry/E1BJA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006836", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539998", "url": "https://www.ncbi.nlm.nih.gov/gene/539998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539998", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539998", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSRQMKW", "url": "https://omabrowser.org/oma/group/NSRQMKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJA6", "url": "https://www.orthodb.org/?gene=E1BJA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20933", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20933", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20933:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20933:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJA6", "url": "https://www.uniprot.org/uniprotkb/E1BJA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRGLRGRPGTGSRRRGRMALCGQAAGAASLPSELIVHIFSFLSASDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGGGGPGDGGGSADAGTGGEEVEALQLSTRWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNSIANTMEHLSLLDNNTPGSSTLITAAELERFVNLRSLALDFCDFTAEMARVLTDNNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSLRVYIMAFDMKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDV", "length": 560, "header": "tr|E1BJA6-1|E1BJA6_BOVIN Isoform 1 of F-box protein 33 OS=Bos taurus OX=9913 GN=FBXO33 PE=4 SV=1 CANONICAL=E1BJA6-1" }, "isoforms": [ { "isoform_ac": "E1BJA6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA6/entry#E1BJA6-1", "sequence": { "sequence": "MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRGLRGRPGTGSRRRGRMALCGQAAGAASLPSELIVHIFSFLSASDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGGGGPGDGGGSADAGTGGEEVEALQLSTRWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNSIANTMEHLSLLDNNTPGSSTLITAAELERFVNLRSLALDFCDFTAEMARVLTDNNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSLRVYIMAFDMKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDV", "length": 560, "header": "tr|E1BJA6-1|E1BJA6_BOVIN Isoform 1 of F-box protein 33 OS=Bos taurus OX=9913 GN=FBXO33 PE=4 SV=1 CANONICAL=E1BJA6-1" }, "locus": { "chromosome": "21", "start_pos": 49309988, "end_pos": 49289811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008982.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008982.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008982.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008982.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539998", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539998", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ADZ5-1", "protein_name": "F-box protein 33", "gene_name": "Fbxo33", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLFLSVPQPRPPGARTRAGAARVVRWRRRQRLRLRQLRRLRGLLRGLRGRSGTSGRRRSRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGPGDGGGSGGGTDTGNGGEESEALQLSSRWLEVLRIYLELVLCVLLSIRNNRNLQKFSLFGDISVVQQQGSLSSTYLSRVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPSSLSSLSNSIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNASVMLKSLDNMPNDEHWKALSRKSSSLRVYLMAFDVKSEDMLKILKPSIPLERVHFDSYVTCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLLEQVSLGLGQSWHAVLDIESLSVFTEPNRHFYREMQSFSEDI", "length": 563 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AC58HQS1-1", "protein_name": "F-box only protein 33 isoform X1", "gene_name": "fbxo33", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MIAQLFVFTQRSKQGGEEKRRGTELCNDRDKLRASAVCTRWRECLFYPALWTELKLRIGGGTNGGGSGSDQTPRLEFLMRKFGSFVRELQLEFAPVNNYLSPLQHGVDAVESDPQFAKDAMVTYLDQVLCVLGSLRNNRNLQKLSLYGDTCILHEDGILDSTYLSQVDQGGKKMKEIQQLFEEILSNSRQMKWLSCAFMLGVVTPCSLASLSNPSSSSLQHLSLIDNQLPSLISTLELERLAHLHSLSLDFCDFTSDMCRLLACGDRAPLHRLSLLLNGAALDVKPLDGTAAEDDWKALVRRSTNLRVYIMGMDVHSQDLLRVLKPSVPLERIHLDSYSTLVTDGVIELISQQYHKTLTHFILMRDDAGFPDLSVNRNEDPLVLLTWRCLHLAVLIIHGYTVWSHNLVAISRLRGSNLKVLEVSEESIDFDPDQSVYIEGDPVHNLVKEVSLGLGRVWHPSMDNSVVLNEPTQHFHREMQSFSAGM", "length": 486 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1NBR9-1", "protein_name": "F-box protein 33", "gene_name": "FBXO33", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLFLSQEPQARPGPPPPVAAAAAAGLGPAPGMSVCGEAVGAGSLPSELVVHIFSFLAGPDRLRASAACSHWRECLFYPALWPRLRLSLRVSPAERPRLEFLMRKCGWFVRELRVQFAADNYPSGGPAAGEGAAVAAGDGEAAPLCPRWLELLRTYLELVLCVLSSVRNNRNLQKLSLFGDISILQQHGSISNTYLGKVDPDGKKIKQIQQLFEEILGNSRQLKWLSCGFMLQIVTPTSLSSLSNPIANTMEHLSLLDNHIPGNTTLITAVELERFVNLRSLALDFCDFTAEMARVLADSNHVPLHRLSLLVHSVSIMHKSLDSMPEDENWKALTRNSTNLRVYIMAFDVKSDDMLRILKPSIPLERIHFDSYITCVSGAVVDLISRQYDKFLTHFILMNDVIDMSGFPDLSDNRNEDPLVLLAWRCTRLSLLAVHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGRPWHAVMDIELLSVFTEPTRHFYREMQSFSEGI", "length": 526 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SIP8-1", "protein_name": "F-box protein 33", "gene_name": "FBXO33", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLFLSVPQPRPPGAGTRAGAARVARWRRRRLRLQQLRRLRGLLRGLRRRPGTGSRRRGRMALCGQAAGAASLPSELIVHIFSFLSASDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGPGDGGSADTGTGGEEVEALQLSSRWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDNNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTNLRVYMMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLSHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI", "length": 558 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Z6M2-1", "protein_name": "F-box only protein 33", "gene_name": "FBXO33", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI", "length": 555 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VE08-1", "protein_name": "F-box only protein 33", "gene_name": "Fbxo33", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLFLSVPQPRPPGARTRAGAARLVRWRRRQRLRLLQLRRLRGLLRGLRRRPGTGGRRPSRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGPGDGGSGGGTDTGTGGEDGEALQLSSRWLEVLRIYLELVLCVLLSIRNNRNLQKFSLFGDISVVHQQGSLSSTYLSRVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNPIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNASVMLKSLDNMPNDEHWKALSRKSSSLRVYLMVFDIKSEDMLKILKPSIPLERVHFDSYVTCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLQVTEESIDFDQGELADQDVDPVQNLIEQVSLGLGQSWHAVLDIESLSVFTEPNRHFYREMQSFSEDI", "length": 562 }, "evidence": [ { "id": "E1BJA6", "url": "https://omabrowser.org/oma/group/E1BJA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "E1BJA6", "url": "https://www.uniprot.org/uniprotkb/E1BJA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 560, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJA6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA6" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 111, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 293, "end_pos": 295 }, { "start_pos": 348, "end_pos": 350 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJA7-1", "uniprot_ac": "E1BJA7", "uniprot_id": "E1BJA7_BOVIN", "mass": { "chemical_mass": 18103.0, "monoisotopic_mass": 18103.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "E1BJA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJA7", "url": "https://www.uniprot.org/uniprotkb/E1BJA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BJA7", "locus": {} } ], "crossref": [ { "id": "E1BJA7", "url": "https://alphafold.ebi.ac.uk/entry/E1BJA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027221", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027221", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019351", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019351", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CACELEL", "url": "https://omabrowser.org/oma/group/CACELEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22876:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22876:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJA7", "url": "https://www.uniprot.org/uniprotkb/E1BJA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSQKGNVTRSRPQRHQNTFSFKNDKFDKSVQTKKINAKLHDGVCQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACELEVCAKCGKREDVVIPFNKEPEKTENVENNLRSSHRRSCRKNEENDDDLDFDIDLDDTEEDN", "length": 154, "header": "tr|E1BJA7-1|E1BJA7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BJA7-1" }, "isoforms": [ { "isoform_ac": "E1BJA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA7/entry#E1BJA7-1", "sequence": { "sequence": "MSSQKGNVTRSRPQRHQNTFSFKNDKFDKSVQTKKINAKLHDGVCQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACELEVCAKCGKREDVVIPFNKEPEKTENVENNLRSSHRRSCRKNEENDDDLDFDIDLDDTEEDN", "length": 154, "header": "tr|E1BJA7-1|E1BJA7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BJA7-1" }, "locus": { "chromosome": "13", "start_pos": 53575265, "end_pos": 53574804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008981.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008981.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008981.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008981.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AU16-1", "protein_name": "Chromosome 1 C9orf85 homolog", "gene_name": "C1H9orf85", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSQKGNVARSRPQRHQNTFSFKNDKFDKSVQTKKINAKLHDGVCQHCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIICRPCASELEVCAKCGKKEDIVIPFNKEPEKTENIENSLRSNHRRRGQRNEERDDDLDFDIDLDDNDNQMD", "length": 155 }, "evidence": [ { "id": "E1BJA7", "url": "https://omabrowser.org/oma/group/E1BJA7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FU5-1", "protein_name": "Uncharacterized protein C9orf85 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSQKGNVTRSRPQKHQNTFTFKNDKFDKSVQTKKINAKLHDGVCQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACKLEVCAKCGKEEEIVIPFNKEPEPSENTESEGSNHRRSCKRKEDSDEDLDAESDSEGEDEDTQA", "length": 155 }, "evidence": [ { "id": "E1BJA7", "url": "https://omabrowser.org/oma/group/E1BJA7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96MD7-3", "protein_name": "Uncharacterized protein C9orf85", "gene_name": "C9orf85", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSQKGNVARSRPQKHQNTFSFKNDKFDKSVQTKKINAKLHDGVCQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACELEVCAKCGKKEDIVIPWSLPLLPRLECSGRILAHHNLRLPCSSDSPASASRVAGTTGAHHHAQLIFVFLVEMGFHYVGQAGLELLTS", "length": 179 }, "evidence": [ { "id": "E1BJA7", "url": "https://omabrowser.org/oma/group/E1BJA7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJA7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJA7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJA7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJE4-1", "uniprot_ac": "E1BJE4", "uniprot_id": "E1BJE4_BOVIN", "mass": { "chemical_mass": 77317.0, "monoisotopic_mass": 77317.0 }, "refseq": { "ac": "NP_001192506", "name": "ERI1 exoribonuclease 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192506" }, "gene_names": [ { "name": "ERI2", "type": "recommended", "evidence": [ { "id": "E1BJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ] }, { "name": "ERI2", "type": "synonym", "evidence": [ { "id": "NP_001192506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192506" } ] } ], "protein_names": [ { "name": "ERI1 exoribonuclease 2", "type": "recommended", "evidence": [ { "id": "E1BJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE4/entry#names_and_taxonomy" } ] }, { "name": "ERI1 exoribonuclease 2", "type": "synonym", "evidence": [ { "id": "NP_001192506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192506" } ] }, { "name": "Exonuclease domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "E1BJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE4/entry#names_and_taxonomy" } ] }, { "name": "exoribonuclease 2", "type": "synonym", "evidence": [ { "id": "NP_001192506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192506" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERI2", "url": "https://www.uniprot.org/uniprotkb/E1BJE4", "locus": { "chromosome": "25", "start_pos": 18540730, "end_pos": 18556531, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006448", "url": "https://www.ensembl.org/id/ENSBTAG00000006448" } ] } } ], "crossref": [ { "id": "E1BJE4", "url": "https://alphafold.ebi.ac.uk/entry/E1BJE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006448", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006448", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06133", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06133", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538719", "url": "https://www.ncbi.nlm.nih.gov/gene/538719", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538719", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538719", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RAFFCCP", "url": "https://omabrowser.org/oma/group/RAFFCCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJE4", "url": "https://www.orthodb.org/?gene=E1BJE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23044", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23044", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23044:SF61", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23044:SF61", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00929", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00929", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192506", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATKRLARQLGLIRRKSIPPANGNLGRSKSKQLFDYLIIIDFESTCWNDGKRHRSQEIIEFPAVLLNTSTGEIESEFHAYVQPQEHPILSEFCVELTGIKQAQVDEGVPLKICLSQFCKWIQKIQQQKKIIFATTVSDISTSEVKLCAFVTWSDWDLGVCLEYECKRKQLLKPVFLNSWIDLRVTYKIFYRRKPKGLSGALQEVGMQFLGREHFGLDDSRNTALLAWKMIRDGCLMKITRSLNKVSTKRIPNIFTRNLNMDQVEETSTCTNNTHDPSIYGGEPKNSIKPYKKIQMKSVGVNSPIKVQQDQLQQKDSIKAGLCNVRSCLSLSNATKSWTSLGQLQSSSRNTPMQKQINQHLAFNTNSKSLAVGSELVPVSTTISSFNNVSDIEVSSALDCLPMLADWEDVALLPASQPEQNISCIPLVSDSNVDTSLNSGERVMVLEESEMLSHENFGGTEETPQKSVTSKSIVYKSPHTTIYNVKEAKDPGSDTFGFKLPERKSSNFNSVNSNVSHPLVLGKHRLCLDDSKRNPSSPPLFPPAKKQTFTIHEEKPASSNDSPGAISSWKILPSVLTSTVNLQEPWKSRKITPPLCKCGRRSKRLTVSNNGPNHGKVFYCCPVGKYQEKRKCCGYFKWEQTLQEERANSIVLSDSPGGLTFSSLETNLICDRNVNFSTKNSLRLRPSMRN", "length": 689, "header": "tr|E1BJE4-1|E1BJE4_BOVIN Isoform 1 of ERI1 exoribonuclease 2 OS=Bos taurus OX=9913 GN=ERI2 PE=3 SV=2 CANONICAL=E1BJE4-1" }, "isoforms": [ { "isoform_ac": "E1BJE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJE4/entry#E1BJE4-1", "sequence": { "sequence": "MATKRLARQLGLIRRKSIPPANGNLGRSKSKQLFDYLIIIDFESTCWNDGKRHRSQEIIEFPAVLLNTSTGEIESEFHAYVQPQEHPILSEFCVELTGIKQAQVDEGVPLKICLSQFCKWIQKIQQQKKIIFATTVSDISTSEVKLCAFVTWSDWDLGVCLEYECKRKQLLKPVFLNSWIDLRVTYKIFYRRKPKGLSGALQEVGMQFLGREHFGLDDSRNTALLAWKMIRDGCLMKITRSLNKVSTKRIPNIFTRNLNMDQVEETSTCTNNTHDPSIYGGEPKNSIKPYKKIQMKSVGVNSPIKVQQDQLQQKDSIKAGLCNVRSCLSLSNATKSWTSLGQLQSSSRNTPMQKQINQHLAFNTNSKSLAVGSELVPVSTTISSFNNVSDIEVSSALDCLPMLADWEDVALLPASQPEQNISCIPLVSDSNVDTSLNSGERVMVLEESEMLSHENFGGTEETPQKSVTSKSIVYKSPHTTIYNVKEAKDPGSDTFGFKLPERKSSNFNSVNSNVSHPLVLGKHRLCLDDSKRNPSSPPLFPPAKKQTFTIHEEKPASSNDSPGAISSWKILPSVLTSTVNLQEPWKSRKITPPLCKCGRRSKRLTVSNNGPNHGKVFYCCPVGKYQEKRKCCGYFKWEQTLQEERANSIVLSDSPGGLTFSSLETNLICDRNVNFSTKNSLRLRPSMRN", "length": 689, "header": "tr|E1BJE4-1|E1BJE4_BOVIN Isoform 1 of ERI1 exoribonuclease 2 OS=Bos taurus OX=9913 GN=ERI2 PE=3 SV=2 CANONICAL=E1BJE4-1" }, "locus": { "chromosome": "25", "start_pos": 18556228, "end_pos": 18541029, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008456.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008456.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008456.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008456.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538719", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538719", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I9S4-1", "protein_name": "ERI1 exoribonuclease 2", "gene_name": "Eri2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATKRLARRLGLIRRKSVAPASGNPGGSRFRQVYDYLIVIDFESTCWKDGKHHNSPEIIEFPAVLLSTATGEIESEFHAYVQPQEHPVLSEFCTELTGIKQVQVDEGVPLKICLSQFCKWIHKIQQQKKIILATGDLEPSTEVKLCAFVTWSDWDLGVCLEYECRRKQLLKPVFLNSWIDLRATYKLFYKRKPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCLMKITRSLNKVLTKKNPKILVKNLSTDQVKETSACNISIQGPSIYQKEPKSTVNTEENAQMNLISVNSSIKGQLQLKTNTKADRHNIKHCFPLFTAKPSTSMEQLSSPTVNPPLSMQKQRKSEQFALNDKSKSSALNSNLVLVSTTIPSVNVVPDGGVGCSFDCLPMLAEWEDVVLLPASQAEKDKDSVPSISDTNVDTSFNSGERVMASKEPEIISYENFEDLKETPQNFETSKSIVYKSPHSTIYNVKGAKHPGSDASAFKLPECKPFTSNSLNANASPNPSVLRKQPLLLGGTKRYSCSPPAFPPAKKQTFTVHEEKSTSSTCSPGTSSLKVLPSILTSTVNLQAPWESGKMTPPLCKCGRRSKRLTVSNNGPNHGKAFYCCPVGKHQEDRKCCGYFKWEQTLQKERANSKALSRSSEGLTFSSPETSHIHDRKSSFPIKNSLRLRPSMRN", "length": 687 }, "evidence": [ { "id": "E1BJE4", "url": "https://omabrowser.org/oma/group/E1BJE4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "pmid": "" }, { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000467", "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "pmid": "" }, { "name": "negative regulation of regulatory ncRNA-mediated heterochromatin formation", "id": "GO:0060906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060906", "evidence": [ { "database": "UniProtKB", "id": "E1BJE4", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 689, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJE4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE4" }, { "id": "PS51999", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51999" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GRF-type", "eco_id": "ECO_0000259", "start_pos": 595, "end_pos": 641, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 271, "end_pos": 273 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 559, "end_pos": 561 }, { "start_pos": 674, "end_pos": 676 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJF5-1", "uniprot_ac": "E1BJF5", "uniprot_id": "E1BJF5_BOVIN", "mass": { "chemical_mass": 41042.0, "monoisotopic_mass": 41042.0 }, "refseq": { "ac": "XP_015316210", "name": "actin-like protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316210" }, "gene_names": [ { "name": "ACTL8", "type": "recommended", "evidence": [ { "id": "E1BJF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ] }, { "name": "ACTL8", "type": "synonym", "evidence": [ { "id": "XP_015316210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316210" } ] } ], "protein_names": [ { "name": "Actin like 8", "type": "synonym", "evidence": [ { "id": "E1BJF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJF5/entry#names_and_taxonomy" } ] }, { "name": "actin-like protein 8", "type": "synonym", "evidence": [ { "id": "XP_015316210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316210" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTL8", "url": "https://www.uniprot.org/uniprotkb/E1BJF5", "locus": { "chromosome": "2", "start_pos": 134842681, "end_pos": 134929540, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006438", "url": "https://www.ensembl.org/id/ENSBTAG00000006438" } ] } } ], "crossref": [ { "id": "E1BJF5", "url": "https://alphafold.ebi.ac.uk/entry/E1BJF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006438", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006438", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528048", "url": "https://www.ncbi.nlm.nih.gov/gene/528048", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528048", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528048", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GRVLNWE", "url": "https://omabrowser.org/oma/group/GRVLNWE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJF5", "url": "https://www.orthodb.org/?gene=E1BJF5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015316210", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316210", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSARTIIIDHGSAFLKAGLSGWNEPQLVLPSVVNYIPCRENPGPSYARRRVSLGIDICRPDTFSYPVQRGRVINWEGVEHIWSFILEKHRLEHEDFPVIITESPLKEPVDRQKTLEILFELLNVPSVLLADQLEMSLYSSGLLTGVVVDSGCGLTRVQPFHLGRPLRPGATTLEFAGQDLSVYLFKSLFKEDYNRHNLFQLDTVASTQMRKCYVPQNLGDELDFYQNLPDGADERNSYHLPDGTAVELTPMQRLAPEMFFSPQVFGLQGPSLAQAAMDSIEACEASLRPLLASHVAPCGGNTLYPGFTMRLYQLLASHFFPTKASVFAGSNRHFSVWLGASVVAHLSTYKSEWLTKEEYDERFRL", "length": 365, "header": "tr|E1BJF5-1|E1BJF5_BOVIN Isoform 1 of Actin like 8 OS=Bos taurus OX=9913 GN=ACTL8 PE=3 SV=1 CANONICAL=E1BJF5-1" }, "isoforms": [ { "isoform_ac": "E1BJF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJF5/entry#E1BJF5-1", "sequence": { "sequence": "MSARTIIIDHGSAFLKAGLSGWNEPQLVLPSVVNYIPCRENPGPSYARRRVSLGIDICRPDTFSYPVQRGRVINWEGVEHIWSFILEKHRLEHEDFPVIITESPLKEPVDRQKTLEILFELLNVPSVLLADQLEMSLYSSGLLTGVVVDSGCGLTRVQPFHLGRPLRPGATTLEFAGQDLSVYLFKSLFKEDYNRHNLFQLDTVASTQMRKCYVPQNLGDELDFYQNLPDGADERNSYHLPDGTAVELTPMQRLAPEMFFSPQVFGLQGPSLAQAAMDSIEACEASLRPLLASHVAPCGGNTLYPGFTMRLYQLLASHFFPTKASVFAGSNRHFSVWLGASVVAHLSTYKSEWLTKEEYDERFRL", "length": 365, "header": "tr|E1BJF5-1|E1BJF5_BOVIN Isoform 1 of Actin like 8 OS=Bos taurus OX=9913 GN=ACTL8 PE=3 SV=1 CANONICAL=E1BJF5-1" }, "locus": { "chromosome": "2", "start_pos": 134846603, "end_pos": 134843163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008439.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008439.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008439.2", "url": "https://www.ensembl.org/id/ENSBTAP00000008439.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528048", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528048", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9H568-1", "protein_name": "Actin-like protein 8", "gene_name": "ACTL8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARTVIIDHGSGFLKAGTAGWNEPQMVFPNIVNYLPCKENPGPSYARRRVSLGIDICHPDTFSYPIERGRILNWEGVQYLWSFVLENHRREQEVPPVIITETPLREPADRKKMLEILFELLHVPSVLLADQLQMSLYASGLLTGVVVDSGYGLTRVQPFHQGRPLPASGKTLEFAGQDLSAYLLKSLFKEDCDRRCLFQLETVAVTQMNKCYVPQNLGEALDFRERQQSALDESNTYQLPDGSRVELTPMQRVAPEMFFSPQVFEQPGPSIPRAIVESVESCEISLRPLLVSHVMACGGNTLYPGFTKRLFRELMGDHVSSTKATVWEGSNRNFSVWLGASVVAHLSTYQSEWMSREEYGEHMRM", "length": 366 }, "evidence": [ { "id": "E1BJF5", "url": "https://omabrowser.org/oma/group/E1BJF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "cell motility", "id": "GO:0048870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048870", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" }, { "name": "structural constituent of postsynaptic actin cytoskeleton", "id": "GO:0098973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098973", "evidence": [ { "database": "UniProtKB", "id": "E1BJF5", "url": "https://www.uniprot.org/uniprotkb/E1BJF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJF5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 365, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJF5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJF5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJG7-1", "uniprot_ac": "E1BJG7", "uniprot_id": "E1BJG7_BOVIN", "mass": { "chemical_mass": 36540.0, "monoisotopic_mass": 36540.0 }, "refseq": { "ac": "XP_002693197", "name": "uncharacterized protein C11orf42 homolog isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693197" }, "gene_names": [ { "name": "C15H11orf42", "type": "recommended", "evidence": [ { "id": "E1BJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJG7" } ] }, { "name": "C15H11orf42", "type": "synonym", "evidence": [ { "id": "XP_002693197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693197" } ] } ], "protein_names": [ { "name": "Chromosome 15 C11orf42 homolog", "type": "synonym", "evidence": [ { "id": "E1BJG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJG7/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C11orf42 homolog isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002693197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693197" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJG7", "url": "https://www.uniprot.org/uniprotkb/E1BJG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C15H11orf42", "url": "https://www.uniprot.org/uniprotkb/E1BJG7", "locus": { "chromosome": "15", "start_pos": 46828022, "end_pos": 46832117, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027642", "url": "https://www.ensembl.org/id/ENSBTAG00000027642" } ] } } ], "crossref": [ { "id": "E1BJG7", "url": "https://alphafold.ebi.ac.uk/entry/E1BJG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027642", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027642", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617978", "url": "https://www.ncbi.nlm.nih.gov/gene/617978", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617978", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617978", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTQEYSP", "url": "https://omabrowser.org/oma/group/CTQEYSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJG7", "url": "https://www.orthodb.org/?gene=E1BJG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36872", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36872", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36872:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36872:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15668", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15668", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693197", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693197", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJG7", "url": "https://www.uniprot.org/uniprotkb/E1BJG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJG7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLVGTPHLLTLDEADATWTLIKDKVIEERFGPNVVAVPFLSDAACYDLLGVLVKQSRPAHSRLALPGRQGRRALQPVGLLPNLLEQAGSEGAFAHCTREYSPNSRAEITYEEMRLLDGQPCRIHLHMGGLRKKMAFLLLPPGQVSLQPSLPWLRSTHSIYIIYQVFSCSWLQLGLLPTAHEPQLLRLQRSLPIAFSCLKFSLQPKGVLGPQKPLIKDPLPQGASWARPNLSIMPPPAPTSASDDIPEAADVPQPVPAPPTPPPQEGPECRPTRFSYKGRNPFRRGPQMLSENWLFSPRNPPPGAQGGGPGDPDRHSMSLPLLQGLSSEFDSDE", "length": 333, "header": "tr|E1BJG7-1|E1BJG7_BOVIN Isoform 1 of Chromosome 15 C11orf42 homolog OS=Bos taurus OX=9913 GN=C15H11orf42 PE=4 SV=1 CANONICAL=E1BJG7-1" }, "isoforms": [ { "isoform_ac": "E1BJG7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJG7/entry#E1BJG7-1", "sequence": { "sequence": "MLVGTPHLLTLDEADATWTLIKDKVIEERFGPNVVAVPFLSDAACYDLLGVLVKQSRPAHSRLALPGRQGRRALQPVGLLPNLLEQAGSEGAFAHCTREYSPNSRAEITYEEMRLLDGQPCRIHLHMGGLRKKMAFLLLPPGQVSLQPSLPWLRSTHSIYIIYQVFSCSWLQLGLLPTAHEPQLLRLQRSLPIAFSCLKFSLQPKGVLGPQKPLIKDPLPQGASWARPNLSIMPPPAPTSASDDIPEAADVPQPVPAPPTPPPQEGPECRPTRFSYKGRNPFRRGPQMLSENWLFSPRNPPPGAQGGGPGDPDRHSMSLPLLQGLSSEFDSDE", "length": 333, "header": "tr|E1BJG7-1|E1BJG7_BOVIN Isoform 1 of Chromosome 15 C11orf42 homolog OS=Bos taurus OX=9913 GN=C15H11orf42 PE=4 SV=1 CANONICAL=E1BJG7-1" }, "locus": { "chromosome": "15", "start_pos": 46832117, "end_pos": 46828025, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039810.2", "url": "https://www.ensembl.org/id/ENSBTAT00000039810.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000039598.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 260, "start_aa": "Thr", "end_pos": 260, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr260", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617978", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617978", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3YVJ1-1", "protein_name": "Predicted gene 5901", "gene_name": "Gm5901", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLVSSPHLLTLDEADATWALIKDKVIEERFGSNVVAVPFLSDAAYYDLLGVLVKQSRPAHTRLALPGRQGRRALKSVGLLPNLLEQAGSEGIFAHCTREYSPNGRAETAYEEMRMMDGQPCRIRLHMGGLRKKVAFLLLPPGQVSLQQNLPWLRSTHSIYVIYQVFSCTWLQLGLLPTAREPQLIRLQRSLPIAFSCLKFSLQPKGVLGPQKSLTKDPLPQGANWVRPSLSIISTLAPTSVSADTHEVADVPPPVPAPPTPPPQEGPEGRPTRFSHKGRNPFRRGPYMLSENWLFSPRNPPPGAQGGGPGDPDRHSMSLPLLQGLSSEFDSDE", "length": 333 }, "evidence": [ { "id": "E1BJG7", "url": "https://omabrowser.org/oma/group/E1BJG7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1RML9-1", "protein_name": "Chromosome 9 C11orf42 homolog", "gene_name": "C9H11orf42", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLAGTPNLLTLDEADATWTLIKDKVTEERFGPNVVAVPFLSDAACYDLLGVLVKQSRPAHTRLALPGRQGRRALQPVGPLPNLLEQAGSEGAFAHCTREYSPNGRAEIAYEEMRLLDGQPCRICLHMGGLRKKVAFLLLPPGQVGLRQTLPWLRSAHSIYVIYQVFSCSWLQLGLLPTAQEPQLLRLQRSLPIAFSCLKFSLQPKGVLGPQKPLTKDPLPHGASWVRPNLSILPPPAPASAPDDTPEAAGVSPPIPAPPTPPPQEGPEGRPTRLSHKGRNPFRRGPQMLSENWLFSPRNPPPGAQGGGPGDPDRHSMSLPLLQGLSSEFDSDE", "length": 333 }, "evidence": [ { "id": "E1BJG7", "url": "https://omabrowser.org/oma/group/E1BJG7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N5U0-1", "protein_name": "Uncharacterized protein C11orf42", "gene_name": "C11orf42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLVGTPNLLTLDEADATWTLIKDKVIEEHFGPNAVAVPFLSDAACYDLLGVLVKQSRPAHTRLALPGRQGRRALKPVGPLPSLLEQAGSEGAFAHCTREYSPNGRAERAYEETRMLDGQPCKIRLHMGDLRKKVAFLLLPPGQVSLQQTLPWLRSTHSIYVIYQVFSCSWLQLGLTSTAREPQLLRLLRSLPVAFSCLKFSLQSKGVLGPQKPLTKDPLPHGANWVRPNLSIMPPLAPTSAPADTTEAADVPPPVPAPPTPPPQEGPEDKPTRFSYKGRNPFWRGPQILSENWLFSPRSPPPGAQGGGPRDPDGHSMSLPLLQGLSSEFDSDD", "length": 333 }, "evidence": [ { "id": "E1BJG7", "url": "https://omabrowser.org/oma/group/E1BJG7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "E1BJG7", "url": "https://www.uniprot.org/uniprotkb/E1BJG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 333, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJG7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 239, 260 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJG8-1", "uniprot_ac": "E1BJG8", "uniprot_id": "E1BJG8_BOVIN", "mass": { "chemical_mass": 38620.0, "monoisotopic_mass": 38620.0 }, "refseq": { "ac": "XP_002697819", "name": "coiled-coil domain-containing protein 68 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697819" }, "gene_names": [ { "name": "CCDC68", "type": "recommended", "evidence": [ { "id": "E1BJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ] }, { "name": "CCDC68", "type": "synonym", "evidence": [ { "id": "XP_002697819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697819" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 68", "type": "synonym", "evidence": [ { "id": "E1BJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJG8/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 68 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697819" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC68", "url": "https://www.uniprot.org/uniprotkb/E1BJG8", "locus": { "chromosome": "24", "start_pos": 54267234, "end_pos": 54325904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008158", "url": "https://www.ensembl.org/id/ENSBTAG00000008158" } ] } } ], "crossref": [ { "id": "E1BJG8", "url": "https://alphafold.ebi.ac.uk/entry/E1BJG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504721", "url": "https://www.ncbi.nlm.nih.gov/gene/504721", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504721", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504721", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETEYIKQ", "url": "https://omabrowser.org/oma/group/ETEYIKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJG8", "url": "https://www.orthodb.org/?gene=E1BJG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23171:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23171:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002697819", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697819", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJG8-1", "url": "https://www.uniprot.org/uniprotkb/E1BJG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTVTGTATVPQGGKTEDDSAMYESPSAHIIEETEYVRKIRTTLEKIRNQIFRDEVRHNSANHKLDAKRCGNIQNGSDSAADFSGGSLDPLMERIKGKDLQLSEMNKENEVLKIKLEASREAGAVALRNVAQRLLENYQTRSEEVRKKHEDRRHLLQVDKLEKEQKLKQHVENLDQIAEKLEEKHKQITELENLVQRMEKEKRTLLEKKLSLENKLLHLKSNATNAKSCQDLQKEISLLQEQISHLQFVIHSQHQNLRSVIQEMEALKNNLKEQDKRIEDLQEKVNILEAQNKELKAKVALWPETPGTKVSKAVSTSELKTEDTTPYLMLVRLRK", "length": 335, "header": "tr|E1BJG8-1|E1BJG8_BOVIN Isoform 1 of Coiled-coil domain containing 68 OS=Bos taurus OX=9913 GN=CCDC68 PE=4 SV=3 CANONICAL=E1BJG8-1" }, "isoforms": [ { "isoform_ac": "E1BJG8-1", "url": "https://www.uniprot.org/uniprotkb/E1BJG8/entry#E1BJG8-1", "sequence": { "sequence": "MTTVTGTATVPQGGKTEDDSAMYESPSAHIIEETEYVRKIRTTLEKIRNQIFRDEVRHNSANHKLDAKRCGNIQNGSDSAADFSGGSLDPLMERIKGKDLQLSEMNKENEVLKIKLEASREAGAVALRNVAQRLLENYQTRSEEVRKKHEDRRHLLQVDKLEKEQKLKQHVENLDQIAEKLEEKHKQITELENLVQRMEKEKRTLLEKKLSLENKLLHLKSNATNAKSCQDLQKEISLLQEQISHLQFVIHSQHQNLRSVIQEMEALKNNLKEQDKRIEDLQEKVNILEAQNKELKAKVALWPETPGTKVSKAVSTSELKTEDTTPYLMLVRLRK", "length": 335, "header": "tr|E1BJG8-1|E1BJG8_BOVIN Isoform 1 of Coiled-coil domain containing 68 OS=Bos taurus OX=9913 GN=CCDC68 PE=4 SV=3 CANONICAL=E1BJG8-1" }, "locus": { "chromosome": "24", "start_pos": 54306044, "end_pos": 54267960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010727.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010727.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010727.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010727.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504721", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504721", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MCP3-1", "protein_name": "Coiled-coil domain-containing protein 68", "gene_name": "Ccdc68", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTVTVTTEVSPRGKTEGDSVLYGSSSAHIIEETEYVKKIRTTLEKVRNHMFKDEEEHGNENYLLDAEQSGNFQNGSDLTTDPNSLDFLMENMRRKDQQLLEMNRENEMLKIKLEASREAGAAALRNVAQRLFDNYQTHSEDMKKKQEDGRRLLQINSLEKEQTLKQRAENLSQLSEKLEEKHGQIIGLENRVQRMENEKKTLLERKLCLESKLLQLKSHDVHSKSCQDLQTEISILQEQICHLQFVIHSQHQSLHSLIEEMEGLKNTLKEQDKNIENLKEKVNILEAQNKDLKTKVAHWSETPKTSVSKAVSTSELKTEGASPYLMLIRLRK", "length": 333 }, "evidence": [ { "id": "E1BJG8", "url": "https://omabrowser.org/oma/group/E1BJG8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I5Y0E9-1", "protein_name": "Coiled-coil domain containing 68", "gene_name": "Ccdc68", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTVTVTMEVPSGGKTEDRSIFSGPSSAQIIEETEYVRKIRTTLEKIRNRMFKEEDGRGNARHKVDAEQSGNVQNGLDSTTDPTRLDLLLESMRRKDQQLLEMNKENEVLQIKLEASREAGAAALRNAAQRLFDNYQTQSEDLEKKHKDSKHVLQVNKLEKEQTLKQRAKNLSQLSEKLGEKHEQIVGLENRVQRMENEKKALLERKLCLESKLLQLKSNAANSKSCQHLQTEISILQEQICHLQFVIHSQHQNLRNIIQEMEGLKNTLKEQDKKIENLKEKVTVLEAQNEELKTKVAHWTESPRTSVSKAVSTSELKTEGASPYLMLIRLRK", "length": 333 }, "evidence": [ { "id": "E1BJG8", "url": "https://omabrowser.org/oma/group/E1BJG8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S1Z2-1", "protein_name": "Coiled-coil domain containing 68", "gene_name": "CCDC68", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTVPLRGKIEDHSASFESTSAHIIEETEYVKKIRTTLEKIRNQIFKDEVRHNSTNHRLDAKHYGNIQNASDSEMDPSCSLDLLMERIKGKDRQLLEMNKENEVLKIKLEASREAGAAALRNVAQRLFENYQTQSEEARKKHEDNRHLLQVNKLEKEQKLNHHVENLNQIAEKLEEKHNQITELENLVQRMEKEKRTLLDKKLSLENKLLHLKSTTTYPKSCQDLQKEISLLQEQIAHLQFVIHSQHQNLRSVIQEMEDLKNNLKEQDKRIENLKEKVNILEAQNKELKTKVALCSETPRTKVSKAVSTSELKTEGTTPYLMLVRLRK", "length": 328 }, "evidence": [ { "id": "E1BJG8", "url": "https://omabrowser.org/oma/group/E1BJG8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BVC4-1", "protein_name": "Coiled-coil domain-containing protein 68", "gene_name": "Ccdc68", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTVTVTTEVPSSGKTEDGHVFCDSSSAHIIEETEYVRQMRTTLEKIRNHMFKEKEGCGNARHKLDAEGSGNIQNGSDSTTDPTCLDLLMENMRRKDQQLLEMNRENEVLQIKLEASREAGAAALRNVAQRLFDNYQTQAGDLEKKHEGRKHLLQVNNLEKEQALKGSAESLNLLSEKLEEKHGQIVGLENRVQRMENEKKTLLEKKLRLESKLFQLKSNAANPKSCQDLQTEISILQEQISHLQFVIHSQHQNLRSIIQEMEGLKNTLKEQDTKIENLKEKVTVLEAQNKELKTRVAHWTETPRTLVSKAVSTSELKTEGASPYLMLIRLRK", "length": 333 }, "evidence": [ { "id": "E1BJG8", "url": "https://omabrowser.org/oma/group/E1BJG8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2F9-1", "protein_name": "Coiled-coil domain-containing protein 68", "gene_name": "CCDC68", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK", "length": 335 }, "evidence": [ { "id": "E1BJG8", "url": "https://omabrowser.org/oma/group/E1BJG8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ], "pmid": "" }, { "name": "centriolar subdistal appendage", "id": "GO:0120103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "database": "UniProtKB", "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ], "pmid": "" }, { "name": "microtubule anchoring at centrosome", "id": "GO:0034454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034454", "evidence": [ { "database": "UniProtKB", "id": "E1BJG8", "url": "https://www.uniprot.org/uniprotkb/E1BJG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJG8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJG8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJG8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJI2-1", "uniprot_ac": "E1BJI2", "uniprot_id": "E1BJI2_BOVIN", "mass": { "chemical_mass": 34955.0, "monoisotopic_mass": 34955.0 }, "refseq": {}, "gene_names": [ { "name": "KATNBL1", "type": "recommended", "evidence": [ { "id": "E1BJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" } ] } ], "protein_names": [ { "name": "Katanin regulatory subunit B1 like 1", "type": "synonym", "evidence": [ { "id": "E1BJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJI2", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KATNBL1", "url": "https://www.uniprot.org/uniprotkb/E1BJI2", "locus": { "chromosome": "10", "start_pos": 28460537, "end_pos": 28440551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006413", "url": "https://www.ensembl.org/id/ENSBTAG00000006413" } ] } } ], "crossref": [ { "id": "E1BJI2", "url": "https://alphafold.ebi.ac.uk/entry/E1BJI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJI2", "url": "https://www.orthodb.org/?gene=E1BJI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14682:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14682:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13925", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13925", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TFN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJI2", "url": "https://www.uniprot.org/uniprotkb/E1BJI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJI2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPDKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRHDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKKNIWKKVKNPG", "length": 305, "header": "tr|E1BJI2-1|E1BJI2_BOVIN Isoform 1 of Katanin regulatory subunit B1 like 1 OS=Bos taurus OX=9913 GN=KATNBL1 PE=4 SV=3 CANONICAL=E1BJI2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI2/entry#A0AAA9TFN3-1", "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPDKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRHDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGCRCLFITVALKDFIYSIWLFKTSLDDMISPEISHLRTVNYGRNQNHFFL", "length": 339, "header": "tr|A0AAA9TFN3-1|A0AAA9TFN3_BOVIN Computationally mapped isoform of Katanin regulatory subunit B1 like 1 OS=Bos taurus OX=9913 GN=KATNBL1 PE=4 SV=1 CANONICAL=E1BJI2-1" }, "locus": { "chromosome": "10", "start_pos": 28451432, "end_pos": 28440565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093492.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093492.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095814.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095814.1" } ] } }, { "isoform_ac": "A0AAA9TW21-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI2/entry#A0AAA9TW21-1", "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPDKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRHDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKVRLVKAMVFPVVMYGCESWTVKKAERRRIDAFELWCWRIL", "length": 334, "header": "tr|A0AAA9TW21-1|A0AAA9TW21_BOVIN Computationally mapped isoform of Katanin regulatory subunit B1 like 1 OS=Bos taurus OX=9913 GN=KATNBL1 PE=4 SV=1 CANONICAL=E1BJI2-1" }, "locus": { "chromosome": "10", "start_pos": 28459533, "end_pos": 28440565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100808.1" } ] } }, { "isoform_ac": "E1BJI2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI2/entry#E1BJI2-1", "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPDKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRHDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKKNIWKKVKNPG", "length": 305, "header": "tr|E1BJI2-1|E1BJI2_BOVIN Isoform 1 of Katanin regulatory subunit B1 like 1 OS=Bos taurus OX=9913 GN=KATNBL1 PE=4 SV=3 CANONICAL=E1BJI2-1" }, "locus": { "chromosome": "10", "start_pos": 28450149, "end_pos": 28440565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008409.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008409.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008409.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008409.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BJI2", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BJI2", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BJI2", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 305, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJI2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJI2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI2" }, { "id": "PF13925", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13925" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Katanin p80 subunit C-terminal", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 295, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJI3-1", "uniprot_ac": "E1BJI3", "uniprot_id": "E1BJI3_BOVIN", "mass": { "chemical_mass": 13438.0, "monoisotopic_mass": 13438.0 }, "refseq": { "ac": "XP_002684880", "name": "urotensin-2B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684880" }, "gene_names": [ { "name": "UTS2B", "type": "recommended", "evidence": [ { "id": "E1BJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ] }, { "name": "UTS2B", "type": "synonym", "evidence": [ { "id": "XP_002684880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684880" } ] } ], "protein_names": [ { "name": "Urotensin 2B", "type": "synonym", "evidence": [ { "id": "E1BJI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI3/entry#names_and_taxonomy" } ] }, { "name": "urotensin-2B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002684880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684880" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UTS2B", "url": "https://www.uniprot.org/uniprotkb/E1BJI3", "locus": { "chromosome": "1", "start_pos": 76062788, "end_pos": 76047771, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044148", "url": "https://www.ensembl.org/id/ENSBTAG00000044148" } ] } } ], "crossref": [ { "id": "E1BJI3", "url": "https://alphafold.ebi.ac.uk/entry/E1BJI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044148", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614653", "url": "https://www.ncbi.nlm.nih.gov/gene/614653", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614653", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614653", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR36876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36876:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36876:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28458", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28458", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002684880", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684880", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJI3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNVILSTTLSFGLLTLLSVMIFLESVHGVPYFVQGNELLPDKEDADGEELLLALLNKNFGFQRPSNIDIELADKLEELNQLEKLKEQLMEAKDAEMSYAIDGLSSSHPNKRACFWKYCV", "length": 119, "header": "tr|E1BJI3-1|E1BJI3_BOVIN Isoform 1 of Urotensin 2B OS=Bos taurus OX=9913 GN=UTS2B PE=3 SV=4 CANONICAL=E1BJI3-1" }, "isoforms": [ { "isoform_ac": "E1BJI3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI3/entry#E1BJI3-1", "sequence": { "sequence": "MNVILSTTLSFGLLTLLSVMIFLESVHGVPYFVQGNELLPDKEDADGEELLLALLNKNFGFQRPSNIDIELADKLEELNQLEKLKEQLMEAKDAEMSYAIDGLSSSHPNKRACFWKYCV", "length": 119, "header": "tr|E1BJI3-1|E1BJI3_BOVIN Isoform 1 of Urotensin 2B OS=Bos taurus OX=9913 GN=UTS2B PE=3 SV=4 CANONICAL=E1BJI3-1" }, "locus": { "chromosome": "1", "start_pos": 76062785, "end_pos": 76047771, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061012.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061012.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053859.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053859.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614653", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614653", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of blood pressure", "id": "GO:0008217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008217", "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "pmid": "" }, { "name": "blood vessel diameter maintenance", "id": "GO:0097746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097746", "evidence": [ { "database": "UniProtKB", "id": "E1BJI3", "url": "https://www.uniprot.org/uniprotkb/E1BJI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 119, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJI6-1", "uniprot_ac": "E1BJI6", "uniprot_id": "E1BJI6_BOVIN", "mass": { "chemical_mass": 94462.0, "monoisotopic_mass": 94462.0 }, "refseq": { "ac": "XP_005205433", "name": "F-box and leucine-rich repeat protein 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205433" }, "gene_names": [ { "name": "FBXL13", "type": "recommended", "evidence": [ { "id": "E1BJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" } ] }, { "name": "FBXL13", "type": "synonym", "evidence": [ { "id": "XP_005205433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205433" } ] } ], "protein_names": [ { "name": "F-box and leucine-rich repeat protein 13", "type": "recommended", "evidence": [ { "id": "E1BJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI6/entry#names_and_taxonomy" } ] }, { "name": "Dynein regulatory complex subunit 6", "type": "synonym", "evidence": [ { "id": "E1BJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI6/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 13", "type": "synonym", "evidence": [ { "id": "XP_005205433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205433" } ] }, { "name": "F-box/LRR-repeat protein 13", "type": "synonym", "evidence": [ { "id": "E1BJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity.", "evidence": [ { "database": "UniProtKB", "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6#function" }, { "database": "UniProtKB", "id": "ARBA00058421", "url": "https://www.uniprot.org/uniprotkb/ARBA00058421#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL13", "url": "https://www.uniprot.org/uniprotkb/E1BJI6", "locus": { "chromosome": "4", "start_pos": 44146674, "end_pos": 44363627, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016324", "url": "https://www.ensembl.org/id/ENSBTAG00000016324" } ] } } ], "crossref": [ { "id": "E1BJI6", "url": "https://alphafold.ebi.ac.uk/entry/E1BJI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016324", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016324", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22124", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22124", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22977", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22977", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101905084", "url": "https://www.ncbi.nlm.nih.gov/gene/101905084", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905084", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905084", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCW5", "url": "https://www.orthodb.org/?gene=A0A3Q1MCW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BJI6", "url": "https://www.orthodb.org/?gene=E1BJI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF95", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF95", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005205433", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205433", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCW5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCW5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJI6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLRRASPRLRKYFRENYIPQVCEALLCGLLVTCPEDPLRYLEEMIIGIMENGLETLLWDMCIDPLMKPKIRRLSETYLEQLFGLDDQLMTPELMIRACTFYTGRLLKTHFHTWREIAIPPTNEDELLAEKMEAAIVYANFRLKKHVLHHWHSYVKNRKEQLRDALLRIQKMFHCYKMIVTLNKWRDRARHKFKKREDELMLKHELQLQKFSKLKFKTSSKEEYFFPEQFVSEGFPVGGIPEFDISQLPKRAILQIFSYLSLRDLVICGQVNRSWLLMTQMGSLWNGIDFSAVKNIITDKYIVSILQRWRLNVLRLNFRGCALRLKTLRSVSFCKNLQELNVSDCPTLTDESMRYISESCPGVLYLNLSNTIITNRTMRLLPRYFYNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIANSCSGIMHLTINDMPTLTDNCVKALVEKCHRISSVVLIGAPHISDSAFKALSGCDIKKIRFEGNKRITDACFKLIDKSYPNISHIYMVDCKGITDGSLKSLSPLKHLTVLNLANCVRIGDTGLKQFLDGPASTKIRELNLSNCIHLGDASMAKLSERCYNLNYLNLRNCEHLTDLGVEFIANIFSLVSVDLSGTDISNEGLMTLSRHRKLKELSVSECDKITDFGIQVFCKGSLTLEHLDVSYCPQLSDIIIKALAIYCINLTSLSVAGCPKITDSAMEMLSAKCHYLHILDVSGCILLTDQMLENLEMGCRQLRILKMQYCRLISKEAAIRMSSIVQHQEYSASNPPLWFGYDSEGKSLREKQNTSLKNSELTAKESTYNNEEEAV", "length": 824, "header": "tr|E1BJI6-1|E1BJI6_BOVIN Isoform 1 of F-box and leucine-rich repeat protein 13 OS=Bos taurus OX=9913 GN=FBXL13 PE=3 SV=4 CANONICAL=E1BJI6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCW5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI6/entry#A0A3Q1MCW5-1", "sequence": { "sequence": "IFSYLSLRDLVICGQVNRSWLLMTQMGSLWNGIDFSAVKNIITDKYIVSILQRWRLNVLRLNFRGCALRLKTLRSVSFCKNLQELNVSDCPTLTDESMRYISESCPGVLYLNLSNTIITNRTMRLLPRYFYNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIANSCSGIMHLTINDMPTLTDNCVKALVEKCHRISSVVLIGAPHISDSAFKALSGCDIKKIRFEGNKRITDACFKLIDKSYPNISHIYMVDCKGITDGSLKSLSPLKHLTVLNLANCVRIGDTGLKQFLDGPASTKIRELNLSNCIHLGDASMAKLSERCYNLNYLNLRNCEHLTDLGVEFIANIFSLVSVDLSGTDISNEGLMTLSRHRKLKELSVSECDKITDFGIQITDSAMEMLSAKCHYLHILDVSGCILLTDQMLENLEMGCRQLRILKMQYCRLISKEAAIRMSSIVQHQEYSASNPPLWFGYDSEGKSLREKQNTSLKNSELTAKESTYNNEEEAV", "length": 523, "header": "tr|A0A3Q1MCW5-1|A0A3Q1MCW5_BOVIN Computationally mapped isoform of F-box and leucine rich repeat protein 13 OS=Bos taurus OX=9913 GN=FBXL13 PE=4 SV=2 CANONICAL=E1BJI6-1" }, "locus": { "chromosome": "4", "start_pos": 44292340, "end_pos": 44146963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083919.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083919.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068717.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068717.2" } ] } }, { "isoform_ac": "E1BJI6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJI6/entry#E1BJI6-1", "sequence": { "sequence": "MASLRRASPRLRKYFRENYIPQVCEALLCGLLVTCPEDPLRYLEEMIIGIMENGLETLLWDMCIDPLMKPKIRRLSETYLEQLFGLDDQLMTPELMIRACTFYTGRLLKTHFHTWREIAIPPTNEDELLAEKMEAAIVYANFRLKKHVLHHWHSYVKNRKEQLRDALLRIQKMFHCYKMIVTLNKWRDRARHKFKKREDELMLKHELQLQKFSKLKFKTSSKEEYFFPEQFVSEGFPVGGIPEFDISQLPKRAILQIFSYLSLRDLVICGQVNRSWLLMTQMGSLWNGIDFSAVKNIITDKYIVSILQRWRLNVLRLNFRGCALRLKTLRSVSFCKNLQELNVSDCPTLTDESMRYISESCPGVLYLNLSNTIITNRTMRLLPRYFYNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIANSCSGIMHLTINDMPTLTDNCVKALVEKCHRISSVVLIGAPHISDSAFKALSGCDIKKIRFEGNKRITDACFKLIDKSYPNISHIYMVDCKGITDGSLKSLSPLKHLTVLNLANCVRIGDTGLKQFLDGPASTKIRELNLSNCIHLGDASMAKLSERCYNLNYLNLRNCEHLTDLGVEFIANIFSLVSVDLSGTDISNEGLMTLSRHRKLKELSVSECDKITDFGIQVFCKGSLTLEHLDVSYCPQLSDIIIKALAIYCINLTSLSVAGCPKITDSAMEMLSAKCHYLHILDVSGCILLTDQMLENLEMGCRQLRILKMQYCRLISKEAAIRMSSIVQHQEYSASNPPLWFGYDSEGKSLREKQNTSLKNSELTAKESTYNNEEEAV", "length": 824, "header": "tr|E1BJI6-1|E1BJI6_BOVIN Isoform 1 of F-box and leucine-rich repeat protein 13 OS=Bos taurus OX=9913 GN=FBXL13 PE=3 SV=4 CANONICAL=E1BJI6-1" }, "locus": { "chromosome": "4", "start_pos": 44363428, "end_pos": 44146963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061011.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061011.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053855.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053855.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101905084", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905084", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "E1BJI6", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJI6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 824, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJI6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJI6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJI6" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 243, "end_pos": 289, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 273, "end_pos": 275 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 376, "end_pos": 378 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 698, "end_pos": 700 }, { "start_pos": 802, "end_pos": 804 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJL5-1", "uniprot_ac": "E1BJL5", "uniprot_id": "E1BJL5_BOVIN", "mass": { "chemical_mass": 32895.0, "monoisotopic_mass": 32895.0 }, "refseq": {}, "gene_names": [ { "name": "CLEC10A", "type": "recommended", "evidence": [ { "id": "E1BJL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ] } ], "protein_names": [ { "name": "C-type lectin domain containing 10A", "type": "synonym", "evidence": [ { "id": "E1BJL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC10A", "url": "https://www.uniprot.org/uniprotkb/E1BJL5", "locus": { "chromosome": "19", "start_pos": 26833296, "end_pos": 26837480, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017895", "url": "https://www.ensembl.org/id/ENSBTAG00000017895" } ] } } ], "crossref": [ { "id": "E1BJL5", "url": "https://alphafold.ebi.ac.uk/entry/E1BJL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017895", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017895", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514833", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514833", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GFKNGPP", "url": "https://omabrowser.org/oma/group/GFKNGPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJL5", "url": "https://www.orthodb.org/?gene=E1BJL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03954", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03954", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5621480", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJL5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVKYEDLQYLESEKKSQRFTEALFSSQTFLKRLLSSPCLLLLSLALSLLLASICVMGYQNFKFQSDLQTLRTSFSNFTSNSMAEVQALNSQGRSFQEMITSLKAEVESHKQELQAGDSEMLLRVQQLVKNLNSLTCKMDALKSNGKSCSQNTACCPANWLEHEGHCYWFSSLRKPWPEAEKDCQLKNAQLVVINSRDEQDFIQANLHPYFTWMGLSDPDGVWKWVDGSDYETNIKNWKPGQPDDFHGHGLGGGEDCAHFYPDGEWNDDACQRLYYWICEAGLSQGNES", "length": 289, "header": "tr|E1BJL5-1|E1BJL5_BOVIN Isoform 1 of C-type lectin domain containing 10A OS=Bos taurus OX=9913 GN=CLEC10A PE=4 SV=3 CANONICAL=E1BJL5-1" }, "isoforms": [ { "isoform_ac": "E1BJL5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJL5/entry#E1BJL5-1", "sequence": { "sequence": "MSVKYEDLQYLESEKKSQRFTEALFSSQTFLKRLLSSPCLLLLSLALSLLLASICVMGYQNFKFQSDLQTLRTSFSNFTSNSMAEVQALNSQGRSFQEMITSLKAEVESHKQELQAGDSEMLLRVQQLVKNLNSLTCKMDALKSNGKSCSQNTACCPANWLEHEGHCYWFSSLRKPWPEAEKDCQLKNAQLVVINSRDEQDFIQANLHPYFTWMGLSDPDGVWKWVDGSDYETNIKNWKPGQPDDFHGHGLGGGEDCAHFYPDGEWNDDACQRLYYWICEAGLSQGNES", "length": 289, "header": "tr|E1BJL5-1|E1BJL5_BOVIN Isoform 1 of C-type lectin domain containing 10A OS=Bos taurus OX=9913 GN=CLEC10A PE=4 SV=3 CANONICAL=E1BJL5-1" }, "locus": { "chromosome": "19", "start_pos": 26836213, "end_pos": 26833522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054378.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054378.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050861.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050861.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514833", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514833", "resource": "KEGG Pathway" }, { "id": "R-BTA-5621480", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "resource": "Reactome", "description": "Dectin-2 family" } ], "orthologs": [ { "uniprot_canonical_ac": "F8W3Q0-1", "protein_name": "Asialoglycoprotein receptor 1", "gene_name": "asgr1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRVVSSDSGSVTVANTEYTDETESAETSDHTEFWRGDPSVRRLAAVPSGGRWRWCAGIAGSVAALMLLLLIITVSVNHVKFNRKFSATEVRIQNLTQIILNVISRTQELEQFGHKINADVSSLEFDQRMTETSMNNLLESAQALHDKVSELKCHIDKMRNNNTQELCCPDQWSLFSSNCYFFSTDGMSWDSARDECERKRAKLLILTSKLEKSFVVSKTKPLFYWLGLTDGRTGEWEWLDETPYEMVRSEWRPGQPDNWKAHGLGGGEDCAHFHHDGRYNDDHCSRHYRYICKAAASAI", "length": 299 }, "evidence": [ { "id": "E1BJL5", "url": "https://omabrowser.org/oma/group/E1BJL5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P49300-1", "protein_name": "C-type lectin domain family 10 member A", "gene_name": "Clec10a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIYENLQNSRIEEKTQEPGKAPSQSFLWRILSWTHLLLFSLGLSLLLLVVVSVIGSQNSQLRRDLGTLRATLDNTTSKIKAEFQSLDSRADSFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTVEKREQALKTDLSDLTDHVQQLRKDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVVSWIGLTDQNGPWRWVDGTDFEKGFKNWAPLQPDNWFGHGLGGGEDCAHITTGGPWNDDVCQRTFRWICEMKLAKES", "length": 304 }, "evidence": [ { "id": "E1BJL5", "url": "https://omabrowser.org/oma/group/E1BJL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IUN9-1", "protein_name": "C-type lectin domain family 10 member A", "gene_name": "CLEC10A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH", "length": 316 }, "evidence": [ { "id": "E1BJL5", "url": "https://omabrowser.org/oma/group/E1BJL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "D-mannose binding", "id": "GO:0005537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005537", "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "pmid": "" }, { "name": "fucose binding", "id": "GO:0042806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042806", "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "E1BJL5", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 289, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJL5" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 280, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 287, "end_pos": 289 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJN0-1", "uniprot_ac": "E1BJN0", "uniprot_id": "E1BJN0_BOVIN", "mass": { "chemical_mass": 19865.0, "monoisotopic_mass": 19865.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Tetratricopeptide repeat protein 9C", "type": "recommended", "evidence": [ { "id": "E1BJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJN0", "url": "https://www.uniprot.org/uniprotkb/E1BJN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BJN0", "locus": {} } ], "crossref": [ { "id": "E1BJN0", "url": "https://alphafold.ebi.ac.uk/entry/E1BJN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030890", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030890", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJN0", "url": "https://www.orthodb.org/?gene=E1BJN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1BJN0", "url": "https://www.uniprot.org/uniprotkb/E1BJN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRLQEAQLYKEKGNQCYREGKYRDAVSGYHRALLQLRGLDPSLPSPIPNLGPQGLALTPEQENLLHTTQTDCYNNLAACLLQMEPVNYERVKEYSQKDVERQPDNAKALYRAGVAFFHLQDYDQARHYLMAAVNRKPKDANVRRYLQRTQLELSSYHRKEKQLYLGMFG", "length": 171, "header": "tr|E1BJN0-1|E1BJN0_BOVIN Isoform 1 of Tetratricopeptide repeat protein 9C OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1BJN0-1" }, "isoforms": [ { "isoform_ac": "E1BJN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN0/entry#E1BJN0-1", "sequence": { "sequence": "MGKRLQEAQLYKEKGNQCYREGKYRDAVSGYHRALLQLRGLDPSLPSPIPNLGPQGLALTPEQENLLHTTQTDCYNNLAACLLQMEPVNYERVKEYSQKDVERQPDNAKALYRAGVAFFHLQDYDQARHYLMAAVNRKPKDANVRRYLQRTQLELSSYHRKEKQLYLGMFG", "length": 171, "header": "tr|E1BJN0-1|E1BJN0_BOVIN Isoform 1 of Tetratricopeptide repeat protein 9C OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1BJN0-1" }, "locus": { "chromosome": "3", "start_pos": 76846049, "end_pos": 76829821, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043701.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043701.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050847.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050847.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJN0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 171, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJN0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJN0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJN6-1", "uniprot_ac": "E1BJN6", "uniprot_id": "E1BJN6_BOVIN", "mass": { "chemical_mass": 79009.0, "monoisotopic_mass": 79009.0 }, "refseq": { "ac": "NP_001178188", "name": "SEC14-like protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178188" }, "gene_names": [ { "name": "SEC14L5", "type": "recommended", "evidence": [ { "id": "E1BJN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" } ] }, { "name": "SEC14L5", "type": "synonym", "evidence": [ { "id": "NP_001178188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178188" } ] } ], "protein_names": [ { "name": "SEC14 like lipid binding 5", "type": "synonym", "evidence": [ { "id": "E1BJN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN6/entry#names_and_taxonomy" } ] }, { "name": "SEC14-like 5", "type": "synonym", "evidence": [ { "id": "NP_001178188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178188" } ] }, { "name": "SEC14-like protein 5", "type": "synonym", "evidence": [ { "id": "NP_001178188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178188" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJN6", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC14L5", "url": "https://www.uniprot.org/uniprotkb/E1BJN6", "locus": { "chromosome": "25", "start_pos": 4053073, "end_pos": 4013885, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007890", "url": "https://www.ensembl.org/id/ENSBTAG00000007890" } ] } } ], "crossref": [ { "id": "E1BJN6", "url": "https://alphafold.ebi.ac.uk/entry/E1BJN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007890", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007890", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "790103", "url": "https://www.ncbi.nlm.nih.gov/gene/790103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:790103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YHTKQVP", "url": "https://omabrowser.org/oma/group/YHTKQVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJN6", "url": "https://www.orthodb.org/?gene=E1BJN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NUB2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUB2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJN6", "url": "https://www.uniprot.org/uniprotkb/E1BJN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQKYQSPIRVYKHPFELVMVAYEKRFPTCPQIPVFLGSEVLRESRSADGAVHVVERSCRLRVEAPRLLCKIAGVEHVVFVQRNVLNWKERTLFIEAHNETFASRVVVKENCSYRVHPENEDWTCFEQSASLDIRSFFGFESALEKIAMRQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPALAREEDAPSQAGQREPDSLEVCGPSSAQDLAPESVSTDGDKLDADYIERCLGHLTPRQESCLVQLRRWLQETHKGKIPKDEHILRFLRARDFHLDRAREMLCQSLSWRKQHQVDLLLETWRPPALLEEFYAGGWHYQDIDGRPLYILRLGHMDTKGLMKAVGEEVLLRHILSVNEEGQKRCEGNTKQFGRPISSWTCLVDLEGLSLRHLWRPGVKALLRMIEVVEGNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRQKFLIYSGSNYQGPGGLVDYLDKDVIPDFLGGECLCNVPEGGLVPKSLYLTEEDQENEDQLWQWRETYHSASVLRGAPHEVTVEILERESVITWDFDILRGDVVFSLYHAKQASMPGPREPGARASGQLMDRGWALGANFSCVEAPLICREGESIQGSHVTRWPGIYLLQWQMHSPPAHMACSLPGVEDVLTALHSPGPRCKLLYYYEVLASEDFRGSMSSLESCTSRFSQLSAATSSSSAPSHSSSLVSR", "length": 695, "header": "tr|E1BJN6-1|E1BJN6_BOVIN Isoform 1 of SEC14 like lipid binding 5 OS=Bos taurus OX=9913 GN=SEC14L5 PE=4 SV=3 CANONICAL=E1BJN6-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NUB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN6/entry#A0ABI0NUB2-1", "sequence": { "sequence": "MVQKYQSPIRVYKHPFELVMVAYEKRFPTCPQIPVFLGSEVLRESRSADGAVHVVERSCRLRVEAPRLLCKIAGVEHVVFVQRNVLNWKERTLFIEAHNETFASRVVVKENCSYRVHPENEDWTCFEQSASLDIRSFFGFESALEKIAMRQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPALAREEDAPSQAGQREPDSLEVCGPSSAQDLAPESVSTDGDKLDADYIERCLGHLTPRQESCLVQLRRWLQETHKGKIPKDEHILRFLRARDFHLDRAREMLCQSLSWRKQHQVDLLLETWRPPALLEEFYAGGWHYQDIDGRPLYILRLGHMDTKGLMKAVGEEVLLRHILSVNEEGQKRCEGNTKQFGRPISSWTCLVDLEGLSLRHLWRPGVKALLRMIEVVEGNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRQKFLIYSGSNYQGPGGLVDYLDKDVIPDFLGGECLCNVPEGGLVPKSLYLTEEDQENEDQLWQWRETYHSASVLRGAPHEVTVEILERESVITWDFDILRGDVVFSLYHAKQASMPGPREPGARASGQLMDRGWALGANFSCVEAPLICREGESIQVFSWVIYSFITITQDRVSAACQGSGGTAVHRLDPVPGLRDPAGQ", "length": 644, "header": "tr|A0ABI0NUB2-1|A0ABI0NUB2_BOVIN Computationally mapped isoform of SEC14 like lipid binding 5 OS=Bos taurus OX=9913 GN=SEC14L5 PE=4 SV=1 CANONICAL=E1BJN6-1" }, "locus": { "chromosome": "25", "start_pos": 4048269, "end_pos": 4015613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143163.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143163.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104722.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104722.1" } ] } }, { "isoform_ac": "E1BJN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN6/entry#E1BJN6-1", "sequence": { "sequence": "MVQKYQSPIRVYKHPFELVMVAYEKRFPTCPQIPVFLGSEVLRESRSADGAVHVVERSCRLRVEAPRLLCKIAGVEHVVFVQRNVLNWKERTLFIEAHNETFASRVVVKENCSYRVHPENEDWTCFEQSASLDIRSFFGFESALEKIAMRQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPALAREEDAPSQAGQREPDSLEVCGPSSAQDLAPESVSTDGDKLDADYIERCLGHLTPRQESCLVQLRRWLQETHKGKIPKDEHILRFLRARDFHLDRAREMLCQSLSWRKQHQVDLLLETWRPPALLEEFYAGGWHYQDIDGRPLYILRLGHMDTKGLMKAVGEEVLLRHILSVNEEGQKRCEGNTKQFGRPISSWTCLVDLEGLSLRHLWRPGVKALLRMIEVVEGNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRQKFLIYSGSNYQGPGGLVDYLDKDVIPDFLGGECLCNVPEGGLVPKSLYLTEEDQENEDQLWQWRETYHSASVLRGAPHEVTVEILERESVITWDFDILRGDVVFSLYHAKQASMPGPREPGARASGQLMDRGWALGANFSCVEAPLICREGESIQGSHVTRWPGIYLLQWQMHSPPAHMACSLPGVEDVLTALHSPGPRCKLLYYYEVLASEDFRGSMSSLESCTSRFSQLSAATSSSSAPSHSSSLVSR", "length": 695, "header": "tr|E1BJN6-1|E1BJN6_BOVIN Isoform 1 of SEC14 like lipid binding 5 OS=Bos taurus OX=9913 GN=SEC14L5 PE=4 SV=3 CANONICAL=E1BJN6-1" }, "locus": { "chromosome": "25", "start_pos": 4052069, "end_pos": 4015613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046931.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046931.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044178.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044178.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:790103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790103", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A8B0-1", "protein_name": "SEC14-like lipid binding 5", "gene_name": "Sec14l5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVQKYQSPVRVYKYPFELVMAAYEKRFPTCPLIPVFLGSEVLSECRSADGAVHTVERSCRLRVDAPRLLRKIAGVEHVVFIQRNVLNWRERTLLIDAHNETFASRVTVKEHCRYTVHPENEDWTCFEQSASLDVRSFFGFESTLEKIAMKQYTANVKRGKEVIEHYLSELISQGASHIPRWTPAPVREADVRSQLVCPCPSSLETDGPSDAPAPASEMATADGDKLDADYIERCLGHLSPMQESCLVQLRRWLQETHKGKIPKDEHILRFLRARDFHLDKARDMLCQSLSWRKQHQVDLLLQTWRPPAPLQEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLQHVLSVNEEGQKRCEGNTRQFGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLVSPFINENTRRKFLIYSGSNYQGPGGLVDYLDKDVIPDFLGGESVCNVPEGGMVPKSLYLTEEEQEQADQLRQWSETYHSASVLRGSPHEVAMEIPEGESVITWDFDILRGDVVFSLYHAKQAPKLSPQEPGVRASGQLIDKNWILGVDYSRVEAPLICREGQSIQGSHVTQWPGVYLLQWQIHSPPESVACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCASRFSQLSATTTSSSSGQSHSGSMVSR", "length": 696 }, "evidence": [ { "id": "E1BJN6", "url": "https://omabrowser.org/oma/group/E1BJN6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RK91-1", "protein_name": "SEC14 like lipid binding 5", "gene_name": "SEC14L5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVQKYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSEVLHESRSADGAVHVVERSCRLRVEAPRLLRKIAGVEHVVFVQRNVLNWKERTLLIEAHNETLASRVVVKENCSYTVHPENEEWTCFEQSASLDIRSFFGFESALEKIAMKQYTANIKRGKEVIEHYLKELISQGTSHIPRWTPAPVPQEDAHPQGGLRDPGSLEVCRPGSAGGPSTETVGTEGDKLDTDYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKDEHILRFLRARDFHLERAWEMLCQSLSWRKQHQVDLLLQTWRPPALLQEFYAGGWHYQDIDGRPLYILRLGHMDTKGLMKAVGEEVLLQHVLSVNEEGQKRCEGNTKQFGRPISSWTCLVDLEGLSLRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRQKFLIYSGSNYQGPGGLVDYLDKDVIPDFLGGECLCNIPEGGLVPKSLYMTEEDQEHEDQLRQWTETYQSASVLRGSPHEVVVEIVERESVITWDFDILRGDVLFSLYHAKQAPTLGPQEPGARAGGQQTDKGRALGGDYSRVEAPLVCREGDSIQGSHVTRWPGVYLLQWQMHSAPGHGACSLPGVEDVLTALQSPGPRCRLLYYYEVLASEDFRGSMSSLESCTSRFSQLSAATSSSSSGHSHSSSLVSR", "length": 696 }, "evidence": [ { "id": "E1BJN6", "url": "https://omabrowser.org/oma/group/E1BJN6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O43304-1", "protein_name": "SEC14-like protein 5", "gene_name": "SEC14L5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVQRYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSEVLRESRSPDGAVHVVERSCRLRVDAPRLLRKIAGVEHVVFVQTNILNWKERTLLIEAHNETFANRVVVNEHCSYTVHPENEDWTCFEQSASLDIRSFFGFENALEKIAMKQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPAPVREEDARNQAGPRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWRKQHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLWQWSETYHSASVLRGAPHEVAVEILEGESVITWDFDILRGDVVFSLYHTKQAPRLGAREPGTRASGQLIDKGWVLGRDYSRVEAPLVCREGESIQGSHVTRWPGVYLLQWQMHSPPSSVACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCTSGFSQLSAATSSSSSGQSHSSSLVSR", "length": 696 }, "evidence": [ { "id": "E1BJN6", "url": "https://omabrowser.org/oma/group/E1BJN6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJN6", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJN6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 695, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJN6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJN6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" }, { "id": "PS50191", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRAL-TRIO", "eco_id": "ECO_0000259", "start_pos": 306, "end_pos": 482, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 509, "end_pos": 653, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN6" }, { "id": "PS50904", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50904" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PRELI/MSF1", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 175, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJN9-1", "uniprot_ac": "E1BJN9", "uniprot_id": "E1BJN9_BOVIN", "mass": { "chemical_mass": 61066.0, "monoisotopic_mass": 61066.0 }, "refseq": { "ac": "NP_001192307", "name": "inactive phospholipase D5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192307" }, "gene_names": [ { "name": "PLD5", "type": "recommended", "evidence": [ { "id": "E1BJN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN9" } ] }, { "name": "PLD5", "type": "synonym", "evidence": [ { "id": "NP_001192307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192307" } ] } ], "protein_names": [ { "name": "Phospholipase D family member 5", "type": "synonym", "evidence": [ { "id": "E1BJN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN9/entry#names_and_taxonomy" } ] }, { "name": "inactive phospholipase D5", "type": "synonym", "evidence": [ { "id": "NP_001192307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192307" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJN9", "url": "https://www.uniprot.org/uniprotkb/E1BJN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLD5", "url": "https://www.uniprot.org/uniprotkb/E1BJN9", "locus": { "chromosome": "16", "start_pos": 34853620, "end_pos": 34429350, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033056", "url": "https://www.ensembl.org/id/ENSBTAG00000033056" } ] } } ], "crossref": [ { "id": "E1BJN9", "url": "https://alphafold.ebi.ac.uk/entry/E1BJN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033056", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033056", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09149", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09149", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617120", "url": "https://www.ncbi.nlm.nih.gov/gene/617120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032803", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032803", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617120", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617120", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETRYWPY", "url": "https://omabrowser.org/oma/group/ETRYWPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJN9", "url": "https://www.orthodb.org/?gene=E1BJN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10185:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10185:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13918", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13918", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192307", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJN9", "url": "https://www.uniprot.org/uniprotkb/E1BJN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLSMAKKSVDIVSSHWDLNHSHPSACQGQRLFEKLLQLTSQSIEIKLVSDVTADSKVLEALKSKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWRSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVMDYLPISSTSTKRTYWPDLDGKIREALVLRSVKVRLLISFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACIRKEQRNHTFPRLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRNNTSIIKQLKDVFERDWYSPYARTLQPTKQPNCSSLFRLRLPSNKTAMYNASGKDP", "length": 533, "header": "tr|E1BJN9-1|E1BJN9_BOVIN Isoform 1 of Phospholipase D family member 5 OS=Bos taurus OX=9913 GN=PLD5 PE=3 SV=3 CANONICAL=E1BJN9-1" }, "isoforms": [ { "isoform_ac": "E1BJN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJN9/entry#E1BJN9-1", "sequence": { "sequence": "MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLSMAKKSVDIVSSHWDLNHSHPSACQGQRLFEKLLQLTSQSIEIKLVSDVTADSKVLEALKSKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWRSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVMDYLPISSTSTKRTYWPDLDGKIREALVLRSVKVRLLISFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACIRKEQRNHTFPRLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRNNTSIIKQLKDVFERDWYSPYARTLQPTKQPNCSSLFRLRLPSNKTAMYNASGKDP", "length": 533, "header": "tr|E1BJN9-1|E1BJN9_BOVIN Isoform 1 of Phospholipase D family member 5 OS=Bos taurus OX=9913 GN=PLD5 PE=3 SV=3 CANONICAL=E1BJN9-1" }, "locus": { "chromosome": "16", "start_pos": 34852733, "end_pos": 34429413, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046923.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046923.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044170.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044170.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617120", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617120", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C1H9-1", "protein_name": "Phospholipase D family member 5", "gene_name": "PLD5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEVRHDWLSSSPHEGFEQMRLKSRPREPSPSLTRVGANFYSTVKQQDYSASVWLRRKDKLEHSQQRCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNNCRVALVENIPEGINYSDSAPSHLSLFQGWMNLLNMAEKSVDIVSSQWDLNHSHPSACQGQRLFEKLLELASRNIEIKLVSDILPVESKVLNDLKSKGAEVLYMNMSAYNEGRLQSSFWIVDKQHVYIGSASLDWRSLGQMKELGVIVYNCSCLVLDLQRIFALYSSLKYKNKIPPSWSKRLYGVYDTQNKLTLQLNETKSEAFVSNSPKLFCPKDRVLDIEAIYNVIDDAKQFVYIAVMDYLPIVIDTNAKRYWPFLDGKIREALVLRSIKVRLLISFSRDTDPLTFNFVSSLKAICTEVPSCSLKVKFFDLEEESACFLKDQKNASLPKLNRNKYMVTDGAAYIGNFDWVGNAFTQNAGAGLVINQADAGNSTSIIKQLKAVFERDWYSHYAKSLQPTKMPNCFNHKLSKATSNKTAMSNVN", "length": 529 }, "evidence": [ { "id": "E1BJN9", "url": "https://omabrowser.org/oma/group/E1BJN9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1MA92-1", "protein_name": "Phospholipase D family, member 5", "gene_name": "Pld5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAVLVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSEDAPFHLPLFQGWMNLLNMAKKSVDIVSSHWDLNHTHPSACQGQRLFEKLLQLTSQNIEVKLVSDVTADSKVLEALKLKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWRSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVTDYLPISSTSTKRTYWPDLDGKIREALVLRSVKVRLLISFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACATKEQKNQTFPKLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRDNRSIIKQLKDVFERDWYSPYAKSIQPTKQPNCSNLSKLKTPSNQPAIYNTTGREPLSV", "length": 536 }, "evidence": [ { "id": "E1BJN9", "url": "https://omabrowser.org/oma/group/E1BJN9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S8N8-1", "protein_name": "Phospholipase D family member 5", "gene_name": "PLD5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEIRQHEWLSASPHDGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVVFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLNMAKKSVDIVSSHWDLNHSHPSACQGQRLFEKLLQLTSESVEIKLVSDVTADSKVLEALKSKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWQSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVTDYLPISSTSTKRTYWPDLDGKIREALVLRSVKVRLLISFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACVTTKEQKNHTFPKLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRNNTSIIKQLKDVFERDWYSPYARTLQPTKQPNCSGLFKLRPPSNKTATYNASGKDPSSVSSE", "length": 540 }, "evidence": [ { "id": "E1BJN9", "url": "https://omabrowser.org/oma/group/E1BJN9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UNN8-1", "protein_name": "Inactive phospholipase D5", "gene_name": "Pld5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAVLVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSEDAPFHLPLFQGWMNLLNMAKKSVDIVSSHWDLNHTHPAACQGQRLFEKLLQLTSQNIEVKLVSDVTADSKVLEALKLKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWRSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVTDYLPISSTSSKRTYWPDLDGKIREALVLRSVKVRLLISFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACATKEQKNQTFPKLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRDNRSIIKQLKDVFERDWYSPYAKSIQPTKQPNCSSLSKLKSPSKQPAMANATGREPLSV", "length": 536 }, "evidence": [ { "id": "E1BJN9", "url": "https://omabrowser.org/oma/group/E1BJN9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N7P1-1", "protein_name": "Inactive phospholipase D5", "gene_name": "PLD5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLNMAKKSVDIVSSHWDLNHTHPSACQGQRLFEKLLQLTSQNIEIKLVSDVTADSKVLEALKLKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWQSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVMDYLPISSTSTKRTYWPDLDAKIREALVLRSVRVRLLLSFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACATKEQKNHTFPRLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRNNRSIIKQLKDVFERDWYSPYAKTLQPTKQPNCSSLFKLKPLSNKTATDDTGGKDPRNV", "length": 536 }, "evidence": [ { "id": "E1BJN9", "url": "https://omabrowser.org/oma/group/E1BJN9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "E1BJN9", "url": "https://www.uniprot.org/uniprotkb/E1BJN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 478, "end_pos": 480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJN9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJN9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJN9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJN9" }, { "id": "PS50035", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PLD phosphodiesterase", "eco_id": "ECO_0000259", "start_pos": 215, "end_pos": 242, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 157, "end_pos": 159 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 302, "end_pos": 304 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 478, "end_pos": 480 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 509, "end_pos": 511 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 527, "end_pos": 529 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJS8-1", "uniprot_ac": "E1BJS8", "uniprot_id": "E1BJS8_BOVIN", "mass": { "chemical_mass": 34883.0, "monoisotopic_mass": 34883.0 }, "refseq": { "ac": "NP_001377652", "name": "olfactory receptor 10G3", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377652" }, "gene_names": [ { "name": "OR10G3", "type": "recommended", "evidence": [ { "id": "E1BJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ] }, { "name": "OR10G3", "type": "synonym", "evidence": [ { "id": "NP_001377652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377652" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily G member 3", "type": "synonym", "evidence": [ { "id": "E1BJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10G3", "type": "synonym", "evidence": [ { "id": "NP_001377652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377652" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377652" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10G3", "url": "https://www.uniprot.org/uniprotkb/E1BJS8", "locus": { "chromosome": "10", "start_pos": 25599521, "end_pos": 25598580, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024752", "url": "https://www.ensembl.org/id/ENSBTAG00000024752" } ] } } ], "crossref": [ { "id": "E1BJS8", "url": "https://alphafold.ebi.ac.uk/entry/E1BJS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "101904323", "url": "https://www.ncbi.nlm.nih.gov/gene/101904323", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904323", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IYYVPCA", "url": "https://omabrowser.org/oma/group/IYYVPCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJS8", "url": "https://www.orthodb.org/?gene=E1BJS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001377652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377652", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJS8-1", "url": "https://www.uniprot.org/uniprotkb/E1BJS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERINSTLLTEFILTGIPYPPQLRTFLFGFFLLIYILTQLGNLLILITVCVDPQLHARPMYIFLGILSIIDMGIPSIVVPRLMMNFTLGFKPIPYGGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICRPLHYPMLMNAKLSTLLVAGAWAAGSMHGALQAILTFHLPYCGPNQVDYFFCDIPAVLRLACADTSVNELVTFVDIGVVVASCFSLILLSYIQIIQAILRIRTADGRRRAFSTCGAHVTMVTVYYVPCAFIYLRPETNSPLDGAAALFPTAITPFLNPLIYTLRNQEVKLALKRMIGGTGTKSEV", "length": 313, "header": "tr|E1BJS8-1|E1BJS8_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily G member 3 OS=Bos taurus OX=9913 GN=OR10G3 PE=3 SV=1 CANONICAL=E1BJS8-1" }, "isoforms": [ { "isoform_ac": "E1BJS8-1", "url": "https://www.uniprot.org/uniprotkb/E1BJS8/entry#E1BJS8-1", "sequence": { "sequence": "MERINSTLLTEFILTGIPYPPQLRTFLFGFFLLIYILTQLGNLLILITVCVDPQLHARPMYIFLGILSIIDMGIPSIVVPRLMMNFTLGFKPIPYGGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICRPLHYPMLMNAKLSTLLVAGAWAAGSMHGALQAILTFHLPYCGPNQVDYFFCDIPAVLRLACADTSVNELVTFVDIGVVVASCFSLILLSYIQIIQAILRIRTADGRRRAFSTCGAHVTMVTVYYVPCAFIYLRPETNSPLDGAAALFPTAITPFLNPLIYTLRNQEVKLALKRMIGGTGTKSEV", "length": 313, "header": "tr|E1BJS8-1|E1BJS8_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily G member 3 OS=Bos taurus OX=9913 GN=OR10G3 PE=3 SV=1 CANONICAL=E1BJS8-1" }, "locus": { "chromosome": "10", "start_pos": 25599518, "end_pos": 25598580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028534.4", "url": "https://www.ensembl.org/id/ENSBTAT00000028534.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028534.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028534.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101904323", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904323", "resource": "KEGG Pathway" }, { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UYS6-1", "protein_name": "Olfactory receptor family 10 subfamily G member 3", "gene_name": "OR10G3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERVNSTLLTEFFLTGIPYPPQLRTFLFVFFLLIYVLTQLGNLLILITVWVDPQLHARPMYIFLGVLSIIDMGISSIIVPRLMMNFTLDIKPIPFAGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICQPLRYPVLMNAKLSSLLVAGAWVAGSLHGALQAILTFRLPYCGPNQVNYFFCDIPAVLRLACADTTVNELVTFVDIGVVVASCFSLILLSYVQIIQAILRIRTADGRRRAFSTCGAHVIVVTVYYVPCAFIYLRPETNSPLDGAAALFPTAITPFLNPLIYTLRNQEVKLALKRMIGGPRTKSEV", "length": 313 }, "evidence": [ { "id": "E1BJS8", "url": "https://omabrowser.org/oma/group/E1BJS8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZVH4-1", "protein_name": "Olfactory receptor family 10 subfamily G member 3", "gene_name": "Or10g3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERVNHTLLTEFVLTGVPHPPRLRTFLFVFFLLIYILTQLGNMLILITVCADTQLHARPMYVFLGALSVIDMGISTIIVPRLMMNFTPGIKPIPFGGCVAQLYFYHFLGSSQCFLYTTMAYDRYLAICQPLRYPVLMSAKLSILLVAGAWVAGSIHGAIQAILTFRLPYCGPNQVDYFFCDIPAVLKLACADTTVNELVTFVDIGVVVASCFSLILLSYIYIIRAILRIRTADGRRRAFSTCGAHVTIVTVYYVPCAFIYLRPDSHSILDGAAALFPTAITPFLNPLIYTLRNQEVKTALRRMVGRQSTKSEV", "length": 313 }, "evidence": [ { "id": "E1BJS8", "url": "https://omabrowser.org/oma/group/E1BJS8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HWR9-1", "protein_name": "Olfactory receptor 10G3", "gene_name": "LOC100773730", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MERVNYTLLTEFILTGVPHPPRLRTFLLVFFLLIYILTQLGNLLILITVSADTQLHARPMYIFLGALSIIDMGISTIIVPRLMMNFTLGVKPIPFGGCVAQLYFYHFLGSSQCFLYTTMAYDRYLAICQPLRYPVLMSAKLSTLLVAGAWVAGSIHGAIQAILTFRLPYCGPNQVDYFFCDIPAVLKLACADTTVNELVTFVDIGVVVASCFSLILLSYIYIIRAILRIRTADGRRRAFSTCGAHVTIVTVYYVPCAFIYLRPDSHSVLDGAAALFPTAITPFLNPLIYTLRNQEVKLALRRMIGGQRAKSEV", "length": 313 }, "evidence": [ { "id": "E1BJS8", "url": "https://omabrowser.org/oma/group/E1BJS8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8NGC4-1", "protein_name": "Olfactory receptor 10G3", "gene_name": "OR10G3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERINSTLLTAFILTGIPYPLRLRTLFFVFFFLIYILTQLGNLLILITVWADPRLHARPMYIFLGVLSVIDMSISSIIVPRLMMNFTLGVKPIPFGGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICQPLRYPVLMTAKLSALLVAGAWMAGSIHGALQAILTFRLPYCGPNQVDYFFCDIPAVLRLACADTTVNELVTFVDIGVVVASCFSLILLSYIQIIQAILRIHTADGRRRAFSTCGAHVTVVTVYYVPCAFIYLRPETNSPLDGAAALVPTAITPFLNPLIYTLRNQEVKLALKRMLRSPRTPSEV", "length": 313 }, "evidence": [ { "id": "E1BJS8", "url": "https://omabrowser.org/oma/group/E1BJS8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VF72-1", "protein_name": "Olfactory receptor family 10 subfamily G member 3", "gene_name": "Or10g3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERINYTVLTEFILTGVPHPPRLRTFLFVFFLLIYILTQLGNALILITVCADTQLHARPMYIFLGALSVIDMGISTIIVPRLMMNFTPGIKPIPFGGCVAQLYFYHFLGSSQCFLYTTMAYDRYLAICQPLRYPVLMSAKLSILLVAGAWVAGSIHGAIQAILTFRLPYCGPNQVDYFFCDIPAVLKLACADTTVNELVTFVDIGVVVASCFSLILLSYIYIIRAILRIRTADGRRRAFSTCGAHVTIVTVYYVPCAFIYLRPDSHSILDGAAALFPTAITPFLNPLIYTLRNQEVKLALRRMVGSQSTKSEV", "length": 313 }, "evidence": [ { "id": "E1BJS8", "url": "https://omabrowser.org/oma/group/E1BJS8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BJS8", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJS8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJV2-1", "uniprot_ac": "E1BJV2", "uniprot_id": "E1BJV2_BOVIN", "mass": { "chemical_mass": 101025.0, "monoisotopic_mass": 101025.0 }, "refseq": {}, "gene_names": [ { "name": "C22H3orf20", "type": "recommended", "evidence": [ { "id": "E1BJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV2" } ] } ], "protein_names": [ { "name": "Chromosome 22 C3orf20 homolog", "type": "synonym", "evidence": [ { "id": "E1BJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJV2", "url": "https://www.uniprot.org/uniprotkb/E1BJV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C22H3orf20", "url": "https://www.uniprot.org/uniprotkb/E1BJV2", "locus": { "chromosome": "22", "start_pos": 57544168, "end_pos": 57595868, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040133", "url": "https://www.ensembl.org/id/ENSBTAG00000040133" } ] } } ], "crossref": [ { "id": "E1BJV2", "url": "https://alphafold.ebi.ac.uk/entry/E1BJV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040133", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040133", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJV2", "url": "https://www.orthodb.org/?gene=E1BJV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23093", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23093", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23093:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23093:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14977", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14977", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJV2", "url": "https://www.uniprot.org/uniprotkb/E1BJV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNEIKSNRELYLQYTATAPKLLAHISRLLISCRNAGVSVPKGIRNIFEFTWEELISDPMIPTPSDILGLEISIGAPPVMLMESAPVQTPVQKKPPPPALPLPMLPASTGLAKFTHSPTHGRRRQSSQEILHRFQRQSIHLLTELLSLKMKAMLESVSVGANPLDITKRFVEASQLLHLNAKEMAFDFLIGTIGRNSGSAGQTGKDSFTNIPAMGVNSPYQLVYEASTGCLSFSLSTGREFKKKTGKPKNTDDALASPQRGAGAGTSASEVIELNDPCPEAREKLQEMCRIIEAERVSWKGRNIFYPIIIRNYRAKMPPHLMSTPKGDAQTQSSHHPHPPGAQTYAPAPHQPPAHHLHSGRHSLEWKGPRKVIKLHYSFYDGSSFVYYPSGNIAMCQIPTCCRGRAITCLFNDTPSFSFLALFNAEGQGCVHYNLKARCPYVLVLDEEGGITNDQKGYVVHKWSWTSKTETLLSLEYKVNEQMKLTVLGQDAMMVTFTSMNETVTLPISASNCPHGISHDKRITRRISIMDEKISKMSRALAEIKRRFQKTVSQFMNSILLAAGLFTIKYPVKEEAEVNRTRLKSGLFPERSTKLSLYSGDMLLLRSQSARPESLIEVASKEEPESAPVSPTRKKPSKFHTKAMAPRRGKAREVRSPTRWAASLSDCPLVLRKLISKEDIRAGCRCLVRAPLVSDVELERFLSAPRDPSQVLVFGVVSGQNPTSSGQLQWLLDMLYSHRQQGRASPCIQCRHDPYRLLCYDLDSPLQRDPPLLVKKYAVMQGMILMFAGGKLLFGGCVLNGYGFSRQNLLKQIFQARQDCKMGYFLPENYKFSILASVPGLEDPTSSKKAVSGDVQGSLSSLALGDKLEEPSTEAERKIIQADLDLRALNKAWKSNKKTATWKKQASKK", "length": 908, "header": "tr|E1BJV2-1|E1BJV2_BOVIN Isoform 1 of Chromosome 22 C3orf20 homolog OS=Bos taurus OX=9913 GN=C22H3orf20 PE=4 SV=3 CANONICAL=E1BJV2-1" }, "isoforms": [ { "isoform_ac": "E1BJV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV2/entry#E1BJV2-1", "sequence": { "sequence": "MNEIKSNRELYLQYTATAPKLLAHISRLLISCRNAGVSVPKGIRNIFEFTWEELISDPMIPTPSDILGLEISIGAPPVMLMESAPVQTPVQKKPPPPALPLPMLPASTGLAKFTHSPTHGRRRQSSQEILHRFQRQSIHLLTELLSLKMKAMLESVSVGANPLDITKRFVEASQLLHLNAKEMAFDFLIGTIGRNSGSAGQTGKDSFTNIPAMGVNSPYQLVYEASTGCLSFSLSTGREFKKKTGKPKNTDDALASPQRGAGAGTSASEVIELNDPCPEAREKLQEMCRIIEAERVSWKGRNIFYPIIIRNYRAKMPPHLMSTPKGDAQTQSSHHPHPPGAQTYAPAPHQPPAHHLHSGRHSLEWKGPRKVIKLHYSFYDGSSFVYYPSGNIAMCQIPTCCRGRAITCLFNDTPSFSFLALFNAEGQGCVHYNLKARCPYVLVLDEEGGITNDQKGYVVHKWSWTSKTETLLSLEYKVNEQMKLTVLGQDAMMVTFTSMNETVTLPISASNCPHGISHDKRITRRISIMDEKISKMSRALAEIKRRFQKTVSQFMNSILLAAGLFTIKYPVKEEAEVNRTRLKSGLFPERSTKLSLYSGDMLLLRSQSARPESLIEVASKEEPESAPVSPTRKKPSKFHTKAMAPRRGKAREVRSPTRWAASLSDCPLVLRKLISKEDIRAGCRCLVRAPLVSDVELERFLSAPRDPSQVLVFGVVSGQNPTSSGQLQWLLDMLYSHRQQGRASPCIQCRHDPYRLLCYDLDSPLQRDPPLLVKKYAVMQGMILMFAGGKLLFGGCVLNGYGFSRQNLLKQIFQARQDCKMGYFLPENYKFSILASVPGLEDPTSSKKAVSGDVQGSLSSLALGDKLEEPSTEAERKIIQADLDLRALNKAWKSNKKTATWKKQASKK", "length": 908, "header": "tr|E1BJV2-1|E1BJV2_BOVIN Isoform 1 of Chromosome 22 C3orf20 homolog OS=Bos taurus OX=9913 GN=C22H3orf20 PE=4 SV=3 CANONICAL=E1BJV2-1" }, "locus": { "chromosome": "22", "start_pos": 57595689, "end_pos": 57544718, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008930.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008930.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008930.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008930.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BJV2", "url": "https://www.uniprot.org/uniprotkb/E1BJV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 908, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJV2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV2" }, { "id": "PF14977", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14977" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM194 C-terminal", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 568, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 411, "end_pos": 413 }, { "start_pos": 500, "end_pos": 502 }, { "start_pos": 578, "end_pos": 580 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJV3-1", "uniprot_ac": "E1BJV3", "uniprot_id": "E1BJV3_BOVIN", "mass": { "chemical_mass": 53253.0, "monoisotopic_mass": 53253.0 }, "refseq": { "ac": "NP_001192651", "name": "microtubule-associated tyrosine carboxypeptidase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" }, "gene_names": [ { "name": "MATCAP1", "type": "recommended", "evidence": [ { "id": "E1BJV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ] }, { "name": "KIAA0895L", "type": "synonym", "evidence": [ { "id": "NP_001192651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" } ] }, { "name": "MATCAP1", "type": "synonym", "evidence": [ { "id": "NP_001192651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" } ] } ], "protein_names": [ { "name": "KIAA0895 like", "type": "synonym", "evidence": [ { "id": "NP_001192651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" } ] }, { "name": "KIAA0895-like ortholog", "type": "synonym", "evidence": [ { "id": "NP_001192651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" } ] }, { "name": "Microtubule associated tyrosine carboxypeptidase 1", "type": "synonym", "evidence": [ { "id": "E1BJV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV3/entry#names_and_taxonomy" } ] }, { "name": "microtubule-associated tyrosine carboxypeptidase 1", "type": "synonym", "evidence": [ { "id": "NP_001192651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MATCAP1", "url": "https://www.uniprot.org/uniprotkb/E1BJV3", "locus": { "chromosome": "18", "start_pos": 34813277, "end_pos": 34820215, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003521", "url": "https://www.ensembl.org/id/ENSBTAG00000003521" } ] } } ], "crossref": [ { "id": "E1BJV3", "url": "https://alphafold.ebi.ac.uk/entry/E1BJV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003521", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003521", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512420", "url": "https://www.ncbi.nlm.nih.gov/gene/512420", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512420", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512420", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RILQPPW", "url": "https://omabrowser.org/oma/group/RILQPPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJV3", "url": "https://www.orthodb.org/?gene=E1BJV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31817:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31817:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLDSGAQVYEQAPPSPPASPSSLAHRPGPSDQDGTALFPWPQSLALPLALSVPSALRPRAERQPFSELHLGRRGHMRRSESTYTVNSTGRRGGSTQSWAPPGRGRDPGGGTLRPAASLPHIAKARKEAGRGASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRRYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHSAEGRQQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLARYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGILRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMTTNRLDEAELGRLLPD", "length": 471, "header": "tr|E1BJV3-1|E1BJV3_BOVIN Isoform 1 of Microtubule associated tyrosine carboxypeptidase 1 OS=Bos taurus OX=9913 GN=MATCAP1 PE=4 SV=1 CANONICAL=E1BJV3-1" }, "isoforms": [ { "isoform_ac": "E1BJV3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV3/entry#E1BJV3-1", "sequence": { "sequence": "MVLDSGAQVYEQAPPSPPASPSSLAHRPGPSDQDGTALFPWPQSLALPLALSVPSALRPRAERQPFSELHLGRRGHMRRSESTYTVNSTGRRGGSTQSWAPPGRGRDPGGGTLRPAASLPHIAKARKEAGRGASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRRYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHSAEGRQQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLARYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGILRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMTTNRLDEAELGRLLPD", "length": 471, "header": "tr|E1BJV3-1|E1BJV3_BOVIN Isoform 1 of Microtubule associated tyrosine carboxypeptidase 1 OS=Bos taurus OX=9913 GN=MATCAP1 PE=4 SV=1 CANONICAL=E1BJV3-1" }, "locus": { "chromosome": "18", "start_pos": 34817265, "end_pos": 34813493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004579.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004579.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004579.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004579.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512420", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512420", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZY40-1", "protein_name": "Microtubule associated tyrosine carboxypeptidase 1", "gene_name": "MATCAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLDSGAQVYEQAPPSPPASPSSLGHRLKPSDRDGTALYPWPQSLALPLALSVPSALRPQPELQPFSELHLGIRGHMRRSESTYTVNSTGRRGGSTQGRAPPGRGRDPGGGTLRSAASLPHIAKTRKDAGRGGSKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNAQQPWHSAEGRLQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLARYVEDADVRWEYCVRAKRGQTDTSRPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD", "length": 471 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E7F2R7-1", "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1 isoform X1", "gene_name": "kiaa0895l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLDLGENCMEQANRGGLTNNVSEMLEPEPSPEKPKPVRARTSSITQRDKAAHNGPHVPTCTSGESSSQVQRRLQKTESRNKGEQPLCRRPLSLEIKPQRVRAAQPAVQKTMKPPWRTGGPSPPMRSLTSLSLGPGNWLRRSESTCTMISSTPPRAGRAQMRPATSLPHIARGIASLPSPSTPRGPCLLVALRPVNLEQERQTFFQSDYQYEPQFEYSSPEPVSVLEKYKEGSSLFLSQAVGIMECVLRKYETYENFEEVTGGNLLPKSQVWAATRKYLQKEGCVGEVVVSLSDELLSQAVMMVERCRPTLTINLSGARQHWLEGMLRHEIGTHYLRGVNNSMQPWATSVGRKQFGLKPANPTEEGLASLHSVLLRKQPFLWRAALLYYTVYHATNMSFSQLFSHIARFVQDPAVRWEYCLRAKRGQTDTSKPGCFSKDQVYLDGILRILRHRRNIDFKILTALGKVSYEDVERLRHSAVLHGTRIPHFMQDEERYLQHLDHIVTVNELSDAELRELIP", "length": 519 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HZK8-1", "protein_name": "Uncharacterized protein KIAA0895-like homolog", "gene_name": "Kiaa0895l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLDSGAQVYERAPPSPPASPPSQCHRLKSSNRNGPPLYPWPQSLAMPLALAVPSTLQSQPMWKTFSQLQLRQRSHMRRSESTYNVNSTGQRGRGKTPRVCDPSGGTLRPAASLPHIAKTRKDLGNGGSKSPCMLVALRPTNMDQERDKFFQSHYTYNPQFEYQEPMPMSVLEKYQEASGQFIQQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCVGEVVVQLSENLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNSRQPWHSTEGRLQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHQAAHMSFRQLFQDLAQYVQDEAVRWEYCVRAKRGQTDTSRPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDQLRPHGILDNARVPHFMKDLGRYRQQLEYIMATNRLDEAELGRLLPD", "length": 466 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4V7A9-1", "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1", "gene_name": "Matcap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLDSGTQVYEQAPPSPPASSPSQHHKLKPSNRNGPPLYPWPQSLAMPLALAVPSALQHQTMWQTFSKLHLEQRSHMKRSESTYSVNSTGRRGRGKAPLGRGCDPGGGTLRPAASLPHIAKIRKDVVSGSNKSPCMLVALRPTNMDQEREKFFQSHYAYNPQFEYQEPMPMSVLEKYQEASGQFMHQAVGIIKAVLEKFGTYENFEAATGGQLLTKCQIWSIVRRYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNSRQPWHSTEGRQQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHQAAHMSFRQLFQDLEQYVQDEDVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGILRILRHRQTIDFQLLTSLGKVSYEDVEQLRPHGVLDKTRVPHFMKDLDRYRQQLEHIMTTNRLDEAELGRLLPD", "length": 468 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q68EN5-1", "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1", "gene_name": "MATCAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD", "length": 471 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q810A5-1", "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1", "gene_name": "Matcap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLDSGTQVYEQAPPRPPAGSPSQHHKLKPSNGNGPPLYPWPESLGMPLALAVPSALQQQTMWQTFSKLHLEQSSHMRRSESTYSVNSTGRRGRGKAPIGRGCDPGGTLRPAASLPHIAKIRKDVGSSSSKSPCMLVALRPTNMDQEREKFFQSHYTYNPQFEYQEPMPMSVLEKYQEASAQFMNQAVGIIEAVLEKFGTYENFEAATGGQLLTKCQIWSTVRKYMQKEGCVGEIVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNSRQPWHSTEGRLQYGLQPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHQAAHMSFRQLFQDLAQYVQDEGVRWEYCVRAKRGQTDTSQPGCFSKDQVYLDGILRILRHRHTIDFQLLTSLGKVSYEDVEQLRPYGVLDNTRVPHFMKDLERYRQQLEHIMTTNRLDEAELGRLLPD", "length": 467 }, "evidence": [ { "id": "E1BJV3", "url": "https://omabrowser.org/oma/group/E1BJV3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tubulin-tyrosine carboxypeptidase", "id": "GO:0106423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106423", "evidence": [ { "database": "UniProtKB", "id": "E1BJV3", "url": "https://www.uniprot.org/uniprotkb/E1BJV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJV3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 471, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJV3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJV3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJV9-1", "uniprot_ac": "E1BJV9", "uniprot_id": "E1BJV9_BOVIN", "mass": { "chemical_mass": 80775.0, "monoisotopic_mass": 80775.0 }, "refseq": { "ac": "NP_001192973", "name": "actin filament-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192973" }, "gene_names": [ { "name": "AFAP1", "type": "recommended", "evidence": [ { "id": "E1BJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ] }, { "name": "AFAP1", "type": "synonym", "evidence": [ { "id": "NP_001192973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192973" } ] } ], "protein_names": [ { "name": "Actin filament-associated protein 1", "type": "recommended", "evidence": [ { "id": "E1BJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV9/entry#names_and_taxonomy" } ] }, { "name": "110 kDa actin filament-associated protein", "type": "synonym", "evidence": [ { "id": "E1BJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV9/entry#names_and_taxonomy" } ] }, { "name": "actin filament-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001192973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192973" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AFAP1", "url": "https://www.uniprot.org/uniprotkb/E1BJV9", "locus": { "chromosome": "6", "start_pos": 114134147, "end_pos": 114283820, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012464", "url": "https://www.ensembl.org/id/ENSBTAG00000012464" } ] } } ], "crossref": [ { "id": "E1BJV9", "url": "https://alphafold.ebi.ac.uk/entry/E1BJV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13306", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13306", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13307", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13307", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534032", "url": "https://www.ncbi.nlm.nih.gov/gene/534032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534032", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534032", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THMASIP", "url": "https://omabrowser.org/oma/group/THMASIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJV9", "url": "https://www.orthodb.org/?gene=E1BJV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14338:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14338:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192973", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6D6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVITDILLRIQSSRGFEVKDHATKPETPSSLPAPPQMPLPEIPQPWLPPDNGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVVREIYSGCSGPAELECPPPPSSPVHKVELEKKLSSERPSSDGEGVAENGIAMCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLILHKDRADLKTHIASIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEVSASVIQTAKQTFCFMNRRVLSTNPYVGSTSNGYAHPSGTALHYDDVPCISGSSKGKKPPVASNGVMGKGKALSGQQKKADSAAGVKRTPSNADQYKYGKNRVEADAKRLQAKEEELLRRREGLRDRLAQLRKERKGLRAAIEVNTGRKTQVVLEEKLKKLEEECKQKETERVNLELELTEVKESLKKALAGGITLGLAIEPRSGTSSPQSPVFRHRTLENSPMSSCETSDAEGPLPVNSAAVLKKSRPAPGNSPCRGHVLRKAKEWELKNGT", "length": 730, "header": "tr|E1BJV9-1|E1BJV9_BOVIN Isoform 1 of Actin filament-associated protein 1 OS=Bos taurus OX=9913 GN=AFAP1 PE=4 SV=3 CANONICAL=E1BJV9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6D6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV9/entry#A0AAA9S6D6-1", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVITDILLRIQSSRGFEVKDHATKPETPSSLPAPPQMPLPEIPQPWLPPDNGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVVREIYSGCSGPAELECPPPPSSPVHKVELEKKLSSERPSSDGEGVAENGIAMCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLILHKDRADLKTHIASIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEVSASVIQTAKQTFCFMNRRVLSTNPYVGSTSNGYAHPSGTALHYDDVPCISGSWGPDDDVPAPRNRGLGEEALYDNAVLYDNLPSPKIFARYPPADRKAARPSPDRLSCNHYKHPASSGLPSSPSVTNTSSVGRVSLGLSSQSKGKKPPVASNGVMGKGKALSGQQKKADSAAGVKRTPSNADQYKYGKNRVEADAKRLQAKEEELLRRREGLRDRLAQLRKERKGLRAAIEVNTGRKTQVVLEEKLKKLEEECKQKETERVNLELELTEVKESLKKALAGGITLGLAIEPRSGTSSPQSPVFRHRTLENSPMSSCETSDAEGPLPVNSAAVLKKSRPAPGNSPCRGHVLRKAKEWELKNGT", "length": 819, "header": "tr|A0AAA9S6D6-1|A0AAA9S6D6_BOVIN Computationally mapped isoform of Actin filament-associated protein 1 OS=Bos taurus OX=9913 GN=AFAP1 PE=4 SV=1 CANONICAL=E1BJV9-1" }, "locus": { "chromosome": "6", "start_pos": 114230873, "end_pos": 114139266, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098175.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098175.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079434.1" } ] } }, { "isoform_ac": "E1BJV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV9/entry#E1BJV9-1", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVITDILLRIQSSRGFEVKDHATKPETPSSLPAPPQMPLPEIPQPWLPPDNGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVVREIYSGCSGPAELECPPPPSSPVHKVELEKKLSSERPSSDGEGVAENGIAMCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLILHKDRADLKTHIASIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEVSASVIQTAKQTFCFMNRRVLSTNPYVGSTSNGYAHPSGTALHYDDVPCISGSSKGKKPPVASNGVMGKGKALSGQQKKADSAAGVKRTPSNADQYKYGKNRVEADAKRLQAKEEELLRRREGLRDRLAQLRKERKGLRAAIEVNTGRKTQVVLEEKLKKLEEECKQKETERVNLELELTEVKESLKKALAGGITLGLAIEPRSGTSSPQSPVFRHRTLENSPMSSCETSDAEGPLPVNSAAVLKKSRPAPGNSPCRGHVLRKAKEWELKNGT", "length": 730, "header": "tr|E1BJV9-1|E1BJV9_BOVIN Isoform 1 of Actin filament-associated protein 1 OS=Bos taurus OX=9913 GN=AFAP1 PE=4 SV=3 CANONICAL=E1BJV9-1" }, "locus": { "chromosome": "6", "start_pos": 114230873, "end_pos": 114139266, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016537.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016537.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016537.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016537.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534032", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534032", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GWC2-1", "protein_name": "Actin filament-associated protein 1", "gene_name": "Afap1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVLTNILLRIQSSSKGFEVKDHAQKAEANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCSITYIPRDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGSSGPVDPECSPPPSTSAPVNKAELEKKLSSERPSSDGEGAAENGVTCNGKEQVKRKKTSKSDAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDSKLIFHKDRSDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEMSANVIQTAKQTFCFMNRRAVSTSPYLGSISNGYAHPSGTALHYDDVPCVNGSLKSKKPPVSPNGVPGKGKAPSSQQKKVDSAGGVKRTASNADQYKYGKNRVEADAKLLQSREEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKTQVALEDKLKRLEEECKQREAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDAEGPLPVNSAAVLKKSQPSSGSSPCRGHVLQKAKEWELKNGT", "length": 731 }, "evidence": [ { "id": "E1BJV9", "url": "https://omabrowser.org/oma/group/E1BJV9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q80YS6-1", "protein_name": "Actin filament-associated protein 1", "gene_name": "Afap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVLTNILLRLQSSKGFEVKDHAQKAEANNLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCSITYIPRDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDPECSPPPSTSAPVNKAELEKKLSSERPSSDGEGGVENGVTTCNGKEQAKRKKPSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDSKLILHKDRADLKTHLVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEMSANVIQTAKQTFCFMNRRAVSTSPYLGSLSNGYAHPSGTALHYDDVPCVNGSLKNKKPPASSNGVPVKGKAPSSQQKKVETAGGVKRTASNAEQYKYGKNRVEADAKRLQSKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKTQAALEDKLKRLEEECKQREAERVSLELELTEVKESLKKALAGGVTLGLAIEPRSGTSSPQSPVFRHRTLENSPISSCDTSDAEGPLPVNSAAVLKKSQPSSGSSPCRGHVLQKAKEWELKNGT", "length": 731 }, "evidence": [ { "id": "E1BJV9", "url": "https://omabrowser.org/oma/group/E1BJV9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N556-1", "protein_name": "Actin filament-associated protein 1", "gene_name": "AFAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT", "length": 730 }, "evidence": [ { "id": "E1BJV9", "url": "https://omabrowser.org/oma/group/E1BJV9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VH46-1", "protein_name": "Actin filament-associated protein 1", "gene_name": "Afap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEELIVELRLFLELLDHEYLTSTVREKKAVLTNILLRMQSSKGFEVKDHAQKAETNNLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSEAMGSSYESYDEEEEDGKGKKTQHQCHHEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCSITYIPRDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDPECSPPPSASVPVNKAELEKKLSSERPSSDGEGVVENGVTTCNGKEQAKRKKPSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDSKLILHKDRADLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEMSANVIQTAKQTFCFMNRRAVSTSPYLGSLSNGYAHPSGTALHYDDVPCVNGSLKNKKPPASSNGLPVKGRAPSSQQKKVESAGGVKRTASNAEQYKYGKNRVEADAKRLQSKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKTQVALEDKLKRLEEECKQREAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDAEGPLPVNSAAVLKKSQPSSSSSPCRGHVLQKAREWELKNGT", "length": 731 }, "evidence": [ { "id": "E1BJV9", "url": "https://omabrowser.org/oma/group/E1BJV9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" }, { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "E1BJV9", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 730, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJV9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJV9" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 249, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 728, "end_pos": 730 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJX3-1", "uniprot_ac": "E1BJX3", "uniprot_id": "E1BJX3_BOVIN", "mass": { "chemical_mass": 124135.0, "monoisotopic_mass": 124135.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "RAD51 associated protein 2", "type": "synonym", "evidence": [ { "id": "E1BJX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJX3", "url": "https://www.uniprot.org/uniprotkb/E1BJX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BJX3", "locus": {} } ], "crossref": [ { "id": "E1BJX3", "url": "https://alphafold.ebi.ac.uk/entry/E1BJX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037812", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037812", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GGSHFPH", "url": "https://omabrowser.org/oma/group/GGSHFPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR39229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39229:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39229:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15696", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15696", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BJX3", "url": "https://www.uniprot.org/uniprotkb/E1BJX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLTQRAPQVSELGEPASPLPPADDPDSLPPRSKRPRLEETGGVSEVEWRLPLVPCLSEVEKVWELSLRPLTALMISTEEIFGNATGSCVKKSVSGKQIYNPEGQNSKFEMNSCLRSLPSQNFVSGVKTSRTSCEPGLYAREIFSVHCTDRFEIETGQLSHASVHDVHVIKNEDGQYLVQERDNSQEDNNDIKLTENPFLDITFYKDTKSTFHDIKNRCKAGSVMPSNKKENSVPASTLKIPKSQNQRGMEIAKPSYFRDKSTTSIPEFPTDLNSKMSSVYLKEIGKKNDKNEAYVRDFTNTHWSQNGPDVKKQKLQNDKKIVDAENIFSECYESNHQSVSNQSVCVRKKDLISLHYYNHSSIKFDAIDSAKNFTIKLENANCKETETCLYSYIFTRLEKLQSWDCNIIYILRKNRENSWTMDSYKVKYENMKKAGEILNLQQLLEIDLSKGNYHNMKVMKTHDEKAKPLMTETLGSQKALKQIFCLKDKGEKDNMLYFRHYTTQKDFHLSSYFESFITEIFYFHESISGNQKDNNILTWYGILKCKKQIDVQNLITETMNVSINNDISSICLQTNVLDPLNIILKTSITSLLNDFVSFTVVENDSKLEEGCIFKWIMYLNYPKNITLESHTVCSVRILTFSRLLDNNMKPKLKKRKLFKSEQIFEEPKKKLTNSFSMTSKNIHFPIFETYEKIPLLMDFDDIDEEKQKQKSFNFNYIFKDFFNTRQQAIQASHDKKHSEQTNPMTVTQVLGFGNLINEIEDKKYDLTLKEEGKITTQNLTNFCQGHEDIKTEKEEKNSFYSMDDMFIVQPVSLMTKLDVEETKYVNQSNVIDRNEYESTFQESELANSKHFHPKNDSSECFNHQFETHLSVGNNECFQDLTAKCLSTDVLTIANNFEMKSKFNLVLEELRMFHEISKENEILSTVETNNRQENYFVESNAVEEVKMEIKKGLKMGTENKLCSSSLLGDMIASPNMHKKHQSLFKWKTVPKNGEQEVPNDCCLRTPEEELLYSTSKEETMSDFYSLMYLYCLIFLGSSFSYGISRVLPLKTCGRPIRVGLSRKAKLKQLHPYLK", "length": 1074, "header": "tr|E1BJX3-1|E1BJX3_BOVIN Isoform 1 of RAD51 associated protein 2 OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BJX3-1" }, "isoforms": [ { "isoform_ac": "E1BJX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX3/entry#E1BJX3-1", "sequence": { "sequence": "MSLTQRAPQVSELGEPASPLPPADDPDSLPPRSKRPRLEETGGVSEVEWRLPLVPCLSEVEKVWELSLRPLTALMISTEEIFGNATGSCVKKSVSGKQIYNPEGQNSKFEMNSCLRSLPSQNFVSGVKTSRTSCEPGLYAREIFSVHCTDRFEIETGQLSHASVHDVHVIKNEDGQYLVQERDNSQEDNNDIKLTENPFLDITFYKDTKSTFHDIKNRCKAGSVMPSNKKENSVPASTLKIPKSQNQRGMEIAKPSYFRDKSTTSIPEFPTDLNSKMSSVYLKEIGKKNDKNEAYVRDFTNTHWSQNGPDVKKQKLQNDKKIVDAENIFSECYESNHQSVSNQSVCVRKKDLISLHYYNHSSIKFDAIDSAKNFTIKLENANCKETETCLYSYIFTRLEKLQSWDCNIIYILRKNRENSWTMDSYKVKYENMKKAGEILNLQQLLEIDLSKGNYHNMKVMKTHDEKAKPLMTETLGSQKALKQIFCLKDKGEKDNMLYFRHYTTQKDFHLSSYFESFITEIFYFHESISGNQKDNNILTWYGILKCKKQIDVQNLITETMNVSINNDISSICLQTNVLDPLNIILKTSITSLLNDFVSFTVVENDSKLEEGCIFKWIMYLNYPKNITLESHTVCSVRILTFSRLLDNNMKPKLKKRKLFKSEQIFEEPKKKLTNSFSMTSKNIHFPIFETYEKIPLLMDFDDIDEEKQKQKSFNFNYIFKDFFNTRQQAIQASHDKKHSEQTNPMTVTQVLGFGNLINEIEDKKYDLTLKEEGKITTQNLTNFCQGHEDIKTEKEEKNSFYSMDDMFIVQPVSLMTKLDVEETKYVNQSNVIDRNEYESTFQESELANSKHFHPKNDSSECFNHQFETHLSVGNNECFQDLTAKCLSTDVLTIANNFEMKSKFNLVLEELRMFHEISKENEILSTVETNNRQENYFVESNAVEEVKMEIKKGLKMGTENKLCSSSLLGDMIASPNMHKKHQSLFKWKTVPKNGEQEVPNDCCLRTPEEELLYSTSKEETMSDFYSLMYLYCLIFLGSSFSYGISRVLPLKTCGRPIRVGLSRKAKLKQLHPYLK", "length": 1074, "header": "tr|E1BJX3-1|E1BJX3_BOVIN Isoform 1 of RAD51 associated protein 2 OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=E1BJX3-1" }, "locus": { "chromosome": "11", "start_pos": 81097690, "end_pos": 81091299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000055123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047693.2", "url": "https://www.ensembl.org/id/ENSBTAP00000047693.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3UW63-1", "protein_name": "RAD51 associated protein 2", "gene_name": "Rad51ap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLSRPAWPAGPAWPVSSEPPPEDPAAASPSSKRRRLKEPDGGVSEAGWPLLVVPRLSEVEKVWEWSLRPFTAFLIPKSPGSSAGGKQSCDLGCRDRTFQAHSCWQSGILGCSRAPRRSCEAGLQDREVQGVRLGDQAEVSHAPPNSPMPYVQGVKQEPEELPEKETILKEKNSVREPGNPFLDVPFSEETKSALHEIKDRCKVDSVITSEKKENVSSSTLKISKFQNQACLESAKPSYFRDSNTKNFFEFPRDLNSNMSFVYLKETAKKKNDKIVAYVRDFTNIFSSQNRPNAKKQKLQDDKKNVYVENDFSDYSESYHQSLTIEGKIDLINLNYYRHSSIECDVRDSKKNFTLTLEVANCEGTERNQEYYIPTRQEFQNLDCDRSILKIKKENCWRIKKIRIICENNMILENNIVSLHDNFDSFIRKKEKKKDDRESEEGCIFKYIVNLNYLKNIKKERYIVYLTKMLTSLRLLECNTKSTAKKRKLFKTEHVLQRVKKQNINSLTMTTKIFLIYKLCENVPPLMGFDNTEELSLTKESSYESTRCAKLLLNMKNLDYYSFGIDGTHVESDPLFIQNNCGHINEKYYESSMYNQDLDTVRKWKHKTIHFIFKSIFEDVFNVRQLCTLLSQNTSHSDQINAMAITLKISLENLLSETEGKIYDFVLKREMKVTKSSSSFQAHNAIDTEKEEDSFPTMDGMSSVQSASLVSKSINMEETKSLNQNNRTSTKEDGGILQESELANSKHFHPKNESALYANHQFESDSSGENNECFQGLTATCLSTETLPIAEEFEMKSKFDLVLEELRMFHEISKENEIPSTRMTNNRKENYFGESNDVKEARMEIGKKLEMVETNTRNAPFLSCDVKAGLNKHKRHQSLFNWKMLPTHGGQAVPNECWPRSEERSLHSTPEEDYKKHLPKSPTFSPDEYKNETLLKGGSHFSHGISRVQPLKTCSRPIRVGLSRRARLKQLHPYLK", "length": 976 }, "evidence": [ { "id": "E1BJX3", "url": "https://omabrowser.org/oma/group/E1BJX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0R7M4-1", "protein_name": "RAD51 associated protein 2", "gene_name": "Rad51ap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSRPAWPSGPAWPLSSEPPPQDPAAASPSSKRRRLKEPDGVCEAGWPLLVVPRLSEVEKVWEWSPRPFTAFLIPKSPGSSGGGRQRCDPGCGDTTFQTQNCWQSGISGRAVCSRAPGRSCEAGLKDGEGVYLGDQAEVSHAPPNTLMPHVQGVKQESEELPEKETILKEKNSVARQPRNPFLDVTFSEETKSALHEIKDRCKVDSVITSEKRENVSSSTLKIPKIQNQACLESAKPSYFRDSITKNFPEFPRDLNSNMSFVYLKEVAKKKNDKIVAYVRDFTNIFLSQNRPDAKKQKLQDKKYVHVENDFSDYSESNHQSLTIEGKIDLINLNYYRHGSIECDVRDSKKNITLTLENANLEGAERNQDYYIPTRQKESQSPNYNKSILKRKQQNWRMKKFRIIYENMNKHGEHLNLALCGDLLHKADYHSVKVRNVMIGTLGSPPNLIKVVWFNGKGENINMLQLRYYTLQKYISGNKEDSTLICHEMSTCEKQIDTQKSGVLSKYLQNSISEFLNMILKTNTVSLLDNFDSFIRNAGDGESEEGCIFKYIVNLNYLKNIIQERHIVYLTKMLTSSRLLEHNTKSTVKKRKLFKMEHVLEWAKKQNINSLTMTTKKFPVYKVCENVPLLMNFDSTEELSLTKQPSYENTNCAEQLLNMGDLAYYMFGISNSHVKSDLLFIQNNCGHINEKYYESSMCSQDLDTERKWKHKAIHLIFKFIFEDVFNVRQLCMLLSQNTSHSDQINAMAITLKINLEDLLSKIEGKIYDFVLKKEMKVTKSSSSCQVHKAIDTKKQESSFLPMDRMSSVQSASLVSKSINMEETKSVNQNNGTSAKEDGGILQEIELTNSKHFHPENESALYANHQFESDSSGENNECFQGLTAKCLSTETLPIANEFEIKSKFDLVLEELRMFHEISKENEIPSTMETHNREENYFGESNDVKEARMEIGNKLEMVETSTRDTSLLPCDVKAGLNKHKRHQSLFNWKVIPTHGGQAVPNESCPGSEEELFHSTPEEDYKKPLPKSSTFSPDEYKKETLLKGGSHVSHGISRVQPLKTCSRPIRVGLSRRARLKQLHPYLK", "length": 1081 }, "evidence": [ { "id": "E1BJX3", "url": "https://omabrowser.org/oma/group/E1BJX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q09MP3-1", "protein_name": "RAD51-associated protein 2", "gene_name": "RAD51AP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLPQPTPRMAELRKPTSSLTPPEDPDSQPPSSKRLCLEEPGGVFKAGWRLPLVPRLSEAEKVWELSPRPFKGLLVSTNAIFDNSTDSCVEKSVSGKQICNLKCSNLKFQMSSCLQSPPSQSPDSDLRASGRSEAGLHDREAFSVHRSNSSKAGVSQLLPSTSIHDIHGIRNENRKQQFVQGRDNVHKENPFLDVTFYKETKSPFHEIKNRCKANSVVPSNKRENNISSSVLKISKSQNQPSLEIAKPSYFRDSGTISVPQFPMDLNSKMSSVYLKEIAKKKNDKKEAYVRDFTNIYWSQNRPDVKKQKLQNDKKTVEAENIFSKCYENDYPSLSSQNTCKRKDLISSNYCNCSSIQCNVRDSRKNFAILENANWEEAECLDSYVLTRLEKSQNWDCNVRHILRRNRGNCWIINNCKTKCENMKKTEEKWNWLLLLEIDLLSKEDYHCAKVINAYEEQSKLLVREILGSQTALITTVWLNGKGENDNTLQLRYNTTQKVFHVNNPFESFIIEIFYFHKSISGNKKDNSILTCCNILKCKKQIGIIGIQNLITRNMNTNIKNGILSIYLQDSVSEPLDILLKTNIAFLLNNFDSLTRIENDFELEEECIFKCMLYLKYPKNIVENHTAYLVKILTSSRLLEDNMKPMLKKRKLFRTEQVFEKSKKKLINSFSMTTQNTGFPIFETYEKIPLLMDFDDMDEISLIREITCQNMSCPQQVVNVENWAHYNSSTVKAHGNSCPQFIQNNRGYINENFYEVNMHSQDLNMERKQGHNKISNFDCEHIFEDLCNVRQQAIPASHNIIHNEETHTTSITQVLNFWNLLSEIEEKKYDLILKEEVKVTAESLTNSCQVHKDTKIEKEEKDSFFPMDDMFSVQSVSLISKEVNVEENKYVNQNYVTNTNEYESILPEREIANSKDFHRKNDSALYINHQFETGLSEGNDECFQDLAAKYLSTEALTIVKDFEMKRKFDLVLEELRMFHEISRENELLSTVETNNGQENYFGENDAEKVKMEIEKDLKMVVVNKIRASSSFHDTIAGPNMGKSHQSLFKWKTVPNNGEQEVPNESCYPSRSEEELLYSTSEKDCETPLPKRPAFLPDECKEEFNYLLRGGSHFPHGISRVRPLKTCSRPIRIGLSRKARIKQLHPYLKQMCYGNLKENF", "length": 1159 }, "evidence": [ { "id": "E1BJX3", "url": "https://omabrowser.org/oma/group/E1BJX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BJX3", "url": "https://www.uniprot.org/uniprotkb/E1BJX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 779, "end_pos": 781, "annotation": "n_glycosylation_sequon" }, { "start_pos": 827, "end_pos": 829, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1074, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJX3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX3" }, { "id": "PF15696", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15696" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAD51 interacting motif", "eco_id": "ECO_0000259", "start_pos": 1036, "end_pos": 1073, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 342, "end_pos": 344 }, { "start_pos": 359, "end_pos": 361 }, { "start_pos": 373, "end_pos": 375 }, { "start_pos": 561, "end_pos": 563 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 779, "end_pos": 781 }, { "start_pos": 827, "end_pos": 829 }, { "start_pos": 84, "end_pos": 86 }, { "start_pos": 856, "end_pos": 858 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJY7-1", "uniprot_ac": "E1BJY7", "uniprot_id": "E1BJY7_BOVIN", "mass": { "chemical_mass": 39455.0, "monoisotopic_mass": 39455.0 }, "refseq": { "ac": "XP_059739369", "name": "uncharacterized protein CXorf58 homolog isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739369" }, "gene_names": [ { "name": "CXHXorf58", "type": "recommended", "evidence": [ { "id": "E1BJY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJY7" } ] }, { "name": "CXHXorf58", "type": "synonym", "evidence": [ { "id": "XP_059739369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739369" } ] } ], "protein_names": [ { "name": "Chromosome X CXorf58 homolog", "type": "synonym", "evidence": [ { "id": "E1BJY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJY7/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein CXorf58 homolog isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739369" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJY7", "url": "https://www.uniprot.org/uniprotkb/E1BJY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CXHXorf58", "url": "https://www.uniprot.org/uniprotkb/E1BJY7", "locus": { "chromosome": "X", "start_pos": 119315053, "end_pos": 119337768, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010939", "url": "https://www.ensembl.org/id/ENSBTAG00000010939" } ] } } ], "crossref": [ { "id": "E1BJY7", "url": "https://alphafold.ebi.ac.uk/entry/E1BJY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515411", "url": "https://www.ncbi.nlm.nih.gov/gene/515411", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BJY7", "url": "https://www.orthodb.org/?gene=E1BJY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33504", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33504", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33504:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33504:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059739369", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739369", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BJY7", "url": "https://www.uniprot.org/uniprotkb/E1BJY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHSLKVPVTGVPKSDNPHLGKGHKVHLSNTVKTKEKQQNKDVSAHIIQKAWLSHLDKTVFQLLKHTICAAEHHVTHEILKKVSPLEAELAKDPCMKCKVRFRFSGEIFPPFIVFKIFLHTEGHGYKYFSGKKFLKPSSEAEADAYKIMGRKKFYHQIKEDERLFQKFKITDDIDVVTLKDYMQYSSHLDEIPASSGGRNNCWRRLSLENIPRTMIMYDIVDYAESGIISKRLKKEMKYLLQRPKTEEMRQHQLRIVSEVRSPLSLSSLQPLYRPYQQQSQIRHLGRRSKQALMKVEKMKRAYKMAKEKNASVGNQKWTYQVQSRKRQLSSPPHLLTL", "length": 338, "header": "tr|E1BJY7-1|E1BJY7_BOVIN Isoform 1 of Chromosome X CXorf58 homolog OS=Bos taurus OX=9913 GN=CXHXorf58 PE=4 SV=5 CANONICAL=E1BJY7-1" }, "isoforms": [ { "isoform_ac": "E1BJY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BJY7/entry#E1BJY7-1", "sequence": { "sequence": "MSHSLKVPVTGVPKSDNPHLGKGHKVHLSNTVKTKEKQQNKDVSAHIIQKAWLSHLDKTVFQLLKHTICAAEHHVTHEILKKVSPLEAELAKDPCMKCKVRFRFSGEIFPPFIVFKIFLHTEGHGYKYFSGKKFLKPSSEAEADAYKIMGRKKFYHQIKEDERLFQKFKITDDIDVVTLKDYMQYSSHLDEIPASSGGRNNCWRRLSLENIPRTMIMYDIVDYAESGIISKRLKKEMKYLLQRPKTEEMRQHQLRIVSEVRSPLSLSSLQPLYRPYQQQSQIRHLGRRSKQALMKVEKMKRAYKMAKEKNASVGNQKWTYQVQSRKRQLSSPPHLLTL", "length": 338, "header": "tr|E1BJY7-1|E1BJY7_BOVIN Isoform 1 of Chromosome X CXorf58 homolog OS=Bos taurus OX=9913 GN=CXHXorf58 PE=4 SV=5 CANONICAL=E1BJY7-1" }, "locus": { "chromosome": "X", "start_pos": 119335213, "end_pos": 119315413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044384.6", "url": "https://www.ensembl.org/id/ENSBTAT00000044384.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041886.6", "url": "https://www.ensembl.org/id/ENSBTAP00000041886.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 338, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJY7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 310, "end_pos": 312 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJZ1-1", "uniprot_ac": "E1BJZ1", "uniprot_id": "E1BJZ1_BOVIN", "mass": { "chemical_mass": 84707.0, "monoisotopic_mass": 84707.0 }, "refseq": { "ac": "NP_001192937", "name": "fibronectin type III and SPRY domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192937" }, "gene_names": [ { "name": "FSD2", "type": "recommended", "evidence": [ { "id": "E1BJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1" } ] }, { "name": "FSD2", "type": "synonym", "evidence": [ { "id": "NP_001192937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192937" } ] } ], "protein_names": [ { "name": "Fibronectin type III and SPRY domain containing 2", "type": "synonym", "evidence": [ { "id": "E1BJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1/entry#names_and_taxonomy" } ] }, { "name": "fibronectin type III and SPRY domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001192937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192937" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJZ1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSD2", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1", "locus": { "chromosome": "21", "start_pos": 23037004, "end_pos": 23059943, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015018", "url": "https://www.ensembl.org/id/ENSBTAG00000015018" } ] } } ], "crossref": [ { "id": "E1BJZ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BJZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015018", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015018", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540530", "url": "https://www.ncbi.nlm.nih.gov/gene/540530", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540530", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540530", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GIPNCEV", "url": "https://omabrowser.org/oma/group/GIPNCEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJZ1", "url": "https://www.orthodb.org/?gene=E1BJZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192937", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TW41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJZ1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEGAGEAPGLGRSAASKDFRFYHMDLYDSQDRLQIFPEESTRMRREGVQAEMTHEPMRGGVKVKAPRDLGEEVDELVHLYGLEDDHELGDEFIEENTPRIEVSEYPSYMMMGSEQRDWRPTGEAAQGEDLGFMGWGSAGQCQDLREAYRYSHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRASEKDQDEHKQHEVTPLSKALESAKDEIHKNMYKLEKQIIEMENFASHLEEVFITVEENFGRQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVNCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDEEISAQPDFEDQTLDFSDVEELMGSINTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDGSPGKEQTEVTMTIKETYCSVTNLLPNTQYEFWVTAQNRAGLSPTSERAVYMTAPCPPIIKSKEIRSCEEAALISWESGNLNPVDSYTVELTQAETPGASGVTESVVGIPTCECLVQLQPRQNYTIYVRALNVGGPSARSEPATVHTTGSYFSLDEHTCHPRLTVSEDGLTVVRSERRGPAKEPVPSDAQFTRCAAVMGNLIPVRGRHYWEVEVDECLDYTVGVAFEDVPRQEDLGANRLSWCMRHAFASSRHKYEFLHNKMTPDIRITVPPKKIGILLDYENAKLSFFNVDISQHLYTFSCQLHQFVHPCFSLEKPGCLKIYNGISMPKHVTFY", "length": 748, "header": "tr|E1BJZ1-1|E1BJZ1_BOVIN Isoform 1 of Fibronectin type III and SPRY domain containing 2 OS=Bos taurus OX=9913 GN=FSD2 PE=4 SV=3 CANONICAL=E1BJZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TW41-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1/entry#A0AAA9TW41-1", "sequence": { "sequence": "MEEGAGEAPGLGRSAASKDFRFYHMDLYDSQDRLQIFPEESTRMRREGVQAEMTHEPMRGGVKVKAPRDLGEEVDELVHLYGLEDDHELGDEFIEENTPRIEVSEYPSYMMMGSEQRDWRPTGEAAQGEDLGFMGWGSAGQCQDLREAYRYSHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRASEKDQDEHKQHEVTPLSKALESAKDEIHKNMYKLEKQIIEMENFASHLEEVFITVEENFGRQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVNCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDEEISAQPDFEDQTLDFSDVEELMGSINTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDGSPGKEQTAPCPPIIKSKEIRSCEEAALISWESGNLNPVDSYTVELTQAETPGASGVTESVVGIPTCECLVQLQPRQNYTIYVRALNVGGPSARSEPATVHTTGSYFSLDEHTCHPRLTVSEDGLTVVRSERRGPAKEPVPSDAQFTRCAAVMGNLIPVRGRHYWEVEVDECLDYTVGVAFEDVPRQEDLGANRLSWCMRHAFASSRHKYEFLHNKMTPDIRITVPPKKIGILLDYENAKLSFFNVDISQHLYTFSCQLHQFVHPCFSLEKPGCLKIYNGISMPKHVTFY", "length": 703, "header": "tr|A0AAA9TW41-1|A0AAA9TW41_BOVIN Computationally mapped isoform of Fibronectin type III and SPRY domain containing 2 OS=Bos taurus OX=9913 GN=FSD2 PE=4 SV=1 CANONICAL=E1BJZ1-1" }, "locus": { "chromosome": "21", "start_pos": 23059744, "end_pos": 23037687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110750.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110750.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100828.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100828.1" } ] } }, { "isoform_ac": "E1BJZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1/entry#E1BJZ1-1", "sequence": { "sequence": "MEEGAGEAPGLGRSAASKDFRFYHMDLYDSQDRLQIFPEESTRMRREGVQAEMTHEPMRGGVKVKAPRDLGEEVDELVHLYGLEDDHELGDEFIEENTPRIEVSEYPSYMMMGSEQRDWRPTGEAAQGEDLGFMGWGSAGQCQDLREAYRYSHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRASEKDQDEHKQHEVTPLSKALESAKDEIHKNMYKLEKQIIEMENFASHLEEVFITVEENFGRQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVNCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDEEISAQPDFEDQTLDFSDVEELMGSINTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDGSPGKEQTEVTMTIKETYCSVTNLLPNTQYEFWVTAQNRAGLSPTSERAVYMTAPCPPIIKSKEIRSCEEAALISWESGNLNPVDSYTVELTQAETPGASGVTESVVGIPTCECLVQLQPRQNYTIYVRALNVGGPSARSEPATVHTTGSYFSLDEHTCHPRLTVSEDGLTVVRSERRGPAKEPVPSDAQFTRCAAVMGNLIPVRGRHYWEVEVDECLDYTVGVAFEDVPRQEDLGANRLSWCMRHAFASSRHKYEFLHNKMTPDIRITVPPKKIGILLDYENAKLSFFNVDISQHLYTFSCQLHQFVHPCFSLEKPGCLKIYNGISMPKHVTFY", "length": 748, "header": "tr|E1BJZ1-1|E1BJZ1_BOVIN Isoform 1 of Fibronectin type III and SPRY domain containing 2 OS=Bos taurus OX=9913 GN=FSD2 PE=4 SV=3 CANONICAL=E1BJZ1-1" }, "locus": { "chromosome": "21", "start_pos": 23059744, "end_pos": 23037687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019994.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019994.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019994.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019994.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540530", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540530", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L4K1-1", "protein_name": "Fibronectin type III and SPRY domain-containing protein 2", "gene_name": "FSD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY", "length": 749 }, "evidence": [ { "id": "E1BJZ1", "url": "https://omabrowser.org/oma/group/E1BJZ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D4ADN6-1", "protein_name": "Fibronectin type III and SPRY domain containing 2", "gene_name": "Fsd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEEAGEEPGLGRSTAPRDFHFYHMDLYDSEDRLQLFPGESSRTRREVTQAELTNEPRGAGDSKNLQKEVDALVHLYGLEDEHELGGEFVDEHRLGTLGYPYGMRRRDPGREQRDWGLSGEAAEAEDLCYGVQGPPDQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEPADVFCVTCKTPVRTVEKDFDIHKEHEVTPINKALEHAKDEIHKNMCKLEQQIIEMENFASHLEEVFITVEENFGRQEQNFECHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDACRELMETIEEMCHEEKVDFLKDAVAMTDRLGKFLKTKTDVELSAKPEFEDQTLDFSDVEQLMDSINTVPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGKDQAEFTMTVKETYCSVKNLEPNTQYEFWVIAQNRTGPSPSSEHVVYMTAPSPPSIKTEAIRSCEEAVLICWESGNLNPVDSYTVELIQAETPEASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVGGTSARSKPATVHTTGSYFQLNKDTCHPWLTISEDGFTVVRSEKKRSFRRELPPSKAQFSRCVAVMGNLIPVRGRHYWEVEVDEHLDYTVGVACEDVPKQEDLGANRLSWCMRHTFASTRHRYEFLHNGTTPDIRITVAPKKIGVLLDYEDSKLSFFNVDIAQHLYTFSCPLHQFVHPCFSLEKSGGLKICNGISAPKHVTFF", "length": 746 }, "evidence": [ { "id": "E1BJZ1", "url": "https://omabrowser.org/oma/group/E1BJZ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RI98-1", "protein_name": "Fibronectin type III and SPRY domain-containing protein 2", "gene_name": "FSD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEEAGEAPGLGRPAAPKDFHFYHVDLYDSEDRLQIFPEGNARMRREVVQAEMTNEPRAAVKGKAPRDLEEEVDELVHLYGLEDDHELGDAFVDESMPRIEVSEYPPYGMTGREAAREQRDWRLSGEEANAEDLGLGGWGSADQCQDLREAYRYTHGRASEEYECYVIPEEEDEDEAADVFCVTCKTPVRALEVSDEHKEHEVTPLHKALESAKDEIHKNMYKLEKQIIEMENFASHLEEVFITVEENFGRQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISTQPDFDDQTLDFSDVEQLMDSLNTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVRDSSPEKDQAEFTMTIKETYCSVTNLVPNTQYEFWVTARNRAGLSPASERAVYMTAPSPPTIKSREIRSCEEAALICWESGNLNPVDSYTVELSQAEAPGASGVTESVVGIPTCECLVQLQPRQSYIIYVRALNVGGPSARSQPATVHTTGSYFHLNEHTCHPWLTISEDGLTVVRSERRAPASELLSSDTRFTRCVAVMGNLIPVRGRHYWEVEVDECLDYTVGVAFEDVPKQEDLGANHLSWCMRHTFASSRHKYEFLHNKTTPDIRITVSPKKIGILLDYENSKLSFFNVGLSQHLYTFSCQLHQFVHPCFSLEKPGCLKIHNGISMPKHVTFY", "length": 750 }, "evidence": [ { "id": "E1BJZ1", "url": "https://omabrowser.org/oma/group/E1BJZ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BZ52-1", "protein_name": "Fibronectin type III and SPRY domain-containing protein 2", "gene_name": "Fsd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEEAEEESGLGRSAAPKDFHFYHMDLYDSEDRLQLFPGDSSRIRREVTQAEDDRELGDEFVDEHRLGTLGYPSYGMRRRDPGREPRDWGEAAEAEDLGYGGGQGPLDQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEPADVFCITCKTPVRTVEKDFDTHKEHEVTPISKALEHAKDEVHKNMCKLEQQIIEMENFASHLEEVFITVEENFGRQEQNFECHYNGILETLAQKYEEKIQALGEKKREKLEALYGQLVSCGENLDACRELMETVEEMCHEEKVEFLKDAVAMTDRLGKFLKTKTDVELSAQPEFEDQTLDFSDVEQLMDAINTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSSGKDRAEFTMMVKETYCSVTNLEPNTQYEFWVIAQNRTGPSPCSEHAVYMTAPSPPSIKTEAIRSCEEAVLICWESGNLNPVDSYTVELIQAETPEASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVGGTSARSEPATVHTTGSYFQLNKDTCHPWLTISEDGFTVVRSEKKSFRKELPPSKTQFTRCVAVMGNLIPVRGRHYWEVEVAEHLDYTVGVACEDVPKQEDLGANSLSWCMRHTFVSKRHRYEFLHNKMTPDIRITVAPRKIGVLLDYENAKLSFFNVDIAQHLYTFSCQLHQFVHPCFSLEKSGCLKICNGISMPKHVTFF", "length": 716 }, "evidence": [ { "id": "E1BJZ1", "url": "https://omabrowser.org/oma/group/E1BJZ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 748, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJZ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 545, "end_pos": 743, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ1" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 374, "end_pos": 469, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 536, "end_pos": 538 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BJZ4-1", "uniprot_ac": "E1BJZ4", "uniprot_id": "E1BJZ4_BOVIN", "mass": { "chemical_mass": 96045.0, "monoisotopic_mass": 96045.0 }, "refseq": {}, "gene_names": [ { "name": "GCC1", "type": "recommended", "evidence": [ { "id": "E1BJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" } ] } ], "protein_names": [ { "name": "GRIP and coiled-coil domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4/entry#names_and_taxonomy" } ] }, { "name": "Golgi coiled-coil protein 1", "type": "synonym", "evidence": [ { "id": "E1BJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probably involved in maintaining Golgi structure.", "evidence": [ { "database": "UniProtKB", "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4#function" }, { "database": "UniProtKB", "id": "ARBA00055375", "url": "https://www.uniprot.org/uniprotkb/ARBA00055375#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCC1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4", "locus": { "chromosome": "4", "start_pos": 91810880, "end_pos": 91815478, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003102", "url": "https://www.ensembl.org/id/ENSBTAG00000003102" } ] } } ], "crossref": [ { "id": "E1BJZ4", "url": "https://alphafold.ebi.ac.uk/entry/E1BJZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003102", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003102", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJZ4", "url": "https://www.orthodb.org/?gene=E1BJZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23157:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23157:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKFGMNFGGGPSKKDLLEIIETQKKQLLQYQTRLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQPQGLTFPDSVDDRCSTHSEDSTGTAASLDTAASLTSTKGEFGIEDDRLARGPPPLKLEEASGSESGVSCSSGDGPSGGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASKKAEEERGRLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERAQRQDLELRLEETREALAGRAYAAGQMEGFELQTKQLTREVEELKGELQALRDEKNQPDPRLKELQEEAACLKSHFQAQLQQEMRKVIIFISFKCESFNLKWLLRWLIGKESTCQWKRFWRYGFDPWVRKIPWSRKLQPTPVFLPGKPYRQRSLTAVAEDQLRQQSQLEEQRVVALENQISQVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNVKDGNLGKELEEAREQLAELKEKYISLRLSCEELERQHQQEAEGWKQELARLQHGHRQELERSQLDFRDRTLKLEEELHKQRDRALAVLAEKDLELEQLRSVALSSGLPGRRSPVGGAGPRDQADTSPPDSLTQALQLAAVSEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHRLRDRLLEEGERHREEVGALQSHIAKHSRDQSREGANLEYLKNIIYRFLTLPDTLGRQQTLTAILTILHFSPEEKQAIMRLPVGGGWWPSGKR", "length": 843, "header": "tr|E1BJZ4-1|E1BJZ4_BOVIN Isoform 1 of GRIP and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=GCC1 PE=4 SV=2 CANONICAL=E1BJZ4-1" }, "isoforms": [ { "isoform_ac": "E1BJZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4/entry#E1BJZ4-1", "sequence": { "sequence": "MEKFGMNFGGGPSKKDLLEIIETQKKQLLQYQTRLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQPQGLTFPDSVDDRCSTHSEDSTGTAASLDTAASLTSTKGEFGIEDDRLARGPPPLKLEEASGSESGVSCSSGDGPSGGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASKKAEEERGRLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERAQRQDLELRLEETREALAGRAYAAGQMEGFELQTKQLTREVEELKGELQALRDEKNQPDPRLKELQEEAACLKSHFQAQLQQEMRKVIIFISFKCESFNLKWLLRWLIGKESTCQWKRFWRYGFDPWVRKIPWSRKLQPTPVFLPGKPYRQRSLTAVAEDQLRQQSQLEEQRVVALENQISQVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNVKDGNLGKELEEAREQLAELKEKYISLRLSCEELERQHQQEAEGWKQELARLQHGHRQELERSQLDFRDRTLKLEEELHKQRDRALAVLAEKDLELEQLRSVALSSGLPGRRSPVGGAGPRDQADTSPPDSLTQALQLAAVSEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHRLRDRLLEEGERHREEVGALQSHIAKHSRDQSREGANLEYLKNIIYRFLTLPDTLGRQQTLTAILTILHFSPEEKQAIMRLPVGGGWWPSGKR", "length": 843, "header": "tr|E1BJZ4-1|E1BJZ4_BOVIN Isoform 1 of GRIP and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=GCC1 PE=4 SV=2 CANONICAL=E1BJZ4-1" }, "locus": { "chromosome": "4", "start_pos": 91815279, "end_pos": 91811884, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004036.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004036.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004036.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004036.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BJZ4", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BJZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 843, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BJZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BJZ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJZ4" }, { "id": "PS50913", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50913" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GRIP", "eco_id": "ECO_0000259", "start_pos": 781, "end_pos": 831, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 473, "end_pos": 475 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK21-1", "uniprot_ac": "E1BK21", "uniprot_id": "E1BK21_BOVIN", "mass": { "chemical_mass": 19806.0, "monoisotopic_mass": 19806.0 }, "refseq": { "ac": "XP_005215047", "name": "uncharacterized protein C20orf144 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215047" }, "gene_names": [ { "name": "C13H20orf144", "type": "recommended", "evidence": [ { "id": "E1BK21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK21" } ] }, { "name": "C13H20orf144", "type": "synonym", "evidence": [ { "id": "XP_005215047", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215047" } ] } ], "protein_names": [ { "name": "Chromosome 13 C20orf144 homolog", "type": "synonym", "evidence": [ { "id": "E1BK21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK21/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C20orf144 homolog", "type": "synonym", "evidence": [ { "id": "XP_005215047", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215047" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK21", "url": "https://www.uniprot.org/uniprotkb/E1BK21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C13H20orf144", "url": "https://www.uniprot.org/uniprotkb/E1BK21", "locus": { "chromosome": "13", "start_pos": 63117085, "end_pos": 63115545, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003962", "url": "https://www.ensembl.org/id/ENSBTAG00000003962" } ] } } ], "crossref": [ { "id": "E1BK21", "url": "https://alphafold.ebi.ac.uk/entry/E1BK21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101902259", "url": "https://www.ncbi.nlm.nih.gov/gene/101902259", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101902259", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902259", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR37335", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37335", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37335:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37335:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215047", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215047", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BK21", "url": "https://www.uniprot.org/uniprotkb/E1BK21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK21-1", "url": "https://www.uniprot.org/uniprotkb/E1BK21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNNSSHKRTKVPKQARKEKPPDMDKARRKRQFFNHLKWKKPSTKIVLLFPLDKRQQLAEATAGPGARPERASEAAADTPTGPPATAPMLRGAGDGAERRESARAREMKKILVLLLLLDARLQEEGRRAAGGPGGGAKAAQGWQRLYTRLLTESETDCEAEAAEEQPRKRRRCPRPRP", "length": 178, "header": "tr|E1BK21-1|E1BK21_BOVIN Isoform 1 of Chromosome 13 C20orf144 homolog OS=Bos taurus OX=9913 GN=C13H20orf144 PE=4 SV=3 CANONICAL=E1BK21-1" }, "isoforms": [ { "isoform_ac": "E1BK21-1", "url": "https://www.uniprot.org/uniprotkb/E1BK21/entry#E1BK21-1", "sequence": { "sequence": "MGNNSSHKRTKVPKQARKEKPPDMDKARRKRQFFNHLKWKKPSTKIVLLFPLDKRQQLAEATAGPGARPERASEAAADTPTGPPATAPMLRGAGDGAERRESARAREMKKILVLLLLLDARLQEEGRRAAGGPGGGAKAAQGWQRLYTRLLTESETDCEAEAAEEQPRKRRRCPRPRP", "length": 178, "header": "tr|E1BK21-1|E1BK21_BOVIN Isoform 1 of Chromosome 13 C20orf144 homolog OS=Bos taurus OX=9913 GN=C13H20orf144 PE=4 SV=3 CANONICAL=E1BK21-1" }, "locus": { "chromosome": "13", "start_pos": 63117029, "end_pos": 63115589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044352.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044352.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041857.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041857.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101902259", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902259", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK21" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK28-1", "uniprot_ac": "E1BK28", "uniprot_id": "E1BK28_BOVIN", "mass": { "chemical_mass": 132894.0, "monoisotopic_mass": 132894.0 }, "refseq": { "ac": "NP_001073066", "name": "dynein axonemal assembly factor 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066" }, "gene_names": [ { "name": "DNAAF9", "type": "recommended", "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" } ] }, { "name": "C13H20orf194", "type": "synonym", "evidence": [ { "id": "NP_001073066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066" } ] }, { "name": "DNAAF9", "type": "synonym", "evidence": [ { "id": "NP_001073066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066" } ] } ], "protein_names": [ { "name": "Dynein axonemal assembly factor 9", "type": "synonym", "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28/entry#names_and_taxonomy" } ] }, { "name": "chromosome 13 C20orf194 homolog", "type": "synonym", "evidence": [ { "id": "NP_001073066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066" } ] }, { "name": "dynein axonemal assembly factor 9", "type": "synonym", "evidence": [ { "id": "NP_001073066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK28", "url": "https://www.uniprot.org/uniprotkb/E1BK28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAAF9", "url": "https://www.uniprot.org/uniprotkb/E1BK28", "locus": { "chromosome": "13", "start_pos": 51962387, "end_pos": 51733229, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003494", "url": "https://www.ensembl.org/id/ENSBTAG00000003494" } ] } } ], "crossref": [ { "id": "E1BK28", "url": "https://alphafold.ebi.ac.uk/entry/E1BK28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003494", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003494", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519774", "url": "https://www.ncbi.nlm.nih.gov/gene/519774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BK28", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BK28*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR040342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519774", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HPAGEKW", "url": "https://omabrowser.org/oma/group/HPAGEKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BK28", "url": "https://www.orthodb.org/?gene=E1BK28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33664", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33664", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33664:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33664:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23319", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23319", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25203", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25203", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073066", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S971", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S971", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S971-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S971-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK28", "url": "https://www.uniprot.org/uniprotkb/E1BK28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK28-1", "url": "https://www.uniprot.org/uniprotkb/E1BK28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAYPPHRVGLTRARSLGGLGRGSPSVSCSRLRQVQRILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLLGLYNQNASDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKIASFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPVVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPVSLESLLSEDLVAFEYQWTSFFANFDTEIPFLLELSESQAGEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPSGSFARHMVVQCVSPKGPLACSRTYFFGATHVPYLGDDNKLPKKTEQIRLLSQVYATVIEAVLAAIACYAKTSSLIKAKEVAEQTLGSGLNSVELMQFKATLRSKMAFHIHAVNNQGRIVPLDSEDSLYFVKTACMAIYDIPDLLGGRGCLGSVVFSESFLTSQILVKEKDGTVITETSFIILTAAIPRFCSWLVEDIEVKLSEKTQQSVLGDECFLGTFLTRGEGAYLYSSNSQSLPEEGKVHFFSNGLLFSDRHHGNIIISKDHMNSILFYDGDSTSVVAALLIDFKSSLLPHLPVYFHGSSNFLMIVLFPKSKIYQTFYSEVFSPWQQQTNSGLSLKVIQEDGLSVEQKRLHSRAQKLFSVLSHSAGEKQSPLKLLSAKLPELNGFLQHFAVSSISQEPVVRTHLPVLLQQAEINPIHRVENDKVIISIVTGLPGCHASELCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYVRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKSCFTIGTITVCVEPLSCYMEHRFLFPKFLDQCSQGLVSNVVFTSHTMEQRHPLLVQLQSLIRAANPSASFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLMYPGWYEGKFDAGSVFPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERMMEVCHNTLANSLSIVPVLEGPTPPPDSRTSPQSSSGQQECYLVFIGCSLKEESVKDWLRQSAKQKPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNRELEQQEYHDLFEQKP", "length": 1177, "header": "tr|E1BK28-1|E1BK28_BOVIN Isoform 1 of Dynein axonemal assembly factor 9 OS=Bos taurus OX=9913 GN=DNAAF9 PE=4 SV=1 CANONICAL=E1BK28-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S971-1", "url": "https://www.uniprot.org/uniprotkb/E1BK28/entry#A0AAA9S971-1", "sequence": { "sequence": "MRQENGICGPIMGQADMQPCLGFRKQCSSRPEMEPADSTTPHSKTEPRLDHHAHPSVVVLPVPELLLPEQRVLAAAQSGNGWTEERSGFASSSSSVSVALPCDDGDSKRTSEGCSRLRQVQRILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLLGLYNQNASDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKIASFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPVVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPVSLESLLSEDLVAFEYQWTSFFANFDTEIPFLLELSESQAGEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPSGSFARHMVVQCVSPKGPLACSRTYFFGATHVPYLGDDNKLPKKTEQIRLLSQVYATVIEAVLAAIACYAKTSSLIKAKEVAEQTLGSGLNSVELMQFKATLRSKMAFHIHAVNNQGRIVPLDSEDSLYFVKTACMAIYDIPDLLGGRGCLGSVVFSESFLTSQILVKEKDGTVITETSFIILTAAIPRFCSWLVEDIEVKLSEKTQQSVLGDECFLGTFLTRGEGAYLYSSNSQSLPEEGKVHFFSNGLLFSDRHHGNIIISKDHMNSILFYDGDSTSVVAALLIDFKSSLLPHLPVYFHGSSNFLMIVLFPKSKIYQTFYSEVFSPWQQQTNSGLSLKVIQEDGLSVEQKRLHSRAQKLFSVLSHSAGEKQSPLKLLSAKLPELNGFLQHFAVSSISQEPVVRTHLPVLLQQAEINPIHRVENDKVIISIVTGLPGCHASELCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYVRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKSCFTIGTITVCVEPLSCYMEHRFLFPKFLDQCSQGLVSNVVFTSHTMEQRHPLLVQLQSLIRAANPSASFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLMYPGWYEGKFDAGSVFPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERMMEVCHNTLANSLSIVPVLEGPTPPPDSRTSPQSSSGQQECYLVFIGCSLKEESVKDWLRQSAKQKPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNRELEQQEYHDLFEQKP", "length": 1262, "header": "tr|A0AAA9S971-1|A0AAA9S971_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 9 OS=Bos taurus OX=9913 GN=DNAAF9 PE=4 SV=1 CANONICAL=E1BK28-1" }, "locus": { "chromosome": "13", "start_pos": 51961383, "end_pos": 51733428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110124.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110124.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082620.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082620.1" } ] } }, { "isoform_ac": "A0AAA9TIW0-1", "url": "https://www.uniprot.org/uniprotkb/E1BK28/entry#A0AAA9TIW0-1", "sequence": { "sequence": "MDAYPPHRVGLTRARSLGGLGRGSPSVSCSRLRQVQRILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLLGLYNQNASDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKIASFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPVVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPVSLESLLSEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPSGSFARHMVVQCVSPKGPLACSRTYFFGATHVPYLGDDNKLPKKTEQIRLLSQVYATVIEAVLAAIACYAKTSSLIKAKEVAEQTLGSGLNSVELMQFKATLRSKMAFHIHAVNNQGRIVPLDSEDSLYFVKTACMAIYDIPDLLGGRGCLGSVVFSESFLTSQILVKEKDGTVITETSFIILTAAIPRFCSWLVEDIEVKLSEKTQQSVLGDECFLGTFLTRGEGAYLYSSNSQSLPEEGKVHFFSNGLLFSDRHHGNIIISKDHMNSILFYDGDSTSVVAALLIDFKSSLLPHLPVYFHGSSNFLMIVLFPKSKIYQTFYSEVFSPWQQQTNSGLSLKVIQEDGLSVEQKRLHSRAQKLFSVLSHSAGEKQSPLKLLSAKLPELNGFLQHFAVSSISQEPVVRTHLPVLLQQAEINPIHRVENDKVIISIVTGLPGCHASELCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYVRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKSCFTIGTITVCVEPLSCYMEHRFLFPKFLDQCSQGLVSNVVFTSHTMEQRHPLLVQLQSLIRAANPSASFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLMYPGWYEGKFDAGSVFPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERMMEVCHNTLANSLSIVPVLEGPTPPPDSRTSPQSSSGQQECYLVFIGCSLKEESVKDWLRQSAKQKPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNRELEQQEYHDLFEQKP", "length": 1144, "header": "tr|A0AAA9TIW0-1|A0AAA9TIW0_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 9 OS=Bos taurus OX=9913 GN=DNAAF9 PE=4 SV=1 CANONICAL=E1BK28-1" }, "locus": { "chromosome": "13", "start_pos": 51961383, "end_pos": 51791903, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126854.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126854.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096832.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096832.1" } ] } }, { "isoform_ac": "A0AAA9TP27-1", "url": "https://www.uniprot.org/uniprotkb/E1BK28/entry#A0AAA9TP27-1", "sequence": { "sequence": "MDCNTPAFTISQNLLRLISIESVMPSNHLILYRLLLLLPYLSQHRSLFHCSRLRQVQRILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLLGLYNQNASDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKIASFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPVVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPVSLESLLSEDLVAFEYQWTSFFANFDTEIPFLLELSESQAGEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPSGSFARHMVVQCVSPKGPLACSRTYFFGATHVPYLGDDNKLPKKTEQIRLLSQVYATVIEAVLAAIACYAKTSSLIKAKEVAEQTLGSGLNSVELMQFKATLRSKMAFHIHAVNNQGRIVPLDSEDSLYFVKTACMAIYDIPDLLGGRGCLGSVVFSESFLTSQILVKEKDGTVITETSFIILTAAIPRFCSWLVEDIEVKLSEKTQQSVLGDECFLGTFLTRGEGAYLYSSNSQSLPEEGKVHFFSNGLLFSDRHHGNIIISKDHMNSILFYDGDSTSVVAALLIDFKSSLLPHLPVYFHGSSNFLMIVLFPKSKIYQTFYSEVFSPWQQQTNSGLSLKVIQEDGLSVEQKRLHSRAQKLFSVLSHSAGEKQSPLKLLSAKLPELNGFLQHFAVSSISQEPVVRTHLPVLLQQAEINPIHRVENDKVIISIVTGLPGCHASELCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYVRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKSCFTIGTITVCVEPLSCYMEHRFLFPKFLDQCSQGLVSNVVFTSHTMEQRHPLLVQLQSLIRAANPSASFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLMYPGWYEGKFDAGSVFPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERMMEVCHNTLANSLSIVPVLEGPTPPPDSRTSPQSSSGQQECYLVFIGCSLKEESVKDWLRQSAKQKPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNRELEQQEYHDLFEQKP", "length": 1198, "header": "tr|A0AAA9TP27-1|A0AAA9TP27_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 9 OS=Bos taurus OX=9913 GN=DNAAF9 PE=4 SV=1 CANONICAL=E1BK28-1" }, "locus": { "chromosome": "13", "start_pos": 51961383, "end_pos": 51797663, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098779.1" } ] } }, { "isoform_ac": "E1BK28-1", "url": "https://www.uniprot.org/uniprotkb/E1BK28/entry#E1BK28-1", "sequence": { "sequence": "MDAYPPHRVGLTRARSLGGLGRGSPSVSCSRLRQVQRILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLLGLYNQNASDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKIASFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPVVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPVSLESLLSEDLVAFEYQWTSFFANFDTEIPFLLELSESQAGEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPSGSFARHMVVQCVSPKGPLACSRTYFFGATHVPYLGDDNKLPKKTEQIRLLSQVYATVIEAVLAAIACYAKTSSLIKAKEVAEQTLGSGLNSVELMQFKATLRSKMAFHIHAVNNQGRIVPLDSEDSLYFVKTACMAIYDIPDLLGGRGCLGSVVFSESFLTSQILVKEKDGTVITETSFIILTAAIPRFCSWLVEDIEVKLSEKTQQSVLGDECFLGTFLTRGEGAYLYSSNSQSLPEEGKVHFFSNGLLFSDRHHGNIIISKDHMNSILFYDGDSTSVVAALLIDFKSSLLPHLPVYFHGSSNFLMIVLFPKSKIYQTFYSEVFSPWQQQTNSGLSLKVIQEDGLSVEQKRLHSRAQKLFSVLSHSAGEKQSPLKLLSAKLPELNGFLQHFAVSSISQEPVVRTHLPVLLQQAEINPIHRVENDKVIISIVTGLPGCHASELCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYVRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKSCFTIGTITVCVEPLSCYMEHRFLFPKFLDQCSQGLVSNVVFTSHTMEQRHPLLVQLQSLIRAANPSASFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLMYPGWYEGKFDAGSVFPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERMMEVCHNTLANSLSIVPVLEGPTPPPDSRTSPQSSSGQQECYLVFIGCSLKEESVKDWLRQSAKQKPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNRELEQQEYHDLFEQKP", "length": 1177, "header": "tr|E1BK28-1|E1BK28_BOVIN Isoform 1 of Dynein axonemal assembly factor 9 OS=Bos taurus OX=9913 GN=DNAAF9 PE=4 SV=1 CANONICAL=E1BK28-1" }, "locus": { "chromosome": "13", "start_pos": 51961383, "end_pos": 51791903, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061472.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061472.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053813.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053813.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1045, "start_aa": "Thr", "end_pos": 1045, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1045", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:519774", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519774", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B8JIN4-1", "protein_name": "Dynein axonemal assembly factor 9", "gene_name": "dnaaf9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLSKYQTTNMAAIRKNKSSIMTAAVSCSRLRQVQALLRDDVNTAPDGILCSLGIDSRYNEGCSELASYLFCGLYNHNHFDMEQIPEDFPEEVLDDVIILIKAECVHLYCNPVNYGYLLPYVSHWRNLQLHCLTETEYEDEEVAEEFKISSFVSMVQDCHCIGIPYSSHGHVQKFDMFMLEKWPIIQAFALEGIGAGLFFTMKYKLKDVSQRLWQVYSRLDPVSLDCLLNEDLQLFERQWSCLFSSMEIESALSMQELSEAQVAEPFRTYYSHGLISSNITDKSKSRQPFVLFGSHSTKEDLESYCFTFPSEGHQVRNTGPSGGVAKHMLLQCVAPKGPLACARTYFFGNTHVPYLGNNNTQQRRTDLQVLSHIYSAAIQSVLAGIKCFSINSSASKAKDVADQTFQLALESFGLIQYKGALRSKAVFSIQAVNNKGSIVPLSDEDSHFLVKTASMMVYDIPDLQCGGNLGSVVFSESFLESSVYIQQRDGALSSDSCFTVLTSSIPRYVSWLVDEAEVRMSEQAQHLLKAEDSTCLGIPITVRDSAYMFSNSLLSTPEEGKLVFFSEGILFVHPHHGSITLSMSHINSIKLYDGASLSDISMLFIEYQTSLLPHLPFPLHSSDFSLAVALLPRTKSYKSFYSQVLPAWRKSESGLRVQHVLNDQLSPEHKSMYFRLLKLHETHAVPANHRVVLRTAYPQLPEQDRFLQHFAISSSVDEESVCSDHLSTVFSDTIPESTKPEPKKKVVLTIIAGLPGSHKENLCDFLMEVNQNSSRWEVFCPALEGSGEFSASHLQRFLSSLLAKQRETDMNSFRVVLLIPGYTDIMDVIQAITAHPDPQVHSQVTVGAVSACVNPLTSFIKHRLLFPKLLEQCSQGIVSNVVFTGLTMEQKHPLLQHMQQLIRAANLSTAFISAEKGAVRRTEDLRLILNDSSFSQPHMVNARYLLYPGWWEGRFVSGSGSLSMSQHRVEFSRPLERALFLQRCKALKSSLKPSPFTGNIYHISGKVLFSDNDRQMVVNCNSISGNVTVAPDQGTHHGLWTTNNCYLMFHGVGLTQEGLKDWLRHCAKQKIVKKVKKNQRTLTTEEIKYIHLKRHLDPLPPGYFYNGHHFVSFFGEKQNFHPLMDRFIDEYVQDANKEIERFNREVDLQPHADLFDP", "length": 1157 }, "evidence": [ { "id": "E1BK28", "url": "https://omabrowser.org/oma/group/E1BK28/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZVN5-1", "protein_name": "Dynein axonemal assembly factor 9", "gene_name": "Dnaaf9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSFAPQQPGLSRARLAGTFGRGAASVSCSRLRQVQSVLTQSSKSQPDGILCILGIDSRYNEGCRELANYLLFGLYSQNTTDFEKTGFSEEILDDVIMLIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKISSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPIVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSRMDPMSLENMLSKDLAVFEHQWTSFFANFDIEIPFLLELSESQAGEPFRSYFSHGMISSHVTENSPHRQPFVLFGTHSTRDNLRTGSFNFPSEGHLVRNTGPAGSIAKHMVAQCVSPKGPLACSRTYFFGATHVPYLGDDEKLPRTTEQIRLLSQVYAAVTEAVLAAIACYAKTCSLAKAKEVAEQTLESGLVFTELVPFKAELRSKVAFHIHAVNNQGRIVPLNNEDSLSFVKTASMSVYDIPDVLGGGGCLGSVVFSESFLTSQILVKEKDGTITPETSYIILTAAIPRFCSWLVEDNEVKLCEKTLQATKGDDCFLGTLLTGGKGAYLYSNSLQSRPEEGNVYFFSGGLLFSHRHHASVVISKDHMNSVSFYDGDSTSVVAALLIDFRSSILPHLPVHFHGSSNFLMIALFPRSKIYQAFYSEVFSPWQQQDNSGLSLKVIQEDGLSVEQKKLYSNAQKLFSALSHPAQDWSSPKLLSAKLPELDRFLQHFALGSIGQEPVMRAHLLSLLQQAETSPTHRLESDKVVISIVTGLPGCHASKLCAFLVTLHKEYGRWMVYRQVMDSSECFHAAHFQKYLSSALEAQQNRSARQSAYIRKKTRLLVALQGYTDVIDVVQALQTHPDPNVKSYFTIGAVTVCVEPLSCYMEHRFLFPKCLDQCSQGVVSNVVFTSHTTEQRHPLLVELQTLIRASNPTAAFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLLFPGWYEGKFDAGSVFPLMVQICVWFDRPLEKTRFVTKCKAIQSSLKPSPFSGNIYHILGKVKFSDSEKTMEVCHNTLTNSLTIVPVLEGPTPPPNSRSTPQDNGQPECYLVFIGCSLKEDSLKDWLRQSAKQRPQRKALKTRGMLTQQEIRNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIERYNRELEQQEYRDLFEQKP", "length": 1175 }, "evidence": [ { "id": "E1BK28", "url": "https://omabrowser.org/oma/group/E1BK28/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5TEA3-1", "protein_name": "Dynein axonemal assembly factor 9", "gene_name": "DNAAF9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVYPPRRQGLPRARSPGGSSRGSPSVSCSRLRQVQSILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLFGLYNQNTSDFEKTGFSEEVLDDVIILIKSDSVHLYCNPVNFRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKITSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPIVQAFALEGIGGDGFFTMKYELQDVSLNLWNVYSKMDPMSLESLLSDDLVAFEHQWTSFFANFDTEIPFLLELSESQAGEPFRSYFSHGMISSHITENSPNRQPFVLFGNHSTRENLNAGNFNFPSEGHLVRSTGPGGSFAKHMVAQCVSPKGPLACSRTYFFGATHVPYLGGDSKLPKKTEQIRLLSQIYAAVIEAVLAGIACYAKTSSLTKAKEVAEQTLGSGLDSFELIPFKAALRSKMTFHIHAVNNQGRIVPLDSEDSLSFVKTACMAVYDIPDLLGGNGCLGSVVFSESFLTSQILVKEKDGTVTTETSSVVLTAAVPRFCSWLVEDNEVKLSEKTQQAVRGDESFLGTYLTGGEGAYLYSSNLQSWPEEGNVHFFSSGLLFSHCRHRSIIISKDHMNSISFYDGDSTSTVAALLIDFKSSLLPHLPVHFHGSSNFLMIALFPKSKIYQAFYSEVFSLWKQQDNSGISLKVIQEDGLSVEQKRLHSSAQKLFSALSQPAGEKRSSLKLLSAKLPELDWFLQHFAISSISQEPVMRTHLPVLLQQAEINTTHRIESDKVIISIVTGLPGCHASELCAFLVTLHKECGRWMVYRQIMDSSECFHAAHFQRYLSSALEAQQNRSARQSAYIRKKTRLLVVLQGYTDVIDVVQALQTHPDSNVKASFTIGAITACVEPMSCYMEHRFLFPKCLDQCSQGLVSNVVFTSHTTEQRHPLLVQLQSLIRAANPAAAFILAENGIVTRNEDIELILSENSFSSPEMLRSRYLMYPGWYEGKLNAGSVYPLMVQICVWFGRPLEKTRFVAKCKAIQSSIKPSPFSGNIYHILGKVKFSDSERTMEVCYNTLANSLSIMPVLEGPTPPPDSKSVSQDSSGQQECYLVFIGCSLKEDSIKDWLRQSAKQKPQRKALKTRGMLTQQEIRSIHVKRHLEPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIEKYNQELEQQEYHDLFELKP", "length": 1177 }, "evidence": [ { "id": "E1BK28", "url": "https://omabrowser.org/oma/group/E1BK28/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TT23-1", "protein_name": "Dynein axonemal assembly factor 9", "gene_name": "Dnaaf9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSFDPQQLGLSPARFAGTFGSGAASVSCSRLRQVQSVLTQSSKSQPDGILCILGIDSRYNEGCRELANYLLFGLYSQNATDFEKTGFSEEILDDVILLIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKISSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPIVQAFALEGIGGDGFFTMKYELQDVSLSLWNVYSRMDPASLENMLSEDLAVFEHQWTSFFANFDTEIPFLLELSESQAGEPFRSYFGHGMLSSHITENSPHRQPFVLFGNHSTRDNLSAGSFNFPSEGHLVRNTGPAGSFAKHMVAQCVSPKGPLACSRTYFFGATHVPYLGDNEKLPRTTEQIRLLSQIYAAVIEAVLAGIACYAKTCSLAKAKEVAEHTLESGLVFTELVPFKADLRSKVTFHIHAVNNQGRIVPLNNEDSLSFVKTARMTVYDIPDLLGGGGGGCLGSVVFSESFLTSRILVKEKDGTITPETSYIILTAAIPRFCSWLVEDSEIKLSEKTLQATKGDDCCLGTLLTGGKGAYLYSNSPQSGPEEGSAYFFSGGLLFSHRHHGSIVIAKEHVDAFSFYDGDSTSVVAALLIHFRSSILPHLPVHFHGSSNFLMLALFPKSKIYQAFYSEVFSPWQQQDNSGLSLKVIQEDGLSAEQKRLHSNAQKLFSALSPPAQDWSSPKLLSGKLPELDRFLQHFAIGSIGQEPVMRAHLVGLLQQPEMSPAHEVESDKVVISIVTGLPGCHASKLCAFLITLHKEYGRWMVYRQIMDSSECFHAAHFQKYLSSALEAQQNRSARQSAYIRKKTRLLVVLQGYTDVIDVVQALQTHPDPNVRSYFTIGAVTVCVEPLSCYMEHRFLFPKCLDQCSQGVVSNVVFTSHTAEQKHPLLVQLQTLIRASNPTAAFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLLFPGWYEGKFDAGSVFPLMVQICVWFDCPLEKTRFVSRCRAIQSSIKPSPFSGNIYHILGKVKFSDSEKTMEVCHNTLTNSLTIVPVLEGPTPPPNSRSSPQDNGQPECYLVFIGCSLKEDSLKDWLRQSAKQRPQRKALKTRGMLTQQEIKNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIERYNRELEQQEYRDLFEQKPKP", "length": 1179 }, "evidence": [ { "id": "E1BK28", "url": "https://omabrowser.org/oma/group/E1BK28/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK28-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1177, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK28-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK28" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" }, { "id": "PF25204", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25204" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAAF9", "eco_id": "ECO_0000259", "start_pos": 749, "end_pos": 958, "start_aa": "Ile", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" }, { "id": "PF23319", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23319" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAAF9 CobW C-like", "eco_id": "ECO_0000259", "start_pos": 974, "end_pos": 1040, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" }, { "id": "PF23281", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23281" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAAF9 N-terminal", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 217, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" }, { "id": "PF26246", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26246" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAAF9 PH", "eco_id": "ECO_0000259", "start_pos": 516, "end_pos": 720, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BK28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK28" }, { "id": "PF25203", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25203" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAAF9 pita-bread-like", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 500, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1045 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1124, "end_pos": 1126 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 79, "end_pos": 81 }, { "start_pos": 808, "end_pos": 810 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK31-1", "uniprot_ac": "E1BK31", "uniprot_id": "E1BK31_BOVIN", "mass": { "chemical_mass": 46179.0, "monoisotopic_mass": 46179.0 }, "refseq": { "ac": "NP_001179974", "name": "glucose-6-phosphate exchanger SLC37A4 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974" }, "gene_names": [ { "name": "SLC37A4", "type": "recommended", "evidence": [ { "id": "E1BK31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ] }, { "name": "G6PT1", "type": "synonym", "evidence": [ { "id": "NP_001179974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974" } ] }, { "name": "SLC37A4", "type": "synonym", "evidence": [ { "id": "NP_001179974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974" } ] } ], "protein_names": [ { "name": "Solute carrier family 37 member 4", "type": "synonym", "evidence": [ { "id": "E1BK31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK31/entry#names_and_taxonomy" } ] }, { "name": "glucose-6-phosphate exchanger SLC37A4 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001179974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974" } ] }, { "name": "glucose-6-phosphate translocase", "type": "synonym", "evidence": [ { "id": "NP_001179974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC37A4", "url": "https://www.uniprot.org/uniprotkb/E1BK31", "locus": { "chromosome": "15", "start_pos": 29594433, "end_pos": 29599909, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008077", "url": "https://www.ensembl.org/id/ENSBTAG00000008077" } ] } } ], "crossref": [ { "id": "E1BK31", "url": "https://alphafold.ebi.ac.uk/entry/E1BK31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506423", "url": "https://www.ncbi.nlm.nih.gov/gene/506423", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506423", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506423", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NAWFQGW", "url": "https://omabrowser.org/oma/group/NAWFQGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIP1", "url": "https://www.orthodb.org/?gene=A0A3Q1LIP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BK31", "url": "https://www.orthodb.org/?gene=E1BK31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43826", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43826", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43826:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43826:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179974", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIP1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK31-1", "url": "https://www.uniprot.org/uniprotkb/E1BK31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIVFSWSSAVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRATLALSGALCVAVSFLCLLLIRNEPADVGLQNLDPTPSKGKKGSSKEESTLQELLLTPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSIYGNPRHGLLLFMMAGMTASMYLFRATVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANECAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTGAFFLLRNIRTKMGRVPKKAE", "length": 429, "header": "tr|E1BK31-1|E1BK31_BOVIN Isoform 1 of Solute carrier family 37 member 4 OS=Bos taurus OX=9913 GN=SLC37A4 PE=3 SV=2 CANONICAL=E1BK31-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BK31/entry#A0A3Q1LIP1-1", "sequence": { "sequence": "MAARGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIVFSWSSAVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRATLALSGALCVAVSFLCLLLIRNEPADVGLQNLDPTPSKGKKGSSKEESTLQELLLTPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSIYGNPRHGLLLFMMAGMTASMYLFRATVTSDSPKDTAFWTPALHPLAEITGFTENELWILVLGAVFGFSSYGPIALFGVIANECAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTGAFFLLRNIRTKMGRVPKKAE", "length": 451, "header": "tr|A0A3Q1LIP1-1|A0A3Q1LIP1_BOVIN Computationally mapped isoform of Solute carrier family 37 member 4 OS=Bos taurus OX=9913 GN=SLC37A4 PE=3 SV=1 CANONICAL=E1BK31-1" }, "locus": { "chromosome": "15", "start_pos": 29599716, "end_pos": 29595390, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077820.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077820.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058973.1" } ] } }, { "isoform_ac": "E1BK31-1", "url": "https://www.uniprot.org/uniprotkb/E1BK31/entry#E1BK31-1", "sequence": { "sequence": "MAARGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIVFSWSSAVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRATLALSGALCVAVSFLCLLLIRNEPADVGLQNLDPTPSKGKKGSSKEESTLQELLLTPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSIYGNPRHGLLLFMMAGMTASMYLFRATVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANECAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTGAFFLLRNIRTKMGRVPKKAE", "length": 429, "header": "tr|E1BK31-1|E1BK31_BOVIN Isoform 1 of Solute carrier family 37 member 4 OS=Bos taurus OX=9913 GN=SLC37A4 PE=3 SV=2 CANONICAL=E1BK31-1" }, "locus": { "chromosome": "15", "start_pos": 29599716, "end_pos": 29595390, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061244.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061244.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053810.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053810.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 202, "start_aa": "Thr", "end_pos": 202, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr202", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506423", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506423", "resource": "KEGG Pathway" }, { "id": "R-BTA-70263", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "resource": "Reactome", "description": "Gluconeogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTY3-1", "protein_name": "Solute carrier family 37 member 4", "gene_name": "Slc37a4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAITALSYSQPCSEATAFTTSTAKPSLLSCPPWWMRSLWTRTIWVSCSLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKEAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE", "length": 455 }, "evidence": [ { "id": "E1BK31", "url": "https://omabrowser.org/oma/group/E1BK31/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A3L7HSK5-1", "protein_name": "Glucose-6-phosphate exchanger SLC37A4 isoform X1", "gene_name": "Slc37a4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAQGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVEEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVPVFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVAVSFLCLLLIHNEPADVGLRNLDPTPSKGKKDSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHGLLLFMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTLVFFLLRNIRTKMGRVPKKAE", "length": 429 }, "evidence": [ { "id": "E1BK31", "url": "https://omabrowser.org/oma/group/E1BK31/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1A7V4-1", "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "SLC37A4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVGGYGRYRAVIFTAMFVGYTLYYFNRKTFSFVMPAVMAEVPLDKDDLGLITSSQSAAYAISKFVSGVLSDRLSARWLFAAGLLLVGVVNVLFSWSGSVGAFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALVSLNYDWRMTLSFSGFICVIVSFVCLVLIKNEPADVGLPNIDQGTKKGKKGSPSDNSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSMLVGSSYMSALEIGGLVGSIAAGYLSDRAVAKVGLSNYGNPRHTLLLSMMAGMCVSMFLFRVTITGNSPKLWILTLGAVFGFSSYGPIALFGVIANESAPANLCGTSHAIVALMANGSSGRRACGASFLGRHLGSSSSRSMPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLGKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA", "length": 523 }, "evidence": [ { "id": "E1BK31", "url": "https://omabrowser.org/oma/group/E1BK31/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43826-1", "protein_name": "Glucose-6-phosphate exchanger SLC37A4", "gene_name": "SLC37A4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKAE", "length": 429 }, "evidence": [ { "id": "E1BK31", "url": "https://omabrowser.org/oma/group/E1BK31/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "glucose-6-phosphate transport", "id": "GO:0015760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015760", "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "pmid": "" }, { "name": "phosphate ion transmembrane transport", "id": "GO:0035435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035435", "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "pmid": "" }, { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glucose 6-phosphate:phosphate antiporter activity", "id": "GO:0061513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061513", "evidence": [ { "database": "UniProtKB", "id": "E1BK31", "url": "https://www.uniprot.org/uniprotkb/E1BK31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK31-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 429, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK31-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK31" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BK31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK31" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 419, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 202 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK39-1", "uniprot_ac": "E1BK39", "uniprot_id": "E1BK39_BOVIN", "mass": { "chemical_mass": 22149.0, "monoisotopic_mass": 22149.0 }, "refseq": { "ac": "NP_001192555", "name": "uncharacterized protein C2orf80 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192555" }, "gene_names": [ { "name": "C2H2orf80", "type": "recommended", "evidence": [ { "id": "E1BK39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK39" } ] }, { "name": "C2H2orf80", "type": "synonym", "evidence": [ { "id": "NP_001192555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192555" } ] } ], "protein_names": [ { "name": "Chromosome 2 C2orf80 homolog", "type": "synonym", "evidence": [ { "id": "E1BK39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#names_and_taxonomy" } ] }, { "name": "hCG1641896-like", "type": "synonym", "evidence": [ { "id": "NP_001192555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192555" } ] }, { "name": "uncharacterized protein C2orf80 homolog", "type": "synonym", "evidence": [ { "id": "NP_001192555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192555" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK39", "url": "https://www.uniprot.org/uniprotkb/E1BK39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C2H2orf80", "url": "https://www.uniprot.org/uniprotkb/E1BK39", "locus": { "chromosome": "2", "start_pos": 96437059, "end_pos": 96463365, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012888", "url": "https://www.ensembl.org/id/ENSBTAG00000012888" } ] } } ], "crossref": [ { "id": "E1BK39", "url": "https://alphafold.ebi.ac.uk/entry/E1BK39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012888", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012888", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539078", "url": "https://www.ncbi.nlm.nih.gov/gene/539078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LDDMVHY", "url": "https://omabrowser.org/oma/group/LDDMVHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BK39", "url": "https://www.orthodb.org/?gene=E1BK39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36296:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36296:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17718", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17718", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKH6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKH6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC76", "url": "https://www.uniprot.org/uniprotkb/E1BC76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC76-1", "url": "https://www.uniprot.org/uniprotkb/E1BC76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK39", "url": "https://www.uniprot.org/uniprotkb/E1BK39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK39-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERRLLKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 194, "header": "tr|E1BK39-1|E1BK39_BOVIN Isoform 1 of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=2 CANONICAL=E1BK39-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#A0AAA9SDK4-1", "sequence": { "sequence": "MIRMNTDLVLSFLAHRRQVTYPGLPPVPCVHWTLCPGGPSPTEILFILQAQLCRSLFSESLGILPTHQAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 221, "header": "tr|A0AAA9SDK4-1|A0AAA9SDK4_BOVIN Computationally mapped isoform of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=1 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96455731, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126116.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126116.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080427.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080427.1" } ] } }, { "isoform_ac": "A0AAA9SK05-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#A0AAA9SK05-1", "sequence": { "sequence": "MRSYYKTVLIQEVWGEAGDNAFLMSKQAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 180, "header": "tr|A0AAA9SK05-1|A0AAA9SK05_BOVIN Computationally mapped isoform of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=1 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96456142, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084184.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084184.1" } ] } }, { "isoform_ac": "A0AAA9SQA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#A0AAA9SQA7-1", "sequence": { "sequence": "GCSSTPPEAQREQKHWDLAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 171, "header": "tr|A0AAA9SQA7-1|A0AAA9SQA7_BOVIN Computationally mapped isoform of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=1 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96463365, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096569.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096569.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088517.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088517.1" } ] } }, { "isoform_ac": "A0ABI0NKH6-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#A0ABI0NKH6-1", "sequence": { "sequence": "MTERLTTPVCARQTHSARKNMKLMTSGLNPLFKRKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 159, "header": "tr|A0ABI0NKH6-1|A0ABI0NKH6_BOVIN Computationally mapped isoform of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=1 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96454180, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136659.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136659.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104923.1" } ] } }, { "isoform_ac": "E1BC76-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#E1BC76-1", "sequence": { "sequence": "MERRLLKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVT", "length": 124, "header": "tr|E1BC76-1|E1BC76_BOVIN Computationally mapped isoform of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=4 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96460352, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044265.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044265.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041774.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041774.5" } ] } }, { "isoform_ac": "E1BK39-1", "url": "https://www.uniprot.org/uniprotkb/E1BK39/entry#E1BK39-1", "sequence": { "sequence": "MERRLLKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAINVALQWLDHSEDLTWLEWEKAKMSFRGRPIYPNHREREAMILSSYAGILMNSIPIEEVFKIYGAGSSSSSGAAKVPRAPPFRLSLHPFAMLTAPKAAEYASKQSVKLRRAAMNKNATSSSTRKANAMEWKSSKNLSLDTQLKDKVT", "length": 194, "header": "tr|E1BK39-1|E1BK39_BOVIN Isoform 1 of Chromosome 2 C2orf80 homolog OS=Bos taurus OX=9913 GN=C2H2orf80 PE=4 SV=2 CANONICAL=E1BK39-1" }, "locus": { "chromosome": "2", "start_pos": 96460352, "end_pos": 96437520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035293.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035293.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035171.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035171.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539078", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZZY3-1", "protein_name": "Chromosome 15 C2orf80 homolog", "gene_name": "C15H2orf80", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRRLLKKEIKKLLRDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAISAALQWVDHSEDLTWLEWEEVKMPFRGRPIYPNHREREAMILSSFAGILMNSIPIEEVFKIYGADASASSGTAKVPRAPPFRLSLHPFAMLTAPKAAEYARKQSVKLGRGAMNKNATSGSTRRANAMEWKSSKKLSLNTQPKNKVT", "length": 194 }, "evidence": [ { "id": "E1BK39", "url": "https://omabrowser.org/oma/group/E1BK39/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q0P641-1", "protein_name": "Uncharacterized protein C2orf80", "gene_name": "C2orf80", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERRLIKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAISVALQWLDPSEDLTWLEWEELKIPLHGRPIYPNRREREAMILSSYAGILMNSIPIEEVFKIYGADSSADSGTIKVPRVSSLCLSLHPFAMLTAPKAAAYARKQSVKSRKVTTNKNATSISAKEANATEWKSSQRFSDTQPKHKVT", "length": 193 }, "evidence": [ { "id": "E1BK39", "url": "https://omabrowser.org/oma/group/E1BK39/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C3M9-1", "protein_name": "Uncharacterized protein C2orf80 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERRLVKQEVKRLLGEYIGIRLRENEFDPKGRGQLTFLDDMVNQVTLAHYDLAISVASQWLDCSENLTWLQWEKVRAPLHVRPAYPNRKEREAMILSSYAGVLMNSIPIEEVLKIYGANSSASPDSTKVAQALLPRRSLHPFAMLTAPRAAECNRRQSVKLRRGATNKNTTSSSTKKATGQNGDPVGKGTHTPATNISPTPVLSSAQPFHSSTVMWRNLESAQRQMGLEGK", "length": 231 }, "evidence": [ { "id": "E1BK39", "url": "https://omabrowser.org/oma/group/E1BK39/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK39-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK39-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK39" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 182, "end_pos": 184 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK43-1", "uniprot_ac": "E1BK43", "uniprot_id": "E1BK43_BOVIN", "mass": { "chemical_mass": 200234.0, "monoisotopic_mass": 200234.0 }, "refseq": { "ac": "XP_024855929", "name": "sodium leak channel NALCN isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855929" }, "gene_names": [ { "name": "NALCN", "type": "recommended", "evidence": [ { "id": "E1BK43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ] }, { "name": "NALCN", "type": "synonym", "evidence": [ { "id": "XP_024855929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855929" } ] } ], "protein_names": [ { "name": "Sodium leak channel NALCN", "type": "recommended", "evidence": [ { "id": "E1BK43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#names_and_taxonomy" } ] }, { "name": "Sodium leak channel non-selective protein", "type": "synonym", "evidence": [ { "id": "E1BK43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#names_and_taxonomy" } ] }, { "name": "Voltage gated channel-like protein 1", "type": "synonym", "evidence": [ { "id": "E1BK43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#names_and_taxonomy" } ] }, { "name": "sodium leak channel NALCN isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024855929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855929" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NALCN", "url": "https://www.uniprot.org/uniprotkb/E1BK43", "locus": { "chromosome": "12", "start_pos": 77565983, "end_pos": 77868716, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037786", "url": "https://www.ensembl.org/id/ENSBTAG00000037786" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037786", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037786", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536103", "url": "https://www.ncbi.nlm.nih.gov/gene/536103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR46141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46141:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46141:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855929", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855929", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LL71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MW10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MW10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK43-1", "url": "https://www.uniprot.org/uniprotkb/E1BK43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQQMMRSSVFHMFILSMVTVDVIVAASNYHKGESFKRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHAYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPSTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHTPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLLVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPMHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIMAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIISLKQSQQQELKRILNPPSIETTQPSEDLKTNSQDNSVQPESSSQQQLLSPTLSDRGGGRQDAAEAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDTASCGSEVKKWWTRQLTVESDESGDDLLDI", "length": 1738, "header": "tr|E1BK43-1|E1BK43_BOVIN Isoform 1 of Sodium leak channel NALCN OS=Bos taurus OX=9913 GN=NALCN PE=3 SV=4 CANONICAL=E1BK43-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL71-1", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#A0A3Q1LL71-1", "sequence": { "sequence": "MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQQMMRSSVFHMFILSMVTVDVIVAASNYHKGESFKRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHAYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPSTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHTPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLLVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPMHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIMAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIISLKQSQQQELKRILNPPSIETTQPSEDLKTNSQDNSVQPESSSQQQLLSPTLSDRGGGRQDAAEAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDTASCGSEVKKWWTRQLTVESDESGDDLLDI", "length": 1709, "header": "tr|A0A3Q1LL71-1|A0A3Q1LL71_BOVIN Computationally mapped isoform of Sodium leak channel NALCN OS=Bos taurus OX=9913 GN=NALCN PE=3 SV=2 CANONICAL=E1BK43-1" }, "locus": { "chromosome": "12", "start_pos": 77847326, "end_pos": 77566987, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082451.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082451.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057519.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057519.2" } ] } }, { "isoform_ac": "A0A3Q1MW10-1", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#A0A3Q1MW10-1", "sequence": { "sequence": "MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQQMMRSSVFHMFILSMVTVDVIVAASNYHKGESFKRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHAYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHTPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLLVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPMHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIMAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIISLKQSQQQELKRILNPPSIETTQPSEDLKTNSQDNSVQPESSSQQQLLSPTLSDRGGGRQDAAEAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDTASCGSEVKKWWTRQLTVESDESGDDLLDI", "length": 1645, "header": "tr|A0A3Q1MW10-1|A0A3Q1MW10_BOVIN Computationally mapped isoform of Sodium leak channel NALCN OS=Bos taurus OX=9913 GN=NALCN PE=3 SV=2 CANONICAL=E1BK43-1" }, "locus": { "chromosome": "12", "start_pos": 77847326, "end_pos": 77566987, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084484.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084484.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059450.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059450.2" } ] } }, { "isoform_ac": "E1BK43-1", "url": "https://www.uniprot.org/uniprotkb/E1BK43/entry#E1BK43-1", "sequence": { "sequence": "MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQQMMRSSVFHMFILSMVTVDVIVAASNYHKGESFKRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHAYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPSTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHTPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLLVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPMHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIMAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIISLKQSQQQELKRILNPPSIETTQPSEDLKTNSQDNSVQPESSSQQQLLSPTLSDRGGGRQDAAEAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDTASCGSEVKKWWTRQLTVESDESGDDLLDI", "length": 1738, "header": "tr|E1BK43-1|E1BK43_BOVIN Isoform 1 of Sodium leak channel NALCN OS=Bos taurus OX=9913 GN=NALCN PE=3 SV=4 CANONICAL=E1BK43-1" }, "locus": { "chromosome": "12", "start_pos": 77847326, "end_pos": 77566987, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061374.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061374.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053801.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053801.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536103", "resource": "KEGG Pathway" }, { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of synaptic transmission, cholinergic", "id": "GO:0032224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032224", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" }, { "name": "positive regulation of synaptic transmission, GABAergic", "id": "GO:0032230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032230", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" }, { "name": "regulation of neuronal action potential", "id": "GO:0098908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098908", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "monoatomic cation channel activity", "id": "GO:0005261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005261", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" }, { "name": "voltage-gated sodium channel activity", "id": "GO:0005248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005248", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" }, { "name": "sodium channel activity", "id": "GO:0005272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005272", "evidence": [ { "database": "UniProtKB", "id": "E1BK43", "url": "https://www.uniprot.org/uniprotkb/E1BK43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1064, "end_pos": 1066, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1371, "end_pos": 1373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1449, "end_pos": 1451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 859, "end_pos": 861, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "34963", "name": "", "equation": "Na(+)(in) = Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "34963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34963" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BK43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK43" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 331, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1064, "end_pos": 1066 }, { "start_pos": 1371, "end_pos": 1373 }, { "start_pos": 1449, "end_pos": 1451 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 859, "end_pos": 861 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK68-1", "uniprot_ac": "E1BK68", "uniprot_id": "E1BK68_BOVIN", "mass": { "chemical_mass": 93699.0, "monoisotopic_mass": 93699.0 }, "refseq": { "ac": "XP_002691259", "name": "F-box only protein 41", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691259" }, "gene_names": [ { "name": "FBXO41", "type": "recommended", "evidence": [ { "id": "E1BK68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK68" } ] }, { "name": "FBXO41", "type": "synonym", "evidence": [ { "id": "XP_002691259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691259" } ] } ], "protein_names": [ { "name": "F-box only protein 41", "type": "recommended", "evidence": [ { "id": "E1BK68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK68/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 41", "type": "synonym", "evidence": [ { "id": "XP_002691259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691259" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "E1BK68", "url": "https://www.uniprot.org/uniprotkb/E1BK68#function" }, { "database": "UniProtKB", "id": "ARBA00003437", "url": "https://www.uniprot.org/uniprotkb/ARBA00003437#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK68", "url": "https://www.uniprot.org/uniprotkb/E1BK68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO41", "url": "https://www.uniprot.org/uniprotkb/E1BK68", "locus": { "chromosome": "11", "start_pos": 11192873, "end_pos": 11168086, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012759", "url": "https://www.ensembl.org/id/ENSBTAG00000012759" } ] } } ], "crossref": [ { "id": "E1BK68", "url": "https://alphafold.ebi.ac.uk/entry/E1BK68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012759", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012759", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22109", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22109", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536077", "url": "https://www.ncbi.nlm.nih.gov/gene/536077", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536077", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536077", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGTTPNC", "url": "https://omabrowser.org/oma/group/CGTTPNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BK68", "url": "https://www.orthodb.org/?gene=E1BK68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15739:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15739:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002691259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691259", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BK68", "url": "https://www.uniprot.org/uniprotkb/E1BK68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK68-1", "url": "https://www.uniprot.org/uniprotkb/E1BK68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAFPLAPEPAALLAVPGARREVFESTSFQGKEQAVGQSSAAPHLLHHHHHHAPLAHFPGDLVPAGLPCEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGAGAGPSTRAPGRMREHHAGPAMPSTYAVSRHGSSPSTGASSRIPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRVQAANGGSERAQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSEVPRPGPAMAGPVSSCRLSARPEGGSGRGRRAERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPMRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGC", "length": 863, "header": "tr|E1BK68-1|E1BK68_BOVIN Isoform 1 of F-box only protein 41 OS=Bos taurus OX=9913 GN=FBXO41 PE=4 SV=1 CANONICAL=E1BK68-1" }, "isoforms": [ { "isoform_ac": "E1BK68-1", "url": "https://www.uniprot.org/uniprotkb/E1BK68/entry#E1BK68-1", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAFPLAPEPAALLAVPGARREVFESTSFQGKEQAVGQSSAAPHLLHHHHHHAPLAHFPGDLVPAGLPCEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGAGAGPSTRAPGRMREHHAGPAMPSTYAVSRHGSSPSTGASSRIPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRVQAANGGSERAQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSEVPRPGPAMAGPVSSCRLSARPEGGSGRGRRAERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPMRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGC", "length": 863, "header": "tr|E1BK68-1|E1BK68_BOVIN Isoform 1 of F-box only protein 41 OS=Bos taurus OX=9913 GN=FBXO41 PE=4 SV=1 CANONICAL=E1BK68-1" }, "locus": { "chromosome": "11", "start_pos": 11191869, "end_pos": 11181056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016959.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016959.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016959.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016959.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 342, "start_aa": "Thr", "end_pos": 342, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr342", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536077", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536077", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A8K9-1", "protein_name": "F-box only protein 41", "gene_name": "FBXO41", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDSAAAAAAAAAASGFQLAPEPAALLAVPGARREVFESTSFQGKEQATGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGSCSGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGAGGSGAGPGTRGPGRSREHHAGPAVPSTYAVSRHGSSPSTGASSRIPAASQSSGCYDSDSLELPRPEEGTPEDSGPGGLGTRVQAANGGSDRAQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSDAPRPGPAVAGPLSSCRLSARPEGGSGRGRRAERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHVKVEGGC", "length": 874 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z656-1", "protein_name": "F-box only protein 41", "gene_name": "FBXO41", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYNHTYETLYVLSKTNSICDAAVFPLAADGALLTPAARRDYFESTSFQGKEQRFSCDLVPAEELEPAPSSSPSPRYVHEIEIPLTEIFTRGKAVAPAPTPPAAMDAAYEEGLARLKIRAFEKLEVDKRLEKLTEEVEQKIASQVGRLQVELDRKSSELEKAKQESLRLSREKQELEDRASELSRQVDVSVEMLASLKQDLVQKEQELTRKQQEVLQIDQFLKETAAREANAKVRLQHFIEELLDRADRAEKQLQIISSSCGTTPNGSLGRCGTPGAKAAGRPVPTRAQRERHPGLGAAVHGPYAIPNQRSSSSTGASSRAKAVSQSSGCYDSDSAEPCPTDDTADGHPYTARDGGRGSGLRRQAIQNWHRRPYRNSTEGEEGDVSDVGSRTTESEAEGWEPEVPGIAASRPGGSCRLTARSEGAMSKGGRLERGSPGHSSEVISPEILKMRAALFCIFTYLDTKTLLRAAEVCKDWKFVARHPAVWTRVLLENARVSSKFLAMLSQWCTQMHSLTLQNLKPRQRGKKESKEDYMKSTRGCLEAGLESLLKATGSNLLILRISHCPNVLTDRSLWLASCYCRALQAVTYRSSTDPVGHEVIWALGAGCRDIISLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGIGGAGCGVQGLASLARNCMRLQVLELDHVAEINQEVAAEMCREGLKGLEMLVLTSTPVTPKALLHFNSVCRNLKSIVVQVGIVDYFKEPHSPEAKKMFEEMVNKLQALRKRPGFSKILHIKVEGGC", "length": 801 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M8C7-1", "protein_name": "F-box only protein 41", "gene_name": "Fbxo41", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPAPAGPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCSGPTSASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGSASGPGLRGPGRMREHHAGPAVPSTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRQEEGPSEDSGPGGLGSRAQATNGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSDVPRPGPAVAGPLNSCRLSARPEGGSGRGRRMERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCRDIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC", "length": 873 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F6NUQ2-1", "protein_name": "F-box only protein 41", "gene_name": "fbxo41", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYNHTYETLYVLSKSNSVCDAAALLPLVADGALTAESRFPYRELPCSGEELGLAPSSTACYLPNVEFPLGEILVKTAMSSSDALSSAGNNAVAVAANVAASAVEAAYEEGLARLKARAFERLELDERLEKLSEEVEQKISARVSRLQAELERKSSELEKAKLESERLSQEKQDLEDKATELSRQVDVSVEMLASLKQDLVNKEQELSHKQQEVSQIDQFLQETAAREANAKLRLQQFIEELLDRADRAEKQLQIISNCGTTPNGSLGHCSLGSKSNGRQRNSSLSGVSRGMYQVSDRRSSPSTAASVRGKSVSQGSGGYDSDSVDLHALEDCPDAQYYHVQCRLGEGGGAGYERAAASRSWGLRKQAIQNWQRRPYRNSMEGEEGDVSDVGSRTTESEAEMWEQDRRADSSQHAGHRGGYRLPTGRSEGGYKACRHEKSPSKGSEVISPEVLKMRAALFCIFTYLDTKTLLRAAEVCRDWRSVARHPAVWTRVLLENARICSKFLCTLSQWCTQTHSLILQNLKPRQRGKKETKEEYLKSTRGCLEEGLEALLKGTGSNLLILKVSHCPNLLTDRSLWLASCYCRALQAVTYRSATDPVGQEVIWALGAGCRDIISLQVAPLHPCQQPARFSNRCLQTIGRCWPHLRALGVGGAGCGIQGLASLARNCMRLQVLELDHVSEINQEVAAEMCREGLKGLEMLVLTSTPVTPKALLHFNSVCRNLKSIVVQIGIEDYFEDPNSPEARKLFDEMVNKLQALKKRPGFSKILHVKADGLC", "length": 805 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6NS60-1", "protein_name": "F-box only protein 41", "gene_name": "Fbxo41", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQATGPSPAGPHLLHHHHHHAPLAHFPADLVPASLPCEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCSGPSSASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGSASGPGVRGPGRMREHHAGSAVPSTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGPSEDSGPGGLGSRAQATNGGSERSQAPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSDVPRPGPAVAGPLNSCRLSARPEGGSGRGRRVERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCRDIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC", "length": 873 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TF61-1", "protein_name": "F-box only protein 41", "gene_name": "FBXO41", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC", "length": 875 }, "evidence": [ { "id": "E1BK68", "url": "https://omabrowser.org/oma/group/E1BK68/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 863, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK68" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BK68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK68" }, { "id": "PF12937", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 546, "end_pos": 583, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BK68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK68" }, { "id": "PF23165", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23165" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FBX41/ZN365 C2H2-type zinc finger", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 35, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 342 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BK78-1", "uniprot_ac": "E1BK78", "uniprot_id": "E1BK78_BOVIN", "mass": { "chemical_mass": 25175.0, "monoisotopic_mass": 25175.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "RRM domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BK78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK78/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BK78", "url": "https://www.uniprot.org/uniprotkb/E1BK78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BK78", "locus": {} } ], "crossref": [ { "id": "E1BK78", "url": "https://alphafold.ebi.ac.uk/entry/E1BK78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35968:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35968:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BK78", "url": "https://www.uniprot.org/uniprotkb/E1BK78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK78-1", "url": "https://www.uniprot.org/uniprotkb/E1BK78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQVELKLPLLEKPKTPKNYSHPEVLHRTFETLSNLHKLLPNHLMELLHSCKSEEDKKKCENSEFSGLERILERHQFPREINLTPKPSSMPLWRRRQNNNANQGWKTCRLWGKNTKDPPTSTIVVRWLKKNMQPTEDLASVTHRLSVFGPIESVTLCGRQSAVVVFKHMVSACNAVSAFQSRAPGSMFQCAWQQRFMSREPSELRLSGQEACDGIHAFV", "length": 219, "header": "tr|E1BK78-1|E1BK78_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BK78-1" }, "isoforms": [ { "isoform_ac": "E1BK78-1", "url": "https://www.uniprot.org/uniprotkb/E1BK78/entry#E1BK78-1", "sequence": { "sequence": "MTQVELKLPLLEKPKTPKNYSHPEVLHRTFETLSNLHKLLPNHLMELLHSCKSEEDKKKCENSEFSGLERILERHQFPREINLTPKPSSMPLWRRRQNNNANQGWKTCRLWGKNTKDPPTSTIVVRWLKKNMQPTEDLASVTHRLSVFGPIESVTLCGRQSAVVVFKHMVSACNAVSAFQSRAPGSMFQCAWQQRFMSREPSELRLSGQEACDGIHAFV", "length": 219, "header": "tr|E1BK78-1|E1BK78_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BK78-1" }, "locus": { "chromosome": "23", "start_pos": 50064249, "end_pos": 50056953, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020193.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020193.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020193.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020193.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "E1BK78", "url": "https://www.uniprot.org/uniprotkb/E1BK78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BK78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BK78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BK78" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKA4-1", "uniprot_ac": "E1BKA4", "uniprot_id": "E1BKA4_BOVIN", "mass": { "chemical_mass": 42136.0, "monoisotopic_mass": 42136.0 }, "refseq": { "ac": "NP_001193119", "name": "HAUS augmin-like complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193119" }, "gene_names": [ { "name": "HAUS4", "type": "recommended", "evidence": [ { "id": "E1BKA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ] }, { "name": "HAUS4", "type": "synonym", "evidence": [ { "id": "NP_001193119", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193119" } ] } ], "protein_names": [ { "name": "HAUS augmin like complex subunit 4", "type": "synonym", "evidence": [ { "id": "E1BKA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA4/entry#names_and_taxonomy" } ] }, { "name": "HAUS augmin-like complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001193119", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193119" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAUS4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4", "locus": { "chromosome": "10", "start_pos": 21896197, "end_pos": 21888397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012723", "url": "https://www.ensembl.org/id/ENSBTAG00000012723" } ] } } ], "crossref": [ { "id": "E1BKA4", "url": "https://alphafold.ebi.ac.uk/entry/E1BKA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012723", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012723", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614307", "url": "https://www.ncbi.nlm.nih.gov/gene/614307", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614307", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614307", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWALKEF", "url": "https://omabrowser.org/oma/group/NWALKEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKA4", "url": "https://www.orthodb.org/?gene=E1BKA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16219:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16219:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14735", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193119", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGDFCSPGEGMEMLQQVCSKQLPPCNLSEEDLLQNPHFSQLLLSLSQHVDESGLSLTLAKEQAQAWKDVRLHKTTWLRSEILQRVIQELLVDYYVKTQDADLTSEDRKFHETLEQRLLVTELTRLLGPSQEREVPPLLGLEKADLLELMPPSEDFVYMRARLPLEVEEQLKKKCFTVLCYHNPSSDLDSETLKAAKVWNLAEVLAGEKQQCQAAKSQQEEQMVLLEKKSATYSQVLLRCLALLQRLLQEHRLKTQSELDRINAQYLEIKCSAMILKLRMEELKILSDTYTAEKVEVHRLIRDRLEGAIRLQEQDMEKSRQVLNTYEVLGEEFDKLVKEYTQLKQATENKRWTLQEFNKACR", "length": 363, "header": "tr|E1BKA4-1|E1BKA4_BOVIN Isoform 1 of HAUS augmin like complex subunit 4 OS=Bos taurus OX=9913 GN=HAUS4 PE=4 SV=2 CANONICAL=E1BKA4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTL5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKA4/entry#A0A3Q1MTL5-1", "sequence": { "sequence": "MASGDFCSPGEGMEMLQQVCSKQLPPCNLSEEDLLQNPHFSQLLLSLSQHVDESGLSLTLAKEQAQAWKDVRLHKTTWLRSEILQRVIQELLVDYYVKTQDADLTSEDRKDFVYMRARLPLEVEEQLKKKCFTVLCYHNPSSDLDSETLKAAKVWNLAEVLAGEKQQCQAAKSQQEEQMVLLEKKSATYSQVLLRCLALLQRLLQEHRLKTQSELDRINAQYLEIKCSAMILKLRMEELKILSDTYTAEKVEVHRLIRDRLEGAIRLQEQDMEKSRQVLNTYEVLGEEFDKLVKEYTQLKQATENKRWTLQEFNKACR", "length": 318, "header": "tr|A0A3Q1MTL5-1|A0A3Q1MTL5_BOVIN Computationally mapped isoform of HAUS augmin like complex subunit 4 OS=Bos taurus OX=9913 GN=HAUS4 PE=4 SV=1 CANONICAL=E1BKA4-1" }, "locus": { "chromosome": "10", "start_pos": 21895900, "end_pos": 21888791, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080337.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080337.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058014.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058014.2" } ] } }, { "isoform_ac": "A0AAA9SL79-1", "url": "https://www.uniprot.org/uniprotkb/E1BKA4/entry#A0AAA9SL79-1", "sequence": { "sequence": "MASGDFCSPGEGMEMLQQVCSKQLPPCNLSEEDLLQNPHFSQLLLSLSQHVDESGLSLTLAKEQAQAWKDVRLHKTTWLRSEILQRVIQELLVDYYVKTQDADLTSEDRKVLLRCLALLQRLLQEHRLKTQSELDRINAQYLEIKCSAMILKLRMEELKILSDTYTAEKVEVHRLIRDRLEGAIRLQEQDMEKSRQVLNTYEVLGEEFDKLVKEYTQLKQATENKRWTLQEFNKACR", "length": 237, "header": "tr|A0AAA9SL79-1|A0AAA9SL79_BOVIN Computationally mapped isoform of HAUS augmin like complex subunit 4 OS=Bos taurus OX=9913 GN=HAUS4 PE=4 SV=1 CANONICAL=E1BKA4-1" }, "locus": { "chromosome": "10", "start_pos": 21895900, "end_pos": 21888791, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100183.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100183.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087130.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087130.1" } ] } }, { "isoform_ac": "E1BKA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKA4/entry#E1BKA4-1", "sequence": { "sequence": "MASGDFCSPGEGMEMLQQVCSKQLPPCNLSEEDLLQNPHFSQLLLSLSQHVDESGLSLTLAKEQAQAWKDVRLHKTTWLRSEILQRVIQELLVDYYVKTQDADLTSEDRKFHETLEQRLLVTELTRLLGPSQEREVPPLLGLEKADLLELMPPSEDFVYMRARLPLEVEEQLKKKCFTVLCYHNPSSDLDSETLKAAKVWNLAEVLAGEKQQCQAAKSQQEEQMVLLEKKSATYSQVLLRCLALLQRLLQEHRLKTQSELDRINAQYLEIKCSAMILKLRMEELKILSDTYTAEKVEVHRLIRDRLEGAIRLQEQDMEKSRQVLNTYEVLGEEFDKLVKEYTQLKQATENKRWTLQEFNKACR", "length": 363, "header": "tr|E1BKA4-1|E1BKA4_BOVIN Isoform 1 of HAUS augmin like complex subunit 4 OS=Bos taurus OX=9913 GN=HAUS4 PE=4 SV=2 CANONICAL=E1BKA4-1" }, "locus": { "chromosome": "10", "start_pos": 21895900, "end_pos": 21888791, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016912.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016912.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016912.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016912.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614307", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614307", "resource": "KEGG Pathway" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJK0-1", "protein_name": "HAUS augmin like complex subunit 4", "gene_name": "HAUS4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASGDFCSPGEGMELLQQVCSKQLPPCHLREEDLLQNPHFSKLLLSLSQHMDECGLSLILAKEQTQAWKEVRLHKTKWLRFEILHRVIQELLVDYYVKIQDTNLTSEDKKFHETLEQRLLVTELTQLLGPRQETEVPSLLGLEKSDLLELMPPSEDCVWMRARLALEVEELLKKKCFTLLCYHNPDSDSDGETRKAEKVGKLAEVLMDEKQQCQDAKSQQKEQMVLLEKKSATYSQVLLRCLALLQRLLQEHRLKAQSELDRSNAQYLEIKCSTLILKLRIEELKILSDTYTAEKVEVHRLIRDRLEGAIHLQEQDMEKSRQVLNTYEVLGEEFDRLVKEYTQLKQATENKRWALQEFDKAYR", "length": 363 }, "evidence": [ { "id": "E1BKA4", "url": "https://omabrowser.org/oma/group/E1BKA4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AYC0-1", "protein_name": "HAUS augmin-like complex, subunit 4", "gene_name": "Haus4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGDFCSPGEGVEILQQVCDKQFPPCALTEEDLIQNPYFSKLLLSLSQHVDESGLSLPLAKEQAQAWSEVRLRKTAWLRYEILQRVIQELLVDYYVKAQDTNLTSEDKKFHETLEQRLLVTELTQLSGPGREKEMPPLLGLEKADLLELMPPSQDFVWMKARLQQEVEEQLKRKCFSLLCYHDPSSDTDGDKLKAAKVWTLTEVLVREKQQCMEAKGQQKEQLVLLEKKRTTYSQVLLRCLSLLQRLLQEHRLKTQSELDRINTQYLEIKCSAMILKMRMEELKILSDTYSAEKVEVHRLIRDHLEGAIRLQEQDMEKSRLALHTYEVLGEDFENLVKEYTQLKLAAENKRWALQEFSKAYR", "length": 363 }, "evidence": [ { "id": "E1BKA4", "url": "https://omabrowser.org/oma/group/E1BKA4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BFT2-1", "protein_name": "HAUS augmin-like complex subunit 4", "gene_name": "Haus4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGDFCAPGEGVEMLLQVCGKQFPPCALTEEDLIQNPRFSKLLLSLSQHVDESGLSLTLAKEQAQAWSEVRHRKTAWLRYEILQRVIQELLVDYYVKAQDTNLTSEDKKFHETLEQRLLVTELTQLSGPGQETELPPLLGLERTDLLELMPPSQDFVWMKARLQLEVEEQLKRKCFTLLCYHDPSSDTDGDTLKAAKVWTLTEVLVREKQQCLEAKSQQKEQLVLLEKKRTTYSQVLLRCLALLQRLLQEHRLQTKSELDRINAQYLELKCSAMILRLRMEELKVLSDTYSAEKVEMHRLIRDRLEGAIRLQEQDLEKSRLVLHTYEALGEDFESLVREYTQLRLAADNKRWALQELSKAQR", "length": 363 }, "evidence": [ { "id": "E1BKA4", "url": "https://omabrowser.org/oma/group/E1BKA4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6D7-1", "protein_name": "HAUS augmin-like complex subunit 4", "gene_name": "HAUS4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGDFCSPGEGMEILQQVCSKQLPPCNLSKEDLLQNPYFSKLLLNLSQHVDESGLSLTLAKEQAQAWKEVRLHKTTWLRSEILHRVIQELLVDYYVKIQDTNVTSEDKKFHETLEQRLLVTELMRLLGPSQEREIPPLLGLEKADLLELMPLSEDFVWMRARLQQEVEEQLKKKCFTLLCYYDPNSDADSETVKAAKVWKLAEVLVGEQQQCQDAKSQQKEQMLLLEKKSAAYSQVLLRCLTLLQRLLQEHRLKTQSELDRINAQYLEVKCGAMILKLRMEELKILSDTYTVEKVEVHRLIRDRLEGAIHLQEQDMENSRQVLNSYEVLGEEFDRLVKEYTVLKQATENKRWALQEFSKVYR", "length": 363 }, "evidence": [ { "id": "E1BKA4", "url": "https://omabrowser.org/oma/group/E1BKA4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" }, { "name": "HAUS complex", "id": "GO:0070652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070652", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" }, { "name": "mitotic spindle microtubule", "id": "GO:1990498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "centrosome cycle", "id": "GO:0007098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007098", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" }, { "name": "spindle assembly", "id": "GO:0051225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule minus-end binding", "id": "GO:0051011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051011", "evidence": [ { "database": "UniProtKB", "id": "E1BKA4", "url": "https://www.uniprot.org/uniprotkb/E1BKA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 363, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKA4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 28, "end_pos": 30 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKB0-1", "uniprot_ac": "E1BKB0", "uniprot_id": "E1BKB0_BOVIN", "mass": { "chemical_mass": 27939.0, "monoisotopic_mass": 27939.0 }, "refseq": { "ac": "XP_002687852", "name": "C-type lectin domain family 9 member A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687852" }, "gene_names": [ { "name": "CLEC9A", "type": "recommended", "evidence": [ { "id": "E1BKB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ] }, { "name": "CLEC9A", "type": "synonym", "evidence": [ { "id": "XP_002687852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687852" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 9 member A", "type": "recommended", "evidence": [ { "id": "E1BKB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB0/entry#names_and_taxonomy" } ] }, { "name": "C-type lectin domain family 9 member A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687852" } ] } ], "function": [ { "annotation": "Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0#function" }, { "database": "UniProtKB", "id": "ARBA00058175", "url": "https://www.uniprot.org/uniprotkb/ARBA00058175#function" }, { "database": "UniProtKB", "id": "A0A3Q1NBI6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBI6#function" }, { "database": "UniProtKB", "id": "A0AAA9SX48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX48#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC9A", "url": "https://www.uniprot.org/uniprotkb/E1BKB0", "locus": { "chromosome": "5", "start_pos": 99886583, "end_pos": 99900926, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009537", "url": "https://www.ensembl.org/id/ENSBTAG00000009537" } ] } } ], "crossref": [ { "id": "E1BKB0", "url": "https://alphafold.ebi.ac.uk/entry/E1BKB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009537", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009537", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616060", "url": "https://www.ncbi.nlm.nih.gov/gene/616060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDSPAPN", "url": "https://omabrowser.org/oma/group/WDSPAPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NBI6", "url": "https://www.orthodb.org/?gene=A0A3Q1NBI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKB0", "url": "https://www.orthodb.org/?gene=E1BKB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47727", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47727", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47727:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47727:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687852", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBI6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBI6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQEDEIYTSLQWDTPTSNPYQKHLSSTKNSGVWCLVMVILCIFCIGSLATSIFLGIKLFQMSTTIMKQQEKLIQQERALLNFTQWKRNPNLQMTYCQTLMQKSLSSAYNCSPCPDNWIQNGESCYHVFESWTFWHTSRKDCWKKGSDLLQIESKEEMDFITGSLKKIKRNYDYWVGLSQNGSNQPWLWQDGSSPSADLLPRQGPQSTNQVCGYLRDNDLSSANCSVWKYFICEKYALRSST", "length": 241, "header": "tr|E1BKB0-1|E1BKB0_BOVIN Isoform 1 of C-type lectin domain family 9 member A OS=Bos taurus OX=9913 GN=CLEC9A PE=4 SV=3 CANONICAL=E1BKB0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NBI6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB0/entry#A0A3Q1NBI6-1", "sequence": { "sequence": "MQEDEIYTSLQWDTPTSNPYQKHLSSTKNSGVWCLVMVILCIFCIGSLATSIFLGIKSYNCSPCPDNWIQNGESCYHVFESWTFWHTSRKDCWKKGSDLLQIESKEEMDFITGSLKKIKRNYDYWVGLSQNGSNQPWLWQDGSSPSADLLPRQGPQSTNQVCGYLRDNDLSSANCSVWKYFICEKYALRSST", "length": 192, "header": "tr|A0A3Q1NBI6-1|A0A3Q1NBI6_BOVIN Computationally mapped isoform of C-type lectin domain family 9 member A OS=Bos taurus OX=9913 GN=CLEC9A PE=4 SV=2 CANONICAL=E1BKB0-1" }, "locus": { "chromosome": "5", "start_pos": 99899305, "end_pos": 99887561, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078371.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078371.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068683.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068683.2" } ] } }, { "isoform_ac": "A0AAA9SX48-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB0/entry#A0AAA9SX48-1", "sequence": { "sequence": "MFSQGCEKLTNFSSCINLLLTTKGEFVSAFHVDCLIHQSIPDMQEDEIYTSLQWDTPTSNPYQKHLSSTKNSGVWCLVMVILCIFCIGSLATSIFLGIKLFQMSTTIMKQQEKLIQQERALLNFTQWKRNPNLQMTYCQTLMQKSLSSAYNCSPCPDNWIQNGESCYHVFESWTFWHTSRKDCWKKGSDLLQIESKEEMDFITGSLKKIKRNYDYWVGLSQNGSNQPWLWQDGSSPSADLLPRQGPQSTNQVCGYLRDNDLSSANCSVWKYFICEKYALRSST", "length": 283, "header": "tr|A0AAA9SX48-1|A0AAA9SX48_BOVIN Computationally mapped isoform of C-type lectin domain family 9 member A OS=Bos taurus OX=9913 GN=CLEC9A PE=4 SV=1 CANONICAL=E1BKB0-1" }, "locus": { "chromosome": "5", "start_pos": 99899431, "end_pos": 99887561, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126461.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126461.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087857.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087857.1" } ] } }, { "isoform_ac": "E1BKB0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB0/entry#E1BKB0-1", "sequence": { "sequence": "MQEDEIYTSLQWDTPTSNPYQKHLSSTKNSGVWCLVMVILCIFCIGSLATSIFLGIKLFQMSTTIMKQQEKLIQQERALLNFTQWKRNPNLQMTYCQTLMQKSLSSAYNCSPCPDNWIQNGESCYHVFESWTFWHTSRKDCWKKGSDLLQIESKEEMDFITGSLKKIKRNYDYWVGLSQNGSNQPWLWQDGSSPSADLLPRQGPQSTNQVCGYLRDNDLSSANCSVWKYFICEKYALRSST", "length": 241, "header": "tr|E1BKB0-1|E1BKB0_BOVIN Isoform 1 of C-type lectin domain family 9 member A OS=Bos taurus OX=9913 GN=CLEC9A PE=4 SV=3 CANONICAL=E1BKB0-1" }, "locus": { "chromosome": "5", "start_pos": 99899305, "end_pos": 99887561, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012546.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012546.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012546.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012546.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616060", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I259-1", "protein_name": "C-type lectin domain family 9 member A isoform X1", "gene_name": "Clec9a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHEEEIYCSLQWDSPPEEGSQKCLSPCKCSGTWCVVTVISCVFCVGLLATSIFLGIKFFQVSSLAMNQQERLIQQDKQLLNLTQWQRNYTLQMKNCQALQQRSPRSGSNCSPCPHNWIQNGRSCYYFFQIWEIWNRSKENCLKEGASLLQIDSKEEMDFLIQSLWKFKDGYWVGVYHDEPSRSWFWLDGSSPLSDLLPTERQLPSSQICGYLKDQSLFSDNCSSWKYFICEKNALGSCI", "length": 239 }, "evidence": [ { "id": "E1BKB0", "url": "https://omabrowser.org/oma/group/E1BKB0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AD02-1", "protein_name": "C-type lectin domain family 9 member A", "gene_name": "Clec9a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHEEEIYTSLQWDIPTSEASQKCPSLSKCPGTWCIVTVISCVVCVGLLAASIFLGIKFSQVSSLVMEQRERLIRQDTALLNLTEWQRNHTLQLKSCQASLQRSLRSGSNCNPCPPNWIQNGKSCYYAFDRWETWNNSKKSCLKEGDSLLQIDSKEEMEFINLSIWKLKGGYEYWVGVFQDGPSGSWFWEDGSSPLSDLLPTDRQLSASQICGYLKDHTLISDNCSNWKYFICEKKAFGSCI", "length": 241 }, "evidence": [ { "id": "E1BKB0", "url": "https://omabrowser.org/oma/group/E1BKB0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UXN8-1", "protein_name": "C-type lectin domain family 9 member A", "gene_name": "CLEC9A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV", "length": 241 }, "evidence": [ { "id": "E1BKB0", "url": "https://omabrowser.org/oma/group/E1BKB0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BRU4-1", "protein_name": "C-type lectin domain family 9 member A", "gene_name": "Clec9a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHAEEIYTSLQWDIPTSEASQKCQSPSKCSGAWCVVTMISCVVCMGLLATSIFLGIKFFQVSSLVLEQQERLIQQDTALVNLTQWQRKYTLEYCQALLQRSLHSGSDCSPCPHNWIQNGKSCYYVFERWEMWNISKKSCLKEGASLFQIDSKEEMEFISSIGKLKGGNKYWVGVFQDGISGSWFWEDGSSPLSDLLPAERQRSAGQICGYLKDSTLISDKCDSWKYFICEKKAFGSCI", "length": 238 }, "evidence": [ { "id": "E1BKB0", "url": "https://omabrowser.org/oma/group/E1BKB0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "E1BKB0", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKB0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKB0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKB0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB0" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 233, "start_aa": "Asn", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 223, "end_pos": 225 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKB3-1", "uniprot_ac": "E1BKB3", "uniprot_id": "E1BKB3_BOVIN", "mass": { "chemical_mass": 73284.0, "monoisotopic_mass": 73284.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF568", "type": "recommended", "evidence": [ { "id": "E1BKB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ] } ], "protein_names": [ { "name": "Zinc finger protein 568", "type": "synonym", "evidence": [ { "id": "E1BKB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF568", "url": "https://www.uniprot.org/uniprotkb/E1BKB3", "locus": { "chromosome": "18", "start_pos": 47152340, "end_pos": 47213090, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021742", "url": "https://www.ensembl.org/id/ENSBTAG00000021742" } ] } } ], "crossref": [ { "id": "E1BKB3", "url": "https://alphafold.ebi.ac.uk/entry/E1BKB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021742", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021742", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000048389", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048389", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV40", "url": "https://www.orthodb.org/?gene=A0A3Q1LV40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232:SF163", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232:SF163", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF460", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF460", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LV40", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV40-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYS3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYS3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRLTRMMERTAWHSPDSALFQEEEDMASSLETVTFKDVAVDLTQEEWQQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEHEEEPWVVEEEMLGRHCPEVWKVDEQIKKQQETLVRNVTSISKKTLIKENAVEYKNVAKVFPLDSDIVTSRQKFFECDSLDKDFEHSLDLFSYEKGFIKKKSYECNKYGKPFYHCSSHVITPFKCNQCGQDFSHRFDLIRHERSHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHQRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKAFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVNLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECNECGKAFSRKENLITHQKIHTGEKPYECNECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRIHTGEKPYECNECGKAFSQRASLSIHKRGHTGEKRRVY", "length": 632, "header": "tr|E1BKB3-1|E1BKB3_BOVIN Isoform 1 of Zinc finger protein 568 OS=Bos taurus OX=9913 GN=ZNF568 PE=3 SV=4 CANONICAL=E1BKB3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV40-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#A0A3Q1LV40-1", "sequence": { "sequence": "MLENYNNLISLGFTNFKPDVISLLEQRKEPWMVKGKETEEWCPDWKSRREAKTLSLKEDSYEIKSLQLERVRYTREVRCHLERLPKEHFRQAIITFEERSTSIQHTDPRAPQTAPTGAKSCESKECRTSRSPHQSQHERSHNKEKDSKCGECEKAFNSRSDLMKHQRIHESQKSNENKEGDFIHDSQMMRSQSINTAEKPHKCKECGKAFHSTSQLSKHQKIHIGEKPFTCTECGKAFPSTSQLNLHQRIHTNEKYYECKECGKAFTRPSHLLRHQRIHTGEKPHKCKDCGKAFRYDIQLSLHQIIHTGERRYECKECGKVYSCASQLNLHQRIHTGEKPHKCREWGKGFISDSHLVRHQSVHTGEKPYKCKQCGKDIRELTRHQRAHMGEKPYKCKECEMAFTCSTELIRHQKIHAGERPHKCKECGKAFIQRSELTHHERNHSGEKPYECKECGKAFGRGSELSR", "length": 467, "header": "tr|A0A3Q1LV40-1|A0A3Q1LV40_BOVIN Computationally mapped isoform of Zinc finger protein 568 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1BKB3-1" }, "locus": { "chromosome": "18", "start_pos": 47158711, "end_pos": 47152340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077096.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077096.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061052.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061052.2" } ] } }, { "isoform_ac": "A0AAA9SXH9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#A0AAA9SXH9-1", "sequence": { "sequence": "MKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEHEEEPWVVEEEMLGRHCPGSRRGEEKSCCASKVMVEEDFRFKDVVIYFSWKEWECLHSAQKDLYQDVMLENYNNLISLGFTNFKPDVISLLEQRKEPWMVKGKETEEWCPDWKSRREAKTLSLKEDSYEIKSLQLERVRYTREVRCHLERLPKEHFRQAIITFEERSTSIQHTDPRAPQTAPTGAKSCESKECRTSRSPHQSQHERSHNKEKDSKCGECEKAFNSRSDLMKHQRIHESQKSNENKEGDFIHDSQMMRSQSINTAEKPHKCKECGKAFHSTSQLSKHQKIHIGEKPFTCTECGKAFPSTSQLNLHQRIHTNEKYYECKECGKAFTRPSHLLRHQRIHTGEKPHKCKDCGKAFRYDIQLSLHQIIHTGERRYECKECGKVYSCASQLNLHQRIHTGEKPHKCREWGKGFISDSHLVRHQSVHTGEKPYKCKQCGKDIRELTRHQRAHMGEKPYKCKECEMAFTCSTELIRHQKIHAGERPHKCKECGKAFIQRSELTHHERNHSGEKPYECKECGKAFGRGSELSR", "length": 571, "header": "tr|A0AAA9SXH9-1|A0AAA9SXH9_BOVIN Computationally mapped isoform of Zinc finger protein 568 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BKB3-1" }, "locus": { "chromosome": "18", "start_pos": 47196464, "end_pos": 47152340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090062.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090062.1" } ] } }, { "isoform_ac": "A0AAA9TLP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#A0AAA9TLP4-1", "sequence": { "sequence": "STSPSEINSSSVTMKRLTRMMERTAWHSPDSALFQEEEDMASSLETVTFKDVAVDLTQEEWQQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEHEEEPWVVEEEMLGRHCPDDNMMSLKTQEIQLQQT", "length": 135, "header": "tr|A0AAA9TLP4-1|A0AAA9TLP4_BOVIN Computationally mapped isoform of Zinc finger protein 568 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=E1BKB3-1" }, "locus": { "chromosome": "18", "start_pos": 47212893, "end_pos": 47194599, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127649.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127649.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098140.1" } ] } }, { "isoform_ac": "A0ABI0NYS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#A0ABI0NYS3-1", "sequence": { "sequence": "MGSQLLQIVFTQVNGRAASWGKLFTCPITGVHGPSQRETVTFKDVAVDLTQEEWQQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEHEEEPWVVEEEMLGRHCPEVWKVDEQIKKQQETLVRNVTSISKKTLIKENAVEYKNVAKVFPLDSDIVTSRQKFFECDSLDKDFEHSLDLFSYEKGFIKKKSYECNKYGKPFYHCSSHVITPFKCNQCGQDFSHRFDLIRHERSHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHQRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKAFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVNLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECNECGKAFSRKENLITHQKIHTGEKPYECNECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRIHTGEKPYECNECGKAFSQRASLSIHKRGHTGEKRRVY", "length": 638, "header": "tr|A0ABI0NYS3-1|A0ABI0NYS3_BOVIN Computationally mapped isoform of Zinc finger protein 568 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1BKB3-1" }, "locus": { "chromosome": "18", "start_pos": 47198492, "end_pos": 47191219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146530.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146530.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106642.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106642.1" } ] } }, { "isoform_ac": "E1BKB3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB3/entry#E1BKB3-1", "sequence": { "sequence": "MKRLTRMMERTAWHSPDSALFQEEEDMASSLETVTFKDVAVDLTQEEWQQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEHEEEPWVVEEEMLGRHCPEVWKVDEQIKKQQETLVRNVTSISKKTLIKENAVEYKNVAKVFPLDSDIVTSRQKFFECDSLDKDFEHSLDLFSYEKGFIKKKSYECNKYGKPFYHCSSHVITPFKCNQCGQDFSHRFDLIRHERSHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHQRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKAFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVNLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECNECGKAFSRKENLITHQKIHTGEKPYECNECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRIHTGEKPYECNECGKAFSQRASLSIHKRGHTGEKRRVY", "length": 632, "header": "tr|E1BKB3-1|E1BKB3_BOVIN Isoform 1 of Zinc finger protein 568 OS=Bos taurus OX=9913 GN=ZNF568 PE=3 SV=4 CANONICAL=E1BKB3-1" }, "locus": { "chromosome": "18", "start_pos": 47212851, "end_pos": 47191219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032175.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032175.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032113.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032113.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "E1BKB3", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 427, "end_pos": 429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKB3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 632, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKB3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKB3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 210, "end_pos": 237, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKB3" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 105, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 427, "end_pos": 429 }, { "start_pos": 504, "end_pos": 506 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKE0-1", "uniprot_ac": "E1BKE0", "uniprot_id": "E1BKE0_BOVIN", "mass": { "chemical_mass": 14404.0, "monoisotopic_mass": 14404.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BKE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKE0", "url": "https://www.uniprot.org/uniprotkb/E1BKE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BKE0", "locus": {} } ], "crossref": [ { "id": "E1BKE0", "url": "https://alphafold.ebi.ac.uk/entry/E1BKE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051786", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051786", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268:SF101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268:SF101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BKE0", "url": "https://www.uniprot.org/uniprotkb/E1BKE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DSGVTQTPKYLIKSRKQQATLRCSPNSGHSSVNWYQQALGQGPQFLVQCYRGQVSRGENMPDRFSAKQFSDLRSELNLSSLELTDSAVYLCASSQDTALHDQVPLGQKHSYPSSGSGLEGVGCQPARPRLW", "length": 131, "header": "tr|E1BKE0-1|E1BKE0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=E1BKE0-1" }, "isoforms": [ { "isoform_ac": "E1BKE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE0/entry#E1BKE0-1", "sequence": { "sequence": "DSGVTQTPKYLIKSRKQQATLRCSPNSGHSSVNWYQQALGQGPQFLVQCYRGQVSRGENMPDRFSAKQFSDLRSELNLSSLELTDSAVYLCASSQDTALHDQVPLGQKHSYPSSGSGLEGVGCQPARPRLW", "length": 131, "header": "tr|E1BKE0-1|E1BKE0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=E1BKE0-1" }, "locus": { "chromosome": "4", "start_pos": 105589235, "end_pos": 105588843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056258.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056258.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047658.5", "url": "https://www.ensembl.org/id/ENSBTAP00000047658.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BKE0", "url": "https://www.uniprot.org/uniprotkb/E1BKE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1BKE0", "url": "https://www.uniprot.org/uniprotkb/E1BKE0" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "E1BKE0", "url": "https://www.uniprot.org/uniprotkb/E1BKE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 131, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKE0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 106, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKE5-1", "uniprot_ac": "E1BKE5", "uniprot_id": "E1BKE5_BOVIN", "mass": { "chemical_mass": 31447.0, "monoisotopic_mass": 31447.0 }, "refseq": { "ac": "NP_001178095", "name": "ankyrin repeat and SOCS box protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" }, "gene_names": [ { "name": "ASB9", "type": "recommended", "evidence": [ { "id": "E1BKE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ] }, { "name": "ASB9", "type": "synonym", "evidence": [ { "id": "NP_001178095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box containing 9", "type": "synonym", "evidence": [ { "id": "E1BKE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE5/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 9", "type": "synonym", "evidence": [ { "id": "NP_001178095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" } ] }, { "name": "ankyrin repeat and SOCS box-containing 9-like protein", "type": "synonym", "evidence": [ { "id": "NP_001178095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" } ] }, { "name": "ankyrin repeat/SOCS box-containing 9-like protein", "type": "synonym", "evidence": [ { "id": "NP_001178095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" } ] } ], "function": [ { "annotation": "Study results support a physiologically relevant role of ASB9 in the bovine ovulatory follicles by targeting specific proteins likely for degradation, contributing to reduced granulosa cells (GC) proliferation, and could be involved in the final GC differentiation into luteal cells. GeneRIF: The ovulation process is associated with LH/hCG-induced up-regulation of ASB9 mRNA and protein in granulosa cells of bovine preovulatory follicles. The study provides evidence that ASB9 reduces granulosa cells proliferation at the time of ovulation and could be involved in the final differentiation of granulosa cells into luteal cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001178095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" }, { "database": "PubMed", "id": "30811458", "url": "https://glygen.org/publication/PubMed/30811458" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB9", "url": "https://www.uniprot.org/uniprotkb/E1BKE5", "locus": { "chromosome": "X", "start_pos": 128246226, "end_pos": 128217622, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009198", "url": "https://www.ensembl.org/id/ENSBTAG00000009198" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009198", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009198", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "784390", "url": "https://www.ncbi.nlm.nih.gov/gene/784390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784390", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784390", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHHKITG", "url": "https://omabrowser.org/oma/group/QHHKITG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKE5", "url": "https://www.orthodb.org/?gene=E1BKE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24136:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24136:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZM5", "url": "https://www.uniprot.org/uniprotkb/G3MZM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZM5-1", "url": "https://www.uniprot.org/uniprotkb/G3MZM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGERPGRNGSKPPDMRLFSNPLMGDFVSDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVNQGRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPLEVVPPESPLIQLLQREGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLHI", "length": 287, "header": "tr|E1BKE5-1|E1BKE5_BOVIN Isoform 1 of Ankyrin repeat and SOCS box containing 9 OS=Bos taurus OX=9913 GN=ASB9 PE=3 SV=2 CANONICAL=E1BKE5-1" }, "isoforms": [ { "isoform_ac": "E1BKE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE5/entry#E1BKE5-1", "sequence": { "sequence": "MDGERPGRNGSKPPDMRLFSNPLMGDFVSDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVNQGRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPLEVVPPESPLIQLLQREGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLHI", "length": 287, "header": "tr|E1BKE5-1|E1BKE5_BOVIN Isoform 1 of Ankyrin repeat and SOCS box containing 9 OS=Bos taurus OX=9913 GN=ASB9 PE=3 SV=2 CANONICAL=E1BKE5-1" }, "locus": { "chromosome": "X", "start_pos": 128245724, "end_pos": 128217990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012118.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012118.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012118.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012118.5" } ] } }, { "isoform_ac": "G3MZM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE5/entry#G3MZM5-1", "sequence": { "sequence": "MEEEQRRQKGMKPCDGRGGGSKDTCDEPRNCKDGHPTPEARRDFVSDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVNQGRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPLEVVPPESPLIQLLQREGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLHI", "length": 304, "header": "tr|G3MZM5-1|G3MZM5_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box containing 9 OS=Bos taurus OX=9913 GN=ASB9 PE=3 SV=1 CANONICAL=E1BKE5-1" }, "locus": { "chromosome": "X", "start_pos": 128245724, "end_pos": 128221335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064207.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064207.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055026.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055026.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Gonadotropin regulation of ankyrin-repeat and SOCS-box protein 9 (ASB9) in ovarian follicles and identification of binding partners.", "journal": "PloS one", "date": "2019", "authors": "Benoit Gabriel, Warma Aly, Lussier Jacques G, Ndiaye Kalidou", "evidence": [ { "database": "RefSeq", "id": "NP_001178095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178095" } ], "reference": [ { "type": "PubMed", "id": "30811458", "url": "https://glygen.org/publication/PubMed/30811458" } ] } ], "pathway": [ { "id": "bta:784390", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784390", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H2Y9-1", "protein_name": "Ankyrin repeat and SOCS box protein 9", "gene_name": "Asb9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDGGRRSRLQRLGGCPHLRFLSNPLMGDIVSDWSPLHDAAIHGRLLTLRNLINQGWPVNIITADHVSPLHEACLRGHFSCASVLLSHGAQVNGIAIDWRTPLYNACLGGNHDCVTLLLDHGAAPHPESDLASPIHEAAKRGHVKCIESLADYGANIDYNISHLGTPLYIACKNQQLACAKKLLELGASVNKGKGLESPLHVVARMSFGELVYLLMDFGANVQARNAEGKRPVDLVPRESPVTEIFLEREGPESLMQLCRLRIRKCFGIRQHHKIAALFLPEDLKRFLLHL", "length": 290 }, "evidence": [ { "id": "E1BKE5", "url": "https://omabrowser.org/oma/group/E1BKE5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X2I0-1", "protein_name": "Ankyrin repeat and SOCS box containing 9", "gene_name": "ASB9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDEEGMNQNGSKSQGAGGQVPATTPAEVLMRDFVSDWSPLHDASIHGRLLALKKLINQGSDVNLVTADHVSPLHEACLGGHAACASFLLKHGAKVNGVTVDWHTPLFSACVSGSVACLNLLLQHGANLHPPCDLASPIHEAAKRGHVECVELLTSHGVNIDHNVKHLGTPLYVACENQQVDCARKLLESGANVNSGKGLESPLHAAARSCSVELVMLLIDFGADIWAKNAESKRPMELVPPGSPLGRLFLQKEGPLSLMQLCRLCIRRCFGHKQHQKITGLLLPEELKHFLLHV", "length": 294 }, "evidence": [ { "id": "E1BKE5", "url": "https://omabrowser.org/oma/group/E1BKE5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M6U5-1", "protein_name": "Ankyrin repeat and SOCS box-containing 9", "gene_name": "Asb9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDGEQGGRSDKPGGSPHLRFLSNPLMGDVVSDWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAPHPESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVNQGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDLVPLESPVIEIFLQREGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLHL", "length": 290 }, "evidence": [ { "id": "E1BKE5", "url": "https://omabrowser.org/oma/group/E1BKE5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91ZT8-1", "protein_name": "Ankyrin repeat and SOCS box protein 9", "gene_name": "Asb9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDGEQRGRSDRPGGSPHLPFLSNPLMGDVVSDWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPHPETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVNQGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDLVPLESPLIQIFLQNEGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL", "length": 290 }, "evidence": [ { "id": "E1BKE5", "url": "https://omabrowser.org/oma/group/E1BKE5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DX5-1", "protein_name": "Ankyrin repeat and SOCS box protein 9", "gene_name": "ASB9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL", "length": 294 }, "evidence": [ { "id": "E1BKE5", "url": "https://omabrowser.org/oma/group/E1BKE5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BKE5", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE5" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 238, "end_pos": 287, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BKE6-1", "uniprot_ac": "E1BKE6", "uniprot_id": "E1BKE6_BOVIN", "mass": { "chemical_mass": 52839.0, "monoisotopic_mass": 52839.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "E1BKE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BKE6", "locus": {} } ], "crossref": [ { "id": "E1BKE6", "url": "https://alphafold.ebi.ac.uk/entry/E1BKE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009197", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009197", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKE6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSEIPEAFQKELTCLVCLNFLLDPVTIGCGHSFCRSCLCLFWEQAKVPASCPVCRQRSEQTSFKTSFLLKNLVSTVRKASFRQFLKCEEHLCATHKQKKTIFCEANKSLLCLVCSQGQEHKTHRHCLAEEAAEESWEKLAKQMTSLWEKIQETERNLKKSSRGTDPWMFYVYRHGDMIRRTYQMAPPFLPEEEDYYVESIVKEGQNIYNQLRRRQEEIIRKKRELREIHKELIQMCSKPDVELLQELEDKLKWSESAQLHVPQPLLPELPARPMSGLMDWLNHFRVNFSLSNEVSSQHIRLFDDARRLTYEHDSLHASLDGGTLKYFASWGDQSFTSGKQYWEMLVDRSWDWAVGVCKDSWIRKDDGILDTSNNDNFLLVCVKQDDHYQLWTTAPTTPLYIERPLGRVGVFLDCDSGSISFVDVAKRTLLWRYDDGVCTFPVRPFFCTGHR", "length": 452, "header": "tr|E1BKE6-1|E1BKE6_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BKE6-1" }, "isoforms": [ { "isoform_ac": "E1BKE6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKE6/entry#E1BKE6-1", "sequence": { "sequence": "MDSEIPEAFQKELTCLVCLNFLLDPVTIGCGHSFCRSCLCLFWEQAKVPASCPVCRQRSEQTSFKTSFLLKNLVSTVRKASFRQFLKCEEHLCATHKQKKTIFCEANKSLLCLVCSQGQEHKTHRHCLAEEAAEESWEKLAKQMTSLWEKIQETERNLKKSSRGTDPWMFYVYRHGDMIRRTYQMAPPFLPEEEDYYVESIVKEGQNIYNQLRRRQEEIIRKKRELREIHKELIQMCSKPDVELLQELEDKLKWSESAQLHVPQPLLPELPARPMSGLMDWLNHFRVNFSLSNEVSSQHIRLFDDARRLTYEHDSLHASLDGGTLKYFASWGDQSFTSGKQYWEMLVDRSWDWAVGVCKDSWIRKDDGILDTSNNDNFLLVCVKQDDHYQLWTTAPTTPLYIERPLGRVGVFLDCDSGSISFVDVAKRTLLWRYDDGVCTFPVRPFFCTGHR", "length": 452, "header": "tr|E1BKE6-1|E1BKE6_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1BKE6-1" }, "locus": { "chromosome": "29", "start_pos": 5690841, "end_pos": 5684573, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012117.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012117.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012117.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012117.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1BKE6", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKE6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 452, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKE6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKE6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 131, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 269, "end_pos": 452, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKE6" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 56, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 288, "end_pos": 290 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKF2-1", "uniprot_ac": "E1BKF2", "uniprot_id": "E1BKF2_BOVIN", "mass": { "chemical_mass": 51855.0, "monoisotopic_mass": 51855.0 }, "refseq": { "ac": "XP_005224855", "name": "transmembrane protein 180", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224855" }, "gene_names": [ { "name": "LOC101905757", "type": "recommended", "evidence": [ { "id": "E1BKF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKF2" } ] }, { "name": "LOC101905757", "type": "synonym", "evidence": [ { "id": "XP_005224855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224855" } ] } ], "protein_names": [ { "name": "Transmembrane protein 180", "type": "recommended", "evidence": [ { "id": "E1BKF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKF2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 180", "type": "synonym", "evidence": [ { "id": "XP_005224855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224855" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKF2", "url": "https://www.uniprot.org/uniprotkb/E1BKF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101905757", "url": "https://www.uniprot.org/uniprotkb/E1BKF2", "locus": {} } ], "crossref": [ { "id": "E1BKF2", "url": "https://alphafold.ebi.ac.uk/entry/E1BKF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032373", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032373", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101905757", "url": "https://www.ncbi.nlm.nih.gov/gene/101905757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BKF2", "url": "https://www.orthodb.org/?gene=E1BKF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28658:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28658:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224855", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224855", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKF2", "url": "https://www.uniprot.org/uniprotkb/E1BKF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKF2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTFLNIKPIAWAFSLTTLGTEMLNSVFSFYYVKLFLHLYKVSEVAFYQAQMILMIWNALNDLTGYFHNNSKADCCSSRHSSVLYGAPLYAAAFLLPWFPWKYYHEGDWLSGLHLVVSLCAFDSTLTFVQQAQCVLFAEIFTRYESRLQLIKINQVASLVGSTSILFCGLISDNMEILLNFQVIAVVVAILATASLYAGMCHISHLEPKRSPEENLFSETVQDLPWTSVISLMRQILTQKNFRLFLIVNFFQVFHLTFFSNFMMIFVDNLIPTDVLPSSIRSIMYGAGFICPQCLVLISQSWLRKFGYYKIILFSFYLEGTASIVMLLLGQQYYYFLALYLTVIMVIVQASFCLFNLPLADMVDADLLKFNRQSPLSSMVFGINALFTKPAQSLAPMVILSRLNQFGYGNPNKSTILDLHEAIFNLICLVPLGIAAIQILVWSPFSIRKKTDYTGAF", "length": 456, "header": "tr|E1BKF2-1|E1BKF2_BOVIN Isoform 1 of Transmembrane protein 180 OS=Bos taurus OX=9913 GN=LOC101905757 PE=4 SV=4 CANONICAL=E1BKF2-1" }, "isoforms": [ { "isoform_ac": "E1BKF2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF2/entry#E1BKF2-1", "sequence": { "sequence": "MTFLNIKPIAWAFSLTTLGTEMLNSVFSFYYVKLFLHLYKVSEVAFYQAQMILMIWNALNDLTGYFHNNSKADCCSSRHSSVLYGAPLYAAAFLLPWFPWKYYHEGDWLSGLHLVVSLCAFDSTLTFVQQAQCVLFAEIFTRYESRLQLIKINQVASLVGSTSILFCGLISDNMEILLNFQVIAVVVAILATASLYAGMCHISHLEPKRSPEENLFSETVQDLPWTSVISLMRQILTQKNFRLFLIVNFFQVFHLTFFSNFMMIFVDNLIPTDVLPSSIRSIMYGAGFICPQCLVLISQSWLRKFGYYKIILFSFYLEGTASIVMLLLGQQYYYFLALYLTVIMVIVQASFCLFNLPLADMVDADLLKFNRQSPLSSMVFGINALFTKPAQSLAPMVILSRLNQFGYGNPNKSTILDLHEAIFNLICLVPLGIAAIQILVWSPFSIRKKTDYTGAF", "length": 456, "header": "tr|E1BKF2-1|E1BKF2_BOVIN Isoform 1 of Transmembrane protein 180 OS=Bos taurus OX=9913 GN=LOC101905757 PE=4 SV=4 CANONICAL=E1BKF2-1" }, "locus": { "chromosome": "25", "start_pos": 20076719, "end_pos": 20040925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045934.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045934.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043280.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043280.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101905757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905757", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BKF2", "url": "https://www.uniprot.org/uniprotkb/E1BKF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 456, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKF2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKF2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 411, "end_pos": 413 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKF5-1", "uniprot_ac": "E1BKF5", "uniprot_id": "E1BKF5_BOVIN", "mass": { "chemical_mass": 24203.0, "monoisotopic_mass": 24203.0 }, "refseq": { "ac": "XP_024850667", "name": "protein HIDE1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850667" }, "gene_names": [ { "name": "C7H19orf38", "type": "recommended", "evidence": [ { "id": "E1BKF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKF5" } ] }, { "name": "C7H19orf38", "type": "synonym", "evidence": [ { "id": "XP_024850667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850667" } ] } ], "protein_names": [ { "name": "Chromosome 7 C19orf38 homolog", "type": "synonym", "evidence": [ { "id": "E1BKF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKF5/entry#names_and_taxonomy" } ] }, { "name": "protein HIDE1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024850667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850667" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKF5", "url": "https://www.uniprot.org/uniprotkb/E1BKF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C7H19orf38", "url": "https://www.uniprot.org/uniprotkb/E1BKF5", "locus": { "chromosome": "7", "start_pos": 15319593, "end_pos": 15300891, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004224", "url": "https://www.ensembl.org/id/ENSBTAG00000004224" } ] } } ], "crossref": [ { "id": "E1BKF5", "url": "https://alphafold.ebi.ac.uk/entry/E1BKF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004224", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004224", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100294941", "url": "https://www.ncbi.nlm.nih.gov/gene/100294941", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100294941", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294941", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NFLGANF", "url": "https://omabrowser.org/oma/group/NFLGANF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR36859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36859:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36859:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024850667", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850667", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKF5", "url": "https://www.uniprot.org/uniprotkb/E1BKF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPWIVLLFAAGSLAIPAPSIMLVPPHPSSKEDPIHISCMAPRGFPGANFTLYQDGEVVELLKAPKDQLRVIFNLSGGSREVRGGPFCCQYSVLGENRQPQLSNLSEPVHVSFPVPTWILALSLSLAGAALLLAGLVIIALIIRKVKVKNLNKRRERESCWVNIATTDMSFDNSLFTIMKMTSEEDAANLDAPSGSTETPGPRKRPTSTSSSPEPPEFSTFRAC", "length": 223, "header": "tr|E1BKF5-1|E1BKF5_BOVIN Isoform 1 of Chromosome 7 C19orf38 homolog OS=Bos taurus OX=9913 GN=C7H19orf38 PE=4 SV=2 CANONICAL=E1BKF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF5/entry#A0AAA9SBU5-1", "sequence": { "sequence": "MRSNILLLAGISSILQSLKAQWLGGAGSEPWATLASARFPDQTREERCPGLSCCLQPVSTPGTGAAGGSTGSLAIPAPSIMLVPPHPSSKEDPIHISCMAPRGFPGANFTLYQDGEVVELLKAPKDQLRVIFNLSGGSREVRGGPFCCQYSVLGENRQPQLSNLSEPVHVSFPVPTWILALSLSLAGAALLLAGLVIIALIIRKVKVKNLNKRRERESCWVNIATTDMSFDNSLFTIMKMTSEEDAANLDAPSGSTETPGPRKRPTSTSSSPEPPEFSTFRAC", "length": 283, "header": "tr|A0AAA9SBU5-1|A0AAA9SBU5_BOVIN Computationally mapped isoform of Chromosome 7 C19orf38 homolog OS=Bos taurus OX=9913 GN=C7H19orf38 PE=4 SV=1 CANONICAL=E1BKF5-1" }, "locus": { "chromosome": "7", "start_pos": 15318854, "end_pos": 15303992, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080968.1" } ] } }, { "isoform_ac": "E1BKF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF5/entry#E1BKF5-1", "sequence": { "sequence": "MPWIVLLFAAGSLAIPAPSIMLVPPHPSSKEDPIHISCMAPRGFPGANFTLYQDGEVVELLKAPKDQLRVIFNLSGGSREVRGGPFCCQYSVLGENRQPQLSNLSEPVHVSFPVPTWILALSLSLAGAALLLAGLVIIALIIRKVKVKNLNKRRERESCWVNIATTDMSFDNSLFTIMKMTSEEDAANLDAPSGSTETPGPRKRPTSTSSSPEPPEFSTFRAC", "length": 223, "header": "tr|E1BKF5-1|E1BKF5_BOVIN Isoform 1 of Chromosome 7 C19orf38 homolog OS=Bos taurus OX=9913 GN=C7H19orf38 PE=4 SV=2 CANONICAL=E1BKF5-1" }, "locus": { "chromosome": "7", "start_pos": 15318854, "end_pos": 15308873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045933.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045933.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043279.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043279.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100294941", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294941", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VG55-1", "protein_name": "Chromosome 2 C19orf38 homolog", "gene_name": "C19orf38", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPWTVLLFAAGSLAIPAPSIMLVPPHPSSQEDPIHISCVAPQEFPGANFTLYQGGQVVQQEQAPVDQLKVTFNLSGGSQEAPGRPFYCQYGVLGEHRQPQLSDLSEPMHISFPVPTWILALSLSLAGAFLLLAGLVIIAMVVRKVKLKKLQKKRERESCWAQVNFPATDMSFDNSLFTISKMTSEEDAATVDAPSGSNKTPDNSGPWKRTNSTSSSPEPPEFSTFRAC", "length": 228 }, "evidence": [ { "id": "E1BKF5", "url": "https://omabrowser.org/oma/group/E1BKF5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QL30-1", "protein_name": "Protein HIDE1", "gene_name": "CUNH19orf38", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGREMPWTILLFASGSLAIPAPSIFLVPPYPNSQDDPIFISCTAPEDFLGANFTLFRGREVAQLLQAPSDQPGVTFNVTSGGSEAAGGIFRCQYGVIGEHSQPQLSDLSQPVQISFPVPTWIMVLSLSLAGAVLLLTGLVAVAVVVRKAKIKNLQKQRERESCWAQINFTNTDMSFDNSLFAISTKMTQEDLVATLDMHPCNSGPQKTPTSTPSSPELPEFSTFRACQ", "length": 228 }, "evidence": [ { "id": "E1BKF5", "url": "https://omabrowser.org/oma/group/E1BKF5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A8MVS5-1", "protein_name": "Protein HIDE1", "gene_name": "HIDE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPWTILLFAAGSLAIPAPSIRLVPPYPSSQEDPIHIACMAPGNFPGANFTLYRGGQVVQLLQAPTDQRGVTFNLSGGSSKAPGGPFHCQYGVLGELNQSQLSDLSEPVNVSFPVPTWILVLSLSLAGALFLLAGLVAVALVVRKVKLRNLQKKRDRESCWAQINFDSTDMSFDNSLFTVSAKTMPEEDPATLDDHSGTTATPSNSRTRKRPTSTSSSPETPEFSTFRACQ", "length": 230 }, "evidence": [ { "id": "E1BKF5", "url": "https://omabrowser.org/oma/group/E1BKF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZMI7-1", "protein_name": "Similar to human chromosome 19 open reading frame 38", "gene_name": "C8h19orf38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGEMLSQTYMGGEMPWTILLFASGSLAIPAPSIFLVPPFPSSREDPIYLSCTAPKDILGANFTLFRGGEAVQLLQAPSDQHSVTFNVTGSGSGGSNEAAGGNFRCQYGVLGEHSEPQLSDFSQEVQVSFPVPTWILALSLSLAGAVLLSGLVVIAVLVRKAKAKNLQMQRERESCWAQINFTNTDMSFDNSLFAISTKMTQEDSMVTLDSGPRKRPTSASFSPEPPEFSTFRACQ", "length": 236 }, "evidence": [ { "id": "E1BKF5", "url": "https://omabrowser.org/oma/group/E1BKF5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q75VT8-1", "protein_name": "Protein HIDE1", "gene_name": "Hide1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPWTILLFASGSLAIPAPSISLVPPYPSSHEDPIYISCTAPGDILGANFTLFRGGEVVQLLQAPSDRPDVTFNVTGGGSGGGGEAAGGNFCCQYGVMGEHSQPQLSDFSQQVQVSFPVPTWILALSLSLAGAVLFSGLVAITVLVRKAKAKNLQKQRERESCWAQINFTNTDMSFDNSLFAISTKMTQEDSVATLDSGPRKRPTSASSSPEPPEFSTFRACQ", "length": 222 }, "evidence": [ { "id": "E1BKF5", "url": "https://omabrowser.org/oma/group/E1BKF5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKF5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKF5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKF5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKF5" }, { "id": "PF17737", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17737" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C19orf38 Ig", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 112, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKH6-1", "uniprot_ac": "E1BKH6", "uniprot_id": "E1BKH6_BOVIN", "mass": { "chemical_mass": 55007.0, "monoisotopic_mass": 55007.0 }, "refseq": { "ac": "XP_002686458", "name": "EF-hand calcium-binding domain-containing protein 14 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686458" }, "gene_names": [ { "name": "EFCAB14", "type": "recommended", "evidence": [ { "id": "E1BKH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKH6" } ] }, { "name": "EFCAB14", "type": "synonym", "evidence": [ { "id": "XP_002686458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686458" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 14", "type": "synonym", "evidence": [ { "id": "E1BKH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKH6/entry#names_and_taxonomy" } ] }, { "name": "EF-hand calcium-binding domain-containing protein 14 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002686458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686458" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKH6", "url": "https://www.uniprot.org/uniprotkb/E1BKH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB14", "url": "https://www.uniprot.org/uniprotkb/E1BKH6", "locus": { "chromosome": "3", "start_pos": 99457018, "end_pos": 99421793, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000097", "url": "https://www.ensembl.org/id/ENSBTAG00000000097" } ] } } ], "crossref": [ { "id": "E1BKH6", "url": "https://alphafold.ebi.ac.uk/entry/E1BKH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000097", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000097", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512180", "url": "https://www.ncbi.nlm.nih.gov/gene/512180", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512180", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512180", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BKH6", "url": "https://www.orthodb.org/?gene=E1BKH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15717", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15717", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15717:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15717:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002686458", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686458", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKH6", "url": "https://www.uniprot.org/uniprotkb/E1BKH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKH6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKRKELNALIGLAGDSRRKKPKKGSGHRLLRTEPPDSDSESSSEEEEEFGVAGNRSRFVKGDYLRCCRICYPLCAFVILAACVVACVGLVWMQVALKEDLDSLKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGQLGLNNVWINITEMNKQISLLTSAVNHLKANVKSAADLISLPATVEGLQKSVASIGNTLNSVHLAVEAIQKTVDEHKKTVELLQSDMNQHTLKESNGSNQIIPSPSTISELDNKTHSENLKQDILYLHSFLEEVNSARVGYQRQNDLKLEGMNETISNLTERVNLIERDLVAMSKVEKQANLSSSMVNDRAATLKRESLHQVTNRIKSVKSQGIKKEDSSDSQVSKLREKLQLISALTNKPESSRPPKTASEEQVQNFTSQPSTLPKFPQSLGDQIEKAVQLRPVSLPGISSIEDLQGLFHKTGQDVDGKLTYQQIEDTLESVGPEPERLREFDSDGDGRYSFLELRAALGV", "length": 494, "header": "tr|E1BKH6-1|E1BKH6_BOVIN Isoform 1 of EF-hand calcium binding domain 14 OS=Bos taurus OX=9913 GN=EFCAB14 PE=4 SV=3 CANONICAL=E1BKH6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKH6/entry#A0AAA9RYJ8-1", "sequence": { "sequence": "MKKRKELNALIGLAGDSRRKKPKKGSGHRLLRTEPPDSDSESSSEEEEEFGVAGNRSRFVKGDYLRCCRICYPLCAFVILAACVVACVGLVWMQVALKEDLDSLKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGQLGLNNVWINITEMNKQISLLTSAVNHLKANVKSAADLISLPATVEGLQKNQHTLKESNGSNQIIPSPSTISELDNKTHSENLKQDILYLHSFLEEVNSARVGYQRQNDLKLEGMNETISNLTERVNLIERDLVAMSKVEKQANLSSSMVNDRAATLKRESLHQVTNRIKSVKSQGIKKEDSSDSQVSKLREKLQLISALTNKPESSRPPKTASEEQVQNFTSQPSTLPKFPQSLGDQIEKAVQLRPVSLPGISSIEDLQGLFHKTGQDVDGKLTYQQIEDTLESVGPEPERLREFDSDGDGRYSFLELRAALGV", "length": 457, "header": "tr|A0AAA9RYJ8-1|A0AAA9RYJ8_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 14 OS=Bos taurus OX=9913 GN=EFCAB14 PE=4 SV=1 CANONICAL=E1BKH6-1" }, "locus": { "chromosome": "3", "start_pos": 99456014, "end_pos": 99422085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103745.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103745.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078650.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078650.1" } ] } }, { "isoform_ac": "A0AAA9T9L0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKH6/entry#A0AAA9T9L0-1", "sequence": { "sequence": "MKKRKELNALIGLAGDSRRKKPKKGSGHRLLRTEPPDSDSESSSEEEEEFGVAGNRSRFVKGDYLRCCRICYPLCAFVILAACVVACVGLVWMQVALKEDLDSLKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGQLGLNNVWINITEMNKQISLLTSAVNHLKANVKSAADLISLPATVEGLQKSVASIGNTLNSVHLAVEAIQKTVDEHKKTVELLQSDMNQHTLKESNGSNQIIPSPSTISELDNKTHSENLKQDILYLHSFLEEVNSARVGYQRQNDLKLEGMNETISNLTERVNLIERDLVAMSKVEKQANLSSSMKEDSSDSQVSKLREKLQLISALTNKPESSRPPKTASEEQVQNFTSQPSTLPKFPQSLGDQIEKAVQLRPVSLPGISSIEDLQGLFHKTGQDVDGKLTYQQIEDTLESVGPEPERLREFDSDGDGRYSFLELRAALGV", "length": 465, "header": "tr|A0AAA9T9L0-1|A0AAA9T9L0_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 14 OS=Bos taurus OX=9913 GN=EFCAB14 PE=4 SV=1 CANONICAL=E1BKH6-1" }, "locus": { "chromosome": "3", "start_pos": 99456014, "end_pos": 99422085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129690.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129690.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095391.1" } ] } }, { "isoform_ac": "E1BKH6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKH6/entry#E1BKH6-1", "sequence": { "sequence": "MKKRKELNALIGLAGDSRRKKPKKGSGHRLLRTEPPDSDSESSSEEEEEFGVAGNRSRFVKGDYLRCCRICYPLCAFVILAACVVACVGLVWMQVALKEDLDSLKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGQLGLNNVWINITEMNKQISLLTSAVNHLKANVKSAADLISLPATVEGLQKSVASIGNTLNSVHLAVEAIQKTVDEHKKTVELLQSDMNQHTLKESNGSNQIIPSPSTISELDNKTHSENLKQDILYLHSFLEEVNSARVGYQRQNDLKLEGMNETISNLTERVNLIERDLVAMSKVEKQANLSSSMVNDRAATLKRESLHQVTNRIKSVKSQGIKKEDSSDSQVSKLREKLQLISALTNKPESSRPPKTASEEQVQNFTSQPSTLPKFPQSLGDQIEKAVQLRPVSLPGISSIEDLQGLFHKTGQDVDGKLTYQQIEDTLESVGPEPERLREFDSDGDGRYSFLELRAALGV", "length": 494, "header": "tr|E1BKH6-1|E1BKH6_BOVIN Isoform 1 of EF-hand calcium binding domain 14 OS=Bos taurus OX=9913 GN=EFCAB14 PE=4 SV=3 CANONICAL=E1BKH6-1" }, "locus": { "chromosome": "3", "start_pos": 99456014, "end_pos": 99422085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000106.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000106.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000106.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000106.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512180", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512180", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BKH6", "url": "https://www.uniprot.org/uniprotkb/E1BKH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 494, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKH6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKH6" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 433, "end_pos": 468, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 238, "end_pos": 240 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKI7-1", "uniprot_ac": "E1BKI7", "uniprot_id": "E1BKI7_BOVIN", "mass": { "chemical_mass": 26735.0, "monoisotopic_mass": 26735.0 }, "refseq": { "ac": "XP_059734829", "name": "EF-hand calcium-binding domain-containing protein 9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734829" }, "gene_names": [ { "name": "EFCAB9", "type": "recommended", "evidence": [ { "id": "E1BKI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ] }, { "name": "EFCAB9", "type": "synonym", "evidence": [ { "id": "XP_059734829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734829" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 9", "type": "synonym", "evidence": [ { "id": "E1BKI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKI7/entry#names_and_taxonomy" } ] }, { "name": "EF-hand calcium-binding domain-containing protein 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059734829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734829" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB9", "url": "https://www.uniprot.org/uniprotkb/E1BKI7", "locus": { "chromosome": "20", "start_pos": 3992217, "end_pos": 3972772, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008876", "url": "https://www.ensembl.org/id/ENSBTAG00000008876" } ] } } ], "crossref": [ { "id": "E1BKI7", "url": "https://alphafold.ebi.ac.uk/entry/E1BKI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008876", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008876", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618333", "url": "https://www.ncbi.nlm.nih.gov/gene/618333", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKI7", "url": "https://www.orthodb.org/?gene=E1BKI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47065", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47065", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47065:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47065:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059734829", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKI7-1", "url": "https://www.uniprot.org/uniprotkb/E1BKI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLKQGSFLWYLYLDKLYCLLSVRNVKALVEYFHLLDVHHKKTLNGQYFHVLFYHFLHHVTDLTRNQITVVFNMLDWNAVGEIGFDQFYMLVCILLAQENHLEEQFIFRHSRPVFELLDLDGELKIGPDHLHMYNFLFNIKKQQLRDLYYNFDITGDRLLNYKEFKLFTIFSMDKYQESQKAEKEKKKEKAVLKKKLSQVNESQRESLLGIQPFESISNYNC", "length": 222, "header": "tr|E1BKI7-1|E1BKI7_BOVIN Isoform 1 of EF-hand calcium binding domain 9 OS=Bos taurus OX=9913 GN=EFCAB9 PE=4 SV=4 CANONICAL=E1BKI7-1" }, "isoforms": [ { "isoform_ac": "E1BKI7-1", "url": "https://www.uniprot.org/uniprotkb/E1BKI7/entry#E1BKI7-1", "sequence": { "sequence": "MKLKQGSFLWYLYLDKLYCLLSVRNVKALVEYFHLLDVHHKKTLNGQYFHVLFYHFLHHVTDLTRNQITVVFNMLDWNAVGEIGFDQFYMLVCILLAQENHLEEQFIFRHSRPVFELLDLDGELKIGPDHLHMYNFLFNIKKQQLRDLYYNFDITGDRLLNYKEFKLFTIFSMDKYQESQKAEKEKKKEKAVLKKKLSQVNESQRESLLGIQPFESISNYNC", "length": 222, "header": "tr|E1BKI7-1|E1BKI7_BOVIN Isoform 1 of EF-hand calcium binding domain 9 OS=Bos taurus OX=9913 GN=EFCAB9 PE=4 SV=4 CANONICAL=E1BKI7-1" }, "locus": { "chromosome": "20", "start_pos": 3992282, "end_pos": 3986718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011687.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011687.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011687.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011687.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" }, { "name": "calcium ion sensor activity", "id": "GO:0061891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061891", "evidence": [ { "database": "UniProtKB", "id": "E1BKI7", "url": "https://www.uniprot.org/uniprotkb/E1BKI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 222, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKI7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 201, "end_pos": 203 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKJ8-1", "uniprot_ac": "E1BKJ8", "uniprot_id": "E1BKJ8_BOVIN", "mass": { "chemical_mass": 68350.0, "monoisotopic_mass": 68350.0 }, "refseq": { "ac": "NP_001193125", "name": "kelch-like protein 24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193125" }, "gene_names": [ { "name": "KLHL24", "type": "recommended", "evidence": [ { "id": "E1BKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ] }, { "name": "KLHL24", "type": "synonym", "evidence": [ { "id": "NP_001193125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193125" } ] } ], "protein_names": [ { "name": "Kelch-like protein 24", "type": "recommended", "evidence": [ { "id": "E1BKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8/entry#names_and_taxonomy" } ] }, { "name": "Kainate receptor-interacting protein for GluR6", "type": "synonym", "evidence": [ { "id": "E1BKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 24", "type": "synonym", "evidence": [ { "id": "NP_001193125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193125" } ] }, { "name": "kelch-like protein 24", "type": "synonym", "evidence": [ { "id": "NP_001193125", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193125" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL24", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8", "locus": { "chromosome": "1", "start_pos": 83449266, "end_pos": 83481681, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017450", "url": "https://www.ensembl.org/id/ENSBTAG00000017450" } ] } } ], "crossref": [ { "id": "E1BKJ8", "url": "https://alphafold.ebi.ac.uk/entry/E1BKJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017450", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18253", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18253", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18463", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18463", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533510", "url": "https://www.ncbi.nlm.nih.gov/gene/533510", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030596", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030596", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533510", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533510", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDCYDPV", "url": "https://omabrowser.org/oma/group/NDCYDPV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKJ8", "url": "https://www.orthodb.org/?gene=E1BKJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193125", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGREFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINGRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600, "header": "tr|E1BKJ8-1|E1BKJ8_BOVIN Isoform 1 of Kelch-like protein 24 OS=Bos taurus OX=9913 GN=KLHL24 PE=4 SV=2 CANONICAL=E1BKJ8-1" }, "isoforms": [ { "isoform_ac": "E1BKJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8/entry#E1BKJ8-1", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGREFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINGRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600, "header": "tr|E1BKJ8-1|E1BKJ8_BOVIN Isoform 1 of Kelch-like protein 24 OS=Bos taurus OX=9913 GN=KLHL24 PE=4 SV=2 CANONICAL=E1BKJ8-1" }, "locus": { "chromosome": "1", "start_pos": 83473280, "end_pos": 83449532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023192.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023192.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023192.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023192.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533510", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533510", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U665-1", "protein_name": "Kelch-like protein 24", "gene_name": "KLHL24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVLILGRRLNREDSGIRDSPATKRKVFEMDPKSLSGPEFFDFSSGSSHAESILQIFNEFRDSRLFTDVIICVEGREFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCRNFALQTFEDVSQHEEFLELGKDELIDYICSDELVITKEEMVFEAVMRWVYRAVELRRPVLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPDTNSWLLRATIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPIEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATGIITGVAAMPRPVSYHGCVTIHRYNEKGFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SGA5-1", "protein_name": "Kelch-like protein 24", "gene_name": "KLHL24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGREFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINGRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I3I7-1", "protein_name": "Kelch-like protein 24", "gene_name": "Klhl24", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q56A24-1", "protein_name": "Kelch-like protein 24", "gene_name": "Klhl24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6TFL4-1", "protein_name": "Kelch-like protein 24", "gene_name": "KLHL24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BRG6-1", "protein_name": "Kelch-like protein 24", "gene_name": "Klhl24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL", "length": 600 }, "evidence": [ { "id": "E1BKJ8", "url": "https://omabrowser.org/oma/group/E1BKJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BKJ8", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKJ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 600, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKJ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKJ8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKJ8" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 133, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKK5-1", "uniprot_ac": "E1BKK5", "uniprot_id": "E1BKK5_BOVIN", "mass": { "chemical_mass": 26536.0, "monoisotopic_mass": 26536.0 }, "refseq": {}, "gene_names": [ { "name": "BRME1", "type": "recommended", "evidence": [ { "id": "E1BKK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKK5" } ] } ], "protein_names": [ { "name": "Break repair meiotic recombinase recruitment factor 1", "type": "synonym", "evidence": [ { "id": "E1BKK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKK5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKK5", "url": "https://www.uniprot.org/uniprotkb/E1BKK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRME1", "url": "https://www.uniprot.org/uniprotkb/E1BKK5", "locus": { "chromosome": "7", "start_pos": 11805899, "end_pos": 11784266, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006064", "url": "https://www.ensembl.org/id/ENSBTAG00000006064" } ] } } ], "crossref": [ { "id": "E1BKK5", "url": "https://alphafold.ebi.ac.uk/entry/E1BKK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKK5", "url": "https://www.orthodb.org/?gene=E1BKK5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14583", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14583", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14583:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14583:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15710", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15710", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BKK5", "url": "https://www.uniprot.org/uniprotkb/E1BKK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKK5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKRKKLRTSGREGLHLPKLPKNPRIEDSDGATSQSSLLDSWHHPEESEGGSGLTPSAEQSREEPGQAASSSPDNEADAPSGLLGQPEREPVPLPPSQNSVGKFVPQFAKPRKTVTRQAERREEGLRMGVFSSLFPAGGELDPCQPGTGPCADRGPRAEAQPRTRVGIKTYEAASIEDATDTVRGLVMELSNLNRLIMSTHRDLETFKRLNYYRKAKPAGKAPTPYTAKGAGTLPRGEQSWRDL", "length": 244, "header": "tr|E1BKK5-1|E1BKK5_BOVIN Isoform 1 of Break repair meiotic recombinase recruitment factor 1 OS=Bos taurus OX=9913 GN=BRME1 PE=4 SV=4 CANONICAL=E1BKK5-1" }, "isoforms": [ { "isoform_ac": "E1BKK5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKK5/entry#E1BKK5-1", "sequence": { "sequence": "MSKRKKLRTSGREGLHLPKLPKNPRIEDSDGATSQSSLLDSWHHPEESEGGSGLTPSAEQSREEPGQAASSSPDNEADAPSGLLGQPEREPVPLPPSQNSVGKFVPQFAKPRKTVTRQAERREEGLRMGVFSSLFPAGGELDPCQPGTGPCADRGPRAEAQPRTRVGIKTYEAASIEDATDTVRGLVMELSNLNRLIMSTHRDLETFKRLNYYRKAKPAGKAPTPYTAKGAGTLPRGEQSWRDL", "length": 244, "header": "tr|E1BKK5-1|E1BKK5_BOVIN Isoform 1 of Break repair meiotic recombinase recruitment factor 1 OS=Bos taurus OX=9913 GN=BRME1 PE=4 SV=4 CANONICAL=E1BKK5-1" }, "locus": { "chromosome": "7", "start_pos": 11804895, "end_pos": 11785540, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007968.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007968.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007968.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007968.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "double-strand break repair involved in meiotic recombination", "id": "GO:1990918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990918", "evidence": [ { "database": "UniProtKB", "id": "E1BKK5", "url": "https://www.uniprot.org/uniprotkb/E1BKK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKK5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 244, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKK5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKK5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKK8-1", "uniprot_ac": "E1BKK8", "uniprot_id": "E1BKK8_BOVIN", "mass": { "chemical_mass": 22025.0, "monoisotopic_mass": 22025.0 }, "refseq": {}, "gene_names": [ { "name": "C17H5orf52", "type": "recommended", "evidence": [ { "id": "E1BKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKK8" } ] } ], "protein_names": [ { "name": "Chromosome 17 C5orf52 homolog", "type": "synonym", "evidence": [ { "id": "E1BKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKK8", "url": "https://www.uniprot.org/uniprotkb/E1BKK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C17H5orf52", "url": "https://www.uniprot.org/uniprotkb/E1BKK8", "locus": { "chromosome": "17", "start_pos": 69628755, "end_pos": 69624116, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017438", "url": "https://www.ensembl.org/id/ENSBTAG00000017438" } ] } } ], "crossref": [ { "id": "E1BKK8", "url": "https://alphafold.ebi.ac.uk/entry/E1BKK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017438", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017438", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR038935", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038935", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RKMSHLY", "url": "https://omabrowser.org/oma/group/RKMSHLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKK8", "url": "https://www.orthodb.org/?gene=E1BKK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35666", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35666", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35666:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35666:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BKK8", "url": "https://www.uniprot.org/uniprotkb/E1BKK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKK8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPEEAPIPELLAKAGDENSAVGQQLRPSVTWNLDSPVAGAVAPQATSSSGTYPASAFFRHSRLSNRRDTHVGSQPKICFLRPRTAQPLVLFSLMNSSEAAVKKFLPKSHLSRVIIRDNLSAQRIYEMEIRAADKTKKKMNHLYDHLKKKFMTDQLRKLGRWRRESTNIRQYLDSIRGNKVPLKPQPNRKNQPP", "length": 194, "header": "tr|E1BKK8-1|E1BKK8_BOVIN Isoform 1 of Chromosome 17 C5orf52 homolog OS=Bos taurus OX=9913 GN=C17H5orf52 PE=4 SV=2 CANONICAL=E1BKK8-1" }, "isoforms": [ { "isoform_ac": "E1BKK8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKK8/entry#E1BKK8-1", "sequence": { "sequence": "MDPEEAPIPELLAKAGDENSAVGQQLRPSVTWNLDSPVAGAVAPQATSSSGTYPASAFFRHSRLSNRRDTHVGSQPKICFLRPRTAQPLVLFSLMNSSEAAVKKFLPKSHLSRVIIRDNLSAQRIYEMEIRAADKTKKKMNHLYDHLKKKFMTDQLRKLGRWRRESTNIRQYLDSIRGNKVPLKPQPNRKNQPP", "length": 194, "header": "tr|E1BKK8-1|E1BKK8_BOVIN Isoform 1 of Chromosome 17 C5orf52 homolog OS=Bos taurus OX=9913 GN=C17H5orf52 PE=4 SV=2 CANONICAL=E1BKK8-1" }, "locus": { "chromosome": "17", "start_pos": 69628631, "end_pos": 69624189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023182.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023182.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023182.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023182.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A061IPC2-1", "protein_name": "Uncharacterized protein C5orf52 homolog", "gene_name": "CUNH5orf52", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAFGLATIPESLSIEEDSSSQPRKTFVKWDLGSKLESVAKETTTPGPDFRRERIDSPPDLGERVLPQIHFLRPRPAIPMFLFSVLNSSDANVKKLLPKSHLSRVIIRDNLNAQRMYEMEMKASDKTKRKMSNLYDYLKKKFVADQLRKMLRWRRESLSTQRYLDKQRLFRHSA", "length": 173 }, "evidence": [ { "id": "E1BKK8", "url": "https://omabrowser.org/oma/group/E1BKK8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A6NGY3-1", "protein_name": "Uncharacterized protein C5orf52", "gene_name": "C5orf52", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTQPTRPSVTCDQGSSTIGGTAAQATTSSSATSGSNYQRDRLGRRPEIGVGGQPQICFPRPRSAQQPVLFSLMNSSEAAMKKTLPKSHLSRVIIHDNRITQRIYEMEVSALEKTKKKISHYYEHLKKKFMTEQLRKLGRWREESVNSNRYLTFGIPPPV", "length": 159 }, "evidence": [ { "id": "E1BKK8", "url": "https://omabrowser.org/oma/group/E1BKK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKK8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKL4-1", "uniprot_ac": "E1BKL4", "uniprot_id": "E1BKL4_BOVIN", "mass": { "chemical_mass": 126334.0, "monoisotopic_mass": 126334.0 }, "refseq": { "ac": "NP_001179457", "name": "cartilage intermediate layer protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179457" }, "gene_names": [ { "name": "CILP2", "type": "recommended", "evidence": [ { "id": "E1BKL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKL4" } ] }, { "name": "CILP2", "type": "synonym", "evidence": [ { "id": "NP_001179457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179457" } ] } ], "protein_names": [ { "name": "Cartilage intermediate layer protein 2", "type": "synonym", "evidence": [ { "id": "E1BKL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKL4/entry#names_and_taxonomy" } ] }, { "name": "cartilage intermediate layer protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179457", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179457" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKL4", "url": "https://www.uniprot.org/uniprotkb/E1BKL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CILP2", "url": "https://www.uniprot.org/uniprotkb/E1BKL4", "locus": { "chromosome": "7", "start_pos": 3782380, "end_pos": 3791397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014969", "url": "https://www.ensembl.org/id/ENSBTAG00000014969" } ] } } ], "crossref": [ { "id": "E1BKL4", "url": "https://alphafold.ebi.ac.uk/entry/E1BKL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014969", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014969", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520750", "url": "https://www.ncbi.nlm.nih.gov/gene/520750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RLEKPYM", "url": "https://omabrowser.org/oma/group/RLEKPYM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKL4", "url": "https://www.orthodb.org/?gene=E1BKL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15031", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15031", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15031:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15031:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23591", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23591", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23599", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23599", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23708", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23708", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23730", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23730", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179457", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKL4", "url": "https://www.uniprot.org/uniprotkb/E1BKL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLPTLLCLCVAAAHLAGARGTPDAEEPTVTAWGLEGSSLRPGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSDVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEATWGSWGPWGPCSGSCGPGRRLRRRRCSSPAGDACPGRPSEAQKCVRPRCPGCGPSTCGCPDHILLGSVVTPSGRPLPGARVSLRDWPGTIATSDAHGTFRMPGVCASSQANVSAQMDGFSAGMTQAQANSSMSSVATVVLNKLEKPYLVKHPESQVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRTHRYGAHLELHGLRPDQAGTYHCKAWNDAGAVRSGAARLTVLAPGQPACDPRPREHLIKLPDDCGQPGRGPTYLDVGLCPDTLCPSPAGSSPRCGDAGSRCCSVRRLESRKIHCSGYTLPVKVVAECGCQKCLPLRGLIRGRVVAADSREPLRFARILLGREPIGFTSYQGDFTLEVAPSTQRLVMTFVDPSGQFVDTVRVLPFDPRGAGVYHEVKAMRKKAPIILDARQSNTISLGEMGEEAPLGELIIPPGAFRRADGQPYTGAVEAQVTFVDPRNLTSAAAAPSDLLFVDGDGELAPLRTYGMFSVDLRAAGSAEQLQTGLVAVRVAADQIRMPGHMEALKLWSLNPDTGLWEEESGFQRERPASQRARREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADQPDAYTAVVTATLGGEELEPAPSRPRPLPAAVGVAQPYLDRLDYRRTDHDDPALKRSGFRINLAKPRPGEPTEANGPVYPWRSLRECQEAPVTASHFRFARVEADKYEYNVVPFREGAPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNLGGSHPRTQGQLYGLRDSRSVRDPQRPSSSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLQDYLTRHPPLAPTDDLASFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPTAGRPSLFQRLLESPSAALGDIRREMGESARVQARASSPLRTRRGRAQQ", "length": 1157, "header": "tr|E1BKL4-1|E1BKL4_BOVIN Isoform 1 of Cartilage intermediate layer protein 2 OS=Bos taurus OX=9913 GN=CILP2 PE=4 SV=1 CANONICAL=E1BKL4-1" }, "isoforms": [ { "isoform_ac": "E1BKL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKL4/entry#E1BKL4-1", "sequence": { "sequence": "MSSLPTLLCLCVAAAHLAGARGTPDAEEPTVTAWGLEGSSLRPGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSDVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEATWGSWGPWGPCSGSCGPGRRLRRRRCSSPAGDACPGRPSEAQKCVRPRCPGCGPSTCGCPDHILLGSVVTPSGRPLPGARVSLRDWPGTIATSDAHGTFRMPGVCASSQANVSAQMDGFSAGMTQAQANSSMSSVATVVLNKLEKPYLVKHPESQVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRTHRYGAHLELHGLRPDQAGTYHCKAWNDAGAVRSGAARLTVLAPGQPACDPRPREHLIKLPDDCGQPGRGPTYLDVGLCPDTLCPSPAGSSPRCGDAGSRCCSVRRLESRKIHCSGYTLPVKVVAECGCQKCLPLRGLIRGRVVAADSREPLRFARILLGREPIGFTSYQGDFTLEVAPSTQRLVMTFVDPSGQFVDTVRVLPFDPRGAGVYHEVKAMRKKAPIILDARQSNTISLGEMGEEAPLGELIIPPGAFRRADGQPYTGAVEAQVTFVDPRNLTSAAAAPSDLLFVDGDGELAPLRTYGMFSVDLRAAGSAEQLQTGLVAVRVAADQIRMPGHMEALKLWSLNPDTGLWEEESGFQRERPASQRARREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADQPDAYTAVVTATLGGEELEPAPSRPRPLPAAVGVAQPYLDRLDYRRTDHDDPALKRSGFRINLAKPRPGEPTEANGPVYPWRSLRECQEAPVTASHFRFARVEADKYEYNVVPFREGAPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNLGGSHPRTQGQLYGLRDSRSVRDPQRPSSSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLQDYLTRHPPLAPTDDLASFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPTAGRPSLFQRLLESPSAALGDIRREMGESARVQARASSPLRTRRGRAQQ", "length": 1157, "header": "tr|E1BKL4-1|E1BKL4_BOVIN Isoform 1 of Cartilage intermediate layer protein 2 OS=Bos taurus OX=9913 GN=CILP2 PE=4 SV=1 CANONICAL=E1BKL4-1" }, "locus": { "chromosome": "7", "start_pos": 3791334, "end_pos": 3782949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019927.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019927.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019927.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019927.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 217, "start_aa": "Thr", "end_pos": 217, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr217", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:520750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520750", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AIZ2-1", "protein_name": "Cartilage intermediate layer protein 2", "gene_name": "CILP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERLLLPALLALAAFCCSGAAESLENDSEPGKSDAPGKPWKVPSPEELDLNTAGGGAEWTSWFNIDHPGGDGDYESLDAIRFYYRGRVCARPVAIQARTTEWELPQDVGEVVHFSPKKGFRCVNKEQPHGKTCSNYHIRFLCPLEHIFWSHWSSWSPCSRSACGSSGTQSRRRRCVNAQAVSALKELKCRGKAVERRPCSTGPCPEPMWTEWGAWGPCSRSCGSTGTRVRRRSCQNARKLLCAGHPSEVQQCPPTPCPACPEHTLQGAVVSATGAALPGARVYLEGRPPTLLARSDTRGAFRVPGLCVSIGANVSAHRDGFAPGLTSVVSNGSGALVAHIVLQKLEKPYMVLHPTPKVRVAGQEVTFCCKASGTPVPKKYYWYQNGTLLDRTAHRYSSRLVLRALTPEQAGSYHCKASTEAGAIRSAPAQLTVLAQGQQSCKAAPEPSLVELPAECHRDAGASRYYDVGHCPSTPCAGSPADGQRCGAGARRCCGVRRMEMREIRCGGSVLPIKVVAKCGCGPCAQPRVLVQGRVTAADTGEPLRFGQIFLGKKKIGFTGFQGSFTIEVPPDTQRLVARFVDRQQRLVDAVKVLPFDRRGGAVYQEVKMMRKKEAVELDAGQTNAIPLGEASGREPIAELVIPAGAFLRPSGEVFGGTVKASVTFLDPRDMATARAASSDLSFANADGEIVPLRTYGMFAVDFRDGESGTALQTGPVEVRMDAGQIGMAEHLRKMKLWSLNPETGLWEEEGVLRPTEERRGRREERTFLVGNMEIRERRLFNLDVPEDRRCFVKVRAYSNEKFNPYEQLEGVVISLINLEPQPGFPANPRAWGRFDSVVTGPNGACLPAFCDARRPDAYTAYITATLGGEELEAVPSSPKLNPNAVGVSQPYLNKLGYRRLDHDDPDIKKTAFQVNVAKPDPNNIDETNGPIYPYRSLRECEEAPVSANHFRFYRVEVDKYEYNVVPFKESDLTSWTGDYLSWWPNPQEFRACFIKVRIEGPQEYMVRSRNEGGSHPRTVGQLYGLRDARSVRDAMREGSSGACLEFKCSGMLYDQSLVDRTLVSVIPQGSCRRTAVNGLLRDYLARHPPVADANNTAAFTMLAPVDPLGHNYGIYTVTDQNPRLAKEIAIGRCFDGTSDGFSREMKSDAGTAVTFTCQERPAGRESFFQRLLTSPAEALDEIRREMGAGELRRAPPEVLDFASGVRALSPAPPPRTPGSRRRMGRVRAQQ", "length": 1231 }, "evidence": [ { "id": "E1BKL4", "url": "https://omabrowser.org/oma/group/E1BKL4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3Z7H8-1", "protein_name": "Cartilage intermediate layer protein 2", "gene_name": "Cilp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASPLPLLYLCLAALHLAGARDATPTEEHTSTARGLQGRPPDTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPAAMGERVHANPERGFWCLNREQPRGRRCSNYHVRFRCPLEAAWGAWGAWGLCSKSCGLGRRLRRRSCQSSSGDTCPGSPQEAQKCVRSRCPGCSSDTCGCPNHILLGSVVTPSGRPLSGARVSLRTRPGTIATSGTHGTFQVPGVCAGSKASVSAQMNGFSAGTAQAHANSSNTATVTIILEELGKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRQQGSGPHLELQGLHQAQAGEYHCKAWNEAGTVRSRAALLTILAPGQQACDPRPQEHLIKLPDDCGQPGGGPTYLDVGLCADTRCPGPVGSGPRCGDAGSRCCSVLRLESRDIRCSGYVLPVKVVAECGCRKCLPRRGLVRGRVVAADSGEPLRFARILLGRAPIGFTSYQGDFTIEVPPATERLVVTFVDPSGDFVDSVRVLPFDPRGAGVYHEIRALRKAAAVLLDAERGGEIPLGSTEEAPALGELVLPPGTFHHPDGRPYTGPVEARVTFVDPRDLASASAASSDLRFLDSAGELAPLRTYGMFAVDLRAPGSTEQLHVARADVHVDADHVRMPGHAEALALWSLDPETGLWEEEGSEQGSGGFRRETAAARVRREERAFLVGALTMRERRLFNLDVPERRRCFVKVRAYGTDRFAPAEQVQGVVVTLLNLEPAPGFTANPRAWGRFDSAVTGPNGACVPAFCDAEKPDAYTAFVTAALGGEELEAAPSRPRATAAVVGVAQPYLERLGYQRTDHDDPALKRTGFRLNLARPRAGHESEAHGPVYPWRRLRDCEDAPVTDSHFRFSRVEADKYEYDVVPFHEGAPASWTGDLLAWWPNPQEFRACFLKVRLQGPQEYMVRSHNAGGTHEATRGRLYGLRDTRSVRHPERPGASAACVEFKCGGMLFDQRQVDRTLVTVTPQGSCRRVAVNTLLQDYLARHPPLAAADDPAAFAMLAPLDALGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPARPSLFQRLLENPSSALGDIRREMGQATRYSRVNQTQAGDTGPFGPGQ", "length": 1162 }, "evidence": [ { "id": "E1BKL4", "url": "https://omabrowser.org/oma/group/E1BKL4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZE05-1", "protein_name": "Cartilage intermediate layer protein 2", "gene_name": "Cilp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSPLPLLYLCIAAAHLAGARDATPTEEHTATVRGLQGRPPDPGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPAAIGERVHANPERGFWCLNREQPRGRRCSNYHVRFRCPLDPPYLPPCSAEAAWGAWGAWGLCSKSCGPGRRLRRRSCQSSSGDTCPGSPQEAQKCVRSRCPAPPKSSLCPCCSHVPLGCSSDTCGCPNHILLGSVVTPSGRPLSGARVSLRTRPGTVATSDTHGTFRVPGVCAGSKANVSARMNGFSTGTAQAHANTSNSAVVTIVLEELGKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRQQGSGPHLELQGLREEQAGEYHCKAWNEAGTVRSRAAHLTVLAPGQPACDPRPQEHLIKLPDDCGQPGGGPTYLDVGLCADTRCPGPVGSGPRCGDAGSRCCSVLRLESRDIRCSGYVLPVKVVAECGCRKCLPRRGLVRGRVVAADSGEPLRFARILLGLAPIGFTSYQGDFTIEVPPATERLVVTFVDSSGEFVDSIRVLPFDPRGAGVYHEIRVLRKAAAVLLDAEQGGEIPLGGTEEAPALGELVFPPRTFHHPDGRPYSGPVEARVTFVDPRDLASAAAASSDLRYLDSSGELAPLRTYGMFAVDLHAPGSTEQLHVARADVRVDADHVRMPGHADALALWSLDPETGLWEEEGAEQGGGGFRREKEAVRVRREERTFLVGALTVRERRLFNLDVPERRRCFVKVRAYGTDRFAPSEQVQGVVVTLLNLEPAPGFTANPRAWGRFDSAVTGPNGACVPAFCDAERPDAYTAFVTASLGGEELEAAPSRPRATAATVGVAEPYLERLGYQRTDHDDPALKRTGFRLNLARPRTGHESEAHGPVYPWRRLRDCEDAPVTDSHFRFSRVEADKYEYDVVPFHEGAPASWTGDLLAWWPNPQEFRACFLKVRLQGPQEYMVRSHNAGGTHEDTRGHLYGLRDTRSVRNPERPGASAACVEFKCGGMLFDQRQVDRTLVTVTPQGSCRRVAVNTLLQDYLARHPPLAPADDPATFAMLAPLDALGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPARPSLFQRLLENPASALGDIRREMGQAARDSRVTQTQAGDTGPFGSGQ", "length": 1188 }, "evidence": [ { "id": "E1BKL4", "url": "https://omabrowser.org/oma/group/E1BKL4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q5N7-1", "protein_name": "Cartilage intermediate layer protein 1", "gene_name": "cilp2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MWDFTVVTLVLSTVFVVSLAQGPIWDSSRLRRLNQTDRNRKLAYNTLVEPQTTGVTEWTSWFNIDHPGGNGDYERLEAIRFYYRERVCSRPVAMEARTTDWVAAADTGEVVHSSLEKGFWCINKEQPFGRSCSNYHVRFQCPPVHSYWTDWSEWTPCSATACNDVGIQVRQRKCMSTQPLPLLLSPVCVGPHIERRECSTPPCQAMWSQWGSWGACSVTCGKGRRTRRRTCHRSSTKIQCTGRPIEVQKCGNPCPVKCKRVCPGGRPDKSCSYCICDGQALHGEVFSITGVPVMNATVALASQAKIIRAHTDAKGQFKMDGLCISPQTQIVIRKDKFAPATLPVSNNSTDELWVRAILQSSEKPYIEKHPEDKVRYEGQRATLCCRATGSPKPDKYYWYHNGTLLNRTIFKYDEDLILRDLKPEQSGQYHCKATSLTGSIKSTSAVLTVFTKGTPACKSTPETHLIKLPLDCKQPGTDSKFYNAGRCPHNKCPGALDFDMRCRDGTGFCCGVKEMDAKEINCGRYTLPIKVVSECGCQTCVEPKVLVRGRVVATDNDEPLRFGHIYIGKERIGTTGYQGGFTIQVSPETQRLVVNFVDPSQKFIDTIKVFIFDKRGGAVYHDVKVMRKQEPIDINAAESNTIYLGEMKDEDPIGQLVIPPNSFHKNTGEVYEGTVKASVTFLDPRNITMAAAAPGDLNFVDDEGDMLPLRTYGMFSVDFRDGENQEVLGAGAVQVLLDTEHVKMQEHIPAMKLWSLNPDTGIWEEESNFQPTQSTIAGTGRNKREERTFLIGNMEIRERRLFNLDVPENRRCYVKVRAYMSDKFLPNEQLEGVVINLINLEPKPGYSSNPRAWGRFDSVITGPNGACLPAFCDAQRADAYTAYVTAIMGGEELEAAPSMPKMNPNIIGVSQPYLGKLDYQRSDHEDSALKKTAFRINLAKPNPNNFDETNGPIYPFQSLIACENAPVDANHFRFFRVEKDKYEYNVVPFQESDLTSWTGDYLSWWPNPQEFRACFIKVKIHGATEIMVRSRNLGGTHPQTRGQLYGIRDIRSTRDLHHPNTSAACLEFKCSGMLFDQGSVDRSLISVIPQANCRRIGINSLLQEYLIKHPPVLQNNESHAFNMLAPVDPLGHNYGIYTVTDQNPRVAKEIAIGRCFDGTSDGFSREMKSDSGVALTFSCPKRTVNRESLFQRLQTNPGLTLTQMAREMRESQGLQVRRGSTQMVAYPFGQQGRSQNRRATNTNRRRPASRTQPRQ", "length": 1255 }, "evidence": [ { "id": "E1BKL4", "url": "https://omabrowser.org/oma/group/E1BKL4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8IUL8-1", "protein_name": "Cartilage intermediate layer protein 2", "gene_name": "CILP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATSDAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPFDPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYSGPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLDRLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFARVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQARASGPLRTRRGRVRQ", "length": 1156 }, "evidence": [ { "id": "E1BKL4", "url": "https://omabrowser.org/oma/group/E1BKL4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BKL4", "url": "https://www.uniprot.org/uniprotkb/E1BKL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1157, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKL4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKL4" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 293, "end_pos": 377, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 217 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 258, "end_pos": 260 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 309, "end_pos": 311 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 615, "end_pos": 617 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKM4-1", "uniprot_ac": "E1BKM4", "uniprot_id": "E1BKM4_BOVIN", "mass": { "chemical_mass": 97626.0, "monoisotopic_mass": 97626.0 }, "refseq": { "ac": "XP_005222647", "name": "programmed cell death 6-interacting protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222647" }, "gene_names": [ { "name": "PDCD6IP", "type": "recommended", "evidence": [ { "id": "E1BKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ] }, { "name": "PDCD6IP", "type": "synonym", "evidence": [ { "id": "XP_005222647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222647" } ] } ], "protein_names": [ { "name": "Programmed cell death 6-interacting protein", "type": "recommended", "evidence": [ { "id": "E1BKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM4/entry#names_and_taxonomy" } ] }, { "name": "ALG-2-interacting protein 1", "type": "synonym", "evidence": [ { "id": "E1BKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM4/entry#names_and_taxonomy" } ] }, { "name": "programmed cell death 6-interacting protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005222647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222647" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDCD6IP", "url": "https://www.uniprot.org/uniprotkb/E1BKM4", "locus": { "chromosome": "22", "start_pos": 8088553, "end_pos": 8019015, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017426", "url": "https://www.ensembl.org/id/ENSBTAG00000017426" } ] } } ], "crossref": [ { "id": "E1BKM4", "url": "https://alphafold.ebi.ac.uk/entry/E1BKM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017426", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017426", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09240", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09240", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533406", "url": "https://www.ncbi.nlm.nih.gov/gene/533406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKM4", "url": "https://www.orthodb.org/?gene=E1BKM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23030", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23030", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23030:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23030:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13949", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13949", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5213460", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5213460", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5675482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005222647", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222647", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALNREPTVDISPDTVGTLSLIMLAQAQEVFFLKAKRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPVLAAKPCIMQAYAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKEFSDKISRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDLSGDTVPQSILTKSTSVIEQGGIQTVDQLFKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGNNFRITLDKAVHADGQVKERYQAHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLTNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEAISVTELDRIYGGLTTKVQESLKKQEDLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLAAAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPTYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRTPASAPAAALAPAPAPAGSGTTVPAPSQTPGSAPLPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ", "length": 880, "header": "tr|E1BKM4-1|E1BKM4_BOVIN Isoform 1 of Programmed cell death 6-interacting protein OS=Bos taurus OX=9913 GN=PDCD6IP PE=1 SV=4 CANONICAL=E1BKM4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM4/entry#A0AAA9SXZ4-1", "sequence": { "sequence": "MASLTRWIYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALNREPTVDISPDTVGTLSLIMLAQAQEVFFLKAKRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKPCIMQAYAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKEFSDKISRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDLSGDTVPQSILTKSTSVIEQGGIQTVDQLFKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGNNFRITLDKAVHADGQVKERYQAHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLTNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEAISVTELDRIYGGLTTKVQESLKKQEDLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLAAAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPTYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRTPASAPAAALAPAPAPAGSGTTVPAPSQTPGSAPLPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ", "length": 813, "header": "tr|A0AAA9SXZ4-1|A0AAA9SXZ4_BOVIN Computationally mapped isoform of Programmed cell death 6-interacting protein OS=Bos taurus OX=9913 GN=PDCD6IP PE=1 SV=1 CANONICAL=E1BKM4-1" }, "locus": { "chromosome": "22", "start_pos": 8087549, "end_pos": 8032110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114620.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114620.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088185.1" } ] } }, { "isoform_ac": "E1BKM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM4/entry#E1BKM4-1", "sequence": { "sequence": "MAAFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALNREPTVDISPDTVGTLSLIMLAQAQEVFFLKAKRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPVLAAKPCIMQAYAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKEFSDKISRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDLSGDTVPQSILTKSTSVIEQGGIQTVDQLFKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGNNFRITLDKAVHADGQVKERYQAHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLTNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEAISVTELDRIYGGLTTKVQESLKKQEDLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLAAAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPTYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRTPASAPAAALAPAPAPAGSGTTVPAPSQTPGSAPLPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ", "length": 880, "header": "tr|E1BKM4-1|E1BKM4_BOVIN Isoform 1 of Programmed cell death 6-interacting protein OS=Bos taurus OX=9913 GN=PDCD6IP PE=1 SV=4 CANONICAL=E1BKM4-1" }, "locus": { "chromosome": "22", "start_pos": 8087549, "end_pos": 8019214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023165.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023165.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023165.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023165.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 743, "start_aa": "Thr", "end_pos": 743, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr743", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 746, "start_aa": "Thr", "end_pos": 746, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr746", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5213460", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5213460", "resource": "Reactome", "description": "RIPK1-mediated regulated necrosis" }, { "id": "R-BTA-5675482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675482", "resource": "Reactome", "description": "Regulation of necroptotic cell death" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "Flemming body", "id": "GO:0090543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090543", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BKM4", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 880, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKM4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM4" }, { "id": "PS51180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRO1", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 397, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 743, 746 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 384, "end_pos": 386 }, { "start_pos": 771, "end_pos": 773 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKM9-1", "uniprot_ac": "E1BKM9", "uniprot_id": "E1BKM9_BOVIN", "mass": { "chemical_mass": 152834.0, "monoisotopic_mass": 152834.0 }, "refseq": { "ac": "XP_005228082", "name": "zinc finger MYM-type protein 3 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228082" }, "gene_names": [ { "name": "ZMYM3", "type": "recommended", "evidence": [ { "id": "E1BKM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM9" } ] }, { "name": "ZMYM3", "type": "synonym", "evidence": [ { "id": "XP_005228082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228082" } ] } ], "protein_names": [ { "name": "Zinc finger MYM-type containing 3", "type": "synonym", "evidence": [ { "id": "E1BKM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM9/entry#names_and_taxonomy" } ] }, { "name": "zinc finger MYM-type protein 3 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005228082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228082" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKM9", "url": "https://www.uniprot.org/uniprotkb/E1BKM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZMYM3", "url": "https://www.uniprot.org/uniprotkb/E1BKM9", "locus": { "chromosome": "X", "start_pos": 79409855, "end_pos": 79395484, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008492", "url": "https://www.ensembl.org/id/ENSBTAG00000008492" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008492", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008492", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522721", "url": "https://www.ncbi.nlm.nih.gov/gene/522721", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKM9", "url": "https://www.orthodb.org/?gene=E1BKM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45736:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45736:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228082", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228082", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM9", "url": "https://www.uniprot.org/uniprotkb/E1BKM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDASDQTLEPGPGGRTPEVVPPDPGAGANPSSPEGLLEPLAPDSPITLQSPHIEEEETTSIATGRRGSPGQEEELPQGQPQSPNGPPSPSVGETLGDGINSSQTKPGSPSPPAHPSLPGDGLTGKASEKPPERKRSERVRRVEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVAQRAGRSSVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDLADATRCSICQKTGEVLHEVSNGSVVHRLCSNSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSSEAKPQTPSQTKVENRNTIKTLQENGNLGKVKIPVKTRPAPAASTPPPPPPPPPAAPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRAMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKRDDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD", "length": 1374, "header": "tr|E1BKM9-1|E1BKM9_BOVIN Isoform 1 of Zinc finger MYM-type containing 3 OS=Bos taurus OX=9913 GN=ZMYM3 PE=4 SV=4 CANONICAL=E1BKM9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2R8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM9/entry#A0AAA9S2R8-1", "sequence": { "sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDASDQTLEPGPGGRTPEVVPPDPGAGANPSSPEGLLEPLAPDSPITLQSPHIEEEETTSIATGRRGSPGQEEELPQGQPQSPNGPPSPSVGETLGDGINSSQTKPGSPSPPAHPSLPGDGLTGKASEKPPERVQKRSERVRRVEPPKPEVVDSTESRRSGTPRTPLWRRPVREVPSMSSAHPSVSPCMRPSSSAQSPSLGILLMPLAAAYARRLERSCMRSAMAAWCTGSAAILASPNSGPTRD", "length": 349, "header": "tr|A0AAA9S2R8-1|A0AAA9S2R8_BOVIN Computationally mapped isoform of Zinc finger MYM-type containing 3 OS=Bos taurus OX=9913 GN=ZMYM3 PE=4 SV=1 CANONICAL=E1BKM9-1" }, "locus": { "chromosome": "X", "start_pos": 79399984, "end_pos": 79396371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122438.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122438.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080215.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080215.1" } ] } }, { "isoform_ac": "A0AAA9SMX5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM9/entry#A0AAA9SMX5-1", "sequence": { "sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDASDQTLEPGPGGRTPEVVPPDPGAGANPSSPEGLLEPLAPDSPITLQSPHIEEEETTSIATGRRGSPGQEEELPQGQPQSPNGPPSPSVGETLGDGINSSQTKPGSPSPPAHPSLPGDGLTGKASEKPPERVQKRSERVRRVEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVAQRAGRSSVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDLADATRCSICQKTGEVLHEVSNGSVVHRLCSNSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSSEAKPQTPSQTKVENRNTIKTLQENGNLGKIPVKTRPAPAASTPPPPPPPPPAAPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRAMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKAKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTGPGKRKRDDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD", "length": 1282, "header": "tr|A0AAA9SMX5-1|A0AAA9SMX5_BOVIN Computationally mapped isoform of Zinc finger MYM-type containing 3 OS=Bos taurus OX=9913 GN=ZMYM3 PE=4 SV=1 CANONICAL=E1BKM9-1" }, "locus": { "chromosome": "X", "start_pos": 79408578, "end_pos": 79396371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117438.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117438.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084131.1" } ] } }, { "isoform_ac": "E1BKM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM9/entry#E1BKM9-1", "sequence": { "sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDASDQTLEPGPGGRTPEVVPPDPGAGANPSSPEGLLEPLAPDSPITLQSPHIEEEETTSIATGRRGSPGQEEELPQGQPQSPNGPPSPSVGETLGDGINSSQTKPGSPSPPAHPSLPGDGLTGKASEKPPERKRSERVRRVEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVAQRAGRSSVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDLADATRCSICQKTGEVLHEVSNGSVVHRLCSNSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSSEAKPQTPSQTKVENRNTIKTLQENGNLGKVKIPVKTRPAPAASTPPPPPPPPPAAPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRAMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKRDDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD", "length": 1374, "header": "tr|E1BKM9-1|E1BKM9_BOVIN Isoform 1 of Zinc finger MYM-type containing 3 OS=Bos taurus OX=9913 GN=ZMYM3 PE=4 SV=4 CANONICAL=E1BKM9-1" }, "locus": { "chromosome": "X", "start_pos": 79408578, "end_pos": 79396371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011195.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011195.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011195.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011195.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 819, "start_aa": "Thr", "end_pos": 819, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr819", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BKM9", "url": "https://www.uniprot.org/uniprotkb/E1BKM9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BKM9", "url": "https://www.uniprot.org/uniprotkb/E1BKM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1067, "end_pos": 1069, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1173, "end_pos": 1175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1186, "end_pos": 1188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 962, "end_pos": 964, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM9" }, { "id": "SM00746", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00746" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRASH", "eco_id": "ECO_0000259", "start_pos": 311, "end_pos": 347, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 819 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1067, "end_pos": 1069 }, { "start_pos": 1173, "end_pos": 1175 }, { "start_pos": 1186, "end_pos": 1188 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 962, "end_pos": 964 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKP1-1", "uniprot_ac": "E1BKP1", "uniprot_id": "E1BKP1_BOVIN", "mass": { "chemical_mass": 55244.0, "monoisotopic_mass": 55244.0 }, "refseq": { "ac": "NP_001192602", "name": "transmembrane protein 161B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192602" }, "gene_names": [ { "name": "TMEM161B", "type": "recommended", "evidence": [ { "id": "E1BKP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP1" } ] }, { "name": "TMEM161B", "type": "synonym", "evidence": [ { "id": "NP_001192602", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192602" } ] } ], "protein_names": [ { "name": "Transmembrane protein 161B", "type": "synonym", "evidence": [ { "id": "E1BKP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP1/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 161B", "type": "synonym", "evidence": [ { "id": "NP_001192602", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192602" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKP1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM161B", "url": "https://www.uniprot.org/uniprotkb/E1BKP1", "locus": { "chromosome": "7", "start_pos": 87739194, "end_pos": 87817588, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008484", "url": "https://www.ensembl.org/id/ENSBTAG00000008484" } ] } } ], "crossref": [ { "id": "E1BKP1", "url": "https://alphafold.ebi.ac.uk/entry/E1BKP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008484", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008484", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510378", "url": "https://www.ncbi.nlm.nih.gov/gene/510378", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510378", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510378", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFALMPI", "url": "https://omabrowser.org/oma/group/RFALMPI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKP1", "url": "https://www.orthodb.org/?gene=E1BKP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13624:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13624:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192602", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKP1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVIGIQLVVTMVMASAMQKILPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKSRKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFVKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIIVLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESVSALPVDNSLPSNSVYSELPSADGKVKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 487, "header": "tr|E1BKP1-1|E1BKP1_BOVIN Isoform 1 of Transmembrane protein 161B OS=Bos taurus OX=9913 GN=TMEM161B PE=3 SV=1 CANONICAL=E1BKP1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3F6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1/entry#A0AAA9T3F6-1", "sequence": { "sequence": "MLGLSLNPRREQEKGVRWKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFVKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIIVLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESVSALPVDNSLPSNSVYSELPSADGKVKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 441, "header": "tr|A0AAA9T3F6-1|A0AAA9T3F6_BOVIN Computationally mapped isoform of Transmembrane protein 161B OS=Bos taurus OX=9913 GN=TMEM161B PE=3 SV=1 CANONICAL=E1BKP1-1" }, "locus": { "chromosome": "7", "start_pos": 87776886, "end_pos": 87740212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113678.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113678.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090229.1" } ] } }, { "isoform_ac": "A0AAA9TGD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1/entry#A0AAA9TGD5-1", "sequence": { "sequence": "MGVIGIQLVVTMVMASAMQKILPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKSRKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFVKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIIVLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVITPGGFIQNLCLPCQWIIVYPPILFTLNYHLLMGR", "length": 399, "header": "tr|A0AAA9TGD5-1|A0AAA9TGD5_BOVIN Computationally mapped isoform of Transmembrane protein 161B OS=Bos taurus OX=9913 GN=TMEM161B PE=3 SV=1 CANONICAL=E1BKP1-1" }, "locus": { "chromosome": "7", "start_pos": 87817466, "end_pos": 87740379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095237.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095237.1" } ] } }, { "isoform_ac": "A0AAA9TWC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1/entry#A0AAA9TWC7-1", "sequence": { "sequence": "MGVIGIQLVVTMVMASAMQKILPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKSRKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFVKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIIVLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESVSALPVDNSLPSNSVYSELPSADGKVKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 440, "header": "tr|A0AAA9TWC7-1|A0AAA9TWC7_BOVIN Computationally mapped isoform of Transmembrane protein 161B OS=Bos taurus OX=9913 GN=TMEM161B PE=3 SV=1 CANONICAL=E1BKP1-1" }, "locus": { "chromosome": "7", "start_pos": 87817466, "end_pos": 87740212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133741.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133741.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101754.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101754.1" } ] } }, { "isoform_ac": "E1BKP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1/entry#E1BKP1-1", "sequence": { "sequence": "MGVIGIQLVVTMVMASAMQKILPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKSRKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFVKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIIVLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESVSALPVDNSLPSNSVYSELPSADGKVKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 487, "header": "tr|E1BKP1-1|E1BKP1_BOVIN Isoform 1 of Transmembrane protein 161B OS=Bos taurus OX=9913 GN=TMEM161B PE=3 SV=1 CANONICAL=E1BKP1-1" }, "locus": { "chromosome": "7", "start_pos": 87817466, "end_pos": 87740212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011171.4", "url": "https://www.ensembl.org/id/ENSBTAT00000011171.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011171.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011171.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510378", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510378", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y238-1", "protein_name": "Transmembrane protein 161B", "gene_name": "Tmem161b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPSEEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDTAMQFLEKQGLESQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTEATFDTLRLWLIVLLCVLRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMATRVFYYLCVIALQYVAPLVMLLHMTLLLKTLGNHSWGIYPEAVSPLPVDNNLPSNLVYPELPSPDGKMKVTVMQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 487 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XRU2-1", "protein_name": "Transmembrane protein 161B", "gene_name": "TMEM161B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDRSVSLICEGVIGVQLVVTMVMASVIQKIIPHYSLARWLLCSGSLRWYQHPTEEELRILAGKQRGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTERDTIALHYFPEYQWLVDFTVAATVVYVVTEAYYSIVKPSQEMNISVVWCLLVLAFAVKVLFSLTTHYFKVEEGGERSVCVTFGFFFFVKAMAILIVTENYLEFGLESGFSNFSESAMQFLEKQGLESQGPVSKLTFKLFLAVLCSLIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESIPLMSEDTFDTVRLWIIILLCALRLAMMRSHLQAYLNLAQKSVDQMKKEAGRISTVDLQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNYSWGIYPELNSNTPVENSLLPNSAYSESLPADGKMKVTVVQITMALGSLKNIFTPLLFRGLLSFLTWWVAACLFSTSLFGLFYHQYLTVA", "length": 495 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7SY10-1", "protein_name": "Transmembrane protein 161B", "gene_name": "tmem161b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVISVQLVVTMVMASVIQKIIPHYSFARWLLCSGSLRWYQHPTEDELRTLAGKQQKGGKSKKDRKYNGHLENKPMTIPKDIDLQLETKCIAEVDTLALHYFPEFQWLVDFTVAATVVYLITELYFCVAEPSGEMNISVVWSLLVLAFVMKILFSLTAHYFRLEEGGERSLCITFAFFFFVKAMAILIVTENYLEFGLETGFANFSESAVQFLENQGLESQGPISKLTFKLILALLCALIGAFLTFPGLRLAQMHLDALTLNNCKVTQTLLHINFLAPLIMVLLWVKPITKDYITNPTFGKDNVPLMSEKTYDTLRLWVILLLCVLRLAMMRHHLQAYLNLAQKGVLQMKKEAGRISTVDLQKMVARVFYYLCVIALQYIAPLVMLLHTTLLLKTLGGHSWVIYSDESLPCLSNEDSSPAEVGQSQMEASQTVAQLSVALGGLRTVFSPLLFRGLLSFFTWWIAACLFSTSLFGLFYHQYLMAA", "length": 484 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8C2L6-1", "protein_name": "Transmembrane protein 161B", "gene_name": "Tmem161b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPSEEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATIVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNMATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGRESVPLMTEATFDTLRLWLIILLCVLRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHMTLLLKTLGNHSWGIYPEAAFPLPVDNNLPANSAYPELPSPDGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 487 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDZ6-1", "protein_name": "Transmembrane protein 161B", "gene_name": "TMEM161B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYNFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQSPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESIPLMTEATFDTLRLWLIILLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESISTLPVDNSLLSNSVYSELPSAEGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA", "length": 487 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VTF5-1", "protein_name": "Emei", "gene_name": "emei", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAVLGAQLVITLVMVSVIQKLSPHYSFAKWILCRTGLYRYLHPTDDELRSRGGVPKEKPPKGGRNKQANGSGGAAGAQFHIPRSIEVELLTSPVLERDVVHLRYFTEYQWLLDFSVYTGIVYVVSELFHFYYPLRHEVNLSMVWCLLVIFFALKLLSSLTVLYFQSEESIGERSMVIVACLVYLLVAMVVLIVDERILETGLEDAYASFNASASKFLTEQGLPSSGPASKIVVKFFLAMGCGLLGSLFTFPGLRMAKMHWDSLKYCRGNRLLQVLLNLSFVLPFILVILWIRPISRDYLTVRVFQGMQQPLLKPHVFETLRLLLVIFVVVVRFALMPIYLQSYLNLAHDKIMDLRKEAGRITNVEFKQKISSIFYYLCVVTLQFAAPLILCLYLTLMYKSLGGFSWSGIFRESVVLQHECAASETEGAGVAVSQGDGDFNIIESAQSLQASFSSLKNVFSTEVYKGFLGFATWWSYFTLFATSSLGIVYQSYFNKT", "length": 496 }, "evidence": [ { "id": "E1BKP1", "url": "https://omabrowser.org/oma/group/E1BKP1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BKP1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of heart rate", "id": "GO:0002027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002027", "evidence": [ { "database": "UniProtKB", "id": "E1BKP1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1" } ], "pmid": "" }, { "name": "regulation of cardiac muscle cell action potential", "id": "GO:0098901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098901", "evidence": [ { "database": "UniProtKB", "id": "E1BKP1", "url": "https://www.uniprot.org/uniprotkb/E1BKP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 487, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKP1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 203, "end_pos": 205 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 397, "end_pos": 399 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKR1-1", "uniprot_ac": "E1BKR1", "uniprot_id": "E1BKR1_BOVIN", "mass": { "chemical_mass": 66808.0, "monoisotopic_mass": 66808.0 }, "refseq": {}, "gene_names": [ { "name": "SLC22A14", "type": "recommended", "evidence": [ { "id": "E1BKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" } ] } ], "protein_names": [ { "name": "Solute carrier family 22 member 14", "type": "synonym", "evidence": [ { "id": "E1BKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKR1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC22A14", "url": "https://www.uniprot.org/uniprotkb/E1BKR1", "locus": { "chromosome": "22", "start_pos": 11763664, "end_pos": 11752094, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008463", "url": "https://www.ensembl.org/id/ENSBTAG00000008463" } ] } } ], "crossref": [ { "id": "E1BKR1", "url": "https://alphafold.ebi.ac.uk/entry/E1BKR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008463", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008463", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKR1", "url": "https://www.orthodb.org/?gene=E1BKR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BKR1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKR1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKENSLKIEFKSHPHPRNLHQHDGAESPRSCSLDMLLQRLRAIDAQDDKLTNIMDVVGEFGTFQRRLVALNFIPNFLASFFMFADIFLFTPQKPYCNTSWILAVDSNLTEAEQMNLTLPRAPNGSFLTCLMYVPVEWDLHSIIQFGLNHTDSCQNGWIYPEMKRRSLINEFDLVCGGEPNKEIVHTMFLAGLLTGAFFFGFITDKLGRYPTILLSLLELMIFGFGTAFVSSFNQYIFFRFCVSQAVVGYAISSSALLTEWLMGMYRAYAFILGHCFFAMGVVFLTGLSYSLPHWRLLFLLGGTPIFPLICYIWILPESPRWLIMKGKLEEAKQVLCYAAGVNKKTIPLSLLDKLQLPGKKVASASILDFYSNKDLRKLTLVMCSIWFAVGCNYYMLGLKIKELGVDIYLTQVIPGMMEVPARLCCIFLIEQLKRRRTLIVTLFQGAIMCFLSLTLPSGKGGHRLRRLHCLATELKSLVVLITLLGEFNLAASITMFYIYTSELFPTVLRATGLGLVSLVWAAGGISSLTLVSQNIAILAIILCCLSALVALFYCSSMPETQDQPLPDTLEHIAPHTRSISEELSNEDMLSDDVG", "length": 595, "header": "tr|E1BKR1-1|E1BKR1_BOVIN Isoform 1 of Solute carrier family 22 member 14 OS=Bos taurus OX=9913 GN=SLC22A14 PE=4 SV=4 CANONICAL=E1BKR1-1" }, "isoforms": [ { "isoform_ac": "E1BKR1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1/entry#E1BKR1-1", "sequence": { "sequence": "MAKENSLKIEFKSHPHPRNLHQHDGAESPRSCSLDMLLQRLRAIDAQDDKLTNIMDVVGEFGTFQRRLVALNFIPNFLASFFMFADIFLFTPQKPYCNTSWILAVDSNLTEAEQMNLTLPRAPNGSFLTCLMYVPVEWDLHSIIQFGLNHTDSCQNGWIYPEMKRRSLINEFDLVCGGEPNKEIVHTMFLAGLLTGAFFFGFITDKLGRYPTILLSLLELMIFGFGTAFVSSFNQYIFFRFCVSQAVVGYAISSSALLTEWLMGMYRAYAFILGHCFFAMGVVFLTGLSYSLPHWRLLFLLGGTPIFPLICYIWILPESPRWLIMKGKLEEAKQVLCYAAGVNKKTIPLSLLDKLQLPGKKVASASILDFYSNKDLRKLTLVMCSIWFAVGCNYYMLGLKIKELGVDIYLTQVIPGMMEVPARLCCIFLIEQLKRRRTLIVTLFQGAIMCFLSLTLPSGKGGHRLRRLHCLATELKSLVVLITLLGEFNLAASITMFYIYTSELFPTVLRATGLGLVSLVWAAGGISSLTLVSQNIAILAIILCCLSALVALFYCSSMPETQDQPLPDTLEHIAPHTRSISEELSNEDMLSDDVG", "length": 595, "header": "tr|E1BKR1-1|E1BKR1_BOVIN Isoform 1 of Solute carrier family 22 member 14 OS=Bos taurus OX=9913 GN=SLC22A14 PE=4 SV=4 CANONICAL=E1BKR1-1" }, "locus": { "chromosome": "22", "start_pos": 11763664, "end_pos": 11752094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011136.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011136.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011136.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011136.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1BKR1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1BKR1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "riboflavin transmembrane transporter activity", "id": "GO:0032217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032217", "evidence": [ { "database": "UniProtKB", "id": "E1BKR1", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKR1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 595, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKR1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKR1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKR1" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 562, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 116, "end_pos": 118 }, { "start_pos": 124, "end_pos": 126 }, { "start_pos": 149, "end_pos": 151 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKU6-1", "uniprot_ac": "E1BKU6", "uniprot_id": "E1BKU6_BOVIN", "mass": { "chemical_mass": 33303.0, "monoisotopic_mass": 33303.0 }, "refseq": { "ac": "XP_003587292", "name": "zinc finger protein OZF", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587292" }, "gene_names": [ { "name": "ZNF146", "type": "recommended", "evidence": [ { "id": "E1BKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ] }, { "name": "ZNF146", "type": "synonym", "evidence": [ { "id": "XP_003587292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587292" } ] } ], "protein_names": [ { "name": "Zinc finger protein OZF", "type": "recommended", "evidence": [ { "id": "E1BKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKU6/entry#names_and_taxonomy" } ] }, { "name": "Only zinc finger protein", "type": "synonym", "evidence": [ { "id": "E1BKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKU6/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 146", "type": "synonym", "evidence": [ { "id": "E1BKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKU6/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein OZF", "type": "synonym", "evidence": [ { "id": "XP_003587292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587292" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF146", "url": "https://www.uniprot.org/uniprotkb/E1BKU6", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000031687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138954", "url": "https://www.ncbi.nlm.nih.gov/gene/100138954", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138954", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138954", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LTEHENF", "url": "https://omabrowser.org/oma/group/LTEHENF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKU6", "url": "https://www.orthodb.org/?gene=E1BKU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587292", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587292", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHLSQQRICSGENPFACKVCGKIFSHKSTLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292, "header": "tr|E1BKU6-1|E1BKU6_BOVIN Isoform 1 of Zinc finger protein OZF OS=Bos taurus OX=9913 GN=ZNF146 PE=3 SV=3 CANONICAL=E1BKU6-1" }, "isoforms": [ { "isoform_ac": "E1BKU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKU6/entry#E1BKU6-1", "sequence": { "sequence": "MSHLSQQRICSGENPFACKVCGKIFSHKSTLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292, "header": "tr|E1BKU6-1|E1BKU6_BOVIN Isoform 1 of Zinc finger protein OZF OS=Bos taurus OX=9913 GN=ZNF146 PE=3 SV=3 CANONICAL=E1BKU6-1" }, "locus": { "chromosome": "18", "start_pos": 46874875, "end_pos": 46874000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131289.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131289.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079818.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138954", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138954", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GFW5-1", "protein_name": "Zinc finger protein OZF", "gene_name": "Zfp146", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHLSQQRILSGGSPFACKVCGKLFSHKSNLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNDCGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1MAP1-1", "protein_name": "Zinc finger protein OZF", "gene_name": "LOC120095168", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "FSHKSNLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNDCGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 268 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HPR4-1", "protein_name": "Zinc finger protein OZF", "gene_name": "Znf146", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHVSQQRVLSGGSPFACKVCGKLFSHKSNLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECSDCGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LFI4-1", "protein_name": "Zinc finger protein OZF", "gene_name": "ZNF146", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHLSQQRICSGENPFACKVCGKVFSHKSTLTEHEHFHNREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKSNLTEHEKIHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15072-1", "protein_name": "Zinc finger protein OZF", "gene_name": "ZNF146", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHLSQQRIYSGENPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKSNLTEHEKIHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BQN6-1", "protein_name": "Zinc finger protein OZF", "gene_name": "Znf146", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQLSQQRILSGGSPFACKVCGKLFSHKSNLTEHEHFHSREKPFECNECGKAFSQKQYVIKHQSTHSGEKLFECSDCGKAFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFICKECGKTFSGKSNLTEHEKIHIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHTH", "length": 292 }, "evidence": [ { "id": "E1BKU6", "url": "https://omabrowser.org/oma/group/E1BKU6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BKU6", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKU6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 43, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKV5-1", "uniprot_ac": "E1BKV5", "uniprot_id": "E1BKV5_BOVIN", "mass": { "chemical_mass": 26063.0, "monoisotopic_mass": 26063.0 }, "refseq": { "ac": "NP_001179934", "name": "sarcospan", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179934" }, "gene_names": [ { "name": "SSPN", "type": "recommended", "evidence": [ { "id": "E1BKV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKV5" } ] }, { "name": "SSPN", "type": "synonym", "evidence": [ { "id": "NP_001179934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179934" } ] } ], "protein_names": [ { "name": "Sarcospan", "type": "synonym", "evidence": [ { "id": "E1BKV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKV5/entry#names_and_taxonomy" } ] }, { "name": "sarcospan (Kras oncogene-associated gene)", "type": "synonym", "evidence": [ { "id": "NP_001179934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179934" } ] }, { "name": "sarcospan", "type": "synonym", "evidence": [ { "id": "NP_001179934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179934" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKV5", "url": "https://www.uniprot.org/uniprotkb/E1BKV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSPN", "url": "https://www.uniprot.org/uniprotkb/E1BKV5", "locus": { "chromosome": "5", "start_pos": 83669219, "end_pos": 83723160, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000393", "url": "https://www.ensembl.org/id/ENSBTAG00000000393" } ] } } ], "crossref": [ { "id": "E1BKV5", "url": "https://alphafold.ebi.ac.uk/entry/E1BKV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000393", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000393", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613989", "url": "https://www.ncbi.nlm.nih.gov/gene/613989", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613989", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613989", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BKV5", "url": "https://www.orthodb.org/?gene=E1BKV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15260:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15260:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9913351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179934", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKV5", "url": "https://www.uniprot.org/uniprotkb/E1BKV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRERPGRGARSQGGPPAADAAGPDDMGPKRGAGAPKESGEEARKCCGCRFPLLLALLQLALGIAVTVVGFLMAGISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFAMKLLYFVLSALGLTVCVLAVAFAAHHYAQLAQFTCGTALDSCQCKLPSSEPLSRTFVYRDVTDCTSITGTLKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRMSSGTPSEGQQQKV", "length": 242, "header": "tr|E1BKV5-1|E1BKV5_BOVIN Isoform 1 of Sarcospan OS=Bos taurus OX=9913 GN=SSPN PE=4 SV=3 CANONICAL=E1BKV5-1" }, "isoforms": [ { "isoform_ac": "E1BKV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKV5/entry#E1BKV5-1", "sequence": { "sequence": "MGRERPGRGARSQGGPPAADAAGPDDMGPKRGAGAPKESGEEARKCCGCRFPLLLALLQLALGIAVTVVGFLMAGISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFAMKLLYFVLSALGLTVCVLAVAFAAHHYAQLAQFTCGTALDSCQCKLPSSEPLSRTFVYRDVTDCTSITGTLKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRMSSGTPSEGQQQKV", "length": 242, "header": "tr|E1BKV5-1|E1BKV5_BOVIN Isoform 1 of Sarcospan OS=Bos taurus OX=9913 GN=SSPN PE=4 SV=3 CANONICAL=E1BKV5-1" }, "locus": { "chromosome": "5", "start_pos": 83722961, "end_pos": 83680892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000506.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000506.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000506.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000506.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613989", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613989", "resource": "KEGG Pathway" }, { "id": "R-BTA-9913351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913351", "resource": "Reactome", "description": "Formation of the dystrophin-glycoprotein complex (DGC)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "dystrophin-associated glycoprotein complex", "id": "GO:0016010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016010", "evidence": [ { "database": "UniProtKB", "id": "E1BKV5", "url": "https://www.uniprot.org/uniprotkb/E1BKV5" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "E1BKV5", "url": "https://www.uniprot.org/uniprotkb/E1BKV5" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "E1BKV5", "url": "https://www.uniprot.org/uniprotkb/E1BKV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKV5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 242, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKV5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKV5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKY0-1", "uniprot_ac": "E1BKY0", "uniprot_id": "E1BKY0_BOVIN", "mass": { "chemical_mass": 120797.0, "monoisotopic_mass": 120797.0 }, "refseq": { "ac": "NP_001193742", "name": "zinc finger protein 197", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193742" }, "gene_names": [ { "name": "ZNF197", "type": "recommended", "evidence": [ { "id": "E1BKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ] }, { "name": "ZNF197", "type": "synonym", "evidence": [ { "id": "NP_001193742", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193742" } ] } ], "protein_names": [ { "name": "Zinc finger protein 197", "type": "synonym", "evidence": [ { "id": "E1BKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKY0/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 197", "type": "synonym", "evidence": [ { "id": "NP_001193742", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193742" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF197", "url": "https://www.uniprot.org/uniprotkb/E1BKY0", "locus": { "chromosome": "22", "start_pos": 16445197, "end_pos": 16427650, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037803", "url": "https://www.ensembl.org/id/ENSBTAG00000037803" } ] } } ], "crossref": [ { "id": "E1BKY0", "url": "https://alphafold.ebi.ac.uk/entry/E1BKY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515564", "url": "https://www.ncbi.nlm.nih.gov/gene/515564", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515564", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515564", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVEEFSW", "url": "https://omabrowser.org/oma/group/TVEEFSW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKY0", "url": "https://www.orthodb.org/?gene=E1BKY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193742", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKY0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATMTRENWAHNALRQEGLVKGKDDTWKWGTSFQGSSSTVWETSHLHFRQLRYHETSGPQEALSRLRELCRRWLRPEARTKAQILELLVLEQFLSILPGEIRTWVQIHRPGSGEEAVALVEELQKDLDGPTLKVPAFVQDQDTLQEGLSTPGIALPHAPTGSHISAEIRSNSLTDPVVFGLLQDPQHDSPAPEASALSQEENPRNQLMALMLLTAQPQELVMFEEVSVCFTSEEWACLSPVQRALYWDVMLENYGNVTSLEWETMTENEEVTSKLNISQRADSQRGISKRFQGGVPYLLDFEEECEWQIFSSQWRNEARERDTLKKGSLCERDKKKRTPPEKRGQKWKEFEESLASDSAFSESLIGAEGKKLYKCDMCYKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLVDHQRLHSTENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFTSKSSLIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECNECGRAFSSNRNLIEHKRIHSGEKPYECNECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACNECGKGFTYNRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCSECGKDFSQNKNLVVHQRMHTGEKPYECEKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCNKVFRQRKNLTVHQKIHTDEKNCECDESEKEFSQTSNLHLQPKIHSLEDFRSYSLGSKFSWVQNANESKIKIQKI", "length": 1041, "header": "tr|E1BKY0-1|E1BKY0_BOVIN Isoform 1 of Zinc finger protein 197 OS=Bos taurus OX=9913 GN=ZNF197 PE=3 SV=2 CANONICAL=E1BKY0-1" }, "isoforms": [ { "isoform_ac": "E1BKY0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKY0/entry#E1BKY0-1", "sequence": { "sequence": "MATMTRENWAHNALRQEGLVKGKDDTWKWGTSFQGSSSTVWETSHLHFRQLRYHETSGPQEALSRLRELCRRWLRPEARTKAQILELLVLEQFLSILPGEIRTWVQIHRPGSGEEAVALVEELQKDLDGPTLKVPAFVQDQDTLQEGLSTPGIALPHAPTGSHISAEIRSNSLTDPVVFGLLQDPQHDSPAPEASALSQEENPRNQLMALMLLTAQPQELVMFEEVSVCFTSEEWACLSPVQRALYWDVMLENYGNVTSLEWETMTENEEVTSKLNISQRADSQRGISKRFQGGVPYLLDFEEECEWQIFSSQWRNEARERDTLKKGSLCERDKKKRTPPEKRGQKWKEFEESLASDSAFSESLIGAEGKKLYKCDMCYKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLVDHQRLHSTENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFTSKSSLIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECNECGRAFSSNRNLIEHKRIHSGEKPYECNECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACNECGKGFTYNRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCSECGKDFSQNKNLVVHQRMHTGEKPYECEKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCNKVFRQRKNLTVHQKIHTDEKNCECDESEKEFSQTSNLHLQPKIHSLEDFRSYSLGSKFSWVQNANESKIKIQKI", "length": 1041, "header": "tr|E1BKY0-1|E1BKY0_BOVIN Isoform 1 of Zinc finger protein 197 OS=Bos taurus OX=9913 GN=ZNF197 PE=3 SV=2 CANONICAL=E1BKY0-1" }, "locus": { "chromosome": "22", "start_pos": 16444488, "end_pos": 16432518, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055475.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055475.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051224.2", "url": "https://www.ensembl.org/id/ENSBTAP00000051224.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515564", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515564", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O14709-1", "protein_name": "Zinc finger protein 197", "gene_name": "ZNF197", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRENVAHNALRQEGLVKGKDDTWKWGTSFQGSSSSVWETSHLHFRQLRYHETSGPQEALSRLRELCRRWLRPEARTKAQILELLVLEQFLSILPGEIRTWVQLHHPGSGEEAVALVEELQKDLDGPAIQVPVLVKDQDTLQKVVSAPGTTLPPVLPGSHIAAEICPHPPTDLVAFNLQDPQHDSPAPEASALSQEENPRNQLMALMLLTAQPQELVMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSLEWETMTENEEVTSKPSSSQRADSHKGTSKRLQGSVPQVLDFEEECEWQVLASQWGNETDERADTVKKVSLCERDKKKRTPPEKQGQKWKELGDSLTFGSAISESLIGTEGKKFYKCDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPYECDECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGKGFTYNRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCNECGKDFSQNKNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDEKPCECDVSEKEFSQTSNLHLQQKIHTIEEFSWLQNTNESKIEIQKI", "length": 1029 }, "evidence": [ { "id": "E1BKY0", "url": "https://omabrowser.org/oma/group/E1BKY0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BKY0", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1032, "end_pos": 1034, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 975, "end_pos": 977, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1041, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKY0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 373, "end_pos": 400, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 309, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKY0" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 127, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1032, "end_pos": 1034 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 749, "end_pos": 751 }, { "start_pos": 975, "end_pos": 977 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BKZ2-1", "uniprot_ac": "E1BKZ2", "uniprot_id": "E1BKZ2_BOVIN", "mass": { "chemical_mass": 67553.0, "monoisotopic_mass": 67553.0 }, "refseq": { "ac": "NP_001179044", "name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179044" }, "gene_names": [ { "name": "LRIT1", "type": "recommended", "evidence": [ { "id": "E1BKZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ] }, { "name": "LRIT1", "type": "synonym", "evidence": [ { "id": "NP_001179044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179044" } ] } ], "protein_names": [ { "name": "Leucine rich repeat, Ig-like and transmembrane domains 1", "type": "synonym", "evidence": [ { "id": "E1BKZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat, immunoglobulin-like and transmembrane domains 1", "type": "synonym", "evidence": [ { "id": "NP_001179044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179044" } ] }, { "name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179044" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRIT1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2", "locus": { "chromosome": "28", "start_pos": 39201718, "end_pos": 39213131, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003442", "url": "https://www.ensembl.org/id/ENSBTAG00000003442" } ] } } ], "crossref": [ { "id": "E1BKZ2", "url": "https://alphafold.ebi.ac.uk/entry/E1BKZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003442", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003442", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538858", "url": "https://www.ncbi.nlm.nih.gov/gene/538858", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538858", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538858", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IVCVCVK", "url": "https://omabrowser.org/oma/group/IVCVCVK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKZ2", "url": "https://www.orthodb.org/?gene=E1BKZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179044", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKZ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVVVGMLWLLALGGPPQAQGACPSQCSCSLHVLSDGSKARTVVCNDPDMTLPPASVPLDTSKLRLERTAIRRVPGDAFKTLGRLEQLWLPYNALCELSALMLRGLRRLRELRMPGNRLAAFPWAALRDAPQLRLLDLQANRLSAVPPEAARFLGNLTFLDLSSNQLLRLPQELLATWIHLHTGPFLPGHHARLVLGLQDNPWVCDCRLYDLVHFLEGWAPNLAFIEARLRCASPRSLAGVVFSQLELRKCQSPELHPGMTSIRSPLGSRVLLRCGATGVPGPEMSWSRANGHPLNGTVHQEVSSDGTSWALLGLPAVSQLDSGDYICQAKNFLGASETLISLVVTEPQTSTERSGGPGARWARTGEGAEAAAYNKMVARHVPHVPEPGVPATGPPVPNAKEQLFLQHFQMRPPEEHSDVPAGSHEAQTVSSLKVVGDTYQSVTLVWKAPQAGNTTALSVLYAVFGKRDMRRVLVQPGKTSVTIRGLVPKVKYVACVCVRGLVPRKEQCVIFSTDEVVDAEATQRLINVVVISVAAVIALPLTLLVCCGAVRRRWRKCHAGGSAEATGAYVNLERLGHSEDGSEDLSQHSLSEADRLLSARSSLDSQAVGIRASRRINEYFC", "length": 622, "header": "tr|E1BKZ2-1|E1BKZ2_BOVIN Isoform 1 of Leucine rich repeat, Ig-like and transmembrane domains 1 OS=Bos taurus OX=9913 GN=LRIT1 PE=4 SV=1 CANONICAL=E1BKZ2-1" }, "isoforms": [ { "isoform_ac": "E1BKZ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2/entry#E1BKZ2-1", "sequence": { "sequence": "MRVVVGMLWLLALGGPPQAQGACPSQCSCSLHVLSDGSKARTVVCNDPDMTLPPASVPLDTSKLRLERTAIRRVPGDAFKTLGRLEQLWLPYNALCELSALMLRGLRRLRELRMPGNRLAAFPWAALRDAPQLRLLDLQANRLSAVPPEAARFLGNLTFLDLSSNQLLRLPQELLATWIHLHTGPFLPGHHARLVLGLQDNPWVCDCRLYDLVHFLEGWAPNLAFIEARLRCASPRSLAGVVFSQLELRKCQSPELHPGMTSIRSPLGSRVLLRCGATGVPGPEMSWSRANGHPLNGTVHQEVSSDGTSWALLGLPAVSQLDSGDYICQAKNFLGASETLISLVVTEPQTSTERSGGPGARWARTGEGAEAAAYNKMVARHVPHVPEPGVPATGPPVPNAKEQLFLQHFQMRPPEEHSDVPAGSHEAQTVSSLKVVGDTYQSVTLVWKAPQAGNTTALSVLYAVFGKRDMRRVLVQPGKTSVTIRGLVPKVKYVACVCVRGLVPRKEQCVIFSTDEVVDAEATQRLINVVVISVAAVIALPLTLLVCCGAVRRRWRKCHAGGSAEATGAYVNLERLGHSEDGSEDLSQHSLSEADRLLSARSSLDSQAVGIRASRRINEYFC", "length": 622, "header": "tr|E1BKZ2-1|E1BKZ2_BOVIN Isoform 1 of Leucine rich repeat, Ig-like and transmembrane domains 1 OS=Bos taurus OX=9913 GN=LRIT1 PE=4 SV=1 CANONICAL=E1BKZ2-1" }, "locus": { "chromosome": "28", "start_pos": 39213131, "end_pos": 39201721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031291.3", "url": "https://www.ensembl.org/id/ENSBTAT00000031291.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031247.2", "url": "https://www.ensembl.org/id/ENSBTAP00000031247.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538858", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538858", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YAK6-1", "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "LRIT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWIAVSLLCCLVLGGLPPAGTSCPSQCSCAFHSLNEGTKARTVLCNDPEMTLTPVNIPVDTFKLRIEKTAIRRVPGEAFHALHNLEYLWLPYNSLASLSGITFKGLRRLLELRLDGNDLISFPWETLSDMPQLRLLDLHNNELTSIPPDAARYIKNITYLDLSSNKLMTLPQALISTWANLQAVPYFPNDNSKIILGLQDNPWACDCSLYEMVHFLNFQSPNIAFIEPRLKCFTPRSLAGVFFSQVELRKCQSPVVHTSVAKVKTILGSTVLLRCGTTGVPIPELSWRRADGAPLNGTVHQEISSDGMSWSILGLPVVSYLDSGEYICKAKNFLGATEAFISLIIMDSESTDDPNPNAKGTWSGKASGMEAAAYNDKLVARYVITTSTMPTLGAGAGTGEDVLIPAGAQDSNPQNLLVSPPTGQQEPERIVRSVRVIGDTDQSVTLAWKAPLAKNTTVFSVLYAVFGERDMRRINVEPGKTKVSIYGLLPKTKYIVCVCVKGLIPRKEQCIIFSTDEVASAGGTQKLINVVVISVACVIAVPLTLVVCCGALKRRCKKCFVRKPKEIQESYVTFESLSPGAKVKGVEGEYLTRHTPDESNRLLSARSSVDSEAIPKIEGQPNEYFC", "length": 626 }, "evidence": [ { "id": "E1BKZ2", "url": "https://omabrowser.org/oma/group/E1BKZ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8K099-1", "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "Lrit1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWVALGMLWLLALGGPHQAWGFCPSECSCSLRILSDGSKARTVVCSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGLRRLRELRLPGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLENLTFLDLSNNQLMRLPEELLDVWAHLKTGPFLSGHHARLILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVALATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSAEASGAYVNLERLGHSEDSSEVLSRSSLSEGDRLLSARSSLDSQVLGVRGGRRINEYFC", "length": 624 }, "evidence": [ { "id": "E1BKZ2", "url": "https://omabrowser.org/oma/group/E1BKZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JMH2-1", "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "Lrit1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWVALGMLWLLALGGPHQAWSFCPSQCSCSLHILSDGSKARTVVCSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSTLMLRGLRRLRELRLPGNHLVTFPWAALKDTPQLQLLDLQANRLSTLPPEAVHFLENLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLGLQDNPWVCDCRLYDLVHLLDGWASNLIFIEARLRCGSPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPSIKEELPLQNFQMDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGQRDMRRMTVEAGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRAGGSAEASGAYVNLERLGHSEDGSEELSRSSLSEADRLLSARSSLDSQVLGVRGGRRINEYFC", "length": 623 }, "evidence": [ { "id": "E1BKZ2", "url": "https://omabrowser.org/oma/group/E1BKZ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9P2V4-1", "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "LRIT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIALPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLSARSSVDFQAFGVKGGRRINEYFC", "length": 623 }, "evidence": [ { "id": "E1BKZ2", "url": "https://omabrowser.org/oma/group/E1BKZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "E1BKZ2", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BKZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 622, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BKZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BKZ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BKZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 429, "end_pos": 517, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BKZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKZ2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 254, "end_pos": 346, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 454, "end_pos": 456 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL05-1", "uniprot_ac": "E1BL05", "uniprot_id": "E1BL05_BOVIN", "mass": { "chemical_mass": 121967.0, "monoisotopic_mass": 121967.0 }, "refseq": { "ac": "XP_002700216", "name": "APC membrane recruitment protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700216" }, "gene_names": [ { "name": "AMER1", "type": "recommended", "evidence": [ { "id": "E1BL05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ] }, { "name": "AMER1", "type": "synonym", "evidence": [ { "id": "XP_002700216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700216" } ] } ], "protein_names": [ { "name": "APC membrane recruitment protein 1", "type": "synonym", "evidence": [ { "id": "XP_002700216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700216" }, { "id": "E1BL05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL05/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMER1", "url": "https://www.uniprot.org/uniprotkb/E1BL05", "locus": { "chromosome": "X", "start_pos": 96186478, "end_pos": 96119562, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008839", "url": "https://www.ensembl.org/id/ENSBTAG00000008839" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539029", "url": "https://www.ncbi.nlm.nih.gov/gene/539029", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539029", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539029", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BL05", "url": "https://www.orthodb.org/?gene=E1BL05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22237:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22237:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-196299", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002700216", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4S2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL05-1", "url": "https://www.uniprot.org/uniprotkb/E1BL05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METRKDEAAQAKGTTVSMDTQDQGTEKGAKNKASETTERPTSEPPSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAVHDPEDIVSEGTGLSLPLPESSCQLPSSQSVHGSLETDSRCKRSVAGATEKAGAEKAHFVPKPKKGLKGFFSSIRRHRKSKVSGAEQSNPGAKESEGARARPHEYVSSALLSHADEVLQAPRKENAKFQDVPGPNIPSISETSLAATEKAAFKDAEKTLEAFVSAFLQPKPAPEASGPEEFHSPETGEKLVAGEVNPPNGPLGDQLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEVELEEGEEVKEEEDDDLEYLWASSQMYPRPILNPGYHPTTSPGHLGYMLLDPVRSYPGSAPGELLTPQSDQQESAPNSDEGYYDSTTPGLEDDSGEALGLVHRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHCHSSEMFDPFLNFEPFSSPRPPGAMETEEERLVAIQKQLLYWELQREQREAREACAQEAHTREAHAREAHTREAYVREARPREAYAREACGQEVCGRELQVREAQVRQEKPVIEYQMRPLGPSVMGLVEGASGASQTSHRGTTSAFPATASSEPDWRDFRPLEKRFEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEEPEEEDVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYQKHAFNNYRSRFYQGLPWGVSSLPRYLGLPGMHPRPPPAAMALSRRSRSLDTAETLELELSNSHLTQGYMESDELQAQQEDSEEEEEEEEWGRDSPLSLYTEPPVTYDWPAWAPCPLPVGPGHAWISPSQLDGPSSHPFGQAVCCISPFTMSMLLSVSGPEPRAPGESKSQLARPSHLPLPMGPCYNLQPKASQSVRARPQDVLLPVDEPSCSSISGGFSPSPVPQAKPVGITHGIPQLPRIRPEPPEPQPIHYGASRLDLSKEKAEQGASLPTSCSSTAMNGKLAE", "length": 1119, "header": "tr|E1BL05-1|E1BL05_BOVIN Isoform 1 of APC membrane recruitment protein 1 OS=Bos taurus OX=9913 GN=AMER1 PE=3 SV=4 CANONICAL=E1BL05-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4S2-1", "url": "https://www.uniprot.org/uniprotkb/E1BL05/entry#A0AAA9S4S2-1", "sequence": { "sequence": "METRKDEAAQAKGTTVSMDTQDQGTEKGAKNKASETTERPTSEPPSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAVHDPEDIVSEGTGLSLPLPESSCQLPSSQSVHGSLETDSRCKRSVAGATEKAGAEKAHFVPKPKKGLKGFFSSIRRHRKSKVSGAEQSNPGAKESEGARARPHEYVSSALLSHADEVLQAPRKENAKFQDVPGPNIPSISETSLAATEKAAFKDAEKTLEAFVSAFLQPKPAPEASGPEEFHSPETGEKLVAGEVNPPNGPLGDQLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEVELEEGEEVKEEEDDDLEYLWASSQMYPRPILNPGYHPTTSPGHLGYMLLDPVRSYPGSAPGELLTPQSDQQESAPNSDEGYYDSTTPGLEDDSGEALGLVHRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHCHSSEMFDPFLNFEPFSSPRPPGAMETEEERLVAIQKQLLYWELQREQREAREACAQEAHTREAYVREARPREAYAREACGQEVCGRELQVREAQVRQEKPVIEYQMRPLGPSVMGLVEGASGASQTSHRGTTSAFPATASSEPDWRDFRPLEKRFEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEEPEEEDVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYQKHAFNNYRSRFYQGLPWGVSSLPRYLGLPGMHPRPPPAAMALSRRSRSLDTAETLELELSNSHLTQGYMESDELQAQQEDSEEEEEEEEWGRDSPLSLYTEPPVTYDWPAWAPCPLPVGPGHAWISPSQLDGPSSHPFGQAVCCISPFTMSMLLSVSGPEPRAPGESKSQLARPSHLPLPMGPCYNLQPKASQSVRARPQDVLLPVDEPSCSSISGGFSPSPVPQAKPVGITHGIPQLPRIRPEPPEPQPIHYGASRLDLSKEKAEQGASLPTSCSSTAMNGKLAE", "length": 1109, "header": "tr|A0AAA9S4S2-1|A0AAA9S4S2_BOVIN Computationally mapped isoform of APC membrane recruitment protein 1 OS=Bos taurus OX=9913 GN=AMER1 PE=3 SV=1 CANONICAL=E1BL05-1" }, "locus": { "chromosome": "X", "start_pos": 96144623, "end_pos": 96141267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099426.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099426.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078833.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078833.1" } ] } }, { "isoform_ac": "E1BL05-1", "url": "https://www.uniprot.org/uniprotkb/E1BL05/entry#E1BL05-1", "sequence": { "sequence": "METRKDEAAQAKGTTVSMDTQDQGTEKGAKNKASETTERPTSEPPSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAVHDPEDIVSEGTGLSLPLPESSCQLPSSQSVHGSLETDSRCKRSVAGATEKAGAEKAHFVPKPKKGLKGFFSSIRRHRKSKVSGAEQSNPGAKESEGARARPHEYVSSALLSHADEVLQAPRKENAKFQDVPGPNIPSISETSLAATEKAAFKDAEKTLEAFVSAFLQPKPAPEASGPEEFHSPETGEKLVAGEVNPPNGPLGDQLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEVELEEGEEVKEEEDDDLEYLWASSQMYPRPILNPGYHPTTSPGHLGYMLLDPVRSYPGSAPGELLTPQSDQQESAPNSDEGYYDSTTPGLEDDSGEALGLVHRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHCHSSEMFDPFLNFEPFSSPRPPGAMETEEERLVAIQKQLLYWELQREQREAREACAQEAHTREAHAREAHTREAYVREARPREAYAREACGQEVCGRELQVREAQVRQEKPVIEYQMRPLGPSVMGLVEGASGASQTSHRGTTSAFPATASSEPDWRDFRPLEKRFEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEEPEEEDVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYQKHAFNNYRSRFYQGLPWGVSSLPRYLGLPGMHPRPPPAAMALSRRSRSLDTAETLELELSNSHLTQGYMESDELQAQQEDSEEEEEEEEWGRDSPLSLYTEPPVTYDWPAWAPCPLPVGPGHAWISPSQLDGPSSHPFGQAVCCISPFTMSMLLSVSGPEPRAPGESKSQLARPSHLPLPMGPCYNLQPKASQSVRARPQDVLLPVDEPSCSSISGGFSPSPVPQAKPVGITHGIPQLPRIRPEPPEPQPIHYGASRLDLSKEKAEQGASLPTSCSSTAMNGKLAE", "length": 1119, "header": "tr|E1BL05-1|E1BL05_BOVIN Isoform 1 of APC membrane recruitment protein 1 OS=Bos taurus OX=9913 GN=AMER1 PE=3 SV=4 CANONICAL=E1BL05-1" }, "locus": { "chromosome": "X", "start_pos": 96169348, "end_pos": 96168854, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076120.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076120.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539029", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539029", "resource": "KEGG Pathway" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-196299", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "resource": "Reactome", "description": "Beta-catenin phosphorylation cascade" }, { "id": "R-BTA-4641262", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "resource": "Reactome", "description": "Disassembly of the destruction complex and recruitment of AXIN to the membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "beta-catenin destruction complex binding", "id": "GO:1904713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904713", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "regulation of canonical Wnt signaling pathway", "id": "GO:0060828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060828", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1BL05", "url": "https://www.uniprot.org/uniprotkb/E1BL05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 750, "end_pos": 752, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 750, "end_pos": 752 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL23-1", "uniprot_ac": "E1BL23", "uniprot_id": "E1BL23_BOVIN", "mass": { "chemical_mass": 47031.0, "monoisotopic_mass": 47031.0 }, "refseq": { "ac": "XP_003586340", "name": "kiSS-1 receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586340" }, "gene_names": [ { "name": "KISS1R", "type": "recommended", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ] }, { "name": "KISS1R", "type": "synonym", "evidence": [ { "id": "XP_003586340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586340" } ] } ], "protein_names": [ { "name": "KiSS-1 receptor", "type": "recommended", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 54", "type": "synonym", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor OT7T175", "type": "synonym", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#names_and_taxonomy" } ] }, { "name": "Kisspeptins receptor", "type": "synonym", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#names_and_taxonomy" } ] }, { "name": "Metastin receptor", "type": "synonym", "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#names_and_taxonomy" } ] }, { "name": "kiSS-1 receptor", "type": "synonym", "evidence": [ { "id": "XP_003586340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586340" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KISS1R", "url": "https://www.uniprot.org/uniprotkb/E1BL23", "locus": { "chromosome": "7", "start_pos": 43456613, "end_pos": 43452411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037418", "url": "https://www.ensembl.org/id/ENSBTAG00000037418" } ] } } ], "crossref": [ { "id": "E1BL23", "url": "https://alphafold.ebi.ac.uk/entry/E1BL23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037418", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037418", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15095", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15095", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528699", "url": "https://www.ncbi.nlm.nih.gov/gene/528699", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528699", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528699", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR45695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45695:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45695:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003586340", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586340", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXY0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXY0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL23-1", "url": "https://www.uniprot.org/uniprotkb/E1BL23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGINAQWLQLRIPGKLRPRLCSASPEGDPESHGSDRRVKSRRVVRTKRVAMQPLSASGPNASWWAPANTTVCPGCGANTSDGAIPAPWPVDAWLVPLFFGALMLLGLTGNSLVIFVICRHKQMRTVTNFYIANLAVTDLTFLLCCVPFTALLYPLPAWVLGDFMCKFLNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHQRTPRLALAVSLGIWVGSAVVSAPVFALHRLSSGPRTYCSEAFPSRALERAFALYNLLALYLLPLVATCACYGAMLRHLGRAAVRPAPAGGALEGQLMAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLLLQALGPAGAWHPRSYTAYALKIWAHCMSYCNSALNPLLYAFLGSHFRQAFRRVCPCAPRPLPRPWRPGPSDTAAVHQTQLRRLGHARPPEVRQR", "length": 429, "header": "tr|E1BL23-1|E1BL23_BOVIN Isoform 1 of KiSS-1 receptor OS=Bos taurus OX=9913 GN=KISS1R PE=4 SV=4 CANONICAL=E1BL23-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXY0-1", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#A0A3Q1MXY0-1", "sequence": { "sequence": "MRGINAQWLQLRIPGKLRPRLCSASPEGDPESHGSDRRVKSRRVVRTKRVAMQPLSASGPNASWWAPANTTVCPGCGANTSDGAIPAPWPVDAWLVPLFFGALMLLGLTGNSLVIFVICRHKQMRTVTNFYIANLAVTDLTFLLCCVPFTALLYPLPAWVLGDFMCKFLNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHQRTPRLALAVSLGIWVGAADGGAGGCRAGQGLEAGGGRGPALRCLLGPHPAVPAAAGAGPGRRLASAQLHRLRAQDLGTLHVLLQLGAEPTALRLPGLPLPPGLPPRLPLRSQAAPATLAAWTLGHCGRPPNPAATPGPRQAPRSQAAVVPGCACCAF", "length": 361, "header": "tr|A0A3Q1MXY0-1|A0A3Q1MXY0_BOVIN Computationally mapped isoform of KISS1 receptor OS=Bos taurus OX=9913 GN=KISS1R PE=4 SV=2 CANONICAL=E1BL23-1" }, "locus": { "chromosome": "7", "start_pos": 43455638, "end_pos": 43452610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073562.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073562.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060740.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060740.2" } ] } }, { "isoform_ac": "E1BL23-1", "url": "https://www.uniprot.org/uniprotkb/E1BL23/entry#E1BL23-1", "sequence": { "sequence": "MRGINAQWLQLRIPGKLRPRLCSASPEGDPESHGSDRRVKSRRVVRTKRVAMQPLSASGPNASWWAPANTTVCPGCGANTSDGAIPAPWPVDAWLVPLFFGALMLLGLTGNSLVIFVICRHKQMRTVTNFYIANLAVTDLTFLLCCVPFTALLYPLPAWVLGDFMCKFLNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHQRTPRLALAVSLGIWVGSAVVSAPVFALHRLSSGPRTYCSEAFPSRALERAFALYNLLALYLLPLVATCACYGAMLRHLGRAAVRPAPAGGALEGQLMAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLLLQALGPAGAWHPRSYTAYALKIWAHCMSYCNSALNPLLYAFLGSHFRQAFRRVCPCAPRPLPRPWRPGPSDTAAVHQTQLRRLGHARPPEVRQR", "length": 429, "header": "tr|E1BL23-1|E1BL23_BOVIN Isoform 1 of KiSS-1 receptor OS=Bos taurus OX=9913 GN=KISS1R PE=4 SV=4 CANONICAL=E1BL23-1" }, "locus": { "chromosome": "7", "start_pos": 43455609, "end_pos": 43452610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054521.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054521.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048078.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048078.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528699", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528699", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "pmid": "" }, { "name": "neuropeptide receptor activity", "id": "GO:0008188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008188", "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "pmid": "" }, { "name": "positive regulation of hormone secretion", "id": "GO:0046887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046887", "evidence": [ { "database": "UniProtKB", "id": "E1BL23", "url": "https://www.uniprot.org/uniprotkb/E1BL23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL23-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 429, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL23-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL23" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL23" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 374, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 }, { "start_pos": 69, "end_pos": 71 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL33-1", "uniprot_ac": "E1BL33", "uniprot_id": "E1BL33_BOVIN", "mass": { "chemical_mass": 119963.0, "monoisotopic_mass": 119963.0 }, "refseq": {}, "gene_names": [ { "name": "NLRP8", "type": "recommended", "evidence": [ { "id": "E1BL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL33" } ] } ], "protein_names": [ { "name": "NLR family pyrin domain containing 8", "type": "synonym", "evidence": [ { "id": "E1BL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL33/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL33", "url": "https://www.uniprot.org/uniprotkb/E1BL33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NLRP8", "url": "https://www.uniprot.org/uniprotkb/E1BL33", "locus": { "chromosome": "18", "start_pos": 63472863, "end_pos": 63453433, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006965", "url": "https://www.ensembl.org/id/ENSBTAG00000006965" } ] } } ], "crossref": [ { "id": "E1BL33", "url": "https://alphafold.ebi.ac.uk/entry/E1BL33", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006965", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006965", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08320", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08320", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BL33", "url": "https://www.orthodb.org/?gene=E1BL33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BL33", "url": "https://www.uniprot.org/uniprotkb/E1BL33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL33-1", "url": "https://www.uniprot.org/uniprotkb/E1BL33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDMNLSSDPSSCPSSPLSPSGVSPPSLESSSSSTLPFRNGVMPFMLSVSAEHLQRFKQLLVEENPRPGCSPLTWDQLKSARCGELVHLLTEYFPGQRAWEMARDIFAKMNQTELCLQTQRELNEILPNLEPEALSLRKRELTLEEDESDKIREYKARVMSEHSTLWDRTSWPGNNVDFFYQEPCREDTLLQCLLLPRKPQGRQPKTVVLQGDAGVGKTTVAKKVMQQWAENKFYAHKGWLAFYLHCQEMDRPEEQSFSELIACKLSGSPALASRILSHPEHLLLLLDGFEELTLTLIDRREDLSEDWSQKMPGSVLLTSLLSKRMLPDATIIVFLRFSLWKTVGPFLNSPSLITLMGFSAPERSRYFRSYFKNRRDADAALRFAMGNAVLFSMCRVPVICWLVCSCLKQQMERGSSLPRAFPNATAVFIHYLSSLLPTRVRHVVGETPQEQLKRLCSLAVEGMWKNQWVFSEMDLKLARLDDRDVEVFLGVRVLRRAVAGGDLIAFAHPSFQEFFAALLFVLCFPQRLRNFQVLDRFRIFQLLAHPGRRKNHLAGMALFLFGLLNDTCALAVEQLFGCKVSLGNKRKLLKVATMPPDGDPLTPQHGLPQLFYCLHEIREEVFVGQILHNHRKALLVISKIRDLQVSAFCLKFCRQLRELEVTISWAVAKATSLSPGPLPSPQPEGSDLRSLWWQDFCSVFKTHESLEVLTVRDSVMDTEAVETLAAALRHPHCNLRKLIFKRVGSLVVSEGIIRVLVENQYLRHLEIQDTEVGCQVIDALCNTLKHPWCFLQFLRLEGCPFDPSNGADLTRSLKRNIHLKTLMLRRGSLERGEECPPVLAPQLERLSLENCDLTPLSCESLAFSLVSNQSLTHLSLAENALQDDGVKQLWNILQHFPCPLQRLVLRNCALTSECCQDIASALDKNKTLRSLDLGANRLRDSGVVLLCQPLLNPDSGLQVLELEECQFTSICCPALTSVLLHNRTLRYLDLSGNGVGLQGAKLLQDAALKRVLRPEVVLKKKQSNGVDMMRRLEGPVVNKDILKMVQDWKDEFCDQAAGMV", "length": 1061, "header": "tr|E1BL33-1|E1BL33_BOVIN Isoform 1 of NLR family pyrin domain containing 8 OS=Bos taurus OX=9913 GN=NLRP8 PE=3 SV=4 CANONICAL=E1BL33-1" }, "isoforms": [ { "isoform_ac": "E1BL33-1", "url": "https://www.uniprot.org/uniprotkb/E1BL33/entry#E1BL33-1", "sequence": { "sequence": "MGDMNLSSDPSSCPSSPLSPSGVSPPSLESSSSSTLPFRNGVMPFMLSVSAEHLQRFKQLLVEENPRPGCSPLTWDQLKSARCGELVHLLTEYFPGQRAWEMARDIFAKMNQTELCLQTQRELNEILPNLEPEALSLRKRELTLEEDESDKIREYKARVMSEHSTLWDRTSWPGNNVDFFYQEPCREDTLLQCLLLPRKPQGRQPKTVVLQGDAGVGKTTVAKKVMQQWAENKFYAHKGWLAFYLHCQEMDRPEEQSFSELIACKLSGSPALASRILSHPEHLLLLLDGFEELTLTLIDRREDLSEDWSQKMPGSVLLTSLLSKRMLPDATIIVFLRFSLWKTVGPFLNSPSLITLMGFSAPERSRYFRSYFKNRRDADAALRFAMGNAVLFSMCRVPVICWLVCSCLKQQMERGSSLPRAFPNATAVFIHYLSSLLPTRVRHVVGETPQEQLKRLCSLAVEGMWKNQWVFSEMDLKLARLDDRDVEVFLGVRVLRRAVAGGDLIAFAHPSFQEFFAALLFVLCFPQRLRNFQVLDRFRIFQLLAHPGRRKNHLAGMALFLFGLLNDTCALAVEQLFGCKVSLGNKRKLLKVATMPPDGDPLTPQHGLPQLFYCLHEIREEVFVGQILHNHRKALLVISKIRDLQVSAFCLKFCRQLRELEVTISWAVAKATSLSPGPLPSPQPEGSDLRSLWWQDFCSVFKTHESLEVLTVRDSVMDTEAVETLAAALRHPHCNLRKLIFKRVGSLVVSEGIIRVLVENQYLRHLEIQDTEVGCQVIDALCNTLKHPWCFLQFLRLEGCPFDPSNGADLTRSLKRNIHLKTLMLRRGSLERGEECPPVLAPQLERLSLENCDLTPLSCESLAFSLVSNQSLTHLSLAENALQDDGVKQLWNILQHFPCPLQRLVLRNCALTSECCQDIASALDKNKTLRSLDLGANRLRDSGVVLLCQPLLNPDSGLQVLELEECQFTSICCPALTSVLLHNRTLRYLDLSGNGVGLQGAKLLQDAALKRVLRPEVVLKKKQSNGVDMMRRLEGPVVNKDILKMVQDWKDEFCDQAAGMV", "length": 1061, "header": "tr|E1BL33-1|E1BL33_BOVIN Isoform 1 of NLR family pyrin domain containing 8 OS=Bos taurus OX=9913 GN=NLRP8 PE=3 SV=4 CANONICAL=E1BL33-1" }, "locus": { "chromosome": "18", "start_pos": 63472012, "end_pos": 63455458, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054525.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054525.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048061.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048061.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BL33", "url": "https://www.uniprot.org/uniprotkb/E1BL33" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BL33", "url": "https://www.uniprot.org/uniprotkb/E1BL33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "E1BL33", "url": "https://www.uniprot.org/uniprotkb/E1BL33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 869, "end_pos": 871, "annotation": "n_glycosylation_sequon" }, { "start_pos": 926, "end_pos": 928, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL33-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1061, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL33-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL33" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL33" }, { "id": "PS50837", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50837" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NACHT", "eco_id": "ECO_0000259", "start_pos": 206, "end_pos": 410, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL33" }, { "id": "PS50824", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50824" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pyrin", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 125, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 869, "end_pos": 871 }, { "start_pos": 926, "end_pos": 928 }, { "start_pos": 983, "end_pos": 985 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL45-1", "uniprot_ac": "E1BL45", "uniprot_id": "E1BL45_BOVIN", "mass": { "chemical_mass": 153698.0, "monoisotopic_mass": 153698.0 }, "refseq": { "ac": "NP_001341648", "name": "EH domain-binding protein 1-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341648" }, "gene_names": [ { "name": "EHBP1L1", "type": "recommended", "evidence": [ { "id": "E1BL45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ] }, { "name": "EHBP1L1", "type": "synonym", "evidence": [ { "id": "NP_001341648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341648" } ] } ], "protein_names": [ { "name": "EH domain binding protein 1 like 1", "type": "synonym", "evidence": [ { "id": "E1BL45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL45/entry#names_and_taxonomy" } ] }, { "name": "EH domain-binding protein 1-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001341648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341648" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EHBP1L1", "url": "https://www.uniprot.org/uniprotkb/E1BL45", "locus": { "chromosome": "29", "start_pos": 43774075, "end_pos": 43758719, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009554", "url": "https://www.ensembl.org/id/ENSBTAG00000009554" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009554", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009554", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21255", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21255", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788760", "url": "https://www.ncbi.nlm.nih.gov/gene/788760", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788760", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788760", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WQKTSAQ", "url": "https://omabrowser.org/oma/group/WQKTSAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BL45", "url": "https://www.orthodb.org/?gene=E1BL45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10358", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10358", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001341648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL45-1", "url": "https://www.uniprot.org/uniprotkb/E1BL45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSVWKRLQRVGKRAAKFQFVACYHELVVECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFIIENESKGQRKVLATAEVDLARHAGPVPTQVPLRLRLKPKSVKVVQAELSLTLSGVLLREGRATDDDMQSLASLMSMKPSDVGNLDDFAESDEEEANGPGALEARTRVPQPETPRELKTLCEEEEEGRLQPRQAAASPSSAEDTSPAPVSAPAPPARASRGQGSEPATVAGGQVGLKASRPPGTLPETRPSRQPGQDMAPTPAPRLQKGSDAPWPPVHQGEDEAPKASGAPPAGVDSAVETQARASPQEGTEAQGAGLGPGIENRDSSNSLEGQKPKVEEGGAGDRAEASGVDTGHGPGVREVNSQRSVVRAGEAEESLEIDHVDVEQRSKVKPVDTKGPEATEVTSEARFKGTPEAPPRGSQGRTGVKTRDEAPTVLSPTPEEPVGHSGHLGDLKVARAAAGQERECAEVRGGAPGVGGTGLEQGPSAGAPSAGPQVSWYEGAPPAAEQGVMSRDLRVWEVETGDSSVLGTEPGVAESELLGTQEISGSPEIVSEVAEAKTLGTQETEAVRSGVLESEAAEMAESEDLGTQKTGVSISGASGTEGGMAECKELGTQETEAGGSGVLRTKTGMLEIKMLGTQEISGCSGILRREAETAESEILGAQDTEVGCSGVSEIKSKITGSQETEVGSSGVPGTETEVAEAEILGIQEIEAGGSGAPEMEAETLRTQETEVGDSGFAGSEAGMAEAEGLGNQQTETTVLEAEKGKAQTSGVQEAETGLGETLKYEALGVPVVKHEVLESQGTEAETTVSRGQEADTGIWGVSEAKSGVWGAREAEMEVSGASENPSGIFEAQEAEAGVSGAEKGKEAEGNLPEASLMEVQVASGAGAGVSRPSGASSPEEPEEDRRLPGSQAPPAQVSFSQSLLEWCQEVTAGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDFASLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGTGTYRVASAQPSPPDDLDTGGLAQRLREHRAEAPQQPQEAATRVDGAASEAASKDRGAVAAQEARSTEAPADGPGARASVPPAEGLVNGVGTPGAAGGVRLRRPSVNAEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSGDEPDSGAAGAAAEGTSPDPSPAPGLPAASAPQQPSGGTPPAEEPPPSPGEDSGLQRFQDTSQYVCAELQALEQEQRQIDGRAAEVEKQLRSLMESGTDRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEDWLKTAAQQRREQLLLEELVSLVNQRDELVRNLDQKERTALEEDERLERGLEQRRRKLSRQLGRRERCVLS", "length": 1450, "header": "tr|E1BL45-1|E1BL45_BOVIN Isoform 1 of EH domain binding protein 1 like 1 OS=Bos taurus OX=9913 GN=EHBP1L1 PE=4 SV=3 CANONICAL=E1BL45-1" }, "isoforms": [ { "isoform_ac": "E1BL45-1", "url": "https://www.uniprot.org/uniprotkb/E1BL45/entry#E1BL45-1", "sequence": { "sequence": "MTSVWKRLQRVGKRAAKFQFVACYHELVVECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFIIENESKGQRKVLATAEVDLARHAGPVPTQVPLRLRLKPKSVKVVQAELSLTLSGVLLREGRATDDDMQSLASLMSMKPSDVGNLDDFAESDEEEANGPGALEARTRVPQPETPRELKTLCEEEEEGRLQPRQAAASPSSAEDTSPAPVSAPAPPARASRGQGSEPATVAGGQVGLKASRPPGTLPETRPSRQPGQDMAPTPAPRLQKGSDAPWPPVHQGEDEAPKASGAPPAGVDSAVETQARASPQEGTEAQGAGLGPGIENRDSSNSLEGQKPKVEEGGAGDRAEASGVDTGHGPGVREVNSQRSVVRAGEAEESLEIDHVDVEQRSKVKPVDTKGPEATEVTSEARFKGTPEAPPRGSQGRTGVKTRDEAPTVLSPTPEEPVGHSGHLGDLKVARAAAGQERECAEVRGGAPGVGGTGLEQGPSAGAPSAGPQVSWYEGAPPAAEQGVMSRDLRVWEVETGDSSVLGTEPGVAESELLGTQEISGSPEIVSEVAEAKTLGTQETEAVRSGVLESEAAEMAESEDLGTQKTGVSISGASGTEGGMAECKELGTQETEAGGSGVLRTKTGMLEIKMLGTQEISGCSGILRREAETAESEILGAQDTEVGCSGVSEIKSKITGSQETEVGSSGVPGTETEVAEAEILGIQEIEAGGSGAPEMEAETLRTQETEVGDSGFAGSEAGMAEAEGLGNQQTETTVLEAEKGKAQTSGVQEAETGLGETLKYEALGVPVVKHEVLESQGTEAETTVSRGQEADTGIWGVSEAKSGVWGAREAEMEVSGASENPSGIFEAQEAEAGVSGAEKGKEAEGNLPEASLMEVQVASGAGAGVSRPSGASSPEEPEEDRRLPGSQAPPAQVSFSQSLLEWCQEVTAGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDFASLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGTGTYRVASAQPSPPDDLDTGGLAQRLREHRAEAPQQPQEAATRVDGAASEAASKDRGAVAAQEARSTEAPADGPGARASVPPAEGLVNGVGTPGAAGGVRLRRPSVNAEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSGDEPDSGAAGAAAEGTSPDPSPAPGLPAASAPQQPSGGTPPAEEPPPSPGEDSGLQRFQDTSQYVCAELQALEQEQRQIDGRAAEVEKQLRSLMESGTDRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEDWLKTAAQQRREQLLLEELVSLVNQRDELVRNLDQKERTALEEDERLERGLEQRRRKLSRQLGRRERCVLS", "length": 1450, "header": "tr|E1BL45-1|E1BL45_BOVIN Isoform 1 of EH domain binding protein 1 like 1 OS=Bos taurus OX=9913 GN=EHBP1L1 PE=4 SV=3 CANONICAL=E1BL45-1" }, "locus": { "chromosome": "29", "start_pos": 43773653, "end_pos": 43758770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008891.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008891.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008891.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008891.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1264, "start_aa": "Thr", "end_pos": 1264, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1264", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 301, "start_aa": "Thr", "end_pos": 301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 481, "start_aa": "Thr", "end_pos": 481, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr481", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:788760", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788760", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZY32-1", "protein_name": "EH domain binding protein 1-like 1", "gene_name": "Ehbp1l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFIIENESKGQRKVLATVDVNLAQHAGPVPAQVPLRLRLKPKSVKVVHAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEEEANGPGAPEVRAGGPQSGRGCALRLGRFPDRSRELKTLCEEEDEGHIQPQQAAARPSSAEDTSCAPVSAPAPLARAFRGQGSEPAAIAGGQVGPETPRPPPSPPETRSTGQPDQNMVPTPAPRLRKGSDAPWSPVPCRGDEIPNTSEDPPTGMGSSGETQTQISSQKGTEAHGARPEPDIEVRGSKDDLGGDRSKVEEGDTGDMPGPSGAENREKGTKKSYTTAGEAEESSKRHQVDAEQKSKVQHRATEGPEAAGLVPKARPGETPEAPPRSAQRRMGVRTQEEAPSDLNPPPAEPEEHLGDLRDARPAGQEKESTEVRGRAPAIGRTGLEQGPSAGAAGAGPQVSCFQGVPSVGQGVVSRDQKAQEAEVGEPRVLETEAEWVPWEVIGTPETNAGSLESPDIETGTAKSEILKAQESEAARSEVLESEATGTAESEVLRTQDKEIVVLGMLRTGAEIREPKEFGIQKTEVGGSAVPDTKTVTAETKTLEAQGIADGGACVLKIQAEVLGTQKTEAGEAETGILQTRKVAAEGWQAPVVEAEMVESDELGMQETEVEIGRIPRVETETAGTETLGVHRIAFEDSGSPQMQSTIVGDQEIDVSVTETAEDAILGTQELAAGHGVLVIEAELPESKIDRSLETEERGLGVLDTGTAETKISGTPERAPGVCKVLGIGAEVARVLEEEAGSSEVPETEAEETETRGAKELCGSSAALRVVSGRPESKILGAQKTEVGGTGLSQAEVRGTESEISSEGSGGPELEDKLEESEILGAQERKTEARELSEVETVNPQFTGTQKDLEITESEAKTVKSGIPEAQETEAKTAWTQEIEPGDAGVSRPEAEAPRAQWTEPIVLESGEVKTDILGVQKPGAWGALKCEALGVPMTKQGFSGAKEVVPEVSRVQEPETKVLGIEEAKSWTLGQQKAEREGFESPENKSDIFEAQETESGVLGTMKGKEADESLKEASLNKAQVASEAGAGVPRPSGASSPEEPEEDRRLPGSQAPSALVSSSQSLLEWCQEVTKGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGNAQPSLPDCLNAGDLAQRLREHGAEASTEPKEAVNRGTGAIPKVASRDTDLGSSSKDGEAEVAQEAVPQEASSDGPRARSSTSPVVPTEGLVNGVGAPASVSGVRLRRSSVNGEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSNSFSVDDQDSGTAVGAGPAGSGAVEGPNPDSSLDSGTLTATAPQQPPSGNPPTEESSPNPGEEAGQQRFQDTSQYVCAELQALEQEQGQIDGRAAEVEKQLRSLMESGANRLQEELLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEEWQKTVAQQHREQLLLEELVSLVNQRDELVRDLDQKERIALEEDERLERGLEQRRRKVSRQLSRRERCTLS", "length": 1711 }, "evidence": [ { "id": "E1BL45", "url": "https://omabrowser.org/oma/group/E1BL45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N3D4-1", "protein_name": "EH domain-binding protein 1-like protein 1", "gene_name": "EHBP1L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFIIENESKGQRKVLATAEVDLARHAGPVPVQVPVRLRLKPKSVKVVQAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEDEAHGPGAPEARARVPQPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAPAPPARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALEKEAARSRVLESEVAGTAQCEGLETQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLKIEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGSGISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVGSALKYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLRVQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEGSLTEASLPEAQVASGAGAGAPRASSPEKAEEDRRLPGSQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGPQEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQALEQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQQHREQLLLEELVSLVNQRDELVRDLDHKERIALEEDERLERGLEQRRRKLSRQLSRRERCVLS", "length": 1523 }, "evidence": [ { "id": "E1BL45", "url": "https://omabrowser.org/oma/group/E1BL45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99MS7-1", "protein_name": "EH domain-binding protein 1-like protein 1", "gene_name": "Ehbp1l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFIIENESKGQRKVLATVDVNLAHHAGPVPAQVPLRLRLKPKSVKVVHAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEEEANGPGAPEVRTRGPQSDLSRELKTLCEEEDEGHIRPQQAAARPSSAEDTSPAPVSAPAPPVRAFRGQGSEPAAITGGQVGPETPEPPPSPPETRSTGQPGQTMVPTPAPRLRKGSDAPSSPVPCSGDEVPNTSEDPPTGMGSSGETQAQISSQEGTEAHEARPEPDIEVRGSKDSLGGERSKVEEEERGDGPGASGTGNREKNTKKSDTTAGEAGESSELHQVDAEHKSKVQHRATEGPEAAGLTPKARLGDTPEAPPRSAQRRMGVRTQEEAPSDLNPPPAEPEEHLGDLRDARPAGQEKGSAEVRSKVPAIGRAGPEQGSSARAASAGPQVSCVQTVPSDGQGVKSRDQRAQEAEVGESRVLETEAEWVPWEVIGTSKTDAGIPESLDTEAGTAESEILEAQESEAARSEGLEPEAAGTAESEVLRTQNNEIVVLGMPRTGPEIREPEEFGETEVGGFTVPDTKTVIAETEILETQGVVDGEAAVLKTQAEISETQKTEAGEAEAGTLESQKVAAEGLGAPEVGAEMAEAEKLGVQETEVEIWRIPRIETETAGTETLGIHKIGPPQMQPRLVGDQETDVSVMETAEDAILGTREITAGCGVLLIEAKIPESKIDRSLETEEGDLGVLEVDTGIAEAKILGIPERAPGVQKALGAGTEVARVLEAEAASSEVPETDAEEAETLQAKERSESSVALRVVANLPESELLGTQKTEVGGTGISQREVREAETEIPKTQEISSEGSGVPDLEAKMEESGRKMEIWETPEVEKVNSELFGTQKGSEIPELETKTIKSEILDAQETEVRDLGLRRGEAEKAEAEMLETQKMEAKTARDEEIELVDPGVSSPEAEALRVQWAGTVVLESGEVKADILGVQKPGSWGALKYEALDVPVTKQRLSGAKEVVPEVPRAQEPETKVLGIVEAKSWTLGQQEAEMEGFESPENKSNIFEAQEADSGVLGTMKGKEAVESLEEAGLSKAQVASEAGAGVPRPSGASSLEEPEEDRRLPGSQAPPTLVSSSQSLLEWCQEVTNGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGNAQPSLPDCLDAGDLAQRLREHGAEVPTEPKEAVNRGTGAIPKVASRDTDLSCSSKDGEAEVAQEAIPQEAPTDGPRARSSTTPVVPAEGLVNGVGASGGVRLRRSSVNGEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSNSFSVDDQDSGAAVGAGPAGPGAVEGPNPASSPDANPLPAPVPQQPPGGPPPTEESSPSLGEEAGLQRFQDTSQYVCAELQALEQEQGQIDGRAAEVEKQLRSLMESGANRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEEWQKTVAQQHREQLLLEELVSLVNQRDELVRDLDQKERIALEEDERLERGLEQRRRKVSRQLSRRERCTLS", "length": 1716 }, "evidence": [ { "id": "E1BL45", "url": "https://omabrowser.org/oma/group/E1BL45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "E1BL45", "url": "https://www.uniprot.org/uniprotkb/E1BL45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1220, "end_pos": 1222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 985, "end_pos": 987, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL45" }, { "id": "PS51848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BMERB", "eco_id": "ECO_0000259", "start_pos": 1276, "end_pos": 1428, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BL45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL45" }, { "id": "PS51840", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 NT-type", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 157, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BL45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL45" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 961, "end_pos": 1066, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 301, 481, 1264 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 1220, "end_pos": 1222 }, { "start_pos": 985, "end_pos": 987 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL74-1", "uniprot_ac": "E1BL74", "uniprot_id": "E1BL74_BOVIN", "mass": { "chemical_mass": 31856.0, "monoisotopic_mass": 31856.0 }, "refseq": { "ac": "XP_010819550", "name": "tetraspanin-32 isoform X8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819550" }, "gene_names": [ { "name": "TSPAN32", "type": "recommended", "evidence": [ { "id": "E1BL74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL74" } ] }, { "name": "TSPAN32", "type": "synonym", "evidence": [ { "id": "XP_010819550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819550" } ] } ], "protein_names": [ { "name": "Tetraspanin-32", "type": "recommended", "evidence": [ { "id": "E1BL74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL74/entry#names_and_taxonomy" } ] }, { "name": "Protein Phemx", "type": "synonym", "evidence": [ { "id": "E1BL74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL74/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-32 isoform X8", "type": "synonym", "evidence": [ { "id": "XP_010819550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819550" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL74", "url": "https://www.uniprot.org/uniprotkb/E1BL74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN32", "url": "https://www.uniprot.org/uniprotkb/E1BL74", "locus": { "chromosome": "29", "start_pos": 49265271, "end_pos": 49282079, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002702", "url": "https://www.ensembl.org/id/ENSBTAG00000002702" } ] } } ], "crossref": [ { "id": "E1BL74", "url": "https://alphafold.ebi.ac.uk/entry/E1BL74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002702", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002702", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03153", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03153", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530507", "url": "https://www.ncbi.nlm.nih.gov/gene/530507", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530507", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530507", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WAFCTSI", "url": "https://omabrowser.org/oma/group/WAFCTSI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4P5", "url": "https://www.orthodb.org/?gene=A0A3Q1M4P5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BL74", "url": "https://www.orthodb.org/?gene=E1BL74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010819550", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL74", "url": "https://www.uniprot.org/uniprotkb/E1BL74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL74-1", "url": "https://www.uniprot.org/uniprotkb/E1BL74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPCSRVRVAKCQMLATSLFVLLLGSAMAATAALSYFGPHFTVIGPVSADRTTYEALHHWAFSAGIALAALLTLGAMLSAAATVRGAGGLMAAAFLSFALVFCALVQAAFWRAHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLCQGEEAARQDCLRGIQSFLRVHGNIVSTLIGLGLAFTVYAMLLSSFIWFTIRLGRYPVSQRARDHPPQEPRVYRCIREGSPSPRPSKADAPGGRLSPSRRSGQLLLLQDTHPPTHGSGEATVSTRM", "length": 298, "header": "tr|E1BL74-1|E1BL74_BOVIN Isoform 1 of Tetraspanin-32 OS=Bos taurus OX=9913 GN=TSPAN32 PE=3 SV=3 CANONICAL=E1BL74-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4P5-1", "url": "https://www.uniprot.org/uniprotkb/E1BL74/entry#A0A3Q1M4P5-1", "sequence": { "sequence": "MEPCSRVRVAKCQMLATSLFVLLLGSAMAATAALSYFGPHFTVIGPVSADRTTYEALHHWAFSAGIALAALLTLGAMLSAAATVRGAGGLMAAAFLSFALVFCALVQAAFWRAHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTDCLRGIQSFLRVHGNIVSTLIGLGLAFTVYAMLLSSFIWFTIRLGRYPVSQRARDHPPQEPRVYRCIREGSPSPRPSKADAPGGRLSPSRRSGQLLLLQDTHPPTHGSGEATVSTRM", "length": 269, "header": "tr|A0A3Q1M4P5-1|A0A3Q1M4P5_BOVIN Computationally mapped isoform of Tetraspanin 32 OS=Bos taurus OX=9913 GN=TSPAN32 PE=4 SV=1 CANONICAL=E1BL74-1" }, "locus": { "chromosome": "29", "start_pos": 49282057, "end_pos": 49266284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077028.1", "url": "https://www.ensembl.org/id/ENSBTAT00000077028.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068565.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068565.1" } ] } }, { "isoform_ac": "E1BL74-1", "url": "https://www.uniprot.org/uniprotkb/E1BL74/entry#E1BL74-1", "sequence": { "sequence": "MEPCSRVRVAKCQMLATSLFVLLLGSAMAATAALSYFGPHFTVIGPVSADRTTYEALHHWAFSAGIALAALLTLGAMLSAAATVRGAGGLMAAAFLSFALVFCALVQAAFWRAHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLCQGEEAARQDCLRGIQSFLRVHGNIVSTLIGLGLAFTVYAMLLSSFIWFTIRLGRYPVSQRARDHPPQEPRVYRCIREGSPSPRPSKADAPGGRLSPSRRSGQLLLLQDTHPPTHGSGEATVSTRM", "length": 298, "header": "tr|E1BL74-1|E1BL74_BOVIN Isoform 1 of Tetraspanin-32 OS=Bos taurus OX=9913 GN=TSPAN32 PE=3 SV=3 CANONICAL=E1BL74-1" }, "locus": { "chromosome": "29", "start_pos": 49282057, "end_pos": 49266284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003500.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003500.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003500.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003500.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530507", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530507", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ARQ4-1", "protein_name": "Tetraspanin", "gene_name": "TSPAN32", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPWSRVRAAKCQMLVTSLFVLLLGLAVATMAALTYFGAPLAVISHASRERTPFEALHRRAFFAGTGLAGLLALGAVLSSAATVREARGLMAGAFLCFALAFCALVQVTFWRFHDPTQVEDAVLDTYDLVFDRAVKNLSGIWRQELAAIQDTFLCCGKSSPLGLQGSSGADLCQGEGPARQDCLQGLRSFLRNHGNVVSTLTSLGLVSMVYAVLLSAFLCFAIHSGRSLDRKGKYTLSPRASGRQPQEPSFFRCCQEGPAPRHPPEADVCEARPGPSRCLRASFLLQDTKPPTHGGGSDTAALART", "length": 306 }, "evidence": [ { "id": "E1BL74", "url": "https://omabrowser.org/oma/group/E1BL74/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LD47-1", "protein_name": "Tetraspanin", "gene_name": "Tspan32", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGHWNRIKIAKCQILITNFFVLLLGLSLATMTVVTHFGDHFTVIGHASLQRNPYETLRYWAFYVGISLAGLLSLGAALSTIATVREAHGLMAAGFLCFALSFCILVQVAFWRFHNPTQVEDAVLDTYDLVYDQAMKSPSSSWWQELAVIQDTFLCCGKKSPFGLLASTGPIMCQGQKAMREDCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWFAIHSYCGLDRRGRYSLTPRSHGCQPQEPSLF", "length": 252 }, "evidence": [ { "id": "E1BL74", "url": "https://omabrowser.org/oma/group/E1BL74/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96QS1-1", "protein_name": "Tetraspanin-32", "gene_name": "TSPAN32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPWSRVRVAKCQMLVTCFFILLLGLSVATMVTLTYFGAHFAVIRRASLEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAAATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAAREDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSFLWFAIRCGCSLDRKGKYTLTPRACGRQPQEPSLLRCSQGGPTHCLHSEAVAIGPRGCSGSLRWLQESDAAPLPLSCHLAAHRALQGRSRGGLSGCPERGLSD", "length": 320 }, "evidence": [ { "id": "E1BL74", "url": "https://omabrowser.org/oma/group/E1BL74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHH2-1", "protein_name": "Tetraspanin-32", "gene_name": "Tspan32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGHWNRIKIAKCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERNPYETLRYWAFYVGISLAGLLSLGAALSTIATVREAHGLMAAGFLCFALSFCILVQVAFWRFYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREDCLQSIRNVLWTHYSIASILTCTSLALTVYAMMLCAFLWFAIHSYHGLDRKGRYSLTPPRSHGFQTQEPSLFRWT", "length": 256 }, "evidence": [ { "id": "E1BL74", "url": "https://omabrowser.org/oma/group/E1BL74/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BL74", "url": "https://www.uniprot.org/uniprotkb/E1BL74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell communication", "id": "GO:0007154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007154", "evidence": [ { "database": "UniProtKB", "id": "E1BL74", "url": "https://www.uniprot.org/uniprotkb/E1BL74" } ], "pmid": "" }, { "name": "signaling", "id": "GO:0023052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023052", "evidence": [ { "database": "UniProtKB", "id": "E1BL74", "url": "https://www.uniprot.org/uniprotkb/E1BL74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL74-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 298, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL74-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL74" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL80-1", "uniprot_ac": "E1BL80", "uniprot_id": "E1BL80_BOVIN", "mass": { "chemical_mass": 87812.0, "monoisotopic_mass": 87812.0 }, "refseq": { "ac": "NP_001179132", "name": "52 kDa repressor of the inhibitor of the protein kinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179132" }, "gene_names": [ { "name": "THAP12", "type": "recommended", "evidence": [ { "id": "E1BL80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ] }, { "name": "THAP12", "type": "synonym", "evidence": [ { "id": "NP_001179132", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179132" } ] } ], "protein_names": [ { "name": "52 kDa repressor of the inhibitor of the protein kinase", "type": "synonym", "evidence": [ { "id": "NP_001179132", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179132" } ] }, { "name": "THAP domain containing 12", "type": "synonym", "evidence": [ { "id": "E1BL80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL80/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THAP12", "url": "https://www.uniprot.org/uniprotkb/E1BL80", "locus": { "chromosome": "15", "start_pos": 55761481, "end_pos": 55791234, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031609", "url": "https://www.ensembl.org/id/ENSBTAG00000031609" } ] } } ], "crossref": [ { "id": "E1BL80", "url": "https://alphafold.ebi.ac.uk/entry/E1BL80", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508969", "url": "https://www.ncbi.nlm.nih.gov/gene/508969", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508969", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508969", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCSKAQQ", "url": "https://omabrowser.org/oma/group/YCSKAQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BL80", "url": "https://www.orthodb.org/?gene=E1BL80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46289:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46289:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05699", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05699", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179132", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL80-1", "url": "https://www.uniprot.org/uniprotkb/E1BL80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNFCAAPNCTRKSTQSDLAFFRFPRDPTRCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEPKHKEINNSNAQNPSAEEVGEEQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHETDEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQKQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDEAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYVVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELENVISLLFQNNEERGKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGINSDTNVRWNNCIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQHSNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETIENT", "length": 762, "header": "tr|E1BL80-1|E1BL80_BOVIN Isoform 1 of THAP domain containing 12 OS=Bos taurus OX=9913 GN=THAP12 PE=4 SV=2 CANONICAL=E1BL80-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZM6-1", "url": "https://www.uniprot.org/uniprotkb/E1BL80/entry#A0AAA9RZM6-1", "sequence": { "sequence": "MQPVVHTAAAAAAAKSLQSCLTLCDPIDGSPPGPAVPGILKARTLEWVAITFSGVDETSEQEPKHKEINNSNAQNPSAEEVGEEQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHETDEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQKQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDEAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYVVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELENVISLLFQNNEERGKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGINSDTNVRWNNCIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQHSNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETIENT", "length": 698, "header": "tr|A0AAA9RZM6-1|A0AAA9RZM6_BOVIN Computationally mapped isoform of THAP domain containing 12 OS=Bos taurus OX=9913 GN=THAP12 PE=4 SV=1 CANONICAL=E1BL80-1" }, "locus": { "chromosome": "15", "start_pos": 55765755, "end_pos": 55762485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124672.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124672.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078106.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078106.1" } ] } }, { "isoform_ac": "E1BL80-1", "url": "https://www.uniprot.org/uniprotkb/E1BL80/entry#E1BL80-1", "sequence": { "sequence": "MPNFCAAPNCTRKSTQSDLAFFRFPRDPTRCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEPKHKEINNSNAQNPSAEEVGEEQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHETDEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQKQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDEAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYVVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELENVISLLFQNNEERGKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGINSDTNVRWNNCIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQHSNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETIENT", "length": 762, "header": "tr|E1BL80-1|E1BL80_BOVIN Isoform 1 of THAP domain containing 12 OS=Bos taurus OX=9913 GN=THAP12 PE=4 SV=2 CANONICAL=E1BL80-1" }, "locus": { "chromosome": "15", "start_pos": 55791160, "end_pos": 55762485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044810.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044810.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042267.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042267.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508969", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508969", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K8V6-1", "protein_name": "THAP domain containing 12", "gene_name": "Thap12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIEETSEQEQETNSNAQNPSAEVGNQQDGNVLPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFAPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSEERGKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQQGNLESQLTSESYYKDALSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTNKSELPTNNSETIENT", "length": 757 }, "evidence": [ { "id": "E1BL80", "url": "https://omabrowser.org/oma/group/E1BL80/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0X560-1", "protein_name": "THAP domain containing 12", "gene_name": "THAP12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRQAPCGCLTAQARRPPALSLRREARRARQQPACAPLIWAPHGACTLRAAGLSALWEGGGPCSRRRVAVNPPGRSQQCGAASPPYPSSLPPPRPPPPPPPPPPHIPPLRPGGFKGAAPPIRGAMPNFCAAPNCTRKSTQSDLAFFRFPRDPVRCQRWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRSSPYRTVLRDNAVPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQQKINEAFEREQATQELNESNAQNAVSEEGGEQQEEKSVPLTLEERENKDYLKSLFEILILMGKQNIPLDSHNADELPEGIFTSDNFQALLEYRINAGDEVLRKRFEMTAVNLEYCSKTQQKQMLEICESCIREETLREVRDSHFFSIVTDEVVDIAGEEHLPVLVRFVDDSHNLREEFIGFLPYEADPEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFASKMKVVATRLLEKYPQAVYTLCSSCALNVWLAKSVPVVGVSMALGTIEEVRCLFSRSPQLLVELDNTISALFQNNEEKGNELKEICRSQWTGRHDTFEVLVDLMQALVLCLDAVSNDSTVRWNNFIAGRAFVLSSALTDFDFIVTIVILKNILSFTRAFGKNLQGQTSDIFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLAAKLDVQIKLPGKFRRSQQGNLDAELTSENYYKEILSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYKNDLPNPDTLSAELHCWRIKWKHRGKDIELPATIYEALHLPDIKYFPNVYALLKVLCILPVMKVENEKYEVGRKRLKAYLKNTVTEQRSSNLALLNINIDIKHDLDLMVDTYIKLYPVEENPSNRKLNDCRGGDKIQLPV", "length": 892 }, "evidence": [ { "id": "E1BL80", "url": "https://omabrowser.org/oma/group/E1BL80/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43422-1", "protein_name": "52 kDa repressor of the inhibitor of the protein kinase", "gene_name": "THAP12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETVENT", "length": 761 }, "evidence": [ { "id": "E1BL80", "url": "https://omabrowser.org/oma/group/E1BL80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CUX1-1", "protein_name": "52 kDa repressor of the inhibitor of the protein kinase", "gene_name": "Thap12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIEETSEQEQETNTNAQNPSAEAVNQQDANVLPLTLEEKENKEYLKSLFEILVLMGKQNIPLDGHEADEVPEGLFAPDNFQALLECRINSGEEVLRKRFEATAVNTLFCSKTQQRHMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFFHRSPQLLLELDSVISVLFQNSEERAKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGIINSDTNVRWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQQGNLESQLTSESYYKDTLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTNKSELPTINSETIENT", "length": 758 }, "evidence": [ { "id": "E1BL80", "url": "https://omabrowser.org/oma/group/E1BL80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BL80", "url": "https://www.uniprot.org/uniprotkb/E1BL80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL80-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 762, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL80-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL80" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL80" }, { "id": "PS50950", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50950" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THAP-type", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 86, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 619, "end_pos": 621 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL81-1", "uniprot_ac": "E1BL81", "uniprot_id": "E1BL81_BOVIN", "mass": { "chemical_mass": 34706.0, "monoisotopic_mass": 34706.0 }, "refseq": {}, "gene_names": [ { "name": "OR10D3", "type": "recommended", "evidence": [ { "id": "E1BL81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily D member 3", "type": "synonym", "evidence": [ { "id": "E1BL81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL81/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10D3", "url": "https://www.uniprot.org/uniprotkb/E1BL81", "locus": { "chromosome": "29", "start_pos": 26992324, "end_pos": 26991386, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016647", "url": "https://www.ensembl.org/id/ENSBTAG00000016647" } ] } } ], "crossref": [ { "id": "E1BL81", "url": "https://alphafold.ebi.ac.uk/entry/E1BL81", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15228", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15228", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL81-1", "url": "https://www.uniprot.org/uniprotkb/E1BL81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TEMKNCSEVTEFILLGIPHTEGLETLLFVLFLPFYACTLLGNMSILVTVLSSNSLHTPMYFFLGNLSVFDMSFSSVTCPKMLLYLMGLSPRISYKDCVSQLFFFHFLGSIDCFLYTVMAYDRFTAICHPLRYAVIMSPRVCVALAVGTWLLGCVHSSVLTLLTFTLPYCGPNEVAHFFCDIPALLPLACADTSLAQRVSFTNVGLVSLVCFLLILVSYTRIIISILRIPSAEGRHRAFSTCSAHLIAILCAYGHIITVYLQPTPNPMLGTVVQILMNLVGPMLNPLIYTLRNKEVKTALKKVLHRTNHVLVI", "length": 312, "header": "tr|E1BL81-1|E1BL81_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily D member 3 OS=Bos taurus OX=9913 GN=OR10D3 PE=3 SV=4 CANONICAL=E1BL81-1" }, "isoforms": [ { "isoform_ac": "E1BL81-1", "url": "https://www.uniprot.org/uniprotkb/E1BL81/entry#E1BL81-1", "sequence": { "sequence": "TEMKNCSEVTEFILLGIPHTEGLETLLFVLFLPFYACTLLGNMSILVTVLSSNSLHTPMYFFLGNLSVFDMSFSSVTCPKMLLYLMGLSPRISYKDCVSQLFFFHFLGSIDCFLYTVMAYDRFTAICHPLRYAVIMSPRVCVALAVGTWLLGCVHSSVLTLLTFTLPYCGPNEVAHFFCDIPALLPLACADTSLAQRVSFTNVGLVSLVCFLLILVSYTRIIISILRIPSAEGRHRAFSTCSAHLIAILCAYGHIITVYLQPTPNPMLGTVVQILMNLVGPMLNPLIYTLRNKEVKTALKKVLHRTNHVLVI", "length": 312, "header": "tr|E1BL81-1|E1BL81_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily D member 3 OS=Bos taurus OX=9913 GN=OR10D3 PE=3 SV=4 CANONICAL=E1BL81-1" }, "locus": { "chromosome": "29", "start_pos": 26992321, "end_pos": 26991386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030309.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030309.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030293.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030293.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BL81", "url": "https://www.uniprot.org/uniprotkb/E1BL81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL81-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL81-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL81" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL81" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BL93-1", "uniprot_ac": "E1BL93", "uniprot_id": "E1BL93_BOVIN", "mass": { "chemical_mass": 120750.0, "monoisotopic_mass": 120750.0 }, "refseq": { "ac": "XP_003587505", "name": "KAT8 regulatory NSL complex subunit 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587505" }, "gene_names": [ { "name": "KANSL1", "type": "recommended", "evidence": [ { "id": "E1BL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ] }, { "name": "KANSL1", "type": "synonym", "evidence": [ { "id": "XP_003587505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587505" } ] } ], "protein_names": [ { "name": "KAT8 regulatory NSL complex subunit 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003587505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587505" } ] }, { "name": "KAT8 regulatory NSL complex subunit 1", "type": "synonym", "evidence": [ { "id": "E1BL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL93/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KANSL1", "url": "https://www.uniprot.org/uniprotkb/E1BL93", "locus": { "chromosome": "19", "start_pos": 46009279, "end_pos": 46178316, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012564", "url": "https://www.ensembl.org/id/ENSBTAG00000012564" } ] } } ], "crossref": [ { "id": "E1BL93", "url": "https://alphafold.ebi.ac.uk/entry/E1BL93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012564", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012564", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535946", "url": "https://www.ncbi.nlm.nih.gov/gene/535946", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535946", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535946", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGGWSTP", "url": "https://omabrowser.org/oma/group/CGGWSTP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BL93", "url": "https://www.orthodb.org/?gene=E1BL93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZN9", "url": "https://www.orthodb.org/?gene=G3MZN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22443", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22443", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22443:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22443:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15275", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15275", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003587505", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587505", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL93-1", "url": "https://www.uniprot.org/uniprotkb/E1BL93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZN9", "url": "https://www.uniprot.org/uniprotkb/G3MZN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZN9-1", "url": "https://www.uniprot.org/uniprotkb/G3MZN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAMAPALTDAAAETHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLHGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSPLNGGKRALTSSSLQGGEVVASESGDLKGGMTNCTLPHRSLDVEHTTVFSNNSTANKSSVNSMEQPALQGSNRLSPDTDSSSNVGGVKLEGKKPPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETAASEGLSNFLKSDSISEELERFTASGIANLRCSERAFDSDITDSSSGGESDIEEEELARADPEQRHVPLRRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPPPEHTTTDLLLPLSSEVKTDHGNDKLIESVSQPLENHGASGHPSESLSAKSCGALRPVNGVINTLQPVLADHIPGDNSDAEEQLHKKQRLNLVASSTDGTCVAARTRPVLSCKKRRLVRPSSIVPLSKKVHRNSTVRSGCDVNPSCALCGSGSASTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTGLHFQSMLKSQWQNKPFDKIKPPKKFSLKHRAPMPGSLPDPTRKDRHKLVNSFLTTAKLSHHQARPDRTHRQHLDDVGAVPMVERVTAPKAERLLSPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSGSSYLAATHHPPHSPLVRQLSASSDTSAPTSSSPQVTASTTQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLRSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDTLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAESEDQLDAQERASRCTRRTSGSKTGRETEVAPTSPPVVPLKSRHLTATVTAQRPTHR", "length": 1103, "header": "tr|E1BL93-1|E1BL93_BOVIN Isoform 1 of KAT8 regulatory NSL complex subunit 1 OS=Bos taurus OX=9913 GN=KANSL1 PE=4 SV=2 CANONICAL=E1BL93-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHZ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BL93/entry#A0A3Q1MHZ0-1", "sequence": { "sequence": "MAAMAPALTDAAAETHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLHGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSPLNGGKRALTSSSLQGGEVVASESGDLKGGMTNCTLPHRSLDVEHTTVFSNNSTANKSSVNSMEQPALQGSNRLSPDTDSSSNVGGVKLEGKKPPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETAASEGLSNFLKSDSISEELERFTASGIANLRCSERAFDSDITDSSSGGESDIEEEELARADPEQRHVPLRRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKIESVSQPLENHGASGHPSESLSAKSCGALRPVNGVINTLQPVLADHIPGDNSDAEEQLHKKQRLNLVASSTDGTCVAARTRPVLSCKKRRLVRPSSIVPLSKKVHRNSTVRSGCDVNPSCALCGSGSASTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTGLHFQSMLKSQWQNKPFDKIKPPKKFSLKHRAPMPGSLPDPTRKDRHKLVNSFLTTAKLSHHQARPDRTHRQHLDDVGAVPMVERVTAPKAERLLSPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSGSSYLAATHHPPHSPLVRQLSASSDTSAPTSSSPQVTASTTQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLRSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDTLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAESEDQLDAQERASRCTRRTSGSKTGRETEVAPTSPPVVPLKSRHLTATVTAQRPTHR", "length": 1068, "header": "tr|A0A3Q1MHZ0-1|A0A3Q1MHZ0_BOVIN Computationally mapped isoform of KAT8 regulatory NSL complex subunit 1 OS=Bos taurus OX=9913 GN=KANSL1 PE=4 SV=1 CANONICAL=E1BL93-1" }, "locus": { "chromosome": "19", "start_pos": 46135794, "end_pos": 46010283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074972.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074972.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070317.1" } ] } }, { "isoform_ac": "E1BL93-1", "url": "https://www.uniprot.org/uniprotkb/E1BL93/entry#E1BL93-1", "sequence": { "sequence": "MAAMAPALTDAAAETHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLHGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSPLNGGKRALTSSSLQGGEVVASESGDLKGGMTNCTLPHRSLDVEHTTVFSNNSTANKSSVNSMEQPALQGSNRLSPDTDSSSNVGGVKLEGKKPPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETAASEGLSNFLKSDSISEELERFTASGIANLRCSERAFDSDITDSSSGGESDIEEEELARADPEQRHVPLRRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPPPEHTTTDLLLPLSSEVKTDHGNDKLIESVSQPLENHGASGHPSESLSAKSCGALRPVNGVINTLQPVLADHIPGDNSDAEEQLHKKQRLNLVASSTDGTCVAARTRPVLSCKKRRLVRPSSIVPLSKKVHRNSTVRSGCDVNPSCALCGSGSASTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTGLHFQSMLKSQWQNKPFDKIKPPKKFSLKHRAPMPGSLPDPTRKDRHKLVNSFLTTAKLSHHQARPDRTHRQHLDDVGAVPMVERVTAPKAERLLSPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSGSSYLAATHHPPHSPLVRQLSASSDTSAPTSSSPQVTASTTQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLRSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDTLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAESEDQLDAQERASRCTRRTSGSKTGRETEVAPTSPPVVPLKSRHLTATVTAQRPTHR", "length": 1103, "header": "tr|E1BL93-1|E1BL93_BOVIN Isoform 1 of KAT8 regulatory NSL complex subunit 1 OS=Bos taurus OX=9913 GN=KANSL1 PE=4 SV=2 CANONICAL=E1BL93-1" }, "locus": { "chromosome": "19", "start_pos": 46135794, "end_pos": 46010283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034753.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034753.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034638.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034638.4" } ] } }, { "isoform_ac": "G3MZN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BL93/entry#G3MZN9-1", "sequence": { "sequence": "MAAMAPALTDAAAETHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLHGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSPLNGGKRALTSSSLQGGEVVASESGDLKGGMTNCTLPHRSLDVEHTTVFSNNSTANKSSVNSMEQPALQGSNRLSPDTDSSSNVGGVKLEGKKPPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETAASEGLSNFLKSDSISEELERFTASGIANLRCSERAFDSDITDSSSGGESDIEEEELARADPEQRHVPLRRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPPPEHTTTDLLLPLSSEVKTDHGNDKLIESVSQPLENHGASGHPSESLSAKSCGALRPVNGVINTLQPVLADHIPGDNSDAEEQLHKKQRLNLVASSTDGTCVAARTRPVLSCKKRRLVRPSSIVPLSKKVHRNSTVRSGCDVNPSCALCGSGSASTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTGLHFQSMLKSQWQNKPFDKIKPPKKFSLKHRAPMPGSLPDPTRKDRHKLVNSFLTTAMLKHHTDMSGSSYLAATHHPPHSPLVRQLSASSDTSAPTSSSPQVTASTTQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLRSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDTLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAESEDQLDAQERASRCTRRTSGSKTGRETEVAPTSPPVVPLKSRHLTATVTAQRPTHR", "length": 1040, "header": "tr|G3MZN9-1|G3MZN9_BOVIN Computationally mapped isoform of KAT8 regulatory NSL complex subunit 1 OS=Bos taurus OX=9913 GN=KANSL1 PE=4 SV=1 CANONICAL=E1BL93-1" }, "locus": { "chromosome": "19", "start_pos": 46135794, "end_pos": 46010283, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066075.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066075.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000055041.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1079, "start_aa": "Thr", "end_pos": 1079, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1079", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535946", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535946", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214847", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "resource": "Reactome", "description": "HATs acetylate histones" }, { "id": "R-BTA-9772755", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "resource": "Reactome", "description": "Formation of WDR5-containing histone-modifying complexes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UI25-1", "protein_name": "KAT8 regulatory NSL complex subunit 1", "gene_name": "KANSL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAESNGNANDILLAANGTKRKAIAPEDPSLDFRNNPTKEELGKLQPLVASYLCSDVTSVSSKEPLKLQGVFNKQTVLKSHSLLSQSFLKTSDLLGRQPVLEFTLENLKTMSANSQPPLPQAPVNGLAKKLAKSTNSDHENSSALNGGKCASPAAALQGADCNAGGSELGDLKAGLTNCTLPHRSLDAERATPFSNNSTANKSSLNSTEQQQQQQQVLEGGSGETRLPGVGAHSDLGGSKLEEQKPSLPAGHHSALDSEMRTRALLRRQADIESRARRLQKRLQVVQAKQVERHIQQQLGGFLEKTLSKLPTLDPVRHRSQLMLTRKAEAALRKAASETVTSEGLSSFLKSDSISEELERFTASGMANLRSSEQAFDSDVTDSSSGGESDVEEEELTKADPEQPHVPLRRRAEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEASPPDPAADDASRPMSADVKLEPGAERLSVSGSQPLDSLGLSAASTPESHPTKPCGAPRPVNGVINTLQPGLAEHAQGDGQEAEELLHKKQRLNAVPSASDGTCVAARTRPVLSCKKRRLVRPSSIMPLSKKVHRNSLARCSCDVNPSCALCGARSSAALDMQYDAPLLERLSQLDSCIHPVLSFPDDVPTSLHFQSMLKSQWQNKPYEKMKAPKKLSLKHRAPMPTSSLTDPARKDRHKLVNSFFTAAKRSQHKPQADKAHRPPLDDFMAVSKAERAPERSLAQPPAHDKKRLRDCSSERSEVLKHHADVGGPSYLAAAATHAPHSPIARQLSASSEGSAPTSTSSQGTSSTAQPRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDIGALKVSPDEDNEEIEDLSDSAFAARHSKCEEMERARWLWSTSVPPQRRGSRSYRSTDGRTTPQLGTPSTPQPASPDVGSCHSHSEPSHTHSPRSPISPELLSAPLTPLCRDSLRLLPSEDTRCSTPEAPDEQAVLPWERRCFPLSYDPRTECEDQCDPQDRSSRCTRRTSGSKSSRDTDGTSASPTLSGIKSRPPPATPPPSSSSSSSSSAAAAVQRPAHR", "length": 1114 }, "evidence": [ { "id": "E1BL93", "url": "https://omabrowser.org/oma/group/E1BL93/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6AJF7-1", "protein_name": "KAT8 regulatory NSL complex subunit 1", "gene_name": "Kansl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILISANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGGKRSLTSSSLQGGEVGGSDSGNLKGGMTNCTLPHRSLDTQHTTLYSNNSTVNKSPVNSMEQPALQGSSRLSPSTDSCSNLTSVKLEVKKSPLSSILFSALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHLQHQLGGFLEKTLSKLPNLESLRSRSQLMLTRKAEAALRKAASETATSEGLSNFLKSDSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEASFPDHTTDLLSLSSEVKTDHGSDKLIESVSQPSENHGIPVSHITESLSTKTCGALRPVNGVVNSLQPVLADQVPGDSSDAEEQIHKKQRLNLVSSSSDGTCVAARTRPVLSCKKRRLVRPSSIVPLSKKVHRNIRSGCDVNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPTKKFSLKHRAPMPCSLSDPVRKDRHKLVNSFLTTSKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLHLPPPVHDPTHSKLRLRDHSSERSEVLKHHTDMSSSSYLTATHHSPHSPLVRQLSTSSDTSTPTSSSSQVAASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDSLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAECDEQLDAQDTAARCTRRTSGSKTGRETEVAPTSPPVVPLKSRHLAATVAAQRPTHR", "length": 1100 }, "evidence": [ { "id": "E1BL93", "url": "https://omabrowser.org/oma/group/E1BL93/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z3B3-1", "protein_name": "KAT8 regulatory NSL complex subunit 1", "gene_name": "KANSL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGKRALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGAPIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR", "length": 1105 }, "evidence": [ { "id": "E1BL93", "url": "https://omabrowser.org/oma/group/E1BL93/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80TG1-1", "protein_name": "KAT8 regulatory NSL complex subunit 1", "gene_name": "Kansl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILISANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPAKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGGKRSLTSSSLQGGEVGGPDSGNLKGGMTNCTLPHRSLDIQHTTLYSNNSTANKSSVNSMDQPALQGSSRLSPSTDSSSNLTNVKLEVKKSPLSSILFSALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHLQHQLGGFLETTLSKLPNLESLRSRSQLMLTRKAEAALRKAASESATSEGLSNFLKSDSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPFPDHTTDLLSLSSEVKTDHGRDKLIESVSQPSENHGILVSNITESLSTKSCGAPRPVNGVVNSLQPVLADQVPGDSSDAEEQLHKKQRLNLVSSSDGTCVAARTRPVLTCKKRRLVRPSSIVPLSKKVHRNVRSGCDVNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPTKKFSLKHRATMPCSLSDPVRKDRHKLVNSFLTTAMLKHHTDMSSPSYLTATHHPPHSPLVRQLSTSSDTSTPTSSGSQVAASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDVQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDSLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAECEEQLDAQDTAARCTRRTSGSKTGREAEVAPTSPPVVPLKSRHLAATVTAQRPAHR", "length": 1036 }, "evidence": [ { "id": "E1BL93", "url": "https://omabrowser.org/oma/group/E1BL93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" }, { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" }, { "name": "NSL complex", "id": "GO:0044545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044545", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" }, { "name": "H4 histone acetyltransferase complex", "id": "GO:1902562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902562", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histone acetyltransferase binding", "id": "GO:0035035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035035", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of mitochondrial transcription", "id": "GO:1903108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903108", "evidence": [ { "database": "UniProtKB", "id": "E1BL93", "url": "https://www.uniprot.org/uniprotkb/E1BL93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 781, "end_pos": 783, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BL93-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1103, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BL93-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BL93" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BL93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL93" }, { "id": "PS52052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PEHE", "eco_id": "ECO_0000259", "start_pos": 882, "end_pos": 1033, "start_aa": "Glu", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1079 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 230, "end_pos": 232 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 619, "end_pos": 621 }, { "start_pos": 781, "end_pos": 783 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLA2-1", "uniprot_ac": "E1BLA2", "uniprot_id": "E1BLA2_BOVIN", "mass": { "chemical_mass": 86433.0, "monoisotopic_mass": 86433.0 }, "refseq": {}, "gene_names": [ { "name": "TSNAXIP1", "type": "recommended", "evidence": [ { "id": "E1BLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA2" } ] } ], "protein_names": [ { "name": "Translin associated factor X interacting protein 1", "type": "synonym", "evidence": [ { "id": "E1BLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLA2", "url": "https://www.uniprot.org/uniprotkb/E1BLA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSNAXIP1", "url": "https://www.uniprot.org/uniprotkb/E1BLA2", "locus": { "chromosome": "18", "start_pos": 35338631, "end_pos": 35327597, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006387", "url": "https://www.ensembl.org/id/ENSBTAG00000006387" } ] } } ], "crossref": [ { "id": "E1BLA2", "url": "https://alphafold.ebi.ac.uk/entry/E1BLA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006387", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006387", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR032755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BLA2", "url": "https://www.orthodb.org/?gene=E1BLA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16306:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16306:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BLA2", "url": "https://www.uniprot.org/uniprotkb/E1BLA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCWDLVAMVTDCTLPELPRPRVRAARLPGCPRVMDSPNSQPLNFPTTSRAHLRPLGVSIDDSLFTETKNTQKRKLSQKRKTLLSGSFSIGGHLSPWPRYISDQTILHNRKPCSDDYRKRAGSLQQPLGTTKPRYLEQLENYLRKELLLLDLSTDSAQELRLQPYREIFEFFIEDFKTYKPLLSSIKHQREKIRALEPLKAKLITVNENCNERILAMRAEERDEISMLKKEKMNLLKLIDKKNEEKISLQTEVTKLRKNLAEEYLHYLSERDARKILIADLNELRYQREDMSLAQSPGVWGEDPVKLTVALKMARQDLTRTQMELNTMKANFGDVVPRRDFEMQEKTLKELQEQLESLRDDYEEVRKEHEMLLQLHMSTLKERDQFYSELQEIQRTSTPRPDWSKCEDMVAGGRDRWHMLAEGKNSDQLVDVLLEEIGEGLLREKDFFPGLGYGESIPPFLRFDGIVENKKPTKKEVVKLLKDAWKERITEEQKEKFPDFFFSFLERHFGPGDAMAWAYTIFEYIKLFHTNEVMSQFYAVLMGKRKESVYIKQKQTIAQLLKEMTNVDSQNEGLLTMEQLSTVLKSTFPLKKDERIQELMEAGGWHPSSSNADLLDYRLLFMEDEEGQSVPFVQKLWEQYVVEKDEYLNELKQELGLELNEEVTLPKVREALMNIDPNLDKQTLNHYLRQAFQLPMTEMPEEDEEREEGIVTQLQTALEQLQMSDIRRMGPREQEPAS", "length": 738, "header": "tr|E1BLA2-1|E1BLA2_BOVIN Isoform 1 of Translin associated factor X interacting protein 1 OS=Bos taurus OX=9913 GN=TSNAXIP1 PE=4 SV=4 CANONICAL=E1BLA2-1" }, "isoforms": [ { "isoform_ac": "E1BLA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA2/entry#E1BLA2-1", "sequence": { "sequence": "MGCWDLVAMVTDCTLPELPRPRVRAARLPGCPRVMDSPNSQPLNFPTTSRAHLRPLGVSIDDSLFTETKNTQKRKLSQKRKTLLSGSFSIGGHLSPWPRYISDQTILHNRKPCSDDYRKRAGSLQQPLGTTKPRYLEQLENYLRKELLLLDLSTDSAQELRLQPYREIFEFFIEDFKTYKPLLSSIKHQREKIRALEPLKAKLITVNENCNERILAMRAEERDEISMLKKEKMNLLKLIDKKNEEKISLQTEVTKLRKNLAEEYLHYLSERDARKILIADLNELRYQREDMSLAQSPGVWGEDPVKLTVALKMARQDLTRTQMELNTMKANFGDVVPRRDFEMQEKTLKELQEQLESLRDDYEEVRKEHEMLLQLHMSTLKERDQFYSELQEIQRTSTPRPDWSKCEDMVAGGRDRWHMLAEGKNSDQLVDVLLEEIGEGLLREKDFFPGLGYGESIPPFLRFDGIVENKKPTKKEVVKLLKDAWKERITEEQKEKFPDFFFSFLERHFGPGDAMAWAYTIFEYIKLFHTNEVMSQFYAVLMGKRKESVYIKQKQTIAQLLKEMTNVDSQNEGLLTMEQLSTVLKSTFPLKKDERIQELMEAGGWHPSSSNADLLDYRLLFMEDEEGQSVPFVQKLWEQYVVEKDEYLNELKQELGLELNEEVTLPKVREALMNIDPNLDKQTLNHYLRQAFQLPMTEMPEEDEEREEGIVTQLQTALEQLQMSDIRRMGPREQEPAS", "length": 738, "header": "tr|E1BLA2-1|E1BLA2_BOVIN Isoform 1 of Translin associated factor X interacting protein 1 OS=Bos taurus OX=9913 GN=TSNAXIP1 PE=4 SV=4 CANONICAL=E1BLA2-1" }, "locus": { "chromosome": "18", "start_pos": 35338467, "end_pos": 35327705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008380.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008380.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008380.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008380.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BLA2", "url": "https://www.uniprot.org/uniprotkb/E1BLA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 738, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLA2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA2" }, { "id": "PF15739", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15739" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Translin-associated factor X-interacting protein 1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 140, "end_pos": 241, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLA5-1", "uniprot_ac": "E1BLA5", "uniprot_id": "E1BLA5_BOVIN", "mass": { "chemical_mass": 97450.0, "monoisotopic_mass": 97450.0 }, "refseq": {}, "gene_names": [ { "name": "ARHGEF33", "type": "recommended", "evidence": [ { "id": "E1BLA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA5" } ] } ], "protein_names": [ { "name": "Rho guanine nucleotide exchange factor 33", "type": "synonym", "evidence": [ { "id": "E1BLA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLA5", "url": "https://www.uniprot.org/uniprotkb/E1BLA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGEF33", "url": "https://www.uniprot.org/uniprotkb/E1BLA5", "locus": { "chromosome": "11", "start_pos": 21339239, "end_pos": 21243882, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017039", "url": "https://www.ensembl.org/id/ENSBTAG00000017039" } ] } } ], "crossref": [ { "id": "E1BLA5", "url": "https://alphafold.ebi.ac.uk/entry/E1BLA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017039", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017039", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46944:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46944:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MIT6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIT6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLA5", "url": "https://www.uniprot.org/uniprotkb/E1BLA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKTKTKQGDNEHKPMNNPSAQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHGSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQETRSMHVGDSNVKGMMGPGMTPTTSEAEENLKPCLSADIQPKSHLPPGVWRQPKEAKDWGEEYVTKDHPDKLKEVSQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYIVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDSGIHSEEMLQPYPSAPSSGPAVTHLMPPVKKSQQQQSLMESMQPGKPSDWEMEGRKHERPESLLAPAQFCAAEQDVKALAGPLQAIPEMDFEPSPAEPLGNVERSLRAPAELLPDARSYVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHKTKPLSRSLKEFPRAPPPEGVAPRLYSTRSSSGGRAPLKAERAAQAHGPAASARGAPRTFFPQQRSQSEKQTYLEVRREMHLEDATRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKSSGSEYREKTNENPSMDPSPTKQDFFRNRLALANELDQGTAV", "length": 866, "header": "tr|E1BLA5-1|E1BLA5_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 33 OS=Bos taurus OX=9913 GN=ARHGEF33 PE=4 SV=4 CANONICAL=E1BLA5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA5/entry#A0A3Q1MIT6-1", "sequence": { "sequence": "MEKTKTKQGDNEHKPMNNPSAQIYQASKYKSSLNLPPVGARLQRQDGGIITSLEQLHEKINEMRNVFNSLENKLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHGSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQETRSMHVGDSNVKGMMGPGMTPTTSEAEENLKPCLSADIQPKSHLPPGVWRQPKEAKDWGEEYVTKDHPDKLKEVSQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYIVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDSGIHSEEMLQPYPSAPSSGPAVTHLMPPVKKSQQQQSLMESMQPGKPSDWEMEGRKHERPESLLAPAQFCAAEQDVKALAGPLQAIPEMDFEPSPAEPLGNVERSLRAPAELLPDARSYVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHKTKPLSRSLKEFPRAPPPEGVAPRLYSTRSSSGGRAPLKAERAAQAHGPAASARGAPRTFFPQQRSQSEKQTYLEVRREMHLEDATRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKSSGSEYREKTNENPSMDPSPTKQDFFRNRLALANELDQGTAV", "length": 914, "header": "tr|A0A3Q1MIT6-1|A0A3Q1MIT6_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 33 OS=Bos taurus OX=9913 GN=ARHGEF33 PE=4 SV=2 CANONICAL=E1BLA5-1" }, "locus": { "chromosome": "11", "start_pos": 21295042, "end_pos": 21243882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069090.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069090.2" } ] } }, { "isoform_ac": "A0AAA9S9N6-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA5/entry#A0AAA9S9N6-1", "sequence": { "sequence": "MHLEDATRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNSTGEDFCGPWGWW", "length": 62, "header": "tr|A0AAA9S9N6-1|A0AAA9S9N6_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 33 OS=Bos taurus OX=9913 GN=ARHGEF33 PE=4 SV=2 CANONICAL=E1BLA5-1" }, "locus": { "chromosome": "11", "start_pos": 21293107, "end_pos": 21287956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080122.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080122.2" } ] } }, { "isoform_ac": "E1BLA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA5/entry#E1BLA5-1", "sequence": { "sequence": "MEKTKTKQGDNEHKPMNNPSAQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHGSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQETRSMHVGDSNVKGMMGPGMTPTTSEAEENLKPCLSADIQPKSHLPPGVWRQPKEAKDWGEEYVTKDHPDKLKEVSQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYIVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDSGIHSEEMLQPYPSAPSSGPAVTHLMPPVKKSQQQQSLMESMQPGKPSDWEMEGRKHERPESLLAPAQFCAAEQDVKALAGPLQAIPEMDFEPSPAEPLGNVERSLRAPAELLPDARSYVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHKTKPLSRSLKEFPRAPPPEGVAPRLYSTRSSSGGRAPLKAERAAQAHGPAASARGAPRTFFPQQRSQSEKQTYLEVRREMHLEDATRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKSSGSEYREKTNENPSMDPSPTKQDFFRNRLALANELDQGTAV", "length": 866, "header": "tr|E1BLA5-1|E1BLA5_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 33 OS=Bos taurus OX=9913 GN=ARHGEF33 PE=4 SV=4 CANONICAL=E1BLA5-1" }, "locus": { "chromosome": "11", "start_pos": 21295042, "end_pos": 21243882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022655.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022655.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022655.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022655.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1BLA5", "url": "https://www.uniprot.org/uniprotkb/E1BLA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 866, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLA5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BLA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA5" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 265, "end_pos": 440, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 642, "end_pos": 644 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLA8-1", "uniprot_ac": "E1BLA8", "uniprot_id": "E1BLA8_BOVIN", "mass": { "chemical_mass": 45536.0, "monoisotopic_mass": 45536.0 }, "refseq": { "ac": "NP_001179392", "name": "Golgi membrane protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179392" }, "gene_names": [ { "name": "GOLM1", "type": "recommended", "evidence": [ { "id": "E1BLA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA8" } ] }, { "name": "GOLM1", "type": "synonym", "evidence": [ { "id": "NP_001179392", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179392" } ] } ], "protein_names": [ { "name": "Golgi membrane protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179392", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179392" }, { "id": "E1BLA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLA8", "url": "https://www.uniprot.org/uniprotkb/E1BLA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLM1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8", "locus": { "chromosome": "8", "start_pos": 79262658, "end_pos": 79321512, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031569", "url": "https://www.ensembl.org/id/ENSBTAG00000031569" } ] } } ], "crossref": [ { "id": "E1BLA8", "url": "https://alphafold.ebi.ac.uk/entry/E1BLA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031569", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031569", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517052", "url": "https://www.ncbi.nlm.nih.gov/gene/517052", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517052", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517052", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DVYWFQK", "url": "https://omabrowser.org/oma/group/DVYWFQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BLA8", "url": "https://www.orthodb.org/?gene=E1BLA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15896", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15896", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15896:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15896:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179392", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RSD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6K6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6K6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLA8", "url": "https://www.uniprot.org/uniprotkb/E1BLA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALQKSYGRLQQDVLQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTRKGNEAMPSHDLNEQKDQSQQPRAPSESQPRPQEAGPPQAEVPEARGNVPSHSEPQTPAPSSEVAFDLKRQGEKEETKEIQVVSEEELQRDSLALPKEPGREQEVEGDRQVGGKGNGEPGELGQIPQVPAALLASQENQEAEGPERDQLVIRDGQEEGQDADEEGRNQQKLGADDDYNMDENEAESETDKQAALAGNDKNRNVLNAENQKGDTINLLDQHEKRNHTL", "length": 405, "header": "tr|E1BLA8-1|E1BLA8_BOVIN Isoform 1 of Golgi membrane protein 1 OS=Bos taurus OX=9913 GN=GOLM1 PE=3 SV=1 CANONICAL=E1BLA8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8/entry#A0AAA9RSD5-1", "sequence": { "sequence": "MGAVGSGFRKIPPGRRWGTLRGGEEGGLPGPFFPSPLLTSFKSIETALLVCRSPGPKARREPRVLSPALEMMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALQKSYGRLQQDVLQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTRKGNEAMPSHDLNEQKDQSQQPRAPSESQPRPQEAGPPQAEVPEARGNVPSHSEPQTPAPSSEVAFDLKRQGEKEETKEIQVVSEEELQRDSLALPKEPGREQEVEGDRQVGGKGNGEPGELGQIPQVPAALLASQENQEAEGPERDQLVIRDGQEEGQDADEEGRNQQKLGADDDYNMDENEAESETDKQAALAGNDKNRNGIS", "length": 453, "header": "tr|A0AAA9RSD5-1|A0AAA9RSD5_BOVIN Computationally mapped isoform of Golgi membrane protein 1 OS=Bos taurus OX=9913 GN=GOLM1 PE=3 SV=1 CANONICAL=E1BLA8-1" }, "locus": { "chromosome": "8", "start_pos": 79321501, "end_pos": 79263662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075449.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075449.1" } ] } }, { "isoform_ac": "A0AAA9SKW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8/entry#A0AAA9SKW7-1", "sequence": { "sequence": "MGAVGSGFRKIPPGRRWGTLRGGEEGGLPGPFFPSPLLTSFKSIETALLVCRSPGPKARREPRVLSPALEMMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALQKSYGRLQQDVLQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTRKGNEAMPSHDLNEQKDQSQQPRAPSESQPRPQEAGPPQAEVPEARGNVPSHSEPQTPAPSSEVAFDLKRQGEKEETKEIQVVSEEELQRDSLALPKEPGREQEVEGDRQVGGKGNGEPGELGQIPQVPAALLASQENQEAEGPERDQLVIRDGQEEGQDADEEGRNQQKLGADDDYNMDENEAESETDKQAALAGNDKNRNVLNAENQKGDTINLLDQHEKRNHTL", "length": 475, "header": "tr|A0AAA9SKW7-1|A0AAA9SKW7_BOVIN Computationally mapped isoform of Golgi membrane protein 1 OS=Bos taurus OX=9913 GN=GOLM1 PE=3 SV=1 CANONICAL=E1BLA8-1" }, "locus": { "chromosome": "8", "start_pos": 79321501, "end_pos": 79263911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084552.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084552.1" } ] } }, { "isoform_ac": "A0ABI0P6K6-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8/entry#A0ABI0P6K6-1", "sequence": { "sequence": "MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALQKSYGRLQQDVLQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTRKGNEAMPSHDLNEQKDQSQQPRAPSESQPRPQEAGPPQAEVPEARGNVPSHSEPQTPAPSSEVAFDLKRQGEKEETKEIQVVSEEELQRDSLALPKEPGREQEVEGDRQVGGKGNGEPGELGQIPQVPAALLASQENQEAEGPERDQLVIRDGQEEGQDADEEGRNQQKLGADDDYNMDENEAESETDKQAALAGNDKNRNGVRLRI", "length": 386, "header": "tr|A0ABI0P6K6-1|A0ABI0P6K6_BOVIN Computationally mapped isoform of Golgi membrane protein 1 OS=Bos taurus OX=9913 GN=GOLM1 PE=3 SV=1 CANONICAL=E1BLA8-1" }, "locus": { "chromosome": "8", "start_pos": 79310527, "end_pos": 79264780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107446.1" } ] } }, { "isoform_ac": "E1BLA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BLA8/entry#E1BLA8-1", "sequence": { "sequence": "MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALQKSYGRLQQDVLQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTRKGNEAMPSHDLNEQKDQSQQPRAPSESQPRPQEAGPPQAEVPEARGNVPSHSEPQTPAPSSEVAFDLKRQGEKEETKEIQVVSEEELQRDSLALPKEPGREQEVEGDRQVGGKGNGEPGELGQIPQVPAALLASQENQEAEGPERDQLVIRDGQEEGQDADEEGRNQQKLGADDDYNMDENEAESETDKQAALAGNDKNRNVLNAENQKGDTINLLDQHEKRNHTL", "length": 405, "header": "tr|E1BLA8-1|E1BLA8_BOVIN Isoform 1 of Golgi membrane protein 1 OS=Bos taurus OX=9913 GN=GOLM1 PE=3 SV=1 CANONICAL=E1BLA8-1" }, "locus": { "chromosome": "8", "start_pos": 79310527, "end_pos": 79263911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044756.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044756.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042222.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042222.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517052", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517052", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S4I1-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVEMKKNEFQGELEKQREQLDKIQSSHNFQMESVNKLYQDEKAVLVNNITTGERLIRTLQDQLKALEKNYGRLQQDVFQFQKNQTNLERKFSYDLNQCISQMKEVKEQCEERIEEVTKKGNEAAASRDLSEQKDPSQQLPAPNQPQPRPQEADLPQAGVSQARGRAPGNGEPRTPAPSAEAVLDLKRQGEKEETKEIQVASEEEEAAAAQRDALGQPQDPGQEQAGAEARDVGGEPGEVGRTPQAPAAPLASQEDQDLEGPERDQLVIVDRKEEGQEADEEGRDPQKLGTDEDYNVDENEAESERDKQAALAGNDRNGNVLDAEHQKGDMINLLDQRPKRNHTL", "length": 405 }, "evidence": [ { "id": "E1BLA8", "url": "https://omabrowser.org/oma/group/E1BLA8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NBJ4-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIMELEGRVRRAAAERGAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDEKAVLVNNITTGERLIRVLQDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEERIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVNEEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYNMDENEAESETDKQAALAGNDRNIDVFNVEDQKRDTINLLDQREKRNHTL", "length": 401 }, "evidence": [ { "id": "E1BLA8", "url": "https://omabrowser.org/oma/group/E1BLA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91XA2-1", "protein_name": "Golgi membrane protein 1", "gene_name": "Golm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMGLGNGRRSMKSPPLILAALVACVIVLGFNYWIASSRSVELQTRIVELEGRVRRAAAERGAVELKKNEFQGELQKQREQLDRIQSSHSFQLENVNKLHQDEKAVLVNNITTGEKLIRDLQDQLKALQRSYSSLQQDIFQFQKNQTSLEKKFSYDLNQCISQMTEVKEQCDERIEEVIRKRNEAPGSRDLAETNNQHQQALKPQPKLQEEVPSEEQMPQEKGDVPRNKSQIPAPNSESLGLKPQVQNEETNEIQAVGEEHQQASIQGQAVADGTRVGAEKLDQHTQLPAGLLARPEEDSQYPEREQLVIRDRQEQQRASEEGGGQKNPGDEYDMDENEAESEREKQAALAGNDRNINVLNADAQKRGIINVPVGSERQSHILNQVGIHIPQQA", "length": 393 }, "evidence": [ { "id": "E1BLA8", "url": "https://omabrowser.org/oma/group/E1BLA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BLA8", "url": "https://www.uniprot.org/uniprotkb/E1BLA8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BLA8", "url": "https://www.uniprot.org/uniprotkb/E1BLA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 405, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLA8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 144, "end_pos": 146 }, { "start_pos": 402, "end_pos": 404 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLD3-1", "uniprot_ac": "E1BLD3", "uniprot_id": "E1BLD3_BOVIN", "mass": { "chemical_mass": 16593.0, "monoisotopic_mass": 16593.0 }, "refseq": {}, "gene_names": [ { "name": "LCN8", "type": "recommended", "evidence": [ { "id": "E1BLD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD3" } ] } ], "protein_names": [ { "name": "Lipocalin 8", "type": "synonym", "evidence": [ { "id": "E1BLD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLD3", "url": "https://www.uniprot.org/uniprotkb/E1BLD3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LCN8", "url": "https://www.uniprot.org/uniprotkb/E1BLD3", "locus": { "chromosome": "11", "start_pos": 105881992, "end_pos": 105878886, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017005", "url": "https://www.ensembl.org/id/ENSBTAG00000017005" } ] } } ], "crossref": [ { "id": "E1BLD3", "url": "https://alphafold.ebi.ac.uk/entry/E1BLD3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017005", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017005", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BLD3", "url": "https://www.uniprot.org/uniprotkb/E1BLD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLD3-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGFWWEAGVASRENLALKTPRRLEALFLTLSGETLTVAVAYNNSGSCQTEEIVSSEMNVWGKFVFPGRREIHVVDTDYEQYAILRVSLQWQNHEFYVFKYFTRSLGGECEPGFLKFRELTTDMGLYLVGRHGRCAMLLKEHLT", "length": 144, "header": "tr|E1BLD3-1|E1BLD3_BOVIN Isoform 1 of Lipocalin 8 OS=Bos taurus OX=9913 GN=LCN8 PE=3 SV=5 CANONICAL=E1BLD3-1" }, "isoforms": [ { "isoform_ac": "E1BLD3-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD3/entry#E1BLD3-1", "sequence": { "sequence": "MVGFWWEAGVASRENLALKTPRRLEALFLTLSGETLTVAVAYNNSGSCQTEEIVSSEMNVWGKFVFPGRREIHVVDTDYEQYAILRVSLQWQNHEFYVFKYFTRSLGGECEPGFLKFRELTTDMGLYLVGRHGRCAMLLKEHLT", "length": 144, "header": "tr|E1BLD3-1|E1BLD3_BOVIN Isoform 1 of Lipocalin 8 OS=Bos taurus OX=9913 GN=LCN8 PE=3 SV=5 CANONICAL=E1BLD3-1" }, "locus": { "chromosome": "11", "start_pos": 105881890, "end_pos": 105880210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022613.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022613.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022613.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022613.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "E1BLD3", "url": "https://www.uniprot.org/uniprotkb/E1BLD3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLD3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLD3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLD3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BLD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD3" }, { "id": "PF00061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipocalin/cytosolic fatty-acid binding", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 105, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLD4-1", "uniprot_ac": "E1BLD4", "uniprot_id": "E1BLD4_BOVIN", "mass": { "chemical_mass": 85196.0, "monoisotopic_mass": 85196.0 }, "refseq": {}, "gene_names": [ { "name": "RBM28", "type": "recommended", "evidence": [ { "id": "E1BLD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ] } ], "protein_names": [ { "name": "RNA-binding protein 28", "type": "recommended", "evidence": [ { "id": "E1BLD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD4/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 28", "type": "synonym", "evidence": [ { "id": "E1BLD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Nucleolar component of the spliceosomal ribonucleoprotein complexes.", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4#function" }, { "database": "UniProtKB", "id": "ARBA00053567", "url": "https://www.uniprot.org/uniprotkb/ARBA00053567#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM28", "url": "https://www.uniprot.org/uniprotkb/E1BLD4", "locus": { "chromosome": "4", "start_pos": 92500531, "end_pos": 92531702, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017001", "url": "https://www.ensembl.org/id/ENSBTAG00000017001" } ] } } ], "crossref": [ { "id": "E1BLD4", "url": "https://alphafold.ebi.ac.uk/entry/E1BLD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017001", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017001", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12413", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12413", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12414", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12414", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12415", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12415", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BLD4", "url": "https://www.orthodb.org/?gene=E1BLD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZL2", "url": "https://www.orthodb.org/?gene=G3MZL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48039", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48039", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48039:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48039:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLD4-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZL2", "url": "https://www.uniprot.org/uniprotkb/G3MZL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZL2-1", "url": "https://www.uniprot.org/uniprotkb/G3MZL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMVEDVQRALKEITTFEGCKINVTIAKKKLRNKSKEKGKTENSESPEKELKPKKAKVADKKARLIIRNLSFKCSEDDLKTVFSQFGTILEVNIPRKPDGKMRGFAFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKSTQSASIPGEEKRPEPEHQELDQENGREEEDMEEGENESDYDDDEEEEEDKESKLPKSVQIHKRAVKRPAPAESSDEEHSDDDSDLEERDSIDGGEDLAQSDTSSEEQEEEDIEVSKKKRKKRKLPSDVNEGKTVFIRNLSFDSEEEDLGELLQQFGDLKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLEAASPEAEGGGLKLDGRQLKVDLAVTRDEAAKLRTKKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLNSTRGEKAVRIKECRVMRDLKGAYGKIKGQSLGYAFAEFQEHEHALAALRHINNNPEIFGPQKRPIVEFSLEDRRKLKVKELRIQRSQQKVKSKPGTGEPQQVPPEPGKKQQQKAAQNHMQEQSQASVRQKGTADSVSWAGFQTKAEVEHVELPDGKKRRKVLALPSHRGPKIRLRDKGKMKPLPPKKPKPQTNHQKQEKQKLSSKQVPRKKAKGNKTEVRFNQLVEQYKQKLLGLSKGVPLAKRSKWFDS", "length": 753, "header": "tr|E1BLD4-1|E1BLD4_BOVIN Isoform 1 of RNA-binding protein 28 OS=Bos taurus OX=9913 GN=RBM28 PE=4 SV=3 CANONICAL=E1BLD4-1" }, "isoforms": [ { "isoform_ac": "E1BLD4-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD4/entry#E1BLD4-1", "sequence": { "sequence": "MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMVEDVQRALKEITTFEGCKINVTIAKKKLRNKSKEKGKTENSESPEKELKPKKAKVADKKARLIIRNLSFKCSEDDLKTVFSQFGTILEVNIPRKPDGKMRGFAFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKSTQSASIPGEEKRPEPEHQELDQENGREEEDMEEGENESDYDDDEEEEEDKESKLPKSVQIHKRAVKRPAPAESSDEEHSDDDSDLEERDSIDGGEDLAQSDTSSEEQEEEDIEVSKKKRKKRKLPSDVNEGKTVFIRNLSFDSEEEDLGELLQQFGDLKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLEAASPEAEGGGLKLDGRQLKVDLAVTRDEAAKLRTKKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLNSTRGEKAVRIKECRVMRDLKGAYGKIKGQSLGYAFAEFQEHEHALAALRHINNNPEIFGPQKRPIVEFSLEDRRKLKVKELRIQRSQQKVKSKPGTGEPQQVPPEPGKKQQQKAAQNHMQEQSQASVRQKGTADSVSWAGFQTKAEVEHVELPDGKKRRKVLALPSHRGPKIRLRDKGKMKPLPPKKPKPQTNHQKQEKQKLSSKQVPRKKAKGNKTEVRFNQLVEQYKQKLLGLSKGVPLAKRSKWFDS", "length": 753, "header": "tr|E1BLD4-1|E1BLD4_BOVIN Isoform 1 of RNA-binding protein 28 OS=Bos taurus OX=9913 GN=RBM28 PE=4 SV=3 CANONICAL=E1BLD4-1" }, "locus": { "chromosome": "4", "start_pos": 92531530, "end_pos": 92501085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022610.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022610.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022610.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022610.6" } ] } }, { "isoform_ac": "G3MZL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD4/entry#G3MZL2-1", "sequence": { "sequence": "MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKENSESPEKELKPKKAKVADKKARLIIRNLSFKCSEDDLKTVFSQFGTILEVNIPRKPDGKMRGFAFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKSTQSASIPGEEKRPEPEHQELDQENGREEEDMEEGENESDYDDDEEEEEDKESKLPKSVQIHKRAVKRPAPAESSDEEHSDDDSDLEERDSIDGGEDLAQSDTSSEEQEEEEVSKKKRKKRKLPSDVNEGKTVFIRNLSFDSEEEDLGELLQQFGDLKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLEAASPEAEGGGLKLDGRQLKVDLAVTRDEAAKLRTKKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLNSTRGEKAVRIKECRVMRDLKGAYGKIKGQSLGYAFAEFQEHEHALAALRHINNNPEIFGPQKRPIVEFSLEDRRKLKVKELRIQRSQQKVKSKPGTGEPQQVPPEPGKKQQQKAAQNHMQEQSQASVRQKGTADSVSWAGFQTKAEVEHVELPDGKKRRKVLALPSHRGPKIRLRDKGKMKPLPPKKPKPQTNHQKQEKQKLSSKQVPRKKAKGNKTEVRFNQLVEQYKQKLLGLSKGVPLAKRSKWFDS", "length": 698, "header": "tr|G3MZL2-1|G3MZL2_BOVIN Computationally mapped isoform of RNA binding motif protein 28 OS=Bos taurus OX=9913 GN=RBM28 PE=4 SV=2 CANONICAL=E1BLD4-1" }, "locus": { "chromosome": "4", "start_pos": 92531530, "end_pos": 92501085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065989.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065989.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055012.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055012.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1BLD4", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 753, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLD4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BLD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLD4" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 80, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 335, "end_pos": 337 }, { "start_pos": 503, "end_pos": 505 }, { "start_pos": 718, "end_pos": 720 }, { "start_pos": 74, "end_pos": 76 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BLE0-1", "uniprot_ac": "E1BLE0", "uniprot_id": "E1BLE0_BOVIN", "mass": { "chemical_mass": 27570.0, "monoisotopic_mass": 27570.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100125946", "type": "recommended", "evidence": [ { "id": "E1BLE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ] } ], "protein_names": [ { "name": "Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)", "type": "synonym", "evidence": [ { "id": "E1BLE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLE0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100125946", "url": "https://www.uniprot.org/uniprotkb/E1BLE0", "locus": {} } ], "crossref": [ { "id": "E1BLE0", "url": "https://alphafold.ebi.ac.uk/entry/E1BLE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013055", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NRTTEIC", "url": "https://omabrowser.org/oma/group/NRTTEIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BLE0", "url": "https://www.orthodb.org/?gene=E1BLE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLLLLVALLSPTGEAGKIIGGHEAKPHSRPYMAFLLFKTSGKSHICGGFLVREDFVLTAAHCLGSSINVTLGAHNIMERERTQQVIPVRRPIPHPDYNDETLANDIMLLKLTRKADITDKVSPINLPRSLAEVKPGMMCSVAGWGRLGVNMPSTDKLQEVDLEVQSEEKCIARFKNYIPFTQICAGDPSKRKNSFSGDSGGPLVCNGVAQGIVSYGRNDGTTPDVYTRISSFLSWIHSTMRRYKRQGSV", "length": 251, "header": "tr|E1BLE0-1|E1BLE0_BOVIN Isoform 1 of Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) OS=Bos taurus OX=9913 GN=LOC100125946 PE=1 SV=4 CANONICAL=E1BLE0-1" }, "isoforms": [ { "isoform_ac": "E1BLE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLE0/entry#E1BLE0-1", "sequence": { "sequence": "MVLLLLLVALLSPTGEAGKIIGGHEAKPHSRPYMAFLLFKTSGKSHICGGFLVREDFVLTAAHCLGSSINVTLGAHNIMERERTQQVIPVRRPIPHPDYNDETLANDIMLLKLTRKADITDKVSPINLPRSLAEVKPGMMCSVAGWGRLGVNMPSTDKLQEVDLEVQSEEKCIARFKNYIPFTQICAGDPSKRKNSFSGDSGGPLVCNGVAQGIVSYGRNDGTTPDVYTRISSFLSWIHSTMRRYKRQGSV", "length": 251, "header": "tr|E1BLE0-1|E1BLE0_BOVIN Isoform 1 of Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) OS=Bos taurus OX=9913 GN=LOC100125946 PE=1 SV=4 CANONICAL=E1BLE0-1" }, "locus": { "chromosome": "21", "start_pos": 34743223, "end_pos": 34741265, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017359.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017359.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017359.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017359.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "pmid": "" }, { "name": "granzyme-mediated programmed cell death signaling pathway", "id": "GO:0140507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140507", "evidence": [ { "database": "UniProtKB", "id": "E1BLE0", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BLE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 251, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BLE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BLE0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BLE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLE0" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 243, "start_aa": "Ile", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] } ]